Miracle-dz/UniFAR-FTUs huggingface dataset:
The Related Risk Factors Analysis of Snake-Bite Induced Acute Kidney Injury

Background The pathogenic mechanism of snake-bite induced acute kidney injury (AKI) remains unclear. Analyzing the risk factors for snake-bite induced AKI may provide the guidance needed for AKI prevention and early treatment. Material/Methods This retrospective study included 119 snake-bite patients who were hospitalized at the emergency department of Sichuan Provincial People’s Hospital from January 2011 to September 2013. The patients were divided into AKI and non-AKI groups according to the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guideline. Gender, age, and clinical examination data of the patients were recorded. The Mann-Whitney U test and Fisher exact test were performed to analyze the collected data; preliminary analysis of independent risk factors was performed with multivariate logistic regression. Results Among the snake-bite patients, 98.3% were farmers. The mean age of patients was 46±12 years. Of the 119 patients (13.4%), 16 suffered from AKI. There were statistically significant differences between the AKI and non-AKI groups with respect to age, time interval from snake bite to antivenin therapy, creatine kinase, blood myoglobin, advanced age, regional lymphadenopathy, incision drainage, and hemoglobin. Preliminary analysis with multivariate logistic regression showed that advanced age and increased time interval from snake bite to antivenin therapy might be independent risk factors for snake-bite induced AKI. Conclusions Age, time interval from snake bite to antivenin therapy, creatine kinase, blood myoglobin, advanced age, regional lymphadenopathy, incision drainage, and hemoglobin were risk factors for snake-bite induced AKI. Advanced age and delayed antivenin therapy might be independent risk factors for snake-bite induced AKI.
Data Dissemination with Ring-Based Index for Wireless Sensor Networks

In wireless sensor networks, sensor nodes are capable of not only measuring real world phenomena, but also storing, processing, and transferring these measurements. Many techniques have been proposed for disseminating sensing data. However, most of them are not efficient in the scenarios where a huge amount of sensing data are generated, but only a small portion of them are queried. In this paper, we first propose an index-based data dissemination scheme to address the problem. With this scheme, sensing data are collected, processed, and stored at the nodes close to the detecting nodes, and the location information of these storing nodes is pushed to some index nodes, which act as the rendezvous points for sinks and sources. To address the issues of fault tolerance and load balance, we extend the scheme with an adaptive ring-based index (ARI) technique in which the index nodes for one event type form a ring surrounding the location which is determined by the event type, and the ring can be dynamically reconfigured. Considering that frequently updating or querying index nodes may cause high overhead, we also propose a lazy index updating (LIU) mechanism and a lazy index querying (LIQ) mechanism to reduce the overhead. Analysis and simulations are conducted to evaluate the performance of the proposed scheme. The results show that the proposed scheme outperforms the external storage-based scheme, the DCS scheme, and the local storage-based schemes with flood-response style. The results also show that using ARI can tolerate clustering failures and achieve load balance and using LIU (LIQ) can further improve the system performance. is pushed to some index nodes,
Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.

BACKGROUND alpha(1)-adrenergic receptors (alpha(1)ARs) regulate blood pressure, regional vascular resistance, and venous capacitance; the exact subtype (alpha(1a), alpha(1b), alpha(1 d)) mediating these effects is unknown and varies with species studied. In order to understand mechanisms underlying cardiovascular responses to acute stress and chronic catecholamine exposure (as seen with aging), we tested two hypotheses: (1) human alpha(1)AR subtype expression differs with vascular bed, and (2) age influences human vascular alpha(1)AR subtype expression. METHODS AND RESULTS Five hundred vessels from 384 patients were examined for alpha(1)AR subtype distribution at mRNA and protein levels (RNase protection assays, ligand binding, contraction assays). Overall vessel alpha(1)AR density is 16+/-2.3fmol/mg total protein. alpha(1a)AR predominates in arteries at mRNA (P<0.001) and protein (P<0.05) levels; all 3 subtypes are present in veins. Furthermore, alpha(1)AR mRNA subtype expression varies with vessel bed (alpha(1a) higher in splanchnic versus central arteries, P<0.05); competition analysis (selected vessels) and functional assays demonstrate alpha(1a) and alpha(1b)-mediated mammary artery contraction. Overall alpha(1)AR expression doubles with age (<55 versus > or = 65 years) in mammary artery (no change in saphenous vein), accompanied by increased alpha(1b)>alpha(1a) expression (P< = 0.001). CONCLUSIONS Human vascular alpha(1)AR subtype distribution differs from animal models, varies with vessel bed, correlates with contraction in mammary artery, and is modulated by aging. These findings provide potential novel targets for therapeutic intervention in many clinical settings.
Age-Dependent Effects of Oxytocin and Oxytocin Receptor Antagonists on Bladder Contractions: Implications for the Treatment of Overactive Bladder Syndrome

