Miracle-dz/UniFAR-FTUs huggingface dataset:
Black Racial Identity and Psychosocial Competence: A Preliminary Study

This study investigated whether Black racial identity attitudes predict psychosocial competence as defined by Tyler's tridimensional model. In particular, two aspects of Tyler's model of psychosocial competence were examined: self-attitudes and behavioral attitudes. Participants in this study were 103 (65 females, 38 males) Black undergraduates who completed the Black Racial Identity Attitude Scale, the Behavioral Attributes of Psychosocial Competence Scale, and Rotter's Internal-External Locus of Control Scale. The study found gender differences in racial identity attitudes for the sample. However, multiple regression analyses found that Black racial identity attitudes are not associated with one's sense of psychosocial competence. Although the results were not significant, analyses of individual / weights within the regression equations suggested that the influence of racial identity attitudes on psychosocial competence may operate differently for men and women.
Knockdown of CDK2AP1 by RNA interference inhibits cell growth and tumorigenesis of human glioma

Abstract Previous reports support the role of cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) as a tumor suppressor that functions as a key player in cell cycle regulation. Although the misadjustment of CDK2AP1 has been revealed in several types of human malignancies, the functional role of CDK2AP1 in human glioma remains unknown. The present study was undertaken to investigate the effects of CDK2AP1 knockdown by RNA interference (RNAi) on glioma cell growth and tumorigenesis. We employed lentivirus-mediated RNAi to down-regulate CDK2AP1 expression in U251 and U373 cells. Knockdown of CDK2AP1 resulted in a significant reduction in U251 and U373 cell proliferation, as determined by MTT and colony formation assays. Cell cycle analysis showed CDK2AP1 silencing caused U251 cells arrest in G0/G1 phase, especially in the sub-G1 phase representing apoptotic cells. In vivo tumorigenesis was assessed using xenograft formation and CDK2AP1 depletion remarkably inhibited glioma growth and tumorigenesis. Taken together, these results suggest that CDK2AP1 siRNA may have an anti-tumorigenic effect on human glioma.
Leading Psychoeducational Groups for Children and Adolescents

Table of Contents Ch 1: Introduction Goals of This Book How This Book is Organized What are Psychoeducational Groups and How are They Different From Other Types of Groups? How are Children and Adolescent Groups Different From Adult Groups? Summary Suggested Training Activities Ch 2: Planning for a Psychoeducational Group for Children and Adolescents PreGroup Decision Making Outline and Content of Group Sessions Agency and School Support Recruitment Strategies Leader Preparation Supervision Summary Suggested Training Activities Ch 3: PreGroup Interviews and Group Sessions Informed Consent for Parents and Children Screening Interviews Preparation Sessions Summary Suggested Training Activities Ch 4: Group Leadership Skills for Psychoeducational Groups Specific Skills Therapeutic Factors Training Assessment Measures Summary Suggested Training Activities Ch 5: Initial Sessions Goals and Tasks Skills Therapeutic Factors Possible Pitfalls Examples of Activities Summary Suggested Training Activities Ch 6: Middle Sessions Goals and Tasks Skills Therapeutic Factors Possible Pitfalls Examples of Activities Summary Suggested Training Activities Ch 7: Termination Sessions Goals and Tasks Skills Therapeutic Factors Possible Pitfalls Examples of Activities Summary Suggested Training Activities Ch 8: Using Activities Effectively in Group Sessions Common Mistakes in Using Activities Uses of Activities Related to Group Tasks Creative Arts Activities Effective Processing of Activities Summary Suggested Training Activities Ch 9: Follow-up After Group Ends Assessment of Progress Assessment of Need for Further Treatment Interview Sessions Referral for Further Treatment Summary Suggested Training Activities Ch 10: Assessment of Group Effectiveness Guidelines Assessment of Group Climate Assessment of Group Therapeutic Factors Assessment of In-Session Group Behavior Summary Suggested Training Activities Ch 11: Considerations Multicultural Issues Developmental Issues Summary Suggested Training Activities Ch 12: Conclusions APPENDICES Appendix A: ASGW Professional Standards for Training of Group Workers Appendix B: ASGW Best Practice Guidelines Appendix C: ASGW Principles for Diversity-Competent Group Workers Appendix D: Group Planning Sheets Appendix E: Group Processing Sheets Appendix F: Examples of Group Planning and Processing Session Notes for a Psychoeducational Children of Divorce Group Appendix G: Resource Guide for Group Interventions by Topic Including Books, Games, and Videos Appendix H: Example of Group Interest Survey Form Appendix I: Example of an Informational Sheet for Parents About Psychoeducational Groups Appendix J: Example of a Group Screening Interview Outline Appendix K: Example of a Group Preparation Session Outline Appendix L: Example of a Parent and Group Member Consent Form for Psychoeducational Groups Appendix M: Group Related Measures References About the Author
Simplified 13C metabolic modeling for simplified measurements of cerebral TCA cycle rate in vivo

