Miracle-dz/UniFAR-FTUs huggingface dataset:
Small is not always beautiful

Peer-to-peer content distribution systems have been enjoying great popularity, and are now gaining momentum as a means of disseminating video streams over the Internet. In many of these protocols, including the popular BitTorrent, content is split into mostly fixed-size pieces, allowing a client to download data from many peers simultaneously. This makes piece size potentially critical for performance. However, previous research efforts have largely overlooked this parameter, opting to focus on others instead. This paper presents the results of real experiments with varying piece sizes on a controlled Bit-Torrent testbed.We demonstrate that this parameter is indeed critical, as it determines the degree of parallelism in the system, and we investigate optimal piece sizes for distributing small and large content. We also pinpoint a related design tradeoff, and explain how BitTorrent's choice of dividing pieces into subpieces attempts to address it.
Circular flows of nearly Eulerian graphs and vertex‐splitting

The odd edge connectivity of a graph G, denoted by λo(G), is the size of a smallest odd edge cut of the graph. Let S be any given surface and ϵ be a positive real number. We proved that there is a function fS(ϵ) (depends on the surface S and limϵ→0 fS(ϵ)=∞) such that any graph G embedded in S with the odd‐edge connectivity at least fS(ϵ) admits a nowhere‐zero circular (2+ϵ)‐flow. Another major result of the work is a new vertex splitting lemma which maintains the old edge connectivity and graph embedding. © 2002 Wiley Periodicals, Inc. J Graph Theory 40: 147–161, 2002
Training Early Literacy Related Skills: To Which Degree Does a Musical Training Contribute to Phonological Awareness Development?

Well-developed phonological awareness skills are a core prerequisite for early literacy development. Although effective phonological awareness training programs exist, children at risk often do not reach similar levels of phonological awareness after the intervention as children with normally developed skills. Based on theoretical considerations and first promising results the present study explores effects of an early musical training in combination with a conventional phonological training in children with weak phonological awareness skills. Using a quasi-experimental pretest-posttest control group design and measurements across a period of 2 years, we tested the effects of two interventions: a consecutive combination of a musical and a phonological training and a phonological training alone. The design made it possible to disentangle effects of the musical training alone as well the effects of its combination with the phonological training. The outcome measures of these groups were compared with the control group with multivariate analyses, controlling for a number of background variables. The sample included N = 424 German-speaking children aged 4–5 years at the beginning of the study. We found a positive relationship between musical abilities and phonological awareness. Yet, whereas the well-established phonological training produced the expected effects, adding a musical training did not contribute significantly to phonological awareness development. Training effects were partly dependent on the initial level of phonological awareness. Possible reasons for the lack of training effects in the musical part of the combination condition as well as practical implications for early literacy education are discussed.
Spatio-Temporal Mapping of Plate Boundary Faults in California Using Geodetic Imaging

The Pacific–North American plate boundary in California is composed of a 400-km-wide network of faults and zones of distributed deformation. Earthquakes, even large ones, can occur along individual or combinations of faults within the larger plate boundary system. While research often focuses on the primary and secondary faults, holistic study of the plate boundary is required to answer several fundamental questions. How do plate boundary motions partition across California faults? How do faults within the plate boundary interact during earthquakes? What fraction of strain accumulation is relieved aseismically and does this provide limits on fault rupture propagation? Geodetic imaging, broadly defined as measurement of crustal deformation and topography of the Earth’s surface, enables assessment of topographic characteristics and the spatio-temporal behavior of the Earth’s crust. We focus here on crustal deformation observed with continuous Global Positioning System (GPS) data and Interferometric Synthetic Aperture Radar (InSAR) from NASA’s airborne UAVSAR platform, and on high-resolution topography acquired from lidar and Structure from Motion (SfM) methods. Combined, these measurements are used to identify active structures, past ruptures, transient motions, and distribution of deformation. The observations inform estimates of the mechanical and geometric properties of faults. We discuss five areas in California as examples of different fault behavior, fault maturity and times within the earthquake cycle: the M6.0 2014 South Napa earthquake rupture, the San Jacinto fault, the creeping and locked Carrizo sections of the San Andreas fault, the Landers rupture in the Eastern California Shear Zone, and the convergence of the Eastern California Shear Zone and San Andreas fault in southern California. These examples indicate that distribution of crustal deformation can be measured using interferometric synthetic aperture radar (InSAR), Global Navigation Satellite System (GNSS), and high-resolution topography and can improve our understanding of tectonic deformation and rupture characteristics within the broad plate boundary zone.
Genetic algorithms applied to multi-class prediction for the analysis of gene expression data