Overactive bladder (OAB) is an age-related disorder characterised by unstable bladder contractions resulting in disruptive lower urinary tract symptoms (LUTS), thus creating a profound impact on an individual’s quality of life. The development of LUTS may be linked to the overexpression of oxytocin receptors (OXTRs) within the bladder detrusor muscle, resulting in increased baseline myogenic tone. Thus, it is hypothesised that targeting OXTRs within the bladder using oxytocin antagonists may attenuate myogenic tone within the bladder, thereby providing a new therapeutic avenue for treating OAB. Organ bath contractility and immunohistochemistry techniques were conducted on bladder tissue sourced from young rats (7–8 weeks and 10–12 weeks) and older rats (4–5 months and 7–9 months). Organ bath studies revealed that oxytocin (OT) significantly increased bladder contractions, which were significantly attenuated by [β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-Me-Tyr2, Orn8]-Oxytocin) (1 µM) (**** p < 0.0001) and atosiban (10 µM) in both young and older rats (** p < 0.01); in contrast, cligosiban (1 µM and 10 µM) did not inhibit OT-induced contractions in both young and older rats (p ≥ 0.05). Interestingly, cligosiban (1 µM and 10 µM) significantly reduced the frequency of spontaneous contractions within the bladder of both young (*** p < 0.001) and older rats (**** p < 0.0001), while atosiban (10 µM) only demonstrated this effect in older rats (** p < 0.01). Furthermore, immunohistochemistry (IHC) analysis revealed significant colocalization of nuclear-specific oxytocin receptors (OXTRs) in the contractile (smooth muscle) cells within young (** p < 0.01) and older rats (* p < 0.05), indicating OT may be a key modulator of bladder contractility.
A fast target localization method with multi-point observation for a single UAV

To resolve the problems existing in the target localization methods at present, such as accuracy, real-time need or cost, a fast localization method with a single Unmanned Aerial Vehicle(UAV) is proposed in the paper. When flying along the expected trajectory, multi-point observation of the target can be got, even with a single UAV. Multiple rays from the observation point to the target can be got, which can form a certain region when intersecting with a special horizontal plane. To estimate the height of the target, the steepest descent method with the Armijo searching algorithm is adopted, with the criterion that the area of the certain region is minimal. When the height information is got, the exact position of the target can be computed. There is no need to acquire the height information of the target in advance, which can make the method useful in different conditions. The accuracy and feasibility of the method are verified by experiments.
The sedentary office: an expert statement on the growing case for change towards better health and productivity

An international group of experts convened to provide guidance for employers to promote the avoidance of prolonged periods of sedentary work. The set of recommendations was developed from the totality of the current evidence, including long-term epidemiological studies and interventional studies of getting workers to stand and/or move more frequently. The evidence was ranked in quality using the four levels of the American College of Sports Medicine. The derived guidance is as follows: for those occupations which are predominantly desk based, workers should aim to initially progress towards accumulating 2 h/day of standing and light activity (light walking) during working hours, eventually progressing to a total accumulation of 4 h/day (prorated to part-time hours). To achieve this, seated-based work should be regularly broken up with standing-based work, the use of sit–stand desks, or the taking of short active standing breaks. Along with other health promotion goals (improved nutrition, reducing alcohol, smoking and stress), companies should also promote among their staff that prolonged sitting, aggregated from work and in leisure time, may significantly and independently increase the risk of cardiometabolic diseases and premature mortality. It is appreciated that these recommendations should be interpreted in relation to the evidence from which they were derived, largely observational and retrospective studies, or short-term interventional studies showing acute cardiometabolic changes. While longer term intervention studies are required, the level of consistent evidence accumulated to date, and the public health context of rising chronic diseases, suggest initial guidelines are justified. We hope these guidelines stimulate future research, and that greater precision will be possible within future iterations.
X‐Band Radar Mapping of Morphological Changes at a Dynamic Coastal Inlet

