Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamical modelling of luminous and dark matter in 17 Coma early-type galaxies

Dynamical models for 17 early-type galaxies in the Coma cluster are presented. The galaxy sample consists of flattened, rotating as well as non-rotating early-types including cD and S0 galaxies with luminosities between MB = 18.79 and MB = 22.56. Kinematical long-slit observations cover at least the major and minor axis and extend to 1 4 reff. Axisymmetric Schwarzschild models are used to derive stellar mass-tolight ratios and dark halo parameters. In every galaxy the best fit with dark matter matches the data better than the best fit without. The statistical significance is over 95 percent for 8 galaxies, around 90 percent for 5 galaxies and for four galaxies it is not significant. For the highly significant cases systematic deviations between observed and modelled kinematics are clearly seen; for the remaining galaxies differences are more statistical in nature. Best-fit models contain 10-50 percent dark matter inside the half-light radius. The central dark matter density is at least one order of magnitude lower than the luminous mass density, independent of the assumed dark matter density profile. The central phase-space density of dark matter is often orders of magnitude lower than in the luminous component, especially when the halo core radius is large. The orbital system of the stars along the major-axis is slightly dominated by radial motions. Some galaxies show tangential anisotropy along the minor-axis, which is correlated with the minor-axis Gauss-Hermite coefficientH4. Changing the balance between data-fit and regularisation constraints does not change the reconstructed mass structure significantly: model anisotropies tend to strengthen if the weight on regularisation is reduced, but the general property of a galaxy to be radially or tangentially anisotropic, respectively, does not change. This paper is aimed to set the basis for a subsequent detailed analysis of luminous and dark matter scaling relations, orbital dynamics and stellar populations.
Comprehension and Retention: The Effect of Concrete Details and Causal Structure in Scientific Narrative

COMPREHENSION AND RETENTION: THE EFFECT OF CONCRETE DETAILS AND CAUSAL STRUCTURE IN SCIENTIFIC NARRATIVE Wendi M. Wilcken Department of Instructional Psychology and Technology Doctor of Philosophy The purpose of this study was to examine two of the salient elements of instructional narratives as a guide to instructional practice. The literature summarized in this report discusses the theoretical basis for narrative impact on comprehension and retention, enumerates and defines possible salient narrative elements from the literature, and examines the instructional impact of two of these elements: concrete details and causal structure. This is intended to help provide guidance to instructional designers and teachers who desire to use narrative in science instruction. Participants included 94 high school physics students. An experimental research design of 2 (Gender) x 2 (Concreteness) x 2 (Causal Structure) x 2 (Comprehension as within-subjects) ANCOVA was used to analyze the effects of the narrative elements. It was found that concrete details improved comprehension and retention but that causal structure had no statistically significant impact on comprehension or retention. There were no significant gender differences in comprehension or retention though there were twoand three-way interactions between the independent variables.
Case research as a methodology for industrial networks: a Realist apologia

Researchers most often employ a form of case research methodology when carrying out research into industrial networks. Previously the basis for this choice has rested on the obvious common sense match between case research and the kinds of situations that industrial network researchers have chosen to study. The paper describes four different epistemological orientations; positivism, constructivism, conventionalism and realism. It is argued that only realism has properties which ensure a match with the particular characteristics of case research and thus provide a justification for case base knowledge claims. The implications of, and constraints on, each of the other epistemological orientations for case research are described and, finally, the ramifications of realist based case research for programmes of research on industrial networks are described.
Novel Application of the Masson-Fontana Stain for Demonstrating Malassezia Species Melanin-Like Pigment Production In Vitro and in Clinical Specimens

ABSTRACT Melanin-like pigment produced in vitro and in vivo by Malassezia yeasts has not been described before. Masson-Fontana staining confirmed accumulation of black pigment on the cell walls of l-dihydroxyphenylalaline (l-DOPA)-cultured Malassezia species. Black pigment was also observed in cells and hyphae from hyperpigmented patient lesions with culture-confirmed pityriasis versicolor and seborrheic dermatitis.
Impact of Mechanical Trauma on Matrix and Cells

