Miracle-dz/UniFAR-FTUs huggingface dataset:
Cetuximab as Second-Line Therapy in Patients with Metastatic Esophageal Adenocarcinoma: A Phase II Southwest Oncology Group Study (S0415)

Introduction: Esophageal adenocarcinomas commonly express the epidermal growth factor receptor. This trial assessed the 6-month overall survival probability in metastatic esophageal cancer patients treated with cetuximab as second-line therapy. Methods: This was a multicenter, open-label phase II study of single-agent cetuximab for metastatic esophageal adenocarcinoma patients who failed one prior chemotherapy regimen. Adequate organ function and Zubrod performance status of 0 to 2 were required. Patients received cetuximab 400 mg/m2 intravenously (IV) on week 1 and 250 mg/m2 IV weekly thereafter. The primary objective was to determine 6-month overall survival. Secondary end points included progression-free survival, response rate, and toxicity. Tumor tissue was collected for correlative studies. Results: Sixty-three patients were registered, with eight ineligible or never treated. Fifty-five eligible patients (49 men, 6 women; median age = 61.2 years [range, 30.7–88.5]) were enrolled. Twenty patients survived more than 6 months for a 6-month overall survival rate of 36% (95% confidence interval [CI]: 24–50%). The median overall survival was 4.0 months (95% CI: 3.2–5.9). Median progression-free survival was 1.8 months (95% CI: 1.7–1.9). One partial response and two unconfirmed partial responses were observed. Two patients experienced grade 4 fatigue. There was one treatment-related death due to pneumonitis. Germline polymorphisms of epidermal growth factor receptor, epidermal growth factor, interleukin (IL)-8, cyclooxygenase (COX)-2, vascular epidermal growth factor receptor (VEGF), CCND1, neuropilin 1 (NRP1), and K-ras mutational status were not associated with response or survival. Conclusions: The 6-month overall survival rate of 36% observed on this study failed to meet the primary survival objective. Thus, cetuximab alone cannot be recommended in the second-line treatment of metastatic esophageal cancer.
Spelling in Kindergarten: A Constructivist Analysis Comparing Spanish-Speaking and English-Speaking Children.

Abstract The purposes of this study were to find out (1) whether English-speaking American children construct the same developmental levels in spelling as the Spanish-speaking children studied by Ferreiro and Teberosky (1979/1982) and by Ferriero and Gomez Palacio (1982), and (2) whether English-speaking children, too, make their first letter-sound correspondences through syllables. One-hundred ninety-two kindergarten children were individually asked to write eight words such as “punishment,” “cement,” and “pop. ” The developmental levels were found to be similar, but there were some differences between the English-speaking and Spanish-speaking children, especially with respect to the first phoneme-grapheme correspondences they made.
LATE CENOZOIC INCREASE IN ACCUMULATION RATES OF TERRESTRIAL SEDIMENT: How Might Climate Change Have Affected Erosion Rates?

▪ Abstract Accumulation rates of terrestrial sediment have increased in the past few million years both on and adjacent to continents, although not everywhere. Apparently, erosion has increased in elevated terrain regardless of when last tectonically active or what the present-day climate. In many regions, sediment coarsened abruptly in late Pliocene time. Sparser data suggest increased sedimentation rates at ∼15 Ma, approximately when oxygen isotopes in benthic foraminifera imply high-latitude cooling. If climate change effected accelerated erosion, understanding how it did so remains the challenge. Some obvious candidates, such as lowered sea level leading to erosion of continental shelves or increased glaciation, account for increased sedimentation in some, but not all, areas. Perhaps stable climates that varied slowly allowed geomorphic processes to maintain a state of equilibrium with little erosion until ∼3–4 Ma, when large oscillations in climate with periods of 20,000–40,000 years developed and de.
Optimism and pessimism in children: A study of parenting correlates

The present study investigated the relation between mothers’ generalised expectancies, mothers’ self-reported parenting practices, and their children’s optimism, pessimism, and depressive symptoms. A community sample of 81 children, 8–12 years old, and their mothers participated. Questionnaires were used to assess four parenting dimensions (control, structure, support, and autonomy granting), as well as mothers’ and children’s optimism, pessimism, and depressive symptoms. Results showed that maternal pessimism correlated with child pessimism, and that maternal depressive symptoms correlated negatively with child optimism. Multiple regressions indicated that mothers who were moderately controlling had children who showed the most optimism, whereas those who allowed their children little autonomy in problem solving had children with the highest level of depressive symptoms.
How to train your dragon

