Miracle-dz/UniFAR-FTUs huggingface dataset:
Phencyclidine and Glutamate Agonist LY379268 Stimulate Dopamine

KEY WORDSglutamate agonist; DA partial agonist; phencyclidine; ketamine; LY 379268; D2 High receptor; schizophrenia ABSTRACTIt has previously been reported that the glutamate ionotropic antago- nist phencyclidine directly inhibits the release of prolactin in anterior pituitary cells in culture, suggesting that phencyclidine has a dopamine (DA)-like action on prolac- tin-releasing cells. It has also been reported that the glutamate metabotropic agonist LY379268 can stimulate the incorporation of ( 35 S)GTP-g-S into DA D2Long receptors. The present study was done to examine whether such glutamatergic drugs had similar actions on the DA D2Short receptor. The present results show that phencyclidine, ke- tamine, and LY379268 also stimulated the incorporation of ( 35 S)GTP-g-S into D2Short receptors. The proportion of D2Long and D2Short receptors existing in the high-affin- ity state were both markedly reduced by NaCl. While phencyclidine and LY379268 each stimulated the incorporation of GTP-g-S into D2Long and D2Short receptors, this stimulation was reduced by NaCl, with D2Short being much more sensitive than D2Long to the inhibition by NaCl. The binding of phencyclidine and LY379268 to D2 High receptors in vivo was directly confirmed by the i.v. injection of phencyclidine and LY379268 in which 50% inhibited the binding of ( 3 H)PHNO to the striatum ex vivo at 0.25 and 1.5 mg/kg, respectively. The results confirm that glutamate agonists and antagonists have a significant affinity for DA D2 High receptors. The psychotogenic action of phencyclidine may stem from a combination or synergistic action of gluta- mate receptor antagonism and DA D2 agonism. In addition, the antipsychotic clinical action of LY379268 congeners such as LY404039 may be related to a combined or syn- ergistic action of glutamate receptor stimulation together with a partial DA agonist action that reduces endogenous DA neurotransmission.Synapse 62:819-828, 2008.
Fiscal Policy in an Estimated DSGE Model of the Japanese Economy: Do Non-Ricardian Households Explain All?

This paper studies how the fiscal authority's financing behavior affects dynamic responses to a government spending shock using an estimated medium-scale dynamic stochastic general equilibrium (DSGE) model of the Japanese economy. The estimated model successfully delivers a positive consumption response regardless of its low share of non-Ricardian households. It points to the importance of the tax rule combination in determining fiscal policy effectiveness, which has been largely omitted in the literature. By conducting some policy experiments, I find that fiscal policy becomes more effective if its finance is allocated lightly on labor-dampening taxes. I also show that a choice of tax rule combination can actually dominate the non-Ricardian share in its effect on fiscal multipliers.
The effects of bilingualism on efficiency and lateralization of attentional networks*

The present study investigated the impact of bilingualism on efficiency of alerting, orienting and executive attention by means of the Lateralized Attention Network Test (LANT). Young adult bilinguals who had been exposed to their second language before the age of four years showed a reduced conflict cost and a larger alerting effect in terms of response time (RT), while no difference between bilinguals and monolinguals was observed in overall RT. Bilinguals also outperformed monolinguals on accuracy in both conflict and non-conflict trials, though the effect in the latter condition was very small. Moreover, while a left visual field advantage for accuracy of conflict resolution was present in the monolingual group, bilinguals did not show the asymmetry. The findings suggest that bilingualism enhances the efficiency of executive network while reducing its lateralization. The larger alerting effect in bilinguals is hypothesized to be related to bilinguals’ more efficient executive control, which may support processes of response anticipation or temporal orienting.
Effect of Tetranychus urticae (Acari: Tetranychidae), on Marketable Yields of Field-Grown Strawberries in North-Central Florida

