Miracle-dz/UniFAR-FTUs huggingface dataset:
Birth Weight and Lipids in a National Birth Cohort Study

Objective—To investigate the association between birth weight and lipid levels in a 53-year-old birth cohort from England, Scotland, and Wales. Methods and Results—Lipid levels were obtained from nonfasting blood samples, collected at the most recent follow-up of the MRC National Survey of Health and Development, for 2559 men and women. Regression models indicated that in men, a 1-kg increase in birth weight was associated with a 0.13-mmol/L decrease (95% CI: −0.23, −0.01) in total cholesterol at age 53 years (P =0.03), compared with a 0.02-mmol/L (95% CI: −0.11, 0.15) increase in women and a 0.06-mmol/L (95% CI: −0.15, 0.02) decrease in men and women combined. Adjustment for current height and body mass index (BMI) in men reduced the size of the relationship, with height being responsible for the reduction. Adult height and height at 2 and 4 years were significantly associated with total cholesterol in men and in men and women combined. The negative association between total cholesterol and birth weight was strongest among men with high BMI at age 53 years (P =0.03 for test for interaction between birth weight and BMI). There was no significant association between birth weight and LDL or HDL cholesterol in men or women before adjustment, but there was a positive association with HDL in women. When both sexes were analyzed together, an association was seen after adjustment for current body size. No confounding of these findings with social class was observed in this study. Conclusions—Our results suggest that the small effect of birth weight on lipid levels at age 53 years has a limited public health impact. The findings suggest that childhood height growth may be more important than prenatal growth.
Investigating the interchangeability and diagnostic utility of the PPVT-III and PPVT-IV for children with and without SLI

Abstract The receptive vocabulary performance of pre-school children with specific language impairment (SLI) and typically-developing (TD) controls was compared on the Peabody Picture Vocabulary Test third and fourth edition (PPVT-III and PPVT-IV) to determine consistency in performance and the effect of test revision on identification of impairment. Participants included 40 pre-school children with SLI and 40 controls. Tests were administered in counterbalanced order. Despite a strong relationship between performance on these two tests (p < 0.001), 35% of children performed differently between the two test versions. Children with SLI performed significantly worse than TD children on both tests (p < 0.001). Discriminate analyses identified an optimal standard score cut-off of 103 for both tests. Using this cut-off, sensitivity remained consistent at 80% (95% CI = 0.64–0.90), while specificity was 75% (95% CI = 0.59–0.87) on the PPVT-III and 70% (95% CI = 0.53–0.83) on the PPVT-IV. The results suggest that the two tests do not appear to be interchangeable for more than 1/3rd of children. The findings also highlight the misperception that newer test versions are superior to older in identifying presence or absence of language impairment. Children with SLI are unlikely to score low on these commonly used receptive vocabulary tests, despite known deficits of children with SLI in the area of vocabulary acquisition. Possible explanations for why children with SLI score well on these types of tests will be discussed.
Graph-based analysis of brain connectivity in schizophrenia

The present study evaluated brain connectivity using electroencephalography (EEG) data from 14 patients with schizophrenia and 14 healthy controls. Phase-Locking Value (PLV), Phase-Lag Index (PLI) and Directed Transfer Function (DTF) were calculated for the original EEG data and following current source density (CSD) transformation, re-referencing using the average reference electrode (AVERAGE) and reference electrode standardization techniques (REST). The statistical analysis of adjacency matrices was carried out using indices based on graph theory. Both CSD and REST reduced the influence of volume conducted currents. The largest group differences in connectivity were observed for the alpha band. Schizophrenic patients showed reduced connectivity strength, as well as a lower clustering coefficient and shorter characteristic path length for both measures of phase synchronization following CSD transformation or REST re-referencing. Reduced synchronization was accompanied by increased directional flow from the occipital region for the alpha band. Following the REST re-referencing, the sources of alpha activity were located at parietal rather than occipital derivations. The results of PLV and DTF demonstrated group differences in fronto-posterior asymmetry following CSD transformation, while for PLI the differences were significant only using REST. The only analysis that identified group differences in inter-hemispheric asymmetry was DTF calculated for REST. Our results suggest that a comparison of different connectivity measures using graph-based indices for each frequency band, separately, may be a useful tool in the study of disconnectivity disorders such as schizophrenia.
The presence of emphysema further impairs physiologic function in patients with idiopathic pulmonary fibrosis.

