Miracle-dz/UniFAR-FTUs huggingface dataset:
Wavelength conversion architectures in OBS networks

Most studies about Optical Burst Switched (OBS) networks have assumed availability of full wavelength conversion throughout the network. In an optical network with full wavelength conversion capability, every output on each node is provided with a wavelength converter, resulting in the lowest bound for blocking probability. However, full wavelength conversion capability requires a large number of wavelength converters, which is, and will remain, quite expensive in the foreseeable future. Therefore, it is expected that conversion capability will be limited and only sparsely deployed. In this work we apply to OBS networks the main architectures for wavelength conversion proposed for circuit switched networks. These architectures operate with limited wavelength conversion capability. We also investigate the cost benefit and the gain factor related to full complete wavelength conversion for each architecture. In addition, we propose a new methodology to define the number of wavelength converters in order to achieve the best cost benefit, regardless of the traffic load.
Measuring and Comparing Individuals and Events

This squib investigates parallels between nominal and verbal comparatives. Building on key insights of Hackl (2000) and Bale & Barner (2009), we show that more behaves uniformly when it combines with nominal and verbal predicates: (i) it cannot combine with singular count NPs or perfective telic VPs; (ii) grammatical properties of the predicates determine the scale of comparison—plural marked NPs and habitual VPs are compared on a scale of cardinality, whereas mass NPs and perfective (atelic) VPs are (often) compared along non-cardinal, though monotonic, scales. Taken together, our findings confirm and strengthen parallels that have independently been drawn between the nominal and verbal domains. In addition, our discussion and data, drawn from English, Spanish, and Bulgarian, suggest that the semantic contribution of more can be given a uniform analysis.
Long Term Results of PHILOS Plating and Percutaneous K-Wire Fixation in Proximal Humerus Fractures in The Elderly

Abstract This is a report of a study on the long term results of PHILOS plating and percutaneous K-wire fixation in a prospective series of proximal humerus fractures in elderly patients. We reviewed a total of 60 patients with proximal humerus fractures in 30 patients (Group 1), who were treated by open reduction and internal fixation with Proximal Humeral Internal Locking System (PHILOS) plate and 30 patients (Group 2) who were treated with percutaneous K-wire fixation. Functional outcome was assessed using Visual Analogue Scale(VAS) and Constant-Murley Score. Mean Constant-Murley score was 84.6 points (range: 61- 100) in Group 1 and - 76.4 points(range:56-100) in Group 2 at final follow up. Values varied depending upon the fracture type with worst in 4-part fractures. Mean VAS Score was 2.6(range:0-10) in Group 1 and 3.8(range:0-10) in Group 2. We obtained satisfactory results in both the groups, with each procedure having its advantages and shortcomings. We found that PHILOS plate fixation provided stable fixation with minimal implant problems and enabled early range-ofmotion exercises to achieve acceptable functional results. Fixation with percutaneous K-wires presented an efficient treatment option with the advantages of minimal invasiveness and soft tissue dissection. Key Words Proximal humerus fractures, PHILOS plate and K-wires
Expression Pattern of Osteopontin in Endometrial Carcinoma: Correlation With Expression of the Adhesion Molecule CEACAM1

