Miracle-dz/UniFAR-FTUs huggingface dataset:
Boosting Lazy Decision Trees

This paper explores the problem of how to construct lazy decision tree ensembles. We present and empirically evaluate a relevance-based boosting-style algorithm that builds a lazy decision tree ensemble customized for each test instance. From the experimental results, we conclude that our boosting-style algorithm significantly improves the performance of the base learner. An empirical comparison to boosted regular decision trees shows that ensembles of lazy decision trees achieve comparable accuracy and better comprehensibility. We also introduce a novel distance-based pruning strategy for the lazy decision tree algorithm to address the problem of over-fitting. Our experiments show that the pruning strategy improves the accuracy and comprehensibility of both single lazy decision trees and boosted ensembles.
Air-float Palpation Probe for Tissue Abnormality Identification During Minimally Invasive Surgery

This paper presents a novel palpation probe based on optical fiber technology. It is designed to measure stiffness distribution of a soft tissue while sliding over the tissue surface in a near frictionless manner. A novelty of the probe is its ability to measure indentation depth for nonplanar tissue profiles which are commonly experienced during surgery. Since tumors are often harder than the surrounding tissue, the proposed probe can intraoperatively aid the surgeon to rapidly identify the presence, location, and size of the tumors through the generation of a tissue stiffness map. The probe can concurrently measure tissue reaction force, indentation depth, and the orientation of the probe with respect to the tissue surface. Hence, it can generate an elasticity model of the tissue with minimum measurement inaccuracies caused by surface profile variations. Further, the probe has a tunable force range and the indentation force can be adjusted externally to match tissue limitations. The performance of the probe developed was validated using simulated soft tissues samples. Our tumor identification experiments showed that the probe can accurately identify the location and size of tumors hidden inside nonflat tissue surfaces. Further, the probe has clearly demonstrated its potential to identify tumors with tumor-tissue stiffness ratios as low as 2.1.
K+-Dependent Selectivity and External Ca2+ Block of Shab K+ Channels

Potassium channels allow the selective flux of K+ excluding the smaller, and more abundant in the extracellular solution, Na+ ions. Here we show that Shab is a typical K+ channel that excludes Na+ under bi-ionic, Nao/Ki or Nao/Rbi, conditions. However, when internal K+ is replaced by Cs+ (Nao/Csi), stable inward Na+ and outward Cs+ currents are observed. These currents show that Shab selectivity is not accounted for by protein structural elements alone, as implicit in the snug-fit model of selectivity. Additionally, here we report the block of Shab channels by external Ca2+ ions, and compare the effect that internal K+ replacement exerts on both Ca2+ and TEA block. Our observations indicate that Ca2+ blocks the channels at a site located near the external TEA binding site, and that this pore region changes conformation under conditions that allow Na+ permeation. In contrast, the latter ion conditions do not significantly affect the binding of quinidine to the pore central cavity. Based on our observations and the structural information derived from the NaK bacterial channel, we hypothesize that Ca2+ is probably coordinated by main chain carbonyls of the pore´s first K+-binding site.
Semi-Supervised Regression using Spectral Techniques

Graph-based approaches for semi-supervised learning have received increasing amount of interest in recent years. Despite their good performance, many pure graph based algorithms do not have explicit functions and can not predict the label of unseen data. Graph regularization is a recently proposed framework which incorporates the intrinsic geometrical structure as a regularization term. It can be performed as semi-supervised learning when unlabeled samples are available. However, our theoretical analysis shows that such approach may not be optimal for multi-class problems. In this paper, we propose a novel method, called Spectral Regression (SR). By using spectral techniques, we first compute a set of responses for each sample which respects both the label information and geometrical structure. Once the responses are obtained, the ordinary ridge regression can be apply to find the regression functions. Our proposed algorithm is particularly designed for multi-class problem. Experimental results on two real world classification problems arising in visual and speech recognition demonstrate the effectiveness of our algorithm.
Speeding-Up the Similarity Search in Time Series Databases by Coupling Dimensionality Reduction Techniques with a Fast-and-Dirty Filter