BACKGROUND Emphysema, especially in the upper lobes, is frequently observed in association with idiopathic pulmonary fibrosis (IPF). However, the combination of emphysema plus IPF has received little attention. OBJECTIVE To investigate the additional functional impairment from emphysema in IPF patients. METHODS Twenty-one patients (mean age 66 y, 20 men) (Group I) who had both IPF (mean 35% of total lung volume) and emphysema (mean 14% of total lung volume) were compared to a group of 21 subjects who had IPF but no emphysema (Group II). The groups were matched for (among other criteria) the total extent of disease. Pulmonary function tests, Medical Research Council dyspnea score, 6-min walk test, and radiographic extents of both IPF and emphysema were obtained for each patient. The Composite Physiologic Index was calculated. In the total population (n = 42), the independent contributions of IPF and emphysema to several physiologic variables were investigated by using stepwise multiple regression analysis. RESULTS Despite the limited extent of emphysema, Groups I and II had similar physiologic impairment. Only residual volume and total lung capacity were significantly higher in Group I. According to stepwise multiple regression analysis, the extent of IPF and either the presence or the extent of emphysema in the total population were independent and significant predictors of dyspnea score, 6-min walk test, P(aO2), forced expiratory volume in the first second (FEV(1)), forced vital capacity (FVC), FEV1/FVC, the diffusing capacity of the lung for carbon monoxide, carbon monoxide diffusing capacity adjusted for alveolar volume (gas-transfer coefficient), and residual volume. The Composite Physiologic Index was closely related to the extent of IPF (r = 0.65, p < 0.0001) and to the dyspnea score (rho = 0.59, p < 0.0001). CONCLUSIONS In former smokers with IPF, the presence and the extent of emphysema have a profound influence on physiologic function in terms of both further impairment and confounding effects.
Acceptable Outcome After Kidney Transplantation Using “Expanded Criteria Donor” Grafts

Introduction. With the worldwide shortage of donors, extra lengths are ongoing to enlarge the donor pool. One means has been a greater use of “expanded criteria donor” (ECD) grafts. A major concern regarding ECD kidneys is poor long-term graft survival. The aims of this study were to determine whether ECD grafts, as defined by the United Network for Organ Sharing, had a negative impact on graft survival and to identify the principle donor and recipient factors that influenced graft survival in our patient cohort. Methods. We analyzed all deceased donor renal transplants in our unit from January 1995 to October 2005, in total 1053 transplants. Results. ECD grafts (United Network for Organ Sharing criteria) demonstrated higher rates of delayed graft function and higher early mean creatinine levels. However, there was no significant difference in 5-year graft survival. Multivariate analysis of our patient group identified donor hypertension and ischemic heart disease (IHD) as independent predictors of poor graft survival. Recipient age was significant on univariate but not on multivariate analysis. However, although younger recipients maintained acceptable 5-year graft survival despite donor hypertension, IHD, or a combination of both, these factors significantly reduced graft survival in older recipients. Conclusion. Although ECD grafts had slightly worse function, 5-year survival was comparable with standard grafts in all recipients. Donor hypertension, IHD, or a combination of both significantly reduced graft survival in older recipients, not evident in younger patients. We discuss the possible factors for improved outcome with ECD grafts in our patients and the implications of our patient analysis.
Relativistic Jets from Collapsars

