Miracle-dz/UniFAR-FTUs huggingface dataset:
Successful Transitions to the Olympic Training Center, Colorado Springs: A Mixed-Method Exploration with Six Resident-Athletes

Researchers examine athletic career transition in a quest to optimize performance achievements and the well-being of athletes (Alfermann & Stambulova, 2007). This exploratory study examined the internal and external resources that contributed to a successful transition to the Olympic Training Center in Colorado Springs (CSOTC). Six athletes (four males and two females; M age = 23.5 when entering CSOTC) participated in individual interviews (dominant feature of the mixed-method design) and responded to a battery of psychometric tests (less dominant feature). The composite (qualitative and quantitative) findings included three meta-themes: optimism, sport-life balance, and transition- and performance-enhancing resourcefulness.
Is rheumatoid arthritis disappearing?

During the past decades a number of studies have examined the incidence of rheumatoid arthritis (RA) in different geographical settings and at different times. Some studies from the 1970s and 1980s reported a higher incidence of RA than seen during recent years, where reported incidence numbers seems to have flattened out at a lower level. Besides a real time dependent decline of RA incidence, changing methodology in classification may be an equally important explanation. Today we may assume that annually 25–50 people from a population of 100 000 will develop typical RA.
The Critical Traditionalism of Ashis Nandy

This article offers an analysis of the construction and deployment of the ideas of ‘the West’ and ‘tradition’ in the social commentary of Ashis Nandy. It argues that Nandy's ‘critical’ defence of tradition is framed and animated by occidentalism and renders tradition into a paradoxical space of redemption and innocence. The first part of the paper shows that Nandy's nativist narratives of loss and his suspicion of political ideologies place him both in and against post-colonial cultural politics. The second section examines and illustrates the mutually defining nature of occidentalism and traditionalism. It is shown that Nandy's stereotypes of authentic Indian culture undermine the critical capabilities of his ‘critical traditionalism’. Part three explores Nandy's dilemmas further by reference to his attempts to align tradition with reflexivity.
Product Architectures and Sourcing Decisions

The relationship between product architecture (PA) and a firm’s make or buy (M-B) sourcing decision has been a topic of interest over the past several years. However, the interplay between PA and a firm’s M-B decision and its impact on performance is still underexplored. This study draws on transaction cost economics and the knowledge-based view within the framework of the PA and sourcing strategy literature to develop a causal model concerning the relationship between PA and the M-B sourcing decision and its implication for technological and financial performance via an investigation of the bicycle freewheel and derailleur markets from 1980 to 1995. The study readily provides theoretical reasoning as to why firms should choose an M-B sourcing strategy in the context of integral-modular PAs. It also suggests the need for further theoretical and empirical investigation of the relationships between PA type and the M-B choice and of the resulting impact of the sourcing decision on performance.
Cartilage abnormalities associated with defects of chondrocytic primary cilia in Bardet‐Biedl syndrome mutant mice

Primary cilia are found on nearly every mammalian cell, including osteocytes, fibroblasts, and chondrocytes. However, the functions of primary cilia have not been extensively studied in these cells, particularly chondrocytes. Interestingly, defects in the primary cilium result in skeletal defects such as polydactyly in Bardet‐Biedl syndrome (BBS), a ciliary disorder that also results in obesity, retinopathy, and cognitive impairments. Wild‐type mice and mutant mice of the ciliary proteins Bbs1, Bbs2, and Bbs6 were evaluated with respect to histological and biochemical differences in chondrocytes from articular cartilage and xiphoid processes. Using immunofluorescence microscopy, chondrocytic cilia were visualized from the load‐bearing joints and non‐load‐bearing xiphoid processes. Significant differences in ciliary morphology were not identified between mutant and wild‐type mice. However, after expanding chondrocytes in cell culture and implanting them in solid agarose matrix, it was seen that the fraction of ciliated cells in cultures from mutant mice was significantly lower than in the wild‐type cultures (p < 0.05). In addition, in Safranin‐O‐stained whole joint sections, Bbs mutant mice had significantly lower articular joint thickness (p < 0.05) and lower proteoglycan content saturation (p < 0.05) than wild‐type mice. Moreover, there were statistically significant differences of cell distribution between Bbs mutant and wild‐type mice (p < 0.05), indicating that mutant articular cartilage had changes consistent with early signs of osteoarthritis. These data indicate that Bbs genes and their functions in the chondrocytic primary cilium are important for normal articular cartilage maintenance. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27: 1093–1099, 2009
Lillian McMurry of Trumpet Records: Integrity and Authenticity in the Charismatic, Constructive Narcissist Leader

