Miracle-dz/UniFAR-FTUs huggingface dataset:
Digging deeper: A holistic perspective of factors affecting soil organic carbon sequestration in agroecosystems

The global magnitude (Pg) of soil organic carbon (SOC) is 677 to 0.3‐m, 993 to 0.5‐m, and 1,505 to 1‐m depth. Thus, ~55% of SOC to 1‐m lies below 0.3‐m depth. Soils of agroecosystems are depleted of their SOC stock and have a low use efficiency of inputs of agronomic yield. This review is a collation and synthesis of articles published in peer‐reviewed journals. The rates of SOC sequestration are scaled up to the global level by linear extrapolation. Soil C sink capacity depends on depth, clay content and mineralogy, plant available water holding capacity, nutrient reserves, landscape position, and the antecedent SOC stock. Estimates of the historic depletion of SOC in world soils, 115–154 (average of 135) Pg C and equivalent to the technical potential or the maximum soil C sink capacity, need to be improved. A positive soil C budget is created by increasing the input of biomass‐C to exceed the SOC losses by erosion and mineralization. The global hotspots of SOC sequestration, soils which are farther from C saturation, include eroded, degraded, desertified, and depleted soils. Ecosystems where SOC sequestration is feasible include 4,900 Mha of agricultural land including 332 Mha equipped for irrigation, 400 Mha of urban lands, and ~2,000 Mha of degraded lands. The rate of SOC sequestration (Mg C ha−1 year−1) is 0.25–1.0 in croplands, 0.10–0.175 in pastures, 0.5–1.0 in permanent crops and urban lands, 0.3–0.7 in salt‐affected and chemically degraded soils, 0.2–0.5 in physically degraded and prone to water erosion, and 0.05–0.2 for those susceptible to wind erosion. Global technical potential of SOC sequestration is 1.45–3.44 Pg C/year (2.45 Pg C/year).
MetaFlow: A Scalable Metadata Lookup Service for Distributed File Systems in Data Centers

In large-scale distributed file systems, efficient metadata operations are critical since most file operations have to interact with metadata servers first. In existing distributed hash table (DHT) based metadata management systems, the lookup service could be a performance bottleneck due to its significant CPU overhead. Our investigations showed that the lookup service could reduce system throughput by up to 70 percent, and increase system latency by a factor of up to 8 compared to ideal scenarios. In this paper, we present MetaFlow, a scalable metadata lookup service utilizing software-defined networking (SDN) techniques to distribute lookup workload over network components. MetaFlow tackles the lookup bottleneck problem by leveraging B-tree, which is constructed over the physical topology, to manage flow tables for SDN-enabled switches. Therefore, metadata requests can be forwarded to appropriate servers using only switches. Extensive performance evaluations in both simulations and testbed showed that MetaFlow increases system throughput by a factor of up to 3.2, and reduce system latency by a factor of up to 5 compared to DHT-based systems. We also deployed MetaFlow in a distributed file system, and demonstrated significant performance improvement.
Effects of erythropoietin and methylprednisolone on AQP4 expression in astrocytes

