Miracle-dz/UniFAR-FTUs huggingface dataset:
Conscientiousness and adherence to the oral contraceptive pill: A prospective study

Objective: We assess the association between conscientiousness and adherence to the oral contraceptive pill (OCP), and examine if such a relationship is independent of a measure of prospective memory and a range of social cognitive variables. Method: Data were collected from 150 OCP users at baseline, and 99 provided follow-up data four weeks later. Conscientiousness, a range of social cognitive predictors and prospective memory were assessed at baseline. OCP adherence was measured at baseline, and again at Time 2. Data were analysed using correlation and multiple linear regression. Results: Higher conscientiousness was associated with higher overall OCP adherence in both cross-sectional (r = −0.28, p < 0.01) and prospective analysis (r = −0.34, p < 0.01). Conscientiousness predicted OCP adherence at Time 2, adjusting for OCP adherence at Time 1 (R2 change = 0.02, p = 0.04). The association was reduced to non-significance when social cognitive predictors and prospective memory were included in the multivariable model. Prospective memory was an independent predictor of OCP adherence at Time 2. Discussion: This is the first study to identify an association between conscientiousness and OCP adherence. The association is not independent from social cognitive predictors and prospective memory. Facet-level analysis of conscientiousness and formal mediation analyses are recommended in future replications.
Motion in the unstable cervical spine: comparison of manual turning and use of the Jackson table in prone positioning.

OBJECT The purpose of this study was to compare manual maneuvering with the use of a Jackson table when moving patients with cervical spine instability from the supine to the surgically appropriate prone position. METHODS The range of motion (ROM) of the cervical spine of a fresh cadaver was measured. A ligamentous instability was created at the C5-6 level, and the increased ROM was confirmed. Sensors for an electromagnetic motion analysis device were fixed to the anterior portions of the C-5 and C-6 vertebral bodies (VBs) using machined polyethylene mounts and carbon fiber rods that were inserted into the VBs. The sensors were used to measure cervical flexion, lateral bending, and axial rotation during the two transfer procedures. The cadaver was then moved from the supine position on a hospital bed to the prone position for surgery. The manual technique was performed by four trained individuals who moved the cadaver from the hospital bed while rotating it 180 degrees axially onto the surgical table. In using the Jackson table, the cadaver was moved from the bed to the table in the supine position and then the Jackson table rotated the cadaver to the prone position. The two techniques were tested with and without the use of a collar and were repeated five times. RESULTS Analysis of the data indicated that when moving a patient into the prone surgical position, the use of a cervical collar and the Jackson table significantly reduced the cervical motion in all angular planes compared with that of manual transfer. CONCLUSIONS The use of a cervical collar and the Jackson table may reduce the possibility of further spinal cord compromise. Because manual transfers are performed routinely, this warrants further study.
THE PRODUCTION OF RUNT DISEASE IN RATS THYMECTOMIZED AT BIRTH

Thymectomy of Sprague-Dawley rats on the 3rd day of life failed to influence the time of onset, incidence, clinical, or histologic picture of runt disease produced by the intraperitoneal injection of adult Long-Evans spleen cells. The fact that severe immunologic impairment of the host by thymectomy does not modify runt disease was felt to be consistent with the current view that the if direction of the immunologic event in this syndrome is graft versus host. Following the injection of 800 to 1000 million Long-Evans spleen cells into adult Sprague-Dawley rats, a severe illness comprised of dermatitis, gastrointestinal bleeding, arthritis, weight loss, and death ensued in 37 per cent of adults thymectomized neonatally and 13 per cent of normal controls. Histologic lesions were observed in 69 per cent of adequately thymectomized animals and 17 per cent of normal controls, and involved lymph nodes, spleen, liver, lungs, kidneys, joints, heart, and skin. The time of onset and the histologic and clinical pictures are consistent with the adult disease being a typical graft versus host reaction.
Unexpected Phenotype of Mice Lacking Shcbp1, a Protein Induced during T Cell Proliferation

