Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating prostate tumor cells detected by reverse transcription-PCR in men with localized or castration-refractory prostate cancer: concordance with CellSearch assay and association with bone metastases and with survival.

BACKGROUND Reverse transcription-PCR (RT-PCR) assays have been used for analysis of circulating tumor cells (CTCs), but their clinical value has yet to be established. We assessed men with localized prostate cancer or castration-refractory prostate cancer (CRPC) for CTCs via real-time RT-PCR assays for KLK3 [kallikrein-related peptidase 3; i.e., prostate-specific antigen (PSA)] and KLK2 mRNAs. We also assessed the association of CTCs with disease characteristics and survival. METHODS KLK3, KLK2, and PSCA (prostate stem cell antigen) mRNAs were measured by standardized, quantitative real-time RT-PCR assays in blood samples from 180 localized-disease patients, 76 metastatic CRPC patients, and 19 healthy volunteers. CRPC samples were also tested for CTCs by an immunomagnetic separation system (CellSearch; Veridex) approved for clinical use. RESULTS All healthy volunteers were negative for KLK mRNAs. Results of tests for KLK3 or KLK2 mRNAs were positive (> or =80 mRNAs/mL blood) in 37 patients (49%) with CRPC but in only 15 patients (8%) with localized cancer. RT-PCR and CellSearch CTC results were strongly concordant (80%-85%) and correlated (Kendall tau, 0.60-0.68). Among CRPC patients, KLK mRNAs and CellSearch CTCs were closely associated with clinical evidence of bone metastases and with survival but were only modestly correlated with serum PSA concentrations. PSCA mRNA was detected in only 7 CRPC patients (10%) and was associated with a positive KLK mRNA status. CONCLUSIONS Real-time RT-PCR assays of KLK mRNAs are highly concordant with CellSearch CTC results in patients with CRPC. KLK2/3-expressing CTCs are common in men with CRPC and bone metastases but are rare in patients with metastases diagnosed only in soft tissues and patients with localized cancer.
Cost‐effectiveness evaluation of clobetasol propionate shampoo (CPS) maintenance in patients with moderate scalp psoriasis: a Pan‐European analysis

Background Scalp psoriasis is a difficult to treat and usually chronic manifestation of psoriasis. The CalePso study showed that CPS (Clobex® Shampoo) in maintenance therapy of scalp psoriasis (twice weekly) significantly increases the probability of keeping patient under remission during 6 months, compared with vehicle (40.3% relapses vs. 11.6% relapses, ITT).
Violence in Lesbian Relationships

Despite the increase in research on domestic violence during the last two decades, little attention has been given to the problem of partner abuse among homosexual couples. The present research takes a step toward developing an understanding of homosexual partner abuse by examining the incidence, forms, and correlates of violence in lesbian relationships. Based on questionnaire data from 100 lesbian victims, the study addresses, in particular, the relationships between lesbian battering and (1) abusers' dependence on their partners, and (2) perceived power imbalances between partners in abusive lesbian relationships. In addition, the study explores the extent to which responses from the lesbian community and others to victims of abuse may serve to prevent or exacerbate lesbian battering. The article concludes by raising questions to guide future research.
Adsorption Characteristics of As(III) and As(V) with Titanium Dioxide Loaded Amberlite XAD-7 Resin

The adsorption characteristics of As(V) and As(III) on titanium dioxide loaded Amberlite XAD-7 resin have been studied. The resin was prepared by impregnation of Ti(OC_2H_5)_4 followed by hydrolysis with ammonium hydroxide. Batch adsorption experiments were carried out as a function of the pH, shaking time and the concentration of As(V) and As(III) ions. The resin showed a strong adsorption for As(V) from pH 1 to 5 and for As(III) from pH 5 to 10. The adsorption isotherm data for As(V) at pH 4 fitted well to a Langmuir equation with a binding constant of 59 dm^3 mol^−1 and a capacity constant of 0.063 mmol g^−1. The data for As(III) at pH 7 also fitted well to a Langmuir equation with a binding constant of 5.4 dm^3 mol^−1 and a capacity constant of 0.13 mmol g^−1. The effect of diverse ions on the adsorption of arsenic was also studied. Column adsorption experiments showed that the adsorption of As(III) is more favorable compared to As(V), due to both the faster adsorption and larger capacity for As(III) than As(V).
Kinematics and workspace analysis of a three-axis parallel manipulator: the Orthoglide

