Miracle-dz/UniFAR-FTUs huggingface dataset:
Re-mediating Literacy: Culture, Difference, and Learning for Students From Nondominant Communities

this chapter, we examine notions of educational risk in the context of literacy theories and research. Deficit notions about the cognitive potential of individuals from nondominant1 communities have persisted in social science inquiry, particularly where literacy is concerned. The intellectual trails of current conflicting ideas about literacy can be traced in part to theories about the role of literacy in society. For example, the great divide theories of literacy, sustained by a view of culture as social evolution and progress (Cole, 2005), attributed significant differences to the cognitive and cultural development of literate and nonliterate people and their communities (Goody, 1977, 1986, 1987; Goody & Watt, 1963; Havelock, 1963; Ong, 1982). 2 This literacy thesis held that there were "categorical differences in cognition and language as consequences of literacy" (Reder & Davila, 2005, p. 171) differences marked by stark dualities used to characterize literate and nonliterate communities: writing versus orality, modern versus traditional, and educated versus uneducated, for example (Collins, 1995, p. 75). As Reder and Davila (2005) have noted, "literacy was presumed to have broad and ubiquitous consequences in such areas as: abstract versus context-dependent uses and genre of language; logical, critical, and scientific versus irrational modes of thought; analytical history versus myth; and so forth" (p. 171). These theories of literacy were challenged for their wideranging dichotomies that perpetuated the hierarchical differences between "types of societies, modes of thought, and uses of language" (p. 171) and reductive notions of culture and thought (Cole & Scribner, 1974, 1977).
Genomic Dynamics of Transposable Elements in the Western Clawed Frog (Silurana tropicalis)

Transposable elements (TEs) are repetitive DNA sequences that can make new copies of themselves that are inserted elsewhere in a host genome. The abundance and distributions of TEs vary considerably among phylogenetically diverse hosts. With the aim of exploring the basis of this variation, we evaluated correlations between several genomic variables and the presence of TEs and non-TE repeats in the complete genome sequence of the Western clawed frog (Silurana tropicalis). This analysis reveals patterns of TE insertion consistent with gene disruption but not with the insertional preference model. Analysis of non-TE repeats recovered unique features of their genome-wide distribution when compared with TE repeats, including no strong correlation with exons and a particularly strong negative correlation with GC content. We also collected polymorphism data from 25 TE insertion sites in 19 wild-caught S. tropicalis individuals. DNA transposon insertions were fixed at eight of nine sites and at a high frequency at one of nine, whereas insertions of long terminal repeat (LTR) and non-LTR retrotransposons were fixed at only 4 of 16 sites and at low frequency at 12 of 16. A maximum likelihood model failed to attribute these differences in insertion frequencies to variation in selection pressure on different classes of TE, opening the possibility that other phenomena such as variation in rates of replication or duration of residence in the genome could play a role. Taken together, these results identify factors that sculpt heterogeneity in TE distribution in S. tropicalis and illustrate that genomic dynamics differ markedly among TE classes and between TE and non-TE repeats.
Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes

Monte Carlo simulations of a mesoscale model of oligonucleosomes are analyzed to examine the role of dynamic-linker histone (LH) binding/unbinding in high monovalent salt with divalent ions, and to further interpret noted chromatin fiber softening by dynamic LH in monovalent salt conditions. We find that divalent ions produce a fiber stiffening effect that competes with, but does not overshadow, the dramatic softening triggered by dynamic-LH behavior. Indeed, we find that in typical in vivo conditions, dynamic-LH binding/unbinding reduces fiber stiffening dramatically (by a factor of almost 5, as measured by the elasticity modulus) compared with rigidly fixed LH, and also the force needed to initiate chromatin unfolding, making it consistent with those of molecular motors. Our data also show that, during unfolding, divalent ions together with LHs induce linker-DNA bending and DNA–DNA repulsion screening, which guarantee formation of heteromorphic superbeads-on-a-string structures that combine regions of loose and compact fiber independently of the characteristics of the LH–core bond. These structures might be important for gene regulation as they expose regions of the DNA selectively. Dynamic control of LH binding/unbinding, either globally or locally, in the presence of divalent ions, might constitute a mechanism for regulation of gene expression.
Fate of 125I-IGF-I Administered into the Amniotic Fluid of Late-Gestation Fetal Sheep

