Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychometric Properties of The Greek Version of the Test of Performance Strategies-Competition Scale (TOPS-CS)

Psychometric Properties of The Greek Version of the Test of Performance Strategies-Competition Scale (TOPS-CS) The aim of the present study was to examine the psychometric properties of the Test of Performance Strategies-Competition scale (TOPS-CS; Thomas et al., 1999) in Greek athletic population. The TOPS-CS was designed to assess eight psychological strategies used by athletes in competition (activation, automaticity, emotional control, goal-setting, imagery, negative thinking, relaxation and self-talk). In order to evaluate the psychometric properties of the inventory, two different research studies were conducted in two different age groups (n1=382 athletes, aged 16 to 20 years and n2=343 athletes, aged 12 to 15 years). Furthermore, 263 athletes, (aged 16 to 20 years) completed the TOPS-CS, purposing to perform confirmatory factor analysis. The results of the first study supported the initial factorial structure of the TOPS-CS for athletes aged 16-20 years. Reliability analysis also provided adequate evidence for the internal consistency and stability of the scale for Greek athletes of this age. However, for athletes aged 12 to 15 years, the validity and reliability of the inventory were questionable and further research is required.
On the Average Complexity of Sphere Decoding in Lattice Space-Time Coded MIMO Channel

The exact average complexity analysis of the basic sphere decoder for general space-time codes applied to multiple-input multiple-output (MIMO) wireless channel is known to be difficult. In this work, we shed the light on the computational complexity of sphere decoding for the quasi-static, LAttice Space-Time (LAST) coded MIMO channel. Specifically, we drive an upper bound of the tail distribution of the decoder's computational complexity. We show that, when the computational complexity exceeds a certain limit, this upper bound becomes dominated by the outage probability achieved by LAST coding and sphere decoding schemes. We then calculate the minimum average computational complexity that is required by the decoder to achieve near optimal performance in terms of the system parameters. Our results indicate that there exists a cut-off rate (multiplexing gain) for which the average complexity remains bounded.
Margin Requirements , Demand Pressure , and Equity Option Returns

Margin requirements are an important factor in asset and derivatives markets. In option markets, traders face margin requirements both for the options themselves and for hedging-related positions in the underlying stock market. We show that these requirements are compensated by a significant margin premium in the cross-section of equity option returns. The direction of this effect depends on demand pressure: If end-users are on the long side of the market, option returns fall with margins, while they increase otherwise. Our results are statistically and economically significant and robust to different margin specifications and various control variables. We explain our findings by a model in which derivatives dealers are funding-constrained and require a premium for satisfying the end-users’ option demand.
To fill or not to fill: The gas station problem

In this article we study several routing problems that generalize shortest paths and the traveling salesman problem. We consider a more general model that incorporates the actual cost in terms of gas prices. We have a vehicle with a given tank capacity. We assume that at each vertex gas may be purchased at a certain price. The objective is to find the cheapest route to go from s to t, or the cheapest tour visiting a given set of locations. We show that the problem of finding a cheapest plan to go from s to t can be solved in polynomial time. For most other versions, however, the problem is NP-complete and we develop polynomial-time approximation algorithms for these versions.
Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy

Significance Cardiac failure is a leading cause of mortality worldwide and a major financial burden for healthcare systems. New tools for understanding cardiovascular disease and developing better therapeutic approaches are therefore needed. To this end, transcriptional regulation has been extensively studied in cardiac hypertrophy and failure, but there is still a lack of understanding of the epigenetic framework in which transcription factors act. Our report adds significant knowledge to the field because we demonstrate, in vivo, that a complex and specific epigenetic signature regulates gene expression by modulating promoters and enhancers, a large number of which have been described here. These findings advance our understanding of the mechanisms underlying this pathology. Cardiac hypertrophy, initially an adaptive response of the myocardium to stress, can progress to heart failure. The epigenetic signature underlying this phenomenon is poorly understood. Here, we report on the genome-wide distribution of seven histone modifications in adult mouse cardiomyocytes subjected to a prohypertrophy stimulus in vivo. We found a set of promoters with an epigenetic pattern that distinguishes specific functional classes of genes regulated in hypertrophy and identified 9,207 candidate active enhancers whose activity was modulated. We also analyzed the transcriptional network within which these genetic elements act to orchestrate hypertrophy gene expression, finding a role for myocyte enhancer factor (MEF)2C and MEF2A in regulating enhancers. We propose that the epigenetic landscape is a key determinant of gene expression reprogramming in cardiac hypertrophy and provide a basis for understanding the role of chromatin in regulating this phenomenon.
A Bi-Level Energy-Saving Dispatch in Smart Grid Considering Interaction Between Generation and Load

