Miracle-dz/UniFAR-FTUs huggingface dataset:
Road safety and road traffic accidents in Saudi Arabia

Objectives: To identify the changing trends and crucial preventive approaches to road traffic accidents (RTAs) adopted in the Kingdom of Saudi Arabia (KSA) over the last 2.5 decades, and to analyze aspects previously overlooked. Methods: This systematic review was based on evidence of RTAs in KSA. All articles published during the last 25 years on road traffic accident in KSA were analyzed. This study was carried out from December 2013 to May 2014 in the Department of Family and Community Medicine, Taibah University, Al-Madinah Al-Munawwarah, KSA. Results: Road traffic accidents accounted for 83.4% of all trauma admissions in 1984-1989, and no such overall trend was studied thereafter. The most frequently injured body regions as reported in the latest studies were head and neck, followed by upper and lower extremities, which was found to be opposite to that of the studies reported earlier. Hospital data showed an 8% non-significant increase in road accident mortalities in contrast to police records of a 27% significant reduction during the years 2005-2010. Excessive speeding was the most common cause reported in all recent and past studies. Conclusion: Disparity was common in the type of reporting of RTAs, outcome measures, and possible causes over a period of 2.5 decade. All research exclusively looked into the drivers’ faults. A sentinel surveillance of road crashes should be kept in place in the secondary and tertiary care hospitals for all regions of KSA.
Horses for Courses? The Political Discourse of Globalisation and European Integration in the UK and Ireland

In recent years there has been growing interest in the role of discourses of globalisation and European integration in shaping political outcomes. As a variety of authors have suggested, these discourses may play a powerful causal role in determining the trajectory of policy change and, as such, should be treated as objects of enquiry in their own right. Yet, while much recent scholarship has pointed to the need for systematic empirical analysis of policy-making discourses, little such analysis has yet been undertaken. Our aim in this paper is to contribute to this task, by mapping contemporary appeals to globalisation and European integration in two EU states: Britain and the Irish Republic. We present findings from the discourse analysis (using QSR NVivo) of over 100 speeches backed by supplementary interviews in both cases. Building upon, extending and updating an earlier discussion, we develop a theoretical schema for the classification and mapping of a range of different discourses of globalisation and European integration. These we categorise in terms of the contingent or inevitable character attributed to the process in question and the positive, open-ended or negative connotations it is seen to entail. What becomes apparent is the highly strategic ways in which such discourses are used, the articulation of which depends greatly upon the context in which they are deployed and the audience for which they are intended.
Serum fetuin‐A concentration and fetuin‐A‐containing calciprotein particles in patients with chronic inflammatory disease and renal failure

Fetuin‐A (Fet‐A) is an important regulator of extracellular matrix mineralization. Fet‐A plays a critical role in the formation and stabilization of high molecular weight colloidal protein–mineral complexes known as calciprotein particles (CPP). The aim of this study was to examine the effects of inflammation, renal function and dialysis modality on serum Fet‐A and CPP.
Stability Analysis of Takagi–Sugeno Fuzzy Cellular Neural Networks With Time-Varying Delays

This correspondence investigates the global exponential stability problem of Takagi-Sugeno fuzzy cellular neural networks with time-varying delays (TSFDCNNs). Based on the Lyapunov-Krasovskii functional theory and linear matrix inequality technique, a less conservative delay-dependent stability criterion is derived to guarantee the exponential stability of TSFDCNNs. By constructing a Lyapunov-Krasovskii functional, the supplementary requirement that the time derivative of time-varying delays must be smaller than one is released in the proposed delay-dependent stability criterion. Two illustrative examples are provided to verify the effectiveness of the proposed results
N = 4 gauged supergravity and a IIB orientifold with fluxes

We analyse the properties of a spontaneously broken D = 4, N = 4 supergravity without cosmological constant, obtained by gauging translational isometries of its classical scalar manifold. This theory offers a suitable low energy description of the super-Higgs phases of certain type-IIB orientifold compactifications with 3-form fluxes turned on. We study its N = 3, 2, 1, 0 phases and their classical moduli spaces and we show that this theory is an example of no-scale extended supergravity.
Interferon‐lambda4 genetic polymorphism is associated with the therapy response for hepatitis C virus recurrence after a living donor liver transplant

