Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigenetic Histone Deacetylation Inhibition Prevents the Development and Persistence of Temporal Lobe Epilepsy

Epilepsy is a chronic brain disease characterized by repeated unprovoked seizures. Currently, no drug therapy exists for curing epilepsy or disease modification in people at risk. Despite several emerging mechanisms, there have been few studies of epigenetic signaling in epileptogenesis, the process whereby a normal brain becomes progressively epileptic because of precipitating factors. Here, we report a novel role of histone deacetylation as a critical epigenetic mechanism in epileptogenesis. Experiments were conducted using the histone deacetylase (HDAC) inhibitor sodium butyrate in the hippocampus kindling model of temporal lobe epilepsy (TLE), a classic model heavily used to approve drugs for treatment of epilepsy. Daily treatment with butyrate significantly inhibited HDAC activity and retarded the development of limbic epileptogenesis without affecting after-discharge signal. HDAC inhibition markedly impaired the persistence of seizure expression many weeks after epilepsy development. Moreover, subchronic HDAC inhibition for 2 weeks resulted in a striking retardation of epileptogenesis. HDAC inhibition, unexpectedly, also showed erasure of the epileptogenic state in epileptic animals. Finally, butyrate-treated animals exhibited a powerful reduction in mossy fiber sprouting, a morphologic index of epileptogenesis. Together these results underscore that HDAC inhibition prevents the development of TLE, indicating HDAC’s critical signaling role in epileptogenesis. These findings, therefore, envisage a unique novel therapy for preventing or curing epilepsy by targeting the epigenetic HDAC pathway.
The Global Program on Youth: Lessons Learned from Collaboratories in Action

ABSTRACT The Global Program on Youth (GPY) employs a technology-supported, collaborative framework of problem solving, called a collaboratory, to improve the lives of children and youth. Collaboratory partners use technology to share research, apply practice wisdom, and learn from the experiences and perspectives of diverse groups of people. Findings from the initiative are presented in this article, highlighting the lessons learned from each of the participating collaboratories, including the rewards, challenges, and applications of technology-supported collaboration.
Asking the Right Questions: What Does Research Tell Us About Technology and Higher Learning?

been involved with innovation in higher education its funding, its evaluation, and research about it for 20 years, especially innovations having to do with computing, video, and telecommunications. During that time I've often been asked: "What do computers teach best? " "Does video encourage passive learning? " "Is it cheaper to teach with telecommunications? " I don't have answers to those questions. I don't think they can be answered in any reliable, valid way. It takes just as much effort to answer a useless question as a useful one. The quest for useful information about technology has to begin, then, with thought about just what are the right questions. This article not only illustrates what I mean by "useless" questions, but discusses a few of the useful ones (and the findings that hjive resulted from their being asked), as well as one type of question that ought to be asked next about how we use technology for learning.
Early Levallois technology and the Lower to Middle Paleolithic transition in the Southern Caucasus

An early assemblage of obsidian artifacts Levallois technology is the name for the stone knapping technique used to create tools thousands of years ago. The technique appeared in the archeological record across Eurasia 200 to 300 thousand years ago (ka) and appeared earlier in Africa. Adler et al. challenge the hypothesis that the technique's appearance in Eurasia was the result of the expansion of hominins from Africa. Levallois obsidian artifacts in the southern Caucasus, dated at 335 to 325 ka, are the oldest in Eurasia. This suggests that Levallois technology may have evolved independently in different hominin populations. Stone technology cannot thus be used as a reliable indicator of Paleolithic human population change and expansion. Science, this issue p. 1609 An assemblage of obsidian artifacts suggests independent origins of stone knapping in different hominin populations. The Lower to Middle Paleolithic transition (~400,000 to 200,000 years ago) is marked by technical, behavioral, and anatomical changes among hominin populations throughout Africa and Eurasia. The replacement of bifacial stone tools, such as handaxes, by tools made on flakes detached from Levallois cores documents the most important conceptual shift in stone tool production strategies since the advent of bifacial technology more than one million years earlier and has been argued to result from the expansion of archaic Homo sapiens out of Africa. Our data from Nor Geghi 1, Armenia, record the earliest synchronic use of bifacial and Levallois technology outside Africa and are consistent with the hypothesis that this transition occurred independently within geographically dispersed, technologically precocious hominin populations with a shared technological ancestry.
Structure and asymptotic expansion of multiple harmonic sums

