Miracle-dz/UniFAR-FTUs huggingface dataset:
Bone marrow drives central nervous system regeneration after radiation injury

Nervous system injury is a frequent result of cancer therapy involving cranial irradiation, leaving patients with marked memory and other neurobehavioral disabilities. Here, we report an unanticipated link between bone marrow and brain in the setting of radiation injury. Specifically, we demonstrate that bone marrow–derived monocytes and macrophages are essential for structural and functional repair mechanisms, including regeneration of cerebral white matter and improvement in neurocognitive function. Using a granulocyte-colony stimulating factor (G-CSF) receptor knockout mouse model in combination with bone marrow cell transplantation, MRI, and neurocognitive functional assessments, we demonstrate that bone marrow–derived G-CSF–responsive cells home to the injured brain and are critical for altering neural progenitor cells and brain repair. Additionally, compared with untreated animals, animals that received G-CSF following radiation injury exhibited enhanced functional brain repair. Together, these results demonstrate that, in addition to its known role in defense and debris removal, the hematopoietic system provides critical regenerative drive to the brain that can be modulated by clinically available agents.
VibrationCap: studying vibrotactile localization on the human head with an unobtrusive wearable tactile display

In this paper, we present the VibrationCap system and its evaluation. Two main contributions are made. First, we provide recommendations for wearable- and technology-design of head-worn vibration displays. Second, we study how accurately individual vibrations can be localized on the head, depending on their position. The VibrationCap is an unobtrusive, inconspicuous, wireless head-worn vibration display completely integrated into a regular beanie. We use 19 vibration motors to apply vibrations of varying duration to predefined locations of the head. Using this prototype, we conducted a study with 20 participants on the ability to locate vibrations applied to small areas (ca. 1 cm2) of the head. We show that depending on the region, the ability to locate vibration can vary significantly. With this data we created a vibro-tactile localization accuracy mapping of the human head.
Mixed-integer quadratic program trajectory generation for heterogeneous quadrotor teams

We present an algorithm for the generation of optimal trajectories for teams of heterogeneous quadrotors in three-dimensional environments with obstacles. We formulate the problem using mixed-integer quadratic programs (MIQPs) where the integer constraints are used to enforce collision avoidance. The method allows for different sizes, capabilities, and varying dynamic effects between different quadrotors. Experimental results illustrate the method applied to teams of up to four quadrotors ranging from 65 to 962 grams and 21 to 67 cm in width following trajectories in three-dimensional environments with obstacles with accelerations approaching 1g.
Process model patterns for collaborative work

As most real work is collaborative in nature, process model developers have to model collaborative situations. This paper defines generic collaborative patterns, ie, pragmatic and abstract building blocks for modelling recurrent situations. The first part specifies the graphical notation for the solution description. The second part gives some current patterns for the collaborative production of a single document in isolation and for the synchronization of two dependent documents. The conclusion emphasizes some implications for process-centered systems.
GLUT1 as a Prognostic Factor for Classical Hodgkin’s Lymphoma: Correlation with PD-L1 and PD-L2 Expression

Background Glucose transporter type 1 (GLUT1) expression is linked to glucose metabolism and tissue hypoxia. A recent study reported that GLUT1 was significantly associated with programmed death ligand 1 (PD-L1) as a therapeutic target in relapsed or refractory classical Hodgkin’s lymphoma (cHL). The purpose of this study was to measure the expression of GLUT1 and assess its prognostic significance and potential relationships with PD-L1, programmed death ligand 2 (PD-L2), and programmed death-1 (PD-1) expressions in cHL. Methods Diagnostic tissues from 125 patients with cHL treated with doxorubicin, bleomycin, vinblastine, and dacarbazine were evaluated retrospectively via immunohistochemical analysis of GLUT1, PD-L1, PD-L2, and PD-1 expression. Results The median follow-up time was 4.83 years (range, 0.08 to 17.33 years). GLUT1, PD-L1, PD-L2, and PD-1 were expressed in 44.8%, 63.2%, 9.6%, and 13.6% of the specimens, respectively. Positive correlations were found between GLUT1 and PD-L1 expression (p = .004) and between GLUT1 and PD-L2 expression (p = .031). GLUT1 expression in Hodgkin/Reed-Sternberg (HRS) cells was not associated with overall survival or event-free survival (EFS) in the entire cohort (p = .299 and p = .143, respectively). A subgroup analysis according to the Ann Arbor stage illustrated that GLUT1 expression in HRS cells was associated with better EFS in advanced-stage disease (p = .029). A multivariate analysis identified GLUT1 as a marginally significant prognostic factor for EFS (p = .068). Conclusions This study suggests that GLUT1 expression is associated with better clinical outcomes in advanced-stage cHL and is significantly associated with PD-L1 and PD-L2 expressions.
Evaluation of Four Commercial Immunoglobulin G (IgG)- and IgM-Specific Enzyme Immunoassays for Diagnosis of Mycoplasma pneumoniae Infections

