Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficiency optimization in linear-assisted switching power converters for envelope tracking in RF power amplifiers

Linear-assisted switchers are based on the idea of combining high efficiency of switching converters with wide-bandwidth capabilities of linear amplifiers. Such linear-assisted switching power converters have been proposed for implementation of wide-bandwidth envelope-tracking power supplies for RF power amplifiers in polar modulation architectures. This paper presents modeling of the overall linear-assisted switcher efficiency as a function of the band separation frequency between the signals processed by the switching and the linear parts. The efficiency model, which is based on the statistical amplitude distributions of the signals, is used to derive the optimum band separation frequency to maximize the overall efficiency. Application examples, including a two-tone test and a CDMA signal in a polar modulation RF transmitter, are presented to illustrate the approach.
Synergy between Enzyme Inhibitors of Fatty Acid Amide Hydrolase and Cyclooxygenase in Visceral Nociception

The present study investigated whether inhibition of fatty acid amide hydrolase (FAAH), the enzyme responsible for anandamide catabolism, produces antinociception in the acetic acid-induced abdominal stretching model of visceral nociception. Genetic deletion or pharmacological inhibition of FAAH reduced acetic acid-induced abdominal stretching. Transgenic mice that express FAAH exclusively in the nervous system displayed the antinociceptive phenotype, indicating the involvement of peripheral fatty acid amides. The cannabinoid receptor 1 (CB1) receptor antagonist, rimonabant, but not the cannabinoid receptor 2 (CB2) receptor antagonist, SR144528, blocked the antinociceptive phenotype of FAAH(-/-) mice and the analgesic effects of URB597 (3′-carbamoyl-biphenyl-3-yl-cyclohexylcarbamate) or OL-135 (1-oxo-1[5-(2-pyridyl)-2-yl]-7-phenyl heptane), respective irreversible and reversible FAAH inhibitors, administered to C57BL/6 mice. The opioid receptor antagonist, naltrexone, did not block the analgesic effects of either FAAH inhibitor. URB597, ED50 [95% confidence interval (CI) = 2.1 (1.5-2.9) mg/kg], and the nonselective cyclooxygenase inhibitor, diclofenac sodium [ED50 (95% CI) = 9.8 (8.2-11.7) mg/kg], dose-dependently inhibited acetic acid-induced abdominal stretching. Combinations of URB597 and diclofenac yielded synergistic analgesic interactions according to isobolographic analysis. It is important that FAAH(-/-) mice and URB597-treated mice displayed significant reductions in the severity of gastric irritation caused by diclofenac. URB597 lost its gastroprotective effects in CB1(-/-) mice, whereas it maintained its efficacy in CB2(-/-) mice, indicating a CB1 mechanism of action. Taken together, the results of the present study suggest that FAAH represents a promising target for the treatment of visceral pain, and a combination of FAAH inhibitors and NSAIDs may have great utility to treat visceral pain, with reduced gastric toxicity.
Differential maturation of avidity of IgG antibodies to gp41, p24 and p17 following infection with HIV‐1

We have evaluated solid‐phase ELISA IgG antibody avidity studies as a means of identifying cases of recent HIV‐1 infection. Although separate studies on the avidity of anti‐gp41 and anti‐p24 antibodies in seroconvertors have been reported, a comparison of the ability of patients to simultaneously mature their immune response to more than one HIV antigen immediately following seroconversion appears to be lacking. We have demonstrated a maturation in anti‐gp41 avidity which reflects the time since seroconversion in all cases. In contrast, however, only some patients produced high‐avidity anti‐p24 or anti‐p17 antibodies during the same time span. While the avidity of anti‐gp41 antibodies remained high in cases of non‐recent HIV infection, even in the face of advanced disease, we have confirmed the findings of others that the avidity of anti‐p24 falls before the onset of ARC or AIDS. Therefore, whilst the avidity of anti‐gp41 antibodies could reliably be of value in identifying cases of recent HIV infection, the avidity of anti‐p24 or anti‐p17 antibodies could not, but may be of prognostic value, even at an early stage. The time taken to reach maximum anti‐p17, anti‐p24 and anti‐gp41 titres was variable, but anti‐gp41 titres, like anti‐gp41 avidity, remained high. In contrast, anti‐p24 titres fell, even during the early follow‐up period in some seroconvertors. Anti‐p24 antibody avidity, however, appeared to be a better predictor of disease progression in ‘remote’ cases than anti‐p24 titre. The avidity and titres of these antibodies are presented in relation to the clinical details, p24 antigen status, CD4 and CD8 counts where these are known.
Home Firm Performance after Foreign Investments and Divestitures

