Miracle-dz/UniFAR-FTUs huggingface dataset:
Atrial Natriuretic Factor Modulates Proximal Glomerulotubular Balance in Anesthetized Rats

&NA; The extent to which the natriuretic effect of a prolonged low dose infusion of atrial natriuretic factor (30 ng/kg/min) is dependent on interference with the prevailing intrarenal actions of angiotensin II was examined before and after blockade of angiotensin production with the converting enzyme inhibitor enalaprilat (5 mg/kg). Lithium clearance was used to assess proximal tubular sodium and water reabsorption. Atrial natriuretic factor and enalaprilat caused similar increases in sodium excretion (10‐fold and sevenfold, respectively) and glomerular filtration rate (each 34%) and similar decreases in fractional proximal reabsorption of sodium (17% and 13%, respectively) and blood pressure. Each also caused a major disruption in the effectiveness of proximal glomerulotubular balance (30% and 50% of perfect balance). Infusion of atrial natriuretic factor during converting enzyme inhibition increased glomerular filtration rate further by 23%, reaching 63% above control without change in renal blood flow but with a rise in filtration fraction to 0.48. Sodium excretion increased further but fractional proximal sodium reabsorption remained constant and proximal glomerulotubular balance appeared to improve. Atrial natriuretic factor therefore possesses a glomerular action that persists during converting enzyme inhibition and is indeed additive to the removal of angiotensin II when the proximal effect of atrial natriuretic factor is no longer apparent. It is concluded that failure of atrial natriuretic factor to further suppress fractional proximal sodium reabsorption during converting enzyme inhibition is caused by either prior removal of the stimulatory action of angiotensin II on proximal tubular transport or extreme changes in peritubular physical factors consequent on the high filtration fraction. (Hypertension 1989;14:666‐673)
Circadian preference, sleep and daytime behaviour in adolescence

The aim of this study was to determine the relationship between circadian preferences, regularity of sleep patterns, sleep problems, daytime sleepiness and daytime behaviour. As a part of an epidemiological survey on sleep in a representative sample of Italian high‐school students, a total of 6631 adolescents, aged 14.1–18.6 years, completed the School Sleep Habits Survey, a comprehensive questionnaire including items regarding sleep, sleepiness, substance use, anxiety and depressed mood, use of sleeping pills, school attendance and a morningness/eveningness scale. The sample consisted of 742 evening‐types (315 males and 427 females; mean age 17.1 years) and 1005 morning‐types (451 males and 554 females; mean age 16.8 years). No significant sex differences were found for morningness/eveningness score. Eveningness was associated with later bedtime and wake‐up time, especially on weekends, shorter time in bed during the week, longer weekend time in bed, irregular sleep–wake schedule, subjective poor sleep. Moreover, evening types used to nap more frequently during school days, complained of daytime sleepiness, referred more attention problems, poor school achievement, more injuries and were more emotionally upset than the other chronotype. They referred also greater caffeine‐containing beverages and substances to promote sleep consumption. Our results suggest that circadian preference might be related not only to sleep pattern, but also to other adolescent behaviours.
EFFECTS OF ADAPTATION ON RESPONSES IN A SOMATOSENSORY THALAMOCORTICAL CIRCUIT

Vivek Khatri, PhD University of Pittsburgh, 2005 In the mammalian brain, thalamocortical circuits perform the initial stage of processing before information is sent to higher levels of the cerebral cortex. Substantial changes in receptive field properties are produced in the thalamocortical response transformation. In the whisker-to-barrel thalamocortical pathway, the response magnitude of barrel excitatory cells is sensitive to the velocity of whisker deflections, whereas in the thalamus, velocity is only encoded by firing synchrony. The behavior of this circuit can be captured in a model which contains a window of opportunity for thalamic firing synchrony to engage intra-barrel recurrent excitation before being ‘damped’ by slightly delayed, but strong, local feedforward inhibition. Some remaining aspects of the model that require investigation are: (1) how does adaptation with ongoing and repetitive sensory stimulation affect processing in this circuit and (2) what are the rules governing intra-barrel interactions. By examining sensory processing in thalamic barreloids and cortical barrels, before and after adaptation with repetitive high-frequency whisker stimulation, I have determined that adaptation modifies the operations of the thalamocortical circuit without fundamentally changing it. In the non-adapted state, higher velocities produce larger responses in barrel cells than lower velocities. Similarly, in the adapted barrel, putative excitatory and inhibitory neurons can respond with temporal iv
The ABCG2 C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects.

