Miracle-dz/UniFAR-FTUs huggingface dataset:
Sputum IgE and Cytokines in Asthma: Relationship with Sputum Cellular Profile

Background Local IgE production may play a role in asthma pathogenesis. The aim of the study was to assess sputum total IgE and cytokines in asthmatics according to sputum cellular phenotype. Methods We studied 122 subjects including 22 non atopic healthy subjects, 41 eosinophilic (sputum eosinophils ≥3%), 16 neutrophilic (sputum neutrophils >76%) and 43 pauci-granulocytic asthmatics (sputum eosinophils <3% and sputum neutrophils ≤76%) recruited from the asthma clinic at CHU Liege. Sputum supernatant total IgE (tIgE) was measured by ImmunoCAP and sputum supernatant cytokines (IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, IFN-γ and TNF-α) were measured with the Luminex xMAP Technology by using commercially available Fluorokine MAP kits. Results After concentrating sputum samples, total IgE was detectable in the majority of subjects. Sputum IgE was raised in asthmatics when compared to healthy subjects. Overall, asthmatics did not significantly differ from healthy subjects with respect to cytokine levels. The eosinophilic asthma phenotype, however, was characterised by raised sputum tIgE, IL-5 and IL-13 compared to healthy subjects (p<0.001, p<0.001 and p<0.05 respectively) and pauci-granulocytic asthma (p<0.01, p<0.001 and p<0.05 respectively) and raised IL-5 compared to neutrophilic asthma (p<0.01). When patients were classified according to sputum IgE levels, it appeared that IL-5, IL-6, IL-17 and TNF-α sputum supernatant levels were raised in the “IgE high” asthmatics (IgE ≥0.1 kU/l) when compared to “IgE low” asthmatics (IgE<0.1 kU/l). Conclusion The eosinophilic asthma phenotype was associated with raised sputum IgE and a Th2 cytokine profile. Raised sputum IgE was associated with a heterogeneous cytokine overproduction.
Weighted and Probabilistic Context-Free Grammars Are Equally Expressive

This article studies the relationship between weighted context-free grammars (WCFGs), where each production is associated with a positive real-valued weight, and probabilistic context-free grammars (PCFGs), where the weights of the productions associated with a nonterminal are constrained to sum to one. Because the class of WCFGs properly includes the PCFGs, one might expect that WCFGs can describe distributions that PCFGs cannot. However, Z. Chi (1999, Computational Linguistics, 25(1):131160) and S. P. Abney, D. A. McAllester, and P. Pereira (1999, In Proceedings of the 37th Annual Meeting of the Association for Computational Linguistics, pages 542549, College Park, MD) proved that every WCFG distribution is equivalent to some PCFG distribution. We extend their results to conditional distributions, and show that every WCFG conditional distribution of parses given strings is also the conditional distribution defined by some PCFG, even when the WCFG's partition function diverges. This shows that any parsing or labeling accuracy improvement from conditional estimation of WCFGs or conditional random fields (CRFs) over joint estimation of PCFGs or hidden Markov models (HMMs) is due to the estimation procedure rather than the change in model class, because PCFGs and HMMs are exactly as expressive as WCFGs and chain-structured CRFs, respectively.
Assessment of Circulating microRNAs in Plasma of Lung Cancer Patients

Lung cancer is the most common cause of cancer deaths worldwide and numerous ongoing research efforts are directed to identify new strategies for its early detection. The development of non-invasive blood-based biomarkers for cancer detection in its preclinical phases is crucial to improve the outcome of this deadly disease. MicroRNAs (miRNAs) are a new promising class of circulating biomarkers for cancer detection and prognosis definition, but lack of consensus on data normalization methods for circulating miRNAs and the critical issue of haemolysis, has affected the identification of circulating miRNAs with diagnostic potential. We describe here an interesting approach for profiling circulating miRNAs in plasma samples based on the evaluation of reciprocal miRNA levels measured by quantitative Real-Time PCR. By monitoring changes of plasma miRNA-ratios, it is possible to assess the deregulation of tumor-related miRNAs and identify signatures with diagnostic and prognostic value. In addition, to avoid bias due to the release of miRNAs from blood cells, a miRNA-ratios signature distinguishing haemolyzed samples was identified. The method described was validated in plasma samples of lung cancer patients, but given its reproducibility and reliability, could be potentially applied for the identification of diagnostic circulating miRNAs in other diseases.
On the Effect of Blockage Objects in Dense MIMO SWIPT Networks