Imaginary winged creatures in computer animation applications are expected to perform a variety of motor skills in a physically realistic and controllable manner. Designing physics-based controllers for a flying creature is still very challenging particularly when the dynamic model of the creatures is high-dimensional, having many degrees of freedom. In this paper, we present a control method for flying creatures, which are aerodynamically simulated, interactively controllable, and equipped with a variety of motor skills such as soaring, gliding, hovering, and diving. Each motor skill is represented as Deep Neural Networks (DNN) and learned using Deep Q-Learning (DQL). Our control method is example-guided in the sense that it provides the user with direct control over the learning process by allowing the user to specify keyframes of motor skills. Our novel learning algorithm was inspired by evolutionary strategies of Covariance Matrix Adaptation Evolution Strategy (CMA-ES) to improve the convergence rate and the final quality of the control policy. The effectiveness of our Evolutionary DQL method is demonstrated with imaginary winged creatures flying in a physically simulated environment and their motor skills learned automatically from user-provided keyframes.
Relative deprivation and intergroup competition

Two experiments utilized a new experimental paradigm—the Intergroup Prisoner’s Dilemma— Maximizing Difference (IPD-MD) game—to study how relative deprivation at the group level affects intergroup competition. The IPD-MD game enables group members to make a costly contribution to either a within-group pool that benefits fellow ingroup members, or a between-group pool, which, in addition, harms outgroup members. We found that when group members were put in a disadvantaged position, either by previous actions of the outgroup (Experiment 1) or by random misfortune (Experiment 2), they contributed substantially more to the competitive between-group pool. This destructive behavior both minimized inequality between the groups and reduced collective efficiency. Our results underscore the conditions that lead group members to care about relative (rather than absolute) group outcomes and highlight the need to differentiate between the motivation to get ahead and the motivation not to fall behind: the latter, it appears, is what motivates individual participation in destructive intergroup competition.
Joint Channel Estimation and Channel Decoding in Physical-Layer Network Coding Systems: An EM-BP Factor Graph Framework

This paper addresses the problem of joint channel estimation and channel decoding in physical-layer network coding (PNC) systems. In PNC, multiple users transmit to a relay simultaneously. PNC channel decoding is different from conventional multi-user channel decoding: specifically, the PNC relay aims to decode a network-coded message rather than the individual messages of the users. Although prior work has shown that PNC can significantly improve the throughput of a relay network, the improvement is predicated on the availability of accurate channel estimates. Channel estimation in PNC, however, can be particularly challenging because of 1) the overlapped signals of multiple users; 2) the correlations among data symbols induced by channel coding; and 3) time-varying channels. We combine the expectation-maximization (EM) algorithm and belief propagation (BP) algorithm on a unified factor-graph framework to tackle these challenges. In this framework, channel estimation is performed by an EM subgraph, and channel decoding is performed by a BP subgraph that models a virtual encoder matched to the target of PNC channel decoding. Iterative message passing between these two subgraphs allow the optimal solutions for both to be approached progressively. We present extensive simulation results demonstrating the superiority of our PNC receivers over other PNC receivers.
Codes and their vicissitudes

First, we discuss issues raised with respect to the Theory of Event Coding (TEC)'s scope, that is, its limitations and possible extensions. Then, we address the issue of specificity, that is, the widespread concern that TEC is too unspecified and, therefore, too vague in a number of important respects. Finally, we elaborate on our views about TEC's relations to other important frameworks and approaches in the field like stages models, ecological approaches, and the two-visual-pathways model.
Use and misuse of the concept of culture

Culture is an all-pervading construct of human existence but its conceptualization is contested. As such, it is problematic to define or measure culture as different paradigms adopt radically different approaches. Emic approaches are, essentially, inward-looking and, via a constructivist paradigm, assert that a culture can be investigated validly only from that culture’s own perspective (idiographic). Etic approaches are concerned with an outside view, especially for cross-cultural investigations, and so tend to adopt a positivist perspective using surveys, models and dimensions (nomothetic). With increasing acceptance of varying conceptualizations, multiple methodologies and methods of research, founded on alternative philosophical stances, differing approaches to researching culture are pursued. However, several important issues of debate remain and are addressed, especially surrounding the seminal work of Geert Hofstede. Further concerns relate to levels of analyses (notably, the ecological fallacy and its reverse), scales of measurement for data collection and analysis, and their combination into indices. How people adapt to and accommodate different cultures is addressed, including structuring of organizational relationships (alliances, etc.) and the enduring debate over whether culture can be managed and the likely consequences of cultural management endeavours. Thus, the approach of positive criticism is adopted in this review of theory and literature to address the main issues in both the topic of culture and its philosophical underpinnings, and of how research methodologies and methods have been used in researching culture. Aspects of good practice and of less good practice are identified throughout to assist researchers and to stimulate further rigorous research into culture in construction. Primary findings emphasize the imperative of coherent and consistent uses of models and levels of analysis, care and rigour in use of scales and attention to the impacts of language and culture on data from respondents.
Chapter 8: Latent Trait Theories and the Assessment of Educational Achievement

