Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase-Change and Redox-Based Resistive Switching Memories

This paper addresses the two main resistive switching (RS) memory technologies: phase-change memory (PCM) and redox-based resistive random access memory (ReRAM). It will review the basic concepts, the initial promises, and current state of the art, with focus on possible scaling pathways for low-power operation and dense, true 3-D memory. Recent physical insights and new potential concepts will be discussed.
apertium-cy - a collaboratively-developed free RBMT system for Welsh to English

apertium-cy - a collaboratively-developed free RBMT system for Welsh to English apertium-cy (http://www.cymraeg.org.uk) is a rule-based "gisting" machine translation system for Welsh to English, with both engine and data released under the GPL. We summarise the development of apertium-cy, evaluate its output, and discuss the advantages of a collaborative development model combined with rule-based MT for marginalised languages.
Genetic profiling in healthy subjects from the Stanislas cohort based on 24 polymorphisms: effects on biological variables

Abstract Background: The association of genetic profiles with biological or clinical assessments is not clearly established especially among apparently healthy subjects. Methods: A multivariate statistical analysis was performed on 24 polymorphisms related to the main metabolic pathways involved in cardiovascular diseases (CVDs). They were collected among 1551 healthy subjects of the Stanislas cohort to obtain genetic profiles. Association with biological variables was then studied at baseline (t0) and 5 years later (t5). Results: Six genetic clusters were identified with relevant profiles and five polymorphisms from the selectin, apolipoprotein C3 and lipoprotein lipase genes (SELE-98G/T, APOC3–3175C/G, APOC3–482C/T, APOC3–1100C/T, LPL–93T/G) were sufficiently characteristic to associate 99.6% of the subjects with their corresponding cluster. A 5-year follow-up showed that clinical and biological measurements in relation to CVD risk factors already differ with triglyceride (p=0.009 for t0 and p=0.005 for t5) and high-density lipoprotein cholesterol (p=0.014 for t0 and p=0.003 for t5) for these previous genetic clusters. Conclusions: This study presents the hypothesis that SELE could be protective, whereas APOC3 could be associated with risk. It remains to be seen whether these polymorphisms will be predictive of CVD events among the selected clusters of different metabolic subtypes after a 10-year follow-up. Clin Chem Lab Med 2008;46:64–72.
Enhancement of emission and directionality of Light Emitting Diode using Surface Plasmon Resonance

Emission of the LED can be enhanced by Surface Plasmons Resonance (SPRs), which are electron oscillations that can exist at the interface between a metal and dielectric materials. The mechanism is reliant upon the energy coupling effect between the emitted photons from the semiconductor and arranged metallic nanoparticles. The focus of this theoretical investigation is study the interaction between light and the metallic film, explicitly Ag and Au, deposited onto the surface of a light emitting diode (LED), which is proposed to allow coupling between surface plasmons and free-space photons. Moreover, it’s also demonstrated how the optical emission from a typical light of LED device can be spatially controlled through the deposition of a periodically structured metallic film. This theoretical investigation indicated that high-efficiency and spatially controlled direction light emission can be predicted for light emitters. This can be done through the best selection of the proposed parameters (λ=547.6nm and ʌ=660nm) and area of overlapping the circles of wave vectors for light in free space and surface plasmons. It is also appeared that the coupling between the free photons and surface plasmons is optimumfor the proposed wavelengths
REDUNDANCY OR MISMEASUREMENT? A REAPPRAISAL OF MONEY

The emerging consensus in monetary policy and business cycle analysis is that money aggregates are not useful as an intermediate target for monetary policy or as an information variable. The uselessness of money as an intermediate target is driven, at least in part, by empirical research that suggests that money demand is unstable. In addition, the informational quality of money has been called into question by empirical research that fails to identify a relationship between money growth and inflation, nominal income growth, and the output gap. Nevertheless, this research is potentially flawed by the use of simple sum money aggregates, which are not consistent with economic, aggregation, or index number theory. This paper therefore reexamines previous empirical evidence on money demand and the role of money as an information variable, using Divisia monetary aggregates. These aggregates have the advantage of being derived from microtheoretic foundations, as well as being consistent with aggregation and index number theory. The results of the reevaluation suggest that previous empirical work might be driven by mismeasurement.
Accuracy of 2 Activity Monitors in Detecting Steps in People With Stroke and Traumatic Brain Injury

