Miracle-dz/UniFAR-FTUs huggingface dataset:
FPGA Implementation of Steinhart–Hart Equation for Accurate Thermistor Linearization

This paper presents fixed point operation-based Field Programmable Gate Arrays (FPGA) implementation of Steinhart–Hart Equation (SHHE) for thermistor linearization. FPGA implementation issues of SHHE are presented and their solutions are proposed and experimentally validated in a LabVIEWTM environment. Experimental temperature calibration, performed using a M/S Fluke drywell calibrator, revealed a lowest nonlinearity of 0.11% for an industrial grade thermistor in the input temperature range from −20 °C to 120 °C. Therefore, the main contribution of this work is to demonstrate the lowest nonlinearity for a wider temperature range. This work is expected to be very useful to instrumentation engineers as it employs a time-tested technique, for thermistor linearization in FPGA, leading to the lowest nonlinearity for a larger input temperature range.
Mapping Early, Middle and Late Rice Extent Using Sentinel-1A and Landsat-8 Data in the Poyang Lake Plain, China

Areas and spatial distribution information of paddy rice are important for managing food security, water use, and climate change. However, there are many difficulties in mapping paddy rice, especially mapping multi-season paddy rice in rainy regions, including differences in phenology, the influence of weather, and farmland fragmentation. To resolve these problems, a novel multi-season paddy rice mapping approach based on Sentinel-1A and Landsat-8 data is proposed. First, Sentinel-1A data were enhanced based on the fact that the backscattering coefficient of paddy rice varies according to its growth stage. Second, cropland information was enhanced based on the fact that the NDVI of cropland in winter is lower than that in the growing season. Then, paddy rice and cropland areas were extracted using a K-Means unsupervised classifier with enhanced images. Third, to further improve the paddy rice classification accuracy, cropland information was utilized to optimize distribution of paddy rice by the fact that paddy rice must be planted in cropland. Classification accuracy was validated based on ground-data from 25 field survey quadrats measuring 600 m × 600 m. The results show that: multi-season paddy rice planting areas effectively was extracted by the method and adjusted early rice area of 1630.84 km2, adjusted middle rice area of 556.21 km2, and adjusted late rice area of 3138.37 km2. The overall accuracy was 98.10%, with a kappa coefficient of 0.94.
Indigenous Pseudomonas spp. Strains from the Olive (Olea europaea L.) Rhizosphere as Effective Biocontrol Agents against Verticillium dahliae: From the Host Roots to the Bacterial Genomes

The use of biological control agents (BCA), alone or in combination with other management measures, has gained attention over the past decades, driven by the need to seek for sustainable and eco-friendly alternatives to confront plant pathogens. The rhizosphere of olive (Olea europaea L.) plants is a source of bacteria with potential as biocontrol tools against Verticillium wilt of olive (VWO) caused by Verticillium dahliae Kleb. A collection of bacterial isolates from healthy nursery-produced olive (cultivar Picual, susceptible to VWO) plants was generated based on morphological, biochemical and metabolic characteristics, chemical sensitivities, and on their in vitro antagonistic activity against several olive pathogens. Three strains (PIC25, PIC105, and PICF141) showing high in vitro inhibition ability of pathogens' growth, particularly against V. dahliae, were eventually selected. Their effectiveness against VWO caused by the defoliating pathotype of V. dahliae was also demonstrated, strain PICF141 being the rhizobacteria showing the best performance as BCA. Genotypic and phenotypic traits traditionally associated with plant growth promotion and/or biocontrol abilities were evaluated as well (e.g., phytase, xylanase, catalase, cellulase, chitinase, glucanase activities, and siderophore and HCN production). Multi-locus sequence analyses of conserved genes enabled the identification of these strains as Pseudomonas spp. Strain PICF141 was affiliated to the “Pseudomonas mandelii subgroup,” within the “Pseudomonas fluorescens group,” Pseudomonas lini being the closest species. Strains PIC25 and PIC105 were affiliated to the “Pseudomonas aeruginosa group,” Pseudomonas indica being the closest relative. Moreover, we identified P. indica (PIC105) for the first time as a BCA. Genome sequencing and in silico analyses allowed the identification of traits commonly associated with plant-bacteria interactions. Finally, the root colonization ability of these olive rhizobacteria was assessed, providing valuable information for the future development of formulations based on these strains. A set of actions, from rhizosphere isolation to genome analysis, is proposed and discussed for selecting indigenous rhizobacteria as effective BCAs.
Two distinct cytoplasmic regions of the β2 integrin chain regulate RhoA function during phagocytosis

