Miracle-dz/UniFAR-FTUs huggingface dataset:
Multisystem dating of modern river detritus from Tajikistan and China: Implications for crustal evolution and exhumation of the Pamir

The Pamir is the western continuation of Tibet and the site of some of the highest mountains on Earth, yet comparatively little is known about its crustal and tectonic evolution and erosional history. Both Tibet and the Pamir are characterized by similar terranes and sutures that can be correlated along strike, although the details of such correlations remain controversial. The erosional history of the Pamir with respect to Tibet is significantly different as well: Most of Tibet has been characterized by internal drainage and low erosion rates since the early Cenozoic; in contrast, the Pamir is externally drained and topographically more rugged, and it has a strongly asymmetric drainage pattern. Here, we report 700 new U-Pb and Lu-Hf isotope determinations and >300 40Ar/39Ar ages from detrital minerals derived from rivers in China draining the northeastern Pamir and >1000 apatite fission-track (AFT) ages from 12 rivers in Tajikistan and China draining the northeastern, central, and southern Pamir. U-Pb ages from rivers draining the northeastern Pamir are Mesozoic to Proterozoic and show affinity with the Songpan-Ganzi terrane of northern Tibet, whereas rivers draining the central and southern Pamir are mainly Mesozoic and show some affinity with the Qiangtang terrane of central Tibet. The eHf values are juvenile, between 15 and −5, for the northeastern Pamir and juvenile to moderately evolved, between 10 and −40, for the central and southern Pamir. Detrital mica 40Ar/39Ar ages for the northeastern Pamir (eastern drainages) are generally older than ages from the central and southern Pamir (western drainages), indicating younger or lower-magnitude exhumation of the northeastern Pamir compared to the central and southern Pamir. AFT data show strong Miocene–Pliocene signals at the orogen scale, indicating rapid erosion at the regional scale. Despite localized exhumation of the Mustagh-Ata and Kongur-Shan domes, average erosion rates for the northeastern Pamir are up to one order of magnitude lower than erosion rates recorded by the central and southern Pamir. Deeper exhumation of the central and southern Pamir is associated with tectonic exhumation of central Pamir domes. Deeper exhumation coincides with western and asymmetric drainages and with higher precipitation today, suggesting an orographic effect on exhumation. A younging-southward trend of cooling ages may reflect tectonic processes. Overall, cooling ages derived from the Pamir are younger than ages recorded in Tibet, indicating younger and higher magnitudes of erosion in the Pamir.
A Simple and Computationally Efficient Approach to Multifactor Dimensionality Reduction Analysis of Gene-Gene Interactions for Quantitative Traits

We present an extension of the two-class multifactor dimensionality reduction (MDR) algorithm that enables detection and characterization of epistatic SNP-SNP interactions in the context of a quantitative trait. The proposed Quantitative MDR (QMDR) method handles continuous data by modifying MDR’s constructive induction algorithm to use a T-test. QMDR replaces the balanced accuracy metric with a T-test statistic as the score to determine the best interaction model. We used a simulation to identify the empirical distribution of QMDR’s testing score. We then applied QMDR to genetic data from the ongoing prospective Prevention of Renal and Vascular End-Stage Disease (PREVEND) study.
Behavioural activation treatment for depression: a review of the literature ; effects of a brief behavioural activation treatment on activity levels and depression

