Miracle-dz/UniFAR-FTUs huggingface dataset:
Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis.

PURPOSE The purpose of this study was to determine whether expression of migration inhibitory factor (MIF) is increased in non-small cell lung cancer, and whether it correlates with angiogenesis and/or prognosis. EXPERIMENTAL DESIGN We measured vessel density, and levels of MIF, angiogenic CXC chemokines, and vascular-endothelial growth factor (VEGF; by ELISA) in tumor and normal lung tissue from 87 patients after resection of lung cancer. We compared vessel density with levels of MIF, VEGF, or angiogenic CXC chemokines in the corresponding tumor homogenate. Disease-free survival was analyzed in a Cox proportional hazards model. RESULTS Levels of MIF in lung cancer demonstrated a bimodal distribution, with some having "normal" values (relative to normal lung tissue) and a second cluster with markedly high values. The increased levels of MIF in lung cancer were statistically significant in both paired and unpaired comparisons (P < 0.05). The strongest correlation of vessel density was with the sum of angiogenic CXC chemokines. MIF correlated very strongly with levels of angiogenic CXC chemokines. Tumors in the high MIF group had a strong correlation between MIF level and vessel density. Risk of recurrence was associated with high levels of glutamic acid-leucine-arginine amino acid motif CXC chemokines, MIF, and/or VEGF in a Cox proportional hazards model. CONCLUSIONS MIF expression in non-small cell lung cancer occurs in a bimodal distribution, and is closely associated with tumor levels of angiogenic CXC chemokines and with vessel density. High levels of tumor-associated CXC chemokines, MIF, or VEGF are associated with risk of recurrence after resection of lung cancer.
Developmental Trajectory of Information-Processing Skills in Children: Computer-Based Assessment

There are significant merits to a comprehensive cognitive assessment, but they are also time-consuming, costly, and susceptible to practice effects and may not detect change in the context of medical interventions or minor brain disruptions. Brief computer-based assessments focused on “fluid” cognitive domains (e.g., information-processing skills), which are vulnerable to disruption as a result of a brain injury, may provide an alternative assessment option. This study sought to: (a) examine the utility of a well-established, adult-based computerized tool, CogSport for Kids (CogState), for evaluating information-processing skills in children and adolescents; and (b) to report normative data for healthy children and adolescents. The study was a cross-sectional, community-based observational study of typically developing children aged 9 to 17 years old (N = 832). Participants completed the CogSport for Kids test battery, which includes six brief computerized tasks that assess cognitive functions including processing speed, attention, and working memory. Results showed an improvement with age for response speed and accuracy. The greatest change occurred between 9 and 12 years with performance stabilizing at 15 years. This brief screening tool is appropriate for clinical and research use in children aged 9 years and older and may be used to track cognitive development from childhood into adulthood and to identify children who deviate from normal expectations.
Autonomy Support and Intrinsic Goal Progress Expectancy and Its Links to Longitudinal Study Effort and Subjective Wellbeing: The Differential Mediating Effect of Intrinsic and Identified Regulations and the Moderator Effects of Effort and Intrinsic Goals

The authors tested a self-determination theory (Deci & Ryan, 2000) process model of subjective wellbeing among students at Norwegian Folk High Schools. In this model the authors hypothesized that students' intrinsic goal progress expectancy in the chosen study activity and perceived autonomy support from teachers would be positively associated with intrinsic and identified regulations of activity. In turn, intrinsic regulation would positively affect subjective wellbeing at the end of the school year (eight months later), whereas the identified regulation–subjective wellbeing link would be both indirect through and moderated by effort. In addition, the lower the identified regulation among students, the more their psychological well-being would be moderated by intrinsic goal progress expectancy. The results supported all predictions.
Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma

Forkhead transcription factor (Foxo3a) is a downstream effector of JNK-induced tumor suppression. However, it is not clear whether the caveolin-1 (CAV1)-mediated JNK/Foxo3a pathway is involved in cancer cell apoptosis. We found that cordycepin upregulates CAV1 expression, which was accompanied by JNK phosphorylation (p-JNK) and subsequent Foxo3a translocation into the nucleus, resulting in the upregulation of Bax protein expression. Furthermore, we found that CAV1 overexpression upregulated p-JNK, whereas CAV1 siRNA downregulated p-JNK. Additionally, SP600125, a specific JNK inhibitor, significantly increased Foxo3a phosphorylation, which downregulated Foxo3a translocation into the nucleus, indicating that CAV1 mediates JNK regulation of Foxo3a. Foxo3a siRNA downregulated Bax protein and attenuated A549 apoptosis, indicating that the CAV1-mediated JNK/Foxo3a pathway induces the apoptosis of A549 lung cancer cells. Cordycepin significantly decreased tumor volume in nude mice. Taken together, these results indicate that cordycepin promotes CAV1 upregulation to enhance JNK/Foxo3a signaling pathway activation, inducing apoptosis in lung cancer cells, and support its potential as a therapeutic agent for lung cancer.
Interferon Regulatory Factor 1 Polymorphisms Previously Associated with Reduced HIV Susceptibility Have No Effect on HIV Disease Progression

Introduction Interferon regulatory factor 1 (IRF1) is induced by HIV early in the infection process and serves two functions: transactivation of the HIV-1 genome and thus replication, and eliciting antiviral innate immune responses. We previously described three IRF1 polymorphisms that correlate with reduced IRF1 expression and reduced HIV susceptibility. Objective To determine whether IRF1 polymorphisms previously associated with reduced HIV susceptibility play a role in HIV pathogenesis and disease progression in HIV-infected ART-naïve individuals. Methods IRF1 genotyping for polymorphisms (619, MS and 6516) was performed by PCR in 847 HIV positive participants from a sex worker cohort in Nairobi, Kenya. Rates of CD4+ T cell decline and viral loads (VL) were analyzed using linear mixed models. Results Three polymorphisms in the IRF1, located at 619, microsatellite region and 6516 of the gene, previously associated with decreased susceptibility to HIV infection show no effect on disease progression, either measured by HIV-1 RNA levels or the slopes of CD4 decline before treatment initiation. Conclusion Whereas these three polymorphisms in the IRF1 gene protect against HIV-1 acquisition, they appear to exert no discernable effects once infection is established.
Learning-to-Rank in Research Paper CBF recommendation: Leveraging Irrelevant Papers

Suggesting relevant literature to researchers has become an active area of study, typically relying on content-based ﬁl-tering (CBF) over the rich textual features available. Given the high dimensionality and the sparsity of the training samples inherent to this domain, the focus has so far been on heuristic-based methods. In this paper, we argue for the model-based approach and propose a learning-to-rank method that leverages publicly available publications’ meta-data to produce an eﬀective prediction model. The proposed method is systematically evaluated on a scholarly paper recommendation dataset and compared against state-of-the-art model-based approaches as well as current, domain-speciﬁc heuristic methods. The results show that our approach clearly outperforms state-of-the-art research paper recommendations utilizing only publicly available meta-data.
Características psicométricas de la Escala de Conectividad con la Naturaleza en una muestra universitaria

Resumen La Conectividad con la Naturaleza se define como la forma en que las personas incluyen a la naturaleza como parte de su propia representación cognitiva. Uno de los instrumentos que mide dicha conexión es la Escala de Conectividad con la Naturaleza de Mayer y Frantz (2004). En este estudio se analizan las propiedades psicométricas, en cuanto a fiabilidad y validez (análisis factorial exploratorio y confirmatorio) de una versión en español de la Escala, en una muestra de 430 estudiantes universitarios. Los resultados obtenidos muestran un factor principal que indicaría el grado de conexión con el entorno natural. Se revisa el propio concepto de conectividad.
Olive Crown Porosity Measurement Based on Radiation Transmittance: An Assessment of Pruning Effect

