Miracle-dz/UniFAR-FTUs huggingface dataset:
Interplay between Affect and Arousal in Recognition Memory

Background Emotional states linked to arousal and mood are known to affect the efficiency of cognitive performance. However, the extent to which memory processes may be affected by arousal, mood or their interaction is poorly understood. Methodology/Principal Findings Following a study phase of abstract shapes, we altered the emotional state of participants by means of exposure to music that varied in both mood and arousal dimensions, leading to four different emotional states: (i) positive mood-high arousal; (ii) positive mood-low arousal; (iii) negative mood-high arousal; (iv) negative mood-low arousal. Following the emotional induction, participants performed a memory recognition test. Critically, there was an interaction between mood and arousal on recognition performance. Memory was enhanced in the positive mood-high arousal and in the negative mood-low arousal states, relative to the other emotional conditions. Conclusions/Significance Neither mood nor arousal alone but their interaction appears most critical to understanding the emotional enhancement of memory.
Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7 monoclonal antibody, for treating inflammatory bowel diseases.

AIMS AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration were evaluated in a randomized, double-blind, placebo-controlled study. METHODS Healthy male subjects (n= 68) received a single dose of AMG 181 or placebo at 0.7, 2.1, 7, 21, 70 mg s.c. (or i.v.), 210 mg s.c. (or i.v.), 420 mg i.v. or placebo. Four ulcerative colitis (UC) subjects (n= 4, male : female 2:2) received 210 mg AMG 181 or placebo s.c. (3:1). AMG 181 concentration, anti-AMG 181-antibody (ADA), α4 β7 receptor occupancy (RO), target cell counts, serum C-reactive protein, fecal biomarkers and Mayo score were measured. Subjects were followed 3-9 months after dose. RESULTS Following s.c. dosing, AMG 181 was absorbed with a median tmax ranging between 2-10 days and a bioavailability between 82% and 99%. Cmax and AUC increased dose-proportionally and approximately dose-proportionally, respectively, within the 70-210 mg s.c. and 70-420 mg i.v. ranges. The linear β-phase t1/2 was 31 (range 20-48) days. Target-mediated disposition occurred at serum AMG 181 concentrations of less than 1 μg ml(-1) . The PD effect on α4 β7 RO showed an EC50 of 0.01 μg ml(-1) . Lymphocytes, eosinophils, CD4+ T cells and subset counts were unchanged. AMG 181-treated UC subjects were in remission with mucosal healing at weeks 6, 12 and/or 28. The placebo-treated UC subject experienced colitis flare at week 6. No ADA or AMG 181 treatment-related serious adverse events were observed. CONCLUSIONS AMG 181 has PK/PD, safety, and effect profiles suitable for further testing in subjects with inflammatory bowel diseases.
The Clustering of Faint Galaxies and the Evolution of XI (r)

The two-point angular correlation function, $\w$, is constructed from a catalog of 13,000 objects in 24 fields distributed over an area of 4 deg$^2$ and complete to a limit of $R = 23.5$. The amplitude and slope of our correlation function on arcminute scales are in broad agreement with recent CCD results in the literature and decreases with depth. No evidence is found for a flattening of the slope of the correlation function away from $\delta \sim 0.8$. Using the redshift distribution from the recent I-band selected Canada-France Redshift Survey, the observed $w(\theta)$ implies a value of the clustering length $r_0 = 1.86 \pm 0.43 \h$ Mpc ($q_0 = 0.5$) at $z = 0.48$. This is generally consistent with the possible rates of clustering evolution expected for optically selected galaxies. We finally discuss the implications of our results for the nature of the faint galaxy population.
Is Partisan Alignment Electorally Rewarding? Evidence from Village Council Elections in India

Do ruling parties positively discriminate in favour of their own constituencies in allocating public resources? If they do, do they gain electorally in engaging in such a practice? This paper tests whether partisan alignment exists in the allocation of funds for India's largest social protection programme, the National Rural Employment Guarantee Scheme (NREGS) in the state of West Bengal in India, and whether incumbent local governments (village councils) gain electorally in the practice of partisan alignment. Using a quasi-experimental research design, we find that the village council level ruling-party spends significantly more in its own party constituencies as compared to opponent constituencies. We also find strong evidence of electoral rewards in the practice of partisan alignment. However, we find that the results differ between the two main ruling political parties at the village council level in the state.
Relative biological effectiveness (RBE) of 30 MeV electrons at varying depths in tissue.

