Miracle-dz/UniFAR-FTUs huggingface dataset:
Unsmearing Vistlal Motion : Development of Long-Range Horizolltal Intrinsic Conllections

Human VlSlon systems integrate information nonlocally, across long spatial ranges. For example, a moving stimulus appears smeared when viewed briefly (30 ms), yet sharp when viewed for a longer exposure (100 ms) (Burr, 1980). This suggests that visual systems combine information along a trajectory that matches the motion of the stimulus. Our self-organizing neural network model shows how developmental exposure to moving stimuli can direct the formation of horizontal trajectory-specific motion integration pathways that unsmear representations of moving stimuli. These results account for Burr's data and can potentially also model ot.her phenomena, such as visual inertia.
IL-1 Induces IGF-Dependent Epithelial Proliferation in Prostate Development and Reactive Hyperplasia

A classically inflammatory mediator, interleukin-1, also functions during development in the prostate. Inflammatory Proliferation Both embryonic development and response to inflammation and injury are characterized by the proliferation of epithelial and progenitor cells and remodeling of the tissue stroma. Moreover, signaling pathways involved in development are reactivated during wound healing. Jerde and Bushman investigated the reverse scenario and found that the inflammatory cytokine interleukin-1α (IL-1α) stimulated epithelial cell growth in the developing prostate. Their data suggest that IL-1 family cytokines produced by epithelial cells act on stromal cells to stimulate insulin-like growth factor production, which in turn acts on epithelial cells to stimulate their proliferation. Noting that both inflammation and reactivation of developmental signaling pathways are associated with adenocarcinomas—another condition associated with epithelial and progenitor cell proliferation and stromal remodeling—the authors speculate that inflammatory mediators may play a conserved role in promoting epithelial proliferation in all of these conditions. Chronic inflammation and reactivation of developmental signaling pathways are both hallmarks of adenocarcinomas. However, developmental and inflammatory processes are generally thought of as distinct and are believed to represent separate paths to carcinogenesis. Here, we show that the inflammatory cytokine interleukin-1α (IL-1α) plays a critical role in prostate development by activating insulin-like growth factor (IGF) signaling; this process is reiterated during inflammatory reactive hyperplasia to elicit epithelial proliferation. The appearance of developmental signals during hyperplasia supports the hypothesis that reactivation of developmental signaling plays a role in the hyperplasic reaction to inflammation and suggests that there may be a conserved link between inflammatory signaling and canonical developmental pathways.
Serum corticoid levels relative to handling stress in Alaskan moose.

Blood serum 11-hydroxycorticosteroids were compared to visual evaluation of handling stress in Alaskan moose (Alces alces gigas) at the Kenai Moose Research Center (MRC). Moose were evaluated for handling excitability before and during handling when trapped, and were graded on a scale from 1 (not excited) to 5 (highly excited). There were significant differences in corticosteroid levels (a = 0.1) between each class comparison, except between classes 4 and 5, suggesting that this analysis provided a means to classify and compare other blood chemistry values from similarly stressed moose. Other factors may influence the 11-hydroxycorticosteroid levels, but handling stress had an overwhelming influence. Other methods to evaluate handling stress, such as body temperature, should also be considered, but when not feasible this method may be utilized.
Structural and immunological characterization of a biosurfactant produced by Bacillus licheniformis JF-2

