Miracle-dz/UniFAR-FTUs huggingface dataset:
Tbx1 Regulates Proliferation and Differentiation of Multipotent Heart Progenitors

Rationale: TBX1 encodes a T-box transcription factor implicated in DiGeorge syndrome, which affects the development of many organs, including the heart. Loss of Tbx1 results into hypoplasia of heart regions derived from the second heart field, a population of cardiac progenitors cells (CPCs). Thus, we hypothesized that Tbx1 is an important player in the biology of CPCs. Objective: We asked whether Tbx1 is expressed in multipotent CPCs and, if so, what role it may play in them. Methods and Results: We used clonal analysis of Tbx1-expressing cells and loss and gain of function models, in vivo and in vitro, to define the role of Tbx1 in CPCs. We found that Tbx1 is expressed in multipotent heart progenitors that, in clonal assays, can give rise to 3 heart lineages expressing endothelial, smooth muscle and cardiomyocyte markers. In multipotent cells, Tbx1 stimulates proliferation, explaining why Tbx1−/− embryos have reduced proliferation in the second heart field. In this population, Tbx1 is expressed while cells are undifferentiated and it disappears with the onset of muscle markers. Loss of Tbx1 results in premature differentiation, whereas gain results in reduced differentiation in vivo. We found that Tbx1 binds serum response factor, a master regulator of muscle differentiation, and negatively regulates its level. Conclusions: The Tbx1 protein marks CPCs, supports their proliferation, and inhibits their differentiation. We propose that Tbx1 is a key regulator of CPC homeostasis as it modulates positively their proliferation and negatively their differentiation.
The effect of a career choice guidance on self-reported psychological problems

Late adolescents with career choice problems often have psychological problems as well. The starting point of this study was the question of career choice counselors whether potential clients with career choice problems and psychological problems could be accepted in career choice intervention, or whether it was better to advise them to seek help for their psychological problems. We investigated whether a successful career choice intervention reduced psychological problems, and whether this program was equally effective in participants with low and with high levels of psychological problems. Participants were 45 Dutch students (age 17–24) with career choice problems. They had above average levels of self-reported psychological problems before the start of the intervention. These problems decreased significantly following the intervention. With regard to vocational commitment development, the intervention was equally effective for participants with low or average and with (very) high levels of psychological problems before the start of the intervention.
Spiritual Capital: Wealth We Can Live By

1. The Monster That Consumes Itself 2. Spiritual Capital 3. The Motivations That Drive Us 4. The Individual Motivations 5. SQ: Spiritual Intelligence 6. The Twelve Principles of Transformation 7. Individual SQ processes 8. How Shift Happens 9. Shifting Corporate Culture 10. A New Knights Templar? 11. Is It Still Capitalism?
Delay Analysis for Wireless Networks With Single Hop Traffic and General Interference Constraints

We consider a class of wireless networks with general interference constraints on the set of links that can be served simultaneously at any given time. We restrict the traffic to be single-hop, but allow for simultaneous transmissions as long as they satisfy the underlying interference constraints. We begin by proving a lower bound on the delay performance of any scheduling scheme for this system. We then analyze a large class of throughput optimal policies which have been studied extensively in the literature. The delay analysis of these systems has been limited to asymptotic behavior in the heavy traffic regime and order results. We obtain a tighter upper bound on the delay performance for these systems. We use the insights gained by the upper and lower bound analysis to develop an estimate for the expected delay of wireless networks with mutually independent arrival streams operating under the well-known maximum weighted matching (MWM) scheduling policy. We show via simulations that the delay performance of the MWM policy is often close to the lower bound, which means that it is not only throughput optimal, but also provides excellent delay performance.
Evolution of the Hubble sequence in hierarchical models for galaxy formation