ABSTRACT The four following commercially available enzyme immunoassays (EIAs) were assessed and compared for their performance in detecting Mycoplasma pneumoniae immunoglobulin G (IgG)- and IgM-specific antibodies Platelia EIA, ImmunoWELL M. pneumoniae ELISA IgG and IgM, ETI-MP-IgG and IgM EIAs and Biotest anti-M. pneumoniae IgG and IgM ELISA (referred to herein as EIA-Platelia, EIA-BMD, EIA-Sorin, and EIA-Biotest). Three groups of patients were investigated: 39 patients (27 children and 12 adults) with respiratory infections who tested positive by PCR for M. pneumoniae in respiratory specimens (group I; 52 serum samples), 61 healthy children and adults (group II; 61 serum samples), and 20 patients with rheumatoid factor or antinuclear antibodies, or who tested positive for antiviral IgM (group III; 20 serum samples). In group III, the IgM specificity for EIA-Platelia, EIA-BMD, EIA-Biotest, and EIA-Sorin was 100, 90, 65, and 25%, respectively. In the children from group I, the four EIAs had similar IgM sensitivities (89 to 92%); the sensitivity for IgG was greater with EIA-BMD and EIA-Biotest than with EIA-Platelia and EIA-Sorin (66 and 78% versus 55 and 52%, respectively). In adult patients from group I, 9 to 10 serum samples were positive for IgG with a concordant sensitivity of 75 to 83% between the four EIAs but a striking difference in IgM sensitivity: 16% by EIA-Platelia and EIA-BMD, 50% by EIA-Biotest, and 58% by EIA-Sorin. Discrepant and unexpected results were observed in IgM detection from control healthy patients using EIA-Sorin and EIA-Biotest, confirming the lack of specificity of these two EIAs and making them inaccurate for routine diagnosis. A good concordance of IgG seroprevalence in healthy adults was found between the four EIAs (66 to 70%), though this concordance was lower with EIA-Platelia (43%). In healthy children, EIA-BMD and EIA-Biotest gave a higher IgG seroprevalence than EIA-Sorin and EIA-Platelia (45% each for the former compared to 17 and 20%, respectively, for the latter). These results confirm that the IgM EIA serology test is a valuable tool for the early diagnosis of M. pneumoniae infections in children, as long as the EIA used is specific. In adults, the difficult interpretation of EIAs suggests that paired sera, combined with PCR detection on respiratory tract specimens collected on admission of patient, should be required for accurate diagnosis.
Usability and Feasibility of an mHealth Intervention for Monitoring and Managing Pain Symptoms in Sickle Cell Disease: The Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART)

