Miracle-dz/UniFAR-FTUs huggingface dataset:
Type of Acidosis and Clinical Outcome in Infantile Gastroenteritis

To explore different types of metabolic acidosis in acute gastroenteritis of infancy, and to correlate it with nutritional status and clinical outcome, we examined prospectively 27 consecutive infants admitted with moderate to severe dehydration and arterial blood pH 7.20. Serum anion gap, creatinine, divalent cations (Ca, Mg), and the anionic contribution of total protein, lactate, and phosphate as well as ketones and urine pH, were determined on admission and compared with age-matched controls. Twenty infants (Group A) presented with normal anion gap (13.1 ± 2.7) associated with hyperchloremia (115.8 ± 4.2 mmol/L, p < 0.01) and diminished bicarbonate (9.7 ± 2.4 mmol/L, p < 0.01), compared with controls. The other seven infants (group B) demonstrated an increased anion gap (26.7 ± 3.2, p < 0.01), associated with significant elevations of lactate (3.4 ± 0.7 mmol/L, p < 0.001), total protein (93.4 ± 12.3 g/L, p < 0.01), as well as phosphate (2.3 ± 0.2 mmol/L, p < 0.01) and creatinine (164.9 ± 45.1 μmol/L, p < 0.001), compared with controls. No significant deviations of blood divalent cations or ketones were noted in both groups. Urine pH was ± 5.5 in all subjects. Analysis of nutritional status and clinical outcome in both groups revealed significant differences. Infants in group B, compared with group A, were significantly more severely malnourished (7 of 7 versus 4 of 20, p < 0.001), were more likely to have prolonged diarrhea ( > 14 days) (5 of 7 versus 3 of 20, p < 0.001), and required longer durations of both intravenous therapy (6.7 ± 2.3 versus 2.2 ± 0.7 days, p < 0.001) and hospitalization (19.4 ± 4.6 versus 5.4 ± 1.6 days, p < 0.001). We conclude that some infants with acute diarrhea may develop severe dehydration and anion-gap acidosis associated with lactic acidemia and renal dysfunction. These high-risk infants more often demonstrate severe malnutrition, persistent course of diarrhea, and prolonged hospital stay. Early identification of such infants, and aggressive therapy, will probably improve outcome.
Two Independent Networks of Interstitial Cells of Cajal Work Cooperatively with the Enteric Nervous System to Create Colonic Motor Patterns

Normal motility of the colon is critical for quality of life and efforts to normalize abnormal colon function have had limited success. A better understanding of control systems of colonic motility is therefore essential. We report here a hypothesis with supporting experimental data to explain the origin of rhythmic propulsive colonic motor activity induced by general distention. The theory holds that both networks of interstitial cells of Cajal (ICC), those associated with the submuscular plexus (ICC–SMP) and those associated with the myenteric plexus (ICC–MP), orchestrate propagating contractions as pacemaker cells in concert with the enteric nervous system (ENS). ICC–SMP generate an omnipresent slow wave activity that causes propagating but non-propulsive contractions (“rhythmic propagating ripples”) enhancing absorption. The ICC–MP generate stimulus-dependent cyclic depolarizations propagating anally and directing propulsive activity (“rhythmic propulsive motor complexes”). The ENS is not essential for both rhythmic motor patterns since distention and pharmacological means can produce the motor patterns after blocking neural activity, but it supplies the primary stimulus in vivo. Supporting data come from studies on segments of the rat colon, simultaneously measuring motility through spatiotemporal mapping of video recordings, intraluminal pressure, and outflow measurements.
Android Malware Detection Based on System Calls

