Miracle-dz/UniFAR-FTUs huggingface dataset:
Compressive Behaviour of Long-Fibre Unidirectional Composites

OMPOSITE MATERIALS ARE beginning to be used in an increasing number of C applications. To improve the mechanical properties of composites, higher performance fibres along with tougher matrices are being developed. With these developments it is essential that the failure mechanisms within composite materials are fully understood so that full utilisation of their properties is attained. As yet, no completely satisfactory understanding of the compressive behaviour of long-fibre composites is available, although many models of failure have been proposed. One reason for the variety of models is that compressive failure of long-fibre composites is not unique. Several failure modes are possible, depending on fibre volume fraction and the mechanical properties of both fibre and matrix. Also, the difficulty in obtaining compressive data for both fibre and matrix, along with data for unidirectional laminates has complicated verification of proposed theories. Notwithstanding these difliculties, a theoretical model to describe compressive behaviour is developed where it is postulated that there are four compressive failure modes (gross Euler buckling is not considered). Tensile failure mode occurs if the matrix is ductile and fibre tensile failure strain is greater than matrix and interface failure strain. Fibres bend out of phase, until transverse tensile stresses cause longitudinal splits in either the matrix or interface. Shear failure mode occurs if the matrix is ductile and fibre shear failure strain is greater than matrix and interface failure strain. Fibres bend in phase, until shear stresses cause failure in either the matrix or interface. Fibre failure mode occurs when fibre shear failure strain is lower than matrix and interface failure strain. Fibres bend in phase until shear stresses cause fibre
Large retinal ganglion cells that form independent, regular mosaics in the ranid frogs Rana esculenta and Rana pipiens

Abstract Population-based studies of ganglion cells in retinal flatmounts have helped to reveal some of their natural types in mammals, teleost fish and, recently, the aquatic mesobatrachian frog Xenopus laevis. Here, ganglion cells of the semiterrestrial neobatrachian frogs Rana esculenta and Rana pipiens have been studied similarly. Ganglion cells with large somata and thick dendrites could again be divided into three mosaic-forming types with distinctive stratification patterns. Cell dimensions correlated inversely with density, being smallest in the visual streak. Cells of the αa mosaic (<0.2% of all ganglion cells) had the largest somata at each location (often displaced) and their trees were confined to one shallow plane within sublamina a of the inner plexiform layer. In regions of high regularity, many trees were symmetric. Elsewhere, asymmetric, irregular trees predominated and their dendrites, although sparsely branched, achieved consistent coverage by intersecting in complex ways. Cells of the αab mosaic were more numerous (≈0.7%) and had large somata, smaller (but still large) trees, and dendrites that branched extensively in two separate shallow planes in sublaminae a and b. The subtrees did not always match in symmetry, and each subtree tessellated independently with its neighbors. Cells of the αc mosaic (≈0.1%) had large, orthotopic somata and large, sparse trees (often asymmetric and irregular) close to the ganglion cell layer. Nearest-neighbor analyses and spatial correlograms confirmed that each mosaic was regular and independent. Densities, proportions, sizes, and mosaic statistics are tabulated for all three types, which are compared with types defined by size and symmetry in R. pipiens, by discriminant analysis in R. temporaria, by physiological response in both, and by mosaic analysis in Xenopus and several teleosts. The variable stratification of these otherwise similar types across species is consistent with other evidence that stratification may be determined, in part, by functional interactions.
Impaired response to exercise intervention in the vasculature in metabolic syndrome

Physical activity decreases risk for diabetes and cardiovascular disease morbidity and mortality; however, the specific impact of exercise on the diabetic vasculature is unexamined. We hypothesized that an acute, moderate exercise intervention in diabetic and hypertensive rats would induce mitochondrial biogenesis and mitochondrial antioxidant defence to improve vascular resilience. SHHF/Mcc-facp lean (hypertensive) and obese (hypertensive, insulin resistant), as well as Sprague Dawley (SD) control rats were run on a treadmill for 8 days. In aortic lysates from SD rats, we observed a significant increase in subunit proteins from oxidative phosphorylation (OxPhos) complexes I–III, with no changes in the lean or obese SHHF rats. Exercise also increased the expression of mitochondrial antioxidant defence uncoupling protein 3 (UCP3) (p < 0.05) in SHHF lean rats, whereas no changes were observed in the SD or SHHF obese rats with exercise. We evaluated upstream signalling pathways for mitochondrial biogenesis, and only peroxisome proliferators–activated receptor gamma coactivator 1α (PGC-1α) significantly decreased in SHHF lean rats (p < 0.05) with exercise. In these experiments, we demonstrate absent mitochondrial induction with exercise exposure in models of chronic vascular disease. These findings suggest that chronic vascular stress results in decreased sensitivity of vasculature to the adaptive mitochondrial responses normally induced by exercise.
Depression and the Risk of Myocardial Infarction and Coronary Death

