Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel Method for Improving the Capacity in 5G Mobile Networks Combining NOMA and OMA

Non-Orthogonal Multiple Access (NOMA) has been suggested as one of the technologies to be implemented in the fifth generation - 5G - mobile networks. NOMA helps increasing the capacity by offering a more effective use of the available resources, but it also intentionally introduces interference in the transmitted signal. This means that higher signal-to-interference-plus-noise ratio (SINR) values are required to decode the received signal, in comparison to orthogonal multiple access (OMA). Since it is unrealistic to consider a system working only with NOMA because not all the users (UEs) will meet the requirements to use this multiple access (MA) method, a hybrid MA system combining NOMA with OMA is expected. In this paper we present the performance evaluation of a hybrid MA system combined with a novel pairing algorithm based on modulation and coding scheme (MCS) adjustment and extra transmission power (Tx power) allocation. The purpose of such pairing approach is to help the NOMA UEs reach the needed SINR while improving the overall system capacity. Moreover, we use mmWave for the signal propagation to further increase the system capacity. The results show that such a system with an extra Tx power between 14% and 19% of the total Tx power for OMA, can offer the best tradeoff with a system capacity gain up to 1.78-fold for a total of 6.7 Gbps, an average 3.31-fold increase for the UEs bit rate, and a block error rate (BLER) below 10%.
Comprehensive Analysis of Secondary Dental Root Canal Infections: A Combination of Culture and Culture-Independent Approaches Reveals New Insights

Persistence of microorganisms or reinfections are the main reasons for failure of root canal therapy. Very few studies to date have included culture-independent methods to assess the microbiota, including non-cultivable microorganisms. The aim of this study was to combine culture methods with culture-independent cloning methods to analyze the microbial flora of root-filled teeth with periradicular lesions. Twenty-one samples from previously root-filled teeth were collected from patients with periradicular lesions. Microorganisms were cultivated, isolated and biochemically identified. In addition, ribosomal DNA of bacteria, fungi and archaea derived from the same samples was amplified and the PCR products were used to construct clone libraries. DNA of selected clones was sequenced and microbial species were identified, comparing the sequences with public databases. Microorganisms were found in 12 samples with culture-dependent and -independent methods combined. The number of bacterial species ranged from 1 to 12 in one sample. The majority of the 26 taxa belonged to the phylum Firmicutes (14 taxa), followed by Actinobacteria, Proteobacteria and Bacteroidetes. One sample was positive for fungi, and archaea could not be detected. The results obtained with both methods differed. The cloning technique detected several as-yet-uncultivated taxa. Using a combination of both methods 13 taxa were detected that had not been found in root-filled teeth so far. Enterococcus faecalis was only detected in two samples using culture methods. Combining the culture-dependent and –independent approaches revealed new candidate endodontic pathogens and a high diversity of the microbial flora in root-filled teeth with periradicular lesions. Both methods yielded differing results, emphasizing the benefit of combined methods for the detection of the actual microbial diversity in apical periodontitis.
Microparticles-entrapped micelles: a novel delivery system to improve solubility and dissolution rate of poorly water-soluble valsartan

Abstract Surfactants are routinely included in tablets during wet or dry granulations or along with directly compressible vehicles to improve wetting, disintegration and dissolution. Besides this micellar solubilization can improve permeability of poorly soluble drugs via gastrointestinal tract membranes thereby enhancing oral bioavailability. Microparticle-entrapped micelles (MEM) technology is a novel method of incorporating surfactants in tablets for improving in vitro and in vivo performance of poorly water-soluble drugs. Valsartan (VAL) was solubilized in cremophor EL micelles at cloud point temperature; lactose was dissolved in micellar dispersion and the dispersion was directly spray-dried to obtain solid product, which was subsequently converted into tablets using suitable excipients. VAL tablets produced by applying MEM technology improved dissolution performance of valsartan tablets. These tablets exhibited superior dissolution rate over controls and marketed tablets in all media employed irrespective of pH conditions and composition.
Modeling and combining evidence provided by document relationships using probabilistic argumentation systems