in this paper we present a new generic frame that boosts the performance of different time series dimensionality reduction techniques by using a fast-and-dirty filter that we combine with the lower bounding condition of the dimensionality reduction technique to increase the pruning power. This fast-and-dirty filter is based on an optimal approximation of the segmented time series. The distances between these segmented time series and their approximating functions are computed and stored at indexing-time. This step is repeated using different resolution levels which correspond to different lengths of the segments. At query-time these pre-computed distances are utilized to prune those time series which are not similar to the given pattern using the least number of query-time distance computations. We conduct experiments that validate the theoretical basis of our proposed method.
Influence of Processing Conditions on the Electrical Properties of CaCu3Ti4O12 Ceramics

The electrical properties of a series of CaCu3Ti4O12 ceramics prepared by the mixed oxide route and sintered at 1115°C in air for 1–24 h to produce different ceramic microstructures have been studied by Impedance Spectroscopy. As-fired ceramics are electrically heterogeneous, consisting of semiconducting grains and insulating grain boundaries, and can be modelled to a first approximation on an equivalent circuit based on two parallel RC elements connected in series. The grain boundary resistance and capacitance values vary as a function of sintering time and correlate with the ceramic microstructure based on the brickwork layer model for electroceramics. The large range of apparent high permittivity values for CaCu3Ti4O12 ceramics is therefore attributed to variations in ceramic microstructure. The grain-boundary resistance decreases by three to four orders of magnitude after heat treatment in N2 at 800°–1000°C but can be recovered to the original value by heat treatment in O2 at 1000°C. The bulk resistivity decreases from ∼80 to 30 Ω·cm with increasing sintering time but is independent of heat treatment in N2 or O2 at 800°–1000°C. The origin of the bulk semiconductivity is discussed and appears to be related to partial decomposition of CaCu3Ti4O12 at the high sintering temperatures required to form dense ceramics, and not to oxygen loss.
Mitochondrial Modulation by Epigallocatechin 3-Gallate Ameliorates Cisplatin Induced Renal Injury through Decreasing Oxidative/Nitrative Stress, Inflammation and NF-kB in Mice

Cancer chemotherapy drug cisplatin is known for its nephrotoxicity. The aim of this study is to investigate whether Epigallocatechin 3-Gallate (EGCG) can reduce cisplatin mediated side effect in kidney and to understand its mechanism of protection against tissue injury. We used a well-established 3-day cisplatin induced nephrotoxicity mice model where EGCG were administered. EGCG is a major active compound in Green Tea and have strong anti-oxidant and anti-inflammatory properties. EGCG protected against cisplatin induced renal dysfunction as measured by serum creatinine and blood urea nitrogen (BUN). EGCG improved cisplatin induced kidney structural damages such as tubular dilatation, cast formation, granulovaculoar degeneration and tubular cell necrosis as evident by PAS staining. Cisplatin induced kidney specific mitochondrial oxidative stress, impaired activities of mitochondrial electron transport chain enzyme complexes, impaired anti-oxidant defense enzyme activities such as glutathione peroxidase (GPX) and manganese superoxide dismutase (MnSOD) in mitochondria, inflammation (tumor necrosis factor α and interleukin 1β), increased accumulation of NF-κB in nuclear fraction, p53 induction, and apoptotic cell death (caspase 3 activity and DNA fragmentation). Treatment of mice with EGCG markedly attenuated cisplatin induced mitochondrial oxidative/nitrative stress, mitochondrial damages to electron transport chain activities and antioxidant defense enzyme activities in mitochondria. These mitochondrial modulations by EGCG led to protection mechanism against cisplatin induced inflammation and apoptotic cell death in mice kidney. As a result, EGCG improved renal function in cisplatin mediated kidney damage. In addition to that, EGCG attenuated cisplatin induced apoptotic cell death and mitochondrial reactive oxygen species (ROS) generation in human kidney tubular cell line HK-2. Thus, our data suggest that EGCG may represent new promising adjunct candidate for cisplatin.
Prognosis of Patients With Middle Cerebral Artery Occlusion

