Miracle-dz/UniFAR-FTUs huggingface dataset:
Visual stimuli recruit intrinsically generated cortical ensembles

Significance This study demonstrates that neuronal groups or ensembles, rather than individual neurons, are emergent functional units of cortical activity. We show that in the presence and absence of visual stimulation, cortical activity is dominated by coactive groups of neurons forming ensembles. These ensembles are flexible and cannot be accounted for by the independent firing properties of neurons in isolation. Intrinsically generated ensembles and stimulus-evoked ensembles are similar, with one main difference: Whereas intrinsic ensembles recur at random time intervals, visually evoked ensembles are time-locked to stimuli. We propose that visual stimuli recruit endogenously generated ensembles to represent visual attributes. The cortical microcircuit is built with recurrent excitatory connections, and it has long been suggested that the purpose of this design is to enable intrinsically driven reverberating activity. To understand the dynamics of neocortical intrinsic activity better, we performed two-photon calcium imaging of populations of neurons from the primary visual cortex of awake mice during visual stimulation and spontaneous activity. In both conditions, cortical activity is dominated by coactive groups of neurons, forming ensembles whose activation cannot be explained by the independent firing properties of their contributing neurons, considered in isolation. Moreover, individual neurons flexibly join multiple ensembles, vastly expanding the encoding potential of the circuit. Intriguingly, the same coactive ensembles can repeat spontaneously and in response to visual stimuli, indicating that stimulus-evoked responses arise from activating these intrinsic building blocks. Although the spatial properties of stimulus-driven and spontaneous ensembles are similar, spontaneous ensembles are active at random intervals, whereas visually evoked ensembles are time-locked to stimuli. We conclude that neuronal ensembles, built by the coactivation of flexible groups of neurons, are emergent functional units of cortical activity and propose that visual stimuli recruit intrinsically generated ensembles to represent visual attributes.
Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis

OPA1 mutations cause protein haploinsufficiency leading to dominant optic atrophy (DOA), an incurable retinopathy with variable severity. Up to 20% of patients also develop extraocular neurological complications. The mechanisms that cause this optic atrophy or its syndromic forms are still unknown. After identifying oxidative stress in a mouse model of the pathology, we sought to determine the consequences of OPA1 dysfunction on redox homeostasis.
Corrective Feedback on Pronunciation: Students’ and Teachers’ Perceptions

The aim of this research was to find out similarities and differences between teacher and student perceptions of corrective feedback (CF) on pronunciation for students’ presentations in advanced English class through a group interview and a questionnaire survey. Both teachers and students agreed that CF is not only important but necessary since junior and senior students still have pronunciation problems and the best time to provide CF is soon after presentation. However, they differed in concern about students’ self-respect, the types of errors that should receive CF and preference for the types of CF. In particular, students’ eagerness to learn exceeded their concern about self-respect. Teachers turned to offer CF to repeated errors, while students would like to receive more than teachers could offer. Moreover, teachers regarded prompt as being more effective, whereas students preferred recast to prompt considering the latter to be more demanding though they held similar views about explicit correction. It is suggested that taking into consideration both teachers’ and students’ perceptions of CF would help improve senior and junior students’ pronunciation.
Characteristics and Outcomes of Cocaine-Related Spontaneous Intracerebral Hemorrhages

To date there is only one single-center study that has exclusively reported characteristics, location, and outcomes of spontaneous intracerebral hemorrhages (ICH) among cocaine users. We aimed to describe the radiological location and characteristics along with clinical outcomes of spontaneous ICH in a similar population. We conducted a retrospective chart review of consecutive patients admitted to a tertiary care hospital, with a spontaneous ICH, who had a urine drug screen performed within 48 hours of admission. Exposure to cocaine was defined by a positive urine drug screen within 48 hours of hospital admission. Demographics, radiographic features of ICH, and short-term clinical outcomes of patients with a positive urine drug screen were analyzed and compared with the cocaine negative group. Among the 102 patients analyzed, 20 (19.6%) had documented exposure to cocaine. There was a predominance of males in both groups with significantly more Blacks in the cocaine positive group (P = 0.0246). A statistically significant number of patients with cocaine use had ICH in a subcortical location (P = 0.0224) when compared to cocaine negative patients. There was no difference in GCS, ICH volume, intraventricular extension, ICU days, hospital days, hospital cost, mortality, and ICH score. ICH in cocaine use is more frequently seen in the subcortical location.
The PowerNap Server Architecture

