Miracle-dz/UniFAR-FTUs huggingface dataset:
Working with the enemy? Social work education and men who use intimate partner violence

Abstract This article examines service user involvement in social work education. It discusses the challenges and ethical considerations of involving populations who may previously have been excluded from user involvement initiatives, raising questions about the benefits and challenges of their involvement. The article then provides discussion of an approach to service user involvement in social work education with one of these populations, men who use violence in their intimate relationships, and concludes by considering the implications of their involvement for the social work academy.
Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate

Granulocytes with the hybrid characteristics of eosinophils and basophils have been identified in the bone marrow and peripheral blood of humans with myeloid leukemias. We now describe a technique by which such hybrid granulocytes can be developed in vitro from normal cord blood precursors cultured in the presence of recombinant human interleukin (rhIL) 3 (350 pM) and rhIL-5 (200 pM) in a plastic vessel coated with Matrigel. After 14 d in culture, 90 +/- 3% (mean +/- standard error of the mean) of the nonadherent cells cultured in the Matrigel-coated flasks contained both eosinophil and basophil granules, as indicated by staining with Wright's and Giemsa stains. Of the nonadherent cells, 93 +/- 1% contained cyanide-resistant peroxidase, and 88 +/- 2% were toluidine blue-positive, characteristic of eosinophil and basophil granules, respectively. Transmission electron micrographs showed hybrid cells containing ultrastructurally distinct eosinophil granules with developing crystalline cores and basophil granules with reticular structures. These 14-d cord blood-derived cell cultures showed strong hybridization signals for eosinophil-derived neurotoxin by RNA blot analysis and contained 78 ng histamine per 10(6) cells. When the granulocytes were removed from cytokine-containing medium and suspended without Matrigel in RPMI 1640 medium containing 10% fetal calf serum (FCS), more than 80% of the granulocytes excluded trypan blue for as long as 5 d, and 93% had developed into eosinophils at 6 d. Conditioned medium prepared over 48 h from the 14-d cell cultures (hybrid granulocytes) sustained the 4-d viability in vitro of 78% of peripheral blood eosinophils from atopic donors. In comparison, 13% survived in RPMI 1640 containing 10% FCS alone. This viability- sustaining activity was nearly completely neutralized by an anti- granulocyte/macrophage colony-stimulating factor (GM-CSF) antibody and was only minimally reduced by anti-IL-3 or IL-5. Thus, cells possessing both eosinophil and basophil granules by both histochemical and ultrastructural analysis can be developed from normal progenitors in vitro in response to eosinophilopoietic cytokines and Matrigel. Their subsequent spontaneous development into mature eosinophils suggests that hybrid granulocytes are part of a normal developmental sequence during eosinophilopoiesis. Furthermore, these hybrid granulocytes are capable of autoregulation through elaboration of GM-CSF, which sustains their viability.
Enhanced endothelin-1-mediated leg vascular tone in healthy older subjects.

UNLABELLED Advanced age is associated with a decreased leg blood flow and reduced physical activity. Endothelin (ET-1), a powerful vasoconstrictor, may play a role in the increased leg vascular tone in older men. objectives: to assess the ET-1-mediated vascular tone in the legs of healthy sedentary older men, both before and after 8 wk of exercise training. methods: in 8 younger subjects (19-50 yr) and 8 older men (67-76 yr), bilateral leg blood flow was measured using venous occlusion plethysmography before and after antagonizing ET-1 (using selective ET(A/B)-receptor antagonists). In older men, reversibility of the observations was assessed after 8 wk of cycling. results: ET-receptor inhibition increased leg blood flow significantly more in older men compared with younger individuals (29 +/- 9% and 10 +/- 4%, respectively, P < 0.05). Eight-week cycling training increased baseline blood flow in older men. The blood flow response to ET-receptor inhibition in older men was not affected by the training program (25 +/- 8%, P > 0.05 for comparison with pretraining). The flow ratio (blood flows infused leg/noninfused leg) decreased significantly by training from 26 +/- 8% to 7+3% (P < 0.05). CONCLUSION the increased baseline vascular tone in aging is at least in part mediated by the endothelin. Eight-weeks cycling training in older sedentary men decreased leg vascular tone and seems to partly decrease the ET-1-mediated vascular tone.
Is Getting Tough With Low-Risk Kids a Good Idea? The Effect of Failure to Appear Detention Stays on Juvenile Recidivism

