Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Ossicle Resection in the Lateral Ligament Repair for Treatment of Chronic Lateral Ankle Instability

Background: The management of an ossicle or avulsion fragment of the fibular tip in chronic lateral ankle instability is an open question. Some authors maintain the necessity of osteosynthesis for reconstruction of the lateral ligamentous structure if the fragment is large. We hypothesized that the modified Broström procedure with resection of the ossicle would result in good outcomes compared to that of the same procedure for chronic lateral instability patients without ossicle. Methods: Between December 2004 and December 2010, 102 patients underwent the modified Broström procedure for chronic lateral instability. Of these, 82 patients (86 ankles) were available for this study. Forty ankles had ossicles at the fibular tip (group O), 46 had no ossicle (group N). The average follow-up period was 33 months in group O and 37 months in group N. Irrespective of size, if there were ossicles we resected all fragments and performed the modified Broström procedure. To analyze the surgical outcome, American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot pain and function scales and Karlsson scores were compared between the 2 groups preoperatively and postoperatively. Results: Preoperative scores in the 2 groups showed no significant difference, except for AOFAS pain score. There was no significant difference in postoperative AOFAS pain and function score between the groups. Postoperative Karlsson score was significantly higher in group O than in group N (P = .001). Group O was divided into 2 subgroups by the largest diameter of the ossicle (< 10 mm and ≥ 10 mm); there was no significant difference in surgical outcomes. Conclusions: In the treatment of chronic lateral instability of ankle, if there are ossicles on the fibular tip, osteosynthesis of the ossicles may not be necessary, even if the size is considerable. Modified Broström procedure after resection of the ossicle was successful. Level of Evidence: Level III, retrospective case series.
Detection of regional myocardial perfusion deficit using rest and stress perfusion MRI: a feasibility study.

OBJECTIVE Providing high temporal and spatial resolution, perfusion MRI is an attractive alternative to traditional radionuclide methods like SPECT and PET. Although first-pass perfusion MRI examinations have gained increasing attention during the past years, this technique still exhibits relatively low signal-to-noise ratio and cardiac coverage. Previous studies have suggested that refocused gradient sequence technology (e.g., true fast imaging with steady-state precession [FISP]) should improve perfusion MRI examinations. The aim of this study was to assess myocardial perfusion deficits in patients with proven coronary artery disease using a saturation recovery true FISP perfusion sequence. SUBJECTS AND METHODS Rest and stress perfusion MRI studies were performed in 22 patients with coronary artery disease at 1.5 T using a multislice saturation recovery true FISP sequence after the bolus injection of 0.025 mmol/kg of body weight of gadopentetate dimeglumine. The myocardium of each slice was divided into 12 radial segments with subdivision into subendocardial and subepicardial subregions. Myocardial perfusion was assessed semiquantitatively and independently for each subregion. The standard of reference for myocardial perfusion was SPECT. Delayed enhancement images were acquired after the injection of 0.15 mmol/kg of body weight of gadopentetate dimeglumine. RESULTS Sensitivity and specificity of perfusion MRI examinations for the detection of perfusion deficits were 81% and 89%, respectively, for the semiquantitative perfusion parameter upslope and 78% and 86% for the parameter peak signal intensity. More specifically, rest perfusion examinations were able to detect areas of infarction, whereas stress examinations increased the perfusion differences between normal and ischemic myocardial areas. Excellent correlation was observed between rest perfusion and late enhancement findings (r = 0.90). CONCLUSION In patients with single-vessel coronary artery disease, perfusion deficits can reliably be detected using a saturation recovery true FISP sequence. Semiquantitative perfusion parameters upslope and peak signal intensity yielded similar results.
Artificial Intelligence In

It goes without saying that coronavirus (COVID-19) is an infectious disease and many countries are coping with its different variants. Owing to the limited medical facilities, vaccine and medical experts, need of the hour is to intelligently tackle its spread by making artificial intelligence (AI) based smart decisions for COVID-19 suspects who develop different symptoms and they are kept under observation and monitored to see the severity of the symptoms. The target of this study is to analyze COVID-19 suspects data and detect whether a suspect is a COVID-19 patient or not, and if yes, then to what extent, so that a suitable decision can be made. The decision can be categorized such that an infected person can be isolated or quarantined at home or at a facilitation center or the person can be sent to the hospital for the treatment. This target is achieved by designing a mathematical model of COVID-19 suspects in the form of a multi-criteria decision making (MCDM) model and a novel AI based technique is devised and implemented with the help of newly developed plithogenic distance and similarity measures in fuzzy environment. All findings are depicted graphically for a clear understanding and to provide an insight of the necessity and effectiveness of the proposed method. The concept and results of the proposed technique make it suitable for implementation in machine learning, deep learning, pattern recognition etc.
Glutathione S-Transferase M1, T1 and P1 Polymorphisms and Bladder Cancer Risk in Egyptians

