Miracle-dz/UniFAR-FTUs huggingface dataset:
Margin-Maximizing Feature Elimination Methods for Linear and Nonlinear Kernel-Based Discriminant Functions

Feature selection for classification in high-dimensional spaces can improve generalization, reduce classifier complexity, and identify important, discriminating feature ¿markers. ¿ For support vector machine (SVM) classification, a widely used technique is recursive feature elimination (RFE). We demonstrate that RFE is not consistent with margin maximization, central to the SVM learning approach. We thus propose explicit margin-based feature elimination (MFE) for SVMs and demonstrate both improved margin and improved generalization, compared with RFE. Moreover, for the case of a nonlinear kernel, we show that RFE assumes that the squared weight vector 2-norm is strictly decreasing as features are eliminated. We demonstrate this is not true for the Gaussian kernel and, consequently, RFE may give poor results in this case. MFE for nonlinear kernels gives better margin and generalization. We also present an extension which achieves further margin gains, by optimizing only two degrees of freedom-the hyperplane's intercept and its squared 2-norm-with the weight vector orientation fixed. We finally introduce an extension that allows margin slackness. We compare against several alternatives, including RFE and a linear programming method that embeds feature selection within the classifier design. On high-dimensional gene microarray data sets, University of California at Irvine (UCI) repository data sets, and Alzheimer's disease brain image data, MFE methods give promising results.
Feature Subset Selection as Search with Probabilistic Estimates

Irrelevant features and weakly relevant features may reduce the comprehensibility and accuracy of concepts induced by supervised learning algorithms. We formulate the search for a feature subset as an abstract search problem with probabilistic estimates. Searching a space using an evaluation function that is a random variable requires trading off accuracy of estimates for increased state exploration. We show how recent feature subset selection algorithms in the machine learning literature fit into this search problem as simple hill climbing approaches, and conduct a small experiment using a best-first search technique.
Sociodemographic and health factors associated with chronic pain in institutionalized elderly

OBJECTIVES: to characterize chronic pain in institutionalized elderly and verify the associated factors. METHOD: observational, cross-sectional and non-experimental study with a quantitative approach. The study participants were 124 elderly living in Long-Term Care Institutions for the Elderly (LTCIs) in a city in Minas Gerais (Brazil). Approval for the project was obtained from the Research Ethics Committee. The elderly's clinical and sociodemographic variables and pain-related aspects were assessed. The data were analyzed through descriptive statistics and bivariate analysis (chi-squared). RESULTS: the prevalence of chronic pain corresponded to 58.1%; for more than 10 years (26.4%); in lower limbs (31.9%); characterized as "twinges" (33.3%); 33.3% adopted medication treatment; the pain did not improve (41.7 %); or worsen (34.7 %). It was evidenced that elderly aged 60├ 70 old had 70% less chances of chronic pain than those aged 80 years and older (p=0.018). CONCLUSION: institutionalized elderly have a high prevalence of chronic pain, mainly in the lower limbs. No factors of pain improvement or worsening were identified and medication was evidenced as the preferred treatment. Age showed to be associated with the presence of pain. It is considered important to accomplish multiprofessional actions at the LTCIs to guide prevention and rehabilitation actions of the pain episodes in these elderly.
Environmental Regulation and Trade Flows

Should international trade agreements be extended to include negotiations over environmental policy? The answer depends on whether countries distort levels of environmental regulations as a secondary means of providing protection to domestic industries; our results suggest that they do. Previous studies of this relationship have treated the level of environmental regulation as exogenous, and found a negligible correlation between environmental regulation and trade ows. In contrast, we nd that, when the level of environmental regulation is modeled as an endogenous variable, its estimated e ect on trade ows is signi cantly higher than previously reported. JEL code: F13 (Commerical Policy, Protection, Promotion, Trade Negotiations)
A linear-time algorithm for a special case of disjoint set union