Methylprednisolone sodium succinate (MPSS) has been suggested as a treatment for spinal cord injury (SCI), but its use has been limited due to its adverse effects. Erythropoietin (EPO) has been suggested as a promising candidate for limiting SCI in mammals. The aim of the present study was to investigate the effects of EPO in combination with MPSS on astrocytes following ischemic injury in vitro. Astrocytes were isolated from the cerebral cortex of postnatal day 3 Sprague-Dawley rats and cultured in vitro. Astrocyte ischemic injury was induced by oxygen and glucose deprivation for 4 h, and reperfusion was simulated by subsequent culture under normoxic conditions. The effects of EPO and MPSS on the expression of aquaporin-4 (AQP4) were investigated. Ischemic astrocytes were treated with EPO (10 U/ml), MPSS (10 µg/ml), or EPO (10 U/ml) in combination with MPSS (10 µg/ml) during reperfusion. The cell viability of astrocytes was assessed using an MTT assay. The mRNA and protein expression levels of AQP4 were determined using reverse transcription-quantitative polymerase chain reaction and western blot analysis, respectively. The role of the protein kinase C (PKC) signaling pathway in the molecular mechanisms underlying the effects of EPO and MPSS was also investigated. The present results demonstrated that following treatment with EPO and MPSS, the mRNA expression levels of AQP4 were upregulated and cell viability was enhanced. EPO and MPSS effectively inhibited the oxygen and glucose deprivation-mediated downregulation of AQP4 following reperfusion. In addition, the combined treatment with EPO and MPSS exhibited higher AQP4 expression levels and cell viability compared with each treatment alone. Finally, the effects of EPO and MPSS on AQP4 expression were partially reversed by pretreatment with the PKC inhibitor Ro 31–8220. The present study indicated that EPO and MPSS had a synergistic effect on AQP4 expression following reperfusion, and suggest that they may be combined in the treatment of SCI.
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA)*

The small molecule CADA was shown to down-modulate the expression of human CD4 in a signal peptide-dependent way through inhibition of its cotranslational translocation across the ER membrane. Previous studies characterizing general glycoprotein levels and the expression of 14 different cell surface receptors showed selectivity of CADA for human CD4. Here, a PowerBlot Western Array was used as a screen to analyze the proteome of CADA-treated SUP-T1 human CD4+ T lymphocytes. This high-throughput monoclonal antibody panel-based immunoblotting assay of cellular signaling proteins revealed that only a small subset of the 444 detected proteins was differentially expressed after treatment with CADA. Validation of these proteomic data with optimized immunoblot analysis confirmed the CADA-induced change in expression of the cell cycle progression regulator pRb2 and the transcription factor c-Jun. However, the up-regulation of pRb2 or down-modulation of c-Jun by CADA had no impact on cell cycle transition. Also, the reduced protein level of human CD4 did not inhibit T cell receptor signaling. Interestingly, the signal peptide-containing membrane protein sortilin was identified as a new substrate for CADA. Both cellular expression and in vitro cotranslational translocation of sortilin were significantly reduced by CADA, although to a lesser extent as compared with human CD4. Our data demonstrate that a small signal peptide-binding drug is able to down-modulate the expression of human CD4 and sortilin, apparently with low impact on the cellular proteome.
Food Processing

Food processing is the transformation of agricultural merchandise into food, or of one form of food into different forms. Food processing consists of many kinds of processing meals from grinding grain to make uncooked flour to domestic cooking to complex commercial strategies used to make comfort meals. Some food processing strategies play essential roles in decreasing meals waste and enhancing food preservation for that reason decreasing the whole environmental effect of agriculture and enhancing food security.
The Influence of Pain Memories on Children’s and Adolescents’ Post-Surgical Pain Experience: A Longitudinal Dyadic Analysis

Objective: Although children’s pain memories have been shown to be a powerful predictor of subsequent pain experiences in acute procedural and experimental pain settings, little is known about the influence of children’s and parents’ pain memories on children’s future pain experiences in other painful contexts. This study used a dyadic approach to examine the roles of children’s and parents’ memories of pain on their subsequent reporting of postsurgical pain several months after the child underwent a major surgical procedure. Method: The sample included 66 parent–child dyads (Mage youth = 14.73 years, SD = 2.01) recruited from 2 tertiary level pediatric hospitals. At baseline, children and parents reported on their catastrophic thinking about the child’s pain. Parent and child reports of child pain were collected at approximately 1 month and 5 months postsurgery. At 2–4 months postsurgery, children’s and parents’ memories for postsurgical pain were assessed. Results: Results revealed that children’s, but not parents’, pain memories were a strong predictor of subsequent pain experienced at 5 months postsurgery. Children’s and parents’ memories for pain did not influence each others’ subsequent pain reporting. Conclusions: Findings suggest that children’s pain memories influence their continued recovery from postsurgical pain and may contribute to pain persistence. Implications for intervention and prevention are discussed.
A new analytical solution for the load-deflection of square membranes