Bacillus licheniformis JF-2 produces a very active biosurfactant under both aerobic and anaerobic conditions. We purified the surface-active compound to homogeneity by reverse-phase C18 high-performance liquid chromatography and showed that it is a lipopeptide with a molecular weight of 1,035. Amino acid analysis, fast atom mass and infrared spectroscopy, and, finally, 1H, 13C, and two-dimensional nuclear magnetic resonance demonstrated that the biosurfactant consists of a heterogeneous C15 fatty acid tail linked to a peptide moiety very similar to that of surfactin, a lipopeptide produced by Bacillus subtilis. Polyclonal antibodies were raised against surfactin and shown to exhibit identical reactivity towards purified JF-2 lipopeptide in competition enzyme-linked immunosorbent assays, thus providing further evidence for the structural similarity of these two compounds. Under optimal conditions, the B. licheniformis JF-2 biosurfactant exhibits a critical micelle concentration of 10 mg/liter and reduces the interfacial tension against decane to 6 x 10(-3) dyne/cm, which is one of the lowest interfacial tensions ever reported for a microbial surfactant.
Dorsal Root Ganglion Stimulation Used for the Treatment of Chronic Neuropathic Pain in the Groin: A Single‐Center Study With Long‐Term Prospective Results in 34 Cases

Chronic neuropathic pain in the groin is a severe condition and difficult to treat. Dorsal root ganglion stimulation (DRGS) covers discrete painful areas precisely with its stimulation power in comparison to spinal cord stimulation (SCS). It was our hypothesis that DRGS provides a long‐term relief of chronic groin pain over a period of more than three years.
Prognostic value of exercise pulmonary haemodynamics in pulmonary arterial hypertension

The aim of the study was to investigate the prognostic value of right heart catheterisation variables measured during exercise. 55 incident patients with idiopathic, familial or anorexigen-associated pulmonary arterial hypertension (PAH) underwent right heart catheterisation at rest and during exercise and 6-min walk testing before PAH treatment initiation. Patients were treated according to recommendations within the next 2 weeks. Right heart catheterisation was repeated 3–5 months into the PAH treatment in 20 patients. Exercise cardiac index decreased gradually as New York Heart Association (NYHA) functional class increased whereas cardiac index at rest was not significantly different across NYHA groups. Baseline 6-min walk distance correlated significantly with exercise and change in cardiac index from rest to exercise (r=0.414 and r=0.481, respectively; p<0.01). Change in 6-min walk distance from baseline to 3–5 months under PAH treatment was highly correlated with change in exercise cardiac index (r=0.746, p<0.001). The most significant baseline covariates associated with survival were change in systolic pulmonary artery pressure from rest to exercise and exercise cardiac index (hazard ratio 0.56 (95% CI 0.37–0.86) and 0.14 (95% CI 0.05–0.43), respectively). Change in pulmonary haemodynamics during exercise is an important tool for assessing disease severity and may help devise optimal treat-to-target strategies. Exercise cardiac index correlated with exercise capacity and was associated with long-term survival in PAH http://ow.ly/vG2bb
Students With Psychiatric Disabilities in Higher Education Settings

College students with psychiatric disabilities face multiple challenges. Judicial rulings under the Americans With Disabilities Act (ADA) of 1990 have generated outcomes that are sometimes more harmful than helpful. To reduce discrimination against persons with disabilities requires, among other things, a cultural shift in how psychiatric disabilities are viewed. This article examines (a) challenges that students with psychiatric disabilities face on higher education campuses; (b) the definition of disability under the ADA, with a focus on major life activities that may be substantially limited for people with psychiatric disabilities; (c) the implications of judicial rulings under the ADA for students with psychiatric disabilities; and (d) recommendations for accommodating students with psychiatric disabilities in higher education settings.
Cardamonin Inhibits Angiogenesis by mTOR Downregulation in SKOV3 Cells

