Miracle-dz/UniFAR-FTUs huggingface dataset:
Activity adherence and physical function in older adults with functional limitations.

PURPOSE Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) was a trial to examine the effects of a physical activity intervention (PA) compared with a health education control (SA) on measures of disability risk in sedentary older adults (N = 424). We examined adherence to the LIFE-P PA intervention for the first 12 months of the trial. METHODS The PA intervention consisted of walking, strength, flexibility, and balance training supplemented with behavioral skills training modules, and it used a phased, center-based schedule of adoption (3x wk(-1), weeks 1-8), transition (2x wk(-1), weeks 9-24), and maintenance (1x wk(-1), weeks 25 to end of trial) while transitioning to primarily home-based physical activity. SA consisted of weekly (weeks 1-26) transitioning to monthly health education workshops. RESULTS Participation in moderate-intensity physical activity increased from baseline to months 6 and 12 in PA compared with SA (P < 0.001). At 12 months, PA participants who reported > or = 150 min x wk(-1) of moderate activity demonstrated a significantly greater improvement in their Short Physical Performance Battery score compared with participants who reported < 150 min.wk of moderate activity (P < 0.017). For the PA arm, center-based attendance was 76.3 +/- 24.5, 65.4 +/- 28.6, and 49.8 +/- 35.8% in the adoption, transition, and maintenance phases, respectively. CONCLUSIONS Adherence to physical activity in LIFE-P was associated with greater improvement in SPPB score and was consistent with adherence in physical activity trials of shorter duration in this subgroup of older adults. Older individuals at risk for disability can adhere to a regular program of physical activity in a long-term randomized trial.
A Highly Efficient VLSI Architecture for H.264/AVC Level 5.1 CABAC Decoder

In this paper, a high throughput context-based adaptive binary arithmetic coding decoder design is proposed. This decoder employs a syntax element prediction method to solve pipeline hazard problems. It also uses a new hybrid memory two-symbol parallel decoding in order to enhance performance as well as to reduce costs. The critical path delay of the two-symbol binary arithmetic decoding engine is improved by 28% with an efficient mathematical transform. Experimental results show that the throughput of our proposed design can reach 485.76 Mbins/s in the high bit-rate coding and 446.2 Mbins/s on average at 264MHz operating frequency, which is sufficient to support H.264/AVC level 5.1 real-time decoding.
Quantum Entropy Function from AdS(2)/CFT(1) Correspondence

We review and extend recent attempts to find a precise relation between extremal black hole entropy and degeneracy of microstates using AdS2/CFT1 correspondence. Our analysis leads to a specific relation between degeneracy of black hole microstates and an appropriately defined partition function of string theory on the near horizon geometry — named the quantum entropy function. In the classical limit this reduces to the usual relation between statistical entropy and Wald entropy.
Effects of internal medicine residency training in AIDS care in Taiwan

Having contact and interacting with HIV/AIDS patients has long been recognized as a means for improving AIDS-related knowledge and attitudes among physicians and hence for increasing their intention to provide AIDS care. To investigate the impact of one-month residency training in an AIDS inpatient unit on internal medicine residents, this quasi-experimental, pre-post, two-group study, conducted from April 2000 to April 2001, used questionnaires. At follow-up, residents who received training in the AIDS unit (experimental group) were significantly more knowledgeable about HIV/AIDS, had more positive attitudes and greater intention to care for HIV-infected patients than residents who did not receive this training (control group). Results suggest that a one-month AIDS residency training intervention can effectively enhance residents' HIV-related knowledge, attitudes and intention to care for patients infected with HIV.
DONSKER-TYPE THEOREM FOR BSDES

This paper is devoted to the proof of Donsker's theorem for backward stochastic differential equations (BSDEs for short). The main objective is to give a simple method to discretize in time a BSDE. Our approach is based upon the notion of ``convergence of filtrations'' and covers the case of a $(y,z)$-dependent generator.
Does mental activity change the oxidative metabolism of the brain?