AIMS A number of drugs are substrates or inhibitors of the efflux transporter breast cancer resistance protein (BCRP; ABCG2), which can limit systemic exposure by reducing absorption and/or increasing biliary elimination. The identification of a BCRP-selective clinical probe drug would provide a useful tool to understand the effect of genetic polymorphisms and transporter-based drug interactions on drug pharmacokinetics. The aim of this study was to assess the utility of nitrofurantoin as a clinical probe substrate for BCRP activity by evaluating the impact of genetic variation on nitrofurantoin pharmacokinetics. METHODS Nitrofurantoin pharmacokinetics were studied in an open-label, single-oral dose (100 mg) study in 36 male Chinese subjects who were pre-screened for ABCG2 421 CC, CA and AA genotypes (n = 12 each). Plasma and urine concentrations of nitrofurantoin were determined by LC/MS/MS and LC/UV respectively. anova was used to compare pharmacokinetic parameters among genotypes. RESULTS There were no significant differences in nitrofurantoin pharmacokinetics among the genotypic cohorts. The geometric mean nitrofurantoin plasma AUC((0-infinity)) (95% confidence interval) values were 2.21 (2.00, 2.45), 2.42 (2.11, 2.78) and 2.32 (1.99, 2.70) microg h ml(-1) and half-life values were 0.79 (0.59, 1.0), 0.76 (0.64, 0.89) and 0.72 (0.62, 0.84) h for ABCG2 421 genotypes CC, CA and AA, respectively. The percentage of dose excreted unchanged in the urine was 43, 44 and 39%, respectively. CONCLUSIONS The ABCG2 C421A polymorphism had no effect on nitrofurantoin plasma and urine pharmacokinetic parameters in healthy Chinese subjects. These results indicate that nitrofurantoin is not a suitable clinical probe substrate for assessing BCRP activity.
Tracking of time-varying grid voltage using DFT based second order generalized integrator technique

This paper proposes a robust, fast and accurate estimation technique for the tracking of time-varying grid voltage parameters. The proposed technique consists of a fundamental frequency tracking method based on a fixed window discrete Fourier transform (DFT) and a quadrature signal generator (QSG) based on a second order generalized integrator (SOGI) in order to track the fundamental amplitude and phase angle. The spectral leakage property of the fixed window DFT is used to track the time-varying fundamental frequency which is subsequently used as the resonance frequency of the QSG-SOGI to generate the orthogonal waveforms of the grid voltage fundamental component. The performance of the proposed DFT based SOGI technique is also compared with the frequency locked loop (FLL) based QSG-SOGI (SOGI-FLL), phase-locked loop (PLL) based on the QSG-SOGI (SOGI-PLL) and quadrature PLL (QPLL) techniques. The superior performance of the proposed technique is verified using synthetically generated grid voltage waveforms in MATLAB/Simulink.
National Patterns of Codeine Prescriptions for Children in the Emergency Department

