Miracle-dz/UniFAR-FTUs huggingface dataset:
Renoprotective Effect of Lactoferrin against Chromium-Induced Acute Kidney Injury in Rats: Involvement of IL-18 and IGF-1 Inhibition

Hexavalent chromium (CrVI) is a heavy metal widely used in more than 50 industries. Nephrotoxicity is a major adverse effect of chromium poisoning. The present study investigated the potential renoprotective effect of lactoferrin (Lf) against potassium dichromate (PDC)-induced acute kidney injury (AKI) in rats. Beside, because previous studies suggest that interlukin-18 (IL-18) and insulin-like growth factor-1 (IGF-1) play important roles in promoting kidney damage, the present work aimed to evaluate the involvement of these two cytokines in PDC model of AKI and in the potential renoprotective effect of lactoferrin. Adult male albino Wistar rats were pretreated with Lf (200mg/kg/day, p.o.) or (300mg/kg/day, p.o.); the doses that are usually used in the experiment studies, for 14 days followed by a single dose of PDC (15mg/kg, s.c.). PDC caused significant increase in serum urea, creatinine, and total protein levels. This was accompanied with decreased renal glutathione content, and increased renal malondialdehyde, IL-18, IL-4, nuclear factor kappa B (NFκB), IGF-1, and the phosphorylated form of forkhead box protein O1 (FoxO1) levels. Moreover, normal expression IFN-γ mRNA and enhanced expression of TNF-α mRNA was demonstrated in renal tissues. Histopathological investigations provoked deleterious changes in the renal tissues. Tubular epithelial hyperplasia and apoptosis were demonstrated immunohistochemically by positive proliferating cell nuclear antigen (PCNA), Bax, and Caspase-3 expression, respectively. Pretreatment of rats with Lf in both doses significantly corrected all previously mentioned PDC-induced changes with no significant difference between both doses. In conclusion, the findings of the present study demonstrated the involvement of oxidative stress, inflammatory reactions, tubular hyperplasia and apoptosis in PDC-induced AKI. It suggested a role of IL-18 through stimulation of IL-4-induced inflammatory pathway, and IGF-1 through triggering FoxO1-induced cell proliferation. Moreover, the study revealed that Lf protected the kidney against Cr-induced AKI in rats and significantly showed antioxidant, anti-inflammatory, and anti-proliferative properties with down-regulation of IL-18 and IGF-1.
IGF-1R/MDM2 Relationship Confers Enhanced Sensitivity to RITA in Ewing Sarcoma Cells

Ewing sarcoma is one of the most frequent bone cancers in adolescence. Although multidisciplinary therapy has improved the survival rate for localized tumors, a critical step is the development of new drugs to improve the long-term outcome of recurrent and metastatic disease and to reduce side effects of conventional therapy. Here, we show that the small molecule reactivation of p53 and induction of tumor cell apoptosis (RITA, NSC652287) is highly effective in reducing growth and tumorigenic potential of Ewing sarcoma cell lines. These effects occur both in the presence of wt-p53 as well as of mutant or truncated forms of p53, or in its absence, suggesting the presence of additional targets in this tumor histotype. Further experiments provided evidence that RITA modulates an important oncogenic mark of these cell lines, insulin-like growth factor receptor 1 (IGF-1R). Particularly, RITA causes downregulation of IGF-1R protein levels. MDM2 degradative activity is involved in this phenomenon. Indeed, inhibition of MDM2 function by genetic or pharmacologic approaches reduces RITA sensitivity of Ewing sarcoma cell lines. Overall, these data suggest that in the cell context of Ewing sarcoma, RITA may adopt additional mechanism of action besides targeting p53, expanding its field of application. Noteworthy, these results envisage the promising utilization of RITA or its derivative as a potential treatment for Ewing sarcomas. Mol Cancer Ther; 11(6); 1247–56. ©2012 AACR.
Environmental and historical imprints on beta diversity: insights from variation in rates of species turnover along gradients

A common approach for analysing geographical variation in biodiversity involves using linear models to determine the rate at which species similarity declines with geographical or environmental distance and comparing this rate among regions, taxa or communities. Implicit in this approach are weakly justified assumptions that the rate of species turnover remains constant along gradients and that this rate can therefore serve as a means to compare ecological systems. We use generalized dissimilarity modelling, a novel method that accommodates variation in rates of species turnover along gradients and between different gradients, to compare environmental and spatial controls on the floras of two regions with contrasting evolutionary and climatic histories: southwest Australia and northern Europe. We find stronger signals of climate history in the northern European flora and demonstrate that variation in rates of species turnover is persistent across regions, taxa and different gradients. Such variation may represent an important but often overlooked component of biodiversity that complicates comparisons of distance–decay relationships and underscores the importance of using methods that accommodate the curvilinear relationships expected when modelling beta diversity. Determining how rates of species turnover vary along and between gradients is relevant to understanding the sensitivity of ecological systems to environmental change.
A closed form solution to robust subspace estimation and clustering