αMβ2 integrins mediate phagocytosis of opsonized particles in a process controlled by RhoA, Rho kinase, myosin II, Arp2/3, and actin polymerization. αMβ2, Rho, Arp2/3, and F-actin accumulate underneath bound particles; however, the mechanism regulating Rho function during αMβ2-mediated phagocytosis is poorly understood. We report that the binding of C3bi-opsonized sheep red blood cells (RBCs) to αMβ2 increases Rho-GTP, but not Rac-GTP, levels. Deletion of the cytoplasmic domain of β2, but not of αM, abolished Rho recruitment and activation, as well as phagocytic uptake. Interestingly, a 16–amino acid (aa) region in the membrane-proximal half of the β2 cytoplasmic domain was necessary for activating Rho. Three COOH-terminal residues (aa 758–760) were essential for β2-induced accumulation of Rho at complement receptor 3 (CR3) phagosomes. Activation of Rho was necessary, but not sufficient, for its stable recruitment underneath bound particles or for uptake. However, recruitment of active Rho was sufficient for phagocytosis. Our data shed light on the mechanism of outside-in signaling, from ligated integrins to the activation of Rho GTPase signaling.
HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

Objective HCV is a major cause of chronic liver disease worldwide, but the role of neutralising antibodies (nAbs) in its natural history remains poorly defined. We analysed the in vivo role of hypervariable region 1 (HVR1) for HCV virion properties, including nAb susceptibility. Design Analysis of HCV from human liver chimeric mice infected with cell-culture-derived prototype genotype 2a recombinant J6/JFH1 or HVR1-deleted variant J6/JFH1ΔHVR1 identified adaptive mutations, which were analysed by reverse genetics in Huh7.5 and CD81-deficient S29 cells. The increased in vivo genomic stability of the adapted viruses facilitated ex vivo density analysis by ultracentrifugation and in vivo neutralisation experiments addressing the role of HVR1. Results In vivo, J6/JFH1 and J6/JFH1ΔHVR1 depended on single substitutions within amino acids 867–876 in non-structural protein, NS2. The identified A876P-substitution resulted in a 4.7-fold increase in genomic stability. In vitro, NS2 substitutions enhanced infectivity 5–10-fold by increasing virus assembly. Mouse-derived mJ6/JFH1A876P and mJ6/JFH1ΔHVR1/A876P viruses displayed similar heterogeneous densities of 1.02–1.1 g/mL. Human liver chimeric mice loaded with heterologous patient H (genotype 1a) immunoglobulin had partial protection against mJ6/JFH1A876P and complete protection against mJ6/JFH1ΔHVR1/A876P. Interestingly, we identified a putative escape mutation, D476G, in mJ6/JFH1A876P. This mutation in hypervariable region 2 conferred 6.6-fold resistance against H06 IgG in vitro. Conclusions The A876P-substitution bridges in vitro and in vivo studies using J6/JFH1-based recombinants. We provide the first in vivo evidence that HVR1 protects cross-genotype conserved HCV neutralisation epitopes, which advocates the possibility of using HVR1-deleted viruses as vaccine antigens to boost broadly reactive protective nAb responses.
Performance Comparisons Between Thumb-Based and Finger-Based Input on a Small Touch-Screen Under Realistic Variability

The potential benefits of thumb-based touch interaction have not been fully exploited due to its usability problems and performance deterioration. Despite the well-known problems, mobile phone users often prefer thumb-based input method in their daily context of use. Without understanding input performance under realistic variability, design solutions may not address the problems adequately. This research aims to evaluate performance of one-handed thumb-based input compared to cradled finger-based input for the large number of users and varying task conditions. By investigating performance under a range of user- and task-variability, common patterns can be identified to help infer realistic performance in context of use. For this experiment, 259 participants were recruited balanced on gender and age. They performed user testing of moving an icon on a mobile touch-screen. Overall, the one-handed thumb input showed a 30% reduction in throughput compared to the cradled finger-based input, with significant reduction in speed and accuracy. Reduced throughput is attributed to inaccuracy rather than speed. In addition, the partial effects of touch position, dragging direction, and target size were investigated and quantified. In conclusion, performance could maintain constant throughput only for the finger-based input of limited task conditions, when realistic variability was introduced. Also, high variance of throughput for the thumb-based input led to poor conformity to Fitts’s law. The findings have implications for design of thumb-based touch interface to offset performance reduction and characterizing performance measure for thumb-based input method.
The radical SAM protein HemW is a heme chaperone