Simultaneous wireless information and power transfer (SWIPT) is characterized by the ambiguous role of multi-user interference. In short, the beneficial effect of multi-user interference on RF energy harvesting is obtained at the price of a reduced link capacity, thus originating nontrivial tradeoffs between the achievable information rate and the harvestable energy. Arguably, in indoor environments, this tradeoff might be affected by the propagation loss due to blockage objects like walls. Hence, a couple of fundamental questions arise. How much must the network elements be densified to counteract the blockage attenuation? Is blockage always detrimental on the achievable rate-energy tradeoff? In this paper, we analyze the performance of an indoor multiple-input multiple-output SWIPT-enabled network in the attempt to shed a light of those questions. The effects of the obstacles are examined with the help of a stochastic geometry approach in which the locations of energy sources (also referred to as power heads) are distributed by using a Poisson point process and walls are generated through a Manhattan Poisson line process. The stochastic behavior of the signal attenuation and the multi-user interference is studied to obtain the joint complementary cumulative distribution function of information rate and harvested power. Theoretical results are validated through Monte Carlo simulations. Eventually, the rate-energy tradeoff is presented as a function of the density of walls to emphasize the cross-dependences between the deployment of the network elements and the macro parameters characterizing the topology of the venue.
Occupations and exposures in the work environment as determinants for rheumatoid arthritis

Background and Aims: Several occupational categories have been associated with rheumatoid arthritis (RA); this study was conducted to further evaluate these associations. Methods: Lifelong occupational history together with exposure experiences were collected through a postal questionnaire answered by 293 incident cases and 1346 population based referents. Occupational determinants were evaluated through stratified and multivariate analyses; pooled analyses with previously gathered data on 422 prevalent cases and 858 referents were also performed. Results: In both materials, significantly increased logistic odds ratios (LORs) were seen for male conductors, freight and transport workers (LOR 17.8, 95% CI 1.5 to 207.8 and LOR 4.7, 95% CI 1.4 to 16.3, respectively), and farmers and farm workers (LOR 2.4, 95% CI 1.1 to 5.2, and LOR 2.2, 95% CI 1.3 to 3.5, respectively). Among women, increased LORs were seen in the separate and the pooled material for printmakers and process engravers (LOR 5.5, 95% CI 0.9 to 32.6, and LOR 3.0, 95% CI 0.9 to 10.3, respectively). Increased risks were seen in both materials for men exposed to asbestos (LOR 2.5, 95% CI 1.0 to 6.8, and LOR 1.6, 95% CI 0.8 to 3.3, respectively), and vibrations (LOR 2.0, 95% CI 0.9 to 4.4, and LOR 2.2, 95% CI 1.3 to 3.8, respectively). The risk for RA increased with increasing duration of exposure to vibrations and mineral dust, respectively. Conclusions: There was evidence of a causal relation between exposures to vibrations and mineral dust and development of RA among men. Occupational factors seem to be aetiologically more important for men, and most occupations at risk involve multiple exposures. Several exposures associated with an increased risk for RA are frequent among farmers, and some of the occupations at risk include exposure to organic dust.
Does theWorld Economy Swing National Elections ? Å

Do voters reward national leaders who are more competent economic managers, or merely those who happen to be in power when the world economy booms? Using data from 268 democratic elections held between 1978 and 1999, I compare the effect of world growth (luck) and national growth relative to world growth (competence). Both matter, but the effect of luck is larger than the effect of competence. Voters are more likely to reward competence in countries that are richer and better educated; and there is some suggestive evidence that media penetration rates affect the returns to luck and competence.
Feeding Study with Bt Corn (MON810: Ajeeb YG) on Rats: Biochemical Analysis and Liver Histopathology