Being international' has nearly become an undisputed aim for firms in a globalized world. Several papers find a positive relationship between foreign direct investment (FDI) and the home performance of firms. In this paper we address the 'FDI - export' relationship to better understand this pattern. Furthermore, by presenting first results on firm's post-divestiture employment growth at home we are able to provide a more comprehensive view on fi rm performance after stepping in and out of foreign markets. We apply a propensity score matching technique in combination with a difference-in-difference estimator to analyze the performance dynamics of French firms that invested abroad or carried out foreign divestitures during the period 2000-2007. FDI has on average a positive home firm eff ect in terms of export share, operating turnover and employment. Industry differences reveal that firms in high-tech industries experience a strong increase in their home performance, whereas firm performance in low-tech industries increases only moderately in post-investment periods. In contrast, the divestiture impact on the post-divestiture performance is rather negligible.
The Essential Yeast Nucleoporin NUP159 Is Located on the Cytoplasmic Side of the Nuclear Pore Complex and Serves in Karyopherin-mediated Binding of Transport Substrate (*)

We have identified a new yeast nucleoporin of 159 kDa that we term NUP159. Immunofluorescence microscopy with a monospecific monoclonal antibody against NUP159 gave the punctate nuclear rim staining characteristic of nucleoporins. Immunogold electron microscopy with isolated yeast NEs yielded decoration of only the cytoplasmic side of the nuclear pore complex. The gene encoding NUP159 is essential, and, like some other nucleoporins, NUP159 contains a coiled-coil domain as well as a domain of repeated motifs. Five segments of NUP159, covering its entire length, were expressed in Escherichia coli. The repeat motif-containing segment was found to bind a nuclear transport substrate in the presence of vertebrate cytosolic extract containing nuclear transport factors. This segment also bound S-labeled mammalian karyopherin β, one such transport factor that mediates the docking of substrates to the nuclear pore complex. These data establish a direct biochemical link between the repeat motif domain of a yeast nucleoporin, transport factors, (specifically karyopherin β), and nuclear transport substrates. Its cytoplasmic aspect implies a role for NUP159 in nuclear import.
Starting Over

Language development is characterized by predictable shifts in the words children produce and the complexity of their utterances. Because acquisition typically occurs simultaneously with maturation and cognitive development, it is difficult to determine the causes of these shifts. We explored how acquisition proceeds in the absence of possible cognitive or maturational roadblocks, by examining the acquisition of English in internationally adopted preschoolers. Like infants, and unlike other second-language learners, these children acquire language from child-directed speech, without access to bilingual informants. Parental reports and speech samples were collected from 27 preschoolers, 3 to 18 months after they were adopted from China. These children showed the same developmental patterns in language production as monolingual infants (matched for vocabulary size). Early on, their vocabularies were dominated by nouns, their utterances were short, and grammatical morphemes were generally omitted. Children at later stages had more diverse vocabularies and produced longer utterances with more grammatical morphemes.
On Partitioning Multivariate Self-Affine Time Series

Given a multivariate time series, possibly of high dimension, with unknown and time-varying joint distribution, it is of interest to be able to completely partition the time series into disjoint, contiguous subseries, each of which has different distributional or pattern attributes from the preceding and succeeding subseries. An additional feature of many time series is that they display self-affinity, so that subseries at one time scale are similar to subseries at another after application of an affine transformation. Such qualities are observed in time series from many disciplines, including biology, medicine, economics, finance, and computer science. This paper defines the relevant multiobjective combinatorial optimization problem with limited assumptions as a biobjective one, and a specialized evolutionary algorithm is presented which finds optimal self-affine time series partitionings with a minimum of choice parameters. The algorithm not only finds partitionings for all possible numbers of partitions given data constraints, but also for self-affinities between these partitionings and some fine-grained partitioning. The resulting set of Pareto-efficient solution sets provides a rich representation of the self-affine properties of a multivariate time series at different locations and time scales.
Responses of primate retinal ganglion cells to perimetric stimuli.

