Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of interstitial cystitis symptoms in a managed care population.

PURPOSE We calculated the prevalence of symptoms typically associated with interstitial cystitis (IC) in men and women in a managed care population in the Pacific Northwest. MATERIALS AND METHODS International Classification of Diseases-9 based queries of the Kaiser Permanente Northwest, Portland, Oregon database were used to identify subjects with IC exclusion criteria, who were excluded from further analysis. A total of 10,000 questionnaires, including 5,000 for women and 5,000 for men, were mailed to subjects with codes indicating bladder symptoms and to those with none of the codes. The questionnaires included questions about the presence of IC symptoms and the O'Leary-Sant interstitial cystitis questionnaire. IC symptoms were defined in 2 ways, that is as 1) pelvic pain at least 3 months in duration plus urgency or frequency at least 3 months in duration and 2) the same criteria plus pain increasing as the bladder fills and/or pain relieved by urination. RESULTS The prevalence of IC symptoms according to definitions 1 and 2 was 11.2% and 6.2% in women, and 4.6% and 2.3% in men, respectively. Symptoms were long-standing (duration greater than 1 year in 80% of cases) and bothersome (severity score 5 or greater in greater than 50%). Mean O'Leary-Sant interstitial cystitis questionnaire scores were 15.94 in subjects with definition 1 IC symptoms, 18.97 in those with definition 2 IC symptoms and 6.69 in those with no IC symptoms (p <0.001). Symptoms were most common and most severe in subjects previously diagnosed with IC. CONCLUSIONS The prevalence of IC symptoms is 30 to 50-fold higher in women and 60 to 100-fold higher in men than the prevalence of a coded physician diagnosis of IC in the same population. Although these findings are not conclusive, they imply that IC may be significantly under diagnosed.
Attachment Styles, Self-Esteem, and Patterns of Seeking Feedback from Romantic Partners

Previous research indicates that persons with secure or dismissing attachment styles differ dramatically in their tolerance of and appreciation for intimacy; despite these differences, both types of individuals display high self-esteem. The two groups' interpersonal orientations suggest that their sources of self-esteem may differ. Secure individuals should derive self-esteem from warm associations with others, whereas dismissing individuals, lacking such associations, may learn to compensate by deriving self-esteem from alternative sources. To test these ideas, the authors related attachment styles to two distinct components of self-esteem-self-liking and self-competence. Overall, security was associated with self-liking, whereas dismissing avoidance was associated with self-competence. The former results were qualified somewhat by gender: Although females' security was associated solely with self-liking, males' security was associated with both self-liking and self-competence. Discussion focuses on the role of relationships in the maintenance of self-worth.
Race and Gender: An Analysis of the Sources and Reporters in Local Television Coverage of the 2002 Michigan Gubernatorial Campaign

This study examined how race and gender of reporters and community diversity influenced use of women and minority sources in local television coverage of the 2002 governor's race in Michigan. Content analysis of campaign stories broadcasted by four local television stations revealed that women reporters were more likely than their male colleagues to use women and nonpartisan sources such as experts and ordinary citizens. But minority journalists were only slightly more likely to use minority sources and were less likely than nonminorities to use nonpartisan sources.
How Children with Autism and Asperger Syndrome Respond to Questions: a ‘Naturalistic’ Theory of Mind Task

In light of a well-documented deficit in theory of mind found in high-functioning individuals with autism (HFA) and Asperger Syndrome (AS), this article explores HFA and AS children’s social-cognitive understanding of other people as reflected in their linguistic performance when answering mundane, everyday questions posed by their family members during dinnertime interaction. Ethnographic observations and video recordings of spontaneous interaction at home reveal that, contrary to findings in cognitive psychological research, the majority of the time the children were able to detect their interlocutors’ communicative intentions and produce relevant responses that were marked by their conversational partners as acceptable. This article proposes that this success is due in part to parents who, through different strategies, facilitate their HFA and AS children’s access to socio-cultural perspective-taking and their interlocutors’ intentions, and better their children’s communicative skills.
The analgesic efficacy of peritubal infiltration of 0.25% bupivacaine in percutaneous nephrolithotomy — A prospective randomized study

