Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparisons of short-term efficacy between individual and group cognitive behavioral therapy for primary insomnia

The purpose of this study was to compare the efficacy of individual and group cognitive behavioral therapy for insomnia (CBT-I) in outpatients with primary insomnia diagnosed by DSM-IV-TR. The participants were 20 individually treated (I-CBT-I) and 25 treated in a group therapy format (three to five patients per group) (G-CBT-I), which showed no significant difference regarding demographic variables between groups. The same components of CBT-I stimulus control therapy, sleep restriction therapy, cognitive therapy, and sleep hygiene education were applied on both groups. The shortterm outcome (4 weeks after treatment) was measured by sleep logs, actigraphy, the Pittsburgh Sleep Quality Index (PSQI), and the Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS), and was compared between I-CBT-I and G-CBT-I. The results indicated that CBT-I was effective in improving subjective and objective sleep parameters and subjective sleep evaluations for both individual and group treatment. However, I-CBT-I resulted in significantly better improvements over G-CBT-I, in (i) objective and subjective sleep onset latency time, (ii) objective sleep efficacy and moving time during sleeping, (iii) overall sleep quality and duration of actual sleep time in PSQI, (iv) consequences of insomnia, control and predictability of sleep, sleep requirement expectation, and sleep-promoting practices in DBAS. The present study suggested the superiority of I-CBT-I over G-CBT-I in clinical settings, and further evaluations are necessary.
The De-standardisation of Early Family Trajectories in the Czech Republic: A Cross-cohort Comparison

Drawing upon the trajectory-based (holistic) approach, this article compares early family trajectories observed during the socialist period with those after the transition to a market economy in the Czech Republic. It aims (1) to provide an empirical analysis of change in the heterogeneity of early family trajectories between the ages of 18 and 35 and (2) to identify their distinct patterns. To do this an entropy index and optimal matching analysis is applied. The paper uses data from the ISSP 2002, which included questions on partnership and family history in the Czech Republic. The findings show that the process of de-standardisation is quite complex and non-uniform. Cohorts born from the 1970s on experience more diverse early family trajectories than older cohorts, mainly due to increasing unmarried cohabitation. However, in the cohort born in the 1980s we can observe a reversal trend of declining diversity of family statuses in the subjects' early twenties due to the postponement of family related transitions. Even among older birth cohorts, who experienced their family starts under the socialist regime, it is possible to find a certain plurality of family starts, differentiated by the level of education.
Mutation in Cyclophilin B That Causes Hyperelastosis Cutis in American Quarter Horse Does Not Affect Peptidylprolyl cis-trans Isomerase Activity but Shows Altered Cyclophilin B-Protein Interactions and Affects Collagen Folding*

Background: Hyperelastosis cutis in horses is caused by a homozygous mutation in cyclophilin B (PPIB). Results: This mutation changes protein-protein interactions of CypB and delays folding of collagen. Conclusion: Mutant CypB has PPIase activity, but the synthesized collagen contains less post-translational modifications of lysine residues. Significance: CypB has other important functions besides its PPIase activity. The formation of these interactions is crucial for a correct biosynthesis of collagen. The rate-limiting step of folding of the collagen triple helix is catalyzed by cyclophilin B (CypB). The G6R mutation in cyclophilin B found in the American Quarter Horse leads to autosomal recessive hyperelastosis cutis, also known as hereditary equine regional dermal asthenia. The mutant protein shows small structural changes in the region of the mutation at the side opposite the catalytic domain of CypB. The peptidylprolyl cis-trans isomerase activity of the mutant CypB is normal when analyzed in vitro. However, the biosynthesis of type I collagen in affected horse fibroblasts shows a delay in folding and secretion and a decrease in hydroxylysine and glucosyl-galactosyl hydroxylysine. This leads to changes in the structure of collagen fibrils in tendon, similar to those observed in P3H1 null mice. In contrast to cyclophilin B null mice, where little 3-hydroxylation was found in type I collagen, 3-hydroxylation of type I collagen in affected horses is normal. The mutation disrupts the interaction of cyclophilin B with the P-domain of calreticulin, with lysyl hydroxylase 1, and probably other proteins, such as the formation of the P3H1·CypB·cartilage-associated protein complex, resulting in less effective catalysis of the rate-limiting step in collagen folding in the rough endoplasmic reticulum.
Selfishness and Malice in Distributed Systems

