Miracle-dz/UniFAR-FTUs huggingface dataset:
A Model for Interphase Chromosomes and Evaluation of Radiation-Induced Aberrations

Abstract Holley, W. R. , Mian, I. S. , Park, S. J., Rydberg, B. and Chatterjee, A. A Model for Interphase Chromosomes and Evaluation of Radiation-Induced Aberrations. Radiat. Res. 158, 568–580 (2002). We have developed a theoretical model for evaluating radiation-induced chromosomal exchanges by explicitly taking into account interphase (G0/G1) chromosome structure, nuclear organization of chromosomes, the production of double-strand breaks (DSBs), and the subsequent rejoinings in a faithful or unfaithful manner. Each of the 46 chromosomes for human lymphocytes (40 chromosomes for mouse lymphocytes) is modeled as a random polymer inside a spherical volume. The chromosome spheres are packed randomly inside a spherical nucleus with an allowed overlap controlled by a parameter Ω. The rejoining of DSBs is determined by a Monte Carlo procedure using a Gaussian proximity function with an interaction range parameter σ. Values of Ω and σ have been found which yield calculated results of interchromosomal aberration frequencies that agree with a wide range of experimental data. Our preferred solution is one with an interaction range of 0.5 μm coupled with a relatively small overlap parameter of 0.675 μm, which more or less confirms previous estimates. We have used our model with these parameter values and with resolution or detectability limits to calculate yields of translocations and dicentrics for human lymphocytes exposed to low-LET radiation that agree with experiments in the dose range 0.09 to 4 Gy. Five different experimental data sets have been compared with the theoretical results. Essentially all of the experimental data fall between theoretical curves corresponding to resolution limits of 1 Mbp and 20 Mbp, which may reflect the fact that different investigators use different limits for sensitivity or detectability. Translocation yields for mouse lymphocytes have also been calculated and are in good agreement with experimental data from 1 cGy to 10 cGy. There is also good agreement with recent data on complex aberrations. Our model is expected to be applicable to both low- and high-LET radiation, and we include a sample prediction of the yield of interchromosomal rejoining in the dose range 0.22 Gy to 2 Gy of 1000 MeV/nucleon iron particles. This dose range corresponds to average particle traversals per nucleus ranging from 1.0 to 9.12.
Mainstreaming, resonance, and impersonal impact : Testing moderators of the cultivation effect for estimates of crime risk

People may use information from a variety of sources in constructing their judgments of crime risk, including direct experience, word-of-mouth, and the mass media. One hundred fifty-eight general population respondents provided 3 estimates of risk of violent crime: societal crime risk, personal crime risk to themselves in their own neighborhood, and personal crime risk to themselves in New York City. Respondents' level of television viewing was related to their estimates of societal crime risk and to their estimates of personal crime risk in New York City (p <.05) but not to their estimates of personal crime risk in their own neighborhood (p <.05). This pattern of results was qualified by a significant interaction (p <.05): all 3 risk estimates were related to respondents' level of television viewing only for those with high direct experience with crime, results that are consistent with Gerbner's concept of resonance (Gerbner et al., 1980). The implications for the concept of impersonal impact (Tyler, 1980) and Gerbner et al. concepts of cultivation and mainstreaming are also discussed.
Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration

Pharmaceutically active compounds (PhACs) and drugs of abuse (DAs) are two important groups of emerging environmental contaminants that have raised an increasing interest in the scientific community. A number of studies revealed their presence in the environment. This is mainly due to the fact that some compounds are not efficiently removed during wastewater treatment processes, being able to reach surface and groundwater and subsequently, drinking waters. This paper reviews the data regarding the levels of pharmaceuticals and illicit drugs detected in wastewaters and gives an overview of their removal by conventional treatment technologies (applying activated sludge) as well as advanced treatments such as membrane bioreactor. The paper also gives an overview of bank filtration practices at managed aquifer recharge sites and discusses the potential of this approach to mitigate the contamination by PhACs and DAs.
Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study.