BACKGROUND AND OBJECTIVES: National guidelines have recommended against codeine use in children, but little is known about prescribing patterns in the United States. Our objectives were to assess changes over time in pediatric codeine prescription rates in emergency departments nationally and to determine factors associated with codeine prescription. METHODS: We performed a serial cross-sectional analysis (2001–2010) of emergency department visits for patients ages 3 to 17 years in the nationally representative National Hospital Ambulatory Medical Care Survey. We determined survey-weighted annual rates of codeine prescriptions and tested for linear trends over time. We used multivariate logistic regression to identify characteristics associated with codeine prescription and interrupted time-series analysis to assess changes in prescriptions for upper respiratory infection (URI) or cough associated with two 2006 national guidelines recommending against its use for these indications. RESULTS: The proportion of visits (N = 189 million) with codeine prescription decreased from 3.7% to 2.9% during the study period (P = .008). Odds of codeine prescription were higher for children ages 8 to 12 years (odds ratio [OR], 1.42; 95% confidence interval [1.21–1.67]) and among providers outside the northeast. Odds were lower for children who were non-Hispanic black (OR, 0.67 [0.56–0.8]) or with Medicaid (OR, 0.84 [0.71–0.98]). The 2006 guidelines were not associated with a decline in codeine prescriptions for cough or URI visits. CONCLUSIONS: Although there was a small decline in codeine prescription over 10 years, use for cough or URI did not decline after national guidelines recommending against its use. More effective interventions are needed to prevent codeine prescription to children.
The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway

Polycomb group protein enhancer of zeste homolog 2 (EZH2) is a methyltransferase that correlates with the regulation of invasion and metastasis and is overexpressed in human cancers such as colorectal cancer. MicroRNA-31 (miR-31) plays an oncogenic role and is associated with BRAF mutation and poor prognosis in colorectal cancer. EZH2 is functionally considered to suppress miR-31 expression in human cancers; however, no study has reported its relationship with colon cancer. We therefore evaluated EZH2 expression using immunohistochemistry and assessed miR-31 and epigenetic alterations using 301 colorectal carcinomas and 207 premalignant lesions. Functional analysis was performed to identify the association between EZH2 and miR-31 using cancer cell lines. In the current study, negative, weak, moderate, and strong EZH2 expressions were observed in 15%, 19%, 25%, and 41% of colorectal cancers, respectively. EZH2 was inversely associated with miR-31 (P < 0.0001), independent of clinicopathological and molecular features. In a multivariate stage-stratified analysis, high EZH2 expression was related to favorable prognosis (P = 0.0022). Regarding premalignant lesions, negative EZH2 expression was frequently detected in sessile serrated adenomas/polyps (SSA/Ps) (76%; P < 0.0001) compared with hyperplastic polyps, traditional serrated adenomas, and non-serrated adenomas (25–36%). Functional analysis demonstrated that the knockdown of EZH2 increased miR-31 expression. In conclusion, an inverse association was identified between EZH2 and miR-31 in colorectal cancers. Our data also showed that upregulation of EZH2 expression may be rare in SSA/Ps. These results suggest that EZH2 suppresses miR-31 in colorectal cancer and may correlate with differentiation and evolution of serrated pathway.
Beyond focal cortical lesions in MS

Objectives: Using quantitative T2* 7-tesla (7T) MRI as a marker of demyelination and iron loss, we investigated, in patients with relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), spatial and tissue intrinsic characteristics of cortical lesion(s) (CL) types, and structural integrity of perilesional normal-appearing cortical gray matter (NACGM) as a function of distance from lesions. Methods: Patients with MS (18 RRMS, 11 SPMS), showing at least 2 CL, underwent 7T T2* imaging to obtain (1) magnitude images for segmenting focal intracortical lesion(s) (ICL) and leukocortical lesion(s) (LCL), and (2) cortical T2* maps. Anatomical scans were collected at 3T for cortical surface reconstruction using FreeSurfer. Seventeen age-matched healthy participants served as controls. Results: ICL were predominantly located in sulci of frontal, parietal, and cingulate cortex; LCL distribution was more random. In MS, T2* was higher in both ICL and LCL, indicating myelin and iron loss, than in NACGM (p < 0.00003) irrespective of CL subtype and MS phenotype. T2* was increased in perilesional cortex, tapering away from CL toward NACGM, the wider changes being for LCL in SPMS. NACGM T2* was higher in SPMS relative to RRMS (p = 0.006) and healthy cortex (p = 0.02). Conclusions: CL had the same degree of demyelination and iron loss regardless of lesion subtype and disease stage. Cortical damage expanded beyond visible CL, close to lesions in RRMS, and more diffusely in SPMS. Evaluation of NACGM integrity, beyond focal CL, could represent a surrogate marker of MS progression.
Continuous subcutaneous insulin infusion versus multiple daily injections in pregnant women with type 1 diabetes.