Posttraumatic arthritis is one of the most common causes of secondary osteoarthritis. The contribution of cell death to matrix degradation has not been characterized fully. The current study was designed to determine the effect of mechanical injury on chondrocyte viability and matrix degradation. Full-thickness bovine and human cartilage explants, 5 mm in diameter were subjected to mechanical loads representative of traumatic joint injury. Glycosaminoglycan release and percent apoptotic cells were measured. Unilateral patellas in eight anesthetized rabbits were subjected to an impact load. Rabbits were euthanized at 96 hours after injury and patellar cartilage was harvested for analysis. The effect of a pan-caspase inhibitor, z-VAD.fmk [benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone] in preventing chondrocyte apoptosis in human articular cartilage explants was determined. A significant increase in the number of apoptotic cells was observed in response to mechanical loading. The mean in vivo apoptotic rates were 1% in control rabbits and 15% in impacted patellas. Caspase inhibition reduced chondrocyte apoptosis from 34% to 25% after mechanical injury and was associated with reduction in glycosaminoglycan release. Mechanical injury induces chondrocyte apoptosis that is sensitive to pharmacologic inhibition. This identifies a new approach to limit traumatic cartilage injury and the subsequent development of secondary osteoarthritis.
Linking Global Citizenship Education and Education for Democracy through Social Justice: What can we learn from the perspectives of teacher - education candidates

The respective projects of education for global citizenship and Education for Democracy are inherently intertwined; the richness and salience of one is dependent on the expression of the other. While both of these ideals are varied and broad in definition, they are each gaining prominence in theoretical debates, in policy development, and at the school level, where the implementation of (formal) education takes place. In this article we examine the construction of meanings ascribed to Global Citizenship Education, survey its position in the curriculum today, and connect it with Education for Democracy. Structured around the findings of a multi-faceted study with teacher-education candidates in education programs at a university in Ontario, Canada, this article uses data that demonstrates how Education for Democracy, like Global Citizenship Education, is largely perceived in and between a binary of mainstream and critical orientations. The findings of our study highlight a passive, mainstream, or neutralized understanding of democracy, in which research participants made little or no mention of, or linkage to, equity or social justice to democracy. This paper argues that global citizenship, Education for Democracy, and social justice are interlinked, and necessary to create a more just society for all. Further, we 1 This paper is part of, and has benefited from funding from, a Social Sciences and Humanities Research of Canada (SSHRC) project entitled Democracy, Political Literacy and Transformative Education (DPLTE), which is led by the lead author, who is the Principal Investigator. The two co-authors are research assistants on this project. JGCEE, Vol. 4, No. 1, October 2014 • 2 find that central descriptors of critical perspectives have been coopted or conflated, resulting in reduced meaning. To add a practical element to this conversation, we present six proposals to develop and bolster the critical facets of Education for Democracy and global citizenship, including addressing the local in global, welcoming conflict in learning sites, and highlighting the primacy of equity in each approach.
Danish register-based study on the association between specific cardiovascular drugs and fragility fractures