Bt corn “MON810: Ajeeb YG” produces delta endotoxins in the whole plant due to the genetic modification process. The chemical analysis of this variety showed significant differences from its conventional counterpart “Ajeeb”. Further, feeding studies on rats were designed to complete assessing the safety of “MON810: Ajeeb YG”. Three groups of rats (6 males and 6 females’ rats/group) were fed on control diet, non-Bt corn and Bt corn for 1.5 months and 3 months. After 1.5 months, 3 males and 3 females from each group were sacrificed, and after another 1.5 months, 3 males and 3 females from each group and their offspring were sacrificed. Histopathological examination, blood haematology and serum biochemical analysis were determined. Results indicated significant differences among the tested parameters in the three groups especially Bt group. Severe changes in the liver of Bt group after 3 months were observed.
Reduction of restraint and seclusion through collaborative problem solving: a five-year prospective inpatient study.

OBJECTIVE This study examined usage patterns of restraint and seclusion before and after the implementation of collaborative problem solving (CPS), a manualized therapeutic program for working with aggressive children and adolescents. METHODS The clinical setting was a 15-bed psychiatric inpatient unit for school-age children. A total of 755 children were hospitalized for a total of 998 admissions from fiscal years 2003 to 2007 (median age=11 years; 64% boys). Data were collected for three years before and 1.5 years after the six-month implementation of the CPS model of care. RESULTS There were 559 restraint and 1,671 seclusion events during the study period. After implementation of the CPS model there was a reduction in the use of restraints (from 263 events to seven events per year, representing a 37.6-fold reduction, slope [beta]=-.696) and seclusion (from 432 to 133 events per year, representing a 3.2-fold reduction, beta=-.423). The mean duration of restraints decreased from 41+/-8 to 18+/-20 minutes per episode, yielding cumulative unitwide restraint use that dropped from 16+/-10 to . 3+/-. 5 hours per month (a 45.5-fold reduction, beta=-.674). The mean duration of seclusion decreased from 27+/-5 to 21+/-5 minutes per episode, yielding cumulative unitwide seclusion use that dropped from 15+/-6 to 7+/-6 hours per month (a 2.2-fold reduction; p for trend .01 or better for all slopes). During the early phases of implementation there was a transient increase in staff injuries through patient assaults. CONCLUSIONS CPS is a promising approach to reduce seclusion and restraint use in a child psychiatric inpatient setting. Future research and replication efforts are warranted to test its effectiveness in other restrictive settings.
Patient Related Outcome Measures Dovepress Effect of Combination Treatment on Patient- Related Outcome Measures in Benign Prostatic Hyperplasia: Clinical Utility of Dutasteride and Tamsulosin Overview of Available Treatments Surgical Treatment Medical Treatment Subjective Outcome and Impact on Quali

Background: Benign prostatic hyperplasia, the fourth most commonly diagnosed medical condition in the elderly, is a major underlying cause of lower urinary tract symptoms in men. Medical therapy is usually the first therapeutic option. Combination therapy is increasingly used for better symptom relief and outcome. Methods: We searched the literature using the MEDLINE database for the efficacy of combination therapy in men with benign prostatic hyperplasia in terms of symptom improvement and impact on quality of life. Results: Combination therapy with dutasteride and tamsulosin not only provides better symptom improvement and improved urinary flow rate, but is also associated with a more favorable impact on quality of life and patient satisfaction with treatment than monotherapy. Combination therapy also reduces the risk of events related to disease progression, such as acute urinary retention and benign prostatic hyperplasia-related surgery. Conclusion: Combination therapy with dutasteride and tamsulosin is highly efficacious as medical therapy for benign prostatic hyperplasia in patients with moderate-to-severe lower urinary tract symptoms. Introduction Benign prostatic hyperplasia (BPH), the fourth most commonly diagnosed medical condition in the elderly, affects more than half of men aged older than 50 years and nearly 90% of men over 80 years. 1,2 BPH is one of the major causes of lower urinary tract symptoms in men. These are categorized into three groups of symptoms, ie, voiding symptoms (reduced urinary stream, intermittency, hesitancy, straining, terminal dribble), storage symptoms (frequency, nocturia, urgency, overflow i ncontinence), and post-micturition symptoms (sensation of incomplete bladder emptying, postmicturition dribble). 3 The goal of treatment is mainly focused on improvement in symptom scores, patient-reported quality of life, patient satisfaction, and reduction of risk of disease progression and need for further surgical interventions. 4 Treatment of lower urinary tract symptoms suggestive of BPH is initially planned by assessment of severity of symptoms using quantitative indices, such as the International Prostate Symptom Score (IPSS), which is the most widely accepted American Urological Association (AUA) symptom index. Dovepress Dovepress 72 Djavan et al An important issue in the management of lower urinary tract symptoms is to determine the contribution of bladder outlet obstruction to development of symptoms. However, studies have reported that prostate size and severity of symptoms might not be strongly correlated with the degree of bladder outlet obstruction. Therefore, other pathological conditions of the bladder, prostate, other pelvic organs, and possibly other unknown causes, might contribute to this correlation. 6 Thus, a combination …
Glutamate Uptake Triggers Transporter-Mediated GABA Release from Astrocytes

