Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary recommendations regarding pilot whale meat and blubber in the Faroe Islands

For centuries the pilot whale has been an important part Faroese life – both in regard to food and culture. However, studies dating back to 1977 have shown an increase in contamination of the meat, blubber, liver and kidneys of pilot whales. Several birth cohorts have been established in the Faroes in order to discover the health effects related to mercury and organchlorine exposure. In short the results have so far shown that: mercury from pilot whale meat adversely affects the foetal development of the nervous system; the mercury effect is still detectable during adolescence; the mercury from the maternal diet affects the blood pressure of the children; the contaminants of the blubber adversely affect the immune system so that the children react more poorly to immunizations; contaminants in pilot whales appear to increase the risk of developing Parkinson's disease in those who often eat pilot whale; the risk of hypertension and arteriosclerosis of the carotid arteries is increased in adults who have an increased exposure to mercury; septuagenarians with type 2 diabetes or impaired fasting glycaemia tended to have higher PCB concentrations and higher past intake of traditional foods, especially during childhood and adolescence. Also impaired insulin secretion appears to constitute an important part of the type 2 diabetes pathogenesis associated with exposure to persistent lipophilic food contaminants. From the latest research results, the authors consider that the conclusion from a human health perspective must be to recommend that pilot whale is no longer used for human consumption.
Modelling transition dynamics in MDPs with RKHS embeddings

We propose a new, nonparametric approach to learning and representing transition dynamics in Markov decision processes (MDPs), which can be combined easily with dynamic programming methods for policy optimisation and value estimation. This approach makes use of a recently developed representation of conditional distributions as embeddings in a reproducing kernel Hilbert space (RKHS). Such representations bypass the need for estimating transition probabilities or densities, and apply to any domain on which kernels can be defined. This avoids the need to calculate intractable integrals, since expectations are represented as RKHS inner products whose computation has linear complexity in the number of points used to represent the embedding. We provide guarantees for the proposed applications in MDPs: in the context of a value iteration algorithm, we prove convergence to either the optimal policy, or to the closest projection of the optimal policy in our model class (an RKHS), under reasonable assumptions. In experiments, we investigate a learning task in a typical classical control setting (the under-actuated pendulum), and on a navigation problem where only images from a sensor are observed. For policy optimisation we compare with least-squares policy iteration where a Gaussian process is used for value function estimation. For value estimation we also compare to the NPDP method. Our approach achieves better performance in all experiments.
Markers of Epithelial to Mesenchymal Transition in Association with Survival in Head and Neck Squamous Cell Carcinoma (HNSCC)

Background Elucidating the molecular phenotype of cancers with high metastatic potential will facilitate the development of novel therapeutic approaches to the disease. Gene expression profiles link epithelial to mesenchymal transition (EMT) phenotype with high-risk HNSCC. We sought to determine the role of protein biomarkers of EMT in head and neck squamous carcinoma (HNSC) prognosis. Methods Protein expression analysis of EGFR, β-catenin and E-cadherin was performed on a cohort of 102 patients with HNSCC recruited between 1992 and 2005 using automated quantitative protein analysis (AQUA). We evaluated associations with clinicopathological parameters and prognosis. Results There were 67 patients with primary squamous cell carcinoma of the head and neck in this cohort who met inclusion criteria and for whom we had complete E-cadherin, beta-catenin and EGFR expression data. High E-cadherin expressers had longer 5-year progression-free survival (PFS) compared to those with low E-cadherin (59.7% versus 40.6%, p = 0.04) and overall survival (OS) (69.6% versus 44.3%, p = 0.05). Kaplan-Meier analysis showed that patients with low beta-catenin-expressing tumors trended toward worse 5-year PFS (p = 0.057). High EGFR expressers had inferior OS compared to low EGFR expressers (27.7% vs. 54%, p = 0.029). In the multivariable analysis context, E-cadherin remained an independent predictor of improved OS (HR = 0.204, 95% CI 0.043 to 0.972, p = 0.046) while EGFR trended towards significance for OS. Conclusions The putative markers of EMT defined within a panel of HNSCC using AQUA are associated with tumors of poor prognosis.
Multimodal Compact Bilinear Pooling for Visual Question Answering and Visual Grounding

