Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of the rationale for, and consequences of, nonprofit and for-profit ownership conversions.

OBJECTIVES To examine percursors to private hospitals conversion, both from nonprofit status to for-profit status and from for-profit to nonprofit status, as well as the effect of hospital conversions on hospital profitability, efficiency, staffing, and the probability of closure. DATA SOURCES The Health Care Financing Administration's Medicare Cost Reports and the American Hospital Association's Annual Survey of Hospitals. STUDY DESIGN Bivariate and multivariate analyses comparing conversion hospitals to nonconversion hospitals over time were conducted. DATA EXTRACTION METHODS The study sample consisted of all private acute care hospital conversions that occurred from 1989 through 1992. PRINCIPAL FINDINGS Hospitals that converted had significantly lower profit margins prior to converting than did nonconversion hospitals. This was particularly true for nonprofit to for-profit conversions. After converting, both nonprofit and for-profit hospitals significantly improved their profitability. Nonprofit to for-profit hospital conversions were associated with a decrease in the ratio of staff to patients. No association was found between for-profit to nonprofit conversion and staff-to-patient ratios. The difference seems partially attributed to the fact that nonprofit hospitals that converted had higher staff ratios than the industry average. For-profit to nonprofit hospital conversions were associated with an increase in the ratio of registered nurses to patients and administrators to patients, despite the fact that nonprofit and for-profit hospitals did not differ in these ratios. CONCLUSIONS The improvement in financial performance following hospital conversions may be a benefit to the community that policymakers want to consider when regulating hospital conversions.
Profit Maximizing Distributed Service System Design with Congestion and Elastic Demand

In this paper we develop a service network design model that explicitly takes into account the elasticity of customer demand with respect to travel distance and congestion delays. The model incorporates a feedback loop between customer demand and congestion at the facilities. The problem is to determine the number of facilities, their locations, their service capacity, and the assignment of customers to facilities so as to maximize the overall profit of the system. Two versions of the problem are presented. In one, each facility is modeled as an M/M/1 queuing system where the service rate is a decision variable; in the other one, the facility is modeled as an M/M/k queuing model where the service rate is given, but the number k is a decision variable. An exact algorithm and heuristics are developed and tested via computational experiments. Although our model is of the “directed choice” type where the assignment of customers to facilities is controlled by the decision maker, computational results show that in the vast majority of cases the customers are assigned to the utility-maximizing facility, indicating that there is no conflict between the customers' and decision makers' goals. A case study of locating preventive medicine clinics in Toronto, Ontario, illustrates the model.
Static analysis for path correctness of XML queries

A part of a query that will never contribute data to the query answer should be regarded as an error. This principle has been recently accepted into mainstream XML query languages, but was still waiting for a complete treatment. We provide here a precise definition for this class of errors, and define a type system that is sound and complete, in its search for such errors, for a core language, under mild restrictions on the use of recursion in type definitions. In the process, we describe a dichotomy among existential and universal type systems, which is essential to understand some specific features of our type system.
Doppler estimation of left ventricular filling pressures in patients with hypertrophic cardiomyopathy.

BACKGROUND Conventional Doppler parameters are unreliable for estimating left ventricular (LV) filling pressures in hypertrophic cardiomyopathy (HCM). This study was undertaken to evaluate flow propagation velocity by color M-mode and early diastolic annular velocity (Ea) by tissue Doppler 2 new indices of LV relaxation, combined with mitral E velocity for estimation of filling pressures in HCM. METHODS AND RESULTS Thirty-five HCM patients (52+/-15 years) underwent LV catheterization simultaneously with 2-dimensional and Doppler echocardiography. Pulsed Doppler echocardiography of mitral and pulmonary venous flows was obtained along with flow propagation velocity and Ea. LV preA pressure had weak or no relations with mitral, pulmonary venous velocities and atrial volumes. In contrast, preA pressure related strongly to E velocity/flow propagation velocity (r=0.67; SEE=4) and E/Ea (r=0.76; SEE=3.4). In 17 patients with repeat measurements, preA pressure changes were well detected by measuring E velocity/flow propagation velocity (r=0.68; P=0.01) or E/Ea (r=0.8; P<0.001). PreA pressure estimation with these 2 methods was tested prospectively in 17 additional HCM patients with good results (E velocity/flow propagation velocity, r=0.76; E/Ea, r=0.82). CONCLUSIONS LV filling pressures can be estimated with reasonable accuracy in HCM patients by measuring E velocity/flow propagation velocity or E/Ea. These ratios also track changes in filling pressures.
Effects of intra‐ and extracellular acidifications on single channel Kir2.3 currents