This paper presents a linear-time algorithm for the special case of the disjoint set union problem in which the structure of the unions (defined by a “union tree”) is known in advance. The algorithm executes an intermixed sequence of m union and find operations on n elements in 0(m+n) time and 0(n) space. This is a slight but theoretically significant improvement over the fastest known algorithm for the general problem, which runs in 0(m&agr;(m+n, n)+n) time and 0(n) space, where &agr; is a functional inverse of Ackermann's function. Used as a subroutine, the algorithm gives similar improvements in the efficiency of algorithms for solving a number of other problems, including two-processor scheduling, the off-line min problem, matching on convex graphs, finding nearest common ancestors off-line, testing a flow graph for reducibility, and finding two disjoint directed spanning trees. The algorithm obtains its efficiency by combining a fast algorithm for the general problem with table look-up on small sets, and requires a random access machine for its implementation. The algorithm extends to the case in which single-node additions to the union tree are allowed. The extended algorithm is useful in finding maximum cardinality matchings on nonbipartite graphs.
Molecular Recognition of Taxol by Microtubules

We have determined the kinetic scheme and the reaction rates of binding to microtubules of two fluorescent taxoids, 7-O-[N-(4′-fluoresceincarbonyl)-l-alanyl]Taxol (Flutax-1) and 7-O-[N-(2,7-difluoro-4′-fluoresceincarbonyl)-l-alanyl]Taxol (Flutax-2). Flutax-1 and Flutax-2 bind to microtubules with high affinity (K a ≈ 107 m − 1, 37 °C). The binding mechanism consists of a fast bimolecular reaction followed by at least two monomolecular rearrangements, which were characterized with stopped-flow techniques. The kinetic constants of the bimolecular reaction were 6.10 ± 0.22 × 105 m − 1 s− 1and 13.8 ± 1.8 × 105 m − 1 s− 1at 37 °C, respectively. A second slow binding step has been measured employing the change of fluorescence anisotropy of the probe. The reversal of this reaction is the rate-limiting step of dissociation. A third step has been detected using small angle x-ray scattering and involves a 2-nm increase in the diameter of microtubules. It is suggested that the first step entails the binding of the Taxol moiety and the second a relative immobilization of the fluorescent probe. The equilibrium and some kinetic measurements required the use of stabilized cross-linked microtubules, which preserved taxoid binding. The results indicate that the Taxol binding site is directly accessible, in contrast with its location at lumen in the current model of microtubules. An alternative structural model is considered in which the binding site is located between protofilaments, accessible from the microtubule surface.
Functional mapping of ontogeny in flowering plants

All organisms face the problem of how to perform a sequence of developmental changes and transitions during ontogeny. We revise functional mapping, a statistical model originally derived to map genes that determine developmental dynamics, to take into account the entire process of ontogenetic growth from embryo to adult and from the vegetative to reproductive phase. The revised model provides a framework that reconciles the genetic architecture of development at different stages and elucidates a comprehensive picture of the genetic control mechanisms of growth that change gradually from a simple to a more complex level. We use an annual flowering plant, as an example, to demonstrate our model by which to map genes and their interactions involved in embryo and postembryonic growth. The model provides a useful tool to study the genetic control of ontogenetic growth in flowering plants and any other organisms through proper modifications based on their biological characteristics.
No Ifs, Ands, or Buts Uncovering the Simplicity of Conditionals

Schematic tables are a new representation for conditionals. Roughly a cross between decision tables and data ﬂow graphs, they represent computation and decision-making orthogonally. They unify the full range of conditional constructs, from if statements through pattern matching to polymorphic predicate dispatch. Program logic is maintained in a declarative canonical form that enforces completeness and disjointness among choices. Schematic tables can be used either as a code speciﬁcation/generation tool, or as a self-contained diagrammatic programming language. They give program logic the clarity of truth tables, and support high-level direct manipulation of that logic, avoiding much of the mental computation demanded by conventional conditionals.
The effect of foot-rest position on the strength of horizontal pull by the hand.