Background Glutamate (Glu) and γ-aminobutyric acid (GABA) transporters play important roles in regulating neuronal activity. Glu is removed from the extracellular space dominantly by glial transporters. In contrast, GABA is mainly taken up by neurons. However, the glial GABA transporter subtypes share their localization with the Glu transporters and their expression is confined to the same subpopulation of astrocytes, raising the possibility of cooperation between Glu and GABA transport processes. Methodology/Principal Findings Here we used diverse biological models both in vitro and in vivo to explore the interplay between these processes. We found that removal of Glu by astrocytic transporters triggers an elevation in the extracellular level of GABA. This coupling between excitatory and inhibitory signaling was found to be independent of Glu receptor-mediated depolarization, external presence of Ca2+ and glutamate decarboxylase activity. It was abolished in the presence of non-transportable blockers of glial Glu or GABA transporters, suggesting that the concerted action of these transporters underlies the process. Conclusions/Significance Our results suggest that activation of Glu transporters results in GABA release through reversal of glial GABA transporters. This transporter-mediated interplay represents a direct link between inhibitory and excitatory neurotransmission and may function as a negative feedback combating intense excitation in pathological conditions such as epilepsy or ischemia.
UDoNC: An Algorithm for Identifying Essential Proteins Based on Protein Domains and Protein-Protein Interaction Networks

Prediction of essential proteins which are crucial to an organism's survival is important for disease analysis and drug design, as well as the understanding of cellular life. The majority of prediction methods infer the possibility of proteins to be essential by using the network topology. However, these methods are limited to the completeness of available protein-protein interaction (PPI) data and depend on the network accuracy. To overcome these limitations, some computational methods have been proposed. However, seldom of them solve this problem by taking consideration of protein domains. In this work, we first analyze the correlation between the essentiality of proteins and their domain features based on data of 13 species. We find that the proteins containing more protein domain types which rarely occur in other proteins tend to be essential. Accordingly, we propose a new prediction method, named UDoNC, by combining the domain features of proteins with their topological properties in PPI network. In UDoNC, the essentiality of proteins is decided by the number and the frequency of their protein domain types, as well as the essentiality of their adjacent edges measured by edge clustering coefficient. The experimental results on S. cerevisiae data show that UDoNC outperforms other existing methods in terms of area under the curve (AUC). Additionally, UDoNC can also perform well in predicting essential proteins on data of E. coli.
Pathogenic Mutations within the Hydrophobic Domain of the Prion Protein Lead to the Formation of Protease-Sensitive Prion Species with Increased Lethality

