Miracle-dz/UniFAR-FTUs huggingface dataset:
Estimation of Coastal Bathymetry Using RISAT-1 C-Band Microwave SAR Data

The study of swell wave refraction phenomena using synthetic aperture radar (SAR) data has been found to be very useful in estimating the underwater topography (seabed structure). Near-shore water regions generate a wide range of surface signatures due to rapidly changing underwater depths, which cause waves to refract and finally align parallel to the shoreline. Another significant change, which is observed as gravity waves approach the shoreline, is that their wavelength decreases and, as the energy of the wave is constant in the absence of dissipating forces, amplitude increases. The strong correlation between the change in wavelength and the underlying topography makes it possible to estimate the bathymetry from the measured wavelength. Normally available global bathymetric maps (e.g., ETOPO-1 bathymetry toposheets) are out of date and provide bathymetry at a very coarse resolution. In this letter, swell wave refraction phenomena using Radar Imaging Satellite C-band SAR data over coastal regions of Mumbai have been studied. The wave-tracing technique has been used to derive the wavelength of swell waves in near-shore regions and analyze the wavelength change in order to retrieve underwater topography using dispersion relation with swell wave properties. This SAR-based technique can be used to derive high-resolution bathymetric maps for near-coastal regions. Also, with this technique, temporal variations in the seabed can be measured to infer geological processes.
Measuring Personality in Wave I of the National Longitudinal Study of Adolescent Health

The researchers sought to develop a personality measure from items in Wave I of the National Longitudinal Study of Adolescent Health. The study found 13 items from three dimensions of personality (neuroticism, extroversion, and conscientiousness), and then examined the factor structure and internal consistency of each of the three dimensions. Within each personality dimension, the items showed a unidimensional factor structure and internal consistency estimates of the summed similar to scores from NEO Personality Inventories. The results can be used to further examine how child/adolescent personality is related to multiple mental and physical health outcomes in the Add Health database.
Protein expression in a transformed trabecular meshwork cell line: proteome analysis.

PURPOSE Characterization of the human trabecular meshwork (TM) proteome is hindered by the small mass of intact tissue and the slow growth of cultured cell strains. We have previously characterized a transformed TM cell strain (GTM3) that demonstrates many of the same protein expression and cell signaling systems of nontransformed cell strains. The aim of this study was to initiate a proteomic survey of GTM3 cells as the initial step toward characterization of the complete human TM proteome. METHODS GTM3 cells were cultured to confluence, harvested and solubilized in urea/Nonidet. The protein extract (600 mug) was focused in immobilized isoelectric focusing (IEF) strips, separated by 10% SDS PAGE, and visualized with colloidal Coomassie Blue. Spots of interest were excised, destained, and the contained proteins subjected to in-gel reduction, derivatization, and tryptic digestion. Tryptic peptides were extracted and analyzed by electrospray LC/MS/MS. Protein identification was made using the TurboSequest search algorithm and a recent version of the nonredundant human protein database downloaded from the National Center for Biotechnology Information (NCBI). RESULTS Eighty-seven (87) primary proteins and 93 variants of these proteins were identified. A website was created (TM proteome) that combines data such as graphic spot location within the gel, peptide sequence, apparent and calculated pI, apparent and calculated mass, percentage of coverage, and protein informatic website links. CONCLUSIONS Proteomic analysis of a transformed human TM cell line has been initiated combining preparative two-dimensional PAGE separation, LC/MS/MS analysis of major proteins, and bioinformatic cataloging of the data. Further investigation of data from the transformed cell strain will be used in a comparative fashion for spot identification of analytical proteomic gels of human TM tissue and cultured normal cells. These initial data will form the base from which the characterization of protein expression in the normal and glaucomatous TM can be accomplished.
Influence of personality on achievement of medical students

In this study second year medical students completed a battery of psychometric tests which measured both cognitive and non-cognitive personality traits. Personality profiles obtained have been compared with reported norms from some other published sources. The scores obtained from factor analyses of these tests were used as predictors of total achievement in cellular biology and physiology over two years. In agreement with reports by other authors we found that the most important trait contributing to achievement was introversion/extra-version with introversion correlating with high achievement particularly in multiple choice tests. Emotional maturity was also a major factor especially as a predictor of success in essay tests. General mental ability, verbal skills, and reading comprehension appeared as significant predictors of achievement, and these were apparently of comparable importance in both kinds of test. Students of foreign origin whose first language was other than English tended to perform better in essay than multiple choice tests but their overall performance was lower than would have been expected from their other personality traits including their verbal skills. On the other hand, students resident in college halls tended to have better overall performance than expected.
Maternal attachment style and depression associated with childbirth: preliminary results from a European and US cross-cultural study