Large amounts of amniotic fluid (AF) are swallowed in late gestation. AF is the most accessible fetal compartment and provides a possible paraplacental route for the therapeutic administration of hormones and nutrients to the fetus. We therefore wished to investigate the fate of the predominant fetal growth factor, IGF-I, administered into AF of late-gestation ovine fetuses. Seven chronically catheterized fetuses at 124 d gestation had approximately 800 × 106 dpm of 125I-IGF-I injected into the AF. AF and blood samples were withdrawn for up to 6 d. At 131 d gestation a postmortem examination was performed. All AF, blood, and tissue samples were counted. Selected samples of AF, blood, and gut contents underwent size-separation chromatography. 125I-IGF-I was rapidly mixed in AF, with a significant difference in counts from different regions of the cavity persisting for only 3 h (p < 0.05). In vivo binding of 125I-IGF-I in AF correlated highly with AF IGF binding protein 3 concentrations (r2 = 0.93, p < 0.0001). In some animals, free 125I-IGF-I persisted in AF and in plasma for the duration of the experiments. Chromatography of plasma samples demonstrated that intact 125I-IGF-I was taken up from the fetal gut. Only fetal gut and thyroid contained appreciable counts at postmortem examination. Gut contents had more counts than gut wall, and the number of counts in gut contents increased distally (p < 0.05 for colon contents versus other regions). We conclude that there is sustained delivery of 125I-IGF-I from the AF to the gut and systemic circulation of the ovine fetus after a single intraamniotic injection.
Sequential Annotation and Chunking of Chinese Discourse Structure

We propose a linguistically driven approach to represent discourse relations in Chinese text as sequences. We observe that certain surface characteristics of Chinese texts, such as the order of clauses, are overt markers of discourse structures, yet existing annotation proposals adapted from formalism constructed for English do not fully incorporate these characteristics. We present an annotated resource consisting of 325 articles in the Chinese Treebank. In addition, using this annotation, we introduce a discourse chunker based on a cascade of classifiers and report 70% top-level discourse sense accuracy.
Multi channel high aspect ratio glass microelectrode array for neuroprosthetic applications

To map neural signal in the brain 3D electrodes are desired. 3D electrodes are difficult fabricate due to the cumbersome assembly process. In this work, 2D array of glass electrodes were designed and later assembles into 3D by simple assembly process. Glass was used as a dielectric material to provide better electrical isolation capability and better biocompatibility compared to silicon. Five shanks per 2D array were fabricated and each shank had 5 channels/active sites making it to be 25 channels per 2D array. Four 2D arrays were stacked and wire bonded to give 100 channels per 3D array.
Enzyme activity assay for cholesterol 27-hydroxylase in mitochondria Published, JLR Papers in Press, April 12, 2006.

Mitochondrial cholesterol 27-hydroxylase (CYP27A1) plays an important role in the maintenance of intracellular cholesterol homeostasis. Cholesterol delivery to the mitochondrial inner membrane is believed to be a rate-limiting step for the “acidic” pathway of bile acid synthesis. This work reports that proteinase K treatment of mitochondria markedly increases CYP27A1 specific activity. With endogenous mitochondrial cholesterol, treatment with proteinase K increased CYP27A1 specific activity by 5-fold. Moreover, the addition of the exogenous cholesterol in β-cyclodextrin plus proteinase K treatment increased the specific activity by 7-fold. Kinetic studies showed that the increased activity was time-, proteinase K-, and substrate concentration-dependent. Proteinase K treatment decreased the apparent Km of CYP27A1 for cholesterol from 400 to 150 μM. Using this new assay, we found that during rat hepatocyte preparation and cell culture, mitochondria gradually lose CYP27A1 activity compared with mitochondria freshly isolated from rat liver tissue.
Consumer motivations in taking action against spyware: an empirical investigation