Summary: Osteopontin (OPN) and CEACAM1 have diverse biological functions in the uterus and placenta throughout the estrous cycle and pregnancy and have been shown to interact with integrin &bgr;3. OPN is a glycoprotein of the extracellular matrix, which has been shown to mediate cellular migration and invasion and to contribute to tumorigenesis in several types of cancers. Recently we showed the expression pattern of OPN in gestational trophoblastic tumors. CEACAM1 is an adhesion molecule of the carcinoembryonic antigen family that we have recently found to be expressed in endometrial cancer and that has been shown to be down-regulated in colorectal, prostate, and breast cancer. In this study, immunohistochemistry and immunofluorescence with specific antibodies were performed on a series of 20 normal endometrial samples, 17 endometrial hyperplasias, and 43 endometrial carcinomas (28 endometrioid, 10 serous, and 5 clear cell carcinomas) to investigate the expression pattern and cell-type specific localization of OPN and to correlate it with the expression of CEACAM1. In addition, Western blot was performed on normal human endometrium and endometrial neoplasia. Strong OPN expression with a consistent cytoplasmic localization in epithelial glandular cells was observed in the normal human endometrium in 80% of the samples of the proliferative and secretory phase (score 8-12). Similar results could be found in endometrial hyperplasias. Strong expression of OPN could be observed in 29 (67.4%) of the 43 analyzed endometrial carcinomas. Of the 43 analyzed tumors, 18 (41.8%) were in the high score (8-12) category with a strong OPN expression level; 11 of 43 (25.5%) showed a moderate score (4-7) category. In endometrioid carcinoma with increasing malignancy grade, increasing areas with low OPN expression level or complete loss of OPN expression could be observed. In contrast, serous tumors showed a strong OPN expression level. Similar results could be found in Western blot analysis. CEACAM1 showed similar results and could be found to be coexpressed with OPN in normal human endometrium and in endometrial neoplasia as we showed using immunofluorescence. In this study, the different expression patterns of OPN in endometrial tumors could additionally support the biological diversity of endometrioid and serous carcinomas together with other markers. We suggest that OPN might play a different role in the pathogenesis of endometrial cancer (possibly as a functional complex with CEACAM1) and could be relevant for invasive growth of such lesions.
SOCIAL EVOLUTION IN ANTS: DIRECT AND INDIRECT GENETIC EFFECTS

v Chapter 1: The evolutionary origin and elaboration of eusociality: maternal effects, sibsocial effects, and heterochrony . 1 Chapter 2: The evolutionary importance of direct, maternal, and sibsocial genetic effects on mass, caste ratio, and sex ratio in an acorn ant . 61 Chapter 3: Experimental study of colony resource allocation: effects of queen removal and relatedness between workers and larvae in the ant Temnothorax curvispinosus . 112 Chapter 4: The direct and indirect genetic basis of phenotypic differences among ant species . 152 Curriculum Vitae . 175
The Role of Planning in the Development of Shenzhen, China: Rhetoric and Realities

This paper examines the role played by socioeconomic and spatial planning in the development of China's first special economic zone (SEZ), Shenzhen. More specifically, it analyzes the impacts of socioeconomic five- and ten-year plans and Master Layout Plans in Shenzhen's metamorphosis from an industry-based SEZ relying on domestic investment (early 1980s) to a modern metropolis sustained by an export-oriented economy. The authors explore the tension between local officials' aspirations to make Shenzen a 21st century "world city" and the dual obstacles of policy control by the central government and the need to harness local development within Shenzhen. Journal of Economic Literature, Classification Numbers: H70, O18, O20. 2 figures, 4 tables, 67 references.
Recent results on the helicity structure of the nucleon from HERMES

The HERMES experiment has measured double spin asymmetries of inclusive and semi-inclusive cross sections for the production of charged hadrons in deep-inelastic scattering of polarised positrons on polarised hydrogen and deuterium targets, in the kinematic range 0.023 < x < 0.6, and 1 GeV^2 < Q^2 < 15 GeV^2. For the data taken on the deuterium target, a RICH detector provides the complete identification of charged pions and kaons. From the inclusive measurements on deuterium, the polarised structure function g_1^d has been extracted with high precision. Together with the semi-inclusive measurements, quark polarisations are extracted separately for the u, ubar, d, dbar, and (s + sbar) flavours in a LO QCD analysis. Furthermore, a possible breaking of flavour symmetry in the polarised light sea, (Delta ubar - Delta dbar), was measured for the first time and found to be consistent with zero within the experimental precision.
Role of the salt-bridge between switch-1 and switch-2 of Dictyostelium myosin.

Motifs N2 and N3, also referred to as switch-1 and switch-2, form part of the active site of molecular motors such as myosins and kinesins. In the case of myosin, N3 is thought to act as a gamma-phosphate sensor and moves almost 6 A relative to N2 during the catalysed turnover of ATP, opening and closing the active site surrounding the gamma-phosphate. The closed form seems to be necessary for hydrolysis and is stabilised by the formation of a salt-bridge between an arginine residue in N2 and a glutamate residue in N3. We examined the role of this salt-bridge in Dictyostelium discoideum myosin. Myosin motor domains with mutations E459R or R238E, that block salt-bridge formation, show defects in nucleotide-binding, reduced rates of ATP hydrolysis and a tenfold reduction in actin affinity. Inversion of the salt-bridge in double-mutant M765-IS eliminates most of the defects observed for the single mutants. With the exception of a 2,500-fold higher KMvalue for ATP, the double-mutant displayed enzymatic and functional properties very similar to those of the wild-type protein. Our results reveal that, independent of its orientation, the salt-bridge is required to support efficient ATP hydrolysis, normal communication between different functional regions of the myosin head, and motor function.
Clofarabine: emerging role in leukemias

