Miracle-dz/UniFAR-FTUs huggingface dataset:
Plenary Lecture 3 Food and the planet: nutritional dilemmas of greenhouse gas emission reductions through reduced intakes of meat and dairy foods

Legally-binding legislation is now in place to ensure major reductions in greenhouse gas emissions in the UK. Reductions in intakes of meat and dairy products, which account for approximately 40% of food-related emissions, are an inevitable policy option. The present paper assesses, as far as is possible, the risk to nutritional status of such a policy in the context of the part played by these foods in overall health and well-being and their contribution to nutritional status for the major nutrients that they supply. Although meat may contribute to saturated fat intakes and a higher BMI, moderate meat consumption within generally-healthy population groups has no measurable influence on morbidity or mortality. However, high consumption of red and processed meat has been associated with increased risk of colo-rectal cancer and recent advice is to reduce intakes to a maximum of 70 g/d. Such reductions in meat and haem-Fe intake are unlikely to influence Fe status in functional terms. However, overall protein intakes would probably fall, with the potential for intakes to be less than current requirements for the elderly. Whether it is detrimental to health is uncertain and controversial. Zn intakes are also likely to fall, raising questions about child growth that are currently unanswerable. Milk and dairy products, currently specifically recommended for young children and pregnant women, provide 30–40% of dietary Ca, iodine, vitamin B12 and riboflavin. Population groups with low milk intakes generally show low intakes and poor status for each of these nutrients. Taken together it would appear that the reductions in meat and dairy foods, which are necessary to limit environmental damage, do pose serious nutritional challenges for some key nutrients. These challenges can be met, however, by improved public health advice on alternative dietary sources and by increasing food fortification.
Comparison of Oral Health Education and Fluoride Varnish to Prevent Early Childhood Caries: A Randomized Clinical Trial

Early childhood caries, a serious health problem among young children, can be prevented with effective intervention. The aim of this study was to evaluate the efficacy of oral health education and a fluoride varnish in the prevention of caries in children under the age of 3 years. For this single-blind randomized parallel group 1-year clinical trial in Shiraz, 300 children aged 12-24 months with sound primary teeth were selected and randomly divided into three groups (n = 100): (1) control: no preventive intervention; (2) oral health counseling, and (3) oral health counseling and fluoride varnish at baseline and 6 months later. At baseline and 4, 8 and 12 months after the intervention, caries risk reduction was recorded as the primary outcome. The mothers' knowledge and performance regarding oral health in children was used as a secondary outcome. A total of 260 children (mean age: 20.49 ± 7.33 months) completed the study. Compared to group 1, caries risk reduction in group 2 was 28% (95% CI: -39.05 to -17.45) and 31% in group 3 (95% CI: -41.88 to -21.73). However, there was no significant difference between groups 2 and 3 (95% CI: -8.58 to 1.47). In all groups, mothers' knowledge and performance at baseline were low; however, they increased significantly in follow-up appointments in groups 2 and 3 (p < 0.001). Oral health education increased mothers' knowledge and performance regarding oral health in children. Oral health counseling alone or associated with the use of fluoride varnish reduced the caries incidence in young children.
Effectiveness of kinesio-taping on pain and functional disability on non-specific low back pain-a randomized clinical trial.