1 The inward rectifier K+ channel Kir2.3 is inhibited by hypercapnia, and this inhibition may be mediated by decreases in intra‐ and extracellular pH. To understand whether Kir2.3 has two distinct pH sensors and whether cytosol‐soluble factors are involved in the modulation of this channel during intracellular acidification, single channel currents were studied by expressing Kir2.3 in Xenopus oocytes. 2 In excised inside‐out patches, Kir2.3 currents had a high baseline channel open‐state probability (Po, at pH 7.4) with a strong inward rectification. Single channel conductance at hyperpolarizing membrane potential was about 17 pS with 150 mM K+ applied to both sides of the membrane. The channel showed a substate conductance of about 8 pS. 3 Reduction of intracellular pH (pHi) produced a fast and reversible inhibition of single channel Kir2.3 currents in inside‐out patches. The extent of this inhibition is concentration dependent. A clear reduction in Kir2.3 currents was seen at pHi 7.0, and channel activity was completely suppressed at pHi 6.2 with mid‐point inhibition (pK) at pH 6.77. 4 The effect of low pHi on Kir2.3 currents was due to a strong inhibition of Po and a moderate suppression of single channel conductance. The pK values for these single channel properties were pH 6.78 and 6.67, respectively. 5 The decrease in Po with low pHi resulted from an increase in the channel mean closed time without significant changes in the mean open time. Substate conductance was not seen during low pHi. 6 Decrease in extracellular pH (pHo) also caused inhibition of single channel activity of Kir2.3 currents in excised outside‐out patches. This effect, however, was clearly different from that of pHi: the pK (pH 6.70) was about 0.1 pH units lower; more than 50 % channel activity was retained at pHo 5.8; and low pHo affected mainly single channel conductance. 7 These results therefore indicate that (1) there are two distinct pH sensors in Kir2.3, (2) different mechanisms are involved in the modulation of Kir2.3 through these two pH sensors, and (3) cytosol‐soluble factors do not appear to be engaged in this modulation.
Efficacy of the Epley Maneuver for Posterior Canal BPPV: A Long-Term, Controlled Study of 81 Patients

We assessed the efficacy of the Epley maneuver (canalith repositioning) in a study of 81 patients with posterior semicircular canal benign paroxysmal positional vertigo (BPPV). A group of 61 patients underwent the maneuver, while a control group of 20 patients received no therapy. All patients were evaluated at 1 and 6 months. The percentage of patients who experienced subjective improvement was significantly higher in the treatment group at both 1 month (89% vs. 10%) and 6 months (92% vs. 50%). Three patients in the treatment group who did not improve after treatment underwent a second maneuver, and all achieved a positive result. In addition, 4 successfully treated patients experienced a recurrence between 1 and 6 months following treatment; 3 were retreated, and 2 of them responded well. We conclude that the Epley maneuver provides effective and long-term control of symptoms in patients with BPPV.
Mutations in the Primer Grip of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impair Proviral DNA Synthesis and Virion Maturation

ABSTRACT This report describes the effects of mutating highly conserved residues in the primer grip domain of human immunodeficiency virus type 1 reverse transcriptase (RT) on virus formation and infectivity. Among a series of RT mutant viruses, three (M230A, L234D, and W239A) were found to be noninfectious or very poorly infectious. Our data indicate that these mutations in RT caused severe defects in proviral DNA synthesis. Interestingly, assembly and maturation of mutant virus M230A were similar to those of the wild type, while mutants L234D and W239A showed impaired maturation. The immature morphology of RT mutants L234D and W239A is due at least in part to premature cleavage of the gag-pol precursor, prior to virion budding, indicating that intracellular stability of Pr160 gag-pol is of key importance during virus assembly.
Towards a theory grounded theory of language