Previous studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27–5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63, 95%CI 0.85–3.10). 18.1% of cases but only 7.3% of controls were GSTP1*B*B homozygotes (OR 2.38, 95%CI 0.83–6.87). The presence of two or more a priori at-risk genotypes was associated with increased bladder cancer risk (OR 2.42; 95%CI 1.47–3.97). These results suggest that polymorphisms in the GST genes are associated with increased risk of bladder cancer among Egyptians.
Beery-Buktenica Developmental Test of Visual-Motor Integration (Beery-VMI): lessons from exploration of cultural variations in visual-motor integration performance of preschoolers.

BACKGROUND Visual-motor integration (VMI) is important in children's development because it is associated with the performance of many functional skills. Deficits in VMI have been linked to difficulties in academic performance and functional tasks. Clinical assessment experience of occupational therapists in Singapore suggested that there is a potential difference between the VMI performance of Singaporean and American children. Cross-cultural studies also implied that culture has an influence on a child's VMI performance, as it shapes the activities that a child participates in. The purpose of this study was to (1) explore if there was a difference between the VMI performance of Singaporean and American preschoolers, and (2) determine if there were ethnic differences in the VMI performance of Singaporean preschoolers. METHODS The Beery-VMI, which was standardized in America, is commonly used by occupational therapists in Singapore to assess the VMI ability of children. We administered the Beery-VMI (fifth edition) full form test (excluding the supplemental tests) to 385 preschoolers (mean age = 63.3 months) from randomly selected schools in Singapore. We compared the scores of Singaporean preschoolers with those of the American standardization norms using the one-sample t-test. Scores of different ethnic groups among the Singapore population were also compared using a one-way anova, followed by the Bonferroni post-hoc test. RESULTS Singaporean preschoolers and the standardization sample of American children performed significantly differently in all age groups (P < 0.05). Among the Singapore population, the scores were also significantly different (P < 0.05) between the (i) Chinese and Malay and (ii) Chinese and Indians ethnic groups. CONCLUSION Preschoolers from different cultural and ethnic groups had different VMI performance. Certain cultural beliefs and practices may affect VMI performance. Clinicians should exercise caution when using an assessment in communities and cultures outside the ones on which it was standardized.
Channel acquisition and tracking for MC-CDMA uplink transmissions

This paper deals with channel acquisition and tracking in the uplink of a multicarrier code division multiple access (MC-CDMA) system. The transmission medium is characterized by multipath propagation, and the goal is to estimate the channel frequency response and the noise-power of each active user. Channel acquisition is performed jointly with the noise-power estimation following two different approaches. The first assumes independently faded subcarriers, while the second exploits the fading correlation across the signal bandwidth to improve the system performance. Both schemes are based on the maximum likelihood (ML) criterion and exploit some training blocks carrying known symbols. Channel tracking is pursued through least mean square (LMS) techniques using data decisions provided by a partial parallel interference cancellation (PPIC) receiver. Numerical results are given to highlight the effectiveness of the proposed methods and to present comparisons with other existing solutions
Functional Expression of Chitinase and Chitosanase, and Their Effects on Morphologies in the Yeast Schizosaccharomyces pombe

The chitinase A (chiA) gene from Enterobacter sp. G-1 and the chitosanase A (choA) gene from Matsuebacter chitosanotabidus 3001 were expressed separately and simultaneously in the yeast Schizosaccharomyces pombe. The chiA gene was placed under the transcriptional control of the nmt1 promoter with the glutathione S transferase (GST), and the choA gene was expressed by the human cytomegalovirus (hCMV) promoter with the P factor secretion signal (P3). The expressed proteins of ChoA and GST-ChiA were enzymatical active and were detected as 34-kDa and 80-kDa, respectively, by Western blot analysis. The transformant that expressed the choA gene was able to secrete ChoA efficiently into the culture medium with the specific activity of 102.36 U/mg protein. When the chiA gene was expressed in S. pombe, yeast cells grew slowly and cells became elongated, but when the choA gene was expressed, cells became swollen. Expression of both the chiA and the choA genes resulted in elongated and fat cells.
A communication architecture for high-speed networking

