Miracle-dz/UniFAR-FTUs huggingface dataset:
Nurse practitioner perceptions of barriers and facilitators in providing health care for deaf American Sign Language users: A qualitative socio‐ecological approach

BACKGROUND AND PURPOSE Nurse practitioners (NPs), as well as all healthcare clinicians, have a legal and ethical responsibility to provide health care for deaf American Sign Language (ASL) users equal to that of other patients, including effective communication, autonomy, and confidentiality. However, very little is known about the feasibility to provide equitable health care. The purpose of this study was to examine NP perceptions of barriers and facilitators in providing health care for deaf ASL users. DATA SOURCES Semistructured interviews in a qualitative design using a socio-ecological model (SEM). CONCLUSIONS Barriers were identified at all levels of the SEM. NPs preferred interpreters to facilitate the visit, but were unaware of their role in assuring effective communication is achieved. A professional sign language interpreter was considered a last resort when all other means of communication failed. Gesturing, note-writing, lip-reading, and use of a familial interpreter were all considered facilitators. IMPLICATIONS FOR PRACTICE Interventions are needed at all levels of the SEM. Resources are needed to provide awareness of deaf communication issues and legal requirements for caring for deaf signers for practicing and student NPs. Protocols need to be developed and present in all healthcare facilities for hiring interpreters as well as quick access to contact information for these interpreters.
Claudin expression is dysregulated in prostate adenocarcinomas but does not correlate with main clinicopathological parameters

Aims: Claudins, a large family of essential tight junction (TJ) proteins, are abnormally regulated in human carcinomas. The aim of this study was to determine the expression of claudins 1, 2, 3, 4, 5, 7, and 11 in prostate samples from Brazilian patients and correlate it with the clinicopathological features of prostate cancer. Methods: Using a tissue microarray (TMA) of specimens of prostate adenocarcinoma and benign prostatic hyperplasia (BPH) we analysed the expression of claudins 1, 2, 3, 4, 5, 7, and 11 by immunohistochemistry. Results: Claudin 4 was down-regulated and claudins 2, 3, and 5 were overexpressed in prostate adenocarcinomas compared with BPH samples. Expression of claudins 1 and 7 was similar in tumours and BPH samples. Claudin 11 was absent from all prostate samples. Overexpression of claudin 3 was associated with perineural invasion (p = 0.014) and tended to occur in advanced stages of the disease (p = 0.064). Increased expression of claudin 5 was marginally associated with perineural invasion (p = 0.060). Conclusions: Our results suggest that alterations in claudin expression occur in prostate cancer cells, although we have not found an association with the main clinicopathological parameters.
Exact Inference Techniques for the Analysis of Bayesian Attack Graphs

Attack graphs are a powerful tool for security risk assessment by analysing network vulnerabilities and the paths attackers can use to compromise network resources. The uncertainty about the attacker's behaviour makes Bayesian networks suitable to model attack graphs to perform static and dynamic analysis. Previous approaches have focused on the formalization of attack graphs into a Bayesian model rather than proposing mechanisms for their analysis. In this paper we propose to use efficient algorithms to make exact inference in Bayesian attack graphs, enabling the static and dynamic network risk assessments. To support the validity of our approach we have performed an extensive experimental evaluation on synthetic Bayesian attack graphs with different topologies, showing the computational advantages in terms of time and memory use of the proposed techniques when compared to existing approaches.
Under Consideration for Publication in Knowledge and Information Systems on Clustering Massive Text and Categorical Data Streams

In this paper, we will study the data stream clustering problem in the context of text and categorical data domains. While the clustering problem has been studied recently for numeric data streams, the problems of text and categorical data present different challenges because of the large and un-ordered nature of the corresponding attributes. Therefore, we will propose algorithms for text and categorical data stream clustering. We will propose a condensation based approach for stream clustering which summarizes the stream into a number of fine grained cluster droplets. These summarized droplets can be used in conjunction with a variety of user queries to construct the clusters for different input parameters. Thus, this provides an online analytical processing approach to stream clustering. We also study the problem of detecting noisy and outlier records in real time. We will test the approach for a number of real and synthetic data sets, and show the effectiveness of the method over the baseline OSKM algorithm for stream clustering.
Volume of metric balls in real Grassmann manifold with an application to frames