In this paper, we build upon the idea of theory grounding and propose one specific form of theory grounding, a theory of language. Theory grounding is the idea that we can imbue our embodied artificially intelligent systems with theories by modeling the way humans, and specifically young children, develop skills with theories. Modeling theory development promises to increase the conceptual and behavioral flexibility of these systems. An example of theory development in children is the social understanding referred to as "theory of mind. " Language is a natural task for theory grounding because it is vital in symbolic skills and apparently necessary in developing theories. Word learning, and specifically developing a concept of words, is proposed as the first step in a theory grounded theory of language.
Diversity, Community Structure, and Antagonism of Endophytic Fungi from Asymptomatic and Symptomatic Mongolian Pine Trees

Diplodia tip blight, caused by Diplodia sapinea (=Sphaeropsis sapinea), are widely distributed in Honghuaerji, Inner Mongolia, China, causing severe damage on natural Mongolian pine (Pinus sylvestris var. mongolica). D. sapinea is an endophyte that becomes pathogenic under conditions of drought, hail damage, or temperature-associated stress. The role of the endophytic community inhabiting different pine tissues in the expression of disease is still unknown. In this study, the diversity and community structure of endophytic fungi among asymptomatic and symptomatic Mongolian pine were detected using culture-based isolation and high-throughput sequencing (HTS), and the potential antagonistic endophytes against D. sapinea were also screened. The results indicated that 198 and 235 strains of endophytic fungi were isolated from different tissues of symptomatic and asymptomatic Mongolian pine, respectively. D. sapinea was the most common endophyte isolated from the current-year needles and shoots of symptomatic trees, and Diplodia was also the most common in the HTS data. There were no significant differences in the endophytic fungal species richness among asymptomatic and symptomatic trees, but there were differences observed within specific sampled tissues. The ANOSIM analysis confirmed that the endophytic fungi community structure significantly differed between sampling tissues among symptomatic and asymptomatic Mongolian pine. Furthermore, the antagonism study revealed Penicillium fructuariae-cellae with the ability to inhibit the growth of D. sapinea in vitro, and the potential performance of this fungus, acting as biological control agent, was evaluated under greenhouse. Our findings can pave the way to a better understanding of the interactions between D. sapinea, other endophytic fungi and their hosts, and provide helpful information for more efficient disease management strategies.
Validation of CLIGEN Parameter Adjustment Methods for Southeastern Australia and Southwestern Western Australia

AbstractGlobal climate models (GCMs) are usually used for future climate projections. Model output from GCMs needs to be downscaled and stochastic weather generators such as Climate Generator (CLIGEN) are tools to downscale GCM output and to produce synthetic weather sequences that are statistically similar to the observed weather data. Two methods of adjusting CLIGEN parameters were developed to reproduce precipitation sequences for southeastern Australia (SEA), where significant changes in annual precipitation had occurred, and for southwestern Western Australia (SWWA), where the precipitation has shown a significant decreasing trend since the 1920s. The adjustment methods have been validated using observed precipitation data for these regions. However, CLIGEN outputs ultimately will be used as input to other simulation models. The objective of this research was to further validate the methods of CLIGEN parameter adjustment using conceptual hydrological models to simulate streamflow and to compare the s.
Noncoherent Relaying in Energy Harvesting Communication Systems

