Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulation of Myostatin/Hepatocyte Growth Factor Balance by Different Hemodialysis Modalities

Background. In this study we investigated the relevance of myostatin and Hepatocyte Growth Factor (HGF) in patients undergoing hemodialysis HD and the influence of different HD modalities on their levels. Methods. We performed a prospective crossover study in which HD patients were randomized to undergo 3-month treatment periods with bicarbonate hemodialysis (BHD) followed by online hemodiafiltration (HDF). Clinical data, laboratory parameters, and myostatin and HGF serum levels were collected and compared. Results. Ten patients and six controls (C) were evaluated. In any experimental condition myostatin and HGF levels were higher in HD than in C. At enrollment and after BHD there were not significant correlations, whereas at the end of the HDF treatment period myostatin and HGF were inversely correlated (r −0.65, p < 0.05), myostatin serum levels inversely correlated with transferrin (r −0.73, p < 0.05), and HGF levels that resulted positively correlated with BMI (r 0.67, p < 0.05). Moving from BHD to HDF, clinical and laboratory parameters were unchanged, as well as serum HGF, whereas myostatin levels significantly decreased (6.3 ± 4.1 versus 4.3 ± 3.1 ng/ml, p < 0.05). Conclusions. Modulation of myostatin levels and myostatin/HGF balance by the use of different HD modalities might represent a novel approach to the prevention and treatment of HD-related muscle wasting syndrome.
Improved type specialization for dynamic scripting languages

Type feedback and type inference are two common methods used to optimize dynamic languages such as JavaScript. Each of these methods has its own strengths and weaknesses, and we propose that each can benefit from the other if combined in the right way. We explore the interdependency between these two methods and propose two novel ways to combine them in order to significantly increase their aggregate benefit and decrease their aggregate overhead. In our proposed strategy, an initial type inference pass is applied that can reduce type feedback overhead by enabling more intelligent placement of profiling hooks. This initial type inference pass is novel in the literature. After profiling, a final type inference pass uses the type information from profiling to generate efficient code. While this second pass is not novel, we significantly improve its effectiveness in a novel way by feeding the type inference pass information about the function signature, i.e., the types of the function's arguments for aspecific function invocation. Our results show significant speedups when using these low-overhead strategies, ranging from 1.2x to 4x over an implementation that does not perform type feedback or type inference based optimizations. Our experiments are carried out across a wide range of traditional benchmarks and realistic web applications. The results also show an average reduction of 23.5% in the size of the profiled data for these benchmarks.
Add-on bevacizumab can prevent early clinical deterioration and prolong survival in newly diagnosed partially resected glioblastoma patients with a poor performance status

Purpose The AVAglio trial established the beneficial effect of add-on bevacizumab (BEV) for the treatment of newly diagnosed glioblastomas (nd-GBMs) that led to the approval of BEV for the treatment of these patients in Japan. However, the rationality of using BEV as a first-line treatment for nd-GBMs remains controversial. The purpose of this study was to analyze the outcomes of a case series of nd-GBM patients. Patients and methods The outcomes of 69 nd-GBM patients treated after 2006 were retrospectively analyzed. Clinical and genetic analyses were performed, and estimates of progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan–Meier method. Since add-on BEV therapy was only used for partially resected GBMs (pr-GBMs) after its approval in 2013, the patients were subdivided into 3 treatment groups: Type I, partial removal with temozolomide (TMZ)/BEV and concurrent radiotherapy (CCRT); Type II, partial removal with TMZ and CCRT; and Type III, gross total removal with TMZ and CCRT. Results The PFS rate of Type I patients was significantly higher than that of Type II patients (P=0.014), but comparable to that of Type III patients. Differences in OS rates between Type I and Type II patients were less apparent (P=0.075), although the median OS of Type I patients was ~8 months higher than that of Type II patients (17.4 vs 9.8 months, respectively). The clinical deterioration rate during initial treatment was significantly (P=0.024) lower in Type I than in Type II patients (7.7% vs 47.4%, respectively). Differences in OS rates between Type I and Type II patients with a poor performance status (PS) were significant (P=0.017). Conclusion Our findings suggest that add-on BEV can prevent early clinical deterioration of pr-GBM patients and contribute to a prolonged survival, especially for those with a poor PS.
Neural activity during health messaging predicts reductions in smoking above and beyond self-report.