The standard therapy against hepatitis C virus (HCV) recurrence postliver transplantation includes interferon (IFN)α and ribavirin. IFNL4 ss469415590 polymorphism has been reported as a novel predictor of the response to IFN therapy for chronic HCV infection. We examined the impact of IFNL4 polymorphism on the responsiveness to IFN therapy after liver transplantation. Tissue specimens were collected from 80 HCV‐infected recipients and 78 liver donors, and their IFNL4 ss469415590 genotype, hepatic IFNL4 and interferon‐stimulated genes' mRNA expression levels were examined. The association of the polymorphism and expression levels in terms of the IFN therapy response to HCV recurrence was analysed. Most individuals who had rs8099917 risk alleles also had ss469415590 risk alleles (R2 = 0.9). Sustained virological response (SVR) rates were higher in both liver graft recipients and transplants with ss469415590 TT/TT alleles than in those with the risk ΔG allele (P = 0.003 and P = 0.005, respectively). In recipients with ss469415590 TT/TT, IFNL4 TT mRNA levels showed no significant differences between livers of patients who responded to therapy and those who did not (P = 0.4). In recipients with the risk ΔG allele, IFNL4 ΔG mRNA expression levels were significantly lower in SVR patients than in non‐SVR patients (P = 0.02). Hepatic interferon stimulable genes and IFNL4 mRNA expression were correlated. Our findings suggest that analysing the ss469415590 genotype and IFNL4 ΔG expression provides a novel prediction strategy for the possible response to IFN therapy after liver transplantation.
Health-related quality of life/patient-reported outcomes in relapsed ovarian cancer: Results from a randomized phase III study of trabectedin with pegylated liposomal doxorubicin (PLD) versus PLD alone.

5526 Background: In an open-label, multicenter, randomized phase III study comparing the combination of trabectedin and PLD to PLD alone in patients with relapsed ovarian cancer, the combination demonstrated significantly improved progression free survival and response rates, manageable non-cumulative toxicity, and fewer PLD-associated adverse events. We studied the impact of the combination of trabectedin with PLD on the quality of life (QoL)/patient-reported outcomes (PRO) evaluated as part of the trial. METHODS QoL/PRO questionnaires, EORTC-QLQ C30, OV28, and EQ-5D were completed by patients at screening and on Day 1 of every other treatment cycle starting with Cycle 1, and at the end-of-treatment visit. Global health status/QoL, fatigue, rain subscales from QLQ C30, and abdominal pain/GI symptoms scale from OV28 were chosen a priori for primary analyses. Other scales of the three questionnaires were analyzed on a supportive basis. RESULTS A total of 672 patients were randomized. 663 (98%) completed at least the baseline questionnaires. Median cycles of treatment was 6 (131 days) for the combination arm and 5 (143 days) for the monotherapy arm. Mixed effects models (using a covariance structure of AR[1]) predicting the score at baseline and follow-up scores as a function of treatment, days after baseline, and interaction between treatment and days after baseline showed no significant differences between the treatment arms for any of the prespecified scales. Similar analyses of other scales, including EQ-5D Health Index scores and Health State on the Visual Analog Scale, support the findings. CONCLUSIONS The addition of trabectedin to PLD results in superior efficacy in patients with relapsed ovarian cancer, with no added decrement to overall health status as assessed by PRO. [Table: see text].
A polar‐localized iron‐binding protein determines the polar targeting of Burkholderia BimA autotransporter and actin tail formation

Intracellular bacterial pathogens including Shigella, Listeria, Mycobacteria, Rickettsia and Burkholderia spp. deploy a specialized surface protein onto one pole of the bacteria to induce filamentous actin tail formation for directional movement within host cytosol. The mechanism underlying polar targeting of the actin tail proteins is unknown. Here we perform a transposon screen in Burkholderia thailandensis and identify a conserved bimC that is required for actin tail formation mediated by BimA from B. thailandensis and its closely related pathogenic species B. pseudomallei and B. mallei. bimC is located upstream of bimA in the same operon. Loss of bimC results in even distribution of BimA on the outer membrane surface, where actin polymerization still occurs. BimC is targeted to the same bacterial pole independently of BimA. BimC confers polar targeting of BimA prior to BimA translocation across bacterial inner membrane. BimC is an iron‐binding protein, requiring a four‐cysteine cluster at the carboxyl terminus. Mutation of the cysteine cluster disrupts BimC polar localization. Truncation analyses identify the transmembrane domain in BimA being responsible for its polar targeting. Consistently, BimC can interact with BimA transmembrane domain in an iron binding‐dependent manner. Our study uncovers a new mechanism that determines the polar distribution of bacteria‐induced actin tail in infected host cells.
A Comparison of Systematic Screening Tools for Emotional and Behavioral Disorders