Previous studies have shown that sensory stimulation and voluntary motor activity increase regional cerebral glucose consumption and regional cerebral blood flow (rCBF). The present study had 3 purposes: (1) to examine whether pure mental activity changed the oxidative metabolism of the brain and, if so, (2) to examine which anatomical structures were participating in the mental activity; and to examine whether there was any coupling of the rCBF to the physiological changes in the regional cerebral oxidative metabolism (rCMRO2). With a positron- emission tomograph (PET), we measured the rCMRO2, rCBF, and regional cerebral blood volume (rCBV) in independent sessions lasting 100 sec each. A dynamic method was used for the measurement of rCMRO2. The rCMRO2, rCBF, and rCBV were measured in 2 different states in 10 young, healthy volunteers: at rest and when visually imagining a specific route in familiar surroundings. The rCBF at rest was linearly correlated to the rCMRO2: rCBF (in ml/100 gm/min) = 11.4 rCMRO2 + 11.9. The specific mental visual imagery increased the rCMRO2 in 25 cortical fields, ranging in size from 2 to 10 cm3, located in homotypical cortex. Active fields were located in the superior and lateral prefrontal cortex and the frontal eye fields. The strongest increase of rCMRO2 appeared in the posterior superior lateral parietal cortex and the posterior superior medial parietal cortex in precuneus. Subcortically, the rCMRO2 increased in neostriatum and posterior thalamus. These focal metabolic increases were so strong that the CMRO2 of the whole brain increased by 10%. The rCBF increased proportionally in these active fields and structures, such that d(rCBF) in ml/100 gm/min = 11.1 d(rCMRO2). Thus, a dynamic coupling of the rCBF to the rCMRO2 was observed during the physiological increase in neural metabolism. On the basis of previous functional activation studies and our knowledge of anatomical connections in man and other primates, the posterior medial and lateral parietal cortices were classified as remote visual-association areas participating in the generation of visual images of spatial scenes from memory, and the posterior thalamus was assumed to participate in the retrieval of such memories.
Validation of the measure of processes of care for use when there is no Child Development Centre.

INTRODUCTION Clinical governance requires measurement of the outcomes of health care. The Measure of Processes of Care (MPOC; King, Rosenbaum & King 1995) is a postal questionnaire developed in Canada to reflect parents' perceptions of the quality of services received. AIM To examine the usefulness of the MPOC for the evaluation of services for children with disabilities and their families. METHODS The MPOC was revised minimally for British idiom, taking out explicit references to a 'Centre'. Surveys of parents using child disability services were carried out in three rural and two urban communities, where there are no Child Development Centres, with a total of 495 analysable questionnaires returned. In addition, 32 parents using a home nursing service for children with multiple disabilities completed questionnaires. RESULTS The rate of return ranged from 49% to 67%. Factor analysis confirmed a five-factor solution but only one factor mapped clearly onto the Canadian structure. Using the revised structure, the surveys provide evidence of the discriminating potential of the MPOC, comparing the perceptions of parents who do or do not have a care coordinator, and comparing recipients of a home nursing service with matched users of general services. CONCLUSIONS The MPOC can be used as a measure of outcome for child disability services of differing organizational structures.
Critical Assessment 11: Structural repairs by cold spray

Abstract The deposition of material by cold spray is a relatively new technology. It is often applied to coating applications but can be used for the repair of defects in and damage to metal structures. The use of cold spray for repair is often favoured because, unlike thermal spray methods, cold spray does not bring about heat related damage to the component under repair. The status of the technology and the barriers to widespread commercial application are assessed. The types of repair that have been made with cold spray are discussed, and the unique features of cold spray that permit successful repairs are demonstrated.
Structure of a partially unfolded form of Escherichia coli dihydrofolate reductase provides insight into its folding pathway