ABSTRACT We present a model for the broad morphological distinction between the disk andspheroidal components of galaxies. Elaborating on the hierarchical clustering scheme ofgalaxy formation proposed by Cole et al, we assume that galaxies form stars quiescentlyin a disk until they are disrupted into a spheroidal conﬁguration by mergers. Bulges andspheroids may continue to accrete gas from their hot coronae, and so they may growdisks again. Thus, an individual galaxy may pass through various phases of disk orspheroid dominance during its lifetime. To distinguish between disks and spheroids weadd one additional free parameter to the semianalytic model of Cole et al. which we ﬁxby requiring that the predicted morphological mix should match that observed locally.Assuming an Ω = 1, standard cold dark matter cosmology, we calculate formation andmerging histories, and the evolution in colour, luminosity and morphology of the galaxypopulations in diﬀerent environments.Our model predicts that the bulges of spiralswereassembled before the spheroids of ellipticals and the spheroids of cluster ellipticals wereassembled before those of ﬁeld ellipticals. About 50% of ellipticals, but only about 15%of spirals, have undergone a major merger during the redshift interval 0.0 ≤ z ≤ 0.5. In spite of their violent formation history, elliptical galaxies turn out to have colour-magnitude diagrams with remarkably small scatter. Apart from a general blueing ofthe galaxy population with redshift, the colour-magnitude diagrams are remarkablysimilar at redshift z = 0.5 and at the present day. The morphological mix of galaxiesthat become rich cluster members at high redshift is dominated by spiral galaxies,due to the long timescale for galaxy mergers compared with the timescale for clusterassembly at high redshift. The assembly of low redshift clusters is slower, allowingmore galaxy mergers to occur in the progenitor halos. As a result z = 0 rich clustersbecome E/S0 dominated and we ﬁnd a “Butcher-Oemler” eﬀect that becomes weakerfor poorer groups at high redshift. The ﬁeld luminosity function of red galaxies showslittle evolution out to z ≃ 1 and the reddest galaxies at these redshifts are as brightas their local counterparts. The blue luminosity function, on the other hand, evolvesrapidly with redshift, increasing its characteristic luminosity and becoming steeper atthe faint end. These trends are similar to those recently observed in the Canada-FranceRedshift Survey.Our calculationsserveto demonstratethat a simple prescriptionfor thedistinction between disks and spheroids that is compatible with hierarchical clusteringgoes a long way towards explaining many of the systematic trends observed in thegalaxy population.Key words: Galaxies:evolution-galaxies: formation-galaxies.
Device mobility management in content-centric networking

Due to rapid developments in mobile technologies as well as various embedded multimedia features, user created mobile contents are on the increase, in terms of both quality and quantity, and at the same time are shared in real time. To keep pace with such trends, a new networking technology called content-centric networking has appeared. However, it does not consider the extra requirements to support device movements. Thus, this article proposes a mobility management scheme for CCN to provide faster service access latency and lower routing overhead.
Human migration, railways and the geographic distribution of leprosy in Rio Grande do Norte State--Brazil.

INTRODUCTION Leprosy is a public health problem in Brazil where 31,044 new cases were detected in 2013. Rio Grande do Norte is a small Brazilian state with a rate of leprosy lower than other areas in the same region, for unknown reasons. OBJECTIVES We present here a review based on the analysis of a database of registered leprosy cases in Rio Grande do Norte state, comparing leprosy's geographic distribution among municipalities with local socio-economic and public health indicators and with historical documents about human migration in this Brazilian region. RESULTS The current distribution of leprosy in Rio Grande do Norte did not show correlation with socio-economic or public health indicators at the municipal level, but it appears related to economically emerging municipalities 100 years ago, with spread facilitated by railroads and train stations. Drought-related migratory movements which occurred from this state to leprosy endemic areas within the same period may be involved in the introduction of leprosy and with its present distribution within Rio Grande do Norte. CONCLUSIONS Leprosy may disseminate slowly, over many decades in certain circumstances, such as in small cities with few cases. This is a very unusual situation currently and a unique opportunity for epidemiologic studies of leprosy as an emerging disease.
Influence of NK cell count on the survival of patients with diffuse large B-cell lymphoma treated with R-CHOP

Background Although adding rituximab to the chemotherapy regimen of cyclophosphamide, vincristine, doxorubicin, and prednisone (R-CHOP) has improved clinical outcomes of patients with diffuse large B-cell lymphoma (DLBCL), several recent studies have shown that the effect of rituximab is dominantly in the non-germinal center (non-GC) subtype compared to the germinal center (GC) subtype. Natural killer (NK) cell count, a surrogate marker of immune status, is associated with clinical outcomes in DLBCL patients in the rituximab era. We investigated whether the impact of NK cells on clinical outcomes differed according to the immunophenotype of DLBCL. Methods This study analyzed 72 DLBCL patients treated with R-CHOP between January 2010 and January 2014. Results Low NK cell counts (<100/µL) were associated with poor progression-free survival (PFS) and overall survival (OS) compared to high NK cell counts. In multivariate analysis, low NK cell count was an independent prognostic factor for PFS and OS. However, survival did not significantly differ between the GC and non-GC subtypes. We examined the clinical influence of NK cells according to the immunophenotype and found that low NK cell counts were significantly associated with poor PFS and OS in non-GC cases, but not in GC cases. Conclusion Low NK cell counts at diagnosis are associated with poor clinical outcomes in DLBCL patients treated with R-CHOP therapy. However, the impact is significant only in non-GC subtype DLBCL, not in the GC subtype.
Bridging the Gap between Intrinsic and Perceived Relevance in Snippet Generation

