Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Effect of Parathyroid Hormone (1–34) on Implant Fixation

Intermittent systemic administration of parathyroid hormone increases bone formation by stimulating osteoblastic activity. The current study determined how parathyroid hormone (1–34) administration influences the bony fixation of stainless steel screws with time. A screw was implanted in the left tibia and a metal rod was implanted in the right tibia in 30 adult male rats that then were injected three times a week with human parathyroid hormone (1–34) at 60 μg/kg/injection (n = 15) or saline (n = 15). The animals were euthanized after 1, 2, or 4 weeks of treatment. Eight additional rats received only the screw and were euthanized immediately after implantation. No significant effects of parathyroid hormone on body weight change or ash weight of the femurs were seen. The degree of fixation was assessed by measuring pullout strength of the screws. The mean pullout strength immediately after implantation was 12 N. The pullout strength of the group injected with saline was 33 N after 1 week, 23 N after 2 weeks, and 41 N after 4 weeks. The pullout strength of the group injected with parathyroid hormone increased to 43 N after 1 week, 58 N after 2 weeks, and 100 N after 4 weeks. The increase at 2 and 4 weeks was statistically significant. Strength reflects the mechanical properties of the bone within the screw threads. The contralateral tibia with its metal rod was used for blinded histologic assessment. Parathyroid hormone increased the fraction of the metal surface having contract with bone without an intervening soft tissue layer from 45% to 69% after 1 week. The current results suggest that intermittent parathyroid hormone treatment can enhance early implant fixation by enhancing the density of the surrounding bone and by increasing the implant bone contact.
Estimating O–D travel time matrix by Google Maps API: implementation, advantages, and implications

Many spatial analysis tasks call for the use of travel time between multiple origins and destinations, that is, O–D travel time matrix. Commercial geographical information systems (GIS) software requires the input of a well-defined road network dataset and significant efforts in implementing the task. However, road network data are often outdated, miss critical road condition details, or are expensive to acquire; and skillful usage of related software is a major obstacle for researchers without advanced training in GIS. This research develops a desktop tool for implementing the task by calling the Google Maps Application Programming Interface (API). By doing so, we are able to tap into the dynamically updated transportation network data and the routing rules maintained by Google and obtain a reliable estimate of O–D travel time matrix. The results are compared with those computed by the ArcGIS Network Analyst module to demonstrate its advantages. A case study in accessibility analysis is presented to illustrate the implications.
Sweet's syndrome in an Australian hospital: A retrospective analysis

A retrospective analysis was performed of patients meeting the clinicopathological diagnosis of Sweet's syndrome identified over a 10‐year period, in a metropolitan hospital. Nine patients met the inclusion criteria. Two patients had preceding streptococcal infection, two had associated inflammatory bowel disease, two had idiopathic Sweet's syndrome, and three had an underlying malignancy, one of whom was receiving granulocyte colony‐stimulating factor. Although only three patients were found to have an elevated white cell count, erythrocyte sedimentation rate or C‐reactive protein was elevated in all patients when measured. There was a wide spectrum of clinical presentations, with variations in lesion distribution and the presence/absence of systemic symptoms such as fever and arthralgia. Fever was observed in two‐thirds of cases. Seven patients responded to oral corticosteroids, while one patient cleared spontaneously and one patient was lost to follow up. As erythrocyte sedimentation rate or C‐reactive protein was elevated in all cases when measured, it may be a useful diagnostic tool.
The Conditioning Effects of Race and Gender on the Juvenile Court Outcomes of Delinquent and “Neglected” Types of Offenders

Drawing upon concepts from prior research that emphasize race and gender stereotyping, the present research compares how delinquent and “neglected” types of offenses (i.e. status offenses, probation violations, youth charged with contempt) are treated across three juvenile court outcomes. Beyond how offense type may directly impact case outcomes, we also investigated whether race and gender influenced juvenile justice processing within each offense type. Using data from two Mid-Atlantic States, results indicated that type of offense, race, and gender resulted in both severe and lenient case outcomes depending on the stage examined. By including different types of offenses that represent a significant percentage of youth that have been relatively neglected in prior research, the current study provides greater insight into the contexts of race and gender disparities in juvenile justice decision-making. The implications of the findings and directions for future research are also discussed.
System architecture and key technologies for 5G heterogeneous cloud radio access networks

