Miracle-dz/UniFAR-FTUs huggingface dataset:
Positive effects, side effects, and adverse events of clinical holistic medicine. A review of Gerda Boyesen's nonpharmaceutical mind-body medicine (biodynamic body-psychotherapy) at two centers in the United Kingdom and Germany.

UNLABELLED To review adverse events of intensive, clinical holistic medicine (CHM) as it is practiced in holistic body-psychotherapy in England and Germany. Gerda Boyesen's "biodynamic body-psychotherapy" (BBP) is an intensive type of holistic mind-body medicine used by Boyesen at two centers. METHODS About 13,500 patients were treated during 1985-2005 period and studied for side effects and adverse events. The first author worked closely with Boyesen 1995-2005 with full insight in all aspects of the therapy and provided the data on side-effects. RESULTS Therapy helped chronic patients with physical, psychological, sexual, psychiatric and existential problems to improve health, ability, and quality of life (NNT (number needed to treat) = 1-3). Effective in the treatment of mentally ill patients (schizophrenia, anxiety, poor mental health, low general ability). For retraumatization, brief reactive psychosis, depression, depersonalization and derealization, implanted memories, side effects from manipulations of the body, suicide/suicide attempts, hospitalization for physical and mental health problem during or 90 days after treatment, NNH (number needed to harm) > 13,500. INTERPRETATION Intensive, holistic non-drug medicine is helpful for physical, sexual, psychological, psychiatric and existential problems and is completely safe for the patient. The therapeutic value TV = NNH/NNT > 5,000. Altogether about 18,000 patients treated with different subtypes of CHM in four different countries have now been evaluated for effects, side effects and adverse events, with similar results.
The Distribution of Cloud Horizontal Sizes

AbstractCloud horizontal size distributions from near-global satellite data, from aircraft, and from a global high-resolution numerical weather prediction model, are presented for the scale range 0.1–8000 km and are shown to be well-represented using a single power-law relationship with an exponent of β = 1.66 ±0.04 from 0.1 to 1500 km or more. At scales longer than 1500 km, there is a statistically significant scale break with fewer very large clouds than expected from the power law. The size distribution is integrated to determine the contribution to cloud cover and visible reflectance from clouds larger than a given size. Globally, clouds with a horizontal dimension of 200 km or more constitute approximately 50% of the cloud cover and 60% of the reflectance, and this result is not sensitive to the minimum size threshold assumed in the integral assuming that the power law can be extrapolated below 100-m scale. The result is also not sensitive to whether the size distribution is determined using cloud se.
Sex differences in blood pressure levels and its association with obesity indices: who is at greater risk.

OBJECTIVE The aim of our study was to investigate blood pressure (BP) levels and their association with different indices of body fat in adult Baniyas. DESIGN AND SETTING A cross-sectional survey was carried out on an endogamous group of 577 adults (307 females and 270 males) aged 25-60 years in Delhi, India. METHODS Data were collected for weight, height, waist circumference and blood pressure using standardized procedure. Body mass index (BMI), waist to hip ratio (WHR), waist to height ratio (WHtR) and grand mean thickness (GMT) were calculated to assess obesity. Also, the sex-specific prevalence estimates for various BP categories was calculated. Correlation was calculated between systolic and diastolic BP and various indices of obesity. Odds ratios for association of hypertension with obesity indices were obtained using multiple logistic regression. RESULTS Prevalence of prehypertension and hypertension was higher among males and prevalence of obesity was higher in females. Correlations of BP with all indices of obesity were significant. Odds ratio of hypertension was higher in males than in females for all the indices of obesity at 95% CI. CONCLUSION Although obesity was found to be higher among females, males were found to be at higher risk of hypertension. High odds ratios of obesity indicate that the optimum cut-off should be calculated for screening those who are at-risk of becoming hypertensive and thus are at the greater risk of developing cardiovascular diseases.
Cardioprotective Effect of Morphine and a Blocker of Glycogen Synthase Kinase 3β, SB216763 [3-(2,4-Dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via Inhibition of the Mitochondrial Permeability Transition Pore