Data center power consumption is growing to unprecedented levels: the EPA estimates U.S. data centers will consume 100 billion kilowatt hours annually by 2011. Much of this energy is wasted in idle systems: in typical deployments, server utilization is below 30%, but idle servers still consume 60% of their peak power draw. Typical idle periods---though frequent---last seconds or less, confounding simple energy-conservation approaches. In this article, we propose PowerNap, an energy-conservation approach where the entire system transitions rapidly between a high-performance active state and a near-zero-power idle state in response to instantaneous load. Rather than requiring fine-grained power-performance states and complex load-proportional operation from individual system components, PowerNap instead calls for minimizing idle power and transition time, which are simpler optimization goals. Based on the PowerNap concept, we develop requirements and outline mechanisms to eliminate idle power waste in enterprise blade servers. Because PowerNap operates in low-efficiency regions of current blade center power supplies, we introduce the Redundant Array for Inexpensive Load Sharing (RAILS), a power provisioning approach that provides high conversion efficiency across the entire range of PowerNap’s power demands. Using utilization traces collected from enterprise-scale commercial deployments, we demonstrate that, together, PowerNap and RAILS reduce average server power consumption by 74%.
Mothers and Fathers, Churches and Schools: Formal and Informal Sources of Sexual Information as they Relate to Emerging Adult Women's Safe Sex Practices and Sexual-esteem

iii LIST OF TABLES.v INTRODUCTION.1 LITERATURE REVIEW.3 METHOD.16 RESULTS.20 DISCUSSION.27 REFERENCES.38 APPENDIX A: SEXUAL-ESTEEM SUBSCALE.46
Effect of multidimensional lifestyle intervention on fitness and adiposity in predominantly migrant preschool children (Ballabeina): cluster randomised controlled trial

Objective To test the effect of a multidimensional lifestyle intervention on aerobic fitness and adiposity in predominantly migrant preschool children. Design Cluster randomised controlled single blinded trial (Ballabeina study) over one school year; randomisation was performed after stratification for linguistic region. Setting 40 preschool classes in areas with a high migrant population in the German and French speaking regions of Switzerland. Participants 652 of the 727 preschool children had informed consent and were present for baseline measures (mean age 5.1 years (SD 0.7), 72% migrants of multicultural origins). No children withdrew, but 26 moved away. Intervention The multidimensional culturally tailored lifestyle intervention included a physical activity programme, lessons on nutrition, media use (use of television and computers), and sleep and adaptation of the built environment of the preschool class. It lasted from August 2008 to June 2009. Main outcome measures Primary outcomes were aerobic fitness (20 m shuttle run test) and body mass index (BMI). Secondary outcomes included motor agility, balance, percentage body fat, waist circumference, physical activity, eating habits, media use, sleep, psychological health, and cognitive abilities. Results Compared with controls, children in the intervention group had an increase in aerobic fitness at the end of the intervention (adjusted mean difference: 0.32 stages (95% confidence interval 0.07 to 0.57; P=0.01) but no difference in BMI (−0.07 kg/m2, −0.19 to 0.06; P=0.31). Relative to controls, children in the intervention group had beneficial effects in motor agility (−0.54 s, −0.90 to −0.17; P=0.004), percentage body fat (−1.1%, −2.0 to −0.2; P=0.02), and waist circumference (−1.0 cm, −1.6 to −0.4; P=0.001). There were also significant benefits in the intervention group in reported physical activity, media use, and eating habits, but not in the remaining secondary outcomes. Conclusions A multidimensional intervention increased aerobic fitness and reduced body fat but not BMI in predominantly migrant preschool children. Trial registration Clinical Trials NCT00674544.
Starbirth in Galaxy Collisions

