Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term outcomes after adjuvant treatment of sequential versus combination docetaxel with doxorubicin and cyclophosphamide in node-positive breast cancer: BCIRG-005 randomized trial.

BACKGROUND The optimal regimen for adjuvant breast cancer chemotherapy is undefined. We compared sequential to concurrent combination of doxorubicin and cyclophosphamide with docetaxel chemotherapy in women with node-positive non-metastatic breast cancer. We report the final, 10-year analysis of disease-free survival (DFS), overall survival (OS), and long-term safety. PATIENTS AND METHODS A total of 3298 women with HER2 nonamplified breast cancer were randomized to doxorubicin and cyclophosphamide every 3 weeks for four cycles followed by docetaxel (AC → T) every 3 weeks for four cycles or docetaxel, doxorubicin, and cyclophosphamide (TAC) every 3 weeks for six cycles. The patients received standard radiotherapy and endocrine therapy and were followed up for 10 years with annual clinical evaluation and mammography. RESULTS The 10-year DFS rates were 66.5% in the AC → T arm and 66.3% in the TAC arm (P = 0.749). OS was 79.9% in the AC → T arm and 78.9% in the TAC arm (P = 0.506). TAC was associated with higher rates of febrile neutropenia, although G-CSF primary prophylaxis greatly reduced this risk. AC → T was associated with a higher rate of myalgia, hand-foot syndrome, fluid retention, and sensory neuropathy. CONCLUSION This 10-year analysis of the BCIRG-005 trial confirmed that the efficacy of TAC was not superior to AC → T in women with node-positive early breast cancer. The toxicity profiles differ between arms and were consistent with previous reports. The TAC regimen with G-CSF support provides shorter adjuvant treatment duration with less toxicity. TRIAL REGISTRATION ClinicalTrials.gov Identifier NCT00312208.
Employee participation in UK Sharesave schemes: a firm-level analysis

Employee records and interviews are used to ascertain the reasons why employees do and do not participate in Sharesave schemes in three companies in the UK retail sector. A model is used to compare the reasons for participation and non-participation given in the literature to the findings of this research. This paper's interpretivist approach brings out the direct views of employees placing equal emphasis on non-participants' views as well as those of participants. The benefits of such schemes claimed by Government and employers are not found to influence participation. Employees saw such schemes as a simple way to save. Non-participation was predominantly due to the employee not expecting to remain with the company.
Mandatory Audit Firm Turnover, Financial Reporting Quality, and Client Bargaining Power: The Case of Arthur Andersen

This paper examines the effect of mandatory auditor change on audit quality in the unique environment created by the failure of Arthur Andersen (AA). The failure of AA forced a significant number of companies (ex‐AA clients) to change auditors and also helped increase the overall skepticism exhibited on external audits. The demise of AA does not truly replicate a mandatory rotation regime, but it does provide a rich setting to examine one aspect of such a regime—the effect that a forced auditor change has on the level of audit quality. Furthermore, because ex‐AA clients were forced to change auditors on a one‐time basis and will not necessarily have to change auditors in the future, client bargaining power is likely to influence auditor behavior and is considered in this study's empirical analyses. This study provides evidence that, for smaller companies, the level of audit quality improved for companies forced to switch from AA, and that the negative relation between short auditor tenure and audit qualit.
Adapting management accounting knowledge needs to functional and economic change

Abstract Changes in the function of the management accountant and in the economic environment, particularly the shift of economic activity away from manufacturing and the internationalisation of education, raise issues of the breadth and diversity of knowledge needs for management accounting. The impact of these issues is investigated using data on perceived topic importance from an international survey of over 1600 members of the Chartered Institute of Management Accountants. The substantial importance attached to a range of topics from outside the management accounting discipline itself, and to more strategic topics from within it, is consistent with a developing function for the practitioner associated with a broadening set of knowledge needs, since these topics add to rather than supplant many traditional core management accounting topics. Variation in the importance of topics among economic sectors tends to be specific to certain topics, such as costing, although the public sector has distinctive priorities. Diversity in knowledge needs is also apparent internationally, particularly in terms of those working in developing economies, who attach greater importance to many topics in finance and financial accounting than others do.
Tolerance to high‐internalizing δ opioid receptor agonist is critically mediated by arrestin 2