BACKGROUND There are limited treatment options for tissue restoration and the prevention of degenerative changes in the knee. Stem cells have been a focus of intense preclinical research into tissue regeneration but limited clinical investigation. In a randomized, double-blind, controlled study, the safety of the intra-articular injection of human mesenchymal stem cells into the knee, the ability of mesenchymal stem cells to promote meniscus regeneration following partial meniscectomy, and the effects of mesenchymal stem cells on osteoarthritic changes in the knee were investigated. METHODS A total of fifty-five patients at seven institutions underwent a partial medial meniscectomy. A single superolateral knee injection was given within seven to ten days after the meniscectomy. Patients were randomized to one of three treatment groups: Group A, in which patients received an injection of 50 × 10⁶ allogeneic mesenchymal stem cells; Group B, 150 × 10⁶ allogeneic mesenchymal stem cells; and the control group, a sodium hyaluronate (hyaluronic acid/hyaluronan) vehicle control. Patients were followed to evaluate safety, meniscus regeneration, the overall condition of the knee joint, and clinical outcomes at intervals through two years. Evaluations included sequential magnetic resonance imaging (MRI). RESULTS No ectopic tissue formation or clinically important safety issues were identified. There was significantly increased meniscal volume (defined a priori as a 15% threshold) determined by quantitative MRI in 24% of patients in Group A and 6% in Group B at twelve months post meniscectomy (p = 0.022). No patients in the control group met the 15% threshold for increased meniscal volume. Patients with osteoarthritic changes who received mesenchymal stem cells experienced a significant reduction in pain compared with those who received the control, on the basis of visual analog scale assessments. CONCLUSIONS There was evidence of meniscus regeneration and improvement in knee pain following treatment with allogeneic human mesenchymal stem cells. These results support the study of human mesenchymal stem cells for the apparent knee-tissue regeneration and protective effects.
Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition

Context Impaired social cognition is a cardinal feature of Autism Spectrum Disorders (ASD) and Schizophrenia (SZ). However, the functional neuroanatomy of social cognition in either disorder remains unclear due to variability in primary literature. Additionally, it is not known whether deficits in ASD and SZ arise from similar or disease-specific disruption of the social cognition network. Objective To identify regions most robustly implicated in social cognition processing in SZ and ASD. Data Sources Systematic review of English language articles using MEDLINE (1995–2010) and reference lists. Study Selection Studies were required to use fMRI to compare ASD or SZ subjects to a matched healthy control group, provide coordinates in standard stereotactic space, and employ standardized facial emotion recognition (FER) or theory of mind (TOM) paradigms. Data Extraction Activation foci from studies meeting inclusion criteria (n = 33) were subjected to a quantitative voxel-based meta-analysis using activation likelihood estimation, and encompassed 146 subjects with ASD, 336 SZ patients and 492 healthy controls. Results Both SZ and ASD showed medial prefrontal hypoactivation, which was more pronounced in ASD, while ventrolateral prefrontal dysfunction was associated mostly with SZ. Amygdala hypoactivation was observed in SZ patients during FER and in ASD during more complex ToM tasks. Both disorders were associated with hypoactivation within the Superior Temporal Sulcus (STS) during ToM tasks, but activation in these regions was increased in ASD during affect processing. Disease-specific differences were noted in somatosensory engagement, which was increased in SZ and decreased in ASD. Reduced thalamic activation was uniquely seen in SZ. Conclusions Reduced frontolimbic and STS engagement emerged as a shared feature of social cognition deficits in SZ and ASD. However, there were disease- and stimulus-specific differences. These findings may aid future studies on SZ and ASD and facilitate the formulation of new hypotheses regarding their pathophysiology.
La formation des équipes d'entrepreneurs

Sur quels principes se fondent les associations entre les membres d’une equipe d’entrepreneurs ? Partant de cette question, le present article commence par expliquer ce qu’est l’entrepreneuriat collectif, avant de se focaliser sur la litterature scientifique concernant les groupes de fondateurs. Puis, il presente les resultats d’une etude menee sur 30 equipes d’entrepreneurs, a l’origine d’entreprises innovantes.Le constat est que deux categories de raisons guident la selection d’un co-fondateur : une est de type strategique et l’autre de type sociale. Chacune d’elles procure aux equipes des avantages et des inconvenients specifiques. Cependant, l’homogamie apparait comme le mecanisme le plus utilise et le plus approprie pour expliquer la formation des equipes d’entrepreneurs.
Automatic video scene segmentation based on spatial-temporal clues and rhythm

