Miracle-dz/UniFAR-FTUs huggingface dataset:
Grease Degradation in R0F Bearing Tests

This paper is the second in a series that examines grease lubrication mechanisms and failure in rolling element bearings. The aim of the work was to understand the grease condition changes during use and the relationship to lubrication performance and failure. R0F bearing tests were carried out with two lithium hydroxystearate greases and the effects of the temperature, the speed, and the additive package on lubrication life was studied. Post-test, one pair of bearings (fail and non-fail) was dismantled and grease distribution and condition assessed. IR spectroscopy was then used to determine the lubricant composition and the oxidation level of the grease remaining on the shields, the inner raceway, and the cage pockets. The additive package increased the grease life by 100-700% depending on the test condition. Most of the grease remaining in the bearing was found on the shields, with only trace amounts in the cage pockets or close to the rolling track. The IR analysis showed that the composition of the shield sample was similar to the fresh grease although the base oil oxidation was evident and this increased with the running time. The cage pocket and inner raceway films contained a number of chemical species; these included the base oil and the thickener and their oxidation products. The study concludes that after an initial running-in period the “active” lubricant is heavily degraded grease, which contains oxidized species from the base oil and the thickener. Different failure mechanisms are identified depending on the test condition. High-speed tests that fail relatively quickly are due to poor boundary lubrication performance or cage failure rather than the lubricant reaching its “oxidation” limit. Long-term tests at slower speeds suffer considerable base oil oxidation. Under these conditions, failure is due to a reduction in the amount and/or mobility of the raceway lubricant.
Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast *

The majority of mitochondrial proteins are encoded in the nuclear genome, translated in the cytoplasm, and directed to the mitochondria by an N-terminal presequence that is cleaved upon import. Recently, N-proteome catalogs have been generated for mitochondria from yeast and from human U937 cells. Here, we applied the subtiligase method to determine N-termini for 327 proteins in mitochondria isolated from mouse liver and kidney. Comparative analysis between mitochondrial N-termini from mouse, human, and yeast proteins shows that whereas presequences are poorly conserved at the sequence level, other presequence properties are extremely conserved, including a length of ∼20–60 amino acids, a net charge between +3 to +6, and the presence of stabilizing amino acids at the N-terminus of mature proteins that follow the N-end rule from bacteria. As in yeast, ∼80% of mouse presequence cleavage sites match canonical motifs for three mitochondrial peptidases (MPP, Icp55, and Oct1), whereas the remainder do not match any known peptidase motifs. We show that mature mitochondrial proteins often exist with a spectrum of N-termini, consistent with a model of multiple cleavage events by MPP and Icp55. In addition to analysis of canonical targeting presequences, our N-terminal dataset allows the exploration of other cleavage events and provides support for polypeptide cleavage into two distinct enzymes (Hsd17b4), protein cleavages key for signaling (Oma1, Opa1, Htra2, Mavs, and Bcs2l13), and in several cases suggests novel protein isoforms (Scp2, Acadm, Adck3, Hsdl2, Dlst, and Ogdh). We present an integrated catalog of mammalian mitochondrial N-termini that can be used as a community resource to investigate individual proteins, to elucidate mechanisms of mammalian mitochondrial processing, and to allow researchers to engineer tags distally to the presequence cleavage.
Genome-wide maps of alkylation damage, repair, and mutagenesis in yeast reveal mechanisms of mutational heterogeneity

DNA base damage is an important contributor to genome instability, but how the formation and repair of these lesions is affected by the genomic landscape and contributes to mutagenesis is unknown. Here, we describe genome-wide maps of DNA base damage, repair, and mutagenesis at single nucleotide resolution in yeast treated with the alkylating agent methyl methanesulfonate (MMS). Analysis of these maps revealed that base excision repair (BER) of alkylation damage is significantly modulated by chromatin, with faster repair in nucleosome-depleted regions, and slower repair and higher mutation density within strongly positioned nucleosomes. Both the translational and rotational settings of lesions within nucleosomes significantly influence BER efficiency; moreover, this effect is asymmetric relative to the nucleosome dyad axis and is regulated by histone modifications. Our data also indicate that MMS-induced mutations at adenine nucleotides are significantly enriched on the nontranscribed strand (NTS) of yeast genes, particularly in BER-deficient strains, due to higher damage formation on the NTS and transcription-coupled repair of the transcribed strand (TS). These findings reveal the influence of chromatin on repair and mutagenesis of base lesions on a genome-wide scale and suggest a novel mechanism for transcription-associated mutation asymmetry, which is frequently observed in human cancers.
The Influence of Facial Sex Cues on Emotional Expression Categorization is not Fixed