The paper addresses kinematic and geometrical aspects of the Orthoglide, a three-DOF parallel mechanism. This machine consists of three fixed linear joints, which are mounted orthogonally, three identical legs and a mobile platform, which moves in the Cartesian x-y-z space with fixed orientation. New solutions to solve inverse/direct kinematics are proposed, and we perform a detailed workspace and singularity analysis, taking into account specific joint limit constraints.
Improving Learning through Interventions of Student-Generated Questions and Concept Maps

Using the principles of the scholarship of teaching and learning, we evaluated 2 learning strategies to determine if they could improve student exam performance in general psychology. After the second of 3 exams, we gave students the option of participating in a specific learning activity and assessed its impact using the third exam. In Study 1, participating students generated a minimum of 3 questions per week over course material. Lower performing students who participated improved their exam performance such that they were indistinguishable from stronger students who did not participate. In Study 2, students had the option of generating concept maps over course material. Generating concept maps significantly improved performance.
The relationship between attitudes toward science and science achievement

This study investigated the relationship between elementary pupils' attitudes toward science and their science achievement. Residualized gain scores were used to analyze the data. By using residualized gain scores, the effects of individual differences can be minimized. In addition to controlling for these differences, residualized gain scores do not possess the measurement errors that are normally associated with simple change scores. The subjects of this study were 583 intermediate elementary pupils. The average class size was 21. A pretest-posttest design was used. To insure consistency in the teaching of the lesson, each teacher was given an identical detailed science lesson that included all the instructions and materials needed for the activity. The pupils were pre- and posttested. The pupils' science achievement was assessed by a test, the “Hough Pupil Process Test. ” It consisted of multiple choice and fill-in questions. The attitude instrument, the “Hough Attitude Inventory,” was given to the elementary pupils involved in this study. It was field tested and found to discern attitudes. The instrument consisted of six statements to which the subjects responded by circling either yes, I don't know, or no. The analysis revealed that there was a significant relationship between the pupils' residualized gain scores on the “Hough Pupil Process Test” and their residualized gain scores on the “Hough Attitude Inventory” (r = 0.45).
A population-based cohort of adults with asthma: mortality and participation in a long-term follow-up

ABSTRACT Background and objective: Asthma is a major public health concern. The aim of this study was to characterize a large population-based cohort of adults with asthma, and to study factors associated with all-cause mortality and non-participation in a long-term follow-up. Design: Random and stratified samples from five population-based cohorts were clinically examined during 1986–2001, and all subjects with asthma were included in the study (n = 2055, age 19–72 years, 55% women). Independent associations between different risk factors and (i) mortality and (ii) non-participation in a clinical follow-up in 2012–2014 were estimated. Results: In 1986–2001, 95% reported any wheeze and/or attacks of shortness of breath in the past 12 months, and/or asthma medication use. Over the up to 28 years of follow-up time, the cumulative mortality was 22.7%. Male gender, current smoking, and lower forced expiratory volume in 1 sec of predicted (FEV1% of predicted) were independent risk factors for mortality, while obesity was associated with non-participation in the follow-up. Older ages, ischemic heart disease, and low socioeconomic status were associated with both mortality and non-participation. Conclusions: The risk factors associated with mortality in this adult population-based asthma cohort were similar to those commonly identified in general population samples, i.e. male gender, current smoking, and lower FEV1% of predicted, while obesity was associated with non-participation in a long-term follow-up. Ischemic heart disease, low socioeconomic status, and older ages were associated with both mortality and non-participation.
Effect of inoculant strain and organic matter content on kinetics of 2,4-dichlorophenoxyacetic acid degradation in soil