Previous research has shown that hypertext links may be a useful source of evidence for document contents and relevance, but these evidence are rather difficult to represent and combine. This paper introduces a new and sound model for representing and handling hypertext links in IR. This model is based on ctProbabilistic Argumentation Systems )), a technique which combines logic and probability to handle uncertainty. Some experiments show the potential of this approach, which requires no ad-hoc parameters.
A study of the effects of the process parameters on the characteristics of photochemical flexographic printing plates

Inconsistency in flexographic platemaking techniques was perceived to influence the print quality and consistency. The results of a factorial designed experiment created to establish which platemaking factors had a significant influence on the flexographic printing quality are reported in this paper. The objective of the experiment was not only to define the optimum platemaking technique, but also to improve the understanding of the characteristics and properties of the photopolymer printing plate and to identify the key interacting factors which have the most significant effect on print quality and consistency. Various statistical methods were employed for the design of the experiment and for the interpretation of experimental data generated. The results of the investigation have been used to fine‐tune the flexographic platemaking techniques to significantly manipulate the properties for the end‐use application to enhance printing performance and consistency of the plates.
Diffusion Tensor Imaging of the Normal Pediatric Spinal Cord Using an Inner Field of View Echo-Planar Imaging Sequence

BACKGROUND AND PURPOSE: DTI in the brain has been well established, but its application in the spinal cord, especially in pediatrics, poses several challenges. The small cord size has inherent low SNR of the diffusion signal intensity, respiratory and cardiac movements induce artifacts, and EPI sequences used for obtaining diffusion indices cause eddy-current distortions. The purpose of this study was to 1) evaluate the accuracy of cervical spinal cord DTI in children using a newly developed iFOV sequence with spatially selective 2D-RF excitations, and 2) examine reproducibility of the DTI measures. MATERIALS AND METHODS: Twenty-five typically developing subjects were imaged twice using a 3T scanner. Axial DTI images of the cervical spinal cord were acquired with this sequence. After motion correction, DTI indices were calculated using regions of interest manually drawn at every axial section location along the cervical spinal cord for both acquisitions. Various DTI indices were calculated: FA, AD, RD, MD, RA, and VR. Geometric diffusion measures were also calculated: Cp, Cl, and Cs. RESULTS: The following average values for each index were obtained: FA = 0.50 ± 0.11; AD = 0.97 ± 0.20 × 10−3mm2/s; RD = 0.41 ± 0.13 × 10−3mm2/s; MD = 0.59 ± 0.15 × 10−3mm2/s; RA = 0.35 ± 0.08; VR = 0.03 ± 0.00; Cp = 0.13 ± 0.07; Cl = 0.29 ± 0.09; and Cs = 0.58 ± 0.11. The reproducibility tests showed moderate to strong ICC in all subjects for all DTI parameters (ICC>0.72). CONCLUSIONS: This study showed that accurate and reproducible DTI parameters can be estimated in the pediatric cervical spinal cord using an iFOV EPI sequence.
Fenoldopam Preconditioning: Role of Heme Oxygenase-1 in Protecting Human Tubular Cells and Rodent Kidneys Against Cold-Hypoxic Injury

Background. Kidneys from brain-dead donors are cold preserved until transplanted. However, prolonged cold storage can contribute to allograft failure. Studies suggest that donor preconditioning with dopaminergics may reduce cold-ischemic transplant injury, but whether heme oxygenase (HO)-1 induction is an underlying mechanism is not known. Objective. To test whether preconditioning with fenoldopam (FD) induce HO-1 and protect kidneys against cold storage injury and whether HO-1 plays a role in protection. Method. We used human renal proximal tubular epithelial cells, rat kidney transplants, and HO-1(−/−) null mice kidneys. Results. FD preconditioning of cells for 4 hr significantly protected against cell death from 24-hr cold hypoxia and was associated with a dose-dependent increase in HO-1 expression. In a syngeneic rat kidney transplant model, FD preconditioning for 18 hr markedly increased kidney HO-1 expression and protected kidneys against 24-hr cold-ischemic transplant injury. To test the role of HO-1, renal proximal tubular epithelial cells were treated with HO-1 small interfering RNA, followed by FD-preconditioning. Small interfering RNA inhibited the HO-1 messenger RNA expression and reversed the FD protection. Suspension of kidneys of HO-1(−/−) null and wild-type mice preconditioned with FD or saline were subjected to 24- and 48-hr cold storage. N-acetyl glucosaminidase, a specific tubular injury marker, was significantly lower in FD-preconditioned wild-type kidneys, but not in HO-1 null kidneys, suggesting a role for HO-1 in FD's preconditioning. Conclusion. Our data suggest HO-1 induction as an underlying mechanism for FD preconditioning and support the idea of testing FD preconditioning in the clinical setting. Studies are required to determine the optimum FD-preconditioning protocol.
Casein kinase I δ/ɛ phosphorylates topoisomerase IIα at serine-1106 and modulates DNA cleavage activity

