Miracle-dz/UniFAR-FTUs huggingface dataset:
The facilitation of spiritual connection for the First Nations’ people of British Columbia: a critical incident analysis

Limited research has been conducted into First Nations' healing, particularly in the area of First Nations' spiritual connection. First Nations' spiritual connection is perceived to be important from a counselling perspective. The intent of this study was to construct a fairly comprehensive guide of what helps and what hinders spiritual connection among members of British Columbia's (BC's) First Nations, through a First Nations' voice. Eleven adult members of First Nations living in BC were interviewed to obtain information in the form of critical incidents regarding what helps or what hinders spiritual connection. From these interviews, 29 categories were described as what helped or hindered spiritual connection. These are: ceremonial activities, Elder's teachings/guidance, establishing a connection with nature, prayer, family connection, changing thinking, spiritual beliefs, supernatural experiences, residential school, helping others, seeking help, dreams, role model, spiritual practices, self awareness/self acceptance, receiving your name, cultural preservation/ reclamation, sacred object, First Nations' traditional beliefs, alcoholism and drug recovery, visions, establishing social connection, creative activity, philosophy of life, joining organized religion, teachings/guidance, cultural connection/cultural awareness, relationship to the Creator, speaking a traditional First Nations' language. The findings of this study contribute to the field of counselling psychology by providing a reasonably comprehensive scheme of categories and themes that describe, from a First Nations' perspective what facilitates spiritual connection.
Interactions of the hippocampus and non-hippocampal long-term memory systems during learning, remembering, and over time

The hippocampus and non-hippocampal long-term memory systems each have the capacity to learn and express contextual fear memory. How these systems interact during learning and remembering revolves around hippocampal mediated interference, where the hippocampus dominates for both the acquisition and expression of long-term memory. Hippocampal interference during learning can be overcome by modifying learning parameters such that learning is distributed across multiple independent sessions. The standard view of the role of the hippocampus in long-term memory retrieval is that it is temporally limited, where recently acquired memory is dependent on hippocampal function though as a memory ages, dependency is transferred to other memory systems by a process called systems consolidation. Distributed training demonstrates that learning parameters create a memory that is resistant to hippocampal damage. We find little evidence to support temporally based systems consolidation, and present data that supports the view that if the hippocampus is initially involved in learning a memory, it will always be necessary for accurate retrieval of that memory. A critical assessment of the rat literature revealed that initial memory strength, and/or lesion techniques might be responsible for the few studies that report temporally graded retrograde amnesia using contextual fear conditioning. Our experiments designed to directly test these possibilities resulted in flat gradients, providing further evidence that the hippocampus plays a permanent role in long-term memory retrieval. We propose and assess alternatives to the standard model and conclude that a dual store model is most parsimonious within the presented experiments and related literature. Interactions of the hippocampus and non-hippocampal systems take place at the time of learning and remembering, and are persistent over time.
Low Tumor Mitochondrial DNA Content Is Associated with Better Outcome in Breast Cancer Patients Receiving Anthracycline-Based Chemotherapy

Purpose: In this study, we aimed to explore whether low levels of mitochondrial DNA (mtDNA) content in the primary tumor could predict better outcome for breast cancer patients receiving anthracycline-based therapies. We hypothesized that tumor cells with low mtDNA content are more susceptible to mitochondrial damage induced by anthracyclines, and thus are more susceptible to anthracycline treatment. Experimental Design: We measured mtDNA content by a qPCR approach in 295 primary breast tumor specimens originating from two well-defined cohorts: 174 lymph node–positive patients who received adjuvant chemotherapy and 121 patients with advanced disease who received chemotherapy as first-line palliative treatment. The chemotherapy regimens given were either anthracycline-based (FAC/FEC) or methotrexate-based (CMF). Results: In both the adjuvant and advanced settings, we observed increased benefit for patients with low mtDNA content in their primary tumor, but only when treated with FAC/FEC. In multivariable Cox regression analysis for respectively distant metastasis-free survival and progression-free survival, the HR for the FAC/FEC-treated mtDNA low group in the adjuvant setting was 0.46 [95% confidence interval (CI), 0.24–0.89; P = 0.020] and in the advanced setting 0.49 (95% CI, 0.27–0.90; P = 0.022) compared with the FAC/FEC-treated mtDNA high group. We did not observe these associations in the patients treated with CMF. Conclusions: In our two study cohorts, breast cancer patients with low mtDNA content in their primary tumor had better outcome from anthracycline-containing chemotherapy. The frequently observed decrease in mtDNA content in primary breast tumors may be exploited by guiding chemotherapeutic regimen decision making. Clin Cancer Res; 23(16); 4735–43. ©2017 AACR.
The Understanding of Quantifiers in Semantic Dementia: A Single-Case Study

