Miracle-dz/UniFAR-FTUs huggingface dataset:
Mentoring for Senior Preclinical Medical Students in a Faculty of Medicine

Background: Universities’ core values need to be translated into real learning design. At the end of the preclinical phase, the curriculum turned into a more comprehensive and full of trustworthiness of knowledge and attitudes. Meanwhile, the development of attitudes requires intensive support (mentoring). The team intended to translate the core values of Atma Jaya (Christianity, Excellence, Professional, Caring, KUPP) into an instructional design. Mentoring was the selected approach to build a dialogue and work together with students. In this article we presented the implementation of mentoring on the Elective Block of Medical Education (Block IPK) for the 7 th semester medical students at Atma Jaya School of Medicine (August-September 2015, 5 weeks). The Block IPK then was followed by an advanced mentoring until the end of November 2015. We intended to realise KUPP through mentorship throughout Block IPK until the end of the first semester of 2015/2016. In particular, this action research was intended to find answers to research questions: (1) What were perceived by the students throughout the mentoring in the Block IPK ? , (2) What were perceived by the students throughout the mentoring after Block IPK? , (3) What products were the students proud of after the mentoring? Method: Qualitative analysis using Delphi method were utilized to determine the main theme. Analyses were fulfilled using interpretive analysis. Data were taken from: reflective writing, FGD or interviews, email communication, and the mentors’ observation. The Delphi was performed in three rounds. Results: Findings showed positive impression on Block IPK. Students were aware of the meaning or significance of Block IPK. Field trip and working group were learning methods which considered to be important, because the methods had succeeded in generating meaningful learning for students. Approximately 40-50% of the students stated the significance of working group in Block IPK. Approximately 50-75% of students experienced personal cultivation. Approximately 67-75% of the class stated the superiority of Blok IPK and mentoring. Students appreciated the working group, which gave opportunities to have a discussion on campus with mentors. Mentoring had advantages in terms of students’ cultivation of the freedom of thought and to proceed further learning (advance learning). Conclusion: Students perceived positively to mentoring activities during and after the Block IPK. Mentoring benefited to personal cultivation, academic support, role modeling and leadership. The implication to medical education institutions was to implement a mentoring steadily.
The challenge of applying machine learning techniques to diagnose schizophrenia using multi-site fMRI data

One of the main challenges for the use of machine learning techniques in neuroimaging data is the small n, large p problem. Datasets usually contain only a few hundreds of instances (n), each of which is described using hundreds of thousands of features (p). In this dissertation, we explore the effects of reducing the number of features by analyzing 264 specific regions of interest of the brain, and increasing the number of instances by merging imaging data obtained from different scanning sites for distinguishing people with schizophrenia from healthy controls. Empirical results show that, using features related to functional connectivity of the brain, we can achieve an accuracy above the chance level (over 70%), when using data from a single scanning site for both training and testing. However, this performance decreases when additional data from a different scanning site is used as part of the training process. We attribute the decrease in performance to batch effects : technical noise introduced at different scanning sites that confound the biological signal of interest. Batch effects are often disregarded in association studies because there is often no statistically significant interaction between the scanning site and the variables being analyzed. In this work, we highlight important differences between association studies and prediction studies, and we argue that in the latter, batch effects matter. Our experiments reveal that not taking them into account reduces the performance of a learned classifier compared to using data from a single scanning site, even though this drastically reduces the size of the
A robust sample of submillimetre galaxies: constraints on the prevalence of dusty, high-redshift starbursts