Abstract Using the stunting of vertebral growth of one-week-old inbred WHT/Ht mice as the biological test material and Fricke's ferrous sulphate method for dose measurements, the biological effectiveness of 30 MeV electrons relative to 250 kVp X rays has been found to be in the region of 0·82. No difference of statistical significance has been observed in the RBE of 30 MeV electrons given as single doses of 500 and 750 rads at per cent depth-dose levels varying from 100 to 10 in the case of the former and 100 to 15 in the case of the latter.
Anthropogenically driven environmental changes shift the ecological dynamics of hemorrhagic fever with renal syndrome

Zoonoses are increasingly recognized as an important burden on global public health in the 21st century. High-resolution, long-term field studies are critical for assessing both the baseline and future risk scenarios in a world of rapid changes. We have used a three-decade-long field study on hantavirus, a rodent-borne zoonotic pathogen distributed worldwide, coupled with epidemiological data from an endemic area of China, and show that the shift in the ecological dynamics of Hantaan virus was closely linked to environmental fluctuations at the human-wildlife interface. We reveal that environmental forcing, especially rainfall and resource availability, exert important cascading effects on intra-annual variability in the wildlife reservoir dynamics, leading to epidemics that shift between stable and chaotic regimes. Our models demonstrate that bimodal seasonal epidemics result from a powerful seasonality in transmission, generated from interlocking cycles of agricultural phenology and rodent behavior driven by the rainy seasons.
Pursuits: eye-based interaction with moving targets

Eye-based interaction has commonly been based on estimation of eye gaze direction, to locate objects for interaction. We introduce Pursuits, a novel and very different eye tracking method that instead is based on following the trajectory of eye movement and comparing this with trajectories of objects in the field of view. Because the eyes naturally follow the trajectory of moving objects of interest, our method is able to detect what the user is looking at, by matching eye movement and object movement. We illustrate Pursuits with three applications that demonstrate how the method facilitates natural interaction with moving targets.
Kinetic and Mechanistic Studies of a Cell Cycle Protein Phosphatase Cdc14*

The Cdc14 family of protein phosphatases is conserved within eukaryotes and antagonizes the action of cyclin-dependent kinases, thereby promoting mitotic exit and cytokinesis. We performed a detailed kinetic and mechanistic study of the Cdc14 phosphatases with both small molecule aryl phosphates and a physiological protein substrate hCdh1. We found that Cdc14 displays a strong preference for two-ringed aryl phosphates over smaller one-ringed or larger, multi-ringed substrates, a finding that may have important implications for inhibitor design. Results from both leaving group and pH dependence of the Cdc14-catalyzed reaction are consistent with a general acid-independent mechanism for substrates with leaving group pKa < 7 and a general acid-dependent mechanism for substrates with leaving group pKa > 7. The use of both low and high leaving group pKa substrates, in combination with steady-state and pre-steady-state kinetic techniques enabled the isolation and analysis of both the phosphoenzyme (E-P) formation and hydrolysis step. We established the requirement of general acid catalysis for E-P formation in reactions with high leaving group pKa substrates, and the presence of general base catalysis in E-P hydrolysis. Mutational study of invariant acidic residues in Cdc14 identified Asp253 as the general acid during E-P formation and the general base in E-P hydrolysis. We also identified several residues including Asp50, Asp129, Glu168, Glu171, and Asp177 in the Cdc14 active site cleft that are required for efficient dephosphorylation of hCdh1.
UvA-DARE ( Digital Academic Repository ) Boosting impulse control in addiction : Pharmacological neuroimaging studies

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A Quantitative Golgi Study of Dendritic Morphology in the Mice Striatal Medium Spiny Neurons