Previous research has shown exercise to be beneficial in the treatment of myositis-affected patients. However, the potential of functional exercises to improve muscle strength and function in the absence of disease progression markers in patient's with Inclusion Body Myositis (IBM) is not well understood. It is believed that the initial exercise dose and patient specificity is of paramount importance in the successful use of this modality in the routine :inanagement and long term treatment of such patients. The objective of this study was to investigate the effects of a homebased, patient-specific functional exercise programme, including aerobic exercise and resistance training, on muscle strength, endurance and function, and the aerobic capacity of the patient. Pre muscle strength and functional assessments, and a maximal aerobic exercise test were conducted on seven IBM patients' prior to a 12-week training period. As part of the patient's routine management, the patients maintained their scheduled visits to the neuromuscular clinic whereby their serum creatine kinase (CK) levels were assessed preand post-training intervention. The patients' were gently and selectively overloaded in the early stages of their 12-week exercise program to encourage compliance and gradual adaptation, and to prevent 'overtraining' early in the program. The exercise program combined upper and lower body resistance training exercises with an aerobic component. It was anticipated that the patients would exercise frequently at low intensities and at volumes that would optimally induce muscular strength and endurance improvements. Integral to the prescription of exercise for this patient group was the patient-specificity of the exercise dose being prescribed and the method of exercise overload. The patient's progress was monitored by fortnightly phone calls; maintenance of the patients scheduled visits to their specialist at the neuromuscular clinic, and a 'training diary' was given to the patient to fill out daily. At the conclusion of the training intervention period, all parameters of muscle strength and function were reassessed, and the patients undertook follow-up testing of their maximal aerobic capacity.
GHK-Cu may Prevent Oxidative Stress in Skin by Regulating Copper and Modifying Expression of Numerous Antioxidant Genes

The copper binding tripeptide GHK (glycyl-l-histidyl-l-lysine) is a naturally occurring plasma peptide that significantly declines during human aging. It has been established that GHK:Copper(2+) improves wound healing and tissue regeneration and stimulates collagen and decorin production. GHK-Cu also supports angiogenesis and nerve outgrowth, improves the condition of aging skin and hair, and possesses antioxidant and anti-inflammatory effects. In addition, it increases cellular stemness and secretion of trophic factors by mesenchymal stem cells. GHK’s antioxidant actions have been demonstrated in vitro and in animal studies. They include blocking the formation of reactive oxygen and carbonyl species, detoxifying toxic products of lipid peroxidation such as acrolein, protecting keratinocytes from lethal Ultraviolet B (UVB) radiation, and blocking hepatic damage by dichloromethane radicals. In recent studies, GHK has been found to switch gene expression from a diseased state to a healthier state for certain cancers and for chronic obstructive pulmonary disease (COPD). The Broad Institute’s Connectivity Map indicated that GHK induces a 50% or greater change of expression in 31.2% of human genes. This paper reviews biological data demonstrating positive effects of GHK in skin and proposes interaction with antioxidant-related genes as a possible explanation of its antioxidant activity.
‘Planning ethics’ 1 and rediscovering the idea of planning 2

This paper is inspired by Sue Hendler’s considerable contributions to the field of ethics and planning. There can be few more insightful vantage points from which to view planning than through exploration of the field’s engagement with ethics. A perspective derived from ethics helps to cut through the analytical noise, to expose often troubling but fundamental issues about the very nature of planning. This paper examines how ethical concerns have been, and are being, understood in planning, and the profound questions which are posed about past, present and future intellectual and professional priorities. It concludes that the planning community needs to rediscover its ethical voice and its confidence in the idea of planning.
Combining Topological and Geometrical Features for Global and Partial 3-D Shape Retrieval

This paper presents a novel framework for 3-D object content-based search and retrieval, appropriate for both partial and global matching applications. The framework is based on a graph representation of a 3-D object which is enhanced by local geometric features. The 3-D object is decomposed into meaningful parts and an attributed graph is constructed based on the connectivity of the parts. Every 3-D part is approximated with a suitable superellipsoid and a novel 3-D shape descriptor, called a 3-D distance field descriptor, is computed and associated to the corresponding graph nodes. The matching process used is based on attributed graph matching algorithm appropriate for this application. The proposed method not only provides successful retrieval results in terms of geometric similarity but also is invariant to rotation, translation and scaling of an object as well as to the different poses of articulated objects. Finally, it can be effectively used for partial and global 3-D object retrieval.
Early Cerebral Constraints on Reading Skills in School‐Age Children: An MRI Study

