Miracle-dz/UniFAR-FTUs huggingface dataset:
Correction of anemia with epoetin alfa in chronic kidney disease.

BACKGROUND Anemia, a common complication of chronic kidney disease, usually develops as a consequence of erythropoietin deficiency. Recombinant human erythropoietin (epoetin alfa) is indicated for the correction of anemia associated with this condition. However, the optimal level of hemoglobin correction is not defined. METHODS In this open-label trial, we studied 1432 patients with chronic kidney disease, 715 of whom were randomly assigned to receive a dose of epoetin alfa targeted to achieve a hemoglobin level of 13.5 g per deciliter and 717 of whom were assigned to receive a dose targeted to achieve a level of 11.3 g per deciliter. The median study duration was 16 months. The primary end point was a composite of death, myocardial infarction, hospitalization for congestive heart failure (without renal replacement therapy), and stroke. RESULTS A total of 222 composite events occurred: 125 events in the high-hemoglobin group, as compared with 97 events in the low-hemoglobin group (hazard ratio, 1.34; 95% confidence interval, 1.03 to 1.74; P=0.03). There were 65 deaths (29.3%), 101 hospitalizations for congestive heart failure (45.5%), 25 myocardial infarctions (11.3%), and 23 strokes (10.4%). Seven patients (3.2%) were hospitalized for congestive heart failure and myocardial infarction combined, and one patient (0.5%) died after having a stroke. Improvements in the quality of life were similar in the two groups. More patients in the high-hemoglobin group had at least one serious adverse event. CONCLUSIONS The use of a target hemoglobin level of 13.5 g per deciliter (as compared with 11.3 g per deciliter) was associated with increased risk and no incremental improvement in the quality of life. (ClinicalTrials.gov number, NCT00211120 [ClinicalTrials.gov].).
Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo.

The antitumor and radiosensitizing effects of withaferin A (WA), a steroidal lactone from Withania somnifera, was studied on Ehrlich ascites carcinoma in vivo. The acute LD50(14) for WA in Swiss mice was approximately 80 mg/kg. Twenty-four hours after i.p. inoculation of 10(6) tumor cells, WA was injected i.p. at different dose fractions (5 or 7.5 mg/kg x 8, 10 mg/kg x 5, 20 or 30 mg/kg x 2) with or without abdominal gamma irradiation (RT, 75. Gy) after the first drug dose. Increase in life span and tumor-free survival were studied up to 120 days. The drug inhibited tumor growth and increased survival, which was dependent on the WA dose per fraction rather than the total dose. Combination of RT with all the drug schedules increased tumor cure and tumor-free survival, the best effect seen after 2 fractions of 30 mg/kg each. In another experiment WA was given as 2 (40 mg/kg x 2), 3 (30 mg/kg x 3) or 4 (20 mg/kg x 4) fractions at 5, 7 or 10 days after tumor inoculation with or without RT after the first drug dose. At 7 and 10 days after inoculation the drug was effective only at 40 mg/kg x 2, but with RT 30 mg/kg x 3 produced an equal effect (20% survival) on 7 day old tumors.
THE COMPARATIVE EFFECT OF EXPLICIT FOCUS ON FORM AND DICTOGLOSS TASK ON LEARNING ENGLISH TENSES

This study intended to compare the impact of two output-oriented focus-onform types of instruction namely explicit focus on form (EFF) and dictogloss (DG) tasks on helping beginning EFL learners learn English tenses. The participants were 64 female EFL learners randomly assigned to two groups with each group receiving a different kind of instruction. Their knowledge of grammar was assessed through the placement test of the language school which showed that the two groups were homogeneous in terms of their language proficiency. Besides, a test of English tenses proved that the participants had little knowledge of tenses. Accordingly, the grammatical points were taught to both groups throughout the course. Teaching style in each group differed according to the type of technique used in each class. After the treatment period, the two groups took a posttest, the results of which showed that the difference between the two groups was not statistically significant. One highly probable pedagogical implication of the study is that both EFF and DG are effective pedagogical tools in helping beginning EFL learners learn target grammatical forms.
The Contribution of the Potential for Evaluation to Coaction Effects

