Miracle-dz/UniFAR-FTUs huggingface dataset:
Hazardous Anticancer Drugs in Health Care

Abstract: Exposure of healthcare workers to anticancer drugs became problematic in the 1970s. Shortly thereafter, studies began documenting exposure of healthcare workers to these drugs. Investigations employing biological markers, such as urine mutagenicity, chromosomal aberrations, sister chromatid exchanges, and micronuclei, demonstrated associations between occupational exposures and elevated marker levels. Other analytical methods emerged to monitor workplaces where drugs were handled. These contemporary studies uncovered widespread contamination of drugs on work surfaces, trace amounts in air samples, and their presence in the urine of workers. Vials containing these drugs are often contaminated with the drug when they are shipped. Most workplace surfaces are contaminated with the drugs being prepared and used in that area. Other anticancer/hazardous drugs would most likely be used in these areas. The interior surfaces of biological safety cabinets and isolators, floors, countertops, carts, storage bins, waste containers, treatment areas, tabletops, chairs, linen, and other items are all potential sources of exposure to anticancer drugs. Patient body fluids contain the drugs and/or metabolites, often more biologically active than the parent compounds. An exposure assessment of areas where anticancer/hazardous drugs are handled must consider every potential source and route of exposure. Data from surface contamination and inhalation studies suggest that dermal exposure is the primary route of exposure. Assessment of exposure is the first step in providing a safe work environment for these workers. However, because of the many drugs to which they are exposed, any assessment can only be an estimation of the overall exposure.
Symbolic analysis of large analog circuits with determinant decision diagrams

Symbolic analog-circuit analysis has many applications, and is especially useful for analog synthesis and testability analysis. We present a new approach to exact and canonical symbolic analysis by exploiting the sparsity and sharing of product terms. It consists of representing the symbolic determinant of a circuit matrix by a graph-called determinant decision diagram (DDD)-and performing symbolic analysis by graph manipulations. We showed that DDD construction and DDD-based symbolic analysis can be performed in time complexity proportional to the number of DDD vertices. We described a vertex ordering heuristic, and showed that the number of DDD vertices can be quite small-usually orders-of-magnitude less than the number of product terms. The algorithm has been implemented. An order-of-magnitude improvement in both CPU time and memory usage over existing symbolic analyzers ISAAC and Maple-V has been observed for large analog circuits.
Spanish-English Bilingual Students' Use of Cognates in English Reading

A study was conducted to determine how Hispanic bilingual students' knowledge of Spanish vocabulary and ability to identify Spanish-English cognates relate to their comprehension of English expository text. Subjects, 74 upper elementary Hispanic students able to read in both Spanish and English, were tested for Spanish and English vocabulary knowledge, and after reading each of four expository texts containing English words with Spanish cognates (e.g., English transform and Spanish transformar) were given a multiple-choice test on their understanding of key concepts from these texts. After a brief explanation of the concept cognate, they were asked to identify the words in these texts that had Spanish cognates. Performance on the multiple-choice test was found to be related to students' ability to recognize cognate relationships. The relationship between Spanish vocabulary knowledge and English reading comprehension also appeared to depend on students' ability to recognize cognates.
Asymmetries of Manual Motor Response in Relation to Age, Sex, Handedness, and Occupational Activities

Questions about left- and right-hand asymmetries require the analysis of preference and manual skill with respect to handedness. Hand preference and hand skill were examined in relation to sex, age, and occupational activities. 512 adults from manual, mixed, and intellectual activities and 253 children were tested for their manual preferences and performance. Analysis of variance followed by Scheffé post hoc tests, for right-handed adults, indicated significant effects for occupational activity and sex in dexterity and strength. Manual workers, under technological pressure, seemed more consistent in their manual preferences than their peers. For left-handed persons there were no significant effects. Dexterity and strength were also related to sex and age, suggesting different cultural opportunities for both sexes in relation to motor activities.
Ghrelin as a Novel Therapy for Radiation Combined Injury