T cell development and activation are highly regulated processes, and their proper execution is important for a competent immune system. Shc SH2-domain binding protein-1 (Shcbp1) is an evolutionarily conserved protein that binds to the adaptor protein ShcA. Studies in Drosophila and in cell lines have strongly linked Shcbp1 to cell proliferation, embryonic development, growth factor signaling, and tumorigenesis. Here we show that Shcbp1 expression is strikingly upregulated during the β-selection checkpoint in thymocytes, and that its expression tightly correlates with proliferative stages of T cell development. To evaluate the role for Shcbp1 during thymic selection and T cell function in vivo, we generated mice with global and conditional deletion of Shcbp1. Surprisingly, the loss of Shcbp1 expression did not have an obvious effect during T cell development. However, in a mouse model of experimental autoimmune encephalomyelitis (EAE), which depends on CD4+ T cell function and mimics multiple features of the human disease multiple sclerosis, Shcbp1 deficient mice had reduced disease severity and improved survival, and this effect was T cell intrinsic. These data suggest that despite the striking upregulation of Shcbp1 during T cell proliferation, loss of Shcbp1 does not directly affect T cell development, but regulates CD4+ T cell effector function in vivo.
Male mate choice influences female promiscuity in Soay sheep

In most animal species, males are predicted to compete for reproductive opportunities, while females are expected to choose between potential mates. However, when males' rate of reproduction is constrained, or females vary widely in ‘quality’, male mate choice is also predicted to occur. Such conditions exist in the promiscuous mating system of feral Soay sheep on St Kilda, Scotland, where a highly synchronized mating season, intense sperm competition and limitations on sperm production constrain males' potential reproductive rate, and females vary substantially in their ability to produce successful offspring. We show that, consistent with predictions, competitive rams focus their mating activity and siring success towards heavier females with higher inclusive fitness. To our knowledge, this is the first time that male mate choice has been identified and shown to lead to assortative patterns of parentage in a natural mammalian system, and occurs despite fierce male–male competition for mates. An additional consequence of assortative mating in this population is that lighter females experience a series of unstable consorts with less adept rams, and hence are mated by a greater number of males during their oestrus. We have thus also identified a novel male–driven mechanism that generates variation in female promiscuity, which suggests that the high levels of female promiscuity in this system are not part of an daptive female tactic to intensify post–copulatory competition between males.
The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing

Summary Polo-like kinase 1 (PLK1) is a widely conserved serine/threonine kinase that regulates progression of multiple stages of mitosis. Although extensive studies about PLK1 functions during cell division have been performed, it is still not known how PLK1 regulates myosin II activation at the equatorial cortex and ingression of the cleavage furrow. In this report, we show that an actin/myosin-II-binding protein, supervillin (SVIL), is a substrate of PLK1. PLK1 phosphorylates Ser238 of SVIL, which can promote the localization of SVIL to the central spindle and association with PRC1. Expression of a PLK1 phosphorylation site mutant, S238A-SVIL, inhibited myosin II activation at the equatorial cortex and induced aberrant furrowing. SVIL has both actin- and myosin-II-binding regions in the N-terminus. Expression of &Dgr;Myo-SVIL (deleted of the myosin-II-binding region), but not of &Dgr;Act-SVIL (deleted of actin-binding region), reduced myosin II activation and caused defects in furrowing. Our study indicates a possible role of phosphorylated SVIL as a molecular link between the central spindle and the contractile ring to coordinate the activation of myosin II for the ingression of the cleavage furrow.
Noradrenergic system of the zebra finch brain: Immunocytochemical study of dopamine‐β‐hydroxylase

