Miracle-dz/UniFAR-FTUs huggingface dataset:
Similar Hormonal Stress and Tissue Damage in Response to National Collegiate Athletic Association Division I Football Games Played in Two Consecutive Seasons

Abstract Sterczala, AJ, Flanagan, SD, Looney, DP, Hooper, DR, Szivak, TK, Comstock, BA, DuPont, WH, Martin, GJ, Volek, JS, Maresh, CM, and Kraemer, WJ. Similar hormonal stress and tissue damage in response to National Collegiate Athletic Association Division I football games played in two consecutive seasons. J Strength Cond Res 28(11): 3239–3243, 2014—The recovery process from a college football game has been studied, yet the stability of such findings year to year in the same players remains unclear. The purpose of this study was to examine the same players' biochemical recovery process in 2 consecutive seasons to a National Collegiate Athletic Association (NCAA) Division I football game. Ten starting players volunteered to participate in the study in each of the 2 seasons. Players performed a periodized heavy resistance training program over the entire year for each season. Fasted resting blood samples were obtained at similar times the Friday before the game (T1), 18–20 hours after the game (T2), and 42–44 hours after the game (T3). In both seasons, serum creatine kinase (CK) concentrations increased significantly from T1 to T2, and returned to T1 values at T3. When we compared seasons, CK values did not differ at any time point. Myoglobin demonstrated similar patterns and results. Testosterone and cortisol values were similar at all time points and did not differ by season as no significant differences were observed for the resting hormonal concentrations. The results of this study indicate that yearly programs should maintain a periodized progressive program, which seeks to increase physical potential of players while providing a protective effect on skeletal muscle and stabilization of hormonal status in response to both game and season stressors.
Palliative treatment of patients with inoperable locally advanced, recurrent or metastatic head and neck squamous cell cancer, using a low-dose and personalized chemotherapeutic regimen

Inoperable or metastatic head and neck squamous cell cancer (HNSCC) is known to be associated with a poor patient prognosis. First line therapies include a Taxol, platinum-based antineoplastic and fluorouracil (FU) treatment regimen (TPF) or a platinum-based antineoplastic, FU and EGFR inhibitor treatment regimen (PFE). The toxicity of these regimens is one of the major limiting factors, particularly for palliative treatment. The present study is a retrospective study of 15 patients with HNSCC, where the treatment goal was palliative. Of the 15 patients, 8 received a TPF, while 7 received a PFE. A total of 129 treatment cycles were administered with a median of 9 cycles (range, 3–14). Chemotherapy began with low doses and was subsequently titrated up based on tolerance and response. Positive responses were noted with the lower doses compared with the conventional doses, and maximal doses were not required. The median dose of cisplatin, paclitaxel and 5-FU administered was 40 mg/m2, 80 mg/m2 and 360 mg/m2/day for 5 days, respectively. Cetuximab was used at a standard dose. At the initial follow-up (mean, 64 days; 3 cycles), a 100% disease control rate (DCR) and 80% overall response rate (ORR) was achieved. A positive response, 60% DCR and 60% ORR, was maintained until the late stages of the study (mean, 217 days; 9 cycles). Following termination of chemotherapy after >9 cycles, 4 patients remained disease free for ~1 year. A total of 3 patients exhibited a pathologic complete response despite radiologically exhibiting residual disease. The median progression-free survival time was 10.03 months and the overall survival time was 15.77 months. The only grade 3 hematologic toxicity noted was neutropenia in 3 (20%) patients. Grade 3 vomiting was noted in 1 (6.67%) patient and grade 3 stomatitis was noted in 1 (6.67%) patient. Due to low toxicity patients exhibited improved tolerance to this approach, particularly in terms of palliative care. Furthermore, these results are in contrast to the axiom that increased doses are more effective.
Prolonged Perceptual Learning of Positional Acuity in Adult Amblyopia: Perceptual Template Retuning Dynamics

Amblyopia is a developmental abnormality that results in physiological alterations in the visual cortex and impairs form vision. It is often successfully treated by patching the sound eye in infants and young children, but is generally considered to be untreatable in adults. However, a number of recent studies suggest that repetitive practice of a visual task using the amblyopic eye results in improved performance in both children and adults with amblyopia. These perceptual learning studies have used relatively brief periods of practice; however, clinical studies have shown that the time-constant for successful patching is long. The time-constant for perceptual learning in amblyopia is still unknown. Here we show that the time-constant for perceptual learning depends on the degree of amblyopia. Severe amblyopia requires >50 h (≈35,000 trials) to reach plateau, yielding as much as a five-fold improvement in performance at a rate of ≈1.5%/h. There is significant transfer of learning from the amblyopic to the dominant eye, suggesting that the learning reflects alterations in higher decision stages of processing. Using a reverse correlation technique, we document, for the first time, a dynamic retuning of the amblyopic perceptual decision template and a substantial reduction in internal spatial distortion. These results show that the mature amblyopic brain is surprisingly malleable, and point to more intensive treatment methods for amblyopia.
A Comparison in Hospitalization Rates Between a Community-Based Mobile Emergency Service and a Hospital-Based Emergency Service

