Miracle-dz/UniFAR-FTUs huggingface dataset:
Automatic target recognition for hyperspectral imagery using high-order statistics

Due to recent advances in hyperspectral imaging sensors many subtle unknown signal sources that cannot be resolved by multispectral sensors can be now uncovered for target detection, discrimination, and identification. Because the information about such sources is generally not available, automatic target recognition (ATR) presents a great challenge to hyperspectral image analysts. Many approaches developed for ATR are based on second-order statistics in the past years. This paper investigates ATR techniques using high order statistics. For ATR in hyperspectral imagery, most interesting targets usually occur with low probabilities and small population and they generally cannot be described by second-order statistics. Under such circumstances, using high-order statistics to perform target detection have been shown by experiments in this paper to be more effective than using second order statistics. In order to further address a challenging issue in determining the number of signal sources needed to be detected, a recently developed concept of virtual dimensionality (VD) is used to estimate this number. The experiments demonstrate that using high-order statistics-based techniques in conjunction with the VD to perform ATR are indeed very effective
Wideband sonar imaging via compressed sensing

In order to solve the contradiction of high azimuth resolution and wide swath in sonar and radar imaging, narrowband compressed sensing (CS) imaging has been studied in depth. This paper studies the wideband sonar imaging method via CS. Wideband CS imaging model is constructed. Scaling and Doppler frequency shift are considered in the model. The effect of wideband signal to traditional narrowband model is analyzed. Wideband CS imaging method is constructed. A modified ℓ1-norm minimization algorithm is proposed. It is shown that it is possible to apply CS to wideband sonar imaging. Numerical experiments are conducted and demonstrates the analysis.
Noradrenergic Signaling in Infralimbic Cortex Increases Cell Excitability and Strengthens Memory for Fear Extinction

Emotional arousal strengthens memory. This is most apparent in aversive conditioning, in which the stress-related neurotransmitter norepinephrine (NE) enhances associations between sensory stimuli and fear-inducing events. In contrast to conditioning, extinction decreases fear responses, and is thought to form a new memory. It is not known, however, whether NE is necessary for extinction learning. Previous work has shown that the infralimbic prefrontal cortex (IL) is a site of extinction consolidation. Here, we show that blocking noradrenergic β-receptors in IL before extinction training impaired retrieval of extinction the following day, consistent with a weakened extinction memory. We further found that the sequelae of β-receptor activation, including protein kinase A (PKA), gene transcription and translation in IL, are necessary for extinction. To determine whether activation of this cascade modulates IL excitability, we measured the response of IL pyramidal neurons to injected current. NE increased the excitability of IL neurons in a β-receptor- and PKA-dependent manner. We suggest that NE released in IL during fear extinction activates a PKA-mediated molecular cascade that strengthens extinction memory. Thus, emotional arousal evoked by conditioned fear paradoxically promotes the subsequent extinction of that fear, thereby ensuring behavioral flexibility.
An Accounting-Based Characteristic Model for Asset Pricing

The paper presents an accounting framework for identifying characteristics that indicate expected returns. A model links expected returns to expected earnings and earnings growth, so a characteristic indicates expected returns if it indicates expected earnings and earnings growth that the market prices as being at risk. In applying the framework, the paper confirms book-to-price (B/P) as a valid characteristic in asset pricing: B/P is associated with higher expected earnings growth and also captures the risk of that growth not being realized. However, the framework also points to the forward earning-to-price (E/P) as a risk characteristic. Indeed, E/P, rather than B/P, is the relevant characteristic when there is no expected earnings growth, but the weight shifts to B/P with growth. The framework also enables the separation of the expected return for operating risk from that due to financing risk. With this separation, the paper revisits the puzzling negative relation that has been observed between leverage and realized returns, a finding that has been attributed to failure to control for operating risk. We find a positive relation between leverage and returns when operating risk characteristics identified by our model are recognized.
FIT CAMP A BEHAVIORAL WEIGHT LOSS PROGRAM THE EFFECTS OF SELF-MONITORING, SOCIAL SUPPORT, ATTENDANCE, AND MOTIVATION