Abstract : An investigation was conducted to determine the effect of foot-rest position on the strength of horizontal pull by the hand at four different elbow angles. At all elbow-angles the strength of hand pull increased as the thigh was elevated above the horizontal or as the leg was straightened. The effect of foot-rest position on output increased as the arm was straightened. The knee- angle exerted a greater effect on the strength of the hand movement than did the thigh-angle. The results were in agreement with the hypothesis that the strength of hand pull is greatest when the legs are in the position at which they can exert the greatest force against the foot-rest. The force developed by the legs tends to counteract the force exerted by the hand and thus limits the strength of hand pull. In order to maximize the strength of horizontal pull by the hand, the foot-rest should be in such a position as to produce a thigh-angle of approximately 20 degrees above the horizontal and a knee-angle of approximately 150 degrees. The foot-rest position is important even at comparatively low output levels.
What is the limit of climate engineering by stratospheric injection of SO 2

Abstract. The injection of sulfur dioxide (SO2) into the stratosphere to form an artificial stratospheric aerosol layer is discussed as an option for solar radiation management. The related reduction of radiative forcing depends upon the injected amount of sulfur dioxide, but aerosol model studies indicate a decrease in forcing efficiency with increasing injection rate. None of these studies, however, consider injection rates greater than 20 Tg(S) yr−1. But this would be necessary to counteract the strong anthropogenic forcing expected if "business as usual" emission conditions continue throughout this century. To understand the effects of the injection of larger amounts of SO2, we have calculated the effects of SO2 injections up to 100 Tg(S) yr−1. We estimate the reliability of our results through consideration of various injection strategies and from comparison with results obtained from other models. Our calculations show that the efficiency of such a geoengineering method, expressed as the ratio between sulfate aerosol forcing and injection rate, decays exponentially. This result implies that the sulfate solar radiation management strategy required to keep temperatures constant at that anticipated for 2020, while maintaining business as usual conditions, would require atmospheric injections of approximately 45 Tg(S) yr−1 (±15 % or 7 Tg(S) yr−1) at a height corresponding to 60 hPa. This emission is equivalent to 5 to 7 times the Mt. Pinatubo eruption each year.
On a problem posed by Steve Smale

The 17th of the problems proposed by Steve Smale for the 21st century asks for the existence of a deterministic algorithm computing an approximate solution of a system of n complex polynomials in n unknowns in time polynomial, on the average, in the size N of the input system. A partial solution to this problem was given by Carlos Beltr an and Luis Miguel Pardo who exhibited a randomized algorithm doing so. In this paper we further extend this result in several directions. Firstly, we exhibit a linear homotopy algorithm that eciently implements a nonconstructive idea of
Association of parathyroid adenoma and pregnancy with preeclampsia.

OBJECTIVE Case reports have described associations between calcium metabolism disturbances and primary hyperparathyroidism with preeclampsia, suggesting parathyroid involvement in preeclampsia etiology. This study examines whether parathyroid adenoma, the main cause of hyperparathyroidism, diagnosed and treated before pregnancy is associated with preeclampsia. DESIGN We conducted a register-based study to assess the association between parathyroid adenoma and subsequent preeclampsia. SETTING Births among Sweden's general population were studied. POPULATION The study population included 52 women with a diagnosis of parathyroid adenoma and 519 without, all of whom had a subsequent singleton pregnancy between 1973 and 1997. METHODS We performed a conditional logistic regression investigating the association of parathyroid adenoma with subsequent preeclampsia in the first singleton pregnancy with adjustment for potential confounding factors. MAIN OUTCOME MEASURE The main outcome was a diagnosis of preeclampsia that does not include women with prior chronic hypertension. To ensure that treatment of parathyroid adenoma was completed before pregnancy, those with a diagnosis of parathyroid adenoma made less than 2 yr before delivery (and the matched comparison women) were excluded. RESULTS Statistically, parathyroid adenoma prior to delivery is significantly (P < 0.001) associated with preeclampsia, producing an adjusted odds ratio of 6.89 (95% confidence interval, 2.30, 20.58). CONCLUSION A history of parathyroid adenoma should be viewed as a risk for preeclampsia.
A 70‐Kilodalton Microtubule‐Associated Protein (MAP2c), Related to MAP2