Background Insecure attachment style relates to major depression in women, but its relationship to depression associated with childbirth is largely unknown. A new UK-designed measure, the Attachment Style Interview (ASI), has potential for cross-cultural use as a risk marker for maternal disorder. Aims To establish the reliability of the ASI across centres, its stability over a 9-month period, and its associations with social context and majoror minor depression. Method The ASI was used by nine centres antenatally on 204 women, with 174 followed up 6 months postnatally. Interrater reliability was tested and the ASI was repeated on a subset of 96 women. Affective disorder was assessed by means of the Structured Clinical Interview for DSM–IV. Results Satisfactory interrater reliability was achieved with relatively high stability rates at follow-up. Insecure attachment related to lower social class position and more negative social context. Specific associations of avoidant attachment style (angry–dismissive or withdrawn) with antenatal disorder, and anxious style (enmeshed or fearful) with postnatal disorder were found. Conclusions The ASI can be used reliably in European and US centres as a measure for risk associated with childbirth. Its use will contribute to theoretically underpinned preventive action for disorders associated with childbirth.
Neural correlates of recognition memory of social information in people with schizophrenia.

BACKGROUND Social dysfunction is a hallmark characteristic of schizophrenia. Part of it may stem from an inability to efficiently encode social information into memory and retrieve it later. This study focused on whether patients with schizophrenia show a memory boost for socially relevant information and engage the same neural network as controls when processing social stimuli that were previously encoded into memory. METHODS Patients with schizophrenia and healthy controls performed a social and nonsocial picture recognition memory task while being scanned. We calculated memory performance using d'. Our main analysis focused on brain activity associated with recognition memory of social and nonsocial pictures. RESULTS Our study included 28 patients with schizophrenia and 26 controls. Healthy controls demonstrated a memory boost for socially relevant information. In contrast, patients with schizophrenia failed to show enhanced recognition sensitivity for social pictures. At the neural level, patients did not engage the dorsomedial prefrontal cortex (DMPFC) as much as controls while recognizing social pictures. LIMITATIONS Our study did not include direct measures of self-referential processing. All but 3 patients were taking antipsychotic medications, which may have altered both the behavioural performance during the picture recognition memory task and brain activity. CONCLUSION Impaired social memory in patients with schizophrenia may be associated with altered DMPFC activity. A reduction of DMPFC activity may reflect less involvement of self-referential processes during memory retrieval. Our functional MRI results contribute to a better mapping of the neural disturbances associated with social memory impairment in patients with schizophrenia and may facilitate the development of innovative treatments, such as transcranial magnetic stimulation.
Expression characteristics of dual-promoter lentiviral vectors targeting retinal photoreceptors and Müller cells

Purpose Growing evidence suggests that successful treatment of many inherited photoreceptor diseases will require multi-protein therapies that not only correct the genetic defects linked to these diseases but also slow or halt the related degenerative phenotypes. To be effective, it is likely that therapeutic protein expression will need to be targeted to specific cell types. The purpose of this study was to develop dual-promoter lentiviral vectors that target expression of two proteins to retinal cones and rods, rods only, or Müller cells. Methods Dual-promoter lentivectors were constructed using the following promoters: Xenopus opsin promoter (XOPS)1.3, murine opsin promoter (MOPS), interphotoreceptor retinoid binding protein promoter (IRBP156), rhodopsin kinase (RK), neural retina leucine zipper (NRLL), vimentin (VIM), cluster differentiation (CD44), and glial fibrillary acidic protein (GFAP). Vectors were packaged and injected into the neural tubes of chicken embryos. The activities of the promoters alone, in duplicate, or when paired with a different promoter were analyzed in transduced, fully-developed retinas, using direct fluorescent and immunofluorescent microscopy. Results IRBP156, NRLL, and RK were active in cones and rods while XOPS1.3 was active only in rods. Of the glial promoters, only GFAP activity was restricted to Müller cells; both VIM and CD44 were active in Müller and neural cells. Dual-promoter vectors carrying IRBP156 and RK or XOPS1.3 and MOPS, in the order listed, exhibited robust expression of both reporter transgenes in cones and rods or rods only, respectively. Expression of the upstream transgene was much lower than the downstream transgene in dual-promoter vectors constructed using two copies of either RK or IRBP156. Analyses of the expression of a dual-promoter vector carrying CD44 and VIM in the order listed showed that the activity of the VIM promoter was more restricted to glial cells when paired with the CD44 promoter, while the activity of the CD44 promoter was inhibited to the extent that no CD44-driven reporter protein was detected in transduced cells. Conclusions We have identified two dual-promoter vectors, one that targets cones and rods and one that targets rods alone. Both vectors reliably express the two proteins encoded by the transgenes they carry. When two well matched promoters are not available, we found that it is possible to target expression of two proteins to single cells using dual-promoter vectors carrying two copies of the same promoter. These vectors should be useful in studies of retina when co-delivery of a reporter protein with an experimental protein is desired or when expression of two exogenous proteins in targeted cells is required.
Hardware assisted rate distortion optimization with embedded CABAC accelerator for the H.264 advanced video codec