OF THESIS FIT CAMP A BEHAVIORAL WEIGHT LOSS PROGRAM THE EFFECTS OF SELF-MONITORING, SOCIAL SUPPORT, ATTENDANCE, AND MOTIVATION Almost half of Americans between 17 and 24 years of age are enrolled in higher education. College is an important life transition period when many young adults establish independence and adopt lasting behavior patterns, especially with regard to diet and physical activity. The first years of college are often associated with weight gain therefore making weight loss and weight gain prevention interventions necessary in this population. Behavioral weight loss programs (BWLP) have shown to be effective in adults, however, to our knowledge, there have been no reports of BWLP focused solely on college-aged young adults. This study compared a 10-week online behavioral weight loss program to a 10-week face-to-face program on the main outcomes of weight loss, change in body fat percentage, and change in physical activity among college students. Correlates of weight loss including self-monitoring, social support, attendance, selfefficacy, and motivation were also examined. Results showed motivation decreased over time, motivation was positively correlated with weight loss, and selfefficacy increased over time.
Novel Two-Step Classifier for Torsades de Pointes Risk Stratification from Direct Features

While pre-clinical Torsades de Pointes (TdP) risk classifiers had initially been based on drug-induced block of hERG potassium channels, it is now well established that improved risk prediction can be achieved by considering block of non-hERG ion channels. The current multi-channel TdP classifiers can be categorized into two classes. First, the classifiers that take as input the values of drug-induced block of ion channels (direct features). Second, the classifiers that are built on features extracted from output of the drug-induced multi-channel blockage simulations in the in-silico models (derived features). The classifiers built on derived features have thus far not consistently provided increased prediction accuracies, and hence casts doubt on the value of such approaches given the cost of including biophysical detail. Here, we propose a new two-step method for TdP risk classification, referred to as Multi-Channel Blockage at Early After Depolarization (MCB@EAD). In the first step, we classified the compound that produced insufficient hERG block as non-torsadogenic. In the second step, the role of non-hERG channels to modulate TdP risk are considered by constructing classifiers based on direct or derived features at critical hERG block concentrations that generates EADs in the computational cardiac cell models. MCB@EAD provides comparable or superior TdP risk classification of the drugs from the direct features in tests against published methods. TdP risk for the drugs highly correlated to the propensity to generate EADs in the model. However, the derived features of the biophysical models did not improve the predictive capability for TdP risk assessment.
Complete Restriction of Fluoroquinolone Use to Control an Outbreak of Clostridium difficile Infection at a Community Hospital

Objective. To review the effect of interventions, including a complete restriction in the use of fluoroquinolones (FQs), used to control an outbreak of hospital-onset Clostridium difficile infection (HO-CDI) caused primarily by the epidemic North American pulsed-field gel electrophoresis type 1 strain. Design. Retrospective cohort and case-control study of all episodes of HO-CDI both before and after 2 interventions. Setting. Community hospital; January 1, 2005, through March 31, 2007. Interventions. Complete, 5-month, facility-wide restriction of fluoroquinolone use, during which a change in the environmental-services contractor occurred. Results. During a 27-month period, 319 episodes of HO-CDI occurred. The hospital-wide mean defined daily doses of antimicrobials decreased 22% after restricting FQ use, primarily because of a 66% decrease in the use of FQs. The interventions were also associated with a significant change in the HO-CDI incidence trends and with an absolute decrease of 22% in HO-CDI cases caused by the epidemic strain (from 66% before the intervention period to 44% during and after the intervention period; P = .02). Univariate analysis revealed that case patients with HO-CDI due to the epidemic strain were more likely than control patients, who did not have diarrhea, to receive a FQ, whereas case patients with HO-CDI due to a nonepidemic strain were not. However, FQ use was not significantly associated with HO-CDI in multivariable analysis. Conclusions. An outbreak of epidemic-strain HO-CDI was controlled at a community hospital after an overall decrease in antimicrobial use, primarily because of a restriction of FQ use and a change in environmental-services contractors. The restriction of FQ use may be useful as an adjunct control measure in a healthcare facilities during outbreaks of epidemic-strain HO-CDI.
VLBI observations of seven BL Lacertae objects from RGB sample

