Miracle-dz/UniFAR-FTUs huggingface dataset:
Shading-Based Shape Refinement of RGB-D Images

We present a shading-based shape refinement algorithm which uses a noisy, incomplete depth map from Kinect to help resolve ambiguities in shape-from-shading. In our framework, the partial depth information is used to overcome bas-relief ambiguity in normals estimation, as well as to assist in recovering relative albedos, which are needed to reliably estimate the lighting environment and to separate shading from albedo. This refinement of surface normals using a noisy depth map leads to high-quality 3D surfaces. The effectiveness of our algorithm is demonstrated through several challenging real-world examples.
The effects of wear on abradable honeycomb labyrinth seals

This thesis reports on work undertaken to understand the effects, due to wear, on the performance of abradable honeycomb labyrinth seals. The phenomena studied are aerodynamic in nature and include compressible flow, turbulent flow, recirculation and separation at a range of pressure ratios from 1.20 up to 3.50. Four primary methods of investigation were used: experimental, numerical using CFD, numerical using theoretical derivations and numerical using established labyrinth seal specific computer codes. Effects of seal clearance, pressure ratio and tooth to groove location have been investigated with overall performance and inter-seal pressure distribution recorded experimentally and numerically for comparison. Worn experimental results, when compared to their unworn equivalent, recorded large increases in mass flow of up to 50% when the labyrinth teeth are located centrally in the groove. Significant performance enhancements were achieved through offsetting the teeth with respect to the groove, particularly in an upstream sense. There was a marked deterioration with the labyrinth teeth located at the groove exit. Inter-seal pressure distributions showed that the first and final teeth did most of the work achieving significantly larger pressure drops which goes against current seal understanding of increasing pressure drop through the seal. Numerical work was undertaken to further investigate these effects. However, due to the complex 3-D geometry of an abradable honeycomb labyrinth seal a 2-D simplification technique was developed to speed up the investigative process. Using this technique CFD was found capable of replicating the experimental data regarding overall seal performance and inter-seal pressure distributions. The pressure on the final tooth proved to be the hardest experimental data to recreate using CFD, particularly at high pressure ratios when shocks are likely to form. Further numerical work was undertaken using computer codes and theoretical derivations. This work proved that the understanding of the seal loss coefficients used by both methods was not adequate for the current study with the experimental data recreated least successfully. Suggestions are given for enhancement of seal design, including axial location and seal computational routines, which will limit the impact of a 1.5% increase in operational cost that is likely to accrue from seal deterioration.
Design space for driver-based automotive user interfaces

Over the last 100 years it has become much easier to operate a car. However in recent years the number of functions a user can control while driving has greatly increased. Infotainment, entertainment and comfort systems as well as driver assistance contribute to this trend. Interaction with these systems plays an important role, as on one hand this can improve the user experience while driving but on the other hand it may distract from the primary task of driving. User interfaces in cars differ regarding the number of input and output devices and their placement in the car to a great extent. In this paper, we introduce a first design space for driver-based automotive user interfaces that allows a comprehensive description of input and output devices in a car with regard to placement and modality. This design space is intended to provide a basis for analyzing and discussing different user interface arrangements in cars, to compare alternative user interface setups, and to identify new opportunities for interaction and placement of controls. We present a graphical representation of the design space and discuss its usage in detail based on several examples. To assess the completeness of the proposed design space we used it to classify and compare user interfaces from more than 100 cars shown at IAA2007, cars from the BMW museum, and from the A2Mac1 image database.
The highs and lows of theoretical interpretation in animal-metacognition research

Humans feel uncertain. They know when they do not know. These feelings and the responses to them ground the research literature on metacognition. It is a natural question whether animals share this cognitive capacity, and thus animal metacognition has become an influential research area within comparative psychology. Researchers have explored this question by testing many species using perception and memory paradigms. There is an emerging consensus that animals share functional parallels with humans’ conscious metacognition. Of course, this research area poses difficult issues of scientific inference. How firmly should we hold the line in insisting that animals’ performances are low-level and associative? How high should we set the bar for concluding that animals share metacognitive capacities with humans? This area offers a constructive case study for considering theoretical problems that often confront comparative psychologists. The authors present this case study and address diverse issues of scientific judgement and interpretation within comparative psychology.
Dynamic thermal management in 3D multicore architectures

