Miracle-dz/UniFAR-FTUs huggingface dataset:
Antiviral Lectins from Red and Blue-Green Algae Show Potent In Vitro and In Vivo Activity against Hepatitis C Virus

Hepatitis C virus (HCV) infection is a significant public health problem with over 170,000,000 chronic carriers and infection rates increasing worldwide. Chronic HCV infection is one of the leading causes of hepatocellular carcinoma which was estimated to result in ∼10,000 deaths in the United States in the year 2011. Current treatment options for HCV infection are limited to PEG-ylated interferon alpha (IFN-α), the nucleoside ribavirin and the recently approved HCV protease inhibitors telaprevir and boceprevir. Although showing significantly improved efficacy over the previous therapies, treatment with protease inhibitors has been shown to result in the rapid emergence of drug-resistant virus. Here we report the activity of two proteins, originally isolated from natural product extracts, which demonstrate low or sub-nanomolar in vitro activity against both genotype I and genotype II HCV. These proteins inhibit viral infectivity, binding to the HCV envelope glycoproteins E1 and E2 and block viral entry into human hepatocytes. In addition, we demonstrate that the most potent of these agents, the protein griffithsin, is readily bioavailable after subcutaneous injection and shows significant in vivo efficacy in reducing HCV viral titers in a mouse model system with engrafted human hepatocytes. These results indicate that HCV viral entry inhibitors can be an effective component of anti-HCV therapy and that these proteins should be studied further for their therapeutic potential.
Creating curative communities: feminist group work with women with eating issues

The purpose of this study is to explore the efficacy of feminist group work for women with eating issues. Data for the study is drawn from participants involved in five therapeutic groups at the community based organisation, ISIS Centre for Women's Action on Eating Issues 1. Participants in this study completed the Eating Disorder Inventory (EDI) before and after group work and also responded to a post-group questionnaire which elicited their experiences of group work. Background information about ISIS and the model of group work at ISIS is provided. Following this, the EDI completed by participants and the post-group questionnaire are examined. The data reveals that feminist group work is a valuable therapeutic intervention for women with eating issues. The key to the effectiveness of group work is that it provides a curative culture.
L'évaluation des systèmes d'information : un état de l'art à la lumière des approches de la variance et processuelles

Les Systemes d’Information (SI) ont pris une place capita le dans les strategies des entreprises et ils mobilisent toujours aujourd’hui des sommes considerables. Leur evaluation apparait donc comme indispensable et capita le. Cet article propose de realiser un etat de l’art sur cette problematique de l’evaluation des SI en se focalisant sur les approches de la variance et processuelles. En premier lieu, il nous parait pertinent de situer la thematique de l’evaluation dans le champ de recherche des SI en insistant sur les principaux questionnements a mener pour toute evaluation. Dans un deuxieme temps, les approches theoriques de la variance et processuelles permettant d’evaluer les SI seront presentees. Enfin, il convient de presenter les deux modeles les plus emblematiques, ceux de Delone et Maclean (1992, 20 03) et de Davis et al. (1989).
Understanding Post-Devolution Elections in Scotland and Wales in Comparative Perspective

In this article, we explore the electoral dynamics of multi-level political systems for the case of the United Kingdom (Scotland and Wales) through a comparison with multi-level voting behaviour in Germany, Spain and Canada. The analysis suggests that sub-state elections can be `second order' in relation to state-wide elections, but that this `second orderness' is reduced when more powers are decentralized to the sub-state level (and, thus, more is at stake in sub-state elections), and if sub-state identities and parties are stronger. Consequently, elections in Scotland and Wales are unlikely to be or become only `second order' to Westminster elections, and British state-wide parties will continue to face challenges and pressures to adapt their organizations and programmes to the devolution of the British state.
Genetics and shell morphometrics of assimineids (Mollusca, Caenogastropoda, Truncatelloidea) in the St Lucia Estuary, South Africa

