Miracle-dz/UniFAR-FTUs huggingface dataset:
Representation of interaural time difference in the central nucleus of the barn owl's inferior colliculus

This paper investigates the role of the central nucleus of the barn owl's inferior colliculus in determination of the sound-source azimuth. The central nucleus contains many neurons that are sensitive to interaural time difference (ITD), the cue for azimuth in the barn owl. The response of these neurons varies in a cyclic manner with the ITD of a tone or noise burst. Response maxima recur at integer multiples of the period of the stimulating tone, or, if the stimulus is noise, at integer multiples of the period corresponding to the neuron's best frequency. Such neurons can signal, by means of their relative spike rate, the phase difference between the sounds reaching the left and right ears. Since an interaural phase difference corresponds to more than one ITD, these neurons represent ITD ambiguously. We call this phenomenon phase ambiguity. The central nucleus is tonotopically organized and its neurons are narrowly tuned to frequency. Neurons in an array perpendicular to isofrequency laminae form a physiological and anatomical unit; only one ITD, the array-specific ITD, activates all neurons in an array at the same relative level. We, therefore, may say that, in the central nucleus, an ITD is conserved in an array of neurons. Array-specific ITDs are mapped and encompass the entire auditory space of the barn owl. Individual space-specific neurons of the external nucleus, which receive inputs from a wide range of frequency channels (Knudsen and Konishi, 1978), are selective for a unique ITD. Space-specific neurons do not show phase ambiguity when stimulated with noise (Takahashi and Konishi, 1986). Space-specific neurons receive inputs from arrays that are selective for the same ITD. The collective response of the neurons in an array may be the basis for the absence of phase ambiguity in space-specific neurons.
To Fear Is to Gain? The Role of Fear Recognition in Risky Decision Making in TBI Patients and Healthy Controls

Fear is an important emotional reaction that guides decision making in situations of ambiguity or uncertainty. Both recognition of facial expressions of fear and decision making ability can be impaired after traumatic brain injury (TBI), in particular when the frontal lobe is damaged. So far, it has not been investigated how recognition of fear influences risk behavior in healthy subjects and TBI patients. The ability to recognize fear is thought to be related to the ability to experience fear and to use it as a warning signal to guide decision making. We hypothesized that a better ability to recognize fear would be related to a better regulation of risk behavior, with healthy controls outperforming TBI patients. To investigate this, 59 healthy subjects and 49 TBI patients were assessed with a test for emotion recognition (Facial Expression of Emotion: Stimuli and Tests) and a gambling task (Iowa Gambling Task (IGT)). The results showed that, regardless of post traumatic amnesia duration or the presence of frontal lesions, patients were more impaired than healthy controls on both fear recognition and decision making. In both groups, a significant relationship was found between better fear recognition, the development of an advantageous strategy across the IGT and less risk behavior in the last blocks of the IGT. Educational level moderated this relationship in the final block of the IGT. This study has important clinical implications, indicating that impaired decision making and risk behavior after TBI can be preceded by deficits in the processing of fear.
Investigation of the axial compressive behavior of Kevlar fibers using the dynamic loop test

A dynamic loop test method for measuring strain rate-dependent fiber properties was developed. During dynamic loop testing, the fiber ends are accelerated at constant levels of 20.8, 50 and 343 m/s2. The test method is used to study Kevlar® KM2-600, which fails in axial compression due to kink band formation. The compressive failure strain and strain rate at the onset of kink band formation is calculated from the critical loop diameter (D C ), which is monitored throughout the test using a high-speed camera. The results showed that compressive failure strain increases with strain rates from quasi-static to a maximum strain rate of 116 s−1 by a factor of ∼3. Kink angles (φ) and kink band spacing (D S ) were 60 ° ± 2 ° and 16 ± 3 μm, respectively, over the strain rates tested. Rate-dependent mechanisms of compressive failure by kink band formation were discussed.
Aphasia rehabilitation in Australia: Current practices, challenges and future directions

