Miracle-dz/UniFAR-FTUs huggingface dataset:
Lingual pustular psoriasis and acrodermatitis continua of hallopeau successfully treated with adalimumab: A rare and interesting case report

Case Report: We had 2 patients presenting at the Skin City OPD, first was 11 years old male with complaints of three white patches with leukotrichia on his scalp for 5 years which were non-progressive. One of the patch was on right side lock and other two patches were over frontal forelock extending to mid scalp of size. The second patient was a 28 year old male with similar complaints since 20 years over the occipital area extending to the nape of the neck. We advised both them follicular unit hair grafting and subsequent excimer laser treatment.
Hearing Voices Network groups: experiences of eight voice hearers and the connection to group processes and recovery

Abstract Voice hearing has a diverse history but is often understood as symptomatic of a psychotic disorder. Alternatives to “treatment” include peer-support “Hearing Voices Network groups” (HVNGs) which have grown in popularity and exist alongside professional-led hearing voices groups. Few studies have investigated processes underlying change in HVNGs. Established research into therapeutic factors and personal recovery may provide frameworks elucidating change processes. This study aimed to investigate how HVNG attendees experienced change within the group and how this change influenced their lives. A qualitative design was employed using interpretative phenomenological analysis to elucidate group processes through immersion in the perspectives of group attendees. Semi-structured interviews were conducted with eight voice hearers from two HVNGs. Interviews were recorded and transcribed verbatim. Four superordinate themes emerged: “healing: connecting with humanity”; “group as an emotional container”; “making sense of the voices and me”; and “freedom to be myself and grow”. Relationships, safety, exploration of voices and group ownership were key components of HVNG, but require further study. These components were consistent with therapeutic factors and known recovery processes, so these established frameworks could be used to further investigate change processes in HVNGs.
Evolutionary dynamics of a quantitative trait in a finite asexual population

In finite populations, mutation limitation and genetic drift can hinder evolutionary diversification. We consider the evolution of a quantitative trait in an asexual population whose size can vary and depends explicitly on the trait. Previous work showed that evolutionary branching is certain (“deterministic branching”) above a threshold population size, but uncertain (“stochastic branching”) below it. Using the stationary distribution of the population’s trait variance, we identify three qualitatively different sub-domains of “stochastic branching” and illustrate our results using a model of social evolution. We find that in very small populations, branching will almost never be observed; in intermediate populations, branching is intermittent, arising and disappearing over time; in larger populations, finally, branching is expected to occur and persist for substantial periods of time. Our study provides a clearer picture of the ecological conditions that facilitate the appearance and persistence of novel evolutionary lineages in the face of genetic drift.
Predictors of Treatment Resistance in Patients with Schizophrenia : a Population-based Cohort Study

See below for recent articles and other items of interest on Psychosis. If you wish to see the full text and there is a link below the abstract you should be able to access the article using your Athens password. If there is no link or you have any problems please email library.moorgreen@southernhealth.nhs. uk. Refugees experience higher rates of psychotic symptoms, in particular auditory hallucinations. This study aimed to explore the experience of refugees diagnosed with psychosis from a first-person perceptive. Seven refugees from a routine clinical service who had experienced trauma were interviewed. Interpretative phenomenological analysis was employed, generating six main themes: bleak agitated immobility, trauma-related perceptions, fear and mistrust of others, the sense of a broken self, the pain of losing everything, and the attraction of death. Six participants experienced voices, sounds, or visual phenomena thematically linked to past trauma. The sense of hopelessness was striking. Potential aims for therapy are a focus on helplessness, fear and coping, but also on the person's lack of a sense of purpose, trust and engagement in everyday activities. There is evidence of a positive association between insight and depression among patients with schizophrenia. Self-stigma was shown to play a mediating role in this association. We attempted to broaden this concept by investigating insight as a potential moderator of the association between de-pressive symptoms amongst people with schizo-phrenia and stigmatizing views towards people with mental disorders in their close social environment. In the initial sample of 120 pairs, data were gathered from 96 patients with a diagnosis of " paranoid schizophrenia " and 96 of their nearest relatives (80% response rate). In this cross-sectional study data were collected by clinical interview using the following questionnaires: " The Scale to Assess Un-awareness of Mental Disorder, " " Calgary Depression Scale for Schizophrenia, " and " Brief Psychiatric Rating Scale. " The stigmatizing views of pa-tients' nearest relatives towards people with mental disorders were assessed with the " Mental Health in Public Conscience " scale. Among patients with schizophrenia depressive symptom severity was positively associated with the intensity of nearest relatives' stigmatizing beliefs (" Nonbiological vision of mental illness, " τ = 0.24; P < .001). The association was moderated by the level of patients' awareness of presence of mental disorder while controlling for age, sex, duration of illness and psychopathological symptoms. The results support the hypothesis that the positive association between patients' depression and …
Direct reported speech in storytellings: Enacting and negotiating epistemic entitlements

