Miracle-dz/UniFAR-FTUs huggingface dataset:
Online Built-In Self-Test of High Switching Frequency DC–DC Converters Using Model Reference Based System Identification Techniques

A built-in self-test (BIST) technique that enables tracking of loop parameters of integrated DC–DC converters without affecting the normal mode of operation is presented. A digital pseudo-noise based stimulus and a mixed signal cross-correlation based analysis technique is used to derive on-chip impulse response, with minimum computational requirements in comparison to a digital correlator approach. Using measured impulse response, open-loop phase margin and closed-loop unity-gain frequency are estimated within 5.2% and 4.1% error, respectively, for the load current range of 30 mA to 200 mA. Converter parameters, such as natural frequency, <inline-formula> <tex-math notation="LaTeX">$Q$ </tex-math></inline-formula>-factor, and center frequency are estimated within 3.6%, 4.7%, and 3.8% error, respectively, over load inductance of 4.7 <inline-formula> <tex-math notation="LaTeX">$\mu \text{H}$ </tex-math></inline-formula> to 10.3 <inline-formula> <tex-math notation="LaTeX">$\mu \text{H}$ </tex-math></inline-formula>, and filter capacitance of 200 nF to 400 nF. A 5 MHz switching frequency, 5 V to 8.125 V input voltage range, voltage-mode controlled DC-DC buck converter is designed for the proposed model reference based parametric and non-parametric BIST analysis. The converter output voltage range is 3.3 V to 5 V and supported maximum load current is 450 mA with a peak efficiency of 87.93%. The proposed converter is fabricated on a 0.6 <inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> 6 layer-metal SOI technology with a die area of 9 mm<sup>2</sup>. The system identification circuitry occupies 3.8% of the converter area with 530 <inline-formula> <tex-math notation="LaTeX">$\mu \text{A}$ </tex-math></inline-formula> quiescent current during operation.
Investigating the roles of interpersonal and interorganizational trust in IT outsourcing success

Purpose – Trust, as one of the core components of a relationship, has attracted research attention from many disciplines. From the perspective of IT outsourcing, this paper aims to divide trust into two levels, interpersonal trust and interorganizational trust, and explore the effects of these two levels of trust on knowledge sharing and IT outsourcing success.Design/methodology/approach – Based on social exchange theory and the theory of organization boundary systems, a theoretical model was developed and tested empirically with the responses to a cross‐sectional survey. Data were collected from key informants of 143 firms that had outsourced at least part of their IT functions.Findings – The data analysis results showed that interpersonal trust plays a more dominant role than does interorganizational trust in making IT outsourcing successful and the extent of knowledge sharing has a significant mediating effect between interpersonal trust and IT outsourcing success.Originality/value – From the manageria.
Phylogeography and mitochondrial diversity of extirpated brown bear (Ursus arctos) populations in the contiguous United States and Mexico

The fossil record indicates that the brown bear (Ursus arctos) colonized North America from Asia over 50 000 years ago. The species historically occupied the western United States and northern Mexico but has been extirpated from over 99% of this range in the last two centuries. To evaluate colonization hypotheses, subspecific classifications, and historical patterns and levels of genetic diversity in this region, we sequenced 229 nucleotides of the mitochondrial DNA control region in 108 museum specimens. The work was set in a global context by synthesizing all previous brown bear control region sequences from around the world. In mid‐latitude North America a single moderately diverse clade is observed, represented by 23 haplotypes with up to 3.5% divergence. Only eight of 23 haplotypes (35%) are observed in the extensively sampled extant populations suggesting a substantial loss of genetic variability. The restriction of all haplotypes from mid‐latitude North America to a single clade suggests that this region was founded by bears with a similar maternal ancestry. However, the levels and distributions of diversity also suggest that the colonizing population was not a small founder event, and that expansion occurred long enough ago for local mutations to accrue. Our data are consistent with recent genetic evidence that brown bears were south of the ice prior to the last glacial maximum. There is no support for previous subspecies designations, although bears of the southwestern United States may have had a distinctive, but recent, pattern of ancestry.
Correlations between Self-Defeating Personality and Self-Esteem

41 men and 56 women completed Schill's self-defeating personality scale and Coopersmith's self-esteem scale. The total scores from these instruments were significantly negatively correlated (ranges, –.50 to –.77). The inverse relationship between self-defeating personality and self-esteem appears to be higher for men than for women. However, no significant differences were found between the men's and women's scores on self-esteem or self-defeating personality scales. The results indicate the two scales measure similar but inverse orientations of individuals' internalized negative affect.
Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