ABSTRACT Understanding the impact of a pest species on a particular crop is critical for the success of a pest management program. Field studies were conducted to determine the effect of the twospotted spider mite, Tetranychus urticae Koch, on marketable yield of strawberries during the 2008/2009 and 2009/2010 growing seasons. Low, medium, and high mite infestation levels were established by initial inoculations of 5, 10, and 20 twospotted spider mites per strawberry leaf, respectively. A control treatment maintained at near zero mites through applications of an acaricide, bifenazate (Acramite 50 WP), was also included. Weekly records of motile twospotted spider mites were obtained over 13 and 16 wk during the 2008/2009 and 2009/2010 growing seasons, respectively. Degree-days and weather parameters were monitored to determine their effect on mite population. In addition, mite-days were calculated for each year from weekly mite counts to determine the effect of mites on marketable yield of strawberries. In both years, twospotted spider mite population increased throughout the growing seasons. More degree-days were accumulated during the 2008/2009 growing season, and mite population was higher in 2008/2009 than in 2009/2010. Mite population density per leaf increased up to 278 motiles per leaf in 2008/2009 growing season as compared with 137 in 2009/2010 within the high-infestation-level treatment. The divergence in mite population between the two growing seasons was attributed mainly to temperature differences between the two seasons that affected mite population development and establishment. During both growing seasons, the high mite infestation level had lowest marketable yield. A negative correlation between cumulative mite-days and harvested marketable yields was detected in both seasons, but it was only significant during the 2008/2009 growing season. Strawberry yield reduction was detected when plants attained 80 mites per leaf in 2008/2009 and 50 mites per leaf in 2009/2010 within the high mite infestation treatment. Factors that affect mite population establishment and management for twospotted spider mites on strawberries are discussed.
Population dynamics and ecology of Arcobacter in sewage

Arcobacter species are highly abundant in sewage where they often comprise approximately 5–11% of the bacterial community. Oligotyping of sequences amplified from the V4V5 region of the 16S rRNA gene revealed Arcobacter populations from different cities were similar and dominated by 1–3 members, with extremely high microdiversity in the minor members. Overall, nine subgroups within the Arcobacter genus accounted for >80% of the total Arcobacter sequences in all samples analyzed. The distribution of oligotypes varied by both sample site and temperature, with samples from the same site generally being more similar to each other than other sites. Seven oligotypes matched with 100% identity to characterized Arcobacter species, but the remaining 19 abundant oligotypes appear to be unknown species. Sequences representing the two most abundant oligotypes matched exactly to the reference strains for A. cryaerophilus group 1B (CCUG 17802) and group 1A (CCUG 17801T), respectively. Oligotype 1 showed generally lower relative abundance in colder samples and higher relative abundance in warmer samples; the converse was true for Oligotype 2. Ten other oligotypes had significant positive or negative correlations between temperature and proportion in samples as well. The oligotype that corresponded to A. butzleri, the Arcobacter species most commonly isolated by culturing in sewage studies, was only the eleventh most abundant oligotype. This work suggests that Arcobacter populations within sewer infrastructure are modulated by temperature. Furthermore, current culturing methods used for identification of Arcobacter fail to identify some abundant members of the community and may underestimate the presence of species with affinities for growth at lower temperatures. Understanding the ecological factors that affect the survival and growth of Arcobacter spp. in sewer infrastructure may better inform the risks associated with these emerging pathogens.
LOCALIZATION OF SHORT DURATION GRAVITATIONAL-WAVE TRANSIENTS WITH THE EARLY ADVANCED LIGO AND VIRGO DETECTORS