Abstract This paper presents a study of participants’ use of direct reported speech (DRS) in storytelling during dinner table conversation in French. Focusing on reported dialogues, the analysis corroborates earlier conversation analytic findings showing that speakers regularly use linguistic, prosodic and paralinguistic resources to stage the characters whose speech is being reported; thereby speakers display their stance on behalf of those characters and their conduct. Additionally, the analysis documents that speakers use DRS within reported dialogues as a powerful means for depicting their own adequate conduct in the face of a purportedly “deviant” conduct of a third party. In the specific context of our data, in which an au-pair interacts with her host family, such direct reported dialogues are used both by the mother and the au pair as a means to enact shared expectations about the appropriateness of a caregiver’s conduct in the face of the “deviant” conduct of a child. In light of these findings, the representation of past dialogues by means of DRS appears as a practical resource by means of which participants enact identities such as mother and caregiver and thereby reflexively construct and negotiate the related epistemic entitlements.
Wide-IF-Band CMOS Mixer Design

A wide-IF-band transistor mixer has been designed using a 0.13-¿m RF-CMOS process where its RF frequency is 8.7-17.4 GHz, local oscillator (LO) fixed at 17.4 GHz, and IF up to 8.7 GHz. Proper layout arrangement for the Marchand balun has been discussed and then implemented; the output amplitude and phase imbalance are less than 0.5 dB and 1 ° measured in the RF bandwidth. Related theories for the core mixing circuit are explored extensively and verified through simulation; broad bandwidth of the resistive double-balanced mixer is then confirmed in the IF aspect. The designed mixer has more than 10-dB conversion gain, matched RF, IF, and LO ports, and good port isolation over the intended wide bandwidth. The input-referred P1 dB is -17.5 dBm at 9 GHz and -16 dBm at 13 GHz. The third-order input intercept point is -6 dBm at 9 GHz and -5 dBm at 13 GHz. The noise figure is 7 dB at 9 GHz and 12.6 dB at 13 GHz. The power consumption is 40 mW for this 1.3-mm2 mixer chip.
Glycine Receptors in CNS Neurons as a Target for Nonretrograde Action of Cannabinoids

At many central synapses, endocannabinoids released by postsynaptic cells act retrogradely on presynaptic G-protein-coupled cannabinoid receptors to inhibit neurotransmitter release. Here, we demonstrate that cannabinoids may directly affect the functioning of inhibitory glycine receptor (GlyR) channels. In isolated hippocampal pyramidal and Purkinje cerebellar neurons, endogenous cannabinoids anandamide and 2-arachidonylglycerol, applied at physiological concentrations, inhibited the amplitude and altered the kinetics of rise time, desensitization, and deactivation of the glycine-activated current (IGly) in a concentration-dependent manner. These effects of cannabinoids were observed in the presence of cannabinoid CB1/CB3, vanilloid receptor 1 antagonists, and the G-protein inhibitor GDPβS, suggesting a direct action of cannabinoids on GlyRs. The effect of cannabinoids on IGly desensitization was strongly voltage dependent. We also demonstrate that, in the presence of a GABAA receptor antagonist, GlyRs may contribute to the generation of seizure-like activity induced by short bursts (seven stimuli) of high-frequency stimulation of inputs to hippocampal CA1 region, because this activity was diminished by selective GlyR antagonists (strychnine and ginkgolides B and J). The GlyR-mediated rhythmic activity was also reduced by cannabinoids (anandamide) in the presence of a CB1 receptor antagonist. These results suggest that the direct inhibition of GlyRs by endocannabinoids can modulate the hippocampal network activity.
Modeling Rhetoric in Scientific Publications

Despite the advent of computer-centered ways of creating and accessing scientific knowledge, the format of the scientific research article has remained basically unchanged. We have developed a model of a more appropriate form for research publications to structure scientific articles, based on a rhetorical structure which is ubiquitous in (natural) science papers. The model has three components: defining rhetorical elements inside the documents, the identification of the argumentational relationships between these elements; and the connection of data elements and entities to external sources.
Specific impairment of face‐processing abilities in children with autism spectrum disorder using the Let's Face It! skills battery