We present EVN observations of seven BL Lac objects selected from the RGB sample. To investigate the intrinsic radiation property of BL Lac objects, we estimated the Doppler factor with the VLA or MERLIN core and the total 408 MHz luminosity for a sample of 170 BL Lac objects. The intrinsic ( comoving) synchrotron peak frequency was then calculated by using the estimated Doppler factor. Assuming a Lorentz factor of 5, the viewing angle of jets was constrained. The high-resolution VLBI images of seven sources all show a core-jet structure. We estimated the proper motions of three sources with the VLBI archive data, and find that the apparent speed increases with the distance of components to the core for all of them. In our BL Lacs sample, the Doppler factor of LBLs is systematically larger than that of IBLs and HBLs. We find a significant anti-correlation between the total 408 MHz luminosity and the intrinsic synchrotron peak frequency. However, the scatter is much larger than for the blazar sequence. Moreover, we find a significant positive correlation between the viewing angle and the intrinsic synchrotron peak frequency. The BL Lac objects show a continuous distribution on the viewing angle. While LBLs have a smaller viewing angle than that of IBLs and HBLs, IBLs are comparable to HBLs. We conclude that the intrinsic synchrotron peak frequency is not only related to the intrinsic radio power ( though with a large scatter), but also to the viewing angle for the present sample.
High frequency of GJB2 mutation W24X among Slovak Romany (Gypsy) patients with non-syndromic hearing loss (NSHL).

Mutations in the GJB2 gene (connexin 26) represent a major cause of autosomal recessive non-syndromic hearing loss (NSHL) worldwide. In most Caucasian populations, the 35delG mutation in this gene was found to account for up to 50% of cases of the genetic non-syndromic childhood deafness. In populations of non-European ethnic background, other GJB2 gene mutations are occasionally common, e.g. 167delT in Ashkenazi Jews, R143W in Africaans and 235delC in Koreans. In this work, DNA samples from 54 unrelated NSHL patients from endogamous and inbred population of Slovak Roms (Gypsies) from Eastern Slovakia were screened for GJB2 mutations. The coding region of the GJB2 gene of patients was sequenced and mutations W24X, R127H, V153I, L90P and V37I were found. In Slovak Romany population, mutation W24X accounts for 23.2%, R127H for 19.4%, 35delG for 8.3%, V153I for 3.7%, L90P for 3.7% and V37I for 0.9% of screened chromosomes. As the W24X mutation was previously found in India and Pakistan, were from the European Romanies originate, it was brought by the European Romnanies from their Indian homeland. The carrier frequency of 35delG was estimated for Slovak non-Romany population to be 3.3%, and for Slovak Romany population to 0.88%. The carrier frequency of W24X varied in different Slovak Romany subpopulations from 0.0% up to 26.1%.
Fire Drives Transcontinental Variation in Tree Birch Defense against Browsing by Snowshoe Hares

Fire has been the dominant disturbance in boreal America since the Pleistocene, resulting in a spatial mosaic in which the most fire occurs in the continental northwest. Spatial variation in snowshoe hare (Lepus americanus) density reflects the fire mosaic. Because fire initiates secondary forest succession, a fire mosaic creates variation in the abundance of early successional plants that snowshoe hares eat in winter, leading to geographic variation in hare density. We hypothesize that fire is the template for a geographic mosaic of natural selection: where fire is greatest and hares are most abundant, hare browsing has most strongly selected juvenile‐phase woody plants for defense. We tested the hypothesis at multiple spatial scales using Alaska birch (Betula neoalaskana) and white birch (Betula papyrifera). We also examined five alternative hypotheses for geographic variation in antibrowsing defense. The fire‐hare‐defense hypothesis was supported at transcontinental, regional, and local scales; alternative hypotheses were rejected. Our results link transcontinental variation in species interactions to an abiotic environmental driver, fire. Intakes of defense toxins by Alaskan hares exceed those by Wisconsin hares, suggesting that the proposed selection mosaic may coincide with a geographic mosaic of coevolution.
Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation

Eukaryotic initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor for eIF2 and a critical regulator of protein synthesis, (e.g., as part of the integrated stress response). Certain mutations in the EIF2B genes cause leukoencephalopathy with vanishing white matter (VWM), an often serious neurological disorder. Comprising 5 subunits, α–ε (eIF2Bε being the catalytic one), eIF2B has always been considered an αβγδε heteropentamer. We have analyzed the subunit interactions within mammalian eIF2B by using a combination of mass spectrometry and in vivo studies of overexpressed complexes to gain further insight into the subunit arrangement of the complex. Our data reveal that eIF2B is actually decameric, a dimer of eIF2B(βγδε) tetramers stabilized by 2 copies of eIF2Bα. We also demonstrate a pivotal role for eIF2Bδ in the formation of eIF2B(βγδε) tetramers. eIF2B(αβγδε)2 decamers show greater binding to eIF2 than to eIF2B(βγδε) tetramers, which may underlie the increased activity of the former. We examined the levels of eIF2B subunits in a panel of different mouse tissues and identified different levels of eIF2B subunits, particularly eIF2Bα, which implies heterogeneity in the cellular proportions of eIF2B(αβγδε) and eIF2B(βγδε) complexes, with important implications for the regulation of translation in individual cell types. —Wortham, N. C. , Martinez, M. , Gordiyenko, Y. , Robinson, C. V. , Proud, C. G. Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation. FASEB J. 28, 2225–2237 (2014). www.fasebj. org
Wireless access with blind collision-multiplicity detection and retransmission diversity for quasi-static channels

Wireless multiple-access protocols using retransmission diversity resolve packet collisions through source separation techniques. Retransmissions are applied to achieve the necessary diversity level to determine the collision multiplicity blindly, whose proper detection is essential for good resolution performance. The so-called network-assisted diversity multiple access (NDMA) employs the rank test (RT) method for blind multiplicity detection, but static channel parameters throughout the retransmissions and the tight control of the transmitter phase are required. In this paper, a superior blind collision multiplicity-detection technique is introduced by combining the minimum description length criterion and a variation of the RT method. Collision resolution is accomplished through independent component analysis (ICA). Unlike blind NDMA,the new protocol, named ICA-NDMA, works in quasi-static fading channels, and does not need any phase control. Extensive performance analyses corroborate the performance advantages offered by ICA-NDMA.
Barriers to providing palliative care in long-term care facilities.

OBJECTIVE To assess challenges in providing palliative care in long-term care (LTC) facilities from the perspective of medical directors. DESIGN Cross-sectional mailed survey. A questionnaire was developed, reviewed, pilot-tested, and sent to 450 medical directors representing 531 LTC facilities. Responses were rated on 2 different 5-point scales. Descriptive analyses were conducted on all responses. SETTING All licensed LTC facilities in Ontario with designated medical directors. PARTICIPANTS Medical directors in the facilities. MAIN OUTCOME MEASURES Demographic and practice characteristics of physicians and facilities, importance of potential barriers to providing palliative care, strategies that could be helpful in providing palliative care, and the kind of training in palliative care respondents had received. RESULTS Two hundred seventy-five medical directors (61%) representing 302 LTC facilities (57%) responded to the survey. Potential barriers to providing palliative care were clustered into 3 groups: facility staff's capacity to provide palliative care, education and support, and the need for external resources. Two thirds of respondents (67.1%) reported that inadequate staffing in their facilities was an important barrier to providing palliative care. Other barriers included inadequate financial reimbursement from the Ontario Health Insurance Program (58.5%), the heavy time commitment required (47.3%), and the lack of equipment in facilities (42.5%). No statistically significant relationship was found between geographic location or profit status of facilities and barriers to providing palliative care. Strategies respondents would use to improve provision of palliative care included continuing medical education (80.0%), protocols for assessing and monitoring pain (77.7%), finding ways to increase financial reimbursement for managing palliative care residents (72.1%), providing educational material for facility staff (70.7%), and providing practice guidelines related to assessing and managing palliative care patients (67.8%). CONCLUSION Medical directors in our study reported that their LTC facilities were inadequately staffed and lacked equipment. The study also highlighted the specialized role of medical directors, who identified continuing medical education as a key strategy for improving provision of palliative care.
Piperacillin versus cefazolin given perioperatively to high-risk patients who undergo open cholecystectomy: a double-blind, randomized trial.