Although the juvenile justice system has adopted many alternatives to detention, the practice of detaining youth for failing to appear in court remains common. Despite its widespread use, it is unclear whether this form of detainment is harmful to juvenile offenders—especially to those who pose no credible threat to public safety. Accordingly, using data from the Florida Department of Juvenile Justice (FDJJ) and propensity score matching, we assess whether failure to appear (FTA) detention increases recidivism for low-risk youth. The results indicate that FTA detention increases official recidivism, technical recidivism, and re-detainment, and suggest that alternate policies be considered for low-risk juvenile offenders.
Formal Comparison of Dual-Parameter Temporal Discounting Models in Controls and Pathological Gamblers

Temporal or delay discounting refers to the phenomenon that the value of a reward is discounted as a function of time to delivery. A range of models have been proposed that approximate the shape of the discount curve describing the relationship between subjective value and time. Recent evidence suggests that more than one free parameter may be required to accurately model human temporal discounting data. Nonetheless, many temporal discounting studies in psychiatry, psychology and neuroeconomics still apply single-parameter models, despite their oftentimes poor fit to single-subject data. Previous comparisons of temporal discounting models have either not taken model complexity into account, or have overlooked particular models. Here we apply model comparison techniques in a large sample of temporal discounting datasets using several discounting models employed in the past. Among the models examined, an exponential-power model from behavioural economics (CS model, Ebert & Prelec 2007) provided the best fit to human laboratory discounting data. Inter-parameter correlations for the winning model were moderate, whereas they were substantial for other dual-parameter models examined. Analyses of previous group and context effects on temporal discounting with the winning model provided additional theoretical insights. The CS model may be a useful tool in future psychiatry, psychology and neuroscience work on inter-temporal choice.
Receptor Interacting Protein 2 (RIP2) Is Dispensable for OVA-Induced Airway Inflammation in Mice

Purpose Asthma is a pulmonary chronic inflammatory disease characterized by airway obstruction and hyperresponsiveness. Pattern recognition receptors are known to play a key role in the development of allergic diseases as well as host defenses against microbial infection. Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with the severity of allergic asthma in children. In this study, we examined the role of RIP2 in the development of allergic airway inflammation in a mouse model. Methods Airway inflammation was induced in mice through intranasal administration of ovalbumin (OVA) after 2 intraperitoneal immunizations with OVA. Lung inflammation and mucus hypersecretion were examined histologically and total cell infiltration in bronchoalveolar (BAL) fluids was determined. Levels of the Th2-related cytokines, IL-5 and IL-13, in lung extracts were measured by ELISA. Serum antigen-specific IgE and IgG1 levels were also assessed. Results OVA-induced lung inflammation and mucus hypersecretion were not different between WT and RIP2-deficient mice. The IL-5 and IL-13 levels in the bronchoalveolar (BAL) fluids were also not impaired in RIP2-deficient mice compared to WT mice. Moreover, RIP2 deficiency did not affect serum OVA-specific IgG1 and IgE levels. Conclusions Our results suggest that RIP2 is not associated with the development of allergic airway inflammation.
A Programming Framework Supporting An Ethology-based Behavior Control Architecture

A robot programming language (PLEASE) is to be proposed together with an ethology-based action-selection (EASE) architecture, where following features are supported; Hierarchical tree-structured behavior organization, layer-tailored arbiter programming, abstract expression of real world situation by logically connecting outputs of perception filters, concurrent behaviors
Consumer control in service recovery: beyond decisional control

Purpose Focusing on decisional control of the outcome provides only a partial picture of how firms may handle customer complaints and ignores many (alternative) opportunities to recover the relationship with the customer when service delivery fails. The purpose of this paper is to introduce other types of control and explore their effects. Design/methodology/approach This paper conducts a field study using survey instruments to collect data from real consumers, which are subsequently analyzed with structural equations modeling. Findings The main conclusion of this study is that there is more to control than having a choice. Different types of control have differential main effects: behavioral control affects distributive justice, cognitive control affects procedural justice and decisional control affects interactional justice (which in turn affect satisfaction and loyalty). Research limitations/implications Service recovery research should include behavioral, cognitive and decisional control of the service recovery as aspects of the firm’s organizational response to customer complaints. The effects of these customer control types on satisfaction and loyalty are mediated by dimensions of justice. Practical implications Firms should offer complaining customers information to interpret and appraise the failure (cognitive control), opportunities to personally take action and influence the recovery (behavioral control), and choices in the recovery process and outcome (decisional control). Originality/value This study is the first to offer a comprehensive investigation of the subtle interrelationships between types of control and dimensions of justice in a service recovery context.
CONTACT-MEDIATED REVERSIBLE SUPPRESSION OF MYOGENESIS