Although it has been well established that individuals with autism exhibit difficulties in their face recognition abilities, it has been debated whether this deficit reflects a category‐specific impairment of faces or a general perceptual bias toward the local‐level information in a stimulus. In this study, the Let's Face It! Skills Battery [Tanaka & Schultz, 2008] of developmental face‐ and object‐processing measures was administered to a large sample of children diagnosed with autism spectrum disorder (ASD) and typically developing children. The main finding was that when matched for age and IQ, individuals with ASD were selectively impaired in their ability to recognize faces across changes in orientation, expression and featural information. In a face discrimination task, ASD participants showed a preserved ability to discriminate featural and configural information in the mouth region of a face, but were compromised in their ability to discriminate featural and configural information in the eyes. On object‐processing tasks, ASD participants demonstrated a normal ability to recognize automobiles across changes in orientation and a superior ability to discriminate featural and configural information in houses. These findings indicate that the face‐processing deficits in ASD are not due to a local‐processing bias, but reflect a category‐specific impairment of faces characterized by a failure to form view‐invariant face representations and discriminate information in the eye region of the face.
Latinos and Higher Education: A Literature Review

This article is an overview of the Latino population within the United States, and within higher education. Changes in demography have led to an increase in Latinos in higher education. First-generation Latinos face unique cultural, linguistic, and socioeconomic challenges on campus. As a result, there has been an increase in English-language learners (ELLs), as well as an increase in the number of Hispanic-serving institutions (HSIs) across the country.
Graphic Novel Comprehension Among Learners with Differential Cognitive Styles and Reading Abilities

ABSTRACT Learners with poor reading skills are less able to acquire knowledge through text. Graphic novels may enhance reading comprehension skills owing to fewer words, more pictures, and an engaging storyline. This study considered the reading skills of 188 Chinese–English bilingual undergraduates, comparing their reading comprehension performance after reading pure texts and graphic novels. Results showed that students exhibited greater reading comprehension performance after reading graphic novels regardless of their varying cognitive styles and prior English reading abilities. In addition, students who read the graphic novels expressed a greater interest in exploring the topic further, as indicated by the number of further references they selected. Taking all of the findings together, the present study demonstrates that presentation mode plays an important role in 2nd language reading comprehension development. Therefore, educators need a more systematic way of educating preschool through Grade 12 students for visual literacy training.
On Acoustic Emotion Recognition: Compensating for Covariate Shift

Pattern recognition tasks often face the situation that training data are not fully representative of test data. This problem is well-recognized in speech recognition, where methods like cepstral mean normalization (CMN), vocal tract length normalization (VTLN) and maximum likelihood linear regression (MLLR) are used to compensate for channel and speaker differences. Speech emotion recognition (SER) is an important emerging field in human-computer interaction and faces the same data shift problems, a fact which has been generally overlooked in this domain. In this paper, we show that compensating for channel and speaker differences can give significant improvements in SER by modelling these differences as a covariate shift. We employ three algorithms from the domain of transfer learning that apply importance weights (IWs) within a support vector machine classifier to reduce the effects of covariate shift. We test these methods on the FAU Aibo Emotion Corpus, which was used in the Interspeech 2009 Emotion Challenge. It consists of two separate parts recorded independently at different schools; hence the two parts exhibit covariate shift. Results show that the IW methods outperform combined CMN and VTLN and significantly improve on the baseline performance of the Challenge. The best of the three methods also improves significantly on the winning contribution to the Challenge.
The relation between gastric vitamin C concentrations, mucosal histology, and CagA seropositivity in the human stomach

Background—Vitamin C may be protective against gastric cancer though infection withHelicobacter pylori is associated with a reduction in intragastric concentrations of vitamin C. Aims—To examine the effects ofH pylori infection, gastric juice pH, the severity and extent of gastric inflammation, and CagA antibody status of the individual on gastric juice and mucosal vitamin C concentrations. Patients—One hundred and fifteen patients undergoing routine gastroscopy for investigation of dyspepsia. Methods—High performance liquid chromatography was used to determine vitamin C concentrations. CagA antibody was detected by western blot analysis. Results—Gastric juice ascorbic acid concentration was significantly lower in patients infected withH pylori compared with those uninfected (19.3 μmol/l (interquartile range (IQR) 10.7–44.5) versus 66.9 μmol/l (IQR 24.4–94.2), p=0.003). The reduction in gastric juice ascorbic acid concentration was inversely related to the severity of gastritis (p=0.01). CagA positive patients had significantly lower gastric juice ascorbic acid concentrations than CagA negative ones (14.8 μmol/l (IQR 7.9–52.2) versus 39 μmol/l (IQR 19.9–142.2), p=0.05). Decreased gastric juice dehydroascorbic acid concentrations were observed in patients with gastric atrophy and intestinal metaplasia. Mucosal ascorbic acid concentrations were also significantly lower in infected patients than uninfected patients (p=0.04). Conclusions—The reduction in gastric vitamin C concentrations is related to gastric juice pH, the severity and extent of gastritis, the presence of H pylori, and the CagA antibody status of the individual. These findings may have implications in H pyloriassociated carcinogenesis.
UML CLASS DIAGRAM OR ENTITY RELATIONSHIP DIAGRAM? AN OBJECT-RELATIONAL CONCEPTUAL IMPEDANCE MISMATCH