With Android being the most widespread mobile platform, protecting it against malicious applications is essential. Android users typically install applications from large remote repositories, which provides ample opportunities for malicious newcomers. In this paper, we propose a simple, and yet highly effective technique for detecting malicious Android applications on a repository level. Our technique performs automatic classification based on tracking system calls while applications are executed in a sandbox environment. We implemented the technique in a tool called MALINE, and performed extensive empirical evaluation on a suite of around 12,000 applications. The evaluation yields an overall detection accuracy of 93% with a 5% benign application classification error, while results are improved to a 96% detection accuracy with up-sampling. This indicates that our technique is viable to be used in practice. Finally, we show that even simplistic feature choices are highly effective, suggesting that more heavyweight approaches should be thoroughly (re)evaluated. Android Malware Detection Based on System Calls Marko Dimjašević, Simone Atzeni, Zvonimir Rakamarić University of Utah, USA {marko,simone,zvonimir}@cs.utah. edu Ivo Ugrina University of Zagreb, Croatia
Patients with Concordant Triple-Negative Phenotype between Primary Breast Cancers and Corresponding Metastases Have Poor Prognosis

Purpose We investigated the prognostic impact of discordance between the receptor status of primary breast cancers and corresponding metastases. Methods A total 144 patients with breast cancer and distant metastasis were investigated. The estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status of primary tumor and corresponding metastases were assessed. Tumor phenotype according to receptor status was classified as triple-negative phenotype (TNP) or non-TNP. Concordance and discordance was determined by whether there was a change in receptor status or phenotype between primary and metastatic lesions. Results The rates of discordance between primary breast cancer and metastatic lesions were 18.1%, 25.0%, and 10.3% for ER, PR, and HER2, respectively. The rates of concordant non-TNP, concordant TNP and discordant TNP were 65.9%, 20.9%, and 13.2%, respectively. Patients with concordant ER/PR-negative status had worse postrecurrence survival (PRS) than patients with concordant ER/PR-positive and discordant ER/PR status (p=0.001 and p=0.021, respectively). Patients who converted from HER2-positive to negative after distant metastasis had worst PRS (p=0.040). Multivariate analysis showed that concordant TNP was statistically significant factor for worse PRS (p<0.001). Conclusion Discordance in receptor status and tumor phenotype between primary breast cancer and corresponding metastatic lesions was observed. Patients with concordant TNP had worse long-term outcomes than patients with concordant non-TNP and discordant TNP between primary and metastatic breast cancer. Identifying the receptor status of metastatic lesions may lead to improvements in patient management and survival.
High Density Panels Obtained by Welding of Wood Veneers without any Adhesives

High density panels obtained by pressing wood veneers together in plywood or laminated veneer lumber (LVL) assembly configurations, at temperatures of 225°C to 250°C, high pressure and long press times, as long as 60 min or longer, have been shown by tensile tests, X-ray microdensitometry and scanning electron microscopy to present interphases where wood has welded just by application of the press heat alone. Short press times under the same conditions of pressure and temperature yield poor welding, or no welding at all, in the veneers interphases.
‘You can spend your life dying or you can spend your life living’: Identity transition in people who are HIV-positive

This article examines, through the lenses of HIV-positive people, the unique phenomenon of identity transition. This research proposes that life-changing illnesses, such as HIV, are an undesired ‘possession’ that people accept to varying degrees, which we refer to as ‘ownership’. While illnesses, such as HIV compel individuals to undergo a transformation process that usually begins with a deep feeling of detachment, and then proceeds to acceptance of their illness, and to feeling empowered and in control of their HIV status and lives, this process is very complex and non-linear as it involves many iterative progressions in identity transition. These transitions are highly individualistic; however, the underlying theme is that the more positive trajectories were those of people who focus on their new lives, living with HIV (i.e. taking ownership of their illness), rather than focusing on what they have lost when they became HIV-positive. The findings demonstrate that identity transition is a result of the ways that individuals rework, negotiate and transform their roles, actions and behaviours through their active engagement with support mechanisms. This study suggests that it is vital to promote positive interactions with support mechanisms to ensure that those with HIV view themselves positively.
Melatonin Suppression by Static and Extremely Low Frequency Electromagnetic Fields: Relationship to the Reported Increased Incidence of Cancer