Introduction: Non-specific low back pain is defined as pain not attributable to a recognizable or known specific pathology. Non-specific low back pain is characterized by the absence of structural change. The most frequent site of low back pain is in the 4th and 5th lumbar segment. Chronic low back pain constitutes one of the greatest factors limiting activity in adults under the age of 45. Methods and Materials: 30 patients (15 in each group), both males and females weretaken. Informed consent were signed by the patients and patients were divided into two groups by random number table, Group A and Group B. Patients were assessed at 0 day before giving treatment and follow up of patients were done on 2nd week and 4th week after completing the treatment. Group A patients were receiving conventional physiotherapy including of moist heat therapy and spinal strengthening (lumbar loading) exercises. Treatment was given for 5 times a week for 4 weeks. Group B patients were receiving kinesio taping plus conventional physiotherapy. Kinesio tape wasapplied twice a week for 4 weeks for a total of 8 sessions. VAS (Visual Analog Scale), RMQ (Roland Morris Disability Questionnaire) and ROM (Range Of Motion) were checked. Discussion& Conclusion:There was no significant difference at 2nd week as compared to 0 week (p>0.001 or p>0.05) of VAS, RMQ, ROM (Flexion), but there was a significant difference at 4th week (p<0.001 or p<0.05) as compared to both 0 week and 2nd week. Therefore, it seems that the Kinesio-taping plus conventional physiotherapy are more beneficial than conventional physiotherapy alone when treating nonspecific low back pain patients
Assessment of recombinant bovine somatotropin as an immunomodulator during avian coccidiosis: immunization with living oocysts.

Coccidiosis, a disease of great economic importance to the poultry industry, is generally controlled prophylactically by additions of anticoccidial drugs to the feed. However, increasing development of drug-resistant coccidia species has stimulated searches for alternative control methods, one of which is vaccination. As part of this effort, recombinant bovine growth hormone (rbST) was tested as a possible immune stimulator in combination with live oocyst vaccination. At a dose of 0.045 mg per chick, given by s.c. injection at 1 d of age, rbST did not improve immunity developed by immunization with 500 or 2,500 oocysts of Eimeria maxima as judged by weight gain and lesion scores. At a single dose of 0.09 mg per chick given at 1 d of age in combination with IMMUCOX, rbST provided some protection against challenge infection with Eimeria tenella but not Eimeria acervulina as judged by reduction in lesion scores. Treatment with 0.09 mg rbST per chick alone at 1 and 3 d of age was protective against challenge with E. tenella but not E. acervulina or E. maxima as judged by reduction in lesion scores. These results strongly indicate that rbST can act as an immune modulator in chickens infected with coccidia, and provide a basis for further investigations of its use as a vaccine adjuvant.
Role of palliative resection of the primary pancreatic neuroendocrine tumor in patients with unresectable metastatic liver disease: a systematic review and meta-analysis

Background Treatment for pancreatic neuroendocrine tumors (PNETs) in patients with unresectable metastatic liver disease has long been a controversial issue. This systematic review aims to summarize the existing evidence concerning the value of primary tumor resection in this group of patients. Methods A systematic review of the literature and a meta-analysis were performed. The PubMed and Cochrane databases were searched to identify articles that compared palliative primary tumor resection and nonsurgical regimens in patients with PNETs and unresectable liver metastases. Relevant articles were identified in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary outcome was overall survival. The included studies were evaluated for heterogeneity and publication bias. Results Overall, 10 studies were included in the analysis. No randomized controlled trials (RCTs) were identified. These studies included 1,226 patients who underwent a resection of the primary tumor and 1,623 patients who did not undergo surgery. The median overall survival was 36–137 and 13.2–65 months in the surgical and nonsurgical groups, respectively, and the 5-year overall survival rate was 35.7–83 and 5.4%–50%, respectively, in these two groups. The meta-analysis demonstrated that there was no significant difference in liver tumor burden (odds ratio [OR] =1.51, 95% CI: 0.59–3.89, P=0.39) or tumor grade (OR =2.88, 95% CI: 0.92–9.04, P=0.07) among patients who underwent surgery and nonsurgical therapy. Furthermore, patients who underwent an aggressive surgical approach appeared to have a higher tumor grade. However, the meta-analysis demonstrated that patients who underwent primary tumor resection had better overall survival (P<0.001), with a pooled hazard ratio of 0.36 (95% CI: 0.30–0.45). No publication bias was detected. Conclusion This meta-analysis demonstrates that the palliative resection of the primary tumor in patients with PNETs and unresectable liver metastases can increase survival, although a bias toward a more aggressive surgical approach in patients with better performance status, less advanced disease, or a tumor located in the body or tail of the pancreas appears likely. RCTs with longer follow-up periods are required to confirm the advantages of palliative primary tumor resection for PNETs.
Chance Constrained Selection of the Best