Oscine birds are among the few animal groups that have vocal learning, and their brains contain a specialized system for song learning and production. We describe here the immunocytochemical distribution of dopamine‐β‐hydroxylase (DBH), a noradrenergic marker, in the brain of an oscine, the zebra finch (Taeniopygia guttata). DBH‐positive cells were seen in the locus coeruleus, the nucleus subcoeruleus ventralis, the nucleus of the solitary tract, and the caudolateral medulla. Immunoreactive fibers and varicosities had a much wider brain distribution. They were particularly abundant in the hippocampus, septum, hypothalamus, area ventralis of Tsai, and substantia nigra, where they formed dense pericellular arrangements. Significant immunoreactivity was observed in auditory nuclei, including the nucleus mesencephalicus lateralis pars dorsalis, the thalamic nucleus ovoidalis, field L, the shelf of the high vocal center (HVC), and the cup of the nucleus robustus archistriatalis (RA), as well as in song control nuclei, including the HVC, RA, the lateral magnocellular nucleus of the anterior neostriatum, and the dorsomedial nucleus (DM) of the intercollicular complex. Except for the DM, DBH immunoreactivity within song nuclei was comparable to that of surrounding tissues. Conspicuously negative were the lobus paraolfactorius, including song nucleus area X, and the paleostriatum. Our results are in agreement with previous studies of the noradrenergic system performed in nonoscines. More importantly, they provide direct evidence for a noradrenergic innervation of auditory and song control nuclei involved in song perception and production, supporting the notion that noradrenaline is involved in vocal communication and learning in oscines. J. Comp. Neurol. 400:207–228, 1998. © 1998 Wiley‐Liss, Inc.
Do oval posts improve fracture resistance of teeth with oval root canals?

AIM To determine whether the use of oval posts increases fracture resistance of root canal treated teeth with oval-shaped canals. METHODS Extracted mandibular premolars with similar dimensions were decoronated. After root canal treatment, standardized post space preparations were performed to simulate the presence of oval-shaped root canal morphologies. Specimens were randomly assigned to 3 groups (n = 3 × 24). In group SFP (small fiber post), circular posts with a cervical diameter of 1.5 mm were used without additional form-congruent post space preparation. In group LFP (large fiber post), a circular post space preparation was performed to adapt posts with a cervical diameter of 1.9 mm. In group OFP (oval fiber post), oval posts with a long cervical diameter of 1.9 mm and short cervical diameter of 1.3 mm were utilized without additional post space preparation. Posts were cemented with dual-cure resin. All specimens were restored with standardized direct composite crowns. After thermo-mechanical loading in a computer-controlled masticator, all specimens underwent fracture resistance testing. Means and standard deviations were calculated. Data were analyzed using the Kruskal-Wallis test (α = 0.05). RESULTS The highest mean fracture load was observed in group OFP (273N ± 51), the lowest in group LFP (258N ± 72). Kruskal-Wallis indicated no significant differences in fracture resistance among the three experimental groups. CONCLUSIONS Within the limitations of this laboratory study, oval posts did not reveal increased fracture resistance of root canal-treated premolars with oval-shaped root canals compared with circular posts.
The Participation Patterns of Youth with Down Syndrome

Purpose The purpose of this paper was to investigate the participation patterns of children with Down syndrome (DS) using the construct of participation as defined by the International Classification of Functioning Disability and Health (ICF). Methods Sixty-two children with DS were recruited between the ages of 9 and 17 years. All participants were given an interview-administered version of the Children’s Assessment of Participation and Enjoyment (CAPE) to measure participation (1). Results Children with DS participated the most often, based on frequency, in recreational activities (p < 0.001); social activity types represented the greatest extension into the community based on with whom the children participated with (p < 0.05); finally, physical and social activities represented the greatest extension into the community geographically (p < 0.001). In addition, children with DS are significantly more active in activities that are informal in nature. Conclusion Children with DS participate in a number of activities; however, the extent of their participation within these activities differs depending on the participation pattern examined. Implications for educational and community-based programs are discussed.
Wnt signaling mediates regional specification in the vertebrate face

