Miracle-dz/UniFAR-FTUs huggingface dataset:
Flexible LDPC Decoder Design for Multigigabit-per-Second Applications

Low-density parity-check (LDPC) codes are one of the most promising error-correcting codes approaching Shannon capacity and have been adopted in many applications. However, the efficient implementation of high-throughput LDPC decoders adaptable for various channel conditions still remains challenging. In this paper, a low-complexity reconfigurable VLSI architecture for high-speed LDPC decoders is presented. Shift-LDPC codes are incorporated within the design and have shown not only comparable decoding performance to computer-generated random codes but also high hardware efficiency in high-speed applications. The single-minimum Min-Sum decoding scheme and the nonuniform quantization scheme are explored to reduce the complexity of computing core and the memory requirement. The well-known Benes network is employed to construct the configurable permutation network to support multiple shift-LDPC codes with various code parameters. The ASIC implementation results of an (8192, 7168) (4, 32)-regular shift-LDPC decoder demonstrate a maximum decoding throughput of 3.6 Gbits/s at 16 iterations, which outperforms the state-of-the-art design for high-speed flexible LDPC decoders by many times with even less hardware.
Falls Reduction and Exercise Training in an Assisted Living Population

Multicomponent exercise programs are currently an efficacious fall prevention strategy among community dwelling older adults although research documents differential falls susceptibility among frail older adults. This study aimed to examine the association between the Boston FICSIT (Frailty and Injuries: Cooperative Studies of Intervention Techniques) exercise program (the original exercise program to demonstrate that nursing home residents can increase strength) and falls incidents in an assisted living community. A descriptive cross-sectional study matched exercise charts for frequency and duration of training with number of reported fall incidents. Among 39 participants, 33% (n = 13) reported a fall incident. Adults without a fall history reported more time in aerobic (26.30 versus 20.00, P value = 0.71) and strength (1.50 versus 0.50, P value = 0.01) training sessions compared to those with a fall history. Multivariate models adjusting for covariates illustrated a significant protective association between strength training and fall incidents (OR = 0.25; 95% CI = 0.07, 0.85). In this cross-sectional study, this progressive resistance exercise training program into an assisted living population was associated with a decrease in the number of fall incidents.
Integrating Association Rule Mining with Relational Database Systems : Alternatives and Implications

Data mining on large data warehouses is becoming increasingly important. In support of this trend, we consider a spectrum of architectural alternatives for coupling mining with database systems. These alternatives include: loosecoupling through a SQL cursor interface; encapsulation of a mining algorithm in a stored procedure; caching the data to a le system on-they and mining; tight-coupling using primarily user-de ned functions; and SQL implementations for processing in the DBMS. We comprehensively study the option of expressing the mining algorithm in the form of SQL queries using Association rule mining as a case in point. We consider four options in SQL-92 and six options in SQL enhanced with object-relational extensions (SQL-OR). Our evaluation of the di erent architectural alternatives shows that from a performance perspective, the Cache-Mine option is superior, although the performance of the SQL-OR option is within a factor of two. Both the Cache-Mine and the SQL-OR approaches incur a higher storage penalty than the loose-coupling approach which performance-wise is a factor of 3 to 4 worse than Cache-Mine. The SQL-92 implementations were too slow to qualify as a competitive option. We also compare these alternatives on the basis of qualitative factors like automatic parallelization, development ease, portability and inter-operability.
Efficacy and tolerability of long-term rilmenidine treatment in hypertensive diabetic patients. A retrospective analysis of a general practice study.