The horizontally oriented protocol structure (HOPS) is proposed. The horizontal structure, coupled with a small number of layers, eliminates unnecessary replication and processing of functions and lowers the unnecessary interprocess communication burden of the protocol execution-for example, unnecessary error detection for voice packets in integrated applications and unnecessary error detection in multiple layers for data applications are eliminated, the overhead associated with multi-peer-to-peer connection to multilayer architecture is substantially reduced, etc. The proposed architecture lends itself more naturally to full parallel implementation. Parallelism offers the potential of increased protocol processing rates, reduction in processing latency, and further reduction in processing overhead; and with the advances in VLSI, full parallel implementation becomes more and more feasible. The scheme also features selective functionality, which permits the protocol to easily adjust itself to the kind of performance demanded by the network-application requirements. <<ETX>>
Change in common carotid artery diameter, distensibility and compliance in subjects with a recent history of impaired glucose tolerance: a 3‐year follow‐up study

Objective To assess the development of common carotid artery properties (diameter, distensibility and compliance) in a cohort of 140 subjects (mean age 65.8 years, SD 7.5 years) originally diagnosed as impaired glucose tolerant in a population-based study, and to explore determinants of changes observed. Design An observational, longitudinal study over a 3-year-period. Methods Vessel wall movement detector system based on ultrasonography, linear generalized estimating equations. Results Carotid artery diameter rose from 6.87–7.02 mm (+ 2.2%, P < 0.001). Distensibility decreased from 11.8 to 10.9 × 10−3 kPa−1 (−8.3%, P = 0.009). Compliance decreased from 0.44–0.43 mm2 kPa−1 (P = 0.17). Changes in blood pressure level were negatively associated with changes in distensibility and compliance. Baseline fasting glucose levels were positively associated with changes in diameter, while fasting insulin levels were negatively associated with changes in distensibility and compliance in men, but not in women. Conclusions In subjects with a recent history of impaired glucose tolerance, we observed an increase in carotid artery diameter and a decrease in distensibility. Change in blood pressure level and baseline fasting glucose and HbA1c levels were positively related to the increase in diameter. In men, but not in women, baseline fasting insulin levels were associated with an acceleration of these changes.
Ontology Learning for the Semantic Web

The Semantic Web relies heavily on formal ontologies to structure data for comprehensive and transportable machine understanding. Thus, the proliferation of ontologies factors largely in the Semantic Web's success. The authors present an ontology learning framework that extends typical ontology engineering environments by using semiautomatic ontology construction tools. The framework encompasses ontology import, extraction, pruning, refinement and evaluation.
The face of rejection: Rejection sensitivity moderates dorsal anterior cingulate activity to disapproving facial expressions

Abstract Previous research has examined neural responses to threatening facial expressions such as those displaying anger, fear, and disgust. Here, we examined neural responses to a different type of threatening facial expression that primarily signifies a threat to social connection, namely a “disapproving” facial expression. We hypothesized that neural responses to disapproving facial expressions would be moderated by individual differences in rejection sensitivity. Using functional magnetic resonance imaging (fMRI), we scanned participants while they viewed brief video clips of facial expressions depicting disapproval, anger, and disgust. As expected, all three expressions yielded bilateral amygdala activation relative to a resting baseline. Additionally, individuals who scored higher on a measure of rejection sensitivity exhibited greater dorsal anterior cingulate cortex activity in response to disapproving facial expressions, but not in response to anger or disgust facial expressions. Results suggest that, at the neural level, individuals high in rejection sensitivity may be more sensitive to facial expressions signaling potential rejection, but not to threatening facial expressions in general. Results also suggest that disapproving facial expressions convey a distinct type of threat and should be considered in future studies of socially threatening facial expressions.
Mechanical properties of polyvinylchloride-coated fabrics processed with Precontraint® technology