Background: Percutaneous nephrolithotomy is a routine endourologic procedure in patients with renal stones. Although it is less painful than open surgery, good postoperative analgesia is required to alleviate pain around nephrostomy tube. Materials and Methods: Sixty ASA grade I patients, 18 to 60 years of age, of either sex were randomized to receive 20 ml of 0.25% bupivacaine (group S) or 20 ml of normal saline (group C) through 23-gauge spinal needle along the nephrostomy tube under fluroscopic guidance at the end of the surgery. Postoperative pain score was assessed by visual and dynamic visual analog scores. When the scores were ≥4, rescue analgesia was given in the form of tramadol 1 mg/kg i.v. upto maximum 400 mg in 24 hours. Time to first demand analgesia and total dose of tramadol in first 24 hours was noted. Results: Pain scores at rest and during coughing as well as rescue analgesic requirements for first 24 hours were significantly less in the bupivacaine group than those of the control group (P < 0.05). The first request for demand analgesia was around 9 hours in group S, while in group C it was around 2.6 hours (P < 0.05). Total requirement of tramadol in group S was 119.3 mg and in C group it was 276.8 mg (P < 0.05). Conclusion: Peritubal infiltration of 0.25% bupivacaine is efficient in alleviating postoperative pain after PCNL.
Molecular Cloning of the Leishmania major UDP-glucose Pyrophosphorylase, Functional Characterization, and Ligand Binding Analyses Using NMR Spectroscopy*

The dense glycocalyx surrounding the protozoan parasite Leishmania is an essential virulence factor. It protects the parasite from hostile environments in the sandfly vector and mammalian host and supports steps of development and invasion. Therefore, new therapeutic concepts concentrate on disturbing glycocalyx biosynthesis. Deletion of genes involved in the metabolism of galactose and mannose have been shown to drastically reduce Leishmania virulence. Here we report the identification of Leishmania major UDP-glucose pyrophosphorylase (UGP). UGP catalyzes the formation of UDP-glucose from glucose 1-phosphate and UTP. This activation step enables glucose to enter metabolic pathways and is crucial for the activation of galactose. UDP-galactose is made from UDP-glucose by nucleotide-donor transfer to galactose 1-phosphate or by epimerization of the glucose moiety. Isolated in a complementation cloning approach, the activity of L. major UGP was proven in vitro. Moreover, purified protein was used to investigate enzyme kinetics, quaternary organization, and binding of ligands. Whereas sequestration by oligomerization is a known regulatory mechanism for eukaryotic UGPs, the recombinant as well as native L. major UGP migrated as monomer in size exclusion chromatography and in accord with this showed simple Michaelis-Menten kinetics toward all substrates. In saturation transfer difference (STD)-NMR studies, we clearly demonstrated that the molecular geometry at position 4 of glucose is responsible for substrate specificity. Furthermore, the γ-phosphate group of UTP is essential for binding and for induction of the open conformation, which then allows entry of glucose 1-phosphate. Our data provide the first direct proof for the ordered bi-bi mechanism suggested in earlier studies.
Readers’ Responses When Characters Act on Completed Goals: Impact of Characters’ Mental States and Readers’ Task Focus

Research has demonstrated that readers track the objective status of characters' goals (i.e., whether the goals have been completed). We suggest that readers also use characters' subjective representations—characters' mental states with respect to goals—to comprehend actions. We explored circumstances in which local information about characters' subjective representation of a goal mismatched global information about the goal's objective status. In Experiments 1 and 2, we found that reading times were always affected by local information about characters' subjective representations but were unaffected by global information about objective goal status. In Experiments 3a and 3b, we asked participants to make judgments about characters' actions. We found that readers' judgments were affected both by global information about goal completion and by characters' subjective representations. These studies provide evidence that readers attend to characters' subjective representations of their goals and that different tasks affect whether readers focus on local or global information.
Family Social Networks and Recovery From Severe Mental Illness of Clubhouse Members