Technology scaling has caused the feature sizes to shrink continuously, whereas interconnects, unlike transistors, have not followed the same trend. Designing 3D stack architectures is a recently proposed approach to overcome the power consumption and delay problems associated with the interconnects by reducing the length of the wires going across the chip. However, 3D integration introduces serious thermal challenges due to the high power density resulting from placing computational units on top of each other. In this work, we first investigate how the existing thermal management, power management and job scheduling policies affect the thermal behavior in 3D chips. We then propose a dynamic thermally-aware job scheduling technique for 3D systems to reduce the thermal problems at very low performance cost. Our approach can also be integrated with power management policies to reduce energy consumption while avoiding the thermal hot spots and large temperature variations.
Dietary Flexibility and Intestinal Plasticity in Birds: A Field and Laboratory Study

The adaptive modulation hypothesis posits that the expression of digestive proteins should be modulated in response to intake of their respective substrates. A corollary of this hypothesis suggests that dietary flexibility and digestive plasticity should be correlated. We examined these two hypotheses in two gra‐nivorous Chilean birds (Zonotrichia capensis and Diuca diuca) that differ in dietary breadth. D. diuca is a strict granivore, whereas Z. capensis also eats insects. In field‐caught birds, the activity of the intestinal dipeptidase aminopeptidase‐N was positively correlated with intake of insects in Z. capensis but not in D. diuca. This is the first field documentation of modulation of intestinal enzymes by diet in birds. Intestinal maltase and sucrase activities were not correlated with seed (vs. insect) intake in either species. In the laboratory, captive birds of both species exhibited similar modulation of membrane‐bound intestinal hydrolases when fed on synthetic diets of contrasting carbohydrate and protein composition. Maltase, sucrase, and aminopeptidase‐N activities were significantly higher in birds fed on the carbohydrate‐free than those on the carbohydrate‐containing diet. Activities of the three enzymes were positively correlated. Therefore, this increase probably resulted from nonspecific increases of all enzymes resulting from intake of the carbohydrate‐free diet. Principal components analysis separating the effect of diet on specific and on nonspecific modulation revealed that diet had a strong effect on nonspecific activity of intestinal enzymes in both Z. capensis and D. diuca. Diet also significantly affected aminopeptidase‐N activities when the effect of diet on nonspecific modulation was removed. Birds fed on the carbohydrate‐free, high‐protein diet had significantly higher specific aminopeptidase‐N activities than those fed on the carbohydrate‐containing diet. Our results cast doubts on the notion that dietary flexibility and the plasticity of the gut's enzymes are necessarily correlated and on the general validity of the adaptive modulation hypothesis.
Sample-Size Planning for More Accurate Statistical Power: A Method Adjusting Sample Effect Sizes for Publication Bias and Uncertainty

The sample size necessary to obtain a desired level of statistical power depends in part on the population value of the effect size, which is, by definition, unknown. A common approach to sample-size planning uses the sample effect size from a prior study as an estimate of the population value of the effect to be detected in the future study. Although this strategy is intuitively appealing, effect-size estimates, taken at face value, are typically not accurate estimates of the population effect size because of publication bias and uncertainty. We show that the use of this approach often results in underpowered studies, sometimes to an alarming degree. We present an alternative approach that adjusts sample effect sizes for bias and uncertainty, and we demonstrate its effectiveness for several experimental designs. Furthermore, we discuss an open-source R package, BUCSS, and user-friendly Web applications that we have made available to researchers so that they can easily implement our suggested methods.
Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms

SUMMARY Background: Aortic abdominal aneurysm (AAA) represents a common chronic degenerative disease of the aortic wall. Chronic inflammation and enzymatic degradation of elastic lamellae and extracellular matrix (ECM) proteins constitute the most prominent characteristics of AAAs. There is mounting evidence that matrix metalloproteinases (MMPs) are the predominant proteinases in the AAA wall. These enzymes represent a potential target for therapeutic intervention to modify vascular pathology. This paper is an overview of matrix metalloproteinases and their role in the pathophysiology, diagnosis and treatment of AAA. Literature search: Comprehensive search of the MEDLINE, EMBASE and HEAL-Link databases from 1980 to 2003. Findings: Increased levels of MMPs expression and activity have been demonstrated within the aortic wall of AAA, associating with histological alterations. An imbalance between MMPs and their inhibitors (Tissue Inhibitors of Matrix Metalloproteinases – TIMPs), may tip the equilibrium towards matrix degradation. MMPs as systemic biochemical markers of AAAs may contribute to diagnosis of unsuspected AAAs or to the surveillance of patients with small AAAs. Evidence of variations in MMPs, TIMPs and their mediator genes promoting the increased inheritance susceptibility of AAAs is less well documented. However, a broad spectrum of pharmaceutical agents (e.g. doxycycline, statins etc.) is known to inhibit MMP activity and attenuate medial destruction. Conclusion: Randomized clinical studies in patients in the early stages of AAA or in healthy individuals with great propensity to AAA development are required to demonstrate the causative relationship between MMPs and AAA. It still remains obscure whether long-term administration of MMP inhibitors can decelerate or even prevent the need for surgical repair.
Antenna Shape Synthesis Without Prior Specification of the Feedpoint Locations

An antenna shape synthesis method is proposed that allows shaping of the antenna geometry prior to specification of the feed location and type. This reduces the constraints placed on the optimization process and can lead to potentially new designs due to the increased degree of freedom afforded. An appropriate feedpoint is easily chosen after shape optimization by selecting a location on the resulting structure for best impedance matching. The procedure is made possible through the use of characteristic mode concepts. Examples show that the antenna-Q values of the resulting shaped radiators closely approach the fundamental bounds.
Relevance of Autoantibodies for the Classification and Pathogenesis of Neurological Diseases

In the last decade research on autoantibodies in neurological diseases of the central nervous system (CNS) has been very successful. An increasing number of autoantibodies and their target antigens have been detected, supporting stratification of patients and enabling specific treatment. The detection of autoantibodies depends on the assay used, as antibody binding requires the native conformation of the antigen. Although cumulative data is suggesting an important role of B cells and antibodies in Multiple Sclerosis (MS), numerous studies failed to identify specific biomarkers for MS (Figure 1). Even though several clinical, immunological and radiological studies tried to discover risk factors for disease progression, it remains an open issue to predict the individual disease course. However, recently autoantibodies have been discovered in some rare CNS demyelinating disease closely resembling MS (Table 1). Particularly Neuromyelitis Optica (NMO) gained enormous interest due to the discovery of autoantibodies targeting the water channel protein aquaporin-4 (AQP4) (Lennon et al., 2004; Lennon et al., 2005), which is expressed on astrocytic endfeet at the blood brain barrier (Nicchia et al., 2004) (Figure 1). This inflammatory demyelinating disease represents itself with optic neuritis and longitudinally extensive transverse myelitis (Wingerchuk et al., 1999) and was long considered as a severe variant of MS. Due to the detection and validation of this highly sensitive and specific biomarker, NMO is now regarded as a separate disease entity to MS. Consequently, the anti-AQP4 antibody serostatus was included into the diagnostic criteria of NMO (Jarius et al., 2007; Wingerchuk et al., 2007). Compared to MS, patients with NMO have a worse prognosis and require different treatment strategies according to the dominant humoral immunopathogenesis. With the advent of anti-AQP4 antibodies as biomarkers in NMO spectrum disorders (NMOSD), different NMO antibody assays have been developed, whereby cell based assays using the M23 isoform of AQP4 yield highest sensitivity (Takahashi et al., 2007; Waters & Vincent, 2008; Mader et al., 2010). Despite the high percentage of antiAQP4 IgG positive NMO patients, various studies described a lack of these autoantibodies in a cohort of NMO patients, which we will critically discuss in this chapter. It remains an open question whether these patients form their own subgroup of NMO patients or if the antibodies are not detected due to a sensitivity problem of the applied assays. Moreover, we will address
Effects of task-specific augmented feedback on deficit modification during performance of the tuck-jump exercise.

