Miracle-dz/UniFAR-FTUs huggingface dataset:
5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme

5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression. Deregulation of TET enzymes causes developmental defects and is associated with pathological conditions such as cancer. Little information thus far is available on the regulation of TET activity by post-translational modifications. Here we show that TET1 protein is able to interact with PARP-1/ARTD1 enzyme and is target of both noncovalent and covalent PARylation. In particular, we have demonstrated that the noncovalent binding of ADP-ribose polymers with TET1 catalytic domain decreases TET1 hydroxylase activity while the covalent PARylation stimulates TET1 enzyme. In addition, TET1 activates PARP-1/ARTD1 independently of DNA breaks. Collectively, our results highlight a complex interplay between PARylation and TET1 which may be helpful in coordinating the multiple biological roles played by 5-hydroxymethylcytosine and TET proteins.
Job Seekers&Apos; Perceptions and Employment Prospects: Heterogeneity, Duration Dependence and Bias

This paper analyses job seekers' perceptions and their relationship to unemployment outcomes to study heterogeneity and duration dependence in both perceived and actual job finding. Using longitudinal data from two comprehensive surveys, we document that elicited beliefs are (1) strongly predictive of actual job finding, (2) subject to an optimistic bias that is larger for the long-term unemployed, and (3) not revised downward when job seekers remain unemployed. We exploit the joint observation of beliefs and ex-post realizations, to disentangle heterogeneity and duration dependence in true job finding rates. To this purpose, we estimate non-parametric bounds as well as a reduced-form statistical framework that allows for elicitation errors and systematic biases in beliefs. We find a substantial amount of heterogeneity in true job finding rates, accounting for most of the observed decline in job finding rates over the spell of unemployment. We also find that job seekers' beliefs systematically under-react to these differences in job finding rates. We show theoretically and quantify in a calibrated model of job search how these biased beliefs contribute to the slow exit out of unemployment and can explain more than 10 percent of the incidence of long-term unemployment.
Long‐lasting allergic patch test reactions: a study of patients with positive standard patch tests

The purpose of this study was to determine the duration of patch test reactions and the frequency of long‐lasting allergic patch test reactions (LLAPTR), and to identify the possible factors related to the development of the LLAPTR. For this purpose, a group of 263 patients positive to 1 or more allergens in the GIRDCA standard series was recruited. Readings were made for each patient 2 and 3 days after patch test application and continued every 2nd and 3rd day until the disappearance of all palpable erythema. The % of LLAPTR out of the total of reactions was high: 17.9%. Kathon CG was the hapten that caused LLAPTR most frequently, with 16 cases, a frequency of 76.1%, and a mean duration of the patch test reactions of 25.4 days. Risk factors investigated were age, sex, atopy, intensity of the patch test reaction and sensitivity to some allergens with the greatest number of positive patch tests. The relative importance of each risk factor was calculated by multivariate stepwise logistic regression analysis. It was found that a Kathon CG sensitivity was the most important risk factor for LLAPTR. 2nd was atopy, followed by strong patch test reaction. Rejected risk factors were sex, age and sensitivity to nickel sulfate, potassium dichromate, Disperse Blue 124, fragrance mix and p‐phenylenediamine.
Temporal Properties of Liquid Crystal Displays: Implications for Vision Science Experiments

Liquid crystal displays (LCD) are currently replacing the previously dominant cathode ray tubes (CRT) in most vision science applications. While the properties of the CRT technology are widely known among vision scientists, the photometric and temporal properties of LCDs are unfamiliar to many practitioners. We provide the essential theory, present measurements to assess the temporal properties of different LCD panel types, and identify the main determinants of the photometric output. Our measurements demonstrate that the specifications of the manufacturers are insufficient for proper display selection and control for most purposes. Furthermore, we show how several novel display technologies developed to improve fast transitions or the appearance of moving objects may be accompanied by side–effects in some areas of vision research. Finally, we unveil a number of surprising technical deficiencies. The use of LCDs may cause problems in several areas in vision science. Aside from the well–known issue of motion blur, the main problems are the lack of reliable and precise onsets and offsets of displayed stimuli, several undesirable and uncontrolled components of the photometric output, and input lags which make LCDs problematic for real–time applications. As a result, LCDs require extensive individual measurements prior to applications in vision science.
The threshold for diagnosing impaired fasting glucose

The category of IFG was introduced in the late 1990s to denote a state of non-diabetic hyperglycaemia defined by a fasting plasma glucose (FPG) concentration between 6.1 and 6.9 mmol/l. In 2003 the American Diabetes Association recommended that this diagnostic threshold be lowered to 5.6 mmol/l. The justification for lowering the threshold has been questioned. This simple change in cut-off value creates a pandemic of IFG, with a twoto five-fold increase in the prevalence of IFG across the world. Such a change in threshold has far-reaching public health implications. The European Diabetes Epidemiology Group (EDEG) has reviewed the evidence for this lower cut-off point for the definition of IFG and concludes that the previous definition should not be altered. EDEG further recommends that the value of all categorical definitions of non-diabetic hyperglycaemia should be reconsidered. Abbreviations ADA: American Diabetes Association . CVD: cardiovascular disease . DECODE: diabetes epidemiology collaborative analysis of diagnostic criteria in Europe . DESIR: data from an epidemiological study on the insulin resistance syndrome . EDEG: European Diabetes Epidemiology Group . FPG: fasting plasma glucose . HR: hazard ratio . IFG: impaired fasting glucose . RR: relative risk
Can FAVAR improve Swedish inflation forecasting

The purpose of this thesis is to investigate whether factor augmented vectorautoregression (FAVAR) models estimated using principal component analysis are able to improve monthly inflation rate forecasts for Sweden. We produce 42 forecasts for the period January 2012 to June 2015 and evaluate the forecasts by their root mean square errors as well as their ability to correctly predict the sign of the inflation rate. The models forecasting performances are compared using the Diebold-Mariano test of equal predictive accuracy. Our results show that the investigated FAVAR models cannot significantly improve forecasts relative to a univariate model and that the FAVAR models perform worse with twelve lags than with only one lag.
Where Is the Inner Edge of an Accretion Disk around a Black Hole?

What is meant by the "inner edge" of an accretion disk around a black hole depends on the property that defines the edge. We discuss four such definitions, using data from recent high-resolution numerical simulations. These are (1) the "turbulence edge," where flux-freezing becomes more important than turbulence in determining the magnetic field structure; (2) the "stress edge," where plunging matter loses dynamical contact with the outer accretion flow; (3) the "reflection edge," the smallest radius capable of producing significant X-ray reflection features; and (4) the "radiation edge," the innermost place from which significant luminosity emerges. All these edges are dependent on the accretion rate and are nonaxisymmetric and time-variable. Although all are generally located in the vicinity of the marginally stable orbit, significant displacements can occur, and data interpretations placing the disk edge precisely at this point can be misleading. If observations are to be used successfully as diagnostics of accretion in strong gravity, the models used to interpret them must take careful account of these distinctions.
How do primary care physicians use long-term acid suppressant drugs? A population-based analysis of Dutch general practices.

OBJECTIVES A considerable proportion of the medication budget of Dutch general practitioners is spent on prescribed long-term acid suppressant drugs. We investigated the magnitude of long-term prescription of acid suppressant drugs in general practice and the frequency and means of confirming the primary working diagnosis. STUDY DESIGN We used a retrospective descriptive study of 24 general practices in the Amsterdam region. POPULATION We identified those receiving long-term acid suppressant therapy (12 or more weeks/year) from a total of 46,813 patients by extracting data from pharmacy databases. OUTCOMES MEASURED We measured the amount and duration of prescriptions for each medication, indications for prescription, and investigations performed by general practitioners. RESULTS Of the 46,813 patients, 922 (2%) received long-term acid suppressant therapy. The duration of prescription varied from 12 weeks in 8% of patients to > 52 weeks in 23% of patients (mean = 33 weeks). In 25% of patients, no investigations were performed; 75% of patients underwent endoscopy or ingested a barium meal. The predominant diagnoses in investigated patients were ulcer disease (39%), gastroesophageal reflux disease (49%), and functional dyspepsia (gastritis, normal aspect; 18%). Helicobacter pylori status was available in 29% of patients with ulcer disease. Eradication therapy was reported in 44% of these patients. CONCLUSIONS Among patients of physicians in general practice in the Amsterdam region, 2% used long-term acid suppressants. Patients with ulcer disease may stop taking acid suppressants after apparent successful H pylori eradication. Tapering strategies must be developed for patients with mild reflux disease or functional dyspepsia.
Unemployment and Real Exchange Rate Dynamics in Latin American Economies