Although the emerging construct of authentic leadership has received considerable attention recently, there are still diverse and competing theoretical perspectives. Common with nascent theory, many have suggested that researchers attempt to craft expanded and more nuanced conceptions of current and potential components, antecedents, and outcomes associated with the conduct and attribution of leader authenticity. Although such theoretical advancement is essential to the maturation of the paradigm, management historians recognize the important role the historical record can play in the progression of contemporary frameworks. During archival research of the business proceedings of Trumpet Records, a 1950s independent record label, we encountered the compelling story of an entrepreneurial leader whose extraordinary integrity and authenticity appeared inconsistent with certain aspects of the principal authentic leadership definitions beginning to converge in the literature. Accordingly, we examined the life and writings of Lillian McMurry, the founder of Trumpet Records, to propose a framework by which leader integrity initiates the conduct and attribution of authentic leadership to transcend charismatic and narcissistic tendencies and diminish the abuse of symbolic status.
Depressive Symptoms among US Military Spouses during Deployment

Using the Broaden-and-Build Theory of Positive Emotions, the relationships among stress, positivity, and depressive symptoms were examined in a sample of military spouses during deployment (N = 367). Over one-third of the spouses reported moderately severe levels of depressive symptoms. After controlling for demographic and deployment variables, stress had a positive association with depressive symptoms (β = .59, p < .001), while positivity had a negative association (β = −.39, p < .001). Positivity was also found to play a moderating role on the relationship between stress and depressive symptoms (β = −.29, p < .001). Spouses with lower positivity reported more depressive symptoms at both low and high levels of stress compared to those with higher positivity. The final model, including both direct and moderating variables, accounted for 69 percent of the total variance in depressive symptoms. Practical implications are discussed in terms of the importance of developing positivity in military spouses.
The Syrian Crisis in the News

Drawing on scholarship on framing, sourcing, and war journalism, this content analysis explores how The New York Times and The Washington Post covered the international reaction to Syria's use of chemical weapons against its own citizens in August 2013. The analysis found that stories in the month following the event focused primarily on diplomacy efforts and stopped paying attention to the ongoing civil war. Despite that, conflict framing was still dominant. The stories were generally thematic and richly sourced. The analysis lends support to the literature on the relationship between sourcing and framing as well as to the indexing hypothesis.
Developments in treatments for amyotrophic lateral sclerosis via intracerebroventricular or intrathecal delivery

Introduction: Amyotrophic lateral scleroses (ALS) are neurodegenerative disorders primarily affecting the motor system. These incurable disorders are relentlessly progressive and typically limit survival to 2 – 5 years after disease onset. An improved knowledge about disease-causing genes, disease proteins and pathways has revealed considerable heterogeneity in ALS. Novel targeted therapies are being developed, but getting these beyond the BBB remains a challenge. Areas covered: The authors review the intracerebroventricular and intrathecal delivery of drugs for the treatment of ALS in preclinical and clinical studies. Expert opinion: Lack of BBB permeability should not hold back the development of promising treatments for ALS, as the available evidence suggest that direct intrathecal or intracerebroventricular administration of drug is a feasible delivery route in patients with ALS.
CellLineNavigator: a workbench for cancer cell line analysis

The CellLineNavigator database, freely available at http://www.medicalgenomics. org/celllinenavigator, is a web-based workbench for large scale comparisons of a large collection of diverse cell lines. It aims to support experimental design in the fields of genomics, systems biology and translational biomedical research. Currently, this compendium holds genome wide expression profiles of 317 different cancer cell lines, categorized into 57 different pathological states and 28 individual tissues. To enlarge the scope of CellLineNavigator, the database was furthermore closely linked to commonly used bioinformatics databases and knowledge repositories. To ensure easy data access and search ability, a simple data and an intuitive querying interface were implemented. It allows the user to explore and filter gene expression, focusing on pathological or physiological conditions. For a more complex search, the advanced query interface may be used to query for (i) differentially expressed genes; (ii) pathological or physiological conditions; or (iii) gene names or functional attributes, such as Kyoto Encyclopaedia of Genes and Genomes pathway maps. These queries may also be combined. Finally, CellLineNavigator allows additional advanced analysis of differentially regulated genes by a direct link to the Database for Annotation, Visualization and Integrated Discovery (DAVID) Bioinformatics Resources.
When Predictions Fail: The Case of Unexpected Pathways Toward High School Dropout