Crown porosity influences radiation interception, air movement through the fruit orchard, spray penetration, and harvesting operation in fruit crops. The aim of the present study was to develop an accurate and reliable methodology based on transmitted radiation measurements to assess the porosity of traditional olive trees under different pruning treatments. Transmitted radiation was employed as an indirect method to measure crown porosity in two olive orchards of the Picual and Hojiblanca cultivars. Additionally, three different pruning treatments were considered to determine if the pruning system influences crown porosity. This study evaluated the accuracy and repeatability of four algorithms in measuring crown porosity under different solar zenith angles. From a 14° to 30° solar zenith angle, the selected algorithm produced an absolute error of less than 5% and a repeatability higher than 0.9. The described method and selected algorithm proved satisfactory in field results, making it possible to measure crown porosity at different solar zenith angles. However, pruning fresh weight did not show any relationship with crown porosity due to the great differences between removed branches. A robust and accurate algorithm was selected for crown porosity measurements in traditional olive trees, making it possible to discern between different pruning treatments.
Up‐regulation of the phosphoinositide 3‐kinase pathway in human lamina propria T lymphocytes

Human intestinal lamina propria T lymphocytes (LPT), when investigated ex vivo, exhibit functional properties profoundly different from those of peripheral blood T lymphocytes (PBT). One prominent feature represents their enhanced sensitivity to CD2 stimulation when compared to PBT. Given that LPT are hyporesponsive to T cell receptor (TCR)/CD3 stimulation, an alternative activation mode, as mimicked by CD2 triggering in vitro, may be functional in mucosal inflammation in vivo. This study provides insight into signalling events associated with the high CD2 responsiveness of LPT. When compared to PBT, LPT show an increased activation of the phosphoinositide 3/protein kinase B/glycogen synthase kinase 3β (PI3‐kinase/AKT/GSK‐3β) pathway in response to CD2 stimulation. Evidence is provided that up‐regulation of this pathway contributes to the enhanced CD2‐induced cytokine production in LPT. Given the importance of TCR‐independent stimulation for the initiation of intestinal immune responses analysis of signalling pathways induced by ‘co‐stimulatory’ receptors may provide valuable information for therapeutic drug design.
Carrageenan Gum and Adherent Invasive Escherichia coli in a Piglet Model of Inflammatory Bowel Disease: Impact on Intestinal Mucosa-associated Microbiota

Inflammatory bowel diseases (IBD) including Crohn's disease (CD), and ulcerative colitis (UC), are chronic conditions characterized by chronic intestinal inflammation. Adherent invasive Escherichia coli (AIEC) pathotype has been increasingly implicated in the etiopathogenesis of IBD. In a 21-day study, we investigated the effects of AIEC strain UM146 inoculation on microbiota profile of the ileal, cecal, ascending and descending colon in a pig model of experimental colitis. Carrageenan gum (CG) was used to induce colitis in weaner piglets whereas AIEC strain UM146 previously isolated from a CD patient was included to investigate a cause or consequence effect in IBD. Treatments were: (1) control; (2) CG; (3) AIEC strain UM146; and (4) CG+UM146. Pigs in groups 2 and 4 received 1% CG in drinking water from day 1 of the study while pigs in groups 3 and 4 were inoculated with UM146 on day 8. Following euthanization on day 21, tissue mucosal scrapings were collected and used for DNA extraction. The V4 region of bacterial 16S rRNA gene was then subjected to Illumina sequencing. Microbial diversity, composition, and the predicted functional metagenome were determined in addition to short chain fatty acids profiles in the digesta and inflammatory cytokines in the intestinal tissue. CG-induced colitis decreased bacterial species richness and shifted community composition. At the phylum level, an increase in Proteobacteria and Deferribacteres and a decrease in Firmicutes, Actinobacteria, and Bacteroidetes were observed in CG and CGUM146 compared to control and UM146. The metabolic capacity of the microbiome was also altered in CG and CGUM146 compared to UM146 and control in the colon. We demonstrated that CG resulted in bacterial dysbiosis and shifted community composition similar to what has been previously observed in IBD patients. However, AIEC strain UM146 alone did not cause any clear changes compared to CG or control in our experimental IBD pig model.
Interleaved High-Conversion-Ratio Bidirectional DC–DC Converter for Distributed Energy-Storage Systems—Circuit Generation, Analysis, and Design

