Miracle-dz/UniFAR-FTUs huggingface dataset:
Sleep Characteristics, Sleep Problems, and Associations to Quality of Life among Psychotherapists

Sleep problems, especially insomnia, are a common complaint among adults. International studies have shown prevalence rates between 4.7 and 36.2% for sleep difficulties in general, whereas 13.1–28.1% report insomnia symptoms. Sleep problems are associated with lower social and academic performance and can have a severe impact on psychological and physical health. Psychotherapists are suppliers within the public health system. The goal of this study was to outline sleep characteristics, prevalence of sleep problems, insomnia, and associations of quality of life among psychotherapists. A total of 774 psychotherapists (74.7% women; mean age 46 years) participated in the study. Sleep characteristics, sleep problems, well-being, life satisfaction and workload, as well as specific job demands, were assessed via a questionnaire. Analyses revealed that more than 4.2% of the surveyed psychotherapists have difficulties falling asleep, 12.7% often wake up in the night, and 26.6% feel tired, and 3.4% think that their interrupted sleep affects work performance. About 44.1% of them suffer from symptoms of insomnia. Path models showed that insomnia is significantly related to well-being and life satisfaction.
Regulatory T cells/T‐helper cell 17 functional imbalance in uraemic patients on maintenance haemodialysis: A pivotal link between microinflammation and adverse cardiovascular events

Aim: Adverse cardiovascular events resulting from accelerated atherosclerosis are the leading cause of mortality in uraemic patients on maintenance haemodialysis (MHD). Chronic inflammation due to antigen‐specific responses is an important factor in the acceleration of atherosclerosis. The balance between CD4+ CD25+ forkhead/winged helix transcription factor (Foxp3)+ regulatory T cells (Treg) and T helper (Th)17 cells has been reported to play an important role in the development of inflammatory and autoimmune diseases. The aim of the present study was to assess the Treg/Th17 pattern in uraemic patients on MHD and to explore the significance of Treg/Th17 imbalance in the development and outcome of acute cardiovascular events.
Identifying the “truly disadvantaged”

There has been significant interest in examining the developmental factors that predispose individuals to chronic criminal offending. This body of research has identified some social-environmental risk factors as potentially important. At the same time, the research producing these results has generally failed to employ genetically sensitive research designs, thereby potentially generating biased parameter estimates. The current study addresses this gap in the literature by using both a standard social science methodology (SSSM) and two separate genetically informative research designs to examine whether parent, teacher, and peer risk factors are associated with four maladaptive outcomes: arrests, low IQ, reduced self-control, and a combined measure of the “truly disadvantaged. ” Analysis of twin pairs drawn from the National Longitudinal Study of Adolescent to Adult Health revealed that the SSSMs produced upwardly biased estimates of the impact of social-environmental influences on each of the four outcomes. Once genetic factors were controlled, the effect of social-environmental risk was reduced (but remained significant in certain cases). We conclude by discussing these findings in the context of criminal justice policy and their implications for future criminological research.
Reovirus as an oncolytic agent against experimental human malignant gliomas.

BACKGROUND Reovirus is a naturally occurring oncolytic virus that usurps activated Ras-signaling pathways of tumor cells for its replication. Ras pathways are activated in most malignant gliomas via upstream signaling by receptor tyrosine kinases. The purpose of this study was to determine the effectiveness of reovirus as an experimental treatment for malignant gliomas. METHODS We investigated whether reovirus would infect and lyse human glioma cell lines in vitro. We also tested the effect of injecting live reovirus in vivo on human gliomas grown subcutaneously or orthotopically (i.e., intracerebrally) in mice. Finally, reovirus was tested ex vivo against low-passage cell lines derived from human glioma specimens. All P values were two-sided. RESULTS Reovirus killed 20 (83%) of 24 established malignant glioma cell lines tested. It caused a dramatic and often complete tumor regression in vivo in two subcutaneous (P =.0002 for both U251N and U87) and in two intracerebral (P =.0004 for U251N and P =.0009 for U87) human malignant glioma mouse models. As expected, serious toxic effects were found in these severely immunocompromised hosts. In a less immunocompromised mouse model, a single intratumoral inoculation of live reovirus led to a dramatic prolongation of survival (compared with control mice treated with dead virus; log-rank test, P<.0001 for both U251N and U87 cell lines). The animals treated with live virus also appeared to be healthier and gained body weight (P =.0001). We then tested the ability of reovirus to infect and kill primary cultures of brain tumors removed from patients and found that it killed nine (100%) of nine glioma specimens but none of the cultured meningiomas. CONCLUSIONS Reovirus has potent activity against human malignant gliomas in vitro, in vivo, and ex vivo. Oncolysis with reovirus may be a potentially useful treatment for a broad range of human cancers.
Eligibility for hematopoietic stem-cell transplantation for primary systemic amyloidosis is a favorable prognostic factor for survival.

