Miracle-dz/UniFAR-FTUs huggingface dataset:
UNMASKING VANDALISM: A CASE OF SOCIAL JUSTICE LEADERSHIP COMPLEXITIES

Waterfront Elementary School is located in a very affluent neighbourhood in a large urban multicultural school district. The school has some diversity in terms of its student population, but the majority of the students are White and come from upper middle-class families. Ms. Courtney Williams, the principal of the school was transferred to Waterfront Elementary School five years ago due to her expertise in the area of assessment and evaluation. Since her arrival, she has been applauded by the school community and school district for her knowledge and dedication to students’ academic success. This case highlights the tensions, challenges, and struggles that she faces when she is confronted by upset and angry parents with regard to a vandalism incident in her school that could have far-reaching implications for her, her school, the district, and the wider community.
Celastrol Suppresses Tumor Cell Growth through Targeting an AR-ERG-NF-κB Pathway in TMPRSS2/ERG Fusion Gene Expressing Prostate Cancer

The TMPRSS2/ERG (T/E) fusion gene is present in the majority of all prostate cancers (PCa). We have shown previously that NF-kB signaling is highly activated in these T/E fusion expressing cells via phosphorylation of NF-kB p65 Ser536 (p536). We therefore hypothesize that targeting NF-kB signaling may be an efficacious approach for the subgroup of PCas that carry T/E fusions. Celastrol is a well known NF-kB inhibitor, and thus may inhibit T/E fusion expressing PCa cell growth. We therefore evaluated Celastrol’s effects in vitro and in vivo in VCaP cells, which express the T/E fusion gene. VCaP cells were treated with different concentrations of Celastrol and growth inhibition and target expression were evaluated. To test its ability to inhibit growth in vivo, 0.5 mg/kg Celastrol was used to treat mice bearing subcutaneous VCaP xenograft tumors. Our results show Celastrol can significantly inhibit the growth of T/E fusion expressing PCa cells both in vitro and in vivo through targeting three critical signaling pathways: AR, ERG and NF-kB in these cells. When mice received 0.5 mg/kg Celastrol for 4 times/week, significant growth inhibition was seen with no obvious toxicity or significant weight loss. Therefore, Celastrol is a promising candidate drug for T/E fusion expressing PCa. Our findings provide a novel strategy for the targeted therapy which may benefit the more than half of PCa patients who have T/E fusion expressing PCas.
Growth rate-dependent control of chromosome replication initiation in Escherichia coli

The initiation mass, defined as cell mass per origin of deoxyribonucleic acid replication (optical density units at 460 nm of culture/origins per milliliter of culture), reflects the intracellular concentration or activity of a hypothetical factor that controls initiation of chromosome replication in bacteria. In Escherichia coli B/r, the initiation mass was found to increase about twofold with increasing growth rate between 0.6 and 1.6 doublings per h; at higher growth rates it remained essentially constant (measured up to 2.4 doublings per h). A low-thymine-requiring (thyA deoB) derivative of E. coli B/r, strain TJK16, was found to have a 60 to 80% greater initiation mass than B/r which was independent of the replication velocity and not related to the thyA and deoB mutations. It is suggested that TJK16 had acquired, during its isolation, a mutation in a gene affecting the initiation of deoxyribonucleic acid replication. The initiation age was not altered by this mutation, but other parameters, including deoxyribonucleic acid concentration and cell size, were changed in comparison with the B/r parent, as expected from theoretical considerations.
Heat Acclimation by Postexercise Hot-Water Immersion: Reduction of Thermal Strain During Morning and Afternoon Exercise-Heat Stress After Morning Hot-Water Immersion.