Using a collapsar progenitor model of MacFadyen & Woosley, we have simulated the propagation of an axisymmetric jet through a collapsing rotating massive star with the GENESIS multidimensional relativistic hydrodynamic code. The jet forms as a consequence of an assumed (constant or variable) energy deposition in the range of 1050-1051 ergs s-1 within a 30° cone around the rotation axis. The jet flow is strongly beamed (approximately less than a few degrees), spatially inhomogeneous, and time dependent. The jet reaches the surface of the stellar progenitor (R* = 2.98 × 1010 cm) intact. At breakout, the maximum Lorentz factor of the jet flow is 33. After breakout, the jet accelerates into the circumstellar medium, whose density is assumed to decrease exponentially and then become constant, ρext = 10-5 g cm-3. Outside the star, the flow begins to expand laterally also (v ~ c), but the beam remains very well collimated. At a distance of 2.54 R*, where the simulation ends, the Lorentz factor has increased to 44.
A Course on Effective Teacher-Child Interactions

Among 440 early childhood teachers, half were randomly assigned to take a 14-week course on effective teacher-child interactions. This course used the Classroom Assessment Scoring System (CLASS) as the basis to organize, describe, and demonstrate effective teacher-child interactions. Compared to teachers in a control condition, those exposed to the course reported more intentional teaching beliefs and demonstrated greater knowledge of and skills in detecting effective interactions. Furthermore, teachers who took the course were observed to demonstrate more effective emotional and instructional interactions. The course was equally effective across teachers with less than an associate’s degree as well as those with advanced degrees. Results have implications for efforts to improve the quality of early childhood programs through the higher education system.
Identification and Characterization of New Protein Chemoattractants in the Frog Skin Secretome*

The vomeronasal organ is a chemosensory organ present in most vertebrates and involved in chemical communication. In the last decade, the deciphering of the signal transduction process of this organ has progressed. However, less is known about the vomeronasal organ ligands and their structure-function relationships. Snakes possess a highly developed vomeronasal system that is used in various behaviors such as mating, predator detection, or prey selection, making this group a suitable model for study of the vomeronasal chemoreception. In this work, we used a proteomics approach to identify and characterize proteins from frog cutaneous mucus proteome involved in prey recognition by snakes of the genus Thamnophis. Herein we report the purification and characterization of two proteins isolated from the frog skin secretome that elicit the vomeronasal organ-mediated predatory behavior of Thamnophis marcianus. These proteins are members of the parvalbumin family, which are calcium-binding proteins generally associated to muscular and nervous tissues. This is the first report that demonstrates parvalbumins are not strictly restricted to intracellular compartments and can also be isolated from exocrine secretions. Purified parvalbumins from frog muscle and mucus revealed identical chemoattractive properties for T. marcianus. Snake bioassay revealed the Ca2+/Mg2+ dependence of the bioactivity of parvalbumins. So parvalbumins appear to be new candidate ligands of the vomeronasal organ.
Endemic Iron Deficiency Associated With Helicobacter pylori Infection Among School-Aged Children in Alaska

OBJECTIVES. Rural Alaska Natives have a high prevalence of iron deficiency and Helicobacter pylori infection. The objective of this study was to estimate the prevalence of iron deficiency, iron-deficiency anemia, and active H pylori infection among school-aged children in rural Alaska. METHODS. We enrolled 68% (688) of the 7- to 11-year-old children from 10 predominantly Alaska Native villages in southwestern Alaska. We collected venous blood samples to assess iron deficiency and anemia. Each child was tested for active H pylori infection by 13C-urea breath test (UBT). Evaluated risk factors included age, gender, village of residence, number of household members, number of household members who were younger than 5 years, recent antibiotic use, and household water source. RESULTS. Of 688 enrolled children, iron deficiency was present in 38%, iron-deficiency anemia was present in 7.8%, and H pylori infection by UBT was present in 86%. Iron deficiency was independently associated with living in a household with >6 people and village of residence. H pylori infection by UBT was independently associated with child's age ≥10 years and village of residence. Ninety-one percent of children with iron deficiency had H pylori infection by UBT, and children with active H pylori infection were more likely to be iron deficient than uninfected children. Children with H pylori infection by UBT were also more likely to have iron-deficiency anemia than uninfected children. CONCLUSIONS. In this study of nearly 700 children in 10 different villages in Alaska, we confirmed that the high prevalence of iron deficiency persists among school-aged children. We found that active H pylori infection was independently associated with iron deficiency and iron-deficiency anemia among children in this region. H pylori infection may account for a portion of the iron deficiency and iron-deficiency anemia in rural Alaska and other areas with high prevalences of both conditions. Innovative approaches are critically needed to address the iron deficiency in high prevalence areas such as rural Alaska and most of the developing world.
Interplanetary External Driven Quasidynamo as the Origin of Geomagnetic Jerks Correlated with Length of Day and Gravity Anomaly

