Miracle-dz/UniFAR-FTUs huggingface dataset:
Feature-driven visual analytics of soccer data

Soccer is one the most popular sports today and also very interesting from an scientific point of view. We present a system for analyzing high-frequency position-based soccer data at various levels of detail, allowing to interactively explore and analyze for movement features and game events. Our Visual Analytics method covers single-player, multi-player and event-based analytical views. Depending on the task the most promising features are semi-automatically selected, processed, and visualized. Our aim is to help soccer analysts in finding the most important and interesting events in a match. We present a flexible, modular, and expandable layer-based system allowing in-depth analysis. The integration of Visual Analytics techniques into the analysis process enables the analyst to find interesting events based on classification and allows, by a set of custom views, to communicate the found results. The feedback loop in the Visual Analytics pipeline helps to further improve the classification results. We evaluate our approach by investigating real-world soccer matches and collecting additional expert feedback. Several use cases and findings illustrate the capabilities of our approach.
Temperament profiles associated with internalizing and externalizing problems in preadolescence

This study investigates how temperament factors are linked to internalizing and externalizing problems in a Dutch population sample of preadolescents (N = 2230). Internalizing and externalizing problems were assessed by the Child Behavior Checklist and the Youth Self-Report and temperament was evaluated by the parent-version of the Revised Early Adolescent Temperament Questionnaire. Temperament profiles were examined in children with (a) neither internalizing nor externalizing problems, (b) only internalizing problems, (c) only externalizing problems, and (d) both internalizing and externalizing problems. The results suggest clearly diverging temperament profiles for these groups of children, with High-Intensity Pleasure and Shyness (representing the broad dimension of Surgency) steering the conditional probability of internalizing and externalizing problems (direction markers), Frustration mainly being related to maladaptation in general (severity marker), and Fear and Effortful Control being associated with both the severity and the direction of internalizing and externalizing problems, respectively. Girls and boys differed in the distribution across the problem groups, but the associations between temperament and psychopathology were comparable for both genders.This research is part of the Tracking Adolescents' Individual Lives Survey (TRAILS). Participating centers of TRAILS include various Departments of the University of Groningen, the Erasmus Medical Center of Rotterdam, the Vrije University of Amsterdam, the University of Nijmegen, and the Trimbos Institute, The Netherlands. TRAILS is financially supported by grants from the Netherlands Organization for Scientific Research (GB-MW 940-38-011, GB-MAG 480-01-006, ZonMw 100-001-001) and the Ministry of Justice (to F.C.V.) and by the participating centers.
Massive Quiescent Cores in Orion. I. Temperature Structure

We have mapped four massive cores in Orion using the NH3 (J,K) = (1, 1) and (J,K) = (2, 2) inversion transitions as part of our effort to study the pre-protostellar phase of massive star formation. These cores were selected to be quiescent; i.e., they contain no apparent IR sources and are not associated with any molecular outflows. These cores are 1 order of magnitude more massive than dark cloud cores and have about twice the line width. This paper focuses on their temperature structure. We find a statistically significant correlation between the gas kinetic temperature and the gas column density. The general trend is for the gas to be colder where the column density is higher, which we interpret to mean that the interiors of these cores are colder than the regions surrounding them. This is in contrast with dark cloud cores, which exhibit relatively flat temperature profiles. The temperature gradient within the massive quiescent Orion cores is consistent with an external radiation source heating the dust and dust-gas collisions providing relatively close coupling between dust and gas temperatures. Thus, we suggest that the initial stage of massive pre-protostellar cloud cores is relatively quiescent condensations that are cooler than their surroundings.
Widespread Occurrence of Secondary Lipid Biosynthesis Potential in Microbial Lineages

Bacterial production of long-chain omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), is constrained to a narrow subset of marine γ-proteobacteria. The genes responsible for de novo bacterial PUFA biosynthesis, designated pfaEABCD, encode large, multi-domain protein complexes akin to type I iterative fatty acid and polyketide synthases, herein referred to as “Pfa synthases”. In addition to the archetypal Pfa synthase gene products from marine bacteria, we have identified homologous type I FAS/PKS gene clusters in diverse microbial lineages spanning 45 genera representing 10 phyla, presumed to be involved in long-chain fatty acid biosynthesis. In total, 20 distinct types of gene clusters were identified. Collectively, we propose the designation of “secondary lipids” to describe these biosynthetic pathways and products, a proposition consistent with the “secondary metabolite” vernacular. Phylogenomic analysis reveals a high degree of functional conservation within distinct biosynthetic pathways. Incongruence between secondary lipid synthase functional clades and taxonomic group membership combined with the lack of orthologous gene clusters in closely related strains suggests horizontal gene transfer has contributed to the dissemination of specialized lipid biosynthetic activities across disparate microbial lineages.
A Distinct Repertoire of Autoantibodies in Hepatocellular Carcinoma Identified by Proteomic Analysis*