PURPOSE Recommendations state that to acquire the greatest benefit from heat-acclimation, the clock time of heat-acclimation sessions should match that of expected exercise-heat stress. It remains unknown if adaptations by postexercise hot-water immersion (HWI) demonstrate time-of-day-dependent adaptations. Thus, the authors examined whether adaptations following postexercise HWI completed in the morning were present during morning and afternoon exercise-heat stress. METHODS Ten males completed an exercise-heat stress test commencing in the morning (9:45 AM) and afternoon (2:45 PM; 40 min; 65% of maximal oxygen uptake treadmill run) before and after heat-acclimation. The 6-d heat-acclimation intervention involved a daily 40-min treadmill run (65% of maximal oxygen uptake) in temperate conditions followed by ≤40-min HWI (40°C; 6:30-11:00 AM). RESULTS Adaptations by 6-d postexercise HWI in the morning were similar in the morning and afternoon. Reductions in resting rectal temperature (Tre) (AM -0.34°C [0.24°C], PM -0.27°C [0.23°C]; P = .002), Tre at sweating onset (AM -0.34°C [0.24°C], PM -0.31°C [0.25°C]; P = .001), and end-exercise Tre (AM -0.47°C [0.33°C], PM -0.43°C [0.29°C]; P = .001), heart rate (AM -14 [7] beats·min-1, PM -13 [6] beats·min-1; P < .01), rating of perceived exertion (P = .01), and thermal sensation (P = .005) were not different in the morning compared with the afternoon. CONCLUSION Morning heat acclimation by postexercise HWI induced adaptations at rest and during exercise-heat stress in the morning and midafternoon.
Miconazole-Urea in a Buccal Film as a New Trend for Treatment of Resistant Mouth Fungal White Patches

A growing concern about Candida albicans is the emergence of high incidence of resistance against antifungal agents, which requires searching for new medications or improving the response to the existing members. The objective of this work was to evaluate the effectiveness of the miconazole in the absence and presence of urea, as a penetration enhancer, against C. albicans. In addition to, formulating both of them in a polymer film to be used topically for treatment of mouth fungal white patches caused by C. albicans. A synergistic effect was recorded between this imidazole and urea against the test strain. Miconazole MIC (32 mg/L) was dramatically reduced to 0.0625 mg/L following combination with urea. Transmission electron microscopy explained the mechanisms of action mediated by the test agents. Minimal fungicidal dose of miconazole combined with urea showed early apoptotic cells with condensed chromatin and small blebs. Cytoplasmic leakage and necrosis in some cells was observed at high fungicidal dose. Buccal bioadhesive films were prepared using increasing values of the drug MIC and urea. The physicochemical characters of the prepared films including; film weight, thickness, swelling index, drug content, folding endurance, surface pH, bioadhesion force and time and drug release kinetics, were studied. Microbiological evaluation of all prepared films showed an increase in the inhibition zone diameters for films containing increasing concentrations of both miconazole and urea in a concentration-dependent manner (30–40 mm) compared to miconazole alone (18 mm). Based on our results, the prepared films are promising for buccal administration of miconazole/urea showing synergistic effect for treatment of C. albicans infection.
HER2-Targeted Antibody Treatment for Ovarian Cancer Future Opportunities

There are an estimated 240,000 new cases of ovarian cancer diagnosed worldwide each year [1]. Due to late presentation, in many parts of the world it remains the most lethal gynecological cancer [2]. In 2004, a new model description of this disease was proposed that combined both histopathological and molecular features and which classified epithelial ovarian cancers into two broad categories designated Type I and Type II tumors [3].
Neuroprotective effects of Foeniculum vulgare seeds extract on lead-induced neurotoxicity in mice brain

Abstract The present study investigates the neuroprotective effects of Foeniculum vulgare seeds in a lead (Pb)-induced brain neurotoxicity mice model. The dried seeds extract of Foeniculum vulgare was prepared with different concentrations of organic solvents (ethanol, methanol, n-hexane). The in vitro antioxidant activity of Foeniculum vulgare seed extracts was assessed through DPPH assay and the chemical composition of the extracts was determined by high-resolution 1H NMR spectroscopy. The age-matched male Balb/c mice (divided into 9 groups) were administered with 0.1% Pb and 75% and 100% ethanol extracts of Foeniculum vulgare seeds at a dose of 200 mg/kg/day and 20 mg/kg/day. The maximum antioxidant activity was found for 75% ethanol extract, followed by 100% ethanol extract. Gene expression levels of oxidative stress markers (SOD1 and Prdx6) and the three isoforms of APP (APP common, 770 and 695), in the cortex and hippocampus of the treated and the control groups were measured. Significant increase in APP 770 expression level while a substantial decrease was observed for SOD1, Prdx6 and APP 695 expression in Pb-treated groups. Interestingly, the deranged expression levels were significantly normalized by the treatment with ethanol extracts of Foeniculum vulgare seeds (specifically at dose of 200 mg/kg/day). Furthermore, the Pb-induced morphological deterioration of cortical neurons was significantly improved by the ethanol extracts of Foeniculum vulgare seeds. In conclusion, the present findings highlight the promising therapeutic potential of Foeniculum vulgare to minimize neuronal toxicity by normalizing the expression levels of APP isoforms and oxidative stress markers.
The dimensions and effects of excessive change

