Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolic Syndrome and Hypertension Resulting from Fructose Enriched Diet in Wistar Rats

Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-old male rats were randomly divided into 2 groups: control (C; n = 14) and fructose fed (FF; n = 18), with a fructose enriched drink (20–25% w/v fructose in water) for 21 weeks. Systolic blood pressure, fasting glycemia, and bodyweight were regularly measured. Glucose tolerance was evaluated three times using an oral glucose tolerance test. Insulin levels were measured concomitantly and insulin resistance markers were evaluated (HOMA 2-IR, Insulin Sensitivity Index for glycemia (ISI-gly)). Lipids profile was evaluated on plasma. This fructose supplementation resulted in the early induction of hypertension without renal failure (stable theoretical creatinine clearance) and in the progressive development of fasting hyperglycemia and insulin resistance (higher HOMA 2-IR, lower ISI-gly) without modification of glucose tolerance. FF rats presented dyslipidemia (higher plasma triglycerides) and early sign of liver malfunction (higher liver weight). Although abdominal fat weight was increased in FF rats, no significant overweight was found. In Wistar rats, 21 weeks of fructose supplementation induced a metabolic syndrome (hypertension, insulin resistance, and dyslipidemia) but not T2D.
How anthropomorphism affects empathy toward robots

A long-standing question within the robotics community is about the degree of human-likeness robots ought to have when interacting with humans. We explore an unexamined aspect of this problem: how people empathize with robots along the anthropomorphic spectrum. We conducted an experiment that measured how people empathized with robots shown to be experiencing mistreatment by humans. Our results indicate that people empathize more strongly with more human-looking robots and less with mechanical-looking robots.
Effects of tolvaptan on dyspnoea relief from the EVEREST trials.

AIMS To describe the effects of tolvaptan therapy on dyspnoea relief based on timing of delivery, influence of concomitant therapies, and baseline patient and clinical characteristics. Also, the influence of clinical trial design on dyspnoea measurement, from the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) trials. METHODS AND RESULTS Post hoc analysis was performed based on the endpoint of patient-assessed dyspnoea. Changes from baseline at inpatient Day 1 were compared between treatment groups by the van Elteren test. Pre-determined subgroup analyses were also performed. Tolvaptan's effects are greatest within 12 h after first dose with an additional, but modest dyspnoea improvement benefit irrespective of time after admission. Overall, patients continue to report dyspnoea improvement up to 60 h after admission. The window of enrolment, up to 48 h after admission, combined with measurement on 'Day 1' led to a wide range over when dyspnoea was assessed. CONCLUSION Post hoc analysis suggests that tolvaptan modestly improves dyspnoea compared with standard therapy alone, regardless if given early or relatively late after hospitalization, and also across major pre-specified subgroups, despite ongoing background therapy aimed at relieving signs and symptoms. Significant variability around when dyspnoea was assessed, in addition to the persistence of dyspnoea despite ongoing background therapy, may influence how future clinical trials assess dyspnoea in acute heart failure syndromes.
Short time window for transmissibility of African swine fever virus from a contaminated environment

Since the introduction of African swine fever virus (ASFV) into the Baltic states and Poland in 2014, the disease has continued to spread within these regions. In 2017, the virus spread further west and the first cases of disease were reported in the Czech Republic and Romania, in wild boar and domestic pigs, respectively. To control further spread, knowledge of different modes of transmission, including indirect transmission via a contaminated environment, is crucial. Up until now, such an indirect mode of transmission has not been demonstrated. In this study, transmission via an environment contaminated with excretions from ASFV-infected pigs was investigated. Following euthanasia of pigs that were infected with an isolate of ASFV from Poland (POL/2015/Podlaskie/Lindholm), healthy pigs were introduced into the pens, in which the ASFV-infected pigs had been housed. Introduction was performed at 1, 3, 5 or 7 days, following euthanasia of the infected pig groups. Pigs, that were introduced into the contaminated environment after 1 day, developed clinical disease within 1 week, and both ASFV DNA and infectious virus were isolated from their blood. However, pigs introduced into the contaminated pens after 3, 5 or 7 days did not develop any signs of ASFV infection and no viral DNA was detected in blood samples obtained from these pigs within the following 3 weeks. Thus, it was shown that exposure of pigs to an environment contaminated with ASFV can result in infection. However, the time window for transmissibility of ASFV seems very limited, and, within our experimental system, there appears to be a rapid decrease in the infectivity of ASFV in the environment.
Effect of the Addition of Molybdenum on the Structure and Corrosion Resistance of Zinc–Iron Plating