With ever increasing computing power and data storage capacity, the potential for large digital video libraries is growing rapidly.However, the massive use of video for the moment is limited by its opaque characteristics. Indeed, a user who has to handle and retrieve sequentially needs too much time in order to find out segments of interest within a video. Therefore, providing an environment both convenient and efficient for video storing and retrieval, especially for content-based searching as this exists in traditional textbased database systems, has been the focus of recent and important efforts of a large research community In this paper, we propose a new automatic video scene segmentation method that explores two main video features; these are spatial-temporal relationship and rhythm of shots. The experimental evidence we obtained from a 80 minutevideo showed that our prototype provides very high accuracy for video segmentation.
Exploring the acceptability of online sexually transmissible infection testing for rural young people in Victoria.

OBJECTIVE To examine the availability of and previous engagement with health services among rural young people and compare barriers and facilitators to using face-to-face and online sexual health testing and treatment. DESIGN Participants were recruited for focus groups and were asked to discuss their access to local sexual health services (what services they used, when, why and how) and then shown a website and asked to provide feedback about online STI testing. SETTING Community sporting clubs in two small country towns in Victoria. PARTICIPANTS Seven focus groups with fifty participants, grouped by gender and age, were conducted. MAIN OBJECTIVE MEASURE Participants views of accessible and acceptable services for STI testing. RESULTS Three main themes emerged from the analysis: (i) readiness to seek sexual health services; (ii) barriers and facilitators to using the local general practitioner; and (iii) barriers and facilitators to online testing, including 'using the mail during online STI testing' and 'cost of the online service'. In general, the participants described some concerns about accessing sexual health services locally. This was less discussion about availability of services and more about privacy, trust, reliability and using generalist health care providers for sexual health needs. CONCLUSION Free online testing services address issues of access for rural young people. While barriers external to rural sexual health services may remain, free online STI testing services are acceptable to these rural young people.
New peptide based freeze-dried kit [99mTc-HYNIC]-UBI 29-41 as a human specific infection imaging agent

Introduction: Ubiquicidin 29-41 (UBI) is a fragment of the cationic antimicrobial peptide that is present in various species including humans. The purpose of this study was to investigate radiochemical and biological characteristics of [6-hydrazinopyridine3-carboxylic acid (HYNIC)]-UBI 29-41 designed for the labeling with 99m Tc using tricine as coligand. Methods: Synthesis was preformed on a solid phase using a standard Fmoc strategy and HYNIC precursor coupled at the N-terminus. Purified peptide conjugate was labeled with 99m Tc at 100°C for 10 min. Radiochemical analysis involved ITLC and highperformance liquid chromatography methods. Peptide conjugate stability and affinity to human serum was challenged for 24 hours and its in vitro binding to bacteria was assessed. Biodistribution and accumulation of radiopeptide in staphylococcus aureus infected mice were studied using scintigraphy and ex vivo counting. Results: Radiolabeling was performed at high specific activities, and radiochemical purity was >95%. The stability of radiolabeled peptide in human serum was excellent. In vitro studies showed 70% of radioactivity was bound to bacteria. After injection into mice with a bacterial infection, removing from the circulation occurred mainly by renal clearance and site of infection was rapidly detected within 30 min. Target to nontarget muscle ratio was 2.099 ± 0.05% at 30 min post injection. Conclusion: [ 99m
Bone marrow reconstitution after high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation: effect of graft size.