ABSTRACT Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed to screen and evaluate novel tuberculosis drugs and drug regimens. Pulmonary disease in humans is characterized by a number of heterogeneous lesion types that reflect differences in cellular composition and organization, extent of encapsulation, and degree of caseous necrosis. C3HeB/FeJ mice have been increasingly used to model tuberculosis infection because they produce hypoxic, well-defined granulomas exhibiting caseous necrosis following aerosol infection with Mycobacterium tuberculosis. A comprehensive histopathological analysis revealed that C3HeB/FeJ mice develop three morphologically distinct lesion types in the lung that differ with respect to cellular composition, degree of immunopathology and control of bacterial replication. Mice displaying predominantly the fulminant necrotizing alveolitis lesion type had significantly higher pulmonary bacterial loads and displayed rapid and severe immunopathology characterized by increased mortality, highlighting the pathological role of an uncontrolled granulocytic response in the lung. Using a highly sensitive novel fluorescent acid-fast stain, we were able to visualize the spatial distribution and location of bacteria within each lesion type. Animal models that better reflect the heterogeneity of lesion types found in humans will permit more realistic modeling of drug penetration into solid caseous necrotic lesions and drug efficacy testing against metabolically distinct bacterial subpopulations. A more thorough understanding of the pathological progression of disease in C3HeB/FeJ mice could facilitate modulation of the immune response to produce the desired pathology, increasing the utility of this animal model. Summary: C3HeB/FeJ mice develop three morphologically distinct lesion types, which differ with respect to bacterial load, cellular composition and degree of immunopathology following low-dose aerosol infection with Mycobacterium tuberculosis.
A yoke of oxen and a thousand chickens for heavy lifting graph processing

Large, real-world graphs are famously difficult to process efficiently. Not only they have a large memory footprint but most graph processing algorithms entail memory access patterns with poor locality, data-dependent parallelism, and a low compute-to-memory access ratio. Additionally, most real-world graphs have a low diameter and a highly heterogeneous node degree distribution. Partitioning these graphs and simultaneously achieve access locality and load-balancing is difficult if not impossible. This paper demonstrates the feasibility of graph processing on heterogeneous (i.e., including both CPUs and GPUs) platforms as a cost-effective approach towards addressing the graph processing challenges above. To this end, this work (i) presents and evaluates a performance model that estimates the achievable performance on heterogeneous platforms; (ii) introduces TOTEM - a processing engine based on the Bulk Synchronous Parallel (BSP) model that offers a convenient environment to simplify the implementation of graph algorithms on heterogeneous platforms; and, (iii) demonstrates TOTEM'S efficiency by implementing and evaluating two graph algorithms (PageRank and breadth-first search). TOTEM achieves speedups close to the model's prediction, and applies a number of optimizations that enable linear speedups with respect to the share of the graph offloaded for processing to accelerators.
Guess Who's Texting You? Evaluating the Security of Smartphone Messaging Applications

In recent months a new generation of mobile messaging and VoIP applications for smartphones was introduced. These services offer free calls and text messages to other subscribers, providing an Internet-based alternative to the traditional communication methods managed by cellular network carriers such as SMS, MMS and voice calls. While user numbers are estimated in the millions, very little attention has so far been paid to the security measures (or lack thereof) implemented by these providers. In this paper we analyze nine popular mobile messaging and VoIP applications and evaluate their security models with a focus on authentication mechanisms. We find that a majority of the examined applications use the user’s phone number as a unique token to identify accounts, which further encumbers the implementation of security barriers. Finally, experimental results show that major security flaws exist in most of the tested applications, allowing attackers to hijack accounts, spoof sender-IDs or enumerate subscribers.
Numerical and Experimental Analysis of Sensitivity-Enhanced RI Sensor Based on Ex-TFG in Thin Cladding Fiber

We report a highly sensitive refractive index (RI) sensor in the aqueous solution, which is based on an 81°-tilted fiber grating structure inscribed into a thin cladding fiber with 40 μm cladding radius. The numerical analysis has indicated that the RI sensitivity of cladding resonance mode of the grating can be significantly enhanced with reducing cladding size. This has been proved by the experimental results as the RI sensitivities of TM and TE resonance peaks in the index region of 1.345 have been increased to 1180 nm/RIU and 1150 nm/RIU, respectively, from only 200 and 170 nm/RIU for the same grating structure inscribed in standard telecom fiber with 62.5-μm cladding radius. Although the temperature sensitivity has also increased, the change in temperature sensitivity is still insignificant in comparison with RI sensitivity enhancement.
Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes

The proteasome is a 700-kD multisubunit enzyme complex with several proteolytically active sites. The enzyme complex is involved in both ubiquitin-dependent and -independent protein degradation and may contribute to the processing of antigens presented by major histocompatibility complex (MHC) class I molecules. Here we demonstrate that treatment of mouse fibroblast cells with 20 U interferon gamma (IFN-gamma) for 3 d induces a change in the proteasome subunit composition and that the beta-type subunit LMP2, which is encoded in the MHC class II region, is incorporated into the enzyme complex. This is paralleled by reduction of the homologous delta-subunit. IFN-gamma stimulation results in a downregulation of the chymotrypsin-like Suc- LLVY-MCA peptide hydrolyzing activity of 20S proteasomes whereas the trypsin-like activity remains unaffected. When tested as a substrate a synthetic 25-mer polypeptide whose sequence covers the antigenic nonapeptide YPHFMPTNL of the MCMV pp89, 20S proteasomes of IFN-gamma- induced cells exhibit altered chymotrypsin-like cleavage site preferences. In the absence of IFN-gamma induction, the naturally processed nonamer peptide that is presented by MHC class I molecules appears as a minor cleavage product. IFN-gamma activation does not result in an increase of the final peptide but results in a different set of peptides. We hypothesize that these peptides represent precursor peptides that can be trimmed to final peptide size.
Learnability and Stability in the General Learning Setting

We establish that stability is necessary and sufficient for learning, even in the General Learning Setting where uniform convergence conditions are not necessary for learning, and where learning might only be possible with a non-ERM learning rule. This goes beyond previous work on the relationship between stability and learnability, which focused on supervised classification and regression, where learnability is equivalent to uniform convergence and it is enough to consider the ERM.
A tunable dispersion compensating MEMS all-pass filter

A tunable dispersion compensating filter based on a multistage optical all-pass filter with a microelectromechanical (MEM) actuated variable reflector and a thermally tuned cavity is described. A two-stage device was demonstrated with a tuning range of /spl plusmn/100 ps/nm, 50-GHz passband and a group delay ripple less than /spl plusmn/3 ps. The device has negligible polarization dependence and is suitable for single or multiple channel compensation. An off-axis, two-fiber package with an excess loss <2 dB/stage avoids the need for a circulator. By cascading four stages, a passband to channel spacing ratio of 0.8 is obtained that allows both 40 Gb/s nonreturn-to-zero (NRZ) and return-to-zero (RZ) signals to be compensated.
Bit-Level Multiplierless FIR Filter Optimization Incorporating Sparse Filter Technique

Multiplierless FIR filter optimization has been extensively studied in the past decades to minimize the number of adders. A more accurate measurement of the implementation complexity is the number of full adders counted at bit-level. However, the high computational complexity of the optimization at bit-level hinders the technique from practical applications. In this paper, the sparse filter technique is exploited and makes the search space at bit-level significantly reduced. Thus, the bit-level optimization of multiplierless FIR filters for the first time becomes possible. When the sparse filter technique is employed for the multiplierless filter design, the sparsity of the filter is properly controlled so that the feasibility of the bit-level optimization in discrete space is maintained. Thereafter, in the reduced search space, a tree search algorithm is formulated at bit-level, and techniques to estimate the bit level hardware cost and to accelerate the search are presented. Design examples show that the proposed bit-level optimization method generates designs with lower hardware cost and power consumption than that of the best word-level optimization methods, while the design time is still at an acceptable level. The average power savings to 3 recent published techniques are 13.6%, 8.0% and 26.1%, respectively.
Promoter mapping and transcriptional regulation of the iron assimilation system of plasmid ColV-K30 in Escherichia coli K-12

The promoter of the high-affinity iron assimilation system coded in an approximately 8-kilobase-pair segment of the large Escherichia coli plasmid ColV-K30 was localized to a 0.7-kilobase HindIII-SalI fragment by in vitro runoff transcription. By an S1 nuclease protection assay, with in vitro-transcribed RNA and total in vivo-synthesized RNA, the major start site for transcription was mapped within this fragment and found to be identical in vitro and in vivo. A minor initiation site was located about 50 base pairs upstream from the major site. DNA sequencing of the HindIII-SalI fragment revealed the presence of two promoter-like structures within an extremely AT-rich region with transcriptional initiation sites at 30 and about 80 base pairs upstream from the initiation codon for the first structural gene. Numerous potential secondary structures were found in the DNA sequence around the major promoter. The major transcriptional start site was determined precisely by sequencing the 5' end of in vitro-transcribed RNA. The effect of iron on both the level of specific RNA, as determined by a quantitative S1 nuclease mapping assay, and on beta-galactosidase activity in a iucA'-'lacZ protein fusion, showed that the aerobactin operon is regulated at the transcriptional level. The iron-regulatory sequences are contained within a 152-base-pair Sau3A fragment of the promoter region.
Melanocytes from Patients Affected by Ullrich Congenital Muscular Dystrophy and Bethlem Myopathy have Dysfunctional Mitochondria That Can be Rescued with Cyclophilin Inhibitors