Chronic infections with hepatitis B (HBV) and hepatitis C (HCV) viruses are major risk factors for hepatocellular carcinoma (HCC). We have utilized a proteomic approach to determine whether a distinct repertoire of autoantibodies can be identified in HCC. Sera from 37 patients with HCC and 31 subjects chronically infected with HBV or HCV without HCC were investigated. Sera from 116 patients with other cancers, three patients with systemic lupus erythematosus, and 24 healthy subjects were utilized as controls. We report the identification of eight proteins, for each of which autoantibodies were detected in sera from more than 10% of patients with HCC but not in sera from healthy individuals (p < 0.05). Autoantibodies to four of these proteins were detected at a comparable frequency in sera from patients with chronic hepatitis. The other four proteins, which consisted of calreticulin isoforms, cytokeratin 8, nucleoside diphosphate kinase A, and F1-ATP synthase β-subunit, induced autoantibodies among patients with HCC, independently of their HBV/HCV status. Calreticulin, and a novel truncated form of calreticulin (Crt32) we have identified, most commonly elicited autoantibodies among patients with HCC (27%). We conclude that a distinct repertoire of autoantibodies is associated with HCC that may have utility in early diagnosis of HCC among high risk subjects with chronic hepatitis.
Design and control of mechanical structures for sit-to-rehabilitation training

Physical rehabilitation training using an intelligent control system is important for the people with lower limb dysfunction. In this paper, the sit-to-stand (STS) trajectory of health persons is researched based on STS biomechanics model. Several novel mechanical structures for intelligent lower limb STS rehabilitation training system are presented. According to the mechanical analysis of its finite element model, the size and structure was optimized using software (Hyperworks). Finally, a mechanical structure with several degrees of freedom is designed and optimized. Each joint angle of the lower limb in the STS process is assessed by experiment and used to instruct the control of the designed lower limb rehabilitation training robot. The results show that the mechanical structures and the STS biomechanical model are suitable for the lower limb rehabilitation training.
Evidence That Long-Term Potentiation Occurs within Individual Hippocampal Synapses during Learning

Stabilization of long-term potentiation (LTP) depends on multiple signaling cascades linked to actin polymerization. We used one of these, involving phosphorylation of the regulatory protein cofilin, as a marker to test whether LTP-related changes occur in hippocampal synapses during unsupervised learning. Well handled rats were allowed to explore a compartmentalized environment for 30 min after an injection of vehicle or the NMDA receptor antagonist (±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP). Another group of rats consisted of vehicle-injected, home-cage controls. Vehicle-treated rats that explored the environment had 30% more spines with dense phosphorylated (p) cofilin immunoreactivity in hippocampal field CA1 than did rats in the home-cage group. The increase in pCofilin-positive spines and behavioral evidence for memory of the explored environment were both eliminated by CPP. Coimmunostaining for pCofilin and the postsynaptic density protein 95 (PSD-95) showed that synapses on pCofilin-positive spines were substantially larger than those on neighboring (pCofilin-negative) spines. These results establish that uncommon cellular events associated with LTP, including changes in synapse size, occur in individual spines during learning, and provide a technique for mapping potential engrams.
BMD Loci Contribute to Ethnic and Developmental Differences in Skeletal Fragility across Populations: Assessment of Evolutionary Selection Pressures

Bone mineral density (BMD) is a highly heritable trait used both for the diagnosis of osteoporosis in adults and to assess bone health in children. Ethnic differences in BMD have been documented, with markedly higher levels in individuals of African descent, which partially explain disparity in osteoporosis risk across populations. To date, 63 independent genetic variants have been associated with BMD in adults of Northern-European ancestry. Here, we demonstrate that at least 61 of these variants are predictive of BMD early in life by studying their compound effect within two multiethnic pediatric cohorts. Furthermore, we show that within these cohorts and across populations worldwide the frequency of those alleles associated with increased BMD is systematically elevated in individuals of Sub-Saharan African ancestry. The amount of differentiation in the BMD genetic scores among Sub-Saharan and non-Sub-Saharan populations together with neutrality tests, suggest that these allelic differences are compatible with the hypothesis of selective pressures acting on the genetic determinants of BMD. These findings constitute an explorative contribution to the role of selection on ethnic BMD differences and likely a new example of polygenic adaptation acting on a human trait.
The Efficacy of Acceptance and Commitment Therapy on Metacognitions and Anxiety in Women Outpatients with Generalized Anxiety Disorder in Iran

