Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of concept and vee mappings under three learning modes on Jamaican eighth graders’ knowledge of nutrition and plant reproduction

The first objective of this study was to investigate if the experimental students’ post‐test knowledge of nutrition and plant reproduction would be improved more significantly than that of their control group counterparts based on their treatment, attitudes to science, self‐esteem, gender and socio‐economic background. Treatment involved teaching the experimental students under three learning modes—pure cooperative, cooperative–competitive and individualistic whole class interpersonal competitive condition—using concept and vee mappings and the lecture method. The control groups received the same treatment but were not exposed to concept and vee mappings. This study’s second objective was to determine which of the three learning modes would produce the highest post‐test mean gain in the subjects’ knowledge of the two biology concepts. The study’s sample comprised 932 eighth graders (12–13‐year‐olds) in 14 co‐educational comprehensive high schools randomly selected from two Jamaican parishes. An integrated science performance test, an attitudes to science questionnaire and a self‐esteem questionnaire were used to collect data. The results indicated that the experimental students (a) under the three learning modes, (b) with high, moderate, and low attitudes to science, and (c) with high, moderate, and low self‐esteem, performed significantly better than their control group counterparts. The individualist whole class learning mode engendered the highest mean gain on the experimental students’ knowledge, while the cooperative–competitive learning mode generated the highest mean gain for the control group students.
Cross Talk: The Microbiota and Neurodevelopmental Disorders

Humans evolved within a microbial ecosystem resulting in an interlinked physiology. The gut microbiota can signal to the brain via the immune system, the vagus nerve or other host-microbe interactions facilitated by gut hormones, regulation of tryptophan metabolism and microbial metabolites such as short chain fatty acids (SCFA), to influence brain development, function and behavior. Emerging evidence suggests that the gut microbiota may play a role in shaping cognitive networks encompassing emotional and social domains in neurodevelopmental disorders. Drawing upon pre-clinical and clinical evidence, we review the potential role of the gut microbiota in the origins and development of social and emotional domains related to Autism spectrum disorders (ASD) and schizophrenia. Small preliminary clinical studies have demonstrated gut microbiota alterations in both ASD and schizophrenia compared to healthy controls. However, we await the further development of mechanistic insights, together with large scale longitudinal clinical trials, that encompass a systems level dimensional approach, to investigate whether promising pre-clinical and initial clinical findings lead to clinical relevance.
Exploring the Conceptual Expansion within the Field of Organizational Behaviour: Organizational Climate and Organizational Culture

Developments within social and exact sciences take place because scientists engage in scientific practices that allow them to further expand and refine the scientific concepts within their scientific disciplines. There is disagreement among scientists as to what the essential practices are that allow scientific concepts within a scientific discipline to expand and evolve. One group looks at conceptual expansion as something that is being constrained by rational practices. Another group, however, suggests that conceptual expansion proceeds along the lines of ‘everything goes’. The goal of this paper is to test whether scientific concepts expand in a rational way within the field of organizational behaviour. We will use organizational climate and culture as examples. The essence of this study consists of two core concepts: one within organizational climate and one within organizational culture. It appears that several conceptual variations are added around these core concepts. The variations are constrained by rational scientific practices. In other terms, there is evidence that the field of organizational behaviour develops rationally
Cognitive Detection of Multiple Discrete Emotions from Chinese Online Reviews

Sentiment analysis is a hot topic in a couple of years. Emotion, an affective state expressed by human cognitive process, is widely embedded in user-generated content (UGC). Traditional research mainly focused on polarity and paid less attention to the nature of emotion that elicited from an underlying cognitive structure with multiple discrete dimensions. Informed by the OCC emotion model with hierarchical cognitive structure, we firstly detect and extract discrete emotions from online reviews of JD.com, one of the most famous electronic product marketplaces in China. Secondly, we propose an improved OCC-OR emotion model and select six prominent discrete emotions elicited from customer online behaviors and conditions. Thirdly, we validate the proposed emotion model into natural language processing and machine learning techniques. The performances of multiple discrete emotion detection in distributed Chinese semantic representation and classifiers prove the effects of OCC-OR emotion model, which can better demonstrate consumer cognitions in online shopping market. Our findings build up a solid theoretical foundation in sentiment analysis with a practical implication for future researchers.
The EBNA2 Polyproline Region Is Dispensable for Epstein-Barr Virus-Mediated Immortalization Maintenance