Abstract The Assimineidae are a family of amphibious microgastropods that can be mostly found in estuaries and mangroves in South Africa. These snails often occur in great numbers and are ecologically important to the St Lucia Estuary, which forms a crucial part of the iSimangaliso Wetland Park, a UNESCO World Heritage Site. Genetic and shell morphometric analyses were conducted on individuals collected from nine localities distributed from the northern lake regions to the southern lake and the mouth of the St Lucia estuarine lake. Mitochondrial (COI) and nuclear (28S) DNA was used to construct Bayesian Inference, Neighbour-joining, Maximum Parsimony and Maximum Likelihood trees. Principal Component Analysis and Cluster Analysis were performed on standard shell parameter data. Results indicate that two different taxa are present in St Lucia. The taxon comprising individuals from the South Lake and St Lucia Estuary Mouth is identified as Assiminea cf. capensis Bartsch, in accordance with the latest taxonomic consensus. The taxon comprising assimineid individuals from False Bay, North Lake and South Lake, is here tentatively named “Assiminea” aff. capensis (Sowerby). These two taxa exhibit patterns of spatial overlap that appear to vary depending on environmental parameters, particularly salinity. The need to resolve the complex taxonomy of assimineids is highlighted.
2 Running title : Effects D 2 and D 3 ligands on cocaine choice in rats

Affiliations: ACB and SBC: Alcohol and Drug Abuse Research Center, McLean Hospital and Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA. MT: Alcohol and Drug Abuse Research Center, McLean Hospital and Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA; and Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark
Effect of the Transition from Core Vowel to Following Segment on Frequency of Stuttering-Focus on Second Syllables-

: Earlier, we (Shimamori and Ito: 2007, 2008, 2009) suggested that the transition from the core vowel in first syllables to the following segment affects the frequency of stuttering in Japanese. However, the transition we investigated was in first syllables only, and the effect of the transition in second syllables was not addressed. The purpose of this study was to investigate whether the transition from core vowel to the following segment in second syllables also affects the frequency of stuttering. The participants were 33 elementary school children aged from 6 to 12 who stuttered. Two types of stimulus words were used: those with transition in the second syllables from core vowel to the following segment, and those without such transition. Naming and reading tasks were used. The frequency of stuttering in both tasks was not significantly different between the stimulus words with and without the transition in the second syllable. This result suggests that in second syllables, the transition from core vowel to the following segment might not affect the frequency of stuttering in Japanese.
Combined spinal‐extradural anaesthesia for Caesarean section

line insertion itself rather than insertion of the LMA. He also points out that laryngeal trauma may be avoided by use of an appropriate insertion technique and goes on to suggest how misplacement of the tip can be diagnosed. I was surprised that neither letter made mention of the potential of fibreoptic laryngoscopy in the diagnosis and management of these problems. Partial airway obstruction, such as occurred at the beginning of this case, can be rapidly and noninvasively assessed by passing a fibreoptic instrument down the LMA to the level of the mask aperture bars. Similarly, it can help diagnose misplacement of the LMA, allowing it to be repositioned if the tit, is lying in the laryngeal vestibule. The management of the airway in the presence of a bleeding disorder is always potentially hazardous. In circumstances where a facemask cannot be used, the LMA may be equally appropriate to a tracheal tube, or even a facemask plus oral airway, if airway maintainance is difficult. I would like to suggest that the presence of a bleeding disorder is only a relative contraindication to LMA insertion. When the LMA is used, it may be possible to reduce the risk of bleeding by inserting it slowly using the standard approach. Fibreoptic laryngoscopy, performed at insertion and regularly thereafter, will allow, the early detection of problems. Finally, this case serves to highlight the hazards of using the subclavian route for central line insertion in a patient with a bleeding diathesis. If the jugular veins had been used, persistent bleeding might have been simply managed with external pressure rather than general anaesthesia and surgical exploration.
Exogenous and Endogenous Factors Influencing Students' Performance in Undergraduate Accounting Modules

The objective of this study is to explore cross-sectionally the potential determinants of academic performance in undergraduate accounting modules for non-accounting degree students. The econometric model used in this study employs both student-oriented endogenous factors (e.g. age, gender) as well as student-exogenous factors (e.g. quality of teaching, examination structure). The univariate and multi-variate analyses indicate that both factors play a significant role in determining students' performance. The findings based on the implications of endogenous factors could provide some recommendations about university student admissions and budgeting policies, whilst those based on the implications of exogenous factors could help review students' assessment and academic staff recruitment policies, as well as the quality of teaching.
Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa

A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mutations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains.
Near-critical percolation in two dimensions

We give a self-contained and detailed presentation of Kesten's results that allow to relate critical and near-critical percolation on the triangular lattice. They constitute an important step in the derivation of the exponents describing the near-critical behavior of this model. For future use and reference, we also show how these results can be obtained in more general situations, and we state some new consequences.
Web readability for students with Dyslexia: Malaysian case study

