Miracle-dz/UniFAR-FTUs huggingface dataset:
Teachers’ Perceptions of their Preparation for Teaching Linguistically and Culturally Diverse Learners in Rural Eastern North Carolina

The number of English language learners (ELL) students in the US is increasing dramatically. The growth is even more evident in rural areas of the United States such as North Carolina where teachers are facing classrooms with a majority of second language learners. The authors conducted a study interviewing 24 teachers at a rural elementary school in eastern North Carolina. Teachers were interviewed regarding their perceptions of their preparedness to teach English language learners in the mainstream classrooms. Findings revealed that teacher training programs have not prepared these individuals for the student population they face today regardless of the year in which they received their teaching licenses. All teachers showed a strong desire to learn more at this time in their careers, but emphasized their lack of prior training. The study found that even though teachers lacked confidence, they were effectively educating this growing population. The authors discuss the responsibility of Institutions of Higher Education (IHE) to provide formal education in teaching students from diverse language backgrounds.
A λ 3 mm and 1 mm line survey toward the yellow hypergiant IRC +10420: N-rich chemistry and IR flux variations.

AIMS Our knowledge of the chemical properties of the circumstellar ejecta of the most massive evolved stars is particularly poor. We aim to study the chemical characteristics of the prototypical yellow hypergiant star, IRC +10420. For this purpose, we obtained full line surveys at 1 and 3 mm atmospheric windows. METHODS We have identified 106 molecular emission lines from 22 molecular species. Approximately half of the molecules detected are N-bearing species, in particular HCN, HNC, CN, NO, NS, PN, and N2H+. We used rotational diagrams to derive the density and rotational temperature of the different molecular species detected. We introduced an iterative method that allows us to take moderate line opacities into account. RESULTS We have found that IRC +10420 presents high abundances of the N-bearing molecules compared with O-rich evolved stars. This result supports the presence of a N-rich chemistry, expected for massive stars. Our analysis also suggests a decrease of the 12C/13C ratio from ≳ 7 to ~ 3.7 in the last 3800 years, which can be directly related to the nitrogen enrichment observed. In addition, we found that SiO emission presents a significant intensity decrease for high-J lines when compared with older observations. Radiative transfer modeling shows that this variation can be explained by a decrease in the infrared (IR) flux of the dust. The origin of this decrease might be an expansion of the dust shell or a lower stellar temperature due to the pulsation of the star.
Establishment of stem cell identity in the Drosophila germline

In the adult Drosophila ovary the continuous production of eggs depends upon a small group of stem cells located at the anterior tip of the germarium. These stem cells divide asymmetrically to self renew and to generate a cystoblast, which in females is committed to the oocyte differentiation pathway. While much is known about the development of poststem cell cystoblasts, little is known about when stem cells are formed or how their identity is initially established. To investigate these questions we have used the P‐M hybrid dysgenesis syndrome as a tool for ablating the “pre‐stem cell” progenitors of the stem cells. Our experiments indicate that the pre‐stem cells in females assume stem cell identity during the early pupal stage. Our results also suggest a model in which at least two prestem cells must be present within an ovariole for the specification of stem cell fate. When only a single pre‐stem cell is sequestered by an ovariole, this cell does not assume stem cell identity, but instead follows the cystoblast‐cystocyte differentiation pathway. Dev. Dyn. 1997;210:371–382. © 1997 Wiley‐Liss, Inc.
Mitochondrial DNA A4336G Mutation in Alzheimer’s and Parkinson’s Diseases

Objectives: To determine whether the mitochondrial DNA (mtDNA) A4336G mutation represents a risk factor for Spanish patients with both Alzheimer’s disease (AD) and Parkinson’s disease (PD). Material and Methods: One hundred and sixty-one AD and 106 PD unrelated patients were included in the study. Seventy-eight age-matched and 144 randomly chosen healthy subjects served as controls. The frequency of the A4336G mutation in these groups was compared using the χ2 and Fisher’s exact tests. p < 0.05 was established as a statistically significant differential value. Results: The mtDNA A4336G mutation was present in 1/161 of AD patients (0.6%), in 3/106 of PD patients (2.8%), in 1/78 of age-matched controls (1.3%) and in 2/144 of the randomly chosen controls (1.4%). These differences were not statistically significant. Conclusion: Our results do not support the hypothesis that this mutation represents a risk factor for either AD or PD patients, at least in the case of this Spanish sample.
Nobody in charge: Distributed change agency in healthcare

This article illustrates how distributed change agency can implement complex organizational changes in the absence of formal management plans, roles, and structures. Distributed change agency typically involves small teams and senior groups. In this qualitative study of service improvements in the treatment of prostate cancer at an acute hospital, Grange, change roles were distributed more widely, with responsibilities `migrating' among a large informal cast supporting four central characters. This distribution appears to have been triggered by the change goals and substance, and by the network organization through which services were delivered. Cross-case comparisons with other hospitals, Henley and Norwood, suggest that a combination of factors contributed to the development of a distributed approach. Analytical generalization invites speculation concerning the transferability of this model, with `nobody in charge', to other settings. One policy implication concerns the provision of development in change agency competencies to staff other than those in senior positions.
[Etiology and occurrence of periodic eye inflammation of horses in the area of Berlin].

