Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancing the Performance of Neurofuzzy Predictors by Emotional Learning Algorith

Neural networks and Neurofuzzy models have been successfully used in the prediction of nonlinear time series. Several learning methods have been introduced to train the Neurofuzzy predictors, such as ANFIS, ASMOD and FUREGA. Many of these methods, constructed over Takagi Sugeno fuzzy inference system, are characterized by high generalization. However, they differ in computational complexity. The emotional Learning, which is successfully used in bounded rational decision making, is introduced as an appropriate method to achieve particular goals in the prediction of real world data. For example, predicting the peaks of sunspot numbers (maximum of solar activity) is more important due to its major effects on earth and satellites. The emotional learning based fuzzy inference system (ELFIS) has the advantages of simplicity and low computational complexity in comparison with other multi-objective optimization methods. The efficiency of proposed predictor is shown in two examples of highly nonlinear time series. Appropriate emotional signal is composed for the prediction of solar activity and price of securities. It is observed that ELFIS performs better predictions in the important regions of solar maximum, and is also a fast and efficient algorithm to enhance the performance of ANFIS predictor in both examples.
normoxic recovery signaling in rats exposed to chronic hypoxia and protein and adenylyl cyclase s Altered myocardial G

normoxic recovery signaling in rats exposed to chronic hypoxia and protein and adenylyl cyclase s Altered myocardial G You might find this additional info useful. physiology, especially those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a publishes original papers that deal with diverse area of research in applied
Local and Global Ancestry Inference and Applications to Genetic Association Analysis for Admixed Populations

Genetic association studies in recently admixed populations offer exciting opportunities to identify novel variants underlying phenotypic diversity. At the same time, genetic heterogeneity resulting from population admixture has to be accounted for to ensure validity of association tests. The whole‐genome sequence data and the genome‐wide single‐nucleotide polymorphism chip data for Mexican American individuals provided by Genetic Analysis Workshop 18 (GAW18) presents a unique opportunity to evaluate and compare methods for the statistical analysis of admixed genetic data. We summarize here the five contributions from the GAW18 working group on admixture mapping and adjusting for admixture. Although group members considered a variety of research topics, the general theme was inference and consideration of ancestry admixture in genetic analyses. The topics considered can be grouped into three categories: (1) global and local ancestry inference and estimation, (2) association and admixture mapping, and (3) genotype imputation in admixed samples. We describe the approaches that were used and the most relevant findings from each contribution. We also provide insight into the strengths and limitations of the state‐of‐the‐art methods considered for genetic analyses in admixed populations.
The OECD as Pivot of the Emerging Global Educational Accountability Regime: How Accountable are the Accountants?

Background/Context PISA has catapulted the OECD—an organization whose mission is the global growth of market economies—to a central role in international education policy making, rivaling and sometimes outdoing the various national governments in influence. While claiming scientific evidence as the basis for the accountability regime it promotes, the policy frameworks and principles it has adopted over the past two decades are rooted in ideas about the superiority of market mechanisms that are contested in many member nations. Yet, while exerting strong influence on national educational practices in pursuit of a narrow and contested policy agenda, it is not easily influenced through established democratic processes. Purpose In this paper, I discuss key OECD ideological and policy shifts that form the background for PISA. Secondly, I focus on the OECD's governance mechanisms and the obstacles it presents to public scrutiny. Research Design Drawing on recent scholarship on the power of transnational policy networks to influence national policy through the soft power of epistemic communities, this paper analyzes policy documents and relevant research from OECD and PISA to identify ideological commitments and configurations of power that form the backdrop for PISA. Conclusion I propose that in a world of global policy making, the influence of organizations like the OECD highlights deficits in the constitution of the global democratic public sphere that would foster the accountability of these organizations.
Effects of air temperature and humidity on average daily gain in feedlot cattle of different genotypes