Abstract This study reports on current aphasia rehabilitation practices of speech-language pathologists in Australia. A 30-item web-based survey targeted approaches to aphasia rehabilitation, education, discharge, follow-up practices, counselling, interventions to improve communication access, community aphasia support services, and challenges to practice. One hundred and eighty-eight surveys were completed representing ˜ 33% of the potential target population, with 58.5% urban and 41.5% rural participants across all states and territories. Respondents reported embracing a wide variety of approaches to aphasia rehabilitation; however, significant challenges in providing aphasia management in acute and residential care were identified. Low levels of knowledge and confidence were reported for both culturally and linguistically diverse clients and discourse approaches. Group and intensive services were under-utilized and clinicians reported inflexible funding models as major barriers to implementation. Few clinicians work directly in the community to improve communicative access for people with aphasia. Despite the chronic nature of aphasia, follow-up practices are limited and client re-entry to services is restricted. Counselling is a high frequency practice in aphasia rehabilitation, but clinicians report being under-prepared for the role. Respondents repeatedly cited lack of resources (time, space, materials) as a major challenge to effective service provision. Collective advocacy is required to achieve system level changes.
Molecular dynamics study of HIV‐1 RT‐DNA‐nevirapine complexes explains NNRTI inhibition and resistance by connection mutations

HIV‐1 reverse transcriptase (RT) is a multifunctional enzyme that is targeted by nucleoside analogs (NRTIs) and non‐nucleoside RT inhibitors (NNRTIs). NNRTIs are allosteric inhibitors of RT, and constitute an integral part of several highly active antiretroviral therapy regimens. Under selective pressure, HIV‐1 acquires resistance against NNRTIs primarily by selecting mutations around the NNRTI pocket. Complete RT sequencing of clinical isolates revealed that spatially distal mutations arising in connection and the RNase H domain also confer NNRTI resistance and contribute to NRTI resistance. However, the precise structural mechanism by which the connection domain mutations confer NNRTI resistance is poorly understood. We performed 50‐ns molecular dynamics (MD) simulations, followed by essential dynamics, free‐energy landscape analyses, and network analyses of RT‐DNA, RT‐DNA‐nevirapine (NVP), and N348I/T369I mutant RT‐DNA‐NVP complexes. MD simulation studies revealed altered global motions and restricted conformational landscape of RT upon NVP binding. Analysis of protein structure network parameters demonstrated a dissortative hub pattern in the RT‐DNA complex and an assortative hub pattern in the RT‐DNA‐NVP complex suggesting enhanced rigidity of RT upon NVP binding. The connection subdomain mutations N348I/T369I did not induce any significant structural change; rather, these mutations modulate the conformational dynamics and alter the long‐range allosteric communication network between the connection subdomain and NNRTI pocket. Insights from the present study provide a structural basis for the biochemical and clinical findings on drug resistance caused by the connection and RNase H mutations. Proteins 2014; 82:815–829. © 2013 Wiley Periodicals, Inc.
Shear behavior of recycled concrete beam from building wastes

There are six beams made from recycled concrete and one from common concrete in the test. We conduct a shear test on them to analyze how the fracture morphologies, shear capacity and oblique crack width of beams are subjected to change with the replacement rate and shear-span ratio of recycled aggregates. The results reveal that the two fracture morphologies, i.e. shear stress and oblique tension, occur on the recycled concrete beams. Shear span ratio is still the dominant factor that affects the failure mode and load capacity of recycled concrete beams. In the end, this paper proposes the computation formula for the ultimate flexural and shear capacities of recycled concrete beams, which provides a reference for further exploration and application of recycled concrete in structures.
A Comparison of Sodium Lignosulfonate (SLS) Synthesis from Black Liquor Lignin and Commercial Lignin

