Miracle-dz/UniFAR-FTUs huggingface dataset:
Usefulness of anti-ulcer drugs for the prevention and treatment of peptic ulcers induced by low doses of aspirin.

AIM To investigate the usefulness of anti-ulcer drugs for the prevention and treatment of low-dose aspirin-induced peptic ulcer. METHODS Upper gastrointestinal endoscopy was performed in 68 patients receiving daily low-dose aspirin (81 or 100 mg/day). The endoscopic findings were classified according to the Lanza score, and the scores were compared between groups categorized according to the concomitant use of anti-ulcer drugs and the types of drugs used. In another study, 31 hemorrhagic peptic ulcer patients who had been receiving low-dose aspirin were enrolled. The patients were randomly classified into the proton pump inhibitor (PPI)-treated group and the H2 receptor antagonist (H2RA)-treated group. The administration of low-dose aspirin was continued concomitantly, and endoscopic examinations were performed 8 wk later. RESULTS The Lanza scores (mean +/- SD) of the gastro-mucosal lesions were 1.0 +/- 1.9 and 1.9 +/- 2.3 in 8 and 16 patients receiving prevention therapy with a PPI and an H2RA, respectively. Both scores were significantly smaller than the scores in 34 patients who were not receiving prevention therapy (4.7 +/- 1.0) and in 10 patients receiving cytoprotective anti-ulcer drugs (4.3 +/- 1.6). In the prospective study, 18 and 13 patients received a PPI and an H2RA, respectively. Endoscopic examinations revealed that the tissue in the region of the gastro-mucosal lesions had reverted to normal in all patients in the PPI-treated group and in 12 patients (92%) in the H2RA-treated group; no significant differences were observed between the groups. CONCLUSION H2RA therapy was effective for both the prevention and treatment of low-dose aspirin-induced peptic ulcer, similar to the effects of PPIs, while cytoprotective anti-ulcer drugs were ineffective in preventing ulceration.
Language and Self-Construal Priming

Previous research has argued that language serves as a cognitive cue to reinforce culturally normative self-construals. We hypothesize that language-priming effects would be stronger for women than men and that they would primarily occur for self-construals that are not already latently salient in the respondents’ culture. Also, in contrast to earlier research on language priming of self-construals, we rely on Singelis’s independent and interdependent self-construal scales as closed-ended dependent measures. Using a bilingual sample from Hong Kong (n = 126), we experimentally varied questionnaire language (English vs. Chinese) and found support for all our predictions. The discussion focuses on cue strength as moderator of language-priming effects.
A Double‐Blind Comparison of Cimetidine and Ranitidine as Prophylaxis against Gastric Aspiration Syndrome

Preoperative cimetidine, ranitidine, or placebo were administered, orally or intravenously, to 190 patients in a double-blind study. The volume and pH of gastric aspirate samples, obtained after tracheal intubation and before extubation, were measured. Both cimetidine and ranitidine produced higher mean pH levels and thus fewer patients “at risk” should gastric aspiration occur (pH ≤ 2.5) than did placebo. Intravenous ranitidine (in both 40− and 80-mg doses) produced fewer patients at risk in the event gastric aspiration should occur than did cimetidine, 300 mg, and the 80-mg dose produced a higher mean pH level. Oral ranitidine, 150 mg, produced a significantly higher mean pH level than did oral cimetidine, 300 mg, and tended to give fewer patients at risk. The volumes of gastric contents aspirated were similar following each of the drugs except that the volume was significantly less two hours following oral ranitidine, 150 mg, than after oral cimetidine, 300 mg.
Trust and Truth