We consider the problem of fitting one or more subspaces to a collection of data points drawn from the subspaces and corrupted by noise/outliers. We pose this problem as a rank minimization problem, where the goal is to decompose the corrupted data matrix as the sum of a clean, self-expressive, low-rank dictionary plus a matrix of noise/outliers. Our key contribution is to show that, for noisy data, this non-convex problem can be solved very efficiently and in closed form from the SVD of the noisy data matrix. Remarkably, this is true for both one or more subspaces. An important difference with respect to existing methods is that our framework results in a polynomial thresholding of the singular values with minimal shrinkage. Indeed, a particular case of our framework in the case of a single subspace leads to classical PCA, which requires no shrinkage. In the case of multiple subspaces, our framework provides an affinity matrix that can be used to cluster the data according to the sub-spaces. In the case of data corrupted by outliers, a closed-form solution appears elusive. We thus use an augmented Lagrangian optimization framework, which requires a combination of our proposed polynomial thresholding operator with the more traditional shrinkage-thresholding operator.
A Review of Cavity Design for Kerr Lens Mode-Locked Solid-State Lasers

We provide a critical review of the fundamental concepts of Kerr lens mode-locking (KLM), along with a detailed description of the experimental considerations involved in the realization of a mode-locked oscillator. In addition, we review recent developments that overcome inherent limitations and disadvantages in standard KLM lasers. Our review is aimed mainly at readers who wish to realize/maintain such an oscillator or for those who wish to better understand this major experimental tool.
Silver–Russell syndrome

Silver–Russell syndrome (SRS) is characterised by intrauterine growth restriction, poor postnatal growth, relative macrocephaly, triangular face, asymmetry and feeding difficulties. As many of these features are non-specific, clinical diagnosis of SRS remains difficult. Hypomethylation of the imprinting control region (ICR) 1 on chromosome 11p15 and maternal uniparental disomy (mUPD) for chromosome 7 are found in up to 60% and around 5–10% of patients with SRS, respectively. Patients with ICR1 hypomethylation are more likely to have classical features of SRS, including asymmetry; patients with mUPD7 are more likely to have learning difficulties, particularly speech problems, although these are usually mild. As features vary widely in severity, clinicians should have a low threshold for genetic investigation of patients with features suggestive of SRS.
Healthy Restrained Eaters Diminish Consummatory Food Reward and Inhibit Prepotent Feeding Responses: An EEG Study

Background: Some individuals with modest elevations in dietary restraint exhibit the ability to diminish consummatory and anticipatory food reward. In this paper we aim to identify the underlying mechanisms of food-specific cortical inhibition responses in restrained vs unrestrained eaters. Methods: Restrained (n = 43) and unrestrained eaters (n = 38) completed self-report surveys and a food- vs non-food Stroop task protocol with record of electroencephalography (EEG). Cortical rhythms and EEG ERPs were assessed. Results: Compared to their unrestrained peers, restrained eaters showed several differences in food task-related event-related potential (ERP) waveform presentation: ERP P300 component latency was significantly longer during food image viewing over the left parietal cortex (P3), and the amplitudes of the ERP P300 and LPP components were significantly greater over the right central electrode (C4) whilst responding to Stroop color-word cues. Food task-related conflict cue elicited ERP P300 amplitude correlated positively with eating restraint, and negatively with bioelectrical impedance assessed % body fat. Conclusions: Restrained eaters free of eating pathology attenuate conscious visual food cue processing and show enhanced executive brain functioning during late attentional processing despite the presence of distractor food cues. Our data propose robust executive governance as the primary underlying neurophysiological mechanism by which healthy restrained eaters diminish consummatory food reward and inhibit prepotent feeding responses.
The forced oscillation technique in clinical practice: methodology, recommendations and future developments

The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory mechanics. FOT employs small-amplitude pressure oscillations superimposed on the normal breathing and therefore has the advantage over conventional lung function techniques that it does not require the performance of respiratory manoeuvres. The present European Respiratory Society Task Force Report describes the basic principle of the technique and gives guidelines for the application and interpretation of FOT as a routine lung function test in the clinical setting, for both adult and paediatric populations. FOT data, especially those measured at the lower frequencies, are sensitive to airway obstruction, but do not discriminate between obstructive and restrictive lung disorders. There is no consensus regarding the sensitivity of FOT for bronchodilation testing in adults. Values of respiratory resistance have proved sensitive to bronchodilation in children, although the reported cutoff levels remain to be confirmed in future studies. Forced oscillation technique is a reliable method in the assessment of bronchial hyperresponsiveness in adults and children. Moreover, in contrast with spirometry where a deep inspiration is needed, forced oscillation technique does not modify the airway smooth muscle tone. Forced oscillation technique has been shown to be as sensitive as spirometry in detecting impairments of lung function due to smoking or exposure to occupational hazards. Together with the minimal requirement for the subject's cooperation, this makes forced oscillation technique an ideal lung function test for epidemiological and field studies. Novel applications of forced oscillation technique in the clinical setting include the monitoring of respiratory mechanics during mechanical ventilation and sleep.
Determinants of Auditor Expertise