INTRODUCTION Rilmenidine is a centrally acting antihypertensive which differs from the other representatives of this class by its very high specificity for the imidazoline I1 receptors and its good tolerability. Recent studies have shown rilmenidine improves glucose tolerance and reduces micro-albuminuria in patients with diabetes mellitus. METHODOLOGY The evidence of these potentially favorable characteristics encouraged a secondary retrospective analysis of a subgroup of 2738 diabetic patients included in a previous long-term open study of rilmenidine alone, or in combination with other classes of antihypertensives. RESULTS The antihypertensive efficacy of rilmenidine demonstrated previously in controlled studies was confirmed during the 12-month follow-up. In addition, favorable effects of drug treatment on fasting blood glucose and plasma triglyceride levels were consistent with an improvement in glucose and lipid metabolism during treatment. The profile of adverse events was similar to that observed in the nondiabetic population, the occurrence of postural hypotension being observed in <1% of patients and not necessitating any withdrawals from the study. CONCLUSION Diabetic hypertensive patients frequently require the use of multiple medications and consideration of the metabolic interactions between treatments. The results of this retrospective analysis support the use of rilmenidine in patients with hypertension and diabetes mellitus and should encourage the conduct of controlled trials of cardiovascular and renal protection and outcome with this compound.
CBIR in Distributed Databases using a Multi-Agent System

Information retrieval techniques have to face both the growing amount of data to be processed and the "natural"' distribution of these data over the network. Hence, we introduce in this paper a new architecture for image retrieval in distributed image databases, based on multi-agent, systems. Our system, inspired by "ant-agents", uses labels provided by the user for learning both the searched category of images and die path to the most relevant databases. We then show how effective can be our architecture on a generalist image database network.
Aortic atheromatous lesions developed in APA hamsters with streptozotocin induced diabetes: a new animal model for diabetic atherosclerosis. 1. Histopathological studies.

To develop an adequate animal model for atherosclerosis in large vessels of patients with diabetes, i.e. diabetic macroangiopathy, we induced diabetes in APA hamsters with a single injection of streptozotocin (SZ) and examined the aorta histopathologically and immunohistochemically. As a result, hyperglycemia and hyperlipidemia were continuously observed for 26 weeks after the SZ injection (WAI) in APA hamsters. Fatty streaks characterized by a subendothelial accumulation of many foam cells were observed, limited to the aortic arches as early as 6 WAI. In addition to larger fatty streaks developing with the duration of diabetes, fibrous plaques and plaques containing calcium deposits or cholesterol clefts developed at 26 WAI. These lesions are generally similar to the atheromatous lesions developed in humans. Moreover, depositions of apolipoprotein E and advanced glycation end-products immunohistochemically detected in the lesions were very similar to those found in humans. The diabetic APA hamster is therefore considered to be a useful model for studying the formation of atheromatous lesions in diabetic patients.
Therapeutics , Targets , and Chemical Biology ZNF 668 Functions as a Tumor Suppressor by Regulating p 53 Stability and Function in Breast Cancer

Genome-wide sequencing studies in breast cancer have recently identified frequent mutations in the zinc finger protein 668 (ZNF668), the function of which is undefined. Here, we report that ZNF668 is a nucleolar protein that physically interacts with and regulates p53 and its negative regulator MDM2. Through MDM2 binding, ZNF668 regulated autoubiquitination of MDM2 and its ability to mediate p53 ubiquitination and degradation. ZNF668 deficiency also impaired DNA damage–induced stabilization of p53. RNA interference– mediated knockdown of ZNF668 was sufficient to transform normal mammary epithelial cells. ZNF668 effectively suppressed breast cancer cell proliferation in vitro and tumorigenicity in vivo. Taken together, our studies identify ZNF668 as a novel breast tumor suppressor gene that functions in regulating p53 stability. Cancer Res; 71(20); 6524–34. 2011 AACR.
implicated in myeloid leukemia Transcription profiling of C / EBP targets identifies Per 2 as a gene

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Rat Mesenchymal Stromal Cells Inhibit T Cell Proliferation but Not Cytokine Production Through Inducible Nitric Oxide Synthase