Modeling textual or visual information with vector representations trained from large language or visual datasets has been successfully explored in recent years. However, tasks such as visual question answering require combining these vector representations with each other. Approaches to multimodal pooling include element-wise product or sum, as well as concatenation of the visual and textual representations. We hypothesize that these methods are not as expressive as an outer product of the visual and textual vectors. As the outer product is typically infeasible due to its high dimensionality, we instead propose utilizing Multimodal Compact Bilinear pooling (MCB) to efficiently and expressively combine multimodal features. We extensively evaluate MCB on the visual question answering and grounding tasks. We consistently show the benefit of MCB over ablations without MCB. For visual question answering, we present an architecture which uses MCB twice, once for predicting attention over spatial features and again to combine the attended representation with the question representation. This model outperforms the state-of-the-art on the Visual7W dataset and the VQA challenge.
Adaptively secure multi-party computation

A fundamental problem in designing secure multi-party protocols is how to deal with adaptive adversaries (i.e., adversaries that may choose the corrupted parties during the course of the computation), in a setting where the channels are insecure and secure communication is achieved by cryptographic primitives based on computational limitations of the adversary. It turns out that the power of an adaptive adversary is greatly affected by the amount of information gathered upon the corruption of the party. This amount of information models the extent to which uncorrupted parties are trusted to carry out instructions that cannot be externally verified, such as erasing records of past configurations. It has been shown that if the parties are trusted to erase such records, then adaptivity secure computation can be carried out using known primitives. However, this total trust in parties may be unrealistic in many scenarios. An important question, open since 1986, is whether adaptively secure multi-party computation can be carried out in the "insecure channel" setting, even if no party is thoroughly trusted. Our main result is an affirmative resolution of this question for the case where even uncorrupted parties may deviate from the protocol by keeping record of all past configurations. We first propose a novel property of encryption protocols and show that if an encryption protocol enjoying this property is used, instead of a standard encryption scheme, then known constructions become adaptively secure. Next we constructed, based on standard RSA assumption, an encryption protocol that enjoys this property. We also consider parties that, even when corrupted, may internally deviate from their protocols in arbitrary ways, as long as no external test can detect faulty behavior. We show that in this case no non-trivial protocol can be proven adaptively secure using black-box simulation. This holds even if the communication channels are totally secure.
Combination of Decompressive Craniectomy and Mild Hypothermia Ameliorates Infarction Volume After Permanent Focal Ischemia in Rats

Background and Purpose— Both hypothermia and decompressive craniectomy (DC) have been shown to reduce ischemic injury in experimental middle cerebral artery (MCA) infarction. This study was designed to evaluate the effect of combined DC and hypothermia on infarction size and neurological outcome in a rat model of MCA occlusion (MCAO). Methods— MCAO was performed in 72 Wistar rats assigned to groups A through F. In group A, mild hypothermia (32°C) was induced 1 hour after MCAO for 5 hours; normothermia was maintained in group B. After 6 hours of survival, infarction size was calculated for animals of groups A and B. In group C, DC alone was performed 4 hours after MCAO; hypothermia without DC was performed 1 hour after MCAO and maintained for 5 hours in group D. Combined DC and hypothermia were performed in group E. No therapy was performed in group F (control). Infarction size and neurological performance after 24 hours were used as study end points (groups C through F). Results— Permanent postischemic hypothermia significantly reduced infarction size 6 hours after MCAO compared with controls (group A, 6.6±2.4%; group B, 20.2±2.6%;P <0.01). Twenty-four hours after MCAO, infarction size was not significantly reduced by hypothermia alone (group D, 21.9±3.6%). Compared with controls (group F, 23.3±3.3%), infarction size was significantly reduced and neurological performance was significantly improved in animals treated by DC (group C, 11.8±3.4;P <0.001). Combined hypothermia and DC resulted in additional reduction of infarction size (group E, 9.1±2.4%) and improved neurological score (P <0.01). Conclusions— Early DC significantly reduces infarction size and improves neurological outcome in MCA infarction in rats. Temporary mild hypothermia delays infarct evolution but does not significantly reduce definite infarction size or improve neurological outcome. Combined hypothermia and DC yield significant additional benefit.
Esaim: Control, Optimisation and Calculus of Variations Oscillations and Concentrations Generated by A-free Mappings and Weak Lower Semicontinuity of Integral Functionals