Proteins frequently fold via folding intermediates that correspond to local minima on the conformational energy landscape. Probing the structure of the partially unfolded forms in equilibrium under native conditions can provide insight into the properties of folding intermediates. To elucidate the structures of folding intermediates of Escherichia coli dihydrofolate reductase (DHFR), we investigated transient partial unfolding of DHFR under native conditions. We probed the structure of a high‐energy conformation susceptible to proteolysis (cleavable form) using native‐state proteolysis. The free energy for unfolding to the cleavable form is clearly less than that for global unfolding. The dependence of the free energy on urea concentration (m‐value) also confirmed that the cleavable form is a partially unfolded form. By assessing the effect of mutations on the stability of the partially unfolded form, we found that native contacts in a hydrophobic cluster formed by the F‐G and Met‐20 loops on one face of the central β‐sheet are mostly lost in the partially unfolded form. Also, the folded region of the partially unfolded form is likely to have some degree of structural heterogeneity. The structure of the partially unfolded form is fully consistent with spectroscopic properties of the near‐native kinetic intermediate observed in previous folding studies of DHFR. The findings suggest that the last step of the folding of DHFR involves organization in the structure of two large loops, the F‐G and Met‐20 loops, which is coupled with compaction of the rest of the protein.
Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory

We review lesion and neuroimaging evidence on the role of the hippocampus, and other structures, in retention and retrieval of recent and remote memories. We examine episodic, semantic and spatial memory, and show that important distinctions exist among different types of these memories and the structures that mediate them. We argue that retention and retrieval of detailed, vivid autobiographical memories depend on the hippocampal system no matter how long ago they were acquired. Semantic memories, on the other hand, benefit from hippocampal contribution for some time before they can be retrieved independently of the hippocampus. Even semantic memories, however, can have episodic elements associated with them that continue to depend on the hippocampus. Likewise, we distinguish between experientially detailed spatial memories (akin to episodic memory) and more schematic memories (akin to semantic memory) that are sufficient for navigation but not for re‐experiencing the environment in which they were acquired. Like their episodic and semantic counterparts, the former type of spatial memory is dependent on the hippocampus no matter how long ago it was acquired, whereas the latter can survive independently of the hippocampus and is represented in extra‐hippocampal structures. In short, the evidence reviewed suggests strongly that the function of the hippocampus (and possibly that of related limbic structures) is to help encode, retain, and retrieve experiences, no matter how long ago the events comprising the experience occurred, and no matter whether the memories are episodic or spatial. We conclude that the evidence favours a multiple trace theory (MTT) of memory over two other models: (1) traditional consolidation models which posit that the hippocampus is a time‐limited memory structure for all forms of memory; and (2) versions of cognitive map theory which posit that the hippocampus is needed for representing all forms of allocentric space in memory.
Effect of repetitive hypoxic apnoeas on baroreflex function in humans

Baroreflex function is impaired in patients with obstructive sleep apnoea. We tested the hypothesis that short‐term exposure to repetitive hypoxic apnoeas (RHA) produces prolonged impairment in baroreflex function. Baroreflex function was determined using the modified Oxford technique in 14 subjects (26 ± 1 years). Baroreflex sensitivity (BRS) was quantified from the R‐R interval–systolic blood pressure (BP; cardiovagal BRS), heart rate–systolic BP (HR BRS) and muscle sympathetic nerve activity (MSNA)–diastolic BP (sympathetic BRS) relations. RHA involved subjects performing repetitive end‐expiratory apnoeas (20 s) every minute for 30 min during intermittent hypoxia to accentuate oxygen desaturation. After RHA, BP and MSNA at rest were elevated. BRS was measured ∼7 (Post 1), ∼30 (Post 2) and ∼50 min (Post 3) after RHA to provide insight into the temporal pattern of responses. Cardiovagal BRS (16.8 ± 1.3, 16.5 ± 1.6, 17.6 ± 2.0 and 17.4 ± 1.5 ms mmHg−1 for Pre, Post 1, Post 2 and Post 3, respectively), HR BRS (−1.1 ± 0.1, −1.1 ± 0.1, −1.3 ± 0.1 and −1.4 ± 0.1 beats min−1 mmHg−1) and sympathetic BRS (−4.5 ± 0.6, −4.4 ± 0.7, −3.7 ± 0.5 and −4.7 ± 1.0 arbitrary units (au) beat−1 mmHg−1) were unchanged by RHA. In contrast, the operating points of the baroreflexes were shifted rightward (to higher levels of BP) and upward (to higher levels of heart rate and MSNA) after RHA (P < 0.05). Time control studies performed in five additional subjects showed no change in any of the measured variables over time. Collectively, these data indicate that short‐term exposure to RHA shifts (‘resets’) the baroreflex stimulus–response curve to higher levels of BP without influencing BRS for extended periods of time.
Glucose-stimulated genes and prospects of gene therapy for type I diabetes.