In a laboratory experiment, we create relationships between pairs of anonymous subjects through a Prisoners' dilemma game. Thereafter the same subjects play a private values (sealed-bid double auction) bargaining game with or without communication. Communication substantially increases bargaining efficiency among subjects who cooperated in the Prisoners' dilemma, but has no significant effect on bargaining outcomes when one subject defected. Subjects who cooperated in the Prisoners' dilemma bid more aggresively if their opponent defected. Cooperators also lie more about their valuations when their opponent defected: Compared to the case of mutual cooperation, the cooperators' rate of honest revelation decreases from 64% to 6% and the rate of outright deception increases from 7% to 53%. Our results provide qualitatively new evidence that many people are strong recipricators: They are willing to bear private costs in order to reward good behavior and punish bad behavior, even when the rewards and punishments are unobservable.
What influences dwell time during source code reading?: analysis of element type and frequency as factors

While knowledge about reading behavior in natural-language text is abundant, little is known about the visual attention distribution when reading source code of computer programs. Yet, this knowledge is important for teaching programming skills as well as designing IDEs and programming languages. We conducted a study in which 15 programmers with various expertise read short source codes and recorded their eye movements. In order to study attention distribution on code elements, we introduced the following procedure: First we (pre)-processed the eye movement data using log-transformation. Taking into account the word lengths, we then analyzed the time spent on different lexical elements. It shows that most attention is oriented towards understanding of identifiers, operators, keywords and literals, relatively little reading time is spent on separators. We further inspected the attention on keywords and provide a description of the gaze on these primary building blocks for any formal language. The analysis indicates that approaches from research on natural-language text reading can be applied to source code as well, however not without review.
Large-scale computation of elementary flux modes with bit pattern trees

MOTIVATION Elementary flux modes (EFMs)--non-decomposable minimal pathways--are commonly accepted tools for metabolic network analysis under steady state conditions. Valid states of the network are linear superpositions of elementary modes shaping a polyhedral cone (the flux cone), which is a well-studied convex set in computational geometry. Computing EFMs is thus basically equivalent to extreme ray enumeration of polyhedral cones. This is a combinatorial problem with poorly scaling algorithms, preventing the large-scale analysis of metabolic networks so far. RESULTS Here, we introduce new algorithmic concepts that enable large-scale computation of EFMs. Distinguishing extreme rays from normal (composite) vectors is one critical aspect of the algorithm. We present a new recursive enumeration strategy with bit pattern trees for adjacent rays--the ancestors of extreme rays--that is roughly one order of magnitude faster than previous methods. Additionally, we introduce a rank updating method that is particularly well suited for parallel computation and a residue arithmetic method for matrix rank computations, which circumvents potential numerical instability problems. Multi-core architectures of modern CPUs can be exploited for further performance improvements. The methods are applied to a central metabolism network of Escherichia coli, resulting in approximately 26 Mio. EFMs. Within the top 2% modes considering biomass production, most of the gain in flux variability is achieved. In addition, we compute approximately 5 Mio. EFMs for the production of non-essential amino acids for a genome-scale metabolic network of Helicobacter pylori. Only large-scale EFM analysis reveals the >85% of modes that generate several amino acids simultaneously. AVAILABILITY An implementation in Java, with integration into MATLAB and support of various input formats, including SBML, is available at http://www.csb. ethz.ch in the tools section; sources are available from the authors upon request.
Neighborhood conflicts: the role of social categorization

Purpose – In a multicultural context, this study aims to investigate the effect of ingroup versus outgroup categorization and stereotypes on residents' emotional and behavioral reactions in neighbor-to-neighbor conflicts. Based on the literature on the “black sheep effect”, the authors predicted that residents would actually be more irritated by ingroup than outgroup antagonists. Secondly, they predicted that reactions to deviant behavior by an outgroup antagonist would be shaped by the valence of stereotypes about the respective groups. Design/methodology/approach – Residents with either a native-Dutch or a Turkish background (n=529) completed a questionnaire on outgroup stereotypes, and responded to a conflict situation in which the ethnicity of an antagonist was manipulated between subjects. Findings – Supporting the black sheep effect, results reveal that both native-Dutch and Turkish residents reported more negative emotions towards an ingroup than an outgroup antagonist. In addition, when confronting an outgroup antagonist, stereotype negativity was related to more negative emotions and intentions for destructive conflict behavior. Social implications – The current study demonstrates that residents may actually get irritated more easily by ingroup than outgroup antagonists. Reactions to outgroup antagonists are further moderated by stereotype valence; negative outgroup stereotypes may lead to less tolerance towards outgroup antagonists and higher chances for conflict escalation. Originality/value – This is the first paper in which evidence for the black sheep effect is obtained in a field study and simultaneously for majority and minority members. In addition, evidence is presented that emotions may mediate the influence of the antagonist's group membership on conflict behavior.
The Impact of Governmental Policies in Institutional Fields: The Case of Innovation in the Dutch Concrete Industry