Abstract. The purpose of this study was to observe Holstein, Brown Swiss, Simmental and cross breed Anatolian Black genotypes fattened in feedlot regarding their ability to tolerate temperature and humidity and to compare Temperature Humidity Index types under climatic conditions of Şanliurfa province in Turkey. Data obtained from a commercial farm composed of 70 594 test day records of 11 117 cattle (6 513 Holstein, 3 546 Brown Swiss, 838 Simmental and 220 Anatolian Black Crosses). Meteorological data were provided from nearest weather station located 9.04 km away from feedlot area. THI values were calculated by using daily maximum, minimum and average air temperature and, humidity values according to three different combinations for each animal. Analysis were based on such a model that includes effects of year, sex, age, season, days on feed, beginning stage of fattening and several types of THI. Results showed that, Simmental and Anatolian Black genotypes were slightly more tolerant to heat stress compared to Holstein and Brown Swiss. In addition, Anatolian Black genotype was more sensitive to cold stress when compared to other genotypes. Different breakpoint values for stress and comfort zone intervals were obtained when different combinations of temperature and humidity variable (maximum or minimum) were used in THI formula.
VerbOcean: Mining the Web for Fine-Grained Semantic Verb Relations

Broad-coverage repositories of semantic relations between verbs could benefit many NLP tasks. We present a semi-automatic method for extracting fine-grained semantic relations between verbs. We detect similarity, strength, antonymy, enablement, and temporal happens-before relations between pairs of strongly associated verbs using lexicosyntactic patterns over the Web. On a set of 29,165 strongly associated verb pairs, our extraction algorithm yielded 65.5% accuracy. Analysis of error types shows that on the relation strength we achieved 75% accuracy. We provide the resource, called VERBOCEAN, for download at http://semantics.isi. edu/ocean/.
Treatment of locally advanced breast cancer using primary induction chemotherapy with hormonal synchronization followed by radiation therapy with or without debulking surgery.

Fifty-one patients with stage IIIA or IIIB locally advanced breast cancer received primary induction chemotherapy (hormonal synchronization, 46 patients) to a maximum objective clinical response before proceeding to local therapy. Patients achieving a pathological complete response (CR) received radiation therapy, while patients with residual disease, partial response (PR), or stable disease (NC) received debulking surgery prior to radiation therapy; in all patients, 6 additional months of chemotherapy were administered. Chemotherapy consisted of cyclophosphamide (500 mg/m2 iv) and doxorubicin (30 mg/m2 iv) on day 1; tamoxifen (40 mg/m2 orally) on days 2-6; Premarin (0.625 mg/m2 orally) every 12 hours for three doses, beginning on day 7; and methotrexate (300 mg/m2 iv) followed in 1 hour by 5-fluorouracil (500 mg/m2 iv) on day 8 and leucovorin rescue (10 mg/m2 orally) every 6 hours for six doses, beginning 24 hours after methotrexate. Fifty patients are evaluable with respect to response, time to disease progression, and survival. The rate of objective response to chemotherapy was 90%; 52% of the patients had CR, 38% had PR, and 10% had NC. The median numbers of chemotherapy cycles to achieve CR, PR, and NC were five, four, and four, respectively. Twenty-four patients with CR to chemotherapy were pathologically assessed, 22 by multiple biopsies and 2 by mastectomy. Seventy-one percent of the patients were proven to have pathological CR. All patients completing combined therapy thus far are disease free. Nine of 29 patients with stage IIIB disease have relapsed; 7 of 23 with inflammatory histology have relapsed; and 2 of 20 with stage IIIA disease have relapsed. (ABSTRACT TRUNCATED AT 250 WORDS)
Determining the Volatility of a Price Process in The Presence of Rounding Errors

Let S denote the price process of a security, and suppose that S follow a geometric Brownian motion with volatility ae 2 : We consider the case when the observations at the discrete time points 0; 1=n; 2=n; ¢¢¢ ; 1 are the rounded-o values S (fi n) i=n = finbSi=n=finc (i = 0;¢¢¢ ;n); where fin > 0 is the round-o level corresponding to the sample frequency n. We investigate the asymptotic behavior of the “Realized Volatility” V n = Pn=1 (log(S (fi n) i=n ) i log(S (fin) (ii1)=n )) 2 , which is commonly used as an estimator of the volatility ae 2 . We prove the convergence of V n or scaled V n under dierent conditions on fin. A bias corrected estimator of the volatility is proposed and an associated central limit theorem is shown. Simulation results show that improvement in statistical properties can be substantial.
Patterns of messenger RNA expression for adrenergic receptor subtypes in the rat kidney.