Objectives: The aims of this study were to compare the rates of inpatient admission between a mobile community-based psychiatric emergency service and a hospital-based psychiatric emergency service, and to identify the clinical characteristics of consumers more likely to be admitted to hospital. Methods: A retrospective, quasi-experimental design was used with a 3-month cohort of all face-to-face emergency service contacts presenting at the mobile and hospital-based sites. The Health of the Nation Outcome Scales and details of the outcome following initial assessment were completed for all contacts, and each group was compared for differences in clinical characteristics and outcome. Results: Hospital-based emergency service contacts were found to be more than three times as likely to be admitted to a psychiatric inpatient unit when compared with those using a mobile community-based emergency service, regardless of their clinical characteristics. Those with severe mental health disorders such as schizophrenia and major affective disorder, and experiencing problems with aggression, non-accidental self-injury, hallucinations and delusions, problems with occupation, activities of daily living, and living conditions were more likely to be admitted to hospital. Nevertheless, after controlling for clinical characteristics, site of initial assessment accounted for a substantial proportion of the variance in decisions to admit to hospital. Conclusions: Emergency psychiatric services which include a mobile component and provide a specialized multidisciplinary team approach appear to be most effective in providing services in the least restrictive environment and avoiding hospitalization.
The effect of fluoride on the structure, function, and proteome of a renal epithelial cell monolayer

High concentrations of fluoride in the body may cause toxic effects. Here, we investigated the effects of fluoride on the structure, function, and proteome of a cortical collecting duct epithelium in vitro. Kidney tubule cells (M‐1) were chosen because the concentration of fluoride in the kidney is 4–5‐fold higher than that in plasma. Mouse M‐1 cell monolayers were incubated in fluoride‐containing media, and the amiloride‐sensitive short‐circuit current and transepithelial resistance were measured. The Young's modulus of the epithelium was determined using atomic force microscopy, and the effect of fluoride on epithelial structure was assessed using scanning and transmission electron microscopy, and immunofluorescence. Differences in the expression of membrane proteins were evaluated using proteomics and bioinformatics. Fluoride exposure reduced both transepithelial Na+ transport and resistance. The IC50 for fluoride was ∼300 µM for both effects, and the half‐times for the decays of ion transport and resistance were 8.4 h and 3.6 days, respectively. Fluoride treatment did not affect the sensitivity of Na+ transport to amiloride. The Young's modulus of the epithelium was also unaffected by fluoride; however, the functional effects of fluoride were accompanied by marked structural effects. Proteomic analysis revealed changes in expression of a number of proteins, and particularly mitochondrial proteins. Treatment with fluoride had profound effects on the structure, function and proteome of a model cortical collecting duct epithelium. Significantly, however, these effects were produced only at concentrations considerably higher than those likely to be encountered in vivo. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1455–1467, 2017.
Children and adolescents' interpretations of peer based social exclusion

Title of dissertation: CHILDREN AND ADOLESCENTS’ INTERPRETATIONS OF PEER BASED SOCIAL EXCLUSION Shelby Patricia Cooley, Doctor of Philosophy, 2015 Dissertation directed by: Professor Melanie Killen, Department of Human Development Developmental research on intergroup attitudes has identified social exclusion as a complex peer interaction that can often reflect stereotypes and bias (Killen, Mulvey, & Hitti, 2013). Given the complexity of interracial peer encounters, it is necessary to understand the conditions and contexts in which interracial social exclusion occurs and how racial minority and majority children evaluate such types of interactions. The current study investigated African American and European American children and adolescent’s evaluations of peer encounters manipulating three factors: 1) the racial composition of the peers involved (interracial vs. same-race), 2) the source of the message (messages from peers vs. parents), and 3) the form of the message (overt vs. covert). Four child-level variables were examined and included: participant race, age, level of interracial contact, and racial identity. European American participants, particularly adolescents, viewed same-race inclusion as more likely than interracial and evaluated exclusion in both contexts to be just as wrong. In contrast, African American participants viewed interracial and same-race inclusion to be just as likely, but evaluated exclusion to be more wrong in interracial than same-race contexts. With age, children viewed interracial social inclusion as less likely and even more so when interactions involved messages from parents. Interracial contact and racial identity were found to be critical features that contributed to expectations for interracial inclusion occurring in peer encounters. The findings are discussed with respect to peer and parental messages about interracial peer encounters and the conditions that are necessary for prejudice reduction. CHILDREN AND ADOLESCENTS’ INTERPRETATIONS OF PEER BASED SOCIAL EXCLUSION by Shelby Patricia Cooley Dissertation submitted to the faculty of the Graduate School of the University of Maryland, College Park, in fulfillment of the requirement of the degree of Doctor of Philosophy 2015 Advisory Committee: Professor Melanie Killen, Chair Associate Professor Natasha Cabrera Associate Professor Kimberly Griffin Associate Professor Geetha Ramani Professor Adam Rutland Professor Allan Wigfield © Copyright by Shelby Patricia Cooley 2015
Exploration and Field Study of a Browser-based Password Manager using Icon-based Passwords ?