The speed of recognizing facial expressions of emotion is influenced by a range of factors including other concurrently present facial attributes, like a person’s sex. Typically, when participants categorize happy and angry expressions on male and female faces, they are faster to categorize happy than angry expressions displayed by females, but not displayed by males. Using the same emotional faces across tasks, we demonstrate that this influence of sex cues on emotion categorization is dependent on the other faces recently encountered in an experiment. Altering the salience of gender by presenting male and female faces in separate emotion categorization tasks rather than together in a single task changed the influence of sex cues on emotion categorization, whereas changing the evaluative dimension by presenting happy and angry expressions in separate tasks alongside neutral faces rather than together within 1 task did not. These results suggest that the way facial attributes influence emotion categorization depends on the situation in which the faces are encountered and specifically on what information is made salient within or across tasks by other recently encountered faces.
Multicomponent Palliative Care Interventions in Advanced Chronic Diseases: A Systematic Review

Background: Many patients live with serious chronic or terminal illnesses. Multicomponent palliative care interventions have been increasingly utilized in patient care; however, it is unclear what is being implemented and who is delivering these interventions. Objectives: To (1) describe the delivery of multicomponent palliative care interventions, (2) characterize the disciplines delivering care, (3) identify the components being implemented, and (4) analyze whether the number of disciplines or components being implemented are associated with positive outcomes. Design: Systematic review. Study Selection: English-language articles analyzing multicomponent palliative care interventions. Outcomes Measured: Delivery of palliative interventions by discipline, components of palliative care implemented, and number of positive outcomes (eg, pain, quality of life). Results: Our search strategy yielded 71 articles, which detailed 64 unique multicomponent palliative care interventions. Nurses (n = 64, 88%) were most often involved in delivering care, followed by physicians (n = 43, 67%), social workers (n = 33, 52%), and chaplains (n = 19, 30%). The most common palliative care components patients received were symptom management (n = 56, 88%), psychological support/counseling (n = 52, 81%), and disease education (n = 48, 75%). Statistical analysis did not uncover an association between number of disciplines or components and positive outcomes. Conclusions: While there has been growth in multicomponent palliative care interventions over the past 3 decades, important aspects require additional study such as better inclusion of key groups (eg, chronic obstructive pulmonary disease, end-stage renal disease, minorities, older adults); incorporating core components of palliative care (eg, interdisciplinary team, integrating caregivers, providing spiritual support); and developing ways to evaluate the effectiveness of interventions that can be readily replicated and disseminated.
Maternal Depression and Anxiety, Social Synchrony, and Infant Regulation of Negative and Positive Emotions

Maternal postpartum depression (PPD) exerts long-term negative effects on infants; yet the mechanisms by which PPD disrupts emotional development are not fully clear. Utilizing an extreme-case design, 971 women reported symptoms of depression and anxiety following childbirth and 215 high and low on depressive symptomatology reported again at 6 months. Of these, mothers diagnosed with major depressive disorder (n = 22), anxiety disorders (n = 19), and controls (n = 59) were visited at 9 months. Mother-infant interaction was microcoded for maternal and infant’s social behavior and synchrony. Infant negative and positive emotional expression and self-regulation were tested in 4 emotion-eliciting paradigms: anger with mother, anger with stranger, joy with mother, and joy with stranger. Infants of depressed mothers displayed less social gaze and more gaze aversion. Gaze and touch synchrony were lowest for depressed mothers, highest for anxious mothers, and midlevel among controls. Infants of control and anxious mothers expressed less negative affect with mother compared with stranger; however, maternal presence failed to buffer negative affect in the depressed group. Maternal depression chronicity predicted increased self-regulatory behavior during joy episodes, and touch synchrony moderated the effects of PPD on infant self-regulation. Findings describe subtle microlevel processes by which maternal depression across the postpartum year disrupts the development of infant emotion regulation and suggest that diminished social synchrony, low differentiation of attachment and nonattachment contexts, and increased self-regulation during positive moments may chart pathways for the cross-generational transfer of emotional maladjustment from depressed mothers to their infants.
CNN Based Learning Using Reflection and Retinex Models for Intrinsic Image Decomposition