In this study, we explore a view of expertise in which specific experiences and training create knowledge, and knowledge is combined with innate ability to perform specific audit tasks. Specifically, we test the extent to which we can explain cross-sectional variation in auditors' performance in several audit tasks using various types of knowledge and ability measures that have been identified in the psychology literature as important determinants of auditor expertise. We compare these results to the explanatory power of a simple measure of general audit experience. Our results indicate that, although more experienced auditors outperform less experienced auditors on average (and given our performance criteria), knowledge and innate ability provide a better explanation of variation in performance. Part of the motivation for this paper is to distinguish between general experience and expertise in the performance of information-processing tasks. Early studies of human information processing in accounting examined the effect of experience on performance in audit tasks (see, for example, Ashton and Brown [1980], Hamilton and Wright [1982], and Messier [1983]). Implicit in this research is the notion that ". a primary determinant of improved expertise . is experience" (Hamilton and Wright [1982, p. 757]). The reasoning behind this notion is that knowledge can be gained through experience and many audit tasks are knowl-
Cancer of the esophagus and esophagogastric junction

Previous American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) stage groupings for esophageal cancer have not been data driven or harmonized with stomach cancer. At the request of the AJCC, worldwide data from 3 continents were assembled to develop data‐driven, harmonized esophageal staging for the seventh edition of the AJCC/UICC cancer staging manuals.
A Study on the Information Integrated Mechanism of Tourist Destination Marketing System

Destination marketing system (DMS) is vital to both development of regional travel industry and international marketing. It is the internationally acknowledged advanced thinking of development of travel information. This article sets about the travel e-commerce, probes into the origin and development of DMS, make detailed analysis of the DMS of the travel from "information integration-positive feedback-function promoting", and considers DMS is a kind of dynamic network of co-operation system that renders to destination travel industry connected with every resource utilizing computer, modern communication technology and Internet. Some methods and approaches to solve these problems can also be found in this paper.
What explains the performance of Chinese exporting firms?

Drawing on the entry mode (EM) literature and the strategic tripod framework, we examine whether firm performance is influenced by its outward foreign direct investment (OFDI) mode, controlling other firm-, industry- and institution-specific factors. It is found that employing OFDI does not improve an exporting firm’s performance. This is not surprising as anecdotal evidence shows that many Chinese firms with OFDI have been making loss in the host country. This may indicate exporting firms employ OFDI to seek complementary and strategic resources/assets, not to improve immediate firm performance. Furthermore, firm performance is influenced by strategic assets, including technology-based capabilities and brands, at the firm level, industry entry barriers at the industry level and the home and host country institutional support at the country level.
Reconstruction of movement-related intracortical activity from micro-electrocorticogram array signals in monkey primary motor cortex

Subdural electrode arrays provide stable, less invasive electrocorticogram (ECoG) recordings of neural signals than multichannel needle electrodes. Accurate reconstruction of intracortical local field potentials (LFPs) from ECoG signals would provide a critical step for the development of a less invasive, high-performance brain–machine interface; however, neural signals from individual ECoG channels are generally coarse and have limitations in estimating deep layer LFPs. Here, we developed a high-density, 32-channel, micro-ECoG array and applied a sparse linear regression algorithm to reconstruct the LFPs at various depths of primary motor cortex (M1) in a monkey performing a reach-and-grasp task. At 0.2 mm beneath the cortical surface, the real and estimated LFPs were significantly correlated (correlation coefficient (r); 0.66 ± 0.11), and the r at 3.2 mm was still as high as 0.55 ± 0.04. A time-frequency analysis of the reconstructed LFP showed clear transition between resting and movements by the monkey. These methods would be a powerful tool with wide-ranging applicability in neuroscience studies.
Molecular Correlates and Recent Advancements in the Diagnosis and Screening of FMR1-Related Disorders