We previously reported that phosphorylation of topoisomerase (topo) IIα at serine-1106 (Ser-1106) regulates enzyme activity and sensitivity to topo II-targeted drugs. In this study we demonstrate that phosphorylation of Ser-1106, which is flanked by acidic amino acids, is regulated in vivo by casein kinase (CK) Iδ and/or CKIɛ, but not by CKII. The CKI inhibitors, CKI-7 and IC261, reduced Ser-1106 phosphorylation and decreased formation of etoposide-stabilized topo II–DNA cleavable complex. In contrast, the CKII inhibitor, 5,6-dichlorobenzimidazole riboside, did not affect etoposide-stabilized topo II–DNA cleavable complex formation. Since, IC261 specifically targets the Ca2+-regulated isozymes, CKIδ and CKIɛ, we examined the effect of down-regulating these enzymes on Ser-1106 phosphorylation. Down-regulation of these isozymes with targeted si-RNAs led to hypophosphorylation of the Ser-1106 containing peptide. However, si-RNA-mediated down-regulation of CKIIα and α′ did not alter Ser-1106 phosphorylation. Furthermore, reduced phosphorylation of Ser-1106, observed in HRR25 (CKIδ/ɛ homologous gene)-deleted Saccharomyces cerevisiae cells transformed with human topo IIα, was enhanced following expression of human CKIɛ. Down-regulation of CKIδ and CKIɛ also led to reduced formation of etoposide stabilized topo II–DNA cleavable complex. These results provide strong support for an essential role of CKIδ/ɛ in phosphorylating Ser-1106 in human topo IIα and in regulating enzyme function.
Endothelial glycocalyx dimensions are reduced in growing collateral arteries and modulate leucocyte adhesion in arteriogenesis

During collateral artery growth, monocytes adhere to the endothelium and secrete cytokines from the perivascular space promoting arteriogenesis. Recently, the endothelial glycocalyx has been shown to modulate leucocyte infiltration in atherogenic regions. The role of this endothelial surface coating in arteriogenesis, however, has not been investigated so far. We now report that local plasma levels of hyaluronic acid are specifically increased in collateral arterial blood of coronary artery disease patients and hypothesized that components of the endothelial glycocalyx are shed during arteriogenesis, resulting in decreased glycocalyx dimensions and an increased leucocyte extravasation. In a rabbit model of femoral artery ligation, electron microscopy revealed a decrease in glycocalyx dimensions in collateral arteries compared with quiescent anastomoses (67.5 ± 47.2 nm versus 101.0 ± 11.3 nm; P < 0.001). This decrease was correlated with a higher number of perivascular macrophages around collateral arteries. The additional glycocalyx perturbation by local hyaluronidase infusion almost completely removed the endothelial surface layer and temporarily stimulated leucocyte accumulation in the perivascular space. However, complete perturbation of the glycocalyx by hyaluronidase infusion resulted in a significant attenuation of collateral artery growth assessed by microsphere‐based perfusion measurements (ml/min/100 mmHg: hyaluronidase: 27.5 ± 3.5; Controls: 47.1 ± 3.83; P < 0.001) and a lower percentage of actively proliferating vascular smooth muscle cells. A decreased expression of the shear‐stress regulated pro‐arteriogenic genes eNOS and TGF‐β1 suggests an impaired mechanotransduction as the underlying mechanisms. For the first time, we describe the role of the endothelial glycocalyx in collateral artery growth. Although complete abrogation led to attenuated arteriogenesis, shedding of glycocalyx components is observed during collateral artery growth.
Waveguiding in air with left-handed material