We carry out a hybrid lab and eld study of a password manager program, and report on usability and security. Our study explores iPMAN, a browser-based password manager that in addition uses a graphical password scheme for the master password. We present our ndings as a set of observations and insights expected to be of interest both to those exploring password managers, and graphical passwords. Motivated by our ndings, but also of independent interest, we also present a new salt generation method using blind signatures, to protect against oine attacks, decreasing user inconvenience by generating salt signicantly faster than earlier work (Halderman et al. 2005).
Design of Simultaneous Bi-Directional Transceivers Utilizing Capacitive Coupling for 3DICs in Face-to-Face Configuration

Capacitive-coupling-based simultaneously bi-directional transceivers for chip-to-chip communication in three-dimensional integrated circuits are presented. By employing a 4-level signaling strategy with a novel cascaded capacitor configuration, the proposed transceivers can transmit and receive data simultaneously through a single inter-chip coupling capacitor, and effectively improve the throughput per interconnect. In this work, the proposed cascaded capacitor structure and its signaling strategy are discussed in details and circuit solutions for transceivers are presented. A parasitic shielding technique is employed in the electrode design to improve signal swings without area overheads. A 16μm×20μm electrode provides the voltage margin as large as 195 mV at 1.2 V supply (verified by post-layout simulation) for signal sensing and recovery. The proposed transceivers are designed in a commercial 65-nm complementary metal-oxide-semiconductor technology.
Factor Analysis of Low-Frequency Repetitive Transcranial Magnetic Stimulation to the Temporoparietal Junction for Tinnitus

Objectives. We investigated factors that contribute to suppression of tinnitus after repetitive transcranial magnetic stimulation (rTMS). Methods. A total of 289 patients with tinnitus underwent active 1 Hz rTMS in the left temporoparietal region. A visual analog scale (VAS) was used to assess tinnitus loudness. All participants were interviewed regarding age, gender, tinnitus duration, laterality and pitch, audiometric parameters, sleep, and so forth. The resting motor thresholds (RMTs) were measured in all patients and 30 age- and gender-matched volunteers. Results. With respect to different factors that contribute to tinnitus suppression, we found improvement in the following domains: shorter duration, normal hearing (OR: 3.25, 95%CI: 2.01–5.27, p = 0.001), and without sleep disturbance (OR: 2.51, 95%CI: 1.56–4.1, p = 0.005) adjusted for age and gender. The patients with tinnitus lasting less than 1 year were more likely to show suppression of tinnitus (OR: 2.77, 95%CI: 1.48–5.19, p = 0.002) compared to those with tinnitus lasting more than 5 years. Tinnitus patients had significantly lower RMTs compared with healthy volunteers. Conclusion. Active low-frequency rTMS results in a significant reduction in the loudness of tinnitus. Significant tinnitus suppression was shown in subjects with shorter tinnitus duration, with normal hearing, and without sleep disturbance.
Feed form and energy concentration of the diet affect growth performance and digestive tract traits of brown-egg laying pullets from hatching to 17 weeks of age.

The influence of feed form and energy concentration of the diet on growth performance and the development of the gastrointestinal tract (GIT) was studied in brown-egg laying pullets. Diets formed a 2 x 5 factorial with 2 feed forms (mash vs. crumbles) and 5 levels of energy differing in 50 kcal AMEn/kg. For the entire study (0 to 17 wk of age) feeding crumbles increased ADFI (52.9 vs. 49.7 g; P < 0.001) and ADG (12.7 vs. 11.6 g; P < 0.001) and improved feed conversion ratio (FCR; 4.18 vs. 4.27; P < 0.001). An increase in the energy content of the diet decreased ADFI linearly (P < 0.001) and improved FCR quadratically (P < 0.01) but energy intake (kcal AMEn/d) was not affected. BW uniformity was higher (P < 0.05) in pullets fed crumbles than in those fed mash but was not affected (P > 0.05) by energy content of the diet. At 5, 10, and 17 wk of age, the relative weight (RW, % BW) of the GIT and the gizzard, and gizzard digesta content were lower (P < 0.05 to P < 0.001) and gizzard pH was higher (P < 0.05 to P < 0.001) in pullets fed crumbles than in pullets fed mash. Energy concentration of the diet did not affect any of the GIT variables studied. In summary, feeding crumbles improved pullet performance and reduced the RW of the GIT and gizzard, and increased gizzard pH at all ages. An increase in the energy content of the diet improved FCR from 0 to 17 wk of age. The use of crumbles and the increase in the AMEn content of the diet might be used adventageously when the objetive is to increase the BW of the pullets. However, crumbles affected the development and weight of the organs of the GIT, which might have negative effects on feed intake and egg production at the beginning of the egg laying cycle.
Methotrexate ameliorate T cell dependent autoimmune arthritis and encephalomyelitis but not antibody- or fibroblast-induced arthritis

