Miracle-dz/UniFAR-FTUs huggingface dataset:
Perceived Treatment Needs Among Women With Co-occurring Substance Use Disorders and PTSD

ABSTRACT Objective: Perception of need is a key factor that influences decisions to seek help and complete treatment for substance use and mental health problems. In the current study, we examine patterns of perceived treatment needs among women with co-occurring substance use disorders and posttraumatic stress disorder (PTSD) and explore how these patterns are associated with demographics, psychosocial variables, and treatment-related factors. Methods: Secondary data analysis of the Women and Trauma Study from the National Institute on Drug Abuse's Clinical Trial Network was conducted. The sample included 353 women with co-occurring substance use disorders and PTSD (full or subthreshold) receiving outpatient substance abuse treatment. Latent class analysis was used to examine patterns of perceived treatment need and multinomial logistic regression was used to identify characteristics associated with these patterns. Results: The sample included women between the ages of 18 and 65 (mean = 39.2, SD = 9.3) and was 46% White, 34% African American, and 21% other races/ethnicities. A three-class model representing unique perceptions of treatment needs demonstrated the best fit (Bayesian information criterion = 2101.43; entropy = 0.76; average posterior probabilities ≤ 0.82). Class one reported elevated needs in multiple areas (38%), class two reported low needs (23%), and class three reported substance use and psychological needs (40%). Living with a substance abuser, depression symptoms, recent substance use, and treatment coercion were significantly associated with membership in class 2 (OR = .28, .84, .22, and 2.32, respectively). Other race, being married, depression symptoms, recent substance use, and criminal justice involvement were associated with membership in class 3 (OR = 2.32, 2.32, .94, .42, and 1.69, respectively). Number of treatment sessions attended was not significantly associated with class membership. Conclusions: Results provide insight into how women with co-occurring PTSD and substance use disorders view their treatment needs. While some women reported high levels of self-identified need in other areas (e.g., physical health, employment/financial support, and family or social relationships), others did not identify as having any problems (including substance use or psychological problems). Level of severity and temporal aspects of problems may be significant factors that influence women's perceived need for treatment. This clinical trial is registered at www.clinicaltrials. gov as trial #NCT00078156.
Preserving Theoretical Divergence in Management Research: Why the Explanatory Potential of Qualitative Research Should Be Harnessed Rather than Suppressed

Despite the evident rise in the number of qualitative studies that are published in leading journals, I argue that the rich tradition and hallmark of qualitative research is under pressure. In recent years qualitative papers are increasingly being fashioned in the image of quantitative research, so much so that papers adopt ‘factor-analytic’ styles of theorizing that have typically been the preserve of quantitative methods. This is a worrying trend as it leads to certain types of explanations dominating our field and at the expense of other viable forms of explanation. It also narrows the remit of qualitative research in general by channelling the theoretical contribution of qualitative studies in the direction of factor-analytic propositional or variance models. In this article, I discuss the differences between the distinct types of theoretical explanations that are associated with quantitative and qualitative methods, survey the trend towards a quantitative ‘restyling’ of qualitative research, and elaborate its negative implications for our body of knowledge and for the state of management and organization theory.
Cervical Pregnancy Analysis: A Review and Report of Five Cases

Five cases of cervical pregnancy are presented, with an incidence of 1:2400. Four of the cases, proved after hysterectomy and histopathologic confirmation, occurred in 1981. One was clinically most probable and was treated conservatively by curettage and packing. The distinction between proved and clinically probable cases of cervical pregnancy is defined. A review and analysis of the literature reveals an increasing incidence of cervical pregnancy. This may be due largely to increased numbers of induced abortions and sharp curetting. The maternal mortality rate has decreased from approximately 40 to 45% to zero in the past 30 years. Approximately 70% are treated necessarily by total hysterectomy. The remaining 30% are treated conservatively; however, ensuing pregnancies are rare in such women. Only three cases of pregnancy following probable cervical pregnancy have been reported. The last reported case was in 1953. (Obstet Gynecol 62:79, 1983)
Self-Interference Cancellation with RF Impairments Suppression for Full-Duplex Systems