Remote sensing of the complex interactions between bathymetry, tidal flow, and waves in coastal inlets provides high‐resolution data sets that can be exploited to characterize the morphological variability of shallow ebb tidal deltas (ETD). Here we used observations from a mobile X‐band radar platform to determine optimal conditions during which radar‐derived shoal signatures best represent positions of underlying shoals. Significant increases in the spatial errors of radar shoal signatures were observed when offshore wave energy intensified. Consequently, the lowest spatial errors occurred when the radar shoal signatures were primarily a function of the tidal flow (i.e., low sea state). We used these findings to quantify shoal migration patterns at the New River Inlet, North Carolina. We found that the southwestern portion of the ETD had the largest morphological variability with typical shoreward migration rates of 2–3 m/day driven by incident wave energy. The migration rates and patterns estimated from X‐band observations were consistent with numerical modeling results and a previous video‐based New River remote sensing study. Our results confirm that X‐band radar can be used to quickly map shallow ETDs (e.g., 5 min of observations), allowing for rapid morphological assessments from shore or boat‐based platforms. The methods would prove particularly useful for initial assessment as well as continual monitoring of dynamic tidal inlets where large morphological responses can be rapidly assessed and used for geomorphological studies, and as decision aids for maritime or engineering operations.
Adaptive significance of quorum sensing-dependent regulation of public goods by integration of growth rate: a trade-off between survival and efficiency

Quorum sensing (QS) is a mechanism of communication used by bacteria to monitor cell density and coordinate cooperative behaviors. An emerging framework is that the adaptive significance of QS in regulation of production of costly extracellular metabolites (public goods) is to maintain the homeostasis of cooperation. We investigated the functionality of QS-dependent regulation of rhamnolipids, extracellular surface-active glycolipids promoting the social swarming motility behavior, in Burkholderia glumae and found that QS is superfluous under rich nutritional conditions. In contrast, decreasing nutrient concentrations to reduce the growth rate amplifies rhamnolipid biosynthesis gene expression, revealing a system where QS-dependent regulation is triggered by the growth rate of the population rather than by its cell density. Our results provide evidence that the adaptive significance of QS in regulation of public goods is to maintain an optimized demand-driven supply of target cooperative behavior, wherein efficiency can be traded off against survival.
IgE-Induced Mast Cell Survival Requires the Prolonged Generation of Reactive Oxygen Species1

We show in this study that the ability of five different monomeric IgEs to enhance murine bone marrow-derived mast cell (BMMC) survival correlates with their ability to stimulate extracellular calcium (Ca2+) entry. However, whereas IgE+Ag more potently stimulates Ca2+ entry, it does not enhance survival under our conditions. Exploring this further, we found that whereas all five monomeric IgEs stimulate a less robust Ca2+ entry than IgE+Ag initially, they all trigger a more prolonged Ca2+ influx, generation of reactive oxygen species (ROS), and ERK phosphorylation. These prolonged signaling events correlate with their survival-enhancing ability and positively feedback on each other to generate the prosurvival cytokine, IL-3. Interestingly, the prolonged ERK phosphorylation induced by IgE appears to be regulated by a MAPK phosphatase rather than MEK. IgE-induced ROS generation, unlike that triggered by IgE+Ag, is not mediated by 5-lipoxygenase. Moreover, ROS inhibitors, which block both IgE-induced ROS production and Ca2+ influx, convert the prolonged ERK phosphorylation induced by IgE into the abbreviated phosphorylation pattern observed with IgE+Ag and prevent IL-3 generation. In support of the essential role that IgE-induced ROS plays in IgE-enhanced BMMC survival, we found the addition of H2O2 to IgE+Ag-stimulated BMMCs leads to IL-3 secretion.
Metagenomic Analysis Indicates Epsilonproteobacteria as a Potential Cause of Microbial Corrosion in Pipelines Injected with Bisulfite