Edwards and Savastano's (2000) survey identify two important limitations of the real exchange rate (RER) literature: the lack of explicit derivation of flow and stock equilibrium variables as determinants of the equilibrium RER and the failure to allow for unemployment. This paper develops a general equilibrium model that includes both elements, as well as other traditional determinants of the RER such as productivity, terms of trade and government policies. The model is tested against the experience of ten Latin American economies in the 1970-2004 period. From an econometric point of view the model is consistent with the evidence, providing an estimate of the RER misalignment. When evaluating the contribution of labor market distortions to changes in the equilibrium RER, they appear to be less significant than changes in productivity or government policies.
Altering the redox state of skeletal muscle by glutathione depletion increases the exercise‐activation of PGC‐1α

We investigated the relationship between markers of mitochondrial biogenesis, cell signaling, and antioxidant enzymes by depleting skeletal muscle glutathione with diethyl maleate (DEM) which resulted in a demonstrable increase in oxidative stress during exercise. Animals were divided into six groups: (1) sedentary control rats; (2) sedentary rats + DEM; (3) exercise control rats euthanized immediately after exercise; (4) exercise rats + DEM; (5) exercise control rats euthanized 4 h after exercise; and (6) exercise rats + DEM euthanized 4 h after exercise. Exercising animals ran on the treadmill at a 10% gradient at 20 m/min for the first 30 min. The speed was then increased every 10 min by 1.6 m/min until exhaustion. There was a reduction in total glutathione in the skeletal muscle of DEM treated animals compared to the control animals (P < 0.05). Within the control group, total glutathione was higher in the sedentary group compared to after exercise (P < 0.05). DEM treatment also significantly increased oxidative stress, as measured by increased plasma F2–isoprostanes (P < 0.05). Exercising animals given DEM showed a significantly greater increase in peroxisome proliferator activated receptor γ coactivator‐1α (PGC–1α) mRNA compared to the control animals that were exercised (P < 0.05). This study provides novel evidence that by lowering the endogenous antioxidant glutathione in skeletal muscle and inducing oxidative stress through exercise, PGC‐1α gene expression was augmented. These findings further highlight the important role of exercise induced oxidative stress in the regulation of mitochondrial biogenesis.
Spatial and temporal expression of the response regulators ARR 22 and ARR 24 in Arabidopsis thaliana

ARR22 (At3g04280) is a novel Type A response regulator whose function in Arabidopsis is unknown. RT-PCR analysis has shown that expression of the gene takes place in flowers and developing pods with the tissues accumulating different proportions of splice variants. Spatial analysis of expression, using ARR22:: GUS plants as a marker, has revealed that the reporter protein accumulates specifically at the junction between the funiculus and the chalazal tissue. Expression can be up-regulated at this location by wounding the developing seed. A detailed analysis has failed to detect ARR22 expression at any other sites and, to support this assertion, the only evidence for tissue ablation in ARR22::Barnase plants is during seed development, with the consequence that embryo growth is attenuated. Ectopic expression of ARR22, driven by either the CaMV 35S or the pea plastocyanin (PPC) promoters, resulted in the generation of plants exhibiting extremely stunted root and shoot growth. No viable progeny could be isolated from the PPC::ARR22 transgenic lines. An RT-PCR analysis of a recently annotated gene (ARR24– At5g26594), that exhibits 66% amino acid similarity to ARR22, has shown that expression is also predominantly in floral and silique tissues. Examination of ARR24::GUS plants has revealed that the activity of the promoter is primarily restricted to pollen grains indicating that this gene is unlikely to display an overlapping function with ARR22. Analyses of individual KO lines of either ARR22 or ARR24 have failed to identify a mutant phenotype under the growth conditions employed and the double knockout ARR22/ ARR24 line is also indistinguishable from wild-type plants. These results are discussed in the light of the proposed role of response regulators in plant growth
Psychosocial Risks and Job Satisfaction in Argentinian Scholars: Exploring the Moderating Role of Work Engagement