The Laser Interferometer Gravitational wave Observatory (LIGO) and Virgo advanced ground-based gravitational-wave detectors will begin collecting science data in 2015. With first detections expected to follow, it is important to quantify how well generic gravitational-wave transients can be localized on the sky. This is crucial for correctly identifying electromagnetic counterparts as well as understanding gravitational-wave physics and source populations. We present a study of sky localization capabilities for two search and parameter estimation algorithms: coherent WaveBurst, a constrained likelihood algorithm operating in close to real-time, and LALInferenceBurst, a Markov chain Monte Carlo parameter estimation algorithm developed to recover generic transient signals with latency of a few hours. Furthermore, we focus on the first few years of the advanced detector era, when we expect to only have two (2015) and later three (2016) operational detectors, all below design sensitivity. These detector configurations can produce significantly different sky localizations, which we quantify in detail. We observe a clear improvement in localization of the average detected signal when progressing from two-detector to three-detector networks, as expected. Although localization depends on the waveform morphology, approximately 50% of detected signals would be imaged after observing 100–200 deg2 in 2015 and 60–110 deg2 in 2016, although knowledge of the waveform can reduce this to as little as 22 deg2. This is the first comprehensive study on sky localization capabilities for generic transients of the early network of advanced LIGO and Virgo detectors, including the early LIGO-only two-detector configuration.
Heart rate variability and its changes over 5 years in older adults.

PURPOSE to characterise the association between age, ageing and heart rate variability (HRV) in older individuals, 585 adults age >65 years with two 24-h Holter recordings in the Cardiovascular Health Study were studied. METHODS heart rate (HR), ventricular premature contractions (VPCs), atrial premature contractions (APCs), frequency-domain, ratio-based and non-linear HRV and heart rate turbulence (HRT) were examined cross-sectionally by 5-year age groups and prospectively over 5 years. Analyses adjusted for gender, lower versus elevated cardiovascular (CV) risk and for the change in CV risk. RESULTS HR declined, and VPCs and APCs increased per 5-year increase in age. Frequency-domain HRV decreased more at 65-69, less at 70-74 and minimally at > or =75 years, independent of CVD risk or change in CVD risk. Ratio and non-linear HRV continued to decline to > or =75 years old. Ratio HRV and HRT slope were more strongly related to CVD risk than frequency-domain HRV. CONCLUSIONS cardiac autonomic function, assessed by frequency-domain HRV, declines most at 65-70 and levels off at age >75. The decline is independent of CVD risk or change in CVD risk. Ratio-based and non-linear HRV and HRT slope continued to change with increasing age and were more closely related to CVD risk than frequency-domain HRV.
Nominalizations as complex strategies of politeness and face-work in scientific papers written in Brazilian Portuguese

In this paper, we depart from the hypothesis that face-work is an important dimension of the construction of discourse, regardless the register (oral or written). Drawing on the framework of Pragmatics, we argue that instances of nominalization can operate as politeness strategies, in the sense that they permit, on the one hand, the omission of the actor/agent of a given verbal event and, on the other hand, they contribute to establishing the boundaries of social distance and power relations, as a pervasive feature of formal texts. The empirical data analyzed in this study include academic papers taken from the Academic Corpus of Brazilian Portuguese (CAPB). In the academic papers analyzed, nominalizations operated, to a large degree, as a strategy to mitigate the potential attacks on the positive face of the author himself, acting, therefore, as a strategy of positive politeness.
El Resumen de artículos de investigación científica: Variación disciplinar a nivel local y global

El objetivo del presente estudio es comparar el resumen de articulos de investigacion cientifica (AICs) de dos disciplinas (Biologia e Historia) a partir de su organizacion retorica y de las relaciones de coherencia que lo configuran. Para describir la organizacion retorica, utilizamos, como taxonomia de arranque, la propuesta de Hyland (2000) , mientras que para las relaciones de coherencia, utilizamos la propuesta de Ibanez, Moncada y Santana (2015) . El corpus de esta investigacion estuvo constituido por 160 resumenes escritos en espanol, pertenecientes a AICs publicados en revistas especializadas. Los resultados revelan que mientras ciertas movidas son obligatorias en los resumenes de una disciplina, en los de la otra son opcionales. Tambien se observa que los resumenes de ambas disciplinas se diferencian en sus configuraciones retoricas prototipicas, al igual que en las relaciones de coherencia mas frecuentes.
Rolling Shutter Super-Resolution