At early stages of development, the faces of vertebrate embryos look remarkably similar, yet within a very short timeframe they adopt species-specific facial characteristics. What are the mechanisms underlying this regional specification of the vertebrate face? Using transgenic Wnt reporter embryos we found a highly conserved pattern of Wnt responsiveness in the developing mouse face that later corresponded to derivatives of the frontonasal and maxillary prominences. We explored the consequences of disrupting Wnt signaling, first using a genetic approach. Mice carrying compound null mutations in the nuclear mediators Lef1 and Tcf4 exhibited radically altered facial features that culminated in a hyperteloric appearance and a foreshortened midface. We also used a biochemical approach to perturb Wnt signaling and found that in utero delivery of a Wnt antagonist, Dkk1, produced similar midfacial malformations. We tested the hypothesis that Wnt signaling is an evolutionarily conserved mechanism controlling facial morphogenesis by determining the pattern of Wnt responsiveness in avian faces, and then by evaluating the consequences of Wnt inhibition in the chick face. Collectively, these data elucidate a new role for Wnt signaling in regional specification of the vertebrate face, and suggest possible mechanisms whereby species-specific facial features are generated.
Exploiting spatial locality in data caches using spatial footprints

Modern cache designs exploit spatial locality by fetching large blocks of data called cache lines on a cache miss. Subsequent references to words within the same cache line result in cache hits. Although this approach benefits from spatial locality, less than half of the data brought into the cache gets used before eviction. The unused portion of the cache line negatively impacts performance by wasting bandwidth and polluting the cache by replacing potentially useful data that would otherwise remain in the cache. This paper describes an alternative approach to exploit spatial locality available in data caches. On a cache miss, our mechanism, called Spatial Footprint Predictor (SFP), predicts which portions of a cache block will get used before getting evicted. The high accuracy of the predictor allows us to exploit spatial locality exhibited in larger blocks of data yielding better miss ratios without significantly impacting the memory access latencies. Our evaluation of this mechanism shows that the miss rate of the cache is improved, on average, by 18% in addition to a significant reduction in the bandwidth requirement.
Minimum-information LQG control part I: Memoryless controllers

With the increased demand for power efficiency in feedback-control systems, communication is becoming a limiting factor, raising the need to trade off the external cost that they incur with the capacity of the controller's communication channels. With a proper design of the channels, this translates into a sequential rate-distortion problem, where we minimize the rate of information required for the controller's operation under a constraint on its external cost. Memoryless controllers are of particular interest both for the simplicity and frugality of their implementation and as a basis for studying more complex controllers. In this paper we present the optimality principle for memoryless linear controllers that utilize minimal information rates to achieve a guaranteed external-cost level. We also study the interesting and useful phenomenology of the optimal controller, such as the principled reduction of its order.
Localizing an automatic inquiry system for public transport information

The paper reports on the development of a spoken dialogue system for providing information about public transport in the Netherlands. It is explained how a German prototype was adapted for Dutch. Emphasis is laid on the specific approach chosen to collect speech material that could be used to gradually improve the system. The pros and cons of this method are discussed.
Effects of facilitated family case conferencing for advanced dementia: A cluster randomised clinical trial

Background Palliative care planning for nursing home residents with advanced dementia is often suboptimal. This study compared effects of facilitated case conferencing (FCC) with usual care (UC) on end-of-life care. Methods A two arm parallel cluster randomised controlled trial was conducted. The sample included people with advanced dementia from 20 Australian nursing homes and their families and professional caregivers. In each intervention nursing home (n = 10), Palliative Care Planning Coordinators (PCPCs) facilitated family case conferences and trained staff in person-centred palliative care for 16 hours per week over 18 months. The primary outcome was family-rated quality of end-of-life care (End-of-Life Dementia [EOLD] Scales). Secondary outcomes included nurse-rated EOLD scales, resident quality of life (Quality of Life in Late-stage Dementia [QUALID]) and quality of care over the last month of life (pharmacological/non-pharmacological palliative strategies, hospitalization or inappropriate interventions). Results Two-hundred-eighty-six people with advanced dementia took part but only 131 died (64 in UC and 67 in FCC which was fewer than anticipated), rendering the primary analysis under-powered with no group effect seen in EOLD scales. Significant differences in pharmacological (P < 0.01) and non-pharmacological (P < 0.05) palliative management in last month of life were seen. Intercurrent illness was associated with lower family-rated EOLD Satisfaction with Care (coefficient 2.97, P < 0.05) and lower staff-rated EOLD Comfort Assessment with Dying (coefficient 4.37, P < 0.01). Per protocol analyses showed positive relationships between EOLD and staff hours to bed ratios, proportion of residents with dementia and staff attitudes. Conclusion FCC facilitates a palliative approach to care. Future trials of case conferencing should consider outcomes and processes regarding decision making and planning for anticipated events and acute illness. Trial registration Australian New Zealand Clinical Trial Registry ACTRN12612001164886
Incremental nature of anterior eye grading scales determined by objective image analysis