PURPOSE Based on the success of hematopoietic stem-cell transplantation (HSCT) for multiple myeloma, HSCT is being used to treat patients with primary systemic amyloidosis (AL). This article addresses the extent to which eligibility to undergo HSCT is a favorable prognostic feature and explores prognostic factors within the subset of eligible patients. PATIENTS AND METHODS The Mayo Clinic amyloid database was queried for all patients with AL seen at the Mayo Clinic from 1983 through 1997 who would have been eligible for peripheral-blood stem-cell transplantation. Inclusion criteria included biopsy-proven amyloid, symptomatic disease, absence of a clinical diagnosis of multiple myeloma, age < or = 70 years, cardiac interventricular septal thickness < or = 15 mm, cardiac ejection fraction more than 55%, serum creatinine < or = 2 mg/dL, and direct bilirubin < or = 2.0 mg/dL. RESULTS Median age was 56 years (range, 25 to 70) with 79 (34%) older than 60 years. One hundred patients had early cardiac involvement; 41, hepatic involvement; 167, renal involvement; and 39, nerve involvement. The 229 patients have had a median follow-up of 52 months, and 151 have died. The median survival was 42 months with 5- and 10-year survival rates of 36% and 15%, respectively. Important predictors of survival were size of M-component in 24-hour urine, number of involved organs, alkaline phosphatase, performance score, and weight loss. CONCLUSION The same patients who are eligible for HSCT are a good-risk population who do relatively well with chemotherapy (median survival, 42 months), substantially better than the expected median survival of 18 months for all patients with AL. A randomized trial is needed to assess the true effect of HSCT.
Understanding the Impact of Media Engagement on the Perceived Value and Acceptance of Advertising Within Mobile Social Networks

ABSTRACT Mobile social networks (MSNs) have been adopted as an innovative advertising channel. This study proposes a conceptual model to explore the antecedents of MSN engagement and test the relationship between MSN engagement and advertising effectiveness. Results of an online survey discover that utilitarian motivation, mobile convenience, and contextual perceived value (CPV) significantly predict one's engagement with MSN apps. Moreover, MSN engagement positively influences perceived advertising value, which in turn predicts consumers' intention to accept advertisements in MSNs. As the first one to investigate media engagement in the context of mobile social media, this study provides significant implications for both advertising researchers and practitioners.
Studies on connective tissue tumors in the hamster produced by bovine papilloma virus.

Summary Bovine papilloma virus was injected s.c. and intracerebrally in newborn and weanling hamsters. Connective tissue tumors (fibromas, chondromas, and meningiomas) were produced in the subcutaneous regions of the back, pinna of the ear, and the meninges. The tumors did not contain evidence of viral infection when examined by histologic, immunofluorescent, and electron microscopic means. The tumors grew rapidly but remained localized and encapsulated. Large tumors consisted of masses of collagen fibers with a zone of active fibroblasts on the periphery.
D3 is a potent suppressor of interferon gamma-mediated macrophage activation

mediated suppression of macrophage functions is distinct from previously described macrophage deactivation mechanisms. In conclusion, our data indicate that the production of 1 (cid:1) ,25(OH) 2 D 3 by IFN- (cid:2) –stimulated macrophages might be an important negative feedback mechanism to control innate and inﬂammatory responses of activated macrophages. (Blood. 2005;106:4351-4358)
Aging and Capacity in the Same-Different Judgment

ABSTRACT The same-different judgment was used in two experiments to investigate age-group differences in visual processing. Two targets next to fixation were presented; the targets on one-half of the trials were the same, and on the other half of the trials, the targets differed by color, shape, or color and shape (redundant). Response times were lower for redundant trials than for color-only and shape-only trials; this redundancy gain was greater for older observers than for young observers. Capacity measures based on the integrated hazard functions indicated that young adults, but not older adults, experienced a slowing of processing (reduction of capacity) in the redundant condition. These capacity measures may provide a method for interpreting age-group effects in the presence of overall response-time differences.
Weighted Matchings for Preconditioning Symmetric Indefinite Linear Systems

Maximum weight matchings have become an important tool for solving highly indefinite unsymmetric linear systems, especially in direct solvers. In this study we investigate the benefit of reorderings and scalings based on symmetrized maximum weight matchings as a preprocessing step for incomplete $\mathrm{LDL^T}$ factorizations. The reorderings are constructed such that the matched entries form $1 \times 1$ or $2 \times 2$ diagonal blocks in order to increase the diagonal dominance of the system. During the incomplete factorization only tridiagonal pivoting is used. We report results for this approach and comparisons with other solution methods for a diverse set of symmetric indefinite matrices, ranging from nonlinear elasticity to interior point optimization.
Import Kidney Transplants from Nonmandatory Share Deceased Donors: Characteristics, Distribution and Outcomes

Outcomes of locally rejected kidneys transplanted at other centers (import KTX) are unknown. SRTR data from 2000 to 2009 of deceased‐donor KTXs excluding 0‐mismatch, paybacks, and other mandatory shares were compared by location of KTX at local (n = 48 165), regional (n = 4428) or national (n = 4104) centers using multivariable regression models. Compared to nonmandatory share local transplants, import KTX were associated with significantly higher overall risks of patient death (regional aHR 1.15, p < 0.01; national aHR 1.14, p < 0.01), and graft failure (regional aHR 1.17, p < 0.01; national aHR1.21, p < 0.01). In paired analysis, the risk of delayed graft function (DGF) for import KTX was higher compared to locally transplanted mates (regional aOR 1.53, p < 0.01, national aOR 2.14, p < 0.01); however, despite longer ischemia times, overall graft survival was similar. Mean cold ischemia times (CIT) pre‐ and post‐DonorNet® were similar for local and regional transplants, but significantly higher for national transplants (28.9 ± 9.9 vs. 29.9 ± 9.7 h, respectively, p = 0.01). Import KTX is associated with increased risks of graft failure, patient death and DGF. In the era of DonorNet® cold ischemia times of kidneys imported to regional centers are not improved compared to pre‐DonorNet®; and, those of national centers are significantly prolonged.
Circles of Support and Accountability for Sex Offenders: A Systematic Review of Outcomes

We conducted a systematic review of studies reporting on the effectiveness of Circles of Support and Accountability (Circles). Circles use volunteers to provide support for sex offenders living in the community. We searched 10 databases up to the end of 2013 and identified 3 relevant outcome studies. An additional 12 papers or reports were identified by searching reference lists, Google, and contacting key authors and Circles providers to obtain unpublished data. These 15 studies comprised one randomized controlled trial, three retrospective cohorts with matched controls, and 11 case series. The majority reported measures of recidivism, particularly reconviction. The 4 studies with controls generally reported that participation in Circles was associated with lower recidivism although there were few statistically significant differences. Few studies examined changes in risk or psychosocial outcomes. A number of methodological issues are discussed. Longer term, prospective follow-up studies with control groups are required to address these issues.
Discordance between genotypic resistance and pseudovirus phenotypic resistance in AIDS patients after long‐term antiretroviral therapy and virological failure