OBJECTIVE The current study tested whether neural activity in response to messages designed to help smokers quit could predict smoking reduction, above and beyond self-report. DESIGN Using neural activity in an a priori region of interest (a subregion of medial prefrontal cortex [MPFC]), in response to ads designed to help smokers quit smoking, we prospectively predicted reductions in smoking in a community sample of smokers (N = 28) who were attempting to quit smoking. Smoking was assessed via expired carbon monoxide (CO; a biological measure of recent smoking) at baseline and 1 month following exposure to professionally developed quitting ads. RESULTS A positive relationship was observed between activity in the MPFC region of interest and successful quitting (increased activity in MPFC was associated with a greater decrease in expired CO). The addition of neural activity to a model predicting changes in CO from self-reported intentions, self-efficacy, and ability to relate to the messages significantly improved model fit, doubling the variance explained (R²self-report = .15, R²self-report + neural activity = .35, R²change = .20). CONCLUSION Neural activity is a useful complement to existing self-report measures. In this investigation, we extend prior work predicting behavior change based on neural activity in response to persuasive media to an important health domain and discuss potential psychological interpretations of the brain-behavior link. Our results support a novel use of neuroimaging technology for understanding the psychology of behavior change and facilitating health promotion.
Repeat endoscopic ultrasound-guided fine needle aspiration for solid pancreatic lesions at a tertiary referral center will alter the initial inconclusive result.

BACKGROUND & AIMS Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is indispensable for the diagnosis of solid pancreatic lesions (SPLs). However, initial attempt of EUS-FNA can be inconclusive. We retrospectively evaluated the ability of repeat EUS-FNA at a tertiary referral hospital to obtain a conclusive cytological diagnosis after the initial inconclusive EUS-FNA results at referring facilities. METHODS We identified patients who had undergone EUS-FNA for SPLs and with inconclusive cytological diagnosis at referring facilities. The diagnostic ability of EUS-FNA was defined as the percentage of cases with conclusive cytological diagnoses out of the total included cases in which initial results had been inconclusive. As a secondary outcome, we conducted sub-group analysis to reveal factors which might have assisted conclusive results at the University of Texas MD Anderson Cancer Center (MDA). RESULTS We found 913 patients who underwent EUS-FNA for SPLs between 2005 and 2011. Among them, we recruited 84 patients who met the above criteria. Repeat EUS-FNA had ability to clarify the diagnosis in 82.1 % (69/84). No statistical differences were observed in tumor size (n = 50, 29.8 versus 29.4 mm, P-value = 0.84) and the number of needles passes (n = 40, 4.0 versus 3.4, P-value = 0.1) between outside MDA and MDA. Rapid on-site evaluation was present in less than half of cases outside MDA (n = 33, 42.4 versus 100%, P-value = 0.0001). MDA endosonographers had more years of experience compared to outside MDA (n = 50, 12.9 versus 10 years, P-value = 0.015). CONCLUSIONS A repeat EUS-FNA for SPLs with initial inconclusive diagnosis at a tertiary referral center establishes a diagnosis in the majority of patients.
The relationship between erectile dysfunction and open urethroplasty: a systematic review and meta-analysis.