MOTIVATION An important challenge in the use of large-scale gene expression data for biological classification occurs when the expression dataset being analyzed involves multiple classes. Key issues that need to be addressed under such circumstances are the efficient selection of good predictive gene groups from datasets that are inherently 'noisy', and the development of new methodologies that can enhance the successful classification of these complex datasets. METHODS We have applied genetic algorithms (GAs) to the problem of multi-class prediction. A GA-based gene selection scheme is described that automatically determines the members of a predictive gene group, as well as the optimal group size, that maximizes classification success using a maximum likelihood (MLHD) classification method. RESULTS The GA/MLHD-based approach achieves higher classification accuracies than other published predictive methods on the same multi-class test dataset. It also permits substantial feature reduction in classifier genesets without compromising predictive accuracy. We propose that GA-based algorithms may represent a powerful new tool in the analysis and exploration of complex multi-class gene expression data. AVAILABILITY Supplementary information, data sets and source codes are available at http://www.omniarray. com/bioinformatics/GA.
Timing and Duration of Interventions in Clinical Trials for Patients With Hospitalized Heart Failure

There are more than a million hospitalizations for heart failure (HHF) annually in the United States1 and >80% of them occur in patients with known chronic heart failure (HF). 2,3 These patients have a combined mortality and readmission rate of 35% to 40% within 90 days, a readmission rate of 25% within 30 days, and a mortality rate of 30% within a year after discharge.1 Many trials have been conducted on these patients and yet there are no approved therapies for these patients with proven efficacy for reducing mortality or readmission.4–12 There are many reasons for this,13 including the lack of consensus on therapeutic targets and aims. Most trials have focused on short-term dyspnea, but the rapid response to conventional therapy may indicate that dyspnea relief is a largely a met need. These trials have generally intervened by infusing investigational drugs for 2 to 3 days early in the hospital course signifying a philosophy that HHF represents an acute disease with distinct pathophysiology, like acute myocardial infarction, where short-term interventions can improve outcomes13 (Figure 1). Myocardial infarction, however, represents a truly acute onset of a distinct pathophysiology (ie, plaque rupture and thrombus formation). Whether HHF is an acute disease representing a distinct pathophysiology is uncertain. The selection of timing and duration of novel intervention among patients with HHF is rooted on fundamental concepts on the acuity of the disease process, its pathophysiology, the timing of adverse events, and past experience. Figure 1. Clinical trials in patients hospitalized for heart failure. Most trials initiated and terminated novel therapies during the acute stages of management. ACTIV indicates Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Congestive Heart Failure; ASCEND, Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure; ASTRONAUT, Aliskiren Therapy …
Interaction of Organic Cations with Organic Anion Transporters*