The purpose of the present study was to examine the comparative effectiveness of acceptance and commitment therapy (ACT) in the treatment of metacognitions and anxiety among women with generalized anxiety disorder. In total, 40 self-referred female outpatients were examined within a randomized controlled trial. Patients were allocated to ACT and waitlist control groups. Metacognitions and anxiety symptoms were measured by the Metacognitions Questionnaire and the Beck Anxiety Inventory at baseline, posttreatment, and 2-month follow-up. Analyses showed that the therapeutic group had improved significantly whilst the control group had remained unchanged.
Temporal and spatial variation in the δ15N and δ13C of coral tissue and zooxanthellae in Montastraea faveolata collected from the Florida reef tract

Tissues were collected from Montastraea faveolata at five locations on the Florida Reef tract representing both nearshore and offshore environments. The tissue and zooxanthellae were removed from the skeletons, separated, and subsequently analyzed for δ15N and δ13C. The mean δ15N value in the coral tissue was +6.6 (±0.6‰) while the δ13C was –13.3 (±0.5‰) (n = 197). The δ15N and δ13C of the zooxanthellae were +4.7 (±1.1‰) and –12.2 (±1.0‰), respectively (n = 147). The differences in the δ15N and δ13C between the zooxanthellae and the tissue were statistically significant. No statistically significant differences were observed between nearshore and offshore stations in either δ15N orδ13C. The absence of a difference casts doubt on both whether the δ15N of the coral tissues is related to anthropogenic influences and/or whether the δ15N value itself can be used as an indicator of sewage contamination in corals. Between 1995 and 1997, there was an increase of 1‰ in the δ13C and a decrease of approximately 0.8‰in the δ15N. The increase in the δ13C of the organic material was mimicked in the δ13C of the skeletal material from corals from two reefs in the area. There appears to be clear seasonal variations in the δ13C of the coral tissue at certain locations with δ13C of the coral tissues and the zooxanthellae becoming more positive between July and August. The difference between the δ13C of the zooxanthellae and the coral tissue varies seasonally with the maximum difference occurring in July of each year. In contrast, the maximum δ13C in the skeleton appears to occur later in the year, between September and November.
Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner

beta-Amyloid precursor protein (beta APP) is an integral membrane polypeptide expressed in many neural and non-neural cells. beta APP occurs in part at the cell surface and undergoes proteolytic processing to release the large soluble ectodomain (APPs) and the amyloid beta- peptide (A beta), both of which have apparent trophic activity in vitro. Despite intense interest in beta APP expression and metabolism, there is limited knowledge about the function mediated by beta APP inserted at the cell-surface. We established a coculture system in which beta APP-transfected CHO cells serve as a substrate for the growth of primary rat hippocampal neurons. Compared to nontransfected CHO cells, the increased surface beta APP of the transfectants stimulated short-term neuronal adhesion and longer-term neurite outgrowth, whereas the increased amount of secreted APPs and A beta in conditioned medium produced no such effects when neurons were grown either on untransfected CHO cells or on a polylysine substrate. Moreover, a peptide which has been shown to block the trophic effects of secreted APPs (Ninomiya et al., 1993) failed to interrupt the neurite promoting activity mediated by the surface-expressed beta APP. Surface-expressed beta APP751 or beta APP770 isoforms mediated more neurite outgrowth than did the beta APP695 isoform. Antibody blocking and regional deletion experiments indicated that the mid-region of the beta APP ectodomain (residues 361–648) is involved in promoting neurite outgrowth. We conclude that surface-expressed cellular beta APP has a neurite-promoting function which is distinct from the trophic function of the secreted beta APP derivatives and may have special significance during brain development.
Engrailed-1 and netrin-1 regulate axon pathfinding by association interneurons that project to motor neurons.

During early development, multiple classes of interneurons are generated in the spinal cord including association interneurons that synapse with motor neurons and regulate their activity. Very little is known about the molecular mechanisms that generate these interneuron cell types, nor is it known how axons from association interneurons are guided toward somatic motor neurons. By targeting the axonal reporter gene &tgr;-lacZ to the En1 locus, we show the cell-type-specific transcription factor Engrailed-1 (EN1) defines a population of association neurons that project locally to somatic motor neurons. These EN1 interneurons are born early and their axons pioneer an ipsilateral longitudinal projection in the ventral spinal cord. The EN1 interneurons extend axons in a stereotypic manner, first ventrally, then rostrally for one to two segments where their axons terminate close to motor neurons. We show that the growth of EN1 axons along a ventrolateral pathway toward motor neurons is dependent on netrin-1 signaling. In addition, we demonstrate that En1 regulates pathfinding and fasciculation during the second phase of EN1 axon growth in the ventrolateral funiculus (VLF); however, En1 is not required for the early specification of ventral interneuron cell types in the embryonic spinal cord.
Bounded LSH for Similarity Search in Peer-to-Peer File Systems