Volume estimates of metric balls in manifolds find diverse applications in various applied sciences including information theory and coding theory. In this paper, the focus is on the exact volume of metric balls in real Grassmann manifold, extending recent results of the complex case. Firstly, we formulate the exact volume as a multi-dimensional integral, which is then represented as an inverse Laplace transform of a Pfaffian. The Pfaffian structure arises as a result of the de-Bruijn formula for multi-dimensional integrals. Using the exact representation, examples of explicit volume formulas are given. As an application, we study the performance bound of the worst-case coherence of Grassmannian frames.
Postnatal depression and infant development.

published indicates that the grief experienced by couples after a spontaneous miscarriage is as intense as that after a perinatal death. ' In a study of 300 patients followed up one month after a miscarriage 96% reported experiencing a grief reaction and in 21% the grief had not yet resolved. ' In a more detailed study 44% of 27 women interviewed several months after a miscarriage showed clinical levels of psychological distress as measured by the general health questionnaire. ' In a study of 67 women one month after a miscarriage the prevalence of "psychiatric cases" as measured by the present state examination was 48%. ' In two of these studies no demographic or clinical features were identified that could predict which women were liable to experience a normal or prolonged grief reaction.4 In particular, the griefexperienced could not be related to the length of pregnancy. I'he only factor that seemed to alleviate the distress experienced was an opportunity to discuss the miscarriage with medical staff after the event. ' Trhus all couples who experience a miscarriage should have the opportunity to avail themselves of information and counselling and not just those in whom "exceptional distress [is] caused by a miscarriage. "' Offering couples what they need and want after a spontaneous miscarriage is sound clinical practice" and is not being "overzealous"' or pushing people "into magnifying miscarriage into a tragedy. "' Nor do such couples require "skilled psychotherapeutic help. "' The skills for supporting people after a personal loss are widely available among family, friends, and health care professionals and should not be allowed to be monopolised by psychotherapists. The language used in this editorial in relation to spontaneous miscarriage surprises me. I fail to understand why the degree of personal care advocated for couples bereaved in the second and third trimesters of pregnancy should not be extended to the first. For too long the feelings experienced by couples after early pregnancy loss have been dismissed too quickly by the medical profession. MICHAEL J TURNER
Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy.

BACKGROUND Recently, increasing numbers of women receiving adjuvant chemotherapy for breast cancer have also received granulocyte colony-stimulating factors (G-CSFs) or granulocyte-macrophage colony-stimulating factors (GM-CSFs). Although these growth factors support chemotherapy, their long-term safety has not been evaluated. We studied the association between G-CSF use and incidence of leukemia in a population-based sample of breast cancer patients. METHODS Among women aged 65 years or older in the Surveillance, Epidemiology, and End Results-Medicare database who were diagnosed with stages I-III breast cancer from January 1, 1991, to December 31, 1999, we identified those who received G-CSF or GM-CSF concurrently with chemotherapy. We used Cox proportional hazards models to estimate hazard ratios for the association of treatment with G-CSF or GM-CSF and subsequent (through December 31, 2003) diagnosis of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). All statistical tests were two-sided. RESULTS Of 5510 women treated with chemotherapy, 906 (16%) received G-CSF or GM-CSF therapy, and 64 (1.16%) were subsequently diagnosed with either MDS or AML before a cancer recurrence. Use of G-CSF and GM-CSF was associated with more recent diagnosis, younger age, urban residence, fewer comorbidities, receipt of radiation therapy, positive lymph nodes, and cyclophosphamide treatment. Of the 906 patients who were treated with G-CSF, 16 (1.77%) developed AML or MDS; of the 4604 patients not treated with G-CSF, 48 (1.04%) developed AML or MDS. The hazard rate ratio for AML or MDS among those treated with G-CSF or GM-CSF compared with those who were not was 2.14 (95% confidence interval [CI] = 1.12 to 4.08). AML or MDS developed within 48 months of breast cancer diagnosis in 1.8% of patients who received G-CSF or GM-CSF but only in 0.7% of patients who did not (hazard ratio = 2.59, 95% CI = 1.30 to 5.15). CONCLUSIONS The use of G-CSF was associated with a doubling in the risk of subsequent AML or MDS among the population that we studied, although the absolute risk remained low. Even if this association is confirmed, the benefits of G-CSF may still outweigh the risks. Meanwhile, however, G-CSF use should not be assumed to be risk free.
Effect of dietary protein sources on production performance, egg quality, and plasma parameters of laying hens