Most of the traditional work on intrinsic image decomposition rely on deriving priors about scene characteristics. On the other hand, recent research use deep learning models as in-and-out black box and do not consider the well-established, traditional image formation process as the basis of their intrinsic learning process. As a consequence, although current deep learning approaches show superior performance when considering quantitative benchmark results, traditional approaches are still dominant in achieving high qualitative results. In this paper, the aim is to exploit the best of the two worlds. A method is proposed that (1) is empowered by deep learning capabilities, (2) considers a physics-based reflection model to steer the learning process, and (3) exploits the traditional approach to obtain intrinsic images by exploiting reflectance and shading gradient information. The proposed model is fast to compute and allows for the integration of all intrinsic components. To train the new model, an object centered large-scale datasets with intrinsic ground-truth images are created. The evaluation results demonstrate that the new model outperforms existing methods. Visual inspection shows that the image formation loss function augments color reproduction and the use of gradient information produces sharper edges. Datasets, models and higher resolution images are available at https://ivi.fnwi. uva.nl/cv/retinet.
A liquid-liquid transition in supercooled aqueous solution related to the HDA-LDA transition

Unmasking supercooled water transitions The unusual thermodynamic properties of water suggest that when supercooled, a second critical point should exist between two liquid phases that differ in density. Pure water crystallizes before such conditions can be reached. Woutersen et al. studied hydrazinium trifluoroacetate solutions that have similar hydrogen bonding to that of water. They observed a liquid-liquid transition near 190 K by using infrared spectroscopy and calorimetry. The liquid states were analogous to the predicted high- and low-density amorphous phases of water. Science, this issue p. 1127 Supercooled hydrazinium trifluoroacetate solutions exhibit reversible liquid-liquid transitions at ~190 kelvin. Simulations and theory suggest that the thermodynamic anomalies of water may be related to a phase transition between two supercooled liquid states, but so far this phase transition has not been observed experimentally because of preemptive ice crystallization. We used calorimetry, infrared spectroscopy, and molecular dynamics simulations to investigate a water-rich hydrazinium trifluoroacetate solution in which the local hydrogen bond structure surrounding a water molecule resembles that in neat water at elevated pressure, but which does not crystallize upon cooling. Instead, this solution underwent a sharp, reversible phase transition between two homogeneous liquid states. The hydrogen-bond structures of these two states are similar to those established for high- and low-density amorphous (HDA and LDA) water. Such structural similarity supports theories that predict a similar sharp transition in pure water under pressure if ice crystallization could be suppressed.
Curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway

Abstract We have previously reported that curcumin inhibits urothelial tumor development in a rat bladder carcinogenesis model. In this study, we report that curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway. Curcumin inhibits IGF2 expression at the transcriptional level and decreases the phosphorylation levels of IGF1R and IRS-1 in bladder cancer cells and N-methyl-N-nitrosourea (MNU)-induced urothelial tumor tissue. Ectopic expression of IGF2 and IGF1R, but not IGF1, in bladder cancer cells restored this process, suggesting that IGF2 is a target of curcumin. Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway. In summary, our results reveal that suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway is one of the mechanisms of action of curcumin. Our findings suggest a new therapeutic strategy against human bladder cancer caused by aberrant activation of IGF2, which are useful for translational application of curcumin.
Local transformations of the hippocampal cognitive map

The mechanisms behind grid cell changes When grid cells were first discovered in the brain, the grids were considered to have rigid coordinates beyond the borders of the testing environments. However, recent findings suggest that the grid cell pattern can be altered easily by changing the space of the enclosure. But how? Krupic et al. discovered that local changes in the geometry of the environment shifted individual neighboring grid fields, while more distant fields remained unchanged. Thus, changes to the grid structure are localized. Stable landmarks continue to exert an effect on most grid cells, whereas the ones close to changed borders are modified. Science, this issue p. 1143 Individual grid fields in the brain shift by different amounts with changes in the geometry of the enclosure. Grid cells are neurons active in multiple fields arranged in a hexagonal lattice and are thought to represent the “universal metric for space. ” However, they become nonhomogeneously distorted in polarized enclosures, which challenges this view. We found that local changes to the configuration of the enclosure induce individual grid fields to shift in a manner inversely related to their distance from the reconfigured boundary. The grid remained primarily anchored to the unchanged stable walls and showed a nonuniform rescaling. Shifts in simultaneously recorded colocalized grid fields were strongly correlated, which suggests that the readout of the animal’s position might still be intact. Similar field shifts were also observed in place and boundary cells—albeit of greater magnitude and more pronounced closer to the reconfigured boundary—which suggests that there is no simple one-to-one relationship between these three different cell types.
Impact of high‐mobility group box 1 on melanocytic survival and its involvement in the pathogenesis of vitiligo

