Miracle-dz/UniFAR-FTUs huggingface dataset:
Mapping the Intermedilysin-Human CD59 Receptor Interface Reveals a Deep Correspondence with the Binding Site on CD59 for Complement Binding Proteins C8α and C9*

CD59 is a glycosylphosphatidylinositol-anchored protein that inhibits the assembly of the terminal complement membrane attack complex (MAC) pore, whereas Streptococcus intermedius intermedilysin (ILY), a pore forming cholesterol-dependent cytolysin (CDC), specifically binds to human CD59 (hCD59) to initiate the formation of its pore. The identification of the residues of ILY and hCD59 that form their binding interface revealed a remarkably deep correspondence between the hCD59 binding site for ILY and that for the MAC proteins C8α and C9. ILY disengages from hCD59 during the prepore to pore transition, suggesting that loss of this interaction is necessary to accommodate specific structural changes associated with this transition. Consistent with this scenario, mutants of hCD59 or ILY that increased the affinity of this interaction decreased the cytolytic activity by slowing the transition of the prepore to pore but not the assembly of the prepore oligomer. A signature motif was also identified in the hCD59 binding CDCs that revealed a new hCD59-binding member of the CDC family. Although the binding site on hCD59 for ILY, C8α, and C9 exhibits significant homology, no similarity exists in their binding sites for hCD59. Hence, ILY and the MAC proteins interact with common amino acids of hCD59 but lack detectable conservation in their binding sites for hCD59.
Making sense of pre-service teachers’ dispositions towards social justice: can teacher education make a difference?

Given Australia's diverse student population, the need for pre-service teacher education to prepare what is a predominantly Anglo-Australian and middle-class profession to be effective teachers of diverse students is critical. In Lortie's (1975) classic study, however, he argues that the predispositions of teacher education students are a much more powerful socialising influence than pre-service education. This article explores dispositions towards social justice in pre-service teachers from two teacher education programs within one Australian metropolitan university. Drawing on notions of distributive, retributive and recognitive justice (Gale & Densmore, 2000) as a way of making sense of socially just dispositions, interviews with four pre-service teachers – two beginning their Graduate Diploma in Education program (a one year program) and two beginning their final year of the Bachelor of Education program (a four year program) – are analysed. Differences in the dispositions of teachers from the two cohorts are examined and implications for teacher education discussed.
Spirituality and the treatment of substance use disorders: An exploration of forgiveness, resentment and purpose in life

Faith-based treatment programs are a viable treatment option for many individuals with substance use disorders; however, the psychological mechanisms that explain the relationship between spirituality and a recovery from substance use disorders have not been established. The Spirituality, Forgiveness, and Purpose (SFP) model of recovery proposes that forgiveness and purpose in life may mediate the spirituality–recovery relationship. As a preliminary step in exploring this theory, a cross-sectional investigation of 277 clients of the Australian Salvation Army Rehabilitation Service Centres was performed. A multiple regression found that forgiveness of others, forgiveness of self, receiving forgiveness from others, and receiving forgiveness from God predicted resentment. Furthermore, multiple mediation analyses found that forgiveness of self and receiving forgiveness from others and God mediated the relationship between daily spiritual experiences and purpose and engagement in life.
Neuroscience and Biobehavioral Reviews Review Mirror-sensory Synaesthesia: Exploring 'shared' Sensory Experiences as Synaesthesia

Recent research suggests the observation or imagination of somatosensory stimulation in another (e.g., touch or pain) can induce a similar somatosensory experience in oneself. Some researchers have presented this experience as a type of synaesthesia, whereas others consider it an extreme experience of an otherwise normal perception. Here, we present an argument that these descriptions are not mutually exclusive. They may describe the extreme version of the normal process of understanding somatosen-sation in others. It becomes synaesthesia, however, when this process results in a conscious experience comparable to the observed person's state. We describe these experiences as 'mirror-sensory synaesthe-sia'; a type of synaesthesia identified by its distinct social component where the induced synaesthetic experience is a similar sensory experience to that perceived in another person. Through the operational-isation of this intriguing experience as synaesthesia, existing neurobiological models of synaesthesia can be used as a framework to explore how mechanisms may act upon social cognitive processes to produce conscious experiences similar to another person's observed state.
On requirements verification for model refinements