This paper investigates the algorithmic complexity of rate distortion optimization and arithmetic coding in the new H.264 video coding standard and proposes a hardware accelerator to reduce it by more than an order of magnitude. The accelerator incorporates arithmetic coding and decoding engines and efficiently handles all the context information required by RDO and CABAC in H.264. The bit stream generated by the hardware is equivalent to that generated by the JM 9.4 reference implementation. The ISA of a controlling scalar 32-bit RISC CPU has been extended with custom RDO/CABAC instructions and the accelerator prototyped in a state-of-the-art FPGA technology.
Robust CRT-based watermarking technique for authentication of image and document

The advent of the Internet and the wide availability of computers, scanners, and printers make digital data acquisition, exchange, and transmission as simple tasks. However, making digital data accessible to others through networks also creates opportunities for malicious parties to make salable copies of copyrighted content without permission of the content owner. Digital watermarking techniques have been proposed as a solution to the problem of copyright protection of multimedia data in network environments. In this paper, we propose a novel CRT-based technique for digital watermarking and also look into increasing the capacity of watermark embedding in the host images. The proposed CRT-based technique, besides being computationally efficient, is also more resistant to different types of attacks together with a significant reduction in processing time and minimal distortion of the original image. Experimental results have shown that the performance of the new scheme is superior in both the quality of the extracted watermark and processing times in comparison to the two existing SVD-based watermarking techniques.
Transferring End-to-End Visuomotor Control from Simulation to Real World for a Multi-Stage Task

End-to-end control for robot manipulation and grasping is emerging as an attractive alternative to traditional pipelined approaches. However, end-to-end methods tend to either be slow to train, exhibit little or no generalisability, or lack the ability to accomplish long-horizon or multi-stage tasks. In this paper, we show how two simple techniques can lead to end-to-end (image to velocity) execution of a multi-stage task, which is analogous to a simple tidying routine, without having seen a single real image. This involves locating, reaching for, and grasping a cube, then locating a basket and dropping the cube inside. To achieve this, robot trajectories are computed in a simulator, to collect a series of control velocities which accomplish the task. Then, a CNN is trained to map observed images to velocities, using domain randomisation to enable generalisation to real world images. Results show that we are able to successfully accomplish the task in the real world with the ability to generalise to novel environments, including those with dynamic lighting conditions, distractor objects, and moving objects, including the basket itself. We believe our approach to be simple, highly scalable, and capable of learning long-horizon tasks that have until now not been shown with the state-of-the-art in end-to-end robot control.
Community-Based Thrombolytic Therapy of Acute Ischemic Stroke in Helsinki

Background and Purpose— Thrombolysis with alteplase is used in acute ischemic stroke within 3 hours after symptom onset in many stroke centers, but experience remains limited in Europe. Methods— Using eligibility and management criteria similar to those published by the American Heart Association, we treated 75 consecutive patients aged 21 to 83 years (mean age, 63.6 years; median Scandinavian Stroke Scale score, 32/58) with hemispheric infarction with alteplase in 1998–2001. Their neuroradiological findings (ischemic and hemorrhagic changes) and functional outcome at 3 months were evaluated. Results— Sixty-one percent of the patients had recovered functional independence (Barthel Index 95 to 100) at the 3-month follow-up. On the modified Rankin Scale (mRS), 37% (28/75) of patients had no or minimal symptoms (mRS 0 to 1), while 17% (13/75) remained dependent (mRS 4 to 5) and 5% (4/75) died. Cerebral parenchymal hematomas occurred in 8% (6/75) and hemorrhagic transformation in 8% (6/75) of the patients. Low initial diastolic blood pressure and administration of intravenous antihypertensive medication were associated with unfavorable outcome (mRS 3 to 6). Conclusions— We conclude that our management protocol for thrombolytic therapy is safe. These rates of functional outcome, case fatality, and hemorrhagic cerebral events compare favorably with those of other published series of stroke thrombolysis with similar time windows and management guidelines. Associations between blood pressure and its treatment during thrombolysis with functional outcome deserve further analysis.
Inhibition of Human Cytochrome P450 Isoforms by Nonnucleoside Reverse Transcriptase Inhibitors