Purpose – The purpose of this paper is to develop a research framework and empirically analyze the factors that motivate the consumers to adopt and use anti‐spyware tools when they are faced with security threats.Design/methodology/approach – The research model was tested with data obtained through online survey questionnaires. A pre‐ and a pilot‐test of the survey instrument are conducted. Then, a final five‐point Likert scale instrument is created. The solicitation for participants is done through e‐mail invitations. Survey results are analyzed using factor analysis and logistic regression.Findings – The results do not find statistically significant relationships for hypotheses related to perceived vulnerability and response cost with the dependent variable. Perceived severity, self‐efficacy, and response efficacy are significantly related to use of anti‐spyware tools.Research limitations/implications – The empirical findings suggest that protection motivation theory (PMT) may possibly provide a new ave.
Perilaku Kepemimpinan Berorientasi Hubungan Dan Tugas Sebagai Anteseden Komitmen Organisasional, Self-Efficacy Dan Organizational Citizenship Behavior (OCB)

This study is aimed at analyzing the influence of the worker perception about the leadership behavior which is relationship-oriented and task-oriented from the leader or the supervisor towards the work through organizational commitment and self-efficacy. The results of the research show: 1) the tendency of the leaders in applying leadership behaviour with relationship-oriented and task-oriented is high, and so are the self-efficacy, organizational commitment, and extra-role (OCB) workship (either the employee or the employer). 2) The influence of leadership behaviour with relationship-oriented and task-oriented towards extra role (OCB) workship is not significant. The correlations among those variables undergo changes after they were intefered by self-efficacy and organizational variable as the moderator variable. 3) The result of this research shows that self-efficacy variable mediates the influence of leadership behaviour with relationship-oriented towards extra-role workship (OCB), rather than mediates leadership behaviour with task-oriented. While, the organizational commitment mediates leadership behaviour with task-oriented towards extra-role (OCB) workship, rather than mediates leadership behaviour with task-oriented towards the employee of OCB.
Differences between objective and subjective sleep measures in children with attention deficit hyperactivity disorder.

STUDY OBJECTIVES To assess sleep characteristics in children with ADHD through polysomnographic recordings and parental reports of sleep problems. METHODS Standard overnight polysomnography evaluation was performed to record sleep in 27 children with ADHD and 26 healthy controls, aged 7 to 12 years. The diagnosis of ADHD was determined by the Korean version of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL-K). Children taking any medications or in poor health were excluded. All the subjects were assessed with the Children's Sleep Habits Questionnaire which was completed by parents. Overall neurobehavioral functioning was examined using various questionnaires, including the Child Behavioral Checklist (CBCL). RESULTS Based on the findings from the questionnaire, the ADHD group had significantly higher scores on the sleep onset delay (p = 0.027), sleep duration (p = 0.032), night waking (p = 0.006), parasomnias (p = 0.016), daytime sleepiness (p = 0.007), and total sleep disturbance factors (p < 0.001) than children in the control group. However, there were no differences between ADHD and healthy groups on any polysomnographic variables, including sleep structure, arousals, and respiratory disturbances. Reported sleep problems were significantly associated with almost all subscales of CBCL as well as CBCL total score. CONCLUSIONS The majority of sleep problems reported by the parents of ADHD children were not verified through the use of polysomnography. These findings raise the possibility that some of the reported sleep problems in ADHD may be related to disturbing behaviors which often characterize children with ADHD.
[A quantitative assay for JAK2 mutation in 135 patients with chronic myeloproliferative neoplasms].

