Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines

In the present pilot study, we examined the presence of serglycin in lung, breast, prostate, and colon cancer and evaluated its expression in cell lines and tissues. We found that serglycin was expressed and constitutively secreted in culture medium in high levels in more aggressive cancer cells. It is worth noticing that aggressive cancer cells that harbor KRAS or EGFR mutations secreted serglycin constitutively in elevated levels. Furthermore, we detected the transcription of an alternative splice variant of serglycin lacking exon 2 in specific cell lines. In a limited number of tissue samples analyzed, serglycin was detected in normal epithelium but was also expressed in higher levels in advanced grade tumors as shown by immunohistochemistry. Serglycin staining was diffuse, granular, and mainly cytoplasmic. In some cancer cells serglycin also exhibited membrane and/or nuclear immunolocalization. Interestingly, the stromal cells of the reactive tumor stroma were positive for serglycin, suggesting an enhanced biosynthesis for this proteoglycan in activated tumor microenvironment. Our study investigated for first time the distribution of serglycin in normal epithelial and cancerous lesions in most common cancer types. The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression.
Evaluation of a Removable Intraoral Soft Stabilization Splint for the Reduction of Headaches and Nightmares in Military PTSD Patients: A Large Case Series.

This large case series reports the results of using a removable soft intraoral stabilization splint in the treatment of chronic headaches and chronic nightmares in 60 military post-traumatic stress disorder (PTSD) patients of the Vietnam, Desert Storm, Operation Iraqi Freedom, and Operation Enduring Freedom conflicts. Patient treatment criteria included meeting all of the following requirements: minimum of three headaches per week; minimum of three nightmares per week; minimum of three sleep interruptions per week; minimum of three intraoral or extraoral (craniofacial) trigger points; and previous PTSD diagnosis by the U.S. Army or Veterans Administration with duration of this disorder for a minimum of three years. Significant reduction (60%? 90%) in headache and nightmare severity, intensity, and duration was obtained in 75% of the 44 patients who completed the three-month follow-up.
Rheumatoid rosette in juvenile rheumatoid arthritis

The rheumatoid rosette test was performed in 159 children. Positive results were found more frequently in juvenile rheumatoid arthritis when more than four joints were involved. It is not to be considered as a diagnostic test since `false positive' tests occur in other diseases. The immunological significance of the rosette test is discussed.
Variation and recent change in fingerspelling in British Sign Language

ABSTRACT British Sign Language is a language exhibiting extensive regional variation and undergoing rapid change, in a period of changing attitudes to the language and the community of signers. Fingerspelling (a representation of written English) is an aspect of BSL that reflects these variations strongly. Analysis of interviews with Deaf signers appearing on BBC television shows that use of fingerspelling may vary according to various demographic factors and the signers' use of voice. There has also been a decrease in the overall use of fingerspelling in BSL over the last 10 years. Strong evidence is presented to support the claim that fingerspelling in BSL is of two distinct linguistic types. Some fingerspelling involves code-mixing with English, whereas some has become incorporated into the language itself. Further evidence for such a “discontinuity” between the code-mixing and borrowing is presented and discussed.
Explaining Girls’ Advantage in Kindergarten Literacy Learning: Do Classroom Behaviors Make a Difference?

This study investigated gender differences in kindergarteners’ literacy skills, specifically, whether differences in children’s classroom behaviors explained females’ early learning advantage. Data included information on 16,883 kindergartners (8,701 boys and 8,182 girls) from the Early Childhood Longitudinal Study, Kindergarten Cohort of 1998–1999 (ECLS‐K). The ECLS‐K directly assessed children’s cognitive skills and collected extensive data on children’s sociodemographic and behavioral backgrounds through structured telephone interviews with parents and written surveys with children’s teachers. Findings suggested that not only did girls enter kindergarten with somewhat stronger literacy skills but they also learned slightly more than boys over the kindergarten year. Taking into account teachers’ reports of girls’ more positive learning approaches (e.g., attentiveness, task persistence) explained almost two‐thirds of the female advantage in literacy learning. Accounting for boys’ more prevalent external behavior problems, thought by many to explain girls’ advantage in literacy development, did little to diminish the gender gap.
From Theory to Practice: The Development of Assessment Guides from Qualitatively Derived Theory

In this article, a method of using qualitative research findings to develop a patient assessment guide is described. Qualitatively derived theory is deconstructed to form the theoretical components of the guide. Nursing assessment questions and behavioral signs are then elicited from the theory. Intervention strategies are extrapolated both from theory and from clinical nursing knowledge. Finally, the assessment guide is implemented and evaluated using techniques of qualitative outcome analysis to modify the guide and expand the repertoire of intervention strategies. This process is illustrated using two projects: hope (from concept analysis) and living with bipolar disorders (from grounded theory). Assessment guides provide a method for directly applying qualitative research to practice and constitute a valid and useful means of patient assessment and intervention.
Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels.