The modest significance of most sources detected in current (sub)millimetre [(sub)mm] surveys can potentially compromise some analyses due to the inclusion of spurious sources in catalogues typically selected at ≥3.0-3. 5σ. Here, we develop and apply a dual-survey extraction technique to Submillimetre Common-User Bolometer Array (SCUBA) and Max-Planck Millimetre Bolometer (MAMBO) images of the Lockman Hole. Cut above 5σ, our catalogue of submillimetre galaxies (SMGs) is more robust than previous samples, with a reduced likelihood of real, but faint SMGs (beneath and around the confusion limit) entering via superposition with noise. Our selection technique yields 19 SMGs in an effective area of 165 arcmin 2 , of which we expect at most two to be due to chance superposition of SCUBA and MAMBO noise peaks. The effective flux limit of the survey (∼4 mJy at ∼ 1 mm) is well matched to our deep 1.4-GHz image (a = 4.6 μJy beam -1 ). The former is sensitive to luminous, dusty galaxies at extreme redshifts whilst the latter probes the z ≤ 3 regime. A high fraction of our robust SMGs (∼80 per cent) have radio counterparts which, given the ∼10 per cent contamination by spurious sources, suggests that very distant SMGs (z >> 3) are unlikely to make up more than ∼10 per cent of the bright SMG population. This implies that almost all of the S 1 mm ≥ 4 mJy SMG population is amenable to study via the deepest current radio imaging. We use these radio counterparts to provide an empirical calibration of the positional uncertainty in SMG catalogues. We then go on to outline the acquisition of redshifts for radio-identified SMGs, from sample selection in the submm. to counterpart selection in the radio and optical/infrared, to slit placement on spectrograph masks. We determine a median of z = 2.05 ± 0.41 from a sample of six secure redshifts for unambiguous radio-identified submm sources and z = 2.14 ± 0.27 when we include submm sources with multiple radio counterparts and/or less reliable redshifts. These figures are consistent with previous estimates, suggesting that our knowledge of the median redshift of bright SMG population has not been biased by the low significance of the source catalogues employed.
Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors

The IFT-A complex is divided into core and peripheral subcomplexes composed of IFT122/IFT140/IFT144 and IFT43/IFT121/IFT139, respectively. IFT139-KO and IFT144-KO cell analyses show that IFT139 is dispensable for IFT-A assembly but essential for retrograde GPCR trafficking, whereas IFT144 is essential for IFT-A assembly and GPCR ciliary entry.
New Public Management a re-packaging of extant techniques? Some archival evidence from an Irish semi-state power company

Purpose The purpose of this paper is to explore, if, similar to other management initiatives, new public management may be a repackaging of already existent concepts. Emerging in the 1970s and 1980s as an innovative way to manage public sector elements, new public management affected both the ownership and management of public sector companies, services and utilities. Minimal research has been undertaken previously, using historic archival sources of public entities, to explore if elements of the concept originated prior to the 1970s. Design/methodology/approach This research draws on archival records from a publicly owned electricity company, covering about three decades from 1946, during which a large investment project was undertaken by the company. This study draws on key tenets of what is today called new public management, examining prior research to ascertain if similar elements were present in the case organisation. Findings When reviewing the progress of the investment project, many of the key elements of new public management emerged, even during the early part of the project. Originality/value There is little historical research on the origins of new public management, and the findings here suggest that it may not be entirely new. While this does not at all invalidate existing research, it suggests that new public management may be to an extent a repackaging of previously extant techniques. This opens up possibilities for future historic research in terms of how and why it was repackaged, and also what was/was not repackaged.
FD 2TD analysis of electromagnetic field propagation in multipole debye media with and without convolution

This paper deals with the time-domain numerical calculation of electromagnetic (EM) fields in linearly dispersive media described by multipole Debye model. The frequency-dependent finite-difference time-domain (FD2TD) method is applied to solve Debye equations using convolution integrals or by direct integration. Original formulations of FD2TD methods are proposed using different approaches. In the first approach based on the solution of convolution equations, the exponential analytical behavior of the convolution integrand permits an efficient recursive FD2TD solution. In the second approach, derived by circuit theory, the transient equations are directly solved in time domain by the FD2TD method. A comparative analysis of several FD2TD methods in terms of stability, dispersion, computational time and memory is carried out.
Small Molecule Modulators of Endogenous and Co-chaperone-stimulated Hsp70 ATPase Activity*