Sodium bisulfite (SBS) is used as an oxygen scavenger to decrease corrosion in pipelines transporting brackish subsurface water used in the production of bitumen by steam-assisted gravity drainage. Sequencing 16S rRNA gene amplicons has indicated that SBS addition increased the fraction of the sulfate-reducing bacteria (SRB) Desulfomicrobium, as well as of Desulfocapsa, which can also grow by disproportionating sulfite into sulfide, sulfur, and sulfate. SRB use cathodic H2, formed by reduction of aqueous protons at the iron surface, or use low potential electrons from iron and aqueous protons directly for sulfate reduction. In order to reveal the effects of SBS treatment in more detail, metagenomic analysis was performed with pipe-associated solids (PAS) scraped from a pipe section upstream (PAS-616P) and downstream (PAS-821TP) of the SBS injection point. A major SBS-induced change in microbial community composition and in affiliated hynL genes for the large subunit of [NiFe] hydrogenase was the appearance of sulfur-metabolizing Epsilonproteobacteria of the genera Sulfuricurvum and Sulfurovum. These are chemolithotrophs, which oxidize sulfide or sulfur with O2 or reduce sulfur with H2. Because O2 was absent, this class likely catalyzed reduction of sulfur (S0) originating from the metabolism of bisulfite with cathodic H2 (or low potential electrons and aqueous protons) originating from the corrosion of steel (Fe0). Overall this accelerates reaction of of S0 and Fe0 to form FeS, making this class a potentially powerful contributor to microbial corrosion. The PAS-821TP metagenome also had increased fractions of Deltaproteobacteria including the SRB Desulfomicrobium and Desulfocapsa. Altogether, SBS increased the fraction of hydrogen-utilizing Delta- and Epsilonproteobacteria in brackish-water-transporting pipelines, potentially stimulating anaerobic pipeline corrosion if dosed in excess of the intended oxygen scavenger function.
Automatic Pronunciation Assessment for Mandarin Chinese: Approaches and System Overview

This paper presents the algorithms used in a prototypical software system for automatic pronunciation assessment of Mandarin Chinese. The system uses forced alignment of HMM (Hidden Markov Models) to identify each syllable and the corresponding log probability for phoneme assessment, through a ranking-based confidence measure. The pitch vector of each syllable is then sent to a GMM (Gaussian Mixture Model) for tone recognition and assessment. We also compute the similarity of scores for intensity and rhythm between the target and test utterances. All four scores for phoneme, tone, intensity, and rhythm are parametric functions with certain free parameters. The overall scoring function was then formulated as a linear combination of these four scoring functions of phoneme, tone, intensity, and rhythm. Since there are both linear and nonlinear parameters involved in the overall scoring function, we employ the downhill Simplex search to fine-tune these parameters in order to approximate the scoring results obtained from a human expert. The experimental results demonstrate that the system can give consistent scores that are close to those of a human's subjective evaluation.
Mkrn3 functions as a novel ubiquitin E3 ligase to inhibit Nptx1 during puberty initiation

Central precocious puberty (CPP) is attributed to the disorder of some trigger factors those can activate the hypothalamic-pituitary-gonadal axis controlled by GnRH neurons. Many recent studies reveal one of those trigger factors, Makorin ring finger protein 3 (Mkrn3), whose loss-of-function mutations are implicated in CPP. Although Mkrn3 contained zinc Ring finger domain is considered as a putative E3 ubiquitin ligase, its actual function is never reported. Here, our results demonstrated that in mice hypothalamus before and when puberty initiated, Mkrn3 expressed the reversed tendency with Nptx1, which is an important secreted protein for neuron development. Furthermore, our data manifested that Mkrn3 interacted and suppressed Nptx1 activity. And the Ring finger domain of Mkrn3 contained was determined to be essential for binding with Nptx1 for its polyubiquitination during the puberty initiation. Our study shed light on the molecular insights into the function of Mkrn3 in the events of puberty initiation.
Rewrite techniques for transitive relations

We propose inference systems for dealing with transitive relations in the context of resolution-type theorem proving. These inference mechanisms are based on standard techniques from term rewriting and represent a refinement of chaining methods. We establish their refutational completeness and also prove their compatibility with the usual simplification techniques used in rewrite-based theorem provers. A key to the practicality of chaining techniques is the extent to which so-called variable chainings can be restricted. We demonstrate that rewrite techniques considerably restrict variable chaining, though we also show that they cannot be completely avoided for transitive relations in general. If the given relation satisfies additional properties, such as symmetry, further restrictions are possible. In particular, we discuss (partial) equivalence relations and congruence relations. <<ETX>>
Multiple mantle metasomatism beneath the Leizhou Peninsula, South China: evidence from elemental and Sr-Nd-Pb-Hf isotope geochemistry of the late Cenozoic volcanic rocks