Abstract We report phenomenological inevitable correlation between the Sun’s magnetic field oscillation through the Earth and the Jupiter, with sinusoidal geomagnetic jerks observed at the Earth, additionally aligned with the gravity and length of day sinusoidal variations and we observe too that the Sun and Jovian planets alignments with Jupiter are origin of the observable abrupt geomagnetic jerks whether historical or new, and experimental results demonstrate a possible explanation on the base of the planetary induced currents upon the metallic liquid cores of the planets upon the varying external magnetic fields as the source of heat flows continued by frictional turbulent and convectional fluid fluxes, amplified and expanding by the Earth magnetic field and observations are showing too that it should be an electric coupling effect between metallic cores of the planets, under the magnetic field oscillation so that Jupiter conductive metallic region interacts with Earth metallic core while the Sun’s magnetic field is oscillating through the Jupiter and we see a relation between secular variation of the Earth’s magnetic field and long term trend of 5.9-years signals as a new method to measure geomagnetic secular variation by LOD signals.
Many Parameter Sets in a Multicompartment Model Oscillator Are Robust to Temperature Perturbations

Neurons in cold-blooded animals remarkably maintain their function over a wide range of temperatures, even though the rates of many cellular processes increase twofold, threefold, or many-fold for each 10°C increase in temperature. Moreover, the kinetics of ion channels, maximal conductances, and Ca2+ buffering each have independent temperature sensitivities, suggesting that the balance of biological parameters can be disturbed by even modest temperature changes. In stomatogastric ganglia of the crab Cancer borealis, the duty cycle of the bursting pacemaker kernel is highly robust between 7 and 23°C (Rinberg et al., 2013). We examined how this might be achieved in a detailed conductance-based model in which exponential temperature sensitivities were given by Q10 parameters. We assessed the temperature robustness of this model across 125,000 random sets of Q10 parameters. To examine how robustness might be achieved across a variable population of animals, we repeated this analysis across six sets of maximal conductance parameters that produced similar activity at 11°C. Many permissible combinations of maximal conductance and Q10 parameters were found over broad regions of parameter space and relatively few correlations among Q10s were observed across successful parameter sets. A significant portion of Q10 sets worked for at least 3 of the 6 maximal conductance sets (∼11.1%). Nonetheless, no Q10 set produced robust function across all six maximal conductance sets, suggesting that maximal conductance parameters critically contribute to temperature robustness. Overall, these results provide insight into principles of temperature robustness in neuronal oscillators.
Testing monotone continuous distributions on high-dimensional real cubes

We study the task of testing properties of probability distributions. We consider a scenario in which we have access to independent samples of an unknown distribution D with infinite (perhaps even uncountable) support. Our goal is to test whether D has a given property or it is ε-far from it (in the statistical distance, with the L1-distance measure). It is not difficult to see that for many natural distributions on infinite or uncountable domains, no testing algorithm can exist and the central objective of our study is to understand if there are any nontrivial distributions that can be efficiently tested. For example, it is easy to see that there is no testing algorithm that tests if a given probability distribution on [0, 1] is uniform. We show however, that if some additional information about the input distribution is known, testing uniform distribution is possible. We extend the recent result about testing uniformity for monotone distributions on Boolean n-dimensional cubes by Rubinfeld and Servedio (STOC'2005) to the case of continuous [0, 1]n cubes. We show that if a distribution D on [0, 1]n is monotone, then one can test if D is uniform with the sample complexity O(n/ε2). This result is optimal up to a polylogarithmic factor.
Steady-state pharmacokinetics of rilpivirine under different meal conditions in HIV-1-infected Ugandan adults.