The molecular chaperone and cytoprotective activities of the Hsp70 and Hsp40 chaperones represent therapeutic targets for human diseases such as cancer and those that arise from defects in protein folding; however, very few Hsp70 and no Hsp40 modulators have been described. Using an assay for ATP hydrolysis, we identified and screened small molecules with structural similarity to 15-deoxyspergualin and NSC 630668-R/1 for their effects on endogenous and Hsp40-stimulated Hsp70 ATPase activity. Several of these compounds modulated Hsp70 ATPase activity, consistent with the action of NSC 630668-R/1 observed previously (Fewell, S. W., Day, B. W., and Brodsky, J. L. (2001) J. Biol. Chem. 276, 910–914). In contrast, three compounds inhibited the ability of Hsp40 to stimulate Hsp70 ATPase activity but did not affect the endogenous activity of Hsp70. Two of these agents also compromised the Hsp70/Hsp40-mediated post-translational translocation of a secreted pre-protein in vitro. Together, these data indicate the potential for continued screening of small molecule Hsp70 effectors and that specific modulators of Hsp70-Hsp40 interaction can be obtained, potentially for future therapeutic use.
Resource-constrained project scheduling: An evaluation of adaptive control schemes for parameterized sampling heuristics

For most computationally intractable problems there exists no simple heuristic that consistently outperforms all other heuristics. One remedy is to bundle simple heuristics into composite ones in a fixed and predetermined way. Adaptive control schemes take this approach one step further by dynamically combining algorithms. Several such algorithms have been proposed recently in various settings, yet an experimental investigation comparing them with other contemporary methods has been lacking. The aim here is to close this gap by a comprehensive computational study on the field of resource-constrained project scheduling. Also shown is how to improve effectiveness of the best algorithm by means of randomized sampling. Finally, revealed are several advantages of adaptive control schemes over other algorithms which facilitate the OR practitioner's task of designing good algorithms for newly arising problems.
Approach- and Withdrawal-Oriented Responses to Social Rejection: The Role of Asymmetrical Frontal Cortical Activity

Approachand Withdrawal-Oriented Responses to Social Rejection: The Role of Asymmetrical Frontal Cortical Activity. (December 2009) Carly Kathryn Peterson, B.A., University of Wisconsin – Madison Chair of Advisory Committee: Dr. Eddie Harmon-Jones Ostracism arouses negative affect. However, little is known about variables that influence the intensity of these negative affective responses. Two studies seek to fill this void by incorporating work on approachand withdrawal-related emotional states and their associated cortical activations. Study 1 found that following ostracism, anger related directly to relative left frontal cortical activation. Study 2 used unilateral hand contractions to manipulate frontal cortical activity prior to an ostracizing event. Righthand contractions, compared to left-hand contractions, caused greater relative left frontal cortical activation during the hand contractions as well as during ostracism. Also, righthand contractions caused more self-reported anger in response to being ostracized. Within-condition correlations revealed patterns of associations between ostracisminduced frontal asymmetry and emotive responses to ostracism consistent with Study 1. Taken together, these results suggest that asymmetrical frontal cortical activity affects angry responses to ostracism, with greater relative left frontal cortical activity being associated with increased anger.
HIV Infection, Risk Factors, and Preventive Services Utilization among Female Sex Workers in the Mekong Delta Region of Vietnam

