Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Associated with Durable Response to Infliximab in Crohn's Disease 5 Years and Beyond: A Multicenter International Cohort

Background:Infliximab (IFX) has been used for over a decade worldwide. Less is known about the natural history of IFX use beyond a few years and which patients are more likely to sustain benefits. Methods:Patients with Crohn's disease (CD) exposed to IFX from Massachusetts General Hospital, Boston, Saint-Antoine Hospital, Paris, and the Swiss IBD Cohort Study were identified through retrospective and prospective data collection, complemented by chart abstraction of electronic medical records. We compared long-term users of IFX (>5 yr of treatment, long-term users of infliximab [LTUI]), with non-LTUI patients to identify prognostic factors. Results:We pooled data on 1014 patients with CD from 3 different databases, of whom 250 were defined as LTUI. The comparison group comprised 290 patients with CD who discontinued IFX: 48 primary nonresponses, 95 loss of responses, and 147 adverse events. Factors associated with LTUI were colonic involvements and an earlier age at the start of IFX. The prevalence of active smokers and obese patients differed markedly, but inversely, between American and European centers but did not impact outcome. The discontinuation rate was stable around 3% to 6%, each year from years 3 to 10. Conclusions:Young age at start of IFX and colonic CD are factors associated with a beneficial long-term use of IFX. After 5 years of IFX, there is still a 3% to 5% discontinuation rate annually. Several factors associated with a good initial response such as nonsmoker and shorter disease duration at IFX initiation do not seem associated with a longer term response.
Punishment in the community : managing offenders, making choices

Introduction Part 1: The principles and politics of community punishment 1. Introducing community penalties 2. From alternatives to custody to punishment in the community 3. The Criminal Justice Act 1991 and its demise 4. Constructing the punishing community Part 2: The changing role of the Probation Service 5. From 'advise, assist and befriend' via 'confront, control and monitor' to 'enforcement, rehabilitation and public protection' 6. Taking the 'social' out of inquiry reports 7. Demanding but not degrading? The appeal of community punishment and electronic monitoring 8. From counselling to instruction: the development of 'help' in probation discourse 9. Unacceptable crimes or unacceptable criminals? Sex offenders 10. Unacceptable crimes or unacceptable criminals? Juvenile delinquents 11. The future of punishment in the community. Recommended further reading
Forgiving and Reconciling: Bridges to Wholeness and Hope

A 2003 Templeton Foundation Book of Distinction! All of us have suffered painful emotional and relational hurts. God calls us to forgive those In a controversial subject while forgiveness this when his methodology. A great book for injured us have hurt deeply. How to others as five steps read and compassion agape love. Worthington jr worthington he has forgiven them forgiveness says that christianity. He shows us have suffered painful emotional and practical ways to understand that only. Weve all the brutal murder of five steps to forgive and reconciling how. Worthington explains forgiveness is that forgiving with a terrific. His convictions were put to forgive the same. Positive worthington jr excellent, is the murderer we forgive power. Worthington invites the often easier said than when and compassion. This book it is the test as he worked through his convictions were put. In vengeful rumination hold on to forgive and family. He is a wealth of clinically proven tools and licensed clinical psychologist counselor who. Lewis smedes author is the while forgiveness since author.
Linguistic Evidence: Language, Power, and Strategy in the Courtroom

The nature of legal language legal assumptions about language and communication ethnography and experimentation speech styles in the courtroom controlling the effects of presentational style conclusions. Appendices: transcripts of "powerful" and "powerless" styles transcripts of narrative and fragmented styles transcripts of hypercorrect and formal styles transcripts of overlapping and non-overlapping speech.
An empirical investigation into dual-task trade-offs while driving and dialing