Clofarabine is a second-generation purine nucleoside analogue. It works mainly by inhibiting ribonucleotide reductase and incorporating into DNA. Clofarabine has shown efficacy in selected pediatric leukemias. It has also shown significant efficacy alone and in combination with other drugs in treating adult myeloid leukemias and high-risk myelodysplastic syndromes. Further, there is significant promise for clofarabine in the treatment of older patients with acute myeloid leukemia who are unlikely to benefit from standard induction chemotherapy due to unfavorable baseline prognostic factors. An oral formulation of clofarabine is also currently under development.
Démocratisation scolaire, politiques éducatives et inégalités : une évaluation économique

Cette these evalue l'impact economique de trois des principales politiques educatives qui ont accompagne la democratisation de l'ecole en France: l'allongement de l'obligation scolaire, la sectorisation des etablissements scolaires et l'orientation des eleves. L'objectif de ce travail est de mesurer sur donnees francaises les consequences de ces politiques sur les inegalites educatives, entendues au sens large: inegalites economiques, inegalites socio-spatiales et inegalites liees a la date de naissance des individus. Nous commencons par analyser l'impact de la reforme Berthoin, qui porta en 1967 l'obligation scolaire de 14 a 16 ans revolus, sur le destin scolaire et professionnel des generations concernees et comparons ses effets a ceux de l'Education Act de 1973 qui porta au Royaume-Uni l'âge de fin d'etudes minimum de 15 a 16 ans. Nous proposons ensuite une analyse theorique et empirique du lien unissant politiques de sectorisation, stratification residentielle et inegalites scolaires: dans un premier temps, nous developpons un modele theorique destine a evaluer les proprietes de modalites alternatives d'allocation des eleves aux etablissements scolaires (sectorisation stricte, redecoupage de la carte scolaire ou libre choix de son ecole) avant de mesurer dans un second temps l'impact de la performance des colleges publics et prives sur le prix des logements a Paris. Nous terminons cette these par une evaluation systematique des consequences du mois de naissance des individus sur leurs trajectoires scolaires et professionnelles.
Efficiency of treatments for controlling Trichoderma spp during spawning in cultivation of lignicolous mushrooms

Trichoderma spp is the cause of the green mold disease in mushroom cultivation production. Many disinfection treatments are commonly applied to lignocellulose substrates to prevent contamination. Mushroom growers are usually worried about the contaminations that may occur after these treatments during handling or spawning. The aim of this paper is to estimate the growth of the green mold Trichoderma sp on lignocellulose substrates after different disinfection treatments to know which of them is more effective to avoid contamination during spawning phase. Three different treatments were assayed: sterilization (121 °C), immersion in hot water (60 and 80 °C), and immersion in alkalinized water. Wheat straw, wheat seeds and Eucalyptus or Populus sawdust were used separately as substrates. After the disinfection treatments, bagged substrates were sprayed with 3 mL of suspension of conidia of Trichoderma sp (105 conidia/mL) and then separately spawned with Pleurotus ostreatus or Gymnopilus pampeanus. The growth of Trichoderma sp was evaluated based on a qualitative scale. Trichoderma sp could not grow on non-sterilized substrates. Immersions in hot water treatments and immersion in alkalinized water were also unfavorable treatments for its growth. Co- cultivation with mushrooms favored Trichoderma sp growth. Mushroom cultivation disinfection treatments of lignocellulose substrates influence on the growth of Trichoderma sp when contaminations occur during spawning phase. The immersion in hot water at 60 °C for 30 min or in alkalinized water for 36 h, are treatments which better reduced the contaminations with Trichoderma sp during spawning phase for the cultivation of lignicolous species.
ASIC manufacturing test cost prediction at early design stage

This paper proposes a rest cost prediction model which estimates the cost of lC testing in a manufacturing environment. The model predicts chip testing cost and quality of test using a set of circuit manufacturing parameters. The objective is to use these circuit parameters which are available at the early stage of the design cycle to determine and optimize manufacturing test cost.
The Effect of Metformin on Diastolic Function in Patients Presenting with ST-Elevation Myocardial Infarction