This study examined the contribution of family social network variables to recovery among Clubhouse members. A random sample of 118 members from one Clubhouse was recruited for this cross-sectional study. Among all respondents, greater overall family support and better relationship quality with the most supportive network member were correlated with greater levels of recovery. Clubhouse members perceived higher quantity and quality of support and more criticalness from their most supportive network members, principally family members, compared to the rest of their family members. Longitudinal studies are needed to further investigate the relationship between family support and recovery.
Psychological Risk Factors of Sudden Cardiac Arrest

This study tested the hypotheses that Vital Exhaustion (VE) increases the risk of sudden cardiac arrest (SCA) and that non-expression of emotions modifies the risk of VE. Data came from 99 victims of SCA and 103 healthy controls matched for gender and age. Victims of SCA were more often assessed as exhausted and as being closed by their family members than controls, the estimated relative risks being 2.81 (95% CI 1.1-7.3) and 2.28 (95% CI 1.1-4.6), respectively. No significant interaction between exhaustion and being closed on the risk of SCA was observed. These findings indicate that a state of exhaustion and being closed belong to the risk indicators of SCA.
‘Our way of life is worth defending’: testing a model of attitudes towards superordinate group membership through a study of Scots' attitudes towards Britain

This research used a survey design (N = 227) to investigate Scottish people's support or opposition to independence from Britain. It was hypothesised that political attitudes towards supra-national bodies are not a direct function of the degree of ingroup (Scottish) identification, but are moderated by the extent to which the expression of ingroup identity is seen as being undermined within the larger entity. This feeling of identity undermining is assumed to arise from perceptions of incompatibility with the outgroup and ingroup powerlessness within the common group. The results provided support for these hypotheses. Only for those participants who had high feelings of identity undermining did identification lead to stronger separatist attitudes. Moreover, incompatibility with the outgroup and ingroup powerlessness predicted feelings of identity undermining while this latter mediated their impact on attitudes to being part of Britain. These findings underline the importance of taking into account (a) the contents ascribed to identities and their relations, and (b) the practical ability to pursue a way of live based on these contents in order to understand the way identity processes shape attitudes towards superordinate groups. Copyright © 2008 John Wiley & Sons, Ltd.
Maternal Sensitivity: Components and Relations to Warmth and Contingency

Objective. In this article, maternal sensitivity as a measure of parenting quality is analyzed for (1) situational independence, (2) interrelations among components of sensitivity (signal perception, correct interpretation, prompt, and appropriate reaction), and (3) relations to emotional warmth and behavioral contingency. Design. The interactions of 60 mother - infant pairs at 3 months were videotaped in contexts of caregiving and free-play in their homes. Maternal sensitivity and its components were evaluated separately in each context and in combination. Maternal emotional warmth and behavioral contingency were considered in terms of their effects on both positive and negative infant signals. Results. Maternal sensitivity ratings reflected in free-play interactions were more consistent with the general measure from both contexts than was the case for caregiving interactions. The components of sensitivity were interrelated, indicating a unified understanding of the concept of sensitivity by the raters. Conclusions. Maternal emotional warmth during the expression of positive infant signals seems to be related to maternal sensitivity. In contrast, maternal emotional warmth during the expression of negative infant signals, and contingency in general, do not seem to be related to sensitivity. This study contributes to understanding the concept of maternal sensitivity and demonstrates that it can be closely related to maternal warmth during the expression of positive infant signals.
Distinct risk factors of atrial fibrillation in patients with and without coronary artery disease: a cross-sectional analysis of the BOREAS-CAG Registry data