In full-duplex systems, radio circuit's impairments is a significant factor that limits the cancellation of self-interference power. In this paper, we derive a closed-form expression of digital domain self- interference for a full-duplex orthogonal frequency division multiplexing (OFDM) system considering the RF impairments at the transmitter and the receiver. A digital-domain self-interference cancellation scheme (DSICS) that accounts for the power amplifier nonlinearity, IQ imbalance and phase noise effects at the transmitter and receiver is proposed. The DSICS can suppress the self-interference power effectively by compensating for the RF impairments associated with the self-interference signal.
Pengembangan Teori Keyness dalam Jumlah Konsumsi Muslim

The objective of this research is to implement the tought of John Maynard Keynes about consumer behavior and also its antithesis. This study takes muslim as a research subject because Islam as a religion own an institution in order to regulate every muslim in doing consume. This research was expected to find out whether the development of Keynes’s theory (thesis and antithesis) could be implemented in muslim community or not. The variables which used in the model are ammount of consumption (Y), income rate (X1), age (X2), religiosity (X3), and distinguishing community (faculty) as a dummy. Through multiple regression with dummy variable method, from 60 muslim respondents in two different community, was found that income rate (X1) and age (X2) was effected positively and significant to ammount of consumption (Y), religiosity (X3) was effected negatively and significant to ammount of consumption (Y), while dummy variable which is distinguishing community (faculty) was not effected significantly to ammount of consumption (Y). Therefore the dummy variable has dropped out from the research model. DOI: 10.15408/sjie.v4i2. 2304
Academic Affiliations of Social Work Journal Article Authors from 1999–2003

Abstract The academic affiliations of the authors of all articles published between 1999 and 2003 in six major social work journals were tabulated to produce a ranking of the colleges and universities whose faculty made the most substantive contributions to the social work literature. The results of this analysis are compared with findings of four identical, previously published studies, which cover the five-year periods of 197–1983, 1984–1988, 1989–1993, and 1994–1998. The limitations of this method of analysis are discussed, as are its merits.
Molecular Zn 2 Inhibits Mitochondrial Movement in Neurons by Phosphatidylinositol 3-Kinase Activation

Mitochondria have been identified as targets of the neurotoxic actions of zinc, possibly through decreased mitochondrial energy production and increased reactive oxygen species accumulation. It has been hypothesized that impairment of mitochondrial trafficking may be a mechanism of neuronal injury. Here, we report that elevated intraneuronal zinc impairs mitochondrial trafficking. At concentrations just sufficient to cause injury, zinc rapidly inhibited mitochondrial movement without altering morphology. Zinc chelation initially restored movement, but the actions of zinc became insensitive to chelator in 10 min. A search for downstream signaling events revealed that inhibitors of phosphatidylinositol (PI) 3-kinase prevented this zinc effect on movement. Moreover, transient inhibition of PI 3-kinase afforded neuroprotection against zinc-mediated toxicity. These data illustrate a novel mechanism that regulates mitochondrial trafficking in neurons and also suggest that mitochondrial trafficking may be closely coupled to neuronal viability.
Generation of Monocyte-Derived Insulin-Producing Cells from Non-Human Primates According to an Optimized Protocol for the Generation ofPCMO-Derived Insulin-Producing Cells