AbstractFindings regarding the association between depression and risk of coronary heart disease are inconsistent. We aimed to assess the association between depression and risk of myocardial infarction (MI) and coronary death through a meta-analysis.We performed an electronic literature search of MEDLINE, EMBASE, PsycINFO, ISI Web of Science, and Scopus databases through August 1, 2015, and manual search of the references of the eligible papers and related review articles. Two investigators independently conducted study selection and data abstraction. Disagreement was resolved by consensus. Confounder-adjusted hazard ratios (HRs) were pooled using a random-effects model. Heterogeneity was evaluated using the Cochran Q statistic and Higgins index. Publication bias was assessed by funnel plot and Egger test. Study quality was appraised with the Newcastle-Ottawa Scale.Among 19 eligible cohort studies including 323,709 participants, 8447 cases of MI and coronary death were reported during follow-up ranging from 4 to 37 years. The pooled adjusted HRs for patients with depression (vs those without) were 1.22 (95% CI, 1.13–1.32) for combined MI and coronary death, 1.31 (95% CI, 1.09–1.57) for MI alone (9 studies), and 1.36 (95% CI, 1.14–1.63) for coronary death alone (8 studies). The increased risk of MI and coronary death associated with depression was consistent using modified inclusion criteria, across most subgroups, and after adjusting for possible publication bias.Depression is associated with a significantly increased risk of MI and coronary death. Effective prevention and treatment of depression may decrease such risk.
The extended serial subculture of human diploid fibroblasts on microcarriers using a new medium supplement formulation

Human diploid fibroblasts serially passaged on microcarriers exhibit a decrease in their proliferative capacity with each transfer from microcarrier‐to‐microcarrier. This phenomenon, which does not occur in the same time scale with cells cultured in T‐flasks, has been a serious barrier to the systematic utilization of microcarriers in the scale‐up of anchorage‐dependent human diploid cell cultures. This decreases in cell growth with each passage is shown to be related to the serum content of the medium, with high serum concentrations resulting in a more rapid decrease in cell growth with each serial transfer. As a result, methods for reducing the serum requirement of the cells were investigated. A new medium supplement mixture, PPRF92, has been developed, which allows the serial passaging of MRC5 cells on Cytodex 1 microcarriers through as many as 13 microcarrier‐to‐microcarrier tranfers, and at a serum levels as low as 1%, with no decrease in the proliferative capacity of the cells until they approach their reported population doubling limit. This new supplement mixture is a significant improvement to microcarrier technology in that it enables the use of microcarriers in the early stages of inocculum build‐up for the production purposes. © 1992 John Wiley & Sons, Inc.
Screening and Brief Interventions for Hazardous and Harmful Alcohol Use among University Students in South Africa: Results from a Randomized Controlled Trial

The aim of this study was to assess the effectiveness of Screening and Brief Intervention (SBI) for alcohol problems among university students in South Africa. The study design for this efficacy study is a randomized controlled trial with 6- and 12-month follow-ups to examine the effects of a brief alcohol intervention to reduce alcohol use by hazardous and harmful drinkers in a university setting. The unit of randomization is the individual university student identified as a hazardous or harmful drinker attending public recruitment venues in a university campus. University students were screened for alcohol problems, and those identified as hazardous or harmful drinkers were randomized into an experimental or control group. The experimental group received one brief counseling session on alcohol risk reduction, while the control group received a health education leaflet. Results indicate that of the 722 screened for alcohol and who agreed to participate in the trial 152 (21.1%) tested positive for the Alcohol Use Disorder Identification Test (AUDIT) (score 8 or more). Among the 147 (96.7%) university students who also attended the 12-month follow-up session, the intervention effect on the AUDIT score was −1.5, which was statistically significant (P = 0.009). Further, the depression scores marginally significantly decreased over time across treatment groups, while other substance use (tobacco and cannabis use), self-rated health status and Posttraumatic Stress Disorder (PTSD) scores did not change over time across treatment groups. The study provides evidence of effective brief intervention by assistant nurses with hazardous and harmful drinkers in a university setting in South Africa. The short duration of the brief intervention makes it a realistic candidate for use in a university setting.
Neurobehavioral Performance of Residents After Heavy Night Call Versus After Alcohol Ingestion