Zn–Ni plating is indispensable in various industries because of its high corrosion resistance. However, Ni has been reported to trigger allergies; thus, an alternative Ni-free plating is desired. Zn–Fe plating is considered to be a promising candidate, albeit its corrosion resistance still needs to be improved. The corrosion resistance of Zn–Fe plating is expected to increase by the addition of Mo as the third alloying element as it is more noble than Zn and Fe. In this study, Zn–Fe–Mo plating with a corrosion resistance nearly equivalent to that of the Zn–Ni plating was fabricated. Zn–Fe–Mo plating was electrically deposited from continuously-agitated plating baths prepared by mixing ZnSO4, FeSO4, Na2MoO4, Na3C6H5O7, and Na2SO4 using Fe or Ni plates as the substrate. The surface morphology, composition, crystal phase, and electronic state of Mo of the platings were investigated by scanning electron microscopy equipped with energy-dispersive spectroscopy (SEM-EDS), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The anti-corrosion performance was evaluated by Tafel extrapolation method. Formation of plating comprising a Mo containing alloy phase was found to be crucial for improving corrosion resistance. The Zn–Fe–Mo plating demonstrates promise for replacing anti-corrosion Zn–Ni platings.
Raman spectroscopy of cementitious materials

Recent advances in Raman spectrometers, resulting in faster acquisition times and the use of lower powered lasers have led to a resurgence in the application of Raman spectroscopy to the study of cementitious materials. However, despite it being widely believed that we know all about these materials, modern cements are extremely complex, heterogeneous materials. Given their complexity, and the widespread application of cement and concrete in today’s society, modern research into cement and concrete is truly multidisciplinary, with experts from the fields of chemistry, geology, mineralogy, materials science, corrosion science, engineering, even biology and medical science all investigating the structure and behaviour of cementitious materials. This review aims to look at the development of Raman spectroscopy as applied to the field of cement science. Starting with a historical overview, it then considers the spectra of cements at different stages in their lives, from fresh anhydrous materials, to hydrating and hydrated pastes, through to their degraded state. Whilst being concerned primarily with Portland cements, some alternative cementitious materials are also discussed, as are some of the additional materials found in modern cements and concretes; such as admixtures, cement replacement materials and reinforcement steel. However, it is not concerned with aggregates added to concrete, since this would be huge undertaking and would detract from the true focus of the review. Finally, the article identifies gaps in our current understanding and offers suggestions for potential future developments in the field.
Data Augmentation for deep neural network acoustic modeling

Data augmentation using label preserving transformations has been shown to be effective for neural network training to make invariant predictions. In this paper we focus on data augmentation approaches to acoustic modeling using deep neural networks (DNNs) for automatic speech recognition (ASR). We first investigate a modified version of a previously studied approach using vocal tract length perturbation (VTLP) and then propose a novel data augmentation approach based on stochastic feature mapping (SFM) in a speaker adaptive feature space. Experiments were conducted on Bengali and Assamese limited language packs (LLPs) from the IARPA Babel program. Improved recognition performance has been observed after both cross-entropy (CE) and state-level minimum Bayes risk (sMBR) training of DNN models.
Rheology of highly filled natural CaCO3 composites. II. Effects of solid loading and particle size distribution on rotational rheometry

Suspensions of poly(dimethyl siloxane) containing various loadings of natural CaCO3 particles, of several particle size distributions, were studied using capillary rheometry. Highly loaded suspensions were characterized, emphasizing their unique rheological behavior. Shear thinning was observed mainly for suspensions with solid loading close to the maximal volume fraction, significant at low frequency and becoming negligible at 1 decade higher frequency. The Cox-Merz rule was found valid for suspensions containing up to nearly 40 vol% particles. The viscosity was unaffected by particle size up to roughly 40 vol% particles as well. However, the dominancy of particle size distribution was demonstrated by the relative viscosity; fine filler suspensions exhibited much higher viscosity at a given loading. Equivalently, the maximal solid loading of coarse unimodal and of bimodal particle size distributions was significantly higher than the one of fine unimodal suspensions. Fair agreement with the Chong and Krieger-Dougherty (k = 2.5) models was found for unimodal suspensions, while the combined Farris-Chong model showed a much better fit for the bimodal suspensions. A unique behavior of the high volume fraction suspensions is the liquid solid transition that is defined by the crossover of G′ and G″ as function of frequency curves. Nevertheless, tan δ as a function of frequency curves for all studied compositions showed positive slopes, which is characteristic of solid-like materials. POLYM. COMPOS. , 28:524–533, 2007. © 2007 Society of Plastics Engineers
Helping coaches apply the principles of representative learning design: validation of a tennis specific practice assessment tool