Objective To determine whether drugs used in treatment of cardiovascular diseases (CVD-drugs), including hypertension, increase the risk of fragility fractures in individuals above the age of 65 years. Design Retrospective nationwide cohort study. Setting Danish nationwide national registers. Participants All individuals in Denmark ≥65 years who used specified CVD-drugs in the study period between 1999 and 2012. Main outcomes measures Time-dependent exposure to CVD-drugs (nitrates, digoxin, thiazides, furosemide, ACE inhibitors, angiotensin receptor antagonists, β-blockers, calcium antagonists and statins) was determined by prescription claims from pharmacies. The association between use of specific CVD-drugs and fragility fractures was assessed using multivariable Poisson regression models, and adjusted incidence rate ratios (IRRs) were calculated. Results Overall, 1 586 554 persons were included, of these 16.1% experienced a fall-related fracture. The multivariable Poisson regression analysis showed positive associations between fracture and treatment with furosemide, thiazide and digoxin. IRRs during the first 14 days of treatment were for furosemide IRR 1.74 (95% CI 1.61 to 1.89) and for thiazides IRR 1.41 (1.28 to 1.55); IRR during the first 30 days of treatment with digoxin was 1.18 (1.02 to 1.37). Conclusions Use of furosemide, thiazides and digoxin was associated with elevated rates of fragility fractures among elderly individuals. This may warrant consideration when considering diuretic treatment of hypertension in elderly individuals.
Immunopathology of rejection: do the rules of solid organ apply to vascularized composite allotransplantation?

Purpose of reviewAs both the number of vascularized composite allotransplants (VCAs) recipients and the duration of their follow-up are limited, immunopathology of VCA rejection remains incompletely understood. VCAs have several immunological peculiarities, which make inaccurate a direct extrapolation of all rules established for solid organs. Recent findingsDespite their bone marrow content, VCA do not induce chimerism in recipient and are therefore not spontaneously tolerated. Skin compartment of VCA contains a high density of antigen-presenting cells (APCs), some with self-renewal capacity. Donor APCs are responsible for continuous direct allosensitization of recipient's T cells that explains the high incidence of skin T-cell-mediated rejection and their occurrence beyond 1 year.Regenerative capability of the skin prevents the development of chronic rejection of this compartment as long as immunosuppression is maintained. In contrast, VCA can develop graft arteriosclerosis, which could be because of T cell and/or chronic antibody-mediated rejection (AMR). VCA recipients can indeed develop donor-specific antibodies (DSA). Whether DSA can also trigger acute AMR of VCA remains to be clarified. SummaryA better understanding of the specificities of the immunopathology of VCA rejection should pave the way for the rationalization of immunosuppressive strategies aiming at optimizing long-term outcome.
A Mind-Reader Does Not Always Have Deontological Moral Judgments and Prosocial Behavior: A Developmental Perspective

The rationalistic theories of morality emphasize that reasoning plays an important role in moral judgments and prosocial behavior. Theory of mind as a reasoning ability in the mental domain has been considered a facilitator of moral development. The present study examined whether theory of mind was consistently positively associated with morality from middle childhood to late adulthood. Two hundred and four participants, including 48 elementary school children, 45 adolescents, 62 younger adults, and 49 older adults, completed theory of mind, moral judgment and prosocial behavior tasks. Theory of mind was measured with strange stories that tapped into an understanding of lies, white lies, double bluffs, irony, and persuasion. Moral judgments were measured with variants of the trolley dilemma. Prosocial behavior was measured through participants' performance in an interactive situation in which a helping request was made. The results indicated specific rather than similar developmental trajectories of theory of mind, moral judgments, and prosocial behavior. There was a quadratic trend in theory of mind, a combination of quadratic and cubic trends in deontological moral judgments and a linear decline in helping behavior. It is thus suggested that theory of mind may not be associated with morality in an unchanging way during development. Further results indicated that theory of mind and deontological moral judgments were negatively correlated for children, adolescents, and older adults but positively correlated for younger adults. Theory of mind and helping behavior were positively correlated for children but negatively correlated for adolescents. However, the relationships disappeared in adulthood. In sum, the present study reveals that theory of mind may be a nice tool for its facilitation of deontological moral judgments and prosocial behavior, but it may also be a nasty tool for its blocking of deontological moral judgments and prosocial behavior. Moreover, theory of mind may be a permanent tool for moral judgment development but a temporary tool for prosocial behavior development. Thus, the present study enriches the rationalistic theories of morality from a developmental perspective. Different relationships between theory of mind and morality from middle childhood to late adulthood are discussed.
The moderating role of Hofstede’s cultural dimensions in the customer-brand relationship in China and India