The creation of markets for new products involves interplay between various field constituents. A major challenge in this process is to establish a sufficient level of legitimacy in order for a market to become accepted in the organization field. Yet, this process of market creation may be suppressed by established institutional arrangements that actively block the diffusion of innovations and constrain change. In this paper, we examine the roles of regulatory structures, professional associations and competitors in market suppression. We pay particular attention to the actions and circumstances preventing change in a mature sector of the economy, despite state policies directed at change. Active resistance from professional associations and corporate actors inhibited creation of a new market. We draw upon institutional theory to provide an account of the different communities of interest involved in an institutional field, exploring how they are developed and negotiated. We argue that the role of the government and the impact of its policies in market construction may be overemphasized and that the complexity of its interaction with organizational fields may be underestimated.
Male inbreeding status affects female fitness in a seed‐feeding beetle

Inbreeding generally reduces male mating activity such that inbred males are less successful in male–male competition. Inbred males can also have smaller accessory glands, transfer less sperm and produce sperm that are less motile, less viable or have a greater frequency of abnormalities, all of which can reduce the fertilization success and fitness of inbred males relative to outbred males. However, few studies have examined how male inbreeding status affects the fitness of females with whom they mate. In this study, we examine the effect of male inbreeding status (inbreeding coefficient f = 0.25 vs. f = 0) on the fecundity, adult longevity and the fate of eggs produced by outbred females in the seed‐feeding beetle, Callosobruchus maculatus. Females mated to inbred males were less likely to lay eggs. Of those that laid eggs, females mated to inbred males laid 6–12% fewer eggs. Females mated to inbred males lived on average 5.4% longer than did females mated to outbred males, but this effect disappeared when lifetime fecundity was used as a covariate in the analysis. There was no effect of male inbreeding status on the proportion of a female’s eggs that developed or hatched, and no evidence that inbred males produced smaller nuptial gifts. However, ejaculates of inbred males contained 17–33% fewer sperm, on average, than did ejaculates of outbred males. Our study demonstrates that mating with inbred males has significant direct consequences for the fitness of female C. maculatus, likely mediated by effects of inbreeding status on the number of sperm in male ejaculates. Direct effects of male inbreeding status on female fitness should be more widely considered in theoretical models and empirical studies of mate choice.
Midregional proadrenomedullin reflects cardiac dysfunction in haemodialysis patients with cardiovascular disease.

