Miracle-dz/UniFAR-FTUs huggingface dataset:
Using automated semantic tagging in Critical Discourse Analysis: A case study on Scottish independence from a Scottish nationalist perspective

To date, studies of social attitudes towards Scottish independence tend to have been of the structured survey or interview variety. This study seeks to support and build upon the findings of recent social attitude surveys on Scottish independence using what is, as far as the author is aware, a novel methodology. This involves combining the corpus linguistic technique of automated semantic tagging with a discourse-historical Critical Discourse Analysis (CDA) framework.Applying this to a three-million-word corpus built from a pro-independence internet discussion forum, the analysis shows, firstly, a view that independence will strengthen, consolidate or transform Scottish identity in a positive way and, secondly, a distinct lack of strategies that seek to dismantle British identity or refer to historical disputes. Thus, an evaluation of this methodology suggests that it successfully manages to produce findings that support previous research, challenge existing stereotypes, and allow new insight into Scottish nationalist ideology.
Doppler cooling of calcium ions using a dipole-forbidden transition

Doppler cooling of calcium ions has been experimentally demonstrated using the S1/2→D5/2 dipole-forbidden transition. Scattering forces and fluorescence levels a factor of 5 smaller than for the usual Doppler cooling on the dipole-allowed S1/2→P1/2 transition have been achieved. Since the light scattered from the ions can be monitored at (violet) wavelengths that are very different from the excitation wavelengths, single ions can be detected with an essentially zero background level. This, as well as other features of the cooling scheme, can be extremely valuable for ion-trap-based quantum-information processing.
PBDE Concentrations in Women’s Serum and Fecundability

Background Exposure to polybrominated diphenyl ether (PBDE) flame retardants is widespread, with 97% of Americans having detectable levels. Although PBDEs have been associated with reproductive and hormonal effects in animals, no human studies have examined their association with fertility. Objectives This study was designed to determine whether maternal concentrations of PBDEs in serum collected during pregnancy are associated with time to pregnancy and menstrual cycle characteristics. Methods Pregnant women (n = 223) living in a low-income, predominantly Mexican-immigrant community in California were interviewed to determine how many months they took to become pregnant. Blood samples were collected and analyzed for PBDEs. PBDE concentrations were lipid adjusted and log10 transformed. Analyses were limited to PBDE congeners detected in > 75% of the population (BDEs 47, 99, 100, 153). Cox proportional hazards models modified for discrete time were used to obtain fecundability odds ratios (fORs) for the association of PBDEs and time to pregnancy. Results We detected all four congeners in > 97% of women. Increasing levels of BDEs 47, 99, 100, 153 and the sum of these four congeners were all associated with longer time to pregnancy. We observed significantly reduced fORs for BDE-100 [adjusted fOR = 0.6; 95% confidence interval (CI), 0.4–0.9], BDE-153 (adjusted fOR = 0.5; 95% CI, 0.3–0.8), and the sum of the four congeners (adjusted fOR = 0.7; 95% CI, 0.5–1.0). PBDEs were not associated with menstrual cycle characteristics. Conclusions We found significant decreases in fecundability associated with PBDE exposure in women. Future studies are needed to replicate and confirm this finding.
Introducing strong structuration theory for informing qualitative case studies in organization, management and accounting research

Purpose – The aim of this paper is to present a reinforced version of structuration theory, known as strong structuration theory, set out in Stones as a disciplined approach to qualitative case study research in the organization, management and accounting fields. This framework challenges the belief held by certain critics that structuration theory cannot be used in substantive empirical research but is only a sensitising device or analytical tool.Design/methodology/approach – A conceptual discussion is the approach of the paper.Findings – The key concepts of strong structuration theory are outlined and then put in the context first of two attempts to apply the framework to empirical research and second of two recent papers which address theoretically informed qualitative research and the use of structuration theory in IT studies.Research limitations/implications – There are some limitations of this paper. The framework offered was not used to set the original research questions in the two case studies em.
Dynamic Voltage and Frequency Scaling for Long-Term and Fail-Safe Operation

