Miracle-dz/UniFAR-FTUs huggingface dataset:
Persisting Consequences of Stroke Measured by the Stroke Impact Scale

Background and Purpose— The purpose of this study was to compare disability and quality of life as measured by the Stroke Impact Scale (SIS) of stroke patients deemed recovered (Barthel Index ≥95) with 2 stroke-free populations of community-dwelling elderly. Methods— Eighty-one stroke patients who participated in the Kansas City Stroke Registry and achieved a Barthel Index of ≥95 at 3 months after stroke and 246 stroke-free subjects enrolled in the Community Elders Study were enrolled in this study. The Community Elders Study group was further divided into 2 groups, those recruited from the Department of Veterans Affairs Health System (VA) and a those from a local health maintenance organization (HMO). Stroke patients were administered the SIS ≈90 days after stroke, and the stroke-free community dwellers were administered a version of the SIS adapted for nonstroke subjects, the Health Impact Scale (HIS). A general linear model was used to examine differences in health outcomes measured by the SIS or HIS between the KCSR stroke patients and VA and HMO community-dwelling elders after controlling for medical comorbidities and demographics. Results— Kansas City Stroke Registry participants were significantly older than the community study groups (P =0.0052). Selected medical conditions were similar among the 3 study groups. Old age and a history of diabetes mellitus were more likely to be associated with more deficits and poor quality of life. In stroke patients deemed recovered, stroke still affected hand function, activities and independent activities of daily living, participation, and overall physical function compared with the stroke-free community dwellers in the HMO health system even after adjustment for age and diabetes status. Stroke-free community dwellers in the VA health system also had worse social participation than the stroke-free community dwellers in the HMO health system. Conclusions— Research and clinicians have consistently underestimated the impact of stroke with the Barthel Index. This has major implications for the design of therapeutic trial designs and adequate assessments of social and economic sequelae of stroke.
The Effects of Opinion Leaders and Change Messages on Organization Member Change Attitudes: A Field Experiment

Abstract : The extent to which three change introduction strategies (i.e., opinion leadership, edict, and change message) influenced readiness for change were tested at four locations as part of a quasi-field experiment with three groups receiving an enriched change message and one control group. Readiness was measured before and after change implementation where it was hypothesized that change readiness would be most improved within the groups that heard the most persuasive and rich change messages. These hypotheses were not supported and data indicated that the differing treatments were never received by the majority of the change recipients, rendering the results of the experiment questionable. Despite this, the findings provide a solid, theoretically grounded framework that can guide future projects.
Infection-Induced Retrotransposon-Derived Noncoding RNAs Enhance Herpesviral Gene Expression via the NF-κB Pathway

Short interspersed nuclear elements (SINEs) are highly abundant, RNA polymerase III-transcribed noncoding retrotransposons that are silenced in somatic cells but activated during certain stresses including viral infection. How these induced SINE RNAs impact the host-pathogen interaction is unknown. Here we reveal that during murine gammaherpesvirus 68 (MHV68) infection, rapidly induced SINE RNAs activate the antiviral NF-κB signaling pathway through both mitochondrial antiviral-signaling protein (MAVS)-dependent and independent mechanisms. However, SINE RNA-based signaling is hijacked by the virus to enhance viral gene expression and replication. B2 RNA expression stimulates IKKβ-dependent phosphorylation of the major viral lytic cycle transactivator protein RTA, thereby enhancing its activity and increasing progeny virion production. Collectively, these findings suggest that SINE RNAs participate in the innate pathogen response mechanism, but that herpesviruses have evolved to co-opt retrotransposon activation for viral benefit.
Pulmonary Arterial Hypertension: Classification and Therapy With a Focus on Prostaglandin Analogs