BACKGROUND Despite a large body of clinical and histological data demonstrating beneficial effects of enamel matrix proteins (EMPs) for regenerative periodontal therapy, it is less clear how the available biological data can explain the mechanisms underlying the supportive effects of EMPs. OBJECTIVE To analyse all available biological data of EMPs at the cellular and molecular levels that are relevant in the context of periodontal wound healing and tissue formation. METHODS A stringent systematic approach was applied using the key words "enamel matrix proteins" OR "enamel matrix derivative" OR "emdogain" OR "amelogenin". The literature search was performed separately for epithelial cells, gingival fibroblasts, periodontal ligament cells, cementoblasts, osteogenic/chondrogenic/bone marrow cells, wound healing, and bacteria. RESULTS A total of 103 papers met the inclusion criteria. EMPs affect many different cell types. Overall, the available data show that EMPs have effects on: (1) cell attachment, spreading, and chemotaxis; (2) cell proliferation and survival; (3) expression of transcription factors; (4) expression of growth factors, cytokines, extracellular matrix constituents, and other macromolecules; and (5) expression of molecules involved in the regulation of bone remodelling. CONCLUSION All together, the data analysis provides strong evidence for EMPs to support wound healing and new periodontal tissue formation.
Initiate, Create, Activate: Practical Solutions for Making Culturally Diverse Music Education a Reality.

Cross-cultural music education can motivate children to look at music in fresh ways and awaken their imagination to new possibilities and ways of thinking. This paper presents the voices of three practitioners experienced in, and passionate about the field of culturally diverse music education. Over the past 25 years the presenters have ignited an interest in world musics in their students from pre-school to higher education in North America, Asia, Australia and the Middle East. They have been committed to creating innovative programs which practically reflect the changing nature of contemporary classrooms within a global society. The paper provides a review of the current state of culturally diverse music education in North America and Australia - exploring underlying philosophical constructs, prevailing attitudes and current teacher training experiences - as a theoretical framework for a practical 'how to' guide for school teachers; tried and tested with a wide variety of ages, and in an abundance of contexts. Themes discussed include the role of diverse musical experiences in creative expression, and the critical role individual music educators play in assisting students to develop qualities of curiosity, open-mindedness and a 'tolerance of uncertainty'. Factors conducive to successful multicultural music programs and a contextual themes framework will provide readers with knowledge and skills to spark interest in world musics in their students.
The relationship between work characteristics and employee health and well-being: how much complexity do we really need?

In comparison with R. A. Karasek and T. Theorell's (1990) well-known demand-control-support (DCS) model, recent models of the effects of work characteristics on employee health and well-being are complex in regard to the number of characteristics included, the specificity of the relationships, and the situational specificity assumed. Data from 37,291 Dutch employees were used to examine to what extent these 3 approaches are valid. Several increasingly complex models of the relations among 7 work characteristics were compared and cross validated in 4 branches of industry. Further, these work characteristics were related to 3 outcome variables. A general model—tentatively labeled the demand-skill-support model—provided the best approximation of the relationships among work characteristics, health, and well-being.
Online Communication and Adolescent Relationships

Over the past decade, technology has become increasingly important in the lives of adolescents. As a group, adolescents are heavy users of newer electronic communication forms such as instant messaging, e-mail, and text messaging, as well as communication-oriented Internet sites such as blogs, social networking, and sites for sharing photos and videos. Kaveri Subrahmanyam and Patricia Greenfield examine adolescents' relationships with friends, romantic partners, strangers, and their families in the context of their online communication activities.The authors show that adolescents are using these communication tools primarily to reinforce existing relationships, both with friends and romantic partners. More and more they are integrating these tools into their "offline" worlds, using, for example, social networking sites to get more information about new entrants into their offline world.Subrahmanyam and Greenfield note that adolescents' online interactions with strangers, while not as common now as during the early years of the Internet, may have benefits, such as relieving social anxiety, as well as costs, such as sexual predation. Likewise, the authors demonstrate that online content itself can be both positive and negative. Although teens find valuable support and information on websites, they can also encounter racism and hate messages. Electronic communication may also be reinforcing peer communication at the expense of communication with parents, who may not be knowledgeable enough about their children's online activities on sites such as the enormously popular MySpace.Although the Internet was once hailed as the savior of education, the authors say that schools today are trying to control the harmful and distracting uses of electronic media while children are at school. The challenge for schools is to eliminate the negative uses of the Internet and cell phones in educational settings while preserving their significant contributions to education and social connection.
Efficient Multi-label Classification with Many Labels