Abstract Patients with sickle cell disease frequently experience severe pain events that lead to unplanned healthcare utilization. Mobile health tools (mHealth) may help prevent these events by providing remote monitoring and self-management support. This article describes the feasibility of the Sickle cell disease Mobile Application to Record symptoms via Technology (SMART), an mHealth app developed to help sickle cell disease patients monitor and manage their day-to-day symptoms. Fifteen patients recorded their pain intensity using a paper visual analog scale (VAS) and then repeated this measurement using an electronic VAS pain measure on SMART. Patients continued using SMART to record clinical symptoms, pain intensity, location and perceived severity, and treatment strategies for at least 28 days. Patient median age was 29 years (range 16–54); 60.0% were male. There was a high intraclass correlation between pain measurements entered on the paper VAS and SMART on the iPhone and the iPad We found a strong association between patient perceived pain severity and pain intensity entries using SMART (b = 1.71; p < 0.01). Daily compliance with SMART entries was a mean 75.0%, with a high of 85.7% in week 1 and low of 57.9% in week 4; however, one-third (n = 5) of the patients were 100.0% compliant even in week 4. Patients who were over age 35 or used an iPad for the study had the highest compliance rates. This study showed that SMART is a useable and feasible method for monitoring daily pain symptoms among adolescents and adults with sickle cell disease-related pain.
VEST: an aspect-based composition tool for real-time systems

Building distributed embedded systems from scratch is not cost-effective. Instead, designing and building these systems by using domain specific components has promise. However, in using components, the most difficult issues are ensuring that hidden dependencies won't cause failures and that non-functional properties such as real-time performance are being met. We have built the VEST toolkit whose aim is to provide a rich set of dependency checks based on the concept of aspects to support distributed embedded system development via components. We describe the toolkit and its novelty. We also use VEST on two case studies of a CORBA-based middleware for avionics. Data collected shows that VEST can significantly reduce the time it takes to build a distributed real-time embedded system by over 50%. Key "lessons learned" from our experience with using VEST on these case studies are also highlighted.
How Important is the Stock Market Effect on Consumption?

Many argue that the astonishing growth in Americans' stock portfolios in the 1990s has been a major force behind the growth of consumer spending. This article reviews the relationship between stock market movements and consumption. Using various econometric techniques and specifications, the authors find that the propensity to consume out of aggregate household wealth has exhibited instability over the postwar period. They also show that the dynamic response of consumption growth to an unexpected change in wealth is extremely short-lived, implying that forecasts of consumption growth one or more quarters ahead are not typically improved by accounting for changes in existing wealth. Finally, the impact effect of a wealth shock on consumption growth, while statistically positive, is found to be uncertain. Although recent market gains have provided support for consumer spending, the authors' findings are too limited to encourage reliance on estimates of the stock market effect in macroeconomic forecasts.
Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasis

Abstract Diphosphoinositol phosphates are a subclass of inositol phosphates possessing one or two high energy diphosphate groups instead of phosphoester substituents of the myo-inositol. Here we describe the enzymes responsible for their synthesis and degradation and how these may be regulated. Formation of diphosphoinositol phosphates in yeast and mammals is driven by an increase of the cellular energy charge, a lack of inorganic phosphate, and in mammals by osmotic or heat stress and in some cases by receptor mediated signaling. Known cellular actions are an improvement of the cell homeostasis by a reduction of the energy charge, increased phosphate uptake, improvement of mitochondrial performance, and an increase of insulin secretion in mammals. The underlying molecular mechanisms of action are far from being clarified but an increasing body of knowledge about molecular details has highlighted their complex participation in many cellular systems and metabolic processes.
Environmental Risk Assessment and Adaptive Management Implementation in Lake Simcoe, Ontario

Addressing the problems of low deep-water oxygen co ncentrations and impairment of cold-water fish habitats in Lake Simcoe as a case study of a d imictic mesotrophic lake requires reduction of external phosphorus (P) loading. However, the effic i n y of restoration efforts can be hindered by persistent internal P loading. This thesis devel ops a series of ecological and biogeochemical models, aiming at advancing our understanding of in ternal P recycling mechanisms in mesotrophic dimictic lakes. Special emphasis is giv en to sediment diagenesis processes and their interplay with the water column, macrophyte-mediate d P retention, and the nutrient nearshore shunt induced by dreissenids. First, a continuous B ayesian network is presented to investigate the cause-effect relationships among physical condition s, ambient nutrient concentrations, and plankton dynamics. P sediment internal loading is s ubsequently quantified with a reactivetransport simulation model of the transformation of P binding forms. Sediment dynamics are then assessed under conditions of varying organic m atter sedimentation and hypolimnetic oxygen levels. Finally, an integrated P mass-balance model is used to elucidate the internal P fluxes stemming from sediments, macrophytes and dreissenid . The model predicts that P diffusive fluxes from the sediments account for less than 3035% of the exogenous P loading in Lake Simcoe. In the post-dreissenid invasion era, the li mited decrease of the ice-free TP iii concentrations is indicative of the presence of act ive nutrient recycling pathways, potentially magnified by the particular morphological features and hydrodynamic patterns of Lake Simcoe, which counterbalance the direct effects of dreissen id filtration.
Effects of dezocine on prevention of propofol injection pain: a meta-analysis