It is now nearly 30 years since Peter Chen’s watershed paper “The Entity-Relationship Model ‐ towards a Unified View of Data”. [1] The entity relationship model and variations and extensions to it have been taught in colleges and universities for many years. In his original paper Peter Chen looked at converting his new ER model to the then existing data structure diagrams for the Network model. In recent years there has been a tendency to use a Unified Modelling Language (UML) class diagram for conceptual modeling for relational databases, and several popular course text books use UML notation to some degree [2] [3]. However Object and Relational technology are based on different paradigms. In the paper we argue that the UML class diagram is more of a logical model (implementation specific). ER Diagrams on the other hand, are at a conceptual level of database design dealing with the main items and their relationships and not with implementation specific detail. UML focuses on OOAD (Object Oriented Analysis and Design) and is navigational and program dependent whereas the relational model is set based and exhibits data independence. The ER model provides a well-established set of mapping rules for mapping to a relational model. In this paper we look specifically at the areas which can cause problems for the novice database designer due to this conceptual mismatch of two different paradigms. Firstly, transferring the mapping of a weak entity from an Entity Relationship model to UML and secondly the representation of structural constraints between objects. We look at the mixture of notations which students mistakenly use when modeling. This is often the result of different notations being used on different courses throughout their degree. Several of the popular text books at the moment use either a variation of ER, UML, or both for teaching database modeling. At the moment if a student picks up a text book they could be faced with either; one of the many ER variations, UML, UML and a variation of ER both covered separately, or UML and ER merged together. We regard this problem as a conceptual impedance mismatch. This problem is documented in [21] who have produced a catalogue of impedance mismatch problems between object-relational and relational paradigms. We regard the problems of using UML class diagrams for relational database design as a conceptual impedance mismatch as the Entity Relationship model does not have the structures in the model to deal with Object Oriented concepts
Lattice Distortions in the FeCoNiCrMn High Entropy Alloy Studied by Theory and Experiment

Lattice distortions constitute one of the main features characterizing high entropy alloys. Local lattice distortions have, however, only rarely been investigated in these multi-component alloys. We, therefore, employ a combined theoretical electronic structure and experimental approach to study the atomistic distortions in the FeCoNiCrMn high entropy (Cantor) alloy by means of density-functional theory and extended X-ray absorption fine structure spectroscopy. Particular attention is paid to element-resolved distortions for each constituent. The individual mean distortions are small on average, <1%, but their fluctuations (i.e., standard deviations) are an order of magnitude larger, in particular for Cr and Mn. Good agreement between theory and experiment is found.
Bacterioplankton community in Chesapeake Bay: Predictable or random assemblages

We monitored bacterioplankton communities from Chesapeake Bay over 2 years (2002‐2004) by use of denaturing gradient gel electrophoresis (DGGE) of PCR‐amplified 16S rRNA gene. Chesapeake Bay bacterioplankton exhibited a repeatable annual pattern and strong seasonal shifts. In winter, the bacterial communities were dominated by Alphaproteobacteria and Actinobacteria, whereas in summer, the predominant bacteria were members of Alphaproteobacteria, Gammaproteobacteria, Cyanobacteria, Actinobacteria, Planctomycetes, and Bacteroidetes. Phylotypes of Alphaproteobacteria and Actinobacteria present in warm seasons were different from those in cold seasons. Relatively stable communities were present in summer‐fall across the sampling years, whereas winter communities were highly variable interannually. Temporal variations in bacterial communities were best explained by changes of chlorophyll a (Chl a) and water temperature, but dissolved oxygen, ammonia, nitrite and nitrate, and viral abundance also contributed significantly to the bacterial seasonal variations.
Relations Between Socioeconomic Status, Subjective Social Status, and Health in Shanghai, China

Objectives Although research has established a strong link between socioeconomic status (SES) and health in Western settings, comparable work in China lags behind. Similarly, studies showing a unique relationship for subjective social status (SSS) and health above and beyond SES have yet to be tested in China. The present study addresses these gaps. Methods Regression analyses investigated the relationship between SES, SSS, and mental and physical health net of several covariates for 2,282 caregivers in Shanghai, China. Indirect relationships for SES through SSS were also tested. Results Results indicate that SES is linked to mental and physical health outcomes, but in complicated ways. SSS, on the other hand, is consistently and robustly linked to health outcomes above and beyond income, education, occupational prestige, and Hukou status. Further significant indirect effects were found through SSS for income, education, and Hukou status. Conclusion In China's context of rapid economic growth, relationships to SES and health appear complicated. However, subjective perceptions of status are consistently linked to health outcomes.