Dyslexia is a specific reading disability in word recognition, spelling and decoding. Students with Dyslexia require special adjustments to the text and text environment to be able to read better. Current studies have shown that many assistive technologies such as software application and other tools are available in aiding Dyslexia's student in reading. However, websites that support Dyslexia's student in reading are very minimal. This discourages Dyslexia's student to use the Internet. Therefore there is a need to identify user-interface requirements for web readability for students with Dyslexia. The requirements are font style, font size, font color, background color and spacing. This is in line with result from several interviews conducted among educators in Dyslexia Titiwangsa Centre. By using the user-interface requirements, the researcher developed a prototype of web readability for students with mild stage of Dyslexia using Cascade Style Sheet (CSS). The reading ability of the Dyslexia's students in Dyslexia Titiwangsa Centre was tested on the prototype. The results showed that the Dyslexia's students were able to read better and easier when using built-in user-interface requirements in the website.
An Analysis Study of Improving Brand Awareness and Its Impact on Consumer Behavior Via Media in North Cyprus (A Case Study of Fast Food Restaurants)

The brand awareness has turned into an important variable that impacts customer's perceptions of a brand. Achievement in brand management arises from understanding and overseeing brand image and loyalty correctly to create strong characteristics that will impact consumers when making on their decisions.This thesis concentrates on the importance of these dimensions (brand awareness, brand loyalty, brand image and consumer behavior) of customer built brand equity in light of consumer's perceptions of a brand. This is focused around the assumption that all these dimensions of customer based-brand image and loyalty will have impact on consumer's perceptions of brand. However, this study aims to discover which among these three dimensions (brand image, brand loyalty and consumer behavior) seem to have the slightest brand equity in restaurants and to find out whether customer based-brand equity differ between fast food with respect to each characteristic of brand awareness, brand image, consumer behaviorand brand loyalty. Brand awareness was treated with independently from different dimensions because of the difference in scale, and moreover media and sorts of media affecting on consumer behavior. An organized survey was constructed to provide answers to research question. In this study, one hundred and fifteen questionnaires, on facilities available in the society, and technology were distributed. The research studied four dimensions of consumer's based-brand equity specifically brand awareness, brand image, perceived quality and brand loyalty. Among the three dimensions, brand loyalty seems to have the minimum brand equity rating by consumers than alternate dimensions. Although, the dimension seem to have impact on consumer perceptions of brand. This paper likewise provides a solution to brand awareness via media store sellers which may help the sellers to promote their products in light of consumer behavior.
Content‐Based Colour Transfer

This paper presents a novel content‐based method for transferring the colour patterns between images. Unlike previous methods that rely on image colour statistics, our method puts an emphasis on high‐level scene content analysis. We first automatically extract the foreground subject areas and background scene layout from the scene. The semantic correspondences of the regions between source and target images are established. In the second step, the source image is re‐coloured in a novel optimization framework, which incorporates the extracted content information and the spatial distributions of the target colour styles. A new progressive transfer scheme is proposed to integrate the advantages of both global and local transfer algorithms, as well as avoid the over‐segmentation artefact in the result. Experiments show that with a better understanding of the scene contents, our method well preserves the spatial layout, the colour distribution and the visual coherence in the transfer process. As an interesting extension, our method can also be used to re‐colour video clips with spatially‐varied colour effects.
Imagined adulthood under transition – Somali-Swedish girls’ life-planning in a late modernity context

This article examines how Muslim girls of Somali origin raised in Sweden imagine their adulthood in regard to career and family life. The theoretical framework is social constructionist in that it assumes that children have agency and are capable and competent actors, in contrast to what has previously been generally assumed about children from ethnic minorities, particularly Muslim girls. The qualitative study consists of an analysis of girls' essays. The findings reveal that their dreams are both consistent with the expectations of their families (in particular, high educational ambitions) and inspired from elsewhere (particularly in terms of future family life). How the girls imagine their adulthood may be seen as an example of how their original culture is subject to change in a new environment that influences possibilities, the pace of detraditionalisation and the extent of individualisation, all of which are typical characteristics of a society in late modernity.
Interactions of Cipazoxapine, Citatepine, Eresepine, and Maroxepine with Central Dopamine (DA) Receptors: Effects on in Vivo (3H)Spiperone Binding, DA Metabolism, and Behavioral Parameters

Our concept on blockade of DA receptors in hippocampus as an indicator for the antipsychotic efficacy of a compound (Bischoff et al., 1985; 1986; Bischoff, 1986) was applied to the search for novel neuroleptics. Four substances of a new chemical class, namely of a tetracyclic structure (for the structure see Waldmeier et al., 1986) were selected accord· ing a) to their antidopaminergic activities and b) to their preference for hippocampal DA receptors as compared to striatum.
On understanding the nature of scientific knowledge

One important goal of science education is to help students understand the nature of the scientific enterprise itself. We review data from several sources, indicating that middle school and high school students have a common sense epistemology of science at variance with the constructivist epistemology we advocate as the appropriate curricular goal. We sketch the student epistemology and discuss two attempts to induce changes in it through science education.
Activation, health and well‐being: neglected dimensions?