Studies of the organic anion transporters (Oats) have focused mainly on their interactions with organic anionic substrates. However, as suggested when Oat1 was originally identified as NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., and Nigam, S. K. (1997) J. Biol. Chem. 272, 6471–6478), since the Oats share close homology with organic cation transporters (Octs), it is possible that Oats interact with cations as well. We now show that mouse Oat1 (mOat1) and mOat3 and, to a lesser degree, mOat6 bind a number of “prototypical” Oct substrates, including 1-methyl-4-phenylpyridinium. In addition to oocyte expression assays, we have tested binding of organic cations to Oat1 and Oat3 in ex vivo assays by analyzing interactions in kidney organ cultures deficient in Oat1 and Oat3. We also demonstrate that mOat3 transports organic cations such as 1-methyl-4-phenylpyridinium and cimetidine. A pharmacophore based on the binding affinities of the tested organic cations for Oat3 was generated. Using this pharmacophore, we screened a chemical library and were able to identify novel cationic compounds that bound to Oat1 and Oat3. These compounds bound Oat3 with an affinity higher than the highest affinity compounds in the original set of prototypical Oct substrates. Thus, whereas Oat1, Oat3, and Oat6 appear to function largely in organic anion transport, they also bind and transport some organic cations. These findings could be of clinical significance, since drugs and metabolites that under normal physiological conditions do not bind to the Oats may undergo changes in charge and become Oat substrates during pathologic conditions wherein significant variations in body fluid pH occur.
Is School Type Associated with Objectively Measured Physical Activity in 15-Year-Olds?

The main aims of this study were: (1) to determine the objectively assessed physical activity (PA) patterns in urban 15-year-old male and female adolescents according to school type and (2) to assess the differences in PA between school days and weekend days. In this cross-sectional study, participants were 187 secondary-school male and female adolescents (61.4% females) attending grammar and vocational schools. Patterns of PA were objectively evaluated using a multi-sensor body monitor for 5 consecutive days. Confounders assessed included biological age, socio-economic status, sum of 4 skinfolds, maximal temperature and the amount of rainfall. Males and females from grammar schools achieved higher total daily energy expenditure (TEE) and active energy expenditure (AEE) compared to their peers from vocational schools (TEE: 50 ± 12 kcal/kg/day vs. 47 ± 12 kcal/kg/day, p = 0.02; AEE: 23 ± 5 kcal/kg/day vs. vocational = 21 ± 6 kcal/kg/day, p = 0.04). No differences in time spent in light (LPA), moderate (MPA) or vigorous (VPA) physical activity were noted between the two groups (p = 0.16–0.43). Next, a significant decline in TEE and MPA between school days and weekends was observed (p< 0.001 and p = 0.02, respectively), while VPA remained the same throughout the week (p = 0.76). Weekly patterns of PA did not show differences by school type or gender (p for interactions = 0.21–0.50). In addition, significantly lower amount of MPA was accumulated during weekends compared to school days, resulting in lower TEE, regardless of school type or gender. Policies and strategies on PA in adolescents should focus vocational schools and weekend days.
Unstable Binocular Fixation Affects Reaction Times But Not Implicit Motor Learning in Dyslexia.

Purpose Individuals with developmental dyslexia suffer not only from reading problems as more general motor deficits can also be observed in this patient group. Both psychometric clinical tests and objective eyetracking methods suggest that unstable binocular fixation may contribute to reading problems. Because binocular instability may cause poor eye-hand coordination and impair motor control, the primary aim of this study was to explore in dyslexic subjects the influence of unstable binocular fixation on reaction times (RTs) and implicit motor learning (IML), which is one of the fundamental cerebellar functions. Methods Fixation disparity (FD) and instability of FD were assessed subjectively using the Wesson card and a modified Mallett test. A modified version of the Serial Reaction Time Task (SRTT) was used to measure the RTs and IML skills. The results for the dyslexic group (DG), which included 29 adult subjects (15 were tested binocularly, DGbin; 14 were tested monocularly, DGmono), were compared with data from the control group (CG), which consisted of 30 age-matched nondyslexic subjects (15 tested binocularly, CGbin; and the other 15 tested monocularly, CGmono). Results The results indicated that the DG showed poorer binocular stability and longer RTs in the groups tested binocularly (RTs: 534 vs. 411 ms for DGbin and CGbin, respectively; P < 0.001) as compared with the groups examined monocularly (RTs: 431 vs. 424 ms for DGmono and CGmono, respectively; P = 0.996). The DG also exhibited impaired IML when compared with the CG (EFIML: 25 vs. 50 ms for DG and CG, respectively; P = 0.012). Conclusions Unstable binocularity in dyslexia may affect RTs but was not related to poor IML skills. Impaired IML in dyslexia was independent of the viewing conditions (monocular versus binocular) and may be related to cerebellar deficits.
The influence of the emergence profile on the amount of undetected cement excess after delivery of cement‐retained implant reconstructions