Vitiligo is attributable to loss of functional melanocytes and is the most common acquired depigmenting disorder. Oxidative stress and intense ultraviolet irradiation are known to aggravate this condition. The nonhistone high‐mobility group box 1 (HMGB1) DNA‐binding protein is a physiological activator of immune responses, cellular proliferation and cell death. Although it is implicated in the pathogenesis of autoimmune diseases and cutaneous disorders, the precise role of HMGB1 in melanocytes has yet to be studied.
Effect of Abrasion on the Air Permeability & Mass Loss of Breathable-Coated Fabrics

This paper presents a study on air permeability and relative mass loss in abraded breathablecoated fabrics. The abrasion treatment of different structured samples as well as the outer and reverse sides of specimens was done on a Martindale tester, varying the number of abrasion cycles. Considerable attention was devoted to the importance of the coating and textile substrate abrasion. Trends in the relationships between the abrasion cycles and the above-mentioned properties of the coated fabrics are discussed. The results support the nonlinear function approach nonlinear function.
BCA2/Rabring7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of IκBα

ABSTRACT BCA2/Rabring7 is a BST2 cofactor that promotes the lysosomal degradation of trapped HIV-1 virions but also functions as a BST2-independent anti-HIV factor by targeting Gag for lysosomal degradation. Since many antiviral factors regulate the NF-κB innate signaling pathway, we investigated whether BCA2 is also connected to this proinflammatory cascade. Here, we show for the first time that BCA2 is induced by NF-κB-activating proinflammatory cytokines and that upregulation of BCA2 provides regulatory negative feedback on NF-κB. Specifically, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IκBα, which in turn enhances the sequestration of NF-κB components in the cytoplasm. Since HIV-1 utilizes NF-κB to promote proviral transcription, the BCA2-mediated inhibition of NF-κB significantly decreases the transcriptional activity of HIV-1 (up to 4.4-fold in CD4+ T cells). Therefore, our findings indicate that BCA2 poses an additional barrier to HIV-1 infection: not only does BCA2 prevent assembly and release of nascent virions, it also significantly restricts HIV-1 transcription by inhibiting the NF-κB pathway. IMPORTANCE Understanding the interactions between HIV-1 and its host cells is highly relevant to the design of new drugs aimed at eliminating HIV-1 from infected individuals. We have previously shown that BCA2, a cofactor of BST2 in the restriction of HIV-1, also prevents virion assembly in a BST2-independent manner. In this study, we found that BCA2 negatively regulates the NF-κB pathway—a signaling cascade necessary for HIV-1 replication and infectivity—which in turn detrimentally affects proviral transcription and virus propagation. Thus, our results indicate that, besides its previously described functions as an antiviral factor, BCA2 poses an additional barrier to HIV-1 replication at the transcriptional level.
The spread of true and false news online

Lies spread faster than the truth There is worldwide concern over false news and the possibility that it can influence political, economic, and social well-being. To understand how false news spreads, Vosoughi et al. used a data set of rumor cascades on Twitter from 2006 to 2017. About 126,000 rumors were spread by ∼3 million people. False news reached more people than the truth; the top 1% of false news cascades diffused to between 1000 and 100,000 people, whereas the truth rarely diffused to more than 1000 people. Falsehood also diffused faster than the truth. The degree of novelty and the emotional reactions of recipients may be responsible for the differences observed. Science, this issue p. 1146 A large-scale analysis of tweets reveals that false rumors spread further and faster than the truth. We investigated the differential diffusion of all of the verified true and false news stories distributed on Twitter from 2006 to 2017. The data comprise ~126,000 stories tweeted by ~3 million people more than 4.5 million times. We classified news as true or false using information from six independent fact-checking organizations that exhibited 95 to 98% agreement on the classifications. Falsehood diffused significantly farther, faster, deeper, and more broadly than the truth in all categories of information, and the effects were more pronounced for false political news than for false news about terrorism, natural disasters, science, urban legends, or financial information. We found that false news was more novel than true news, which suggests that people were more likely to share novel information. Whereas false stories inspired fear, disgust, and surprise in replies, true stories inspired anticipation, sadness, joy, and trust. Contrary to conventional wisdom, robots accelerated the spread of true and false news at the same rate, implying that false news spreads more than the truth because humans, not robots, are more likely to spread it.