BACKGROUND Although adrenomedullin is an indicator of cardiac dysfunction in haemodialysis patients, the clinical significance of midregional proadrenomedullin has not been elucidated. Objectives. We evaluated whether midregional proadrenomedullin reflects cardiac dysfunction, systemic inflammation or blood volume in haemodialysis patients. METHODS Plasma midregional proadrenomedullin, C-reactive protein and delta body weight (indicating excessive blood volume), and two-dimensional as well as Doppler echocardiographic variables were measured just before haemodialysis in 70 patients with cardiovascular disease. RESULTS The median value of midregional proadrenomedullin was 1.93 nmol/l before haemodialysis, and these levels were significantly reduced following haemodialysis. Log [midregional proadrenomedullin] was positively correlated with left ventricular end-systolic volume index, diameter of inferior vena cava, C-reactive protein and delta body weight (r = 0.328, r = 0.421, r = 0.356, r = 0.364), and negatively with blood pressure, deceleration time of an early diastolic filling wave, pulmonary venous flow velocity ratio and left ventricular ejection fraction (r = -0.330, r = -0.324, r = -0.479, r = -0.373). Multivariate regression analysis revealed that pulmonary venous flow velocity ratio, diameter of inferior vena cava and C-reactive protein were independently related factors for midregional proadrenomedullin concentration. CONCLUSION Plasma midregional proadrenomedullin levels increase in association with cardiac dysfunction, systemic inflammatory status and systemic blood volume in haemodialysis patients with concomitant cardiovascular disease.
African and European voices: speaking 'in harmony' as contemporary authenticity

Hans Huyssen, a contemporary South African composer whose social consciousness is an essential facet of his work, stresses the importance of period performance practice as a rejuvenating and significant movement within Western art music. Regarding contemporary music as 'the period music of our time', it is his conviction that period performance practice and contemporary composition share the same goal, and moreover that a synthesis of their artistic ideals offers possibilities for responding specifically to the intricate challenges posed by the 'new' South African multiculturalism. Recent international debates on the nature of the Early Music Movement and Historically Informed Performance Practice (HIPP) have not yet entered into South African musicological scholarship. Yet Huyssen is firmly convinced that these need to become part both of current local musicology, and of the great diversity in South African art music's creative, reproductive and reception contexts. This article, in presenting some of the composer's views on the topic, attempts an appraisal of Huyssen's stance. It contextualises the relevance of the debate about performance practice for the crucial shifts in cultural consciousness currently taking place within South African art music composition. Of particular interest is its propensity for obscuring distinctions between the past and the present, and for accommodating the diversity in compositional styles that reflect an increasing multiculturalism within the local art-music scene.
Visual search, singleton capture, and the control of attentional set in ADHD

We report the data on effects on visual search of (1) preview displays and (2) singleton targets and distractors in IQ‐matched ADHD and control children. All children showed interference from singleton distractors even when targets never carried singleton values. This interference from singleton distractors increased under preview conditions, indicating that the children then had fewer resources available to control attention. There was also one selective deficit for ADHD children; they showed marked problems in responding to singleton targets following preview displays. This suggests that, in ADHD, there is either a selective delay or an impairment in switching attentional sets (from a negative set to the preview to a positive set to a singleton target). We discuss the implications for understanding both ADHD and the development of selective attention.
Area and family effects on the psychopathology of the Millennium Cohort Study children and their older siblings.

BACKGROUND To model and compare contextual (area and family) effects on the psychopathology of children nested in families nested in areas. METHOD Data from the first two sweeps of the UK's Millennium Cohort Study were used. The final study sample was 9,630 children clustered in 6,052 families clustered in 1,681 Lower-layer Super Output Areas. The mean age of the children at Sweep 2 was 4.96 (SD = 2.76) years. Contextual risk was measured at area level with the Index of Multiple Deprivation (Sweep 1), and at family level with the number of proximal (Sweep 2) and distal (Sweep 1) adverse life events experienced. Psychopathology was measured at Sweep 2 with the Strengths and Difficulties Questionnaire. RESULTS At baseline, both proximal and distal family risk and area risk predicted broad psychopathology, although the most parsimonious was the proximal family risk model, and both the family-level and the area-level variability were significant. The area risk/broad psychopathology association remained significant even when family risk was controlled, but not when family socioeconomic status was controlled. The full model added parenting and paternal and maternal psychopathology. When parental qualifications were excluded from the family-level contextual controls the effect of area risk remained significant on both externalizing and internalizing psychopathology. CONCLUSIONS The effect of area on child psychopathology operated via the socioeconomic characteristics of the child's family, not just the adverse characteristics of the neighbors. Multiple family risk predicted child psychopathology directly and independently, and not because it was associated with family socioeconomic status. Family socioeconomic status explained the association between area risk and broad psychopathology.
The gendered nature of role model status: an empirical study