This paper presents a dynamic voltage and frequency scaling methodology for long-term operation, using fault-tolerance to prevent failures. The DVFS methodology allows a dual-mode operation, targeting high performance or low-power operation modes, and using an on-line circuit monitoring with aging-aware fault-tolerance to prevent errors during a long-term operation. Fail-safe operation is achieved by using a cooperative work of global and local predictive fault detection sensors, sensitive to PVT and Aging (namely, Bias Temperature Instability effects), and using an additional fault-tolerance margin to improve error avoidance. High-level (Verilog) and Spice simulations for a 65nm CMOS technology demonstrate the results for the dynamic voltage and frequency scaling strategy, showing the fast switching between different operation modes (high performance or lowpower) and without errors. Keywords—component; formatting; style; styling; insert (key
Drugs that Target Specificity Proteins Downregulate Epidermal Growth Factor Receptor in Bladder Cancer Cells

The epidermal growth factor receptor (EGFR) is an important chemotherapeutic target for tyrosine kinase inhibitors and antibodies that block the extracellular domain of EGFR. Betulinic acid (BA) and curcumin inhibited bladder cancer cell growth and downregulated specificity protein (Sp) transcription factors, and this was accompanied by decreased expression of EGFR mRNA and protein levels. EGFR, a putative Sp-regulated gene, was also decreased in cells transfected with a cocktail (iSp) containing small inhibitory RNAs for Sp1, Sp3, and Sp4, and RNA interference with individual Sp knockdown indicated that EGFR expression was primarily regulated by Sp1 and Sp3. BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death. The results show that EGFR is an Sp-regulated gene in bladder cancer, and drugs such as BA and curcumin that repress Sp proteins also ablate EGFR expression. Thus, compounds such as curcumin and BA that downregulate Sp transcription factors represent a novel class of anticancer drugs that target EGFR in bladder cancer cells and tumors by inhibiting receptor expression. Mol Cancer Res; 8(5); 739–50. ©2010 AACR.
Tbx5 and Bmp Signaling Are Essential for Proepicardium Specification in Zebrafish

Rationale: The proepicardial organ (PE) contributes to the cellular diversity of the developing heart by giving rise to the epicardium as well as vascular smooth muscle cells and fibroblasts. Despite the importance of these cells in cardiac development, function and regeneration, the signals required for the specification of the PE remain largely unexplored. Objective: We aim to identify the signaling molecules and transcription factors that regulate PE specification. Methods and Results: Here, we present the first genetic evidence that bone morphogenetic protein (Bmp) signaling in conjunction with the T-box transcription factor Tbx5a is essential for PE specification in zebrafish. Specifically, Bmp4 from the cardiac region, but not the liver bud, acting through the type I BMP receptor Acvr1l, is required for PE specification. By overexpressing a dominant-negative form of a Bmp receptor at various embryonic stages, we determined when Bmp signaling was required for PE specification. We also found that overexpression of bmp2b right before PE specification led to the ectopic expression of PE specific markers including tbx18. Furthermore, using loss-of-function approaches, we discovered a previously unappreciated PE specification role for Tbx5a at early somite stages; this role occurs earlier than, and appears to be independent from, the requirement for Bmp signaling in this process. Conclusion: Altogether, these data lead us to propose that Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate PE development.
Incentives: The effects on the reading motivation of fourth‐grade students

Abstract The purpose of this study was to determine the effects of various incentives on the reading motivation of fourth‐grade students. The students involved in the study attended an elementary school in a mid‐size town in the South. Results were based on the participation of 28 students in the control group who received no incentives, 27 students in the treatment group who received books as incentives, and 36 students in the treatment group who received non‐reading related rewards as incentives. Each student's level of reading motivation was measured at the beginning and end of the study using the Reading Survey portion of the Motivation to Read Profile (Gambrell, Palmer, Codling, & Mazzoni, 1996), which was completed by each student, and the Parent Survey, which was completed by the guardian of each student participating in the study. Book logs were also used in the study to measure the students’ motivation to read based on the number of books read. The findings of the study indicated that there were no significant differences in reading motivation between students who received incentives and those who did not as measured by the Motivation to Read Profile and the numbers of books read.
The practitioner‐researcher divide in Industrial, Work and Organizational (IWO) psychology: Where are we now, and where do we go from here?