Compared with fourth generation cellular systems, fifth generation wireless communication systems are anticipated to provide spectral and energy efficiency growth by a factor of at least 10, and the area throughput growth by a factor of at least 25. To achieve these goals, a H-CRAN is presented in this article as the advanced wireless access network paradigm, where cloud computing is used to fulfill the centralized large-scale cooperative processing for suppressing co-channel interferences. The state-of-the-art research achievements in the areas of system architecture and key technologies for H-CRANs are surveyed. Particularly, Node C as a new communication entity is defined to converge the existing ancestral base stations and act as the base band unit pool to manage all accessed remote radio heads. Also, the software-defined H-CRAN system architecture is presented to be compatible with software-defined networks. The principles, performance gains, and open issues of key technologies, including adaptive large-scale cooperative spatial signal processing, cooperative radio resource management, network function virtualization, and self-organization, are summarized. The major challenges in terms of fronthaul constrained resource allocation optimization and energy harvesting that may affect the promotion of H-CRANs are discussed as well.
A conversational virtual human as autonomous assistant for elderly and cognitively impaired users? Social acceptability and design considerations

In this paper we explore how a conversational virtual human could be designed to be deployed as a socially acceptable autonomous assistive system for elderly and cognitively impaired users. In particular, we focus on a system’s functionality in helping to maintain a well-structured daily life. We present initial findings from two types of studies: (1) Conducting interviews and focus groups considering users' attitudes and design considerations for assistance in maintaining well-structured daily routines and (2) analyzing interaction between the system and its users' while entering data into a calendar application. Analysis has revealed a set of design considerations for developing a socially acceptable system. Microanalytic investigation of one user’s concrete interaction with a Wizard-of-Oz version of the system has shown that a cognitively impaired person is able – by himself and only through interacting with the system – to gain insights into the system’s possibilities and limits and to mistrust the system’s competencies once the system initiates a repair sequence.
Non-adherence to telemedicine interventions for drug users: systematic review

OBJECTIVE To estimate rates of non-adherence to telemedicine strategies aimed at treating drug addiction. METHODS A systematic review was conducted of randomized controlled trials investigating different telemedicine treatment methods for drug addiction. The following databases were consulted between May 18, 2012 and June 21, 2012: PubMed, PsycINFO, SciELO, Wiley (The Cochrane Library), Embase, Clinical trials and Google Scholar. The Grading of Recommendations Assessment, Development and Evaluation was used to evaluate the quality of the studies. The criteria evaluated were: appropriate sequence of data generation, allocation concealment, blinding, description of losses and exclusions and analysis by intention to treat. There were 274 studies selected, of which 20 were analyzed. RESULTS Non-adherence rates varied between 15.0% and 70.0%. The interventions evaluated were of at least three months duration and, although they all used telemedicine as support, treatment methods differed. Regarding the quality of the studies, the values also varied from very poor to high quality. High quality studies showed better adherence rates, as did those using more than one technique of intervention and a limited treatment time. Mono-user studies showed better adherence rates than poly-user studies. CONCLUSIONS Rates of non-adherence to treatment involving telemedicine on the part of users of psycho-active substances differed considerably, depending on the country, the intervention method, follow-up time and substances used. Using more than one technique of intervention, short duration of treatment and the type of substance used by patients appear to facilitate adherence.
Exploring psychosocial well-being in a group of marginalised African youth