Ullrich congenital muscular dystrophy and Bethlem myopathy are caused by mutations in collagen VI (ColVI) genes, which encode an extracellular matrix protein; yet, mitochondria play a major role in disease pathogenesis through a short circuit caused by inappropriate opening of the permeability transition pore, a high-conductance channel, which causes a shortage in ATP production. We find that melanocytes do not produce ColVI yet they bind it at the cell surface, suggesting that this protein may play a trophic role and that its absence may cause lesions similar to those seen in skeletal muscle. We show that mitochondria in melanocytes of Ullrich congenital muscular dystrophy and Bethlem myopathy patients display increased size, reduced matrix density, and disrupted cristae, findings that suggest a functional impairment. In keeping with this hypothesis, mitochondria (i) underwent anomalous depolarization after inhibition of the F-ATP synthase with oligomycin, and (ii) displayed decreased respiratory reserve capacity. The non-immunosuppressive cyclophilin inhibitor NIM811 prevented mitochondrial depolarization in response to oligomycin in melanocytes from both Ullrich congenital muscular dystrophy and Bethlem myopathy patients, and partially restored the respiratory reserve of melanocytes from one Bethlem myopathy patient. These results match our recent findings on melanocytes from patients affected by Duchenne muscular dystrophy (Pellegrini et al., 2013), and suggest that skin biopsies may represent a minimally invasive tool to investigate mitochondrial dysfunction and to evaluate drug efficacy in ColVI-related myopathies and possibly in other muscle wasting conditions like aging sarcopenia.
Value and Momentum Everywhere

Value and momentum ubiquitously generate abnormal returns for individual stocks within several countries, across country equity indices, government bonds, currencies, and commodities. We study jointly the global returns to value and momentum and explore their common factor structure. We find that value (momentum) in one asset class is positively correlated with value (momentum) in other asset classes, and value and momentum are negatively correlated within and across asset classes. Liquidity risk is positively related to value and negatively to momentum, and its importance increases over time, particularly following the liquidity crisis of 1998. These patterns emerge from the power of examining value and momentum everywhere simultaneously and are not easily detectable when examining each asset class in isolation.
Did Facebook absorb freewill

5 Introduction 6 Rationale 32 Literature Review 36 Method 74 Results 92 Discussion 99 Limitations 102 Conclusion 103 References 105 Appendix A 134 Appendix B 145 Appendix C 151 Appendix D 152 Appendix E 153 Appendix F 154 Appendix G 155 Did Facebook Absorb Free Will? 5 Abstract Previous studies on social networking sites have failed to address comprehensively the level of efficacy and role of peer influences in the rise in membership levels of this new communication innovation. This study assessed the level of social influences at play in college students‘ decision to participate on Facebook. Online and postal surveys were sent to undergraduate students of a Northeastern institution of higher education to obtain self-reported of levels of perceived peer pressure influencing their participation on Facebook. The data collected were used to test a new theory of social conformity. No relationship was found between time spent on Facebook in a typical week and peer
Glucocerebroside Ameliorates the Metabolic Syndrome in OB/OB Mice

Glucocerebroside (GC) is a naturally occurring glycolipid that may alter natural killer T (NKT) cell function. To determine the effect of GC on the metabolic derangements and immune profile in leptin-deficient mice, Ob/Ob mice were treated by daily injections of GC for 8 weeks and followed for various metabolic and immunological parameters. Marked amelioration of the metabolic alterations characteristic of leptin-deficient mice was observed in GC-treated animals compared with controls. A significant decrease in liver size and hepatic fat content were observed in GC-treated mice. Near-normalization of glucose tolerance and decreased serum triglyceride levels were observed. Fluorescence-activated cell sorting analysis of peripheral and intrahepatic lymphocytes revealed a 1.6-fold increase of the peripheral/intrahepatic NKT lymphocyte ratio. A 33% decrease of serum interferon-γ level and a 2.6-fold increase of serum interleukin 10 level were noted in GC-treated mice. Immune modulation by GC may have a role in the treatment of nonalcoholic steatohepatitis and other immune-mediated disorders.
Jamestown Canyon virus: seroprevalence in Connecticut.

Vol. 7, No. 5, September-October 2001 911 Emerging Infectious Diseases (blaPER-1 and blaVIM-2 ) had been detected separately among clinical isolates, underscores the possibility of the emergence of new threatening combinations of resistance determinants among nosocomial pathogens. In fact, the recruitment of similar resistance determinants within a single P. aeruginosa strain can determine a resistance phenotype to virtually all the available antipseudomonal beta-lactams, an occurrence that can be particularly dramatic when, as in the present case, resistance to beta-lactams is associated with resistance against aminoglycosides and fluoroquinolones. In this case, only piperacillin (which appears to be a relatively poor substrate for both enzymes [3,5]) retained moderate activity in vitro and, administered at high dosage in combination with tazobactam, was apparently effective in vivo. Should a similar resistance phenotype disseminate, it might have strategic implications for the development of new betalactamase inhibitors and for selection of beta-lactam compounds to associate wth inhibitors.