BACKGROUND Continuous subcutaneous insulin infusion (CSII) may be an alternative to multiple daily injections (MDI) in pre-gestational diabetes during pregnancy. However, no clear improvement in obstetric and perinatal outcome has so far been established for CSII treatment. METHODS In a case-control study, 35 pregnancies treated with CSII and 64 pregnancies treated with MDI treatment were evaluated. Metabolic control and obstetric and perinatal outcome were compared. RESULTS Women in the CSII group improved their metabolic control (hemoglobin A1c before CSII, 7.83 +/- 0.97%; 3-6 months after, 6.77 +/- 0.61%; P < 0.05). Hemoglobin A1c before pregnancy was lower in the CSII group (6.62 +/- 0.60%) than in the MDI group (7.59 +/- 1.61%) (P < 0.05). No other significant differences, either in metabolic control of diabetes or in obstetric and perinatal outcome, were found. CONCLUSIONS CSII treatment is safe in pregnancy, but it has not yet been associated with any improved pregnancy outcome.
Zero-Shot Domain Adaptation via Kernel Regression on the Grassmannian

Most visual recognition methods implicitly assume the data distribution remains unchanged from training to testing. However, in practice domain shift often exists, where real-world factors such as lighting and sensor type change between train and test, and classifiers do not generalise from source to target domains. It is impractical to train separate models for all possible situations because collecting and labelling the data is expensive. Domain adaptation algorithms aim to ameliorate domain shift, allowing a model trained on a source to perform well on a different target domain. However, even for the setting of unsupervised domain adaptation, where the target domain is unlabelled, collecting data for every possible target domain is still costly. In this paper, we propose a new domain adaptation method that has no need to access either data or labels of the target domain when it can be described by a parametrised vector and there exits several related source domains within the same parametric space. It greatly reduces the burden of data collection and annotation, and our experiments show some promising results.
Thinning Methodologies - A Comprehensive Survey

A comprehensive survey of thinning methodologies is presented. A wide range of thinning algorithms, including iterative deletion of pixels and nonpixel-based methods, is covered. Skeletonization algorithms based on medial axis and other distance transforms are not considered. An overview of the iterative thinning process and the pixel-deletion criteria needed to preserve the connectivity of the image pattern is given first. Thinning algorithms are then considered in terms of these criteria and their modes of operation. Nonpixel-based methods that usually produce a center line of the pattern directly in one pass without examining all the individual pixels are discussed. The algorithms are considered in great detail and scope, and the relationships among them are explored. >
Yields of rotating stars at solar metallicity

We present a new set of stellar yields obtained from rotating stellar models at solar metallicity covering the massive star range (12-60 $M_{\odot}$). The stellar models were calculated with the latest version of the Geneva stellar evolution code described in Hirschi et al. (2004). Evolution and nucleosynthesis are in general followed up to silicon burning. The yields of our non-rotating models are consistent with other calculations and differences can be understood in the light of the treatment of convection and the rate used for 12 C$(\alpha,\gamma)^{16}$O. This verifies the accuracy of our calculations and gives a safe basis for studying the effects of rotation on the yields. The contributions from stellar winds and supernova explosions to the stellar yields are presented separately. We then add the two contributions to compute the total stellar yields. Below ${\sim} 30\,M_{\odot}$, rotation increases the total metal yields, Z , and in particular the yields of carbon and oxygen by a factor of 1.5-2.5. As a rule of thumb, the yields of a rotating 20 $M_\odot$ star are similar to the yields of a non-rotating 30 $M_\odot$ star, at least for the light elements considered in this work. For very massive stars (${\sim} 60\,M_{\odot}$), rotation increases the yield of helium but does not significantly affect the yields of heavy elements.
Gender Trends in Radiology Authorship: A 35-Year Analysis.