Purpose – The purpose of this paper is to enhance the understanding of customer-brand relationships in the international marketplace, and empirically investigates and compares the customer-brand relationship development process between Indian and Chinese markets. In detail, four out of Hofstede’s original five national culture dimensions were adopted as moderators in the process of customer-brand relationship development between two markets. Design/methodology/approach – To test hypotheses, responses from 539 Indian and 400 Chinese mobile phone consumer samples were achieved, and the proposed model was estimated by using structural equations based on the partial least squares algorithm. Findings – The results demonstrate that utilitarian value and brand affect play a significant role in building brand loyalty for Chinese consumers, while hedonic value and perceived risk contribute more in building brand loyalty for Indian consumers. Research limitations/implications – This study indicated that the cultura.
The association between glomerular filtration rate and left ventricular function in two independent community-based cohorts of elderly

Background The cardiorenal syndrome, the detrimental bi-directional interplay between symptomatic heart failure and chronic kidney disease, is a major clinical challenge. Nonetheless, it is unknown if this interplay begins already at an asymptomatic stage. Therefore we investigated whether the glomerular filtration rate (GFR) is associated with left ventricular function in participants free from clinical heart failure and with a left ventricular ejection fraction (LVEF) >40% and with pre-specified sub-group analyses in individuals with a GFR >60 mL/min/m2. Methods Two independent community-based cohorts were used; the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n = 911; 50% women; mean age: 70 years) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 538; mean age: 71 years). We investigated cross-sectional association between cystatin C-based GFR (estimated glomerular function [eGFR]) and systolic (LVEF), diastolic- (isovolumic relaxation time [IVRT]) and global left ventricular function (myocardial performance index [MPI]) determined by echocardiography. Results In both PIVUS and ULSAM, higher eGFR was significantly associated with higher LVEF (P = 0.004 [PIVUS] and P = 0.005 [ULSAM]). In PIVUS, higher eGFR was significantly associated with lower IVRT (P = 0.001) and MPI (P = 0.006), in age- and sex-adjusted models. After further adjustment for cardiovascular risk factors, the association between higher eGFR and higher LVEF was still statistically significant (P = 0.008 [PIVUS] and P = 0.02 [ULSAM]). In PIVUS, the age- and sex-adjusted association between eGFR and left ventricular function was similar in participants with eGFR >60 mL/min/m2. Conclusions Our data suggest that the interplay between kidney and heart function begins prior to the development of symptomatic heart failure and kidney disease.
5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study

Background and aims: The objective of this study was to evaluate the risk of colorectal cancer (CRC) in patients taking aminosalicylates (5-ASA) for inflammatory bowel disease (IBD). Methods: The General Practice Research Database (GPRD) which contains the primary care records of five million people in the UK was used to identify users of mesalazine, balsalazide, olsalazine, or sulfasalazine with a history of IBD. In a nested case control analysis, each incident CRC case with any use of a 5-ASA in the six months before the CRC diagnosis was matched by age, sex, and calendar time to six control patients who were also currently using a 5-ASA. Patients were then classified according to regularity of use. The analysis was controlled for body mass index, IBD duration, history of colorectal polyps, use of non-steroidal anti-inflammatory drugs, paracetamol, aspirin, immunosuppressants, oral and rectal glucocorticoids, prior gastrointestinal hospitalisation, recorded colonoscopy, and number of visits to the general practitioner for IBD symptoms in the 6–24 months before diagnosis. Results: The study population included 18 969 patients, of whom 100 had developed CRC during 5-ASA exposure. Most of these cases had a history of ulcerative colitis (76 patients). In the case control analysis, regular users, defined as having six or more 5-ASA prescriptions in the previous 12 months, were found to have a decreased risk of CRC compared with irregular users (crude odds ratio (OR) 0.7 (0.44–1.03); adjusted OR 0.60 (0.38–0.96)). Regular users of sulfasalazine with 6–12 prescriptions before had an adjusted OR of 0.95 (0.22–4.11); with 13–30 prior prescriptions this was 0.41 (0.14–1.20) and with >30 prior prescriptions this was 0.77 (0.37–1.60). For mesalazine users, these values were 1.13 (0.49–2.59), 0.30 (0.11–0.83), and 0.31 (0.11–0.84), respectively. Conclusion: These results show that regular 5-ASA use is associated with some reduction in the risk of CRC developing in ulcerative colitis.
Low counts of γδ T cells in peritumoral liver tissue are related to more frequent recurrence in patients with hepatocellular carcinoma after curative resection.