In multi-label classification, each sample can be associated with a set of class labels. When the number of labels grows to the hundreds or even thousands, existing multi-label classification methods often become computationally inefficient. In recent years, a number of remedies have been proposed. However, they are based either on simple dimension reduction techniques or involve expensive optimization problems. In this paper, we address this problem by selecting a small subset of class labels that can approximately span the original label space. This is performed by an efficient randomized sampling procedure where the sampling probability of each class label re flects its importance among all the labels. Experiments on a number of real-world multi-label data sets with many labels demonstrate the appealing performance and efficiency of the proposed algorithm.
Using Flashcard Drill Methods and Self-Graphing Procedures to Improve the Reading Performance of English Language Learners

The increasing numbers of English language learners who are enrolled in schools across the nation, combined with the escalating academic demands placed on all students, warrant the evaluation of instructional strategies designed to improve English language learners’ reading performance. In this study, the authors used a multiple baseline design across individuals to examine the effects of an intervention that combined (a) a vocabulary folding-in technique and (b) self-graphing procedures on the reading performance of 3 third-grade Spanish-speaking English language learners. Curriculum-based measurement oral reading fluency and reading comprehension probes were implemented to monitor the students’ reading progress. Results indicated that the combined intervention improved the participants’ reading performance as measured by vocabulary sight words, reading fluency, and reading comprehension tasks. Implications of this research, including how school psychologists can use interventions such as these to serve as interventionists, are discussed.
Hospital Anxiety and Depression Scale, Deutsche Version (HADS-D)

Es handelt sich um ein rasch zu bearbeitendes Selbstbeurteilungsverfahren, das aus je sieben Angstund Depressionsfragen besteht: Die HADS-D kann als Screening und zur Verlaufsbeurteilung ab 15 Jahren eingesetzt werden. Im deutschen Sprachraum liegt jetzt eine aktualisierte und mit neuen Normen (aus der Allgemeinbevolkerung) ausgestattete, dritte Auflage vor (Herrmann-Lingen, Buss & Snaith, 2011).
Immigrants and homelessness—at risk in Canada's outer suburbs

Homelessness is a risk for growing numbers of immigrants. Largely as a result of low incomes, newcomers are more likely than the Canadian-born to spend over 50 percent of total household income on housing costs. Many newcomers suffer ‘hidden homelessness’. They do not use shelters and other services, but share accommodation, couch-surf and rely on their social contacts for temporary and precarious housing. The adverse impact of low incomes on the housing experiences of Canadian newcomers is exacerbated in the outer suburbs of metropolitan areas where the supply of affordable housing is limited. This study explores the social backgrounds and housing experiences of immigrant households that are vulnerable to homelessness in outer suburbs through analysis of special tabulations from the 2001 census for York Region and interviews with representatives from local community organisations serving immigrant and low-income populations. The initial findings confirm that a high proportion of newcomers in York Region are at-risk of homelessness during the first 10 years of residence in Canada. Although renters are more vulnerable than homeowners, a substantial percentage of newcomers who are homeowners pay more than 30 percent of their total income on housing costs. The shortage of affordable rental housing in the outer suburbs exacerbates the impacts of low incomes, immigration status, household size and ethnoracial identities on immigrants' housing.
Morphogenesis and pathogenicity of Histoplasma capsulatum

The sulfhydryl blocking agent p-chloromercuriphenylsulfonic acid (PCMS) irreversibly inhibited the mycelium-to-yeast transitions of two virulent strains of Histoplasma capsulatum, G184A and G222B, when the temperature of incubation was raised to 37 degrees C, and the block persisted even after the cultures were washed free of PCMS. Instead of transforming to yeast cells, PCMS-treated mycelia continued to grow as mycelia at the elevated temperatures. A less virulent strain (Downs) was more temperature sensitive, but it showed a similar irreversible effect at 34 degrees C. Therefore, the mycelium-to-yeast transition of H. capsulatum is not required for the adaptation of mycelia to elevated temperatures but probably results from the temperature-dependent activation of yeast-specific genes. The transition to yeast is inferred to be obligate for pathogenicity in mice because PCMS-treated mycelia failed to cause infection, and no fungi were seen in tissues after PCMS-treated mycelia were injected into mice.
‘The emergency which has arrived’: the problematic history of nineteenth-century British algebra – a programmatic outline

