Miracle-dz/UniFAR-FTUs huggingface dataset:
Cellular Neuroscience

GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder in humans characterized by progressive degeneration of skeletal muscle and motor neurons in spinal cord, brainstem, and cerebral cortex causing skeletal muscle paralysis, respiratory insufficiency, and death. There are no cures or effective treatments for ALS. ALS can be inherited, but most cases are not associated with a family history of the disease. Mitochondria have been implicated in the pathogenesis but definitive proof of causal mechanisms is lacking. Identification of new clinically translatable disease mechanism-based molecular targets and small molecule drug candidates are needed for ALS patients. We tested the hypothesis in an animal model that drug modulation of the mitochondrial permeability transition pore (mPTP) is therapeutic in ALS. A prospective randomized placebo-controlled drug trial was done in a transgenic (tg) mouse model of ALS. We explored GNX-4728 as a therapeutic drug. GNX-4728 inhibits mPTP opening as evidenced by increased mitochondrial calcium retention capacity (CRC) both in vitro and in vivo. Chronic systemic treatment of G37R-human mutant superoxide dismutase-1 (hSOD1) tg mice with GNX-4728 resulted in major therapeutic benefits. GNX-4728 slowed disease progression and significantly improved motor function. The survival of ALS mice was increased significantly by GNX-4728 treatment as evidence by a nearly 2-fold extension of lifespan (360 days– 750 days). GNX-4728 protected against motor neuron degeneration and mitochondrial degeneration, attenuated spinal cord inflammation, and preserved neuromuscular junction (NMJ) innervation in the diaphragm in ALS mice. This work demonstrates that a mPTP-acting drug has major disease-modifying efficacy in a preclinical mouse model of ALS and establishes mitochondrial calcium retention, and indirectly the mPTP, as targets for ALS drug development.
[Sleep habits and starting time to school in Brazilian children].

OBJECTIVE This study investigated the sleep habits in Brazilian children according to age, gender and starting time to school. METHOD We investigated 2,482 scholars aged 7 to 10 years. We compared sleep habits, gender, and starting time to school (morning and afternoon). RESULTS Sixty-one per cent of the children presented sleep rituals before sleep. Milk drinking before sleep was more frequent among seven years old children. We found a progressive reduction with age in keeping the lights on. Girls used to leave an object to bed more than boys did. Children that studied in the morning presented reduced total sleep time, sleep earlier, and nap more frequently than children that studied in the afternoon. CONCLUSION Starting time to school deeply influences sleep habits in Brazilian children from São Paulo City, in whom bed-time rituals are highly prevalent.
Hyperphosphatemia in Renal Failure

The recent recognition that hyperphosphatemia is a strong predictor of survival on dialysis has rekindled interest in the regulation and control of serum phosphate. In incipient renal failure hyperphosphatemia is prevented by increased fractional renal phosphate excretion mediated via an increase in parathyroid hormone and the novel phosphaturic hormone FGF-23 (and possibly others). At a glomerular filtration rate of approximately 30 ml/min this compensatory mechanism fails and hyperphosphatemia ensues. Pre-dialytic serum phosphate concentrations of >6 mg/dl increase cardiac mortality presumably to a large extent, but not exclusively, via promoting vascular calcification. It has recently been recognized that vascular calcification is not only a passive precipitation process following transgression of the critical Ca-×-P product, but is an active process accompanied by expression of osteoblastic bone markers in the vessel wall. Because of the recent recognition of the relation between vascular calcification and serum phosphate as well as serum calcium, there is a need for novel calcium-free phosphate binders. Currently sevelamer and lanthanum carbonate have been introduced and trivalent iron preparations are under development.
Optical MEMS devices based on moving waveguides

The paper deals with optical microelectromechanical systems (MEMS), and in particular with optical MEMS based on moving waveguides. After a short overview of this very attractive novel activity, specific technological problems and solutions are discussed. Then the following examples of recent developments based on silica on silicon technology are presented: optical switch, vibration sensor, and optical scanner.
Search, Obfuscation, and Price Elasticities on the Internet 1