The distribution of mRNA for the rat alpha-1 A/D, alpha-1B, alpha-2A/D (RG20), alpha-2B (RNG), alpha-2C (RG10), beta-1 and beta-2 adrenergic receptors were studied in the rat kidney using in situ hybridization. After hybridized sections were exposed to autoradiography film or dipped in photographic emulsion and counterstained with hematoxylin and eosin, specific and selective labeling patterns characteristic for each probe in the kidney were observed. Labeling with the probe to the alpha-1A/D receptor was only observed in vessels in the renal parenchyma and in the ureter. Alpha-1B receptor mRNA was demonstrated in the outer and inner stripe of the outer medulla, corresponding to segment S3 of proximal tubules and the thick ascending limb of loop of Henle. Alpha-2A/D receptor mRNA was distributed in the inner stripe of the outer medulla and in the inner medulla, corresponding to collecting tubules, and in the ureter. The strongest signal in the kidney was obtained with the alpha-2B receptor probe, showing labelling in the outer stripe of the outer medulla with tubular rays radiating into the cortex, coinciding with segment S3 of proximal tubules. Weak labeling obtained with the alpha-2C receptor probe was present in the renal medulla. Labeling obtained with the probe to the beta-1 receptor was seen in the entire cortex and to a lesser extent also in the outer medulla. In addition, beta-1 receptor mRNA was shown in perirenal adipose tissue and in the ureter. Labeling obtained with the probe to the beta-2 receptor was demonstrated in the outer and inner stripe of the outer medulla. (ABSTRACT TRUNCATED AT 250 WORDS)
Grouping Recorded Music by Structural Similarity

This paper introduces a method for the organization of recorded music according to structural similarity. It uses the Normalized Compression Distance (NCD) to measure the pairwise similarity between songs, represented using beat-synchronous self-similarity matrices. The approach is evaluated on its ability to cluster a collection into groups of performances of the same musical work. Tests are aimed at ﬁnding the combination of system parameters that improve clustering, and at highlighting the beneﬁts and shortcomings of the proposed method. Results show that structural similarities can be well characterized by this approach, given consistency in beat tracking and overall song structure.
The chemotactic activity for granulocytes produced by virally infected fibroblasts is identical to monocyte‐derived interleukin 8

So far, the role of fibroblasts in inflammatory processes has been underestimated. We have previously shown that stimulation of fibroblasts with viruses or bacteria results in a simultaneous production of several cytokines, including interferon‐β, interleukin (IL) 6 and colony‐stimulating factors. We here report that virally infected fibroblasts produce also a chemotactic factor for granulocytes. The activity is inducible not only by measles virus but also by IL 1β and the double‐stranded RNA poly(rI) ˙ poly(rC). This factor, when purified to homogeneity, occurs as a 6–7‐kDa protein doublet upon sodium dodecyl sulfate‐polyacrylamide gel electrophoresis. The pure protein is serologically related to a fully characterized granulocyte chemotactic peptide (GCP) from monocytes, designated IL8. Furthermore, the chemotactic factor from fibroblasts has an NH2‐terminal sequence identical to that of GCP/IL 8, small differences in NH2‐terminal processing being observed. Finally, in addition to diploid fibroblasts, the osteosarcoma MG‐63 cell line is also a producer of GCP/IL 8. It can thus be concluded that GCP/IL8 can be produced by several cell types in response to infection and that fibroblasts can contribute to chemotaxis in inflammation.
Comparison of “Live High-Train Low” in Normobaric versus Hypobaric Hypoxia