Background Risk behaviors among female sex workers (FSW) are considerable drivers of HIV infections in Vietnam, especially transmission between high-risk and low-risk groups. We assessed HIV prevalence and its correlates among FSWs, and the use of preventive services among this community in the Mekong Delta region, southern Vietnam. Methods A cross-sectional survey of 1,999 FSWs was carried out in five provinces including Ben Tre, Hau Giang, Kien Giang, Tien Giang, and Vinh Long between June, 2006 and June, 2007. We interviewed participants face-to-face in order to elicit information about their lives and potential risk factors, and we tested their sera to determine their HIV status. We then performed multivariate logistic regression analyses to investigate factors associated with HIV infection. Results Seventeen percent of the participating FSWs were street-based sex workers (SSWs) and the rest (83%) were entertainment establishment-based sex workers (ESWs). Unprotected sex with regular and casual clients in the past month was frequent among study participants (40.5% and 33.5% respectively). However, few respondents (1.3%) had ever injected drugs. Only 2.1% (95% confidence interval (CI): 1.6%–2.8%) of FSWs were found to be infected with HIV. HIV prevalence among SSWs was greater than among ESWs (3.8% vs. 1.8%, p = 0.02, respectively). Increased risk for HIV infection was significantly associated with the number of clients per month (adjusted odd ratio (aOR) = 2.65, 95% CI: 1.26–5.59). Conclusions Interventions to reduce unsafe sex and drug injection, and to increase uptake of HIV testing among FSWs are necessary. Differences in HIV prevalence and its correlates by type of sex work emphasize the importance of constrained contexts in shaping risk behaviors among FSWs; that should be considered in designing HIV prevention programs.
Multiple Spatial and Kinetic Subpopulations of CaMKII in Spines and Dendrites as Resolved by Single-Molecule Tracking PALM

Calcium/calmodulin-dependent protein kinase II (CaMKII) is essential for synaptic plasticity underlying memory formation. Some functions of CaMKII are mediated by interactions with synaptic proteins, and activity-triggered translocation of CaMKII to synapses has been heavily studied. However, CaMKII actions away from the postsynaptic density (PSD) remain poorly understood, in part because of the difficulty in discerning where CaMKII binds in live cells. We used photoactivated localization microscopy (PALM) in rat hippocampal neurons to track single molecules of CaMKIIα, mapping its spatial and kinetic heterogeneity at high resolution. We found that CaMKIIα exhibits at least three kinetic subpopulations, even within individual spines. Latrunculin application or coexpression of CaMKIIβ carrying its actin-binding domain strongly modulated CaMKII diffusion, indicating that a major subpopulation is regulated by the actin cytoskeleton. CaMKII in spines was typically more slowly mobile than in dendrites, consistent with presence of a higher density of binding partners or obstacles. Importantly, NMDA receptor stimulation that triggered CaMKII activation prompted the immobilization and presumed binding of CaMKII in spines not only at PSDs but also at other points up to several hundred nanometers away, suggesting that activated kinase does not target only the PSD. Consistent with this, single endogenous activated CaMKII molecules detected via STORM immunocytochemistry were concentrated in spines both at the PSD and at points quite distant from the synapse. Together, these results indicate that CaMKII mobility within spines is determined by association with multiple interacting proteins, even outside the PSD, suggesting diverse mechanisms by which CaMKII may regulate synaptic transmission.
Mining the NCI Anticancer Drug Discovery Databases: Genetic Function Approximation for the QSAR Study of Anticancer Ellipticine Analogues

The U.S. National Cancer Institute (NCI) conducts a drug discovery program in which approximately 10,000 compounds are screened every year in vitro against a panel of 60 human cancer cell lines from different organs of origin. Since 1990, approximately 63,000 compounds have been tested, and their patterns of activity profiled. Recently, we analyzed the antitumor activity patterns of 112 ellipticine analogues using a hierarchical clustering algorithm. Dramatic coherence between molecular structures and activity patterns was observed qualitatively from the cluster tree. In the present study, we further investigate the quantitative structure-activity relationships (QSAR) of these compounds, in particular with respect to the influence of p53-status and the CNS cell selectivity of the activity patterns. Independent variables (i.e., chemical structural descriptors of the ellipticine analogues) were calculated from the Cerius2 molecular modeling package. Important structural descriptors, including partial atomic charges on the ellipticine ring-forming atoms, were identified by the recently developed genetic function approximation (GFA) method. For our data set, the GFA method gave better correlation and cross-validation results (R2 and CVR2 were usually approximately 0.3 higher) than did classical stepwise linear regression. A procedure for improving the performance of GFA is proposed, and the relative advantages and disadvantages of using GFA for QSAR studies are discussed.
Frogs, Ponds, and Culture