Objective: The vision of potential autologous cell therapy for the cure of diabetes encourages ongoing research. According to a previously published protocol for the generation of insulin-producing cells from human monocytes, we analyzed whether the addition of growth factors could increase insulin production. This protocol was then transferred to a non-human primate model by using either blood- or spleen-derived monocytes. Methods: Human monocytes were treated to dedifferentiate into programmable cells of monocytic origin (PCMO). In addition to the published protocol, PCMOs were then treated with either activin A, betacellulin, exendin 3 or 4. Cells were characterized by protein expression of insulin, Pdx-1, C-peptide and Glut-2. After identifying the optimal protocol, monocytes from baboon blood were isolated and the procedure was repeated. Spleen monocytes following splenectomy of a live baboon were differentiated and analyzed in the same manner and calculated in number and volume. Results: Insulin content of human cells was highest when cells were treated with activin A and their insulin content was 13 000 µU/1 million cells. Insulin-producing cells form primate monocytes could successfully be generated despite using human growth factors and serum. Expression of insulin, Pdx-1, C-peptide and Glut-2 was comparable to that of human neo-islets. Total insulin content of activin A-treated baboon monocytes was 16 000 µU/1 million cells. Conclusion: We were able to show that insulin-producing cells can be generated from baboon monocytes with human growth factors. The amount generated from one spleen could be enough to cure a baboon from experimentally induced diabetes in an autologous cell transplant setting.
Brachial plexopathy complicating Epstein-Barr virus infection in an adult

Acute Epstein-Barr virus (EBV) infection is associated with central and peripheral neurological complications such as meningitis, encephalitis, myelitis and radiculopathy in 0.5-7.5% of patients (1). The peripheral nervous system manifestations of acute EBV infection include mononeuropathy, mononeuritis multiplex, autonomic neuropathy, and polyradiculopathy (2). Brachial plexopathy in children and immunocompromised adults with acute EBV infection has been described, likely as a dysimmune neuropathy triggered by the EBV (3, 4). We present a case of brachial plexopathy complicating prior EBV infection in a healthy adult.
Glottal Spectral Separation for Speech Synthesis

This paper proposes an analysis method to separate the glottal source and vocal tract components of speech that is called Glottal Spectral Separation (GSS). This method can produce high-quality synthetic speech using an acoustic glottal source model. In the source-filter models commonly used in speech technology applications it is assumed the source is a spectrally flat excitation signal and the vocal tract filter can be represented by the spectral envelope of speech. Although this model can produce high-quality speech, it has limitations for voice transformation because it does not allow control over glottal parameters which are correlated with voice quality. The main problem with using a speech model that better represents the glottal source and the vocal tract filter is that current analysis methods for separating these components are not robust enough to produce the same speech quality as using a model based on the spectral envelope of speech. The proposed GSS method is an attempt to overcome this problem, and consists of the following three steps. Initially, the glottal source signal is estimated from the speech signal. Then, the speech spectrum is divided by the spectral envelope of the glottal source signal in order to remove the glottal source effects from the speech signal. Finally, the vocal tract transfer function is obtained by computing the spectral envelope of the resulting signal. In this work, the glottal source signal is represented using the Liljencrants-Fant model (LF-model). The experiments we present here show that the analysis-synthesis technique based on GSS can produce speech comparable to that of a high-quality vocoder that is based on the spectral envelope representation. However, it also permit control over voice qualities, namely to transform a modal voice into breathy and tense, by modifying the glottal parameters.
Comparison of exercise capacity in COPD and other etiologies of chronic respiratory failure requiring non-invasive mechanical ventilation at home: retrospective analysis of 1-year follow-up

Introduction The objective of this study was to compare the change in 6-minute walking distance (6MWD) in 1 year as an indicator of exercise capacity among patients undergoing home non-invasive mechanical ventilation (NIMV) due to chronic hypercapnic respiratory failure (CHRF) caused by different etiologies. Methods This retrospective cohort study was conducted in a tertiary pulmonary disease hospital in patients who had completed 1-year follow-up under home NIMV because of CHRF with different etiologies (ie, chronic obstructive pulmonary disease [COPD], obesity hypoventilation syndrome [OHS], kyphoscoliosis [KS], and diffuse parenchymal lung disease [DPLD]), between January 2011 and January 2012. The results of arterial blood gas (ABG) analyses and spirometry, and 6MWD measurements with 12-month interval were recorded from the patient files, in addition to demographics, comorbidities, and body mass indices. The groups were compared in terms of 6MWD via analysis of variance (ANOVA) and multiple linear regression (MLR) analysis (independent variables: analysis age, sex, baseline 6MWD, baseline forced expiratory volume in 1 second, and baseline partial carbon dioxide pressure, in reference to COPD group). Results A total of 105 patients with a mean age (± standard deviation) of 61±12 years of whom 37 had COPD, 34 had OHS, 20 had KS, and 14 had DPLD were included in statistical analysis. There were no significant differences between groups in the baseline and delta values of ABG and spirometry findings. Both univariate ANOVA and MLR showed that the OHS group had the lowest baseline 6MWD and the highest decrease in 1 year (linear regression coefficient −24.48; 95% CI −48.74 to −0.21, P=0.048); while the KS group had the best baseline values and the biggest improvement under home NIMV (linear regression coefficient 26.94; 95% CI −3.79 to 57.66, P=0.085). Conclusion The 6MWD measurements revealed improvement in exercise capacity test in CHRF patients receiving home NIMV treatment on long-term depends on etiological diagnoses.
Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein

Previous evidence indicates that a number of proteins are able to interact with cognate mRNAs. These autogenous associations represent important regulatory mechanisms that control gene expression at the translational level. Using the catRAPID approach to predict the propensity of proteins to bind to RNA, we investigated the occurrence of autogenous associations in the human proteome. Our algorithm correctly identified binding sites in well-known cases such as thymidylate synthase, tumor suppressor P53, synaptotagmin-1, serine/ariginine-rich splicing factor 2, heat shock 70 kDa, ribonucleic particle-specific U1A and ribosomal protein S13. In addition, we found that several other proteins are able to bind to their own mRNAs. A large-scale analysis of biological pathways revealed that aggregation-prone and structurally disordered proteins have the highest propensity to interact with cognate RNAs. These findings are substantiated by experimental evidence on amyloidogenic proteins such as TAR DNA-binding protein 43 and fragile X mental retardation protein. Among the amyloidogenic proteins, we predicted that Parkinson’s disease-related α-synuclein is highly prone to interact with cognate transcripts, which suggests the existence of RNA-dependent factors in its function and dysfunction. Indeed, as aggregation is intrinsically concentration dependent, it is possible that autogenous interactions play a crucial role in controlling protein homeostasis.
Preschoolers' use of abstract individual identity in inductive inference

ii PREFACE . iv TABLE OF CONTENTS . v LIST OF TABLES . vii LIST OF FIGURES . viii ACKNOWLEDGMENTS . ix INTRODUCTION . 1 Terminology . 4 Background . 5 Multiply Instantiated Abstract Individuals . 6 Conceptual Flexibility & Inductive Inference . 10 Children‘s Sensitivity to Property Origins . 17 Summary of Experiments . 19 EXPERIMENT 1 . 23 Method . 23 Participants . 23 Materials . 23 Procedure . 25 Results . 29 ANOVA Analysis . 29 Comparison to Chance . 30 Nonparametric Analysis of Individual Response Patterns. 31 Discussion . 32 EXPERIMENT 2 . 33 Method . 34 Participants . 34 Materials . 34 Procedure . 35 Practice Phase. 35 Storybook Phase. 37 Results . 40 ANOVA Analysis . 40
Temporal relation between top-down and bottom-up processing in lexical tone perception

Speech perception entails both top-down processing that relies primarily on language experience and bottom-up processing that depends mainly on instant auditory input. Previous models of speech perception often claim that bottom-up processing occurs in an early time window, whereas top-down processing takes place in a late time window after stimulus onset. In this paper, we evaluated the temporal relation of both types of processing in lexical tone perception. We conducted a series of event-related potential (ERP) experiments that recruited Mandarin participants and adopted three experimental paradigms, namely dichotic listening, lexical decision with phonological priming, and semantic violation. By systematically analyzing the lateralization patterns of the early and late ERP components that are observed in these experiments, we discovered that: auditory processing of pitch variations in tones, as a bottom-up effect, elicited greater right hemisphere activation; in contrast, linguistic processing of lexical tones, as a top-down effect, elicited greater left hemisphere activation. We also found that both types of processing co-occurred in both the early (around 200 ms) and late (around 300–500 ms) time windows, which supported a parallel model of lexical tone perception. Unlike the previous view that language processing is special and performed by dedicated neural circuitry, our study have elucidated that language processing can be decomposed into general cognitive functions (e.g., sensory and memory) and share neural resources with these functions.
Sexual Assault: Pattern and Related Complications among Cases Managed in Jimma University Specialized Hospital