The threat of nuclear terrorism has led to growing worldwide concern about exposure to radiation. Acute radiation syndrome, or radiation sickness, develops after whole-body or a partial-body irradiation with a high dose of radiation. In the terrorist radiation exposure scenario, however, radiation victims likely suffer from additional injuries such as trauma, burns, wounds or sepsis. Thus, high-dose radiation injuries and appropriate therapeutic interventions must be studied. Despite advances in our understanding of the pathophysiology of radiation injury, very little information is available on the therapeutic approaches to radiation combined injury. In this review, we describe briefly the pathological consequences of ionizing radiation and provide an overview of the animal models of radiation combined injury. We highlight the combined radiation and sepsis model we recently established and suggest the use of ghrelin, a novel gastrointestinal hormone, as a potential therapy for radiation combined injury.
Monitoring the pathways and outcomes of people from disadvantaged backgrounds and graduate groups

The development of a strong and vibrant knowledge economy is linked directly to successful learning outcomes among university graduates. Building evidence‐based insights on graduate outcomes plays a particularly important role in shaping planning and practice. To this end, this paper analyses some key findings from the Graduate Pathways Survey, the first national study in Australia of bachelor degree graduates' outcomes five years after course completion. It focuses on the outcomes of graduates from disadvantaged groups, people of particular significance in an expanding and increasingly important higher education system. After advancing the rational for this analysis, the paper sketches the overall research approach. The paper continues with an analysis of education and employment outcomes for the target groups, and concludes by summarising implications for building further research insights.
) in silico Whole Genome Sequencer & Analyzer (iWGS): a computational pipeline to guide the design and analysis of de novo genome sequencing studies

The availability of genomes across the tree of life is highly biased toward vertebrates, pathogens, human disease models, and organisms with small and streamlined genomes. Recent progress in genomics has enabled the de novo decoding of the genome of virtually any organism, greatly expanding its potential for understanding the biology and evolution of the full spectrum of biodiversity. The increasing diversity of sequencing technologies, assays, and de novo assembly algorithms have augmented the complexity of de novo genome sequencing projects in non-model organisms. To reduce the costs and challenges in de novo genome sequencing projects and streamline their experimental design and analysis, we developed iWGS ( in silico Whole Genome Sequencer and Analyzer), an automated pipeline for guiding the choice of appropriate sequencing strategy and assembly protocols. iWGS seamlessly integrates the four key steps of a de novo genome sequencing project: data generation (through simulation), data quality control, de novo assembly, and assembly evaluation and validation. The last three steps can also be applied to the analysis of real data. iWGS is designed to enable the user to have great flexibility in testing the range of experimental designs available for genome sequencing projects, and supports all major sequencing technologies and popular assembly tools. Three case studies illustrate how iWGS can guide the design of de novo genome sequencing projects and evaluate the performance of a wide variety of user-specified sequencing strategies and assembly protocols on genomes of differing architectures. iWGS, along with a detailed documentation, is freely available at http://as.vanderbilt. edu/rokaslab/tools.html.
Combining Acoustic Echo Cancellation and Suppression

The acoustic echo problem arises whenever there is acoustic coupling between a loudspeaker and a microphone, such as in a teleconference system. This problem is traditionally solved by using an acoustic echo canceler (AEC), which models the echo path with adaptive filters. Long adaptive filters are necessary for satisfactory echo cancellation, which makes AEC highly computationally complex. Recently, a low-complexity echo suppression scheme was presented, the perceptual acoustic echo suppressor (PAES). Spectral modification is used to suppress the echoes, and the complexity is reduced by incorporating perceptual theories. However, under ideal conditions AEC performs better than PAES. This thesis considers a hybrid system, which combines AEC and PAES. AEC is used to cancel low-frequency echo components, while PAES suppresses high-frequency echo components. The hybrid system is simulated and assessed, both through subjective listening tests and objective evaluations. The hybrid scheme is shown to have virtually the same perceived quality as a full-band AEC, while having a significantly lower complexity and a higher degree of robustness.
Picture naming deficits in developmental dyslexia in German