Young, massive star clusters are the most notable and signican t end products of violent star-forming episodes triggered by galaxy collisions, mergers, and close encounters. Their contribution to the total luminosity induced by such extreme conditions dominates, by far, the overall energy output due to the gravitationally-induced star formation. The general characteristics of these newly-formed clusters (such as their masses, luminosities, and sizes) suggest that at least a fraction may eventually evolve into equal, or perhaps slightly more massive, counterparts of the abundant old globular cluster systems in the local Universe. Establishing whether or not such an evolutionary connection exists requires our detailed knowledge of not only the physics underlying the evolution of \simple" stellar populations, but also that of cluster disruption in the time-dependent gravitational potentials of interacting galaxies. Initial results seem to indicate that proto-globular clusters do indeed continue to form today, which would support hierarchical galaxy formation scenarios.
The inverted-lecture model: a case study in computer architecture

This paper reports on an experience in using the inverted-lecture model ("flipping the classroom") in computer architecture. The first author concurrently taught two courses in computer architecture. One of these courses was CSC/ECE 506: Architecture of Parallel Computers, an introductory Graduate-level course, taught via lecture both residentially and distance-ed. The other was the CSC 456: Computer Architecture and Multiprocessing, a senior-level undergraduate course which was "flipped. " Students in the inverted-lecture class exhibited high levels of engagement. Their performance on exams was not quite up to the level of the students in the graduate class, but the difference was not wide. From this experience, we offer observations and suggestions about inverted classes in general.
A Multiagent Approach to $Q$-Learning for Daily Stock Trading

The portfolio management for trading in the stock market poses a challenging stochastic control problem of significant commercial interests to finance industry. To date, many researchers have proposed various methods to build an intelligent portfolio management system that can recommend financial decisions for daily stock trading. Many promising results have been reported from the supervised learning community on the possibility of building a profitable trading system. More recently, several studies have shown that even the problem of integrating stock price prediction results with trading strategies can be successfully addressed by applying reinforcement learning algorithms. Motivated by this, we present a new stock trading framework that attempts to further enhance the performance of reinforcement learning-based systems. The proposed approach incorporates multiple Q-learning agents, allowing them to effectively divide and conquer the stock trading problem by defining necessary roles for cooperatively carrying out stock pricing and selection decisions. Furthermore, in an attempt to address the complexity issue when considering a large amount of data to obtain long-term dependence among the stock prices, we present a representation scheme that can succinctly summarize the history of price changes. Experimental results on a Korean stock market show that the proposed trading framework outperforms those trained by other alternative approaches both in terms of profit and risk management.
Who’s at risk? Expanding the categorical understanding of children at risk of social exclusion through measures of self-esteem

Abstract A strong focus on early intervention involves broad categories by which to assess children at risk of social marginalisation. Most of these categories relate to family characteristics and qualities. In this article, we explore social vulnerability from children’s perspectives and consider whether their self-esteem provides evidence for risk of social marginalisation, here understood as exclusion from social, academic, and cultural communities. The data are derived from a survey of 10-year-old children in the south of Norway on their everyday life and well-being (N = 1360). We have constructed an index of global self-esteem. First, we find a significant correlation between low global self-esteem and personal social vulnerability. Next, we quite surprisingly find no significant correlation between children’s global self-esteem and their family characteristics. The final analysis reveals a correlation between children’s global self-esteem and their social networks. These results prompt us to question some of the common assumptions about the association between family characteristics and social vulnerability. Our results show that more attention should be paid to children’s social networks, regardless of family characteristics. More importantly, the results show that global self-esteem – including self-evaluations of academic skills, athletic skills, feelings of self-worth, and sociability – is a fruitful approach to expanding our categorical understanding of children at risk.
A Biophysically Based Neural Model of Matching Law Behavior: Melioration by Stochastic Synapses