Objective The objective of this study was to evaluate the effects of dezocine on the prevention of propofol injection pain. Materials and methods We searched for randomized controlled trials (RCTs) of dezocine in preventing propofol injection pain, from inception to April 2016, in PubMed, Embase, Cochrane Library, and CNKI. Next, two reviewers independently screened literature, extracted data, and assessed quality in accordance with the inclusion and exclusion criteria. Finally, RevMan 5.2 software was used to conduct a meta-analysis. Results Seven RCTs totaling 630 patients were included in this meta-analysis. The meta-analysis study showed: 1) compared with the control group (relative risk [RR] =0.32, 95% CI [0.26, 0.39], P<0.00001), the dezocine group showed a decreasing incidence of propofol injection pain; 2) for severity of propofol injection pain, incidences of mild pain (RR =0.55, 95% CI [0.40, 0.75], P=0.0001), moderate pain (RR =0.28, 95% CI [0.18, 0.43], P<0.00001), and severe pain (RR =0.11, 95% CI [0.06, 0.23], P<0.00001) were considerably lower in the dezocine group than in the control group; 3) when comparing the incidence of propofol injection pain in the dezocine group with that of the lidocaine group, no statistically significant differences were found (RR =0.86, 95% CI [0.66, 1.13], P=0.29); and 4) subgroup analysis indicated a significant reduction in the incidence of propofol injection. Conclusion Dezocine can both prevent propofol injection pain and mitigate its severity, and its efficacy shows no significant difference from that of lidocaine.
Structural congenital defects in multiple births.

The prevalence of twinning and higher order multiple births is high and is increasing in many countries, due at least in part to fertility-enhancing medical therapies. About 1 in 40-45 births is a twin; it is thus important to investigate whether the twinning status confers a higher risk for morbidity and mortality, particularly early in life. Birth defects are a major cause of morbidity and mortality in the pediatric age-group. The purpose of this review is to consider the evidence for an increased risk of some birth defects associated with twinning, using data from the literature and the Italian Multicentre Birth Defects Registry (IPIMC), to illustrate some of the challenging aspects of the study of birth defects in twins, and to suggest some guidelines for future investigations.
Modal Analysis Comparison of Beam and Shell Models for Composite Blades

The composite blades of wind turbines are made up of composite shell components. However, blades are often simplified as Eulerian beam in finite element analysis. In design both special and general purpose finite element codes are used worldwide. The verification of a special finite element code BModes vs. a popular general purpose finite element code ANSYS are performed via a uniform blade in both still and spinning cases in this paper. The test reveals that general finite element codes like ANSYS might overestimate the lag frequencies in spinning case. After verification of beam model, the approach is applied to complete the modal analysis of a practical wind turbine blade. The results are compared with a known shell model from literature. The comparison validates the simplified Eulerian beam model. Finally a guideline of usage for these two models is given.
HUME: Human UCCA-Based Evaluation of Machine Translation

Human evaluation of machine translation normally uses sentence-level measures such as relative ranking or adequacy scales. However, these provide no insight into possible errors, and do not scale well with sentence length. We argue for a semantics-based evaluation, which captures what meaning components are retained in the MT output, thus providing a more fine-grained analysis of translation quality, and enabling the construction and tuning of semantics-based MT. We present a novel human semantic evaluation measure, Human UCCA-based MT Evaluation (HUME), building on the UCCA semantic representation scheme. HUME covers a wider range of semantic phenomena than previous methods and does not rely on semantic annotation of the potentially garbled MT output. We experiment with four language pairs, demonstrating HUME's broad applicability, and report good inter-annotator agreement rates and correlation with human adequacy scores.
Spoken Language Understanding in dialogue systems, using a 2-layer Markov Logic Network: improving semantic accuracy