Purpose – This article argues that some of the most profound costs of unemployment are social in nature, rather than solely economic. Consequently, the aim of the paper is to argue that the design and evaluation of active labour market policies (ALMPs) should incorporate a better and more sophisticated understanding of how such interventions affect the health, well‐being and social exclusion of the unemployed, as opposed to more typically economic outcomes like re‐employment and wage levels.Design/methodology/approach – To achieve this, a range of theoretical and empirical evidence is reviewed that shows how unemployment is consistently associated with a range of health and social problems. Evidence is also presented that demonstrates the capacity that ALMPs have to intervene and mediate such problems.Findings – The evidence presented demonstrates that not only is unemployment associated with a range of health and social problems but it appears to have a causal function. Further, the evidence also demonst.
The female terrorist: A socio-psychological perspective

This article deals with the female terrorist, her socio-psychological characteristics, and her role within the terrorist organization. There is no archetypal female terrorist; her description is varied from her physique to her role within the organization to her psychological make-up. Women take up terrorism either by their own initiative or through a secondary other, most often introduced into it by a male. Although women terrorists have the equality to fight or die by the side of their male counterparts, their power position frequently is less than that of the male. The female's sexuality plays an important role in the group dynamics and does alter the nature of terrorism itself. The article explores the implications of these findings for the future of terrorism and the participation of women.
Triticeous Cartilage CT Imaging Characteristics, Prevalence, Extent, and Distribution of Ossification

Objective The triticeous cartilage is a small ovoid cartilaginous structure variably present as a component of the laryngeal skeleton. This structure has received scant attention in the literature and has yet to be described adequately on cross-sectional imaging. Study Design and Setting Retrospective study in a tertiary medical center. Subjects and Methods We investigated triticeous cartilage prevalence in a large population utilizing computed tomography images. The cases of all patients with computed tomography angiography images of the neck from October 1, 2013, to September 31, 2014, were examined. A total of 663 patients were included in this study (age: range, 18-97 years; mean ± SD, 65 ± 15 years), 58.4% men and 41.6% women. The presence of a triticeal cartilage and its site, number, and degree of ossification were recorded. Results A total of 53.1% of patients had at least 1 triticeous cartilage (352 of 663). Prevalence was 57.4% (222 of 387) among men and 47.1% (130 of 276) among women. The presence of bilateral triticeous cartilages was more common than unilateral (63.1%, 222 of 352). A minority of patients (4.5%, 16 of 352) had a cartilaginous triticeous with no appreciable ossification, and more than half (54.0%, 190 of 352) had mild triticeal ossification. Moderate ossification was found in 34.9% of patients (123 of 352) and marked ossification in 6.5% (23 of 352). Conclusion The presence of a triticeous cartilage is common and of variable appearance. As the clinical and surgical significance of this anatomic structure may be misinterpreted, it is important for imaging interpreters to be familiar with this seldom-recognized anatomic structure and recognize its variable appearance on cross-sectional imaging to avoid a misdiagnosis.
Cross-Cultural Application of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Performances of Elderly Chinese Singaporeans

There is a paucity of normative studies outside of North America and on elderly populations with very low education level. In the present study we examined the performance of poorly educated elderly on the Repeatable Battery Assessment of Neuropsychological Status (RBANS) with 352 cognitively normal elderly Chinese persons living in the community in Singapore who were enrolled in the Singapore Longitudinal Ageing Study (SLAS). Those with no formal education performed significantly less well than those with some years of formal education across four of five RBANS indices as well as the Total Scale score. Age- and education-adjusted normative data for the RBANS were established for the sample. The means and standard deviations of each of 12 subtests raw scores, five Index scores and the Total Scale score were calculated and stratified by age and education. Data from the present study should considerably advance the clinical utility of the RBANS in Chinese geriatric evaluations in Singapore, and can serve as a reference source for poorly educated elderly Chinese from around the region and beyond.