Morphine has been shown to protect the myocardium against ischemia-reperfusion injury through inhibition of glycogen synthase kinase-3β (GSK-3β). Given that GSK-3β is known to modulate the mitochondrial permeability transition pore (mPTP), we investigated the role of mPTP in the cardioprotective effect of morphine and the GSK-3β inhibitor SB216763 [SB; 3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] during ischemia-reperfusion. Both morphine (0.3 mg/kg) and SB (0.6 mg/kg) reduced infarct size in a model of regional myocardial ischemia-reperfusion in rats (13 ± 1 and 14 ± 3% of the area at risk versus 33 ± 4% in controls; p < 0.05). Morphine and SB protected the ischemic myocardium against Ca2+-induced mPTP opening as demonstrated by the increased capacity of mitochondria to retain Ca2+ when they were isolated from the ischemic zone 10 min after the onset of reperfusion (59 ± 8 and 66 ± 3 versus 29.5 ± 6 nmol Ca2+/mg · protein, respectively; p < 0.05). This was associated with a restoration of mitochondrial oxidative phosphorylation parameters. In isolated adult rat cardiomyocytes subjected to anoxia-reoxygenation, morphine (2 μM), SB (3 μM), and the direct mPTP inhibitor cyclosporine A (3 μM) delayed mPTP opening as assessed by the calcein loading Co2+-quenching technique. This was accompanied by an increase in cell survival as measured by nuclear staining with propidium iodide. These in vitro effects of morphine on inhibition of mPTP opening during anoxia-reoxygenation were suppressed by the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor wortmannin (0.1 μM). These data indicate that the infarct-limiting effect of morphine and SB is linked by a cause-effect relationship, which leads to an increased mitochondrial resistance and inhibition of mPTP opening through the PI3-kinase pathway and subsequent inactivation of GSK-3β.
Virtual Engineering Object (VEO): Toward Experience-Based Design and Manufacturing for Industry 4.0

In this article we propose the concept, its framework, and implementation methodology for Virtual Engineering Objects (VEO). A VEO is the knowledge representation of an engineering object that embodies its associated knowledge and experience. A VEO is capable of adding, storing, improving, and sharing knowledge through experience. Moreover, it is demonstrated that VEO is a specialization of a Cyber-Physical System (CPS). In this article, it is shown through test models how the concept of VEO can be implemented with the Set of Experience Knowledge Structure (SOEKS) and Decisional DNA (DDNA). The test model confirmed that the concept of VEO is able to capture and reuse the experience of engineering artifacts, which can be beneficial for efficient decision-making in industrial design and manufacturing.
Mistletoe Infection in an Oak Forest Is Influenced by Competition and Host Size

Host size and distance from an infected plant have been previously found to affect mistletoe occurrence in woody vegetation but the effect of host plant competition on mistletoe infection has not been empirically tested. For an individual tree, increasing competition from neighbouring trees decreases its resource availability, and resource availability is also known to affect the establishment of mistletoes on host trees. Therefore, competition is likely to affect mistletoe infection but evidence for such a mechanism is lacking. Based on this, we hypothesised that the probability of occurrence as well as the abundance of mistletoes on a tree would increase not only with increasing host size and decreasing distance from an infected tree but also with decreasing competition by neighbouring trees. Our hypothesis was tested using generalized linear models (GLMs) with data on Loranthus europaeus Jacq. , one of the two most common mistletoes in Europe, on 1015 potential host stems collected in a large fully mapped plot in the Czech Republic. Because many trees were multi-stemmed, we ran the analyses for both individual stems and whole trees. We found that the probability of mistletoe occurrence on individual stems was affected mostly by stem size, whereas competition had the most important effects on the probability of mistletoe occurrence on whole trees as well as on mistletoe abundance. Therefore, we confirmed our hypothesis that competition among trees has a negative effect on mistletoe occurrence.
Discovery of the Widest Very Low Mass Binary