DiPerna's and Majda's generalization of Young measures is used to describe oscillations and concentrations in sequences of maps {u k } k∈N ⊂ L p (Ω; R m) satisfying a linear differential constraint Au k = 0. Applications to sequential weak lower semicontinuity of integral functionals on A-free sequences and to weak continuity of determinants are given. In particular, we state necessary and sufficient conditions for weak* convergence of det∇ϕ k * det∇ϕ in measures on the closure of Ω ⊂ R n if ϕ k ϕ in W 1,n (Ω; R n). This convergence holds, for example, under Dirichlet boundary conditions. Further, we formulate a Biting-like lemma precisely stating which subsets Ωj ⊂ Ω must be removed to obtain weak lower semicontinuity of u → Ω\Ω j v(u(x)) dx along {u k } ⊂ L p (Ω; R m)∩ker A. Specifically, Ωj are arbitrarily thin " boundary layers " .
An efficient integrated gender detection scheme and time mediated averaging of gender dependent acoustic models

This paper discusses building gender dependent gaussian mixture models (GMMs) and how to integrate these with an efﬁcient gender detection scheme. Gender speciﬁc acoustic models of half the size of a corresponding gender independent acoustic model substantially outperform the larger gender independent acoustic models. With perfect gender detection, gender dependent modeling should therefore yield higher recognition accuracy without consuming more memory. Furthermore, as certain phonemes are inherently gender independent (e.g. silence) much of the male and female speciﬁc acoustic models can be shared. This paper proposes how to discover which phonemes are inherently similar for male and female speakers and how to efﬁciently share this information between gender dependent GMMs. A highly accurate and computationally efﬁcient gender detection scheme is suggested that takes advantage of computations inherently done in the speech recognizer. By making the gender assignment probabilistic an increase in word error rate (WER) seen for erroneously gender labeled speakers is avoided. The method of gender detection and probabilistic use of gender is novel and should be of interest beyond mere gender detection. The only requirement for the method to work is that the training data be appropriately labeled.
Stroke in Young Adults in the Community-Based L’Aquila Registry: Incidence and Prognosis

Background and Purpose— Stroke type in the young may influence the outcome and may have a dramatic impact on the quality of life in survivors. This study aimed to evaluate the incidence and prognosis of first-ever stroke in the young and to make comparisons with older patients within a well-defined population. Methods— All first-ever strokes occurring in the L’Aquila district, central Italy, were traced by active monitoring of inpatient and outpatient health services. Incidence rates were standardized to the 1996 European population according to the direct method. Long-term survival was estimated by the Kaplan-Meier method; outcome in survivors was evaluated by the modified Rankin scale. Results— Of 4353 patients who had a first-ever stroke, 89 patients <45 years of age (55 men and 34 women) (2%) were identified in a 5-year period. Mean age±SD was 36.1±8.1 years. Twenty patients (22.5%) had a subarachnoid hemorrhage, 18 (20.2%) an intracerebral hemorrhage, and 51 (57.3%) a cerebral infarction. The corresponding proportions in patients >45 years of age were 2.4%, 13.3%, and 83.1%. Neuroimaging studies of the brain detected 14 intracranial aneurysms and 6 arteriovenous malformations in 20 of 38 patients (52.6%) with either subarachnoid (n=17) or intracerebral (n=3) hemorrhage. The crude annual incidence rate was 10.18/100 000 (95% CI, 8.14 to 12.57) and 10.23/100 000 when standardized to the 1996 European population. The 30-day case-fatality rate was 11.2% (95% CI, 6.2 to 19.4). Patients with subarachnoid hemorrhage had the highest proportion of good recovery (60%), patients with intracerebral hemorrhage had the highest mortality (44%), and patients with cerebral infarction had the highest proportion of severe disability (47%). Conclusions— Stroke patients <45 years of age showed a disproportionate cumulative high prevalence (42.7%) of subarachnoid and intracerebral hemorrhage with respect to older patients (15.7%), mainly (52.6%) due to aneurysms and arteriovenous malformations. Therefore, screening procedures and preventive strategies in the young should also be addressed to subjects at risk of subarachnoid and intracerebral hemorrhage.
Comparisons of late vaginal mucosal reactions between interstitial and conventional intracavitary brachytherapy in patients with gynecological cancer: speculation on the relation between pallor reaction and stenosis.