Pulmonary arterial hypertension, part of the larger spectrum of disorders causing pulmonary hypertension, is a complex and progressive disease of multiple etiologies that ultimately leads to vascular remodeling, right-sided heart failure, and death. Advances in treatment over the past 15 to 20 years have dramatically reduced the morbidity and mortality of the disease, but often have significant drawbacks. Of the more recently approved therapies, the prostaglandin analogs have been shown to have the greatest therapeutic benefit but are also the most difficult to administer, many being given as continuous intravenous infusions in the ambulatory setting. After a case presentation highlighting some of the challenges that accompany treatment with these agents, this article reviews the diagnosis and classification of pulmonary hypertension and pulmonary arterial hypertension and gives a brief overview of the various other pharmacologic agents used in its treatment. A more comprehensive review of the biochemistry of prostaglandins and the pharmacology and clinical use of this class of drugs follows. Recommended treatment guidelines are also discussed.
Fitting Spectral Decay with the k-Support Norm

The spectral $k$-support norm enjoys good estimation properties in low rank matrix learning problems, empirically outperforming the trace norm. Its unit ball is the convex hull of rank $k$ matrices with unit Frobenius norm. In this paper we generalize the norm to the spectral $(k,p)$-support norm, whose additional parameter $p$ can be used to tailor the norm to the decay of the spectrum of the underlying model. We characterize the unit ball and we explicitly compute the norm. We further provide a conditional gradient method to solve regularization problems with the norm, and we derive an efficient algorithm to compute the Euclidean projection on the unit ball in the case $p=\infty$. In numerical experiments, we show that allowing $p$ to vary significantly improves performance over the spectral $k$-support norm on various matrix completion benchmarks, and better captures the spectral decay of the underlying model.
Evaluation of the Maudsley Addiction Profile (MAP) for use with an American Substance Abuse Population

Multi-dimensional instruments in the addiction field developed in the United States as well as in other countries are limited. The Maudsley Addiction Profile (MAP), a brief, multidimensional instrument developed in the United Kingdom (UK), is designed to assess the treatment outcome of individuals with alcohol and/or drug (AOD) problems and associated issues.This measure consists of sixty items across the domains of substance use, health risk, physical/ psychological health and personal/social functioning. The MAP, which has been validated on British as well as on several European samples of substance abusers, has been suggested for further validation. The current study was designed to examine the psychometric features of the MAP on a sample of American AOD users. Subjects included 133 patients who had been admitted for treatment in an inpatient psychiatric hospital ; they had been identified with a recent substance abuse history. Seven interviewers were trained to criterion; 90 percent agreement with the investigator was achieved. The test-retest reliability of the MAP was good (average concordance of 0.96 across eight substances and 0.77 across health risk, health symptoms, and personal/social functioning). The interrater reliability among seven interviewers (one researcher and six clinicians) was also good (coefficients across eight substances were 0.95 and 0.78 across problem areas). The Pearson Correlation Coefficients of physical/psychological health symptoms between US and UK samples ranged between r = 0.97 and r = 0.98. Correlations among problem areas indicate several significant interactions between substance use and problem areas. Overall, the present study has shown that the MAP is a reliable outcome measure with several distinct advantages; it is an instrument which can be recommended for use in the US.
THE EFFECT OF INTOLERANCE OF UNCERTAINTY ON ATTENTION BIASES AS INDICATED BY PERFORMANCE ON THE EMOTIONAL STROOP AND DOT-PROBE TASK