Opioid δ receptor agonists are potent antihyperalgesics in chronic pain models, but tolerance develops after prolonged use. Previous evidence indicates that distinct forms of tolerance occur depending on the internalization properties of δ receptor agonists. As arrestins are important in receptor internalization, we investigated the role of arrestin 2 (β‐arrestin 1) in mediating the development of tolerance induced by high‐ and low‐internalizing δ receptor agonists.
Psychological Factors and Conditioned Pain Modulation: A Meta-Analysis

Objective:Conditioned pain modulation (CPM) responses may be affected by psychological factors such as anxiety, depression, and pain catastrophizing; however, most studies on CPM do not address these relations as their primary outcome. The aim of this meta-analysis was to analyze the findings regarding the associations between CPM responses and psychological factors in both pain-free individuals and pain patients. Materials and Methods:After a comprehensive PubMed search, 37 articles were found to be suitable for inclusion. Analyses used DerSimonian and Laird’s random-effects model on Fisher’s z-transforms of correlations; potential publication bias was tested using funnel plots and Egger’s regression test for funnel plot asymmetry. Six meta-analyses were performed examining the correlations between anxiety, depression, and pain catastrophizing, and CPM responses in healthy individuals and pain patients. Results:No significant correlations between CPM responses and any of the examined psychological factors were found. However, a secondary analysis, comparing modality-specific CPM responses and psychological factors in healthy individuals, revealed the following: (1) pressure-based CPM responses were correlated with anxiety (grand mean correlation in original units r=−0.1087; 95% confidence limits, –0.1752 to −0.0411); (2) heat-based CPM was correlated with depression (r=0.2443; 95% confidence limits, 0.0150 to 0.4492); and (3) electrical-based CPM was correlated with pain catastrophizing levels (r=−0.1501; 95% confidence limits, −0.2403 to −0.0574). Discussion:Certain psychological factors seem to be associated with modality-specific CPM responses in healthy individuals. This potentially supports the notion that CPM paradigms evoked by different stimulation modalities represent different underlying mechanisms.
Fiscal Devaluations in EMU

We use a small open economy general equilibrium model to analyse the effects of a fiscal devaluation in an EMU country. The model has been calibrated for the Spanish economy, which is a good example of the advantages of a change in the tax mix given that its tax system shows a positive bias in the ratio of social security contributions over consumption taxes. The preliminary empirical evidence for European countries shows that this bias was negatively correlated with the current account balance in the expansionary years leading up to the 2009 crisis, a period when many EMU members accumulated large external imbalances. Our simulation results point to significant positive effects of a fiscal devaluation on GDP and employment similar to the ones that could be obtained with an ex-change rate devaluation. However, although the effects in terms of GDP and employment are similar, the composition effects of fiscal and nominal devaluations are not alike. In both cases, there is an improvement in net exports, but the effects on domestic and external demand are quite different.
PoseHD: Boosting Human Detectors Using Human Pose Information

As most recently proposed methods for human detection have achieved a sufficiently high recall rate within a reasonable number of proposals, in this paper, we mainly focus on how to improve the precision rate of human detectors. In order to address the two main challenges in precision improvement, i.e., i) hard background instances and ii) redundant partial proposals, we propose the novel PoseHD framework, a top-down pose-based approach on the basis of an arbitrary state-of-the-art human detector. In our proposed PoseHD framework, we first make use of human pose estimation (in a batch manner) and present pose heatmap classification (by a convolutional neural network) to eliminate hard negatives by extracting the more detailed structural information; then, we utilize pose-based proposal clustering and reranking modules, filtering redundant partial proposals by comprehensively considering both holistic and part information. The experimental results on multiple pedestrian benchmark datasets validate that our proposed PoseHD framework can generally improve the overall performance of recent state-of-the-art human detectors (by 2-4% in both mAP and MR metrics). Moreover, our PoseHD framework can be easily extended to object detection with large-scale object part annotations. Finally, in this paper, we present extensive ablative analysis to compare our approach with these traditional bottom-up pose-based models and highlight the importance of our framework design decisions.
Determination of α in the Cadmium Lined Irradiation Channel of the NIRR-1 for Use in ko-ENAA