ABSTRACT Prion diseases are a group of fatal and incurable neurodegenerative diseases affecting both humans and animals. The principal mechanism of these diseases involves the misfolding the host-encoded cellular prion protein, PrPC, into the disease-associated isoform, PrPSc. Familial forms of human prion disease include those associated with the mutations G114V and A117V, which lie in the hydrophobic domain of PrP. Here we have studied the murine homologues (G113V and A116V) of these mutations using cell-based and animal models of prion infection. Under normal circumstances, the mutant forms of PrPC share similar processing, cellular localization, and physicochemical properties with wild-type mouse PrP (MoPrP). However, upon exposure of susceptible cell lines expressing these mutants to infectious prions, very low levels of protease-resistant aggregated PrPSc are formed. Subsequent mouse bioassay revealed high levels of infectivity present in these cells. Thus, these mutations appear to limit the formation of aggregated PrPSc, giving rise to the accumulation of a relatively soluble, protease sensitive, prion species that is highly neurotoxic. Given that these mutations lie next to the glycine-rich region of PrP that can abrogate prion infection, these findings provide further support for small, protease-sensitive prion species having a significant role in the progression of prion disease and that the hydrophobic domain is an important determinant of PrP conversion. IMPORTANCE Prion diseases are transmissible neurodegenerative diseases associated with an infectious agent called a prion. Prions are comprised of an abnormally folded form of the prion protein (PrP) that is normally resistant to enzymes called proteases. In humans, prion disease can occur in individuals who inherited mutations in the prion protein gene. Here we have studied the effects of two of these mutations and show that they influence the properties of the prions that can be formed. We show that the mutants make highly infectious prions that are more sensitive to protease treatment. This study highlights a certain region of the prion protein as being involved in this effect and demonstrates that prions are not always resistant to protease treatment.
Card, English, and Burr (1978): 25 years later

We revisit the Fitts? law model published 25 years ago by Card, English, and Burr. Their research was important because it was the first comparative evaluation of the mouse, and also the first use of Fitts? law in HCI. For the mouse, they reported MT = 1.03 + 0.096 ID, with throughput reported as the slope reciprocal: TP = 1 / 0.96 = 10.3 bps. We re-analyse their data in view of ISO9241-9, the new standard for evaluating pointing devices. The reanalysis yields a throughput of 2.65 bps, or 4.32 bps including a nominal adjustment for the time for the hand to adjust its grip on the mouse. These values are closer to recently published ISO-conforming values for the mouse.
Evaluation of multiple motion models for multiple pedestrian visual tracking

Multiple targets tracking is a challenging problem due to occlusions or identity switching. Although the use of prior information about the motion of the targets improves the tracking results, a single motion model may not capture the complex dynamic of the targets. This is a common situation with pedestrians, as each person moves in its own way, making tracking a difficult task. In this paper, this problem is faced by using a proposal based on the Interacting Multiple Model (IMM) and implemented in a Bayesian scheme through a particle filter. The core of this approach is to leave the filter choose the motion model that fits better the motion of the targets. The algorithm is evaluated, under several combinations of motion models, with middle-dense crowded scenes from the PETS 2009 dataset.
Fresh frozen plasma and platelet transfusion for nonbleeding patients in the intensive care unit: Benefit or harm?

Objective:Whereas restrictive red cell transfusion has become a standard of care for the critically ill, evidenced-based indications for use of other blood components such as fresh frozen plasma (FFP) and platelet transfusions are limited. We searched the National Library of Medicine PubMed database as well as references of retrieved articles and summarized the current evidence for the use of FFP and platelet transfusions in critically ill patients. Results:Routine coagulation tests are poor determinants of bleeding risk in critically ill patients with coagulopathy. FFP transfusion has limited efficacy and is associated with significant morbidity in critically ill patients, in particular, pulmonary edema and acute lung injury. Routine minimally invasive critical care procedures can be safely performed by experienced clinicians in the setting of mildly abnormal coagulation test results, and there is no evidence that FFP transfusion alters the risk of bleeding. For platelet transfusion, the American Society of Clinical Oncology has developed practice guidelines designed for oncology patients. However, because the pathophysiology of thrombocytopenia in critically ill patients often differs from that of thrombocytopenia in oncology patients, published guidelines for oncology patients may not be applicable. Conclusion:Because the risk-benefit ratio of a liberal FFP or platelet transfusion strategy for critically ill patients may not be favorable, randomized controlled trials are warranted for evaluating a restrictive vs. liberal FFP or platelet transfusion strategy for nonbleeding patients in the intensive care unit.