INTRODUCTION Various urethroplasty techniques have been used to treat urethral stricture. Whether the patient erectile function is affected by this open surgery is still controversial. AIM The aim of this study is to determine the relationship between erectile function and open urethroplasty. METHODS A systematic review of the literature was performed using Medline, Embase, the Web of Science, and the Cochrane Library databases through October 2012 to identify articles published in any language that examined the effect of open urethroplasty on the risk of erectile dysfunction (ED). This meta-analysis was conducted according to the guidelines for the meta-analysis of observational studies in epidemiology. MAIN OUTCOME MEASURES The incidence of ED after urethroplasty. RESULTS This meta-analysis consisted of 23 cohort studies, which included 1,729 cases. No significant difference was noticed in patients with anterior urethral stricture before or after intervention (odds ratio [OR] = 0.86; 95% confidence interval [CI]: 0.52-1.40; P = 0.53). While statistical difference in the incidence of ED was revealed in patients before and after intervention for a posterior urethral (OR = 2.51; 95% CI: 1.82-3.45; P < 0.001), further comparisons demonstrated that most anterior urethroplasties did not have an obvious effect on patient erectile function. However, it seems that the incidence of ED was higher in the bulbar anastomosis group than in the oral graft urethroplasty group (OR = 0.32 95% CI: 0.11-0.93; P = 0.04). For the posterior urethroplasty, previous operative history did not show a strong relationship with ED. No statistically significant difference in the risk of ED was demonstrated comparing the posterior urethral reconstructive techniques included in this analysis. CONCLUSION The adverse effect of urethroplasty itself on erectile function is limited, as more patients recover erectile function after urethral reconstruction. For anterior urethroplasty, bulbar anastomosis might cause a slightly higher incidence of ED than other operations. For posterior urethroplasty, trauma might be the main cause of ED.
Increased Risk of Dementia Among Sleep-Related Movement Disorders

AbstractSleep-related movement disorders (SRMD) are sleep disorders. As poor sleep quality is associated with cognitive impairment, we hypothesized that SRMD patients were exposed to a great risk for developing dementia.The present study was aimed to retrospectively examine the association of SRMD and dementia risk.A retrospective longitudinal study was conducted using the data obtained from the Longitudinal Health Insurance Database (LHID) in Taiwan. The study cohort enrolled 604 patients with SRMD who were initially diagnosed and 2416 patients who were randomly selected and age/gender matched with the study group. SRMD, dementia, and other confounding factors were defined according to International Classification of Diseases Clinical Modification Codes. Cox proportional-hazards regressions were employed to examine adjusted hazard ratios (HR) after adjusting with confounding factors.Our data revealed that patients with SRMD had a 3.952 times (95% CI = 1.124–4.767) higher risk to develop all-cause dementia compared with individuals without SRMD. The results showed that SRMD patients aged 45 to 64 exhibited highest risk of developing all-cause dementia (HR: 5.320, 95% CI = 1.770–5.991), followed by patients age ≥65 (HR: 4.123, 95% CI = 2.066–6.972) and <45 (HR: 3.170, 95% CI = 1.050–4.128), respectively. Females with SRMD were at greater risk to develop all-cause dementia (HR: 4.372, 95% CI = 1.175–5.624). The impact of SRMD on dementia risk was progressively increased by various follow-up time intervals (<1 year, 1–2 years, and ≥2 years). The results suggest that SRMD is linked to an increased risk for dementia with gender-dependent and time-dependent characteristics.
MicroRNA-300 inhibited glioblastoma progression through ROCK1

Glioblastoma is a common type of brain aggressive tumors and has a poor prognosis. MicroRNAs (miRNAs) are a class of small, endogenous and non-coding RNAs that play crucial roles in cell proliferation, survival and invasion. Deregulated expression of miR-300 has been studied in a lot of cancers. However, the role of miR-300 in glioblastoma is still unknown. In this study, we demonstrated that miR-300 expression was downregulated in glioblastoma tissues compared with the normal tissues. Lower expression level of miR-300 was observed in thirty cases (75 %, 30/40) of glioblastoma samples compared with the normal samples. Moreover, the overall survival of glioblastoma patients with lower miR-300 expression level was shorter than those with higher miR-300 expression level. In addition, miR-300 expression was also downregulated in glioblastoma cell lines. Overexpression of miR-300 inhibited cell proliferation, cell cycle and invasion in glioblastoma cell line U87 and U251. Moreover, we identified ROCK1 as a direct target of miR-300 in U87 and U251 cells. Overexpression of ROCK1 partially rescued the miR-300-mediated cell growth. ROCK1 expression levels in glioblastoma tissues were higher than that in normal tissues. ROCK1 expression levels were higher in thirty-one cases of glioblastoma samples than their normal samples. Furthermore, the expression level ROCK1 was inversely correlated with the expression level of miR-300. Importantly, overexpression of miR-300 suppressed glioblastoma progression in an established xenograft model. In conclusion, we revealed that miR-300 might act as a tumor suppressor gene through inhibiting ROCK1 in glioblastoma.
Differential Myocyte Responses in Patients with Cardiac Transthyretin Amyloidosis and Light-Chain Amyloidosis: A Cardiac MR Imaging Study.