BACKGROUND Peripheral blood progenitor cell transplantation is rapidly replacing autologous bone marrow transplantation as hematological support after high-dose chemotherapy for lymphoma or solid tumors. Controversy exists concerning the number of progenitor cells required for rapid and sustained bone marrow recovery, and as to which of the widely available methods for estimating this number should be employed. METHODS Forty consecutive patients with solid tumors or lymphomas received high-dose chemotherapy followed by autologous peripheral stem cell reinfusion. All stem cell harvests had been performed after mobilization with standard-dose chemotherapy followed by 300 micrograms G-CSF daily. Hematopoietic reconstitution was studied in relation to pertinent patient characteristics, to the size of the graft (in terms of the total number of mononuclear cells (MNC), the number of granulocyte/macrophage colony-forming units (CFU-GM) and the number of CD34+ cells, and to the use of G-CSF after stem cell reinfusion. RESULTS Both the numbers of CFU-GM and CD34+ cells reinfused, but not those of the MNC, correlated with granulocyte and platelet recovery. Patients who received at least 5 x 10(6) CD34+ cells/kg body weight achieved platelet transfusion independence on day 12 after reinfusion (range: day 7-37), significantly earlier than patients who had received less (p = 0.001). Thirty patients who received G-CSF (300 micrograms s.c. daily) after reinfusion achieved granulocyte recovery (> or = 500 x 10(6)/l) on day 9 (range: day 8-12), while this took a median of 15 days (range: day 10-28) in 10 consecutive patients not receiving G-CSF (p = 0.0003). In one patient who had received 1.4 x 10(6) CD34+ cells/kg, secondary bone marrow failure developed 3 months after transplantation. Reinfusion of cryopreserved autologous bone marrow was followed by prompt recovery. CONCLUSION Peripheral stem cells, mobilized by moderate-dose chemotherapy and G-CSF, lead to rapid and durable engraftment after high-dose chemotherapy when at least 3-5 x 10(6) CD34+ cells/kg are reinfused. Lower numbers may also be satisfactory, but are associated with slower granulocyte and platelet recoveries. A moderate dose of G-CSF after reinfusion significantly hastens granulocyte recovery without interfering with platelet recovery.
A content analysis of the New Iranian English Book's authenticity(Prpspect 1 for first grade of Iranian Junior secondary school)

Authenticity is one of the most controversial concepts in teaching/learning material analysis. This paper aims at discussing about this dimension of analysis toward language text-books. In fact the Iranian new published English book(called prospect1) for first grade of junior secondary school in EFL classrooms is under concentration here. Besides this article will concentrate on different aspects of authenticity (social and linguistic categories) in analyzing different parts of this new English book. Based on the results of this research, it can be concluded that the proportion of different aspects of authenticity in this book is not distributed properly. In fact there is just unremarkable proportion to target culture and informal linguistic elements and remarkable proportion to intercultural category of authenticity.
Schlafprobleme bei Soldaten und die Rolle traumatischer Ereignisse bei Auslandseinsätzen

Zusammenfassung. Fragestellung: Schlafprobleme, ihre Auswirkungen und Implikationen sind besonders im Kontext militarischer Missionen ein bedeutsames, jedoch wenig untersuchtes Thema. Methoden: Eine reprasentative Stichprobe von 1478 deutschen Bundeswehrsoldaten wurde 12 Monate nach Ende ihres Auslandseinsatzes mittels des Pittsburgh Sleep Quality Index (PSQI) sowie zu psychischen Storungen (DSM-IV-TR) und traumatischen Ereignissen personlich untersucht und mit N = 880 Soldaten ohne Auslandseinsatz verglichen. Ergebnisse: 41 % der Soldaten mit und 38 % der Soldaten ohne Auslandseinsatz erfullten die PSQI-Kriterien fur Schlafprobleme. Traumatische Einsatzereignisse waren mit mehr Schlafproblemen assoziiert (β: 0.7, 95 % KI: 0.4 – 1.0, p < .001). In Abhangigkeit der Anzahl traumatischer Einsatzereignisse wurde ein hoherer PSQI-Gesamtwert bei inzidenten psychischen Storungen (β: 1.2, 95 % KI: 0.3 – 2.1, p = .011), aber auch bei Soldaten ohne psychische Storungen (β: 0.7, 95 % KI: 0.3 – 1.1, p = .001) bericht.
Restorative Effects of Natural Environment Experiences