Conventional formal verification techniques rely on the assumption that a system's specification is completely available so that the analysis can say whether or not a set of properties will be satisfied. On the contrary, modern development lifecycles call for agileincremental and iterativeapproaches to tame the boosting complexity of modern software systems and reduce development risks. We focus here on requirements verification performed in the early exploratory stages on high-level models and we discuss how this can be integrated into an agile approach. We present a new technique to model-check incomplete high-level specifications against formally specified requirements. We do this in the context of incomplete hierarchical Statecharts, verified against a variation of CTL properties. Our approach supports step-wise specification and refinement verification. Verification can be incremental, that is alternative refinements may be separately explored and verification is only replayed for the modified parts. The results are presented by introducing the formalisms, the model-checking algorithm, and the tool we have implemented.
ATTITUDE VERSUS GENERAL HABIT -- ANTECEDENTS OF TRAVEL MODE CHOICE /

A model of travel mode choice is tested by means of a survey among 199 inhabitants of a village. Car choice behavior for a particular journey is predicted from the attitude toward choosing the car and the attitude toward choosing an alternative mode (i.e., train), on the one hand, and from general car habit, on the other hand. Unlike traditional measures of habit, a script-based measure was used. General habit was measured by travel mode choices in response to very global descriptions of imaginary journeys. In the model, habit is predicted from the degree of involvement with the decision-making about travel mode choice for the particular journey (decisional involvement) and from the degree of competition in a household with respect to car use. The model proves satisfactory. Moreover, as suggested by Triandis (1977), there is a tradeoff between attitude and habit in the prediction of behavior: When habit is strong the attitude-behavior relation is weak, whereas when habit is weak, the attitude-behavior link is strong.
The reciprocal relations between self-concept, motivation and achievement: juxtaposing academic self-concept and achievement goal orientations for mathematics success

Research suggests that motivated students and those with high academic self-concepts perform better academically. Although substantial evidence supports a reciprocal relation between academic self-concept and achievement, there is less evidence supporting a similar relation between achievement goal orientations and achievement. There is also a paucity of research testing the longitudinal relations between achievement goal orientations and academic self-concept with achievement. The present investigation aimed to contribute to addressing these limitations. The sample consisted of 2786 Australian high school students (ages 11–17) measured at four time waves six months apart. Separate models indicated reciprocal relations between mathematics self-concept and achievement and mathematics performance approach goal orientation and achievement. There was little evidence of reciprocal relations between a mastery approach goal orientation and achievement. Juxtaposing the variables, when all were included in a single model, only self-concept had significant reciprocal relationships with achievement.
Young Adolescent Boys and Dating Violence

This study investigated gender and age differences in the perceptions of dating violence using both qualitative and quantitative research methods. Focus groups were conducted to develop culturally appropriate questionnaires consisting of dating scenarios that may lead to dating violence. The participants were asked to provide their perceptions and behavioral reactions to the dating scenarios. The study found that young adolescent boys were significantly more likely to respond aggressively toward dating partners than were young adolescent girls, women, and men. These findings have implications for practitioners who are charged with preventing dating violence among adolescents, specifically boys.
The C Allele of rs5743836 Polymorphism in the Human TLR9 Promoter Links IL-6 and TLR9 Up-Regulation and Confers Increased B-Cell Proliferation

In humans, allelic variants in Toll-like receptors (TLRs) associate with several pathologies. However, the underlying cellular and molecular mechanisms of this association remain largely unknown. Analysis of the human TLR9 promoter revealed that the C allele of the rs5743836 polymorphism generates several regulatory sites, including an IL-6-responding element. Here, we show that, in mononuclear cells carrying the TC genotype of rs5743836, IL-6 up-regulates TLR9 expression, leading to exacerbated cellular responses to CpG, including IL-6 production and B-cell proliferation. Our study uncovers a role for the rs5743836 polymorphism in B-cell biology with implications on TLR9-mediated diseases and on the therapeutic usage of TLR9 agonists/antagonists.
The Reset Inflation Puzzle and the Heterogeneity in Price Stickiness

New Keynesian models have been criticised on the grounds that they require implausibly large price shocks to explain inflation. Bils et al. (2012) show that, while these shocks are needed to reduce the excessive inflation persistence generated by the models, they give rise to unrealistically volatile reset price inflation. This paper shows that introducing heterogeneity in price stickiness in the models overcomes these criticisms directed at them. The incorporation of heterogeneity in price stickiness reduces the need for large price shocks. With smaller price shocks, the new model comes close to matching the data on reset inflation.
The Impact of Bimodal Bilingual Parental Input on the Communication and Language Development of a Young Deaf Child