The increasing psychosocial risks imposed on today’s scholars have turned their profession into a highly stressful career path. Drawing on evidence collected in a sample of 177 scholars from an Argentinian public university, this study explores the buffering role of work engagement in the relationship between perceived exposure to six work-related psychosocial risk factors, namely psychological demands, insufficient autonomy, lack of social support and leadership, insufficient esteem, double presence, and job insecurity, and job satisfaction. Hierarchical regression analyses resulted in three out of six possible interaction effects, revealing that work engagement indeed moderates the effects of psychological demands, lack of social support and leadership, and insufficient esteem on scholars’ job satisfaction. We discuss the findings in relation to directions proposed for future research.
Dynamic Approach for Diversification Effectiveness Evaluation of Berezovsky Company Town

Article represents the dynamic approach for diversification effectiveness assessment of company town Berezovsky that modifies the structure of it economy towards the multisectoral one. The effectiveness concept is considered as comparison between stated goals and opportunities to reach them. The authors evolved an autoregressive model with distributed lags of the first order type to describe the dependence between the share of the core industry in dispatched goods on its previous value and on the share of investments in core industry. The core industry of Berezovsky company town is mining operations including fossil fuels extraction and extraction of other minerals. The autoregressive model allows forecasting the share of dispatched goods in mining operations. Making the conclusion on opportunities to achieve the diversification targets let authors evaluate the diversification effectiveness.
Epidemiological Studies of the Effect of Stroke on Incident Dementia: A Systematic Review

Background and Purpose— Stroke is implicated in the incidence of dementia, and the risk of poststroke dementia is well characterized, but the excess risk of dementia in those with stroke compared with those without stroke is not well known. Methods— We conducted a systematic review of the excess risk of incident dementia conferred by stroke. Studies of the risk of incident dementia in the population with stroke compared with the population without stroke were identified and compared. Results— Sixteen studies were identified with all but one conducted in a community setting. A history of stroke doubles the risk of incident dementia in the older population. This increase is not explained by demographic or cardiovascular risk factors or by prestroke cognitive decline. The excess risk of incident dementia diminishes with time after stroke and may be higher in those without an APOE &egr;4 allele. There is no excess risk of incident dementia in those aged >85 years with a history of stroke compared to those aged >85 years without stroke. Conclusions— The effect of stroke on dementia incidence in the population is not explained by common risk factors. At this time of population aging and increased stroke survival, more research is needed to determine to what extent efforts to reduce the incidence of stroke will affect the incidence of dementia.
Effect of testosterone and a nutritional supplement , alone and in combination , on hospital admissions in undernourished older men and women 1 – 3