Snippet generation plays an important role in a search engine. Good snippets provide users a good indication on the main content of a search result related to the query and on whether one can find relevant information in it. Previous studies on snippet generation focused on selecting sentences that are related to the query and to the document. However, resulting snippet may look highly relevant while the document itself is not. A missing factor that has not been considered is the consistency between the perceived relevance by the user in reading the snippet and the intrinsic relevance of the document. This factor is important to avoid generating a seemingly relevant snippet for an irrelevant document and vice versa. In this paper, we incorporate this factor in a snippet generation method that imposes the constraint that the snippet of a more relevant document should also be more relevant to the query. We derive a set of pairwise preferences between sentences from relevance judgments. We then use this set to train a gradient boosting decision tree to model a sentence scoring function used in snippet generation. Compared to the existing snippet generation methods and to the snippets generated by a commercial search engine, our snippets are more consistent with the true relevance of the documents. When the snippets are incorporated into a document ranking function, we also observe a significant improvement in retrieval effectiveness. This study shows the importance to generate snippets indicating the right level of relevance to the search results.
Treatment of patients with multiple myeloma over 65 yr: more tolerability or better response?

Two‐thirds of newly diagnosed patients with multiple myeloma (MM) are over 65 yr and/or physically unfit. Such patients are not eligible for high‐dose chemotherapy or stem cell transplantation. The treatment aims in these patients should be to prolong survival by obtaining the best possible response, while maintaining good tolerability. The aim of our study was to evaluate the response to treatment and treatment‐related toxicities in patients treated with conventional and novel protocols.
An extension of the Cobham-Semënov Theorem

Abstract Let θ, θ′ be two multiplicatively independent Pisot numbers, and let U, U′ be two linear numeration systems whose characteristic polynomial is the minimal polynomial of θ and θ′, respectively. For every n ≥ 1, if A ⊆ ℕn is U-and U′ -recognizable then A is definable in 〈ℕ: + 〉.
Disability and Youth Sport

1. Bringing disability into youth sport Hayley Fitzgerald 2. Disability Sport: Historical Context Karen DePauw 3. Disability and Inclusion Policy Towards Physical Education and Youth Sport Andy Smith 4. Disability, Physical Education and sport: Some Critical Observations and Questions Len Barton 5. The Voices of Students with Disabilities: Are They Informing Inclusive Physical Education Practice? Donna Goodwin 6. 'We Want to Play Football' - Girls Experiencing Learning Disabilities and Their Footballing Experiences Annette Stride 7. Physical education as a normaliZing practice: Is there a space for disability sport? Hayley Fitzgerald and David Kirk 8. Picture this! Student co-researchers Aspley Wood School 9. The pedagogy of inclusive youth sport: working towards real solutions Pam Stevenson 10. Reflecting on Teaching, Learning and physical culture through Narrative Catherine Morrison 11. Are you a 'Parasite' Researcher? Researching disability and youth sport Hayley Fitzgerald 12. Future directions in youth sport and disability: development, aspirations and research Hayley Fitzgerald and Anne Jobling
Parents' Hopes and Expectations for Their Children's Future Occupations

Qualitative research has generated important insights into the intersection of social class, parental values and children's experiences of education and their role in the reproduction of inequalities. There has been less analytic engagement with parents' expectations and aspirations regarding their children's future occupations. Such expectations and aspirations have attracted much research and policy interest. Typically, analyses have been quantitative and focused on outcomes for children. Whilst parental expectations are deemed very influential for children's future occupational outcomes, there is relatively little evidence on the shaping of such expectations, or the ways in which future work and occupations are discussed between parents and children. This article reports on an analysis of parents' ideas about their children's future occupations and the contexts in which these ideas accrue meaning. Drawing on primary data from interviews with parents we explore diversity within, as well as across, social classes. First we explore parents' expectations and aspirations for their children's future occupations. Secondly we consider how parents see their own role in shaping such futures. The evidence highlights the salience of parents' own biographies and class backgrounds in shaping their orientations to, and manner of engagement with, their children's futures. Thirdly we briefly explore how parents' expectations and engagement with their children play out in class differentiated ways as their children approach early adulthood.
Molecular Characterization of the Iron-Hydroxamate Uptake System in Staphylococcus aureus

ABSTRACT To investigate iron uptake, a chromosomal locus containing three consecutive open reading frames, designated fhuC,fhuB, and fhuD, was identified inStaphylococcus aureus. Whereas the fhuC gene encodes an ATP-binding protein, fhuB and fhuDcode for ferrichrome permeases and thus resemble an ATP-binding cassette transporter. A fhuB knockout mutant showed impaired uptake of iron bound to the siderophores but not of ferric chloride, suggesting that this operon is specific for siderophore-mediated iron uptake.
Using general semantic information to help the terminology structuration