An increased cancer incidence has been reported in individuals living and/or working in an environment in which they are exposed to higher than normal artificial electromagnetic fields. One of the most uniform changes associated with the exposure of animals to either pulsed static geomagnetic fields or to sinusoidal extremely low frequency magnetic fields has been a reduction in high night-time levels of melatonin. Melatonin is a hormone produced especially at night in the pineal gland, a pea-sized organ near the center of the human brain. The high nocturnal production of melatonin leads to elevated blood melatonin levels at night as well. The exposure of humans or animals to light (visible electromagnetic radiation) at night rapidly depresses pineal melatonin production and blood melatonin levels. Likewise, the exposure of animals to various pulsed static and extremely low frequency magnetic fields also reduces melatonin levels. Melatonin is a potent oncostatic agent and it prevents both the initiation and promotion of cancer. Reduction of melatonin, at night, by any means, increases cells' vulnerability to alteration by carcinogenic agents. Thus, if in fact artificial electromagnetic field exposure increases the incidence of cancer in humans, a plausible mechanism could involve a reduction in melatonin which is the consequence of such exposures.
Using trust and possibilistic reasoning to deal with untrustworthy communication in VANETs

VANETs allow for unprecedented amounts of information to be sent between participants in traffic. Unfortunately, without countermeasures, they also allow selfish agents to take advantage of communication to improve their own utility. In this paper we present a novel framework for dealing with potentially untrustworthy information. The framework consists primarily of two components: a computational trust model for estimating the amount of uncertainty in received information and a possibilistic beliefs-desires-intentions agent system for reasoning about this uncertain information in order to achieve the driver's goals. We demonstrate the framework's effectiveness in an easy to understand but realistic scenario of a freeway system in which we also show that deceit may have a larger impact on traffic flow than previously thought.
Evaluation of work-related psychosocial factors and regional musculoskeletal pain: results from a EULAR Task Force

Objectives: To establish whether review articles provide consistent conclusions on associations between workplace psychosocial factors and musculoskeletal pain and, if differences exist, to explore whether this is related to the methods used. Methods: Reviews, reported up to February 2007, that included consideration of workplace psychosocial factors and upper limb, back or knee pain were identified through searches of multiple databases. The specific work-related psychosocial factors considered were job demands, support, job autonomy and job satisfaction. The conclusions of each review on one or more of the psychosocial/musculoskeletal pain associations were extracted. Results: 15 review articles were identified that considered one or more of the regional pain syndromes included in the study. For back pain, the most consistent conclusions (four reviews positive out of six) were with high job demands and low job satisfaction. The studies of upper limb pain were exclusively related to shoulder and/or neck pain, and the most consistent positive conclusions were with high and low job demands (four reviews positive out of six and two reviews positive out of three, respectively). For knee pain, only a single review was identified. For individual reviews of back and upper limb pain, there were marked differences in the number of associations concluded to be positive between reviews. Conclusions: The reasons for reviews coming to different conclusions included that they were often evaluating different bodies of evidence (according to their search criteria, the year when the review was conducted, the role that quality assessment played in whether studies contributed to evidence, and the combination of risk factors addressed in individual studies), but more important was whether the review specified explicit criteria for making conclusions on strength of evidence. These conclusions emphasise the importance of developing standardised methods for conducting such evaluations of existing evidence and the importance of new longitudinal studies for clarifying the temporal relationship between psychosocial factors and musculoskeletal pain in the workplace.
Copper oxide as a “self-cleaning” substrate for graphene growth

Commonly used techniques for cleaning copper substrates before graphene growth via chemical vapor deposition (CVD), such as rinsing with acetone, nitric, and acetic acid, and high temperature hydrogen annealing still leave residual adventitious carbon on the copper surface. This residual carbon promotes graphene nucleation and leads to higher nucleation density. We find that copper with an oxidized surface can act as a self-cleaning substrate for graphene growth by CVD. Under vacuum conditions, copper oxide thermally decomposes, releasing oxygen from the substrate surface. The released oxygen reacts with the carbon residues on the copper surface and forms volatile carbon monoxide and carbon dioxide, leaving a clean copper surface free of carbon for large-area graphene growth. Using oxidized electropolished copper foil leads to a reduction in graphene nucleation density by over a factor of 1000 when compared to using chemically cleaned oxygen free copper foil.
Use of low molecular mass heparin (enoxaparin) in newborn infants: a prospective cohort study of 62 patients