PURPOSE To investigate cardiac magnetic resonance (MR) imaging measurements of extracellular volume (ECV) and total cell volume in immunoglobulin light-chain amyloidosis (AL) and transthyretin amyloidosis (ATTR) in order to evaluate the amyloid and myocyte volumes. MATERIALS AND METHODS All ethics were approved, and participants provided written informed consent. Of the 257 subjects who were recruited, 92 had AL (mean age, 62 years ± 10), 44 had mutant ATTR (mean age, 68 years ± 10), and 66 had wild-type ATTR (mean age, 75 years ± 7). In addition, eight healthy subjects with ATTR mutations (mean age, 47 years ± 6) and 47 healthy volunteers (mean age, 45 years ± 15) participated. All participants underwent equilibrium contrast material-enhanced cardiac MR imaging. ECV and total cell volume were measured in the heart. T test, χ(2), and one-way analysis of variance with posthoc Bonferroni correction were used. RESULTS Both the left ventricular indexed mass and ECV were elevated in patients with amyloidosis. For left ventricular indexed mass, mean AL was 107 g/m(2) ± 30; mean mutant ATTR was 137 g/m(2) ± 29; and mean wild-type ATTR was 133 g/m(2) ± 27 versus 65 g/m(2) ± 15 in healthy subjects (P < .0001 for all measures). For ECV, mean AL was 0.54 ± 0.07, mean mutant ATTR was 0.60 ± 0.07, and mean wild-type ATTR was 0.57 ± 0.06 versus 0.27 ± 0.03 in healthy subjects (P < .0001 for all measures). Patients with ATTR had a higher total cell volume than did healthy subjects (mean, 53 mL/m(2) ± 12 vs 45 mL/m(2) ± 11; P = . 001), but in patients with AL, total cell volume was normal (mean, 47 mL/m(2) ± 17 vs 45 mL/m(2) ± 11; P > . 99). The result is that, in patients with AL, all of the increase in left ventricular indexed mass is extracellular volume, whereas in patients with ATTR, the increase is extracellular, with an additional 18% increase in the intracellular space. CONCLUSION Quantification of ECV measures cardiac amyloid deposition in both types of amyloidosis and shows that amyloid deposition is more extensive in patients with ATTR than in those with AL; however, ATTR is associated with higher cell volume, which suggests concomitant cell hypertrophy.
Determining crustal structure beneath seismic stations overlying a low‐velocity sedimentary layer using receiver functions

The receiver function (RF) technique has been widely applied to investigate crustal and mantle layered structures using P‐to‐S converted (Ps) phases from velocity discontinuities. However, the presence of low‐velocity (relative to that of the bedrock) sediments can give rise to strong reverberations in the resulting RFs, frequently masking the Ps phases from crustal and mantle boundaries. Such reverberations are caused by P‐to‐S conversions and their multiples associated with the strong impedance contrast across the bottom of the low‐velocity sedimentary layer. Here we propose and test an approach to effectively remove the near‐surface reverberations and decipher the Ps phases associated with the Moho discontinuity. Autocorrelation is first applied on the observed RFs to determine the strength and two‐way traveltime of the reverberations, which are then used to construct a resonance removal filter in the frequency domain to remove or significantly reduce the reverberations. The filtered RFs are time corrected to eliminate the delay effects of the sedimentary layer and applied to estimate the subsediment crustal thickness and VP/VSusing a H‐k stacking procedure. The resulting subsediment crustal parameters (thickness and VP/VS) are subsequently used to determine the thickness and VP/VS of the sedimentary layer, using a revised version of the H‐k stacking procedure. Testing using both synthetic and real data suggests that this computationally inexpensive technique is efficient in resolving subsediment crustal properties beneath stations sitting on a low‐velocity sedimentary layer and can also satisfactorily determine the thickness and VP/VS of the sedimentary layer.
Language, Semantics, and Methods for Cryptographic Protocols