Recent research with English developmental dyslexics comparing the picture naming performance of these children to the picture naming performance of non-dyslexic (‘garden variety’) poor readers, reading age matched controls and chronological age matched controls has suggested that a selective difficulty in retrieving the phonological codes of known names on demand underlies the picture naming deficit found in developmental dyslexia (Swan & Goswami, Picture naming deficits in developmental dyslexia: the phonological representations hypothesis, Brain and Language, 56 (1997), 334–353). If the underlying causal factors in dyslexia are independent of the orthography that the child is learning to read, then a difficulty in retrieving the phonological codes of known names on demand should also be found in developmental dyslexics who are learning to read other languages. We therefore set out to replicate Swan and Goswami’s study with a group of German developmental dyslexics. We were interested to see whether a phonological deficit is characteristic of dyslexia in all orthographies, even those, such as German, in which high orthographic transparency means that dyslexic children read with considerable accuracy.
Using Self-Definition to Predict the Influence of Procedural Justice on Organizational-, Interpersonal-, and Job/Task-Oriented Citizenship Behavior

An integrative self-definition model is proposed to improve our understanding of how procedural justice affects different outcome modalities in organizational behavior. Specifically, it is examined whether the strength of different levels of self-definition (collective, relational, and individual) each uniquely interact with procedural justice to predict organizational, interpersonal, and job/task-oriented citizenship behaviors, respectively. Results from experimental and (both single and multisource) field data consistently revealed stronger procedural justice effects (1) on organizational-oriented citizenship behavior among those who define themselves strongly in terms of organizational characteristics, (2) on interpersonal-oriented citizenship behavior among those who define themselves strongly in terms of their interpersonal relationships, and (3) on job/task-oriented citizenship behavior among those who define themselves weakly in terms of their distinctiveness or uniqueness. We discuss the relevance of these results with respect to how employees can be motivated most effectively in organizational settings.
Age-Group Differences in Set-Switching and Set-Maintenance on the Wisconsin Card Sorting Task

This study examined developmental change in set-switching and set-maintenance on the Wisconsin Card Sorting Task (WCST), and sought to determine how executive function (EF) components (i.e., Working Memory, Shifting and Inhibition) may contribute to the observed changes on WCST performance. To this end, performance in four age groups (7-year-olds, 11-year-olds, 15-year-olds, and 21-year-olds) was measured on the WCST, and on three EF tasks assumed to tap Working Memory, Shifting, and Inhibition. The results showed that adult levels of performance were reached in 11-year-olds for set-switching, and in 15-year-olds for set-maintenance. A subsequent principal component analysis revealed that set-switching and set-maintenance loaded on two factors for 7-year-olds, but a single factor in the other age groups. Finally, regression analyses yielded a complex pattern of results concerning the prediction of set-switching and set-maintenance by the performance on tasks used to assess the EF components. The results were interpreted to suggest distinct developmental trends in set-switching and set-maintenance abilities required by the WCST.
[Hearing loss and human immunodeficiency virus infection. Study of 30 patients].