Objective This study was conducted to evaluate the effects of dietary protein sources (soybean meal, SBM; low-gossypol cottonseed meal, LCSM; double-zero rapeseed meal, DRM) on laying performance, egg quality, and plasma parameters of laying hens. Methods A total of 432 32-wk-old laying hens were randomly divided into 6 treatments with 6 replicates of 12 birds each. The birds were fed diets containing SBM, LCSM100, or DRM100 individually or in combination with an equal amount of crude protein (CP) (LCSM50, DRM50, and LCSM50-DRM50). The experimental diets, which were isocaloric (metabolizable energy, 11.11 MJ/kg) and isonitrogenous (CP, 16.5%), had similar digestible amino acid profile. The feeding trial lasted 12 weeks. Results The daily egg mass was decreased in the LCSM100 and LCSM50-DRM50 groups (p<0.05) in weeks 41 to 44. The LCSM50 group did not affect egg production compared to the SBM group in weeks 41 to 44 (p>0.05) and showed increased yolk color at the end of the trial (p<0.05). Compared to the SBM group, the LCSM100 and LCSM50-DRM50 groups showed decreased albumen weight (p<0.05), CP weight in the albumen (p<0.05) and CP weight in the whole egg (p<0.05) at 44 weeks. Plasma total protein (TP) levels were lower in the LCSM100 group than in the SBM group at 44 weeks (p<0.05); however, TP, albumin, and globulin levels were not significantly different between the LCSM50 group and the SBM group or between the DRM50 group and the SBM group (p>0.05). Conclusion Together, our results suggest that the LCSM100 or DRM100 diets may produce the adverse effects on laying performance and egg quality after feeding for 8 more weeks. The 100.0 g/kg LCSM diet or the148.7 g/kg DRM diet has no adverse effects on laying performance and egg quality.
Using a Contrast-Enhanced Imaging Sequence at 3-Minute Delay in 3-T Magnetic Resonance Imaging for Acute Infarct Evaluation

Objectives:To investigate the performance of a delayed-enhancement (DE) sequence adapted for a 3-minute delay after bolus injection of a contrast media in cardiac magnetic resonance imaging (MRI) in acute reperfused myocardial infarction. Materials and Methods:Sixty-three patients with recent myocardial infarction underwent contrast-enhanced MRI. Sequences of first-pass (FP) perfusion imaging and DE imaging at 3 and 15 minutes were performed at the acute phase. Of these patients, 49 had a follow-up cardiac magnetic resonance examination. Infarct sizes were quantified by 2 experienced users with a 17-segment model at the acute phase (at FP and at 3- and 15-minute delay) and at the chronic phase (at 15 minutes because only fibrous areas hyperenhance late). Areas of hypoenhancement and hyperenhancement were also calculated. Results from the 3-minute imaging sequence at the acute phase were compared with the FP (taking into account dark signal areas), with the 15-minute DE imaging sequence results at the acute phase [taking into account dark signal and hyperenhanced (white plus dark signal) areas] and with the 15-minute DE imaging sequence from the chronic phase (taking into account hyperenhanced areas). Least squares regression and Bland-Altman plots were performed for the comparisons. Results:For the evaluation of hyperenhancement, the comparison between imaging sequence results at 3 minutes versus 15-minute DE at the acute phase (respectively, at the chronic phase) shows a good correlation (r2 = 0.941; respectively r2 = 0.862, at the chronic phase) and the Bland-Altman plot indicates a good concordance (m =−0.43; SD = 2.69; respectively m = 2.76; SD = 3.92); For the evaluation of hypoenhancement, the comparison between imaging sequence results at 3 minutes versus FP (respectively, 15 minutes at the acute phase) also shows a good correlation (r2 = 0.751; respectively r2 = 0.71) and the Bland-Altman plot indicates a good concordance (m = −1.06; SD = 3.34; respectively m = 2.90; SD = 3.11). Finally, the interobserver study provides a very good kappa coefficient (κ = 0.82), and good kappa coefficients from the intraobserver study (κ1 = 0.78 and κ2 = 0.86). Conclusions:The use of a delayed contrast-enhanced sequence adapted for a 3-minute delay after the bolus injection has the potential to obtain quickly reliable information comparable with the perfusion delay at FP and reliable information from the infarct size at 15 minutes and at the chronic phase.
Human chorionic gonadothropin levels in maternal blood in late pregnancy: relation to birth weight, sex and condition of the infant at birth