Large-scale distributed systems are increasingly prevalent. Two issues can impact the performance of such systems: selfishness and malice. Selfish players can reduce social welfare of games, and malicious nodes can disrupt networks. In this dissertation, we provide algorithms to address both of these issues. One approach to ameliorating selfishness in large networks is the idea of a mediator. A mediator implements a correlated equilibrium when it proposes a strategy to each player privately such that the mediator’s proposal is the best interest for every player to follow. In this dissertation, we present a mediator that implements the best correlated equilibrium for an extended El Farol game. The extended El Farol game we consider has both positive and negative network effects. We study the degree to which this type of mediator can decrease the social cost. In particular, we give an exact characterization of Mediation Value (MV ) and Enforcement Value (EV ) for this game. MV measures the efficiency of our mediator compared to the best Nash equilibrium, and EV measures the efficiency of our mediator
THE MIPSGAL VIEW OF SUPERNOVA REMNANTS IN THE GALACTIC PLANE

We report the detection of Galactic supernova remnants (SNRs) in the mid-infrared (at 24 and 70 μm), in the coordinate ranges 10° < l < 65° and 285° < l < 350°, |b| < 1°, using MIPS aboard the Spitzer Space Telescope. We search for infrared counterparts to SNRs in Green's catalog and identify 39 out of 121, i.e., a detection rate of about 32%. Such a relatively low detection fraction is mainly due to confusion with nearby foreground/background sources and diffuse emission. The SNRs in our sample show a linear trend in [F8/F24] versus [F70/F24]. We compare their infrared fluxes with their corresponding radio flux at 1.4 GHz and find that most remnants have a ratio of 70 μm to 1.4 GHz which is similar to those found in previous studies of SNRs (with the exception of a few that have ratios closer to those of H ii regions). Furthermore, we retrieve a slope close to unity when correlating infrared (24 and 70 μm) with 1.4 GHz emission. Our survey is more successful in detecting remnants with bright X-ray emission, which we find is well correlated with the 24 μm morphology. Moreover, by comparing the power emitted in the X-ray, infrared, and radio, we conclude that the energy released in the infrared is comparable to the cooling in the X-ray range.
Invisible Children : A Study Of Policy Exclusion

This research investigated a particular Government of India policy, known as the Integrated Child Development Scheme (or the ICDS). The ICDS operates amongst the poorer sections of the population in India, for pre-school children in the age range of 0-6 years. The IeDS policy, although it states that it is for 'all' children, does not in practice, address the question of disabled children. The research examined why and how such a major social policy in the country has omitted the disabled child from its agenda. It examined the socio-cultural attitudes towards disability in the Indian subcontinent and explored the wider historical, political and ideological framework in which Indian social policy for the disabled exists and within which the IeDS policy and practice may have become embedded. Data collection included exploratory field visits; focus group discussions; triangulations by follow-up interviews; semi-structured interviews; analysis of historical and current documents. The investigation concludes with the finding that various factors have led to disabled children being left out of the IeDS programmes. In the specific context of the IeDS, although it may have been the intention to include disabled children in the term 'all' children, there is a gap between policy stated and policy enacted, as the IeDS does not include them, in practice. The findings indicate that, due to ill-defined policy objectives during the policy formulation stage, policy remains silent on the issue, not clarifying that 'all' means disabled children as well. Implementation strategies for the inclusion of these children therefore are not worked out, which leads to the non-inclusion of disabled children from the programmes. In the wider context, the findings indicate that the national policy concerning disabled children lacks cohesion and does not give clear directives for the implementation of inclusion to take place. The Government's conceptualisation of disabled children is full of ambiguity and confusion: governmental reliance on voluntary organisations to deliver services ensures a micro-level coverage and indicates a lack of philosophical commitment to the integrated education of disabled children. Non-Government Organisations (NGOs) and their concentration on the delivery of services move the issue away from 2 a rights approach, leading to a disempowerment and depoliticisation of the disabled group. This takes the matter out of the public domain, making it a politically weak group and placing it within a charity framework. Negative attitudes, ignorance and a lack of awareness that prevails towards disability have also contributed to an overall ideological and cultural entrenchment in the subcontinent, contributing to marginalisation. The absence of a clear policy directive has left this segment of the population at a critical age out of the programmes of the ICDS.
The importance of the diurnal cycle of Aerosol Optical Depth in West Africa