13C NMR spectroscopy is a unique tool to measure the cerebral tricarboxylic acid (TCA) cycle rate in vivo. The measurement relies on metabolic modeling of glutamate C3 and C4 enrichment time courses during a 13C‐glucose intravenous infusion. Usual metabolic models require the plasma glucose and 13C‐glucose time courses as input functions, as well as the knowledge of Michaelis‐Menten kinetics parameters governing passage through the blood‐brain barrier. It is shown in the present work that, when using an infusion protocol yielding a rapidly stable plasma glucose fractional enrichment, metabolic modeling can be simplified in such a manner that this additional information on input function and glucose transport is no longer required, significantly simplifying the measurement of cerebral TCA cycle rate in vivo. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
Violent Crimes in City Gangs

The urban street gang plays a central role in the imagery of violence currently being disseminated by the mass media. Testing the reality of this image requires careful empirical studies of actual gangs. A study involving 150 gangs in "Midcity," a slum district of an eastern metropolis, and focusing on seven gangs subject to intensive field observation, reveals marked differences between the public imagery and research-derived findings. While members of slum street gangs engaged in violent crime to a greater degree than middle- class adolescents, violence was not a central preoccupation of the gangs, and most "violent" crimes were of the less serious variety. Cruel or sadistic violence was rare; violence was seldom "senseless" or irrational. Property damage was rela tively uncommon. Participation in violent crimes had little to do with race, but was directly related to sex, age, and social status; most active were males of lower social status during late adolescence. The control of gang violence is seen to in volve techniques for altering motivations similar to those which undergird national wars.
Simulation and Measurement-Based Vehicle-to-Vehicle Channel Characterization: Accuracy and Constraint Analysis

In this paper, a deterministic channel model for vehicle-to-vehicle (V2V) communication is compared against channel measurement results collected during a V2V channel measurement campaign using a channel sounder. Channel metrics such as channel gain, delay and Doppler spreads, eigenvalue (EV) distribution, and antenna correlations are derived from the ray-tracing (RT) simulations as well as from the measurement data obtained from two different measurements in an urban four-way intersection. The channel metrics are compared separately for line-of-sight (LOS) and non-LOS (NLOS) situations. Most power contributions arise from the LOS component (if present) as well as from multipaths with single bounce reflections. Measurement and simulation results of the received power show a very good agreement in the presence of LOS, as most of the received power is carried by the LOS component. In NLOS, the difference is large because the ray-tracer is unable to capture some of the channel characteristics due to the underlying limitations of our ray-based propagation model. Despite the limitations, the model is suitable to characterize some, but not all, of the channel properties in a sufficient manner. We find that the diffuse scattering and multibounced nonspecular reflections must be considered for an accurate prediction of the channel in such a rich scattering environment.
Key Determinants of Student Satisfaction

Student life is seemingly a web of interrelated activities and experiences. This article examines which aspects of a student's educational experience are more important in influencing student satisfaction. The findings suggest that “student centeredness” and “instructional effectiveness” are key determinants of how satisfied a student is with his/her overall educational experience. Implications are included that should help universities enhance student satisfaction and student retention.
Quality of reporting of noninferiority and equivalence randomized trials.