We prove that the algebra of multiple harmonic sums is isomorphic to a shuffle algebra. So the multiple harmonic sums Hs, indexed by the compositions s=(s1,.,sr), are ℝ-linearly independent as real functions defined over ℕ. We deduce then the algorithm to obtain the asymptotic expansion of multiple harmonic sums.
Does more sequence data improve estimates of galliform phylogeny? Analyses of a rapid radiation using a complete data matrix

The resolution of rapid evolutionary radiations or “bushes” in the tree of life has been one of the most difficult and interesting problems in phylogenetics. The avian order Galliformes appears to have undergone several rapid radiations that have limited the resolution of prior studies and obscured the position of taxa important both agriculturally and as model systems (chicken, turkey, Japanese quail). Here we present analyses of a multi-locus data matrix comprising over 15,000 sites, primarily from nuclear introns but also including three mitochondrial regions, from 46 galliform taxa with all gene regions sampled for all taxa. The increased sampling of unlinked nuclear genes provided strong bootstrap support for all but a small number of relationships. Coalescent-based methods to combine individual gene trees and analyses of datasets that are independent of published data indicated that this well-supported topology is likely to reflect the galliform species tree. The inclusion or exclusion of mitochondrial data had a limited impact upon analyses upon analyses using either concatenated data or multispecies coalescent methods. Some of the key phylogenetic findings include support for a second major clade within the core phasianids that includes the chicken and Japanese quail and clarification of the phylogenetic relationships of turkey. Jackknifed datasets suggested that there is an advantage to sampling many independent regions across the genome rather than obtaining long sequences for a small number of loci, possibly reflecting the differences among gene trees that differ due to incomplete lineage sorting. Despite the novel insights we obtained using this increased sampling of gene regions, some nodes remain unresolved, likely due to periods of rapid diversification. Resolving these remaining groups will likely require sequencing a very large number of gene regions, but our analyses now appear to support a robust backbone for this order.
SOLUBILITY OF IRON IN METALLIC HYDROGEN AND STABILITY OF DENSE CORES IN GIANT PLANETS

The formation of the giant planets in our solar system, and likely a majority of giant exoplanets, is most commonly explained by the accretion of nebular hydrogen and helium onto a large core of terrestrial-like composition. The fate of this core has important consequences for the evolution of the interior structure of the planet. It has recently been shown that H2O, MgO, and SiO2 dissolve in liquid metallic hydrogen at high temperature and pressure. In this study, we perform ab initio calculations to study the solubility of an innermost metallic core. We find dissolution of iron to be strongly favored above 2000 K over the entire pressure range (0.4–4 TPa) considered. We compare with and summarize the results for solubilities on other probable core constituents. The calculations imply that giant planet cores are in thermodynamic disequilibrium with surrounding layers, promoting erosion and redistribution of heavy elements. Differences in solubility behavior between iron and rock may influence evolution of interiors, particularly for Saturn-mass planets. Understanding the distribution of iron and other heavy elements in gas giants may be relevant in understanding mass–radius relationships, as well as deviations in transport properties from pure hydrogen–helium mixtures.
Political Attitudes over the Life Span: The Bennington Women After Fifty Years