Aim: To use previously validated image analysis techniques to determine the incremental nature of printed subjective anterior eye grading scales. Methods: A purpose designed computer program was written to detect edges using a 3×3 kernal and to extract colour planes in the selected area of an image. Annunziato and Efron pictorial, and CCLRU and Vistakon-Synoptik photographic grades of bulbar hyperaemia, palpebral hyperaemia roughness, and corneal staining were analysed. Results: The increments of the grading scales were best described by a quadratic rather than a linear function. Edge detection and colour extraction image analysis for bulbar hyperaemia (r2 = 0.35−0.99), palpebral hyperaemia (r2 = 0.71−0.99), palpebral roughness (r2 = 0.30−0.94), and corneal staining (r2 = 0.57−0.99) correlated well with scale grades, although the increments varied in magnitude and direction between different scales. Repeated image analysis measures had a 95% confidence interval of between 0.02 (colour extraction) and 0.10 (edge detection) scale units (on a 0–4 scale). Conclusion: The printed grading scales were more sensitive for grading features of low severity, but grades were not comparable between grading scales. Palpebral hyperaemia and staining grading is complicated by the variable presentations possible. Image analysis techniques are 6–35 times more repeatable than subjective grading, with a sensitivity of 1.2–2.8% of the scale.
Implementation of an International Information System on Kidney Transplantation

Summary Kidney transplantations are influenced by a number of factors which are as yet partly unknown or correlate, their mutual dependencies being again unknown. Some of these factors are of a regional or organisational nature. One possibility of gaining new knowledge consists in setting up and analysing an extensive database. With the aid of the information system presented, which is part of a worldwide prospective study on kidney transplantations, it has been possible to build up such a database within a period of three years. It contains information on more than 16,000 kidney transplantations including follow-up data. 212 transplantation centers from all over the world participate in this study. First analyses already showed interesting correlations.
Disruption of Visual Awareness during the Attentional Blink Is Reflected by Selective Disruption of Late-stage Neural Processing

Any information represented in the brain holds the potential to influence behavior. It is therefore of broad interest to determine the extent and quality of neural processing of stimulus input that occurs with and without awareness. The attentional blink is a useful tool for dissociating neural and behavioral measures of perceptual visual processing across conditions of awareness. The extent of higher-order visual information beyond basic sensory signaling that is processed during the attentional blink remains controversial. To determine what neural processing at the level of visual-object categorization occurs in the absence of awareness, electrophysiological responses to images of faces and houses were recorded both within and outside the attentional blink period during a rapid serial visual presentation stream. Electrophysiological results were sorted according to behavioral performance (correctly identified targets vs. missed targets) within these blink and nonblink periods. An early index of face-specific processing (the N170, 140- to 220-msec poststimulus) was observed regardless of whether the participant demonstrated awareness of the stimulus, whereas a later face-specific effect with the same topographic distribution (500- to 700-msec poststimulus) was only seen for accurate behavioral discrimination of the stimulus content. The present findings suggest a multistage process of object-category processing, with only the later phase being associated with explicit visual awareness.