The energy-saving dispatch could significantly enhance the energy consumption and carbon dioxide emission reduction, as well as the sustainable development of the socio economy in China. With the rapid growth of smart grid, the use of demand response to dispatch loads with flexible consumption time and/or quantity has been a new trend in power industry. This paper proposes a new energy-saving dispatch problem while considering energy-saving and emission-reduction potentials of generation and demand sides, as well as the interaction between the two. A bi-level optimization model is established to address the interaction between the energy-saving dispatch of thermal units and that of users. The objective function of the upper level considers both the electric power generation cost and the carbon emission cost of thermal units, while the lower level integrates both compensation and incentive costs of electricity consumers into its objective function according to the influences of their regulation-based demand response to the power grid. Moreover, user benefits of reducing downtime and avoiding frequent load restarting are also considered in the lower layer model. An iterative algorithm is proposed and the improved nondominated sorting genetic algorithm II (NSGA-II) method is used to solve the lower-layer model for seeking the optimal compromise solution on the Pareto frontier, which is derived by maximum deviations and entropy-based multiple attributes decision making method. Comparing with general NSGA-II and multiobjective genetic algorithms, the improved NSGA-II method can improve the spatial distribution of Pareto solution set and reduce the number of iterations, thus having stronger consistency among multiple objective functions and better performance.
The mother-child relationship and child behaviour : a comparison of Turkish and English families

The overarching goal of this thesis was to compare the mother-child relationship and child behaviour across cultures. The three articles in this thesis were part of a multi-method investigation comparing England (an individualistic culture) and Turkey (a collectivistic culture). Accounts from two children and their mothers were obtained from 218 two-parent families in total. Mothers completed questionnaires, children were interviewed using the Berkeley Puppet Interview, and observations recorded during various play tasks. The study was unique as it recorded the perspectives of mothers and young children aged from 4 to 8 in each family across cultures. Results showed that English mothers used more positive methods of discipline with their older children, and reported less conflict with both of their children compared to Turkish mothers. In contrast, English children reported more anger and hostility from their mothers than did their Turkish peers (Paper 1). Cultural differences in maternal values partially explained these differences in positive discipline and anger and hostility (Paper 1). Using structural equation modelling, partial cross-cultural measurement invariance for parenting and child adjustment was revealed (Paper 2), and a stronger association between parenting and child adjustment was found for the English versus Turkish families (Paper 2). Finally, multi-level modelling yielded significant prediction of children’s adjustment from both family-wide and child-specific aspects of parenting (Paper 3). The implications of the findings include appreciating different perspectives of parenting when conducting cross-cultural research (Paper 1); the culturally distinct meanings of both parent and child adjustment should be considered when interpreting their association (Paper 2); and that differential parenting within families can also have distinct cultural meaning (Paper 3). Future research would benefit from exploring within-and between-cultural differences in parent-child relationships further, across multiple countries, over time and in larger samples.
Reactive Agents and Perceptual Ambiguity

Reactive agents are generally believed to be incapable of coping with perceptual ambiguity (i.e., identical sensory states that require different responses). However, a recent finding suggests that reactive agents can cope with perceptual ambiguity in a simple model (Nolfi, 2002). This paper investigates to what extent reactive and nonreactive agents can cope with perceptual ambiguity, and which strategies are employed when doing so. A model of active categorical perception (called Acp) is introduced. In Acp, situated agents with different types of neurocontrollers are optimized to categorize objects by adaptively coordinating action and perception. Our experiments show that both nonreactive and reactive agents can cope with perceptual ambiguity. An analysis of the behavior reveals that nonreactive agents use their internal memory to cope with perceptual ambiguity, while reactive agents use the environment as an external memory to compensate for their lack of an internal memory. We conclude that reactive agents can cope with perceptual ambiguity in the context of active categorical perception, and that they can organize their behavior according to stimuli that are no longer present, especially when they incorporate a nonlinear sensorimotor mapping. Moreover, we may conclude that sensory state-transition diagrams provide insight into the strategies employed by reactive agents to deal with perceptual ambiguity, and their use of the environment as an external memory.
Delving Deep into Personal Photo and Video Search

The ubiquity of mobile devices and cloud services has led to an unprecedented growth of online personal photo and video collections. Due to the scarcity of personal media search log data, research to date has mainly focused on searching images and videos on the web. However, in order to manage the exploding amount of personal photos and videos, we raise a fundamental question: what are the differences and similarities when users search their own photos versus the photos on the web? To the best of our knowledge, this paper is the first to study personal media search using large-scale real-world search logs. We analyze different types of search sessions mined from Flickr search logs and discover a number of interesting characteristics of personal media search in terms of information needs and click behaviors. The insightful observations will not only be instrumental in guiding future personal media search methods, but also benefit related tasks such as personal photo browsing and recommendation. Our findings suggest there is a significant gap between personal queries and automatically detected concepts, which is responsible for the low accuracy of many personal media search queries. To bridge the gap, we propose the deep query understanding model to learn a mapping from the personal queries to the concepts in the clicked photos. Experimental results verify the efficacy of the proposed method in improving personal media search, where the proposed method consistently outperforms baseline methods.
Who’s the Boss? Explaining Gender Inequality in Entrepreneurial Teams

