Miracle-dz/UniFAR-FTUs huggingface dataset:
Long term results after surgical basal cell carcinoma excision in the eyelid region

AIMS To evaluate the data for patients with basal cell carcinoma (BCC) in the eyelid region, to demonstrate histologically controlled tumour excision, and to prove the efficacy of the treatment on the basis of long term observations. METHODS Retrospective analysis of 382 microscopically controlled BCC excisions in the eyelid apparatus (350 patients) in a follow up study over 5.7 (SD 1.1) years. Tumour location, tumour size, and histological results were recorded. The same procedure was followed for recurrences. Follow up examinations were carried out 1, 3, 6, and 12 months after the operation, and then annually for a further 4 years or longer. RESULTS A recurrence rate of 5.36% was observed after the primary operation. 60.3% of first recurrences occurred in the medial canthus, 41.2% showed in depth extension, and sclerosing types were overly represented at 35.3%. After the second operation the recurrence rate increased to 14.7% and reached 50% after a third and fourth operation. CONCLUSIONS The greatest risk of recurrence exists for BCCs of the medial canthus with in depth extension, and for sclerosing types. The recurrence rate increases after every operation. For high risk cases, consideration should be given to adjuvant treatment such as radiotherapy.
Ascorbic Acid in the Prevention and Treatment of Cancer

Proposed mechanisms of action for ascorbic acid (ascorbate, vitamin C) in the prevention and treatment of cancer include enhancement of the immune system, stimulation of collagen formation necessary for “walling off” tumors, inhibition of hyaluronidase which keeps the ground substance around the tumor intact and prevents metastasis, prevention of oncogenic viruses, correction of an ascorbate deficiency often seen in cancer patients, expedition of wound healing after cancer surgery, enhancement of the effect of certain chemotherapy drugs, reduction of the toxicity of other chemotherapeutic agents such as Adriamycin, prevention of free radical damage, and neutralization of carcinogenic substances. Scottish as well as Japanese studies have pointed to the potential benefit of high dose vitamin C for the treatment of “terminal” cancer. Mayo Clinic studies, however, have contradicted the Scottish and Japanese findings, resulting in accusations of methodological flaws from both sides. Numerous epidemiological studies have pointed to the importance of dietary and supplemental ascorbate in the prevention of various types of cancer including bladder, breast, cervical, colorectal, esophageal, lung, pancreatic, prostate, salivary gland, stomach, leukemia, and non-Hodgkin’s lymphoma. (Altern Med Rev 1998;3(3):174-186) Introduction In the mid-18th century, James Lind first demonstrated that the juice of fresh citrus cures scurvy. The active agent, the enolic form of 3-keto-L-gulofurnlactone, or ascorbic acid, was isolated in the late 1920s by Albert Szent-Gyorgyi (see figure 1). By the mid-1930s, methods had been devised to synthesize ascorbic acid, making it widely available at low cost. In the 1990s, it is the most commonly used single supplement in the U.S. In 1954, W.J. McCormick, a Canadian physician, formulated the hypothesis that cancer is a collagen disease, secondary to a vitamin C deficiency. While alternative cancer treatments, such as The Gerson therapy, have been incorporating diets high in vitamin C for many years, the use of vitamin C supplementation in large doses for the prevention and treatment of cancer was further advanced in 1971 by Linus Pauling, PhD, and Ewan Cameron, MD. A discussion of their use of high-dose vitamin C for treatment of patients with advanced cancer can be found below. Since 1971, considerable attention has been paid to vitamin C and cancer, particularly in Kathi Head, N.D. —Technical Advisor, Thorne Research, Inc.; Associate Editor, Alternative Medicine Review. Correspondence address: P.O. Box 25, Dover, ID 83825, e-mail: kathi@thorne.com
Choosing Collaboration Partners. How Scientific Success in Physics Depends on Network Positions

Physics is one of the most successful endeavors in science. Being a prototypic big science it also reflects the growing tendency for scientific collaborations. Utilizing 250,000 papers from ArXiv.org a prepublishing platform prevalent in Physics we construct large coauthorship networks to investigate how individual network positions influence scientific success. In this context, success is seen as getting a paper published in high impact journals of physical subdisciplines as compared to not getting it published at all or in rather peripheral journals only. To control the nested levels of authors and papers, and to consider the time elapsing between working paper and prominent journal publication we employ multilevel eventhistory models with various network measures as covariates. Our results show that the maintenance of even a moderate number of persistent ties is crucial for scientific success. Also, even with low volumes of social capital Physicists who occupy brokerage positions enhance their chances of articles in high impact journals significantly. Surprisingly, inter(sub)disciplinary collaborations decrease the probability of getting a paper published in specialized journals for almost all positions.
Positive impact by design: The Wales Centre for Behaviour Change

