Miracle-dz/UniFAR-FTUs huggingface dataset:
Rural Development: From Practices and Policies towards Theory

Both in practice and policy a new model of rural development is emerging. This paper reflects the discussions in the impact research programme and suggests that at the level of associated theory also a fundamental shift is taking place. The modernization paradigm that once dominated policy, practice and theory is being replaced by a new rural development paradigm. Rural development is analyzed as a multi-level, multi-actor and multi-facetted process rooted in historical traditions that represents at all levels a fundamental rupture with the modernization project. The range of new quality products, services and forms of cost reduction that together comprise rural development are understood as a response by farm families to both the eroding economic base of their enterprises and to the new needs and expectations European society has of the rural areas. Rural development therefore is largely an autonomous, self-driven process and in its further unfolding agriculture will continue to play a key role, although it is a role that may well change. This article provides an introduction to the nine papers of this ‘special issue’ and the many reconfiguration processes embodied in rural development that they address.in rural development
NOTES AND CORRESPONDENCE Coupled Kelvin-Wave and Mirage-Wave Instabilities in Semigeostrophic Dynamics

A weak instability mode, associated with phase-locked counterpropagating coastal Kelvin waves in horizontal anticyclonic shear, is found in the semigeostrophic (SG) equations for stratified flow in a channel. This SG instability mode approximates a similar mode found in the Euler equations in the limit in which particle-trajectory slopes are much smaller than f /N, where f is the Coriolis frequency and N . f the buoyancy frequency. Though weak under normal parameter conditions, this instability mode is of theoretical interest because its existence accounts for the failure of an Arnol’d-type stability theorem for the SG equations. In the opposite limit, in which the particle motion is purely vertical, the Euler equations allow only buoyancy oscillations with no horizontal coupling. The SG equations, on the other hand, allow a physically spurious coastal ‘‘mirage wave,’’ so called because its velocity field vanishes despite a nonvanishing disturbance pressure field. Counterpropagating pairs of these waves can phase-lock to form a spurious ‘‘mirage-wave instability. ’’ Closer examination shows that the mirage wave arises from failure of the SG approximations to be self-consistent for trajectory slopes * f /N.
Work characteristics predict psychiatric disorder: prospective results from the Whitehall II Study.

OBJECTIVES: The impact of work on the risk of future psychiatric disorder has been examined in few longitudinal studies. This was examined prospectively in a large epidemiological study of civil servants. METHODS: In the Whitehall II study, a longitudinal, prospective cohort study of 6895 male and 3413 female London based civil servants, work characteristics measured at baseline (phase 1: 1985-8) and first follow up (phase 2: 1989) were used to predict psychiatric disorder measured by a 30 item general health questionnaire (GHQ) at phase 2 and phase 3 follow up (phase 3: 1991-3). Work characteristics and GHQ were measured at all three phases. RESULTS: Low social support at work and low decision authority, high job demands and effort-reward imbalance were associated with increased risk of psychiatric disorder as assessed by the GHQ at follow up adjusting for age, employment grade, and baseline GHQ score. CONCLUSIONS: Social support and control at work protect mental health while high job demands and effort-reward imbalance are risk factors for future psychiatric disorder. Intervention at the level of work design, organisation, and management might have positive effects on mental health in working populations.
Host nutrition alters the variance in parasite transmission potential

The environmental conditions experienced by hosts are known to affect their mean parasite transmission potential. How different conditions may affect the variance of transmission potential has received less attention, but is an important question for disease management, especially if specific ecological contexts are more likely to foster a few extremely infectious hosts. Using the obligate-killing bacterium Pasteuria ramosa and its crustacean host Daphnia magna, we analysed how host nutrition affected the variance of individual parasite loads, and, therefore, transmission potential. Under low food, individual parasite loads showed similar mean and variance, following a Poisson distribution. By contrast, among well-nourished hosts, parasite loads were right-skewed and overdispersed, following a negative binomial distribution. Abundant food may, therefore, yield individuals causing potentially more transmission than the population average. Measuring both the mean and variance of individual parasite loads in controlled experimental infections may offer a useful way of revealing risk factors for potential highly infectious hosts.
Learning with Options that Terminate Off-Policy

