Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacotherapy options for cataplexy

Introduction: Narcolepsy with cataplexy is a rare disabling sleep disorder characterized by two major symptoms: excessive daytime sleepiness and cataplexy characterized by a sudden bilateral loss of voluntary muscular tone triggered by strong positive emotional factors. Pathophysiological studies have shown that the disease is caused by the early loss of hypothalamic hypocretin neurons. Areas covered: Following a literature search on PubMed using “narcolepsy,” “cataplexy,” “treatment,” “medication,” and “drug” as keywords, we critically analyzed and reviewed current evidence about optimal management of cataplexy in humans. The management of cataplexy has evolved over the past few years with the widespread use of antidepressants, especially those with adrenergic uptake inhibitor properties and gamma-hydroxybutyrate (sodium oxybate). Expert opinion: Based on class 1 evidence studies, first-line pharmacological treatment of cataplexy should be sodium oxybate. Second-line treatment should be antidepressants with norepinephrine/serotonine reuptake inhibitor venlafaxine based on its good benefit–risk ratio; however, this recommendation lacks class 1 evidence and is based on expert opinion only. Given the major developments in understanding the neurobiological basis of cataplexy, future therapeutic targets are clearly oriented toward immune-based therapies at early stages of the disease and hypocretin replacement therapy.
Microprocessor‐Controlled Nd:YAG laser for hyperthermia induction in the RIF‐1 tumor

Near‐infrared radiation from a Nd:YAG laser at 1,064 nm was used interstitially or superficially to induce hyperthermia in RIF‐1 tumors in C3H male mice. A single 600‐μm quartz fiber with a 0.5‐cm cylindrical diffusor or a weakly diverging microlens at its distal end was used to deliver laser energy to tumors in the hind leg (mean volume = 100 mm3). Two thermocouples were inserted into each tumor. One thermocouple controlled a microprocessor‐driven hyperthermia program (maximum output of 3.5 Watts) to maintain the desired temperature. Tumors were exposed to various temperature‐time combinations (42–45°C/30 min). Our initial results indicated that excellent temperature control to within 0.2°C of the desired temperature at the feedback thermocouple was achievable during both superficial and interstitial heat treatments. Temperatures at the second thermocouple, however, were found to be lower by as much as 2.3°C (using the cylindrical diffusor) or higher by up to 4.6°C (using the microlens) when compared to the feedback thermocouple temperature. Several correlations were seen between total dose, tumor growth delay, percent skin necrosis, and temperature at the second thermocouple after several superficial and interstitial treatments. Statistically significant improvements in tumor growth delay (at 42 and 45°C) and increased percent skin necrosis at all temperatures were observed after superficial versus interstitial treatment. © 1992 Wiley‐Liss, Inc.
Allometry of cells and tissues within leaves.

UNLABELLED PREMISE OF THE STUDY Allometric relationships among the dimensions of leaf cells, cell walls, and tissues, and whole-leaf thickness and area are likely to have key implications for leaf construction and function, but have remained virtually untested, despite the explosion of interest in allometric analysis of numerous plant properties at larger scales. • METHODS Using leaf transverse cross sections and light microscopy, we measured leaf dimensions, tissue thicknesses, mesophyll and xylem cell sizes, and cell wall thicknesses for 14 diverse angiosperm species of wet and dry habitats and tested hypothesized allometric relationships based on geometric scaling due to development and/or function. • KEY RESULTS We found strong novel allometries relating the dimensions of cells, cell walls, tissues, and gross leaf form. Cell sizes and cell wall thicknesses tended to scale isometrically across mesophyll tissues within the leaf, such that species with large cells or thick cell walls in one tissue had these also in the other tissues; however, leaf vein xylem conduit sizes were independent of those of other cell types. We also found strong geometric scaling of cell wall thicknesses with cell sizes throughout the mesophyll, but not in the leaf vein xylem. Further, leaf thickness scaled with cell sizes, cell wall thicknesses and the thicknesses of component mesophyll tissues, but leaf area was independent of anatomical traits across species. • CONCLUSIONS These novel allometries suggest design rules operating at the smallest scales of leaf construction and the possibility of applying these relationships to better characterizing the basis for differences among species in leaf form and functional traits.
INFLUENCE OF PROPYLTHIOURACIL TREATMENT ON OXIDATIVE STRESS AND NITRIC OXIDE IN BASEDOW DISEASE PATIENTS

Oxidative stress parameters and nitric oxide (NO) values were determined in 27 newly diagnosed Basedow patients before and after 1 mo of propylthiouracil (PTU) therapy and in 15 healthy controls. Basedow patients exhibited increased triiodothyronine (T3) and thyroxine (T4
Comparison of ICE (Ifosfamide-Carboplatin-Etoposide) Versus DHAP (Cytosine Arabinoside-Cisplatin-Dexamethasone) as Salvage Chemotherapy in Patients with Relapsed or Refractory Lymphoma