130 Psychosocial Well-being 132 Psychosocial Well-being Amongst Marginalised Youth 132 Coping and Self-efficacy as Components of Psychosocial Well-being of Youth 134 Research Methodology 138 Research design 138 Research aims and hypotheses 138 Participants 139 Table 1: Biographical Characteristics of the Participants (N = 794) 141 Data collection 142 Measuring instruments 142 Research Procedure 144 Data Analysis 145 Ethical Considerations 145 Results 146 Table 2: Descriptive Statistics and Reliability Indices (N=794) 147 Figure 1: Prevalence of high, moderate and low scorers (N=794) 148 Table 3: Correlations for scales and sub scales with N=794 participants 149 The measurement model 150 Table 4: Fit Statistics of Competing Measurement Models 151 The structural model 152 Figure 2: Structural equation model with best statistical fit of data 152 Table 5: Difference Testing for Competing Structural Models 153 Discussion 156 Limitations and Recommendations 157 References 159
Chronicling the Development of the Human Relations Perspective in Organizational Management

Launched from an organizational communication perspective, this article chronicles the four Hawthorne studies that led to the development of the human relations theory. The article shows how the Hawthorne studies led to the birth of the human relations management approach. The main tenets of human relations theory are discussed, as are its limitations. The article looks at both empirical and ideological limitations to the theory. The article ends by looking into the efforts to address these limitations, namely the evolution of human relations theory into a human resource approach. human relations theory, Hawthorne Studies, human resource approach, organizational communication
Is the Iceberg Melting Less Quickly? International Trade Costs after World War Ii

International trade costs are of vital importance because they determine trade patterns and therefore economic performance. This paper develops a new micro-founded measure of international trade costs. It is based on a multi-country general equilibrium model of trade that incorporates bilateral "ice-berg" trade costs. The model results in a gravity equation from which the implied trade costs can be easily computed. The trade cost measure is intuitive, takes multilateral resistance into account and yields empirical results that are economically sensible. It is found that during the post-WorldWar II period trade costs have declined markedly. The dispersion of trade costs across countries can best be explained by geographical and historical factors like distance and colonial linkages but also by tariffs and free trade agreements
Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte

The unidirectional movements of the microtubule-associated motors, dyneins, and kinesins, provide an important mechanism for the positioning of cellular organelles and molecules. An intriguing possibility is that this mechanism may underlie the directed transport and asymmetric positioning of morphogens that influence the development of multicellular embryos. In this report, we characterize the Drosophila gene, Dhc64C, that encodes a cytoplasmic dynein heavy chain polypeptide. The primary structure of the Drosophila cytoplasmic dynein heavy chain polypeptide has been determined by the isolation and sequence analysis of overlapping cDNA clones. Drosophila cytoplasmic dynein is highly similar in sequence and structure to cytoplasmic dynein isoforms reported for other organisms. The Dhc64C dynein transcript is differentially expressed during development with the highest levels being detected in the ovaries of adult females. Within the developing egg chambers of the ovary, the dynein gene is predominantly transcribed in the nurse cell complex. In contrast, the encoded dynein motor protein displays a striking accumulation in the single cell that will develop as the oocyte. The temporal and spatial pattern of dynein accumulation in the oocyte is remarkably similar to that of several maternal effect gene products that are essential for oocyte differentiation and axis specification. This distribution and its disruption by specific maternal effect mutations lends support to recent models suggesting that microtubule motors participate in the transport of these morphogens from the nurse cell cytoplasm to the oocyte.
Deep Manifold Learning of Symmetric Positive Definite Matrices with Application to Face Recognition

In this paper, we aim to construct a deep neural network which embeds high dimensional symmetric positive definite (SPD) matrices into a more discriminative low dimensional SPD manifold. To this end, we develop two types of basic layers: a 2D fully connected layer which reduces the dimensionality of the SPD matrices, and a symmetrically clean layer which achieves non-linear mapping. Specifically, we extend the classical fully connected layer such that it is suitable for SPD matrices, and we further show that SPD matrices with symmetric pair elements setting zero operations are still symmetric positive definite. Finally, we complete the construction of the deep neural network for SPD manifold learning by stacking the two layers. Experiments on several face datasets demonstrate the effectiveness of the proposed method.
Molecular phylogenetics of Boulengerula (Amphibia: Gymnophiona: Caeciliidae) and implications for taxonomy, biogeography and conservation