Early identification of students who might develop emotional and behavioral disorders (EBD) is essential in preventing negative outcomes. Systematic screening tools are available for identifying elementary-age students with EBD, including the Systematic Screening for Behavior Disorders (SSBD) and the Student Risk Screening Scale (SRSS). The SSBD is considered the gold standard for systematic EBD screening. The brevity of the SRSS is often favored with respect to resource allocation. The authors evaluated the concurrent validity of the SRSS to predict SSBD results when used to detect school children with externalizing or internalizing behavior concerns. Between low- and high-risk categories, the SRSS had excellent accuracy for predicting both externalizing (95%) and internalizing (93%) problems on the SSBD. Sensitivity (94%) and specificity (95%) were both excellent for externalizing behavior, but for internalizing behavior, sensitivity was lower (44%), while specificity was excellent (95%). Receiver-operating characteristic analysis also suggested that the SRSS was more accurate for detecting externalizing than internalizing behaviors. Limitations and future directions are offered.
The Reciprocal Relationship between Research and Development: An Example Involving a Decoding Strand for Poor Readers

The two major goals of this paper are to describe a 5-year research and development project that led to the creation of a decoding program for poor readers in Grades 1–8 and to report the results of our research along the way. Unlike most research and development projects, research did not simply follow program development and assess its effectiveness. Instead, action research was used as a means of developing the program and program development led to modifications in the research as well. Thus, research and development had a reciprocal relationship and evolved together. The word identification program that eventually took shape emphasized phonemic awareness and decoding by analogy. Our findings were consistent with the conclusion that the word identification program enabled students to become better decoders and allowed them to make small gains in spelling, vocabulary, and comprehension.
Secure object identification: or: solving the Chess Grandmaster Problem

Many applications of cryptographic identification protocols are vulnerable against physical adversaries who perform real time attacks. For instance, when identifying a physical object like an automated teller machine, common identification schemes can be bypassed by faithfully relaying all messages between the communicating participants. This attack is known as mafia fraud.The Probabilistic Channel Hopping (PCH) system we introduce in this paper, solves this problem by hiding the conversation channel between the participants. The security of our approach is based on the assumption that an adversary cannot efficiently relay all possible communication channels of the PCH system in parallel.
Cigarette smoking is associated with an increased risk of biochemical disease recurrence, metastasis, castration‐resistant prostate cancer, and mortality after radical prostatectomy

The current study was conducted to analyze the association between cigarette smoking and metastasis (the primary outcome) as well as time to biochemical disease recurrence (BCR), metastasis, castration‐resistant prostate cancer (CRPC), and prostate cancer‐specific and overall mortality (secondary outcomes) after radical prostatectomy among men from the Shared Equal Access Regional Cancer Hospital cohort.
Previous Renal Replacement Therapy Time at Start of Peritoneal Dialysis Independently Impact on Peritoneal Membrane Ultrafiltration Failure