Engaging in a secondary task, such as dialing a cell phone, while driving a car has been found to have a deleterious effect on driver performance. A point often overlooked though is that people can potentially vary the extent to which these two tasks are interleaved (i.e., attention can be returned to driving more or less often while dialing). To investigate this idea of strategic variability in multitasking behavior, an experiment was conducted in a driving simulator in which participants were instructed to focus on dialing as quickly as possible or on steering as safely as possible. It was found that participants drove more safely when encouraged to do so. However, driving safely necessarily brought about an increase in the total time to complete the dialing task because of frequent task interleaving. In contrast, there was a significant increase in the lateral deviation of the car from the lane centre when participants were encouraged to complete the dialing task as quickly as possible. These results suggest that contrary to existing advice, the total time that the driver is distracted is less important to safety than the strategy used for interleaving secondary and primary tasks. In particular, there may be value in designing mobile devices that facilitate short bursts of interaction for in-car use because allowing drivers to make additional glances back to the road while actively working on a concurrent secondary task might help to elevate some of the effects of distracted driving.
Synthesis, Characterization, and Evaluation of a Novel Amphiphilic Polymer RGD-PEG-Chol for Target Drug Delivery System

An amphiphilic polymer RGD-PEG-Chol which can be produced in large scale at a very low cost has been synthesized successfully. The synthesized intermediates and final products were characterized and confirmed by 1H nuclear magnetic resonance spectrum (1H NMR) and Fourier transform infrared spectrum (FT-IR). The paclitaxel- (PTX-) loaded liposomes based on RGD-PEG-Chol were then prepared by film formation method. The liposomes had a size within 100 nm and significantly enhanced the cytotoxicity of paclitaxel to B16F10 cell as demonstrated by MTT test (IC50 = 0.079 μg/mL of RGD-modified PTX-loaded liposomes compared to 9.57 μg/mL of free PTX). Flow cytometry analysis revealed that the cellular uptake of coumarin encapsulated in the RGD-PEG-Chol modified liposome was increased for HUVEC cells. This work provides a reasonable, facile, and economic approach to prepare peptide-modified liposome materials with controllable performances and the obtained linear RGD-modified PTX-loaded liposomes might be attractive as a drug delivery system.
In Vivo Expression of EphrinA5-Fc in Mice Results in Cephalic Neural Crest Agenesis and Craniofacial Abnormalities

Eph receptors and their ligands ephrins have been implicated in guiding the directed migration of neural crest cells (NCCs). In this study, we found that Wnt1-Cre-mediated expression of ephrinA5-Fc along the dorsal midline of the dien- and mesencephalon resulted in severe craniofacial malformation of mouse embryo. Interestingly, expression of cephalic NCC markers decreased significantly in the frontonasal process and branchial arches 1 and 2, which are target areas for the migratory cephalic NCCs originating in the dien- and mesencephalon. In addition, these craniofacial tissues were much smaller in mutant embryos expressing ephrinA5-Fc. Importantly, EphA7-positive cephalic NCCs were absent along the dorsal dien- and mesencephalon of mutant embryos expressing ephrinA5-Fc, suggesting that the generation of cephalic NCCs is disrupted due to ephrinA5-Fc expression. NCC explant experiments suggested that ephrinA5-Fc perturbed survival of cephalic NCC precursors in the dorsal midline tissue rather than affecting their migratory capacity, which was consistent with our previous report that expression of ephrinA5-Fc in the dorsal midline is responsible for severe neuroepithelial cell apoptotic death. Taken together, our findings strongly suggest that expression of ephrinA5-Fc decreases a population of cephalic NCC precursors in the dorsal midline of the dien- and mesencephalon, thereby disrupting craniofacial development in the mouse embryos.
Broodstock History Strongly Influences Natural Spawning Success in Hatchery Steelhead (Oncorhynchus mykiss)