CONTEXT Noninferiority and equivalence trials aim to show that the experimental treatment is not clinically worse than (noninferior) or clinically similar to (equivalent) a control active treatment. These study objectives imply particular planning and analysis. OBJECTIVE To assess the methodologic quality of reports of randomized controlled trials of noninferiority and equivalence. DESIGN We searched MEDLINE and the Cochrane Central Register of Controlled Trials for reports of randomized controlled trials of noninferiority and equivalence hypotheses published between January 1, 2003, and December 31, 2004. MAIN OUTCOME MEASURES Data extracted by use of a standardized form involved assessment of choice of noninferiority or equivalence margins, sample size calculation, sets of patients analyzed, method of statistical testing and reporting results, and conclusions. RESULTS A total of 162 reports were included in the analysis (116 reports of noninferiority and 46 of equivalence). The margin defining noninferiority or equivalence was described in most reports (156 [96.3%]), with justification of the margin in only 33 (20.4%). Almost one quarter of the reports (35 [21.6%]) did not describe a sample size calculation, and an additional 11 (6.8%) did not take into account a prespecified noninferiority or equivalence margin. Less than half of the reports (69 [42.6%]) described both an intent-to-treat (ITT; all randomized patients are included in the analysis) or modified ITT (patients who never received treatment are excluded) and per-protocol (patients who did not complete the treatment are excluded) analysis, and only about half of those (39 [56.5%]) described both types of results. Results were displayed with confidence intervals in 136 reports (84.0%). Only 33 articles (20.3%) fulfilled reporting requirements specific to noninferiority and equivalence trials, 4 of them (12.1%) with misleading conclusions. CONCLUSIONS Reporting of noninferiority and equivalence trials has important deficiencies: absence of noninferiority or equivalence margin, only an ITT (or a per-protocol) analysis performed, and results not adequately reported. Moreover, even for articles fulfilling these requirements, conclusions are sometimes misleading.
“They Saw a Terrorist”—Responses of Jewish-Israeli Viewers to an Interview with a Palestinian Terrorist

This study examines the responses of Jewish-Israeli viewers to an interview broadcast on Israel's national public TV network with a female Palestinian terrorist, caught by Israeli security services on her way to perform a suicide bombing in Israel. Viewers' (N = 47) written accounts of the viewing experience were qualitatively analyzed and found to reflect two conflicting representations of the terrorist in the interview. Some of the viewers' accounts corresponded to the hegemonic animosity frame, through which the terrorist was perceived as malicious, immoral, murderous, and as arousing anger, hate, and contempt. Still, other accounts corresponded with a more humanizing frame, through which the terrorist was seen as fragile, suffering, and sympathetic. Maybe the most striking result of this study is that the personalized portrayal of the Palestinian terrorist elicited—in 60% of the viewers—positive emotions toward her. This finding leads to the elaboration, in the Discussion section, of the possible effe.
The use of self-reports in psychiatric studies of traumatized refugees: Validation and analysis of HSCL-25

A consecutive sample of 231 refugee patients referred to the outpatient unit at the Psychosocial Centre for Refugees, University of Oslo, were examined by means of a semistructured clinical interview, the Brief Psychiatric Rating Scale (BPRS), and the self-reports Hopkins Symptoms Check List (HSCL-25) and a checklist for post-traumatic symptoms (PTSS-10). A significant relation was found between the self-report scores on the HSCL-25 and ratings made by the clinician on Global Assessment of Function Scale (GAF) and Global Rating on Brief Psychiatric Rating Scale (BPRS). A further analysis showed that HSCL-25 had a significant relation with mainly two of the four symptom patterns identified in a factor analysis of BPRS, namely Factor II (emotional withdrawal/retardation) and Factor III (anxiety/depression). Multiple regression analyses based on HSCL-25 scores for age, sex, nationality of origin, stay in prison, torture, exposure to war actions, refugee status, and employment situation in Norway showed a sig.
“I Ain't Gonna Let No One Disrespect Me”