Previous research on social facilitation (e.g. Harkins, 1987) has made it clear that the potential for evaluation plays a role in producing coaction effects, but has left unclear the source of these effects. Subsequent research (e.g. Szymanski & Harkins, 1987, 1993) has shown that the potential for self-evaluation and experimenter evaluation each produce performance greater than that found in a `no evaluation' control group. However, the combination of these sources produces performance no better than either taken alone. In Experiment 1, we show that the potential for evaluation by a coactor also produces performance better than that found in a `no evaluation' control group, and that the combination of these sources (coactor plus self) also produces performance no better than either taken alone. Experiment 2 shows that the combination of the potential for evaluation by the experimenter and a coactor does produce better performance than either source taken alone. These findings suggest that, although adding external sources of evaluation contributes to the potency of the coaction effect, adding the potential for self-evaluation to the potential for evaluation by external sources does not.
Application of femtosecond ultrashort pulse laser to photodynamic therapy mediated by indocyanine green

Backgrounds/aims: To evaluate treatment with high peak power pulse energy by femtosecond ultrashort pulse laser (titanium sapphire laser) delivered at an 800 nm wavelength for corneal neovascularisation using photodynamic therapy (PDT) mediated by indocyanine green (ICG). Methods: Using a gelatin solid as an in vitro corneal model, the safety of laser power was studied to determine if it degenerated gelatin with or without ICG. The authors then induced corneal neovascularisation in rabbit eyes by an intracorneal suturing technique. Fluorescein angiography was used to evaluate occlusion before PDT and 0, 1, 3, and 10 days after PDT. The authors performed light microscopy with haematoxylin eosin staining and transmission electron microscopy to determine thrombosis formation in the neovascular regions. Results: The threshold of peak laser power density ranged from 39 to 53 W/cm2. Laser irradiation was started 30 seconds after a 10 mg/kg ICG injection, and all irradiated segments were occluded at 0, 1, 3, and 10 days at 3.8 J/cm2. Light and electron microscopy documented thrombosis formation in the neovascular region. Conclusion: Femtosecond pulse laser enhanced by ICG can be used for PDT. Because of effective closure of corneal neovascularisation at a low energy level, the high peak power pulse energy of the femtosecond pulse laser might be more efficacious than continuous wave laser for use with PDT.
The neural correlates of orienting: An integration of fMRI and skin conductance orienting

In fMRI studies, the averaging of neural activity across multiple trials might obscure important psychophysiological subprocesses. The orienting response (OR) is a distinctive subprocess signalling the active orientation of attention towards potentially significant events. We sought to elucidate fMRI activity associated with visual stimuli that did or did not evoke simultaneously recorded electrodermal ORs (using customised skin conductance recording). ‘With-OR’ stimuli were associated with significant activity in the hippocampus, anterior cingulate and ventromedial prefrontal cortex. Averaged analysis revealed activity only in the expected visual circuits. Our results suggest that potentially significant stimuli (with-OR) activate different functional networks to familiar (without-OR) stimuli, and that orienting may therefore be an informative subprocess to consider in cognitive fMRI studies.
Learning and Knowledge Transfer with Memory Networks for Machine Comprehension

Enabling machines to read and comprehend unstructured text remains an unfulfilled goal for NLP research. Recent research efforts on the “machine comprehension” task have managed to achieve close to ideal performance on simulated data. However, achieving similar levels of performance on small real world datasets has proved difficult; major challenges stem from the large vocabulary size, complex grammar, and, the frequent ambiguities in linguistic structure. On the other hand, the requirement of human generated annotations for training, in order to ensure a sufficiently diverse set of questions is prohibitively expensive. Motivated by these practical issues, we propose a novel curriculum inspired training procedure for Memory Networks to improve the performance for machine comprehension with relatively small volumes of training data. Additionally, we explore various training regimes for Memory Networks to allow knowledge transfer from a closely related domain having larger volumes of labelled data. We also suggest the use of a loss function to incorporate the asymmetric nature of knowledge transfer. Our experiments demonstrate improvements on Dailymail, CNN, and MCTest datasets.
Meat Mutagens and Risk of Distal Colon Adenoma in a Cohort of U.S. Men