We report the discovery of a very low mass binary system (primary mass <0.1 M☉) with a projected separation of ~5100 AU, more than twice that of the widest previously known system. A spectrum covering the 1-2.5 μm wavelength interval at R ~ 1700 is presented for each component. Analysis of the spectra indicates spectral types of M6.5 V and M8 V, and the photometric distance of the system is ~62 pc. Given that previous studies have established that no more than 1% of very low mass binary systems have orbits larger than 20 AU, the existence of such a wide system has a bearing on very low mass star formation and evolution models.
Phage inhibition, colicin resistance, and tellurite resistance are encoded by a single cluster of genes on the IncHI2 plasmid R478

A region of the IncHI2 plasmid R478, encoding the phenotypes of tellurite resistance (Ter), phage inhibition (Phi), and colicin resistance (PacB), was cloned and sequenced. Analysis indicated seven open reading frames (ORFs), whose genes were designated terZ, -A, -B, -C, -D, -E, and -F. Five of these predicted ORFs (A to E) had extensive amino acid homology with the previously reported ORFs of the IncHI2 Ter operon from plasmid pMER610. There were domains of highly conserved amino acid residues within the group TerA, -D, -E, and -F and within TerD, -E, and -Z, but no consensus could be found among all five putative polypeptides. There were also regions of good identity and similarity between individual pairs of ORFs which was not reflected in the multiple alignments. The three phenotypes were expressed in Escherichia coli DH5 alpha by an 8.4-kb EcoRI insert subcloned from a cosmid of R478. The latter insert was clonable only as a double insertion with a 4.5-kb fragment, and forced deletion of the smaller fragment was lethal to cells. This lethality was not dependent on the cloned orientation of either fragment, suggesting that there is a trans-acting element in the 4.5-kb fragment. Tn1000 mutagenesis of one of the double-insert clones, pDT2575, showed that the phenotypes, including multiple colicin resistance, were genetically linked. Transpositions into terD, terC, and terZ reduced or abolished all phenotypes, while inserts into terE and terF had no effect on the phenotypes. Insertions in terA reduced phage inhibition levels only. The presence of the terZ and terF ORFs in pMER610 was confirmed, and derivatives of this plasmid mediated Phi, PacB, and Ter.
Wall Teichoic Acid Polymers Are Dispensable for Cell Viability in Bacillus subtilis

ABSTRACT An extensive literature has established that the synthesis of wall teichoic acid in Bacillus subtilis is essential for cell viability. Paradoxically, we have recently shown that wall teichoic acid biogenesis is dispensable in Staphylococcus aureus (M. A. D'Elia, M. P. Pereira, Y. S. Chung, W. Zhao, A. Chau, T. J. Kenney, M. C. Sulavik, T. A. Black, and E. D. Brown, J. Bacteriol. 188:4183-4189, 2006). A complex pattern of teichoic acid gene dispensability was seen in S. aureus where the first gene (tarO) was dispensable and later acting genes showed an indispensable phenotype. Here we show, for the first time, that wall teichoic acid synthesis is also dispensable in B. subtilis and that a similar gene dispensability pattern is seen where later acting enzymes display an essential phenotype, while the gene tagO, whose product catalyzes the first step in the pathway, could be deleted to yield viable mutants devoid of teichoic acid in the cell wall.
Localization of Virtual Objects in the Near Visual Field

We examined errors in the localization of nearby virtual objects presented via see-through helmet-mounted displays as a function of viewing conditions and scene content in four experiments using a total of 38 participants. Monocular, biocular, and stereoscopic presentation of the virtual objects, accommodation (required focus), participants′ age, and the position of physical surfaces were examined. Nearby physical surfaces were found to introduce localization errors that differ depending on the other experimental factors. These errors apparently arise from the occlusion of the physical background by the optically superimposed virtual objects, but they are modified by participants′ accommodative competence and specific viewing conditions. The apparent physical size and transparency of the virtual objects and physical surfaces, respectively, are influenced by their relative position when superimposed. The design implications of the findings are discussed in a concluding section. Head-mounted displays of virtual objects are currently being evaluated as aids for mechanical assembly and equipment maintenance. Other applications include telesurgery, surgical planning, telerobotics, and visualization aids for robotic programming.
Down regulation of macrophage IFNGR1 exacerbates systemic L. monocytogenes infection