Summary. A total of 527 blood samples was obtained from an unselected population of women between 36 and 40 weeks gestation. Serum human chorionic gonadotrophin (hCG) levels were measured using a specific radioimmunoassay for the (β1‐subunit of hCG. Serum hCG levels were higher in primigravidae and in women carrying female fetuses. They were also related to the birthweight of the child and to the occurrence of fetal distress.
Closure or Non-Closure of Peritoneum in Cesarean Section: Outcomes of Short-Term Complications

Background Cesarean section (CS) is one of the most frequently performed surgical procedures worldwide. The complications following a CS include fever, wound infection, post-operative pain and bleeding which are not usually found in a normal vaginal delivery. Traditionally, suturing of peritoneal layers for CS patients has been done, but in some studies it has been shown that this procedure could be eliminated without affecting the rate of morbidity. Objectives The objective of this study was to assess the short-term outcomes of two different cesarean delivery techniques. Patients and Methods A total of 100 cases who underwent CS were randomly assigned equally to either closure of both the visceral and parietal peritoneum or no peritoneum closure. Duration of operation, pain scores, analgesic requirements, alterations in hemoglobin levels and febrile morbidity were assessed accordingly. Results Pain scores, analgesic requirements assessed at 24 hours and operation duration were significantly lower in the non-closure group as compared to the closure group. Febrile conditions and changes in hemoglobin levels were similar in both groups. Conclusions Non-closure of both visceral and the parietal peritoneum when performing a CS produces a significant reduction in pain, fewer analgesic requirements and a shorter operation duration without increasing the febrile morbidity and changes in hemoglobin levels as compared to the standard methods.
Aerodynamic Testing of Helicopter Side Intake Retrofit Modifications

Aerodynamic characteristics of helicopter engine side air intakes are investigated. The experimental data set is obtained by wind tunnel testing of a full-scale helicopter fuselage section model. For the simulation of realistic engine operation, engine mass flow rates are reproduced. Five-hole pressure probe data of the aerodynamic interface plane as well as local surface pressure distributions are compared for different geometries and operation conditions. Previous investigations indicate that unshielded, sideways-facing air intakes yield lowest distortion and highest total pressure levels in low speed conditions. In fast forward flight condition, however, forward-facing intake shapes are more beneficial. On this basis, the current research assesses the optimization potential of retrofit modifications such as a rear spoiler (small scoop) and an intake guide vane. Two optimal configurations of retrofit modifications are identified, combining benefits of the various basic intake and plenum chamber shapes.
An Analysis of the Risk of Hip Dislocation with a Contemporary Total Joint Registry

