Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of previous grazing treatment and consumption of locoweed on liver mineral concentrations in beef steers.

Twelve Hereford steers (average BW = 231 kg) that had previously grazed native rangeland (Range) or irrigated winter wheat pasture (Wheat) were allowed to graze locoweed-infested rangeland from April 1 to June 9, 1994 (six steers/previous grazing treatment). Relative consumption level of locoweed and other forage classes was measured as observed bites per steer. Liver biopsy and whole blood samples were obtained from each steer before and after grazing. Liver samples were analyzed for several minerals by inductively coupled plasma-atomic emission spectroscopy, and whole blood samples were analyzed for Se. Liver concentrations of Ba (P < .001), Cd (P < .001), Ca (P < .01), Cr (P < .01), Ni (P < .001), Na (P < .01), and V (P < .001) were greater and concentrations of Mn (P < .09), P (P < .01), and K (P < .07) were less in Wheat than in Range steers. Liver concentrations of Fe, Mg, S, and Zn and whole blood Se concentrations did not differ (P > .10) between the two groups. Liver concentrations of Cr (P < .04) and Mn (P < .001) were less, and Fe concentrations were greater (P < .01), in samples taken after grazing than in samples taken before grazing of locoweed-infested range. Whole blood Se concentrations decreased (P < .01) from the beginning to the end of the grazing period, but this effect was not related (P > .15) to locoweed consumption. Changes in liver concentrations of minerals were compared relative to consumption levels of all forage classes in the locoweed-infested range. Liver concentrations of Cu decreased (r2 = .45; P < .02) as the percentage of bites consumed as locoweed increased, but concentrations after grazing locoweed-infested range were still within normal ranges. Changes in liver concentrations of other minerals were not related (P > .15) to consumption of locoweed. These data indicate that previous grazing history can have significant effects on liver mineral stores and that, under our conditions, consumption of locoweed by grazing beef steers altered liver Cu concentrations. Toxic effects of locoweed consumption would likely occur before Cu deficiency would be induced by grazing locoweed-infested range; hence, supplementation of Cu would seem unlikely to alter the course of locoweed toxicosis.
Stackelberg network pricing is hard to approximate

In the Stackelberg network pricing problem, one has to assign tariffs to a certain subset of the arcs of a given transportation network. The aim is to maximize the amount paid by the user of the network, knowing that the user will take a shortest st‐path once the tariffs are fixed. (Roch et al., Networks, 46 (2005), 57–67) proved that this problem is NP‐hard, and gave an O(log m)‐approximation algorithm, where m denote the number of arcs to be priced. In this note, we show that the problem is also APX‐hard. © 2010 Wiley Periodicals, Inc. NETWORKS, Vol. 57(2), 117–120 2011
Efficient Storage of XML Data

We introduce NATIX, an efficient, native repository for storing, retrieving and managing tree-structured large objects, preferably XML documents. In contrast to traditionallarge object (LOB) managers, we do not split at arbitrary byte positions but take the semantics of the underlying tree structure of XML documents into account. Our parameterizable split algorithm dynamically maintains physical records of size smaller than a page which contain sets of connected tree nodes. This not only improves efficiency by clustering subtrees but also facilitates their compact representation. Existing approaches to store XML documents either use flat files or map every single tree node onto a separate physical record. The increased flexibility of our approach results in higher efficiency. Performance measurements validate this claim.
Overexpression of myogenin in muscles of transgenic mice: interaction with Id-1, negative crossregulation of myogenic factors, and induction of extrasynaptic acetylcholine receptor expression

To investigate the role of myogenin in regulating acetylcholine receptor expression in adult muscle, this muscle-specific basic helix-loop-helix transcription factor was overexpressed in transgenic mice by using regulatory elements conferring strong expression confined to differentiated postmitotic muscle fibers. Many of the transgenic mice died during the first postnatal week, but those that survived into adulthood displayed normal muscle histology, gross morphology, and motor behavior. The mRNA levels of all five acetylcholine receptor subunits (alpha, beta, gamma, delta, and epsilon) were, however, elevated. Also, the level of receptor protein was increased and high levels of receptors were present throughout the extrasynaptic surface membrane of the muscle fibers. Thus, elevated levels of myogenin are apparently sufficient to induce acetylcholine supersensitivity in normally innervated muscle of adult mice. The high neonatal mortality rate of the mice overexpressing myogenin hindered the propagation of a stable line. In an attempt to increase survival, myogenin overexpressers were mated with a line of transgenic mice overexpressing Id-1, a negative regulator that interacts with the basic helix-loop-helix family of transcription factors. The Id-1 transgene apparently worked as a second site suppressor and abolished the high rate of neonatal mortality. This effect indicates that Id-1 and myogenin interact directly or indirectly in these animals. Further study indicated that myogenin overexpression had no effect on the level of endogenous myogenin mRNA, while the levels of myoD and MRF4 mRNAs were reduced. Overexpression of the negative regulator Id-1 increased the mRNA levels of all the myogenic factors. These findings are consistent with a hypothesis suggesting that myogenic factors are influenced by mechanisms that maintain cellular homeostasis.
Quality of life in long‐term survivors after liver transplantation: impact of recurrent viral hepatitis C virus hepatitis 1

Post liver transplant recurrence of infection with hepatitis C virus (HCV) occurs in approximately 50% of patients transplanted because of HCV‐related liver disease. The aim of this study was to assess long‐term quality of life, psychologic distress, and coping in patients with recurrent HCV after liver transplantation in comparison to patients transplanted for other etiologies of underlying liver disease. All liver transplant recipients transplanted at a University affiliated Veterans Affairs Medical Center who had greater than 6 months follow‐up were sent a questionnaire investigating quality of life (assessed by Medical Outcomes study health survey SF‐36), depression (assessed by Beck Depression Inventory), total mood disturbance (assessed by Profile of Mood States scale), coping (assessed by Billing and Moos Inventory of coping with illnesses), and employment status. Lower Beck Depression Inventory score (p=0.001), lower mood disturbance score (p=0.0001), overall satisfaction with present work (p=0.0001), and lesser use of avoidant coping (p=0.06) were predictors of better quality of life in long‐term survivors of liver transplantation. At a mean follow‐up of 4 yr after liver transplantation, patients with histopathologically diagnosed recurrent viral HCV hepatitis had significantly lower global quality of life score (mean score of 76.4 versus 86.2, p=0.011) and physical functioning score (mean score 20 versus 25, p=0.015), as compared to all other patients. In summary, quality of life and physical functioning were significantly impaired in liver transplant recipients with histopathologically diagnosed recurrent HCV hepatitis, as compared to those whose HCV hepatitis had not recurred or those transplanted for other reasons.
Development and validation of a measure of pediatric oral health-related quality of life: the POQL.

OBJECTIVE To develop a brief measure of oral health-related quality of life (OHQL) in children and demonstrate its reliability and validity in a diverse population. METHODS We administered the initial 20-item Pediatric Oral Health-Related Quality of Life (POQL) to children (Child Self-Report) and parents (Parent Report on Child) from diverse populations in both school-based and clinic-based settings. Clinical oral health status was measured on a subset of children. We used factor analysis to determine the underlying scales and then reduced the measure to 10 items based on several considerations. Multitrait analysis on the resulting 10-item POQL was used to reaffirm the discrimination of scales and assess the measure's internal consistency and interscale correlations. We established discriminant and convergent validity with clinical status, perceived oral health and responses on the PedsQL, and determined sensitivity to change with children undergoing ECC surgical repair. RESULTS Factor analysis returned a four-scale solution for the initial items--Physical Functioning, Role Functioning, Social Functioning, and Emotional Functioning. The reduced items represented the same four scales--two each on Physical and Role and three each on Social and Emotional. Good reliability and validity were shown for the POQL as a whole and for each of the scales. CONCLUSIONS The POQL is a valid and reliable measure of OHQL for use in preschool and school-aged children, with high utility for both clinical assessments and large-scale population studies.
IR-drop based electromigration assessment: Parametric failure chip-scale analysis

This paper presents a novel approach and techniques for electromigration (EM) assessment in power delivery networks. An increase in the voltage drop above the threshold level, caused by EM-induced increase in resistances of the individual interconnect segments, is considered as a failure criterion. This criterion replaces a currently employed conservative weakest segment criterion, which does not account an essential redundancy for current propagation existing in the power-ground (p/g) networks. EM-induced increase in the resistance of the individual grid segments is described in the approximation of the physics-based formalism for void nucleation and growth. A developed technique for calculating the hydrostatic stress distribution inside a multi branch interconnect tree allows to avoid over optimistic prediction of the time to failure made with the Blech-Black analysis of individual branches of interconnect segment. Experimental results obtained on the IBM benchmark circuit validate the proposed methods.
Rapid determination of human cytomegalovirus susceptibility to ganciclovir directly from clinical specimen primocultures

We were able to rapidly determine the susceptibility of human cytomegalovirus to ganciclovir using a late antigen synthesis reduction assay directly on primocultures of clinical specimens. This test was compared with a conventional susceptibility assay which was performed with cell-free virus obtained after cytomegalovirus isolation and in vitro passages. Both tests produced similar results. The rapid test, unlike conventional assays, is able to provide a result within 5 days after receipt of the specimen and could thus play a direct role in the therapeutic decision.
Existence Detection of Objects in Images for Robot Vision Using Saliency Histogram Features

In robotics and computer vision, saliency maps are frequently used to identify regions that contain potential objects of interest and to restrict object detection to those regions only. However, common saliency approaches do not provide information as to whether there really is an interesting object triggering saliency and therefore tend to highlight needless background as potential regions of interest. This paper addresses the problem by exploiting histogram features extracted from saliency maps to predict the existence of interesting objects in images and to quickly prune uninteresting images. To validate our approach, we constructed a database that consists of 1000 background and object images captured in the working environment of our robot. Experimental results demonstrate that our approach achieves good detection performance and outperforms an existing existence detection approach [1].
[Study on the function of keratinocyte growth factor on apoptosis of oral mucosal epithelial cells].

OBJECTIVE To study the function of keratinocyte growth factor (KGF) on apoptosis of oral mucosal epithelial cells and to provide a basis for further investigation of the role of KGF in the occurrence and development of oral mucosal diseases. METHODS Different concentrations of KGF (control group, 0 ng x mL(-1); experiment 1 group, 5 ng x mL(-1); experimental 2 group, 25 ng x mL(-1); experiment 3 group, 50 ng x mL(-1)) were added in oral mucosa epithelial cells cultured in vitro. After training for 12, 24, and 48 h, cell morphology was observed under an inverted microscope. Apoptosis was detected by using a flow cytometry instrument, and mRNA expression of apoptosis-related genes Bcl-2 and Bax was detected by using Real-Time fluorescent quantitative detection. RESULTS Cell adherence of the experimental group was more obvious than that of the control group, and the cell nucleolus of the experiment 3 group was obviously cultured at 48 h. After culturing for 48 h, the apoptosis rate and Bcl-2 and Bax mRNA expression among the four groups were statistically significant. The increase of KGF concentration, apoptosis rate, and Bax mRNA expression gradually reduced, whereas Bcl-2 mRNA expression increased (P < 0.05). CONCLUSION KGF may inhibit epithelial cell apoptosis through upregulation of Bcl-2 mRNA and downregulation of Bax mRNA.
Synergistic Effects of Cellulosomal Xylanase and Cellulases from Clostridium cellulovorans on Plant Cell Wall Degradation

ABSTRACT Plant cell walls are comprised of cellulose and hemicellulose and other polymers that are intertwined, and this complex structure presents a barrier to degradation by pure cellulases or hemicellulases. In this study, we determined the synergistic effects on corn cell wall degradation by the action of cellulosomal xylanase XynA and cellulosomal cellulases from Clostridium cellulovorans. XynA minicellulosomes and cellulase minicellulosomes were found to degrade corn cell walls synergistically but not purified substrates such as xylan and crystalline cellulose. The mixture of XynA and cellulases at a molar ratio of 1:2 showed the highest synergistic effect of 1.6 on corn cell wall degradation. The amounts both of xylooligosaccharides and cellooligosaccharides liberated from corn cell walls were increased by the synergistic action of XynA and cellulases. Although synergistic effects on corn cell wall degradation were found in simultaneous reactions with XynA and cellulases, no synergistic effects were observed in sequential reactions. The possible mechanism of synergism between XynA and cellulases is discussed.
Phages of non-dairy lactococci: isolation and characterization of ΦL47, a phage infecting the grass isolate Lactococcus lactis ssp. cremoris DPC6860

Lactococci isolated from non-dairy sources have been found to possess enhanced metabolic activity when compared to dairy strains. These capabilities may be harnessed through the use of these strains as starter or adjunct cultures to produce more diverse flavor profiles in cheese and other dairy products. To understand the interactions between these organisms and the phages that infect them, a number of phages were isolated against lactococcal strains of non-dairy origin. One such phage, ΦL47, was isolated from a sewage sample using the grass isolate L. lactis ssp. cremoris DPC6860 as a host. Visualization of phage virions by transmission electron microscopy established that this phage belongs to the family Siphoviridae and possesses a long tail fiber, previously unseen in dairy lactococcal phages. Determination of the lytic spectrum revealed a broader than expected host range, with ΦL47 capable of infecting 4 industrial dairy strains, including ML8, HP and 310, and 3 additional non-dairy isolates. Whole genome sequencing of ΦL47 revealed a dsDNA genome of 128, 546 bp, making it the largest sequenced lactococcal phage to date. In total, 190 open reading frames (ORFs) were identified, and comparative analysis revealed that the predicted products of 117 of these ORFs shared greater than 50% amino acid identity with those of L. lactis phage Φ949, a phage isolated from cheese whey. Despite their different ecological niches, the genomic content and organization of ΦL47 and Φ949 are quite similar, with both containing 4 gene clusters oriented in different transcriptional directions. Other features that distinguish ΦL47 from Φ949 and other lactococcal phages, in addition to the presence of the tail fiber and the genome length, include a low GC content (32.5%) and a high number of predicted tRNA genes (8). Comparative genome analysis supports the conclusion that ΦL47 is a new member of the 949 lactococcal phage group which currently includes the dairy Φ949.
Physio-biochemical and morphological characters of halophyte legume shrub, Acacia ampliceps seedlings in response to salt stress under greenhouse

Acacia ampliceps (salt wattle), a leguminous shrub, has been introduced in salt-affected areas in the northeast of Thailand for the remediation of saline soils. However, the defense mechanisms underlying salt tolerance A. ampliceps are unknown. We investigated various physio-biochemical and morphological attributes of A. ampliceps in response to varying levels of salt treatment (200–600 mM NaCl). Seedlings of A. ampliceps (25 ± 2 cm in plant height) raised from seeds were treated with 200 mM (mild stress), 400 and 600 mM (extreme stress) of salt treatment (NaCl) under greenhouse conditions. Na+ and Ca2+ contents in the leaf tissues increased significantly under salt treatment, whereas K+ content declined in salt-stressed plants. Free proline and soluble sugar contents in plants grown under extreme salt stress (600 mM NaCl) for 9 days significantly increased by 28.7 (53.33 μmol g–1 FW) and 3.2 (42.11 mg g–1 DW) folds, respectively over the control, thereby playing a major role as osmotic adjustment. Na+ enrichment in the phyllode tissues of salt-stressed seedlings positively related to total chlorophyll (TC) degradation (R2 = 0.72). Photosynthetic pigments and chlorophyll fluorescence in salt-stressed plants increased under mild salt stress (200 mM NaCl). However, these declined under high levels of salinity (400–600 mM NaCl), consequently resulting in a reduced net photosynthetic rate (R2 = 0.81) and plant dry weight (R2 = 0.91). The study concludes that A. ampliceps has an osmotic adjustment and Na+ compartmentation as effective salt defense mechanisms, and thus it could be an excellent species to grow in salt-affected soils.
Parity-check density versus performance of binary linear block codes over memoryless symmetric channels