In experiments designed to uncover the neural basis of adaptive decision making in a foraging environment, neuroscientists have reported single-cell activities in the lateral intraparietal cortex (LIP) that are correlated with choice options and their subjective values. To investigate the underlying synaptic mechanism, we considered a spiking neuron model of decision making endowed with synaptic plasticity that follows a reward-dependent stochastic Hebbian learning rule. This general model is tested in a matching task in which rewards on two targets are scheduled randomly with different rates. Our main results are threefold. First, we show that plastic synapses provide a natural way to integrate past rewards and estimate the local (in time) “return” of a choice. Second, our model reproduces the matching behavior (i.e., the proportional allocation of choices matches the relative reinforcement obtained on those choices, which is achieved through melioration in individual trials). Our model also explains the observed “undermatching” phenomenon and points to biophysical constraints (such as finite learning rate and stochastic neuronal firing) that set the limits to matching behavior. Third, although our decision model is an attractor network exhibiting winner-take-all competition, it captures graded neural spiking activities observed in LIP, when the latter were sorted according to the choices and the difference in the returns for the two targets. These results suggest that neurons in LIP are involved in selecting the oculomotor responses, whereas rewards are integrated and stored elsewhere, possibly by plastic synapses and in the form of the return rather than income of choice options.
The innateness of binding and coreference

Grimshaw and Rosen have recently argued that the standard binding theory, as formulated in the Governement-Binding(GR) framework is innate. Results indicating that children do not know the coreference aspects of the standard binding theory are due to performance factors that mask this knowledge, leading, in GR's opinion, to the poor scores on tasks that supposedly test it. We will argue that the acquisition finding GR discuss do not lead to the conclusions they reach
A digital to time converter with fully digital calibration scheme for ultra-low power ADPLL in 40 nm CMOS

In this paper, a digital-to-time converter (DTC) assisting a time-to-digital converter (TDC) as a fractional phase error detector in an ultra-low power ADPLL is proposed and demonstrated in 40nm CMOS. A phase prediction algorithm via the assistance of the DTC reduces the required TDC range, thus saving substantial power. Additionally, a fully digital calibration algorithm is presented and proved to validate the whole ADPLL system and improve the DTC linearity. At 1 V supply voltage, the measured time resolution of the DTC is 22 ps. The TDC resolution is also indirectly measured with a closed-loop 2.4 GHz ADPLL, where -95.3 dBc/Hz in-band phase noise corresponds to a worst-case TDC resolution of 22 ps.
Functional analysis and regulation of purified connexin hemichannels

Gap-junction channels (GJCs) are aqueous channels that communicate adjacent cells. They are formed by head-to-head association of two hemichannels (HCs), one from each of the adjacent cells. Functional HCs are connexin hexamers composed of one or more connexin isoforms. Deafness is the most frequent sensineural disorder, and mutations of Cx26 are the most common cause of genetic deafness. Cx43 is the most ubiquitous connexin, expressed in many organs, tissues, and cell types, including heart, brain, and kidney. Alterations in its expression and function play important roles in the pathophysiology of very frequent medical problems such as those related to cardiac and brain ischemia. There is extensive information on the relationship between phosphorylation and Cx43 targeting, location, and function from experiments in cells and organs in normal and pathological conditions. However, the molecular mechanisms of Cx43 regulation by phosphorylation are hard to tackle in complex systems. Here, we present the use of purified HCs as a model for functional and structural studies. Cx26 and Cx43 are the only isoforms that have been purified, reconstituted, and subjected to functional and structural analysis. Purified Cx26 and Cx43 HCs have properties compatible with those demonstrated in cells, and present methodologies for the functional analysis of purified HCs reconstituted in liposomes. We show that phosphorylation of serine 368 by PKC produces a partial closure of the Cx43 HCs, changing solute selectivity. We also present evidence that the effect of phosphorylation is highly cooperative, requiring modification of several connexin subunits, and that phosphorylation of serine 368 elicits conformational changes in the purified HCs. The use of purified HCs is starting to provide critical data to understand the regulation of HCs at the molecular level.
Haplotypes in the Complement Factor H (CFH) Gene: Associations with Drusen and Advanced Age-Related Macular Degeneration