ABSTRACT Epstein-Barr virus nuclear antigen 2 (EBNA2) is required for EBV-mediated immortalization of primary human B cells and is a direct transcriptional activator of viral and cellular genes. The prototype EBNA2 protein contains a unique motif in which 43 out of 45 amino acids are prolines (polyproline region [PPR]). Previous genetic analysis has shown that deletion of the PPR resulted in viruses unable to immortalize B cells, although the protein did appear transcriptionally functional (R. Yalamanchili, S. Harada, and E. Kieff, J. Virol. 70:2468-2473, 1996). The PPR's uniqueness and requirement for immortalization make it an attractive therapeutic target. However, the role of this highly unusual motif for immortalization remains enigmatic. We have recently developed a transcomplementation assay that allows both genetic and functional analyses of EBNA2 in EBV-mediated immortalization maintenance (A. V. Gordadze, R. Peng, J. Tan, G. Liu, R. Sutton, B. Kempkes, G. W. Bornkamm, and P. D. Ling, J. Virol. 75:5899-5912, 2001). Surprisingly, we found that ΔPPR-EBNA2 was able to support B-cell proliferation similar to that of wild-type EBNA2 in this assay, indicating that deletion of the PPR from EBNA2 does not result in a loss of function required for immortalization maintenance. Further analysis of this mutant EBNA2 revealed that it consistently activated the viral LMP1 and LMP2A promoters severalfold better than wild-type EBNA2 in transient cotransfection assays. In addition, one striking difference between lymphoblastoid cell lines expressing wild-type EBNA2 from those expressing ΔPPR-EBNA2 is that the latter cells have significantly reduced EBV genomic levels. The data are consistent with a model in which lower EBNA2 target gene dosage may be selected for in ΔPPR-EBNA2-dependent cell lines to compensate for hyperactive stimulation of viral genes, such as LMP-1, which is cytostatic for B cells when overexpressed. It is conceivable that the hyperactivity rather than the loss of function, as hypothesized previously, could be responsible for the inability of recombinant ΔPPR-EBNA2 EBVs to immortalize B cells.
Contemporary Evangelicals: Born-Again and World Affirming

Because conservative Protestant activism in the 1970s and 1980s was motivated by moral concerns—a reaction to the further disestablishment of so-called traditional Christian values in American society—and because explanations of church growth have also centered on values and boundary maintenance—the strictchurches-grow thesis—resurgent evangelicalism has come to be understood as a reactionary social movement, that is, as though most evangelicals are fundamentalists. Serious students of religion know this is not the case, but it is easy to confound explanations of the popularity of born-again Christianity and the cultural politics of the new Christian Right. In this article, three features of contemporary American evangelicalism are examined that suggest born-again Christians are becoming more like their fellow Americans in their comfort with popular culture, which is to say they are less culturally conservative. Whether contemporary evangelicalism is understood to be sectarian or world affirming is consequential for explaining the prosperity of born-again Christianity and for discerning its future role in public life.
Global mapping of ZBTB7A transcription factor binding sites in HepG2 cells

ZBTB7A is a known proto-oncogene that is implicated in carcinogenesis and cell differentiation and development. Fully understanding the function of ZBTB7A in cellular processes could provide useful strategies for cancer treatment and development-associated disease therapy. Here, global mapping of ZBTB7A transcription factor binding sites was developed by utilizing microarray technology in HepG2 cells. The data obtained from the microarrays was further validated via chromatin immunoprecipitation-PCR (ChIP-PCR) and real time-PCR, and it was revealed that ZBTB7A may be one of the regulators of neural development. ZBTB7A target signal pathways were identified in signal pathway and GO (Gene Ontology) analyses. This is the first report on the global mapping of ZBTB7A downstream direct targets, and these findings will be useful in understanding the roles of ZBTB7A in cellular processes.
Do Narcissists Use Material Possessions as a Primary Buffer Against Pain?

Zhou and Gao (this issue) put forward the argument that social support is the primary and money is a secondary psychological buffer against pain. Social support is a symbolic and also actual shield against the perception of pain. Social support, however, is not always effective, according to the authors. When people feel rejected and socially excluded, they are not only devoid of vital resources, but such situations per se become a source of social anguish. The primary buffer fails, so an alternative system must be activated to shield individuals against distress and suffering. This secondary pain buffer is money. Thus, the reliance on money as a pain management system results from the failure of social support to serve that function. Zhou and Gao (this issue) acknowledge that individual differences may influence pain management mechanisms involved in coping with insecurity and suffering. They list three such variables: attachment style, collectivistic versus individualistic values, and gender. We propose another variable that we believe critically influences the strategies individuals deploy to cope with pain. This individual difference is narcissism. We hypothesize that, for narcissists, money is the primary buffer against pain, meaninglessness, and other existential problems.
Novel aspects of extracellular adenosine dynamics revealed by adenosine sensor cells