BACKGROUND/AIM To examine late vaginal mucosal reactions in patients following interstitial brachytherapy (ISBT) compared with that of intracavitary brachytherapy (ICBT). PATIENTS AND METHODS We introduced a modified Dische score to examine late reactions in vaginal mucosa of patients with gynecological cancer who underwent vaginal brachytherapy at 6, 12, 18, 24, 36, and 60 months after treatment. A comparison was made between patients who underwent ISBT (n=37) and those under conventional ICBT (n=63) with a median follow-up time of 41 months. The ICBT group included only patients with newly diagnosed cervical cancer, whereas the ISBT group included 17 patients with recurrent and 20 with newly-diagnosed cancer. RESULTS Grade 1 reactions of bleeding and discharge were exhibited by <12% of patients. Erythema was detected in approximately 30% (mainly grade 1) of the patients. A total of two (3%) patients developed superficial ulceration after ICBT, whereas three (8%) grade 1 ulcers were detected in patients after ISBT. Telangiectasias were detected in approximately 70% (60% grade 1 and 10% grade 2) of patients. No statistically significant difference was found between the patients after ISBT and ICBT. After ISBT, patients have a higher stenosis rate than after ICBT (p=0.003). The pallor scores showed a strong correlation with stenosis (p<0.0001) and were higher in patients after ICBT than in patients after ISBT (p=0.006). CONCLUSION After ISBT, patients exhibited milder but similar late mucosal reactions compared to those after ICBT, except the fact that the stenosis was more severe and the pallor reaction was milder in these patients. It can be, therefore, concluded that the pallor reaction is related to stenosis.
Contact resistance and megahertz operation of aggressively scaled organic transistors.

Bottom-gate, top-contact organic thin-film transistors (TFTs) with excellent static characteristics (on/off ratio: 10(7) ; intrinsic mobility: 3 cm(2) (V s)(-1) ) and fast unipolar ring oscillators (signal delay as short as 230 ns per stage) are fabricated. The significant contribution of the transfer length to the relation between channel length, contact length, contact resistance, effective mobility, and cutoff frequency of the TFTs is theoretically and experimentally analyzed.
Metallothionein in bovine spongiform encephalopathy.

An increase in metallothionein I and II (MT I/II) mRNA concentrations has been reported in the central nervous system of scrapie-infected rodents. In this study we compared cattle with bovine spongiform encephalopathy (BSE), cattle affected by neurological disease other than BSE, and clinically healthy cattle in respect of MT I/II immunoreactivity in brainstem medullary tissue. Marked astrocytic MT I/II immunolabelling was seen in all BSE-affected animals, in contrast to clinically healthy cases, in which no such labelling was detected. In BSE, MT I/II immunoreactive astrocytes were confined specifically to areas of vacuolation or abnormal prion protein (PrP(BSE)) deposition, or both. MT I/II immunolabelling was also seen in a small number of animals with a neurological disease other than BSE. These findings complement previous studies by demonstrating increased levels of MT I/II in transmissible spongiform encephalopathy (TSE)-infected brain tissue, indicating that MT I/II may play some as yet unidentified role in the response to TSE infection.
Reconfigurable computing: architectures and design methods