Purpose – Change excessiveness is argued as a critical contextual aspect of change management. The purpose of this paper is to identify three major dimensions to change excessiveness: change frequency, extent, and impact. A three-factor structure is proposed to broaden the emerging study on the contextual aspects of change. Its pertinence is proposed in addressing healthcare employees’ exhaustion, change-related uncertainty, and support for change. Design/methodology/approach – Using questionnaires, a first pilot sample (n=131) was recruited to test the psychometric properties and validity of the three-factor structure, while controlling for affectivity. Structural equation modeling techniques following a two-step approach were used on a second sample (n=363). First a confirmatory assessment of the three-factor structure of excessive change is tested. Second, a full mediation effect of excessive change, as a second-order latent factor, regrouping change frequency, impact and extent as first-order factors, was modeled to predict a tripartite conception of change-related reactions: exhaustion, uncertainty, and support for change. Findings – The excessive change three-factor structure is validated, while showing its superiority over alternative models. The fully mediated model is confirmed. Therefore, the significant added effects of change frequency, impact, and extent are positively related to emotional exhaustion and cognitive uncertainty, while negatively related with behavioral support for change. Originality/value – This study contributes by proposing a three-factor structure to excessive change assessment based on previous and independent findings in the literature. It also contributes in modeling the added effect of change frequency, extent, and impact in the full mediation relationship of change excessiveness on a tripartite reactions to change in healthcare management settings.
A Degeneracy Framework for Graph Similarity

The problem of accurately measuring the similarity between graphs is at the core of many applications in a variety of disciplines. Most existing methods for graph similarity focus either on local or on global properties of graphs. However, even if graphs seem very similar from a local or a global perspective, they may exhibit different structure at different scales. In this paper, we present a general framework for graph similarity which takes into account structure at multiple different scales. The proposed framework capitalizes on the well-known k-core decomposition of graphs in order to build a hierarchy of nested subgraphs. We apply the framework to derive variants of four graph kernels, namely graphlet kernel, shortest-path kernel, Weisfeiler-Lehman subtree kernel, and pyramid match graph kernel. The framework is not limited to graph kernels, but can be applied to any graph comparison algorithm. The proposed framework is evaluated on several benchmark datasets for graph classification. In most cases, the core-based kernels achieve significant improvements in terms of classification accuracy over the base kernels, while their time complexity remains very attractive.
Intriguing association of Parkinson's disease and epileptic seizures

We read with interest the article by Gruntz et al. These authors suggest that incident Parkinson's disease (PD) is associated with an increased risk of incident epileptic seizures. This observation is a very important contribution, which will be useful in future studies, and we want to acknowledge these authors for their efforts. However, some issues raise concerns and merit a more detailed examination. First, Gruntz et al’s case selection is based on a large data set from a primary care setting. The same group, using the same data set in previous articles, specified that only a small percentage (1%) of all cases were referred to a neurologist to confirm the diagnosis, and that seizure diagnosis is not formally validated in the data set. Other disorders with prominent signs and symptoms of transient loss of consciousness (TLOC), such as syncope, may be confused with seizures. The reliability of the diagnosis of the first TLOC is therefore surprisingly low, and this may particularly be the case in a primary care setting, such as the one used for this study. Second, for case selection, one of the engaged criteria was usage of antiepileptic drugs (AEDs) in combination with diagnostic codes indicating a suspected epileptic seizure as a surrogate for the diagnosis of epileptic seizure. However, AEDs can be indicated for many conditions other than epilepsy, which may lead to misclassification. In a sensitivity analysis, these authors applied a definition of incident epilepsy that they used in another study with the same data set. However, that study used criteria of AED prescriptions in conjunction with diagnostic codes for epilepsy and not with codes for suspected epileptic seizures. Finally, this study utilized a conditional logistic regression analyses to explore the “real association” between PD and the risk of epileptic seizures. Nevertheless, these authors essentially presented only the results of a univariate logistic regression. A univariate analysis should be only the first step in any model building process. Despite the fact that this study matched controls for many variables, there can still be effect modifiers, and a multivariate analysis could examine potential statistical interactions between each of the selected variables. Overall, the association of PD and epileptic seizures is intriguing, and we strongly support further investigation in this area. However, considerable caution is necessary in making causal inferences from case‐control studies.
Childhood obesity and eating behaviour