Objective: To detail low molecular mass heparin (enoxaparin) use in the first few months of life. Design: Prospective, consecutive cohort of unselected newborn infants. Methods: Newborn infants were divided into groups by gestational age, underlying condition, hepatic and renal function, thrombocytopenia, and prothrombin time (PT/INR). Groups were analysed with respect to many aspects of enoxaparin treatment using multivariate methods. Results: Sixty two newborn infants received enoxaparin representing 5.39 treatment years. Thromboembolic events (TEs) occurred predominantly in the lower and upper venous system in the presence of indwelling catheters (69%). Preterm infants required longer than full term infants to achieve an anti-(factor Xa) level in the target range (six versus two days). Preterm infants required higher doses of enoxaparin than full term infants to maintain anti-(factor Xa) levels in the target range (2.1 v 1.7 mg/kg/12 h). Infants with congenital heart disease (CHD) required less enoxaparin than those without CHD to maintain an anti-(factor Xa) level in the target range (1.7 v 2.1 mg/kg/12 h). Impaired renal and liver function influenced the number of dose changes needed (three versus one a month). Complete or partial resolution of TE was accomplished in 59% of newborn infants. Four infants developed major bleeds (1.2% per patient year). Recurrent TE and clot extension occurred in three infants (0.9% per patient year). Conclusions: Preterm infants are more difficult to treat with enoxaparin than full term infants. Enoxaparin appears to be an alternative to treatment with standard heparin or no treatment.
Magnetic Eddy-Current and Thermal Coupled Models for the Finite-Element Behavior Analysis of Underground Power Cables

We have modeled underground isolated power cables by using magnetic eddy-current (EC) and thermal coupled formulations solved by the finite-element method (FEM). The magnetic field equation expressed in terms of magnetic vector potential (MVP) is strongly coupled with the total current density equation, which includes the source and the EC densities for taking into account skin and proximity effects. The model uses the computed EC density of losses with electric conductivity temperature dependence introduced as a heat source in the free transient thermal equation completed by the convection heat transfer. We studied single and multicircuit three-phase arrangements at various cable spaces in order to analyze the magnetic flux density and the time-space temperature evolution.
Relationship between Histamine2-Receptor Antagonist Medications and Risk of Invasive Breast Cancer

Background: Histamine2-receptor antagonist (H2 blocker) medications are used to treat heartburn, gastroesophageal reflux disease, and ulcers. Some H2 blockers, specifically cimetidine and ranitidine, also increase serum prolactin concentrations. Given the positive relationship between prolactin levels and postmenopausal breast cancer risk, use of H2 blockers is a potential breast cancer risk factor. The few previous studies evaluating this association have been null but have been limited by small sample sizes, and none have evaluated risk by either histologic type or estrogen receptor/progesterone receptor status. Methods: Combining data from two population-based case-control studies conducted in western Washington, we assessed the relationship between use of H2 blockers and risk of different types of breast cancer among 1,941 cases and 1,476 controls 55 to 79 years old. Odds ratios and 95% confidence intervals (95% CI) were calculated using polytomous logistic regression. Results: Current use of H2 blockers overall, cimetidine, and famotidine was not associated with an increased risk of either invasive ductal or invasive lobular breast cancer. Current users of ranitidine had a 2.2-fold (95% CI, 1.1-4.3) increased risk of ductal carcinoma that was confined to a 2.4-fold (95% CI, 1.2-4.9) increased risk of estrogen receptor–positive/progesterone receptor–positive ductal carcinoma. Conclusions: Use of H2 blockers in general is not associated with an increased risk of breast cancer, although current use of ranitidine may increase risk of hormone receptor–positive ductal carcinoma. Further studies to confirm this finding are warranted. (Cancer Epidemiol Biomarkers Prev 2008;17(1):67–72)
Clinical iron deficiency disturbs normal human responses to hypoxia