Microtubule‐associated protein 2 (MAP2) from adult brain consists of a pair of high molecular mass (280 kilodaltons) polypeptides, MAP2a and MAP2b. Juvenile brain microtubules also contain a 70‐kilodalton protein that cross‐reacts with monoclonal antibodies against these high molecular weight MAP2s. We have analyzed the relationship between this 70‐kilodalton protein and MAP2 by peptide mapping. Our results show that the 70‐kilodalton species bears strong homology to the MAP2 molecules and that it is distinct from the t MAPs. We propose the name MAP2c for this low molecular weight MAP2 species. MAP2c is developmentally regulated in brain, being more abundant in neonatal tissue than in the adult. In several cell lines, MAP2c is the sole MAP2 species expressed. We examined homogenates from both juvenile brain and MAP2c‐containing cell lines for evidence of a protease activity that might be responsible for generating MAP2c from either MAP2a or MAP2b. No such activity was found, suggesting that MAP2c is an independently synthesized MAP2 species some 200 kilodaltons smaller than the previously recognized forms.
A Nasal Interleukin-12 DNA Vaccine Coexpressing Yersinia pestis F1-V Fusion Protein Confers Protection against Pneumonic Plague

ABSTRACT Previous studies have shown that mucosal application of interleukin-12 (IL-12) can stimulate elevated secretory immunoglobulin A (IgA) responses. Since possible exposure to plague is via Yersinia pestis-laden aerosols that results in pneumonic plague, arming both the mucosal and systemic immune systems may offer an added benefit for protective immunity. Two bicistronic plasmids were constructed that encoded the protective plague epitopes, capsular antigen (F1-Ag) and virulence antigen (V-Ag) as a F1-V fusion protein but differed in the amounts of IL-12 produced. When applied nasally, serum IgG and mucosal IgA anti-F1-Ag and anti-V-Ag titers were detectable beginning at week 6 after three weekly doses, and recombinant F1-Ag boosts were required to elevate the F1-Ag-specific antibody (Ab) titers. Following pneumonic challenge, the best efficacy was obtained in mice primed with IL-12(Low)/F1-V vaccine with 80% survival compared to mice immunized with IL-12(Low)/F1, IL-12(Low)/V, or IL-12(Low) vector DNA vaccines. Improved expression of IL-12 resulted in lost efficacy when using the IL-12(High)/F1-V DNA vaccine. Despite differences in the amount of IL-12 produced by the two F1-V DNA vaccines, Ab responses and Th cell responses to F1- and V-Ags were similar. These results show that IL-12 can be used as a molecular adjuvant to enhance protective immunity against pneumonic plague, but in a dose-dependent fashion.
LTE security, protocol exploits and location tracking experimentation with low-cost software radio

The Long Term Evolution (LTE) is the latest mobile standard being implemented globally to provide connectivity and access to advanced services for personal mobile devices. Moreover, LTE networks are considered to be one of the main pillars for the deployment of Machine to Machine (M2M) communication systems and the spread of the Internet of Things (IoT). As an enabler for advanced communications services with a subscription count in the billions, security is of capital importance in LTE. Although legacy GSM (Global System for Mobile Communications) networks are known for being insecure and vulnerable to rogue base stations, LTE is assumed to guarantee confidentiality and strong authentication. However, LTE networks are vulnerable to security threats that tamper availability, privacy and authentication. This manuscript, which summarizes and expands the results presented by the author at ShmooCon 2016 \cite{jover2016lte}, investigates the insecurity rationale behind LTE protocol exploits and LTE rogue base stations based on the analysis of real LTE radio link captures from the production network. Implementation results are discussed from the actual deployment of LTE rogue base stations, IMSI catchers and exploits that can potentially block a mobile device. A previously unknown technique to potentially track the location of mobile devices as they move from cell to cell is also discussed, with mitigations being proposed.
Implementation of High-Power-Density  $X$ -Band AlGaN/GaN High Electron Mobility Transistors in a Millimeter-Wave Monolithic Microwave Integrated Circuit Process