This study examines childhood variables that tend to deflect life-course trajectories away from finishing high school. We examined unexpectedly graduating in the presence of three empirical risk factors (having a mother that did not finish high school, being from a single-parent family in early childhood, and having repeated a grade in primary school) and unexpectedly not graduating in the absence these same factors (low risk). The comparison groups comprised individuals who expectedly did not graduate (first case) and expectedly graduated (second case). We found that having experienced all three factors practically guaranteed not finishing high school, thus defining a crystal clear target group for policy. Without screening, intervention, and follow-up, individuals facing such cumulative risk are most unlikely to graduate. We also found a group of males and females that did not finish high school despite not having these three risk factors. These missed estimates become nontrivial once they are translated into a population-level statistic of lost human capital investments. Specific family and individual factors helped explain the unexpected life course toward not finishing high school, especially for low-risk males and females. Our results suggest policies that support childhood screening for attention-related difficulties and helping parents better understand supervision during adolescence.
Fast Bound Pool Fraction Mapping Using Stimulated Echoes

Magnetization transfer imaging advanced to an indispensible tool for investigating white matter changes. Quantitative magnetization transfer imaging methods allow the determination of the bound pool fraction (BPF), which is thought to be directly linked to myelin integrity. Long acquisition times and high specific absorption rates are still inhibiting broad in vivo utilization of currently available BPF mapping techniques. Herewith, a stimulated echoes amplitude modulation‐based, single‐shot echo planar imaging technique for BPF and T1 quantification is presented at 3T. It allows whole brain mapping in 10–15 min and is low in specific absorption rates. The method was validated with different concentrations of bovine serum albumin (BSA) phantoms. Intra‐ and inter‐subject variability was assessed in vivo. Phantom measurements verified linearity between bovine serum albumin concentrations and measured BPF, which was independent of T1 variations. T1 values in the phantoms correlated well with values provided by standard T1 mapping methods. Intrasubject variability was minimal and mean regional BPFs of 10 volunteers (e.g., left frontal white matter = 0.135 ± 0.003, right frontal white matter = 0.129 ± 0.006) were in line with previously published data. Assessment of interhemispheric BPF differences revealed significantly higher BPF for the left brain hemisphere. To sum up, these results suggest the proposed method useful for cross‐sectional and longitudinal studies of white matter changes in the human brain. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.
Structural Heterogeneity and Quantitative FRET Efficiency Distributions of Polyprolines through a Hybrid Atomistic Simulation and Monte Carlo Approach

Förster Resonance Energy Transfer (FRET) experiments probe molecular distances via distance dependent energy transfer from an excited donor dye to an acceptor dye. Single molecule experiments not only probe average distances, but also distance distributions or even fluctuations, and thus provide a powerful tool to study biomolecular structure and dynamics. However, the measured energy transfer efficiency depends not only on the distance between the dyes, but also on their mutual orientation, which is typically inaccessible to experiments. Thus, assumptions on the orientation distributions and averages are usually made, limiting the accuracy of the distance distributions extracted from FRET experiments. Here, we demonstrate that by combining single molecule FRET experiments with the mutual dye orientation statistics obtained from Molecular Dynamics (MD) simulations, improved estimates of distances and distributions are obtained. From the simulated time-dependent mutual orientations, FRET efficiencies are calculated and the full statistics of individual photon absorption, energy transfer, and photon emission events is obtained from subsequent Monte Carlo (MC) simulations of the FRET kinetics. All recorded emission events are collected to bursts from which efficiency distributions are calculated in close resemblance to the actual FRET experiment, taking shot noise fully into account. Using polyproline chains with attached Alexa 488 and Alexa 594 dyes as a test system, we demonstrate the feasibility of this approach by direct comparison to experimental data. We identified cis-isomers and different static local environments as sources of the experimentally observed heterogeneity. Reconstructions of distance distributions from experimental data at different levels of theory demonstrate how the respective underlying assumptions and approximations affect the obtained accuracy. Our results show that dye fluctuations obtained from MD simulations, combined with MC single photon kinetics, provide a versatile tool to improve the accuracy of distance distributions that can be extracted from measured single molecule FRET efficiencies.
Zoonotic Hepatitis E Virus: An Ignored Risk for Public Health