Background Advances in sensor technologies and signal processing techniques provide a method to accurately measure walking activity in the home and community. Activity monitors geared toward consumer or patient use may be an alternative to more expensive monitors designed for research to measure stepping activity. Objective The objective of this study was to examine the accuracy of 2 consumer/patient activity monitors, the Fitbit Ultra and the Nike+ Fuelband, in identifying stepping activity in people with stroke and traumatic brain injury (TBI). Secondarily, the study sought to compare the accuracy of these 2 activity monitors with that of the StepWatch Activity Monitor (SAM) and a pedometer, the Yamax Digi-Walker SW-701 pedometer (YDWP). Design A cross-sectional design was used for this study. Method People with chronic stroke and TBI wore the 4 activity monitors while they performed the Two-Minute Walk Test (2MWT), during which they were videotaped. Activity monitor estimated steps taken were compared with actual steps taken counted from videotape. Accuracy and agreement between activity monitor estimated steps and actual steps were examined using intraclass correlation coefficients (ICC [2,1]) and the Bland-Altman method. Results The SAM demonstrated the greatest accuracy (ICC [2,1]=.97, mean difference between actual steps and SAM estimated steps=4.7 steps) followed by the Fitbit Ultra (ICC [2,1]=.73, mean difference between actual steps and Fitbit Ultra estimated steps=−9.7 steps), the YDWP (ICC [2,1]=.42, mean difference between actual steps and YDWP estimated steps=−28.8 steps), and the Nike+ Fuelband (ICC [2,1]=.20, mean difference between actual steps and Nike+ Fuelband estimated steps=−66.2 steps). Limitations Walking activity was measured over a short distance in a closed environment, and participants were high functioning ambulators, with a mean gait speed of 0.93 m/s. Conclusions The Fitbit Ultra may be a low-cost alternative to measure the stepping activity in level, predictable environments of people with stroke and TBI who can walk at speeds ≥0.58 m/s.
Clinical Severity of Gitelman Syndrome Determined by Serum Magnesium

Background/Aims: Normomagnesemia is considered atypical in Gitelman syndrome (GS). Here, we describe clinical, pathological and genetic characteristics in Chinese GS patients with or without hypomagnesemia in order to determine whether serum magnesium concentration indicates the severity of the disease. Methods: 7 normomagnesemic and 25 hypomagnesemic GS patients who were confirmed by direct sequencing of SLC12A3 gene were included. Clinical manifestation and laboratory tests were documented. Supine and upright plasma renin activity, angiotensin II and aldosterone were determined by radioimmunoassay. Transient receptor potential channel melastatin subtype 6 (TRPM6) was detected by immunohistochemistry in paraffin-embedded renal biopsy sections of 12 GS patients. 14 patients with glomerular minor lesion served as controls. The distribution of the mutations on the predicted NCC protein was analyzed and compared between two subgroups. Results: Clinical manifestations, electrolyte abnormalities, metabolic alkalosis and renin-angiotensin-aldosterone system activation were found to be milder in normomagnesemic compared with the hypomagnesemic group. Compared with glomerular minor lesion controls, the TRPM6-positive area was significantly decreased in hypomagnesemic patients (4.96 ± 1.88 vs. 8.63 ± 2.67%) while it was near normal (7.82 ± 5.23%) in 2 normomagnesemic GS patients. A higher percentage of intracellular mutations was observed in normomagnesemic patients than hypomagnesemic patients (92.31 vs. 56.52%, p = 0.02). Conclusions: Normomagnesemia is not rare in GS. Serum magnesium may indicate the severity of GS.
Demographic and Etiological Patterns of Gastric Outlet Obstruction in Kerala, South India