We report in this paper the results of a preliminairy experience on the relevance of general semantic information in the context of a terminology structuration. As resources supplying specialised semantic information in the domain of the studied documents are missing, we use general semantic information to structure a terminology. By exploiting a general synonymy dictionary, we attempt to infer synonymy links between candidate terms extracted from French technical document. The three rules designed allow us to propose synonymy links between complex candidate terms to an expert of the domain. An interesting part of the detected links have been validated as synonymy links. On the whole, it appeared that half of the overall links is useful. We have noted also that numerous errors are due to the polysemy of general language words, coarse-grained distinction of some meanings and the eli-sion of words widely used in the domain. Thus, we argue that general semantic information must be used with others resources such as morpho-syntactic links and is a useful aid for the terminology structuration.
Power emulation: Methodology and applications for HW/SW power optimization

Power profiling methods are indispensible in the power-aware design of HW/SW systems. By extending functional emulators with power estimation hardware, high-level power information can be derived during run-time, yielding a considerable speed-up as compared to simulation based approaches. A key enabler for the widespread use of the power emulation methodology is the automation of both power model creation and HDL adaptation. In this paper, we outline our system-level power emulation technique as well as its automatic power modeling and hardware adaptation. Furthermore, applications in the field of HW/SW power management are illustrated.
The Spiritual Lives of Bereaved Parents

This book describes how parents lose, find, or relocate spiritual anchors after the death of their child. It describes how ordinary people reconstruct their lives after their foundations have shifted, and how they make sense of their world after one of their centers of meaning has been removed. Klass grounds his descriptions of spirituality in his scholarly study of comparative religions, and in his two decades studying the lives of bereaved parents. He argues that continuing bonds with their dead children can give parents a new transcendent reality. Deceased children, like saints or bodhisattvas, can offer a bridge between the profane and sacred worlds, support parents as they find meaning in a world made forever poorer, and bind together a community adequate to parents' grief. The book reports Klass's clinical practice and his work as advisor to a bereaved parents self-help support group.
Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease

Objective. Aim of the study was to determine the prevalence of autoimmune thyroid disease, persistence of antithyroid antibodies, effect of gluten-free diet, and long-term outcome of thyroid function in pediatric patients with celiac disease (CD). Methods. 67 patients with CD aged from 1 year to 16 years were screened for thyroid antithyroperoxidase, antithyroglobulin and anti-TSH receptor antibodies, serum free triiodothyronine, free thyroxine, and thyroid-stimulating hormone (TSH) at diagnosis and during follow-up. Results. None of the patients had antithyroid antibodies at diagnosis. Antithyroid antibodies became positive in 16.4% of the patients (11/67) 2 to 3 years after the diagnosis of CD. Clinical hypothyroidism was observed only in 3 of 11 CD patients with positive antithyroid antibodies (27.2%). The antithyroid antibodies positive and negative patients did not differ significantly according to compliance to GFD (P > 0.05). A statistically significant difference was observed only in age, in which the patients with positive antithyroid antibodies were younger than the patients with negative antithyroid antibodies (P = 0.004). None of the patients had any change in their thyroid function and antibody profile during their follow-up. Conclusion. Antithyroid antibodies were detected in younger pediatric patients with CD and the prevalence of antithyroid antibodies did not correlate with the duration of gluten intake.
Automaticity and Achievement Goals: A Theoretical and Empirical Exploration of the Implications of Research on the Implicit for Capturing Students' Goals for Studying

This thesis examines whether implications from research in the field of implicit cognition apply to achievement goals via firstly an extensive re-assessment of the literature (Chapters 2 and 3) and then via a series of experiments (Chapters 4-7). Chapter one introduces the work, and outlines the rationale, aims and research. Chapter two is a critical examination of how achievement goals are currently defined and operationalized, and highlights the underlying assumptions that achievement goals are conscious and accessible. Chapter three challenges these assumptions by examining the literature on implicit cognition and nonconscious goal pursuit. Chapter three argues that as cognitive representations, there is a potential for achievement goals to be activated and operate nonconsciously, and that a methodology predominantly based on self-report is limited in the access it may provide to achievement goals. Chapter four designs, tests, and compares two original achievement goal implicit methods, the Valence IAT and Self/Other Referent IAT, with the Achievement Goal Questionnaire-Revised (AGQ-R, Elliot & Murayama, 2008), and found good internal consistency for both IATs but no significant correlations between IATs and AGQ-R. Chapter five compares the Valence IAT and the AGQ-R with students’ persistence behavior on an achievement task, and found both methods to be equally consistent with behavior. Chapter six tests whether achievement goals can be primed to influence subsequent achievement behavior, and found that persistence behavior differed significantly by priming condition in line with theorized patterns for performance and mastery goals. In Chapter seven, achievement goals are primed and compared directly with the Valence IAT and the AGQ-R, and both methods were found to be equally consistent with the primed goal. Chapter eight summarizes and concludes that this thesis provides the first in-depth theoretical and methodological exploration of the potential for nonconscious achievement goals in what is a promising field for continued study.