We examine the competition between a group of Internet retailers who operate in an environment where a price search engine plays a dominant role. We show that for some products in this environment, the easy price search makes demand tremendously pricesensitive. Retailers, though, engage in obfuscation—practices that frustrate consumer search or make it less damaging to firms—resulting in much less price sensitivity on some other products. We discuss several models of obfuscation and examine its effects on demand and markups empirically.
Counterfactual thinking in patients with amnesia

We often engage in counterfactual (CF) thinking, which involves reflecting on “what might have been. ” Creating alternative versions of reality seems to have parallels with recollecting the past and imagining the future in requiring the simulation of internally generated models of complex events. Given that episodic memory and imagining the future are impaired in patients with hippocampal damage and amnesia, we wondered whether successful CF thinking also depends upon the integrity of the hippocampus. Here using two nonepisodic CF thinking tasks, we found that patients with bilateral hippocampal damage and amnesia performed comparably with matched controls. They could deconstruct reality, add in and recombine elements, change relations between temporal sequences of events, enabling them to determine plausible alternatives of complex episodes. A difference between the patients and control participants was evident, however, in the patients' subtle avoidance of CF simulations that required the construction of an internal spatial representation. Overall, our findings suggest that mental simulation in the form of nonepisodic CF thinking does not seem to depend upon the hippocampus unless there is the added requirement for construction of a coherent spatial scene within which to play out scenarios. © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
Coping strategies to manage acculturative stress: Meaningful activity participation, social support, and positive emotion among Korean immigrant adolescents in the USA

During acculturation, Asian immigrant adolescents have numerous challenges such as language barriers, cultural and ethnic differences, different school environments, discrimination experiences, and intergroup conflicts and tension. These challenges generate acculturative stress, which negatively affects the perception of health and well-being among Asian immigrant adolescents. This article explored how Asian immigrant adolescents perceive and cope with acculturative stress. In particular, this study examined the stress-coping strategies in the adaptation process as experienced by Korean immigrant adolescents. Three main themes associated with the stress-coping strategies were captured: (a) engagement in meaningful activities; (b) social support; and (c) positive emotion. This finding implies that Asian immigrant adolescents create and develop their own strategies to deal with acculturative stress, which results in a sense of happiness and psychological well-being. This study discuss the future implications on how to improve the perception of health and well-being among Asian immigrant adolescents.
Hepatitis A Antibody Seroprevalence in a Selected Kenyan Pediatric Population

The incidence of infection by Hepatitis A virus shows regional variation being highest in developing countries. Determination of age specific Hepatitis A virus (HAV) seroprevalence and the associated risk factors would help better plan for national preventive strategies including vaccination. We carried out a cross-sectional study on 300 children from Nairobi city, Kenya during the years 2003-2004. The age range of the children was 2 - 14 years and were from low and high socioeconomic status (SES) families. The indicators of SES included employment status, residence, number of children per patient’s household, parents’ level of education and source of drinking water. SES was encoded and analysed using Statistical Program for Social Sciences (SSPS) version 16.0. Seroprevalence increased significantly with advancing age. Seropositivity of HAV antibodies was significantly higher among children of low SES, 77.6% by the age of 14 years compared to children of high SES, 38.9% by the same age. Crowded household and parental education were significantly associated with high seropositivity and seronegativity respectively. There is significant rate of seronegativity amongst the studied population especially those from richer backgrounds making them more susceptible to severe infection in future with concomitant complications. We propose that revision of national vaccination program should be considered to include Hepatitis A vaccination.
Common genetic vulnerability for pathological gambling and alcohol dependence in men.