Title of Dissertation THE EFFECT OF INTOLERANCE OF UNCERTAINTY ON ATTENTION BIASES AS INDICATED BY PERFORMANCE ON THE EMOTIONAL STROOP AND DOT-PROBE TASK Earta Norwood, Doctor of Philosophy, 2014 Directed By: Associate Professor Laura MacPherson Department of Psychology Anxiety disorders affect about 28.8% of the United States population at some time in their lifetime. Current theoretical models of anxiety disorders include cognitive constructs that are believed to play a crucial role in the etiology and maintenance of these disorders. Intolerance of uncertainty is one such cognitive construct, and it has been defined as a negative emotional, cognitive, or behavioral response to uncertain situations and events. Intolerance of uncertainty results in selective encoding and interpretation of information, such that people with high intolerance of uncertainty pay more attention to uncertain stimuli, go through greater elaborative encoding of uncertain information, have enhanced recollection of uncertain stimuli, and have a greater tendency to interpret such stimuli as threatening. Studies investigating processing biases in intolerance of uncertainty have used verbal-linguistic stimuli and have assessed biases during the interpretive and elaborative phase of information processing. The current study investigates intolerance of uncertainty as a moderator in the relationship between anxiety and information processing biases. Attention biases were assessed with the emotional Stroop task (using neutral words, threatening words, and words denoting uncertainty), and the dot-probe task (using photographs displaying faces with neutral or fearful expression). Contrary to our hypothesis, IU was not a moderator in the relationship between anxiety and automatic information processing biases. Additionally, we found no evidence of a relationship between IU and reaction times in the emotional Stroop and dotprobe task. Unexpectedly, the current study did not demonstrate a relationship between anxiety and automatic information processing biases. THE EFFECT OF INTOLERANCE OF UNCERTAINTY ON ATTENTION BIASES AS INDICATED BY PERFORMANCE ON THE EMOTIONAL STROOP AND DOTPROBE TASK
A Secure Base: Parent-Child Attachment and Healthy Human Development

* Caring for children * The origins of attachment theory * Psychoanalysis as art and science * Psychoanalysis as a natural science * Violence in the family * On knowing what you are not supposed to know and feeling what you are not supposed to feel * The role of attachment in personality development * Attachment, communication, and the therapeutic process * Developmental psychiatry comes of age
Analysis of heart-rate variability: a noninvasive predictor of death and poor outcome in patients with severe head injury.

BACKGROUND Analysis of heart-rate variability (HRV) is a promising new technique for noninvasive quantification of autonomic function. We measured HRV in patients with severe head injury to assess its potential as a monitoring tool. METHODS Analysis of HRV was prospectively done on all intensive care unit patients. Concurrent data on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) were collected. Registry data were reviewed to identify patients with severe head injury, defined as Head/Neck Abbreviated Injury Scale score > or = 4. Mortality, likelihood of discharge to home, ICP, and CPP were compared between patients with abnormal HRV and those without. RESULTS Low HRV was associated with increased mortality and decreased rate of discharge to home. Abnormal HRV was associated with episodes of increased ICP and decreased CPP. CONCLUSION Assessment of HRV is a noninvasive method that can be widely used. Abnormal HRV was associated with poor outcome and altered cerebral perfusion. Monitoring of HRV may improve outcome by allowing earlier detection and treatment of intracranial pathology.
Modelling the effect of incorporated halogenated pyrimidine on radiation-induced DNA strand breaks

Purpose : To estimate the enhancement of DNA strand breaks induced by low linear energy transfer (LET) radiation in the presence of halogenated pyrimidines and to examine complexity and clustering properties of damage that could provide a correlation between DNA damage and lethality. Materials and methods : Monte Carlo track structure methods were used to model and estimate the induction of strand breakage by X-ray photons with and without the incorporated Br/I deoxyuridine in cell-mimetic conditions. The increase of DNA strand break induction was modelled by taking into account the direct energy deposition and the reactions of radicals. The yield and spectrum of strand breaks were calculated at various degrees of Br/IdU incorporation. The excess strand breaks due to Br/IdU incorporation was assumed to be induced by highly reactive uracilyl radicals. Four mechanisms were considered for the production of uracilyl radicals classified into three groups, by hydrated electrons, by direct energy deposition, and by both hydrated electrons and direct energy depositions. In total, nine different models were considered to test the excess strand breaks by incorporated Br/IdU assuming different pathways. Results : Model calculations show the following: the yield of strand breaks is enhanced by both the e aq - reaction and the direct energy deposition on base moiety; there is a significant contribution to the enhancement of yield of strand breaks due to energy transfer about four bases along the DNA to Br/IdU and DNA strand break complexity increases with degree of Br/IdU incorporation. Enhancement ratios of 1.8 and 2.5 for 40% Br/IdU substitution were obtained for single- and double-strand breaks, respectively. Conclusions : The increase in the yield of strand breaks due to Br/IdU incorporation could be explained by the mechanism of uracilyl radical production by e aq - and direct energy deposition. The importance of energy transfer along the DNA is demonstrated. It is shown that the incorporation of Br/IdU causes a spectral shift towards a greater complexity of clustered DNA damage.
Pectinatus sottacetonis sp. nov., isolated from a commercial pickle spoilage tank.