Background. Peritoneal membrane changes are induced by uraemia per se. We hypothesise that previous renal replacement therapy (RRT) time and residual renal function (RRF) at start of peritoneal dialysis impact on ultrafiltration failure (UFF). Methods. The time course of PET parameters from 123 incident patients, followed for median 26 (4–105) months, was evaluated by mixed linear model. Glucose 3.86% solutions were not used in their standard therapy. Sex, age, diabetes, previous RRT time, RRF, comorbidity score, PD modality and peritonitis episodes were investigated as possible determinants of UFF-free survival. Results. PET parameters remained stable during follow up. CA125 decreased significantly. Inherent UFF was diagnosed in 8 patients, 5 spontaneously recovering. Acquired UFF group presented type I UFF profile with compromised sodium sieving. At baseline they had lower RRF and longer previous time of RRT which remained significantly associated with UFF-free survival by Cox multivariate analysis (HR 0.648 (0.428–0.980), P = 0.04) and (HR 1.016 (1.004–1.028), P = 0.009, resp. ). UFF free survival was 97%, 87% and 83% at 1, 3 and 5 years, respectively. Conclusions. Inherent UFF is often unpredictable but transitory. On the other hand baseline lower RRF and previous RRT time independently impact on ultrafiltration failure free survival. In spite of these detrimental factors generally stable long-term peritoneal transport parameters is achievable with a 5-year cumulative UFF free survival of 83%. This study adds a further argument for a PD-first policy.
Multipath Parameter Estimation from OFDM Signals in Mobile Channels

We study multipath parameter estimation from orthogonal frequency division multiplex signals transmitted over doubly dispersive mobile radio channels. We are interested in cases where the transmission is long enough to suffer time selectivity, but short enough such that the time variation can be accurately modeled as depending only on per-tap linear phase variations due to Doppler effects. We therefore concentrate on the estimation of the complex gain, delay and Doppler offset of each tap of the multipath channel impulse response. We show that the frequency domain channel coefficients for an entire packet can be expressed as the superimposition of two-dimensional complex sinusoids. The maximum likelihood estimate requires solution of a multidimensional non-linear least squares problem, which is computationally infeasible in practice. We therefore propose a low complexity suboptimal solution based on iterative successive and parallel cancellation. First, initial delay/Doppler estimates are obtained via successive cancellation. These estimates are then refined using an iterative parallel cancellation procedure. We demonstrate via Monte Carlo simulations that the root mean squared error statistics of our estimator are very close to the Cramer-Rao lower bound of a single two-dimensional sinusoid in Gaussian noise.
Luminal 5‐HT stimulates colonic bicarbonate secretion in rats

The bioactive monoamine 5‐HT, implicated in the pathogenesis of functional gastrointestinal disorders, is abundantly synthesized and stored in rat proximal colonic mucosa and released to the gut lumen and subepithelial space. Despite much data regarding its expression and function, the effects of luminal 5‐HT on colonic anion secretion have not been fully investigated.
Detection of mRNA by reverse-transcription PCR as an indicator of viability in Phytophthora ramorum

Summary In the last few decades, the use of molecular tools has greatly improved the efficiency of plant disease diagnosis. However, one of the major setbacks of most molecular diagnostic approaches is their inability to differentiate between dead and viable pathogens. We propose a new strategy for the detection of plant pathogens, based on the use of mRNA as a viability marker, on the basis that mRNA degradation in dead cells is significantly more rapid than that of DNA. A real-time reverse-transcription PCR (RT-PCR) assay targeting the mRNA of the subunit I of the cytochrome oxidase gene was designed for Phytophthora ramorum, the causal agent of sudden oak death and ramorum blight. In controlled laboratory tests, the developed RT-PCR assay did not detect the target mRNA a week after the pathogen had been killed by rapid lyophilization, while DNA of the pathogen could still be detected 3 months after the pathogen had died. The RT-PCR assay was then compared with a traditional culturing approach using PARP selective medium and two nested real-time PCR techniques on symptomatic California bay laurel leaves. Samples were either collected in three different sites in July, or in the same site but in three different seasons. Overall, RT-PCR results showed less positive samples than DNA-based nested PCR techniques (p < 0.0001), but more than culturing (p = 0.017). Nested PCR-positive but RT-PCR-negative samples may not be viable. On the other hand, RT-PCR-positive but culture-negative samples may be viable but dormant. A comparative analysis of the results indicated that RT-PCR and culturing provide comparable results when climatic conditions are optimal for the pathogen, but RT-PCR may be the most accurate approach to determine pathogen viability when climatic conditions are less than optimal for the pathogen.
Liver function in alpha-1-antitrypsin deficient individuals at 37 to 40 years of age