Background: In the modern era, the major cause of gastric outlet obstruction (GOO) is known to be a malignancy, especially in the developed world. Many books and articles do suggest that the benign causes continue to be the major cause of GOO in the developing world however, there is growing evidence proving the contrary. Males were (more commonly) affected females and individuals in their fifth and sixth decade have been the predominant age group in the majority of studies. There is a minimal data of GOO from South India. Aims: A retrospective analysis of the endoscopic findings of patients presenting with features of GOO to determine the demographic and etiological patterns. Materials and Methods: A retrospective study of the endoscopic findings of patients with GOO from January 2005 to January 2014 was done. The diagnosis of GOO was based on clinical presentation, and an inability during the upper endoscopy to enter the second portion of the duodenum as documented in the endoscopy registers. Patients who have already been diagnosed with malignancy prior to the endoscopy were excluded from the study; so were the patients with gastroparesis. Results: A total of 342 patients with GOO underwent the endoscopy during the study period. The causes for benign obstruction were predominantly peptic ulcer disease. The major cause for malignant obstruction was carcinoma of stomach involving the distal stomach. The male to female ratio was 3.2:1. The patients with malignancy were older than patients with benign disorders. Most of the patients were in the sixth and seventh decade. The risk of malignancy was higher with increasing age, especially in women. A fourth of all carcinoma stomach presented with GOO. Conclusion: The study demonstrates that the cause for GOO in Kerala, South India is predominantly malignancy. The etiological and demographic patterns were similar to the studies conducted in the developed nations.
Contraction and stability analysis of steady-states for open quantum systems described by Lindblad differential equations

For discrete-time quantum systems, governed by Kraus maps, the work of D. Petz has characterized the set of universal contraction metrics. In the present paper, we use this characterization to derive a set of quadratic Lyapunov functions for continuous-time systems, governed by Lindblad differential equations, that have a steady-state with full rank. An extremity of this set is given by the Bures metric, for which the quadratic Lyapunov function is obtained by inverting a Sylvester equation. We illustrate the method by providing a strict Lyapunov function for a Lindblad equation designed to stabilize a quantum electrodynamic “cat” state by reservoir engineering. In fact we prove that any Lindblad equation on the Hilbert space of the (truncated) harmonic oscillator, which has a full-rank equilibrium and which has, among its decoherence channels, a channel corresponding to the photon loss operator, globally converges to that equilibrium.
Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase

ABSTRACT BMS-791325 is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. Potency against genotype 6a showed more variability (9 to 125 nM), and activity was weaker against genotype 2 (EC50, 87 to 925 nM). Specificity was demonstrated by the absence of activity (EC50s of >4 μM) against a panel of mammalian viruses, and cytotoxic concentrations (50%) were >3,000-fold above the HCV EC50. Resistance substitutions selected by BMS-791325 in genotype 1 replicons mostly mapped to a single site, NS5B amino acid 495 (P495A/S/L/T). Additive or synergistic activity was observed in combination studies using BMS-791325 with alfa interferon plus ribavirin, inhibitors of NS3 protease or NS5A, and other classes of NS5B inhibitor (palm site 2-binding or nucleoside analogs). Plasma and liver exposures in vivo in several animal species indicated that BMS-791325 has a hepatotropic disposition (liver-to-plasma ratios ranging from 1.6- to 60-fold across species). Twenty-four hours postdose, liver exposures across all species tested were ≥10-fold above the inhibitor EC50s observed with HCV genotype 1 replicons. These findings support the evaluation of BMS-791325 in combination regimens for the treatment of HCV. Phase 3 studies are ongoing.
Non‐invasive CT screening for pulmonary arteriovenous malformations in children with confirmed hereditary hemorrhagic telangiectasia: Results from two pediatric centers

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder that is caused by mutations in mainly two genes, that is ENG, encoding endoglin (HHT1), or ACVRL1, encoding activin receptor‐like kinase 1 (ALK‐1/HHT2). HHT is characterized by recurrent epistaxis, mucocutaneous telangiectasia, and vascular visceral dysplasia responsible for visceral arteriovenous malformations (AVM).
How specific are negative symptoms and cognitive impairment in schizophrenia? An analysis of PANSS and SCoRS