I. Introduction II. Transcriptional Regulation of Glucose-Responsive Genes A. The insulin gene 1. Glucose-signaling pathway in pancreas β-cells 2. E elements of the insulin gene promoter 3. A elements of the insulin gene promoter 4. Role of the E and A boxes of the insulin gene promoters in glucose-dependent transcriptional regulation 5. Role of the cAMP pathway in glucose responsiveness of the insulin gene promoters B. Transcriptional regulation of glucose-responsive genes in the liver 1. The general outlook for glucose metabolism in the liver 2. Transcriptional glucose signaling mechanisms in the liver 3. Glucose/carbohydrate response elements III. Cell and Gene Therapies for IDDM A. Islet and cell transplantations 1. Transplantation of islets 2. Transplantation of established lines B. Bioartificial pancreas C. Transplantation of genetically engineered cells 1. The “ideal” engineered cell for glucose-dependent insulin secretion 2. Engineering established neuroendocrine cells 3. Engineering endogenous he.
Rare association of cutaneous vasculitis, IgA nephropathy and antiphospholipid antibody syndrome with tuberculous lymphadenitis

Roberto Bueno Filho, Alberto Pinto Cordeiro, Flavia Tremeschin de Almeida, Catarina Shaletich, Roberto Silva Costa, Ana Maria F. Roselino I University of São Paulo, School of Medicine of Ribeirão Preto, Department of Medical Clinics, Division of Dermatology, Ribeirão Preto/SP, Brazil. II University of São Paulo, School of Medicine of Ribeirão Preto, Department of Medical Clinics, Division of Dermatology, Biomedical, Laboratory of Molecular Biology, Ribeirão Preto/SP, Brazil. III University of São Paulo, School of Medicine of Ribeirão Preto, Hospital of Clinics, Department of Pathology, Ribeirão Preto/SP, Brazil.
Engineering a Deep HPSG for Mandarin Chinese

In this paper, we present our on-going grammar development effort towards a linguistically precise and broad coverage grammar for Mandarin Chinese in the framework of HPSG. The use of LinGO Grammar Matrix facilitates the quick start of the development. We propose a series of linguistic treatments for a list of interesting phenomena. The analyses are largely compatible with the HPSG framework. In addition, the grammar also composes semantic representations in Minimum Recursion Semantics. Preliminary tests of the grammar on a phenomenon-oriented test suite show encouraging precision and coverage.
Effect of the deposition temperature on the properties of iridium thin films grown by means of pulsed laser deposition

Pulsed laser deposition (PLD) of Ir thin films has been achieved by ablating an iridium target with a KrF excimer laser. The iridium deposition rate was investigated, over the (0.4–2) × 10^9 W/cm^2 laser intensity range, and found to reach its maximum at (1.6 ± 0.1) × 10^9 W/cm^2. At this laser intensity, the PLD Ir films were deposited at substrate deposition temperatures ranging from 20 to 600 °C. The PLD Ir films exhibited a (111) preferentially oriented polycrystalline structure with their average grain size increasing from about 10 to 30 nm as the deposition temperature was raised from 20 to 600 °C. Their mean surface microroughness ( R _a) was found to change from an average value of about 1 nm in the 20–400 °C temperature range to a value of about 4.5 nm at 600 °C. As the deposition temperature is varied from 20 to 600 °C, not only does the stress of PLD Ir films change drastically from highly compressive (−2.5 GPa) to tensile (+0.8 GPa), but their room-temperature resistivity also gradually decreases in the 20–400 °C range and stabilizes for higher temperatures. In the 400–600 °C range, the resistivity of PLD Ir films was as low as 6.0 ± 0.2 μΩ cm, which is very close to the iridium bulk value of 5.1 μΩ cm. Thus, PLD Ir films exhibiting not only the lowest resistivity but also a nearly zero stress level can be grown at a deposition temperature of about 400 °C. The resistivity of the PLD Ir films can be described by a grain boundary scattering model.
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics

Protein expression of major hepatobiliary drug transporters (NTCP, OATPs, OCT1, BSEP, BCRP, MATE1, MRPs, and P-gp) in cancerous (C, n = 8) and adjacent noncancerous (NC, n = 33) liver tissues obtained from patients with chronic hepatitis C with hepatocellular carcinoma (HCV-HCC) were quantified by LC-MS/MS proteomics. Herein, we compare our results with our previous data from noninfected, noncirrhotic (control, n = 36) and HCV-cirrhotic (n = 30) livers. The amount of membrane protein yielded from NC and C HCV-HCC tissues decreased (31%, 67%) relative to control livers. In comparison with control livers, with the exception of NTCP, MRP2, and MATE1, transporter expression decreased in NC (38%–76%) and C (56%–96%) HCV-HCC tissues. In NC HCV-HCC tissues, NTCP expression increased (113%), MATE1 expression decreased (58%), and MRP2 expression was unchanged relative to control livers. In C HCV-HCC tissues, NTCP and MRP2 expression decreased (63%, 56%) and MATE1 expression was unchanged relative to control livers. Compared with HCV-cirrhotic livers, aside from NTCP, OCT1, BSEP, and MRP2, transporter expression decreased in NC (41%–71%) and C (54%–89%) HCV-HCC tissues. In NC HCV-HCC tissues, NTCP and MRP2 expression increased (362%, 142%), whereas OCT1 and BSEP expression was unchanged. In C HCV-HCC tissues, OCT1 and BSEP expression decreased (90%, 80%) relative to HCV-cirrhotic livers, whereas NTCP and MRP2 expression was unchanged. Expression of OATP2B1, BSEP, MRP2, and MRP3 decreased (56%–72%) in C HCV-HCC tissues in comparison with matched NC tissues (n = 8), but the expression of other transporters was unchanged. These data will be helpful in the future to predict transporter-mediated hepatocellular drug concentrations in patients with HCV-HCC.
Defect in general priming conferred by linker region mutants of Escherichia coli dnaB

The dnaB gene of Escherichia coli encodes a bifunctional primase accessory protein/helicase necessary for chromosomal replication. Monomers of DnaB comprise two trypsin-resistant domains connected by a 45-amino-acid linker. To investigate the role of the linker in the structure and function of DnaB, we have purified and characterized three DnaB mutant proteins having single amino acid substitutions in the linker. We find that the mutant proteins retain the two-domain structure and assemble into hexamers that may be less stable than hexamers formed by wild-type DnaB. These mutant hexamers have hydrodynamic properties slightly different from those of the wild type, suggestive of a more open structure. The mutant proteins had reduced or absent ability to stimulate primase and also exhibited slight alterations in ATPase activity compared with the wild type. We conclude that the linker region promotes primase-DnaB interaction, but this effect may be indirect. We propose a model involving repositioning of N-terminal domains to explain the properties of the mutant proteins.
Evidence of constant diversification punctuated by a mass extinction in the African cycads

The recent evidence that extant cycads are not living fossils triggered a renewed search for a better understanding of their evolutionary history. In this study, we investigated the evolutionary diversification history of the genus Encephalartos, a monophyletic cycad endemic to Africa. We found an antisigmoidal pattern with a plateau and punctual explosive radiation. This pattern is typical of a constant radiation with mass extinction. The rate shift that we found may therefore be a result of a rapid recolonization of niches that have been emptied owing to mass extinction. Because the explosive radiation occurred during the transition Pliocene–Pleistocene, we argued that the processes might have been climatically mediated.
Correlation Between Solidification Behavior and Melt Crystallization Kinetics of Isotactic Polypropylene (iPP) during Injection Molding

The relationship between solidification behavior and crystallization kinetics, during the injection molding process of isotactic polypropylene (iPP) was investigated. It was found that the crystallization rate was in proportion to the cooling rate. The existence of a turning point (TP) in the dimensionless temperature (θ) vs. ln t curve, which is potentially applicable for the estimation of cooling time, was experimentally verified for iPP. The present study is expected to be useful for the optimization of the processing conditions during injection molding of crystalline polymers, and also supplies a good insight into further study of the “processing-structure-property” relationship of polymeric materials.