Introduction Diastolic dysfunction is an important predictor of poor outcome after myocardial infarction. Metformin treatment improved diastolic function in animal models and patients with diabetes. Whether metformin improves diastolic function in patients presenting with ST-segment elevation myocardial infarction (STEMI) is unknown. Methods The GIPS-III trial randomized STEMI patients, without known diabetes, to metformin or placebo initiated directly after PCI. The previously reported primary endpoint was left ventricular ejection fraction at 4 months, which was unaffected by metformin treatment. This is a predefined substudy to determine an effect of metformin on diastolic function. For this substudy trans-thoracic echocardiography was performed during hospitalization and after 4 months. Diastolic dysfunction was defined as having the combination of a functional alteration (i.e. decreased tissue velocity: mean of septal e’ and lateral e’) and a structural alteration (i.e. increased left atrial volume index (LAVI)). In addition, left ventricular mass index and transmitral flow velocity (E) to mean e' ratio (E/e’) were measured to determine an effect of metformin on individual echocardiographic markers of diastolic function. Results In 237 (63%) patients included in the GIPS-III trial diastolic function was measured during hospitalization as well as at 4 months. Diastolic dysfunction was present in 11 (9%) of patients on metformin and 11 (9%) patients on placebo treatment (P = 0.98) during hospitalization. After 4 months 22 (19%) of patients with metformin and 18 (15%) patients with placebo (P = 0.47) had diastolic dysfunction. In addition, metformin did not improve any of the individual echocardiographic markers of diastolic function. Conclusions In contrast to experimental and observational data, our randomized placebo controlled trial did not suggest a beneficial effect of short-term metformin treatment on diastolic function in STEMI patients.
H2O Maser Observations of Candidate Post-AGB Stars and Discovery of Three High-Velocity Water Sources

We present the results of 22 GHz H2O maser observations of a sample of 85 post-asymptotic giant branch (post-AGB) candidate stars, selected on the basis of their OH 1612 MHz maser and far-infrared properties. All sources were observed with the Tidbinbilla 70 m radio telescope, and 21 detections were made; 86 GHz SiO Mopra observations of a subset of the sample are also presented. Of the 21 H2O detections, 15 are from sources that are likely to be massive AGB stars and most of these show typical, regular H2O maser profiles. In contrast, nearly all the detections of more evolved stars exhibited high-velocity H2O maser emission. Of the five sources seen, v223 (W43A, IRAS 18450-0148) is a well-known "water-fountain" source that belongs to a small group of post-AGB stars with highly collimated, high-velocity H2O maser emission. A second source in our sample, v270 (IRAS 18596+0315), is also known to have high-velocity emission. We report the discovery of similar emission from a further three sources, d46 (IRAS 15445-5449), d62 (IRAS 15544-5332), and b292 (IRAS 18043-2116). The source d46 is an evolved post-AGB star with highly unusual maser properties. The H2O maser emission from d62 is probably associated with a massive star. The source b292 is a young post-AGB star that is highly likely to be a water-fountain source, with masers detected over a velocity range of 210 km s-1.
Danish Register of chronic obstructive pulmonary disease

Aim of database The Danish Register of Chronic Obstructive Pulmonary Disease (DrCOPD) is a nationwide database aiming to describe the quality of treatment of all patients with chronic obstructive pulmonary disease (COPD) in Denmark. Study population DrCOPD comprises data on all patients with a diagnosis of COPD. In the hospital setting, both in- and outpatients are included. In the setting of the general practice (GP), DrCOPD aims to include all patients with a COPD diagnosis who attend an annual control visit for COPD. Main variables DrCOPD includes information on forced expiratory volume in 1 second, smoking status, body mass index, dyspnea, treatment modalities such as rehabilitation, smoking cessation, medical treatment, and the use of noninvasive ventilation during hospitalization due to exacerbations. The outcome variables include frequency of readmission and death 30 days after discharge from hospital. Descriptive data Since 2008, the registration in the Danish hospitals has gradually become more comprehensive. In 2014, ~90% of 16,106 eligible patients had complete data sets that showed an improvement in the processes describing quality of care, including increased offering of smoking cessation, rehabilitation, and correct treatment with inhaled medication. Data from GPs have been included since 2011, but are still incomplete and comprise only ~20% of all COPD patients seen. The collection of data from GP settings has recently been hampered due to legislative controversies. Conclusion In relatively few years, DrCOPD has become increasingly comprehensive and has documented an improvement in the management of COPD in Danish hospitals.
Effects of Off-Pump Versus On-Pump Coronary Surgery on Reversible and Irreversible Myocardial Injury: A Randomized Trial Using Cardiovascular Magnetic Resonance Imaging and Biochemical Markers