Radical S-adenosylmethionine (SAM) enzymes exist in organisms from all kingdoms of life, and all of these proteins generate an adenosyl radical via the homolytic cleavage of the S–C(5′) bond of SAM. Of particular interest are radical SAM enzymes, such as heme chaperones, that insert heme into respiratory enzymes. For example, heme chaperones insert heme into target proteins but have been studied only for the formation of cytochrome c-type hemoproteins. Here, we report that a radical SAM protein, the heme chaperone HemW from bacteria, is required for the insertion of heme b into respiratory chain enzymes. As other radical SAM proteins, HemW contains three cysteines and one SAM coordinating an [4Fe–4S] cluster, and we observed one heme per subunit of HemW. We found that an intact iron–sulfur cluster was required for HemW dimerization and HemW-catalyzed heme transfer but not for stable heme binding. A bacterial two-hybrid system screen identified bacterioferritins and the heme-containing subunit NarI of the respiratory nitrate reductase NarGHI as proteins that interact with HemW. We also noted that the bacterioferritins potentially serve as heme donors for HemW. Of note, heme that was covalently bound to HemW was actively transferred to a heme-depleted, catalytically inactive nitrate reductase, restoring its nitrate-reducing enzyme activity. Finally, the human HemW orthologue radical SAM domain–containing 1 (RSAD1) stably bound heme. In conclusion, our findings indicate that the radical SAM protein family HemW/RSAD1 is a heme chaperone catalyzing the insertion of heme into hemoproteins.
An Empirical Study of the Complex Relationships between Requirements Engineering Processes and Other Processes that Lead to Payoffs in Productivity, Quality, and Risk Management

Requirements engineering is an important component of effective software engineering, yet more research is needed to demonstrate the benefits to development organizations. While the existing literature suggests that effective requirements engineering can lead to improved productivity, quality, and risk management, there is little evidence to support this. We present empirical evidence showing how requirements engineering practice relates to these claims. This evidence was collected over the course of a 30-month case study of a large software development project undergoing requirements process improvement. Our findings add to the scarce evidence on RE payoffs and, more importantly, represent an in-depth explanation of the role of requirements engineering processes in contributing to these benefits. In particular, the results of our case study show that an effective requirements process at the beginning of the project had positive outcomes throughout the project lifecycle, improving the efficacy of other project processes, ultimately leading to improvements in project negotiation, project planning, and managing feature creep, testing, defects, rework, and product quality. Finally, we consider the role collaboration had in producing the effects we observed and the implications of this work to both research and practice
Determining of camera rotation from vanishing points of lines on horizontal planes

A novel method that uses vanishing points of horizontal lines, but not parallel to each other, for estimating the change of camera azimuth is proposed. Although indoor scenes contain many such lines, there also exist non-horizontal lines which should be discarded from the group of lines for estimating the azimuth change. Distinguishing non-horizontal lines from horizontal ones is difficult for a static image, but possible for the dynamic imagery because non-horizontal lines show different motion patterns as the camera moves. <<ETX>>
Integrating spatial and temporal contexts into a factorization model for POI recommendation

ABSTRACT Matrix factorization is one of the most popular methods in recommendation systems. However, it faces two challenges related to the check-in data in point of interest (POI) recommendation: data scarcity and implicit feedback. To solve these problems, we propose a Feature-Space Separated Factorization Model (FSS-FM) in this paper. The model represents the POI feature spaces as separate slices, each of which represents a type of feature. Thus, spatial and temporal information and other contexts can be easily added to compensate for scarce data. Moreover, two commonly used objective functions for the factorization model, the weighted least squares and pairwise ranking functions, are combined to construct a hybrid optimization function. Extensive experiments are conducted on two real-life data sets: Gowalla and Foursquare, and the results are compared with those of baseline methods to evaluate the model. The results suggest that the FSS-FM performs better than state-of-the-art methods in terms of precision and recall on both data sets. The model with separate feature spaces can improve the performance of recommendation. The inclusion of spatial and temporal contexts further leverages the performance, and the spatial context is more influential than the temporal context. In addition, the capacity of hybrid optimization in improving POI recommendation is demonstrated.
Bivariate Archimedean copula models for censored data in non-life insurance

We describe a methodology based on archimedean copulas for analyzing nonlife insurance data with censoring present. Specifically, we propose a graphical selection procedure for the nonparametric estimation of the generator. An actual loss-ALAE date set is used for the numerical illustrations and for comparisons of our approach to a few others.
Swarm aggregations of heterogeneous multi-agent systems

This paper investigates the problem of swarm aggregations of heterogeneous multi-agent systems. Comparing with the existing studies on swarm aggregations of homogeneous multi-agent systems, this paper is much more resembling the practical situations, where the agents have different dynamics. We show that the heterogeneous agents will gather with a certain error under some assumptions and conditions. The stability properties have been proven by theoretical analysis and verified via numerical simulation. The stability of the heterogeneous multi-agent systems has been achieved based on matrix theory and the Lyapunov stability theorem. Numerical simulation is given to demonstrate the effectiveness of the theoretical result.
Reduced Time to Breast Cancer Diagnosis with Coordination of Radiological and Clinical Care

