Miracle-dz/UniFAR-FTUs huggingface dataset:
Religious Coping Among Those With Persistent Mental Illness

Although religious coping has gained acceptance in some spheres of mental health treatment, it has yet to be integrated into the treatment of those suffering from persistent mental illness. In this study, 379 individuals with persistent mental illness who attended 1 of 13 Los Angeles County Mental Health facilities completed a survey consisting of a demographic questionnaire and an adapted version of the Religious Coping Index. More than 81% of the participants reported using religious beliefs or activities to cope, 65% perceived religion as effective, and the majority devoted up to 50% of their total coping time to religion. Participants with more severe symptomatology were more likely to engage in specific religious coping strategies than those with less severe symptoms. These findings suggest that religion may serve as an important coping mechanism for those with persistent mental illness and that such coping could be appropriately incorporated into the treatment and research afforded by mental health professionals.
Does the disturbance hypothesis explain the biomass increase in basin‐wide Amazon forest plot data?

Positive aboveground biomass trends have been reported from old‐growth forests across the Amazon basin and hypothesized to reflect a large‐scale response to exterior forcing. The result could, however, be an artefact due to a sampling bias induced by the nature of forest growth dynamics. Here, we characterize statistically the disturbance process in Amazon old‐growth forests as recorded in 135 forest plots of the RAINFOR network up to 2006, and other independent research programmes, and explore the consequences of sampling artefacts using a data‐based stochastic simulator. Over the observed range of annual aboveground biomass losses, standard statistical tests show that the distribution of biomass losses through mortality follow an exponential or near‐identical Weibull probability distribution and not a power law as assumed by others. The simulator was parameterized using both an exponential disturbance probability distribution as well as a mixed exponential–power law distribution to account for potential large‐scale blowdown events. In both cases, sampling biases turn out to be too small to explain the gains detected by the extended RAINFOR plot network. This result lends further support to the notion that currently observed biomass gains for intact forests across the Amazon are actually occurring over large scales at the current time, presumably as a response to climate change.
Children's Perceptions of Their Sibling Relationships During Parental Separation and Divorce

Abstract The central aim of this paper is to explore whether parental separation and divorce influence children's experiences of the sibling relationship. In addressing this research aim, the paper draws on the first wave data from a longitudinal study of sibling relationships and adolescent adjustment to parental divorce. Participants include the adolescent children and their parents from 137 divorcing families, and from a comparison sample of 165 intact families. Adolescents reported on the quality of their relationship with their siblings by filling in questionnaires, and by participating in a semi-structured interview. Adolescent children from separating and divorced families were significantly more likely than children from continuously married (or intact) families to have affect-intense sibling relationships-that is, relationships characterised by high levels of both hostility and warmth. Adolescents related these aspects of the sibling relationship to their experiences of the separation and divorce of their parents, particularly the degree of conflict between parents and the absence of a father in the children's day-to-day lives. Results are discussed in terms of the role of the sibling relationship in supporting children through parental separation and divorce.
Nitrous Oxide and Carbon Dioxide Have No Effect on the Blood-Gas Solubilities of Sevoflurane and Isoflurane

Nitrous oxide (N2 O) has been shown to decrease the solubility (lambda (B):G) of volatile anesthetics in human blood and, consequently, affect their rate of uptake. If this is true, then carbon dioxide (CO2) may also have an effect, which is important because methods that measure the tension of volatile anesthetics in blood washout CO2 in the process. Blood samples were obtained from fasted, healthy volunteers and patients undergoing major surgery. Each sample was divided into two aliquots: one was equilibrated at 37[degree sign]C in a closed glass tonometer with a mixture of isoflurane 1% and sevoflurane 2% in a test gas mixture of either 50:50 N2 O/O2 or 5:95 CO2/O2; the other aliquot was equilibrated with isoflurane and sevoflurane in O2 alone as a control. Using a two-stage headspace technique using gas chromatography, we measured the lambdaB:G of isoflurane and sevoflurane in the presence and absence of the test gas in each subject. There was no significant difference between the lambdaB:G of sevoflurane and isoflurane obtained from the N2 O group and their controls or between the CO2 group and their controls. We conclude that neither N2 O nor CO2 has an effect on the lambdaB:G of sevoflurane or isoflurane in the concentrations tested. Implications: The blood solubilities of sevoflurane and isoflurane were measured with and without nitrous oxide and carbon dioxide. No differences were found. Nitrous oxide does not affect the kinetics of other anesthetics by altering their solubility. Carbon dioxide tensions need not be controlled when measuring anesthetic tensions in blood. (Anesth Analg 1998;87:1412-5)
Efficacy of RPMI 1640 and M 199 media in the isolation of Leishmania from cutaneous lesions