OBJECTIVE To asses hearing loss in patients infected with the human immunodeficiency virus (HIV) and its relationship with clinical stage (fulfillment of diagnostic criteria for human acquired immunodeficiency syndrome/AIDS) and degree of lymphocyte depletion (number of CD4+ lymphocytes). METHODS Assessment of thirty consecutive HIV-infected patients regarding the presence of subjective hearing loss, pure-tone audiometry, brain stem auditory evoked potentials (BAEP); and number of CD4+ lymphocytes and treatment with antiretroviral drugs. RESULTS Forty percent of patients reported hearing loss; 33% had an abnormal audiometry and BAEPs were abnormal in 56% of patients. The most common findings included high-frequency sensorineural loss and an increase in the wave III latency and interaural I-V difference. Subjective hearing loss and an abnormal audiometry were both related to the administration of antiretroviral drugs, whereas abnormal BAEPs were related to AIDS and low CD4+ lymphocyte counts. CONCLUSIONS In HIV infected patients, an abnormal BAEP is the most common audiologic disorder, particularly in the advanced stages of the disease.
Rotational Remodeling of Malrotated Femoral Fractures: A Model in the Rabbit

It is estimated that 20–40% of femoral fractures in children heal in malrotation, yet few patients later complain. To determine if malrotation corrects spontaneously, midshaft osteotomies were made in femurs of 16 rabbits aged 8 weeks and the distal fragments were internally rotated 45°, where they were held with external fixators. The animals were killed between week 0 and week 17. Version of the femoral necks was determined by computed tomography scan (CT). The version altered rapidly toward normal from weeks 0 to 4 and then remained stable, with an average rotational remodeling of 55%.
Trust, Control, and Risk in Strategic Alliances: An Integrated Framework

Trust and control are inextricably interlinked with risk in strategic alliances. Hence, to understand how partner firms can effectively reduce and manage this risk, we need to examine the inter-relationships between trust, control, and risk. In this article, we propose a comprehensive and integrated framework of the three constructs in the context of strategic alliances, contending that trust and control are the two principal antecedents of risk. First, we suggest that the three constructs are each comprised of certain key dimensions. Risk can be considered separately as relational risk and performance risk. The two dimensions of trust are identified as goodwill trust and competence trust, and control is differentiated in terms of the three modes of behaviour control, output control, and social control. Second, we discuss systematically the various linkages between the different types of trust, control, and risk in alliances. Third, we suggest several risk reduction approaches — minimizing relational risk through goodwill trust, behaviour control, and social control, while minimizing performance risk through competence trust, output control, and social control. Fourth, we discuss a number of trust-building techniques and control mechanisms to reduce risk in different types of strategic alliances. Finally, we develop propositions for empirical testing of the integrated framework and offer brief comments on future research directions and managerial implications
Inflammatory Mechanisms Associated with Skeletal Muscle Sequelae after Stroke: Role of Physical Exercise

Inflammatory markers are increased systematically and locally (e.g., skeletal muscle) in stroke patients. Besides being associated with cardiovascular risk factors, proinflammatory cytokines seem to play a key role in muscle atrophy by regulating the pathways involved in this condition. As such, they may cause severe decrease in muscle strength and power, as well as impairment in cardiorespiratory fitness. On the other hand, physical exercise (PE) has been widely suggested as a powerful tool for treating stroke patients, since PE is able to regenerate, even if partially, physical and cognitive functions. However, the mechanisms underlying the beneficial effects of physical exercise in poststroke patients remain poorly understood. Thus, in this study we analyze the candidate mechanisms associated with muscle atrophy in stroke patients, as well as the modulatory effect of inflammation in this condition. Later, we suggest the two strongest anti-inflammatory candidate mechanisms, myokines and the cholinergic anti-inflammatory pathway, which may be activated by physical exercise and may contribute to a decrease in proinflammatory markers of poststroke patients.
Randomised trial of a parent‐mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years