Reconfigurable computing is becoming increasingly attractive for many applications. This survey covers two aspects of reconfigurable computing: architectures and design methods. The paper includes recent advances in reconfigurable architectures, such as the Alters Stratix II and Xilinx Virtex 4 FPGA devices. The authors identify major trends in general-purpose and special-purpose design methods. It is shown that reconfigurable computing designs are capable of achieving up to 500 times speedup and 70% energy savings over microprocessor implementations for specific applications.
Quorum Sensing Activity of a Kluyvera sp. Isolated from a Malaysian Waterfall

In many species of bacteria, the quorum sensing mechanism is used as a unique communication system which allows them to regulate gene expression and behavior in accordance with their population density. N-Acylhomoserine lactones (AHLs) are known as diffusible autoinducer molecules involved in this communication network. This finding aimed to characterize the production of AHL of a bacterial strain ND04 isolated from a Malaysian waterfall. Strain ND04 was identified as Kluyvera sp. as confirmed by molecular analysis of its 16S ribosomal RNA gene sequence. Kluyvera sp. is closely related to the Enterobacteriaceae family. Chromobacterium violaceum CV026 was used as a biosensor to detect the production of AHL by strain ND04. High resolution triple quadrupole liquid chromatography-mass spectrometry analysis of strain ND04 showed our isolate produced two AHLs which are N-(3-oxohexanoyl)homoserine lactone (3-oxo-C6 HSL) and N-3-oxo-octanoyl-L-homoserine lactone (3-oxo-C8 HSL).
Chills As an Indicator of Individual Emotional Peaks

Chills (goose bumps) have been repeatedly associated with positive emotional peaks. Chills seem to be related to distinct musical structures and the reward system in the brain. A new approach that uses chills as indicators of individual emotional peaks is discussed. Chill reactions of 95 participants in response to seven music pieces were recorded. Subjective intensity as well as physiological arousal (skin conductance response, heart rate) revealed peaks during chill episodes. This review suggests that chills are a reliable indicator of individual emotional peaks, combining reports of subjective feelings with physiological arousal.
Elevation of plasma granzyme B levels after acute myocardial infarction.

BACKGROUND Apoptosis is reported to play an important role in left ventricular (LV) remodeling after acute myocardial infarction (AMI). Granzyme B is a member of the serine esterase family, which has an important role in cellular apoptosis and extracellular matrix degradation. METHODS AND RESULTS Peripheral blood samples were obtained from 33 patients with a first-onset AMI treated by percutaneous coronary intervention (mean age: 61.4+/-8.7 years old) on days 1, 7 and 14 after onset. Plasma levels of tumor necrosis factor (TNF)-alpha, a soluble form of the Fas ligand (sFasL), and granzyme B were measured. TIMI grade 3 recanalization was accomplished in all patients within 12 h after onset. The LV end-diastolic volume index (LVEDVI) was calculated on day 1 and at 6 months after onset. Plasma levels of TNF-alpha, sFasL and granzyme B increased significantly on days 7 and 14 after onset of AMI. Stepwise multivariate regression analysis showed that the plasma granzyme B level on day 14 is a significant explanatory variable for changes in the LVEDVI. CONCLUSIONS Plasma levels of granzyme B increased after AMI, which might be an important factor in the progression of late LV remodeling after AMI.
Controversial Psychological Research Methods and Their Influence on the Development of Formal Ethical Guidelines

Presently, researchers must give special ethical concerns to monitor participant treatment when they are utilizing controversial research methods. Such methods include, but are not limited to deception, coercion, and potentially inducing psychological harm. Throughout the course of the history of psychology as a science, a number of different ethical guidelines have been developed and employed in a variety of ways. The interest in developing guidelines for psychological research was stimulated by several studies, particularly Watson and Raynor's research on Little Albert (1920), Milgram's interest in obedience (1963; 1964), Humphrey's naturalistic observations of tearooms (1973), and Zimbardo and colleague's prison experiment (1973). Each of these studies has in part contributed to the current ethical standards for psychology research on humans in the United States. Current APA guidelines are briefly discussed.