Several more-or-less elementary expositions (Allen & Yen, 1979; Baker, 1977; Gustafsson, 1977; Hambleton, 1979; Hambleton & Cook, 1977; Hashway, 1978; Van den Wollenberg, 1979; Warm, 1978; Wright & Stone, 1979) as well as at least two technically sophisticated treatments (Andersen, 1980b; Lord, 1980a) have appeared during the time since Subkoviak and Baker prepared their review, which was focused on the period from January 1970 to January 1976. Also, several computer programs are now well known and widely available. What is undoubtedly more a consequence of computer program availability than of understanding fostered by the available expositions is the fact that the number of applications of latent trait theory to educational problems has multiplied several times during the past 5 years. As crude evidence of this, we note that at the AERA Annual Meetings of 1975 and 1980 the number of sessions with "latent trait" in their titles was one and nine, respectively. Our assessment of many applications leaves us skeptical, however, that the improved practice hoped for by Subkoviak and Baker has been realized. Many educational researchers, in their eagerness
Living in virtual communities: an ethnography of human relationships in cyberspace

This paper outlines some of the issues involved in the development of human relationships in cyberspace. Set within the wider context of the Internet and society it investigates how geographically distant individuals are coming together on the Internet to inhabit new kinds of social spaces or virtual communities. People ‘live in’ and ‘construct’ these new spaces in such a way as to suggest that the Internet is not a placeless cyberspace that is distinct and separate from the real world. Building on the work of other cyberethnographers, the author combines original ethnographic research in Cybercity, a Virtual Community, with face-to-face meetings to illustrate how, for many people, cyberspace is just another place to meet. Second, she suggests that people in Cybercity are investing as much effort in maintaining relationships in cyberspace as in other social spaces. Her preliminary analysis suggests that by extending traditional human relationships into Cybercity, they are widening their webs of relationships, not weakening them. Human relationships in cyberspace are formed and maintained in similar ways to those in wider society. Rather than being exotic and removed from real life, they are actually being assimilated into everyday life. Furthermore, they are often moved into other social settings, just as they are in offline life.
Presenting Chamber Music to Young Children

The number of professional ensembles and organizations with dedicated outreach concerts has been steadily increasing over the past decade. More recently, educational concerts pairing chamber music with young children have been documented. The work presented in this article is a study in the efficacy and feasibility of this format. Various music activities and ways to engage and involve the audience in performances are presented. The role of the music educator in managing and facilitating the performance is detailed with a subsequent presentation of general guidelines for implementation. Example videos that model music educator—ensemble—audience interaction are included.
Constructing Coherence

In this article, the authors focus on the concept of coherence, a relatively underexplored concept in teacher education. They investigate the relationship between students' perceptions of coherence and a number of structural features of teacher education programs to help develop a stronger definition of one important dimension of coherence—the relationship between fieldwork and coursework. The authors examine the relationship between specific program features and students' perceptions of the degree to which program vision, principles, and practices are aligned with those in the field and also explore the degree to which students have opportunities to practice what they are learning in the program and to enact program goals and visions of good teaching and learning in the classroom. In a field that is calling for larger-scale studies, this research attempts to identify promising features that are also amenable to large-scale studies of the impact of teacher education.
Roles of taurine-mediated tonic GABAA receptor activation in the radial migration of neurons in the fetal mouse cerebral cortex

γ-Aminobutyric acid (GABA) depolarizes embryonic cerebrocortical neurons and continuous activation of the GABAA receptor (GABAAR) contributes to their tonic depolarization. Although multiple reports have demonstrated a role of GABAAR activation in neocortical development, including in migration, most of these studies have used pharmacological blockers. Herein, we performed in utero electroporation in GABA synthesis-lacking homozygous GAD67-GFP knock-in mice (GAD67GFP/GFP) to label neurons born in the ventricular zone. Three days after electroporation, there were no differences in the distribution of labeled cells between the genotypes. The dose–response properties of labeled cells to GABA were equivalent among genotypes. However, continuous blockade of GABAAR with the GABAAR antagonist SR95531 accelerated radial migration. This effect of GABAAR blockade in GAD67GFP/GFP mice suggested a role for alternative endogenous GABAAR agonists. Thus, we tested the role of taurine, which is derived from maternal blood but is abundant in the fetal brain. The taurine-evoked currents in labeled cells were mediated by GABAAR. Taurine uptake was blocked by a taurine transporter inhibitor, 2-(guanidino)ethanesulfonic acid (GES), and taurine release was blocked by a volume-sensitive anion channel blocker, 4-(2-butyl-6,7-dichlor-2-cyclopentylindan-1-on-5-yl) oxobutyric acid, as examined through high-performance liquid chromatography. GES increased the extracellular taurine concentration and induced an inward shift of the holding current, which was reversed by SR95531. In a taurine-deficient mouse model, the GABAAR-mediated tonic currents were greatly reduced, and radial migration was accelerated. As the tonic currents were equivalent among the genotypes of GAD67-GFP knock-in mice, taurine, rather than GABA, might play a major role as an endogenous agonist of embryonic tonic GABAAR conductance, regulating the radial migration of neurons in the developing neocortex.
Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines

Background To improve cancer therapy, it is critical to target metastasizing cells. Circulating tumor cells (CTCs) are rare cells found in the blood of patients with solid tumors and may play a key role in cancer dissemination. Uncovering CTC phenotypes offers a potential avenue to inform treatment. However, CTC transcriptional profiling is limited by leukocyte contamination; an approach to surmount this problem is single cell analysis. Here we demonstrate feasibility of performing high dimensional single CTC profiling, providing early insight into CTC heterogeneity and allowing comparisons to breast cancer cell lines widely used for drug discovery. Methodology/Principal Findings We purified CTCs using the MagSweeper, an immunomagnetic enrichment device that isolates live tumor cells from unfractionated blood. CTCs that met stringent criteria for further analysis were obtained from 70% (14/20) of primary and 70% (21/30) of metastatic breast cancer patients; none were captured from patients with non-epithelial cancer (n = 20) or healthy subjects (n = 25). Microfluidic-based single cell transcriptional profiling of 87 cancer-associated and reference genes showed heterogeneity among individual CTCs, separating them into two major subgroups, based on 31 highly expressed genes. In contrast, single cells from seven breast cancer cell lines were tightly clustered together by sample ID and ER status. CTC profiles were distinct from those of cancer cell lines, questioning the suitability of such lines for drug discovery efforts for late stage cancer therapy. Conclusions/Significance For the first time, we directly measured high dimensional gene expression in individual CTCs without the common practice of pooling such cells. Elevated transcript levels of genes associated with metastasis NPTN, S100A4, S100A9, and with epithelial mesenchymal transition: VIM, TGFß1, ZEB2, FOXC1, CXCR4, were striking compared to cell lines. Our findings demonstrate that profiling CTCs on a cell-by-cell basis is possible and may facilitate the application of ‘liquid biopsies’ to better model drug discovery.
Sex Differences in Empathy and Related Capacities

In this article, the literature on sex differences in empathy (denned as vicarious affective responding to the emotional state of another) and related capacities (affective role taking and decoding of nonverbal cues) was reviewed. The literature was organized and discussed according to method used to assess empathy and affective role taking. Where appropriate, meta-analyses were also computed. In general, sex differences in empathy were a function of the methods used to assess empathy. There was a large sex difference favoring women when the measure of empathy was self-report scales; moderate differences (favoring females) were found for reflexive crying and self-report measures in laboratory situations; and no sex differences were evident when the measure of empathy was either physiological or unobtrusive observations of nonverbal reactions to another's emotional state. Moreover, few sex differences were found for children's affective role taking and decoding abilities. Several possible explanations for the pattern of findings are discussed. Among the characteristics that people attribute more frequently to females than to males is the tendency to empathize. This stereotypic perception has most likely been derived from the broader belief that females are more nurturant and interpersonally oriented than are males—a stereotype that itself is a natural consequence of traditional feminine and masculine roles. Sociological and psychological theorists concerned with social behavior generally have not questioned the veracity of sex-role stereotypes related to empathic reactions. In fact, their conceptualizations are entirely consistent with the notion that females are the more empathic sex. For example, sociologists such as Parsons and Bales (1955) have attributed differences in males' and females' behaviors to variations in the traditional roles of the two sexes. According to Parsons and Bales, in the family unit men typically assume an instrumental role; that is, they serve as a liaison between the family and society and see that the tasks needed for
Disruption of office‐related tasks by speech and office noise

Three experiments examine what is widely reported to be one of the most common forms of interference in open-plan office environments—the effect of background noise. Experiment 1 investigates whether office noise (with or without speech) is disruptive to two office-related tasks: memory for prose and mental arithmetic. The results show that whereas office noise with speech disrupts performance on both tasks, office noise without speech disrupts performance on the mental arithmetic task only. Experiment 2 investigates the memory for prose task more closely by varying the duration and the meaning of the background noise. Experiment 3 examines whether the meaning of speech is important to the disruption of a mental arithmetic task. The results show that both speech and office noise can disrupt performance on memory for prose and mental arithmetic tasks, and the effect is independent of the meaning of the irrelevant speech. These results are presented and interpreted in light of current research and theories regarding the effect of background noise.