Chondrocytes from the vertebral columns of 11-day chick embryos were cultured in the continuous presence of 5-bromodeoxyuridine (BUdR) Under these conditions the cells form multilayers but synthesize little extracellular matrix as determined by toluidine blue metachromasia or sulfate-35S incorporation into polysaccharide. Myogenic cells from the breast muscles of 11-day chick embryos formed myotubes when plated into BUdR-treated chondrocyte cultures. When plated on untreated chondrocyte multilayers or on multilayers which had been permitted to recover from BUdR treatment for 3 days, myogenic cells failed to form myotubes Since extracellular matrix is present in untreated chondrocyte cultures and reappears in multilayers recovering from BUdR treatment, it is suggested that extracellular matrix is the active agent in the suppression of myogenesis An attempt was made to duplicate the suppressing activity of multilayer cultures by using ion exchange resins as substrates for myogenic cells Myotubes formed on acidic and basic resin particles If extracellular matrix is the active suppressing agent, it may have to fulfill certain spatial distributional requirements before its activity is expressed
Self-dealing in securities issuance evidence from U.S. state bonds

Self-dealing in securities issuance can be characterized by an issuing manager who gains at the expense of the other existing stakeholders in the issue. The current system of public securities issuance for U.S. states potentially allows for conflict of interest through campaign contributions that benefit issuing officials. This paper shows that selecting a contributing underwriter through negotiation results in underpricing compared to a non-contributing underwriter. It also shows that an increase in the amount of campaign contributions by an underwriter results in an increase in the likelihood of selection. This result is mainly driven by lower-ranked underwriters. The pricing result is robust to endogeneity of the selection of a contributing underwriter. First-stage results of instrumental variable regression methods indicate that a large margin of victory for the political official is associated with a larger proportion of potentially conflicted deals. In addition, out of all the issues done through negotiation by underwriters who contributed, the issues that went to market in the year immediately after an election are the most underpriced.  I would like to thank the members of my dissertation committee: Nejat Seyhun, Jim Hines, Serdar Dinc, Sreedhar Bharath, and Sugato Bhattacharyya for guidance and support. In addition, I am grateful to Tyler Shumway, Vikram Nanda, Amy Dittmar, and seminar participants at the University of Michigan for helpful suggestions.
An energy-efficient and QoS-based MAC layer protocol for WMSN

Delivering multimedia content with precise quality of service over the energy-constrained sensor networks is enabling a new field popularly known as Wireless Multimedia Sensor Networks (WMSNs). The major goal of these Wireless Multimedia Sensor Networks is to deliver multimedia contents over wireless sensor networks with certain level of QoS guarantee while maintaining the efficient use of energy for such networks. We in this paper propose an energy efficient MAC layer protocol to deliver multimedia contents with certain degree of quality of service guarantee over such networks.
Texture Classification Approach Based on Combination of Edge & Co-occurrence and Local Binary Pattern

Texture classification is one of the problems which has been paid much attention on by computer scientists since late 90s. If texture classification is done correctly and accurately, it can be used in many cases such as Pattern recognition, object tracking, and shape recognition. So far, there have been so many methods offered to solve this problem. Near all these methods have tried to extract and define features to separate different labels of textures really well. This article has offered an approach which has an overall process on the images of textures based on Local binary pattern and Gray Level Co-occurrence matrix and then by edge detection, and finally, extracting the statistical features from the images would classify them. Although, this approach is a general one and is could be used in different applications, the method has been tested on the stone texture and the results have been compared with some of the previous approaches to prove the quality of proposed approach.
Impact of Pretreatment Noncontrast CT Alberta Stroke Program Early CT Score on Clinical Outcome After Intra-Arterial Stroke Therapy

Background and Purpose— The efficacy of intra-arterial treatment remains uncertain. Because most centers performing IAT use noncontrast CT (NCCT) imaging, it is critical to understand the impact of NCCT findings on treatment outcomes. This study aimed to compare functional independence and safety among patients undergoing intra-arterial treatment stratified by the extent of ischemic change on pretreatment NCCT. Methods— The study cohort was derived from multicenter trials of the Penumbra System. Inclusion criteria were anterior circulation proximal occlusion, evaluable pretreatment NCCT, and known time to reperfusion. Ischemic change was quantified using the Alberta Stroke Program Early CT Score (ASPECTS) and stratified into 3 prespecified groups for comparison: 0 to 4 (most ischemic change) versus 5 to 7 versus 8 to 10 (least ischemic change). Results— A total of 249 patients were analyzed: 40 with ASPECTS 0 to 4, 83 with ASPECTS 5 to 7, and 126 with ASPECTS 8 to 10. For ASPECTS 0 to 4, 5 to 7, and 8 to 10, respectively, good outcome (modified Rankin Scale score, 0–2) rates were 5%, 38.6%, and 46% (P<0.0001), and mortality rates were 55%, 28.9%, and 19% (P=0.0001). The only significant pairwise differences were between ASPECTS 0 to 4 and other groups. Symptomatic hemorrhage was more common with lower ASPECTS (P=0.02). Shorter time to reperfusion was significantly associated with better outcomes among patients with ASPECTS 8 to 10 (P=0.01). A similar relationship was seen for ASPECTS 5 to 7 but was not statistically significant. No such relationship was seen for ASPECTS 0 to 4. Conclusions— NCCT seems useful for excluding patients with the greatest burden of ischemic damage from futile intra-arterial treatment, which is unlikely to result in patient functional independence and increases the risk of hemorrhage.
Pharmacodynamics of Telomerase Inhibition and Telomere Shortening by Noncytotoxic Suramin