In this study we have provided a detailed quantitative morphological analysis of medium spiny neurons (MSNs) in the mice dorsal striatum and determined the consistency of values among three groups of animals obtained in different set of experiments. Dendritic trees of 162 Golgi Cox (FD Rapid GolgiStain Kit) impregnated MSNs from 15 adult C57BL/6 mice were 3-dimensionally reconstructed using Neurolucida software, and parameters of dendritic morphology have been compared among experimental groups. The parameters of length and branching pattern did not show statistically significant difference and were highly consistent among groups. The average neuronal soma surface was between 160 μm2 and 180 μm2, and the cells had 5–6 primary dendrites with close to 40 segments per neuron. Sholl analysis confirmed regular pattern of dendritic branching. The total length of dendrites was around 2100 μm with the average length of individual branching (intermediate) segment around 22 μm and for the terminal segment around 100 μm. Even though each experimental group underwent the same strictly defined protocol in tissue preparation and Golgi staining, we found inconsistency in dendritic volume and soma surface. These changes could be methodologically influenced during the Golgi procedure, although without affecting the dendritic length and tree complexity. Since the neuronal activity affects the dendritic thickness, it could not be excluded that observed volume inconsistency was related with functional states of neurons prior to animal sacrifice. Comprehensive analyses of tree complexity and dendritic length provided here could serve as an additional tool for understanding morphological variability in the most numerous neuronal population of the striatum. As reference values they could provide basic ground for comparisons with the results obtained in studies that use various models of genetically modified mice in explaining different pathological conditions that involve MSNs.
Tunable and Memorable Optical Devices with One-Dimensional Photonic-Crystal/Liquid-Crystal Hybrid Structures

© 2012 Wu and Lee, licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Tunable and Memorable Optical Devices with One-Dimensional Photonic-Crystal/Liquid-Crystal Hybrid Structures
Serum MicroRNAs as Potential Biomarkers for Early Diagnosis of Hepatitis C Virus-Related Hepatocellular Carcinoma in Egyptian Patients

Circulating microRNAs are deregulated in liver fibrosis and hepatocellular carcinoma (HCC) and are candidate biomarkers. This study investigated the potential of serum microRNAs; miR-19a, miR-296, miR-130a, miR-195, miR-192, miR-34a, and miR-146a as early diagnostic biomarkers for hepatitis C virus (HCV)-related HCC. As how these microRNAs change during liver fibrosis progression is not clear, we explored their serum levels during fibrosis progression in HCV-associated chronic liver disease (CLD) and if they could serve as non-invasive biomarkers for fibrosis progression to HCC. 112 Egyptian HCV-HCC patients, 125 non-malignant HCV-CLD patients, and 42 healthy controls were included. CLD patients were subdivided according to Metavir fibrosis-scoring. Serum microRNAs were measured by qRT-PCR custom array. Serum microRNAs were deregulated in HCC versus controls, and except miR-130a, they were differentially expressed between HCC and CLD or late fibrosis (F3-F4) subgroup. Serum microRNAs were not significantly different between individual fibrosis-stages or between F1-F2 (early/moderate fibrosis) and F3-F4. Only miR-19a was significantly downregulated from liver fibrosis (F1-F3) to cirrhosis (F4) to HCC. Individual microRNAs discriminated HCC from controls, and except miR-130a, they distinguished HCC from CLD or F3-F4 patients by receiver-operating-characteristic analysis. Multivariate logistic analysis revealed a panel of four microRNAs (miR-19a, miR-195, miR-192, and miR-146a) with high diagnostic accuracy for HCC (AUC = 0.946). The microRNA panel also discriminated HCC from controls (AUC = 0.949), CLD (AUC = 0.945), and F3-F4 (AUC = 0.955). Studied microRNAs were positively correlated in HCC group. miR-19a and miR-34a were correlated with portal vein thrombosis and HCC staging scores, respectively. In conclusion, studied microRNAs, but not miR-130a, could serve as potential early biomarkers for HCC in high-risk groups, with miR-19a as a biomarker for liver fibrosis progression to cirrhosis to HCC. We identified a panel of four serum microRNAs with high accuracy in HCC diagnosis. Additional studies are required to confirm this panel and test its prognostic significance.
Preoperative features of patients with exfoliation glaucoma and primary open-angle glaucoma. The AHEPA study.