There is current concern that the researcher, or academic, and the practitioner wings of our discipline are moving further apart. This divergence is likely to result in irrelevant theory and in untheorized and invalid practice. Such outcomes will damage our reputation and ultimately result in our fragmentation. We present a simple 2 × 2 model along the dimensions of relevance and rigour, with the four cells occupied by Popularist, Pragmatic, Pedantic, and Puerile Science, respectively. We argue that there has been a drift away from Pragmatic Science, high in both relevance and rigour, towards Pedantic and Popularist Science, and through them to Puerile Science. We support this argument by longitudinal analyses of the authorship of academic journal articles and then explain this drift in terms of our stakeholders. Powerful academics are the most immediate stakeholders for researchers, and they exercise their power in such a way as to increase the drift towards Pedantic Science. Organizational clients are the most powerful stakeholders for practitioners, and in their effort to address their urgent issues, they push practitioners towards Popularist Science. In the light of this analysis, we argue that we need to engage in political activity in order to reduce or redirect the influence of the key stakeholders. This can be done either directly, through our relationship with them, or indirectly, through others who influence them. Only by political action can the centrifugal forces away from Pragmatic Science be countered and a centripetal direction be established. Finally, we explore the implications of our analysis for the future development of members of our own profession.
White matter lesions and cerebral atrophy on MR images in patients with and without AIDS dementia complex.

OBJECTIVE The objective of this study was threefold: to determine if the frequency of deep white matter changes and cerebral atrophy seen on MR images is significantly different between patients with and without AIDS dementia complex, to determine if certain patterns of white matter changes are more closely associated with AIDS dementia complex, and to determine if focal lesions within the white matter of the splenium are more common in AIDS dementia complex. MATERIALS AND METHODS Forty-five patients with AIDS were clinically examined for AIDS dementia complex. MR images from these patients were retrospectively reviewed without knowledge of the clinical results. The presence or absence of white matter abnormalities and cerebral atrophy was evaluated by using graded scales and correlated with the presence or absence of AIDS dementia complex. RESULTS Ten patients met the criteria for AIDS dementia complex. Eight of 25 patients in whom MR images showed abnormal signal intensity in deep white matter had dementia compared with two of 20 in whom MR showed no changes in deep white matter. The presence of these deep white matter abnormalities was not significantly different between groups with and without dementia (p = .08), although higher grades of deep white matter abnormality were more likely to be associated with AIDS dementia complex. Nine of 19 patients in whom MR images showed atrophy had dementia compared with one of 26 in whom MR showed no atrophy. Atrophy was significantly associated with AIDS dementia complex (p = .001). Eight of 15 patients in whom MR images showed abnormal signal intensity within the white matter of the splenium had dementia compared with two of 30 in whom MR showed normal signal intensity in this area. The degree of abnormality in the splenium was weakly associated with AIDS dementia complex (Kendall's tau = .471, p = .001). CONCLUSION MR findings of cerebral atrophy and abnormal signal intensity in the splenium are associated with AIDS dementia complex. The presence of generalized deep white matter abnormalities does not differ significantly between patients with and without dementia, although more severe grades of white matter abnormality are more likely to be seen in patients with AIDS dementia complex.
Diagnostic Yield and Safety of Cryoprobe Transbronchial Lung Biopsy in Diffuse Parenchymal Lung Diseases: Systematic Review and Meta-Analysis