We monitored rates of degradation of soluble and sorbed 2,4-dichlorophenoxyacetic acid (2,4-D) in low-organic-matter soil at field capacity amended with 1, 10, or 100 micrograms of 2,4-D per g of wet soil and inoculated with one of two bacterial strains (MI and 155) with similar maximum growth rates (mu max) but significantly different half-saturation growth constants (Ks). Concentrations of soluble 2,4-D were determined by analyzing samples of pore water pressed from soil, and concentrations of sorbed 2,4-D were determined by solvent extraction. Between 65 and 75% of the total 2,4-D was present in the soluble phase at equilibrium, resulting in soil solution concentrations of ca. 8, 60, and 600 micrograms of 2,4-D per ml, respectively. Soluble 2,4-D was metabolized preferentially; this was followed by degradation of both sorbed (after desorption) and soluble 2,4-D. Rates of degradation were comparable for the two strains at soil concentrations of 10 and 100 micrograms of 2,4-D per g; however, at 1 microgram/g of soil, 2,4-D was metabolized more rapidly by the strain with the lower Ks value (strain MI). We also monitored rates of biodegradation of soluble and sorbed 2,4-D in high-organic-matter soil at field capacity amended with 100 micrograms of 2,4-D per g of wet soil and inoculated with the low-Ks strain (strain MI). Ten percent of total 2,4-D was present in the soluble phase, resulting in a soil solution concentration of ca. 30 micrograms of 2,4-D per ml. (ABSTRACT TRUNCATED AT 250 WORDS)
On Using References as Evidence

Summary Background: One has to start to consider references as a kind of evidence similar to measured data and observations. Moreover, proper referencing adds to the credibility of a paper and gives appropriate credits to work of others. Experience of reviewers and editors indicate that there is room for improvement in the way that our scientific evidence base is referred to. Objective: To provide guidelines for referencing in medical informatics publications. Method: The authors have collected examples of poor as well as good referencing as encountered in manuscripts submitted for review as well as in published literature. Results and Conclusion: A set of 12 rules for proper referencing was derived. The rationale for each rule is provided and examples of rule violations and proper use of the rule are pre sented.
Measuring participation in childhood disability: how does the capability approach improve our understanding?

implicit assumption. The ICF definition of pertinent personal factors describes traits that affect decision-making, but ‘choice’ is not stated explicitly. The capability approach considers the range of experiences and life situations as ‘possible functionings’, described by Sen as ‘beings’ and ‘doings’. 3 Participation, as defined in the ICF, is consistent with the ‘doings’, whilst ‘beings’, such as being happy, are more consistent with subjective ‘quality of life’. In the capability approach, ‘achieved functioning’ (which is analogous to performance in the ICF) is moderated by a person’s capacity, opportunity, and choice. Capability in this context describes a person’s capacity and the opportunities typically afforded them by environmental factors; Sen describes ‘conversion factors’ for available resources as personal factors, and social and physical environmental factors. The range of ‘possible functionings’ for disabled children, their ‘capability set’, may be restricted due to their capacity (by virtue of impairments), or be limited by their social and physical environment. According to Sen’s paradigm, what is important is that children ‘have the capability to participate, or the real, effective opportunities and freedom to participate’. 8 Then, whether functioning is achieved is a matter of personal choice to participate in specific life situations. Lists of key ‘capabilities’ have been proposed; however, the need for a definitive list is debated. Sen proposes that a democratic process should determine which capabilities should be included in specific circumstances. 9
TGF-β1 promotes cerebral cortex radial glia-astrocyte differentiation in vivo