ABSTRACT Representative Learning Design (RLD) is a framework for assessing the degree to which experimental or practice tasks simulate key aspects of specific performance environments (i.e. competition). The key premise being that when practice replicates the performance environment, skills are more likely to transfer. In applied situations, however, there is currently no simple or quick method for coaches to assess the key concepts of RLD (e.g. during on-court tasks). The aim of this study was to develop a tool for coaches to efficiently assess practice task design in tennis. A consensus-based tool was developed using a 4-round Delphi process with 10 academic and 13 tennis-coaching experts. Expert consensus was reached for the inclusion of seven items, each consisting of two sub-questions related to (i) the task goal and (ii) the relevance of the task to competition performance. The Representative Practice Assessment Tool (RPAT) is proposed for use in assessing and enhancing practice task designs in tennis to increase the functional coupling between information and movement, and to maximise the potential for skill transfer to competition contexts.
Harnessing the immune system in the battle against breast cancer

Breast cancer is the most prevalent malignancy in women and the second most common cause of cancer-related death worldwide. Despite major innovations in early detection and advanced therapeutics, up to 30% of women with node-negative breast cancer and 70% of women with node-positive breast cancer will develop recurrence. The recognition that breast tumors are infiltrated by a complex array of immune cells that influence their development, progression, and metastasis, as well as their responsiveness to systemic therapies has sparked major interest in the development of immunotherapies. In fact, not only the native host immune system can be altered to promote potent antitumor response, but also its components can be manipulated to generate effective therapeutic strategies. We present here a review of the major approaches to immunotherapy in breast cancers, both successes and failures, as well as new therapies on the horizon.
Alternative Saccharomyces interspecies hybrid combinations and their potential for low‐temperature wort fermentation

The lager yeast hybrid (Saccharomyces cerevisiae × Saccharomyces eubayanus) possesses two key characteristics that are essential for lager brewing: efficient sugar utilization and cold tolerance. Here we explore the possibility that the lager yeast phenotype can be recreated by hybridizing S. cerevisiae ale yeast with a number of cold‐tolerant Saccharomyces species including Saccharomyces arboricola, Saccharomyces eubayanus, Saccharomyces mikatae and Saccharomyces uvarum. Interspecies hybrids performed better than parental strains in lager brewing conditions (12°C and 12°P wort), with the S. mikatae hybrid performing as well as the S. eubayanus hybrid. Where the S. cerevisiae parent was capable of utilizing maltotriose, this trait was inherited by the hybrids. A greater production of higher alcohols and esters by the hybrids resulted in the production of more aromatic beers relative to the parents. Strong fermentation performance relative to the parents was dependent on ploidy, with polyploid hybrids (3n, 4n) performing better than diploid hybrids. All hybrids produced 4‐vinyl guaiacol, a smoke/clove aroma generally considered an off flavour in lager beer. This characteristic could however be eliminated by isolating spore clones from a fertile hybrid of S. cerevisiae and S. mikatae. The results suggest that S. eubayanus is dispensable when constructing yeast hybrids that express the typical lager yeast phenotype. © 2017 The Authors. Yeast published by John Wiley & Sons, Ltd.
Use of FDG PET/CT in identification of bone marrow involvement in diffuse large B cell lymphoma and follicular lymphoma: comparison with iliac crest bone marrow biopsy

Background Non-Hodgkin’s lymphoma (NHL) accounts for around 4% of new cancer cases annually. Bone marrow involvement is important for staging and management. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is used increasingly to identify this, in addition to bone marrow biopsy (BMB), which is seen as “gold” reference standard. Purpose To compare determination of bone marrow involvement by FDG PET/CT against BMB in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). Material and Methods This was a retrospective study of patients with histologically confirmed NHL at a single UK cancer center undergoing pre-treatment FDG PET/CT and BMB between June 2010 and February 2013. Information was collected from patient notes, cancer registry, histological and imaging reports. Diagnostic accuracy of FDG PET/CT was determined, compared to BMB as the reference standard. Results Twenty-four patients with DLBCL and 12 with FL were included. Five DLBCL patients had bone marrow involvement on PET/CT; all were confirmed on BMB. Three FL patients had marrow involvement on PET/CT but not on BMB; one FL patient had positive BMB but negative PET/CT. Using BMB as the reference standard, the sensitivity and specificity of FDG PET/CT for detecting bone marrow involvement in DLBCL were 100% and 100%, respectively, and in FL were 0% and 72.7%, respectively. Conclusion FDG PET/CT is accurate for detection of bone marrow involvement in newly diagnosed DLBCL, but not FL. In DLBCL, positive FDG PET/CT may negate the need for routine BMB, although BMB in addition or combination may be appropriate if this would influence management or prognosis.
Predictors of hospital admission for chronic obstructive pulmonary disease exacerbations in Canadian emergency departments.