The in-vitro isolation of Leishmania parasites is often useful in the diagnosis of leishmaniasis and in the identification of the parasites to at least species level, using either molecular-biological methods or isoenzyme characterisation. At least in the isolation of the causative agent of human cutaneous leishmaniasis in Sri Lanka, L. donovani zymodeme MON-37 (Karunaweera et al., 2003), monophasic microculture using RPMI 1640 medium supplemented with 20% (v/v) heatinactivated foetal calf serum (FCS) has been found to be more sensitive than the more traditional methods employing biphasic media such as Novy, McNeal and Nicolle (NNN) medium or Evan’s modified Tobie’s medium (Ihalamulla et al., 2005). The aim of the present study was to see if microculture in M 199 medium — the medium commonly used for the mass cultivation of Leishmania in Sri Lanka — performed even better than microculture with RPMI 1640 in the initial isolation of L. donovani zymodeme MON-37.
New Technique for Fault Detection in Quantum Cellular Automata

Quantum cellular automata (QCA) circuits, the new generation nanotechnology with wide attention in recent years. In this we are proposing a framework based on QCA for finding out the stuck-at fault of a circuit. The existing technologies and methods are not guaranteed to detect the stuck-at faults. This work is motivated by the fact that the stuck-at fault test set of a circuit is not guaranteed to detect all defects that can occur in its QCA implementation.
Advocacy and Empowerment in Parent Consultation: Implications for Theory and Practice

In this article, the authors expand the view of parental consultation to include advocacy and empowerment as important contextual considerations. A brief review of existing approaches to parent consultation is provided. Selected advances in multicultural parent consultation are also presented. An advocacy-and empowerment-focused perspective is offered that describes the power of consultation with parents from marginalized backgrounds. A case vignette is provided to illustrate the implications for practice.
Language practice as games: Implications for sociology of translation in development contexts in Africa

Abstract Drawing from Game Theory, the article conceptualises language practice as games, that is convergences of strategic interaction, and explores the implications of such a conceptualisation for sociology of translation (la sociologie de la traduction – Michel Callon) in development contexts in Africa. The discussion posits that a conceptualisation of language practice as games further enriches research into the sociology of translation in development contexts in Africa in several ways. First, it enables the delineation and specification of language permutations that characterise the hybridity of networks, which in turn defines sociology of translation in development contexts, which are defined and populated by a multiplicity of entities. Second, it allows for a conceptualisation, interrogation and exploration of optimal strategies for network establishment, sustenance and reproduction in the course of development processes, and of the role of language in these processes. Third, it locates sociology of translation at the core of the development process by highlighting its strategic value in the production of socially acceptable language goods and services.
Logistics and Supply Chain Management: An Area with a Strategic Service Perspective