Selecting the solution with the largest or smallest mean of a primary performance measure from a finite set of solutions while requiring secondary performance measures to satisfy certain constraints is called constrained selection of the best CSB in the simulation ranking and selection literature. In this paper, we consider CSB problems with secondary performance measures that must satisfy probabilistic constraints, and we call such problems chance constrained selection of the best CCSB. We design procedures that first check the feasibility of all solutions and then select the best among all the sample feasible solutions. We prove the statistical validity of these procedures for variations of the CCSB problem under the indifference-zone formulation. Numerical results show that the proposed procedures can efficiently handle CCSB problems with up to 100 solutions, each with five chance constraints.
Sentential negation in early child English1

Starting with the seminal work of Klima & Bellugi (1966) and Bellugi (1967), young English-speaking children have been observed to pass through a stage at which their negative utterances differ from those of adults. Children initially use not or no, whereas adults use negative auxiliary verbs (don't, can't, etc.). To explain the observed mismatches between child and adult language, the present study adopts Zeijlstra's (2004, 2007, 2008a, b) Negative Concord Parameter, which divides languages according to whether they interpret negation directly in the semantics with an adverb, or license it in the syntactic component, in which case the negative marker is a head and the language is a negative concord language. Our proposal is that children first hypothesize that negation is expressed with an adverb, in keeping with the more economical parameter value. Because English is exceptional in having both an adverb and a head form of negation, children must also add a negative head (i.e. n't) to their grammar. This takes considerable time as the positive input that triggers syntactic negation and negative concord is absent in the input for standard English, and children must find alternative evidence. The Negative Concord Parameter accounts for an intricate longitudinal pattern of development in child English, as non-adult structures are eliminated and a new range of structures are licensed by the grammar.
Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity

The correlations between irisin levels, physical activity, and anthropometric measurements have been extensively described in adults with considerable controversy, but little evidence about these relationships has been found in children. The objective of this study is to correlate the plasma levels of irisin in underweight, normal weight, overweight, and obese children with anthropometric parameters and physical activity levels. A cross-sample of 40 children was divided into the following groups on the basis of body mass index (BMI) percentile. The correlations of plasma irisin levels with physical activity, anthropometric, and metabolic measurements were determined. Plasma irisin levels (ng/mL) were lower for the underweight group (164.2 ± 5.95) than for the normal weight and obese groups (182.8 ± 5.58; p < 0.05). Irisin levels correlated positively with BMI percentile (0.387), waist circumference (0.373), and fat-free mass (0.353; p < 0.05), but not with body muscle mass (−0.027). After a multiple linear regression analysis, only BMI percentile (0.564; p < 0.008) showed a positive correlation with irisin. Our results indicated no association with metabolic parameters. A negative correlation with physical activity was observed. Interrelationships among body components might influence irisin levels in children.
Dietary polyunsaturated fatty acids alter lymphocyte subset proportion and proliferation, serum immunoglobulin G concentration, and immune tissue development in chicks.