Abstract This study explores the impact of bimodal bilingual parental input on the communication and language development of a young deaf child. The participants in this case study were a severe-to-profoundly deaf boy and his hearing parents, who were enrolled in a bilingual (English and Australian Sign Language) home-based early intervention programme. The parents typified the challenges faced by hearing parents of deaf children seeking to provide a bimodal language environment for their deaf child. Data were collected over 20 months when the boy was aged between 23 and 42 months. The parents' level of Auslan proficiency, bilingual practice, and sensitivity to their son's communication needs were measured. Findings indicated that although communication and language outcomes were delayed compared with hearing peers, English and Auslan vocabulary growth over time was strongly correlated with the parents' sensitivity to his communication needs. Findings also indicated that there were several child-led changes in language modality preferences throughout the study.
A Moment of Mindfulness: Computer-Mediated Mindfulness Practice Increases State Mindfulness

Three studies investigated the use of a 5-minute, computer-mediated mindfulness practice in increasing levels of state mindfulness. In Study 1, 54 high school students completed the computer-mediated mindfulness practice in a lab setting and Toronto Mindfulness Scale (TMS) scores were measured before and after the practice. In Study 2 (N = 90) and Study 3 (N = 61), the mindfulness practice was tested with an entirely online sample to test the delivery of the 5-minute mindfulness practice via the internet. In Study 2 and 3, we found a significant increase in TMS scores in the mindful condition, but not in the control condition. These findings highlight the impact of a brief, mindfulness practice for single-session, computer-mediated use to increase mindfulness as a state.
Clinical risk factors for venous thrombosis associated with air travel.

BACKGROUND Recent reports have linked air travel with venous thrombo-embolism (VTE). Risk factors and associated features of this link are poorly understood. We have accumulated clinical data from a relatively large cohort of patients with traveler's thrombosis. METHODS A total of 86 patients who developed venous thromboembolism within 28 d of flying were questioned concerning traveling habits, medical history (including risk factors for VTE) and characteristics of the index flight. RESULTS Of the patients, 72% had at least one risk factor for VTE (excluding thrombophilia) prior to their flight. Of interest, 87% of VTE cases occurred following either a return trip or after an outward journey involving long trips made up of sequential flights. In only two cases could no identifiable risk factor or earlier journey be found. Duration of flights ranged from 2 to 30 h. Of responders, 38% presented with chest symptoms; 92% with VTE developed symptoms within 96 h of their flight. CONCLUSION We conclude that the majority of VTE associated with air travel occur in those with identifiable risk factors prior to their flight, and that sequential flights may increase this risk.
Serological Studies in Infectious Mononucleosis

Serological investigations performed on 27 patients with illnesses resembling infectious mononucleosis showed a significant increase in high antibody titres (more than 1:40) to EB virus in 11 of the 12 who developed heterophile antibodies. Two of these patients, however, had a significant increase in antibody titre to cytomegalovirus and rubella virus, respectively. Of 15 patients who failed to develop heterophile antibodies, one had a high antibody titre to EB virus, the others generally having undetectable or low antibody titres. The insidious onset of the illness in many patients together with the fact that EB virus antibodies rose to high titres rapidly reduced the value of this investigation diagnostically. EB virus antibody was still present in the sera of five patients who had had well-authenticated heterophile-antibody-positive infectious mononucleosis some four to seven years previously. Twenty-seven out of 70 (39%) healthy nurses had antibody at a level of more than 1:10 to EB virus. The presence of EB virus antibody in different population groups appears to be related to such factors as age and socioeconomic status.
Beneficial role of celery oil in lowering the di(2-ethylhexyl) phthalate-induced testicular damage

Di(2-ethylhexyl) phthalate (DEHP), the most abundant phthalate in the environment, is known to be a reproductive toxicant. Considering the therapeutic significance of medicinal plants, this study was conducted to evaluate the effects of administration of celery oil on DEHP-induced testicular toxicity. The experiment was carried out for 8 weeks on 36 male rats that were divided equally into six groups. Group 1 was kept as normal control (given vehicle), while rats of group 2 were administered orally 200 mg/kg/day of celery oil. Groups 3 and 5 were orally given 500 and 1000 mg DEHP/kg/day, respectively. Groups 4 and 6 were treated with similar doses of DEHP as in groups 3 and 5 plus celery oil (200 mg/kg/day). Body and testicular weights, sperm parameters, serum hormones (testosterone, follicle-stimulating hormone, luteinizing hormone and estradiol), antioxidant enzymes (superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT)) and expression of cytochrome P450 aromatase (CYP19) messenger RNA (mRNA) were investigated at the end of 8th week. Treatment with DEHP alone resulted in a significant decrease in body and testicular weights, sperm parameters and serum hormone levels when compared with control. On the other hand, testicular antioxidant enzymes showed a significant dose-dependent increase. The expression of CYP19 mRNA was significantly reduced by increasing the doses of DEHP. Administration of celery oil along with DEHP partially prevented the decrease in body and testicular weights and enhanced epididymal sperm count, serum hormone levels and the expression of CYP19 mRNA along with diminution in the activities of SOD, GPx and CAT enzymes. The obtained results showed that the celery improved the testicular alterations induced by DEHP in albino rats.
Gauge theory in dimension $7$