1Department of Environmental Sciences, Institute of Biogeography, University of Basel, Switzerland 2Department of Zoology, Natural History Museum, London, UK 3School of Biological and Chemical Sciences, Queen Mary University of London, UK 4Wellcome Trust Sanger Institute, Cambridge, UK 5Applied Biodiversity Research Division, South African National Biodiversity Institute, Cape Town, South Africa 6Department of Biodiversity and Conservation Biology, University of the Western Cape, Bellville, South Africa 7Sezione di Zoologia dei Vertebrati, Museo Tridentino di Scienze Naturali, Trento, Italy 8Department of Zoology and Marine Biology, University of Dar es Salaam, Tanzania 9Institut fur Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, Universitat Jena, Germany
Characterization of Novel β-Galactosidase Activity That Contributes to Glycoprotein Degradation and Virulence in Streptococcus pneumoniae

ABSTRACT The pneumococcus obtains its energy from the metabolism of host glycosides. Therefore, efficient degradation of host glycoproteins is integral to pneumococcal virulence. In search of novel pneumococcal glycosidases, we characterized the Streptococcus pneumoniae strain D39 protein encoded by SPD_0065 and found that this gene encodes a β-galactosidase. The SPD_0065 recombinant protein released galactose from desialylated fetuin, which was used here as a model of glycoproteins found in vivo. A pneumococcal mutant with a mutation in SPD_0065 showed diminished β-galactosidase activity, exhibited an extended lag period in mucin-containing defined medium, and cleaved significantly less galactose than the parental strain during growth on mucin. As pneumococcal β-galactosidase activity had been previously attributed solely to SPD_0562 (bgaA), we evaluated the contribution of SPD_0065 and SPD_0562 to total β-galactosidase activity. Mutation of either gene significantly reduced enzymatic activity, but β-galactosidase activity in the double mutant, although significantly less than that in either of the single mutants, was not completely abolished. The expression of SPD_0065 in S. pneumoniae grown in mucin-containing medium or tissues harvested from infected animals was significantly upregulated compared to that in pneumococci from glucose-containing medium. The SPD_0065 mutant strain was found to be attenuated in virulence in a manner specific to the host tissue.
Protesting the Paradigm

This study assesses the scope and applicability of the “protest paradigm” in non-Western contexts by examining the news coverage of Brazilian, Chinese, and Indian protests in their domestic media. Two publications from each nation, one conservative and one progressive, are content analyzed for adherence to a series of marginalization devices that have often been used by the U.S. media to ridicule protest movements and portray them as violent. The Indian media emerge as the least likely to follow the protest paradigm, while Brazilian and Chinese media conform to it in moderate levels. Comparative analysis suggests the historical legitimacy of informal power negotiations in a political culture makes news media more willing to take protesters seriously and limits adherence to the protest paradigm. In contrast, a news organization’s ideological affiliation with the government of the day, rather than any ideology per se, makes it relatively more likely to conform to the protest paradigm. Marginalization devices such as circus, appearance, and eyewitness accounts are rarely used in any of these nations. But disparity of sources, (non)reference to protesters’ causes and violence, and violence blame appear to be abiding features of news coverage of protests everywhere.
First-principles elastic and thermal properties of TiO2: a phonon approach

Elastic and thermal properties of the TiO2 lattice in anatase and rutile phases were studied in the framework of density functional perturbation theory within the local density approximation (LDA) and generalized-gradient approximation (GGA). The full elastic constant tensors of the polymorphs were calculated by linear fits to the acoustic branches of the phonon band structure near the center of the first Brillouin zone in symmetry directions of the crystals. It was observed that the elastic constants within the GGA are in better agreement with experiment. In addition, the Born effective charges, dielectric tensor, heat capacity, mean sound velocity and Debye temperature were calculated. The heat capacity at room temperature and the Debye temperature within the LDA are in better agreement with the experimental results. Therefore, using the phonon band structure and the density of states, one can obtain the important mechanical and thermal properties of materials.
Yeast ribosomal protein L1 is required for the stability of newly synthesized 5S rRNA and the assembly of 60S ribosomal subunits