A strictly anaerobic, Gram-stain-negative, non-spore-forming, motile bacterium, designated strain FSRU B0405(T), was isolated from a commercial pickle spoilage tank and characterized by biochemical, physiological and molecular biological methods. Analyses of the 16S rRNA gene sequence of strain FSRU B0405(T) showed affiliation to the class Negativicutes in the phylum Firmicutes, with the closest relatives being the type strains of Pectinatus haikarae (96 %) and Pectinatus brassicae (95 %). In maximum-likelihood and neighbour-joining phylogenetic trees, strain FSRU B0405(T) clustered definitively (in 100 % of bootstrapped trees) within the genus Pectinatus, but not specifically with any characterized species within this genus. Strain FSRU B0405(T) was a slightly curved rod, varying from 3 to 30 µm in length, motile with a distinctive X-wise movement, having flagella only on the concave side of the cell. The isolate produced acetate and propionate from fructose and glucose as major metabolites similar to type strains of species of the genus Pectinatus. The major fatty acids were C11 : 0, C13 : 0, C15 : 0, C13 : 0 3-OH, C17 : 1 and C18 : 1ω11t. Strain FSRU B0405(T) differed from the pickle wastewater strain, Pectinatus brassicae TY(T), due to its lack of susceptibility to vancomycin, acetoin production, growth temperature range, acid production from adonitol, erythritol, glycerol, inositol, lactose, maltose, mannose, ribose, salicin, sorbitol, trehalose and xylitol and lack of hydrolysis of milk. Strain FSRU B0405(T) could be differentiated from other species of the genus Pectinatus both phenotypically and genetically. The results indicate that strain FSRU B0405(T) represents a novel species of the genus Pectinatus, for which the name Pectinatus sottacetonis sp. nov. is proposed. The type strain is FSRU B0405(T) ( = ATCC BAA-2501(T) = VTT E-113163(T)). An emended description of the genus Pectinatus is also provided.
Multi-Label Zero-Shot Learning via Concept Embedding

Zero Shot Learning (ZSL) enables a learning model to classify instances of an unseen class during training. While most research in ZSL focuses on single-label classification, few studies have been done in multi-label ZSL, where an instance is associated with a set of labels simultaneously, due to the difficulty in modeling complex semantics conveyed by a set of labels. In this paper, we propose a novel approach to multi-label ZSL via concept embedding learned from collections of public users' annotations of multimedia. Thanks to concept embedding, multi-label ZSL can be done by efficiently mapping an instance input features onto the concept embedding space in a similar manner used in single-label ZSL. Moreover, our semantic learning model is capable of embedding an out-of-vocabulary label by inferring its meaning from its co-occurring labels. Thus, our approach allows both seen and unseen labels during the concept embedding learning to be used in the aforementioned instance mapping, which makes multi-label ZSL more flexible and suitable for real applications. Experimental results of multi-label ZSL on images and music tracks suggest that our approach outperforms a state-of-the-art multi-label ZSL model and can deal with a scenario involving out-of-vocabulary labels without re-training the semantics learning model.
The Perception of Texture on Folded Surfaces