Accurate models are essential for the determination of the elastic properties of thin films from load-deflection experiments. Although finite element method (FEM) models have the potential to be very accurate, analytical models are desirable because of their simplicity. In this paper we present a new analytical solution for the load-deflection of membranes. Our solution yields the same relationship between the load and the deflection as the known analytical solution. However, the values of two constants are up to 35% higher and correspond well with the results from FEM analysis. In addition, the new solution yields analytical forms of the bending lines, which agree well with experimental measurements carried out with silicon nitride membranes.
Rapid 3D mandibular superimposition for growing patients.

OBJECTIVE To evaluate the precision and reproducibility of a protocol to perform rapid voxel-based superimposition of the mandible in growing patients using CBCT. MATERIALS AND METHODS The sample comprised two cone-beam computed tomography scans taken at least 1 year apart from each of 24 growing patients. Voxel-based superimposition was performed by two examiners independently. The internal part of the symphysis extending to the first molar was used as the reference. The superimposition process took approximately 5 minutes. Once the mandibles were superimposed, surface models were created and root mean square (RMS) changes were obtained by means of iterative closest point. To evaluate precision, differences in three areas were measured between time point 1 (T1) and time point 2 (T2) superimposed. To evaluate reproducibility between different examiners, the distances between T2 superimposed by each operator were measured in five different areas. Descriptive statistics were used to evaluate the precision of the superimposition and the interexaminer reproducibility measurements for each case were reported individually. RESULTS The superimposition mean error between T1 and T2 for the right and left sides of the mandible and chin were 0.23 mm, 0.25 mm, and 0.33 mm, respectively. Interexaminer reproducibility error was ≤0.3 mm in 20 of 24 cases for measurements near the registration area. In the ramus area, two cases had errors >1 mm (1 mm-1.3 mm). CONCLUSION The rapid superimposition was precise for assessing dentoalveolar changes and structures close to the registration area. However, evaluation of the condyles and ramus area had limitations and needs improvement.
Understanding the nature of FR II optical nuclei: A new diagnostic plane for radio galaxies

We extend our study of the nuclei of 3CR FR II radio galaxies through HST optical images up to z= 0:3. In the majority of them an unresolved nucleus (central compact core, CCC) is found. We analyze their position in the plane formed by the radio and optical nuclear luminosities in relation to their optical spectral properties. The broad-lined objects (BLO) have the brightest nuclei: they are present only at optical luminositiesL > 410 42 erg s 1 which we suggest might represent a threshold in the radiative eciency combined with a small range of black hole masses. About 40% of the high and low excitation galaxies (HEG and LEG) show CCC which resemble those previously detected in FR I galaxies, in apparent contrast to the unification model. The equivalent width of the (OIII) emission line (with respect to the nuclear luminosity) reveals the nature of these nuclei, indicating that the nuclei of HEG are obscured to our line of sight and only scattered radiation is observed. This implies that the population of FR II is composed of objects with dierent nuclear properties, and only a fraction of them can be unified with quasars.
Codability of industry and occupation information from cancer registry records: Differences by patient demographics, casefinding source, payor, and cancer type