The culmination of one of the most famous long-term studies in American sociology, this examination of political attitudes among women who attended Bennington College in the 1930s and 1940s now spans five decades, from late adolescence to old age. Theodore Newcomb s 1930s interviews at Bennington, where the faculty held progressive views that contrasted with those of the conservative families of the students, showed that political orientations are still quite malleable in early adulthood. The studies in 1959-60 and 1984 show the persistence of political attitudes over the adult life span: the Bennington women, raised in conservative homes, were liberalized in their college years and have remained politically involved and liberal in their views, even in their sixties and seventies. Here the authors analyze the earlier studies and then introduce the 1984 data. Using data from National Election Studies for comparison, they show that the Bennington group is more liberal and hold its opinions more intensely than both older and younger Americans, with the exception of the generation that achieved political maturity in the 1960s. The authors point out that the majority of the Bennington women s children are of this 1945 54 generation and suggest that this factor played an important role in the stability of the women s political views. Within their own generation, the Bennington women also appear to hold stronger political views than other college-educated women. Innovative in its methodology and extremely rich in its data, this work will contribute to developmental and social psychology, sociology, political science, women s studies, and gerontology. "
Multiple Antigenic Specificities of Serum Lipoproteins Detected with Sera of Transfused Patients

1 Precipitins were found in the sera of 18 patients who had received multiple transfusions. 2 The precipitins reacted with a lipid‐containing serum protein present in some individuals, but not others. Using two of the antisera, the antigen was shown to be a low density beta lipoprotein. 3 The frequency of precipitin formation appears to be higher in transfused patients with thalassemia than in other transfused patients. 4 There is no apparent correlation between formation of antibodies to lipoproteins and to white blood cells, red blood cells and platelets. 5 Using two immunological and one epidemiological technique, it was shown that there were at least five and possibly seven different specificities among eleven of the antisera which were tested.
Should Psychosocial Safety Climate Theory Be Extended to Include Climate Strength?

Psychosocial safety climate (PSC; climate for psychological health) is an organizational antecedent to work conditions articulated in the job demands–resources model. We responded to calls for broader consideration of organizational climate in terms of both climate level and strength. We tested PSC level and strength as main and interactive predictors of work conditions, psychological health, and engagement. Using multilevel analysis and cross-sectional data, the effects of unit-level PSC constructs were investigated in 21 hospital work units (n = 249 employees) in Australia. The correlation between PSC levels (measured at the unit mean) and PSC strength (measured as unit −1 × SD) was moderate and positive, suggesting that ceiling effects of PSC scores were not problematic. PSC level was a better predictor than PSC strength or their interactions for job demands (psychological and emotional demands), job resources (e.g., skill discretion and organizational support), and health (emotional exhaustion). For engagement, the interaction was significant—improving engagement, therefore, benefits from high levels of PSC and PSC strength within the work units. So, in answer to the research question regarding PSC theory extension, “it depends on the outcome. ” Research limitations are acknowledged, and the potential of the PSC model to guide the reduction of workplace psychosocial risk factors and the negative consequences is discussed.
The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts

The retinoblastoma (RB) tumor suppressor is known as a master regulator of the cell cycle. RB is mutated or functionally inactivated in the majority of human cancers. This transcriptional regulator exerts its function in cell cycle control through its interaction with the E2F family of transcription factors and with chromatin remodelers and modifiers that contribute to the repression of genes important for cell cycle progression. Over the years, studies have shown that RB participates in multiple processes in addition to cell cycle control. Indeed, RB is known to interact with over 200 different proteins and likely exists in multiple complexes. RB, in some cases, acts through its interaction with E2F1, other members of the pocket protein family (p107 and p130), and/or chromatin remodelers and modifiers. RB is a tumor suppressor with important chromatin regulatory functions that affect genomic stability. These functions include the role of RB in DNA repair, telomere maintenance, chromosome condensation and cohesion, and silencing of repetitive regions. In this review we will discuss recent advances in RB biology related to RB, partner proteins, and their non-transcriptional functions fighting back against genomic instability.
Comparing the T scores from bone sonometer measurements in Hispanic and non-Hispanic white women