Over 130 cases of equine periodic ophthalmia (p.o.), which were treated as in-patients at the Equine Clinic of the Free University of Berlin in the last 35 years, were examined statistically in relation to the age and gender of the animals involved as well as to the development of the illness and the season in which it arose. As regards aetiology, the extraction of 71 affected Trotters was investigated. Antibodies to toxoplasmosis, leptospirosis and intestinal parasites were found only in some of the patients. Younger animals, aged between one and four years, and male animals (63.6%) were predominantly affected. The results of the examinations of faeces showed no correlation between cases of p.o. and a vermination of the horses. The examinations for antibodies to toxoplasmosis gave no indication of a participation of the toxoplasmas in the aetiology of recurrent uveitis. In contrast, the results of the examinations for antibodies to leptospirosis, of which 58.8% were positive, showed a seven to ten times higher infection than in healthy horses in Berlin. Breed analysis showed that in certain breeds of Trotters and warm-blooded horses, p.o. illnesses were frequent, supporting the hypothesis that the occurrence of p.o. is due to a hereditary, allergic reaction, triggered by various factors, in particular an infection without clinical signs.
STAX: Statistical Crosstalk Target Set Compaction

This paper presents STAX, a crosstalk target set compaction framework to reduce the complexity of the crosstalk ATPG process by pruning non-fault-producing targets. In general, existing pruning techniques do not employ their processes in a cost-effective manner. Neither do they handle process variations properly. To address the first weakness, this paper presents a framework to determine a sequence of available analysis and pruning tool invocations to prune as many of the crosstalk targets as fast as possible. As a result, an initially enormous collection of crosstalk targets is usually reduced to a very small set of targets via a vectorless process. A statistical static timing analyzer is developed and embedded to address the second shortcoming of existing approaches. Experimental results on ISCAS'85 benchmark demonstrate that STAX greatly improves the runtime compared to other crosstalk target pruning methodologies, including ATPG, with no prior target set compaction
Representation and recognition of human actions in video

Automated human action recognition plays a critical role in the development of human-machine communication, by aiming for a more natural interaction between artificial intelligence and the human society. Recent developments in technology have permitted a shift from a traditional human action recognition performed in a well-constrained laboratory environment to realistic unconstrained scenarios. This advancement has given rise to new problems and challenges still not addressed by the available methods. Thus, the aim of this thesis is to study innovative approaches that address the challenging problems of human action recognition from video captured in unconstrained scenarios. To this end, novel action representations, feature selection methods, fusion strategies and classification approaches are formulated. More specifically, a novel interest points based action representation is firstly introduced, this representation seeks to describe actions as clouds of interest points accumulated at different temporal scales. The idea behind this method consists of extracting holistic features from the point clouds and explicitly and globally describing the spatial and temporal action dynamic. Since the proposed clouds of points representation exploits alternative and complementary information compared to the conventional interest points-based methods, a more solid representation is then obtained by fusing the two representations, adopting a Multiple Kernel Learning strategy. The validity of the proposed approach in recognising action from a well-known benchmark dataset is demonstrated as well as the superior performance achieved by fusing representations. Since the proposed method appears limited by the presence of a dynamic background and fast camera movements, a novel trajectory-based representation is formulated. Different from interest points, trajectories can simultaneously retain motion and appearance information even in noisy and crowded scenarios. Additionally, they can handle drastic camera movements and a robust region of interest estimation. An equally important contribution is the proposed collaborative feature selection performed to remove redundant and noisy components. In particular, a novel feature selection method based on Multi-Class Delta Latent Dirichlet Allocation (MC-∆LDA) is introduced. Crucial, to enrich the final action representation, the trajectory representation is
Major depression and cigarette smoking: results of a 21-year longitudinal study