Classical multi-image super-resolution (SR) algorithms, designed for CCD cameras, assume that the motion among the images is global. But CMOS sensors that have increasingly started to replace their more expensive CCD counterparts in many applications do not respect this assumption if there is a motion of the camera relative to the scene during the exposure duration of an image because of the row-wise acquisition mechanism. In this paper, we study the hitherto unexplored topic of multi-image SR in CMOS cameras. We initially develop an SR observation model that accounts for the row-wise distortions called the "rolling shutter" (RS) effect observed in images captured using non-stationary CMOS cameras. We then propose a unified RS-SR framework to obtain an RS-free high-resolution image (and the row-wise motion) from distorted low-resolution images. We demonstrate the efficacy of the proposed scheme using synthetic data as well as real images captured using a hand-held CMOS camera. Quantitative and qualitative assessments reveal that our method significantly advances the state-of-the-art.
Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma

Rhabdomyosarcoma (RMS), a cancer characterized by features of skeletal muscle histogenesis, is the most common soft tissue sarcoma of childhood and adolescence. Survival for high-risk groups is less than 30% at 5 years. RMS also occurs during adulthood, with a lower incidence but higher mortality. Recently, mutational profiling has revealed a correlation between activating Ras mutations in the embryonal (eRMS) and pleomorphic (pRMS) histologic variants of RMS, and a poorer outcome for those patients. Independently, the YAP transcriptional coactivator, an oncoprotein kept in check by the Hippo tumor suppressor pathway, is upregulated in eRMS. Here we show that YAP promotes cell proliferation and antagonizes apoptosis and myogenic differentiation of human RMS cells bearing oncogenic Ras mutations in cell culture studies in vitro and in murine xenografts in vivo. Pharmacologic inhibition of YAP by the benzoporphyrin derivative verteporfin decreased cell proliferation and tumor growth in vivo. To interrogate the temporal contribution of YAP in eRMS tumorigenesis, we used a primary human cell-based genetic model of Ras-driven RMS. Constitutively active YAP functioned as an early genetic lesion, permitting bypass of senescence and priming myoblasts to tolerate subsequent expression of hTERT and oncogenic Ras, which were necessary and sufficient to generate murine xenograft tumors mimicking RMS in vivo. This work provides evidence for cooperation between YAP and oncogenic Ras in RMS tumorigenesis, laying the foundation for preclinical co-targeting of these pathways.
Treatment of Infective Endocarditis: A 10-Year Comparative Analysis

SUMMARY The results of surgical and non-surgical treatment of active infective endocarditis in 182 patients over a 10-year period were analyzed. Heart failure, annular and myocardial abscesses, heart block, and coronary embolism, seen most frequently with staphylococcal and fungal endocarditis, were the primary causes of death in both native valve endocarditis (NVE) and prosthetic valve endocarditis (PVE). In NVE, surgery significantly improved the survival in patients with moderate or severe heart failure (P < 0.05) and in all patients with staphylococcal endocarditis (P < 0.03). In PVE, surgery significantly influenced survival in patients with moderate or severe heart failure (P < 0.05) and in the entire group with late PVE (P < 0.01). Early surgery is recommended for patients with native valve endocarditis and moderate or severe heart failure; those patients with staphylococcal NVE, regardless of hemodynamic state, should undergo early valve replacement. Early surgery is recommended for PVE patients with moderate or severe heart failure. We also recommend early valve replacement for early and late staphylococcal PVE.
Spinal Vascular Endothelial Growth Factor Induces Phrenic Motor Facilitation via Extracellular Signal-Regulated Kinase and Akt Signaling