Abstract The prevalence of childhood obesity has increased substantially in the recent decade as a result of the reduction in physical activity and the availability of high-fat and high-energy-density foods which the paediatric population faces daily. Although children are highly exposed to these foods, there is a wide variation in body weight, suggesting the presence of different patterns of response to an “obesogenic” environment. This wide variability from the point of view of eating behaviour involves a number of social issues (e.g., food availability, cost) as well as genuine behavioural traits such as the response to satiety, energy compensation, eating rate, responsiveness to food, food reward and dietary preferences. This article reviews the main physiological variables related to energy intake affecting eating behaviour in the paediatric population.
AMISH EYE STUDY: Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration.

PURPOSE To describe spectral domain optical coherence tomography (SD-OCT) findings in an Amish cohort to assess SD-OCT markers for early age-related macular degeneration (AMD). METHODS The authors performed a family-based prospective cohort study of 1,146 elderly Amish subjects (age range 50-99 years) (2,292 eyes) who had a family history of at least 1 individual with AMD. All subjects underwent complete ophthalmic examinations, SD-OCT using both Cirrus and Spectralis (20 × 20° scan area) instruments, fundus autofluorescence, infrared imaging, and color fundus photography. Spectral domain optical coherence tomography characteristics were analyzed in subjects with AMD (with and without subretinal drusenoid deposits [SDDs]) and normal healthy cohorts. RESULTS Participants' mean age was 65.2 years (SD ± 11). Color fundus photographic findings in 596 (53%) subjects (1,009 eyes) were consistent with AMD; the remaining 478 (43%) subjects showed no signs of AMD. The choroid was significantly thinner on OCT (242 ± 76 µm, P < 0.001) in those with AMD compared with those without (263 ± 63 µm). Subretinal drusenoid deposits were found in 143 eyes (7%); 11 of the 143 eyes (8%) had no other manifestations of AMD. Drusen volume (P < 0.001) and area of geographic atrophy (P < 0.001) were significantly greater, and choroid was significantly (P < 0.001) thinner in subjects with SDDs versus those without SDDs. CONCLUSION The authors describe spectral domain optical coherence tomography characteristics in an elderly Amish population with and without AMD, including the frequency of SDD. Although relatively uncommon in this population, the authors confirmed that SDDs can be found in the absence of other features of AMD and that eyes with SDDs have thinner choroids.
EcoEvo-MAPS: An Ecology and Evolution Assessment for Introductory through Advanced Undergraduates

A new assessment tool, Ecology and Evolution–Measuring Achievement and Progression in Science or EcoEvo-MAPS, measures student thinking in ecology and evolution during an undergraduate course of study. EcoEvo-MAPS targets foundational concepts in ecology and evolution and uses a novel approach that asks students to evaluate a series of predictions, conclusions, or interpretations as likely or unlikely to be true given a specific scenario. We collected evidence of validity and reliability for EcoEvo-MAPS through an iterative process of faculty review, student interviews, and analyses of assessment data from more than 3000 students at 34 associate’s-, bachelor’s-, master’s-, and doctoral-granting institutions. The 63 likely/unlikely statements range in difficulty and target student understanding of key concepts aligned with the Vision and Change report. This assessment provides departments with a tool to measure student thinking at different time points in the curriculum and provides data that can be used to inform curricular and instructional modifications.
Ventilatory control sensitivity in patients with obstructive sleep apnea is sleep stage dependent

