Miracle-dz/UniFAR-FTUs huggingface dataset:
Gs Protein-coupled Receptor Agonists Induce Transactivation of the Epidermal Growth Factor Receptor in T84 Cells

We have previously shown that Gq protein-coupled receptor (GqPCR) agonists stimulate epidermal growth factor receptor (EGFr) transactivation and activation of mitogen-activated protein kinases (MAPK) in colonic epithelial cells. This constitutes a mechanism by which Cl- secretory responses to GqPCR agonists are limited. In the present study we examined a possible role for the EGFr in regulating Cl- secretion stimulated by agonists that act through GsPCRs. All experiments were performed using monolayers of T84 colonic epithelial cells grown on permeable supports. Protein phosphorylation and protein-protein interactions were analyzed by immunoprecipitation and Western blotting. Cl- secretion was measured as changes in short-circuit current (ΔIsc) across voltage-clamped T84 cells. The GsPCR agonist, vasoactive intestinal polypeptide (VIP; 100 n○), rapidly stimulated EGFr phosphorylation in T84 cells. This effect was mimicked by a cell-permeant analog of cAMP, Bt2cAMP/AM (3 μ○), and was attenuated by the protein kinase A (PKA) inhibitor, H-89 (20 μ○). The EGFr inhibitor, tyrphostin AG1478 (1 μ○), inhibited both Bt2cAMP/AM-stimulated EGFr phosphorylation and Isc responses. VIP and Bt2cAMP/AM both stimulated ERK MAPK phosphorylation and recruitment of the p85 subunit of phosphatidylinositol 3-kinase (PI3K) to the EGFr in a tyrphostin AG1478-sensitive manner. The PI3K inhibitor, wortmannin (50 n○), but not the ERK inhibitor, PD 98059 (20 μ○), attenuated Bt2cAMP/AM-stimulated secretory responses. We conclude that GsPCR agonists rapidly transactivate the EGFr in T84 cells by a signaling pathway involving cAMP and PKA. Through a mechanism that likely involves PI3K, transactivation of the EGFr is required for the full expression of cAMP-dependent Cl- secretory responses.
Caractersticas sociodemogrficas y psicolgicas de la fobia social en adolescentes

Sociodemographic and psychological features of social phobia in the adolescence. The objective of this study is to analyze the demographic and clinical features of adolescent with social phobia based on the subtype. The sample included 120 adolescents diagnosed of Social Phobia (specific or generalized). The results show statistically significant differences between both subtypes of social phobia; so much in gender as on each measure that evaluate anxiety, social avoidance, fear of negative evaluation and other correlates. These data are consistent with results informed by several studies with adult population and provide useful information for the investigation and the clinical practice.
Conductivity Cusp in a Disordered Metal

A tendency toward a cusp at zero temperature in the electrical conductivity of Si crystals doped with P is observed. It is found that, within the metallic state, decreasing P concentration enhances the cusp and then rapidly changes its sign as a pseudogap opens. Such a cusp has been predicted for a disordered metal in which Coulomb interactions dominate the scattering.
Dynamic Analysis of the Lactococcus lactis Transcriptome in Cheeses Made from Milk Concentrated by Ultrafiltration Reveals Multiple Strategies of Adaptation to Stresses

ABSTRACT Lactococcus lactis is used extensively for the production of various cheeses. At every stage of cheese fabrication, L. lactis has to face several stress-generating conditions that result from its own modification of the environment as well as externally imposed conditions. We present here the first in situ global gene expression profile of L. lactis in cheeses made from milk concentrated by ultrafiltration (UF-cheeses), a key economical cheese model. The transcriptomic response of L. lactis was analyzed directly in a cheese matrix, starting from as early as 2 h and continuing for 7 days. The growth of L. lactis stopped after 24 h, but metabolic activity was maintained for 7 days. Conservation of its viability relied on an efficient proteolytic activity measured by an increasing, quantified number of free amino acids in the absence of cell lysis. Extensive downregulation of genes under CodY repression was found at day 7. L. lactis developed multiple strategies of adaptation to stressful modifications of the cheese matrix. In particular, expression of genes involved in acidic- and oxidative-stress responses was induced. L. lactis underwent unexpected carbon limitation characterized by an upregulation of genes involved in carbon starvation, principally due to the release of the CcpA control. We report for the first time that in spite of only moderately stressful conditions, lactococci phage is repressed under UF-cheese conditions.
Receivers for Diffusion-Based Molecular Communication: Exploiting Memory and Sampling Rate