Abstract The mammalian target of rapamycin is critical in hypoxia-triggered angiogenesis. Cardamonin inhibits proliferation of various cancer cells through suppressing the mammalian target of rapamycin. In this study, the antiangiogenic effect of cardamonin on CoCl2-mimicked hypoxic SKOV3 cells was investigated. Cardamonin exhibited an antiproliferative effect on normal and CoCl2-mimicked hypoxic SKOV3 cells. Messenger RNA expression of vascular endothelial growth factor was inhibited with cardamonin and rapamycin in SKOV3 cells under both conditions. However, cardamonin had little effect on the messenger RNA expression of hypoxia-inducible factor-α. Cardamonin inhibited the protein expression of hypoxia-inducible factor-1α, hypoxia inducible factor-2α, vascular endothelial growth factor, and the phosphorylation of mammalian target of rapamycin and ribosomal S6 kinase 1. Furthermore, angiogenesis induced by a medium of SKOV3 cells was reduced by cardamonin in a chicken embryo allantois membrane model. These findings suggest that cardamonin inhibits protein expression of hypoxia-inducible factor-α, and vascular endothelial growth factor, which was induced by CoCl2-mimicked hypoxia and this effect partially correlates with the mammalian target of rapamycin inhibition. Cardamonin might be a potential angiogenesis inhibitor for ovarian cancer therapy.
‘Won't you break free?’ An ethnography of music and the divine-human encounter at an Australian Pentecostal Church

This paper is based on ethnography of the ‘worship time’ at ‘Breakfree’ Church, a Pentecostal congregation in suburban Perth. I begin by exploring the ritualistic ways in which music is used to catalyse an ecstatic experience. Making use of the metaphor of ‘break free’, borrowed from a popular worship song, I demonstrate that music is used in deliberate ways to assist people in leaving behind the profane and encountering the sacred. Drawing on the thought of theologian Friedrich Schleiermacher and philosopher Paul Ricoeur, I explore the ways music facilitates and symbolises this experience. I demonstrate that for church members, the ecstatic divine-human encounter is the centre of their church worship and the antidote to difficult experiences such as grief or illness.
Dogs as Sentinels for Human Infection with Japanese Encephalitis Virus

Because serosurveys of Japanese encephalitis virus (JEV) among wild animals and pigs may not accurately reflect risk for humans in urban/residential areas, we examined seroprevalence among dogs and cats. We found that JEV-infected mosquitoes have spread throughout Japan and that dogs, but not cats, might be good sentinels for monitoring JEV infection in urban/residential areas.
Interfaces in the interpretation of mood alternation in L2 Spanish: Morpho-phonology, semantics and pragmatics

In this paper, we present the results of one written task testing the interpretation of mood choice in if-conditional constructions in L2 Spanish: a linguistic task of conditional utterances containing both regular and irregular indicative and subjunctive forms was completed by 48 L1 French and 40 L1 English speakers, and by an L1 Spanish control group (n = 35). Results show a similar pattern in the answers of both experimental groups despite the varying degree of similarity and disparity among the languages. We adopt a cognitive pragmatic perspective for the analysis of the results in connection with the various kinds of effects created by mood alternation in the constructions studied. Furthermore, in relation to current SLA debates (Lardiere 2008, 2009), our findings demonstrate that feature re-assembly in L2 Spanish is not trouble-free, as simple current feature accounts would advocate, even if those features exist in the learners’ L1.
Novel duplication in glypican‐4 as an apparent cause of Simpson–Golabi–Behmel syndrome

Novel Duplication in Glypican-4 as an Apparent Cause of Simpson–Golabi–Behmel Syndrome John Waterson,* Tracy L. Stockley, Summer Segal, and Mahin Golabi Division of Medical Genetics, Children’s Hospital & Research Center Oakland, Oakland, California Molecular Genetics Laboratory, The Hospital for Sick Children, Toronto, Ontario Division of Medical Genetics, University of California San Francisco, San Francisco, California Division of Medical Genetics, California Pacific Medical Center, San Francisco, California
Internet addiction: current status and implications for employees

The Internet is a new technology that has influenced the world and has provided many benefits to its users. At the same time, however, this influence has had negative ramifications. Some people are becoming preoccupied with the Internet, are unable to control their use of this technology, and are jeopardizing their employment and personal relationships. Internet addiction has been proposed as an explanation for uncontrollable, damaging use of this technology. Warning signs that an employee is having difficulty controlling his or her Internet use are reviewed. In addition, suggestions are proposed for managers to aid them in helping their employees with this problem.
Surveying the landscape: The first 15 years of Accounting History as an international journal