The Wales Centre for Behaviour Change is a research project that aims to integrate positive psychology with emerging technologies and behavioral science to promote prosperity and well-being. The behavioral focus emphasizes choice architectures and environmental triggers in their influence on positive change. This paper describes the background for this project, as well the theory and design of the center and its work. We review behavioral intervention technologies that the center is employing, or plans to employ, to augment the decision-making capabilities of its target audience. Technologies can be positioned in the behavioral stream to reduce complexity and distraction and in so doing help individuals make optimal decisions.
The Pretender

Following “reflexive ethnography” and using a “layered narrative” of autobiography, academic argument, exposition, and fictionalization set within the “story” of the author as “I” and a group of childhood friends on a summer night, this text challenges the apparent hegemony of mainstream academic writing of applied linguistics and poses alternative forms of writing. This theme is “performed” rather than “explained. ” Consequently, the text engages in what Denzin and Lincoln describe as the sixth moment of qualitative research, which calls for performative narratives blurring or eliminating the divisions between data and analysis through means of “creative writing” (e.g., scene, characterization). The following text, therefore, expounds on neither its theme, reflexive ethnographic approach, nor methodological positioning (above); rather, the text “dramatizes” its theme, approach, and methodology, with this present abstract signposting such intentions.1
Cohabitation and Marital Stability: Quality or Commitment.

The authors analyze the effects of cohabitation on couples perceived marital stability in the United States. "Using data from the 1987-88 National Survey of Families and Households we found that couples who cohabited before marriage reported lower quality marriages lower commitment to the institution of marriage more individualistic views of marriage (wives only) and greater likelihood of divorce than couples who did not cohabit. Effects were generally stronger for those who had cohabited for longer periods before marriage. Social and economic characteristics accounted for the higher perceived likelihood of divorce among those who had cohabited less than a year; differences in marital quality and institutional commitment accounted for remaining effects of longer cohabitation while marital individualism did not have significant effects on perceived likelihood of divorce. " This is a revised version of a paper originally presented at the 1990 Annual Meeting of the Population Association of America. (EXCERPT)
Comparing Spatial Planning Practice in Europe: A Plea for Cultural Sensitization

Abstract Comparative research into spatial planning systems typically adopts a structuralist/legalistic approach. This article presents and argues for an integrated perspective which embraces both systemic structures and concrete planning practices . The article begins with a short survey of the current state of comparative research on planning and its weaknesses. At the heart of the article is the endeavor to sensitize the discourse in planning theory towards a culturalistically oriented interpretational context. The studies which display the greatest potential for connectivity in this regard come from comparative research on governance. The concept of the institutional milieu which such research has produced provides the starting-point for an outline of some of the key aspects of a culturally sensitized form of comparative planning research which focuses primarily on the micro level. This represents something akin to a research agenda.
On the Eddington limit in accretion discs

Although the Eddington limit has originally been derived for stars, recently its relevance for the evolution of accretion discs has been realized. We discuss the question whether the classical Eddington limit – which has been applied globally for almost all calculations on accretion discs – is a good approximation if applied locally in the disc. For this purpose, a critical accretion rate corresponding to this type of modified classical Eddington limit is calculated from thin α-disc models and slim disc models. We account for the non-spherical symmetry of the disc models by computing the local upper limits on the accretion rate from vertical and radial force equilibria separately. It is shown that the results can differ considerably from the classical (global) value: The vertical radiation force limits the maximum accretion rate in the inner disc region to much less than the classical Eddington value in thin α-discs, while it allows for significantly higher accretion rates in slim discs. We discuss the implications of these results for the evolution of accretion discs and their central objects.
Morphodynamics of beach / dune systems: examples from the coast of France

Four representative sectors encapsulating the morphological and hydrodynamic diversity of the French coast are used to illustrate the morphodynamics of beach/dune systems at various timescales. These beach/dune systems cover the four shoreline sectors composing the French coast, i.e., the southern North Sea, the English Channel, the Atlantic Ocean, and the Mediterranean, and range from stormdominated short-fetch to swell settings, and from micro- to macrotidal. The short-term processes affecting the beach/dune systems are strongly hinged on wind incidence and storm intensity, while sediment supply, modulated by marine processes, notably storms and tides, and by the regional wind directions, constitutes the primary control on long-term patterns of development. Beach morphology, notably the presence of bar/berm-trough systems, and water levels attained during storms, constitute key elements in the process of sand supply to the dune systems, which vary from low, poorly developed forms in the Mediterranean, to the well developed, but largely presently stable to erosive systems characterising the other three sectors. The comparative study of these systems shows that there is no linear relationship between storm intensity and the rate of dune erosion (except on Vougot site, English Channel), because of the influence of various parameters, notably the antecedent beach state.
The Effects of Social Support, Depression, and Stress on Drinking Behaviors in a College Student Sample