The long-term prognosis of 78 stroke patients with occlusion of the middle cerebral artery (MCA) or its branches is described. The mean age of the patients was 44 years. The mortality rate in the acute phase was 5%. The acute and total mortality rates of men were higher than those of women (p < 0.05). Life-table analysis gave 94% probability for one year's survival, 84% for three years' survival, and 78% for five years' survival. Subsequent strokes were twice as common as cardiovascular events as the cause of death. Seventytwo percent of the survivors became fully independent in activities of daily living (ADL), 27% required assistance, 1% was totally disabled, and 43% returned to work. Left-sided occlusion was overrepresented in those who died (p < 0.001) and those who returned to work (p < 0.05), and right-sided occlusion was overrepresented in those who required assistance in ADL (p < 0.05).
Overview of guidelines for the management of dyslipidemia: EU perspectives

Modern medicine is characterized by a continuous genesis of evidence making it very difficult to translate the latest findings into a better clinical practice. Clinical practice guidelines (CPG) emerge to provide clinicians evidence-based recommendations for their daily clinical practice. However, the high number of existing CPG as well as the usual differences in the given recommendations usually increases the clinician’s confusion and doubts. It has apparently been the case for the 2013 American College of Cardiology/American Heart Association (ACC/AHA) Guideline on the Treatment of Blood Cholesterol. These CPG proposed new and controversial concepts that have usually been considered an antagonist shift respective to European CPG. The most controversial published proposals are: 1) to consider evidence just from randomized clinical trials, 2) creation of a new cardiovascular (CV) risk calculator, 3) to consider reducing CV risk instead of reducing low-density lipoprotein cholesterol (LDLc) as the target of the treatment, and 4) consideration of statins as the only drugs for treatment. A deep analysis of the 2013 American College of Cardiology/American Heart Association CPG and comparison with the European ones show that from a practical and clinical point of view, there are more similarities than differences. To further help clinicians in their daily work, in the present globalized world, it is time to discuss and adopt a mutually agreed upon document created by both sides of the Atlantic. Probably it is not a short-term solution. Meanwhile, taking advantage of the similarities, the recommended practical attitude for the daily clinical practice should be based on 1) early detection of people with increased CV risk promoting the use of validated local scales, 2) reinforce the mainstream importance of nonpharmacological treatment, and 3) need for periodically monitoring response with analytical parameters (LDL or non-high-density lipoprotein cholesterol) and global CV risk estimation. Technological solutions such as the big data technology could help to obtain high-quality evidence in an intermediate term.
A Blessing and a Curse? Political Institutions in the Growth and Decay of Generalized Trust: A Cross-National Panel Analysis, 1980–2009

Despite decades of research on social capital, studies that explore the relationship between political institutions and generalized trust–a key element of social capital–across time are sparse. To address this issue, we use various cross-national public-opinion data sets including the World Values Survey and employ pooled time-series OLS regression and fixed- and random-effects estimation techniques on an unbalanced panel of 74 countries and 248 observations spread over a 29-year time period. With these data and methods, we investigate the impact of five political-institutional factors–legal property rights, market regulations, labor market regulations, universality of socioeconomic provisions, and power-sharing capacity–on generalized trust. We find that generalized trust increases monotonically with the quality of property rights institutions, that labor market regulations increase generalized trust, and that power-sharing capacity of the state decreases generalized trust. While generalized trust increases as the government regulation of credit, business, and economic markets decreases and as the universality of socioeconomic provisions increases, both effects appear to be more sensitive to the countries included and the modeling techniques employed than the other political-institutional factors. In short, we find that political institutions simultaneously promote and undermine generalized trust.
Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib

Bortezomib is a proteasome inhibitor producing high response rates in patients with relapsed/resistant multiple myeloma patients. This study investigates the effect of bortezomib on circulating angiopoietins levels, and shows that the normalization of the angiopoietin-1/angiopoietin-2 ratio reflects the response to treatment. Neoangiogenesis is involved in the pathophysiology of multiple myeloma and angiopoietins possibly contribute to myeloma-induced neovascularization. Bortezomib’s antineoplastic potential includes an anti-angiogenic effect. We determined serum levels of angiopoietin-1 and angiopoietin-2 with ELISA pre- and post-bortezomib administration in 35 patients with relapsed/refractory multiple myeloma. Pre-bortezomib, serum angiopoietin-1 levels did not differ in patients and in healthy individuals, while serum angiopoietin-2 levels were elevated. Corresponding serum angiopoietin-1/angiopoietin-2 ratio was reduced in patients compared with controls. After treatment, serum angiopoietin-1 levels increased, while serum angiopoietin-2 levels decreased, therefore the angiopoietin-1/angiopoietin-2 ratio increased and normalized. This increase was significant in patients who responded to treatment. In conclusion, angiopoietin-1/angiopoietin-2 ratio normalization reflected response to bortezomib.
Phonological acquisition in bilingual Spanish-English speaking children.

PURPOSE In this study, the authors aimed to determine how between-language interaction contributes to phonological acquisition in bilingual Spanish-English speaking children. METHOD A total of 24 typically developing children, ages 3;0 (years;months) to 4;0, were included in this study: 8 bilingual Spanish-English speaking children, 8 monolingual Spanish speakers, and 8 monolingual English speakers. Single word and connected speech samples were obtained for each child. This study examined interaction between the two languages of bilingual children during phonological acquisition through the measurement of (a) transfer (the frequency and types of phonological transfer present in the speech of bilingual children); (b) deceleration (a slower rate of acquisition for bilinguals as compared with monolinguals); and (c) acceleration (a faster rate of acquisition for bilinguals as compared with monolinguals. RESULTS Findings demonstrated that (a) transfer was evident in the productions of bilingual children, (b) differences were found in accuracy between monolingual and bilingual children, and (c) sound frequency did not predict differential accuracy of either phonetically similar sounds between languages or phonetically dissimilar sounds specific to Spanish or English. IMPLICATIONS The results from this study indicate that transfer, deceleration, and a possible variation of the acceleration hypothesis occur in bilingual phonological acquisition. Evidence was found for separation and interaction between the bilingual children's 2 languages (J. Paradis & F. Genesee, 1996).
Towards cooperation fairness in mobile ad hoc networks

For the sustainable operation of ad hoc networks, incentive mechanisms are required to encourage cooperation. More importantly, we must enforce available bandwidth fairness among nodes. Bandwidth sharing is fair if a node's available bandwidth is proportional to its forwarding contribution. In this paper, we achieve fair bandwidth sharing through a new packet scheduling algorithm, called cooperative queueing, on each node. In cooperative queueing, which is analogous to fair queueing, packet scheduling is based on a new abstraction that we call cooperation coefficient (CC). The CC quantifies how much a given node contributes to and consumes from the ad-hoc network; the larger the CC, the more bandwidth a node can obtain. We exploit the widely used dynamic source routing information to obtain the CC. We evaluate the effectiveness of cooperative queueing with different parameters and network configurations. We demonstrate that our algorithm is able to encourage cooperation and ensure fair sharing of bandwidth between nodes. We show that cooperative queueing is simple and has little overhead.
Agricultural conversion without external water and nutrient inputs reduces terrestrial vegetation productivity

Driven by global population and standard of living increases, humanity co‐opts a growing share of the planet's natural resources resulting in many well‐known environmental trade‐offs. In this study, we explored the impact of agriculture on a resource fundamental to life on Earth: terrestrial vegetation growth (net primary production; NPP). We demonstrate that agricultural conversion has reduced terrestrial NPP by ~7.0%. Increases in NPP due to agricultural conversion were observed only in areas receiving external inputs (i.e., irrigation and/or fertilization). NPP reductions were found for ~88% of agricultural lands, with the largest reductions observed in areas formerly occupied by tropical forests and savannas (~71% and ~66% reductions, respectively). Without policies that explicitly consider the impact of agricultural conversion on primary production, future demand‐driven increases in agricultural output will likely continue to drive net declines in global terrestrial productivity, with potential detrimental consequences for net ecosystem carbon storage and subsequent climate warming.
Characteristics of in situ oral biofilm after 2 and 4 days of evolution.