Fragile X syndrome (FXS) is the most common monogenic cause of intellectual disability and autism. Molecular diagnostic testing of FXS and related disorders (fragile X-associated primary ovarian insufficiency (FXPOI) and fragile X-associated tremor/ataxia syndrome (FXTAS)) relies on a combination of polymerase chain reaction (PCR) and Southern blot (SB) for the fragile X mental retardation 1 (FMR1) CGG-repeat expansion and methylation analyses. Recent advancements in PCR-based technologies have enabled the characterization of the complete spectrum of CGG-repeat mutation, with or without methylation assessment, and, as a result, have reduced our reliance on the labor- and time-intensive SB, which is the gold standard FXS diagnostic test. The newer and more robust triplet-primed PCR or TP-PCR assays allow the mapping of AGG interruptions and enable the predictive analysis of the risks of unstable CGG expansion during mother-to-child transmission. In this review, we have summarized the correlation between several molecular elements, including CGG-repeat size, methylation, mosaicism and skewed X-chromosome inactivation, and the extent of clinical involvement in patients with FMR1-related disorders, and reviewed key developments in PCR-based methodologies for the molecular diagnosis of FXS, FXTAS and FXPOI, and large-scale (CGG)n expansion screening in newborns, women of reproductive age and high-risk populations.
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins

Chaperone protein BiP binds to Ire1 and dissociates in response to endoplasmic reticulum (ER) stress. However, it remains unclear how the signal transducer Ire1 senses ER stress and is subsequently activated. The crystal structure of the core stress-sensing region (CSSR) of yeast Ire1 luminal domain led to the controversial suggestion that the molecule can bind to unfolded proteins. We demonstrate that, upon ER stress, Ire1 clusters and actually interacts with unfolded proteins. Ire1 mutations that affect these phenomena reveal that Ire1 is activated via two steps, both of which are ER stress regulated, albeit in different ways. In the first step, BiP dissociation from Ire1 leads to its cluster formation. In the second step, direct interaction of unfolded proteins with the CSSR orients the cytosolic effector domains of clustered Ire1 molecules.
Parkinson's disease and D 1 dopamine receptors

This article reviews the role of the D1-like dopamine receptors in Parkinson's disease (PD), an idea supported by the location of D 1 receptors in key aspects of basal ganglia circuitry. The initial disappointing results with available partial D 1 agonists have been replaced by optimism as newer full D1 agonists have been shown to be the only class of drugs that can decrease parkinsonism in primates to a degree comparable to levodopa. Most of the available D 1 agonists, however, have been plagued by several problems, including poor bioavailability due, at least in part, to the necessity of a catechol function. Three other development issues that have hampered some members of this class are tolerance, hypotension and seizures, although some of the newer drugs entering early development may have escaped these problems. Finally, scientific advances have suggested that therapeutic profiles may be improved either by targeting only one of the two D 1 -like receptors or by developing drugs that can activate selectively only some D1-mediated functions. These examples suggest that it is highly likely that the immense therapeutic potential of D 1 agonists will be realized both in PD and several other important CNS disorders before the end of the decade.
Insights into internal effects of common-envelope evolution using the extended Kepler mission

We present an analysis of the binary and physical parameters of a unique pulsating white dwarf with a main-sequence companion, SDSS J1136+0409, observed for more than 77 d during the first pointing of the extended Kepler mission: K2 Campaign 1. Using new groundbased spectroscopy, we show that this post-common-envelope binary has an orbital period of 6.89760103(60) h, which is also seen in the photometry as a result of Doppler beaming and ellipsoidal variations of the secondary. We spectroscopically refine the temperature of the white dwarf to 12 330 ± 260 K and its mass to 0.601 ± 0.036 M. We detect seven independent pulsation modes in the K2 light curve. A preliminary asteroseismic solution is in reasonable agreement with the spectroscopic atmospheric parameters. Three of the pulsation modes are clearly rotationally split multiplets, which we use to demonstrate that the white dwarf is not synchronously rotating with the orbital period but has a rotation period of 2.49 ± 0.53 h. This is faster than any known isolated white dwarf, but slower than almost all white dwarfs measured in non-magnetic cataclysmic variables, the likely future state of this binary.
Advanced eager scheduling for Java‐based adaptive parallel computing

Javelin 3 is a software system for developing large‐scale, fault‐tolerant, adaptively parallel applications. When all or part of their application can be cast as a master–worker or branch‐and‐bound computation, Javelin 3 frees application developers from concerns about inter‐processor communication and fault tolerance among networked hosts, allowing them to focus on the underlying application. The paper describes a fault‐tolerant task scheduler and its performance analysis. The task scheduler integrates work stealing with an advanced form of eager scheduling. It enables dynamic task decomposition, which improves host load‐balancing in the presence of tasks whose non‐uniform computational load is evident only at execution time. Speedup measurements are presented of actual performance on up to 1000 hosts. We analyze the expected performance degradation due to unresponsive hosts, and measure actual performance degradation due to unresponsive hosts. Copyright © 2005 John Wiley & Sons, Ltd.