A temporally abstract action, or an option, is specified by a policy and a termination condition: the policy guides the option behavior, and the termination condition roughly determines its length. Generally, learning with longer options (like learning with multi-step returns) is known to be more efficient. However, if the option set for the task is not ideal, and cannot express the primitive optimal policy well, shorter options offer more flexibility and can yield a better solution. Thus, the termination condition puts learning efficiency at odds with solution quality. We propose to resolve this dilemma by decoupling the behavior and target terminations, just like it is done with policies in off-policy learning. To this end, we give a new algorithm, Q(beta), that learns the solution with respect to any termination condition, regardless of how the options actually terminate. We derive Q(beta) by casting learning with options into a common framework with well-studied multi-step off policy learning. We validate our algorithm empirically, and show that it holds up to its motivating claims.
Efficacy of pramipexole, a novel dopamine agonist, as monotherapy in mild to moderate Parkinson's disease

A total of 335 patients with early Parkinson's disease (PD) were enrolled in a multicenter, randomized, double-blind trial designed to assess the efficacy and safety of pramipexole. Entry was restricted to patients with idiopathic PD who were not receiving levodopa. Pramipexole was administered according to an ascending dose schedule up to 4.5 mg/d. During the 7-week dose-escalation phase, each subject was titrated to his or her maximally tolerated dose of study medication. This was followed by a 24-week period of maintenance therapy. The mean daily dose during the maintenance period was 3.8 mg. Pramipexole significantly reduced the severity of PD symptoms and signs compared with placebo, as measured by decreases in parts II (Activities of Daily Living) and III (Motor Examination) of the Unified Parkinson's Disease Rating Scale at week 24 compared with baseline (p ≤ 0.0001). Differences between the active drug and placebo groups emerged at week 3 (1.5 mg/d) in the ascending-dose interval and persisted throughout the maintenance phase (p ≤ 0.0001). The majority of patients completed the study (pramipexole 83%, placebo 80%). In the assessment of adverse events, nausea, insomnia, constipation, somnolence, and visual hallucinations occurred more frequently in the pramipexole treatment group compared with placebo patients. No clinically significant changes were noted in blood pressure or pulse rate. Overall, these results indicate that pramipexole is safe and effective in the treatment of early PD.
SCN8A mutation in a child presenting with seizures and developmental delays

The SCN8A gene encodes the sodium voltage-gated channel alpha subunit 8. Mutations in this gene have been associated with early infantile epileptic encephalopathy type 13. With the use of whole-exome sequencing, a de novo missense mutation in SCN8A was identified in a 4-yr-old female who initially exhibited symptoms of epilepsy at the age of 5 mo that progressed to a severe condition with very little movement, including being unable to sit or walk on her own.
An ERP Study of Expectation Violation in a Social Comparison Context

Previous studies pay more attention to the cognitive control in classical cognitive conflict task but the time-course of the expectation violation in a social comparison context remains unknown. Event-related potentials (ERPs) were recorded to explore the electrophysiological correlates of expectation violation by using a reward feedback paradigm in a social comparison context. Results showed that: Expectation incongruent stimuli (EIS) elicited a more positive ERP deflection (P400-700) than did expectation congruent stimuli (ECS) between 400 and 700 ms. Furthermore, dipole source analysis revealed that the generator of P400-700 was localized near the posterior cingulate gyrus (PCC), which might be involved in the monitoring and controlling of reward expectation conflict (expectation violation). EIS also elicited a more negative ERP deflection (N1000-1500) than did ECS between 1,000 and 1,500 ms. The generator of N1000-1500 was localized near the parahippocampal gyrus, which might be related to unpleasant .
Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of γ-Secretase-Mediated Intramembrane Proteolysis