DISCLAIMER The initial version of ARD Online First articles are papers in manuscript form that have been accepted and published in ARD Online but they have not been copy edited and not yet appeared in a printed issue of the journal. Copy editing may lead to differences between the Online First version and the final version including in the title; there may also be differences in the quality of the graphics. Edited, typeset versions of the articles may be published as they become available before final print publication.
Consumer Intentions to Revisit Online Retailers: A Mental Imagery Account

The current research explores the role of Web site characteristics, such as animation and iconic navigation aids, in predicting consumers’ self-reported intentions to revisit a retailer's Web site. An experimental study (n = 339) shows that Web site characteristics do not affect revisit intentions directly but through the vividness of mental images that consumers hold of the Web site as a whole. Vivid mental Web site imagery is stimulated by animation and facilitated by individual tendencies to put faith in intuitive rather than rational thinking, while it does not relate to the use of icons in navigation. The implications of these findings for researchers, Web designers and marketers are discussed.
Feature attention for binocular disparity in primate area MT depends on tuning strength.

Attending to a stimulus modulates the responses of sensory neurons that represent features of that stimulus, a phenomenon named "feature attention. " For example, attending to a stimulus containing upward motion enhances the responses of upward-preferring direction-selective neurons in the middle temporal area (MT) and suppresses the responses of downward-preferring neurons, even when the attended stimulus is outside of the spatial receptive fields of the recorded neurons (Treue S, Martinez-Trujillo JC. Nature 399: 575-579, 1999). This modulation renders the representation of sensory information across a neuronal population more selective for the features present in the attended stimulus (Martinez-Trujillo JC, Treue S. Curr Biol 14: 744-751, 2004). We hypothesized that if feature attention modulates neurons according to their tuning preferences, it should also be sensitive to their tuning strength, which is the magnitude of the difference in responses to preferred and null stimuli. We measured how the effects of feature attention on MT neurons in rhesus monkeys (Macaca mulatta) depended on the relationship between features-in our case, direction of motion and binocular disparity-of the attended stimulus and a neuron's tuning for those features. We found that, as for direction, attention to stimuli containing binocular disparity cues modulated the responses of MT neurons and that the magnitude of the modulation depended on both a neuron's tuning preferences and its tuning strength. Our results suggest that modulation by feature attention may depend not just on which features a neuron represents but also on how well the neuron represents those features.
Media Use, Public Affairs Knowledge and Voting in a Local Election

b One of the most striking trends in recent mass-media research has been the shift from an examination of attitudinal to cognitive effects of media messages. Numerous researchers have argued the merits of such a change in perspective. ' Many have presented data supportive of the position.2 While the trend is not without itscritics.3 it clearly has had impact on the field. Most researchers working in this new vein have acknowledged that the distinction between attitudes and cognitions is not always easily made on the operational level. The conceptual distinction. however, is clearer. Becker, McCombs and McLeod differentiated between attitudes, or "summary evaluations of objects by individuals," and cognitions, "stored information about those objects held by individuals. **4 Both attitudes and cognitions should guide behavior. The linkage between cognitions and behavior, however, has not been given much attention in recent research. Becker and McLeod did show that one type of cognition-issue salience-was linked to vote choice in the 1972 presidential elections.5 And Becker and Towers presented some evidence that knowledge was a significant variable in understanding the longterm effects of Watergate on Dolitical
Sparse channel estimation based on a p-norm-like constrained least mean fourth algorithm

In this paper, a p-norm-like constraint is utilized to develop a sparse least mean fourth algorithm for sparse channel estimation. By incorporating the p-norm-like constraint into the cost function of conventional least mean fourth (LMF) algorithm, a p-norm-like constraint least mean fourth (PNC-LMF) algorithm is achieved to exploit the sparsity property of the broadband sparse wireless communication channel. The proposed PNC-LMF algorithm aims to seek a tradeoff between the sparsity effects and the channel estimation errors, which is also verified by the simulation and compared with conventional LMF and previously reported popular sparse LMF algorithms. The simulated results show that the proposed PNC-LMF algorithm has faster convergence speed and lower channel estimation errors when the channel is sparse.