In this report we present a process language for security protocols together with an operational semantics and an alternative semantics in terms of sets of events. The denotation of process is a set of events, and as each event specifies a set of pre- and postconditions, this denotation can be viewed as a Petri net. This Petri-net semantics has a strong relation to both Paulson's inductive set of rules [Pau98] and strand spaces [THG98c]. By means of an example we illustrate how the Petri-net semantics can be used to prove properties such as secrecy and authentication.
EVALUATION AND GUIDELINES FOR DRAINABLE BASES

Base materials are normally selected to achieve maximum density, and to possess enough stiffness and strength to carry the traffic loads. The poor drainability of these materials has been of concern. This report describes the characterization of base materials being commonly used throughout the State of Texas. This includes the characterization of stiffness and strength based on the resilient modulus and the static strength of compacted specimens. The drainability is evaluated based on the permeability coefficient and the water retention capacity. The water retention test was found to be easier to perform and it is believed to be more directly related to the drainability of the compacted base than the permeability test. Alternative materials evaluated consisted of open-graded bases and cement-stabilized gravel. The results of the present study indicate that cement stabilized gravel is the best alternative to achieve high stiffness and strength and at the same time minimize water retention capacity of the compacted base. Guidelines for design and construction of base layers are proposed based on properties of cement-stabilized gravel.
Mode I Interlaminar Fracture of Composite Laminates Incorporating with Ultrathin Fibrous Sheets

Attempts have been made to investigate the effect of ultrathin fibrous sheets (UFSs) arranged on the ply interface on mode I interlaminar fracture of a glass/epoxy composite laminate. The UFSs were obtained by electrospinning of epoxy 609 polymer solution and then incorporated into the middle interface of the laminate with various thicknesses. Mode I interlaminar fracture behaviors of the resulting laminates were characterized using double cantilever beam (DCB) specimens. Scanning electron microscope (SEM) was applied to analyze the fracture characteristics of the tested specimens. Results have shown that the UFS with a reasonable thickness would have no effect on the mode I delamination resistance of the laminate. To further investigate the effect of the sheets on the fracture toughness, some UFSs with thinner thickness were inserted into different interfaces of the laminate. Testing data have also shown that no significant effect on the mode I delamination resistance was recognized, although a summation of the sheets was thick. Fractured specimens analysis indicated no obvious delamination was observed when the incorporated sheet was thin.
Involvement of N‐acyl‐l‐homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens

Several bacterial species possess the ability to differentiate into highly motile swarmer cells capable of rapid surface colonization. In Serratia liquefaciens, we demonstrate that initiation of swarmer‐cell differentiation involves diffusible signal molecules that are released into the growth medium. Using high‐performance liquid chromatography (HPLC), high resolution mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, we identified N‐butanoyl‐l‐homoserine lactone (BHL) and N‐hexanoyl‐l‐homoserine lactone (HHL) in cell‐free Serratia culture supernatants. BHL and HHL are present in a ratio of approximately 10:1 and their structures were unequivocally confirmed by chemical synthesis. The swrlswarmer initiation) gene, the predicted translation product of which exhibits substantial homology to the Luxl family of putative Nacyl homoserine lactone (AHL) synthases is responsible for directing synthesis of both BHL and HHL. In an swrl mutant, swarming motility is abolished but can be restored by the addition of an exogenous AHL. These results add swarming motility to the rapidly expanding list of phenotypes known to be controlled through quorum sensing.
An Overlapping Schwarz Method for Spectral Element Solution of the Incompressible Navier-Stokes Equations

Efficient solution of the Navier? Stokes equations in complex domains is dependent upon the availability of fast solvers for sparse linear systems. For unsteady incompressible flows, the pressure operator is the leading contributor to stiffness, as the characteristic propagation speed is infinite. In the context of operator splitting formulations, it is the pressure solve which is the most computationally challenging, despite its elliptic origins. We examine several preconditioners for the consistent L2Poisson operator arising in the PN? PN? 2spectral element formulation of the incompressible Navier? Stokes equations. We develop a finite element-based additive Schwarz preconditioner using overlapping subdomains plus a coarse grid projection operator which is applied directly to the pressure on the interior Gauss points. For large two-dimensional problems this approach can yield as much as a fivefold reduction in simulation time over previously employed methods based upon deflation.