Would you rather be the big frog in a small pond or the small frog in a big pond? In three studies, we demonstrate that the entry preference depends on culture. Study 1 found a higher big pond preference for East Asian, versus European American, students. Studies 2A and 2B replicated this big pond preference in behavioral intent across educational and organizational settings for Chinese, as compared to United States, working adults. Study 3 demonstrated cultural variation in frog–pond decisions was not explained by comparison processes that characterize postentry self-regard but rather by concerns for prestige. Together, findings highlight how a cultural lens informs psychological processes that shape entry decision-making.
Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity

At the interface between T cell and antigen-presenting cell (APC), peptide antigen presented by MHC (pMHC) binds to the T cell receptor (TCR) and initiates signaling. The mechanism of TCR signal initiation, or triggering, remains unclear. An interesting aspect of this puzzle is that although soluble agonist pMHCs cannot trigger TCR even at high concentrations, the same ligands trigger TCR very efficiently on the surface of APCs. Here, using lipid bilayers or plastic-based artificial APCs with defined components, we identify the critical APC-associated factors that confer agonist pMHCs with such potency. We found that CD4+ T cells are triggered by very low numbers of monomeric agonist pMHCs anchored on fluid lipid bilayers or fixed plastic surfaces, in the absence of any other APC surface molecules. Importantly, on bilayers, plastic surfaces, or real APCs, endogenous pMHCs did not enhance TCR triggering. TCR triggering, however, critically depended upon the adhesiveness of the surface and an intact T cell actin cytoskeleton. Based on these observations, we propose the receptor deformation model of TCR triggering to explain the remarkable sensitivity and specificity of TCR triggering.
Consumers' perception of control over online information disclosure. an electronic focus group study

This study focuses on consumers’ perception of control over personal information disclosure on the Internet. Specifically, we examine how consumers perceive controlling their personal data that online companies collect for marketing and customer relationship management purposes. We aim to answer this research problem by clarifying 1) how do consumers express the perception of control over their personal information, and 2) how do consumers perceive controlling their personal information disclosure. Our empirical data is based on four computer-mediated focus group interviews. Our findings show that the perception of control is combined with all stages of personal data utilization: collection, storage and usage. Thus, consumers keep these stages in mind when thinking about their attitudes towards the collection and offering of their personal information. The interviewees also spontaneously mentioned various means with which they control personal data. Perceived trust towards companies, own initiative and permission-based marketing were also combined to the control speech. In summary, the interviewees mostly perceived that they were not controlling their personal data on the Internet. Only when they were talking about control methods of the information disclosure stage, they expressed the perception of control.
Australian museums in the ‘age of risk’: a case study

ABSTRACT Balancing the needs and demands of audiences, sponsors and shareholders and making wise curatorial decisions concerning the politics of display in an increasingly risk averse society, are dilemmas many contemporary museums are experiencing. This article utilizes a case study comparing curatorial approaches to ‘risk management’ at two Australian museums (Art Gallery of New South Wales Sydney, and Museum of Old and New Art Tasmania), in regard to contentious and ‘difficult’ topics. Based on empirical data, analysis will consider the role museums play as agents of social change in respect to counteracting prejudices and promoting appreciation of cultural differences through exhbitionary displays. Against the backdrop of the ‘culture wars’ and impact of media reporting, the writings of Ulrich Beck inform discussions surrounding different perspectives of museum professionals and audiences and how displays in the art museum conform to or contradict Beck’s vision of ‘reflective’ modernity in an increasingly ‘world risk society. ’