We derive lower bounds on the density of parity-check matrices of binary linear codes which are used over memoryless binary-input output-symmetric (MBIOS) channels. The bounds are expressed in terms of the gap between the rate of these codes for which reliable communications is achievable and the channel capacity; they are valid for every sequence of binary linear block codes if there exists a decoding algorithm under which the average bit-error probability vanishes. For every MBIOS channel, we construct a sequence of ensembles of regular low-density parity-check (LDPC) codes, so that an upper bound on the asymptotic density of their parity-check matrices scales similarly to the lower bound. The tightness of the lower bound is demonstrated for the binary erasure channel by analyzing a sequence of ensembles of right-regular LDPC codes which was introduced by Shokrollahi, and which is known to achieve the capacity of this channel. Under iterative message-passing decoding, we show that this sequence of ensembles is asymptotically optimal (in a sense to be defined in this paper), strengthening a result of Shokrollahi. Finally, we derive lower bounds on the bit-error probability and on the gap to capacity for binary linear block codes which are represented by bipartite graphs, and study their performance limitations over MBIOS channels. The latter bounds provide a quantitative measure for the number of cycles of bipartite graphs which represent good error-correction codes.
Tactile Political Maps: Two Experimental Designs

Examines the design of tactile political maps by constructing two experimental maps having either a broad raised line or a broad incised line. Performance on these two maps was compared with performance on a thin raised line map (control), which is typically found in braille books. The subjects were 72 braille readers in grades 4-12. Performance on the broad raised line map was superior to performance on the control map. Performance on the broad incised line map did not differ from performance on the control map.
Diagnosis and Management of Bacterial Meningitis in the Paediatric Population: A Review

Paediatric bacterial meningitis is a neurological emergency which, despite advances in medical management, still has a significant morbidity and mortality. Over recent decades new vaccines have led to a change in epidemiology of the disease; however, it remains a condition that requires a high index of suspicion, prompt diagnosis, and early management in the emergency department. New laboratory techniques and clinical tools are aiding the diagnosis of bacterial meningitis, yet some controversies still exist in its management. This paper outlines the changing epidemiology of the disease, current diagnostic techniques as well as controversies and advances in the management of bacterial meningitis in the paediatric population.
Are ‘Good’ Citizens ‘Good’ Participants? Testing Citizenship Norms and Political Participation across 25 Nations

Whereas research on political participation typically investigates a variety of socio-economic and attitudinal characteristics, this cross-national study focuses on the relevance of norms when explaining political participation. We examine respondents' normative beliefs about the importance of various measures of ‘good citizenship’, and their relationship to three modes of political engagement (activism, party membership and voting). We find assigning higher importance to paying taxes/obeying the law is negatively linked to all forms of participation, whereas the opposite is true for norms about the importance of voting and being active in associations. Greater emphasis on norms about understanding others and shopping politically is positively associated with political activism but not with more institutional forms of participation. The relationship between norms and participation differs somewhat across nations, with the most differences between Eastern European respondents and those from Western European and Western non-European respondents. In line with theories on democratic learning, we find that the relationship between citizenship norms and participation is often weakest among Eastern Europeans. Conclusions about the subjective and variable nature of democratic citizenship are discussed.