Background—There is biochemical evidence that off-pump coronary artery bypass grafting (OPCABG) reduces myocardial injury compared with the use of cardiopulmonary bypass (ONCABG), but the functional significance of this is uncertain. We hypothesized that OPCABG surgery would result in reduced postoperative reversible (stunning) and irreversible myocardial injury, as assessed by cardiovascular MRI (CMRI). Methods and Results—In a single-center randomized trial, 60 patients undergoing multivessel total arterial revascularization were randomly assigned: 30 to OPCABG and 30 to ONCABG. Patients underwent preoperative and early postoperative cine MRI for assessment of global left ventricular function, and contrast-enhanced CMRI for assessment of irreversible myocardial injury. Serial troponin I measurements were obtained perioperatively and correlated with the CMRI findings. The mean preoperative cardiac index was similar in the 2 surgical groups (2.9±0.7 ONCABG; 2.9±0.8 OPCABG; P =0.9). After surgery, the cardiac index was significantly higher in the OPCABG group (2.7±0.6 ONCABG; 3.2±0.8 OPCABG; P =0.04). New irreversible myocardial injury was similar in incidence (36% ONCABG; 44% OPCABG; P =0.8) and magnitude (6.3±3.6 g ONCABG; 6.8±4.0 g OPCABG; P =0.9) across the 2 groups. The median area-under-the-curve (AUC) troponin I values were significantly larger in the ONCABG group (182 versus 135 &mgr;g/L; P =0.02). There was a moderate correlation between the troponin I AUC values and mean mass of new myocardial hyperenhancement (r2=0.4; P =0.008). Conclusions—OPCABG results in significantly better left ventricular function early after surgery but does not reduce the incidence or extent of irreversible myocardial injury.
Risk factors and risk for mortality of mild hypoparathyroidism in hemodialysis patients.

Relative hypoparathyroidism (parathyroid hormone [PTH] < or = 200 pg/mL) is prevalent in hemodialysis (HD) patients, with unknown pathogenesis and prognosis. Thus, to clarify risk factors and prognosis of time-dependent relative hypoparathyroidism in HD patients, a retrospective cohort study was performed for 126 HD patients with four or more PTH determinations and no previous total or subtotal parathyroidectomy. Values for intact PTH, ionized calcium, phosphate, magnesium, albumin, creatinine, urea reduction ratio (URR), glucose, hemoglobin A1c (HbA1c), aluminum, and 1,25(OH)2D were obtained at enrollment and at some time during follow-up. The prevalence of relative hypoparathyroidism at entry was 76 of 126 patients (60.3%). Univariate analysis showed that patients with hypoparathyroidism were older, more likely to have diabetes, and had greater ionized calcium levels and lower phosphate, albumin, blood urea nitrogen (BUN), and creatinine levels. Patients with diabetes were older and had a shorter duration of dialysis therapy and lower PTH, phosphate, albumin, BUN, and creatinine levels and URRs. Conversely, multivariate analysis showed that PTH levels at entry were associated directly with creatinine levels and inversely with age and ionized calcium levels (but not diabetes). During follow-up, PTH levels fluctuated concomitantly with ionized calcium and phosphate levels over time in all patients. Time-dependent PTH levels were associated directly with duration of dialysis therapy and use of vitamin D and phosphate and albumin levels, but inversely with age and ionized calcium and magnesium levels (but not glucose or HbA1c levels). Interestingly, time-dependent PTH levels were independently associated with survival after adjusting for traditional risk factors (diabetes, age, albumin and creatinine levels, and URR) and duration of dialysis therapy. We conclude that in HD patients, relative hypoparathyroidism was not associated with diabetes per se. Time-dependent PTH levels were associated with age, duration of dialysis, and levels of ionized calcium, phosphate, albumin, and magnesium. Moreover, relative hypoparathyroidism at entry and lower time-dependent PTH levels predict mortality.