Cooking meats at high temperatures and for long duration produces heterocyclic amines and other mutagens. These meat-derived mutagenic compounds have been hypothesized to increase risk of colorectal neoplasia, but prospective data are unavailable. We examined the association between intakes of the heterocyclic amines 2-amino-3,8-dimethylimidazo[4,5,-f]quinoxaline (MeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,4,8-trimethylimidazo[4,5,-f]quinoxaline (DiMeIQx), and meat-derived mutagenicity (MDM) and risk of distal colon adenoma using a cooking method questionnaire administered in 1996 in the Health Professionals Follow-up Study cohort. Between 1996 and 2002, 581 distal colon adenoma cases were identified. Higher intake of MDM was marginally associated with increased risk of distal adenoma [fourth versus lowest quintile: odds ratio (OR), 1.39; 95% confidence interval (95% CI), 1.05-1.84; highest versus lowest quintile: OR, 1.29; 95% CI, 0.97-1.72; Ptrend = 0.08]. Adjusting for total red meat or processed meat intake did not explain those associations. Our data also suggested a positive association between higher MeIQx (highest versus lowest quintile: OR, 1.28; 95% CI, 0.95-1.71; Ptrend = 0.22) and risk of adenoma, but this association was attenuated after adjusting for processed meat intake. DiMeIQx and PhIP did not seem to be associated with risk of adenoma. In conclusion, higher consumption of mutagens from meats cooked at higher temperature and longer duration may be associated with higher risk of distal colon adenoma independent of overall meat intake. Because mutagens other than heterocyclic amines also contribute to MDM, our results suggest that mutagens other than heterocyclic amines in cooked meats may also play a role in increasing the risk of distal adenoma. (Cancer Epidemiol Biomarkers Prev 2006;15(6):1120–5)
The influence of workplace spirituality on motivations for earnings management: a study in Taiwan's hospitality industry.

The paper attempts to examine the influences on motivations for earnings management from the perspectives of workplace spirituality in Taiwan’s hospitality industry. The findings suggest that workplace spirituality is a new perception of individuals toward their lives and selves under the influence of the workplace. Such influence further affects the individuals on the acknowledgement of self-group relationships, and the actions of individuals. Therefore, spiritual awareness shows a mediating effect between organizational spirituality and earnings management. Moreover, the mediating effect is greater than the direct effect of organizational spirituality on the motivations of earnings management. In addition, this paper proves that there are no significant variances in the awareness of workplace spirituality among people who have different religious beliefs. Most literatures address earnings management from the perspectives of audits or business ethics, and suggest that moral education is the best way to cope with this issue. However, a sole reliance on the awaking and realization of the individual ethics may not be sufficient to amend current chaotic situations regarding earnings management. In fact, earnings management, in essence, is highly relevant to the opportunistic behaviors of management. Key words: Earnings management, workplace spirituality, motivations for earnings management.
Attribution Processes in Cross-Cultural Heritage Tourism

ABSTRACT This article, utilizing a mixed methods approach, examines psychological processes of some global Jewish tourists and local hosts surrounding historic Holocaust sites located in Europe. These processes, which include stereotyping, the perseverance effect, and the role of atypical information, generate insights into social-psychological activity nested in cross-cultural tourism. Our research yields significant implications on collective memory and narrative and marketing management. It also indicates that current Holocaust tourism and its related marketing strategies can lead to further disconnect between tourists and hosts in Eastern Europe.
The Key to Global Understanding: World Languages Education—Why Schools Need to Adapt

This review article is a plea for the education community to reconsider the place of world languages teaching within the schools. With globalization, languages education should be one of the strategic goals of public as well as private education. The article reviews research on the best age level for learning a language, the assets of bilingualism, the problems that arise from lack of recognition for other languages and cultures, the ways to change current language education, and the integration of international language policies. The literature reviewed points at how the issues discussed can be resolved to increase global understanding.
Bird and bat predation services in tropical forests and agroforestry landscapes