We reported that suramin is an effective chemosensitizer at noncytotoxic concentrations (<50 μM); this effect was observed in multiple types of human xenograft tumors in vitro and in vivo. Clinical evaluation of noncytotoxic suramin is ongoing. Because (a) suramin inhibits reverse transcriptase, (b) telomerase is a reverse transcriptase, and (c) inhibition of telomerase enhances tumor chemosensitivity, we studied the pharmacodynamics of noncytotoxic suramin on telomerase activity and telomere length in cultured cells and tumors grown in animals. In three human cancer cells that depend on telomerase for telomere maintenance (pharynx FaDu, prostate PC3, breast MCF7), suramin inhibited telomerase activity in cell extracts and intact cells at concentrations that exhibited no cytotoxicity (IC50 of telomerase was between 1 and 3 μM vs. >60 μM for cytotoxicity), and continuous treatment at 10–25 μM for 6 weeks resulted in gradual telomere shortening (maximum of 30%) and cell senescence (measured by β-galactosidase activity and elevation of mRNA levels of two senescence markers p16 and p21). In contrast, noncytotoxic suramin did not shorten the telomere in telomerase-independent human osteosarcoma Saos-2 cells. In mice bearing FaDu tumors, treatment with noncytotoxic suramin for 6 weeks resulted in telomere erosion in >95% of the tumor cells with an average telomere shortening of >40%. These results indicate noncytotoxic suramin inhibits telomerase, shortens telomere and induces cell senescence, and suggest telomerase inhibition as a potential mechanism of its chemosensitization.
Sleep Leads to Changes in the Emotional Memory Trace: Evidence from fMRI

After information is encoded into memory, it undergoes an off-line period of consolidation that may occur optimally during sleep. The consolidation process not only solidifies memories but also changes them in useful and adaptive ways. Here, we provide evidence for a shift in the neural structures used to retrieve emotional memories after a night of sleep compared to a day of wakefulness. Although the hippocampus was activated during successful retrieval of negative objects regardless of whether participants slept during a delay, sleep led to a shift from engagement of a diffuse memory retrieval network—including widespread activity in the lateral prefrontal and parietal cortices—to a more refined network of regions—including the amygdala and ventromedial pFC. Effective connectivity analyses revealed stronger connections among limbic regions after sleep versus wake. Although circadian effects may have contributed to these findings, our data strongly suggest that a night of sleep is sufficient to evoke qualitative changes in the emotional memory retrieval network.
Sensorimotor adaptation of speech in Parkinson's disease

The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force‐field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age‐matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD. © 2013 International Parkinson and Movement Disorder Society
Facial electromyography (fEMG) activities in response to affective visual stimulation

Recently, affective computing findings demonstrated that emotion processing and recognition is important in improving the quality of human computer interaction (HCI). In the present study, new data for a robust discrimination of three emotional states (negative, neutral and positive) employing two-channel facial electromyography (EMG) over zygomaticus major and corrugator supercilii will be presented. The facial EMG activities evoked upon viewing a standard set of pictures selected from the International Affective Picture System (IAPS) and additional self selected pictures revealed that positive pictures led to increased facial EMG activities over zygomaticus major (F (2, 471) = 4.23, p < 0.05), whereas negative pictures elicited greater facial EMG activities over corrugator supercilii (F (2, 476) = 3.06, p < 0.05). In addition, the correlation between facial EMG activities over these two sites and participants' ratings of stimuli pictures in dimension of valence measured by Self-Assessment Manikin (SAM) was significant (r = −0.63, p < 0.001, corrugator supercilii, r = 0.51, p < 0.05, zygomaticus major, respectively). Our results suggest that emotion inducing pictures elicit the intended emotions and that corrugator and zygomaticus EMG can effectively and reliably differentiate negative and positive emotions, respectively.