In energy harvesting (EH) relay networks, the coherent communication requires accurate estimation/tracking of the instantaneous channel state information (CSI) which consumes extra power. As a remedy, we propose two noncoherent EH relaying protocols based on the amplify-and-forward (AF) relaying, namely, power splitting noncoherent AF (PS-NcAF) and time switching noncoherent AF (TS-NcAF), which do not require any instantaneous CSI. We develop a noncoherent framework of simultaneous wireless information and power transfer (SWIPT), embracing PS-NcAF and TS-NcAF in a unified form. For arbitrary M-ary noncoherent frequency-shift keying (FSK) and differential phase-shift keying (DPSK), we derive maximum-likelihood detectors (MLDs) for PS-NcAF and TS-NcAF in a unified form, which involves integral evaluations yet serves as the optimum performance benchmark. To avoid expensive integral computations, we propose a closed-form detector using the Gauss-Legendre approximation, which achieves almost identical performance as the MLD but at substantially lower complexity. These EH-based noncoherent detectors achieve full diversity in Rayleigh fading. Numerical results demonstrate that our proposed PS-NcAF and TS-NcAF may outperform the conventional grid-powered relay system under the same total power constraint. Various insights which are useful for the design of practical SWIPT relaying systems are obtained. Interestingly, PS-NcAF outperforms TS-NcAF in the single-relay case, whereas TS-NcAF outperforms PS-NcAF in the multi-relay case.
Effect of Calcareous Marine Algae Buffer on High-Producing Dairy Cows during Peak Lactation

Simple Summary High-producing dairy cows face an increased risk of subacute ruminal acidosis, which negatively affects the general health, feed intake, and the quantity and quality of milk produced. The aim of this study was to investigate the effect of calcareous marine algae (Lithotamium calcareum)-based rumen content buffer included in total mixed ration, fed to 34 high-producing, peak lactation Holstein dairy cows (group A, n = 17; group B, n = 17). It was hypothesized that through a rumen content buffering effect, buffer would improve feeding behavior, feed intake, rumen function, and performance. Differences between the experimental and control total mixed ration in most parameters under study (feed intake, rumen content acidity, feces composition, milk yield, and milk composition) were statistically insignificant. However, statistically significant differences were noted in the length of eating and chewing epizodes (feeding time; rumination time) between groups. Feed intake was in line with this, although the difference was only numerical and statistically insignificant. This may simply mean that the buffer effects takes some time to show but persists after the buffer withdrawal. One of the reasons for not achieving a significant improvement in other parameters might be that the cows were fed a typical, well-balanced ration that did not induce acidosis. Abstract The aim of the study was to investigate the effect of calcareous marine algae (Lithotamium calcareum)-based rumen content buffer (CMA) included in concentrated feed within total mixed ration (TMR), fed to 34 peak lactation (87–144 days in milk) Holstein dairy cows, randomized into two groups (group A, n = 17; group B, n = 17), wearing collars with accelerometers, and housed a in barn with automatic feed-weigh troughs. During the first phase P1, group A received TMR with CMA (TMR-E) and group B was fed TMR without the buffer (TMR-C). For P2, the treatments in the groups were exchanged. Feed intake, feeding time (FT), rumination time (RT), milk yield, milk composition, and rumen pH were measured by barn technologies, and rumen fluid and feces composition were analyzed in the laboratory. Differences between the TMR-E and TMR-C in most parameters under study were statistically insignificant, except overall FT and RT, which differed significantly between the groups. Group A, feeding at P1 by TMR-E, exhibited higher FT and RT than Group B (202 min/cow/day vs. 184 min/cow/day, and 486 min/cow/day vs. 428 min/cow/day, respectively). The RT significantly increased after switching from TMR-C to TMR-E. This implies that the buffer effect is delayed and persists after the withdrawal. In the group of cows that received control TMR without buffer in the first phase, RT and milk protein content increased significantly in the first week after the addition of buffer.
A generalized methodology for lower-error area-efficient fixed-width multipliers

In this paper, we extend our generalized methodology for designing lower-error area-efficient fixed-width two's-complement multipliers that receive two s-bit numbers and produce an s-bit product. The generalized methodology involving four steps results in several better error-compensation biases. These better error-compensation biases can be easily mapped to lower-error fixed-width multipliers suitable for VLSI realization.
Replacing supervised classification learning by Slow Feature Analysis in spiking neural networks