Presenilin (PS1 or PS2) is the catalytic component of the γ-secretase complex, which mediates the final proteolytic processing step leading to the Alzheimer's disease (AD)-characterizing amyloid β-peptide. PS is cleaved during complex assembly into its characteristic N- and C-terminal fragments. Both fragments are integral components of physiologically active γ-secretase and harbor the two critical aspartyl residues of the active site domain. While the minimal subunit composition of γ-secretase has been defined and numerous substrates were identified, the cellular mechanism of the endoproteolytic cleavage of PS is still unclear. We addressed this pivotal question by investigating whether familial AD (FAD)-associated PS1 mutations affect the precision of PS endoproteolysis in a manner similar to the way that such mutations shift the intramembrane cleavage of γ-secretase substrates. We demonstrate that all FAD mutations investigated still allow endoproteolysis to occur. However, the precision of PS1 endoproteolysis is affected by PS1 mutations. Comparing the cleavage products generated by a variety of PS1 mutants revealed that specifically cleavages at positions 293 and 296 of PS1 are selectively affected. Systematic mutagenesis around the cleavage sites revealed a stepwise three amino acid spaced cleavage mechanism of PS endoproteolysis reminiscent to the ε-, ζ-, and γ-cleavages described for typical γ-secretase substrates, such as the β-amyloid precursor protein. Our findings therefore suggest that intramembranous cleavage by γ-secretase and related intramembrane-cleaving proteases may generally occur via stepwise endoproteolysis.
Power‐Base Research in Marketing Channels: A Narrative Review

This paper provides a contemporary and comprehensive review of work in the marketing channel field that is based on French and Raven's power‐base theory. It traces the development of theoretic, conceptual and methodological orthodoxies from the 1970s. Mirroring the movement towards the relationship marketing paradigm, the paper considers the theory's empirical contribution to knowledge of power, conflict, trust and commitment in marketing channels. Limitations relating to inconsistency of treatment, contradictory findings and the simplification of complex phenomena are identified. Nevertheless, current work extends power‐base theory to other cultures, other styles of research and to the area of supply chains. The review raises questions about the value of contribution made using this theory and notes the surprising absence within the channels literature of the broader, current debate about power. To illustrate, the paper shows how Clegg's (1989. Frameworks of Power. London: Sage) circuits of power framework, if applied to channel contexts, could address forms of power that are invisible, anonymous and not necessarily negative. Applications and methods are discussed, opening a space wherein a broadened understanding of power is integrated within a focus upon cooperative channels.
Adenosine deaminase in childhood pulmonary tuberculosis: diagnostic value in serum.

The diagnostic value of serum adenosine deaminase (ADA) activity was evaluated in childhood pulmonary tuberculosis. Serum ADA levels were measured in 20 children diagnosed with pulmonary tuberculosis (group 1) and 150 children (group 2) including 128 with tuberculosis infection (Mantoux test positive) and 22 healthy children. In group 1, the mean serum ADA activity was 74.06 +/- 18.5 U/l, which was significantly (p < 0.001) higher than that of group 2 (40.36 +/- 12.0 U/l). A serum ADA level of > or = 53.76 U/l had a sensitivity of 100 per cent, specificity of 90.7 per cent, positive predictive value of 58.8 per cent, and a negative predictive value of 100 per cent in children with tuberculosis disease. To conclude, measurement of serum ADA activity was a useful diagnostic tool in childhood pulmonary tuberculosis.
Preservation of organic matter in marine sediments: controls, mechanisms, and an imbalance in sediment organic carbon budgets?

The burial of organic matter (OM) in marine sediments represents the major link between “active” surface pools of carbon in the oceans, atmosphere, on land, and in marine sediment, and carbon pools that cycle on much longer, geologic time scales (i.e., carbon in sedimentary rock, coal, and petroleum deposits). It also plays some role in controlling atmospheric CO2 and O2 on these long time scales because in a highly simplified fashion OM burial in sediments can be thought of in terms of the balance between primary production and respiration on land and in the oceans.
Growth, body composition, and nutritional status in children and adolescents with Crohn's disease.