We first review the notion of a $G_2$-manifold, defined in terms of a principal $G_2$ ("gauge") bundle over a $7$-dimensional manifold, before discussing their relation to supergravity. In a second thread, we focus on associative submanifolds and present their deformation theory. In particular, we elaborate on a deformation problem with coassociative boundary condition. Its space of infinitesimal deformations can be identified with the solution space of an elliptic equation whose index is given by a topological formula.
Impression Management: Developing and Illustrating a Scheme of Analysis for Narrative Disclosures - A Methodological Note

Purpose - This paper develops a holistic measure for impression management and for bias introduced into corporate narratives as a result of impression management.Design/Methodology/Approach - Prior research on the seven impression management methods in the literature is summarised. Four of the less-researched methods are described in detail, and are illustrated with examples from UK Annual Results' Press Releases (ARPRs). A method of computing a holistic composite impression management score based on these four impression management methods is developed, based on both quantitative and qualitative data in corporate narrative disclosures. A bias score is devised to capture the extent to which impression management introduces bias into corporate narratives. An example of the application of the composite impression management score and bias score methodology is provided.Findings - While not amounting to systematic evidence, the 21 illustrative examples suggest that impression management is pervasive in corporate financial communications using multiple impression management methods, such that positive information is exaggerated, while negative information is either ignored or is underplayed.Originality/Value - Four impression management methods are described in detail, illustrated by 21 examples. These four methods are examined together. New impression management methods are studied in this paper for the first time. This paper extends prior impression management measures in two ways. First, a composite impression management score based on four impression management techniques is articulated. Second, the composite impression management score methodology is extended to capture a measure for bias. This is the first time outside the US that narrative disclosures in press releases have been studied.
Thinking Matters: Inferencing in ESL Reading Lessons

This article discusses the significance of inferencing in reading comprehension and addresses theoretical and practical issues related to teaching inferencing in English classrooms. The author explains the nature of inferencing in reading and, drawing on previous research findings and his own reflections on teaching reading to English as a second language (ESL) students, proposes a framework in which inferencing is taught via an explicit instruction approach. A sample lesson is included. Although the focus is on inferencing in an ESL context, the discussion has implications for the general English learning domain.
Money Work, Fast Money and Prize Money: Aspects of the Tahitian Labor Commitment

The expansion of market-oriented and industrially organized activities over the world entails a revolutionary change in mode of livelihood for literally millions of people. Those formerly dependent on subsistence and cash crop production are rapidly turning to wage labor. This growing labor commitment - to borrow a term from Moore and Feldman - by which is meant the wholehearted acceptance of wage labor as a permanent mode of livelihood, is a process that demands the attention of all social scientists. I believe that anthropologists have a unique contribution to make in understanding labor commitment among the various peoples of the world. Their tradition of lengthy study, of learning the local language, and of analyzing their subjects' categories can be used with profit in such situations. They should go beyond statistics on labor involvement, or questionnaire-elicited "attitudes," and focus on how people perceive work, and the alternative modes of employment open to them. One of their goals should be to.
Extraction of the Pomeron Trajectory from a Global Fit to Exclusive rho0 Meson Photoproduction Data

Based on data on elastic � 0 photoproduction from the H1, Omega and ZEUS collabora- tions, a fit has been performed to extract the valueP (t) of the pomeron trajectory at fixed values of t from the W dependence of the differential p cross section dp (W)/dt. The data used in the fit cover the range of 8.3 � W � 94GeV in p centre-of-mass energy and 0.01 � |t| � 0.95GeV 2 in momentum transfer. A linear fit to the resulting values ofP (t) yieldsP,0 = 1.0871 ± 0.0026(stat.) ± 0.0030(syst.) for the intercept and � ' = 0.126 ± 0.013(stat.) ± 0.012(syst.)GeV −2 for the slope of the pomeron trajectory. The data are also compatible with the Donnachie- Landshoff trajectoryP (t) = 1.0808 + 0.25GeV −2 · t at low values |t| . 0.3GeV 2 and with a constant value ofP (t) at larger values of |t|.