Ethnicity is an important risk factor for the development of osteoporosis. Non-Hispanic white or Asian women are commonly considered at higher risk than other ethnicities. Hispanics in the U.S. are of Mexican, Caribbean, Central American, or South American descent. Conclusive data on the relative risk of osteoporosis in Hispanic women based upon heritage within the Hispanic population are not available. Objective To investigate whether Hispanic white women are at a significantly lower risk than non- Hispanic whites for the development of osteoporosis. Methods Cross-sectional study. Setting: Community health screenings. Participants: Hispanic and non-Hispanic white women. Intervention: Bone density measurements of the non-dominant heel. Descriptive statistics and inferential statistics including regression analyses were performed using SPSS 14.0. Main Outcomes Measure: T scores. Results Overall, measurements were obtained from 352 women (209 Hispanic & 143 non-Hispanic white) ranging in age from 55-97 years old. The mean T score obtained for Hispanic women was - 1.194 and -1.280 for non-Hispanic white women. The correlation between the obtained T score and age was negative (r = -0.36, p<0.01), reflecting bone loss with increasing age. Regression analysis using age and ethnicity showed that ethnicity was a non-significant contributor to the best-fit regression line (t=0.60, p=0.55). Conclusion This study indicates that Hispanic white women may be at comparable risk of developing osteoporosis as non-Hispanic white women.
Nickel-Doped Ceria Nanoparticles: The Effect of Annealing on Room Temperature Ferromagnetism

Nickel-doped cerium dioxide nanoparticles exhibit room temperature ferromagnetism due to high oxygen mobility within the doped CeO2 lattice. CeO2 is an excellent doping matrix as it can lose oxygen whilst retaining its structure. This leads to increased oxygen mobility within the fluorite CeO2 lattice, leading to the formation of Ce3+ and Ce4+ species and hence doped ceria shows a high propensity for numerous catalytic processes. Magnetic ceria are important in several applications from magnetic data storage devices to magnetically recoverable catalysts. We investigate the effect doping nickel into a CeO2 lattice has on the room temperature ferromagnetism in monodisperse cerium dioxide nanoparticles synthesised by the thermal decomposition of cerium(III) and nickel(II) oleate metal organic precursors before and after annealing. The composition of nanoparticles pre- and post-anneal were analysed using: TEM (transmission electron microscopy), XPS (X-ray photoelectron spectroscopy), EDS (energy-dispersive X-ray spectroscopy) and XRD (X-ray diffraction). Optical and magnetic properties were also studied using UV/Visible spectroscopy and SQUID (superconducting interference device) magnetometry respectively.
Integrating Trait and Social-Cognitive Views of Personality: Neuroticism, Implicit Stress Priming, and Neuroticism-Outcome Relationships

The trait perspective of personality emphasizes the broad role of traits in outcome prediction, whereas the social-cognitive perspective emphasizes the importance of if—then intrapsychic associations. Three studies (N = 188) were conducted to reconcile these alternative views of personality in the context of stress-related behaviors. Implicit priming tasks were used to quantify the extent to which stress primes activated thoughts of aggression (Studies 1 and 2) or eating (Study 3), and trait levels of neuroticism were also assessed. Neuroticism did not consistently predict stress-related implicit associations, consistent with the independence of these predictors. Of more importance, such implicit associations predicted problematic outcomes (e.g., physical aggression), but only to the extent that relevant individuals were also high in neuroticism. The results highlight an interface of trait and social-cognitive views of personality and do so in the context of understanding stress-reactivity processes, a topic of importance to multiple literatures.
Evidence of porcine and human endothelium activation by cancer‐associated carbohydrates expressed on glycoproteins and tumour cells