Sixteen original recombinant pseudoviruses were generated by cloning the reverse transcriptase and protease genes of human immunodeficiency virus (HIV)‐1 from patients into a plasmid vector (pNL4‐3‐ΔE‐EGFP). By site‐directed mutagenesis two restriction endonuclease sites, ApaI and AgeI, were inserted into pNL4‐3‐ΔE‐EGFP. Phenotypic susceptibility of recombinant pseudoviruses to five different classes of antiretroviral drugs was determined using a luciferase reporter assay system. The results were subjected to comparative analyses to detect genotype–phenotype associations. Among 16 strains tested, 12 strains had a discordant genotype–phenotype resistance pattern to at least one drug. In five strains resistance to two, in two strains to three, and in one strain resistance to four drugs was detected. HIV resistance genotyping could predict the phenotype for nevirapine and azidothymidine. For lamivudine, 2′‐3′‐didehydro‐2′‐3′dideoxythymidine and didanosine, phenotypic resistance testing was necessary. The study showed that in patients who experienced long‐term highly active antiretroviral therapy and virological failure, there is some discordance between genotypic and phenotypic HIV drug resistance. To address the issue of limited resources in China, genotypic and phenotypic resistance testing should be done for different drugs in order to guide clinical therapy more effectively.
A Framework for Understanding Community Colleges’ Organizational Capacity for Data Use

This convergent parallel design mixed methods case study of four community colleges explores the relationship between organizational capacity and implementation of data-driven decision making (DDDM). The article also illustrates purposive sampling using replication logic for cross-case analysis and the strengths and weaknesses of quantitizing qualitative data in a mixed methods design. The findings suggest that community colleges’ organizational capacity for data-driven decision making is a function of human and social capital, but not physical capital. Methodologically, the data analyses suggest that researchers considering quantitizing qualitative data should consider an exploratory sequential design to better understand the phenomenon under study before reducing qualitative data to numbers.
Use of Piezoelectric Immunosensors for Detection of Interferon-Gamma Interaction with Specific Antibodies in the Presence of Released-Active Forms of Antibodies to Interferon-Gamma

In preliminary ELISA studies where released-active forms (RAF) of antibodies (Abs) to interferon-gamma (IFNg) were added to the antigen-antibody system, a statistically significant difference in absorbance signals obtained in their presence in comparison to placebo was observed. A piezoelectric immunosensor assay was developed to support these data and investigate the effects of RAF Abs to IFNg on the specific interaction between Abs to IFNg and IFNg. The experimental conditions were designed and optimal electrode coating, detection circumstances and suitable chaotropic agents for electrode regeneration were selected. The developed technique was found to provide high repeatability, intermediate precision and specificity. The difference between the analytical signals of RAF Ab samples and those of the placebo was up to 50.8%, whereas the difference between non-specific controls and the placebo was within 5%–6%. Thus, the piezoelectric immunosensor as well as ELISA has the potential to be used for detecting the effects of RAF Abs to IFNg on the antigen-antibody interaction, which might be the result of RAF’s ability to modify the affinity of IFNg to specific/related Abs.
Can Radiology Play a Role in Early Diagnosis of Dengue Fever?

Background: Dengue fever (DF) is a viral hemorrhagic fever causing severe morbidity and mortality in affected patients. Aims: The purpose of our study was to evaluate the changing trends in radiological findings in DF, to find if ultrasound is useful in the diagnosis of DF during an epidemic in absence of serological tests, and also to investigate the effects of DF in pregnancy. Materials and Methods: A prospective study was conducted in 2013 comprising of 400 patients who were serologically positive for dengue. Out of these, radiological investigations were conducted for 107 patients who were analyzed. Results: Out of the 107 patients, 85 patients underwent ultrasound, 12 computed tomography (CT) scans of brain or paranasal sinuses, and 21 chest radiography. The maximum numbers of patients (79%) were in the age group of 20-50 years. The most common ultrasound finding was hepatomegaly that was seen in 62% of the patients. Other findings were splenomegaly (45%), gallbladder (GB) wall edema (45%), right-sided pleural effusion (37%), bilateral pleural effusion (22%), and ascites (36%). Out of 10 pregnant patients, 5 had oligohydramnios, 2 had intrauterine growth restriction, 2 had intrauterine fetal demise, and 5 had a normal antenatal ultrasound. Conclusion: Ultrasound findings of hepatosplenomegaly, GB wall edema, right-sided or bilateral pleural effusion, and ascites in patients presenting with signs and symptoms of DF during an epidemic are virtually diagnostic of DF. There have been recent changing trends with hepatosplenomegaly being the more common manifestation, in comparison to ascites and GB wall edema. DF also has catastrophic effects in pregnancy such as oligohydramnios and intrauterine fetal demise.
Professionalism Deficiencies in a First-Quarter Doctor–Patient Relationship Course Predict Poor Clinical Performance in Medical School