Background: High dose chemotherapy with autologous stem cell transplantation is currently the treatment of choice for relapsed or refractory lymphoma patients. However, its applicability is mostly restricted to patients responding to salvage chemotherapy. Optimal salvage regimen for these patients is unclear. In this study, our aim was to compare the efficacy and toxicity profiles of DHAP (cytosine arabinoside, cisplatin and dexamethasone) and ICE (ifosfamide, carboplatin and etoposide) regimens in the salvage treatment of relapsed and refractory lymphoma. Patients and Methods: In this retrospective analysis, 53 patients with primary refractory or relapsed Hodgkin's disease (HD) (n = 13) or non-Hodgkin lymphoma (NHL) (n = 40) who received ICE or DHAP salvage regimen were included. Results: Of 53 patients, 21 (39,6%) were female and the median age was 43 years. A total of 73 courses of ICE and 59 courses of DHAP were administered. Response could be evaluated in 49 patients (36 NHL and 13 HD). Of 49 patients, 11 (22.5%) achieved complete remission (CR) and 17 (35%) achieved partial remission (PR), leading to an overall response rate (ORR: CR + PR) of 57.5%. In the evaluable ICE group (n = 22) rates of CR, PR, and ORR were 27%, 41% and 68% and in the DHAP group (n = 27) rates of CR, PR, and ORR were 18%, 30% and 48% (p = 0.24, for ORR). Toxicity with both regimens was within acceptable limits. The major grade III–IV toxicities for both groups were hematological (neutopenia and thrombocytopenia). The main non-hematological toxicity was renal and observed in 8 patients. Conclusion: Although the toxicity profiles of both ICE and DHAP regimens were similar in the treatment of patients with relapsed or refractory HD or NHL, ICE seems to have higher rates of response than DHAP regimen does.
Anatomy and physiology of experimentally produced striped tecta

Transplantation of a third eye primordium to the forebrain region of a frog (Rana pipiens) embryo causes two retinal projections to converge on a single tectal lobe. These projections form stereotyped eye- specific termination bands (Constantine-Paton, M., and M. I. Law (1978) Science 202: 639–641) that are similar to the source-specific stripes found normally in many regions of the mammalian brain. In the present study, we use quantitative analyses of anatomical data and double labeling techniques to demonstrate that induced bands of three-eyed frogs are approximately 200 micrometers wide, that they invariably run in a rostrolateral to caudomedial direction, and that they represent interdigitating synaptic zones which fill the entire superficial neuropil of the dually innervated tectal lobe. This periodic segregation pattern is not seen in the superinnervated diencephalon or in the optic tracts. Morphometric measurements on animals with dually innervated tectal lobes revealed an approximate 30% hyperplasia that was restricted largely to the deeper predominantly cellular tectal layers. Each of the banded retinal projections occupied neuropil volumes that were roughly 50% smaller than the volume occupied by the noncompeting retina of the same animal. Eye-specific segregation was detected with extracellular recording techniques as an ability of one of the two eyes to elicit consistently more and larger action potentials throughout a radial penetration of the superficial tectal neuropil. In several preparations, electrolytic lesions confirmed that physiologically defined positions of eye dominance corresponded to a band from the same eye. Maps of the visual field projections within dually innervated tecta were relatively normal and their orientation was consistent with the initial embryonic orientation of the retinas. Eye laterality, time of arrival, or fasciculation during growth are not responsible for this induced banding. Instead, our results are attributed to two mechanisms that are probably fundamental to neural mapping. These are: differential affinities between retinal and tecta loci which normally align the projection by bringing together appropriate pre- and postsynaptic areas and interactions among retinal ganglion cell fibers. The latter causes axons from physically neighboring retinal ganglion cell bodies to terminate together within the tectum and consequently increases the internal order of map. We propose that these same two mapping mechanisms may be responsible for the afferent segregation found in diverse regions of many vertebrate brains.
Multiple sclerosis and psychological well-being : the role of physical and psychosocial factors

Multiple sclerosis, (MS), presents affected individuals with an uncertain future, and has broad physical and psychosocial implications for their daily functioning. This study aimed to investigate the psychological well-being of people with MS with an emphasis on positive psychological functioning. It also aimed to extend previous research that suggested reporting perceived benefits during adversity may be indicative of cognitive adaptation. Disease-related variables (mobility, fatigue) and psychosocial factors (optimism, coping) were examined to ascertain the effects of living with MS upon wellbeing. Well-being was determined using two general measures (The Profile of Mood States (POMS), Shacham, 1983; and the Ryff Psychological Well-being Scale (PWB), Ryff & Keyes, 1995), and Mohr et al.’s (1999) MS psychosocial factors (Demoralization, Deteriorated Relationships, Benefit Finding). Participants were 154 people with MS who were recruited through the MS Societies of Victoria and Tasmania. Results showed participants reported both negative and positive consequences from their MS experiences. Higher levels of Demoralization and Deteriorated Relationships were related to decreased well-being. However, no association was found between Benefit Finding and psychological well-being. Benefit Finding was also unrelated to optimism, and the disease-related variables (mobility, fatigue). Only positive reappraisal coping was predictive of reporting of benefits which lends support to the notion that it is a coping strategy. To examine the effects of mobility the sample was divided into three groups: normal gait, mild gait problems but not using aids and those who require aids for mobility. Significant differences between
Specificity of regions processing biological motion