Although vascular endothelial growth factor (VEGFA-165) is primarily known for its role in angiogenesis, it also plays important neurotrophic and neuroprotective roles for spinal motor neurons. VEGFA-165 signals by activating its receptor tyrosine kinase VEGF receptor-2 (VEGFR-2). Because another growth/trophic factor that signals via a receptor tyrosine kinase (brain derived neurotrophic factor) elicits a long-lasting facilitation of respiratory motor activity in the phrenic nerve, we tested the hypothesis that VEGFA-165 elicits similar phrenic motor facilitation (pMF). Using immunohistochemistry and retrograde labeling techniques, we demonstrate that VEGFA-165 and VEGFR-2 are expressed in identified phrenic motor neurons. Furthermore, intrathecal VEGFA-165 administration at C4 elicits long-lasting pMF; intraspinal VEGFA-165 increased integrated phrenic nerve burst amplitude for at least 90 min after injection (53.1 ± 5.0% at 90 min; p < 0.001). Intrathecal VEGFA-165 increased phosphorylation (and presumed activation) of signaling molecules downstream from VEGFR-2 within the phrenic motor nucleus, including ERK (1.53 ± 0.13 vs 1.0 ± 0.05 arbitrary units in control rats; p < 0.05) and Akt (2.16 ± 0.41 vs 1.0 ± 0.41 arbitrary units in control rats; p < 0.05). VEGF-induced pMF was attenuated by the MEK/ERK inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene] and was abolished by the phosphotidinositol 3 kinase/Akt inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], demonstrating that ERK mitogen-activated protein kinases and Akt are both required for full expression of VEGF-induced pMF. This is the first report that VEGFA-165 elicits plasticity in any motor system. Furthermore, because VEGFA-165 expression is hypoxia sensitive, it may play a role in respiratory plasticity after prolonged exposures to low oxygen.
Sexuality of adults with intellectual disabilities as described by support staff workers

Historically, people with intellectual disabilities have been labeled as asexual or as perpetrators or victims of sexual abuse (McDaniels, Fleming, 2016). They often face discrimination because of their sexuality, regardless of whether they live within residential facilities or family homes (Wingles-Yanez, 2014). This paper presents research results from qualitative studies of the sexuality of adults with intellectual disabilities. Applying a phenomenographic method (Paulston, 1993), the authors conducted 16 interviews with professionals at several daycare and residential centres in north-eastern Poland who work with intellectually disabled people. The specific research aims were to answer the following questions: (1) How do support staff workers perceive sexuality and intimate relationships of adults with intellectual disabilities? (2) Which factors contribute to the sexuality and intimate relationships of adults with intellectual disabilities according to support staff workers? (3) What kinds of support related to sexuality and intimate relationships do support staff workers think is essential for people with intellectual disabilities? The authors focus on presenting the professionals’ perceptions of sexuality and intimate relationships of adults with intellectual disabilities and to depict the discourse those workers use. Implications for practice are also discussed, especially the need to provide sexuality support to adults with intellectual disabilities, their therapists and parents.
Theory of attentional operations in shape identification.

This article presents a theory of selective attention that is intended to account for the identification of a visual shape in a cluttered display. The selected area of attention is assumed to be controlled by a filter that operates on the location information in a display. The location information selected by the filter in turn determines the feature information that is to be identified. Changes in location of the selected area are assumed to be governed by a gradient of processing resources. Data from three new experiments are fit more parsimoniously by a gradient model than by a moving-spotlight model. The theory is applied to experiments in the recent literature concerned with precuing locations in the visual field, and to the issue of attentional and automatic processing in the identification of words. Finally, data from neuroanatomical experiments are reviewed to suggest ways that the theory might be realized in the primate brain.
Error Analysis of a Second-Order Locally Implicit Method for Linear Maxwell's Equations

In this paper we consider the full discretization of linear Maxwell's equations on spatial grids which are locally refined. For such problems, explicit time integration schemes become inefficient because the smallest mesh width results in a strict CFL condition. Recently locally implicit time integration methods have become popular in overcoming the problem of so-called grid-induced stiffness. Various such schemes have been proposed in the literature and have been shown to be very efficient. However, a rigorous analysis of such methods is still lacking. In fact, the available literature focuses on error bounds which are valid on a fixed spatial mesh only but deteriorate in the limit where the smallest spatial mesh size tends to zero. Moreover, some important questions cannot be answered without such an analysis. For example, there has been no study of which elements of the spatial mesh enter the CFL condition. In this paper we provide such a rigorous analysis for a locally implicit scheme proposed by Verw.