OBJECTIVES The objective was to examine predictors of hospital admission among adults presenting to Canadian emergency departments (EDs) for acute exacerbations of chronic obstructive pulmonary disease (COPD). Current acute treatment approaches and outcomes 2 weeks after the ED visit are also described. METHODS Subjects, aged > or =35 years presenting with COPD exacerbations to 16 EDs across Canada, underwent a structured in-ED interview and a telephone interview 2 weeks later. RESULTS Of 501 study patients, 247 (49.3%; 95% confidence interval [CI] = 44.9% to 53.6%) were admitted. Admitted patients were older, were more often former smokers, and had more admissions for COPD during the past 2 years. They also reported more days of activity limitation and use of inhaled beta(2)-agonists in the previous 24 hours. Canadian Triage and Acuity Scale (CTAS), respiratory rate (RR), and airflow obstruction were more severe in the hospitalized group. Most of the patients received inhaled beta(2)-agonists, anticholinergics, oral corticosteroids (CS), and antibiotics; hospitalized patients received more aggressive treatments. The median ED length of stay (LOS) of admitted patients was 13.1 hours (interquartile range [IQR] = 7.4-23.0) compared to 5.6 hours (IQR = 4.2-8.4) in discharged patients. Admission was associated with at least two COPD admissions in the past 2 years (odds ratio [OR] = 2.10; 95% CI = 1.24 to 3.56), receiving oral CS for COPD (OR = 1.72; 95% CI = 1.08 to 2.74), having a CTAS score of 1-2 (OR = 2.04; 95% CI = 1.33 to 3.12), and receiving adjunct ED treatments (OR = 3.95; 95% CI = 2.45 to 6.35). Use of EDs for usual COPD care was associated with a reduced risk of admission (OR = 0.43; 95% CI = 0.28 to 0.66). CONCLUSIONS Exacerbations of COPD in Canadian EDs result in prolonged ED stays and approximately 50% hospitalization despite aggressive acute treatment approaches. Historical, severity, and treatment-related factors were strongly associated with hospital admission. Validation of these results should be completed prior to widespread use.
Effect of leptin on polymorphonuclear leucocyte functions in healthy subjects and haemodialysis patients.

BACKGROUND Dysfunction of polymorphonuclear leucocytes (PMNLs) in end-stage renal disease (ESRD) patients contributes to a diminished immune defence. The serum levels of leptin are elevated in patients with ESRD. We analysed in vitro effects of leptin on PMNLs from healthy subjects (HS; n = 12) and haemodialysis (HD) patients (n = 15) before and after HD. METHODS PMNL oxidative burst and phagocytosis were tested by flow cytometry in whole blood. Chemotaxis of isolated PMNLs was assessed by the under-agarose method. To assess the involvement of leptin in PMNL signalling pathways, signal transduction inhibitors were used and the activity of intracellular kinases was investigated by western blotting, in vitro kinase assays and the Luminex technology. RESULTS Increasing the leptin level in the blood of HS leads to a reduced activation of the oxidative burst by Escherichia coli and phorbol 12-myristate 13-acetate. Activation of the oxidative burst is reduced in the blood of HD patients and the addition of leptin does not lead to further PMNL inhibition. Leptin at a concentration measured in HD patients significantly reduces the chemotaxis of PMNLs from HS but had no effect on PMNLs from ESRD patients before and also after HD treatment with high-flux dialysers. The phosphoinositide 3-kinase/Akt pathway is involved in the inhibitory effects of leptin. CONCLUSIONS In the presence of leptin, PMNLs from HS and HD patients respond differently to stimuli. The lack of response to leptin in PMNLs from HD patients cannot be influenced by HD.
YALE: rapid prototyping for complex data mining tasks

KDD is a complex and demanding task. While a large number of methods has been established for numerous problems, many challenges remain to be solved. New tasks emerge requiring the development of new methods or processing schemes. Like in software development, the development of such solutions demands for careful analysis, specification, implementation, and testing. Rapid prototyping is an approach which allows crucial design decisions as early as possible. A rapid prototyping system should support maximal re-use and innovative combinations of existing methods, as well as simple and quick integration of new ones.This paper describes Yale, a free open-source environment forKDD and machine learning. Yale provides a rich variety of methods whichallows rapid prototyping for new applications and makes costlyre-implementations unnecessary. Additionally, Yale offers extensive functionality for process evaluation and optimization which is a crucial property for any KDD rapid prototyping tool. Following the paradigm of visual programming eases the design of processing schemes. While the graphical user interface supports interactive design, the underlying XML representation enables automated applications after the prototyping phase.After a discussion of the key concepts of Yale, we illustrate the advantages of rapid prototyping for KDD on case studies ranging from data pre-processing to result visualization. These case studies cover tasks like feature engineering, text mining, data stream mining and tracking drifting concepts, ensemble methods and distributed data mining. This variety of applications is also reflected in a broad user base, we counted more than 40,000 downloads during the last twelve months.