Reading relies on a left-lateralized network of brain areas that include the pre-lexical processing regions of the ventral stream. Specifically, a region in the left lateral occipitotemporal sulcus (OTS) is consistently more activated for visual presentations of words than for other categories of stimuli. This region undergoes dramatic changes at the functional and structural levels when children learn to read, but little is known about the effects of early cerebral constraints on reading skills. Using anatomical magnetic resonance imaging, we investigated whether the sulcal pattern of the lateral OTS—a stable brain feature—was associated with oral reading skills. The sulcal pattern of the left but not the right lateral OTS was associated with the number of words correctly read in 3 min. This study is the first to evidence that reading is affected by early cerebral constraints, such as the sulcal morphology of the left lateral OTS.
Type 2 Diabetes Screening Test by Means of a Pulse Oximeter

In this paper, we propose a method for screening for the presence of type 2 diabetes by means of the signal obtained from a pulse oximeter. The screening system consists of two parts: the first analyzes the signal obtained from the pulse oximeter, and the second consists of a machine-learning module. The system consists of a front end that extracts a set of features form the pulse oximeter signal. These features are based on physiological considerations. The set of features were the input of a machine-learning algorithm that determined the class of the input sample, i.e., whether the subject had diabetes or not. The machine-learning algorithms were random forests, gradient boosting, and linear discriminant analysis as benchmark. The system was tested on a database of <inline-formula><tex-math notation="LaTeX"> $\text{1157}$</tex-math></inline-formula> subjects (two samples per subject) collected from five community health centers. The mean receiver operating characteristic area found was <inline-formula><tex-math notation="LaTeX"> $\text{69.4}$</tex-math></inline-formula>% (median value <inline-formula><tex-math notation="LaTeX"> $\text{71.9}$</tex-math></inline-formula>% and range <inline-formula><tex-math notation="LaTeX"> $[\text{75.4}-\text{61.1}]$</tex-math></inline-formula>%), with a specificity = <inline-formula> <tex-math notation="LaTeX">$\text{64}$</tex-math></inline-formula>% for a threshold that gave a sensitivity = <inline-formula><tex-math notation="LaTeX">$\text{65}$</tex-math></inline-formula>%. We present a screening method for detecting diabetes that has a performance comparable to the glycated haemoglobin (haemoglobin A1c HbA1c) test, does not require blood extraction, and yields results in less than 5 min.
Marine stratocumulus aerosol-cloud relationships in the MASE-II experiment: Precipitation susceptibility in eastern Pacific marine stratocumulus

Observational data on aerosol-cloud-drizzle relationships in marine stratocumulus are presented from the second Marine Stratus/Stratocumulus Experiment (MASE-II) carried out in July 2007 over the eastern Pacific near Monterey, California. Observations, carried out in regions of essentially uniform meteorology with localized aerosol enhancements due to ship exhaust (“ship tracks”), demonstrate, in accord with those from numerous other field campaigns, that increased cloud drop number concentration Nc and decreased cloud top effective radius r_e are associated with increased subcloud aerosol concentration. Modulation of drizzle by variations in aerosol levels is levels is clearly evident. Variations of cloud base drizzle rate R_(cb) are found to be consistent with the proportionality, R_(cb) / H^3/N_c, where H is cloud depth. Simultaneous aircraft and A-Train satellite observations are used to quantify the precipitation susceptibility of clouds to aerosol perturbations in the eastern Pacific region.
Using a Naturalistic Sport Context to Train Social Skills in Children

ABSTRACT Researchers have utilized sports activities to deliver social skills training (SST) programs to children. Using a multiple-baseline across behaviors design, we examined whether a brief SST program delivered during a soccer camp would increase social skills and athletic competencies. Each participant’s self-concept, and his interest in soccer were evaluated. Results suggest that the SST procedure effectively increased targeted social skills. Further, participants reported increased interest in soccer and higher overall self-concept. Our results suggest that similar effects can be achieved in a relatively short, but intense, camp that utilizes SST and sports-skill training components. Limitations and implications are discussed.
Integrating Neurobiology and Psychopathology into Evidence-Based Treatment of Social Anxiety Disorder