Abstract Severe alpha-1-antitrypsin (AAT) deficiency (PiZZ) is a risk factor for liver disease, but the prevalence of liver cirrhosis and hepatocellular cancer in PiZZ adults is unknown. The risk of liver disease in adults with moderate AAT deficiency (PiSZ) is also unknown. A cohort of 127 PiZZ, 2 PiZnull, 54 PiSZ, and 1 PiSnull individuals were identified by the Swedish national neonatal AAT screening program between 1972 and 1974, when all 200,000 newborn infants in Sweden were screened for AAT deficiency. The cohort has been followed up since birth. Our aim was to study liver function and signs of liver disease in this cohort at 37 to 40 years of age in comparison with a matched, random sample of control subjects identified from the population registry. Eighty seven PiZZ, 32 PiSZ, and 92 control subjects (PiMM) answered a questionnaire on medication and alcohol consumption and provided blood samples. Liver stiffness was assessed by Acoustic Radiation Force Impulse (ARFI) elastography in 32 PiZZ, 15 PiSZ, and 51 PiMM subjects. The median of liver function tests and procollagen-III-peptide were within the normal range in all Pi subgroups. However, the PiZZ men had significantly higher plasma bilirubin than the PiMM men (P = 0.018). Plasma [Latin Small Letter Gamma]-glutamyl transferase (GGT) was significantly higher in the PiZZ men (P = 0.009) and the PiSZ men (P = 0.021) compared with the PiMM men. The median of liver stiffness was significantly higher in the PiZZ men (P = 0.037) and the PiSZ men (P = 0.032) compared with the PiMM men. The PiZZ women taking medication influencing liver enzymes had significantly higher GGT than the PiMM women on the corresponding treatment (P = 0.023). These AAT-deficient individuals identified by neonatal screening have normal plasma levels of liver function tests, and no clinical signs indicating liver disease at the age of 37 to 40 years. However, bilirubin, GGT, and liver stiffness are significantly higher in PiZZ men than PiMM men.
Erwinia carotovora Subspecies Produce Duplicate Variants of ExpR, LuxR Homologs That Activate rsmA Transcription but Differ in Their Interactions with N-Acylhomoserine Lactone Signals

ABSTRACT The N-acylhomoserine lactone (AHL) signaling system comprises a producing system that includes acylhomoserine synthase (AhlI, a LuxI homolog) and a receptor, generally a LuxR homolog. AHL controls exoprotein production in Erwinia carotovora and consequently the virulence for plants. In previous studies we showed that ExpR, a LuxR homolog, is an AHL receptor and that it activates transcription of rsmA, the gene encoding an RNA binding protein which is a global negative regulator of exoproteins and secondary metabolites. An unusual finding was that the transcriptional activity of ExpR was neutralized by AHL. We subsequently determined that the genomes of most strains of E. carotovora subspecies tested possess two copies of the expR gene: expR1, which was previously studied, and expR2, which was the focus of this study. Comparative analysis of the two ExpR variants of E. carotovora subsp. carotovora showed that while both variants activated rsmA transcription, there were significant differences in the patterns of their AHL interactions, the rsmA sequences to which they bound, and their relative efficiencies of activation of rsmA transcription. An ExpR2− mutant produced high levels of exoproteins and reduced levels of RsmA in the absence of AHL. This contrasts with the almost complete inhibition of exoprotein production and the high levels of RsmA production in an AhlI− mutant that was ExpR1−. Our results suggest that ExpR2 activity is responsible for regulating exoprotein production primarily by modulating the levels of an RNA binding protein.
Organizational social capital Scale based on Nahapiet and Ghosal model: development and validation

The goal of this work is to develop and validate a scale to identify workers' behaviors as well as those of organizations, and to understand how they develop and build enterprise competitiveness through organizational social capital, a complex network of relationship that is critical to business success. For this the present theories were mapped out to identify the similarities and differences within social capital, focusing on organizational social capital. With this background a Nahapiet and Ghosal three dimensional model was chosen as the most suitable construct with which to create the instrument. All methodological research steps for behavioral instrument creation were taken into account. The questionnaire created was refined and validated for semantic and content validity, then it was tested using statistical tools for items reduction through Exploratory Factor Analysis to refine the instrument. The scale was approved in the tests and the findings of this process also led to the conclusion that social capital is a one-dimensional construct.