Background There has been increasing interest in the potential for pre‐emptive interventions in the prodrome of autism, but little investigation as to their effect. Methods A two‐site, two‐arm assessor‐blinded randomised controlled trial (RCT) of a 12‐session parent‐mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings‐Video Interaction for Promoting Positive Parenting), against no intervention. Fifty‐four infants (28 intervention, 26 nonintervention) at familial risk of autism but not otherwise selected for developmental atypicality were assessed at 9‐month baseline, 15‐month treatment endpoint, and 27‐ and 39‐month follow‐up. Primary outcome: severity of autism prodromal symptoms, blind‐rated on Autism Observation Schedule for Infants or Autism Diagnostic Observation Schedule 2nd Edition across the four assessment points. Secondary outcomes: blind‐rated parent–child interaction and child language; nonblind parent‐rated communication and socialisation. Prespecified intention‐to‐treat analysis combined estimates from repeated measures within correlated regressions to estimate the overall effect of the infancy intervention over time. Results Effect estimates in favour of intervention on autism prodromal symptoms, maximal at 27 months, had confidence intervals (CIs) at each separate time point including the null, but showed a significant overall effect over the course of the intervention and follow‐up period (effect size [ES] = 0.32; 95% CI 0.04, 0.60; p = .026). Effects on proximal intervention targets of parent nondirectiveness/synchrony (ES = 0.33; CI 0.04, 0.63; p = .013) and child attentiveness/communication initiation (ES = 0.36; 95% CI 0.04, 0.68; p = .015) showed similar results. There was no effect on categorical diagnostic outcome or formal language measures. Conclusions Follow‐up to 3 years of the first RCT of a very early social communication intervention for infants at familial risk of developing autism has shown a treatment effect, extending 24 months after intervention end, to reduce the overall severity of autism prodromal symptoms and enhance parent–child dyadic social communication over this period. We highlight the value of extended follow‐up and repeat assessment for early intervention trials.
Reading Ability and Assigned Materials: Accommodation for the Slow but Not the Accelerated

educational literature of the past several decades (1). There is little empirical evidence, however, on what has been done to adapt typical classroom assignments to the needs of the individual child. Because reading is central in the elementary-school program and because reading materials are widely available at all levels, reading is a particularly appropriate area for an investigation of the accommodation of the curriculum to individual differences.
Alcohol intake modifies leptin, adiponectin and resistin serum levels and their mRNA expressions in adipose tissue of rats.

OBJECTIVE Alcohol intake is known to interfere with endocrine system functions thus inducing hormonal and metabolic imbalance. The aim was to investigate the impact of chronic intake of mild alcohol concentration on serum leptin, adiponectin and resistin and their gene expression in epididymal adipose tissue (EAT) of rats. METHODS The 28 days study was based on 3 experimental groups of adult male Wistar rats: 1/ ad libitum intake of 6 % ethanol solution and pelleted diet (A), 2/ pair fed animals (PF) fed pelleted diet in the same caloric amount as A rats on previous day (alcohol+diet), 3/ control rats (C) with unrestricted intake of water and pelleted diet. RT-PCR method was used for determination of adipokines gene expression in epididymal adipose tissue, serum levels were measured by ELISA kits. RESULTS The animals of A group were characterized by reduced food and energy intake (-10 % vs C), lower body mass gain, reduced epididymal fat mass with smaller adipocytes. Alcohol consumption significantly increased glycemia, serum insulin was not affected. The raise of NEFA in A and PF rats gives the evidence of intensified lipolysis due to the deficiency of energy intake. Alcohol consumption significantly increased serum leptin and resistin, elevated adiponectin was present in A and PF rats. In parallel with increased serum levels the expression of adiponectin gene in epididymal adipose tissue was elevated in the same A and PF rats. Leptin and resistin mRNA levels were similar as in C regardless of alcohol intake or pair-fed feeding. Increased leptin and resistin levels positively correlated with glycemia and negatively with the size of adipocytes. Elevated serum leptin and resistin together with high adiponectin after chronic moderate alcohol intake could contribute to alteration of energy metabolism either individually or in reciprocal coordination. CONCLUSIONS 28 days consumption of 6 % ethanol solution changed the nutritional status of rats and induced significant elevation of serum leptin and resistin, while elevated gene expression in epididymal adipose tissue was proved for adiponectin only. Elevated serum adipokines could contribute to increased glycemia and altered glucose homeostasis.