Using functional magnetic resonance imaging and point light displays portraying six different human actions, we were able to show that several visual cortical regions, including human MT/V5 complex, posterior inferior temporal gyrus and superior temporal sulcus, are differentially active in the subtraction comparing biological motion to scrambled motion. Comparison of biological motion to three‐dimensional rotation (of a human figure), articulated motion and translation suggests that human superior temporal sulcus activity reflects the action portrayed in the biological motion stimuli, whereas posterior inferior temporal gyrus responds to the figure and hMT/V5+ to the complex motion pattern present in biological motion stimuli. These results were confirmed with implied action stimuli.
The evolutionary neuroscience of musical beat perception: the Action Simulation for Auditory Prediction (ASAP) hypothesis

Every human culture has some form of music with a beat: a perceived periodic pulse that structures the perception of musical rhythm and which serves as a framework for synchronized movement to music. What are the neural mechanisms of musical beat perception, and how did they evolve? One view, which dates back to Darwin and implicitly informs some current models of beat perception, is that the relevant neural mechanisms are relatively general and are widespread among animal species. On the basis of recent neural and cross-species data on musical beat processing, this paper argues for a different view. Here we argue that beat perception is a complex brain function involving temporally-precise communication between auditory regions and motor planning regions of the cortex (even in the absence of overt movement). More specifically, we propose that simulation of periodic movement in motor planning regions provides a neural signal that helps the auditory system predict the timing of upcoming beats. This “action simulation for auditory prediction” (ASAP) hypothesis leads to testable predictions. We further suggest that ASAP relies on dorsal auditory pathway connections between auditory regions and motor planning regions via the parietal cortex, and suggest that these connections may be stronger in humans than in non-human primates due to the evolution of vocal learning in our lineage. This suggestion motivates cross-species research to determine which species are capable of human-like beat perception, i.e., beat perception that involves accurate temporal prediction of beat times across a fairly broad range of tempi.
Psychological and psychophysiological effects of auditory and visual stimuli during various modes of exercise

This research programme had three principal objectives. First, to assess the stability of the exercise heart rate-music tempo preference relationship and its relevance to a range of psychological outcomes. Second, to explore the influence of two personal factors (motivational orientation and dominant attentional style) in a naturalistic exercise-to-music setting. Third, to examine means by which to enhance the exercise experience above and below the ventilatory threshold. In Study 1, a mixed-methods approach was employed to capture responses to differing music tempo conditions across a range of exercise intensities. Results in Study 1 did not support a cubic relationship (Karageorghis et al., 2011) but rather a quadratic one, and there was a weak association between the optimal choice of music tempo and positive psychological outcomes. Music conditions reduced the number of associative thoughts by ~10% across all exercise intensities. Study 2 employed questionnaires with a large sample of female participants (n = 417) attending exercise-to-music classes. Results indicate that motivational orientation and attentional style (Association vs. Dissociation) influence responses to an exercise-to-music class. Study 3 examined the effects of external stimuli (music and video) on psychological variables at moderate and high exercise intensities. Findings served to demonstrate that manipulations of attentional focus can have a salient influence on affect and enjoyment even during high-intensity exercise. The contributions of the research programme include providing empirical evidence that attention can be manipulated during high-intensity exercise using theoretically-guided music selections, and music in combination with video footage, which enhance the exercise experience. Further, the research programme advances understanding of how motivational orientation and attentional style influence responses to music during exercise.
Global Taxonomic Diversity of Living Reptiles