Similarity search has been widely studied in peer-to-peer environments. In this paper, we propose the Bounded Locality Sensitive Hashing (Bounded LSH) method for similarity search in P2P file systems. Compared to the basic Locality Sensitive Hashing (LSH), Bounded LSH makes improvement on the space saving and quick query response in the similarity search, especially for high-dimensional data objects that exhibit non-uniform distribution property. We present simple and space-efficient Bounded-LSH to map non-uniform data space into load-balanced hash buckets that contain approximate number of objects. Load-balanced hash buckets in Bounded-LSH, in turn, require less number of hash tables while maintaining a high probability of returning the closest objects to requests. Our experiments based on synthetic and real-world datasets showed the feasibility, query and space efficiency of our proposed method.
Adaptive Functioning in Williams Syndrome: A Systematic Review

Abstract Literature on the level of adaptive functioning and relative strengths and weaknesses in functioning of individuals with Williams syndrome (WS) was reviewed. The electronic databases PsycINFO, PubMed, Expanded Academic, Web of Science, Scopus and ProQuest were searched electronically for relevant articles and dissertations using the search terms ‘Williams syndrome’ or ‘Williams-Beuren syndrome’ combined with ‘adaptive function*’, ‘adaptive behavio*’, ‘independ*’ and ‘autonomy’. Selection criteria included English language articles, theses and book chapters, participants with a diagnosis of Williams syndrome and inclusion of a standardised assessment of adaptive functioning. Twenty-two published articles and two PhD. dissertations (one subsequently published as a poster presentation) met the selection criteria for inclusion in the review. Fifteen investigated adaptive functioning in children and adolescents aged up to 19 years of age, five investigated adaptive functioning in adults and four included participants across a wider age range and included both children and adults. Along with identifying methodological issues, the review addressed the following areas: overall level of adaptive functioning in WS, domain strengths and weaknesses, evidence of heterogeneity, relationship to intellectual ability, changes with chronological age, relationship with maladaptive behaviour, gender differences and the potential influence of environmental factors which may be related to adaptive functioning in WS.
How Mindsets Matter: Second Grade, English Language Learners’ Reportings Of Their Experiences With A Growth Mindset Curriculum In Colombia

This qualitative, classroom action research was conducted in a private bilingual school in Colombia with seventeen participants. The research questions were: 1) How do second-grade Colombian English language learners report changes to their Growth Mindset qualities following a six-week Growth Mindset intervention? and 2) How do second-grade Colombian English language learners perceive their language learning ability following a self-evaluation of Growth Mindset qualities? The research fills a gap in existing literature on three similar topics: Growth Mindset and academic achievement for adolescents and adults, conditional self-worth for children six and younger, and attribution theory and language learning for adolescents. One of the main objectives was to introduce language learning ability as a Growth quality to participants; that is, as malleable attribute that can be controlled and increased through effort, persistence, quality of strategy, and engagement in challenge. The research methods required participants to take a before-intervention questionnaire, participate in an age-appropriate, six-week Growth Mindset modeled after Blackwell’s et al. (2007) seminal study, and then take the same questionnaire after the intervention. Three participants were chosen to articulate their mindsets in a one-on-one interview. The data and results indicated diverse results between participants for all three subtopics studied despite nearly no change in students’ average mindsets. The discussion raised many questions as to why students’ results were so diverse and gives suggestions for how to support students in the area of conditional self-worth. HOW MINDSETS MATTER 3 Chapter 1: Introduction “When we deny the story, it defines us. When we own the story, we can write a brave new ending”
High interpopulation homogeneity in Central Argentina as assessed by Ancestry Informative Markers (AIMs)

The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA) in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs). Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But a most unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.
Exploring Aging Stereotypes and Age-Specific Physical Activity Factors Among Active Older Adults

vii LIST OF ABBREVIATIONS USED . viii ACKNOWLEDGEMENTS . ix CHAPTER 1: INTRODUCTION . 1 Purpose of Study . 3 Significance of the Study . 3 Study Design . 4 Importance and Relevance to Health Promotion . 5 Summary . 6 CHAPTER 2: LITERATURE REVIEW . 8 Implications of the Growing Aging Population . 8 Benefits of PA in Later Life . 9 Health Promotion for PA in Later Life . 10 The Need for a Psychosocial Approach in Health and PA Promotion in Later Life . 12 Age Stereotypes . 14 Health Implications of Positive and Negative Age Stereotypes . 15 Implications of Age Stereotypes on PA behaviour . 17 The Social-Ecological Model . 21 Research Gaps and Significance of Study . 24