The utility of different theoretical models of restorative experience was explored in a quasi-experimental field study and a true experiment. The former included wilderness backpacking and nonwilderness vacation conditions, as well as a control condition in which participants continued with their daily routines. The latter had urban environment, natural environment, and passive relaxation conditions. Multimethod assessments of restoration consisted of self-reports of affective states, cognitive performance, and, in the latter study, physiological measures. Convergent self-report and performance results obtained in both studies offer evidence of greater restorative effects arising from experiences in nature. Implications for theory, methodology, and design are discussed.
Human Attention in Digital Environments: The management of visual attention in graphic displays

This chapter presents an overview of several recent developments in vision science, and outlines some of their implications for the management of visual attention in graphic displays. These include ways of sending attention to the right item at the right time, techniques to improve attentional efficiency, and possibilities for offloading some of the processing typically done by attention onto nonattentional mechanisms. In addition it is argued that such techniques not only allow more effective use to be made of visual attention, but also open up new possibilities for human-machine interaction.
HIV-1gp120 Induces Neuronal Apoptosis through Enhancement of 4-Aminopyridine-Senstive Outward K+ Currents

Human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) usually occurs late in the course of HIV-1 infection and the mechanisms underlying HAD pathogenesis are not well understood. Accumulating evidence indicates that neuronal voltage-gated potassium (Kv) channels play an important role in memory processes and acquired neuronal channelopathies in HAD. To examine whether Kv channels are involved in HIV-1-associated neuronal injury, we studied the effects of HIV-1 glycoprotein 120 (gp120) on outward K+ currents in rat cortical neuronal cultures using whole-cell patch techniques. Exposure of cortical neurons to gp120 produced a dose-dependent enhancement of A-type transient outward K+ currents (IA). The gp120-induced increase of IA was attenuated by T140, a specific antagonist for chemokine receptor CXCR4, suggesting gp120 enhancement of neuronal IA via CXCR4. Pretreatment of neuronal cultures with a protein kinase C (PKC) inhibitor, GF109203X, inhibited the gp120-induced increase of IA. Biological significance of gp120 enhancement of IA was demonstrated by experimental results showing that gp120-induced neuronal apoptosis, as detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and caspase-3 staining, was attenuated by either an IA blocker 4-aminopyridine or a specific CXCR4 antagonist T140. Taken together, these results suggest that gp120 may induce caspase-3 dependent neuronal apoptosis by enhancing IA via CXCR4-PKC signaling.
Monoclonal phosphorylcholine antibody binds to beta-lipoprotein from different animal species

Previously published observations have demonstrated that murine antibody with specificity for phosphorylcholine (PC) binds to a variety of PC-containing polysaccharides and to human beta-lipoprotein. In this investigation it was found that monoclonal anti-PC antibody binds not only to human beta-lipoprotein, but also to beta-lipoprotein from the serum of all vertebrate species examined. beta-Lipoprotein from mouse reacted with autologous antibody; therefore, this antibody must be an autoantibody. This raises the question whether PC antibodies may exert unwanted effects after having been passively transferred or induced by PC-containing antigens, e.g., C-polysaccharide from pneumococci.
Intimate Relationships Affected by Breast Cancer: Interventions for Couples

A cancer diagnosis imposes significant emotional distress on a substantial proportion of patients and their partners, posing many challenges for both members of a couple. Facing a breast cancer diagnosis, couples may experience psychosocial distress, which might also affect their individual and dyadic functioning. Coping with cancer from a couple-based perspective as a dyadic stressor can profoundly influence psychosocial adjustment as well as individual and dyadic functioning of patients and spouses. Dyadic coping allows a better matching of needs, sharing of worries, and mutual support, resulting in higher relationship satisfaction. The aim of this article is to provide an overview of the issues faced by women diagnosed with breast cancer and their spouses, with particular emphasis on interventions for couples coping with cancer. The effectiveness of couple-based interventions is summarized with a critical discussion. For further research, a better understanding of the challenges couples coping with cancer may face and more insights on how to improve interventions for couples might facilitate improvements in the quality of cancer care.