Objective Although risk factors of atrial fibrillation (AF) in the general population have been characterised, their impacts on patients with specific diseases are unclear. Our aim was to determine whether risk factors of AF are different in patients with and those without coronary artery disease (CAD). Methods We enrolled 1871 consecutive patients who underwent coronary angiography for evaluation of symptoms suggestive of CAD in the BOREAS-CAG Registry between August 2014 and January 2015. After exclusion of patients with valvular heart disease or a history of PCI/cardiac surgery, 1150 patients contributed to multivariate logistic regression analysis to identify risk factors of AF. We also retrieved data for 361 consecutive patients with CAD admitted to Sapporo Medical University Hospital between April 2013 and July 2014 and analysed data for 166 patients using the same inclusion and exclusion criteria as those in the BOREAS-CAG Registry. Results Unexpectedly, CAD was independently associated with the absence of AF. The patients were then divided into a non-CAD group (n=576) and a CAD group (n=574) for further analysis. The brain natriuretic peptide level showed a strong association with AF regardless of the presence or absence of CAD. In the non-CAD group, lack of statin use was independently associated with AF, whereas high serum uric acid level was an independent explanatory variable of AF in the CAD group. The association of AF with uric acid was confirmed in a separate group of patients (n=166) enrolled in the CAD cohort in Sapporo Medical University Hospital. Conclusions Major risk factors of AF are different in patients with CAD and those without CAD. Patients with CAD are more likely to develop AF when the serum uric acid level is high, whereas no statin administration predicts development of AF in patients without CAD.
Comments on Assimilation Theory and the Reversed Müller—Lyer Illusion

This paper is a comment on the preceding paper in this issue by Pressey and Bross. The author reviews his position on the reversed Müller–Lyer illusion in which the illusion is explained in terms of the ‘enclosing nature’ of the ingoing fins. The two difficulties with this explanation pointed out by Pressey and Bross are discussed. Recent experimental work on the effects of enclosures is reported. A critique of Pressey and Bross's explanation of the reversed Müller–Lyer illusion is presented.
Patterns of attachment and alcohol abuse in sexual and violent non-sexual offenders

Abstract Two studies related to substance abuse and sexual offending were conducted. In the first study, a sample of 94 sexual offenders and 21 violent non-sexual offenders, incarcerated within the Ontario Region of Correctional Service of Canada (CSC), were administered the Michigan Alcohol Screening Test (MAST), the Drug Abuse Screening Test (DAST) and the Relationship Styles Questionnaire (RSQ). The Hare Psychopathy Checklist–Revised (PCL-R) was also scored for the majority of offenders included in the present study. Results indicated that the groups differed on PCL-R score, with both rapists and violent non-sexual offenders scoring significantly higher than the child molesters with reference to total PCL-R score. Sex offenders’ mean score on the MAST were significantly higher than those of the violent non-sexual offenders. The mean score on the MAST for sex offenders was in the problem drinking range. With reference to attachment pattern, sex offenders were found to be more preoccupied than violent non-sexual comparison subjects. In the second study, a sample of sexual offenders, all of whom exhibited elevated levels of alcohol abuse as measured by the MAST, were divided into two groups based on whether or not they had completed a substance abuse treatment programme. Sexual offenders (all of whom received sex offender-specific treatment) who also received substance abuse treatment evidenced significantly lower levels of general recidivism than those who did not complete such treatment. Results are discussed in light of previous findings in relation to differing patterns of substance abuse between sexual and violent non-sexual offenders observed in the literature as well as with reference to Marshall's attachment theory.
On the identity of the fossil aquatic beetles from the Tertiary localities in the southern part of the Upper Rhine Graben (Coleoptera, Hydrophilidae, Dytiscidae)