It is open how neurons in the brain are able to learn without supervision to discriminate between spatio-temporal firing patterns of presynaptic neurons. We show that a known unsupervised learning algorithm, Slow Feature Analysis (SFA), is able to acquire the classification capability of Fisher's Linear Discriminant (FLD), a powerful algorithm for supervised learning, if temporally adjacent samples are likely to be from the same class. We also demonstrate that it enables linear readout neurons of cortical microcircuits to learn the detection of repeating firing patterns within a stream of spike trains with the same firing statistics, as well as discrimination of spoken digits, in an unsupervised manner.
Cambridge university transcription systems for the multi-genre broadcast challenge

We describe the development of our speech-to-text transcription systems for the 2015 Multi-Genre Broadcast (MGB) challenge. Key features of the systems are: a segmentation system based on deep neural networks (DNNs); the use of HTK 3.5 for building DNN-based hybrid and tandem acoustic models and the use of these models in a joint decoding framework; techniques for adaptation of DNN based acoustic models including parameterised activation function adaptation; alternative acoustic models built using Kaldi; and recurrent neural network language models (RNNLMs) and RNNLM adaptation. The same language models were used with both HTK and Kaldi acoustic models and various combined systems built. The final systems had the lowest error rates on the evaluation data.
Natural Exposure of Horses to Mosquito-Borne Flaviviruses in South-East Queensland, Australia

In 2011 an unprecedented epidemic of equine encephalitis occurred in south-eastern (SE) Australia following heavy rainfall and severe flooding in the preceding 2–4 months. Less than 6% of the documented cases occurred in Queensland, prompting the question of pre-existing immunity in Queensland horses. A small-scale serological survey was conducted on horses residing in one of the severely flood-affected areas of SE-Queensland. Using a flavivirus-specific blocking-ELISA we found that 63% (39/62) of horses older than 3 years were positive for flavivirus antibodies, and of these 18% (7/38) had neutralizing antibodies to Murray Valley encephalitis virus (MVEV), Kunjin virus (WNVKUN) and/or Alfuy virus (ALFV). The remainder had serum-neutralizing antibodies to viruses in the Kokobera virus (KOKV) complex or antibodies to unknown/untested flaviviruses. Amongst eight yearlings one presented with clinical MVEV-encephalomyelitis, while another, clinically normal, had MVEV-neutralizing antibodies. The remaining six yearlings were flavivirus antibody negative. Of 19 foals born between August and November 2011 all were flavivirus antibody negative in January 2012. This suggests that horses in the area acquire over time active immunity to a range of flaviviruses. Nevertheless, the relatively infrequent seropositivity to MVEV, WNVKUN and ALFV (15%) suggests that factors other than pre-existing immunity may have contributed to the low incidence of arboviral disease in SE-Queensland horses during the 2011 epidemic.
Effects of Stochasticity in Early Life History on Steepness and Population Growth Rate Estimates: An Illustration on Atlantic Bluefin Tuna

The intrinsic population growth rate (r) of the surplus production function used in the biomass dynamic model and the steepness (h) of the stock-recruitment relationship used in age-structured population dynamics models are two key parameters in fish stock assessment. There is generally insufficient information in the data to estimate these parameters that thus have to be constrained. We developed methods to directly estimate the probability distributions of r and h for the Atlantic bluefin tuna (Thunnus thynnus, Scombridae), using all available biological and ecological information. We examined the existing literature to define appropriate probability distributions of key life history parameters associated with intrinsic growth rate and steepness, paying particular attention to the natural mortality for early life history stages. The estimated probability distribution of the population intrinsic growth rate was weakly informative, with an estimated mean r = 0.77 (±0.53) and an interquartile range of (0.34, 1.12). The estimated distribution of h was more informative, but also strongly asymmetric with an estimated mean h = 0.89 (±0.20) and a median of 0.99. We note that these two key demographic parameters strongly depend on the distribution of early life history mortality rate (M0), which is known to exhibit high year-to-year variations. This variability results in a widely spread distribution of M0 that affects the distribution of the intrinsic population growth rate and further makes the spawning stock biomass an inadequate proxy to predict recruitment levels.