In this paper, a diffusion-based molecular communication channel between two nano-machines is considered. The effect of the amount of memory on performance is characterized, and a simple memory-limited decoder is proposed; its performance is shown to be close to that of the best possible decoder (without any restrictions on the computational complexity or its functional form), using genie-aided upper bounds. This effect is adapted to the case of Molecular Concentration Shift Keying; it is shown that a four-bit memory achieves nearly the same performance as infinite memory for all of the examples considered. A general class of threshold decoders is considered and shown to be suboptimal for a Poisson channel with memory, unless the SNR is higher than a computed threshold. During each symbol duration (symbol period), the probability that a released molecule hits the receiver changes over the duration of the period; thus, we also consider a receiver that samples at a rate higher than the transmission rate (a multi-read system). A multi-read system improves performance. The associated decision rule for this system is shown to be a weighted sum of the samples during each symbol interval. The performance of the system is analyzed using the saddle point approximation. The best performance gains are achieved for an oversampling factor of three for the examples considered.
Cardioprotection of Electroacupuncture for Enhanced Recovery after Surgery on Patients Undergoing Heart Valve Replacement with Cardiopulmonary Bypass: A Randomized Control Clinical Trial

We attempted to investigate cardioprotection of electroacupuncture (EA) for enhanced recovery after surgery on patients undergoing heart valve replacement with cardiopulmonary bypass. Forty-four patients with acquired heart valve replacement were randomly allocated to the EA group or the control group. Patients in the EA group received EA stimulus at bilateral Neiguan (PC6), Ximen (PC4), Shenting (GV24), and Baihui (GV20) acupoints twenty minutes before anesthesia induction to the end of surgery. The primary end point was cardioprotection effect of electroacupuncture postoperatively and the secondary endpoints were quality of recovery and cognitive functioning postoperatively. The present study demonstrated that electroacupuncture reduced the occurrence of complications and played a role of cardioprotective effect on patients after heart valve replacement surgery with cardiopulmonary bypass, and it benefits patients more comfortable and contributes to recovery after surgery. This trial is registered with ChiCTR-IOC-16009123.
When Asking “Why” Does Not Hurt Distinguishing Rumination From Reflective Processing of Negative Emotions

Two experiments examined the psychological operations that enable individuals to process negative emotions and experiences without increasing negative affect. In Study 1, type of self-perspective (self-immersed vs. self-distanced) and type of emotional focus (what vs. why) were experimentally manipulated following the recall of an anger-eliciting interpersonal experience. A why focus on emotions from a self-distanced perspective (distanced-why strategy) was expected to enable “cool,” reflective processing of emotions, in which individuals can focus on their experience without reactivating excessive “hot” negative affect. Findings were consistent with this hypothesis. Study 2 replicated these findings and furthermore demonstrated that (a) the degree to which individuals construe their recalled experience in abstract versus concrete terms mediates the effect of the distanced-why strategy and (b) the status of the recalled experience (resolved vs. unresolved) does not moderate the effectiveness of the distanced-why strategy. These findings help disentangle the mechanisms that may allow adaptive working through from those that lead to rumination.
Christian spirituality and marital health: A phenomenological study of long-term marriages