OBJECTIVE To investigate the frequency and mutational status of JAK2 mutation in Chinese patients with chronic myeloproliferative neoplasms (MPN) and study the relative quantitation and clinical implications of mutated JAK2 transcript. METHODS JAK2 mutation and the mutational status were screened with amplification-refractory mutation sequencing polymerase chain reaction (ARMS-PCR), the relative quantity of mutated JAK2 mRNA by using capillary electrophoresis. RESULTS JAK2V617F mutation was detected in 95 of 135 MPN patients, including 37 (97.4%) of 38 polycythemia vera (PV), 56 (59.6%) of 94 essential thrombocythemia (ET) and 2 of 3 idiopathic myelofibrosis (IMF) patients; the difference between the mutations in PV and ET was significant (P<0.05). Of 95 JAK2V617F patients examined, 18/38 PV patients (47.3%) and 17/94 (18.1%) ET patients and 1 IMF patient were homozygotes, and ET patients showed lower prevalence of homozygote (P<0.05). In 95 MPN patients, the mutated mRNA ratio was higher in homozygote than in heterozygote patients. PV heterozygote patients showed higher levels of mutated JAK2 mRNA than ET heterozygote patients (P<0.05). The levels of JAK2V617F mRNA in patients over 60 years of age were significantly higher than that in those less than 60 years of age (P<0.001). Higher leukocyte counts were observed in PV and ET patients with higher levels of mutated JAK2 mRNA (P<0.05). The presence of JAK2V617F was found to be significantly associated with higher hemoglobin level in ET patients. Cytogenetic analysis was performed in 101 of the 135 patients, the association between abnormal karyotype and JAK2V617F was not found. CONCLUSION The ARMS-PCR technique can be used to detect the frequency and mutational status of JAK2V617F mutation, and along with capillary electrophoresis, the estimation of minimal residual disease becomes possible.
Variation in Incidence and Fatality of Melanoma by Season of Diagnosis in New South Wales, Australia

Seasonal variation in cutaneous melanoma incidence with a summer peak is poorly understood. It has been hypothesized to be due to increased diagnosis in summer or a late-promoting effect of sun exposure. We analyzed the characteristics of incident cases of cutaneous melanoma and their outcome by season of diagnosis in the population of New South Wales, Australia. Cases of melanoma (25,845 cases; 10,869 females and 14,976 males) were registered by the New South Wales Central Cancer Registry in 1989 to 1998. There was significant seasonal variation in incidence (P < 0.0001, Nam test). The summer to winter ratio was greater for women, younger people, lesions on the limbs, and superficial spreading melanoma. Melanomas were thicker in winter than in summer (medians 0.75 and 0.70 mm, respectively; P < 0.0001, Kruskal-Wallis test). Cases were followed for a median of 63 months and 2,710 (10.5%) died from their melanoma. Fatality from melanoma was lower for melanomas diagnosed in summer than winter (relative fatality = 0.72; 95% confidence interval, 0.65-0.81); the 5-year survival rate was 92.1% for diagnosis in summer and 89.0% for diagnosis in winter. This result remained significant after adjustment for year of diagnosis, age, sex, Breslow thickness, anatomic location, and histologic type (relative fatality = 0.82; 95% confidence interval, 0.72-0.94). Seasonality in melanoma incidence is probably caused mainly by increased and earlier diagnosis in summer, although a late-stage promotional effect of sun exposure cannot be excluded completely. Earlier diagnosis may also reduce fatality when melanoma is diagnosed in summer. Independence of variation in fatality with season from seasonal variation in thickness, however, suggests that sun exposure around the time of diagnosis decreases fatality of melanoma. (Cancer Epidemiol Biomarkers Prev 2006;15(3):524–8)
The contribution of perceived fit between job demands and abilities to teachers’ commitment and job satisfaction