Purpose – The purpose of this paper is to understand better the gendered nature of role model status within organizations. The paper aims to argue that women require organizational legitimacy to be perceived as a role model, whereas men rely primarily on the strength of social ties within their friendship networks.Design/methodology/approach – An empirical study of admissions department employees at a large eastern university within the USA was conducted. Using a social network approach, participants were asked to identify advice, friendship and role model relationships and provide information about awards and recognition received from the organization.Findings – The results showed that, in order to be perceived as a role model, females needed to give (but not ask for) advice, earn organizational rewards, hold leadership positions in the organization, and maintain strong ties with other employees. Males only had to have a number of friendship or advice ties to be seen as a role model.Research limitations/.
Teaching practicum supervisors' identity and student assessment on the practicum: An assorted mind-set?

Abstract The study examined the influence of teaching practicum supervisors' identity on student assessment during the practicum. Identity was based on supervisors' teaching experience and subject background. Using a confirmatory research design with qualitative and quantitative methods, data was drawn from 150 assessment forms on lessons observed by 15 supervisors' during practicum besides follow-up interviews. Findings show that there is no relationship between supervisors' identity and assessment of students' knowledge of subject content. However, a significant relationship is suggested between supervisors' identity and rating of students' teaching plans, communication, use of instructional materials, classroom management, and evaluation of the teaching and learning process. Emphasis during assessment was placed on context-dependent rather than contextindependent variables of the observed lessons. Context-dependent aspects are perceived differently by supervisors because they require students to reconstruct acquired knowledge to solve diverse teaching-related challenges. The assessment form completed by supervisors during lesson observation is a platform for discourse between the objective and subjective elements of assessment, whose outcome eventually determines students' teaching performance. The form elevates supervisors to final judges as they negotiate along the objective and subjective continuum. Although perceived as rigid, it ensures validity and reliability of the scores obtained.
MLP-based log spectral energy mapping for robust overlapping speech recognition

This paper investigates a multilayer perceptron (MLP) based acoustic feature mapping to extract robust features for automatic speech recognition (ASR) of overlapping speech. The MLP is trained to learn the mapping from log mel filter bank energies (MFBEs) extracted from the distant microphone recordings, including multiple overlapping speakers, to log MFBEs extracted from the clean speech signal. The outputs of the MLP are then used to generate mel filterbank cepstral coefficient (MFCC) acoustic features, that are subsequently used in acoustic model adaptation and system evaluation. The proposed approach is evaluated through extensive studies on the MONC corpus, which includes both non-overlapping single speaker and overlapping multi-speaker conditions. We demonstrate that by learning the mapping between log MFBEs extracted from noisy and clean signals the performance of ASR system can be significantly improved in overlapping multi-speaker condition compared a conventional delay-sum beamforming approach, while keeping the performance of the system on single non-overlapping speaker condition intact.
Investigating the link between gun possession and gun assault.

OBJECTIVES We investigated the possible relationship between being shot in an assault and possession of a gun at the time. METHODS We enrolled 677 case participants that had been shot in an assault and 684 population-based control participants within Philadelphia, PA, from 2003 to 2006. We adjusted odds ratios for confounding variables. RESULTS After adjustment, individuals in possession of a gun were 4.46 (P < .05) times more likely to be shot in an assault than those not in possession. Among gun assaults where the victim had at least some chance to resist, this adjusted odds ratio increased to 5.45 (P < .05). CONCLUSIONS On average, guns did not protect those who possessed them from being shot in an assault. Although successful defensive gun uses occur each year, the probability of success may be low for civilian gun users in urban areas. Such users should reconsider their possession of guns or, at least, understand that regular possession necessitates careful safety countermeasures.