OBJECTIVE To examine growth, body composition, and nutritional status in a large sample of children, adolescents, and young adults with Crohn's disease (CD). METHODS One hundred thirty-two subjects (48 females) with CD, aged 5 to 25 years, and 66 healthy control subjects (37 females) of similar age. Growth, nutritional status, and body composition were measured by anthropometry and dual-energy x-ray absorptiometry. Genetic potential of linear growth was predicted using the adjusted heights of Himes et al. Pubertal status and skeletal age were assessed. Average Pediatric Crohn's Disease Activity Index (PCDAI) and lifetime steroid exposure (in milligrams per day) were obtained from medical charts. The variables were examined in relation to gender and measures of disease activity. RESULTS Males and females with CD did not differ by age, disease duration, or PCDAI. Males with CD had significantly lower values for growth and nutritional status than control subjects (z-scores for weight: -0.66 +/- 1.18 vs. 0.26 +/- 0.95, P = 0.00002; height -0.81 +/- 1.14 vs. 0.28 +/- 0.93, P = 0.00001; adjusted height -1.05 +/- 1.03 vs. 0.40 +/- 1.03, P = 0.00001) and delayed skeletal age of 0.9 +/- 1.6 years. Impaired linear growth in the males was present regardless of pubertal stage. Associations between disease severity indicators and growth parameters were more consistent for females. CONCLUSIONS Crohn's disease is associated with impaired growth. Despite similarities in disease duration, activity, and lifetime steroid exposure, growth in males was more impaired. Gender may confer risk for impaired growth in CD.
Monitoring intravenous recombinant tissue plasminogen activator thrombolysis for acute ischemic stroke with diffusion and perfusion MRI.

BACKGROUND AND PURPOSE Intravenous recombinant tissue plasminogen activator (rtPA) administration is an effective therapy for ischemic stroke when initiated within 3 hours and possibly up to 6 hours after symptom onset. To improve patient selection, a fast diagnostic tool that allows reliable diagnosis of hemorrhage and ischemia, vessel status, and tissue at risk at an early stage may be useful. We studied the feasibility of stroke MRI for the initial evaluation and follow-up monitoring of patients undergoing intravenous thrombolysis. METHODS Stroke MRI (diffusion- and perfusion-weighted imaging [DWI and PWI, respectively], magnetic resonance angiography, and T2-weighted imaging) was performed before, during, or after thrombolysis and on days 2 and 5. We assessed clinical scores (National Institutes of Health Stroke Scale [NIHSS], Scandinavian Stroke Scale [SSS], Barthel Index, and Rankin scale) at days 1, 2, 5, 30, and 90. Furthermore, we performed volumetric analysis of infarct volumes on days 1, 2, and 5 as shown in PWI, DWI, and T2-weighted imaging. RESULTS Twenty-four patients received rtPA within a mean time interval after symptom onset of 3.27 hours and stroke MRI of 3.43 hours. Vessel occlusion was present in 20 of 24 patients; 11 vessels recanalized (group 1), and 9 did not (group 2). The baseline PWI lesion volume was significantly larger (P=0.008) than outcome lesion size in group 1, whereas baseline DWI lesion volume was significantly smaller (P=0.008) than final infarct size in group 2. Intergroup outcome differed significantly for all scores at days 30 and 90 (all P<0.01). Intragroup differences were significant in group 1 for change in SSS and NIHSS between day 1 and day 30 (P=0.003) and for SSS only between day 1 and day 90 (P=0.004). CONCLUSIONS Stroke MRI provides comprehensive prognostically relevant information regarding the brain in hyperacute stroke. Stroke MRI may be used as a single imaging tool in acute stroke to identify and monitor candidates for thrombolysis. It is proposed that stroke MRI is safe, reliable, and cost effective; however, our data do not prove this assumption. Early recanalization achieved by thrombolysis can save tissue at risk if present and may result in significantly smaller infarcts and a significantly better outcome.
Pyoderma gangrenosum associated with hidradenitis suppurativa