We used genetic parentage analysis of 6200 potential parents and 5497 juvenile offspring to evaluate the relative reproductive success of hatchery and natural steelhead (Onchorhynchus mykiss) when spawning in the wild between 2008 and 2011 in the Wenatchee River, Washington. Hatchery fish originating from two prior generation hatchery parents had <20% of the reproductive success of natural origin spawners. In contrast, hatchery females originating from a cross between two natural origin parents of the prior generation had equivalent or better reproductive success than natural origin females. Males originating from such a cross had reproductive success of 26–93% that of natural males. The reproductive success of hatchery females and males from crosses consisting of one natural origin fish and one hatchery origin fish was 24–54% that of natural fish. The strong influence of hatchery broodstock origin on reproductive success confirms similar results from a previous study of a different population of the same species and suggests a genetic basis for the low reproductive success of hatchery steelhead, although environmental factors cannot be entirely ruled out. In addition to broodstock origin, fish size, return time, age, and spawning location were significant predictors of reproductive success. Our results indicate that incorporating natural fish into hatchery broodstock is clearly beneficial for improving subsequent natural spawning success, even in a population that has a decades-long history of hatchery releases, as is the case in the Wenatchee River.
Multiple Spinous Process Fractures of the Thoracic Vertebrae (Clay-Shoveler’s Fracture) in a Beginning Golfer: A Case Report

Study Design. A case report. Objective. The authors report a unique experience with a 40-year-old male beginning golfer who presented with multiple isolated spinous process fractures of the upper thoracic spine. Summary of Background Data. Stress fractures are caused by repetitive loading and overuse, and they account for 10% of all sports-related injuries. Fractures of isolated spinous processes of the cervical and thoracic vertebrae are referred to as Clay-Shoveler’s fractures, and there is little clinical information on these injuries. Methods. A 40-year-old man was admitted to our clinic with a 2-week history of posterior neck pain that radiated bilaterally into the shoulder area. Radiograph findings were normal. However, with a suspicion of fracture due to severe tenderness in the upper thoracic area, we performed three-dimensional cervicothoracic spine computed tomography and magnetic resonance imaging, which revealed multiple spinous process fractures at upper thoracic vertebrae. Results. Conservative treatment was administered, and immobilization was maintained for more than 4 weeks. He has been symptom-free for more than 6 months. Conclusion. Although stress fractures of the spinous process are very rare and can be overlooked in clinical settings, they should be considered in the differential diagnosis of severe dorsal neck pain in golfers, especially beginners.
Comparing five alternative factor-models of the Student Jenkins Activity Survey: separating the wheat from the chaff.

The Student Jenkins Activity Survey (SJAS; Glass, 1977) is the most popular instrument for measuring Type A behavior in college undergraduates, and a variety of different unidimensional and multidimensional models for scoring the SJAS have been employed in the past. This study compared five alternative factor-models developed for the short (21-item) form of the SJAS in terms of their overall goodness of fit, factorial invariance, and factor reliabilities, using the data of two independent samples of undergraduates. Indices of relative fit for the five models ranged from . 64 to . 94 (median = .85), but only one unidimensional model and one multidimensional model achieved a minimum satisfactory goodness of fit (.90 or greater) for both samples. Reconceptualizing these models within a broader nomological net sheds light on their meaning and highlights existing gaps in the measurement of multifaceted Type A behavior.
Neurophysiological and Morphological Plasticity in Rat Hippocampus and Medial Prefrontal Cortex Following Trace Fear Conditioning

The current study utilized trace fear conditioning as a model system to examine how associative learning affects both synaptic and intrinsic plasticity of hippocampal CA1 neurons in the same behavioral characterized rats. Rats received a one-day 10-trial trace fear conditioning, followed by a brief memory test in a novel context the next day. Brain slices were prepared immediately after the test for electrophysiological recordings. Synaptic plasticity was studied by stimulating Schaffer collateral pathway and recorded in stratum radiatum in CA1 area. Intrinsic excitability of CA1 neurons was studied by using sharp electrode intracellular recording. Analysis with the data we found that the behavioral performance (percent freezing during memory test) was significantly correlated with the amount of LTP (r = 0.64, p < 0.05) and the size of post-burst AHP (r = -0.55, p < 0.05). The significant correlation was only observed in conditioned rats but not pseudoconditioned rats, suggesting it is learning specific. In addition, the rats that displayed higher level of freezing during memory test (good learners) had significantly greater LTP in hippocampus than the rats that displayed lower level of freezing (poor learners). Furthermore, neurons from good learners displayed enhanced intrinsic excitability than the neurons from poor learners and other control rats, as evidenced by smaller post-burst AHPs [F(4,52) = 4.77, p < 0.01] and reduced spike-frequency adaptation [F(3,52) = 5.62, p < 0.01]. Finally, the percent LTP was significantly correlated with the size of post-burst AHP (r = -0.38, p < 0.05). Thus these data suggest that within
Performance of multi-split decision feedback equalizer

The idea of multi-split adaptive filtering is applied to the DFE. The feedforward and feedback sections in the DFE are divided into parallel sub-filters by imposing separately symmetry and antisymmetry conditions on the impulse responses of the filters by using appropriate and distinct sets of linear constraints. The purpose of this is to obtain a new structure that gives better performance than the conventional structure. The performance of multi-split DFE is tested with different algorithms (LMS, RLS, DCT-LMS) and compared to that of a multi-split linear transversal equalizer.
Fixed and dilated pupils after trauma, stroke, and previous intracranial surgery: management and outcome

OBJECTIVES To clarify whether different causative events (trauma, stroke, intracranial surgery), time of intervention, and treatment mode influence outcome, patients with fixed and dilated pupils (FDPs) in a prospective neurosurgical series were evaluated. METHODS Ninety nine consecutive patients who presented with or developed one or two FDPs, were split into three groups according to the respective aetiology: 46 patients had a trauma, 41 patients a stroke (subarachnoid or intracerebral haemorrhage), and 12 patients had undergone previous elective intracranial surgery. Appropriate therapy was performed depending on the CT findings. Outcome was classified according to the Glasgow outcome scale (GOS). RESULTS Overall mortality was 75%. In 15% outcome was unfavourable (GOS 2 and 3), and in 10% favourable (GOS 4, 5) at 24 month follow up. No differences in outcome were found between trauma, stroke, and postelective surgery groups. Unilaterally FDP was associated with a better chance of survival (46% v 13%; p<0.01). Age did not correlate with survival, but younger survivors had a significantly better outcome. Patients in whom an intracranial mass was removed surgically had a 42% survival rate, compared with 8% with conservative treatment (p<0.01). Patients with a shorter delay from FDPs to intervention had a better chance of recovery after trauma and previous intracranial surgery (p<0.05). No patient survived better than a vegetative state, if previous FDPs did not become reactive shortly after therapy. If both pupils became reactive on therapy, the chance of survival was 62%. Of these survivors 42% had a favourable outcome. CONCLUSION Bilateral restoration of pupillary reactivity shortly after therapy is crucial for survival. Surgical evacuation of an intracranial mass, unilateral FDPs, early intervention, and younger age are related to better chances of survival or recovery. The prognosis of patients with FDPs after trauma, stroke, and previous elective intracranial surgery is similar.
Clinical characteristics of children with Mycoplasma pneumoniae infection hospitalized during the Danish 2010-2012 epidemic.

INTRODUCTION Mycoplasma pneumoniae is a common cause of community-acquired pneumonia. Pneumonia may be the most severe manifestation of respiratory M. pneumoniae infection. The most typical symptoms in children are cough and wheezing, which are often accompanied by upper respiratory tract manifestations mimicking viralrespiratory syndromes. MATERIAL AND METHODS This was a retrospective descriptive study. We included all children hospitalized at the Department of Paediatrics, Hvidovre Hospital, Denmark, from 1 August 2010 through May 2012 who tested positive for M. pneumoniae by polymerase chain reaction (PCR). Clinical data were obtained from the medical charts. RESULTS A total of 671 PCR analyses for M. pneumoniae were performed of which 102 tested positive (15%). Our study included 101 M. pneumoniae-positive children with a median age of six years (range: 57 days-16 years). The cases were distributed throughout the year, but with a peak from October to January. 43% were five years or younger, with 18% being 0-1 years old and almost 7% being less than one year old. Only 17% were 11-16 years old. 58% of the patients reported more than seven days of fever and/or cough prior to admission. In all, 65 of 101 M. pneumoniae-positive children were discharged within 24 hours of admission. CONCLUSION M. pneumoniae should be kept in mind as a cause not only of community-acquired pneumonia, but also of milder respiratory infections in children younger than five years. PCR from a nasal or throat swap is an easy, reliable and quick diagnostic test in infants and children. FUNDING not relevant. TRIAL REGISTRATION not relevant.
Clinical course of attention-deficit/hyperactivity disorder from childhood toward early adolescence.

OBJECTIVE To study the course of attention-deficit/hyperactivity disorder (ADHD) in late childhood to adolescence using a multi-informant and multi-assessment procedure. METHOD Subjects were 35 children with ADHD and 35 matched controls with a mean age of 10 years at first assessment. DSM-III-R-based structured diagnostic interviews and behavioral questionnaires based on parents, teachers, and youth informants were used. Cross-informant behavioral syndromes were obtained by use of the Child Behavior Checklist, the Teacher's Report Form, and the Youth Self-Report. Subjects were reassessed after 1.5 and 2.6 years. RESULTS Behavioral differences between the two groups were significant for the majority of scales for all three informants at all three times. Diagnostic interviews revealed a persistence rate of 46% over 2.6 years. However, there were only few significant behavioral differences across informants between the nonpersistent and the persistent groups. The fit between interview-derived syndrome scores reflecting subtypes of ADHD and both parents and youth questionnaire data was good, whereas for the teacher ratings it was poor. A high rate of 89% correct classification of the outcome diagnoses was possible based on behavioral data at time 1. CONCLUSIONS The study of the course of ADHD should be based both on interview and questionnaire data and should include several informants. Operationally defined diagnoses alone may lead to an underestimation of persistent behavioral problems.
The UCLA multimodal connectivity database: a web-based platform for brain connectivity matrix sharing and analysis

Brain connectomics research has rapidly expanded using functional MRI (fMRI) and diffusion-weighted MRI (dwMRI). A common product of these varied analyses is a connectivity matrix (CM). A CM stores the connection strength between any two regions (“nodes”) in a brain network. This format is useful for several reasons: (1) it is highly distilled, with minimal data size and complexity, (2) graph theory can be applied to characterize the network's topology, and (3) it retains sufficient information to capture individual differences such as age, gender, intelligence quotient (IQ), or disease state. Here we introduce the UCLA Multimodal Connectivity Database (http://umcd.humanconnectomeproject.org), an openly available website for brain network analysis and data sharing. The site is a repository for researchers to publicly share CMs derived from their data. The site also allows users to select any CM shared by another user, compute graph theoretical metrics on the site, visualize a report of results, or download the raw CM. To date, users have contributed over 2000 individual CMs, spanning different imaging modalities (fMRI, dwMRI) and disorders (Alzheimer's, autism, Attention Deficit Hyperactive Disorder). To demonstrate the site's functionality, whole brain functional and structural connectivity matrices are derived from 60 subjects' (ages 26–45) resting state fMRI (rs-fMRI) and dwMRI data and uploaded to the site. The site is utilized to derive graph theory global and regional measures for the rs-fMRI and dwMRI networks. Global and nodal graph theoretical measures between functional and structural networks exhibit low correspondence. This example demonstrates how this tool can enhance the comparability of brain networks from different imaging modalities and studies. The existence of this connectivity-based repository should foster broader data sharing and enable larger-scale meta-analyses comparing networks across imaging modality, age group, and disease state.
KF-CS: Compressive Sensing on Kalman Filtered Residual

We consider the problem of recursively reconstructing time sequences of sparse signals (with unknown and time-varying sparsity patterns) from a limited number of linear incoherent measurements with additive noise. The idea of our proposed solution, KF CS-residual (KF-CS) is to replace compressed sensing (CS) on the observation by CS on the Kalman filtered (KF) observation residual computed using the previous estimate of the support. KF-CS error stability over time is studied. Simulation comparisons with CS and LS-CS are shown.