Mesenchymal stromal cells (MSC) have important immunomodulatory properties, they inhibit T lymphocyte allo-activation and have been used to treat graft-versus-host disease. How MSC exert their immunosuppressive functions is not completely understood but species specific mechanisms have been implicated. In this study we have investigated the mechanisms for rat MSC mediated inhibition of T lymphocyte proliferation and secretion of inflammatory cytokines in response to allogeneic and mitogenic stimuli in vitro. MSC inhibited the proliferation of T cells in allogeneic mixed lymphocyte reactions and in response to mitogen with similar efficacy. The anti-proliferative effect was mediated by the induced expression of nitric oxide (NO) synthase and production of NO by MSC. This pathway was required and sufficient to fully suppress lymphocyte proliferation and depended on proximity of MSC and target cells. Expression of inducible NO synthase by MSC was induced through synergistic stimulation with tumor necrosis factor α and interferon γ secreted by activated lymphocytes. Conversely, MSC had a pronounced inhibitory effect on the secretion of these cytokines by T cells which did not depend on NO synthase activity or cell contact, but was partially reversed by addition of the cyclooxygenase (COX) inhibitor indomethacin. In conclusion, rat MSC use different mechanisms to inhibit proliferative and inflammatory responses of activated T cells. While proliferation is suppressed by production of NO, cytokine secretion appears to be impaired at least in part by COX-dependent production of prostaglandin E2.
Efficient cryptographic protocols preventing man-in-the-middle attacks

In the analysis of many cryptographie protocole, it is useful to distinguish two classes of attacks: passive attacks in which an adversary eavesdrops on messages sent between honest users and active attacks (i.e, “man-in-the-middle” attacks) in which—in addition to eavesdropping—the adversary inserts, deletes, or arbitrarily modifies messages sent from one user to another. Passive attacks are well characterized (the adversary's choices are inherently limited) and techniques for achieving security against passive attacks are relatively well understood. Indeed, cryptographers have long focused on methods for countering passive eavesdropping attacks, and much work in the 1970's and 1980's has dealt with formalizing notions of security and providing provably-secure solutions for this setting. On the other hand, active attacks are not well characterized and precise modeling has been difficult. Few techniques exist for dealing with active attacks, and designing practical protocols secure against such attacks remains a challenge. This dissertation considers active attacks in a variety of settings and provides new, provably-secure protocols preventing such attacks. Proofs of security are in the standard cryptographie model and rely on well-known cryptographie assumptions. The protocols presented here are efficient and practical, and may find application in real-world systems.
Efficient targeted DNA editing and replacement in Chlamydomonas reinhardtii using Cpf1 ribonucleoproteins and single-stranded DNA

Significance Our findings establish a method of efficient, targeted genome editing in Chlamydomonas reinhardtii. We demonstrate an approach to bypass inefficient gene targeting via homologous recombination and achieve homology-directed DNA replacement in C. reinhardtii. In addition, we report CRISPR/Cpf1-mediated DNA editing efficiencies being boosted 500-fold through the use of single-stranded oligodeoxynucleotides (ssODNs) as repair templates. It remains to be determined whether Cpf1-induced staggered DNA cleavage enhances ssODN-mediated gene editing in a wider range of species and whether the underlying repair pathway(s) responsible is more broadly conserved. The green alga Chlamydomonas reinhardtii is an invaluable reference organism to research fields including algal, plant, and ciliary biology. Accordingly, decades-long standing inefficiencies in targeted nuclear gene editing broadly hinder Chlamydomonas research. Here we report that single-step codelivery of CRISPR/Cpf1 ribonucleoproteins with single-stranded DNA repair templates results in precise and targeted DNA replacement with as much as ∼10% efficiency in C. reinhardtii. We demonstrate its use in transgene- and selection-free generation of sequence-specific mutations and epitope tagging at an endogenous locus. As the direct delivery of gene-editing reagents bypasses the use of transgenes, this method is potentially applicable to a wider range of species without the need to develop methods for stable transformation.
Acute hand burns in children: management and long-term outcome based on a 10-year experience with 698 injured hands.