CONTEXT Anterior cruciate ligament (ACL) injuries are prevalent in female athletes. Specific factors have possible links to increasing a female athlete's chances of suffering an ACL injury. However, it is unclear if augmented feedback may be able to decrease possible risk factors. OBJECTIVE To compare the effects of task-specific feedback on a repeated tuck-jump maneuver. DESIGN Double-blind randomized controlled trial. SETTING Sports-medicine biodynamics center. PATIENTS 37 female subjects (14.7 ± 1.5 y, 160.9 ± 6.8 cm, 54.5 ± 7.2 kg). INTERVENTION All athletes received standard off-season training consisting of strength training, plyometrics, and conditioning. They were also videotaped during each session while running on a treadmill at a standardized speed (8 miles/h) and while performing a repeated tuck-jump maneuver for 10 s. The augmented feedback group (AF) received feedback on deficiencies present in a 10-s tuck jump, while the control group (CTRL) received feedback on 10-s treadmill running. MAIN OUTCOME MEASURES Outcome measurements of tuck-jump deficits were scored by a blinded rater to determine the effects of group (CTRL vs AF) and time (pre- vs posttesting) on changes in measured deficits. RESULTS A significant interaction of time by group was noted with the task-specific feedback training (P = .03). The AF group reduced deficits measured during the tuck-jump assessment by 23.6%, while the CTRL training reduced deficits by 10.6%. CONCLUSIONS The results of the current study indicate that task-specific feedback is effective for reducing biomechanical risk factors associated with ACL injury. The data also indicate that specific components of the tuck-jump assessment are potentially more modifiable than others.
The genome sequence of the facultative intracellular pathogen Brucella melitensis

Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortion in goats and sheep and Malta fever in humans. The genome of B. melitensis strain 16M was sequenced and found to contain 3,294,935 bp distributed over two circular chromosomes of 2,117,144 bp and 1,177,787 bp encoding 3,197 ORFs. By using the bioinformatics suite ERGO, 2,487 (78%) ORFs were assigned functions. The origins of replication of the two chromosomes are similar to those of other α-proteobacteria. Housekeeping genes, including those involved in DNA replication, transcription, translation, core metabolism, and cell wall biosynthesis, are distributed on both chromosomes. Type I, II, and III secretion systems are absent, but genes encoding sec-dependent, sec-independent, and flagella-specific type III, type IV, and type V secretion systems as well as adhesins, invasins, and hemolysins were identified. Several features of the B. melitensis genome are similar to those of the symbiotic Sinorhizobium meliloti.
Effects of L-thyroxine treatment on early markers of atherosclerotic disease in children with subclinical hypothyroidism.