OBJECTIVE To test whether or not one of two emergence profile designs (concave or convex) is superior to the other in terms of remaining cement following cementation of reconstructions on individualized abutments and careful cement removal. MATERIALS AND METHODS A central incisor with a single implant-supported reconstruction was selected as a model. Six types of abutments (n = 10) with two different emergence profile designs (concave (CC) and convex (CV)) and three crown-abutment margin depths (epimucosal, 1.5 mm submucosal, 3 mm submucosal) were fabricated through a CAD/CAM procedure. Lithium disilicate reinforced ceramic crowns were cemented with chemically polymerized resin cement. A blinded investigator attempted to remove all cement excess. Thereafter, the entire reconstruction was unscrewed and analyzed for the overall amount and the depth of cement excess. Kruskal-Wallis and Mann-Whitney tests were used to investigate differences between groups. When more than two groups were compared between each other, a Bonferroni correction of the P value was performed. RESULTS Concave abutments presented significantly more cement remnants than CV abutments when the entire abutment area of the epimucosal margin groups was evaluated (CC0 mm: mean 2.31 mm2 (SD 0.99) vs. CV0 mm: mean 1.57 mm2 (SD 0.55); P = 0.043). A statistically significant increase in remnants was detected when the crown-abutment margin was located more submucosally for every abutment studied (0 mm vs. 1.5 mm: P < 0.000, 0 mm vs 3 mm: P < 0.000, 1.5 mm vs. 3 mm: P < 0.000). The buccal quadrant demonstrated the least, whereas the oral and interdental quadrants showed the greatest amount of cement excess. CONCLUSIONS Concave emergence profile abutments and deep crown-abutment margin positions increased the risk of cement excess. Oral and interdental areas are more prone to cement remnants than other surface areas.
Mechanical Properties of Electrodeposited Ni-SiO2 Nanocomposite

Nanocomposite materials consisting of a nanocrystalline Ni matrix with grain size ranging from 23 to 40 nm, and nano-size SiO2 particles with average particle size of 7 nm, have been produced by pulse electrodeposition. Grain size was controlled by peak current density. It was observed that SiO2 particles precipitated within grain interior by the transmission electron microscopy (TEM). Hardness and tensile strength of nanocomposites with a grain size larger than 35 nm was higher than that of nanocrystalline pure Ni possibly as a consequence of Orowan precipitation hardening. However, hardness of Ni-SiO2 nanocomposites with a grain size smaller than 30 nm was the same as that of nanocrystalline pure Ni. It was considered that the SiO2 particles do not contribute to hardening because deformation occurs by a grain-boundary-mediated mechanism such as grain-boundary sliding.
Optimal Effort Incentives in Dynamic Tournaments

This paper analyzes two-stage rank-order tournaments. A principal decides (i) how to spread prize money across the two periods, (ii) how to weigh performance in the two periods when awarding the second period prize, and (iii) whether to reveal performance after the first period. The information revelation policy depends exclusively on properties of the effort cost function. The principal always puts a positive weight on first-period performance in the second period. The size of the weight and the optimal prizes depend on properties of the observation error distribution; they should be chosen so as to strike a balance between the competitiveness of first- and second-period tournaments. In particular, the principal sets no first-period prize unless the observations in period one are considerably more precise than in period two.
Influence of shrinkage-reducing admixture on drying shrinkage and mechanical properties of high-performance concrete