High resolution atmospheric simulations with the AROME model coupled with a dust module over West Africa for the whole of June 2006 were used to calculate aerosol optical thickness (AOT). Simulations showed a significant diurnal cycle of 0.2 in the dust AOT that could not be inferred from the MODIS Deep Blue retrievals due to their timings. Dust sources are mainly driven by the breakdown of the early morning low‐level jet and by moist convection in the afternoon, leading to opposite diurnal cycles. Also, simulations show that cloud cover significantly prevents the observation of AOT. The under‐sampling of the diurnal cycle by satellites plus the impact of cloud masks on the space‐borne AOT retrievals induce an underestimation of 0.28 (~40%) over the convective regions and an overestimation of 0.1 (17%) over morning source areas like Bodélé. A combination of observations and high‐resolution models could constrain bias and give a more realistic AOT climatology.
The ergonomic design of workstations using virtual manufacturing and response surface methodology

The increasing use of computerized tools for virtual manufacturing in workstation design has two main advantages over traditional methods; first, it enables the designer to examine a large number of design solutions; and second, simulation of the work task may be performed in order to obtain the values of various performance measures. In this paper a new structural methodology for the workstation design is presented. Factorial experiments and the response surface methodology are integrated in order to reduce the number of examined design solutions and obtain an estimate for the best design configuration with respect to multi-objective requirements.
Imaging functional and structural networks in the human epileptic brain

Epileptic activity in the brain arises from dysfunctional neuronal networks involving cortical and subcortical grey matter as well as their connections via white matter fibres. Physiological brain networks can be affected by the structural abnormalities causing the epileptic activity, or by the epileptic activity itself. A better knowledge of physiological and pathological brain networks in patients with epilepsy is critical for a better understanding the patterns of seizure generation, propagation and termination as well as the alteration of physiological brain networks by a chronic neurological disorder. Moreover, the identification of pathological and physiological networks in an individual subject is critical for the planning of epilepsy surgery aiming at resection or at least interruption of the epileptic network while sparing physiological networks which have potentially been remodelled by the disease. This work describes the combination of neuroimaging methods to study the functional epileptic networks in the brain, structural connectivity changes of the motor networks in patients with localisation-related or generalised epilepsy and finally structural connectivity of the epileptic network. The combination between EEG source imaging and simultaneous EEG-fMRI recordings allowed to distinguish between regions of onset and propagation of interictal epileptic activity and to better map the epileptic network using the continuous activity of the epileptic source. These results are complemented by the first recordings of simultaneous intracranial EEG and fMRI in human. This whole-brain imaging technique revealed regional as well as distant haemodynamic changes related to very focal epileptic activity. The combination of fMRI and DTI tractography showed subtle changes in the structural connectivity of patients with Juvenile Myoclonic Epilepsy, a form of idiopathic generalised epilepsy. Finally, a combination of intracranial EEG and tractography was used to explore the structural connectivity of epileptic networks. Clinical relevance, methodological issues and future perspectives are discussed.
Cell type specific chromosome territory organization in the interphase nucleus of normal and cancer cells