BACKGROUND In comparison with alcohol dependence (AD), relatively little is known about the causes of pathological gambling (PG). Given the high rate of comorbidity between PG and AD, knowledge about the causes of AD may be applied to understanding those of PG. METHODS Subjects were adult male twin pairs from the Vietnam Era Twin Registry. Lifetime histories of PG and AD were assessed by structured psychiatric telephone interview. The validity of a continuum of PG liability was tested to determine whether the causes of subclinical PG, or problem gambling, are quantitatively or qualitatively distinct from those of DSM-III-R PG disorder. Genetic model-fitting methods were used to quantify the extent to which the genetic and environmental risk for PG could be explained by the risk for AD. RESULTS Tests of the continuity model of PG were all consistent with the hypothesis that subclinical PG and DSM-III-R PG disorder have many, perhaps all, of the same risk factors and thus differ quantitatively rather than qualitatively. Depending on the PG definition, between 12% and 20% of the genetic variation and between 3% and 8% of the nonshared environmental variation in the risk for PG were accounted for by the risk for AD. CONCLUSIONS Subclinical PG, or problem gambling, may be a milder form of PG, rather than an etiologically distinct syndrome. Risk for AD accounts for a significant but modest proportion of the genetic and environmental risk for subclinical PG and DSM-III-R PG disorder.
Non-traditional control and advantages of multiphase AC inverter drives

The main advantage of multiphase frequency controlled AC drives is that they have more control resources than the 3-phase ones. The increase of the inverter system phase number (i.e. the number of the phases) more than five together with the joint application of the over-phase control method and the classical principle of AC motor frequency control in these systems allow to improve considerably a number of the drive technical-and-economic characteristics (speed of response, reliability, manufacturing cost, etc.).
The Conduct of Inquiry: Methodology for Behavioural Science

In arguably the finest text ever written in the philosophy of social science, Abraham Kaplan emphasizes what unites the behavioral sciences more than what distinguishes them from one another. Kaplan avoids the bitter disputes among people doing methodology, claiming instead that what is important are those qualities intrinsic to the overall aspirations of the social sciences. He deals with special problems of various disciplines only so far as may be helpful in clarifying the general method of inquiry. The Conduct of Inquiry is a systematic, rounded, and wide-ranging inquiry into behavioral science. Kaplan is guided by the experience of sciences with longer histories, but he is bound neither to their problems nor to their solutions. Instead, he addresses the methodology of behavioral science in the broad sense of both method and science. The work is not a formal exercise in the philosophy of science but rather a critical and constructive assessment of the developing standards and strategies of contemporary social inquiry. He emphasizes the tasks, achievements, limitations, and dilemmas of the newer disciplines. Philosophers of science usually choose to write about the most fully developed sciences because problems are clearer there. The result is ordinarily of little benefit to the behavioral scientist, whose task is clarification of method; here the precedents and analogies of physical science are obscure or inappropriate. The Conduct of Inquiry goes a long way in drawing upon the strengths of social research insights without simplifying the common concerns of the scientific enterprise as a whole. As Leonard Broom noted when the book initially appeared: "Kaplan fills a gap and does so with admirable clarity and often engaging wit. It lacks pomposity, pedantry, and pretension, and it is bound to make an impact on the teaching of and, with luck, research in the behavioral sciences. "
Suspicion Modeling in Support of Cyber-Influence Operations/Tactics

Abstract : Understanding the cognitive process of IT user suspicion may assist organizations in development of network protection plans, personnel training, and tools necessary to identify and mitigate nefarious intrusions of IT systems. Exploration of a conceptual common ground between pycho-social and technology-related concepts of suspicion are the heart of this investigation. The complexities involved in merging these perspectives led to the overall research question: What is the nature of user suspicion toward IT: The research problem/phenomenon was addressed via extensive literature review, and use of the Interactive Qualitative Analysis problem/phenomenon. Analysis of the system led to the development of a model of IT suspicion as a progenitor for future experimental constructs that measure or assess behavior as a result of cyber attacks.
"Pro-Ana" Web-Log Uses and Gratifications towards Understanding the Pro-Anorexia Paradox