CHRISTIAN SPIRITUALITY AND MARITAL HEALTH: A PHENOMENOLOGICAL STUDY OF LONG-TERM MARRIAGES David Caldwell Dixon Center for Counseling and Family Studies Liberty University, Lynchburg, Virginia Doctor of Philosophy in Counseling This is a phenomenological study examining the shared experiences expressed by 10 couples who have been married one time for more than thirty years and have been described as practicing Christian spirituality within their marital relationship. The data was collected by one source, the researcher, as the couple‟s participated in a joint interview. Two major Christian spirituality themes emerged from the couple‟s interviews. The first major Christian spirituality theme was being and doing. The being and doing theme interplayed throughout the interview with the emerging process factors of affectionate expression, bonding, and commitment. The second major Christian spirituality theme which emerged was marriage and growing. As couples told their stories a Marital Growth Model emerged from the study which included the outcome variable of hope which existed within the vernacular of many of the participants interviewed. This study has implications for enrichment programs for churches as well as aiding premarital and young couples in understanding the developmental processes of marriage from a Christian spirituality perspective. Suggestions for future study include qualitative research to other faith religions, mixed populations, and cultures.
Approximate Sentence Retrieval for Scalable and Efficient Example-Based Machine Translation

Approximate sentence matching (ASM) is an important technique for tasks in machine translation (MT) such as example-based MT (EBMT) which influences the translation time and the quality of translation output. We investigate different approaches to find similar sentences in an example base and evaluate their efficiency (runtime), effectiveness, and the resulting quality of translation output. A comparison of approaches demonstrates that i) a sequential computation of the edit distance between an input sentence and all sentences in the example base is not feasible, even when efficient algorithms to compute the edit distance are employed; ii) in-memory data structures such as tries and ternary search trees are more efficient in terms of runtime, but are not scalable for large example bases; iii) standard IR models which only cover material similarity (e.g. term overlap), do not perform well in finding the approximate matches, due to their lack of handling word order and word positions. We propose a new retrieval model derived from language modelling (LM), named LM-ASM, to include positional and ordinal similarities in the matching process, in addition to material similarity. Our IR based retrieval experiments involve reranking the top-ranked documents based on their true edit distance score. Experimental results show that i) IR based approaches result in about 100 times faster translation; ii) LM-ASM approximates edit distance better than standard LM by about 10%; and iii) surprisingly, LM-ASM even improves MT quality by 1:52% in comparison to sequential edit distance computation.
The Flatness Theorem for Nonsymmetric Convex Bodies via the Local Theory of Banach Spaces

Let L be a lattice in Rn and K a convex body disjoint from L. The classical Flatness Theorem asserts that then w(K, L), the L-width of K, does not exceed some bound, depending only on the dimension n; this fact was later found relevant to questions in integer programming. Kannan and Lovasz (1988) showed that under the above assumptions w(K, L) ≤ Cn2, where C is a universal constant. Banaszczyk (1996) proved that w(K, L) ≤ Cn(1 + log n) if K has a centre of symmetry. In the present paper we show that w(K, L) ≤ Cn3/2 for an arbitrary K. It is conjectured that the exponent 3/2 may be replaced by 1, perhaps at the cost of a logarithmic factor; we prove that for some naturally arising classes of bodies.
Self-Processing and the Default Mode Network: Interactions with the Mirror Neuron System

Recent evidence for the fractionation of the default mode network (DMN) into functionally distinguishable subdivisions with unique patterns of connectivity calls for a reconceptualization of the relationship between this network and self-referential processing. Advances in resting-state functional connectivity analyses are beginning to reveal increasingly complex patterns of organization within the key nodes of the DMN – medial prefrontal cortex and posterior cingulate cortex – as well as between these nodes and other brain systems. Here we review recent examinations of the relationships between the DMN and various aspects of self-relevant and social-cognitive processing in light of emerging evidence for heterogeneity within this network. Drawing from a rapidly evolving social-cognitive neuroscience literature, we propose that embodied simulation and mentalizing are processes which allow us to gain insight into another’s physical and mental state by providing privileged access to our own physical and mental states. Embodiment implies that the same neural systems are engaged for self- and other-understanding through a simulation mechanism, while mentalizing refers to the use of high-level conceptual information to make inferences about the mental states of self and others. These mechanisms work together to provide a coherent representation of the self and by extension, of others. Nodes of the DMN selectively interact with brain systems for embodiment and mentalizing, including the mirror neuron system, to produce appropriate mappings in the service of social-cognitive demands.
Differences in Stream Water Nitrate Concentrations between a Nitrogen-Saturated Upland Forest and a Downstream Mixed Land Use River Basin