OBJECTIVE To study the efficacy, microbiologic features and toxicity of prophylactic cefazolin versus prophylactic piperacillin in high-risk patients who undergo open cholecystectomy. DESIGN Double-blind randomized trial with follow-up for 6 weeks postoperatively. SETTING An 850-bed community hospital, located in a major Canadian city. Patients admitted to hospital who satisfied published criteria for being at high-risk for infection after open cholecystectomy were entered into the protocol, and those who satisfied the criteria and provided consent were entered into the study. Eighty-one patients were randomly assigned by computer to receive either piperacillin or cefazolin as the prophylactic agent. INTERVENTIONS Open cholecystectomy. MAIN OUTCOME Provides detailed information on the organisms found in the biliary tree in patients with acute cholecystitis, assesses the in-vitro activity of cefazolin versus piperacillin against the isolated organisms, expecting that piperacillin would be much more active against isolated anaerobes and gram-negative bacteria. RESULTS Bactobilia was documented in 42% of patients in the cefazolin group and 29% of patients in the piperacillin group. Piperacillin was active in vitro against 94% of all isolates versus 56% for cefazolin (p < 0.005, McNemar's test). Adverse effects and toxicities in both the piperacillin and cefazolin group were low and were not serious. CONCLUSIONS Both piperacillin and cefazolin are safe and effective prophylactic antimicrobials for high-risk patients who undergo open cholecystectomy. However, piperacillin had a much wider spectrum of in-vitro activity against the isolated pathogens, especially Enterococcus sp. , Enterobacter cloacae and the anaerobes.
Poverty and HIV/AIDS in Sub-Saharan Africa: Implications for Psychological Well-being

The study examines the literature on poverty and HIV/AIDS in an effort to explore the various psychological resources available for affected individuals. Poverty is an increased risk for HIV and AIDS for a majority of the citizens of sub-Saharan Africa, and also lowered their subjective well-being. Furthermore, research evidence revealed that the relationship between poverty and subjective well-being is mediated by the intervention of such psychological variables as locus of control, self esteem, depression and coping strategies among others. Psychological resources for positive well-being that could ameliorate the potentially devastating combined effects of HIV and poverty are suggested.
Children's Strategies for Creating Playspaces: Negotiating Independence in Rural Bolivia

Recent research in the new social studies of childhood recognises that children are competent social actors who play an active part in their social worlds (Waksler 1991; Mayall 1994; Caputo 1995; Waksler 1996). Yet there are still relatively few studies which document the ways in which children devise ways to counteract adult's power and control over their lives. However, although the agency of children is important in understanding their capacities (Sibley 1991), it must be acknowledged that children also face limitations. The aim of this chapter is to consider how rural children in Bolivia actively negotiate ways to assert their autonomy despite being constrained by adults who enforce boundaries of time and space (James 1993; Ennew 1994; Sibley 1995). Adult-imposed limits confine children, yet children's resourcefulness and competencies enable them to create strategies for controlling their own use of time and space.