The authors extended Elijah Anderson's “code of the street” thesis to explain victimization among a longitudinal sample of 720 African American adolescents from 259 neighborhoods. Specifically, the authors assessed whether the street code promotes greater safety or aggravates the risk for victimization. Anderson portrayed the code of the street, which encourages individuals to appear aggressive and tough, as an adaptation necessary for safely functioning in a disadvantaged, high-crime community. He theorized that adopting the street code promotes respect among one's peers and would-be attackers, thereby increasing one's safety against victimization. The authors found no support for the idea that adopting the street code reduces victimization. Instead, their findings suggest that individuals who adopt the street code have higher levels of victimization. Furthermore, adopting the street code exacerbates the risk for victimization beyond what would be the case from living in a dangerous and disorganized neighborhood.
On the entrainment coefficient in a forced plume: quantitative effects of source parameters

The behavior of a forced plume is mainly con- trolled by the source buoyancy and momentum fluxes and the efficiency of turbulent mixing between the plume and the ambient fluid (stratified or not). The interaction between the plume and the ambient fluid controls the plume dynam- ics and is usually represented by the entrainment coefficient E. Commonly used one-dimensional models incorporating a constant entrainment coefficient are fundamental and very useful for predictions in geophysical flows and industrial situations. Nevertheless, if the basic geometry of the flow changes, or the type of source or the environmental fluid conditions (e.g., level of turbulence, shear, ambient strati- fication, presence of internal waves), new models allowing for variable entrainment are necessary. The presented paper is an experimental study based on a set of turbulent plume experiments in a calm unstratified ambient fluid under dif- ferent source conditions (represented by different buoyancy and momentum fluxes). The main result is that the entrain- ment coefficient is not a constant and clearly varies in time within the same plume independently of the buoyancy and the source position. This paper also analyzes the influence of the source conditions on the mentioned time evolution. The measured entrainment coefficient E has considerable variability. It ranges between 0.26 and 0.9 for variable At- wood number experiments and between 0.16 and 0.55 for variable source position experiments. As is observed, values are greater than the traditional standard value of Morton et al. (1956) for plumes and jets, which is about 0.13.
Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitors

Radotinib (IY5511HCL), a novel and selective BCR-ABL1 tyrosine kinase inhibitor, has shown pre-clinical and phase I activity and safety in chronic myeloid leukemia. This phase II study investigated the efficacy and safety of radotinib in Philadelphia chromosome-positive chronic phase-chronic myeloid leukemia patients with resistance and/or intolerance to BCR-ABL1 tyrosine kinase inhibitors. Patients received radotinib 400 mg twice daily for 12 cycles based on results from the phase I trial. The primary end point was rate of major cytogenetic response by 12 months. A total of 77 patients were enrolled. Major cytogenetic response was achieved in 50 (65%; cumulative 75%) patients, including 36 (47%) patients with complete cytogenetic response by 12 months. Median time to major cytogenetic response and complete cytogenetic response were 85 days and 256 days, respectively. Major cytogenetic response and complete cytogenetic response rates were similar between imatinib-resistant and imatinib-intolerant patients, but were higher in patients without BCR-ABL1 mutations. Overall and progression-free survival rates at 12 months were 96.1% and 86.3%, respectively. All newly-occurring or worsening grade 3/4 hematologic abnormalities included thrombocytopenia (24.7%) and anemia (5.2%); grade 3/4 drug-related non-hematologic adverse events included fatigue (3.9%), asthenia (3.9%), and nausea (2.6%). The most common biochemistry abnormality was hyperbilirubinemia (grade 3/4 23.4%), and 12 of 18 cases were managed with dose modification. Study findings suggest radotinib is effective and well tolerated in chronic phase-chronic myeloid leukemia patients with resistance and/or intolerance to BCR-ABL1 tyrosine kinase inhibitors and may represent a promising alternative for these patients. (clinicaltrials.gov identifier: 01602952)
Congressional Voting over Legislative Careers: Shifting Positions and Changing Constraints