OBJECTIVES To investigate the effect of food on the steady-state pharmacokinetics of rilpivirine when administered as a fixed-dose combination tablet containing tenofovir disoproxil fumarate, emtricitabine plus rilpivirine (TDF/FTC/RPV) in HIV-1-infected Ugandan patients. METHODS This was an open-label, three-period, longitudinal pharmacokinetic study with patients serving as their own controls. Fifteen consenting and virologically suppressed HIV-1-infected adults were switched from an efavirenz-based regimen to TDF/FTC/RPV for 56 days. Enrolled patients underwent 24 h blood sampling with TDF/FTC/RPV dosing in the fasted state (day 42), with a low-fat meal (11 g of fat/353 kcal, day 49) and with a moderate-fat meal (19 g of fat/589 kcal, day 56; reference). A viral load assessment was performed on day 56. RESULTS Rilpivirine AUC0-24 was significantly decreased by 16% (geometric mean ratio, 90% CI: 0.84, 0.73-0.96) during administration in the fasted state when compared with AUC0-24 during administration with a moderate-fat meal. Similarly, rilpivirine C24 was significantly decreased by 21% (0.79, 0.65-0.97) in the fasted state compared with a moderate-fat meal. Pharmacokinetic parameters were unchanged during administration with a low-fat meal, except for C24, which was significantly increased by 15% (1.15, 1.01-1.31) when compared with the moderate-fat meal. Rilpivirine Cmax was similar under the three meal conditions. Virological suppression was unchanged at the end of the study. CONCLUSIONS A food effect was observed for steady-state pharmacokinetic parameters of rilpivirine (AUC0-24 and C24) when TDF/FTC/RPV was administered in the fasted state compared with the moderate-fat meal. The TDF/FTC/RPV formulation can be administered with either a low-fat or moderate-fat meal.
Impact of local information in growing networks

We present a new model of the evolutionary dynamics and the growth of on-line social networks. The model emulates people's strategies for acquiring information in social networks, emphasising the local subjective view of an individual and what kind of information the individual can acquire when arriving in a new social context. The model proceeds through two phases: (a) a discovery phase, in which the individual becomes aware of the surrounding world and (b) an elaboration phase, in which the individual elaborates locally the information trough a cognitive-inspired algorithm. Model generated networks reproduce main features of both theoretical and real-world networks, such as high clustering coefficient, low characteristic path length, strong division in communities, and variability of degree distributions.
Performance evaluation of IEEE 802.11p physical layer infrastructure-to-vehicle real-world measurements

We evaluate the physical layer of infrastructure-to-vehicle communications from real-world measurements. For the measurements, a prototypical implementation of IEEE 802.11p was deployed in two roadside units (RSUs) along a highway in Austria. The required signal-to-noise ratio (SNR) for achieving a frame-error-ratio (FER) less than 0.1 is estimated from measurements for various configurations of data rate, packet length, and vehicle speed. Evaluations show that for a RSU with an antenna mounted at a low height (1.8m) the required SNR depends on the packet length. This is not the case for a RSU, where the antenna is mounted higher (7.1 m). Further the averaged required SNR over all different parameter settings for the low RSU is 4.6 dB larger compared to the required SNR for the high RSU.
Detecting global bridges in networks

The identification of nodes occupying important positions in a network structure is crucial for the understanding of the associated real-world system. Usually, betweenness centrality is used to evaluate a node capacity to connect different graph regions. However, we argue here that this measure is not adapted for that task, as it gives equal weight to "local" centers (i.e. nodes of high degree central to a single region) and to "global" bridges, which connect different communities. This distinction is important as the roles of such nodes are different in terms of the local and global organisation of the network structure. In this paper we propose a decomposition of betweenness centrality into two terms, one highlighting the local contributions and the other the global ones. We call the latter bridgeness centrality and show that it is capable to specifically spot out global bridges. In addition, we introduce an effective algorithmic implementation of this measure and demonstrate its capability to identify global bridges in air transportation and scientific collaboration networks.