OBJECTIVES TCR- gamma-delta + T cells (γδ T cells) are non-conventional T lymphocytes that can recognize and eradicate tumor cells. Our previous studies showed that infiltration and function of γδT cells were substantially attenuated in hepatocellular carcinoma (HCC). However, their prognostic value was not clarified. METHODS The association between γδ T cells and the clinical outcomes was determined by immunohistochemistry (IHC) in a HCC patient cohort (n = 342). RESULTS Immunohistochemistry showed decreased infiltration of γδ T cells in tumoral tissues compared with paired peritumoral tissues. The counts of γδ T cells in peritumoral tissues were negatively correlated with tumor size (P = 0.005). Survival analysis showed that the levels of peritumoral γδ T cells were related to both time to recurrence (TTR) and overall survival (OS) (P = 0.010 and P = 0.036, respectively) in univariate analysis, and related to TTR in multivariate analysis (P = 0.014, H.R. [95% CI] = 0.682 [0.502-0.927]). Furthermore, the level of peritumoral γδ T cells showed independent prognostic value for TTR in Barcelona Clinic Liver Cancer (BCLC) stage A patients (P = 0.038, H.R. [95% CI] = 0.727 [0.537-0.984]). However, tumoral γδ T cells did not show independent prognostic value for either TTR or OS in HCC patients. CONCLUSIONS Low counts of γδ T cells in peritumoral liver tissue are related to a higher incidence of recurrence in HCC and can predict postoperative recurrence, especially in those with early-stage HCC.
Pre-Task Prefrontal Activation during Cognitive Processes in Aging: A Near-Infrared Spectroscopy Study

Purpose Cognitive processing generally deteriorates as people age. Recent neuroimaging studies have shown that the prefrontal cortex (PFC) is involved in human-specific behavior, such as preparing for future actions and prospective memory; hence, the PFC may be voluntarily activated even during the “resting” condition that precedes task execution. The purpose of the present study was to investigate changes in voluntary pre-task activation as a result of aging using a paradigm that includes a longer intertrial interval (e.g., 30 sec) than has been used in previous studies. Methods A total of 120 cognitively normal adults (young: 60, old: 60) participated in this near-infrared spectroscopy (NIRS) study. All subjects performed 6 repetitions of the working memory task, which included a 30 sec resting period and a 28.8 sec task period. The resting period was divided into baseline and pre-task (preT) periods, and the task period was divided into early easy task (eT) and late difficult task (dT) periods. We then normalized the data, analyzed the magnitude of task-related NIRS responses in each period and compared the results between groups using an analysis of variance test. Results Statistical analyses revealed a significant interaction between group × optode location × period, in which hemodynamic responses in the PFC during the preT period were smaller in the elderly in than young adults. By contrast, during the task period, the hemodynamic responses were higher in the lateral PFC in the elderly than in young adults. Spearman's rank correlation analysis showed a positive correlation between hemodynamic changes during the preT period in the PFC and correct answer ratios in both groups. Conclusions These findings suggest that more pre-task activation in the anterior PFC is related to better cognitive performance in humans. Thus, a reduction in this activation might partly explain cognitive decline in the elderly.