We describe a two layer Markov Logic Network (MLN) model for the Spoken Language Understanding (SLU) task in dialogue systems. We augment the set of features used in Meza-Ruiz et al. (2008) with the help of off-the-shelf resources. We show that this setup increases the performance of the previous MLN models, which also outperform the state-of-the art “Hidden Vector State” (HVS) model of He and Young 2006. In particular the 2 layer approach produces more accurate sets of slot-values for user utterances (9% improvement).
Tax Compliance as the Result of a Psychological Tax Contract: The Role of Incentives and Responsive Regulation

A psychological tax contract goes beyond the traditional deterrence model and explains tax morale as a complicated interaction between taxpayers and the government. As a contractual relationship implies duties and rights for each contract party, tax compliance is increased by sticking to the fiscal exchange paradigm between citizens and the state. Citizens are willing to honestly declare income even if they do not receive a full public good equivalent to tax payments as long as the political process is perceived to be fair and legitimate. Moreover, friendly treatment of taxpayers by the tax office in auditing processes increases tax compliance.
Histology and Histopathology Muscle regeneration induced by snake venom . A histological and histochemical study

This report describes the regeneration pattern of anterior tibial muscle of the rat after the inoculation of the snake venom of Bothrops jararacussu . The results show that this regeneration pattern is rather similar to the pattern described in other experimental models. Three days after the injection, three differentiated areas are established: a periferic one of surviving fibres, a second one called myogenic area, and the last one, more internal, made of necrotic fibres that are phagocited by macrophages. The surface of the surviving muscle fibres has myoblasts sticking to it and five days after, the myogenic area is occupied by many of them. Both the previous phagocytosis and the myoblasts came from the area of current uninjured fibres. After 30 and 60 days the regeneration is completed and there are only a few marks that show that the regeneration has taken place.
Can We Predict the Generation of Bugs ? Software Architecture and Quality in Open-Source Development

We study how software architecture relates to quality. Based on a software architecture representation that accounts for not only the hierarchical arrangement of its subsystems and components but also their dependency structure, we formally define the notion of system cyclicality. System cyclicality is an architectural property that captures the fraction of mutually interdependent components in a system. By examining multiple versions of 20 open-source, java-based applications (126 total) developed by the Apache Foundation, we empirically analyze the relationship between software architecture characteristics and the creation of bugs. Our results suggest that, while controlling for various system characteristics, system cyclicality is a key determinant of bug creation. Interestingly, we found evidence that it is not just the cycles themselves, but how hidden they are, that drive the effects of system cyclicality and bug creation. From an academic viewpoint, this work provides a theoretical and empirical basis for a causal link between the architecture of a complex system and its quality. This has important implications for the management of complex system design and development in fast-paced industries such as software. Our results suggest that managers could benefit from proactively examining the architecture of the system they develop and monitoring its cyclicality as one of their strategies to mitigate the creation of defects. DRAFT – Please, do not quote or distribute without permission 1
Diffusion tensor imaging on white matter in normal adults and elderly patients with hypertension.

散开加权的磁性的回声成像(MRI ) 利用随机面对磁场坡度移动水分子的性质。 在织物以内，水分子的散开被房间膜限制，小容器，轴突柱体，膜，水和大分子的化学相互作用。 在大脑，沿着白物质的长轴在取向浇散开 exhibitsdirectionality。 这被叫作“散开 anisotropy ”。 散开 anisotropy 能经由散开张肌成像(DTI ) 被测量。 有反映与在织物的每 voxel 以内的建筑上、结构的连贯的度有关的水散开的 anisotropy 的度的 anisotropy 索引的一个班。 部分 anisotropy (FA ) 是 anisotropy 的最经常使用的索引。 这研究是探索是否，并且检验散开性质是否被改变在正常的显得白性别，散开的年龄差别在正常成年人的白物质存在有高血压的老病人的物质(NAWM ) 。