Adenosine modulates diverse physiological and pathological processes in the brain, including neuronal activities, blood flow, and inflammation. However, the mechanisms underlying the dynamics of extracellular adenosine are not fully understood. We have recently developed a novel biosensor, called an adenosine sensor cell, and we have characterized the neuronal and astrocytic pathways for elevating extracellular adenosine. In this review, the physiological implications and therapeutic potential of the pathways revealed by the adenosine sensor cells are discussed. We propose that the multiple pathways regulating extracellular adenosine allow for the diverse functions of this neuromodulator, and their malfunctions cause various neurological and psychiatric disorders.
Reconstruction of bandlimited signals from noisy data by adaptive thresholding

An adaptive thresholding scheme is proposed for reconstruction of bandlimited signals from noisy data without oversampling. An exact formula for mean integrated squared error of the proposed scheme gives better reconstruction accuracy than the classical Whittaker-Shannon interpolation scheme and the non-adaptive thresholding-based reconstruction scheme proposed in V. -L. Nguyen and M. Pawlak (2003).
Binding Specificities of the Telomere Phage ϕKO2 Prophage Repressor CB and Lytic Repressor Cro

Temperate bacteriophages possess a genetic switch which regulates the lytic and lysogenic cycle. The genomes of the temperate telomere phages N15, PY54, and ϕKO2 harbor a primary immunity region (immB) comprising genes for the prophage repressor (cI or cB), the lytic repressor (cro) and a putative antiterminator (q). The roles of these products are thought to be similar to those of the lambda proteins CI (CI prophage repressor), Cro (Cro repressor), and Q (antiterminator Q), respectively. Moreover, the gene order and the location of several operator sites in the prototype telomere phage N15 and in ϕKO2 are reminiscent of lambda-like phages. We determined binding sites of the ϕKO2 prophage repressor CB and lytic repressor Cro on the ϕKO2 genome in detail by electrophoretic mobility shift assay (EMSA) studies. Unexpectedly, ϕKO2 CB and Cro revealed different binding specificities. CB was bound to three OR operators in the intergenic region between cB and cro, two OL operators between cB and the replication gene repA and even to operators of N15. Cro bound exclusively to the 16 bp operator site OR3 upstream of the ϕKO2 prophage repressor gene. The ϕKO2 genes cB and cro are regulated by several strong promoters overlapping with the OR operators. The data suggest that Cro represses cB transcription but not its own synthesis, as already reported for PY54 Cro. Thus, not only PY54, but also phage ϕKO2 possesses a genetic switch that diverges significantly from the switch of lambda-like phages.
Smoking prevalence and knowledge of associated risks in adult attenders at day centres for people with learning disabilities.

BACKGROUND Increased longevity among people with learning disabilities is accompanied by an increase in morbidity. A possible explanation is that living in the community and a move to greater independence may bring higher health risks through obesity and smoking. The study aimed to see if rates of smoking have increased from earlier published rates and to ascertain the awareness of the risks of smoking among people with learning disabilities. METHODS A total of 435 people attending four social services day centres in a large urban area were assisted to complete a questionnaire. RESULTS Twenty-seven (6.2%) reported that they currently smoked. Those with mild disabilities were much more likely to smoke than those with more severe disabilities and they also reported smoking more heavily. For those with mild levels of learning disability, a higher than expected proportion living in hospital and staffed housing smoked, a lower proportion living with parents smoked but for those living independently the proportion who smoked was no higher than expected. Smokers were more knowledgeable about the risks than non-smokers even if the level of learning disability was controlled for. Only a third of smokers were concerned about the risks. CONCLUSIONS The study provides no evidence that rates of smoking are increasing among people with learning disabilities nor that those living independently were more likely to smoke. Knowledge of health risks is poor across the group, but higher among the smokers who were unlikely to express concern about the risks. This may indicate that more support may be needed along with health education in this group.
Limiting Long-Term Illness and Household Structure among People Aged 45 and over, Great Britain 1991

The aim of the study reported here was to investigate the relationship between health and household composition among older people. The 1 per cent and 2 per cent SARs (Samples of Anonymised Records) drawn from 1991 British Census data were used to examine the frequency of a limiting long-term illness among older people according to different types of living arrangements. These data include the population in institutions and our results show that previous studies based only on the private household population have underestimated the prevalence of illness among older people. Long-term illness rates vary across family and household types, with higher frequencies found for those individuals not living in families (either alone or with others) or in lone parent families, compared with those living as part of a couple. Importantly, our results show a previously unreported clustering of long-term illness in households. Those over 45 suffering from a limiting long-term illness were more likely than those without such an illness, to live in households including others with long-term illness. These results indicate that health should be considered from a household, rather than just an individual, perspective. Our findings support those who have argued that families including an older ill member need more help from formal services. However, it is unlikely that this can be achieved solely by redeploying services from those living alone as long-term illness rates were also high in this group.
Sparsity Constrained Nonlinear Optimization: Optimality Conditions and Algorithms