Accounting History celebrated a milestone at the end of 2010 – its first 15 years as an international refereed journal. This paper examines and provides commentary on the articles that have appeared in the journal from 1996 to 2010 using a series of thematic landscapes depicting dominant research trends and trajectories. Addressed are issues connected with the emergence of new themes, methods and topics, and the relative decline of other areas of historical accounting research. The investigation of these landscapes also provided the opportunity to explore and advance ideas concerning some unanswered calls and prospects in mapping the future content and profile of Accounting History.
Light treatment enhances photoreceptor survival in dystrophic retinas of Royal College of Surgeons rats.

PURPOSE To determine whether treatment with bright light elicits a protective response that enhances photoreceptor survival in Royal College of Surgeons (RCS) rats with inherited retinal degeneration. METHODS RCS rats were illuminated for 10 to 12 hours with 130 foot-candles (fc) of white or green light. Untreated littermates that were kept under low cyclic light levels were used as control subjects. Photoreceptor survival was determined by quantitative analysis of photoreceptor nuclei and ultrastructural assessment of cellular organization. Basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF) gene expression were determined at the mRNA and protein levels. RESULTS Treatments of RCS rats with a single dose of bright light on postnatal day 23 (P23) greatly enhanced photoreceptor survival. Ultrasturctural analysis revealed intact inner segments in light-treated retinas, whereas in untreated retinas only remnants of inner segments were observed. By P42, numerous viable nuclei were counted in the posterior retina of light-treated rats, whereas most of the remaining nuclei in untreated RCS rat retinas were highly pyknotic. At 2.5 days after treatment with a single dose of bright light, bFGF gene expression was significantly higher than in untreated RCS rat retinas. By P42, bFGF protein levels were still significantly higher in the treated retinas. CONCLUSIONS Exogenous bFGF has been shown to promote photoreceptor survival in the RCS rat retina. Thus, the increased bFGF expression that was measured in the light-treated RCS rat retinas may be a protective response to light stress, which supports the observed rescue of photoreceptors in light-treated RCS rat retinas.
You Are What You Wear: How Plus-Size Fashion Figures in Fat Identity Formation

Abstract This article examines the overlooked market of plus-size fashion and explores the ways in which the fashion industry neglects and marginalizes fat consumers. Faced with limited options in garments colloquially known as “plus-size” or “outsize” that are typically relegated to dark corners of clothing stores and are excluded from the pages of high fashion periodicals, the plus-size consumer lacks options in fashioning her self-identity. Under these circumstances, the role the fashion industry has played in further entrenching fat stigma in the collective consciousness and in abetting the processes of fat identity formation amongst plus-size consumers merits closer examination. Drawing upon the collected sartorial biographies of three self-identifying plus-size women, this article considers the ways in which fat identities are formed through the intimate practices of self-fashioning and via social channels such as shopping and fashion blogging, thereby bridging the fields of fat studies and fashion studies. It also takes into account issues of performativity and dress as a situated bodily practice. Through these case studies, the role the fashion industry plays in the processes of fat identity formation is brought to the fore, as are the complicated, creative, and sometimes subversive means through which fat women engage with plus-size fashion.
Is learning orientation in manufacturing and service firms different in India

Purpose – The purpose of this study is to assess employees' perceptions of their organizations' orientation towards learning in manufacturing and service firms.Design/methodology/approach – The Dimensions of the Learning Organization Questionnaire (DLOQ) developed by Marsick and Watkins, was administered to 235 executives working in the National Capital Region (NCR) in India. Regression analysis with the help of Eviews 5 was utilized to investigate the difference between the dimensions of DLOQ in both the sectors.Findings – Results suggest a significant impact of structural level dimension on a firm's financial and knowledge performance. Furthermore, no difference was observed between manufacturing and service sectors in context of a learning organization (LO). Research limitations/implications – Data were collected only from organizations operating in India's National Capital Region.Originality/value – This research fulfills the literature gap in the domain of LO. It applies the LO approach and the DLOQ t.
The relationship between children's home experiences and their mathematical skills on entry to school