Introduction. Interview-based scales can be used as coprimary measures to complement the assessment of cognitive impairment in schizophrenia. One major question that arises from the use of such tools is how specific they are in relation to other psychopathological domains. We analyse the specificity of the Positive and Negative Syndrome Scale (PANSS) negative subscale and the Schizophrenia Cognition Rating Scale (SCoRS). Methods. We performed a principal component analysis (PCA) of PANSS negative subscale, rated by the interviewer, and SCoRS ratings from three different sources (patient, informant, and interviewer) in 101 patients with schizophrenia. Additionally, we correlated mean SCoRS ratings to PANSS negative subscale items to determine whether any PANSS item is particularly related to cognition. Results. The PCA showed that the two first components, which explained approximately 40% of the total variance of the scales, represent the SCoRS ratings and the PANSS negative subscale ratings, respectively. The mean interviewer SCoRS was significantly correlated with the PANSS negative Item 5 (difficulty in abstract thinking) and with the mean PANSS negative subscale. The latter correlation was no longer significant when “difficulty in abstract thinking” was eliminated from PANSS negative subscale. Conclusions. In general, SCoRS and PANSS negative subscale scores address different constructs; however, the PANSS negative item “difficulty in abstract thinking” seems to address a cognitive dimension.
Cross-reactive antigens shared by Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Haemophilus influenzae may cause false-positive titers of antibody to H. pylori

Cystic fibrosis (CF) patients suffer from many of the gastrointestinal conditions which occur in non-CF individuals, e.g., dyspepsia and peptic ulceration. These symptoms may be caused by Helicobacter pylori but could also be due to either pancreatic insufficiency or the intensive antibiotic treatment used in CF patients. Since CF patients chronically infected with Pseudomonas aeruginosa produce antibodies against a wide range of antigens, including antigens common to many other bacteria, e.g., GroEL and lipopolysaccharide, we studied, by the Western blot (immunoblot) technique, the specificity of immunoglobulin G antibodies to H. pylori in Danish CF patients chronically infected with P. aeruginosa, CF patients without P. aeruginosa infection but with Haemophilus influenzae infection, patients with dyspeptic ulcers associated with H. pylori, and patients recovering from acute Campylobacter jejuni or Campylobacter coli infection. Sera from CF patients with chronic P. aeruginosa or H. influenzae infection and patients recovering from acute C. jejuni infection cross-reacted with H. pylori antigens. A strong cross-reacting protein antigen at approximately 14 kDa and minor cross-reactive antigens at approximately 27, 30, and 60 kDa (the heat shock protein GroEL is equivalent to the common antigen of P. aeruginosa) could be demonstrated. The results of this study show that high immunoglobulin G antibody titers against H. pylori in CF patients cannot be regarded as indicating present or past H. pylori infection unless their specificity is proven by absorption studies.
Revealing components of the galaxy population through non-parametric techniques

The distributions of galaxy properties vary with environment, and are often multimodal, suggesting that the galaxy population may be a combination of multiple components. The behaviour of these components versus environment holds details about the processes of galaxy development. To release this information we apply a novel, non-parametric statistical technique, identifying four components present in the distribution of galaxy Hα emission-line equivalent widths. We interpret these components as passive, star forming and two varieties of active galactic nuclei. Independent of this interpretation, the properties of each component are remarkably constant as a function of environment. Only their relative proportions display substantial variation. The galaxy population thus appears to comprise distinct components which are individually independent of environment, with galaxies rapidly transitioning between components as they move into denser environments.
An Augmented Lagrangian Approach to Constrained MAP Inference