Sulphonation of lignin has been considered as a promising step to produce lignosulfonate which may serve as dispersant, flocculant, and surfactant. The aim of present study was to compare the synthesis of sodium lignosulfonate (SLS) from different lignin feedstocks namely commercial lignin and lignin isolated from black liquor (BL) of pulp and paper industry. A novel technique to isolate lignin from BL was introduced with the aid of CO2 and coagulant of alumunium sulfate. The FTIR spectra of BL lignin showed similarity with commercial lignin which indicates that the isolation of BL lignin with the present technique did not alter the chemical structure of lignin. Furthermore, sulphonation of commercial and BL lignin with NaHSO3 solution has been conducted to obtain SLS powder. In general, the FTIR spectra of SLS from commercial and BL lignin were similar to their parent lignin. However, absorption peak which corresponds to SO3 vibration was lightly detected on both samples which indicated the insertion of SO3 functional group into the lignin structure. The ability of SLS to increase the oil mobility for Enhanced Oil Recovery (EOR) was measured from the interfacial tension (IFT). Our results showed that the IFT values of SLS solution from commercial lignin and BL lignin were 0.3759 mN/m and 0.2675 mN/m, respectively. Further formulation of SLS from BL lignin with octanol and PFAD solution may lower the IFT value to 0.0186 mN/m.
Prehospital versus periprocedural abciximab in ST -elevation myocardial infarction treated by percutaneous coronary intervention

Objective To investigate the potential benefit of an earliest possible out-of-hospital start of abciximab (ReoPro) therapy in ST-elevation myocardial infarction (STEMI; Lilly, Bad Homburg, Germany) and planned primary percutaneous intervention compared with periprocedural abciximab treatment on reperfusion and clinical outcome. Methods Randomization of one hundred and one patients with STEMI to prehospital or periprocedural abciximab treatment. Evaluation of thrombolysis in myocardial infarction (TIMI) flow, ST-segment resolution, myocardial blush grade, and maximal creatine kinase release before and after as well as clinical follow-up until 6 months after the index event. Results Prehospital abciximab (group 1) was initiated a median of 101 min (37–165 min) earlier compared with periprocedural treatment (group 2). Initial TIMI 3 flow (24 vs. 15%, P=NS), ST-segment resolution before percutaneous coronary intervention (PCI) (<30%: 33 vs. 46%, P=NS; >70%: 38 vs. 33%, P=NS), post-PCI myocardial blush grade 2 and 3 (72 vs. 75%, P=NS), maximal cardiac enzyme release (creatinine kinase MB median 77 U/l; range 33–137 vs. 74 U/l; range 39–143 U/l, P=NS), and 6 months follow-up (recurrent myocardial infarction or repeat coronary intervention, and PCI, need for coronary bypass surgery) did not differ significantly between both treatment groups. Conclusion Prehospital intravenous administration of abciximab, although safe and feasible in a trained surrounding, does not add angiographic or clinical benefit to patients with STEMI.
Effects of visuospatial tasks on desensitization to emotive memories.

OBJECTIVES Intrusive memories of extreme trauma can disrupt a stepwise approach to imaginal exposure. Concurrent tasks that load the visuospatial sketchpad (VSSP) of working memory reduce the vividness of recalled images. This study tested whether relief of distress from competing VSSP tasks during imaginal exposure is at the cost of impaired desensitization. DESIGN This study examined repeated exposure to emotive memories using 18 unselected undergraduates and a within-subjects design with three exposure conditions (Eye Movement, Visual Noise, Exposure Alone) in random, counter-balanced order. METHOD At baseline, participants recalled positive and negative experiences, and rated the vividness and emotiveness of each image. A different positive and negative recollection was then used for each condition. Vividness and emotiveness were rated after each of eight exposure trials. At a post-exposure session 1 week later, participants rated each image without any concurrent task. RESULTS Consistent with previous research, vividness and distress during imaging were lower during Eye Movements than in Exposure Alone, with passive visual interference giving intermediate results. A reduction in emotional responses from Baseline to Post was of similar size for the three conditions. CONCLUSION Visuospatial tasks may offer a temporary response aid for imaginal exposure without affecting desensitization.
Toward Trait-Based Mortality Models for Tropical Forests