Social support research contends that supportive interactions provide a buffer wherein individuals are protected from increased risk due to negative affect. The present study investigated the relationships between social support and college students' stress, depression, and alcohol use. A total of 54 students completed questionnaires in exchange for extra course credit. Results demonstrated that stress and depression were correlated with one another and that social support was negatively correlated with each of these outcomes. Depression, but not stress, was correlated with increased drinking behavior. Overall, social support was negatively correlated with alcohol consumption; however, depression moderated the effect of social support such that support and alcohol consumption were negatively correlated for participants with higher depression whereas support and alcohol consumption were positively correlated for individuals with lower depression. These findings partially confirm existing theories of alcohol use that hypothesize differences between self-medicating drinkers and social, sensation-seeking drinkers.
The Effect of Music on Atmosphere and Purchase Intentions in a Cafeteria

This exploratory study investigates the effect of music on the perceived characteristics of a commercial listening environment and on customers' purchase intentions therein. Three musical styles and also no music were played in a student cafeteria over the course of 4 days. Subjects' responses to a questionnaire indicated that different musical styles had different effects on the perceived characteristics of the cafeteria, and that classical music was associated with subjects being prepared to pay the most for food items on sale therein. There was also some indication that classical and pop music might have increased actual sales in the cafeteria, as compared with easy listening and silence. These results are discussed in terms of their implications for both commercial practice and our theoretical understanding of music and consumer behavior.
Host-plant genotypic diversity and community genetic interactions mediate aphid spatial distribution

Genetic variation in plants can influence the community structure of associated species, through both direct and indirect interactions. Herbivorous insects are known to feed on a restricted range of plants, and herbivore preference and performance can vary among host plants within a species due to genetically based traits of the plant (e.g., defensive compounds). In a natural system, we expect to find genetic variation within both plant and herbivore communities and we expect this variation to influence species interactions. Using a three-species plant-aphid model system, we investigated the effect of genetic diversity on genetic interactions among the community members. Our system involved a host plant (Hordeum vulgare) that was shared by an aphid (Sitobion avenae) and a hemi-parasitic plant (Rhinanthus minor). We showed that aphids cluster more tightly in a genetically diverse host-plant community than in a genetic monoculture, with host-plant genetic diversity explaining up to 24% of the variation in aphid distribution. This is driven by differing preferences of the aphids to the different plant genotypes and their resulting performance on these plants. Within the two host-plant diversity levels, aphid spatial distribution was influenced by an interaction among the aphid's own genotype, the genotype of a competing aphid, the origin of the parasitic plant population, and the host-plant genotype. Thus, the overall outcome involves both direct (i.e., host plant to aphid) and indirect (i.e., parasitic plant to aphid) interactions across all these species. These results show that a complex genetic environment influences the distribution of herbivores among host plants. Thus, in genetically diverse systems, interspecific genetic interactions between the host plant and herbivore can influence the population dynamics of the system and could also structure local communities. We suggest that direct and indirect genotypic interactions among species can influence community structure and processes.
Inhibition of porcine small intestinal sucrase by valienamine

Valienamine, an aminocyclitol, has been isolated from the enzymolysis broth of validamycins. The absolute configuration of valienamine is similar to that of α-d-glucose. The inhibitory effect of this amino-sugar analog of α-d-glucose, valienamine, on porcine small intestinal sucrase was examined. Valienamine was found to be potent, competitive reversible inhibitor of porcine small intestinal sucrase in vitro with an IC50 value of 1.17×10−3 M. Valienamine also exhibited dose-dependent, instantaneous inhibition of porcine small intestinal sucrase. The inhibition of porcine small intestinal sucrase by valienamine was pH-independent.
Change-driven model transformations - Change (in) the rule to rule the change

In the paper, we investigate change-driven model transformations, a novel class of transformations, which are directly triggered by complex model changes carried out by arbitrary transactions on the model (e.g. editing operation, transformation, etc). After a classification of relevant change scenarios, we identify challenges for change-driven transformations. As the main technical contribution of the current paper, we define an expressive, high-level language for specifying changedriven transformations as an extension of graph patterns and graph transformation rules. This language generalizes previous results on live model transformations by offering trigger events for arbitrarily complex model changes, and dedicated reactions for specific kinds of changes, making this way the concept of change to be a first-class citizen of the transformation language. We discuss how the underlying transformation engine needs to be adapted in order to use the same language uniformly for different change scenarios. The technicalities of our approach will be discussed on a (1) model synchronization case study with non-materialized target models and (2) a case study on detecting the violation of evolutionary (temporal) constraints in the security requirements engineering domain.
STUDENTS ANALYZING DATA : RESEARCH OF CRITICAL BARRIERS