Background Age-related macular degeneration (AMD), the leading cause of blindness in the Western world, is a complex disease that affects people over 50 years old. The complement factor H (CFH) gene has been repeatedly shown to be a major factor in determining susceptibility to the advanced form of the condition. We aimed to better understand the functional role of this gene in the AMD disease process and assess whether it is associated with earlier forms of the disease. Methodology/Principal Findings We genotyped SNPs at the CFH gene locus in three independent populations with AMD: (a) extended families where at least 3 family members had AMD; (b) sporadic cases of advanced AMD and (c) cases from the Age-Related Eye Disease Study (AREDS). We investigated polymorphisms and haplotypes in and around the CFH gene to assess their role in AMD. CFH is associated with early/intermediate and advanced AMD in both familial and sporadic cases. In our populations, the CFH SNP, rs2274700, is most strongly associated with AMD and when incorporated into a haplotype with the Y402H SNP and rs1061147, the strongest association is observed (p<10−9). Conclusions/Significance Our results, reproduced in three populations that represent the spectrum of AMD cases, provide evidence that the CFH gene is associated with drusen as well as with advanced AMD. We also identified novel susceptibility and protective haplotypes in the AMD populations.
The particle content of low-power radio galaxies in groups and clusters

The synchrotron-radiating particles and magnetic fields in low-power radio galaxies (including most nearby cluster-centre sources), if at equipartition, can provide only a small fraction of the total internal energy density of the radio lobes or plumes, which is now well constrained via X-ray observations of their external environments. We consider the constraints on models for the dominant energy contribution in low-power radio-galaxy lobes obtained from a detailed comparison of how the internal equipartition pressure and external pressure measured from X-ray observations evolve with distance for two radio galaxies, 3C 31 and Hydra A. We rule out relativistic lepton dominance of the radio lobes, and conclude that models in which magnetic field or relativistic protons/ions carried up the jet dominate lobe energetics are unlikely. Finally, we argue that entrainment of material from the jet surroundings can provide the necessary pressure, and construct a simple self-consistent model of the evolution of the entrainment rate required for pressure balance along the 100-kpc-scale plumes of 3C 31. Such a model requires that the entrained material is heated to temperatures substantially above that of the surrounding intragroup medium, and that the temperature of the thermal component of the jet increases with distance, though remaining sub-relativistic.
Altering the way adolescents attribute negative ambiguous social encounters: a social-cognitive intervention for reducing aggression

ABSTRACT Considerable attention has been given to the study of various dynamics of aggressive behaviour and psychologists have come up with different causal mechanisms explaining aggression. Social scientists need to integrate previous findings and devise intervention plans for the dysfunctional aggression so that deterioration of society can be prevented. The present study was carried out with a purpose of reducing aggressive tendencies by applying social cognitive intervention (SCI). A total of 313 participants with the mean age of 13.60 years (SD = 1.03 years) were administered Aggression Questionnaire. Out of 313 participants, 126 participants scoring high on aggression were screened in and randomly assigned to experimental and control groups. The Experimental group was given a six-session SCI designed specifically to reduce aggression and hostile attribution of intent (HAI). The intervention mainly focused on modifying cognitions and information processing style of aggressive adolescents used by them in ambiguous social situations involving negative outcome. Significant reduction in aggression level and HAI was observed among participants in experimental group as compared with control group. For adolescents at risk, SCI may hold a promise to change information processing patterns and subsequent aggressive tendencies.