BACKGROUND. Iron bioavailability has been identified as a factor that influences cellular hypoxia sensing, putatively via an action on the hypoxia-inducible factor (HIF) pathway. We therefore hypothesized that clinical iron deficiency would disturb integrated human responses to hypoxia. METHODS. We performed a prospective, controlled, observational study of the effects of iron status on hypoxic pulmonary hypertension. Individuals with absolute iron deficiency (ID) and an iron-replete (IR) control group were exposed to two 6-hour periods of isocapnic hypoxia. The second hypoxic exposure was preceded by i.v. infusion of iron. Pulmonary artery systolic pressure (PASP) was serially assessed with Doppler echocardiography. RESULTS. Thirteen ID individuals completed the study and were age- and sex-matched with controls. PASP did not differ by group or study day before each hypoxic exposure. During the first 6-hour hypoxic exposure, the rise in PASP was 6.2 mmHg greater in the ID group (absolute rises 16.1 and 10.7 mmHg, respectively; 95% CI for difference, 2.7–9.7 mmHg, P = 0.001). Intravenous iron attenuated the PASP rise in both groups; however, the effect was greater in ID participants than in controls (absolute reductions 11.1 and 6.8 mmHg, respectively; 95% CI for difference in change, –8.3 to –0.3 mmHg, P = 0.035). Serum erythropoietin responses to hypoxia also differed between groups. CONCLUSION. Clinical iron deficiency disturbs normal responses to hypoxia, as evidenced by exaggerated hypoxic pulmonary hypertension that is reversed by subsequent iron administration. Disturbed hypoxia sensing and signaling provides a mechanism through which iron deficiency may be detrimental to human health. TRIAL REGISTRATION. ClinicalTrials.gov (NCT01847352). FUNDING. M.C. Frise is the recipient of a British Heart Foundation Clinical Research Training Fellowship (FS/14/48/30828). K.L. Dorrington is supported by the Dunhill Medical Trust (R178/1110). D.J. Roberts was supported by R&D funding from National Health Service (NHS) Blood and Transplant and a National Institute for Health Research (NIHR) Programme grant (RP-PG-0310-1004). This research was funded by the NIHR Oxford Biomedical Research Centre Programme.
Correlates of intentions to obtain genetic counseling and colorectal cancer gene testing among at-risk relatives from three ethnic groups.

OBJECTIVES An understanding of factors associated with interest in genetic counseling and intentions to obtain colorectal cancer susceptibility testing is an important foundation for developing education, counseling, and genetic services and policies. MATERIALS AND METHODS A survey was mailed to first-degree relatives of patients diagnosed with colorectal cancer. The respondents (n = 426, 77% response rate) are siblings and adult children of Caucasian, Japanese, and Hawaiian ethnicity. Data collection was guided by a conceptual framework and included questions on demographics, family cancer history, predisposing factors (cancer worry, perceived risk, well-being), and enabling factors (decision preferences, social support, and health care factors). Logistic regression analysis on two binary dependent variables (interest in counseling and intentions to get genetic testing) was performed using Generalized Estimating Equations to account for family clusters. RESULTS Forty-five % of respondents were interested in genetic counseling, and 26% "definitely" intended to get genetic testing for colon cancer when available. For counseling interest, the most important predictors were education, Hawaiian ethnicity, cancer worry, and family support. Cancer worry, perceived risk, and age (older) were directly, and Japanese ethnicity was inversely, associated with testing intentions. CONCLUSIONS High rates of interest in cancer genetic testing are similar to those found in other studies. Ethnic differences reveal a paradox between objective population risk (higher for Japanese) and greater concerns (among Hawaiians). The substantial lack of awareness of family history warrants further research. Culturally sensitive education and counseling are needed for managing the likely high demand for personalized information about hereditary cancer risk.