Tree mortality in tropical forests is a complex ecological process for which modelling approaches need to be improved to better understand, and then predict, the evolution of tree mortality in response to global change. The mortality model introduced here computes an individual probability of dying for each tree in a community. The mortality model uses the ontogenetic stage of the tree because youngest and oldest trees are more likely to die. Functional traits are integrated as proxies of the ecological strategies of the trees to permit generalization among all species in the community. Data used to parametrize the model were collected at Paracou study site, a tropical rain forest in French Guiana, where 20,408 trees have been censused for 18 years. A Bayesian framework was used to select useful covariates and to estimate the model parameters. This framework was developed to deal with sources of uncertainty, including the complexity of the mortality process itself and the field data, especially historical data for which taxonomic determinations were uncertain. Uncertainty about the functional traits was also considered, to maximize the information they contain. Four functional traits were strong predictors of tree mortality: wood density, maximum height, laminar toughness and stem and branch orientation, which together distinguished the light-demanding, fast-growing trees from slow-growing trees with lower mortality rates. Our modelling approach formalizes a complex ecological problem and offers a relevant mathematical framework for tropical ecologists to process similar uncertain data at the community level.
Income Inequality and Job Satisfaction of Full-Time Employees in Germany

Using data from the German Socio-Economic Panel Study (SOEP), it is shown that income comparisons with persons who are better off has a clear impact on the job satisfaction of West German full-time employees. Two contrary effects can be identified. On the one hand, there is an aversion to disadvantageous regional income inequality, while, on the other hand, individuals prefer inequality within their occupational group. The two effects are interpreted as envy and an information (or ‘tunnel’) effect, respectively. The analysis of income comparison with persons who are worse off suggests a prestige effect. However, downward comparison is of minor importance for job satisfaction.
Attitudes towards and Beliefs about HIV Testing among Latino Immigrant MSM: A Comparison of Testers and Nontesters

Latino immigrant men who have sex with men (MSM) are at risk for HIV and delayed diagnosis. An exploratory study using qualitative interviews that assess the beliefs and attitudes of 54 Latino immigrant MSM in Seattle, Washington, is presented. The goal of this research is to determine whether attitudinal differences exist between participants who had and had not been tested and to use any insight into the development of a media campaign to promote testing. Over one-third of the men have never been tested for HIV. Nontesters are more likely to be men who have sex with men and women, have less knowledge about HIV risks, perceive their sexual behaviors as less risky, and deflect HIV-related stigma. Testers are more likely to be self-identified as being gays. Both groups believe that fear of a positive result is the main barrier to testing. Both groups believe that family members have negative attitudes towards HIV testing and that having Latino staff at HIV testing sites hinders confidentiality. Financial concerns with regard to the cost of testing were also expressed by both groups. Based on these insights, recommended strategies for the development of HIV prevention and testing campaigns are made.
High-dimensional Ising model selection using ℓ1-regularized logistic regression

We consider the problem of estimating the graph associated with a binary Ising Markov random field. We describe a method based on $\ell_1$-regularized logistic regression, in which the neighborhood of any given node is estimated by performing logistic regression subject to an $\ell_1$-constraint. The method is analyzed under high-dimensional scaling in which both the number of nodes $p$ and maximum neighborhood size $d$ are allowed to grow as a function of the number of observations $n$. Our main results provide sufficient conditions on the triple $(n,p,d)$ and the model parameters for the method to succeed in consistently estimating the neighborhood of every node in the graph simultaneously. With coherence conditions imposed on the population Fisher information matrix, we prove that consistent neighborhood selection can be obtained for sample sizes $n=\Omega(d^3\log p)$ with exponentially decaying error. When these same conditions are imposed directly on the sample matrices, we show that a reduced sample size of $n=\Omega(d^2\log p)$ suffices for the method to estimate neighborhoods consistently. Although this paper focuses on the binary graphical models, we indicate how a generalization of the method of the paper would apply to general discrete Markov random fields.
Analysis of Tie2-Expressing Monocytes (TEM) in Patients With Colorectal Cancer