Hepatitis E virus (HEV) is a quasi-enveloped, single-stranded positive-sense RNA virus. HEV belongs to the family Hepeviridae, a family comprised of highly diverse viruses originating from various species. Since confirmation of HEV’s zoonosis, HEV-induced hepatitis has been a public health concern both for developing and developed countries. Meanwhile, the demonstration of a broad host range for zoonotic HEV suggests the existence of a variety of transmission routes that could lead to human infection. Moreover, anti-HEV antibody serosurveillance worldwide demonstrates a higher than expected HEV prevalence rate that conflicts with the rarity and sporadic nature of reported acute hepatitis E cases. In recent years, chronic HEV infection, HEV-related acute hepatic failure, and extrahepatic manifestations caused by HEV infection have been frequently reported. These observations suggest a significant underestimation of the number and complexity of transmission routes previously predicted to cause HEV-related disease, with special emphasis on zoonotic HEV as a public health concern. Significant research has revealed details regarding the virology and infectivity of zoonotic HEV in both humans and animals. In this review, the discovery of HEV zoonosis, recent progress in our understanding of the zoonotic HEV host range, and classification of diverse HEV or HEV-like isolates from various hosts are reviewed in a historic context. Ultimately, this review focuses on current understanding of viral pathogenesis and cross-species transmission of zoonotic HEV. Moreover, host factors and viral determinants influencing HEV host tropism are discussed to provide new insights into HEV transmission and prevalence mechanisms.
Antecedents and Consequences of the Perceived Threat of Sexual Communication: A Test of the Relational Turbulence Model

This study applied the relational turbulence model to understand the dynamics of sexual communication between romantic partners. We conducted a cross-sectional, dyadic study in which both partners from 85 sexually active couples completed questionnaires about their romantic characteristics, sexual communication, and perceptions of their sexual relationship. Results showed that (a) relational uncertainty and interference from partners were positively associated with the perceived threat of sexual communication; (b) perceived threat of sexual communication was positively associated with both sexual topic avoidance and indirect communication about sexual intimacy; (c) both sexual topic avoidance and indirect sexual communication were negatively associated with sexual satisfaction for females, whereas only sexual topic avoidance was negatively associated with sexual satisfaction for males; and (d) for males only, there was a direct negative association between the perceived threat of sexual communication and sexual satisfaction. Our findings highlight the implications of relational turbulence for predicting cognitive and communicative reactions to sexual intimacy.
Spatial Visualization in Physics Problem Solving

Three studies were conducted to examine the relation of spatial visualization to solving kinematics problems that involved either predicting the two-dimensional motion of an object, translating from one frame of reference to another, or interpreting kinematics graphs. In Study 1, 60 physics-naíve students were administered kinematics problems and spatial visualization ability tests. In Study 2, 17 (8 high- and 9 low-spatial ability) additional students completed think-aloud protocols while they solved the kinematics problems. In Study 3, the eye movements of fifteen (9 high- and 6 low-spatial ability) students were recorded while the students solved kinematics problems. In contrast to high-spatial students, most low-spatial students did not combine two motion vectors, were unable to switch frames of reference, and tended to interpret graphs literally. The results of the study suggest an important relationship between spatial visualization ability and solving kinematics problems with multiple spatial parameters.
Indirect Service Delivery Through Consultation

Consultation as a form of indirect service delivery is defined and its theoretical bases are discussed. Literature drawn from school psychology, counseling psychology, organizational theory, and special education is reviewed as regards three types of variables: input, process, and outcome. Barriers to the effective practice of consultation and implications for early intervention programming are discussed. Effective indirect service delivery through consultation requires specialized training for all staff involved and may increase opportunities for children with disabilities to receive early intervention in integrated settings.
The `New' Corporate Habitus in Adventure Racing

This article explores the overrepresentation of management-level corporate participants in Discovery Channel Eco-Challenge (DCEC) as a suggestion of the emergence of a new class — or social group — habitus common to both `new' corporate culture and the adventure racing (AR) field. The current analysis, which examines the parallels between conceptualizations, perceptions and judgements of practice embedded in AR and `new' corporate discourses, has two aims: first, to uncover the practice-generating principle(s) (habitus) in the AR field; second, to explore the relationship between the AR and `new' corporate habitus through AR's purported benefit of `transferability'. Our qualitative analysis is based on participant observation and on 37 semi-structured interviews with AR participants.
Effects of Framing on Evaluation of Comparable and Noncomparable Alternatives by Expert and Novice Consumers

The study finds that framing, i.e., priming different decision criteria, influences evaluation outcomes for both expert and novice consumers when the alternatives are noncomparable and influences evaluation outcomes for novices when the alternatives are comparable. The ready availability of a decision criterion, as opposed to the lack of one, also alters consumers' cognitive responses for noncomparable sets to make these responses appear more like cognitive responses typical of comparable sets. One fundamental distinction between sets of noncomparable and comparable alternatives may be the ready availability of decision criteria versus the need to construct them, rather than any inherent differences in category types.