Understanding distribution patterns and multitrophic interactions is critical for managing bat‐ and bird‐mediated ecosystem services such as the suppression of pest and non‐pest arthropods. Despite the ecological and economic importance of bats and birds in tropical forests, agroforestry systems, and agricultural systems mixed with natural forest, a systematic review of their impact is still missing. A growing number of bird and bat exclosure experiments has improved our knowledge allowing new conclusions regarding their roles in food webs and associated ecosystem services. Here, we review the distribution patterns of insectivorous birds and bats, their local and landscape drivers, and their effects on trophic cascades in tropical ecosystems. We report that for birds but not bats community composition and relative importance of functional groups changes conspicuously from forests to habitats including both agricultural areas and forests, here termed ‘forest‐agri’ habitats, with reduced representation of insectivores in the latter. In contrast to previous theory regarding trophic cascade strength, we find that birds and bats reduce the density and biomass of arthropods in the tropics with effect sizes similar to those in temperate and boreal communities. The relative importance of birds versus bats in regulating pest abundances varies with season, geography and management. Birds and bats may even suppress tropical arthropod outbreaks, although positive effects on plant growth are not always reported. As both bats and birds are major agents of pest suppression, a better understanding of the local and landscape factors driving the variability of their impact is needed.
Do attitudes toward lesbians and gay men differ among heterosexual collegiate student-athletes and student non-athletes?

by Milton R. Dawkins Jr. The aim of the present study was to explore attitude differences among heterosexual collegiate student-athletes and heterosexual collegiate student non-athletes. Attitudes were assessed in relation to 5 variables. The variables included gender, contact (with lesbians and gay men), educational level, religiosity, and sport (athletes versus non-athletes). The Attitudes Toward Lesbians and Gay Men scale (Herek & McLemore, 2011) was used to assess attitudes toward lesbians and gay men, and a demographic questionnaire was employed to collect demographic information. The studied revealed that student-athletes held more negative attitudes toward lesbians and gay men than did student non-athletes. The variables gender, contact (with lesbians and gay men), and religiosity were related to attitudes toward lesbians and gay men. It was revealed that educational level was not associated with attitudes toward lesbians and gay men in the current study.
Improved diagnosis of mycobacterial infections in formalin‐fixed and paraffin‐embedded sections with nested polymerase chain reaction

Traditional histological diagnosis of mycobacterial infection in formalin‐fixed and paraffin‐embedded (FFPE) tissues is insensitive and poorly specific. To improve this, we developed nested polymerase chain reaction (PCR) protocols for detecting a Mycobacterium genus‐specific 65‐kDa heat shock protein (HSP65) sequence and the M. tuberculosis complex‐specific insertion sequence IS6110 in FFPE sections. Protocols were optimized on tissues from 20 patients with a final clinical diagnosis of mycobacterial infection. Amplicons were controlled by sequencing and restriction endonuclease digestion. PCR could detect as few as three mycobacterial genomes per reaction. Assays showed 100% sensitivity and specificity for both M. tuberculosis complex and M. avium complex infection. Paraffin blocks from a second group of 26 patients with histological evidence of necrotizing granulomas of unknown etiology were then analyzed as a surrogate group to test the assay under conditions similar to those applying during routine diagnosis. Twenty‐three of these blocks contained amplifiable DNA; nine were positive for M. tuberculosis complex DNA and four for other types of mycobacterial DNA. Furthermore, digestion of HSP65 amplicons with NarI could distinguish M. tuberculosis from M. avium complex. In conclusion, our nested PCR assays can be used as reliable tools for the detection of mycobacterial infections in FFPE tissues. The assays are simple and rapid to perform and show improved sensitivity and specificity compared to previously reported protocols.
Risk of second primary cancers after Hodgkin's disease by type of treatment: analysis of 2846 patients in the British National Lymphoma Investigation.