Eating disorders have the highest mortality rate of all mental illnesses. Currently, web-logs are hosts to thousands of pro-ana (short for pro-anorexia) blogring participants, joining together with a common claim that eating disorders are lifestyles not illnesses.  This study explored participation motives among pro-ana blogring participants, relationships to individual psycho-social factors, and to unique web-log features. Results from the cross-sectional online survey suggest three main participation motives among blogring participants (community, obtaining social/ emotional support, and egoprotection. Results also indicate individual factors such as; social support satisfaction, drive-for-thinness, and BMI were related to blogger motives in a various diverse ways. Analyses of the findings from the present study reflect the self-disclosive nature of the blogging process. The results have several implications for eating disorder, computermediated communication, internet social support, and blog/blogring research.
Deep Learning for Event-Driven Stock Prediction

We propose a deep learning method for event-driven stock market prediction. First, events are extracted from news text, and represented as dense vectors, trained using a novel neural tensor network. Second, a deep convolutional neural network is used to model both short-term and long-term influences of events on stock price movements. Experimental results show that our model can achieve nearly 6% improvements on S&P 500 index prediction and individual stock prediction, respectively, compared to state-of-the-art baseline methods. In addition, market simulation results show that our system is more capable of making profits than previously reported systems trained on S&P 500 stock historical data.
Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells into Insulin-Producing Cells: Evidence for Further Maturation In Vivo

The aim of this study was to provide evidence for further in vivo maturation of insulin-producing cells (IPCs) derived from human bone marrow-derived mesenchymal stem cells (HBM-MSCs). HBM-MSCs were obtained from three insulin-dependent type 2 diabetic volunteers. Following expansion, cells were differentiated according to a trichostatin-A/GLP protocol. One million cells were transplanted under the renal capsule of 29 diabetic nude mice. Blood glucose, serum human insulin and c-peptide levels, and glucose tolerance curves were determined. Mice were euthanized 1, 2, 4, or 12 weeks after transplantation. IPC-bearing kidneys were immunolabeled, number of IPCs was counted, and expression of relevant genes was determined. At the end of in vitro differentiation, all pancreatic endocrine genes were expressed, albeit at very low values. The percentage of IPCs among transplanted cells was small (≤3%). Diabetic animals became euglycemic 8 ± 3 days after transplantation. Thereafter, the percentage of IPCs reached a mean of ~18% at 4 weeks. Relative gene expression of insulin, glucagon, and somatostatin showed a parallel increase. The ability of the transplanted cells to induce euglycemia was due to their further maturation in the favorable in vivo microenvironment. Elucidation of the exact mechanism(s) involved requires further investigation.
Blind Search for Atari-Like Online Planning Revisited

Similarly to the classical AI planning, the Atari 2600 games supported in the Arcade Learning Environment all feature a fully observable (RAM) state and actions that have deterministic effect. At the same time, the problems in ALE are given only implicitly, via a simulator, a priori precluding exploiting most of the modern classical planning techniques. Despite that, Lipovetzky et al. [2015] recently showed how online planning for Atari-like problems can be effectively addressed using IW(i), a blind state-space search algorithm that employs a certain form of structural similarity-based pruning. We show that the effectiveness of the blind state-space search for Atari-like online planning can be pushed even further by focusing the search using both structural state similarity and the relative myopic value of the states. We also show that the planning effectiveness can be further improved by considering online planning for the Atari games as a multiarmed bandit style competition between the various actions available at the state planned for, and not purely as a classical planning style action sequence optimization problem.
Association of depression and anxiety disorders with weight change in a prospective community-based study of children followed up into adulthood.