Symmetric air waveguide and antisymmetric air waveguide made with left-handed material (LHM) cladding are constructed. Guided modes in the two kinds of air waveguides are studied on condition that the permittivity and permeability of LHM are simultaneously negative. When absolute value of refraction of cladding is less than that of air, fast modes and slow modes are possible to exist at the same time; when absolute value of refraction of cladding is more than that of air, only slow modes could exist.
Renal Hemodynamic and Natriuretic Effects of Concomitant Angiotensin-Converting Enzyme and Neutral Endopeptidase Inhibition in Men

This double-blind placebo-controlled study was designed to investigate the acute and sustained hormonal, renal hemodynamic, and tubular effects of concomitant ACE and neutral endopeptidase (NEP) inhibition by omapatrilat, a vasopeptidase inhibitor, in men. Thirty-two normotensive subjects were randomized to receive a placebo, omapatrilat (40 or 80 mg), or the fosinopril/hydrochlorothiazide (FOS/HCTZ; 20 and 12.5 mg, respectively) fixed combination for 1 week. Blood pressure, renal hemodynamics, urinary electrolytes and atrial natriuretic peptide excretion, and several components of the renin-angiotensin system were measured for 6 hours on days 1 and 7 of drug administration. When compared with the placebo and the FOS/HCTZ combination, omapatrilat induced a significant decrease in plasma angiotensin II levels (P <0.001 versus placebo;P <0.05 versus FOS/HCTZ) and an increase in urinary atrial natriuretic peptide excretion (P <0.01). These hormonal effects were associated with a significant fall in blood pressure (P <0.01) and a marked renal vasodilatation, but with no significant changes in glomerular filtration rate. The FOS/HCTZ markedly increased urinary sodium excretion (P <0.001). The acute natriuretic response to FOS/HCTZ was significantly greater than that observed with omapatrilat (P <0.01). Over 1 week, however, the cumulative sodium excretion induced by both doses of omapatrilat (P <0.01 versus placebo) was at least as great as that induced by the dose of FOS/HCTZ (P =NS versus FOS/HCTZ). In conclusion, the results of the present study in normal subjects demonstrate that omapatrilat has favorable renal hemodynamic effects. Omapatrilat combines potent ACE inhibition with a sustained natriuresis, which explains its well-documented potent antihypertensive efficacy.
PERFORMANCE ON FIGURE GROUND PERCEPTION FOLLOWING STROKE INDUCED HEMIPLEGIA: A COMPAIRSON OF PRE-AND POST-REHABILITATION WITH THE NEUROLOGICALLY UNIMPAIRED

This article compares performance times on the Figure Ground Perception (FGP) of the Sensory Integration and Praxis Tests (SIPT) in persons with stroke-induced hemiplegia and unimpaired older persons. Two hundred and twelve right dominant persons with hemiplegia on admission and discharge from comprehensive rehabilitation and 321 neurologically unimpaired persons in the community were evaluated on the FGP subtests of the SIPT. There were significant differences in performance between unimpaired persons and those with hemiplegia following a stroke. Among the persons with stroke-induced hemiplegia, performance on discharge was significantly better than on admission across all five FGP subtests. Age, sex, and severity of hemiplegia also affected performance on specific subtests; the influence of laterality was significant in persons with right hemispheric lesions; and persons with Wernicke's aphasia performed more poorly. Although further investigation is clearly needed, the association of increasing age (particularly males 75 years and over), severity of hemiplegia, and presence of aphasia on FGP performance suggest that these factors should be considered in the development of rehabilitation programs for stroke patients.
Different Transportation and Maintenance Strategies for Offshore Wind Farms