Nitrogen (N) saturation of upland forests has been assumed to be a substantial N source downstream. However, removal processes of N, including assimilation and denitrification in the downstream area, have not been clarified. To evaluate the N removal processes, nitrate (NO3−) and organic N concentrations, as well as nitrogen isotope ratio (δ15N) and oxygen isotope ratio (δ18O) of NO3− were measured along three rivers of Tatara River Basin, Japan where upland forests have already been N-saturated. Geographic information system (GIS) based topographical analysis was also conducted to evaluate the land use as urban area in relation to topography. In two of the three rivers, NO3− concentrations did not increase from upstream to downstream, despite the potential non-point N sources of urban areas. In another river, NO3− concentrations rather decreased. The values of δ15N and δ18O of NO3− and organic N concentrations suggested the presence of denitrification and assimilation over N pollutants in the river whose watersheds have a lower percentage of urban area. The lower percentage of urban area could be explained by the lower topographic index. This study concluded that the NO3− leaching from upland N-saturated forests was substantially assimilated or denitrified in the downstream area.
Trading Costs and Informational Efficiency

Abstract This paper studies the effect of trading costs on information diffusion and information acquisition in financial markets. For a given precision of investors' private information, an irrelevance result emerges when investors are ex-ante identical: the level of trading costs does not affect price informativeness or price volatility. This result holds independently of whether investors behave competitively or strategically and applies to both static and dynamic economies. When investors are ex-ante heterogeneous, trading costs affect price informativeness if and only if investors who disproportionately trade on information are more elastic than investors who mostly trade due to hedging. Trading costs always reduce information acquisition, even when price informativeness remains unchanged for a given amount of information. Our results matter to understand a) the consequences of cheaper financial trading and b) the effects of transaction taxes.
Clinical Update in Aspects of the Management of Autoimmune Thyroid Diseases

Aspects of autoimmune thyroid disease updated in this review include: immunoglobulin G4 (IgG4)-related thyroid disease (Riedel's thyroiditis, fibrosing variant of Hashimoto's thyroiditis, IgG4-related Hashimoto's thyroiditis, and Graves' disease with elevated IgG4 levels); recent epidemiological studies from China and Denmark indicating that excess iodine increases the incidence of Hashimoto's thyroiditis and hypothyroidism; immunomodulatory agents (ipilimumab, pembrolizumab, nivolumab) activate immune response by inhibiting T-cell surface receptors which down-regulate immune response, i.e., cytotoxic T-lymphocyte antigen 4 and programmed cell death protein 1 pathways; alemtuzumab is a humanised monoclonal antibody to CD52 which causes immune depletion and thyroid autoimmune disease especially Graves' hyperthyroidism; small molecule ligand (SML) agonists which activate receptors, SML neutral antagonists, which inhibit receptor activation by agonists, and SML inverse agonists which inhibit receptor activation by agonists and inhibit constitutive agonist independent signaling have been identified. SML antagonism of thyroid-stimulating hormone-receptor stimulatory antibody could treat Graves' hyperthyroidism and Graves' ophthalmopathy; and thyroxine treatment of subclinical hypothyroidism can produce iatrogenic subclinical hyperthyroidism with the risk of atrial fibrillation and osteoporosis. The increased risk of harm from subclinical hyperthyroidism may be stronger than the potential benefit from treatment of subclinical hypothyroidism.
Spatio‐temporal organization of DNA replication in murine embryonic stem, primary, and immortalized cells

The extent to which chromosomal domains are reorganized within the nucleus during differentiation is central to our understanding of how cells become committed to specific developmental lineages. Spatio‐temporal patterns of DNA replication are a reflection of this organization. Here, we demonstrate that the temporal order and relative duration of these replication patterns during S‐phase are similar in murine pluripotent embryonic stem (ES) cells, primary adult myoblasts, and an immortalized fibroblast line. The observed patterns were independent of fixation and denaturation techniques. Importantly, the same patterns were detected when fluorescent nucleotides were introduced into living cells, demonstrating their physiological relevance. These data suggest that heritable gene silencing during commitment to specific cell lineages is not mediated by global changes in the sub‐nuclear organization and replication timing of chromosome domains. © 2004 Wiley‐Liss, Inc.
Can a Changing α Explain the Supernovae Results?