The current study aims at exploring the common means that may improve organizational effectiveness by focusing on two main facets of organizational qualities: teacher commitment and job satisfaction. Data were collected from 841 randomly sampled teachers employed in 118 elementary schools in Israel. A quantitative questionnaire, which included scales measuring organizational and professional commitment, extrinsic and intrinsic satisfaction and organizational and job-related characteristics, was employed. Multiple regression analyses revealed that the single variable that predicted both types of commitment (organizational and professional) and both types of satisfaction (intrinsic and extrinsic) was teachers’ perceptions of the fit between one's job demands and abilities. The second most influential predictor was principals’ interaction with the teachers. Job-related characteristics had the least impact on teacher’s professional commitment and extrinsic satisfaction. The finding, that perceived job fit predicted both commitment and job satisfaction, reinforces the importance of the assumption about the significance of best practice in recruitment and placement processes, which has long been known to be significant in determining professional conduct. Other implications of the findings are discussed, and recommendations are provided to school principals.
Memantine Monotherapy for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Background We performed an updated meta-analysis of randomized placebo-controlled trials testing memantine monotherapy for patients with Alzheimer’s disease (AD). Methods The meta-analysis included randomized controlled trials of memantine monotherapy for AD, omitting those in which patients were also administered a cholinesterase inhibitor. Cognitive function, activities of daily living, behavioral disturbances, global function, stage of dementia, drug discontinuation rate, and individual side effects were compared between memantine monotherapy and placebo groups. The primary outcomes were cognitive function and behavioral disturbances; the others were secondary outcomes. Results Nine studies including 2433 patients that met the study’s inclusion criteria were identified. Memantine monotherapy significantly improved cognitive function [standardized mean difference (SMD)=−0.27, 95% confidence interval (CI)=−0.39 to −0.14, p=0.0001], behavioral disturbances (SMD=−0.12, 95% CI=−0.22 to −0.01, p=0.03), activities of daily living (SMD=−0.09, 95% CI=−0.19 to −0.00, p=0.05), global function assessment (SMD=−0.18, 95% CI=−0.27 to −0.09, p=0.0001), and stage of dementia (SMD=−0.23, 95% CI=−0.33 to −0.12, p=0.0001) scores. Memantine was superior to placebo in terms of discontinuation because of inefficacy [risk ratio (RR)=0.36, 95% CI=0.17¬ to 0.74, p=0.006, number needed to harm (NNH)=non significant]. Moreover, memantine was associated with less agitation compared with placebo (RR=0.68, 95% CI=0.49 to 0.94, p=0.02, NNH=non significant). There were no significant differences in the rate of discontinuation because of all causes, all adverse events, and individual side effects other than agitation between the memantine monotherapy and placebo groups. Conclusions Memantine monotherapy improved cognition, behavior, activities of daily living, global function, and stage of dementia and was well-tolerated by AD patients. However, the effect size in terms of efficacy outcomes was small and thus there is limited evidence of clinical benefit.
A Comparison of Entrepreneurs and Managers of Small Business Firms

This study explores the relationship between entrepreneurship and small business management. Business founders are classified as entrepreneurs and nonfounding chief executives are classified as small business managers. Findings indicate that (a) on personal and firm characteristics, eight variables differentiate the groups; (b) onfinancial performance indicators, entrepreneurial firms show higher growth rates; and (c) hard-driving competitiveness consistently associates with financial performance for small business managers but not for entrepreneurs. Data come from questionnaires completed by members of the Smaller Business Association of New England.
Can Parental Support Mediate the Link between Low Self‐Control and Deviance?

Drawing on self‐report survey data from a sample of 425 college students in 2001, this study examines whether parental support can mediate the link that low self‐control has with deviance. Using multiple measures of low self‐control and parental support and item parcels of deviance, structural equation models are developed to arrive at the results. Results reveal that parental support does not completely mediate the link between low self‐control and deviance. Importantly, we find that parental support can reduce the link that low self‐control has with deviance, suggesting that this is a measure that may be manipulated to reduce instances of deviance.