Abstract Social anxiety disorder (SAD) is a common, chronic psychiatric disorder characterized by a persistent fear of social or performance situations in which embarrassment can occur. This disorder typically appears during the mid-adolescent years and is unremitting throughout life if not properly treated. SAD presents as two subtypes: the more common and debilitating generalized form, and the nongeneralized form, which consists predominantly of performance anxiety. The majority of patients with SAD have comorbid mental disorders, including mood, anxiety, and substance abuse. No single development theory has been proposed to account for the origins of SAD, although current understanding of the etiology of SAD posits an interaction between psychological and biological factors. Risk factors include environmental and parenting influences and dysfunctional cognitive and conditioning events in early childhood. The neurobiology of SAD appears to involve neurochemical dysfunction, as evidenced by studies of neuroreceptor imaging, neuroendocrine function, and profiles of response to specific medications. Clinical trials have demonstrated that benzodiazepines and antidepressants are effective in the treatment of SAD. The selective serotonin reuptake inhibitors are emerging as the first-line treatment for SAD, based on their proven safety, tolerability, and efficacy. Goals for ongoing future research include development of approaches to achieve remission, to convert nonresponders and partial responders to full responders, and to prevent relapse and maintain long-term efficacy. This monograph explores the epidemiology, clinical presentation, and differential diagnosis of SAD, with a focus on neural circuitry of social relationships and neurochemical dysfunction. The prevalence, rates of recognition and treatment, patterns of comorbidity, quality-of-life issues, and natural history of SAD are discussed as well as pharmacologic and psychosocial treatment strategies for SAD.
Everyday consumption norms as discourses of the good life in pre-socialist and socialist Hungary

Everyday consumption norms are abundantly evident in empirical studies, yet focussed theoretical discussion is lacking. This article fills this gap by proposing three theoretical points, developed through the case study of changing personal consumption norms and public moralizing in pre-war and socialist Hungary. It suggests first that consumption norms draw on cosmologies that involve pragmatic beliefs alongside strong evaluations which refer to ethical visions of how to live and who to be. Second, it shows that many of these ethical visions are embedded in practices as practical ethics rather than being articulated in abstract terms. Finally, it argues that personal consumption norms are simultaneously subject to individual appropriation and constrained by collective discursive and practical conventions. Thus, norms serve as a terrain through which shared ethical visions and pragmatic beliefs are negotiated and modified.
Compliance with supportive periodontal therapy.

All new patients commencing supportive periodontal therapy (periodontal maintenance) after treatment in a specialist periodontal practice from 1983 to 1986 were identified from practice records. Based on their compliance with the recommended schedule of visits, the patients were classified as either compliant or non-compliant. The results indicated that there were no significant differences between compliant and non-compliant patients with regards to age, sex, number of missing teeth, plaque score, or periodontal disease severity. More non-compliant patients than compliant patients were smokers (P less than 0.05). By contrast, more compliant patients were covered by private dental insurance (P less than 0.01) and more had periodontal surgery during treatment (P less than 0.001). Only 36% of the initial patient sample was found to be compliant at the end of 1989, with the greatest patient loss in the first year of supportive periodontal therapy of about 42%. The annual attrition rate decreased in subsequent years to average about 10% of those remaining in each year, indicating that a patient is more likely to remain compliant if he or she attends for at least 1 year of supportive periodontal treatment. Non-compliant patients were sent a questionnaire seeking reasons for their non-compliance. Forty percent of the questionnaires were returned. The most common reason given for non-compliance was that a general dental practitioner was attending to the patient's periodontal treatment needs. Many considered supportive periodontal therapy to be too expensive, while a significant proportion considered that they no longer required treatment. (ABSTRACT TRUNCATED AT 250 WORDS)
Tonal Expectations Influence Early Pitch Processing