The capacity of three clinically available nonnucleoside reverse transcriptase inhibitors (NNRTIs) to inhibit the activity of human cytochromes P450 (CYPs) was studied in vitro using human liver microsomes. Delavirdine, nevirapine, and efavirenz produced negligible inhibition of phenacetin O‐deethylation (CYP1A2) or dextromethorphan O‐demethylation (CYP2D6). Nevirapine did not inhibit hydroxylation of tolbutamide (CYP2C9) or S‐mephenytoin (CYP2C19), but these CYP isoforms were importantly inhibited by delavirdine and efavirenz. This indicates the likelihood of significantly impaired clearance of CYP2C substrate drugs (such as phenytoin, tolbutamide, and warfarin) upon initial exposure to these two NNRTIs. Delavirdine and efavirenz (but not nevirapine) also were strong inhibitors of CYP3A, consistent with clinical hazards of initial cotreatment with either of these drugs and substrates of CYP3A. The in vitro microsomal model provides relevant predictive data on probable drug interactions with NNRTIs when the mechanism is inhibition of CYP‐mediated drug biotransformation. However, the model does not incorporate interactions attributable to enzyme induction.
Structural fragility of blood vessels and peritoneum in calponin h1-deficient mice, resulting in an increase in hematogenous metastasis and peritoneal dissemination of malignant tumor cells.

We have observed weak expression of calponin h1, which stabilizes the actin filament system, in blood vessels within human malignant tumors. This observation suggested that because of a deficiency in stabilization by calponin h1, the structure of blood vessels in malignant tumors is fragile compared with blood vessels in normal tissues. We therefore generated calponin h1-deficient (CN(-/-)) mice to examine the effect of calponin h1 on the integrity of the barrier system in blood vessels against cancer metastasis. The CN(-/-) mice exhibited morphological fragility of the tissues, including the uterus and blood vessels. In particular, we frequently observed bleeding into the surrounding tissue from blood vessels of the ocular fundus in CN(-/-) mice. In addition, mesothelial cells, which usually express calponin h1 in normal (CN(+/+)) mice, were retracted in the CN(-/-) mice. When fluorescein was injected i.v. into mice, the CN(-/-) mice exhibited a greater and more rapid leakage of fluorescein from the blood vessels of the ocular fundus compared with the CN(+/+) mice. In the CN(-/-) mice receiving i.v. inoculations of B16 melanoma cells, significantly more metastatic nodules were formed in the lung than in the CN(+/+) mice. When B16 melanoma cells were injected i.p., the severity of peritonitis carcinomatosa was greater in CN(-/-) than in CN(+/+) mice. These results indicate that calponin h1 plays an important role in the regulation of the integrity of the blood vessels and peritoneum, which in turn is an important factor influencing the frequency of cancer metastasis. The CN(-/-) mice, which exhibit fragile blood vessels and peritoneum, could serve as sensitive and useful host models to investigate cancer metastasis.
Positioning of Store Brands

We examine the retailer's store brand positioning problem. Our game-theoretic model helps us identify a set of conditions under which the optimal strategy for the retailer is to position the store brand as close as possible to the stronger national brand. In three empirical studies, we examined whether market data are consistent with some of the implications of our model. In the first study, using observational data from two US supermarket chains, we found that store brands are more likely to target stronger national brands. Our second study estimated cross-price effects in 19 product categories, and found that only in categories with high-quality store brands, store brand and the leading national brand compete more intensely with each other than with the secondary national brand. In a third product perception study, we found that although explicit targeting by store brands influenced consumer perceptions of physical similarity, it had no influence on consumers' perceptions of overall or product quality similarity. While it appears that retailers do follow a positioning strategy consistent with our model, it changes buying behavior in the intended fashion only if the store brand offers quality comparable to the leading national brands.
HEAT repeats – versatile arrays of amphiphilic helices working in crowded environments?

ABSTRACT Cellular proteins do not work in isolation. Instead, they often function as part of large macromolecular complexes, which are transported and concentrated into specific cellular compartments and function in a highly crowded environment. A central theme of modern cell biology is to understand how such macromolecular complexes are assembled efficiently and find their destinations faithfully. In this Opinion article, we will focus on HEAT repeats, flexible arrays of amphiphilic helices found in many eukaryotic proteins, such as karyopherins and condensins, and discuss how these uniquely designed helical repeats might underlie dynamic protein–protein interactions and support cellular functions in crowded environments. We will make bold speculations on functional similarities between the action of HEAT repeats and intrinsically disordered regions (IDRs) in macromolecular phase separation. Potential contributions of HEAT–HEAT interactions, as well as cooperation between HEATs and IDRs, to mesoscale organelle assembly will be discussed. Summary: HEAT repeats, repetitive arrays of amphiphilic helices found in many eukaryotic proteins, flexibly change their own conformations and support dynamic protein–protein interactions in crowded environments in the cell.