Abstract High-performance concrete (HPC) has specific performance advantages over conventional concrete in strength and durability. HPC mixtures are usually produced with water/binder mass ratios ( m W / m B ) in the range of 0.2–0.4, so volume changes of concrete as a result of drying, chemical reactions, and temperature change cannot be avoided. For these reasons, shrinkage and cracking are frequent phenomena. It is necessary to add some types of admixture for reduction of shrinkage and cracking of HPC. This study used
Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial

Recently it has been reported that the estimated glomerular filtration rate (eGFR) is higher in habitual coffee consumers than in noncoffee consumers. However, the causality remains unclear. Therefore, we conducted a clinical trial to investigate the effects of coffee consumption on kidney function. Nineteen asymptomatic nonsmokers aged 21–27 years old participated in this study. They consumed coffee (18 g coffee beans/450 mL per day) or green tea as a comparator for 2 weeks in a crossover design. Although creatinine-based eGFR was not affected after consuming either beverage, all cystatin-C-based eGFRs determined using five different equations were significantly increased after coffee consumption (means: 5.0–7.7%), but not after green tea consumption (means: 0.1–1.6%). Serum adiponectin and magnesium levels increased significantly after coffee consumption (means: 13.6% and 4.3%, resp.), but not after green tea consumption. These findings suggest that even a short period of coffee consumption may increase cystatin-C-based eGFR, along with favorable changes in serum adiponectin, in healthy young adults.
Microsatellite instability detection by next generation sequencing.

BACKGROUND Microsatellite instability (MSI) is a useful phenotype in cancer diagnosis and prognosis. Nevertheless, methods to detect MSI status from next generation DNA sequencing (NGS) data are underdeveloped. METHODS We developed an approach to detect the MSI phenotype using NGS (mSINGS). The method was used to evaluate mononucleotide microsatellite loci that were incidentally sequenced after targeted gene enrichment and could be applied to gene or exome capture panels designed for other purposes. For each microsatellite locus, the number of differently sized repeats in experimental samples were quantified and compared to a population of normal controls. Loci were considered unstable if the experimental number of repeats was statistically greater than in the control population. MSI status was determined by the fraction of unstable microsatellite loci. RESULTS We examined data from 324 samples generated using targeted gene capture assays of 3 different sizes, ranging from a 0.85-Mb to a 44-Mb exome design and incorporating from 15 to 2957 microsatellite markers. When we compared mSING results to MSI-PCR as a gold standard for 108 cases, we found the approach to be both diagnostically sensitive (range of 96.4% to 100% across 3 panels) and specific (range of 97.2% to 100%) for determining MSI status. The fraction of unstable microsatellite markers calculated from sequencing data correlated with the number of unstable loci detected by conventional MSI-PCR testing. CONCLUSIONS NGS data can enable highly accurate detection of MSI, even from limited capture designs. This novel approach offers several advantages over existing PCR-based methods.
Determining Management Information Needs: A Comparison of Methods

This paper reports on a comparison of the decision analysis (topdown) and data analysis (bottom-up) methods for determining management information needs in the preparation of management-oriented information system applications. Information requirements were developed using the two alternative methods for four decisions in each of four small colleges. The information requirements obtained by the two methods were evaluated by the college executives as to value and other attributes. The results indicate: l. The methods perform better in some functional areas (e.g ., administrative) than in others (e.g ., academic). 2. The type of decision, programmed or nonprogrammed, affected the value and attributes of information obtained. The decision analysis approach provided a higher valued set of information requirements for programmed decisions than data analysis;for relatively nonprogrammed decisions. both methods were about equal in providing information requirements. The value and attributes assigned to the information requirements were higher for programmed decisions than for nonprogrammed decisions. 3. Information analysis techniques cannot be considered apart from organizational contexts in which they are to be applied.