A GaN high electron mobility transistor monolithic microwave integrated circuit (MMIC) designer typically has to choose a device design either for high-gain millimeter-wave operation with a short gate length, or for high-power-density X-band operation with a much larger gate/field-plate structure. We provide the designer the option of incorporating two different devices by implementing a 0.14-μm gate length GaN MMIC process capable of high-efficiency Ka-band operation while simultaneously achieving high power density in the same process flow. The key process enabler simply uses the capacitor top plate in the MMIC process as a field plate on the passivation layer. On two separate devices on the same chip using the same MMIC process flow, we demonstrate 7.7 W/mm at 35 GHz and VDS = 30 V on a standard 4 × 65-μm T-gated FET and then 12.5 W/mm at 10 GHz and VDS = 60 V on a 4 × 75-μm T-gated FET by adding a field plate. These are the highest reported power densities achieved simultaneously at X-band and Ka-band in a single wideband GaN MMIC process.
Spread of the pandemic Zika virus lineage is associated with NS1 codon usage adaptation in humans

Zika virus (ZIKV) infections were more common in the zoonotic cycle until the end of the 20th century with few human cases in Africa and Southeastern Asia. Recently, the Asian lineage of ZIKV is spreading along human-to-human chains of transmission in the Pacific Islands and in South America. To better understand its recent urban expansion, we compared genetic differences among the lineages. Herein we show that the recent Asian lineage spread is associated with significant NS1 codon usage adaptation to human housekeeping genes, which could facilitate viral replication and increase viral titers. These findings were supported by a significant correlation with growth in Malthusian fitness. Furthermore, we predicted several epitopes in the NS1 protein that are shared between ZIKV and Dengue. Our results imply in a significant dependence of the recent human ZIKV spread on NS1 translational selection.
The GATA2 transcription factor negatively regulates the proliferation of neuronal progenitors

Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion that requires proper spatial and temporal coordination of proliferation, fate determination, differentiation and morphogenesis. This probably relies on complex interplay between mechanisms that control cell cycle, specification and differentiation. In this respect, we have studied the possible implication of GATA2, a transcription factor that is involved in several neuronal specification pathways, in the control of the proliferation of neural progenitors in the embryonic spinal cord. Using gain- and loss-of-function manipulations, we have shown that Gata2 can drive neural progenitors out of the cycle and, to some extent, into differentiation. This correlates with the control of cyclin D1 transcription and of the expression of the p27/Kip1 protein. Interestingly, this functional aspect is not only associated with silencing of the Notch pathway but also appears to be independent of proneural function. Consistently, GATA2 also controls the proliferation capacity of mouse embryonic neuroepithelial cells in culture. Indeed, Gata2 inactivation enhances the proliferation rate in these cells. By contrast, GATA2 overexpression is sufficient to force such cells and neuroblastoma cells to stop dividing but not to drive either type of cell into differentiation. Furthermore, a non-cell autonomous effect of Gata2 expression was observed in vivo as well as in vitro. Hence, our data have provided evidence for the ability of Gata2 to inhibit the proliferation of neural progenitors, and they further suggest that, in this regard, Gata2 can operate independently of neuronal differentiation.
On the Genesis of Postmidnight Equatorial Spread F: Results for the American/Peruvian Sector

Previous studies of the Earth's low‐latitude ionosphere using in situ measurements made by sensors on the Communication/Navigation Outage Forecasting System (C/NOFS) satellite showed an unexpected predominance of equatorial spread F (ESF) events in the postmidnight sector during June and December solstice months of the 2008–2009 deep solar minimum. It has been suggested that these events might have been driven by the unusual behavior of the equatorial plasma drifts, which showed an abnormal upward peak around midnight during the same period. We use coherent backscatter radar (Jicamarca Unattended Long‐term Investigations of the Ionosphere and Atmosphere ‐ JULIA) measurements made at the Jicamarca Radio Observatory (11.95°S, 76.87°W, ∼1∘ dip lat) in Peru to better understand the origin of the ESF irregularities observed by C/NOFS. The radar observations show that ESF events during December solstice start in the postsunset sector. These ESF events and the conditions for their development are shown to continue through midnight hours. The predominance of postmidnight irregularities on C/NOFS observations during December solstice is caused by the slow vertical development of the ESF structures, which only reach the topside near midnight in most cases. On June solstice, however, JULIA observations show that ESF started predominately in the midnight to postmidnight sector. Collocated digisonde observations provide additional insight on F‐region conditions leading to these ESF events.