Background. The aim of this paper was to examine the association between major depression and cigarette smoking among young adults in a birth cohort before and after adjusting for confounding factors. Method. Data were gathered over the course of the Christchurch Health and Development Study (CHDS). The CHDS is a longitudinal study of a birth cohort of 1265 New Zealand children studied to age 21. Data were gathered by interview on: (a) major depression over the period 16–21 years; (b) daily smoking and nicotine dependence over the period from 16–21 years. In addition, the study included extensive information on social, family, and behavioural factors in childhood and adolescence. Results. Young people meeting DSM-IV criteria for major depression had elevated rates of daily smoking and nicotine dependence. These associations were reduced substantially by control for potential confounding child and adolescent factors. Nonetheless, even after such control, major depression was associated with increased rates of daily smoking (IRR=1·19; 95% CI=1·03, 1·39) and elevated rates of nicotine dependence (OR=1·75; 95% CI=1·13, 2·70). Conclusions. The results suggest that much of the association between smoking and depression reflects common confounding factors that are associated with both outcomes. Nonetheless, even after control for these factors there is evidence of a possible causal linkage between smoking and depression. The direction of causality between smoking and depression remains unknown.
In-group bias in response to an organizational merger

The present research examined the extent of in-group bias in response to a planned organizational merger. Data were collected from 1,104 employees of 2 hospitals intending to merge - a high-status metropolitan teaching hospital and a relatively low-status local area hospital. As predicted from social identity theory, there was clear evidence of in-group bias, particularly among the employees of the lower status hospital on the dimensions irrelevant to the status differentiation between hospitals. On the status-relevant dimensions, in-group bias was significantly more marked among the employees of the high-status hospital. Also, as predicted, perceived threat was related to in-group bias on the status-irrelevant dimensions among the low-status employees. The present results indicate that managers need to be cognizant of the intergroup rivalry that is likely to be engendered in the context of an organizational merger, particularly among the employees of the lower status organization. Copyright 1998 by the Educational Publishing Foundation.
Vicarious intergroup contact effects

This contribution examines the role of vicarious contact (observing in-group members having successful cross-group contact) as a tool to improve intergroup relations. Expanding previous research on indirect intergroup contact, vicarious contact (1) integrates and applies concepts of social-cognitive theory (Bandura, 1986) to the field of intergroup contact research; (2) broadens the study of indirect contact effects to the observation of successful cross-group interactions; and (3) proposes to increase people’s intention for direct cross-group contact. Two video-based experiments indicate that vicarious contact improves attitudes towards the out-group and increases participants’ willingness to engage in direct cross-group contact. These studies provide evidence that the relation between vicarious contact and intergroup attitudes (and willingness to engage in direct contact) is sequentially mediated by self-efficacy expectancy and perceived intergroup uncertainty. Implications of these findings for further research on the (indirect) contact hypothesis and their application will be discussed.
Further Investigating Method Effects Associated With Negatively Worded Items on Self-Report Surveys

This article used multitrait-multimethod methodology and covariance modeling for an investigation of the presence and correlates of method effects associated with negatively worded items on the Rosenberg Self-Esteem (RSE) scale (Rosenberg, 1989) using a sample of 757 adults. Results showed that method effects associated with negative item phrasing on the RSE scale were present. Method effects associated with negative item wording were similarly observed with the Social Physique Anxiety Scale (SPAS; Hart, Leary, & Rejeski, 1989) and method effects were present and significantly correlated in analyses that included both the RSE scale and SPAS simultaneously. Path analysis modeling that incorporated personality measures identified factors that correlated with the presence of method effects. These findings further suggest that method effects associated with negatively worded items may be considered a response style.
Identity, choice and consumer freedom – the new opiates? A psychoanalytic interrogation

Psychoanalysis opens a variety of windows into understanding contemporary consumption and consumerism. The psychoanalytic theory of defence and the unconscious enables us to understand why commodities, from fast cars to luxury chocolate, so readily stand in to offer substitute gratification for deeper repressed desires and why the meaning of such commodities is liable to become mobile and unstable (Baudrillard, 1988 [1970]). The psychoanalytic concepts of narcissism (Freud, 1914) and the mirror stage (Lacan, 2006) provide powerful entry points into understanding our culture’s obsession with image (Cluley and Dunne, 2012), whilst the theory of neurosis offers significant insights into the addictive and deeply irrational qualities of contemporary consumption (Lasch, 1980). Object relations theory (Winnicott, 1964) enables us to understand how material objects, from early childhood attachments to teddy bears, act as bridges between our sense of self and what we come to view as an external world deeply indifferent to our desires. Several other psychoanalytic concepts and ideas have proven particularly helpful in contemporary discourses on consumption. This essay draws its inspiration from Freud’s theory of religion (Freud,1927, 1930) to test the view that the consumer’s freedom to choose and construct an identity is an illusion in the technical sense – a fantasy that discloses deeper desires and offers substitute gratifications for the discontents inflicted on us by contemporary consumer culture. Like earlier illusions, the illusion of freedom and the derivative illusions of choice and identity may provide some consolation, but, arguably, then deepen the discontents for which they purport to offer comfort.
Prognostic value of inflammatory markers (notably cytokines and procalcitonin), nutritional assessment, and organ function in patients with sepsis.