Reptiles are one of the most ecologically and evolutionarily remarkable groups of living organisms, having successfully colonized most of the planet, including the oceans and some of the harshest and more environmentally unstable ecosystems on earth. Here, based on a complete dataset of all the world’s diversity of living reptiles, we analyse lineage taxonomic richness both within and among clades, at different levels of the phylogenetic hierarchy. We also analyse the historical tendencies in the descriptions of new reptile species from Linnaeus to March 2012. Although (non-avian) reptiles are the second most species-rich group of amniotes after birds, most of their diversity (96.3%) is concentrated in squamates (59% lizards, 35% snakes, and 2% amphisbaenians). In strong contrast, turtles (3.4%), crocodilians (0.3%), and tuataras (0.01%) are far less diverse. In terms of species discoveries, most turtles and crocodilians were described early, while descriptions of lizards, snakes and amphisbaenians are multimodal with respect to time. Lizard descriptions, in particular, have reached unprecedented levels during the last decade. Finally, despite such remarkably asymmetric distributions of reptile taxonomic diversity among groups, we found that the distributions of lineage richness are consistently right-skewed, with most clades (monophyletic families and genera) containing few lineages (monophyletic genera and species, respectively), while only a few have radiated greatly (notably the families Colubridae and Scincidae, and the lizard genera Anolis and Liolaemus). Therefore, such consistency in the frequency distribution of richness among clades and among phylogenetic levels suggests that the nature of reptile biodiversity is fundamentally fractal (i.e., it is scale invariant). We then compared current reptile diversity with the global reptile diversity and taxonomy known in 1980. Despite substantial differences in the taxonomies (relative to 2012), the patterns of lineage richness remain qualitatively identical, hence reinforcing our conclusions about the fractal nature of reptile biodiversity.
Improving belief propagation on graphs with cycles

In this letter, we propose two modifications to belief propagation (BP) decoding algorithm. The modifications are based on reducing the reliability of messages throughout the iteration process, and are particularly effective for short low-density parity-check codes, where the existence of cycles makes the original BP algorithm perform suboptimal. The proposed algorithms, referred to as "normalized BP" and "offset BP," reduce the absolute value of the outgoing log-likelihood ratio messages at variable nodes by using a multiplicative factor and an additive factor, respectively. Simulation results show that both algorithms perform more or less the same, and both outperform BP in error performance.
Cochlear Coordinates in Regard to Cochlear Implantation: A Clinically Individually Applicable 3 Dimensional CT-Based Method

Setting: Cochlear implant (CI)/tertiary referral center. Subjects: Twenty-five patients implanted with an Advanced Bionics HiRes90K HiFocus1J CI. Study Design/Main Outcome Measures: A 3-dimensional cylindrical coordinate system is introduced using the basal turn of the cochlea as the x and y planes and the center of the modiolus as the z axis. The 0-degree angle is defined by the most lateral point of the horizontal semicircular canal. It is applied to both preoperative and postoperative computed tomographies in 25 patients. The angular position of the round window is examined. Interobserver reproducibility is tested by localization of all electrode contacts within the coordinate system. To observe realignment over time, electrode coordinates in postoperative images were projected on preoperative images. Additionally, comparison to existing imaging-related coordinate systems was made. Results: The angular position of the center of the round window is 34.6 ± 0.4 degrees (standard deviation) with an intraclass coefficient of 1.00. The intraclass coefficient for interobserver reproducibility of the 16 electrode contacts ranged from 0.74 to 1 for the rotational angle (&phgr;) and 0.77 to 1 for the distance to the modiolus (&rgr;). In 21 of 25 patients, a perfect match or minimal displacement of up to 3 electrode contacts was seen. Comparison to existing systems showed good correlation. Conclusion: A 3-dimensional cochlear coordinate system easily applicable in clinical patients is described, which fulfills the requirements set by an international consensus.
Bilateral Free Trade Agreements and Customs Unions: The Impact of the EU Republic of South Africa Free Trade Agreement on Botswana

The EU has indicated that after 2008 its trade relationships with developing countries will be dominated by the development of preferential trade agreements. Although not a consequence of the Cotonou Agreement, the free trade agreement between the EU and the Republic of South Africa (EU RSA FTA) is clearly one of the first fruits of this approach to trade relationships. However, there is no evidence that the design of the EU RSA FTA incorporated a comprehensive general equilibrium evaluation of the agreement for either the signatories or the other southern African nations. The analyses reported here indicate that while the EU RSA FTA may substantially benefit the signatories, there are appreciable negative impacts for other states, especially the RSA’s immediate neighbours. Moreover, the reluctance of the EU to fully liberalise trade in food and agriculture commodities results in a major reduction in the benefits for the RSA without ameliorating substantively the adverse implications for other nations.
Overcoming Test Anxiety: Giving Students the Ability to Show What They Know.

This chapter outlines the concept of test anxiety and its impact on performance, manners in which to diagnose and provide accommodations for the disability, and many means by which to reduce the impact of test anxiety. Overall, it bears repeating that although the concept of test anxiety is relatively simple, understanding how it affects a given individual is complex and dependent on many factors. Despite its complexity, test anxiety is an important consideration as long as performance evaluations are valued as determinants for access to education, resources, and other opportunities. (Contains 33 references.) (GCP) Reproductions supplied by EDRS are the best that can be made from the original document. Overcoming Test Anxiety: Giving Students Show What They Know the Ability to