The epithermal neutron shape factor (α) was determined in the permanent cadmium lined irradiation channel installed in the large outer irradiation site of the Nigeria Research Reactor-1 (NIRR- 1) by the cadmium covered multimonitor method using the monitors Al-0.1% Au, Zr and Zn thin foils and Mo thin wire and was found to be -0.137 ± 0.018. The high negative value of α indicates a hardened epithermal neutron spectrum in the cadmium lined irradiation channel. The α value obtained was used in the single comparator method of ENAA (ko-ENAA) for the determination of the concentrations of elements in the standard reference material NIST 1515 Apple leaves using Al-0.1% Au thin foil as the single comparator. The concentrations of the elements Sm and Br were determined in the NIST 1515 Apple leaves because of their high Qo values and are in good agreement with the certified values.
Synthesis and Evaluation of a Series of 99mTc(CO)3+ Lisinopril Complexes for In Vivo Imaging of Angiotensin-Converting Enzyme Expression

In animal models of cardiac disease and in human congestive heart failure, expression of angiotensin-converting enzyme (ACE) is upregulated in the failing heart and has been associated with disease progression leading to cardiac failure and fibrosis. To develop probes for imaging ACE expression, a series of di(2-pyridylmethyl)amine (D) chelates capable of binding M(CO)3+ (M = technetium, rhenium) was conjugated to lisinopril by acylation of the ε-amine of the lysine residue with a series of di(2-pyridylmethylamino)alkanoic acids where the distance of the chelator from the lisinopril core was investigated by varying the number of methylene spacer groups to produce di(2-pyridylmethyl)amine(Cx)lisinopril analogs: D(C4)lisinopril, D(C5)lisinopril, and D(C8)lisinopril. The inhibitory activity of each rhenium complex was evaluated in vitro against purified rabbit lung ACE and was shown to vary directly with the length of the methylene spacer: Re[D(C8)lisinopril], inhibitory concentration of 50% (IC50) = 3 nM; Re[D(C5)lisinopril], IC50 = 144 nM; and Re[D(C4)lisinopril], IC50 = 1,146 nM, as compared with lisinopril, IC50 = 4 nM. The in vivo specificity for ACE was determined by examining the biodistribution of the 99mTc-[D(C8)lisinopril] analog in rats with and without pretreatment with unlabeled lisinopril. Uptake in the lungs, a tissue that constitutively expresses ACE, was 15.2 percentage injected dose per gram at 10 min after injection and was dramatically reduced by pretreatment with lisinopril, supporting ACE-mediated binding in vivo. Planar anterior imaging analysis of 99mTc-[D(C8)lisinopril] corroborated these data. Thus, high-affinity 99mTc-labeled ACE inhibitor has been designed with potency similar to that of lisinopril and has been demonstrated to specifically localize to tissues that express ACE in vivo. This agent may be useful in monitoring ACE as a function of disease progression in relevant diseases such as heart failure.
Glucose stimulates intestinal epithelial crypt proliferation by modulating cellular energy metabolism