We propose a new algorithm for approximate MAP inference on factor graphs, by combining augmented Lagrangian optimization with the dual decomposition method. Each slave subproblem is given a quadratic penalty, which pushes toward faster consensus than in previous subgradient approaches. Our algorithm is provably convergent, parallelizable, and suitable for fine decompositions of the graph. We show how it can efficiently handle problems with (possibly global) structural constraints via simple sort operations. Experiments on synthetic and real-world data show that our approach compares favorably with the state-of-the-art.
A Semiparametric Missing‐Data‐Induced Intensity Method for Missing Covariate Data in Individually Matched Case–Control Studies

Summary In individually matched case–control studies, when some covariates are incomplete, an analysis based on the complete data may result in a large loss of information both in the missing and completely observed variables. This usually results in a bias and loss of efficiency. In this article, we propose a new method for handling the problem of missing covariate data based on a missing‐data‐induced intensity approach when the missingness mechanism does not depend on case–control status and show that this leads to a generalization of the missing indicator method. We derive the asymptotic properties of the estimates from the proposed method and, using an extensive simulation study, assess the finite sample performance in terms of bias, efficiency, and 95% confidence coverage under several missing data scenarios. We also make comparisons with complete‐case analysis (CCA) and some missing data methods that have been proposed previously. Our results indicate that, under the assumption of predictable missingness, the suggested method provides valid estimation of parameters, is more efficient than CCA, and is competitive with other, more complex methods of analysis. A case–control study of multiple myeloma risk and a polymorphism in the receptor Inter‐Leukin‐6 (IL‐6‐α) is used to illustrate our findings.
Vector Mode Analysis of Optical Waveguides by Quadratic Spline Collocation Method

We present an accurate, e-cient numerical analysis for vector modes of dielectric optical waveguide structures with an arbitrary refractive index proflle using a quadratic spline collocation method (QSCM). The unknown weights of the polynomials are determined by forcing the errors at the collocation points to be zero. Consequently, the original second order difierential equation is converted to a set of algebraic equations which can be solved by matrix techniques. The proposed QSCM method demonstrates better performance than the standard flnite-difierence method of the same convergence rate in terms of grid size with the same degree of computational complexity.
Modeling of shock boundary layer interactions and stability analysis using particle approaches

Hypersonic flow separation and laminar shock wave boundary layer interactions (SWBLIs) have received considerable attention since these interactions can lead to laminar to turbulent transition, unsteadiness, and localized high pressure and heating regions. Accurate predictions of these phenomena, particularly when thermochemical nonequilibrium is present, play a crucial role for design purposes. In this regard, many experimental, theoretical, and numerical works have been conducted over the decades. In this work, numerical investigations of SWBLIs for hypersonic flows over a double wedge and cone and ”tick-shaped” model configurations have been conducted to investigate the origin of SWBLIs and to compare with measurements in the Hypervelocity Expansion Tube (HET), Calspan-University at Buffalo Research Center (CUBRC), and T-ADFA free-piston shock tunnel facilities using particle approaches to model the Boltzmann equation. The Boltzmann transport equation is the most general formulation of binary gas flows for a wide Knudsen number spectrum including rarefied, slip, continuum regimes. The direct simulation Monte Carlo (DSMC) method, a well-known stochastic approach to solving the Boltzmann equation, provides high-fidelity molecular transport and thermal nonequilibrium, commonly seen in strong shock-shock interactions and inherently captures rarefaction effects such as velocity slip and temperature jump without a priori specific model. Therefore, the DSMC method has been applied to SWBLIs in order to take all these effects into account. However, DSMC becomes prohibitively expensive for calculations in the continuum regime. In order to potentially reduce the computational costs related to DSMC computations for low Knudsen number flows, the ellipsoidal statistical Bhatnagar-Gross-Krook (ES-BGK) model of the Boltzmann equation was developed and applied to shock dominated flows. The DSMC method has been used for modeling shock dominated separated hypersonic flows at Mach 7 for a unit Reynolds number of 4.15 × 10 m previously studied in the HET over a double wedge configuration to investigate the impacts of thermochemical effects on SWBLIs by changing the chemical composition. The DSMC simulations are found to reproduce many of the classical features of Edney Type IV strong shock interactions. A comparison of simulated heat flux with measurements reveals that the calculated surface