Numerous studies indicate that the genome of higher eukaryotes is organized into distinct chromosome territories and that the 3‐D arrangement of these territories may be closely connected to genomic function and the global regulation of gene expression. Despite this progress, the degree of non‐random arrangement remains unclear and no overall model has been proposed for chromosome territory associations. To address this issue, a re‐FISH approach was combined with computational analysis to analysis the pair‐wise associations for six pairs of human chromosomes (chr #1, 4, 11, 12, 16, 18) in the G0 state of normal human WI38 lung fibroblast and MCF10A epithelial breast cells. Similar levels of associations were found in WI38 and MCF10A for several of the chromosomes whereas others showed striking differences. A novel computational geometric approach, the generalized median graph (GMG), revealed a preferred probabilistic arrangement distinct for each cell line. Statistical analysis demonstrated that ∼50% of the associations depicted in the GMG models are present in each individual nucleus. A nearly twofold increase of chromosome 4/16 associations in a malignant breast cancer cell line (MCFCA1a) compared to the related normal epithelial cell line (MCF10A) further demonstrates cancer related changes in chromosome arrangements. Our findings of highly preferred chromosome association profiles that are cell type specific and undergo alterations in cancer cells, lead us to propose a probabilistic chromosome code whereby the 3‐D association profile of chromosomes contributes to the functional landscape of the cell nucleus, the global regulation of gene expression and the epigenetic state of chromatin. J. Cell. Physiol. 221: 130–138, 2009. © 2009 Wiley‐Liss, Inc
The Relationship Between Physician Empathy and Disease Complications: An Empirical Study of Primary Care Physicians and Their Diabetic Patients in Parma, Italy

Purpose To test the hypothesis that scores of a validated measure of physician empathy are associated with clinical outcomes for patients with diabetes mellitus. Method This retrospective correlational study included 20,961 patients with type 1 or type 2 diabetes mellitus from a population of 284,298 adult patients in the Local Health Authority, Parma, Italy, enrolled with one of 242 primary care physicians for the entire year of 2009. Participating physicians’ Jefferson Scale of Empathy scores were compared with occurrence of acute metabolic complications (hyperosmolar state, diabetic ketoacidosis, coma) in diabetes patients hospitalized in 2009. Results Patients of physicians with high empathy scores, compared with patients of physicians with moderate and low empathy scores, had a significantly lower rate of acute metabolic complications (4.0, 7.1, and 6.5 per 1,000 patients, respectively, P < .05). Logistic regression analysis showed physicians’ empathy scores were associated with acute metabolic complications: odds ratio (OR) = 0.59 (95% confidence interval [CI], 0.37–0.95, contrasting physicians with high and low empathy scores). Patients’ age (≥69 years) also contributed to the prediction of acute metabolic complications: OR = 1.7 (95% CI, 1.2–1.4). Physicians’ gender and age, patients’ gender, type of practice (solo, association), geographical location of practice (mountain, hills, plain), and length of time the patient had been enrolled with the physician were not associated with acute metabolic complications. Conclusions These results suggest that physician empathy is significantly associated with clinical outcome for patients with diabetes mellitus and should be considered an important component of clinical competence.
Remembering Positive and Negative Life Events: Associations with Future Time Perspective and Functions of Autobiographical Memory

We examined distributions of remembered negative and positive life events across the lifespan in a sample of adults in middle and old age. Distributions of positive, but not negative, life events showed a significant reminiscence bump, replicating earlier findings. Gender differences occurred with respect to distribution of memories of positive life events of the first four decades of life. Furthermore, we found substantial associations of number and valence of remembered life events with future time perspective and functions of autobiographical memory to create meaning, which remained significant after controlling for age and health. The number and valence of negative and positive life events across the lifespan reflect, to a certain extent, the age and time perspective of the remembering individual.
Mott-Anderson Transition in Molecular Conductors: Influence of Randomness on Strongly Correlated Electrons in the κ-(BEDT-TTF)2X System