The present study investigated the ERP correlates of the influence of tonal expectations on pitch processing. Participants performed a pitch discrimination task between penultimate and final tones of melodies. These last two tones were a repetition of the same musical note, but penultimate tones were always in tune whereas final tones were slightly out of tune in half of the trials. The pitch discrimination task allowed us to investigate the influence of tonal expectations in attentive listening and, for penultimate tones, without being confounded by decisional processes (occurring on final tones). Tonal expectations were manipulated by a tone change in the first half of the melodies that changed their tonality, hence changing the tonal expectedness of penultimate and final tones without modifying them acoustically. Manipulating tonal expectations with minimal acoustic changes allowed us to focus on the cognitive expectations based on listeners' knowledge of tonal structures. For penultimate tones, tonal expectations modulated processing within the first 100 msec after onset resulting in an Nb/P1 complex that differed in amplitude between tonally related and less related conditions. For final tones, out-of-tune tones elicited an N2/P3 complex and, on in-tune tones only, tonal manipulation elicited an ERAN/RATN-like negativity overlapping with the N2. Our results suggest that cognitive tonal expectations can influence pitch perception at several steps of processing, starting with early attentional selection of pitch.
HUBUNGAN LOCUS OF CONTROL DENGAN KOMITMEN ORGANISASI PADA KARYAWATI YANG BERUMAH TANGGA DI PT.X TANGERANG

Sebagai karyawati yang berumah tangga dituntut untuk tetap komitmen pada perusahaannya begitu pula di dalam rumah tangganya. Komitmen terhadap organisasi bukan sekedar loyalitas terhadap perusahaan, melainkan sebuah proses yang terus berlangsung untuk menunjukkan perhatian mereka terhadap perusahaan. Karyawati dengan peran gandanya sering mengalami konflik antara keharusan untuk berkomitmen terhadap pekerjaan dan rumah tangganya. Salah satu faktor kepribadian yang menentukan keberhasilan dalam menjalani peran sebagai ibu rumah tangga dan sebagai karyawati adalah locus of control. Locus of control adalah suatu konsep yang menunjukkan derajat seberapa jauh seseorang mempersepsikan adanya hubungan kedekatan antara tindakan-tindakan yang dilakukannya dengan hasil yang ia terima, yaitu apakah peristiwa-peristiwa yang dialaminya merupakan akibat dari tindakan-tindakannya ataukah lebih disebabkan oleh kekuatan-kekuatan diluar kontrol dirinya. Kata Kunci : Locus Of Control, Komitmen Organisasi
In vivo hippocampal glucose metabolism in mesial temporal lobe epilepsy

Background: The appearance of decreased 2-[18F]fluoro-2-deoxy-d-glucose (FDG) uptake in the mesial temporal region in temporal lobe epilepsy may simply reflect loss of gray matter due to hippocampal atrophy. Increased partial volume effects due to atrophic hippocampi may further increase appearance of hypometabolism. Methods: The authors used a combination of MRI-PET coregistration, with MRI-based gray matter segmentation, and partial volume correction to improve the examination of hippocampal specific glucose uptake in FDG PET. The goal was to determine 1) if relative mesial temporal hypometabolism is an artifact of gray matter (hippocampal) atrophy, 2) whether hippocampal metabolism correlates with atrophy evaluated on MRI, and 3) if MRI-based partial volume correction influences measurement of hippocampal metabolic-volume relationships, including epilepsy lateralization. Results: Findings showed that ipsilateral hippocampi of mesial temporal lobe epilepsy (MTLE) are relatively hypometabolic per unit of gray matter volume, and that hippocampal metabolism directly correlates with hippocampal volume. Specifically, partial volume corrected hippocampal metabolism correlated strongly (r = 0.613, p < 0.001) with hippocampal volume. Without partial volume correction, a weaker, but still significant, correlation was present (r = 0.482, p < 0.001). Degree of asymmetry was consistently greater and provided higher sensitivity of lateralization with partial volume vs non–partial volume corrected metabolic measurements. Conclusions: Although, decreased metabolism may occur in the absence of neuronal cell loss, hippocampal atrophy and presumed degree of neuronal cell loss appears to be a primary factor involved in the cause of decreased metabolism in epileptogenic hippocampi. Partial volume correction is recommended for optimal interpretation of hippocampal structure and function relationships.