Tie2-expressing monocytes (TEM) promote tumor angiogenesis and growth in experimental cancer models. The role of TEM in cancer patients is unknown. We studied TEM in healthy volunteers and colorectal cancer (CRC) patients. Although TEM were detectable in the blood and tumor lesions of CRC patients, their frequency and functional phenotype showed no correlation with levels of angiopoietin-2 or vascular endothelial growth factor, microvessel density, tumor markers, tumor stage, or outcome of antiangiogenic therapy. These unexpected findings are at odds with murine tumor models and question the diagnostic or therapeutic value of TEM in human cancer.
Sources of Migrant Housing Disadvantage in Urban China

The increasing level of labor mobility in China challenges the current population-management structure. In particular, recent reforms in urban housing provision seem largely to overlook the needs of the migrant population. In this paper I examine the sources of migrant housing disadvantage in cities. Specifically, I analyze the institutional and socioeconomic factors underlying migrant housing choice and conditions, and how these factors influence migrants differently from the locals. Data are drawn primarily from citywide housing surveys and interviews conducted in Shanghai and Beijing. The findings show that migrants make housing decisions based on whether they intend to settle in the cities, and market-related factors such as income and education have a significant, positive impact on migrant housing conditions. But more importantly, the general disadvantage experienced by migrants has much of its root in the institutional restrictions associated with the hukou system that outweigh the combined effects of socioeconomic factors.
Impact of Genetic Abnormalities on the Prognoses and Clinical Parameters of Patients with Multiple Myeloma

Background We reviewed patients with multiple myeloma (MM) in order to assess the incidence of genetic abnormalities and their associations with clinical parameters, risk groups, and prognosis. Methods A total of 130 patients with MM were enrolled. The incidences of genetic abnormalities were determined in all patients. The relationships of the genetic abnormalities and clinical parameters were investigated. In addition, a survival analysis was performed. Results Abnormal karyotypes were detected in 42.3% (N=55) of the patients, and this was increased to 63.1% (N=82) after including the results determined with interphase FISH. Hypodiploidy was observed in 7.7% (N=10) of the patients, and all were included in the group with complex karyotypes (30.8%, N=40). The 14q32 rearrangements were detected in 29.2% (N=38) of the patients, and these most commonly included t(11;14), which was followed by t(4;14) and t(14;16) (16.2%, 11.5%, and 0.8%, respectively). Abnormal karyotypes and complex karyotypes were associated with disease progression markers, including low hemoglobin levels, low platelet counts, high plasma cell burden, high β2-microglobulin, and high international staging system stages. A high free light chain (FLC) ratio and FLC difference were associated with abnormal karyotypes, complex karyotypes, and higher plasma cell burden. Hypodiploidy and low platelet counts were significant independent prognostic factors and were more important in patient outcome than any single abnormality. Conclusions Genetic abnormalities were associated with disease progression markers and prognosis of MM patients.
Contrasting physical activity patterns in children and adolescents living in differing environments in the UK

Aims: There is evidence for lower physical activity (PA) in rural adults; it is important to evaluate how the environment influences the PA of children and adolescents. Methods: We compared the PA of 6485 English 10—15.9 year olds according to two systems for classifying the immediate environment. System one compared urban and rural areas. System two compared urban, town and fringe, and rural areas. Analyses were carried out separately for children (<13 years) and adolescents (>13 years). Results: Rural children were more active than those from urban areas (OR 1.38, 95% CI 1.15—1.66) as were adolescents (OR 1.30, 95% CI 1.11—1.51). Using trilateral division, children were more active if they lived in town and fringe (OR 1.32, 95% CI 1.03—1.67) or rural (OR 1.45, 95% CI 1.14—1.84) areas compared with urban areas. Adolescents from town and fringe areas were more active than urban dwellers (OR 1.50, 95% CI 1.24—1.81). Rural adolescents’ PA did not differ from urban dwellers’. Conclusions: Rural environments support PA in children but not that of adolescents. Town and fringe areas with mixed elements of rural and urban land use appear to facilitate and sustain PA in both children and adolescents.