The proposed model predicts that voting behavior of legislators is more variable early in their career and that junior members are more likely to vote with their party than senior members. The results from the analysis of voting patterns in the House of Representatives and the Senate are consistent with the hypotheses: Party line voting and variability of voting decisions decline with increasing seniority. Changes in voting behavior are also induced by redistricting. The empirical results show that legislators subject to redistricting change their voting behavior to accord better with altered constituency preferences.
Outcome of elderly patients after failure to hypomethylating agents given as frontline therapy for acute myeloid leukemia: Single institution experience*

Outcomes of acute myeloid leukemia (AML) in elderly patients unfit for intensive chemotherapy is challenging. Hypomethylating agents (HMAs) can be effective in these patients but responses are usually short‐lived. The majority of patients will either have stable disease or progress through therapy. We hereby describe the outcome of these patients at our institution after they fail HMAs. The data on 56 AML patients at Mayo Clinic, Rochester were reviewed. Patients were considered for our study if they received HMA as frontline therapy for their AML. Out of 56 patients, 15 (27%) patients received azacitidine (AZA) and 41 (73%) received decitabine. Complete remission was found in 10 (18%), with overall response of 28% and median response duration of 10 months. Thirteen (81%) out of 16 responders relapsed. Therefore 53 patients were included in the primary or secondary failure analysis with a median overall survival (OS) of 2 months after the date of failure. Out of 53 patients, 12 (23%) received subsequent treatments. None of the 12 patients who got first salvage therapy achieved remission. Five out of the 12 patients received second salvage therapy, 2 (40%) of which achieved CR. Median OS for patients who received subsequent salvage therapies was better than those who did not receive any subsequent therapy after failing HMA (9.5 vs. 2 months, P = .0009). Outcome for patients who have primary or secondary failure is very poor. Our study provides important historical data for future novel therapies, which are sorely needed for these patients.
Dopaminergic modulation of adenylate cyclase stimulation by vasoactive intestinal peptide in anterior pituitary.

The activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6. 1.1] by vasoactive intestinal peptide (VIP) was used as a model to investigate the molecular mechanisms triggered by the occupancy of dopamine recognition sites in rat anterior pituitary. Dopamine failed to change the basal enzyme activity, but it inhibited the stimulation of adenylate cyclase elicited by VIP. Apomorphine, 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, and 2-bromo-alpha-ergocryptine mimicked the effect of dopamine, whereas (-)-sulpiride and and classical neuroleptics antagonized it. Dopamine failed to modulate the activation of pituitary adenylate cyclase by prostaglandin E1, which does not increase prolactin secretion. From these results we infer that stimulation of D-2 (dopamine) receptors may affect pituitary secretion by inhibiting the activation of anterior pituitary adenylate cyclase by VIP or other secretagogues.
Identifying Culture-Specifics in the Content and Structure of Values

Using data from 88 samples from 40 countries, the authors reevaluate the propositions of a recent values theory and provide criteria for identifying what is culture-specific in value meanings and structure. They confirm the widespread presence of 10 value types, arrayed on a motivational continuum, and organized on virtually universal, orthogonal dimensions: Openness to Change versus Conservation and Self-Transcendence versus Self-Enhancement. Forty-four values demonstrate high cross-cultural consistency of meaning. In the average sample, about 16% of single values diverge from their proto-typical value types, and one pair of motivationally close value types is intermixed. Test-retest and randomly split sample analyses reveal that some two thirds of deviations represent unreliable measurement and one third represent culture-specific characteristics. Ways to identify and interpret the latter are presented.