The intestinal epithelium plays an essential role in nutrient absorption, hormone release, and barrier function. Maintenance of the epithelium is driven by continuous cell renewal by stem cells located in the intestinal crypts. The amount and type of diet influence this process and result in changes in the size and cellular make‐up of the tissue. The mechanism underlying the nutrient‐driven changes in proliferation is not known, but may involve a shift in intracellular metabolism that allows for more nutrients to be used to manufacture new cells. We hypothesized that nutrient availability drives changes in cellular energy metabolism of small intestinal epithelial crypts that could contribute to increases in crypt proliferation. We utilized primary small intestinal epithelial crypts from C57BL/6J mice to study (1) the effect of glucose on crypt proliferation and (2) the effect of glucose on crypt metabolism using an extracellular flux analyzer for real‐time metabolic measurements. We found that glucose increased both crypt proliferation and glycolysis, and the glycolytic pathway inhibitor 2‐deoxy‐d‐glucose (2‐DG) attenuated glucose‐induced crypt proliferation. Glucose did not enhance glucose oxidation, but did increase the maximum mitochondrial respiratory capacity, which may contribute to glucose‐induced increases in proliferation. Glucose activated Akt/HIF‐1α signaling pathway, which might be at least in part responsible for glucose‐induced glycolysis and cell proliferation. These results suggest that high glucose availability induces an increase in crypt proliferation by inducing an increase in glycolysis with no change in glucose oxidation.
Supporting the development of biobanks in low and medium income countries

Biobanks are an organized collection of biological material and associated data. They are a fundamental resource for life science research and contribute to the development of pharmaceutical drugs, diagnostic markers and to a deeper understanding of the genetics that regulate the development of all life on earth. Biobanks are well established in High Income Countries (HIC) and are rapidly emerging in Low and Middle Income Countries (LMIC). Surveys among biobanks operating in a LMIC setting indicate that limited resources and short term funding tied to specific projects threaten the sustainability of the biobanks. Fit-for-purpose biobanks targeting major societal challenges such as HIV and Malaria provide an excellent basis for integrating biobanks with the available research communities in LMIC regions. But to become sustainable for the future it is important that biobanks become an integrated part of local research communities. To achieve this, the cost of operating biobanks must be lowered, templates must be developed to support local ethics committees and researchers must be given the opportunity to build experience in successfully operating biobank based research projects. The B3Africa consortium is based on these conclusions and set up to support biobank based research by creating a cost efficient Laboratory Information Management System (LIMS) for developing biobanks and also contribute to the training and capacity building in the local research community. The technical platform called the eB3Kit is open source and consists of a LIMS and a bioinformatics module based on the eBiokit that allow researchers to take control over the analysis of their own data. Along with the technical platform the consortium will also contribute training and support for the associated infrastructures necessary to regulate the ethical and legal implications of biobank based research.
Genetic Relatedness and Quinolone Resistance of Campylobacter jejuni Strains Isolated in 2002 in Hong Kong

ABSTRACT Pulsed-field gel electrophoresis fingerprints of 98 Campylobacter jejuni isolates from patients (85) and chicken carcasses (13) in Hong Kong in 2002 demonstrated high genetic diversity. The prevalence of quinolone resistance among the isolates was 85.9%, and replacement of the threonine-86 residue in the gyrase subunit A was the major resistance mechanism.
Residential Satisfaction, Moving Intention and Moving Behaviours: A Study of Redeveloped Neighbourhoods in Inner-City Beijing

This paper studies residential satisfaction among original residents in the redeveloped inner-city neighbourhoods of Beijing. It is based on a questionnaire survey that was conducted in four neighbourhoods redeveloped at different time periods in the past 15 years. The survey data suggest an overall low level of satisfaction across all four neighbourhoods. Only the unit size and length of stay significantly relate to residential satisfaction. The survey shows that low residential satisfaction does not lead to frequent moving behaviours despite high moving intentions. These findings contradict hypotheses in the Western literature about lower residential satisfaction associated with higher mobility. In Western studies, residential satisfaction determines housing adjustment and mobility behaviours, which form the basis for public intervention. The central assumption is that residents' mobility will be relatively unhindered by factors other than personal financial ability. By differentiating between voluntary and involuntary relocation behaviour, this paper attempts to understand the interrelationship between residential satisfaction, moving intention and moving behaviour within the context of China's political economy. Residents in this study showed a lack of ability to adjust their changing housing needs although they had strong desires to do so. China's housing reform provides a valuable opportunity to examine the impacts of constraints and choices on residential satisfaction, and sheds light on decision processes of housing market development.
Credit Programmes for the Poor and Seasonality in Rural Bangladesh