More than any other aspect of the Second Scientific Revolution, the remarkable revitalization or British mathematics and mathematical physics during the first half of the nineteenth century is perhaps the most deserving of the name. While the newly constituted sciences of biology and geology were undergoing their first revolution, as it were, the reform of British mathematics was truly and self-consciously the story of a second coming of age. ‘Discovered by Fermat, cocinnated and rendered analytical by Newton, and enriched by Leibniz with a powerful and comprehensive notation’, wrote the young John Herschel and Charles Babbage of the calculus in 1813, ‘as if the soil of this country [was] unfavourable to its cultivation, it soon drooped and almost faded into neglect; and we now have to re-import the exotic, with nearly a century of foreign improvement, and to render it once more indigenous among us’.
Leadership in context: investigating hierarchical impacts on transformational leadership

Purpose – The purpose of this paper is to empirically investigate hierarchical impacts on specific transformational leadership (TFL) behaviors (i.e. idealized influence, inspirational motivation, intellectual stimulation, and individualized consideration). Design/methodology/approach – Survey data on TFL, job satisfaction, and hierarchy were collected from 448 managers from a multinational corporation in Sweden.Findings – Idealized influence and inspirational motivation occurred more frequently among upper rather than middle managers, while there were no differences for intellectual stimulation and individualized consideration. Also, idealized influence, inspirational motivation, and intellectual stimulation were more effective in strengthening subordinates' job satisfaction among upper rather than middle managers, while individualized consideration was similarly effective in both groups.Research limitations/implications – The cross‐sectional research design precludes causal conclusions and potentially all.
Immunosuppressive Activity of Endovanilloids: N-Arachidonoyl-Dopamine Inhibits Activation of the NF-κB, NFAT, and Activator Protein 1 Signaling Pathways 1

Endogenous N-acyl dopamines such as N-arachidonoyldopamine (NADA) and N-oleoyldopamine have been recently identified as a new class of brain neurotransmitters sharing endocannabinoid and endovanilloid biological activities. As endocannabinoids show immunomodulatory activity, and T cells play a key role in the onset of several diseases that affect the CNS, we have evaluated the immunosuppressive activity of NADA and N-oleoyldopamine in human T cells, discovering that both compounds are potent inhibitors of early and late events in TCR-mediated T cell activation. Moreover, we found that NADA specifically inhibited both IL-2 and TNF-α gene transcription in stimulated Jurkat T cells. To further characterize the inhibitory mechanisms of NADA at the transcriptional level, we examined the DNA binding and transcriptional activities of NF-κB, NF-AT, and AP-1 transcription factors in Jurkat cells. We found that NADA inhibited NF-κB-dependent transcriptional activity without affecting either degradation of the cytoplasmic NF-κB inhibitory protein, IκBα, or DNA binding activity. However, phosphorylation of the p65/RelA subunit was clearly inhibited by NADA in stimulated cells. In addition, NADA inhibited both binding to DNA and the transcriptional activity of NF-AT and AP-1, as expected from the inhibition of NF-AT1 dephosphorylation and c-Jun N-terminal kinase activation in stimulated T cells. Finally, overexpression of a constitutively active form of calcineurin demonstrated that this phosphatase may represent one of the main targets of NADA. These findings provide new mechanistic insights into the anti-inflammatory activities of NADA and highlight their potential to design novel therapeutic strategies to manage inflammatory diseases.
Creating Social Identities through Narratives

This study describes narrative activity in a doctrina class (children's religious education class in Spanish) composed of Mexican immigrants at a Catholic parish in Los Angeles. During the telling of the narrative of the apparition of Nuestra Senora de Guadalupe (Our Lady of Guadalupe) doctrina students and their teacher collaboratively construct a multiplicity of identities in an ongoing narrative version. These past and present identities are represented as Mexican, de aqui (from here), and dark-skinned against the backdrop of the description of an oppressive colonial past in Mexico. The paper compares a doctrina class with a racially mixed religious education class conducted in English (catechism) at the same parish to illustrate differences in the way social identities are created in both classes.