In describing the work of the nineteenth-century statistician Quetelet, Porter (1986) suggested that his major contribution was in persuading some illustrious successors of the advantage that could be gained in certain cases by turning attention away from the concrete causes of individual phenomena and concentrating instead on the statistical information presented by the larger whole. This observation describes the essence of a statistical perspective−−attending to features of aggregates as opposed to features of individuals. In attending to where a collection of values is centered and how those values are distributed, statistics deals with features belonging not to any of the individual elements, but to the aggregate that they comprise. Although statistical assertions such as “50% of marriages in the U.S. result in divorce” or “the life expectancy of women born in the U.S. is 78.3 years” might be used to make individual forecasts, they are more typically interpreted as group tendencies or propensities. In this article, we raise the possibility that some of the difficulty people have in formulating and interpreting statistical arguments results from their not having adopted such a perspective, and that they make sense of statistics by interpreting them using more familiar, but inappropriate, comparison schemes.
"Am I Doing the Right Thing?": Pathways to Parenting a Gender Variant Child.

Gender variant (GV) children have a subjective sense of gender identity and/or preferences regarding clothing, activities, and/or playmates that are different from what is culturally normative for their biological sex. Despite increases in rates of GV children and their families presenting at clinics, there is little research on how raising a GV child affects the family as a whole or how families make decisions regarding their care. This study took an ecological-transactional framework to explore the question, "what is the experience of parents who raise a GV or transgender child? " Eight mothers and three fathers of GV male and female children (ages 5-13) referred through a GV support group participated in interviews. Transcripts were analyzed using an adaptation of grounded theory analysis. These parents attempted to pave the way to a nonstigmatized childhood for their GV child, typically through two pathways: rescuing the child from fear of stigma and hurt or accepting GV and advocating for a more tolerant world. Many participants used both pathways to different degrees or shifted paths over time, and the paths selected were related to parents' own understanding of GV and their experiences and backgrounds as well as characteristics of the children they were parenting and the communities they inhabited. Limitations, clinical implications, and future directions are discussed.
Intelligent power saving technique for mobile devices

Power saving in mobile devices has become a hot topic nowadays. Enhancing user experience through intelligent techniques that help to extend battery lifetime is today's goal for many manufacturers and developers. Different approaches to improve power consumption have focused on improving the hardware used, the operating system, and/or the applications performance; however, this study's focusisto design an intelligent software framework. After a throughout evaluation of the power consumption in different modules of the phone, in order to identify which modules consume power the most,a reinforcement learning method is proposed to effectively deal with this issue by granting/denying accessto the user of executing battery-draining tasks.
First-Time Parents’ and Grandparents’ Perceptions of Personal Growth: A Dyadic Approach

Drawing on the family systems theory and the theoretical concept of “linked lives,” this study examined personal growth among 340 Jewish Israeli pairs of parents and grandparents (680 participants) who had all recently (6–24 months earlier) undergone a major life transition: the birth of their first child or grandchild. The analysis examined the associations between personal growth and a series of other variables: self-esteem; perceived cognitive appraisals of threat, challenge, and self-efficacy; and perceived social support. In accordance with the theoretical approach, dyadic analyses based on the actor-partner interdependence model were used to assess the inter-relations between the two generations and their effect on the personal growth of each member of the dyad. The findings show that parents tend to perceive higher personal growth than grandparents, and that women tend to report higher growth than men. Furthermore, an individual’s experience of personal growth was associated not only with his or her own assessment of challenge, but with that of his or her parent or child as well. The results are discussed in respect to intergenerational perceptions and the potential mutual contributions to growth in both generations in the wake of these parallel life transitions.
CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

Using gene-expression data from over 6,000 breast cancer patients, we report herein that high CD73 expression is associated with a poor prognosis in triple-negative breast cancers (TNBC). Because anthracycline-based chemotherapy regimens are standard treatment for TNBC, we investigated the relationship between CD73 and anthracycline efficacy. In TNBC patients treated with anthracycline-only preoperative chemotherapy, high CD73 gene expression was significantly associated with a lower rate of pathological complete response or the disappearance of invasive tumor at surgery. Using mouse models of breast cancer, we demonstrated that CD73 overexpression in tumor cells conferred chemoresistance to doxorubicin, a commonly used anthracycline, by suppressing adaptive antitumor immune responses via activation of A2A adenosine receptors. Targeted blockade of CD73 enhanced doxorubicin-mediated antitumor immune responses and significantly prolonged the survival of mice with established metastatic breast cancer. Taken together, our data suggest that CD73 constitutes a therapeutic target in TNBC.