This study investigates the processing of quantifiers in a patient (AM) with semantic dementia. Quantifiers are verbal expressions such as “many” or “a few”, which refer semantically to quantity concepts although lexically they are like non-quantity words. Patient AM presented with preserved understanding of quantifier words and impaired understanding of non-quantifier words of the same frequency. In parallel to this, he showed preserved numerical knowledge and impaired comprehension of the meaning of words, objects, and of linguistic concepts. These results suggest that the neural organization of quantifiers is within the numerical domain as they pattern with numerical concepts rather than linguistic concepts. These data reinforce the evidence that numerical knowledge is functionally distinct from non-numerical knowledge in the semantic system and indicate that the semantic referent rather than the stimulus format is more relevant for semantic processing. This work was supported by grants from the Wellcome Trust. We wish to thank patient AM for his generous participation in this study.
Male Circumcision and STI Acquisition in Britain: Evidence from a National Probability Sample Survey

Background It is well-established that male circumcision reduces acquisition of HIV, herpes simplex virus 2, chancroid, and syphilis. However, the effect on the acquisition of non-ulcerative sexually transmitted infections (STIs) remains unclear. We examined the relationship between circumcision and biological measures of three STIs: human papillomavirus (HPV), Chlamydia trachomatis and Mycoplasma genitalium. Methods A probability sample survey of 15,162 men and women aged 16-74 years (including 4,060 men aged 16-44 years) was carried out in Britain between 2010 and 2012. Participants completed a computer-assisted personal interview, including a computer-assisted self-interview, which asked about experience of STI diagnoses, and circumcision. Additionally, 1,850 urine samples from sexually-experienced men aged 16-44 years were collected and tested for STIs. Multivariable logistic regression was used to calculate adjusted odds ratios (AOR) to quantify associations between circumcision and i) self-reporting any STI diagnosis and ii) presence of STIs in urine, in men aged 16-44 years, adjusting for key socio-demographic and sexual behavioural factors. Results The prevalence of circumcision in sexually-experienced men aged 16-44 years was 17.4% (95%CI 16.0-19.0). There was no association between circumcision and reporting any previous STI diagnoses, and specifically previous chlamydia or genital warts. However, circumcised men were less likely to have any HPV type (AOR 0.26, 95% confidence interval (CI) 0.13-0.50) including high-risk HPV types (HPV-16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and/or 68) (AOR 0.14, 95% CI 0.05-0.40) detected in urine. Conclusions Circumcised men had reduced odds of HPV detection in urine. These findings have implications for improving the precision of models of STI transmission in populations with different circumcision prevalence and in designing interventions to reduce STI acquisition.
Attack-Resistant Location Estimation in Wireless Sensor Networks

Many sensor network applications require sensors' locations to function correctly. Despite the recent advances, location discovery for sensor networks in hostile environments has been mostly overlooked. Most of the existing localization protocols for sensor networks are vulnerable in hostile environments. The security of location discovery can certainly be enhanced by authentication. However, the possible node compromises and the fact that location determination uses certain physical features (e.g., received signal strength) of radio signals make authentication not as effective as in traditional security applications. This article presents two methods to tolerate malicious attacks against range-based location discovery in sensor networks. The first method filters out malicious beacon signals on the basis of the “consistency” among multiple beacon signals, while the second method tolerates malicious beacon signals by adopting an iteratively refined voting scheme. Both methods can survive malicious attacks even if the attacks bypass authentication, provided that the benign beacon signals constitute the majority of the beacon signals. This article also presents the implementation and experimental evaluation (through both field experiments and simulation) of all the secure and resilient location estimation schemes that can be used on the current generation of sensor platforms (e.g., MICA series of motes), including the techniques proposed in this article, in a network of MICAz motes. The experimental results demonstrate the effectiveness of the proposed methods, and also give the secure and resilient location estimation scheme most suitable for the current generation of sensor networks.
Tumor Survivin Is Downregulated by the Antisense Oligonucleotide LY2181308: A Proof-of-Concept, First-in-Human Dose Study

Purpose: Enhanced tumor cell survival through expression of inhibitors of apoptosis (IAP) is a hallmark of cancer. Survivin, an IAP absent from most normal tissues, is overexpressed in many malignancies and associated with a poorer prognosis. We report the first-in-human dose study of LY2181308, a second-generation antisense oligonucleotide (ASO) directed against survivin mRNA. Patients and Methods: A dose-escalation study evaluating the safety, pharmacokinetics, and pharmacodynamics of LY2181308 administered intravenously for 3 hours as a loading dose on 3 consecutive days and followed by weekly maintenance doses. Patients were eligible after signing informed consent, had exhausted approved anticancer therapies and agreed to undergo pre- and posttreatment tumor biopsies to evaluate reduction of survivin protein and gene expression. Results: A total of 40 patients were treated with LY2181308 at doses of 100 to 1,000 mg. Twenty-six patients were evaluated at the recommended phase 2 dose of 750 mg, at which level serial tumor sampling and [11C]LY2183108 PET (positron emission tomography) imaging demonstrated that ASO accumulated within tumor tissue, reduced survivin gene and protein expression by 20% and restored apoptotic signaling in tumor cells in vivo. Pharmacokinetics were consistent with preclinical modeling, exhibiting rapid tissue distribution, and terminal half-life of 31 days. Conclusions: The tumor-specific, molecularly targeted effects demonstrated by this ASO in man underpin confirmatory studies evaluating its therapeutic efficacy in cancer.
Deuterated hydrogen molecule and search for early structure‐formation signatures in the Universe