Background. The purpose of this study was to determine whether four types of professionalism deficiencies in medical students identified during a first-year course on doctor–patient relationships might predict poor performance in third-year clerkships. Method. Preceptors identified students who had deficiencies in interviewing patients: extreme shyness, poor process skills, paternalism, or a negative attitude toward interviewing. Deficient students were matched by academic ability to a control group. Performance on third-year clerkships was compared. Results. Students with paternalistic behavior or negative attitudes had significantly lower third-year grades. Conclusions. Professionalism deficiencies that result in the inability of the student to establish patient rapport are detectable early and predict problems in future clinical performance.
Screen for child anxiety‐related emotional disorders (SCARED): Convergent and divergent validity

The purpose of this study was to examine the Screen for Child Anxiety‐Related Emotional Disorders’ (SCARED) divergent and convergent validity and its ability to identify anxious children. The SCARED, the Child Behaviour Checklist (CBCL), and the State‐Trait Anxiety Inventory for Children (STAIC) were administered to children, adolescents (n = 295), and their parents attending an outpatient mood and anxiety disorders clinic. DSM‐IIIR/IV diagnoses were made using a semistructured interview (n = 130) or a symptom checklist (n = 165). The Multi‐Trait Multi‐Method Matrix was used to assess construct validity, and Receiver Operating Curve analysis was used to assess the sensitivity and specificity of the SCARED, CBCL, and STAIC. The SCARED correlated significantly better with the CBCL’s internalizing factors than with the externalizing factors. In addition, parent and child forms of the SCARED correlated significantly with the trait and state subscales of the STAIC. Children with an anxiety disorder scored significantly higher on the SCARED than children with depression only or disruptive disorders only (P < 0.05), thus demonstrating the discriminant validity of the SCARED. The SCARED is a reliable and valid screening tool for clinically referred children and adolescents with anxiety disorders. Depression and Anxiety 12:85–91, 2000. © 2000 Wiley‐Liss, Inc.
On the Constant Modulus Criterion: A New Algorithm

In this paper, we propose a new iterative algorithm for the minimization of the constant modulus (CM) criterion. It is composed of two stages: Prewhitening followed by complex Givens rotations, whence the name Givens CMA (GCMA). Initially, prewhitening reduces the channel matrix into a unitary matrix. Subsequently, this unitary matrix is computed via complex Givens rotations by minimizing the CM criterion. The proposed algorithm provides similar or even better performance than the Analytical CMA (ACMA) algorithm at reduced computational cost. Some simulation results are provided to illustrate the effectiveness of the proposed algorithm.
Using the TechnoWellness Inventory (TWI) to Examine and Apply a New Wellness Construct

ABSTRACT The purpose of this study was to operationalize TechnoWellness by designing an assessment instrument, the TechnoWellness Inventory (TWI), and to explore the relationship between individuals’ TechnoWellness and their holistic wellness. Exploratory factor analysis (N = 312) supported a 76-item instrument with five subscales. Although the TWI factors did not correspond to factors in the Indivisible Self wellness model, regression analyses indicated that scores on the TWI and three TWI scales predicted holistic wellness.
Journal of Internet Banking and Commerce a Comparative Study of Online P2p Lending in the Usa and China

research has focused on globalization, IT in supply chain management, and manufacturing industries. Abstract Peer-to-Peer (P2P) lending provides online users an innovative loaning and investment vehicle without the intermediation of financial institutions. However, the research on online P2P lending is still scarce. In this study we review relevant literature and conduct a comparative study of online P2P lending practices in the USA and China. We find that two categories of credit information, " hard " and " soft " information, may have profound influences on lending outcomes in both countries, but lenders in China is more reliable on " soft " information. This study provides valuable insights for future research and practices and enriches the understanding of online P2P lending across countries.