OBJECTIVE To investigate the effect of levothyroxine (L-T4) treatment on early markers of atherosclerotic disease in children with mild idiopathic subclinical hypothyroidism (SH). DESIGN Two-year, open, case-control prospective study. METHODS A total of 39 children, aged 9.18±3.56 years, with SH and 39 healthy controls were enrolled in the study. Waist-to-height ratio (WHtR), blood pressure, triglycerides, total cholesterol (total-C), HDL-C, LDL-C, non-HDL-C, triglycerides/HDL-C, atherogenic index (AI), homocysteine (Hcy), asymmetric dimethylarginine (ADMA), flow-mediated dilation (FMD) and intima-media thickness (IMT) were evaluated at baseline and after 2 years of L-T4 treatment in SH children and after 2 years of follow-up in controls. RESULTS At study entry WHtR was higher in SH subjects compared with controls (0.56±0.08 vs 0.49±0.07, P=0.04) and significantly decreased after 2 years of treatment (0.50±0.06, P<0.0001). Mean HDL-C levels (50.47±11.43 vs 61.06±13.83mg/dL, P=0.002) were lower, while triglycerides/HDL-C (1.63±1.07 vs 1.19±0.69, P=0.05), AI (3.32±0.90 vs 2.78±0.68, P=0.005), and Hcy (9.35±2.61 vs 7.71±1.94μmol/L, P=0.01) were higher in SH subjects compared with controls and improved after 2 years of treatment (HDL-C 56.26±13.76mg/dL, P<0.0001; triglycerides/HDL-C 1.23±0.78, P=0.006; AI 2.82±0.68, P<0.0001; and Hcy 8.25±2.09μmol/L, P=0.06). ADMA concentrations at baseline were higher in SH subjects compared with controls (0.77±0.21 vs 0.60±0.16μmol/L, P=0.001) and decreased after therapy (0.58±0.13μmol/L, P<0.0001). FMD, IMT and other metabolic parameters were not different among SH subjects and controls at baseline and after 2 years. CONCLUSIONS Children with SH may have subtle pro-atherogenic abnormalities. Although L-T4 treatment exerts some beneficial effects, the long-term impact of therapy on metabolic outcomes in SH children still remains unclear.
Renal Interstitial Arteriosclerotic Lesions in Lupus Nephritis Patients: A Cohort Study from China

Objective The aim of this study was to evaluate renal arteriosclerotic lesions in patients with lupus nephritis and investigate their associations with clinical and pathological characteristics, especially cardio-vascular features. Design A retrospective cohort study. Participants Seventy-nine patients with renal biopsy-proven lupus nephritis, diagnosed between January 2000 and June 2008 from Peking University First Hospital. Results In clinico-pathological data, patients with arteriosclerosis had higher ratio of hypertension and more severe renal injury indices compared with patients with no renal vascular lesions. More importantly, patients with renal arteriosclerosis had worse cardiac structure and function under transthoracic echocardiographic examination. Patients with renal arteriosclerosis tend to have higher ratios of combined endpoints compared with those of no renal vascular lesions, although the difference didn’t reach statistical meanings (P = 0.104). Conclusion Renal arteriosclerotic lesion was common and associated with vascular immune complex deposits in lupus nephritis. It might have a certain degree of association with poor outcomes and cardiovascular events, which needs further explorations.
TATA Box Insertion Provides a Selection Mechanism Underpinning Adaptations to Fe Deficiency1[OPEN]

TATA-box insertion in the upstream untranslated sequences of genes enhances adaptation to selective pressure. Intraspecific genetic variation is essential for the responses and adaption of plants to evolutionary challenges, such as changing environmental conditions. The development of the Earth’s aerobic atmosphere has increased the demand for iron (Fe) in organisms, and Fe deficiency has become a limiting environmental factor for plant growth. Here, we demonstrate that genus Malus adapt to Fe deficiency through modification of the Iron-Regulated Transporter1 (IRT1) promoter. Specifically, an IRT1 mutant allele with a TATA-box insertion in the promoter region upstream of the coding region exhibited increased IRT1 expression. The altered IRT1 promoter is responsible for enhancing Fe uptake. Increasing the number of synthetic repeat TATA-boxes correlates with increased promoter activity. Furthermore, we demonstrate that the insertion of the TATA-box correlates with an increase in transcriptional activation via specific binding of the transcription factor IID (MDP0000939369). Taken together, these results indicate that an allelic insertion of a TATA-box in a gene promoter has allowed apple to adapt to the selective pressure posed by Fe deficiency. More broadly, this study reveals a new mechanism for enhancing gene expression to help plants adapt to different environments, providing new insights into molecular genetic divergence in plants.