PURPOSE To describe and compare the preoperative characteristics of Greek patients with exfoliation glaucoma (EXG) and primary open-angle glaucoma (POAG). METHODS We prospectively investigated the preoperative features of 100 consecutive patients undergoing filtration surgery for either EXG, or POAG. We compared 74 patients with EXG and 26 with POAG. RESULTS EXG patients were older (68.2 vs 62.4 years; p<0.05) and more often from the countryside (73%). Both glaucomas showed a preponderance for males, similar frequencies of positive family history and systemic disorders, with the exception of diabetes which was more common in POAG (19.2% vs 5.4%). The first IOP measurement, before treatment, was significantly higher in EXG (40.4 mm Hg) compared with POAG (33.9 mm Hg). Despite a shorter duration of medical therapy (25 vs 65 months) and more topical drugs EXG patients exhibited higher mean preoperative IOP (36 vs 27.8 mm Hg for POAG; p<0.05). EXG patients had significantly worse visual acuity than POAG (0.4 vs 0.6; p<0.05) and worse compliance to medical therapy (48%) compared to POAG (33%). CONCLUSION Significant differences in preoperative features distinguish EXG from POAG.
ActiveClean: Interactive Data Cleaning For Statistical Modeling

Analysts often clean dirty data iteratively--cleaning some data, executing the analysis, and then cleaning more data based on the results. We explore the iterative cleaning process in the context of statistical model training, which is an increasingly popular form of data analytics. We propose ActiveClean, which allows for progressive and iterative cleaning in statistical modeling problems while preserving convergence guarantees. ActiveClean supports an important class of models called convex loss models (e.g., linear regression and SVMs), and prioritizes cleaning those records likely to affect the results. We evaluate ActiveClean on five real-world datasets UCI Adult, UCI EEG, MNIST, IMDB, and Dollars For Docs with both real and synthetic errors. The results show that our proposed optimizations can improve model accuracy by up-to 2.5x for the same amount of data cleaned. Furthermore for a fixed cleaning budget and on all real dirty datasets, ActiveClean returns more accurate models than uniform sampling and Active Learning.
Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line

The present study investigated the photoprotective properties of the ethyl acetate fraction of Sargassum muticum (SME) against ultraviolet B (UVB)-induced skin damage and photoaging in a mouse model. HR-1 strain hairless male mice were divided into three groups: An untreated control group, a UVB-irradiated vehicle group and a UVB-irradiated SME group. The UVB-irradiated mice in the SME group were orally administered with SME (100 mg/kg body weight in 0.1 ml water per day) and then exposed to radiation at a dose of 60–120 mJ/cm2. Wrinkle formation and skin damage were evaluated by analysis of skin replicas, epidermal thickness and collagen fiber integrity in the dermal connective tissue. The mechanism underlying the action of SME was also investigated in the human HaCaT keratinocyte cell line following exposure of the cells to UVB at a dose of 30 mJ/cm2. The protein expression levels and activity of matrix metalloproteinase-1 (MMP-1), and the binding of activator protein-1 (AP-1) to the MMP-1 promoter were assessed in the HaCaT cells using western blot analysis, an MMP-1 fluorescent assay and a chromatin immune-precipitation assay, respectively. The results showed that the mean length and depth of the wrinkles in the UVB-exposed hairless mice were significantly improved by oral administration of SME, which also prevented the increase in epidermal thickness triggered by UVB irradiation. Furthermore, a marked increase in collagen bundle formation was observed in the UVB-treated mice with SME administration. SME pretreatment also significantly inhibited the UVB-induced upregulation in the expression and activity of MMP-1 in the cultured HaCaT keratinocytes, and the UVB-enhanced association of AP-1 with the MMP-1 promoter. These results suggested that SME may be useful as an anti-photoaging resource for the skin.
Morphine glucuronidation in premature neonates.