The Mott-Anderson transition has been known as a metal-insulator (MI) transition due to both strong electron-electron interaction and randomness of the electrons. For example, the MI transition in doped semiconductors and transition metal oxides has been investigated up to now as a typical example of the Mott-Anderson transition for changing electron correlations by carrier number control in concurrence with inevitable randomness. On the other hand, molecular conductors have been known as typical strongly correlated electron systems with bandwidth controlled Mott transition. In this paper, we demonstrate our recent studies on the randomness effect of the strongly correlated electrons of the BEDT-TTF molecule based organic conductors. X-ray irradiation on the crystals introduces molecular defects in the insulating anion layer, which cause random potential modulation of the correlated electrons in the conductive BEDT-TTF layer. In combination with hydrostatic pressure, we are able to control the parameters for randomness and correlations for electrons approaching the Mott-Anderson transition.
Do Teachers Read

ONE OF THE frequently stated goals of reading instruc ion is the development of a lifetime habit of reading? that is, the continuation of reading for the purposes of learning and recreation from childhood to adulthood. How this goal is achieved, however, is somewhat of a mystery. It seems safe to assume that, in part at least, a lifetime reading habit, or the desire to continue reading, is transmitted to children via modeling. That is, children tend to emulate and model the behavior of the important adults in their lives. Therefore, it would seem logical to assume further that the teacher who reads much would present a more positive and enthusiastic model than would the teacher who reads little. Furthermore, it is logical to assume that there is value in continued reading, both professional and nonprofessional. Long after the final degree has been earned, or the final course taken, reading remains one of the most important ways a teacher can continue to develop professionally and personally. Nevertheless, the reading habits of teachers is an area upon which few studies have focused. We therefore continue to make assumptions and draw conclusions without sufficient or appropriate data. If children use teachers as models, and this writer believes they do, then more interest in and concern over the reading habits of elementary and secondary school teachers ought to be expressed by researchers. There has always been concern over the reading habits of the adult popu lation in general (Sharon, 1973-74), and some researchers have been concerned with the reading habits of the "leaders" of our society (Weiss,
A Caprine Herpesvirus 1 Vaccine Adjuvanted with MF59™ Protects against Vaginal Infection and Interferes with the Establishment of Latency in Goats

The immunogenicity and the efficacy of a beta-propiolactone-inactivated caprine herpesvirus 1 (CpHV-1) vaccine adjuvanted with MF59™ were tested in goats. Following two subcutaneous immunizations, goats developed high titers of CpHV-1-specific serum and vaginal IgG and high serum virus neutralization (VN) titers. Peripheral blood mononuclear cells (PBMC) stimulated in vitro with inactivated CpHV-1 produced high levels of soluble IFN-gamma and exhibited high frequencies of IFN-gamma producing cells while soluble IL-4 was undetectable. On the other hand, control goats receiving the inactivated CpHV-1 vaccine without adjuvant produced only low serum antibody responses. A vaginal challenge with virulent CpHV-1 was performed in all vaccinated goats and in naïve goats to assess the efficacy of the two vaccines. Vaginal disease was not detected in goats vaccinated with inactivated CpHV-1 plus MF59™ and these animals had undetectable levels of infectious challenge virus in their vaginal washes. Goats vaccinated with inactivated CpHV-1 in the absence of adjuvant exhibited a less severe disease when compared to naïve goats but shed titers of challenge virus that were similar to those of naïve goats. Detection and quantitation of latent CpHV-1 DNA in sacral ganglia in challenged goats revealed that the inactivated CpHV-1 plus MF59™ vaccine was able to significantly reduce the latent viral load when compared either to the naïve goats or to the goats vaccinated with inactivated CpHV-1 in the absence of adjuvant. Thus, a vaccine composed of inactivated CpHV-1 plus MF59™ as adjuvant was strongly immunogenic and induced effective immunity against vaginal CpHV-1 infection in goats.