The major neural stem cell population in the developing cerebral cortex is composed of the radial glial cells, which generate glial cells and neurons. The mechanisms that modulate the maintenance of the radial glia (RG) stem cell phenotype, or its differentiation, are not yet completely understood. We previously demonstrated that the transforming growth factor-β1 (TGF-β1) promotes RG differentiation into astrocytes in vitro (Glia 2007; 55:1023-33) through activation of multiple canonical and non-canonical signaling pathways (Dev Neurosci 2012; 34:68-81). However, it remains unknown if TGF-β1 acts in RG-astrocyte differentiation in vivo. Here, we addressed the astrogliogenesis induced by TGF-β1 by using the intraventricular in utero injection in vivo approach. We show that injection of TGF-β1 in the lateral ventricles of E14,5 mice embryos resulted in RG fibers disorganization and premature gliogenesis, evidenced by appearance of GFAP positive cells in the cortical wall. These events were followed by decreased numbers of neurons in the cortical plate (CP). Together, we also described that TGF-β1 actions are region-dependent, once RG cells from dorsal region of the cerebral cortex demonstrated to be more responsive to this cytokine compared with RG from lateral cortex either in vitro as well as in vivo. Our work demonstrated that TGF-β1 is a critical cytokine that regulates RG fate decision and differentiation into astrocytes in vitro and in vivo. We also suggest that RG cells are heterogeneous population that acts as distinct targets of TGF-β1 during cerebral cortex development.
Accelerated failure time model for case‐cohort design with longitudinal covariates subject to measurement error and detection limits

Biomarkers are often measured over time in epidemiological studies and clinical trials for better understanding of the mechanism of diseases. In large cohort studies, case‐cohort sampling provides a cost effective method to collect expensive biomarker data for revealing the relationship between biomarker trajectories and time to event. However, biomarker measurements are often limited by the sensitivity and precision of a given assay, resulting in data that are censored at detection limits and prone to measurement errors. Additionally, the occurrence of an event of interest may preclude biomarkers from being further evaluated. Inappropriate handling of these types of data can lead to biased conclusions. Under a classical case cohort design, we propose a modified likelihood‐based approach to accommodate these special features of longitudinal biomarker measurements in the accelerated failure time models. The maximum likelihood estimators based on the full likelihood function are obtained by Gaussian quadrature method. We evaluate the performance of our case‐cohort estimator and compare its relative efficiency to the full cohort estimator through simulation studies. The proposed method is further illustrated using the data from a biomarker study of sepsis among patients with community acquired pneumonia. Copyright © 2015 John Wiley & Sons, Ltd.
The Information Processing of Pictures in Print Advertisements

This study postulates that the presence of a dominant picture in a print ad can alter a consumer's cognitive activity while viewing the ad. Using the findings of previous research, we develop a model of the process by which a viewer evaluates, encodes, and stores information found in the ad. This model is tested in a laboratory setting. The results clearly indicate that the way a message is conveyed (pictorially or verbally), whether the viewer is given some reference point for encoding the picture (framed or not framed), and the type of claim made (objective, subjective, or characterization) have a significant effect on the processing of the information presented in the advertisements. These differences in processing are also shown to affect the viewer's brand attitudes and purchase intentions.
A multilingual approach to conceptual development in technical contexts

Abstract The focus of this paper is a multilingual intervention in Mechanics I, a core subject in the Mechanical Engineering curriculum. The multilingual intervention, which involved the subject and communication lecturer in a co-teaching process, encouraged students to use their first language (L1) for purposes of conceptual development. The findings indicate that when students learned concepts in their L1, their general understanding was enhanced. The findings also show that students’ acquisition of academic and technical English (an additional language for most students in the study) was improved when they were able to use the L1 to think through calculations, problems, diagrams and the other mathematical applications which form the basis of Mechanics I. The study highlights the relationship between the students’ conceptual development and their access to an appropriate language for conceptualisation. It shows that students were unable to respond to required tasks at an adequate level when they had limited linguistic resources for the processes demanded in advanced learning. When students were able to draw on the resources of a familiar language they were better able to develop higher order concepts.
China's recruitment of African university students: policy efficacy and unintended outcomes