We show that the supernovae results, which imply that there is evidence for an accelerating universe, may be closely related to the recent discovery of redshift dependence in the fine-structure constant α. The link is a class of varying speed-of-light (VSL) theories that contain cosmological solutions that are similar to quintessence. During the radiation-dominated epoch, the cosmological constant Λ is prevented from dominating the universe by the usual VSL mechanism. In the matter-dominated epoch, the varying-c effects switch off, allowing Λ to eventually surface and lead to an accelerating universe. By the time this happens, the residual variations in c imply a changing α at a rate that is in agreement with observations.
From the actual to the real : left wing documentary film in Australia

This thesis constructs and develops a critique of the tradition of left wing documentary film in Australia. The critique is from the perspective of the Critical Realist paradigm developed by Roy Bhaskar and others. The thesis is both an attempt to critique a tradition and to provide a new basis for documentary theory and criticism. On the theoretical level the thesis engages the work of the leading documentary film theorists including Noel Carroll, Bill Nichols, Paula Rabinowitz, Michael Renov and Trinh T. Minh-ha. These theorists take up positions, which range from New Realist to Poststructuralist. It is the contention of this thesis that, because they lack a notion of a stratified ontology, they are unable to sustain either a critique of or a coherent account of documentary practice. The definition of left wing that underpins the selection of the films is a narrow one, namely, coming from or influenced by the Marxist tradtion. The criticism of the films begins with Joris Ivens Indonesia Calling (1946) and concludes with Tom Zubrycki's Billal (l996).
Comparison of Integrated and Isolated Training on Performance Measures and Neuromuscular Control

Abstract DiStefano, LJ, DiStefano, MJ, Frank, BS, Clark, MA, and Padua, DA. Comparison of integrated and isolated training on performance measures and neuromuscular control. J Strength Cond Res 27(4): 1083–1090, 2013—Traditional weight training programs use an exercise prescription strategy that emphasizes improving muscle strength through resistance exercises. Other factors, such as stability, endurance, movement quality, power, flexibility, speed, and agility are also essential elements to improving overall functional performance. Therefore, exercises that incorporate these additional elements may be beneficial additions to traditional resistance training programs. The purpose of the study was to compare the effects of an isolated resistance training program (ISO) and an integrated training program (INT) on movement quality, vertical jump height, agility, muscle strength and endurance, and flexibility. The ISO program consisted of primarily upper and lower extremity progressive resistance exercises. The INT program involved progressive resistance exercises, and core stability, power, and agility exercises. Thirty subjects were cluster randomized to either the ISO (n = 15) or INT (n = 15) training program. Each training group performed their respective programs 2 times per week for 8 weeks. The subjects were assessed before (pretest) and after (posttest) the intervention period using the following assessments: a jump-landing task graded using the Landing Error Scoring System (LESS), vertical jump height, T-test time, push-up and sit-up performance, and the sit-and-reach test. The INT group performed better on the LESS test (pretest: 3.90 ± 1.02, posttest: 3.03 ± 1.02; p = 0.02), faster on the T-test (pretest: 10.35 ± 1.20 seconds, posttest: 9.58 ± 1.02 seconds; p = 0.01), and completed more sit-ups (pretest: 40.20 ± 15.01, posttest: 46.73 ± 14.03; p = 0.045) and push-ups (pretest: 40.67 ± 13.85, posttest: 48.93 ± 15.17; p = 0.05) at posttest compared with pretest, and compared with the ISO group at posttest. Both groups performed more push-ups (p = 0.002), jumped higher (p < 0.001), and reached further (p = 0.008) at posttest compared with that at pretest. Performance enhancement programs should use an integrated approach to exercise selection to optimize performance and movement technique benefits.