OBJECTIVE To document long-term results associated with an coordinated plan of care for acutely burned hands in children. SUMMARY AND BACKGROUND DATA Optimal hand function is a crucial component of a high-quality survival after burn injury. This can be achieved only with a coordinated approach to the injuries. Long-term outcomes associated with such a plan of care have not been previously reported. METHODS Over a 10-year period, 495 children with 698 acutely burned hands were managed at a regional pediatric burn facility; 219 children with 395 injured hands were followed in the authors' outpatient clinic for at least 1 year and an average of >5 years. The authors' approach to the acutely burned hand emphasizes ranging and splinting throughout the hospital stay, prompt sheet autograft wound closure as soon as practical, and the selective use of axial pin fixation and flaps. Long-term follow-up, hand therapy, and reconstructive surgery are emphasized. RESULTS Normal functional results were seen in 97% of second-degree and 85% of third-degree injuries; in children with burns involving underlying tendon and bone, 70% could perform activities of daily living and 20% had normal function. Reconstructive hand surgery was required in 4.4% of second-degree burns, 32% of third-degree burns, and 65% of those with injuries involving underlying bone and tendon. CONCLUSIONS When managed in a coordinated long-term program, the large majority of children with serious hand burns can be expected to have excellent functional results.
Sequelae to pneumoencephalography

Fifty patients were examined clinically and neurologically for seven days after pneumoencephalography. Headache was present in 78%, neck stiffness in 34%, pyrexia in 38%, vomiting in 34%, tachycardia in 74%, a change in the level of consciousness in 18%, and abnormal neurological signs in 30%. Of the 13 patients with epilepsy, there was an increased frequency of seizures in four, associated with increased EEG epileptiform activity in three. EEG abnormality either appeared or increased in 74% of cases on the second day after the air study. A mechanism for the production of these sequelae is proposed. It is concluded that these findings indicate that in most cases an organic brain syndrome follows pneumoencephalography.
Determining Optimal Sensing Time for Multi-Radio Multi-Channel Cognitive Radios

Fast and e-cient spectrum sensing is vital for multi- radio multi-channel cognitive radio (CR) networks where unlicensed secondary users (SUs) have to sense and opportunistically transmit on multiple spectrum bands without causing any harmful interference to the licensed primary users (PUs) of those spectrum bands. Accordingly, this paper presents a smart, practical and e-cient wideband spectrum sensing scheme based on an optimal sensing stop policy that aims to optimize SU throughput while adhering to the PU interference constraints. Unlike existing work, this scheme is smart because in determining the best time for the multi-transmitter SU to stop sensing and start data transmission based on the channels that have been sensed idle, this scheme explicitly takes into consideration the number of transmitters on the SU; so-called N-transmitters constrained SU. Further, we formulate and solve the optimal sensing stopping problem. The numerical and simulation results presented verify the e-ciency of the proposed sensing scheme.
Second Life: game, simulator, or serious game?

Ten years after being launched in 2003, it is still a matter of discussion if Second Life (SL) is a virtual world, a computer game, a shopping site or a talker (communication software based on a MUD). This article reports on an exploratory case study conducted to analyze the Second Life (SL) environment and determine into which of training simulators, games, simulation games, or
The role of vitamin D in allergic rhinitis

Recent studies suggest that vitamin D is related to allergic rhinitis (AR). In this review, we first discuss the physiology and metabolism of vitamin D, then we review the function of vitamin D in the immune system, and above all, we highlight the current research regarding the role of vitamin D in AR. Finally, we find that there are both experimental and clinical studies showing that vitamin D is associated with AR, although the results are not consistent and even conflicting. Evidences from those clinical studies show a slightly tendency that serum vitamin D level might be inversely associated with the risk of AR. Meanwhile, it seems that gender and age may influence the relationship between vitamin D and AR. However, because of the heterogeneity in defining AR, differences in study design and so on, all these findings need to be confirmed by further studies. Additional clinical studies as well as experimental research are needed to better understand how vitamin D influences AR.
Self–Other Agreement and Assumed Similarity in Neuroticism, Extraversion, and Trait Affect