We investigated the changes in both performance and selected physiological parameters following a Live High-Train Low (LHTL) altitude camp in either normobaric hypoxia (NH) or hypobaric hypoxia (HH) replicating current “real” practices of endurance athletes. Well-trained triathletes were split into two groups (NH, n = 14 and HH, n = 13) and completed an 18-d LHTL camp during which they trained at 1100–1200 m and resided at an altitude of 2250 m (PiO2 = 121.7±1.2 vs. 121.4±0.9 mmHg) under either NH (hypoxic chamber; FiO2 15.8±0.8%) or HH (real altitude; barometric pressure 580±23 mmHg) conditions. Oxygen saturations (SpO2) were recorded continuously daily overnight. PiO2 and training loads were matched daily. Before (Pre-) and 1 day after (Post-) LHTL, blood samples, VO2max, and total haemoglobin mass (Hbmass) were measured. A 3-km running test was performed near sea level twice before, and 1, 7, and 21 days following LHTL. During LHTL, hypoxic exposure was lower for the NH group than for the HH group (220 vs. 300 h; P<0.001). Night SpO2 was higher (92.1±0.3 vs. 90.9±0.3%, P<0.001), and breathing frequency was lower in the NH group compared with the HH group (13.9±2.1 vs. 15.5±1.5 breath.min−1, P<0.05). Immediately following LHTL, similar increases in VO2max (6.1±6.8 vs. 5.2±4.8%) and Hbmass (2.6±1.9 vs. 3.4±2.1%) were observed in NH and HH groups, respectively, while 3-km performance was not improved. However, 21 days following the LHTL intervention, 3-km run time was significantly faster in the HH (3.3±3.6%; P<0.05) versus the NH (1.2±2.9%; ns) group. In conclusion, the greater degree of race performance enhancement by day 21 after an 18-d LHTL camp in the HH group was likely induced by a larger hypoxic dose. However, one cannot rule out other factors including differences in sleeping desaturations and breathing patterns, thus suggesting higher hypoxic stimuli in the HH group.
Oral Direct Factor Xa Inhibitors

Vitamin K antagonists, such as warfarin, have been the mainstay of oral anticoagulation for many decades. Although effective, warfarin has numerous limitations, including a variable dose requirement from patient to patient because of differences in dietary vitamin K intake, common genetic polymorphisms, and multiple drug interactions that affect its pharmacodynamics and metabolism. Consequently, warfarin requires frequent monitoring to ensure that a therapeutic anticoagulant effect has been achieved because excessive anticoagulation can lead to bleeding, and because insufficient anticoagulation can result in thrombosis. Such monitoring is burdensome for patients and physicians and is costly for the health care system. These limitations have prompted the development of new oral anticoagulants that target either factor Xa or thrombin. Although the path to the development of these drugs has been long, the new drugs are at least as effective and safe as warfarin, but they streamline clinical care because they can be administered in fixed doses without routine coagulation monitoring. This article focuses on rivaroxaban, apixaban, and edoxaban, the oral factor Xa inhibitors in the most advanced stages of development. After 20 years of discovery research, these agents are already licensed for several indications. Thus, the long path to finding replacements for warfarin has finally reached fruition. Therefore, development of the oral factor Xa inhibitors represents a translational science success story.
An NXF1 mRNA with a retained intron is expressed in hippocampal and neocortical neurons and is translated into a protein that functions as an Nxf1 cofactor

A small Nxf1 protein, expressed from an NXF1 mRNA with a retained intron is highly expressed in rodent hippocampal and neocortical neurons, colocalizes with Staufen2 proteins in neuronal RNA granules, is present in polysomes, and replaces Nxt1 as an Nxf1 cofactor in export and expression of mRNA with retained introns.
Engaging and Working in Solidarity With Local Communities in Preparing the Teachers of Their Children