CONTEXT The Institute of Medicine has called for increased rigor of education research and funding to support educational innovation. However, funding for medical education research is scarce. The costs of conducting studies in medical education and how such research is currently funded have not been systematically evaluated. OBJECTIVES To determine how medical education research studies that were recently published were funded and to approximate the costs of conducting these studies. DESIGN, SETTING, AND PARTICIPANTS We conducted a cross-sectional survey of first authors of medical education studies published from September 1, 2002, to December 31, 2003. Original medical education research studies conducted at US institutions and published in 13 prominent peer-reviewed journals were included. MAIN OUTCOME MEASURES For each study we measured duration, percentage of the authors' total work commitment ("percentage effort") devoted to the study, resources used and their costs, attainment of funding, and the first author's estimated cost of conducting the study. The cost of each study was calculated by multiplying the percentage effort of each author for the duration of the study by the national median salary for each author, according to specialty and academic rank, and then adding the costs of resources used. RESULTS Responses were received from authors of 243 (84%) of 290 identified medical education studies. The median calculated cost of conducting the 243 studies was 24,471 dollars (interquartile range [IQR], 11,531 dollars-63 808 dollars). The median authors' estimate of study cost was 10,000 dollars (IQR, 4000 dollars-25 000 dollars). Some funding was obtained for 72 (29.6%) of the studies. Of studies that were funded, the median amount of funding was 15,000 dollars (IQR, 5000 dollars-66,500 dollars). The median calculated cost of funded studies was 37,315 dollars (IQR, 18,731 dollars-82,393 dollars). Private foundation grants were the most common funding source (n = 30 [41.7%]). Factors independently associated with attaining funding were training in grant writing (odds ratio, 2.05; 95% confidence interval, 1.11-3.79) and number of medical education studies published by the first author (odds ratio, 2.4; 95% confidence interval, 1.24-4.63). CONCLUSIONS The majority of published medical education research is not formally funded, and the studies that do receive support are substantially underfunded. To realize the Institute of Medicine's directive and to improve the quality of medical research, policy reform that increases funding for medical education scholarship will likely be required.
Compiler optimization-space exploration

To meet the demands of modern architectures, optimizing compilers must incorporate an ever larger number of increasingly complex transformation algorithms. Since code transformations may often degrade performance or interfere with subsequent transformations, compilers employ predictive heuristics to guide optimizations by predicting their effects a priori. Unfortunately, the unpredictability of optimization interaction and the irregularity of today's wide-issue machines severely limit the accuracy of these heuristics. As a result, compiler writers may temper high variance optimizations with overly conservative heuristics or may exclude these optimizations entirely. While this process results in a compiler capable of generating good average code quality across the target benchmark set, it is at the cost of missed optimization opportunities in individual code segments. To replace predictive heuristics, researchers have proposed compilers which explore many optimization options, selecting the best one a posteriori. Unfortunately, these existing iterative compilation techniques are not practical for reasons of compile time and applicability. We present the Optimization-Space Exploration (OSE) compiler organization, the first practical iterative compilation strategy applicable to optimizations in general-purpose compilers. Instead of replacing predictive heuristics, OSE uses the compiler writer's knowledge encoded in the heuristics to select a small number of promising optimization alternatives for a given code segment. Compile time is limited by evaluating only these alternatives for hot code segments using a general compile-time performance estimator An OSE-enhanced version of Intel's highly-tuned, aggressively optimizing production compiler for IA-64 yields a significant performance improvement, more than 20% in some cases, on Itanium for SPEC codes.
CHARACTERIZING QUALITY AND COMPOSITION OF BEEF DERIVED FROM CATTLE FED STEAM-FLAKED CORN DIETS WITH COMBINATIONS OF DRY-ROLLED CORN AND DRIED DISTILLER'S GRAINS WITH SOLUBLES

A trial was conducted replacing portions of steam-flaked corn with either dry-rolled corn or dried distiller’s grains with solubles to evaluate effects on performance, carcass characteristics, carcass composition, meat color stability, and meat sensory attributes. Seven hundred crossbred yearling heifers (302 ± 65 kg initial BW) were used in a randomized complete block experiment with a 2 × 2 factorial arrangement of treatments. All diets contained steamflaked corn (SFC), and factors consisted of the levels of dry-rolled corn (DRC; 0 or 25%) and dried corn distiller’s grains with solubles (DDGS; 0 or 25%). Results revealed no interactions between DRC and DDGS in terms of effects on feedlot performance, and only minor interactive effects were observed for carcass characteristics and meat quality attributes. Feedlot performance and carcass characteristics were not affected by the addition of DRC or DDGS (P > 0.05). Carcass composition and meat quality attributes were measured to determine if fat content of carcasses was altered by feeding DDGS. Diet had no significant effects, as carcasses from the four treatments contained similar amounts of separable portions of muscle, adipose, and bone; and similar percentages of protein, moisture, and ether extract. Compositions of both adipose and muscle tissue were evaluated to assess differences in fatty acid profile. Minimal effects were noted on the fatty acid profiles of the muscle and adipose tissue from cattle fed DDGS or DRC. Feeding cattle DDGS decreased alpha tocopherol (vitamin E) content of meat (P < 0.05). Meat quality attributes were largely unaffected by addition of DRC or DDGS to the diet, as retail color display life, lipid oxidation, sensory attributes, and heterocyclic amine concentrations were not different among treatments. Overall, DRC or DDGS can replace portions of SFC without negatively altering feedlot performance, carcass characteristics, meat composition, or meat quality attributes.
A study on the growth characteristics of green algae blooms in the Yellow Sea using categorical analysis

Green algae (Enteromorpha prolifera) bloom, also known as the green tide, is becoming a new type of marine ecological disaster. More and more studies have been conducted to investigate the cause of green tide as well as its growth and drifting characteristics. However, most existing works either rely on single factor analysis or support vector machine-based multifactor analysis that do not have an appropriate mechanism to handle categorical data. In this paper, categorical data analysis is adopted to study the effect of multiple environmental factors to the green algae evolution. Among the five factors we studied, temperature, wind force, and wave height have numerical values but weather condition and wind direction are nominal variables. We focus on the study of the correlation between these environmental factors and the size of distribution area of the green tide. Logistic regression models are built using remote sensing data from the Southern Yellow Sea acquired in 2013. Comprehensive analysis and evaluation are carried out, showing the main factors that affect the size of the bloom to be temperature and wave height, as well as their interaction. We also obtain the influence level of each main factor such that accurate prediction and early warnings of green tide can be made possible to alleviate the damage of the bloom.
SiO2-coated porous anodic alumina membranes for high flow rate electroosmotic pumping

Electroosmotic pumping has been extensively used in lab-on-a-chip devices and micropumps for microelectronic cooling. High flow rate per unit area with a low applied voltage is a key performance requirement to achieve compact design and efficient operation. In this paper, we report work on using SiO2-coated porous anodic alumina membranes for high flow rate electroosmotic pumping under low applied voltages. High quality porous alumina membranes of controllable pore diameters in the range of 30–100 nm and pore lengths of 60–100 µm were fabricated by electrochemical anodization. The pores are straight, uniform and hexagonally close-packed with a high porosity of up to 50% of the total area. The inner surface of the pore was coated conformally with a thin layer (∼5 nm) of SiO2 to achieve a high zeta potential. The electroosmotic pumping performance of the fabricated anodic alumina membranes, coated and uncoated, was investigated using standard relevant aqueous electrolyte buffer solutions. The high zeta potential of the SiO2 coating increases the pumping flow rate even though the coating reduces the porosity of the membrane. Results show that nanostructured SiO2-coated porous anodic alumina membranes can provide a normalized flow rate of 0.125 ml min−1 V−1 cm−2 under a low effective applied voltage of 3 V. This compares favourably with other microporous materials such as glass frits.
Novel glycosaminoglycan mimetic (RGTA, RGD120) contributes to enhance skeletal muscle satellite cell fusion by increasing intracellular Ca2+ and calpain activity

Glycosaminoglycans (GAG) are classes of molecules that play an important role in cellular processes. The use of GAG mimetics called regenerating agent (RGTA) represents a tool to investigate the effect of GAG moiety on cellular behavior. A first member of the RGTA family (RG1192), a dextran polymers with defined amounts of sulfate, carboxymethyl, as well as hydrophobic groups (benzylamide), was shown to stimulate skeletal muscle repair after damage and myoblast differentiation. To obtain a comprehensive insight into the mechanism of action of GAG mimetics, we investigated the effect on myoblast differentiation of a novel RGTA, named RGD120, which was devoid of hydrophobic substitution and had ionic charge similar to heparin. Myoblasts isolated from adult rat skeletal muscles and grown in primary cultures were used in this study. We found that chronic treatment with RGD120 increased the growth of adult myoblasts and induced their precocious fusion into myotubes in vitro. It also partially overcame the inhibitory effect of the calpain inhibitor N‐acetyl‐leu‐leu‐norleucinal (ALLN) on these events. Western blot and zymography analyses revealed that milli calpain was slightly increased by RGD120 chronic treatment. In addition, using fluorescent probes (Indo‐1 and Boc‐leu‐met‐MAC), we demonstrated that RGD120 added to prefusing myoblast cultures accelerates myoblast fusion into myotubes, induced an increase of cytosolic free calcium concentration, and concomitantly an increase of intracellular calpain protease activity. Altogether, these results suggested that the efficiency of RGD120 in stimulating myogenesis might be in part explained through its effect on calcium mobilization as well as on the calpain amount and activity. © 2005 Wiley‐Liss, Inc.