OBJECTIVE To investigate childhood to adulthood weight change associated with anxiety and depression. DESIGN The Children in the Community Study. A prospective longitudinal investigation. SETTING Albany and Saratoga Counties, New York. PARTICIPANTS Eight hundred twenty individuals (403 females and 417 males) assessed at 4 time points: in 1983 when they were 9 to 18 years old (n = 776), in 1985 to 1986 when they were 11 to 22 years old (n = 775), in 1991 to 1994 when they were 17 to 28 years old (n = 776), and in 2001 to 2003 when they were 28 to 40 years old (n = 661). MAIN EXPOSURES Anxiety disorders and depression assessed by structured diagnostic interview. MAIN OUTCOME MEASURES Centers for Disease Control and Prevention body mass index z score (BMIz), a measure of weight status; and association of anxiety and depression with BMIz level and annual change. RESULTS In females, anxiety disorders were associated with higher weight status, a BMIz of 0.13 (95% confidence interval, 0.01-0.25) units higher compared with females without anxiety disorders. Female depression was associated with a gain in BMIz of 0.09 units/y (95% confidence interval, 0.03-0.15 units/y), modified by the age when depression was first observed, such that early depression onset was associated with a higher subsequent BMIz than depression onset at older ages. In males, childhood depression was associated with a lower BMIz (-0.46; 95% confidence interval, -0.93 to 0.02 units lower at the age of 9 years), but BMIz trajectories for males with or without depression converged in adulthood; male anxiety disorders were not substantively associated with weight status. CONCLUSIONS Anxiety disorders and depression were associated with a higher BMIz in females, whereas these disorders in males were not associated with a higher BMIz. These results, if causal and confirmed in other prospective studies, support treating female anxiety and depression as part of comprehensive obesity prevention efforts.
Lix and Rix: Variations on a Little-Known Readability Index.

or Lix for short (Bjbrnsson, 1968), and has been extensively trialled. The lack of reading information on Lix is probably because its development was reported in Swedish. It has not been discussed in any of the major recent readability reviews (Gilliland, 1972; Harrison, 1980; Klare, 1974). However, after I reported the application of Lix to French, German, Greek, and English texts (Anderson, 1981) the response from classroom teachers was such that I conducted a more
Creating ensembles of classifiers

Ensembles of classifiers offer promise in increasing overall classification accuracy. The availability of extremely large datasets has opened avenues for application of distributed and/or parallel learning to efficiently learn models of them. In this paper, distributed learning is done by training classifiers on disjoint subsets of the data. We examine a random partitioning method to create disjoint subsets and propose a more intelligent way of partitioning into disjoint subsets using clustering. It was observed that the intelligent method of partitioning generally performs better than random partitioning for our datasets. In both methods a significant gain in accuracy may be obtained by applying bagging to each of the disjoint subsets, creating multiple diverse classifiers. The significance of our finding is that a partition strategy for even small/moderate sized datasets when combined with bagging can yield better performance than applying a single learner using the entire dataset.
Eccrine Sweat Duct Occlusion by Staphylococcal-Derived Biofilms: An Unexpected Signature Finding of Eczema in Dermatologic Diseases

We believe that axillary granular parakeratosis, tinea pedis, and Seborrheic dermatitis are likely to be variants of eczema. All had culturable staphylococci capable of producing biofilms, as in eczema. This was confirmed on XTT assays, Congo red cultures, and PCR for gene analysis of the biofilm-forming icaD and aap genes. The pathology showed eccrine ductal occlusion that was noted on H+E and PAS stains (PAS stains positively the extracellular polysaccharide substance that makes up the bulk of the biofilm.) Toll-like receptor 2 (TLR 2) activities was found in the stratum corneum adjacent to the sweat ducts and not in its control location in the basal zone. The stratum corneum seemingly becomes altered by the fungi, yeasts, or tiny granules instead of by the filaggrin gene (1st in the double hit phenomenon); and, the sweat ducts become occluded causing activation of TLR 2. This leads to activation of the innate immune system (2nd hit), just as in eczema. Further, treatment with the mild topical corticoids and/or moisturizers helps restore the integrity of the skin.