OBJECTIVE Procalcitonin is useful for the diagnosis of sepsis, but its prognostic value regarding mortality is unclear. Our objective was to determine the prognostic value of procalcitonin determined at the onset of sepsis, and to compare it with other markers of inflammatory response, malnutrition and organ dysfunction data. METHODS We studied 253 hospitalized patients (146 men, 107 women) with a median age of 65 years. Sepsis was defined as infection, and at least two SIRS criteria. We assessed co-morbidities, nutritional status, bacteremia, procalcitonin and other inflammatory markers (PCR, TNF-alpha, IL6, TREM-1, IL-10, IL-1ra, CD14 and LBP), and organ function using the SOFA score. Mortality was assessed at 28 days after onset of sepsis. RESULTS At day 28, 49 (19%) patients had died. Inflammatory markers showed only moderate predictive value for mortality, with IL-10 and IL-6 being the best predictors. Mortality was mainly related to organ dysfunction indicators (SOFA and Glasgow scores), serum lactate, ferritin and LDH levels, and to nutritional data such as subjective assessment, handgrip strength and serum transferrin levels. The most frequent location of sepsis was the lung, with 140 cases (55%), which showed more comorbidity, worse nutritional status, less frequent bacteremia and lower inflammatory response. When the analysis was limited to patients with non-pulmonary sepsis, organ dysfunction, nutritional status and inflammatory markers showed the best prognostic value. Of the inflammatory markers, procalcitonin showed only moderate predictive value; however it showed the highest correlation with bacteremia and the ability to discriminate non-complicated sepsis from severe forms. CONCLUSION Procalcitonin only showed moderate predictive value for sepsis-related mortality, being surpassed by organ dysfunction, nutritional status, IL-10 and IL-6. However, it proved useful to discriminate between non-complicated and severe forms of sepsis.
Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD.

BACKGROUND AND OBJECTIVES Roxadustat (FG-4592), an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis, regulates iron metabolism, and reduces hepcidin, was evaluated in this phase 2b study for safety, efficacy, optimal dose, and dose frequency in patients with nondialysis CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The 145 patients with nondialysis CKD and hemoglobin ≤10.5 g/dl were randomized into one of six cohorts of approximately 24 patients each with varying roxadustat starting doses (tiered weight and fixed amounts) and frequencies (two and three times weekly) followed by hemoglobin maintenance with roxadustat one to three times weekly. Treatment duration was 16 or 24 weeks. Intravenous iron was prohibited. The primary end point was the proportion of patients achieving hemoglobin increase of ≥1.0 g/dl from baseline and hemoglobin of ≥11.0 g/dl by week 17 (16 weeks of treatment). Secondary analyses included mean hemoglobin change from baseline, iron utilization, and serum lipids. Safety was evaluated by frequency/severity of adverse events. RESULTS Of the 145 patients enrolled, 143 were evaluable for efficacy. Overall, 92% of patients achieved hemoglobin response. Higher compared with lower starting doses led to earlier achievement of hemoglobin response. Roxadustat-induced hemoglobin increases were independent of baseline C-reactive protein levels and iron repletion status. Overall, over the first 16 treatment weeks, hepcidin levels decreased by 16.9% (P=0.004), reticulocyte hemoglobin content was maintained, and hemoglobin increased by a mean (±SD) of 1.83 (±0.09) g/dl (P<0.001). Overall mean total cholesterol level was reduced by a mean (±SD) of 26 (±30) mg/dl (P<0.001) after 8 weeks of therapy, independent of the use of statins or other lipid-lowering agents. No drug-related serious adverse events were reported. CONCLUSIONS In patients with nondialysis CKD who were anemic, various starting dose regimens of roxadustat were well tolerated and achieved anemia correction with reduced serum hepcidin levels. After anemia correction, hemoglobin was maintained by roxadustat at various dose frequencies without intravenous iron supplementation.
Building Psychological Capital With Appreciative Inquiry

Appreciative Inquiry (AI) is growing in popularity as a strength-based approach to organization and whole system development. Despite numerous accounts on AI’s outcomes positively impacting on organizations and persons, a dearth of quantitative studies exists measuring AI’s impact on individual-level outcomes. This quantitative study investigates how participating in AI impacts on individuals’ psychological capital (PsyCap) through fulfilling their basic psychological needs (BPN) for competence, autonomy, and relatedness. Results, based on data from 213 participants who worked in social profit organizations and either belonged to a group with AI experience or without AI experience, indicate that satisfying the need for competence mediates the relationship between participating in AI and the PsyCap dimensions self-efficacy, optimism, resilience, and hope. Furthermore, results show that participating in AI satisfies the three BPN. Next to theoretical implications, the article provides insights into how leaders of change can build organizations in which people thrive.