This article analyzes a programmatic effort in teacher education, “The Community Teaching Strand” (CTS), to engage local community members as mentors of teacher candidates (TCs) in two postgraduate teacher preparation programs in a large research university. Three different conceptions of the nature and purpose of teacher–family–community relations frame the analysis: involving families and communities, engaging families and communities, and working in solidarity with families and communities. Three primary research questions are explored in this article: What do TCs learn through their participation in the CTS? To what extent and how do TCs bring community teaching into their classrooms during the program and as first-year teachers? What programmatic features encouraged and/or constrained TC learning from the community mentors? After describing Mountain City’s “Community Teaching Strand,” the article identifies a set of TC learning and practice outcomes as well as a number of tensions that arose in the programs in the attempt to implement engagement and solidarity approaches to working with families and communities. Finally, the implications of this work for teacher education are discussed.
Outcomes of adults hospitalised with severe influenza

Background The aim of this study was to investigate factors affecting clinical outcomes of adults hospitalised with severe seasonal influenza. Methods A prospective, observational cohort study was conducted over 24 months (2007–2008) in two acute, general hospitals. Consecutive, hospitalised adult patients were recruited and followed once their laboratory diagnosis of influenza A/B was established (based on viral antigen detection and virus isolation from nasopharyngeal aspirates collected per protocol). Outcomes studied included in-hospital death, length of stay and duration of oxygen therapy. Factors affecting outcomes were analysed using multivariate Cox proportional hazards models. Sequencing analysis on the neuraminidase gene was performed for available H1N1 isolates. Results 754 patients were studied (influenza A, n=539; >75% H3N2). Their mean age was 70±18 years; co-morbidities and serious complications were common (61–77%). Supplemental oxygen and ventilatory support was required in 401 (53.2%) and 41 (5.4%) patients, respectively. 39 (5.2%) patients died; pneumonia, respiratory failure and sepsis were the causes. 395 (52%) patients received antiviral (oseltamivir) treatment. Omission of antiviral treatment was associated with delayed presentation or negative antigen detection results. The mortality rate was 4.56 and 7.42 per 1000 patient-days in the treated and untreated patients, respectively; among those with co-morbidities, it was 5.62 and 11.64 per 1000 patient-days, respectively. In multivariate analysis, antiviral use was associated with reduced risk of death (adjusted HR (aHR) 0.27 (95% CI 0.13 to 0.55); p<0.001). Improved survival was observed with treatment started within 4 days from onset. Earlier hospital discharge (aHR 1.28 (95% CI 1.04 to 1.57); p=0.019) and faster discontinuation of oxygen therapy (aHR 1.30 (95% CI 1.01 to 1.69); p=0.043) was associated with early treatment within 2 days. Few (n=15) H1N1 isolates in this cohort had the H275Y mutation. Conclusions Antiviral treatment for severe influenza is associated with reduced mortality and improved clinical outcomes.
Species Diversity and Distribution of Ticks (Acari: Ixodidae) in Zabol County, Eastern Iran

Background: Ticks are important vectors of human and animal pathogens. They are considered as main vectors for transmission of many viral, bacterial, rickettsial and parasitical pathogens. The aim of the present study was to find out species diversity of ticks, which infested the domestic ruminants in Zabol County, Eastern Iran in 2012. Methods: Ticks were selected randomly from sheep, goats, cattle and camels. The ticks were collected from the body of infested animals and stored in 70% ethanol, then transported to the laboratory of Zabol University of Medical Sciences. Following examinations under stereomicroscope, ticks were identified using available taxonomic keys. Results: In this study, a total number of 469 adult ticks (381 males and 88 females) were collected. Ticks were classified into 2 genera and 9 species including: Hyalomma dromedarii (17.3%), Hy. schulzei (1.8%), Hy. marginatum (0.5%), Hy. anatolicum excavatum (12.60%), Hy. anatolicum anatolicum (11.2%), Hy. asiaticum asiaticum (11.0%), Rhipicephalus sanguineus (21.2%), Rh. bursa (10.2%) and Rh. turacunis (13.911%). The frequency of genus Hyalomma (54.6%) was higher than Rhipicephalus. Rh. sanguineus was the predominant tick species and accounted for 21.26% of the ticks. The ratio of males was more than the female ticks. Conclusion: Hyalomma and Rhipicephalus species are commonly distributed in the study area. Further investigations are needed to identify the role of above tick species as vectors of pathogenic organisms.