Trait Negative Affect (NA) and Positive Affect (PA) are strongly associated with Neuroticism and Extraversion, respectively. Nevertheless, measures of the former tend to show substantially weaker self–other agreement—and stronger assumed similarity correlations—than scales assessing the latter. The current study separated the effects of item content versus format on agreement and assumed similarity using two different sets of Neuroticism and Extraversion measures and two different indicators of NA and PA (N = 381 newlyweds). Neuroticism and Extraversion consistently showed stronger agreement than NA and PA; in addition, however, scales with more elaborated items yielded significantly higher agreement correlations than those based on single adjectives. Conversely, the trait affect scales yielded stronger assumed similarity correlations than the personality scales; these coefficients were strongest for the adjectival measures of trait affect. Thus, our data establish a significant role for both content and format in assumed similarity and self–other agreement.
A Precursor of the Monthly-Mean Large-Scale Atmospheric Circulation Anomalies over the North Pacific

The North Pacific shows dominant monthly-mean largescale atmospheric circulation anomalies, even after removing the variabilities of the Northern Hemisphere annular mode and the El Niño/Southern Oscillation. This work examines the precursors and their development for these residual anomalous circulations by applying objective reanalysis data to empirical orthogonal function (EOF) analysis. The first EOF mode (EOF1) features a monopole, while a dipole characterizes the second EOF mode (EOF2) over the North Pacific. Transient eddies (TEs) interactively induce the two EOF modes. The precursors of EOF1 and EOF2 are detected in the anomalies of one month earlier; these are the systematic zonal bands detected in surface temperature and baroclinic instability (BI) in the lower troposphere over Eurasia and North America. The BI anomalies further extend into the central North Pacific at different latitudes between EOF1 and EOF2. Coherent zonal bands also appear in the geopotential height anomalies of upper troposphere. Such zonal bands reflect the ovalization of Arctic circumpolar circulation with different continent-ward shifts of the longer axis. The direction of this shift determines which EOF mode develops by the following month through the guided activation of TEs at a designated latitude over the North Pacific. (Citation: Tomita, T., and T. Yamaura, 2017: A precursor of the monthly-mean large-scale atmospheric circulation anomalies over the North Pacific. SOLA, 13, 85−89, doi:10.2151/sola.2017016.)
Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling

Multiple sclerosis is an autoimmune disease of the CNS resulting in degeneration of myelin sheaths and loss of oligodendrocytes, which means that protection and electrical insulation of axons and rapid signal propagation are impaired, leading to axonal damage and permanent disabilities. Partial replacement of lost oligodendrocytes and remyelination can occur as a result of activation and recruitment of resident oligodendroglial precursor cells. However, the overall remyelination capacity remains inefficient because precursor cells often fail to generate new oligodendrocytes. Increasing evidence points to the existence of several molecular inhibitors that act on these cells and interfere with their cellular maturation. The p57kip2 gene encodes one such potent inhibitor of oligodendroglial differentiation and this study sheds light on the underlying mode of action. We found that subcellular distribution of the p57kip2 protein changed during differentiation of rat, mouse, and human oligodendroglial cells both in vivo and in vitro. Nuclear export of p57kip2 was correlated with promoted myelin expression, higher morphological phenotypes, and enhanced myelination in vitro. In contrast, nuclear accumulation of p57kip2 resulted in blocked oligodendroglial differentiation. Experimental evidence suggests that the inhibitory role of p57kip2 depends on specific interactions with binding proteins such as LIMK-1, CDK2, Mash1, and Hes5 either by controlling their site of action or their activity. Because functional restoration in demyelinating diseases critically depends on the successful generation of oligodendroglial cells, a therapeutic need that is currently unmet, the regulatory mechanism described here might be of particular interest for identifying suitable drug targets and devising novel therapeutic approaches.