Study Objectives The severity of obstructive sleep apnea (OSA) is known to vary according to sleep stage; however, the pathophysiology responsible for this robust observation is incompletely understood. The objective of the present work was to examine how ventilatory control system sensitivity (i.e. loop gain) varies during sleep in patients with OSA. Methods Loop gain was estimated using signals collected from standard diagnostic polysomnographic recordings performed in 44 patients with OSA. Loop gain measurements associated with nonrapid eye movement (NREM) stage 2 (N2), stage 3 (N3), and REM sleep were calculated and compared. The sleep period was also split into three equal duration tertiles to investigate how loop gain changes over the course of sleep. Results Loop gain was significantly lower (i.e. ventilatory control more stable) in REM (Mean ± SEM: 0.51 ± 0.04) compared with N2 sleep (0.63 ± 0.04; p = 0.001). Differences in loop gain between REM and N3 (p = 0.095), and N2 and N3 (p = 0.247) sleep were not significant. Furthermore, N2 loop gain was significantly lower in the first third (0.57 ± 0.03) of the sleep period compared with later second (0.64 ± 0.03, p = 0.012) and third (0.64 ± 0.03, p = 0.015) tertiles. REM loop gain also tended to increase across the night; however, this trend was not statistically significant [F(2, 12) = 3.49, p = 0.09]. Conclusions These data suggest that loop gain varies between REM and NREM sleep and modestly increases over the course of sleep. Lower loop gain in REM is unlikely to contribute to the worsened OSA severity typically observed in REM sleep, but may explain the reduced propensity for central sleep apnea in this sleep stage.
Risk factors of Oral cancer- A hospital based case control study

Background Oral cancer is a highly prevalent malignancy in Pakistan. Among various risk factors associated with this neoplasm, habits such as smoked and smokeless tobacco usage, betel quid, and betel nut consumption are the major culprits in our society. In the present study, we aimed to ascertain prevalent risk factors for OC in our population and to compare our findings with healthy controls to establish their significance. Material and Methods A hospital-based case control study was conducted at Dow University of Health Sciences, Pakistan from January 2015 – September 2016. Information pertaining to unhealthy oral habits was obtained from 62 oral cancer patients (cases) and 62 healthy controls on specifically designed proforma by the principal investigator. Results Smokeless tobacco is strong, independent risk factor for oral cancer development in our study population. Buccal mucosa is the predominantly affected site (71%) which corresponds with high smokeless tobacco use. All studied habits increase risk of oral cancer as demonstrated by high odds ratio. Conclusions Despite advancement in our knowledge and understanding of carcinogenic potential of these hazardous substances not enough efforts have been put forth to effectively control their widespread sale and consumption, particularly by the youth in our society. Key words:Betel Quid, Gutka, Oral Cancer Risk, Smokeless Tobacco.
The role of errorful and errorless training on error detection and learning of tracking task

The aim of this study is to investigate errorful and errorless training methods on detecting error in tracking task. 24 students of Allameh Tabataba'i University (Age = 23± 2.8 yrs.) were randomly selected to perform a computerized tracking test. The participants underwent a pre-test after being given verbal instructions and were divided into two groups of errorful and errorless training according to the test results. The errorless training group, during task performance, saw the target path and the path they were tracking as a diagram and detected errors according to the difference between the two paths. But the errorful training group attained the task goal by trial-and-error. Each group underwent 30 tests in 3 seperate sessions with a recovery period of 24 h in-between. The results showed the significant effect of errorful and errorless training on the progress of detecting errors in acquisition and retention stages of tracking task. Furthermore, a significant difference has been identified between the effects of errorful and errorless training methods on the acquisition and retention of tracking task. This difference was in favor of the errorless training group and this group's progress in detecting errors was more than the errorful training group. The results showed that in addition to the influence of errorful and errorless training methods on detecting error in tracking task, there is a difference between the effect of these methods in detecting error and the errorless training method has a more positive effect on participants' error detecting ability in the tracking task.