Do judgments of texture similarity reflect surface texture or image texture? To find out, we had observers view a rectangular surface that was folded into three panels, much like a brochure. Each panel was textured with an oriented noise pattern and the observers' task was to determine which side panel matched the center panel in surface texture. Information about surface geometry was conveyed by binocular disparity and by the boundaries of the rectangular surface. We found that observers were often consistently wrong, selecting the texture that differed in the image and not on the surface. In sharp contrast, when observers judged the texture orientation on each panel individually, their judgments were accurate reflections of the surface texture. So even when observers can recover surface texture, their judgments of texture similarity may still be based on image texture.
Partial light field tomographic reconstruction from a fixed-camera focal stack

This paper describes a novel approach to partially reconstruct high-resolution 4D light fields from a stack of differently focused photographs taken with a fixed camera. First, a focus map is calculated from this stack using a simple approach combining gradient detection and region expansion with graph-cut. Then, this focus map is converted into a depth map thanks to the calibration of the camera. We proceed after this with the tomographic reconstruction of the epipolar images by back-projecting the focused regions of the scene only. We call it masked back-projection. The angles of back-projection are calculated from the depth map. Thanks to the high angular resolution we achieve by suitably exploiting the image content captured over a large interval of focus distances, we are able to render puzzling perspective shifts although the original photographs were taken from a single fixed camera at a fixed position.
Skill learning and task outcome prediction for manipulation

Learning complex motor skills for real world tasks is a hard problem in robotic manipulation that often requires painstaking manual tuning and design by a human expert. In this work, we present a Reinforcement Learning based approach to acquiring new motor skills from demonstration. Our approach allows the robot to learn fine manipulation skills and significantly improve its success rate and skill level starting from a possibly coarse demonstration. Our approach aims to incorporate task domain knowledge, where appropriate, by working in a space consistent with the constraints of a specific task. In addition, we also present an approach to using sensor feedback to learn a predictive model of the task outcome. This allows our system to learn the proprioceptive sensor feedback needed to monitor subsequent executions of the task online and abort execution in the event of predicted failure. We illustrate our approach using two example tasks executed with the PR2 dual-arm robot: a straight and accurate pool stroke and a box flipping task using two chopsticks as tools.
Avian blood parasites in an endangered columbid: Leucocytozoon marchouxi in the Mauritian Pink Pigeon Columba mayeri

SUMMARY There is increasing evidence that pathogens can play a significant role in species decline. This study of a complete free-living species reveals a cost of blood parasitism to an endangered host, the Pink Pigeon Columba mayeri, endemic to Mauritius. We investigated the prevalence and effect of infection of the blood parasite, Leucocytozoon marchouxi, in the free-living Pink Pigeon population. Overall, L. marchouxi infection prevalence detected was 18·3%. Juveniles were more likely to be infected than older birds and there was geographical variation in infection prevalence. Survival of birds infected with L. marchouxi was lower than that of uninfected birds to 90 days post-sampling. This study suggests that while common haematozoa are well tolerated in healthy adults, these parasites may have greater pathogenic potential in susceptible juveniles. The study is unusual given its completeness of species sampling (96%) within a short time-period, the accurate host age data, and its focus on blood parasites in a threatened bird species. Species for which long-term life-history data are available for every individual serve as valuable models for dissecting the contribution of particular pathogens to species decline.
Birth weight of US biracial (black-white) infants: regional differences.

OBJECTIVE The study examined the prevalence of low birth weight among biracial infants of black and white parents, by region of the United States. METHODS Using the national linked live birth-death infant file for 1991, low birth weight (<2,500 g) was examined among 50,980 biracial singleton infants according to parental race (black mother-white father vs. white mother-black father). RESULTS Nationally, the rate of low birth weight was 31% higher in the black mother-white father group (8.4%) than in the white mother-black father group (6.4%). The difference was smaller in the Northeast, reflecting a high rate (9.8%) for biracial infants of Puerto-Rican white mothers. The difference in the West was larger (75%), due to both a high rate in the black mother-white father group (9.1%) and a low rate for the white mother-black father group (5.2%), and persisted after controlling for parental education and a variety of maternal risk factors. CONCLUSIONS Further studies are needed to identify the maternal factors involved in the regional differences in the prevalence of low birth weight among biracial infants.