It is well established that after metastatic cancer cells escape the primary tumour and enter the circulation, their interactions with microvascular endothelium of a target organ constitute an essential rate‐limiting step in haematogenous cancer metastasis. However, the physiological and biochemical processes supporting neoplastic cell arrest and retention in the microcirculation are still poorly understood. In this study, we present experimental evidence that microvascular endothelium of metastasis‐prone tissues undergoes activation in response to desialylated cancer‐associated carbohydrate structures such as Thomsen–Friedenreich (TF) antigen (Galβ1–3GalNAc) expressed on circulating glycoproteins and neoplastic cells. The metastasis‐associated endothelium activation, manifested by marked increase in endothelial cell surface galectin‐3 expression, causes gradual decrease in cancer cell velocities (from 72 × 102± 33 × 102μm s−1 to 7.6 × 102± 1.9 × 102μm s−1, mean ±s.d.) accompanied by a corresponding increase in the percentage of rolling cells (from 3.3%± 1.2% to 24.3%± 3.6%, mean ±s.d.), and results in human breast and prostate carcinoma cell arrest and retention in the microvasculature. This process, which could be of high importance in haematogenous cancer metastasis, was inhibited efficiently by an anti‐TF antigen function‐blocking antibody. Carbohydrate‐mediated endothelial activation could be a process of physiological significance as it probably occurs in the interactions between a variety of circulating constituents and the vessel wall.
In Vivo Screening for Anti-Osteoporotic Fraction from Extract of Herbal Formula Xianlinggubao in Ovariectomized Mice

Background and Objectives Traditional Chinese Medicine (TCM) Fufang or formula Xianlinggubao (XLGB) is a prescribed TCM drug in China registered for prevention and treatment of osteoporosis. Fufang in TCM is comprised of a group of herbal compounds contributing in group to the treatment efficacy. The present study aims to identify the bioactive fraction(s) in XLGB extract that account(s) dominantly for its osteogenic effects. Methods The extract of XLGB formula was separated into three fractions using chromatography, i.e., XLGB-A, XLGB-B and XLGB-C. They were administrated to 4-month old ovariectomized (OVX) mice for 6 weeks to determine which bioactive fraction(s) were more effective for preventing OVX-induced bone loss evaluated by microCT, biomechanical testing and biochemical markers. The main peaks of the key fraction were identified using reference compounds isolated from the fraction. In addition, the effects of the composite compounds in XLGB-B on osteoblasts’ proliferation and mineralization were evaluated in UMR 106 cells. Results XLGB-B with a yield of 13.0% from herbal Fufang XLGB was identified as the most potential one among the three fractions for prevention of OVX-induced bone loss confirmed with bone mass, bone microarchitecture, bone strength and bone turnover markers. Nine compounds in HPLC fingerprint were identified in the XLGB-B fraction, including phenylpropanoids from Herba Epimedii, terpenes from Radix Dipsaci and coumarins from Fructus Psoraleae. In addition, the identified compounds effectively promoted proliferation and/or mineralization of osteoblast-like UMR 106 cells in vitro. Conclusion XLGB-B with defined phytochemical structures was screened as the key fraction that demonstrated preventive effects on OVX-induced bone loss in mice. The present study laid down a foundation towards a new generation of herbal Fufang characterized with “less herbal materials for achieving equal treatment efficacy” in development strategy of TCM for prevention of OVX-induced osteoporosis.
Optical Flow via Locally Adaptive Fusion of Complementary Data Costs

Many state-of-the-art optical flow estimation algorithms optimize the data and regularization terms to solve ill-posed problems. In this paper, in contrast to the conventional optical flow framework that uses a single or fixed data model, we study a novel framework that employs locally varying data term that adaptively combines different multiple types of data models. The locally adaptive data term greatly reduces the matching ambiguity due to the complementary nature of the multiple data models. The optimal number of complementary data models is learnt by minimizing the redundancy among them under the minimum description length constraint (MDL). From these chosen data models, a new optical flow estimation energy model is designed with the weighted sum of the multiple data models, and a convex optimization-based highly effective and practical solution that finds the optical flow, as well as the weights is proposed. Comparative experimental results on the Middlebury optical flow benchmark show that the proposed method using the complementary data models outperforms the state-of-the art methods.