INTRODUCTION Industry and occupation (I&O) information collected by cancer registries is useful for assessing associations among jobs and malignancies. However, systematic differences in I&O availability can bias findings. METHODS Codability by patient demographics, payor, identifying (casefinding) source, and cancer site was assessed using I&O text from first primaries diagnosed 2011-2012 and reported to California Cancer Registry. I&O were coded to a U.S. Census code or classified as blank/inadequate/unknown, retired, or not working for pay. RESULTS Industry was codable for 37% of cases; 50% had "unknown" and 9% "retired" instead of usual industry. Cases initially reported by hospitals, covered by preferred providers, or with known occupational etiology had highest codable industry; cases from private pathology laboratories, with Medicaid, or diagnosed in outpatient settings had least. Occupation results were similar. CONCLUSIONS Recording usual I&O for retirees and improving linkages for reporting entities without patient access would improve I&O codability and research validity.
Coping strategies of nursing students for dealing with university stress Estratégias de coping de acadêmicos de enfermagem diante do estresse universitário Estrategias de afrontamiento de los estudiantes de enfermería diante del estrés universitario

Objective: to identify the coping strategies used by nursing students in a university in southern Brazil, establishing the relationship between the sociodemographic and academic variables examined. Method: an exploratory, descriptive, quantitative study, carried out with 146 nursing students, through application of the Coping Strategies Inventory. For the data analysis, descriptive statistics, analysis of variance and regression analysis were used. Results: it was found that the coping strategy most used by nursing students is escape. A connection was also detected between the academic dissatisfaction variable and the use of negative coping strategies. Conclusion: it was noted that students satisfi ed with the course used positive coping strategies targeting the problem, whereas dissatisfi ed students used negative strategies focusing on the emotion.
Reproductive toxicity of binary and ternary mixture combinations of nickel, zinc, and lead to Ceriodaphnia dubia is best predicted with the independent action model

Metals occur as mixtures in the environment. Risk assessment procedures for metals currently lack a framework to incorporate chronic metal mixture toxicity. In the present study, the toxicity of binary and ternary mixture combinations of Ni, Zn, and Pb was investigated in 3 large‐scale experiments using the standard chronic (7‐d) Ceriodaphnia dubia reproductive toxicity test. These metals were selected because of anticipated differences in mode of action. The toxicity of the metals in most mixtures, expressed as either free metal ion activities or as dissolved metal concentrations, were antagonistic relative to the concentration addition model, whereas no significant (p < 0.05) interactive effects were observed relative to the independent action model. The only exception was the binary Pb–Zn mixture, for which mixture effects were noninteractive based on the dissolved concentrations, but antagonistic based on free ion activities all relative to the independent action model. Overall, the independent action model fitted the observed toxicity better than the concentration addition model, which is consistent with the different modes of action of these metals. The concentration addition model mostly overestimated toxicity. Finally, the present study warns against extrapolation of the type of interactive effects between species, even when they are closely related. Environ Toxicol Chem 2016;35:1796–1805. © 2015 SETAC
How mutation alters the evolutionary dynamics of cooperation on networks

Cooperation is ubiquitous at every level of living organisms. It is known that spatial (network) structure is a viable mechanism for cooperation to evolve. A recently proposed numerical metric, average gradient of selection (AGoS), a useful tool for interpreting and visualizing evolutionary dynamics on networks, allows simulation results to be visualized on a one-dimensional phase space. However, stochastic mutation of strategies was not considered in the analysis of AGoS. Here we extend AGoS so that it can analyze the evolution of cooperation where mutation may alter strategies of individuals on networks. We show that our extended AGoS correctly visualizes the final states of cooperation with mutation in the individual-based simulations. Our analyses revealed that mutation always has a negative effect on the evolution of cooperation regardless of the payoff functions, fraction of cooperators, and network structures. Moreover, we found that scale-free networks are the most vulnerable to mutation and thus the dynamics of cooperation are altered from bistability to coexistence on those networks, undergoing an imperfect pitchfork bifurcation.
Evaluation of the analytical variability of dipstick protein pads in canine urine

BACKGROUND The dipstick is a first-line and inexpensive test that can exclude the presence of proteinuria in dogs. However, no information is available about the analytical variability of canine urine dipstick analysis. OBJECTIVES The aim of this study was to assess the analytical variability in 2 dipsticks and the inter-operator variability in dipstick interpretation. METHODS Canine urine supernatants (n = 174) were analyzed with 2 commercially available dipsticks. Two observers evaluated each result blinded to the other observer and to the results of the other dipstick. Intra- and inter-assay variability was assessed in 5 samples (corresponding to the 5 different semi-quantitative results) tested 10 consecutive times over 5 consecutive days. The agreement between observers and between dipsticks was evaluated with Cohen's k test. RESULTS Intra-assay repeatability was good (≤3/10 errors), whereas inter-assay variability was higher (from 1/5 to 4/5 discordant results). The concordance between the operators (k = 0.68 and 0.79 for the 2 dipsticks) and that of the dipsticks (k = 0.66 and 0.74 for the 2 operators) was good. However, 1 observer and 1 dipstick overestimated the results compared with the second observer or dipstick. In any case, discordant results accounted for a single unit of the semi-quantitative scale. CONCLUSIONS As for any other method, analytic variability may affect the semi-quantitation of urinary proteins when using the dipstick method. Subjective interpretation of the pad and, to a lesser extent, intrinsic staining properties of the pads could affect the results. Further studies are warranted to evaluate the effect of this variability on clinical decisions.
Pulmonary Colonization Resistance to Pathogens via Noncanonical Wnt and Interleukin-17A by Intranasal pep27 Mutant Immunization

Background Previous studies have focused on colonization resistance of the gut microbiota against antibiotic resistant strains. However, less research has been performed on respiratory colonization resistance. Methods Because respiratory colonization is the first step of respiratory infections, intervention to prevent colonization would represent a new approach for preventive and therapeutic measures. The Th17 response plays an important role in clearance of respiratory pathogens. Thus, harnessing the Th17 immune response in the mucosal site would be an effective method to design a respiratory mucosal vaccine. Results In this study, we show that intranasal Δpep27 immunization induces noncanonical Wnt and subsequent interleukin (IL)-17 secretion, and it inhibits Streptococcus pneumoniae, Staphylococcus aureus, and Klebsiella pneumoniae colonization. Moreover, IL-17A neutralization or nuclear factor of activated T-cell inhibition augmented bacterial colonization, indicating that noncanonical Wnt signaling is involved in pulmonary colonization resistance. Conclusions Therefore, Δpep27 immunization can provide nonspecific respiratory colonization resistance via noncanonical Wnt signaling and IL-17A-related pathways.
Distributed target identification in robotic swarms

The ability to identify the target of a common action is fundamental for the development of a multi-robot team able to interact with the environment. In most existing systems, the identification is carried on individually, based on either color coding, shape identification or complex vision systems. Those methods usually assume a broad point of view over the objects, which are observed in their entirety. This assumption is sometimes difficult to fulfill in practice, and in particular in swarm systems, constituted by a multitude of small robots with limited sensing and computational capabilities. In this paper, we propose a method for target identification with a heterogeneous swarm of low-informative spatially-distributed sensors employing a distributed version of the naive Bayes classifier. Despite limited individual sensing capabilities, the recursive application of the Bayes law allows the identification if the robots cooperate sharing the information that they are able to gather from their limited points of view. Simulation results show the effectiveness of this approach highlighting some properties of the developed algorithm.
Detecting Changes in Newspaper Reporting of Suicide after a Statewide Social Marketing Campaign

ABSTRACT A social marketing campaign was introduced in California in 2012, promoting media adherence to consensus-based guidelines on reporting about suicide. We examine adherence to these guidelines by applying quantitative scores to articles in California and a national control group in two six-month intervals prior to and following campaign implementation. Utilizing a difference-in-difference approach, we found no significant effect of the campaign, though the type of article content was a significant indicator of the overall score. Findings also demonstrated a nation-wide downward trend in the quality of reporting. Qualitative results suggest a need for more flexible guidelines in light of a technologically driven news culture.