Abstract This study focuses on the fossil beetles assigned previously to the family Hydrophilidae described from the localities in the southern part of the Upper Rhine Graben: Brunstatt (France, Alsace) and Kleinkems (Germany, Baden-Württemberg) (both dated ca. to Eocene-Oligocene boundary, 34 Ma). The identity of Escheria convexa Förster, 1891 is fixed by the designation of its neotype, the species is redescribed, illustrated, transferred from the hydrophilid genus Hydrobius Leach, 1815 to the genus Copelatus Erichson, 1832 (Coleoptera: Adephaga: Dytiscidae) and compared with other fossil representatives of Copelatus. The identity of the remaining three species, Hydrobius crassipunctatus (Förster, 1891), Hydrobius dimidiatus (Förster, 1891) and Hydrobius punctulatus (Förster, 1891),is briefly evaluated on the basis of the original descriptions and illustrations only, because their types were lost or destroyed during World War II; all three species are removed from the fossil record of the Hydrophiloidea and placed into Polyphaga incertae sedis. The geology and stratigraphy of Brunnstatt and Kleinkems are discussed briefly.
How the Shape of Pre- and Postsynaptic Signals Can Influence STDP: A Biophysical Model

Spike-timing-dependent plasticity (STDP) is described by long-term potentiation (LTP), when a presynaptic event precedes a postsynaptic event, and by long-term depression (LTD), when the temporal order is reversed. In this article, we present a biophysical model of STDP based on a differential Hebbian learning rule (ISO learning). This rule correlates presynaptically the NMDA channel conductance with the derivative of the membrane potential at the synapse as the postsynaptic signal. The model is able to reproduce the generic STDP weight change characteristic. We find that (1) The actual shape of the weight change curve strongly depends on the NMDA channel characteristics and on the shape of the membrane potential at the synapse. (2) The typical antisymmetrical STDP curve (LTD and LTP) can become similar to a standard Hebbian characteristic (LTP only) without having to change the learning rule. This occurs if the membrane depolarization has a shallow onset and is long lasting. (3) It is known that the membrane potential varies along the dendrite as a result of the active or passive backpropagation of somatic spikes or because of local dendritic processes. As a consequence, our model predicts that learning properties will be different at different locations on the dendritic tree. In conclusion, such site-specific synaptic plasticity would provide a neuron with powerful learning capabilities.
Automatic Detection of Key Innovations, Rate Shifts, and Diversity-Dependence on Phylogenetic Trees

A number of methods have been developed to infer differential rates of species diversification through time and among clades using time-calibrated phylogenetic trees. However, we lack a general framework that can delineate and quantify heterogeneous mixtures of dynamic processes within single phylogenies. I developed a method that can identify arbitrary numbers of time-varying diversification processes on phylogenies without specifying their locations in advance. The method uses reversible-jump Markov Chain Monte Carlo to move between model subspaces that vary in the number of distinct diversification regimes. The model assumes that changes in evolutionary regimes occur across the branches of phylogenetic trees under a compound Poisson process and explicitly accounts for rate variation through time and among lineages. Using simulated datasets, I demonstrate that the method can be used to quantify complex mixtures of time-dependent, diversity-dependent, and constant-rate diversification processes. I compared the performance of the method to the MEDUSA model of rate variation among lineages. As an empirical example, I analyzed the history of speciation and extinction during the radiation of modern whales. The method described here will greatly facilitate the exploration of macroevolutionary dynamics across large phylogenetic trees, which may have been shaped by heterogeneous mixtures of distinct evolutionary processes.
The influence of code-oriented versus meaning-oriented approaches to reading instruction on word recognition in the Spanish language

This study was designed to examine the possible effect of instructional method and grade on the development of the competences used in reading isolated words in a transparent orthography (i.e., Spanish). A cross-sectional design was used with a sample of 202 children who were learning to read by different instructional methods (code-oriented vs. meaning-oriented approaches). The effect of instructional method was analysed on reaction times, latency responses, and misreading on lexical decision and naming tasks. Words varied in frequency, length, and positional frequency of syllables (PFS) and the nonwords varied only in length and PFS. Our prediction was that the differences in reaction times and error performance as a function of the variables that allow us to test the routes-- such as lexicality, word frequency, PFS, and word length--would be greater in the individuals who learn by a meaning-oriented approach, which means that this group would be more affected by unfamiliar and longer words, low PFS, an.