Background Sexual assault affects one out of every five women, and it is a substantial public health and human rights problem in developing countries including Ethiopia. There has not been a study which documented the extent of the problem in the study area; hence the objective of this study was to assess the pattern of sexual assault and related complications in cases which were treated at Jimma University Specialized Hospital from November 1, 2011 – October 31, 2012. Methods A hospital based cross-sectional descriptive study was conducted with the aim of assessing sexual assault patterns and related complications on 99 sexual assault cases which were managed at the Gynecology Out-patient Department of the Hospital. Data on circumstances of sexual assault, survivor specific demographic characteristics and information on complications and interventions provided were collected by trained third year residents in obstetrics and gynecology using pretested questionnaire after respondent consent was taken. The collected data was cleaned, edited, fed into computer and analyzed using SPSS for windows version 16.0. Results The mean (±SD) of the survivors' age was 14 (±5) years; 57.5% of the survivors were children and 68.7% were from rural areas. Three percent of the clients visited the Gynecology Outpatient Department for sexual assault where rape accounted for 78.8%. The majority (76.8%) of the assailants was known to the survivors, 91% were assaulted by one assailant and 5.1% of the rape cases were gang rape. The mean time of presentation after sexual assault to the hospital was 15 days. Survivors had pregnancy test, HIV test and screening for sexually transmitted infections in 76.8%, 99%, 93% respectively of which 17.1%, 5.1%, 14.1% tested positive for pregnancy, HIV, and some STIs respectively. All HIV positive survivors were children under fifteen years of age. Forty percent of the survivors were provided with emergency contraception. In addition, 60.5%, 63%, and 91.9% of them were provided with post-exposure prophylaxis for HIV, STIs prophylaxis and were given counseling respectively. Conclusion It has been revealed that sexual assault is a major problem of women and children of less than fifteen years. There were gaps in providing and receiving packages of care and justice system to protect survivors indicating the needs for community intervention and providing quality of care by health care staff.
Neural signature of the conscious processing of auditory regularities

Can conscious processing be inferred from neurophysiological measurements? Some models stipulate that the active maintenance of perceptual representations across time requires consciousness. Capitalizing on this assumption, we designed an auditory paradigm that evaluates cerebral responses to violations of temporal regularities that are either local in time or global across several seconds. Local violations led to an early response in auditory cortex, independent of attention or the presence of a concurrent visual task, whereas global violations led to a late and spatially distributed response that was only present when subjects were attentive and aware of the violations. We could detect the global effect in individual subjects using functional MRI and both scalp and intracerebral event-related potentials. Recordings from 8 noncommunicating patients with disorders of consciousness confirmed that only conscious individuals presented a global effect. Taken together these observations suggest that the presence of the global effect is a signature of conscious processing, although it can be absent in conscious subjects who are not aware of the global auditory regularities. This simple electrophysiological marker could thus serve as a useful clinical tool.
Functional MRI Activation of Inhibitory Control in Adolescents and Young Adults with Multiple Sclerosis

ii Acknowledgements iv Table of Contents v List of Tables vii List of Figures viii List of Abbreviations ix Introduction 1 Overview of Multiple sclerosis 2 Cognitive Impairment in Pediatric-­‐Onset Multiple Sclerosis 3 Relating brain damage to adaptive functional reorganization in patients with MS 7 Attentional control and Response Inhibition 13 Purpose 21 Objective 1. To examine response inhibition in pediatric-­‐onset MS patients and age-­‐ matched controls using a simple Go/No-­‐go task 22 Objective 2. To evaluate the influence of age at disease onset and cerebral tissue damage on Go/No-­‐go performance parameters 22 Objective 3. To examine whether cognitively intact childhood-­‐onset MS patients produce a less efficient pattern of cerebral activation compared with age-­‐matched healthy controls 22 Method 23