This article examines the effect of group-based credit used to finance self-employment by landless households in Bangladesh on the seasonal pattern of household consumption and male and female labour supply. This credit can help smooth seasonal consumption by financing new productive activities whose income flows and time demands do not seasonally covary with the income generated by existing agricultural activities. The results, based upon 1991/92 survey data, strongly suggest that an important motivation for credit programme participation is the need to smooth the seasonal pattern of consumption and male labour supply. It is only the extent of lean season consumption poverty that selects household into these programmes. In addition, the largest female and male effects of credit on household consumption are during the lean season.
Barriers to Municipal Climate Adaptation: Examples From Coastal Massachusetts’ Smaller Cities and Towns

Problem, research strategy, and findings: Many global cities are making good progress on climate adaptation. There is less information, however, on climate adaptation among smaller cities and towns: Are their approaches similar when undertaking adaptation? Do the barriers they face mirror those of large cities? In this study, we undertake fine-grained empirical research on the perceptions of 18 municipal planners in 14 coastal cities and towns in Massachusetts; our findings are thus limited to planners’ perceptions of efforts and barriers in one region of the United States. These communities are very early in the uptake of climate adaptation policies and use a range of approaches when they do begin adaptation, including planning, mainstreaming, or addressing current hazards. The planners interviewed reported that barriers to adaptation actions tend to be interconnected; for example, the strength of private property interests often limits local political leadership on the issue. Without such leadership, it is difficult for planners to allocate time and/or money to adaptation activities. It is also challenging to gain support from local residents for climate adaptation action, while a lack of accepted technical data complicates efforts. Takeaway for practice: In coastal Massachusetts, and perhaps elsewhere, local residents, planners, and their municipal bodies, as well as the states, must act in multiple ways to encourage the development of meaningful climate adaptation action in smaller cities and towns.
A conditional full frontier approach for investigating the Averch-Johnson effect

This paper applies a probabilistic approach in order to develop conditional and unconditional Data Envelopment Analysis (DEA) models for the measurement of sectors’ input oriented technical and scale efficiency levels for a sample of 23 Greek manufacturing sectors. In order to capture the Averch and Johnson effect (A-J effect), we measure sectors’ efficiency levels conditioned on the number of companies competing within the sectors. Particularly, various DEA models have been applied alongside with bootstrap techniques in order to determine the effect of competition conditions on sectors’ inefficiency levels. Additionally, this study illustrates how the recent developments in efficiency analysis and statistical inference can be applied when evaluating the effect of regulations in an industry. The results reveal that sectors with fewer numbers of companies appear to have greater scale and technical inefficiencies due to the existence of the A-J effect.
Gender differences in mental rotation strategy depend on degree of autistic traits

Participants with low, medium, and high autistic traits completed a mental rotation task while their eye movements were recorded. Men were more accurate than women (F(1, 102) = 4.36, P = 0.04, η2p = 0.04), but there were no group differences in reaction time. In terms of eye movements, all participants tended to rely on top corners of cube figures for most angles of rotation, and bottom corners of cube figures for 0 and 90 degree rotations (duration: F(8, 816) = 21.70, P < 0.001, η2p = 0.18; count: F(8, 816) = 24.42, P < 0.001, η2p = 0.19) suggesting a shift in strategy with rotation angle. Eye movements to corners of cube figures also varied by autistic traits group and gender (duration: F(4, 204) = 2.44, P = 0.05, η2p = 0.05; count: F(4, 204) = 2.47, P = 0.05, η2p = 0.05). Participants with low and medium autistic traits tended to rely more often on the top corners, whereas women with high autistic traits relied on both the top and bottom corners and men with high autistic traits relied on all corners equally. These results suggest mental rotation strategies may vary by both gender and autistic traits. Autism Res 2018, 11: 1024–1037. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.