The glucuronidation of morphine was investigated in 10 premature neonates (postnatal age < 24 h at initiation of treatment) following 24 h of therapy (2 h loading infusion, followed by a constant rate infusion). Morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were measured in plasma obtained at 24 h in all babies. Plasma concentrations of M3G and M6G correlated significantly with morphine concentration (P < 0.01 in both cases), and with each other (P < 0.001), suggesting that the capacity for morphine glucuronidation in premature neonates is not saturated at the infusion rates used in this study. M3G/morphine and M6G/morphine plasma concentration ratios were independent of morphine infusion rates (P > 0.05) and morphine plasma concentrations (P > 0.05), providing further evidence of linear kinetics. However, M3G/morphine and M6G/morphine plasma concentration ratios increased significantly with increasing birth weight (P < 0.05 in both cases). This probably reflects increase in liver weight with increasing birth weight. Although morphine glucuronidation is deficient in premature neonates, significant concentrations of the respiratory stimulant M3G are achieved rapidly (20% of morphine plasma concentrations at 2 h). At this time, the respiratory depressant M6G could not be detected.
Self-Assessment: Review and Implications for Training

Abstract : Across the spectrum of self-assessment research, a topic of debate concerns the accuracy by which individuals can evaluate their own performance. While some research has found self-assessment to be an effective measure, the majority typically found it to be an under- or over-estimation of actual performance. Although the accuracy of self-assessment has seen skepticism, benefits have been well documented. The current review is the result of examination concerning self-assessment accuracy and utility. The literature was searched to evaluate the ability of trainees/job incumbents/students to accurately report their level of ability or performance. Upon examination of the self-assessment accuracy literature, problems arose concerning terminology and differential utilization of self-assessment. This review reports that self-assessment, as currently used, is generally inaccurate; but given appropriate consideration of the moderating variables and clarification of terminology, self-assessment accuracy could increase. The Army should utilize a continuum of self-assessment, considering domain and skill level as determinant factors. Self-grading could be useful for the introduction and training of new skills. Self-impression may be useful for assessing Soldiers' confidence, self-perception of personality or traits, and continuous performance appraisal. Implementation of the continuum has potential to improve training quality and skill retention throughout the Army.
Electromagnetic Considerations for Designing Double-Sided Power Modules

Double-sided power modules are especially attractive due to high thermal performances. Thanks to the stacking of two DBCs, very low stray inductances may be expected, especially because of the proximity of the two rear metallization. On the other hand, capacitive effects may be increased. In this paper, the complete electromagnetic behaviour of double sided power modules is studied, regarding both internal coupling, and unwanted EMC emissions. Some layout and active solutions are proposed to reduce common mode emissions.
Prevalence and factors associated with late HIV diagnosis

While highly active antiretroviral therapy has been successful in delaying progression into AIDS, late HIV diagnosis remains a major contributor to the mortality and morbidity of AIDS. An epidemiological study was conducted to evaluate the prevalence and factors of late diagnosis and the characteristics of those individuals with late diagnosis in Liuzhou city. Patients with late diagnosis were defined as either those who were diagnosed with AIDS at the time of HIV diagnosis or as those who developed AIDS no more than 1 year after HIV diagnosis. Of 899 participants, 72.6% had a late diagnosis. Common characteristics of those who experienced late diagnosis included older participants, those who were unexpectedly diagnosed while seeking other medical attention, participants who believed they could not acquire HIV from their regular heterosexual partners, those who never considered getting tested for HIV, and patients with unexplained weight loss, angular cheilitis, or prolonged fever prior to HIV diagnosis. On the other hand, those participants who were diagnosed via testing at compulsory rehabilitation centers and those whose annual household income was greater than 30,000 Yuan were less likely to be diagnosed late. These results suggested that late HIV diagnosis is common in Liuzhou city, and it is essential to promote appropriate strategies to detect HIV infections earlier. Strategies that require HIV/AIDS patients to notify their spouse/sexual‐partners about their HIV‐positive results within one month and start provider‐initiated HIV testing and counseling in medical facilities are beneficial to earlier HIV diagnosis. J. Med. Virol. 87:970–977, 2015. © 2015 Wiley Periodicals, Inc.