Introduction Diagnostic delays for breast problems is a current concern in British Columbia and diagnostic pathways for breast cancer are currently under review. Breast centres have been introduced in Europe and reported to facilitate diagnosis and treatment. Guidelines for breast centers are outlined by the European Society for Mastology (EUSOMA). A Rapid Access Breast Clinic (RABC) was developed at our hospital applying the concept of triple evaluation for all patients and navigation between clinicians and radiologists. We hypothesize that the Rapid Access Breast Clinic will decrease wait times to diagnosis and minimize duplication of services compared to usual care. Methods A retrospective review was undertaken looking at diagnostic wait times and the number of diagnostic centres involved for consecutive patients seen by breast surgeons with diagnostic workups performed either in the traditional system (TS) or the RABC. Only patients presenting with a new breast problem were included in the study. Results Patients seen at the RABC had a decreased time to surgical consultation (33 vs 86 days, p<0.0001) for both malignant (36 vs 59 days, p=0.0007) and benign diagnoses (31 vs 95 days, p<0.0001). Furthermore, 13% of the patients referred to the surgeon in the TS without a diagnosis were eventually diagnosed with a malignancy and waited a mean of 84 days for initial surgical assessment. Of the patients seen at the RABC, 5% required investigation at more than one institution compared to 39% patients seen in the TS (p<0.0001). Cancer patients had a shorter time from presentation to surgery in the RABC (64 vs 92 days, p=0.009). Conclusion The establishment of the RABC has significantly reduced the time to surgical consultation, time to breast cancer surgery, and duplication of investigations for patients with benign and malignant breast complaints. It is feasible to introduce a EUSOMA-based breast clinic in the Canadian Health Care System and improvements in diagnostic wait times are seen. We recommend the expansion of coordinated care to other sites.
Equalizer 2.0–Convergence of a Parallel Rendering Framework

Developing complex, real world graphics applications which leverage multiple GPUs and computers for interactive 3D rendering tasks is a complex task. It requires expertise in distributed systems and parallel rendering in addition to the application domain itself. We present a mature parallel rendering framework which provides a large set of features, algorithms and system integration for a wide range of real-world research and industry applications. Using the <inline-formula><tex-math notation="LaTeX">$\mathsf{Equalizer}$</tex-math><alternatives><mml:math><mml:mi mathvariant="sans-serif">Equalizer</mml:mi></mml:math><inline-graphic xlink:href="eilemann-ieq1-2870822.gif"/></alternatives></inline-formula> parallel rendering framework, we show how a wide set of generic algorithms can be integrated in the framework to help application scalability and development in many different domains, highlighting how concrete applications benefit from the diverse aspects and use cases of <inline-formula><tex-math notation="LaTeX">$\mathsf{Equalizer}$</tex-math><alternatives><mml:math><mml:mi mathvariant="sans-serif">Equalizer</mml:mi></mml:math><inline-graphic xlink:href="eilemann-ieq2-2870822.gif"/></alternatives></inline-formula>. We present novel parallel rendering algorithms, powerful abstractions for large visualization setups and virtual reality, as well as new experimental results for parallel rendering and data distribution.
A single-institution experience with metallic ureteral stents: a cost-effective method of managing deficiencies in ureteral drainage.

INTRODUCTION The limitations of traditional ureteral stents in patients with deficiencies in ureteral drainage have resulted in frequent stent exchanges. The implementation of metallic stents was introduced to improve the patency rates of patients with chronic upper urinary tract obstruction, obviating the need for frequent stent exchanges. We report our clinical experiences with the use of metallic ureteral stents in the management of poor ureteral drainage. MATERIALS AND METHODS Fifty patients underwent metallic ureteral stent placement from 2009 to 2012. Stent failure was defined as an unplanned stent exchange, need for nephrostomy tube placement, increasing hydronephrosis with stent in place, or an elevation in serum creatinine. Stent life was analyzed using the Kaplan-Meier methodology, as this was a time dependent continuous variable. A cost analysis was similarly conducted. RESULTS A total of 97 metallic stents were placed among our cohort of patients: 63 in cases of malignant obstruction, 33 in the setting of cutaneous ureterostomies, and 1 in an ileal conduit urinary diversion. Overall, stent failure occurred in 8.2% of the stents placed. Median stent life was 288.4 days (95% CI: 277.4-321.2 days). The estimated annual cost for traditional polymer stents (exchanged every 90 days) was $9,648-$13,128, while the estimated cost for metallic stents was $4,211-$5,313. CONCLUSION Our results indicate that metallic ureteral stent placement is a technically feasible procedure with minimal complications and is well tolerated among patients. Metallic stents can be left in situ for longer durations and provide a significant financial benefit when compared to traditional polymer stents.