Sociologists have examined gender inequalities across a wide array of social contexts. Yet, questions remain regarding how inequalities arise among autonomous groups pursuing economic goals. In this article, we investigate mixed-sex entrepreneurial teams to unpack the mechanisms by which gender inequality in leadership emerges, despite strong pressures toward merit-based organizing principles. We theorize the potentially competing relationships between merit and gender and explore the contingencies moderating their effects. Drawing on a unique, nationally representative dataset of entrepreneurial teams sampled from the U.S. population in 2005, we use conditional logistic regression to test our hypotheses. We demonstrate that merit’s effect becomes much larger when multiple merit-based criteria provide consistent predictions for which team member is superior to others, and when entrepreneurial founders adopt bureaucratic templates to construct new ventures. However, gender stereotypes of leaders pervasively constrain women’s access to power positions, and gender’s effect intensifies when spousal relationships are involved. Women have reduced chances to be in charge if they co-found new businesses with their husbands, and some family conditions further modify women’s chances, such as husbands’ employment and the presence of children.
Self-decontaminating photocatalytic zinc oxide nanorod coatings for prevention of marine microfouling: a mesocosm study

Abstract The antifouling (AF) properties of zinc oxide (ZnO) nanorod coated glass substrata were investigated in an out-door mesocosm experiment under natural sunlight (14:10 light: dark photoperiod) over a period of five days. The total bacterial density (a six-fold reduction) and viability (a three-fold reduction) was significantly reduced by nanocoatings in the presence of sunlight. In the absence of sunlight, coated and control substrata were colonized equally by bacteria. MiSeq Illumina sequencing of 16S rRNA genes revealed distinct bacterial communities on the nanocoated and control substrata in the presence and absence of light. Diatom communities also varied on nanocoated substrata in the presence and the absence of light. The observed AF activity of the ZnO nanocoatings is attributed to the formation of reactive oxygen species (ROS) through photocatalysis in the presence of sunlight. These nanocoatings are a significant step towards the production of an environmentally friendly AF coating that utilizes a sustainable supply of sunlight.
Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes

Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells and they retain intact antigen for prolonged periods. We found that human FDC isolated from patients on ART retain infectious HIV within a non-degradative cycling compartment and transmit infectious virus to uninfected CD4 T cells in vitro. Importantly, treatment of the HIV+ FDC with a soluble complement receptor 2 purges the FDC of HIV virions and prevents viral transmission in vitro. Our results provide an explanation for how FDC can retain infectious HIV for extended periods and suggest a therapeutic strategy to achieve cure in HIV-infected humans.
Subfertility in bulls carrying a nonsense mutation in transmembrane protein 95 is due to failure to interact with the oocyte vestments†

Abstract In a recent genome-wide association study, 40 Fleckvieh bulls with exceptionally poor fertility were found to be homozygous for a nonsense mutation in the transmembrane protein 95 (TMEM95) encoding gene. Ejaculates from these individuals exhibited normal sperm concentration, morphology, viability, and motility. However, only 1.7% of inseminations resulted in pregnancies. The aim of this study was to examine the effect of this mutation in TMEM95 on bovine sperm function in vitro. Sperm from homozygous (mt/mt) males had lower in vitro fertility than sperm from wild-type (wt/wt) or heterozygous (wt/mt) bulls (P < 0.01). In addition, early embryo division was affected in the mt/mt group (P < 0.01). This translated into a lower (P < 0.01) blastocyst rate at day 8. Fluorescent staining revealed that TMEM95 is lost after the acrosome reaction. This led us to hypothesize that TMEM95 might be involved in events that lead to sperm-oocyte interaction. After fertilization, a lower number (P < 0.01) of sperm from mt/mt bulls bound to the zona pellucida (ZP). Sperm from mt/mt bulls were also less able to penetrate oocytes with no ZP (P< 0.01). However, when sperm from these animals were injected into mouse oocytes, they could decondense as successfully as sperm from wt/wt bulls. No differences between genotypes were observed in the ability of sperm to retain motility in an ex vivo oviduct, or in the percentage of sperm exhibiting markers for capacitation and acrosomal reaction. These results suggest that fertilization failure in mt/mt bulls is due to the inability of their sperm to interact with the oocyte vestments. Summary Sentence Bulls homozygous for a nonsense mutation in TMEM95 exhibit extremely poor fertility in vivo and in vitro. This is due to the inability of sperm from these animals to interact with the vestments of the oocyte.
Metformin in the treatment of non-alcoholic fatty liver disease: safety, efficacy and mechanism