This paper presents a novel interleaved high-conversion-ratio bidirectional DC-DC converter based on switched capacitors and coupled inductors. Series-connected switched capacitor and inductor cells were used to increase the voltage conversion ratio, reduce voltage stresses on power switches, realize soft-charging/discharging of switched capacitors, and achieve autocurrent-sharing in parallel inductors. The interleaved structure combined with switched capacitors was adopted to reduce current ripple at the side having lower voltage, thus enabling applications that require high power levels. In this paper, we first review the status of high-voltage-ratio bidirectional dc-dc converters. Then, the evolution of the proposed extensible topologies and the steady-state operating principle under the inductor current continuous conduction mode is presented. Finally, the performance and features such as voltage gain, voltage and current stress, and the autocurrent-sharing mechanism that are realized by switched capacitors are verified; the optimal design of coupled-inductors, switched-capacitors, and the chip size of switches are given. A specific design of the driving circuit that facilitates actual applications is described. A 1-kW prototype converter, employing a hybrid configuration of SiC and Si mosfets, was constructed to verify the theoretical analysis, and achieved an optimal compromise between conversion efficiency and low cost.
Specific Capital and Vintage Effects on the Dynamics of Unemployment and Vacancies

In a reasonably calibrated Mortensen and Pissarides matching model, shocks to average labor productivity can account for only a small portion of the fluctuations in unemployment and vacancies (Shimer (2005a)). In this paper, the author argues that if vintage specific shocks rather than aggregate productivity shocks are the driving force of fluctuations, the model does a better job of accounting for the data. She adds heterogeneity in jobs (matches) with respect to the time the job is created in the form of different embodied technology levels. The author also introduces specific capital that, once adapted for a match, has less value in another match. In the quantitative analysis, she shows that shocks to different vintages of entrants are able to account for fluctuations in unemployment and vacancies and that, in this environment, specific capital is important to decreasing the volatility of the destruction rate of existing matches.
MDL Denoising

'The so-called denoising problem, relative to normal models for noise, is formalized such that "noise" is defined as the incompressible part in the data while the compressible part defines the meaningful information-bearing signal. Such a decomposition is effected by minimization of the ideal code length, called for by the minimum description length (MDL) principle, and obtained by an application of the normalized maximum-likelihood technique to the primary parameters, their range, and their number. For any orthonormal regression matrix, such as defined by wavelet transforms, the minimization can be done with a threshold for the squared coefficients resulting from the expansion of the data sequence in the basis vectors defined by the matrix.
L'harmonisation comptable internationale : d'un vagabondage comptable à l'autre

We can observe, from the middle of the 80s, that the big international groups of the European Union have been practicing the “standards shopping” by choosing the standards the most suited to their need, according to the market they wanted to be quoted on. In the first part of this study, we shall attempt to measure this “standards shopping” and its evolution from 1985 till 1999 by using the vector norms. In the second part, we shall ask the question if the accounting wandering does not always survive with the same dimension within the standards of the same referential (that of the IASB) because of various options left with the discretion of companies.
THE BEHAVIOR OF VIRULENT AND AVIRULENT STAPHYLOCOCCI IN THE TISSUES OF NORMAL MICE