This article presents the mechanical properties of polyvinylchloride-coated fabrics with Precontraint® technology. First, groups of off-axial tests are carried out, and the corresponding strength criteria are discussed. Then, the biaxial tests are carried out on the material without initial loading and the material after cyclic loading, and the corresponding stress–strain surfaces are studied. Finally, the effects of temperature on the mechanical properties are studied. Results show that this material is typically orthotropic and its strength can be predicted by the Tsai–Hill strength criterion. The differences between the mechanical properties of the warp and the weft are not significant, because the Precontraint® technology used in the processing reduces significantly the discrepancies, compared with common plain woven fabrics. The material without initial loading is nonlinear and viscoelastic, and after cyclic loading it becomes linear and its stiffness increases. The biaxial tensile behaviors are affected by biaxial loading significantly, and then different constitutive relations should be conducted regarding to different service conditions. With temperature increasing, the tensile strength and the elastic modulus gradually decreases, and the breaking strain increases.
Synthesis and Formulation of Zinc-strengthened Calcium Phosphate Polycarboxylate Cements

A novel zinc-strengthened calcium phosphate polycarboxylate cement modified with amino acid has been developed. Synthesis of glass fillers and monomers as well as polymers and formulation of the cements are described. The effects of silanization, sintering, glass composition, grafting ratio of the methacrylate groups, molecular weight, tartaric acid and polymer content on compressive strength and curing time were investigated. The results show that both silanization and sintering of glass improved compressive strength and extended curing time. An appropriate ratio balance between zinc oxide and hydroxyapatite and between polymer, comonomer and water gave the best mechanical performance. With increasing grafting ratio and molecular weight compressive strength increased. With increasing polymer content and tartaric acid the curing time increased. The curing time decreased with increasing grafting ratio and molecular weight. It is concluded that this experimental cement has shown great potential as a bioactive cement for dental and orthopedic applications, based on its inherent compositions and mechanical strengths.
Ischemia-Reperfusion The protective effect of methylene blue in lungs , small bowel and kidney after intestinal ischemia and reperfusion 1 A influência do azul de metileno na prevenção da lesão pulmonar , intestinal e renal após isquemia-reperfusão intestinal

Purpose: To study the role of methylene blue as an inhibitor of superoxide production by xanthine oxidase. Methods: Thirty-two Wistar rats were divided into 2 groups of 16 animals: the control group and the experimental group. All were submitted to a laparotomy for the occlusion of the cranial mesenteric artery during 60 minutes. The reperfusion was confirmed by the pulsation of the artery after the release of the temporary ligature and color change of the intestines. In the animals of the control group, 2 ml of saline were injected in the peritoneal cavity and in the animals of the experimental group, 2 ml of methylene blue were injected in the peritoneal cavity. After reperfusion for 4 hours, the animals were then sacrificed. The lungs were excised from all 32 rats. Simultaneously, the small intestine and kidneys were ressected in 20 animals (10 from the control group and 10 from the experimental group). Samples of the organs were taken to evaluate the action of xanthine-oxidase, for histopathology studies and for characterization of the edema. Results: In the animals of the experimental group, the inflammatory lesion as well as the edema in the lung was greater than in the control group. The intestinal and renal lesions were similar in both groups, but the lung damage was superior to that observed in the intestines and kidneys. Conclusion: Despite similar action of the xanthine oxidase in the control and the experimental group, after intestinal ischemia and reperfusion, the protective effect of methylene blue was observed only in the lungs of the experimental group.
Characterizing bone material composition and structure in the ovariectomized ( OVX ) rat model of osteoporosis .

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Dissimilar Fitness Associated with Resistance to Fluoroquinolones Influences Clonal Dynamics of Various Multiresistant Bacteria

Fitness cost associated with resistance to fluoroquinolones was recently shown to vary across clones of methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase-producing Klebsiella pneumoniae. The resulting dissimilar fitness should have influenced the clonal dynamics and thereby the rates of resistance for these pathogens. Moreover, a similar mechanism was recently proposed for the emergence of the H30 and H30R lineages of ESBL-producing E. coli and the major international clone (ribotype 027) of Clostridium difficile. Furthermore, several additional international clones of various multiresistant bacteria are suspect to have been selected by an analogous process. An ability to develop favorable mutations in the gyrase and topoisomerase IV genes seems to be a prerequisite for pathogens to retain fitness while showing high-level resistance to fluoroquinolones. Since, the consumption of other “non-fluoroquinolone” groups of antibiotics have also contributed to the rise in resistance rates a more judicious use of antibiotics in general and of fluoroquinolones in particular could ameliorate the international resistance situation.