Pyoderma gangrenosum (PG) is associated with a number of systemic diseases. PG in association with hidradenitis suppurativa (HS) has been rarely reported. We describe six patients (three men, three women; aged 35–51 years), who developed PG on a background of HS. The onset of PG occurred only after HS had been present for at least two decades. No relationship in disease activity between the two conditions was observed. Three patients described previous severe adolescent acne vulgaris, one had concurrent systemic lupus erythematosus and another had chronic iron‐deficiency anaemia. The course of PG was severe and refractory in four patients, who required treatment including high‐dose oral corticosteroids, ciclosporin, intravenous immunoglobulin and intravenous cyclophosphamide.
Effects of Standardized Testing on Teachers' Emotions, Pedagogy and Professional Interactions with Others

The purpose of this qualitative study is to determine the relationships among high-stakes testing, the practice of teaching and teachers' emotions. Through an inductive approach the emotions, pedagogy and interactions with students, colleagues and parents are examined to determine the possible impact testing has on teachers' professional lives and philosophies. Methodologically, there are two components to this study; interview and observation. Data is collected through individual interviews conducted twice with each of the six teacher participants followed by two classroom observations. A group interview at the end of this study should add to the validity and afford the teacher participants an opportunity to meet and share experiences. Member checks and fieldnotes add insight and validity. Findings of this study indicate that high-stakes testing both positively and negatively impacts curriculum, teachers' emotions and the professional interactions teachers have with others. Since testing is such a basic component of our current educational system, this study indicates the need for further investigation into the current mode of testing and possible alternatives, Findings also support the need for further study into teachers' emotions as they relate to their professional lives.
Information Asymmetry, Price Momentum, and the Disposition Effect

Economists have long been puzzled by the tendency of investors to sell winning investments too soon and hold losing investments too long. Several behavioral explanations for this phenomenon, known as the disposition effect, have been advanced. This paper demonstrates that disposition effects are not intrinsically at odds with rational behavior. Specifically, we show (i) that disposition effects arise quite naturally in a world with changing information asymmetry, (ii) that existing empirical tests rejecting an information-based explanation are inconclusive, and (iii) that disposition effects are consistent with price momentum. Further, we derive new empirical implications relating disposition behavior to trading volume, return variability, and price dynamics.
The effects of Pre -harvest practices on food loss in Gucha Sub - County, Kisii County , Kenya

One of the crucial and significant factors for ensuring a successful agricultural food production among smallholder farmers is pre-harvesting procedures. Pre-harvesting is considered the last step in agronomy that ushers in food harvesting, and should be approached as the first one in the post-production system, due to its impact on the amount of food loss and waste. In most rural areas of the world, little focus has been invested towards understanding how household food-resource handling procedures contribute to incidences of food insecurity. This paper investigates the effects of pre-harvest practices on food loss in Gucha Sub-County, Kisii County, Kenya. The paper is based on a study that focused on household food-resource handling procedures and food security in Gucha Sub-County. Qualitative and quantitative research techniques were used to collect data on pre-harvesting variable and the effect of this variable on food loss and eventual food insecurity in the study area. The study found that pre-harvest conditions and actions in the field can directly or indirectly lead to food losses at later stages in the chain, as differences in production and agronomic practices can result in different quality at harvest, different suitability for transport and, different storage stability and different shelf-life after harvest. In this regard, pre-harvest phase helps us in understanding the level of preparedness of the smallholder farmer in the next step, which is harvesting. It is the observation of the study that, if preharvesting is done well before the actual harvest, and smallholder farmers have knowledge on how to avoid pre-harvest losses, less food is going to be lost at harvest thus countering food insecurity.