Logistics and supply chain management is an area that evolved deeply in the past years, integrating developments of other areas of knowledge, both entrepreneurial and general. In this paper, a perspective of the evolution of logistics and supply chain management is somehow designed. Traditionally, one may find logistics and supply chain management in friction with marketing and claiming for its own space. Nowadays, it seems difficult to see internal (logistics) versus external (marketing) wars and different orientations between marketing and logistics because they are both service and relations oriented. Simple transactions have been substituted, long time ago, for sustainable relations in the area of logistics and supply chain management. Finally, a more service oriented logic has been the footprint of logistics and supply chain management in current days and not, as pretended for some current rows of investigation, a simple transaction approach under a goods dominant logic. Logistics and supply chain management is nowadays in parallel with an S-D logic (service dominant logic) because it is an area where relations matter, where sustainable links between networks of companies are crucial and where service is key in order to accommodate the contemporary thoughts and practices in the area. The main purpose of the paper is to stress the point that logistics and supply chain management is an area of service and value creation (or co-creation) and not a simple area of goods exchange and simple transactions.
Loss of XIAP sensitizes rosiglitazone‐induced growth inhibition of colon cancer in vivo

Ligands for peroxisome proliferator‐activated receptor gamma (PPARγ) possess anticancer properties. However, the efficacy of PPARγ ligands varies in different cancers. In colon cancer, the role of PPARγ and its ligands is controversial. We recently showed that downregulation of X‐linked inhibitor of apoptosis protein (XIAP) could sensitize colon cancer cells to troglitazone, and 15‐deoxy‐D12,14‐prostaglandin J2 (15‐PGJ2) induced cell killing. In our study, we aimed to examine whether rosiglitazone, another more clinically relevant PPARγ ligand, has any synergistic anticancer effect with XIAP downregulation in colon cancer. Human colon cancer cell lines HCT116‐XIAP+/+ cells and HCT116‐XIAP−/− cells were treated with various concentrations of rosiglitazone. The effects of rosiglitazone on cell proliferation, apoptosis and growth of xenograft colon cancers were studied. Rosiglitazone barely suppressed the growth and only very weakly induced apoptosis in HCT116 cells in vitro. Loss of XIAP did not sensitize HCT116 cells to rosiglitazone‐induced growth inhibition or apoptosis. In vivo studies revealed that rosiglitazone strongly suppressed the growth of xenograft colon cancer, especially tumors derived from HCT116‐XIAP−/− cells. The rosiglitazone‐treated tumor had reduced expression of ki‐67 and lowered mitotic rate. Downregulation of XIAP was associated with an impaired activation of PPARγ by its ligand. Rosiglitazone induced marked upregulation of PTEN in HCT116‐XIAP−/− cells, as well as in xenograft tumors derived from HCT116‐XIAP−/− cells. We concluded that rosiglitazone significantly suppresses the growth of xenograft colon cancer, and downregulation of XIAP sensitizes the xenograft tumors to rosiglitazone‐induced tumor suppression in vivo via upregulation of PTEN. © 2008 Wiley‐Liss, Inc.
Transitioning Meanings? Family Members' Communicative Struggles Surrounding Transgender Identity

With the growing number of transgender individuals coming forward, it is important that scholars turn attention to the experiences of these identities and transitions for transgender persons and their families. The present study used a relational dialectics approach to analyze communication of family members (both transgender and not) about transgender identity and transition via online postings to discussion forums. Results showed three sites of struggle present for family members and partners, as well as transgender persons: Presence vs. Absence, Sameness vs. Difference, and Self vs. Other. The presence-absence and sameness-difference struggles centered on family members' and partners' experiences with grief surrounding the transgender person's transition process and the self-other struggle was centered on the issue of support. The tensions illustrated in the data, and especially the experience of loss, indicate that family members and spouses/partners of transgender persons may struggle with meaning-making surrounding a transition in sex and/or gender identity. This struggle over meaning suggests that sex and gender are fundamental to the ways in which we conceptualize and interact with relational partners and that when they change, we may conceptualize and relate to partners/relatives differently.
Characterization of a calcium-dependent calmodulin-binding domain in the 135-kD human protein 4.1 isoform.