OBJECTIVE--To analyse the risk of second primary cancers during long term follow up of patients with Hodgkin's disease. DESIGN--Cohort study. SETTING--The British National Lymphoma Investigation (a collaborative group of over 60 participating centres in Britain treating lymphomas). PATIENTS--2846 patients first treated for Hodgkin's disease during 1970-87, for whom follow up was complete in 99.8%. MAIN OUTCOME MEASURES--Second primary cancers; uniform pathology reviews confirmed the diagnosis of Hodgkin's disease and of second primary non-Hodgkin's lymphomas. RESULTS--113 second primary cancers occurred. Relative risk of cancer other than Hodgkin's disease was 2.7 (95% confidence interval 2.3 to 3.3) compared with the general population, with significant risk of leukaemia (16.0(9.1 to 26.0)); non-Hodgkin's lymphoma (16.8(9.8 to 26.9)); and cancers of the colon (3.2 (1.4 to 6.2)), lung (3.8 (2.6 to 5.4)), bone (15.1 (1.8 to 54.7)), and thyroid (9.4 (1.1 to 33.9)). Absolute excess risk associated with treatment was greater for solid tumours than for leukaemia and lymphomas. Relative risk of leukaemia increased soon after treatment, reaching a peak after five to nine years. It was increased substantially after chemotherapy (27.9 (12.7 to 52.9)), combined treatment with radiotherapy and chemotherapy (21.5 (7.9 to 46.8)), and relative to number of courses of chemotherapy but was not significantly increased after radiotherapy (2.5 (0.1 to 14.1)). Relative risk of non-Hodgkin's lymphoma increased in the first five years after treatment and remained high but showed no clear relation with type or extent of treatment. Relative risk of solid tumours was less raised initially but increased throughout follow up and for lung cancer 10 years or more after entry was 8.3 (4.0 to 15.3). The risk of solid tumours increased after treatments including radiotherapy and after chemotherapy alone. The risk after chemotherapy increased significantly with time since first treatment. CONCLUSION--The risk of solid cancer, not of leukaemia, is the major long term hazard of treatment for Hodgkin's disease, and this seemed to apply after chemotherapy as well as after radiotherapy. These risks of second cancers are important in choice of treatment and in follow up of patients, but they are small compared with the great improvements in survival which have been brought about by modern therapeutic methods for Hodgkin's disease.
Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice.

BACKGROUND DMT1 (Nramp2/DCT1) is the major apical iron transporter in absorptive cells of the duodenum, but also transports transferrin-iron across the membrane of acidified endosomes in peripheral tissues. DMT1 mRNA and protein expression has been detected in rat and mouse kidney, but its role at that site remains to be clarified. METHODS Immunoblotting and immunohistochemistry with specific affinity purified anti-DMT1 polyclonal antibodies were used to study expression and localization of DMT1 in mouse kidney. Possible regulation of DMT1 protein expression by the body iron stores also was examined in normal mice deprived of dietary iron, and in the genetically anemic mk mice that bear a loss of function mutation at DMT1 (G185R). RESULTS In microsomal kidney fractions, DMT1 isoform I (encoded by the iron responsive element (IRE)-containing mRNA) is detected as an abundant 70 to 75 kD membrane protein. DMT1 is expressed in the cortex and not in the medulla, and is present at the brush border and apical pole of epithelial cells of proximal tubules. In contrast to the intestine, DMT1 protein expression in kidney is only slightly increased upon deprivation of dietary iron, suggesting different regulation at the two sites. In kidneys from mk/mk mice, the level of detectable DMT1(G185R) protein is drastically decreased compared to mk/+ controls. CONCLUSION These results suggest that DMT1 may act as a re-uptake system for divalent cations at the brush border of kidney proximal tubules. A pathological mutation at DMT1 affects targeting/expression of the protein in the kidney.
“To listen or to read?” Audio or written assessment feedback for international students in the UK

Purpose – In response to the less satisfied National Student Survey, UK universities have committed to transform assessment and feedback experience. This paper aims to explore how the diversity of online assessment and feedback offer a better learning experience for international students. Design/methodology/approach – By using the action research method, the research investigated academic and international students' first experience on audio feedback and online text. Video interviews and online questionnaires were carried out. Findings – All research participants would like to receive assessment feedback in audio form. This reflects the learning experience of students and suggests that the support of a higher educational institution or a tutor could provide for assessment and feedback enhancement in the digital world is mandatory. Other than the technological and instrumental advantage, the “human element” of audio feedback makes it unique and interesting to listen to in contrast to online written feedba.