OBJECTIVE The purpose of this study was to describe trends over time in female authorship in the radiology literature and to investigate the tendency of female first authors to publish with female senior authors. MATERIALS AND METHODS Data on the gender of academic physician authors based in the United States for all major articles published in three general radiology journals--Radiology, AJR, and Academic Radiology--were collected and analyzed for the years 1978, 1988, 1998, 2008, and 2013. Multivariate logistic regression was used to identify significant trends over time, and a chi-square test of independence was performed to determine significant relations between the genders of first and senior authors. RESULTS The gender of 4182 of 4217 (99.17%) authors with MD degrees was determined. The proportion of original research articles published by women as first authors increased from 8.33% in 1978 to 32.35% in 2013 (p < 0.001). The proportion of original research articles with women as senior authors increased from 6.75% in 1978 to 21.90% in 2013 (p < 0.001). Female first and senior authorship increased significantly over time (first author, p < 0.001; senior author, p < 0.001). There was a statistically significant relation between the genders of first and senior authors of original research articles and guest editorials (p < 0.001). CONCLUSION Over 35 years, there was a statistically significant upward linear trend of female physician participation in authorship of academic radiology literature. Female first authors were more likely to publish with female senior authors.
Constrained coding techniques for the suppression of intrachannel nonlinear effects in high-speed optical transmission

A problem of suppression of intrachannel nonlinearities through the use of constrained coding is considered. Three different techniques are proposed and compared with respect to their efficiency, namely 1) constrained coding; 2) combined constrained and error control coding; and 3) deliberate error insertion. Significant Q-factor improvement up to 16 dB depending on code rate and number of spans is demonstrated. A combined constrained-iterative forward error correction (FEC) scheme can operate in the presence of strong intrachannel nonlinearities when even advanced FEC schemes would be overwhelmed with errors. It provides a coding gain of 12.1 dB at a bit error rate (BER) of 10/sup -9/. Deliberate error insertion is an efficient approach to balance the encoder complexity and the achievable coding gain.
University Drop-Outs. A Systemic Play of Subjects, Institutions and Macro Contexts

This paper is a part of a wider research program concerning the assessment of quality at University. It was selected by the Department of University Policies (Ministry of Education, Science and Innovation) in an attempt to determine the causes and “reasons” underlying dropping school in our country. The Program includes three sub-projects concerning both academic and socio-professional success, delay and failure (dropping out). Our specific aim here is to determine the psychosocial reasons for failure at University (qualitative aspect). The sample includes University students who quit studies at UNCuyo in a period of nearly 20 years (1987-2004). A quanti-qualitative methodology was applied so as to be able to explain and more fully understand the importance of the causes and the reasons underlying their quitting. 212 indicators were used. Results show different profiles connected with the same variables/psychosocial dimensions (n-ach, expectations, fatalism, self-efficacy, life projects, social representations of the importance of university degrees in relation with insertion in the labor market, etc) underlying drop-outs. DOI: 10.5901/jesr.2014. v4n2p466
Integrating Task- and Work Domain-Based Work Analyses in Ecological Interface Design: A Process Control Case Study

In this paper, we present a case study wherein several work analysis methods were incorporated in the design of a graphical interface for a petrochemical production process. We follow this case from the application of the work analysis methods, through the consolidation of information requirements, to the design of a novel interface that integrates the requirements. The findings confirm earlier assertions that task-based and work domain-based analysis frameworks identify unique and complementary requirements for effective information systems that are intended to support supervisory control of complex systems. It further provides the first industrial demonstration of ecological interface forms based on integrated task-and work domain-based work requirements.