The putative calmodulin binding domain of non-erythroid protein 4.1, previously suggested by Kelly et al. [Kelly, G. M. , Zelus, B. D. & Moon, R. T. (1991) J. Biol. Chem. 266, 12469-12473] has been synthesized, and its binding to calmodulin has been studied by fluorescence spectroscopy. For this purpose, the peptide has been N-terminally dansylated. The 4.1 peptide Dns-Abu-S76RGLSRLFSSFLKRPKS92, binds calmodulin in a calcium-dependent way with high affinity (Kd = 23 +/- 6 nM). The peptide inhibits bovine-heart phosphodiesterase with an IC50 of 50 nM. Since the sequence of the peptide shows two putative consensus sites of phosphorylation by cAMP-dependent protein kinase or Ca2+-calmodulin protein-kinase II, the interaction of the two mono-phosphorylated peptides (P4.1 Ser(80-P) and P4.1 Ser(84-P)) and the di-phosphorylated peptide (P4.1 Ser(80-P)/Ser(84-P)) with calmodulin has been investigated. A decrease of affinity by a factor 1.5-8 has been observed for the phosphorylated peptides. CD measurements have shown an increase of the content of alpha helices in the peptides when bound to calmodulin.
Video surveillance for elderly monitoring and safety

In this paper we propose a novel method to detect and record various posture-based and movement-based events of interest in a typical elderly monitoring application in a home surveillance scenario. Posture-based events include standing, sitting, bending/squatting, side lying and lying toward the camera. While movement-based events include running, jumping, active and inactive events. For posture classification, we use the projection histograms of foreground as the main feature vector. k-Nearest Neighbor (k-NN) algorithm and evidence accumulation technique is proposed to infer human postures. With this technique, we have achieved a robust posture recognition rate of above 90% and a stable classifier's output. Furthermore, we use the speed of fall to differentiate real fall incident and an event where the person is simply lying without falling. On the other hand, time series signal change detection techniques are used for movement classification task. The accuracy obtained for movement-based events detection is above 90%.
Nebivolol improves coronary flow reserve in patients with idiopathic dilated cardiomyopathy

Background: Impaired coronary flow reserve (CFR) is a significant predictor of poor prognosis in patients with idiopathic dilated cardiomyopathy (IDC). Nebivolol reduces mortality and morbidity in patients with heart failure and left ventricular dysfunction, including cases caused by IDC. Objective: To assess the effects of nebivolol on CFR in patients with IDC. Methods: CFR was measured in 21 clinically stable patients with IDC (mean (SD) ejection fraction 35.7 (6.2)) at baseline and after 1 month of treatment with nebivolol once daily. A control group of apparently healthy subjects who were matched for age and sex was used for comparison. Resting and hyperaemic coronary flows were measured using transthoracic second-harmonic Doppler echocardiography. None of the subjects had any systemic disease. Results: After 1 month of treatment, heart rate was reduced significantly (p<0.001). The blood pressure was decreased significantly (p<0.001). The left ventricular end-diastolic diameter and stroke volume were not changed significantly, but end-systolic diameter was decreased significantly (p<0.05). Resting rate–pressure product was lower after treatment with nebivolol, but dipyridamole-induced change was not influenced by the treatment. Nebivolol treatment reduced significantly coronary velocities at rest (p<0.02) and also caused a significant increase in coronary velocities after dipyridamole (p<0.02), leading to a greater CFR (2.02 (0.35) vs 2.61 (0.43), p<0.001). Nebivolol induced an absolute increase of 6% in the CFR in 17 of 21 patients (80.9%). Conclusions: In patients with IDC, 1 month of treatment with nebivolol induces a marked increase in CFR.
MEKK1 Is Required for flg22-Induced MPK4 Activation in Arabidopsis Plants1[C][W]