Interferons (IFNs) target macrophages to regulate inflammation and resistance to microbial infections. The type II IFN (IFNγ) acts on a cell surface receptor (IFNGR) to promote gene expression that enhance macrophage inflammatory and anti-microbial activity. Type I IFNs can dampen macrophage responsiveness to IFNγ and are associated with increased susceptibility to numerous bacterial infections. The precise mechanisms responsible for these effects remain unclear. Type I IFNs silence macrophage ifngr1 transcription and thus reduce cell surface expression of IFNGR1. To test how these events might impact macrophage activation and host resistance during bacterial infection, we developed transgenic mice that express a functional FLAG-tagged IFNGR1 (fGR1) driven by a macrophage-specific promoter. Macrophages from fGR1 mice expressed physiologic levels of cell surface IFNGR1 at steady state and responded equivalently to WT C57Bl/6 macrophages when treated with IFNγ alone. However, fGR1 macrophages retained cell surface IFNGR1 and showed enhanced responsiveness to IFNγ in the presence of type I IFNs. When fGR1 mice were infected with the bacterium Listeria monocytogenes their resistance was significantly increased, despite normal type I and II IFN production. Enhanced resistance was dependent on IFNγ and associated with increased macrophage activation and antimicrobial function. These results argue that down regulation of myeloid cell IFNGR1 is an important mechanism by which type I IFNs suppress inflammatory and anti-bacterial functions of macrophages.
The Use of Foucault in the Creation of Educational History: A Review of Literature

This research creates a literature review. It investigates the viability of a using Foucauldian critical analysis in creating an educational history. It examines historical methods in education and Foucauldian theory looking for commonalities and offers suggestions on the usage of Foucault in creating history in education. Michel Foucault is often used in education as a theoretical lens through which to view education. His philosophical theory is the basis of numerous far reaching books and articles. There is also another side of Foucault's work. Foucault was also a historian. History grounded Foucault's theory and is an integral part of the lens through which Foucault examined the institutions within France. Research in the field of education tends to focus upon the present. Yet, it is necessary to examine the past to better understand the current happenings in education. A strong and vibrant historical analysis of a field is necessary to keep a field of research integrated within the society in which it exists. Additionally, historical analysis in a field that is directly influenced by political and social influences, such as education, discerns and critiques the "rational" and "unified" cultural understating of the field as presented by the media and political institutions. History takes a myriad of forms; not all of which are appropriate for the creation of this history for education. One of those forms is the critical theory of Michel Foucault, especially his methodology of archaeology. Purpose of Review of Literature This literature review examines history as a method of educational inquiry. It traces a path though critical theory, a tool often used in education, and how it through the work of Michel Foucault can create an educational history. This literature review answers the following question: Is Foucauldian archeology an appropriate method for the creation of educational history? Historiography Edward Augustus Freeman stated, "History is past politics, and politics are present history" (Cunningham, 1976, p. 245). Freeman's definition of history represented the view of history held for much of mankind's existence. Today the primary focus of historians has changed. James Harvey Robinson argued that Freeman's definition of history as the history of politics robs us of much of Man's past. Instead, in New History, Robinson (1958) explored how history comes to bear on the present. Howell and Prevenier (2001) agreed that history analyzes the past in order to better understand today adding that history cannot exist until it is written down. History ages. Stepping back from a work of history, one can have seen the characteristics of the timeframe in which that history was written (Bentley, 1999). Becker (1938) noted that Freeman's view of history is indicative of the 19 th century, a time in which "the major problems of society were political and constitutional, a time when revolutions were primarily concerned with the form of government and the construction of the right kind of constitution" (p. 23). The
VirtualBricks: Exploring a Scalable, Modular Toolkit for Enabling Physical Manipulation in VR