This paper treats the problem of minimizing a general continuously differentiable function subject to sparsity constraints. We present and analyze several different optimality criteria which are based on the notions of stationarity and coordinatewise optimality. These conditions are then used to derive three numerical algorithms aimed at finding points satisfying the resulting optimality criteria: the iterative hard thresholding method and the greedy and partial sparse-simplex methods. The first algorithm is essentially a gradient projection method, while the remaining two algorithms are of a coordinate descent type. The theoretical convergence of these techniques and their relations to the derived optimality conditions are studied. The algorithms and results are illustrated by several numerical examples.
TEMPORAL AND SPATIAL PARAMETERS OF GAIT IN CHILDREN. I: NORMAL CONTROL DATA

A study of the spatial and temporal parameters of gait was performed on 134 normal children, 68 boys and 66 girls, aged between three and 18 years. Normal gait showed a clear asymmetry; gait was considered to be abnormally asymmetrical if differences between left and right measurements exceeded 8 to 10 per cent. In addition, there was a definite bias corirparing left and right sides, which may relate to individual laterality.
The impact of body mass index on semen parameters in infertile men

This hospital‐based, prospective study was conducted to evaluate the relationship between body mass index (BMI) and various semen parameters in infertile men. A total of 439 men presented for infertility evaluation were assessed by basic infertility evaluation measures including semen analysis and BMI calculation. The main outcome measure was the relationship between BMI groups [BMI: 18.5–24.9 kg/m2 (normal weight), 25–29.9 kg/m2 (overweight) and ≥30 kg/m2 (obese)] and different semen parameters [volume, concentration, motility and morphology]. The mean BMI was 29.67 ± 5.89. Most of patients (82.91%) were overweight or obese. The 3 BMI groups were comparable in semen parameters (P > 0.05). BMI had a negative correlation with various semen parameters. However, this correlation was significant only with sperm concentration (P = 0.035). We concluded that sperm concentration was the only semen parameter which showed significant reduction with higher BMI in infertile men.
Zero Benefit

This study estimates the effect of zero tolerance disciplinary policies on racial disparities in school discipline in an urban district. Capitalizing on a natural experiment, the abrupt expansion of zero tolerance discipline policies in a mid-sized urban school district, the study demonstrates that Black students in the district were disproportionately affected, with an additional 70 Black students per year recommended for expulsion following the policy change. Furthermore, the study uses negative binomial regression discontinuity analysis to explore the effect of expanding zero tolerance on the proportion of days students are suspended. Following the policy change, the already sizeable difference in the proportion of days suspended between Black students and White students increased.
Social Learning as an Approach to Environmental Education: Lessons from a program focusing on non-indigenous, invasive species

We used a social learning framework to evaluate the results of an extension education program focusing on non-indigenous, invasive species (NIS) in New York State. Sixteen teams of professional staff and volunteers from Cornell Cooperative Extension (CCE), The Nature Conservancy (TNC), and a land trust participated in a 2-day NIS workshop, following which they worked with local government agencies, schools, industry, and non-profit groups to implement 15 education and 7 management programs. Developing collaborative programs that address local needs is an important aspect of social learning and learning communities in extension education. However, the program lacked other elements of social learning, e.g. educators evaluating and sharing the results of their local efforts. The potential for using social learning theory, which previously has been applied to sustainable agriculture and natural resources management, in environmental education may be viewed in light of motivating factors, benefits, and challenges for participants.
Silver Bullet or Voodoo Statistics?

Much of group and organization research is constrained by either limited sample sizes and/or nascent theoretical development. Wold developed the partial least squares (PLS) data analytical technique to help overcome these and other challenges facing researchers. PLS represents a powerful and effective means to test multivariate structural models with latent variables. Although PLS is used by researchers and practitioners in many scientific disciplines, some misunderstanding remains among group and organization researchers regarding the legitimacy and usefulness of PLS. To help allay these concerns, this article provides a nontechnical primer on PLS and its advantages, limitations, and application to group and organization research using a data set collected in an experiment on the effects of leadership styles and communication format on the group potency of computer-mediated work groups.
Long Complete Remission Achieved with the Combination Therapy of Cisplatin and Gemcitabine in a Patient with Aggressive Natural Killer Cell Leukemia

Aggressive natural killer cell leukemia (ANKL) is a rare and often lethal lymphoproliferative disorder. Patients may present with constitutional symptoms, jaundice, skin infiltration, lymphadenopathy, and hepatosplenomegaly. ANKL can progress quickly to multiorgan failure and survival is usually measured in weeks. Although a rapid and accurate diagnosis is critical, unfortunately there is no hallmark diagnostic marker of ANKL. We report a case of a 48-year-old male who was able to obtain a complete remission following cisplatin-based chemotherapy. We describe the details of the chemotherapy regimens used and a literature review of the treatment of ANKL.