The Arabidopsis (Arabidopsis thaliana) gene MEKK1 encodes a mitogen-activated protein kinase kinase kinase that has been implicated in the activation of the map kinases MPK3 and MPK6 in response to the flagellin elicitor peptide flg22. In this study, analysis of plants carrying T-DNA knockout alleles indicated that MEKK1 is required for flg22-induced activation of MPK4 but not MPK3 or MPK6. Experiments performed using a kinase-impaired version of MEKK1 (K361M) showed that the kinase activity of MEKK1 may not be required for flg22-induced MPK4 activation or for other macroscopic FLS2-mediated responses. MEKK1 may play a structural role in signaling, independent of its protein kinase activity. mekk1 knockout mutants display a severe dwarf phenotype, constitutive callose deposition, and constitutive expression of pathogen response genes. This dwarf phenotype was largely rescued by introduction into mekk1 knockout plants of either the MEKK1 (K361M) construct or a nahG transgene that degrades salicylic acid. When treated with pathogenic bacteria, the K361M plants were slightly more susceptible to an avirulent strain of Pseudomonas syringae and showed a delayed hypersensitive response, suggesting a role for MEKK1 kinase activity in this aspect of plant disease resistance. Our results indicate that MEKK1 acts upstream of MPK4 as a negative regulator of pathogen response pathways, a function that may not require MEKK1's full kinase activity.
Colonoscopy and computerized tomography scan are not sufficient to localize right‐sided colonic lesions accurately

Aim Accurate preoperative localization of colonic lesions is critical especially in laparoscopic colectomy where tactile localization is absent particularly in screen‐detected tumours. The study aimed to evaluate the accuracy of colonoscopy and double‐contrast computerized tomography (CT) scan to localize lesions treated by right hemicolectomy.
Ranking music data by relevance and importance

Due to the rapidly increasing availability of audio files on the Web, it is relevant to augment search engines with advanced audio search functionality. In this context, the ranking of the retrieved music is an important issue. This paper proposes a music ranking method capable of flexibly fusing the music based on its relevance and importance. The fusion is controlled by a single parameter, which can be intuitively tuned by the user. The notion of authoritative music among relevant music is introduced, and social media mined from the Web is used in an innovative manner to determine both the relevance and importance of music. The proposed method may support users with diverse needs when searching for music.
miR-215 promotes malignant progression of gastric cancer by targeting RUNX1

Objective miR-215 was reported to be downregulated and functioned as a tumor suppressor in several cancers. In contrast, miR-215 was preferentially upregulated in gastric cancer (GC) according to our data. Thus, we studied the potential biological function of miR-215 in GC. Methods miR-215 expression was measured in 77 paired GC tissues and adjacent non-tumor tissues. Biological functions of miR-215 were analyzed using cell viability, colony formation, migration, invasion, cell cycle, apoptosis and luciferase assays as well as via tumorigenicity and metastasis analysis. Results miR-215 was significantly upregulated in 7 GC cell lines and 77 GC tissues compared to adjacent non-tumor tissues (P < 0.05), and miR-215 expression was greater in advanced GC (stage III/IV; P < 0.05). Ectopic expression of miR-215 in GES-1 and HGC-27 cells (low miR-215 expression) promoted cell growth, migration, invasion, and metastasis, and these were reversed in NCI-N87 cells (high miR-215 expression) after miR-215 downregulation. Potential target genes of miR-215 were predicted and RUNX1, a transcription factor and a tumor suppressor, was confirmed to be potential target according to luciferase studies. RUNX1 was downregulated in GC tissues compared to adjacent non-tumor tissues (P < 0.05), and RUNX1 reversed partial function of miR-215 in vitro. Conclusion miR-215 promotes malignant progression of GC by targeting RUNX1, and RUNX1 can partially reverse miR-215 effects.
The changing role of the subject librarian, with a particular focus on UK developments, examined through a review of the literature

Using a literature review this paper examines the changing role of the subject librarian within UK higher education institutions. Identifies models of subject librarianship in different countries for comparison with the UK role. Defines the role of subject librarian before the Follett Report and highlights the impact the report has had on the role. Considers how the role has developed since the Follett Report from the perspective of library managers. The relationship between subject librarians and the academic departments they serve, and the subject knowledge required to execute this function, have always been areas of concern. Since the Follett Report the increasing involvement of subject librarians in teaching students has added a new dimension to the relationship with academic departments. The liaison the subject librarian provides between the library and academic departments is an enduring facet of the role and helps to explain why it has persisted.