Background: In older people, undernutrition is associated with increased hospitalization rates and mortality. Because weight loss in older people often reflects a disproportionate reduction of skeletal muscle, anabolic treatments may be beneficial. Objective: Our aim was to evaluate the hypothesis that testosterone treatment and a nutritional supplement have additive benefits. Design: Oral testosterone undecanoate (40 mg daily for women, 80 mg twice daily for men) and an oral nutritional supplement (475 kcal/d) were administered, alone or combined, for 1 y to 49 communitydwelling, undernourished people [Mini Nutritional Assessment score ,24 and low body weight (body mass index, in kg/m: ,22) or recent weight loss (.7.5% over 3 mo)] aged . 65 y (mean age: 77 y; 26 women and 23 men). Hospital admissions and other variables were assessed. Results: In subjects receiving combined testosterone and nutritional supplements (n 1⁄4 11), there were no hospital admissions, whereas there were 9 admissions (2 elective) in 13 subjects in the no-treatment group, 4 in the testosterone-treated group (n 1⁄4 12), and 5 in the supplement-treated group (n 1⁄4 13); P 1⁄4 0.06 with no-treatment compared with combined treatment. When compared with the notreatment group, the combined-treatment group had significantly fewer subjects admitted to hospital (0 compared with 5, P 1⁄4 0.03), fewer days in hospital (0 compared with 74, P 1⁄4 0.041), and a longer time to hospital admission (P 1⁄4 0.017). Conclusions: In undernourished older people, combined treatment with testosterone and nutritional supplementation reduced the number of people hospitalized and the duration of hospital admissions, which are important endpoints in this group. Larger, confirmatory studies are now needed. This trial was registered before commencement at clinical trials.gov as NCT00117000. Am J Clin Nutr 2009;89:880–9.
Production of Vermicompost from Temple Waste ( Nirmalya ) : A Case Study

Vermicomposting is the phenomenon of compost formation by earthworms. Earthworms play an important role in the cycling of plant nutrients, turnover the organic matter and maintain the soil structure. The temple wastes consist of vegetable material (mainly flowers, leaves, fruits, sugar, jaggery etc.), milk and milk products, grains and water most of which are biodegradable and contain elements required for growth of microorganisms and the temple wastes are released in the water bodies or dumped at the available places of land which creates severe environmental pollution and health hazards ,hence it was thought to attempt use temple waste for ecofriendly treatment methods like Biomethanation and vermicomposting. The effluent of biomethanation upon mixing with biodegradable organic solids serves as good raw material for vermicomposting. In the present studies vermicomposting, the effluent from biogas digester (biomethanation) run on Ganesh temple waste (Sangli, Maharashtra) was admixed with temple waste solids and cattle dung and after partial the decomposition for 30 days at 30 O c, it was used to fill up 2 kg capacity plastic tubs and subjected for optimization of parameters like moisture content, particle size, p H of material and temperature of vermicomposting using Eudrilus eugeniae earth worm species. It was found that 25 o C temperature, pH 8.0, 1-2mm particle size and 80% moisture content were optimum parameters of vermicomposting. It was further found that vermicompost obtained by above method was rich in percent carbon, Nitrogen, Phosphorus and Potassium content i.e. 28, 1.58, 0.33 and 0.28, respectively. The pot culture studies using five flowering plants (Gulab, Jaswand and Mogra varieties) of the test set (using prepared vermicompost as fertilizer) used in the studies showed good enhancement of growth in terms of height, flowering time as well as number of flowers produced as compared to control sets(without use of vermicompost as fertilizer). Thus, vermicomposting of temple waste is an excellent and ecofriendly method of temple waste management.
Data-driven soft sensor design with multiple-rate sampled data: A comparative study

Multi-rate systems are common in industrial processes where quality measurements have slower sampling rate than other process variables. Since inter-sample information is desirable for effective quality control, different approaches have been reported to estimate the quality between samples, including numerical interpolation, polynomial transformation, data lifting and weighted partial least squares (WPLS). Two modifications to the original data lifting approach are proposed in this paper: reformulating the extraction of a fast model as an optimization problem and ensuring the desired model properties through Tikhonov Regularization. A comparative investigation of the four approaches is performed in this paper. Their applicability, accuracy and robustness to process noise are evaluated on a single-input single output (SISO) system. The regularized data lifting and WPLS approaches are implemented to design quality soft sensors for cement kiln processes using data collected from a plant log system. Preliminary results reveal that the WPLS approach is able to provide accurate one-step-ahead prediction. The regularized data lifting technique predicts the product quality of cement kiln systems reasonably well, demonstrating the potential to be used for effective quality control.