ABSTRACT We analysed whole-rock major and trace elements and Sr-Nd-Pb-Hf isotopes of the late Cenozoic volcanic rocks in the Leizhou Peninsula, South China to investigate their mantle source characteristics. These volcanic rocks, collected from Jiujiang, Tianyang and Huoju areas of the Leizhou Peninsula, are characterized by incompatible element enrichment but variable isotopic depletion. The volcanic rocks from Jiujiang and Tianyang show prominent primitive-mantle-normalized positive Nb, Ta and Sr anomalies and depleted Sr-Nd-Pb-Hf isotope compositions, whereas those from Huoju show slight positive to negative Nb and Ta anomalies, a prominent positive Pb anomaly, and more enriched Sr-Nd-Pb-Hf isotope compositions. Two types of mantle metasomatism are required to explain the geochemical characteristics of these rocks. The Jiujiang and Tianyang samples were largely derived from a mantle source metasomatized recently by a low-F melt. Such low-F melt is generated within the asthenospheric mantle, which is enriched in volatiles and incompatible elements with positive Sr anomaly and depleted Sr-Nd-Pb-Hf isotope compositions. The Huoju samples were largely derived from a mantle source metasomatized by recycled upper continental crust material. These two types of mantle metasomatism beneath the Leizhou Peninsula are consistent with trace element characteristics of mantle mineralogy (e.g. clinopyroxene vs. amphibole), which reflects source evolution in space and time (e.g. tectonic setting change).
Maintaining Shortest Paths Under Deletions in Weighted Directed Graphs

We present an improved algorithm for maintaining all-pairs $(1 + \epsilon)$ approximate shortest paths under deletions and weight-increases. The previous state of the art for this problem is total update time $\widetilde{O}(n^2\sqrt{m}/\epsilon)$ over all updates for directed unweighted graphs [S. Baswana, R. Hariharan, and S. Sen, J. Algorithms, 62 (2007), pp. 74--92], and $\widetilde{O}(mn/\epsilon)$ for undirected unweighted graphs [L. Roditty and U. Zwick, in Proceedings of the 45th FOCS, Rome, Italy, 2004, pp. 499--508]. Both algorithms are randomized and have constant query time. Very recently, Henzinger, Krinninger, and Nanongkai presented a deterministic version of the latter algorithm [M. Henzinger, S. Krinninger, and D. Nanongkai, in IEEE FOCS, 2013, pp. 538--547]. Note that $\widetilde{O}(mn)$ is a natural barrier because even with a $(1 + \epsilon)$ approximation, there is no $o(mn)$ combinatorial algorithm for the static all-pairs shortest path problem. Our algorithm works on directed weighte.
Presence of Selected Methanogens, Fibrolytic Bacteria, and Proteobacteria in the Gastrointestinal Tract of Neonatal Dairy Calves from Birth to 72 Hours

The microbial communities in the gastrointestinal tract of a young calf are essential for the anatomical and physiological development that permits a transition from milk to solid feed. Selected methanogens, fibrolytic bacteria, and proteobacteria were quantified in the rumen fluid and tissue, abomasum fluid, cecum fluid and tissue, and feces of Holstein bull calves on day 0 (0–20 mins after birth), day 1 (24 ± 1 h after birth), day 2 (48 ± 1 h after birth), and day 3 (72 ± 1 h after birth). Methanogens, fibrolytic bacteria, and Geobacter spp. were found to be already present from birth, indicating that microbial colonization of the gastrointestinal tract occurred before or during delivery. The abundance of methanogens and Geobacter spp. differed between the days tested and between compartments of the digestive tract and feces, but such difference was not observed for fibrolytic bacteria. Our findings suggests that methanogens might have an alternative hydrogen provider such as Geobacter spp. during these early stages of postnatal development. In addition, fibrolytic bacteria were present in the rumen well before the availability of fibrous substrates, suggesting that they might use nutrients other than cellulose and hemicellose.