This study describes the home experiences of six children who varied in their level of numerical understanding (either high or low) and in the socio‐economic status of their families (high or low). The study showed that children enter school with vastly different kinds of experiences with numbers and these seemed to be related to the extent of their knowledge of number concepts. Number experiences included domestic activities such as baking and shopping; games such as Snakes and Ladders, Strip‐Jack‐Naked, Poker, Monopoly, Bingo, and dominoes; experiences with time such as using calendars, clocks, and car speedometers; and experience handling calculators and money. The high scorers were characterized by exposure to a wide range of experiences involving numbers, a strong orientation towards numeracy by members of their families, and the opportunity to observe their mothers using numbers to solve everyday problems of their own. the low scorers, on the other hand, had few number experiences, an orientation by.
A Comparative Electrochemical Behaviour Study and Analytical Detection of the p-Nitrophenol Using Silver Solid Amalgam, Mercury, and Silver Electrodes

This work reports a comparative electrochemical behaviour study and p-nitrophenol analytical detection using silver solid amalgam, hanging dropping mercury, and silver electrodes. For this, square wave voltammetry was employed, where the analytical responses and the redox mechanisms could be compared for reduction processes of 4-nitrophenol by analysis of the voltammetric responses. The analytical performance of the electrode was evaluated and detection and quantification limits, recovery percentages, repeatability, and reproducibility for the silver solid amalgam and hanging dropping mercury electrodes presented similar values; the results presented for the silver electrode indicated worse analytical parameters than the other electrodes. The results indicate that the silver solid amalgam electrode can be considered a suitable tool and an interesting alternative for the analytical determination of 4-nitrophenol, as well as for the determination of other biological and environmentally interesting compounds that present analytical responses on mercury surfaces.
Physical Education as porn!

Background: This paper offers critical commentary on the culture of ‘performativity’ that has dominated educational discourse over the last 20 years, affecting the way in which researchers, teachers, pupils and parents think and act toward Physical Education and sport (PESP) in schools. It is a culture that, in the UK, is likely to intensify in the years ahead given Liberal-Conservative (Lib-Con) Government commitments to privatisation of public services, privileging the consumer, fostering greater diversity of provision, and freeing formal education of State and producer regulation. Purpose: To foster debate and reflection within the profession as to what Physical Education is for, what should be its guiding principles, and who should decide these things. Design: The paper offers informed polemic grounded in analyses of policy documents and personal research on Physical Education and Health over the last 20 or so years. Analyses: The paper re-stakes a claim for the importance of sociology in educational analysis and policy development, and the rediscovery of debate around their guiding principles. It was, after all, Durkheim (1956) who regarded as ‘the prime postulate of all pedagogical speculation that education is an eminently social thing in its origins as in its functions, and that, therefore, pedagogy depends on sociology more closely than any other science’ (Durkheim 1971, 91). How ironic, then, that, since the 1980s, the capacity of sociology to influence pedagogy has been so marginal, at a time when it has had so much to say. The paper speculates as to why this dislocation has occurred and with what consequences for what we know about teaching and how children learn and think about their body's value and worth. Conclusion: If performative culture is allowed to configure and define Physical Education, then it is likely to cultivate principles of thought and action somewhat akin to those defining Porn. If sociology or education research is to guide policy and practice in education away from the ‘pornification of PE’ (sic) it has to consider: what are the new rules of engagement between pedagogy and sociology? ; how and where are the voices of sociologists, pedagogues and researchers to be heard? How are closer allegiances between formal Education, Government and Media to be forged?