BACKGROUND: Transbronchial lung biopsy with flexible forceps is the most commonly used technique in diagnosis of diseases diffusely involving the lung parenchyma. Recently, transbronchial lung biopsy using the flexible cryoprobe (cryo-transbronchial lung biopsy) has also been reported. Herein, we perform a systematic review and meta-analysis describing the efficacy and safety of cryo-transbronchial lung biopsy. METHODS: The PubMed and EMBASE databases were searched for studies reporting the outcomes of cryo-transbronchial lung biopsy in subjects with diffuse parenchymal lung involvement. The quality of individual studies was assessed using the QualSyst tool. The pooled diagnostic yield of cryo-transbronchial lung biopsy was calculated using proportion meta-analysis (random effects model). Heterogeneity was evaluated using the I2 test and Cochran Q test. Publication bias was determined using both statistical and graphical methods. RESULTS: Our search yielded 14 studies (1,183 subjects). The pooled diagnostic yield of cryo-transbronchial lung biopsy was 76.9% (95% CI 67.2–85.3) if only definitive diagnoses were considered and 85.9% (95% CI 78.2–92.2) if both definitive and probable diagnoses were considered. Four studies (321 subjects) the performance of flexible forceps biopsy and cryo-transbronchial lung biopsy. The diagnostic yield of cryo-transbronchial lung biopsy (86.3, 95% CI 80.2–90.8) was significantly higher than that of flexible forceps biopsy (56.5%, 95% CI 27.5–83.2) with an odds ratio of 6.7 (95% CI 3.6–12.4) and a number needed to treat of 4. Lung tissue was obtained in 98% of all samples with cryo-transbronchial lung biopsy and was free of compression artifacts. The size of samples obtained with cryo-transbronchial lung biopsy was significantly bigger compared with flexible forceps biopsy (20.4 vs 4.3 mm2, P = .005). The complications of cryo-transbronchial lung biopsy included pneumothorax (6.8%), severe bleeding (0.3%), and death (0.1%). Clinical and statistical heterogeneity was present, and there was evidence of publication bias. CONCLUSIONS: Cryo-transbronchial lung biopsy is a relatively safe procedure with good diagnostic yield in diseases diffusely involving the lung parenchyma.
Guiding real-world SAT solving with dynamic hypergraph separator decomposition

The general solution of satisfiability problems is NP-complete. Although state-of-the-art SAT solvers can efficiently obtain the solutions of many real-world instances, there are still a large number of real-world SAT families which cannot be solved in reasonable time. Much effort has been spent to take advantage of the internal structure of SAT instances. Existing decomposition techniques are based on preprocessing the static structure of the original problem. We present a dynamic decomposition method based on hypergraph separators. Integrating the separator decomposition into the variable ordering of a modern SAT solver leads to speedups on large real-world satisfiability problems. Compared with a static decomposition based variable ordering, such as Dtree (Huang and Darwiche, 2003), our approach does not need time to construct the full tree decomposition, which sometimes needs more time than the solving process itself. Our primary focus is to achieve speedups on large real-world satisfiability problems. Our results show that the new solver often outperforms both regular zChaff and zChaff integrated with Dtree decomposition. The dynamic separator decomposition shows promise in that it significantly decreases the number of decisions for some real-world problems.
Process, Perception and Power: Notes from ‘Participatory’ Research in a Zimbabwean Resettlement Area

The increased popularity of ‘participatory’ methods in research, development projects, and rural extension in developing countries, has not consistently been accompanied by a critical evaluation of the quality and reliability of knowledge created and extracted in the process. In this article, the author employs her own research using Participatory Rural Appraisal (PRA) in a Zimbabwean Resettlement Area, to examine how knowledge is created through this type of research act, and how later research may be used to turn back and ‘make sense’ of PRA data. The article explores how power relations among participants are both revealed and concealed in PRA, focusing specifically on the implications for gendered perspectives. The paper also highlights the dynamic, contested and often contradictory nature of ‘local knowledge’ itself. Apparently transparent chunks of ‘local reality’ gleaned through PRA can turn out to be part of complex webs of multiple ideologies and practices. The author argues that while participatory methodologies may offer effective ways of beginning a research project, adoption of short PRA workshops in academic or project related research could lead to dangerously faulty representations of complex social worlds.
Kawasaki Syndrome: Is Exposure to Rug Shampoo Important?

• In the winter of 1982-1983, two clusters of cases of Kawasaki syndrome (KS) provided an opportunity to examine further the possible association among KS, antecedent illnesses, and carpet shampooing and related activities. The two clusters involved 16 patients with onsets between October and January, with seven cases occurring in two adjacent counties in New York (Herkimer and Oneida) and nine in Kent County, Michigan. None of the 11 children with KS included in a case-control study had been exposed to shampooed carpets during the month prior to the onset of KS. Only four (36%) of 11 children with KS, compared with 13 (59%) of 22 control subjects, reported a respiratory antecedent illness within 30 days prior to the onset of KS (odds ratio = 0.50, 95% confidence limits = 0.12 to 2.03). The previously observed associations of KS with antecedent respiratory illness and carpet shampooing remain unexplained and undocumented in these outbreaks. (AJDC1985;139:777-779)
DegS and RseP Homologous Proteases Are Involved in Singlet Oxygen Dependent Activation of RpoE in Rhodobacter sphaeroides

Singlet oxygen (1O2) is the main agent of photooxidative stress and is generated by photosensitizers as (bacterio)chlorophylls. It leads to the damage of cellular macromolecules and therefore photosynthetic organisms have to mount an adaptive response to 1O2 formation. A major player of the photooxidative stress response in Rhodobacter sphaeroides is the alternative sigma factor RpoE, which is inactivated under non-stress conditions by its cognate anti-sigma factor ChrR. By using random mutagenesis we identified RSP_1090 to be required for full activation of the RpoE response under 1O2 stress, but not under organic peroxide stress. In this study we show that both RSP_1090 and RSP_1091 are required for full resistance towards 1O2. Moreover, we revealed that the DegS and RseP homologs RSP_3242 and RSP_2710 contribute to 1O2 resistance and promote ChrR proteolysis. The RpoE signaling pathway in R. sphaeroides is therefore highly similar to that of Escherichia coli, although very different anti-sigma factors control RpoE activity. Based on the acquired results, the current model for RpoE activation in response to 1O2 exposure in R. sphaeroides was extended.
Interleukin‐1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C

Excessive activation of glutamate receptors in spinal dorsal horn neurons is a key mechanism leading to abnormal neuronal activation in pathological pain conditions. Previous studies have shown that activation of glutamate receptors in the spinal dorsal horn is enhanced by impaired glial glutamate transporter functions and proinflammatory cytokines including interleukin‐1 beta (IL‐1β). In this study, we for the first time revealed that spinal glial glutamate transporter activities in the neuropathic animals are attenuated by endogenous IL‐1β. Specifically, we demonstrated that nerve injury results in an increased expression of IL‐1β and activation of PKC in the spinal dorsal horn as well as suppression of glial glutamate uptake activities. We provided evidence that the nerve‐injury induced suppression of glial glutamate uptake is at least in part ascribed to endogenous IL‐1β and activation of PKC in the spinal dorsal horn. IL‐1β reduces glial glutamate transporter activities through enhancing the endocytosis of both GLT‐1 and GLAST glial glutamate transporters. The IL‐1β induced trafficking of glial glutamate transporters is through the calcium/PKC signaling pathway, and the dynamin‐dependent endocytosis, which is dependent on the integrity of actin filaments. The signaling pathway regulating glial glutamate transporters revealed in this study provides novel targets to attenuate aberrant activation of glutamate receptors in the spinal dorsal horn, which could ultimately help the development of analgesics. GLIA 2014;62:1093–1109