This article explores how Sino-African relations are affected by the growing number of Africans who pursue higher education in China. China actively recruits African university students in order to increase soft power and generate income from the export of education services. Semi-structured interviews with African university students suggest that China fails to reach these policy objectives because the students are disappointed with the quality of the education they receive. However, the students engage in trade and contribute to the fast-growing export of Chinese products to African markets, thereby reinforcing the ties between China and Africa in unintended ways.
An X-Ray Study of Magnetic Field Strengths and Particle Content in the Lobes of FR II Radio Sources

We present a Chandra and XMM-Newton study of X-ray emission from the lobes of 33 classical double radio galaxies and quasars. We report new detections of lobe-related X-ray emission in 11 sources. Together with previous detections, we find that X-ray emission is detected from at least one radio lobe in ∼ 75% of the sample. For all of the lobe detections, we find that the measured X-ray flux can be attributed to inverse Compton scattering of the cosmic microwave background radiation, with magnetic field strengths in the lobes between 0.3Beq and 1.3Beq, where the value Beq corresponds to equipartition between the electrons and magnetic field, assuming a filling factor of unity. There is a strong peak in the magnetic field strength distribution at B ∼ 0.7Beq. We find that more than 70% of the radio lobes are either at equipartition or electron dominated by a small factor. The distribution of measured magnetic field strengths differs for narrow- and broad-line objects, in the sense that broad-line radio galaxies and quasars appear to be further from equipartition; however, this is likely to be due to a combination of projection effects and worse systematic uncertainty in the X-ray analysis for those objects. Our results suggest that the lobes of classical double radio sources do not contain an energetically dominant proton population, because this would require the magnetic field energy density to be similar to the electron energy density rather than the overall energy density in relativistic particles.
Secure and constant cost public cloud storage auditing with deduplication

Data integrity and storage efficiency are two important requirements for cloud storage. Proof of Retrievability (POR) and Proof of Data Possession (PDP) techniques assure data integrity for cloud storage. Proof of Ownership (POW) improves storage efficiency by securely removing unnecessarily duplicated data on the storage server. However, trivial combination of the two techniques, in order to achieve both data integrity and storage efficiency, results in non-trivial duplication of metadata (i.e., authentication tags), which contradicts the objectives of POW. Recent attempts to this problem introduce tremendous computational and communication costs and have also been proven not secure. It calls for a new solution to support efficient and secure data integrity auditing with storage deduplication for cloud storage. In this paper we solve this open problem with a novel scheme based on techniques including polynomial-based authentication tags and homomorphic linear authenticators. Our design allows deduplication of both files and their corresponding authentication tags. Data integrity auditing and storage deduplication are achieved simultaneously. Our proposed scheme is also characterized by constant realtime communication and computational cost on the user side. Public auditing and batch auditing are both supported. Hence, our proposed scheme outperforms existing POR and PDP schemes while providing the additional functionality of deduplication. We prove the security of our proposed scheme based on the Computational Diffie-Hellman problem, the Static Diffie-Hellman problem and the t-Strong Diffie-Hellman problem. Numerical analysis and experimental results on Amazon AWS show that our scheme is efficient and scalable.
Older adults catch up to younger adults on a learning and memory task that involves collaborative social interaction

Learning and memory abilities tend to decline as people age. The current study examines the question of whether a learning situation that emphasises collaborative social interaction might help older persons overcome age-related learning and memory changes and thus perform similarly to younger persons. Younger and Older participants (n = 34 in each group) completed the Barrier Task (BT), a game-like social interaction where partners work together to develop labels for a set of abstract tangrams. Participants were also administered standard clinical neuropsychological measures of memory, on which the Older group showed expected inferiority to the Younger group. On the BT, the Older group performed less well than the Younger group early on, but as the task progressed, the performance of the Older group caught up and became statistically indistinguishable from that of the Younger group. These results can be taken to suggest that a learning milieu characterised by collaborative social interaction can attenuate some of the typical memory disadvantages associated with being older.