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease etiology worldwide. It encompasses a spectrum ranging from simple steatosis to non-alcoholic steatohepatitis. Although the physiopathology of NAFLD is partly known. Insulin-resistance plays a central role in the development and progression of NAFLD. Several studies have indicated that metformin, as an insulin sensitizer, effectively improves NAFLD and its related metabolic status. Metformin was effective in reducing enzyme levels in the short period, but very limited and controversial information are available on liver histology. Larger randomized controlled trials of sufficient duration using clearly defined histological endpoints are needed to fully assess the efficacy of this drug in modifying the natural history of NAFLD.
Poorly differentiated (anaplastic) seminoma of the testis

Anaplastic seminoma constitutes approximately 17% of total experience with seminoma at Memorial Sloan‐Kettering Cancer Center. Among 25 previosly untreated patients, 11 (44%) were clinical Stage I, and 14 (56%) were clinical Stage II or III. Treatment of these 25 patients with the same regimens employed for classical seminoma yielded an overall 80% 5‐year apparent cure rate. Survival rates were poor in eight previously treated patients referred with recurrence.
SAR Image Stacking for the Exploitation of Long-Term Coherent Targets

This letter shows that in a repeat-pass data set of synthetic aperture radar (SAR) images, a long-term coherent component, when present, can be recovered by coherent temporal filtering of the SAR images and can successively form interferograms with higher signal-to-noise ratio. The validity of the idea is confirmed through simulations and one example with real TerraSAR-X data. The theoretical necessity of using long-term interferograms is also discussed and linked to autoregressive processes, starting from the observation that the optimal weighting is given by the inverse of the covariance matrix.
Human Missense Mutations in Regulator of G Protein Signaling 2 Affect the Protein Function Through Multiple Mechanisms

Regulator of G protein signaling 2 (RGS2) plays a significant role in alleviating vascular contraction and promoting vascular relaxation due to its GTPase accelerating protein activity toward Gαq. Mice lacking RGS2 display a hypertensive phenotype, and several RGS2 missense mutations have been found predominantly in hypertensive human subjects. However, the mechanisms whereby these mutations could impact blood pressure is unknown. Here, we selected 16 rare, missense mutations in RGS2 identified in various human exome sequencing projects and evaluated their ability to inhibit intracellular calcium release mediated by angiotensin II receptor type 1 (AT1R). Four of them had reduced function and were further investigated to elucidate underlying mechanisms. Low protein expression, protein mislocalization, and reduced G protein binding were identified as likely mechanisms of the malfunctioning mutants. The Q2L mutant had 50% lower RGS2 than wild-type (WT) protein detected by Western blot. Confocal microscopy demonstrated that R44H and D40Y had impaired plasma membrane targeting; only 46% and 35% of those proteins translocated to the plasma membrane when coexpressed with Gαq Q209L compared with 67% for WT RGS2. The R188H mutant had a significant reduction in Gαq binding affinity (10-fold increase in Ki compared with WT RGS2 in a flow cytometry competition binding assay). This study provides functional data for 16 human RGS2 missense variants on their effects on AT1R-mediated calcium mobilization and provides molecular understanding of those variants with functional loss in vitro. These molecular behaviors can provide insight to inform antihypertensive therapeutics in individuals with variants having reduced function.
Isoflurane does not depress the hypoxic response of rabbit carotid body chemoreceptors.

UNLABELLED Whether volatile anesthetics have an effect on the peripheral chemoreceptors is controversial, possibly because of differences in end-tidal CO(2) concentrations. We studied the effect of isoflurane on the hypoxic chemosensitivity of carotid body chemoreceptors at three different PaCO(2) levels before and during the administration of 1.0% isoflurane (0.5 minimum alveolar anesthetic concentration) in six normothermic New Zealand white rabbits anesthetized with thiopental. The response of the chemoreceptors was fitted to the equation: Frequency (Hz) = a + b x PaCO(2) + c x (1/PaO(2)) + Dx (1/PaO(2))(2). Mean values for the coefficients a, b, c and d for the control state were -4.5, 0.13, 771, and 6332, respectively. This relationship was not changed by addition of isoflurane at 1.0% end-tidal concentration (P = 0.40, analysis of variance). We conclude that isoflurane at 1.0% end-tidal concentration does not depress the hypoxic response of rabbit carotid body chemoreceptors during either hypo-, normo-, or hypercapnia. IMPLICATIONS By measuring single-fiber chemoreceptor activity in anesthetized rabbits, we showed that isoflurane at 1.0% end-tidal concentration does not depress the hypoxic chemosensitivity of peripheral chemoreceptors during either hypo-, normo-, or hypercapnia in this species.