The fate of hemolytic staphylococci injected intravenousiy into albino mice was followed by determining quantitatively the numbers of living organisms present in the various tissues at different intervals of time after infection. Irrespective of the strain of staphylococcus used, most of the organisms disappeared rapidly from the blood, liver, spleen, and kidneys. This was true even when the infective dose consisted of large numbers of virulent, coagulase-positive staphylococci, capable of producing a fatal disease in a high percentage of the infected mice. The initial rate of removal or destruction of staphylococci was particularly high in the lungs and kidneys. In all cases on the other hand, a few living staphylococci persisted in the various organs for several weeks after infection, even when the organisms were non-virulent and coagulase-negative. Although virulent as well as avirulent staphylococci were eliminated extremely rapidly and efficiently from the kidneys during the initial stage of infection, the microorganisms soon began to multiply in this organ, causing abscesses first detected in the cortex. Death of the animals infected with virulent cultures appeared to be due to the destruction of renal tissue by these abscesses. The abscesses caused by the avirulent strains eventually became sterile, and healed. No convincing difference could be recognized amongst seven strains in their resistance to the bactericidal power of the mouse tissues during the initial phase of the infection. In contrast, marked quantitative differences came to light in their subsequent behavior in the kidneys. The multiplication of the coagulase-negative staphylococci in this organ soon came to an end in all animals and never proceeded far enough to result in fatal disease. The staphylococci of a weakly coagulase-positive strain multiplied somewhat more extensively in the kidneys than did the coagulase-negative, but never sufficiently to cause the death of any animal within the period of observation of 1 month. The three coagulase-positive strains tested yielded the largest bacterial population in the kidneys and caused the death of many of the infected animals. These three virulent strains differed quantitatively amongst themselves with regard to both the rapidity and extent of their multiplication in the kidneys and the lethal power of a given infective dose. Taken together, the findings indicate that the hemolytic strains of staphylococci can be arranged in a continuous spectrum according to their ability to cause disease in albino mice. Although virulence for these animals appeared to be correlated with the production of coagulase, it did not seem to depend upon the ability of this substance to interfere with the bactericidal mechanisms of the mouse organs during the early phase of the infection. Virulence manifested itself chiefly by the production in the kidneys of progressive abscesses originating from the few staphylococci which were not destroyed during the initial bactericidal reaction.
Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response

Objective: Investigate the DNA damage and its cellular response in blood samples from both mother and the umbilical cord of pregnancies complicated by hyperglycemia. Methods: A total of 144 subjects were divided into 4 groups: normoglycemia (ND; 46 cases), mild gestational hyperglycemia (MGH; 30 cases), gestational diabetes mellitus (GDM; 45 cases) and type-2 diabetes mellitus (DM2; 23 cases). Peripheral blood mononuclear cell (PBMC) isolation and/or leukocytes from whole maternal and umbilical cord blood were obtained from all groups at delivery. Nuclear and mitochondrial DNA damage were measured by gene-specific quantitative PCR, and the expression of mRNA and proteins involved in the base excision repair (BER) pathway were assessed by real-time qPCR and Western blot, respectively. Apoptosis was measured in vitro experiments by caspase 3/7 activity and ATP levels. Results: GDM and DM2 groups were characterized by an increase in oxidative stress biomarkers, an increase in nuclear and mitochondrial DNA damage, and decreased expression of mRNA (APE1, POLβ and FEN1) and proteins (hOGG1, APE1) involved in BER. The levels of hyperglycemia were associated with the in vitro apoptosis pathway. Blood levels of DNA damage in umbilical cord were similar among the groups. Newborns of diabetic mothers had increased expression of BER mRNA (APE1, POLβ and FEN1) and proteins (hOGG1, APE1, POLβ and FEN1). A diabetes-like environment was unable to induce apoptosis in the umbilical cord blood cells. Conclusions: Our data show relevant asymmetry between maternal and fetal blood cell susceptibility to DNA damage and apoptosis induction. Maternal cells seem to be more predisposed to changes in an adverse glucose environment. This may be due to differential ability in upregulating multiple genes involved in the activation of DNA repair response, especially the BER mechanism. However if this study shows a more effective adaptive response by the fetal organism, it also calls for further studies to determine the limit of this response that definitely changes the fate of a fetus under these conditions of cellular stress.