Possible detection of signatures of structure formation at the end of the 'dark age' epoch (z ∼ 40-20) is examined. We discuss the spectral-spatial fluctuations in the cosmic microwave background radiation (CMBR) temperature produced by elastic resonant scattering of CMBR photons on deuterated hydrogen (HD) molecules located in protostructures moving with peculiar velocity. Detailed chemical kinematic evolution of HD molecules in the expanding homogeneous medium is calculated. Then, the HD abundances are linked to protostructures at their maximum expansion, whose properties are estimated by using the top-hat spherical approach and the A cold dark matter (ACDM) cosmology. We find that the optical depths in the HD three lowest pure rotational lines for high-peak protohaloes at their maximum expansion are much higher than those in LiH molecule. The corresponding spectral-spatial fluctuation amplitudes, however, are probably too weak to be detected by current and forthcoming millimetre telescope facilities. We extend our estimates of spectral-spatial fluctuations to gas clouds inside collapsed CDM haloes by using results from a crude model of HD production in these clouds. The fluctuations for the highest peak CDM haloes at redshifts ∼20-30 could be detected in the future. Observations will be important to test model predictions of early structure formation in the Universe.
Real-time detection of faces in video streams

This paper describes a face detection system which goes beyond traditional approaches normally designed for still images. First the video stream context is considered to apply the detector, and therefore, the resulting system is designed taking into consideration a main feature available in a video stream, i.e. temporal coherence. The resulting system builds a feature based model for each detected face, and searches them using various model information in the next frame. The results achieved for video stream processing outperform Rowley-Kanade's and Viola-Jones' solutions providing eye and face data in a reduced time with a notable correct detection rate.
Weekend admissions as an independent predictor of mortality: an analysis of Scottish hospital admissions

Objectives Weekend admissions have been shown to be associated with an increased risk of mortality compared with weekday admissions for many diagnoses. We analysed emergency department admissions within the Scottish National Health Service to investigate whether mortality is increased in case of weekend emergency department admissions. Design A cohort study. Setting Scotland National Health Service (NHS) emergency departments. Participants 5 271 327 emergency department admissions between 1999 and 2009. We included all patients admitted via emergency departments recorded in the Scottish Morbidity Records (SMR01) in NHS, Scotland for whom complete demographic data were available. Primary outcome measures Death as recorded by the General Register Office (GRO). Results There was a significantly increased probability of death associated with a weekend emergency admission compared with admission on a weekday (unadjusted OR 1.27, 95% CI 1.26 to 1.28, p<0.0001; adjusted for year of admission, gender, age, deprivation quintile and number of comorbidities OR 1.42, 95% CI 1.40 to 1.43, p<0.0001). Conclusions Despite a general reduction in mortality over the last 11 years, there is still a significant excess mortality associated with weekend emergency admissions. Further research should be undertaken to identify the precise mechanisms underlying this effect so that measures can be put in place to reduce patient mortality.
Links between depressive symptoms and unmet health and social care needs among older prisoners

Background: absolute numbers of older prisoners and their proportion of the total prison population are increasing. They have multiple health and social care needs that are prominent on entry into prison. No previous studies have identified older prisoners' health and social care needs at this crucial point. Objective: to examine unmet health and social care needs among older men entering prison and their links with depressive symptoms. Methods: a cross-sectional survey across nine prisons in the North of England was completed. One hundred male prisoners aged between 60 and 81 were interviewed, using the Camberwell Assessment of Need—Forensic short version (CANFOR-S) and Geriatric Depression Scale—Short Form (GDS-15). Descriptive statistics were generated and χ2 tests performed. Results: participants reported high levels of unmet needs as measured with the CANFOR-S, notably in the domains of knowledge about their condition and treatment (38%); psychological distress (34%); daytime activities (29%); benefits (28%); food (22%) and physical health (21%). The mean total number of unmet needs was 2.74, with a median of 2.0. More than half the sample (56%, 95% CI 45–66%) exhibited clinical signs of depression. A significant association between depressive symptomology and an unmet physical health need, as measured by the CANFOR-S, was detected (χ2 = 6.76, df = 1, P < 0.01). Conclusions: high levels of depressive symptoms were experienced by older prisoners on entry into prison. Personalised health and social care needs assessment and discrete depression screening are required on prison entry to facilitate effective management of unmet needs.
Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV

Objective:An epidemic of acute hepatitis C virus (HCV) infection among HIV-positive men who have sex with men is occurring in urban centers in Western Europe and the United States. Early diagnosis and treatment of HCV results in improved sustained virological response rates. This study compared the sensitivity of reverse transcriptase PCR (RT–PCR) versus antibody screening for the diagnosis of early HCV infection in HIV-positive patients and estimated the length of time from HCV infection to the development of anti-HCV antibodies. Design:Patients from the St Mary's Acute Hepatitis C Cohort (SMACC) were recruited retrospectively and prospectively between 2004 and 2008. Methods:Archived plasma samples, obtained at 1–3 monthly intervals for routine monitoring of HIV viral load were assayed retrospectively for HCV in order to assess the sensitivity of RT–PCR and enzyme-linked immunosorbent assay (ELISA). Results:Forty-three HIV-positive patients with early HCV infection were identified. The median CD4 cell count was 570 cells/μl. The median alanine transaminase at the time of the first positive HCV PCR was 65 IU/ml. At this time, 75% of patients had a negative HCV antibody test. Three months later, 37% of patients still had a negative result. After 9 months, 10% of patients had a negative test and 5% remained negative after 1 year. Conclusion/discussion:Delayed seroconversion in HIV-positive individuals with acute HCV may result in delayed diagnosis and treatment. Where there is a clinical suspicion of recent HCV infection, for example, elevated alanine transaminase levels, HIV-infected patients should be screened for HCV RNA by RT–PCR.
G-quadruplex secondary structure from circular dichroism spectroscopy

A curated library of circular dichroism spectra of 23 G-quadruplexes of known structure was built and analyzed. The goal of this study was to use this reference library to develop an algorithm to derive quantitative estimates of the secondary structure content of quadruplexes from their experimental CD spectra. Principle component analysis and singular value decomposition were used to characterize the reference spectral library. CD spectra were successfully fit to obtain estimates of the amounts of base steps in anti-anti, syn-anti or anti-syn conformations, in diagonal or lateral loops or in other conformations. The results show that CD spectra of nucleic acids can be analyzed to obtain quantitative structural information about secondary structure content in an analogous way to methods used to analyze protein CD spectra.
ComProLab: A Component Programming Laboratory

We present here an approach to component programming which defines languages and tools at both the product and the process levels. At the product level, we allow the use of already existing languages to write functional specifications and implementations of components; also, we provide a notation to state their non-functional specifications, which involve operational attributes as efficiency. Functional specifications can be employed to perform prototyping in a mixed execution framework, which allows the combination of algebraic specifications and imperative code, while non-functional specifications are used to select automatically the best implementation of every component appearing in a software system. At the process level, we have introduced a set of basic program development tasks and we have defined a process language to formulate software process models as particular combinations of these tasks. A process assistant can be used to guide software development following any model defined with this language.
Culturally prescribed beliefs about mental illness among the Akan of Ghana

Mental illness is a culturally laden phenomenon, and different cultures have unique ways of constructing mental illness. In this study, conceptions of mental illness were explored among 30 participants of Akan descent in Ghana through individual and group interviews. Participants demonstrated a wide range of knowledge on mental illness indicating that poor self-care, deficits in social functioning, and disordered behaviors are the cardinal features of mental illness. The data revealed that Akan cultural beliefs influenced notions of etiology of mental illness and care of the mentally ill. While participants recognized the role of multiple factors such as genetics, substance abuse, daily hassles (for example, concerns about basic needs such as food, clothing, and shelter), and trauma in the cause of mental illness, the predominant belief was that mental illness is a retributive and/or a spiritual illness. This belief encourages pluralistic health-seeking behaviors: use of hospitals, prayer camps, herbalists, and traditional healers. The implications of these findings for public health education on mental illness, and clinical training and practice are discussed.
Patterns of convection in rotating spherical shells

Patterns of convection in internally heated, self-gravitating rotating spherical fluid shells are investigated through numerical simulations. While turbulent states are of primary interest in planetary and stellar applications the present paper emphasizes more regular dynamical features at Rayleigh numbers not far above threshold which are similar to those which might be observed in laboratory or space experiments. Amplitude vacillations and spatial modulations of convection columns are common features at moderate and large Prandtl numbers. In the low Prandtl number regime equatorially attached convection evolves differently with increasing Rayleigh number and exhibits an early transition into a chaotic state. Relationships of the dynamical features to coherent structures in fully turbulent convection states are emphasized.