Dislocation rates after total hip arthroplasty in a community setting have not been well documented. We used a community based joint registry to evaluate hip dislocations that occurred within 1 year after total hip arthroplasty. We evaluated patient, implant, and technical factors associated with dislocation, including primary versus revision surgery, femoral head size (28 mm versus ≥ 32 mm), operative time, surgeon volume, surgical approach, age, gender, diagnosis, American Society of Anesthesiologists (ASA) classification, and body mass index (BMI). There were 1693 primary total hip arthroplasties and 277 revision procedures performed from 2001-2003. The overall dislocation rate was 1.7% for primary total hip arthroplasties and 5.1% for revision procedures. Patients with ASA scores of 3 or 4 had a 2.3-fold dislocation increase compared with patients with scores of 1 or 2. Patients with rheumatoid arthritis had an increased risk of dislocation. The dislocation rates for primary total hip arthroplasty were 2% for 28 mm heads and 0.7% for heads ≥ 32 mm. The surgeon's patient volume, surgical approach, operative time, and body mass index had no effect on dislocation.Level of Evidence: Prognostic study, level III. See Guidelines for Authors for a complete description of levels of evidence.
Split-Thickness Skin Grafts for Closure of Diabetic Foot and Ankle Wounds

The aim of this study was to determine if split-thickness skin grafts could be successfully used for closure of foot and ankle wounds in diabetic patients. The authors retrospectively reviewed the charts of 100 consecutive patients who underwent a soft tissue surgical reconstruction with split-thickness skin grafts to their foot and/or ankle in our institution from 2005 to 2008. After application of inclusion criteria, 83 eligible charts remained. Of the 83 patients, 54 (65%) healed uneventfully, 23 (28%) required regrafting, and 6 (7%) had a complication resolved with conservative management. All patients had a successful surgical outcome, defined as having achieved complete wound closure at the final follow-up. Surgical outcome was not significantly associated with age, gender, race, hemoglobin A1C, wound size, wound location, illicit drug use, amputation history, Charcot history, or preoperative infection. However, postoperative graft complications were significantly associated with current or previous smoking history (P = .016) and the level of previous pedal amputation to which the split-thickness skin graft was applied (P = .009). This study demonstrates that application of split-thickness skin grafts with an appropriate postoperative regimen is a beneficial procedure to achieve foot and ankle wound closure in diabetic patients.
Augmentative Message Passing for Traveling Salesman Problem and Graph Partitioning

The cutting plane method is an augmentative constrained optimization procedure that is often used with continuous-domain optimization techniques such as linear and convex programs. We investigate the viability of a similar idea within message passing – for integral solutions in the context of two combinatorial problems: 1) For Traveling Salesman Problem (TSP), we propose a factor-graph based on Held-Karp formulation, with an exponential number of constraint factors, each of which has an exponential but sparse tabular form. 2) For graph-partitioning (a.k.a. community mining) using modularity optimization, we introduce a binary variable model with a large number of constraints that enforce formation of cliques. In both cases we are able to derive simple message updates that lead to competitive solutions on benchmark instances. In particular for TSP we are able to find near-optimal solutions in the time that empirically grows with N3, demonstrating that augmentation is practical and efficient.
The Phosphatidylinositol 4,5-Biphosphate and TORC2 Binding Proteins Slm1 and Slm2 Function in Sphingolipid Regulation

ABSTRACT The Stt4 phosphatidylinositol 4-kinase has been shown to generate a pool of phosphatidylinositol 4-phosphate (PI4P) at the plasma membrane, critical for actin cytoskeleton organization and cell viability. To further understand the essential role of Stt4-mediated PI4P production, we performed a genetic screen using the stt4ts mutation to identify candidate regulators and effectors of PI4P. From this analysis, we identified several genes that have been previously implicated in lipid metabolism. In particular, we observed synthetic lethality when both sphingolipid and PI4P synthesis were modestly diminished. Consistent with these data, we show that the previously characterized phosphoinositide effectors, Slm1 and Slm2, which regulate actin organization, are also necessary for normal sphingolipid metabolism, at least in part through regulation of the calcium/calmodulin-dependent phosphatase calcineurin, which binds directly to both proteins. Additionally, we identify Isc1, an inositol phosphosphingolipid phospholipase C, as an additional target of Slm1 and Slm2 negative regulation. Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization.