Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Graduated Response Anti‐Piracy Laws on Music Sales: Evidence from an Event Study in France

type="main"> Despite the problem that filesharing poses to the creative industries, there is little research on the effectiveness of governmental anti-piracy policies. This study analyzes how the HADOPI graduated response law in France affected digital music sales. Using a panel of sales data from the four major labels, we applied a difference-in-difference approach, comparing sales trends in France to a control group of European countries. We find that increased consumer awareness of HADOPI caused French iTunes music sales to increase by 22-25%. The observed sales increase is larger in high piracy genres than low piracy ones, strengthening the causal interpretation of our results.
Home Search Collections Journals About Contact us My IOPscience Investigation of mixed ion fields in the forward direction for 220 . 5 MeV / u helium ion beams : comparison between water and PMMA targets

Currently there is a rising interest in helium ion beams for radiotherapy. For benchmarking of the physical beam models used in treatment planning, there is a need of experimental data on the composition and spatial distribution of mixed ion fields. Of particular interest are the attenuation of the primary helium ion fluence and the buildup of secondary hydrogen ions due to nuclear interactions. The aim of this work was to provide such data with an enhanced precision. Moreover, the validity and limits of the mixed ion field equivalence between water and PMMA targets were investigated. The experiments with a 220.5 MeV/u helium ion pencil beam were performed at the Heidelberg Ion-Beam Therapy Center in Germany. The compact detection system for ion tracking and identification was solely based on positionsensitive semiconductor detectors Timepix. In comparison to standard techniques, this system is two orders of magnitude smaller, and it provides higher precision and flexibility. The numbers of outgoing helium and hydrogen ions per primary helium ion, as well as the lateral particle distributions were quantitatively investigated in the forward direction behind water and PMMA targets with 5.2-18 cm water equivalent thickness (WET). Comparing water and PMMA targets with same WET, we found that significant differences in the amount of outgoing helium ions, hydrogen ions and in the lateral particle distributions arise for target thicknesses above 10 cm WET. The experimental results concerning hydrogen ions emerging from the targets were reproduced reasonably well by the Monte Carlo simulations using the FLUKA code. Concerning the amount of outgoing helium ions, significant differences of 3-15% were found between experiments and simulations. We conclude that if PMMA is used in place of water in dosimetry, differences in the dose distributions could arise close to the edges of the field, in particular for deep seated targets.
Molecular Subtypes, Apoptosis and Proliferation Status in Indonesian Diffuse Large B-Cell Lymphoma Cases

Objective: The diffuse large B-cell lymphoma (DLBCL) has two major molecular subtypes, germinal center B-cell-like (GCB) and non-GCB. These have differing behavior which affects overall patient survival. However, immunohistochemistry based molecular subtyping of Indonesian DLBCLs has been limited. This was the focus of the present study, with a focus of attention on the apoptotic index (AI) and the proliferation index (PI) of the two molecular subtypes. Materials and Methods: During the study period of 3.5 years, a total of 98 cases of DLBCL were identified. Molecular subtypes and PI were determined by immunohistochemistry and TUNEL method was used to determine the AI. Result: GCB accounted for 31 cases (31.6%) and non-GCB the remainder (68.4%). Gender showed a slight male predominance (54 cases, 55.1%), with a higher incidence in the extra-nodal region (57 cases, 58.2%). The AI and PI were significantly higher in GCB (p<0.001 in the Mann-Whitney test) and a Spearman correlation coefficient test showed that PI was positively correlated with AI (r=0.673, p<0.001). Conclusion: The findings indicate that the non-GCB subtype is more common than GCB in Indonesian DLBCL. GCB features significantly higher PI and AI, which themselves appear linked.
Genotyping Cryptosporidium andersoni in Cattle in Shaanxi Province, Northwestern China

The present study examined the prevalence and genotypes of Cryptosporidium andersoni in cattle in Shaanxi province, China. A total of 2071 fecal samples (847 from Qinchuan cattle and 1224 from dairy cattle) were examined for the presence of Cryptosporidium oocysts, and 70 samples (3.4%) were C. andersoni-positive and those positive samples were identified by PCR amplification of the small subunit ribosomal RNA (SSU rRNA) and the Cryptosporidium oocyst wall protein (COWP) genes. C. andersoni was the only species found in the examined cattle in this province. Fifty-seven C. andersoni isolates were characterized into 5 MLST subtypes using multilocus sequence typing analysis, including a new subtype in the native beef breed Qinchuan cattle. All of these C. andersoni isolates presented a clonal genetic structure. These findings provide new insights into the genetic structure of C. andersoni isolates in Shaanxi province and basic data of Cryptosporidium prevalence status, which in turn have implications for controlling cryptosporidiosis in this province.
Modeling the Structure of RNA Molecules with Small-Angle X-Ray Scattering Data

We propose a novel fragment assembly method for low-resolution modeling of RNA and show how it may be used along with small-angle X-ray solution scattering (SAXS) data to model low-resolution structures of particles having as many as 12 independent secondary structure elements. We assessed this model-building procedure by using both artificial data on a previously proposed benchmark and publicly available data. With the artificial data, SAXS-guided models show better similarity to native structures than ROSETTA decoys. The publicly available data showed that SAXS-guided models can be used to reinterpret RNA structures previously deposited in the Protein Data Bank. Our approach allows for fast and efficient building of de novo models of RNA using approximate secondary structures that can be readily obtained from existing bioinformatic approaches. We also offer a rigorous assessment of the resolving power of SAXS in the case of small RNA structures, along with a small multimetric benchmark of the proposed method.
Less is more? How demographic sample weights can improve public opinion estimates based on Twitter data.

An important limitation in previous studies of political behavior using Twitter data is the lack of information about the sociodemographic characteristics of individual users. This paper addresses this challenge by developing new machine learning methods that will allow researchers to estimate the age, gender, race, party af-ﬁliation, propensity to vote, and income of any Twitter user in the U.S. with high accuracy. The training dataset for these classiﬁers was obtained by matching a massive dataset of 1 billion geolocated Twitter messages with voting registration records and estimates of home values across 15 different states, resulting in a sample of nearly 250,000 Twitter users whose sociodemographic traits are known. I illustrate the value of these new meth-ods with two applications. First, I explore how attention to different candidates in the 2016 presidential primary election varies across demographic groups within a panel of randomly selected Twitter users. I argue that these covariates can be used to adjust estimates of sentiment towards political actors based on Twitter data, and provide a proof of concept using presidential approval. Second, I examine whether social media can reduce inequalities in potential exposure to political messages. In particular, I show that retweets (a proxy for inadvertent exposure) have a large equalizing effect in access to information.
Do Daily Scrums Have to Take Place Each Day? A Case Study of Customized Scrum Principles at an E-commerce Company

Agile development approaches, such as Scrum, continue to gain importance in today's world. Since previous research has predominantly treated development approaches as a black box, we answer the call for empirical research concerning adoption of agile methods. The study's aim is to assess the adoption or adaption of Scrum principles at an e-commerce company. The findings of our in-depth single case study reveal that not all Scrum principles are suitable in each context. By discussing the reasons for adopting or adapting the principles, we contribute to a deeper understanding of agile methods and help to open the black box of development approaches in information systems research. The in-depth insights gained at our case company provide practitioners a useful reference for adapting agile methods to their specific contexts.
Antibody Kinetics and Response to Routine Vaccinations in Infants Born to Women Who Received an Investigational Trivalent Group B Streptococcus Polysaccharide CRM197-Conjugate Vaccine During Pregnancy

Group B Streptococcus (GBS)–specific antibodies were detectable in 3-month-old infants of mothers having received an investigational trivalent GBS vaccine during pregnancy. Maternal GBS vaccination did not have a clinically meaningful impact on immune responses to diphtheria or pneumococcal pediatric vaccination.
Acoustic resonance characterization of low-wattage metal-halide lamps under low-frequency square-waveform operation

In this paper a study about acoustic resonance in low-wattage metal halide lamps is presented. The lamps are supplied with a low frequency square waveform on which a high frequency sinusoidal ripple waveform is superposed. The goal is to emulate the same current waveform produced by low frequency electronic ballasts. In this way, the acoustic resonances appearing in the lamp can be characterized against ripple amplitude and frequency. Different lamp's manufacturers and aging periods are used. The obtained results are intended to be employed in further reliable designs of low frequency electronic ballasts.
Synthesis, structural characterization and computational studies of catena-poly[chlorido[μ3-(pyridin-1-ium-3-yl)phosphonato-κ3O:O':O'']zinc(II)].

Coordination polymers are constructed from two basic components, namely metal ions, or metal-ion clusters, and bridging organic ligands. Their structures may also contain other auxiliary components, such as blocking ligands, counter-ions and nonbonding guest or template molecules. The choice or design of a suitable linker is essential. The new title zinc(II) coordination polymer, [Zn(C5H5NO3P)Cl]n, has been hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction and vibrational spectroscopy (FT-IR and FT-Raman). Additionally, computational methods have been applied to derive quantitative information about interactions present in the solid state. The compound crystallizes in the monoclinic space group C2/c. The four-coordinated ZnII cation is in a distorted tetrahedral environment, formed by three phosphonate O atoms from three different (pyridin-1-ium-3-yl)phosphonate ligands and one chloride anion. The ZnII ions are extended by phosphonate ligands to generate a ladder chain along the [001] direction. Adjacent ladders are held together via N-H.O hydrogen bonds and offset face-to-face π-π stacking interactions, forming a three-dimensional supramolecular network with channels. As calculated, the interaction energy between the neighbouring ladders is -115.2 kJ mol-1. In turn, the cohesive energy evaluated per asymmetric unit-equivalent fragment of a polymeric chain in the crystal structure is -205.4 kJ mol-1. This latter value reflects the numerous hydrogen bonds stabilizing the three-dimensional packing of the coordination chains.
When Local Extinction and Colonization of River Fishes Can Be Predicted by Regional Occupancy: the Role of Spatial Scales

Background Predicting which species are likely to go extinct is perhaps one of the most fundamental yet challenging tasks for conservation biologists. This is particularly relevant for freshwater ecosystems which tend to have the highest proportion of species threatened with extinction. According to metapopulation theories, local extinction and colonization rates of freshwater subpopulations can depend on the degree of regional occupancy, notably due to rescue effects. However, relationships between extinction, colonization, regional occupancy and the spatial scales at which they operate are currently poorly known. Methods And Findings: We used a large dataset of freshwater fish annual censuses in 325 stream reaches to analyse how annual extinction/colonization rates of subpopulations depend on the regional occupancy of species. For this purpose, we modelled the regional occupancy of 34 fish species over the whole French river network and we tested how extinction/colonization rates could be predicted by regional occupancy described at five nested spatial scales. Results show that extinction and colonization rates depend on regional occupancy, revealing existence a rescue effect. We also find that these effects are scale dependent and their absolute contribution to colonization and extinction tends to decrease from river section to larger basin scales. Conclusions In terms of management, we show that regional occupancy quantification allows the evaluation of local species extinction/colonization dynamics and reduction of local extinction risks for freshwater fish species implies the preservation of suitable habitats at both local and drainage basin scales.
Cortical Networks Involved in Memory for Temporal Order

We examined the neurobiological basis of temporal resetting, an aspect of temporal order memory, using a version of the delayed-match-to-multiple-sample task. While in an fMRI scanner, participants evaluated whether an item was novel or whether it had appeared before or after a reset event that signified the start of a new block of trials. Participants responded “old” to items that were repeated within the current block and “new” to both novel items and items that had last appeared before the reset event (pseudonew items). Medial-temporal, prefrontal, and occipital regions responded to absolute novelty of the stimulus—they differentiated between novel items and previously seen items, but not between old and pseudonew items. Activation for pseudonew items in the frontopolar and parietal regions, in contrast, was intermediate between old and new items. The posterior cingulate cortex extending to precuneus was the only region that showed complete temporal resetting, and its activation reflected whether an item was new or old according to the task instructions regardless of its familiarity. There was also a significant Condition (old/pseudonew) × Familiarity (second/third presentations) interaction effect on behavioral and neural measures. For pseudonew items, greater familiarity decreased response accuracy, increased RTs, increased ACC activation, and increased functional connectivity between ACC and the left frontal pole. The reverse was observed for old items. On the basis of these results, we propose a theoretical framework in which temporal resetting relies on an episodic retrieval network that is modulated by cognitive control and conflict resolution.
An Investigation of Social Factors Affecting on Personnel Job Satisfaction of Remedial Service Insurance Department

Because of the paramount importance of job satisfaction and due to its main consequences such as reduction of work absence and resignation, personnel promotion and society’s health, and more importantly, its role in achievement of organization goals, this study aimed at investigating the effects of six social factors including personnel’s belief, salary and benefits, participation in organizational decision-making, sense of job security, interaction with colleagues and meeting the basic needs of personnel on job satisfaction. The statistical population of this study was the personnel of Remedial Service Insurance Department in Sari and the questionnaire was distributed among them. The results showed that there is a significant and positive correlation among all these factors and they have meaningful effects on personnel job satisfaction based on multiple regression analysis. Furthermore, findings revealed that personnel’s belief about their job has the most effects on job satisfaction.
Nephrotoxicity

&NA; Evidence in patients receiving cisplatin therapy BACKGROUND: Cisplatin has been used as a chemotherapeutic agent to treat many different cancers. A well‐known side effect of cisplatin is nephrotoxicity, which is the primary dose‐limiting toxicity. Hydration in conjunction with appropriate diuresis can decrease the incidence of nephrotoxicity. OBJECTIVES: This article aims to identify best practices in supportive therapy for patients receiving cisplatin therapy. METHODS: A team was assembled to review research‐based evidence and summarize recommendations to address appropriate hydration regimens and forced diuresis for patients receiving cisplatin chemotherapy. FINDINGS: After a systematic search of the literature, only one pediatric study was found. The remaining 22 research‐based studies of adults were synthesized and critically appraised. Hydration is necessary to prevent nephrotoxicity with cisplatin administration. In addition, the administration of magnesium and mannitol may assist in maintaining renal function and reducing nephrotoxicity in adults receiving cisplatin. Additional research is needed to evaluate outcomes of these interventions in the pediatric population.
Analysis of Transcriptional Responses of the Inflorescence Meristems in Jatropha curcas Following Gibberellin Treatment

Jatropha curcas L. seeds an oilseed plant with great potential for biodiesel production. However, low seed yield, which was limited by its lower female flowers, was a major drawback for its utilization. Our previous study found that the flower number and female-to-male ratio were increased by gibberellin treatment. Here, we compared the transcriptomic profiles of inflorescence meristem at different time points after gibberellic acid A3 (GA3) treatment. The present study showed that 951 differentially expressed genes were obtained in response to gibberellin treatment, compared with control samples. The 6-h time point was an important phase in the response to exogenous gibberellin. Furthermore, the plant endogenous gibberellin, auxin, ethylene, abscisic acid, and brassinolide-signaling transduction pathways were repressed, whereas the genes associated with cytokinin and jasmonic acid signaling were upregulated for 24-h time point following GA3 treatment. In addition, the floral meristem determinacy genes (JcLFY, JcSOC1) and floral organ identity genes (JcAP3, JcPI, JcSEP1-3) were significantly upregulated, but their negative regulator (JcSVP) was downregulated after GA3 treatment. Moreover, the effects of phytohormone, which was induced by exogenous plant growth regulator, mainly acted on the female floral differentiation process. To the best of our knowledge, this data is the first comprehensive analysis of the underlying transcriptional response mechanism of floral differentiation following GA3 treatment in J. curcas, which helps in engineering high-yielding varieties of Jatropha.
The brain of the tree pangolin (Manis tricuspis). I. General appearance of the central nervous system

Here, we describe the superficial appearance of the brain of the rarely studied tree pangolin. Phylogenetic analyses have placed the pangolins, order Pholidota, as a sister group to the order Carnivora. The majority of features visible on the surface of the tree pangolin brain, and its overall appearance can be described as typically mammalian. The pattern of sulci and gyri, while simple, appears very similar to that observed in carnivores. Two derived features of the Pholidota were observed, the first being the rostral decussation of the pyramidal tract, which instead of occurring at the spinomedullary junction, decussates at the level of the caudal pole of the facial nerve nucleus in the rostral medulla oblongata. This appears to be related to the need for voluntary control of the tongue, with a potentially enlarged corticobulbar tract ending in the hypoglossal nucleus. The second derived feature is the very short spinal cord, which terminates midway along the thoracic vertebrae before giving rise to a long and extensive cauda equina. This foreshortened spinal cord appears to be related to anisotropic growth of the somatic and neural elements following early development of the central nervous system. The olfactory system appears to be generally enlarged and is likely the predominant sense used in foraging. Vision and hearing do not appear specialized based on the relative size of the superior and inferior colliculi, but potential somatic specializations indicate that the somatosensory system is heavily relied upon for food consumption and prehensile tail usage.
Encapsulated source contact dose estimates incorporating secondary electron emission

Secondary electron emission generated at the surface of thin material from interaction with gamma rays form a significant component of the surface dose. The intensity of this emission is known to vary with material composition and incident radiation energies. The goal of this research effort is to estimate the emission strength from radioactive sources utilized in the early history of cancer Brachytherapy, and develop dose conversion factors from that data. Data was obtained by utilizing a comparative stochastic analysis, conducted with the Monte Carlo radiation transport code MCNPX. Emission intensities were measured at the surface of source encapsulation and at increasing distances in tissue equivalent material. It is shown that the results obtained correlate to the historical trends, however the electron component of the simulated emission is of greater by several orders of magnitude than that previously estimated. The dose conversion factors found from simulation will assign a higher absorbed dose than those currently published. The corollary is that the current published values are under attributing dose for a given radiation injury, which hinders effective treatment.
Real-Time Collection of Reliable and Representative Tweets Datasets Related to News Events

This paper is part of a wider work studying the co-inﬂuences of Twitter and the production of information by traditional media. A strong prerequisite of this study is to collect, with the limitations of the Twitter API, tweets linked to media events that are representative of the real Twitter activity. This paper describes two proposed approaches to handle this important task. The ﬁrst one, inspired by information retrieval, puts the focus on query formulation. It consists on bridging the vocabulary gap between traditional news articles and tweets, by iteratively modifying the queries sent to the Twitter API depending on the tweets retrieved by previous queries. The second approach consists in streaming a representative sample of all emitted tweets and dynamically clustering them in events. We also discuss approaches to evaluate the collected datasets under the point of view of their representativity of the real activity on Twitter.
Plasma debinding and sintering of metal injection moulded 17-4PH stainless steel

In this work, 17-4PH stainless steel parts processed in a Plasma Assisted Debinding and Sintering (PADS) furnace were characterised in terms of microstructure, final density, microhardness, carbon content and tensile behaviour. To determine whether these properties were satisfactory, the same characterisation procedure was conducted on the parts processed by conventional batch furnaces that are normally employed in Metal Injection Moulding industrial plants. The properties were in good agreement, and only slight differences like an extremely low carbon content (0.003% w/o) were observed. It has been seen that not only economical advances but also intricate materials with suitable responses may be obtained using PADS.