Ribosomal protein L1 from Saccharomyces cerevisiae binds 5S rRNA and can be released from intact 60S ribosomal subunits as an L1-5S ribonucleoprotein (RNP) particle. To understand the nature of the interaction between L1 and 5S rRNA and to assess the role of L1 in ribosome assembly and function, we cloned the RPL1 gene encoding L1. We have shown that RPL1 is an essential single-copy gene. A conditional null mutant in which the only copy of RPL1 is under control of the repressible GAL1 promoter was constructed. Depletion of L1 causes instability of newly synthesized 5S rRNA in vivo. Cells depleted of L1 no longer assemble 60S ribosomal subunits, indicating that L1 is required for assembly of stable 60S ribosomal subunits but not 40S ribosomal subunits. An L1-5S RNP particle not associated with ribosomal particles was detected by coimmunoprecipitation of L1 and 5S rRNA. This pool of L1-5S RNP remained stable even upon cessation of 60S ribosomal subunit assembly by depletion of another ribosomal protein, L16. Preliminary results suggest that transcription of RPL1 is not autogenously regulated by L1.
A Curriculum Designed to Decrease Barriers Related to Scholarly Writing by Staff Nurses

Demonstrating professional development outcomes, such as scholarly publication, is critical as nurse leaders guide organizations seeking recognition as centers of excellence. However, personal and situational barriers often prevent staff nurses from achieving scholarly publication. This project tested a workshop and mentoring approach to decrease publication barriers with staff nurses in 2 community hospitals. Self-efficacy principles guided the curriculum that resulted in a statistically significant improvement in staff nurse perception of successful scholarly publication endeavors.
Cognitive and behavioural characteristics in blind children with bilateral optic nerve hypoplasia.

AIM To describe cognitive and behavioural characteristics in a group of blind children with bilateral optic nerve hypoplasia (ONH). METHODS Data from records, parents, teachers, and repeated developmental assessments of 13 blind children with ONH born in 1988-1998 were analysed. All children had neuroimaging and/or hormonal evidence of midline malformations. They were all blind and able to communicate with speech. RESULTS Severe mood swings and temper tantrums were common, especially during the first years of life. Later in life, sluggish tempo, low frustration tolerance and a narrow range of interests were common. Autism had been diagnosed in 6/13 children, autistic-like condition (ALC) was found in another three. The behaviour of the remaining four children was not within the autism spectrum. Eight children had cognitive capacities within the normal or near-normal range; five had mental retardation. Autism/ALC was found in all cognitive subgroups. All children exhibited fluent speech and, of these, 12 had started to talk at the expected age, but had clear deficiencies in communicative ability. CONCLUSION These children had a common pattern of behavioural characteristics including autism spectrum disorders independent of intellectual capacities.
A Satellite RNA in Grapevine Fanleaf Virus Strain F13

SUMMARY The F 13 isolate of grapevine fanleaf virus (GFLV) differs from other isolates in that it induces severe symptoms on Chenopodium quinoa. We show here that its particles contain three RNA species with sizes, estimated by electrophoresis in agarose gels containing formaldehyde, of 6800 nucleotides (RNA 1), 3900 nucleotides (RNA2) and 1150 nucleotides (RNA3). The three RNA species are polyadenylated and probably have a genome-linked protein at their 5' end. RNA1 and RNA2 are known to be genomic RNAs. Evidence for the satellite nature of RNA3 came from Northern blot analysis with DNA probes. A probe originating from the 3' end region of RNA3 and corresponding to one-third of the molecule did not hybridize with either RNA1 or RNA2. Conversely 3'-terminal cDNA probes of RNA1 and RNA2 did not hybridize significantly to RNA3. Further proof of the satellite nature of RNA3 is that it depends on RNA1 and RNA2 for its multiplication in C. quinoa. RNA3 acts as mRNA in wheatgerm extract and directs the synthesis of a Mr 39000 protein.