Often Virtual Reality (VR) experiences are limited by the design of standard controllers. This work aims to liberate a VR developer from these limitations in the physical realm to provide an expressive match to the limitless possibilities in the virtual realm. VirtualBricks is a LEGO based toolkit that enables construction of a variety of physical-manipulation enabled controllers for VR, by offering a set of feature bricks that emulate as well as extend the capabilities of default controllers. Based on the LEGO platform, the toolkit provides a modular, scalable solution for enabling passive haptics in VR. We demonstrate the versatility of our designs through a rich set of applications including re-implementations of artifacts from recent research. We share a VR Integration package for integration with Unity VR IDE, the CAD models for the feature bricks, for easy deployment of VirtualBricks within the community.
Efectos emocionales y conductuales de la exposicion a violencia en ninos y adolescentes en Colombia

This study aimed at determining the relationship between various levels of direct and indirect exposure to violence, and victimization, emotional (anxiety and depression), and behavioral (aggression and delinquency) effects in 1362 children and youngsters (56,8% males, 43,2% females), aged 7-8 (14,53%), 910 (64,96%), 11-12 (38,10%) and 13-14 (7,19%), studying 2nd - 5th primary grade and 1st year of secondary, and from three socioeconomic levels (38% high, 26,1% medium and 36% low) from Cali, Colombia. Significant differences were found between levels of total exposure to violence, direct exposure to violence and
On the role of injection in kinetic approaches to non‐linear particle acceleration at non‐relativistic shock waves

The dynamical reaction of the particles accelerated at a shock front by the first-order Fermi process can be determined within kinetic models that account for both the hydrodynamics of the shocked fluid and the transport of the accelerated particles. These models predict the appearance of multiple solutions, all physically allowed. We discuss here the role of injection in selecting the real solution, in the framework of a simple phenomenological recipe, which is a variation of what is sometimes referred to as thermal leakage. In this context we show that multiple solutions basically disappear and when they are present they are limited to rather peculiar values of the parameters. We also provide a quantitative calculation of the efficiency of particle acceleration at cosmic ray modified shocks and we identify the fraction of energy which is advected downstream and that of particles escaping the system from upstream infinity at the maximum momentum. The consequences of efficient particle acceleration for shock heating are also discussed.
Master of all trades: thermal acclimation and adaptation of cardiac function in a broadly distributed marine invasive species, the European green crab, Carcinus maenas

As global warming accelerates, there is increasing concern about how ecosystems may change as a result of species loss and replacement. Here, we examined the thermal physiology of the European green crab (Carcinus maenas Linnaeus 1758), a globally invasive species, along three parallel thermal gradients in its native and invasive ranges. At each site, we assessed cardiac physiology to determine heat and cold tolerance and acclimatory plasticity. We found that, overall, the species is highly tolerant of both heat and cold, and that it survives higher temperatures than co-occurring native marine crustaceans. Further, we found that both heat and cold tolerance are plastic in response to short-term acclimation (18–31 days at either 5 or 25°C). Comparing patterns within ranges, we found latitudinal gradients in thermal tolerance in the native European range and in the invasive range in eastern North America. This pattern is strongest in the native range, and likely evolved there. Because of a complicated invasion history, the latitudinal pattern in the eastern North American invasive range may be due either to rapid adaptation post-invasion or to adaptive differences between the ancestral populations that founded the invasion. Overall, the broad thermal tolerance ranges of green crabs, which may facilitate invasion of novel habitats, derive from high inherent eurythermality and acclimatory plasticity and potentially adaptive differentiation among populations. The highly flexible physiology that results from these capacities may represent the hallmark of a successful invasive species, and may provide a model for success in a changing world.