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A Novel Privacy Preserving Location-Based Service Protocol With Secret Circular Shift for K-NN Search

Location-based service (LBS) is booming up in recent years with the rapid growth of mobile devices and the emerging of cloud computing paradigm. Among the challenges to establish LBS, the user privacy issue becomes the most important concern. A successful privacy-preserving LBS must be secure and provide accurate query [e.g., -nearest neighbor (NN)] results. In this work, we propose a private circular query protocol (PCQP) to deal with the privacy and the accuracy issues of privacy-preserving LBS. The protocol consists of a space filling curve and a public-key homomorphic cryptosystem. First, we connect the points of interest (POIs) on a map to form a circular structure with the aid of a Moore curve. And then the homomorphism of Paillier cryptosystem is used to perform secret circular shifts of POI-related information (POI-info), stored on the server side. Since the POI-info after shifting and the amount of shifts are encrypted, LBS providers (e.g., servers) have no knowledge about the user's location during the query process. The protocol can resist correlation attack and support a multiuser scenario as long as the predescribed secret circular shift is performed before each query; in other words, the robustness of the proposed protocol is the same as that of a one-time pad encryption scheme. As a result, the security level of the proposed protocol is close to perfect secrecy without the aid of a trusted third party and simulation results show that the k-NN query accuracy rate of the proposed protocol is higher than 90% even when is large.
Temperature measurement and visualization study of liquid helium cavitation flow through Venturi channel

In the present experiment, the cavitation flow of liquid helium is generated downstream of the throat in a Venturi channel with a rectangular cross section. We measured the temperature variation induced by cavitation, and took visualization pictures of cavitation flow to examine the general feature of liquid helium cavitation flow. It is found that there are some definite differences in the appearance of cavitation between He I and He II flows, and that the phase transition from He I to He II is sometimes induced because of the temperature drop in cavitating He I flow. In He I, large temperature drop produced in the vicinity of the throat rapidly becomes diminishes with the distance from the throat, while in He II it still develops in the upper half of the downstream region of the channel. Visualization pictures show that in the case of He I the bubbly portion is composed of numerous small vapor bubbles, and then in the downstream region they disappear rapidly. But in He II the bubbly flow portion is comp.
Modified RNA-seq method for microbial community and diversity analysis using rRNA in different types of environmental samples

RNA-seq-based SSU (small subunit) rRNA (ribosomal RNA) analysis has provided a better understanding of potentially active microbial community within environments. However, for RNA-seq library construction, high quantities of purified RNA are typically required. We propose a modified RNA-seq method for SSU rRNA-based microbial community analysis that depends on the direct ligation of a 5’ adaptor to RNA before reverse-transcription. The method requires only a low-input quantity of RNA (10–100 ng) and does not require a DNA removal step. The method was initially tested on three mock communities synthesized with enriched SSU rRNA of archaeal, bacterial and fungal isolates at different ratios, and was subsequently used for environmental samples of high or low biomass. For high-biomass salt-marsh sediments, enriched SSU rRNA and total nucleic acid-derived RNA-seq datasets revealed highly consistent community compositions for all of the SSU rRNA sequences, and as much as 46.4%-59.5% of 16S rRNA sequences were suitable for OTU (operational taxonomic unit)-based community and diversity analyses with complete coverage of V1-V2 regions. OTU-based community structures for the two datasets were also highly consistent with those determined by all of the 16S rRNA reads. For low-biomass samples, total nucleic acid-derived RNA-seq datasets were analyzed, and highly active bacterial taxa were also identified by the OTU-based method, notably including members of the previously underestimated genus Nitrospira and phylum Acidobacteria in tap water, members of the phylum Actinobacteria on a shower curtain, and members of the phylum Cyanobacteria on leaf surfaces. More than half of the bacterial 16S rRNA sequences covered the complete region of primer 8F, and non-coverage rates as high as 38.7% were obtained for phylum-unclassified sequences, providing many opportunities to identify novel bacterial taxa. This modified RNA-seq method will provide a better snapshot of diverse microbial communities, most notably by OTU-based analysis, even communities with low-biomass samples.