OBJECTIVE To analyze the evolution of the thickness, bacterial vitality, covering grade, and the structure after 2 and 4 days of aging in "non-disturbed" plaque-like biofilm (PL-biofilm). METHOD AND MATERIALS Twenty healthy volunteers wore a specific appliance. After 2 days half of the samples were removed from the appliance. Posteriorly, after bacterial vital staining, samples were analyzed using a confocal laser scanning microscope. In the first volunteer, one of the disks was analyzed using a scanning electronic microscope. The same process was realized on the remaining disks after 4 days. RESULTS The thicknesses of the PL-biofilm after 2 and 4 days were not significantly different. The bacterial vitality changed significantly from 72.50 ± 15.50% to 57.54 ± 15.66% over time, which was in contrast to the covering grade (53.08 ± 18.03% and 70.74 ± 19.11%). The structure changed from an irregular surface and compact deepest layer with a high predominance of the coccus shape to a complex structure with voids in the deepest layer and a great proportion of bacillus-shaped bacteria. CONCLUSION The PL-biofilm thickness remained practically constant, decreasing the bacterial vitality and increasing the covering grade over time. Regarding the structure, differences were principally bacterial disposition in the surface and bacterial shape. Clinically, the findings show that new control strategies for combating the oral biofilm should be focused on inhibiting bacterial adhesion to tooth surfaces, which would reduce biofilm formation.
Two‐coloring random hypergraphs

A 2‐coloring of a hypergraph is a mapping from its vertex set to a set of two colors such that no edge is monochromatic. Let H=H(k, n, p) be a random k‐uniform hypergraph on a vertex set V of cardinality n, where each k‐subset of V is an edge of H with probability p, independently of all other k‐subsets. Let \documentclass{article}\pagestyle{empty}\begin{document}$ m = p{{n}\choose{k}}$\end{document} denote the expected number of edges in H. Let us say that a sequence of events ℰn holds with high probability (w.h.p.) if limn→∞Pr[ℰn]=1. It is easy to show that if m=c2kn then w.h. p H is not 2‐colorable for c>ln 2/2. We prove that there exists a constant c>0 such that if m=(c2k/k)n, then w.h. p H is 2‐colorable. © 2002 Wiley Periodicals, Inc. Random Struct. Alg. 20: 249–259, 2002
Protein post‐translational modifications and misfolding: New concepts in heart failure

A new concept in the field of heart‐failure (HF) research points to a role of misfolded proteins, forming preamyloid oligomers (PAOs), in cardiac toxicity. This is largely based on few studies reporting the presence of PAOs, similar to those observed in neurodegenerative diseases, in experimental and human HF. As the majority of proteinopathies are sporadic in nature, protein post‐translational modifications (PTMs) likely play a major role in this growing class of diseases. In fact, PTMs are known regulators of protein folding and of the formation of amyloid species in well‐established proteinopathies. Proteomics has been instrumental in identifying both chemical and enzymatic PTMs, with a potential impact on protein mis‐/folding. Here we provide the basics on how proteins fold along with a few examples of PTMs known to modulate protein misfolding and aggregation, with particular focus on the heart. Due to its innovative content and the growing awareness of the toxicity of misfolded proteins, an “Alzheimer's theory of HF” is timely. Moreover, the continuous innovations in proteomic technologies will help pinpoint PTMs that could contribute to the process. This nuptial between biology and technology could greatly assist in identifying biomarkers with increased specificity as well as more effective therapies.