The effects of fat source on immune response of the offspring of the Single Comb White Leghorn laying hens were investigated. The laying hens were fed for 6 wk with a wheat-soybean meal basal diet with added sunflower oil (SO), animal oil (AO), linseed oil (LO), or menhaden fish oil (FO) at 5% (wt/wt). Upon hatching, the chicks (30/group) were given the same types of diets for 8 wk. The dietary SO, AO, and LO provided different n-6 to n-3 polyunsaturated fatty acids (PUFA) ratios. The FO and LO had ratios of n-6 to n-3 PUFA that were close but had different components of n-3 PUFA. The results demonstrated that the chicks fed LO or FO had significantly lower (P < 0.05) splenocyte proliferative response to ConA than the chicks fed SO or AO at either 4 wk or 8 wk of age, with a stronger (P < 0.05) suppressive effect produced by LO at 4 wk. A significantly lower (P < 0.05) splenocyte response to PWM was produced by the chicks fed AO, LO, and FO compared with the chicks fed SO at 8 wk. The thymus lymphocyte proliferation in response to ConA at 4 wk was lower (P < 0.05) in the chicks fed AO, LO, and FO than in the chicks fed SO. Both LO and FO elevated (P < 0.05) the proportion of IgM+ lymphocytes in spleen, but only FO increased (P < 0.05) the serum IgG concentration. The LO elevated (P < 0.05) the percentage of CD8+ T-lymphocytes but not the ratio of CD4+ to CD8+ cells (P > 0.05) in spleen. Growths of thymus, spleen, and bursa were impacted significantly (P < 0.05) by the amount of dietary PUFA, the ratio of n-6 to n-3 fatty acids, and n-3 PUFA components.
Enabling the Adoption of Processing-in-Memory: Challenges, Mechanisms, Future Research Directions

Poor DRAM technology scaling over the course of many years has caused DRAM-based main memory to increasingly become a larger system bottleneck. A major reason for the bottleneck is that data stored within DRAM must be moved across a pin-limited memory channel to the CPU before any computation can take place. This requires a high latency and energy overhead, and the data often cannot benefit from caching in the CPU, making it difficult to amortize the overhead. Modern 3D-stacked DRAM architectures include a logic layer, where compute logic can be integrated underneath multiple layers of DRAM cell arrays within the same chip. Architects can take advantage of the logic layer to perform processing-in-memory (PIM), or near-data processing. In a PIM architecture, the logic layer within DRAM has access to the high internal bandwidth available within 3D-stacked DRAM (which is much greater than the bandwidth available between DRAM and the CPU). Thus, PIM architectures can effectively free up valuable memory channel bandwidth while reducing system energy consumption. A number of important issues arise when we add compute logic to DRAM. In particular, the logic does not have low-latency access to common CPU structures that are essential for modern application execution, such as the virtual memory and cache coherence mechanisms. To ease the widespread adoption of PIM, we ideally would like to maintain traditional virtual memory abstractions and the shared memory programming model. This requires efficient mechanisms that can provide logic in DRAM with access to CPU structures without having to communicate frequently with the CPU. To this end, we propose and evaluate two general-purpose solutions that minimize unnecessary off-chip communication for PIM architectures. We show that both mechanisms improve the performance and energy consumption of many important memory-intensive applications.
Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications

The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes. A large body of evidence support that among the various components of the PA system, urokinase-type plasminogen activator (uPA), its receptor (uPAR), and plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) play a major role in tumor progression and metastasis. The binding of uPA with uPAR is instrumental for the activation of plasminogen to plasmin, which in turn initiates a series of proteolytic cascade to degrade the components of the extracellular matrix, and thereby, cause tumor cell migration from the primary site of origin to a distant secondary organ. The components of the PA system show altered expression patterns in several common malignancies, which have identified them as ideal diagnostic, prognostic, and therapeutic targets to reduce cancer-associated morbidity and mortality. This review summarizes the various components of the PA system and focuses on the role of uPA–uPAR in different biological processes especially in the context of malignancy. We also discuss the current state of knowledge of uPA–uPAR-targeted diagnostic and therapeutic strategies for various malignancies.
The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats

The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted. For that reason, the procognitive effects of the H3R antagonist DL77 on cognitive impairments induced with MK801 were tested in an inhibitory passive avoidance paradigm (PAP) and novel object recognition (NOR) task in adult male rats, using donepezil (DOZ) as a standard drug. Acute systemic pretreatment with DL77 (2.5, 5, and 10 mg/kg, i.p.) significantly ameliorated memory deficits induced with MK801 in PAP (all P < 0.05, n = 7). The ameliorative effect of most promising dose of DL77 (5 mg/kg, i.p.) was reversed when rats were co-injected with the H3R agonist R-(α)-methylhistamine (RAMH, 10 mg/kg, i.p.) (p = 0.701 for MK801-amnesic group vs. MK801+DL77+RAMH group, n = 6). In the NOR paradigm, DL77 (5 mg/kg, i.p.) counteracted long-term memory (LTM) deficits induced with MK801 (P < 0.05, n = 6–8), and the DL77-provided effect was similar to that of DOZ (p = 0.788, n = 6–8), and was reversed when rats were co-injected with RAMH (10 mg/kg, i.p.) (p = 0.877, n = 6, as compared to the (MK801)-amnesic group). However, DL77 (5 mg/kg, i.p.) did not alter short-term memory (STM) impairment in NOR test (p = 0.772, n = 6–8, as compared to (MK801)-amnesic group). Moreover, DL77 (5 mg/kg) failed to modify anxiety and locomotor behaviors of animals innate to elevated-plus maze (EPM) (p = 0.67 for percentage of time spent exploring the open arms, p = 0.52 for number of entries into the open arms, p = 0.76 for percentage of entries into the open arms, and p = 0.73 number of closed arm entries as compared to saline-treated groups, all n = 6), demonstrating that the procognitive effects observed in PAP or NOR tests were unconnected to alterations in emotions or in natural locomotion of tested animals. These results signify the potential involvement of H3Rs in modulating neurotransmitters related to neurodegenerative disorders, e.g., AD.
High‐salt diet induces outward remodelling of efferent arterioles in mice with reduced renal mass

The glomerular filtration rate (GFR) falls progressively in chronic kidney disease (CKD) which is caused by a reduction in the number of functional nephrons. The dysfunctional nephron exhibits a lower glomerular capillary pressure that is induced by an unbalance between afferent and efferent arteriole. Therefore, we tested the hypothesis that oxidative stress induced by CKD differentially impairs the structure or function of efferent vs. afferent arterioles.
EFFECT OF THE SOURCE AND RATE OF HUMIC ACID ON PHOSPHORUS TRANSFORMATIONS

An incubation experiment was carried out in vitro to monitor changes in bicarbonate extractable phosphate, resulting from the addition of applied-P (SSP) reinforced with both Farm Yard Manure (humic acid basis) and humic acid (lignitic coal). A calcareous soil was incubated with SSP (60 kg ha -1 ) alone and in different combinations with Farm Yard Manure (FYM) and humic acid (200, 400, 800, 1600 and 2000gms ha -1 ). Addition of FYM could not help in the mineralization of applied-P. The non significant effect of Farm Yard Manure on P-mineralization suggests that FYM recommendations on the basis of humic acid content do not fulfill the actual humic acid requirements. Therefore, further work is needed to incorporate additional parameters to fulfill the actual humic acid requirements. Humic acid (lignitic coal) applied @ 200g ha -1 showed least P-immobilization both from native and applied-P pool during 16 week of incubation. Percent P recovery and mineralized-P was also greater in humic acid @ 200g ha -1 soil.
Lysine, methionine and glycine requirements of Japanese quail to five weeks of age.

Abstract INTRODUCTION FEW studies of the amino acid requirements of Japanese quail have been reported. Donaldson (1967) found the requirements for the total sulfur amino acid to be 0.78% in a practical diet containing 25% protein, the glycine requirement to be 1.28% in a purified diet containing 29% protein, and the lysine requirement was met at 1.35% of a practical diet containing 25% protein. Amino acid requirements of Bobwhite quail and Ringneck pheasants, members of the same family as Coturnix, have been reported; Baldini et al. (1953) suggested a lysine requirement for young Bobwhite quail of 1.3% of the diet when the protein level was 20–24%. Scott et al. (1963) showed the total sulfur amino acid requirements of Bobwhite quail and Ringneck pheasants to be 3.66% of the protein in a practical corn-soybean meal diet. Scott and Reynolds (1949) found in studies with pheasant chicks that the glycine requirement was…