PURPOSE Perimetry is used clinically to assess glaucomatous ganglion cell loss. It has been proposed that frequency-doubling stimuli are better than the conventional size III perimetric stimulus in preferentially stimulating magnocellular (M) versus parvocellular (P) ganglion cells. However, little is known about how primate ganglion cells respond to perimetric stimuli. The authors recorded contrast responses of M and P ganglion cells to size III and frequency-doubling stimuli and compared contrast gain of M and P cells to these stimuli to assess the ability of these stimuli to preferentially stimulate M versus P cells. METHODS Data were recorded from 69 macaque retinal ganglion cells, by an in vivo preparation, at eccentricities of 5° to 15°. The size III stimulus was a circular luminance increment 26 min arc in diameter, 200 ms in duration. The frequency-doubling stimulus was a sinusoidal grating (0.5 cyc/deg) temporally modulated in counterphase at 13 Hz. A Michaelis-Menten function was fit to each cell's contrast responses to assess contrast gain. RESULTS For both size III and frequency-doubling stimuli, ganglion cell responses increased linearly at low contrasts, and then the increase slowed at high contrasts (saturation). The mean (± SE) difference in estimated log contrast gain between M and P cells for the size III stimulus was significantly higher than that for the frequency-doubling stimulus (1.24 ± 0.09 vs. 0.89 ± 0.13; P < 0.01). CONCLUSIONS The size III stimulus was superior to the frequency-doubling stimulus in preferentially stimulating M cells versus P cells.
Extracorporeal Shock Wave Therapy in Musculoskeletal Disorders: A Review

Regenerative therapy is one of the most challenging and intriguing branches of modern medicine. Basic research has demonstrated the effectiveness of extracorporeal shockwaves (ESWT) in stimulating biological activities that involve intra-cell and cell-matrix interactions. These interactions are at the basis of the current clinical applications, and open the horizons to new applications in tissue regeneration. It is also feasible that shock waves could be used to treat various orthopaedic pathologies, removing the need for surgery. However, suitable translational studies need to be performed before ESWT can become a valid alternative to surgery.
Vasopressin excites interneurons to suppress hippocampal network activity across a broad span of brain maturity at birth

Significance The transition from placental to lung-based oxygen supply at mammalian birth involves an obligatory period of asphyxia, which is further aggravated by complications during delivery. This oxygen deprivation is a major threat to the fetal brain, and, under such conditions, hormonal and cardiovascular mechanisms are activated to enhance brain perfusion. Our work now demonstrates an intrinsic mechanism in the fetal brain whereby vasopressin activates hippocampal interneurons, leading to desynchronization and suppression of neuronal network activity in species (rat and guinea pig) that are born at widely different stages of brain maturation. Silencing of synchronous neuronal activity by vasopressin is expected to decrease neuronal energy demand and prevent maladaptive synaptic plasticity, thus acting as a pan-mammalian neuroprotective mechanism during birth. During birth in mammals, a pronounced surge of fetal peripheral stress hormones takes place to promote survival in the transition to the extrauterine environment. However, it is not known whether the hormonal signaling involves central pathways with direct protective effects on the perinatal brain. Here, we show that arginine vasopressin specifically activates interneurons to suppress spontaneous network events in the perinatal hippocampus. Experiments done on the altricial rat and precocial guinea pig neonate demonstrated that the effect of vasopressin is not dependent on the level of maturation (depolarizing vs. hyperpolarizing) of postsynaptic GABAA receptor actions. Thus, the fetal mammalian brain is equipped with an evolutionarily conserved mechanism well-suited to suppress energetically expensive correlated network events under conditions of reduced oxygen supply at birth.
A Developmental Pathway From Early Life Stress to Inflammation

Early life stressors are associated with elevated inflammation, a key physiological risk factor for disease. However, the mechanisms by which early stress leads to inflammation remain largely unknown. Using a longitudinal data set, we examined smoking, alcohol consumption, and body mass index (BMI) as health-behavior pathways by which early adversity might lead to inflammation during young adulthood. Contemporaneously measured early adversity predicted increased BMI and smoking but not alcohol consumption, and these effects were partially accounted for by chronic stress in young adulthood. Higher BMI in turn predicted higher levels of soluble tumor necrosis factor receptor type II (sTNF-RII) and C-reactive protein (CRP), and smoking predicted elevated sTNF-RII. These findings establish that early adversity contributes to inflammation in part through ongoing stress and maladaptive health behavior. Given that maladaptive health behaviors portend inflammation in young adulthood, they serve as promising targets for interventions designed to prevent the negative consequences of early adversity.
A General Framework for Structured Sparsity via Proximal Optimization

We study a generalized framework for structured sparsity. It extends the well known methods of Lasso and Group Lasso by incorporating additional constraints on the variables as part of a convex optimization problem. This framework provides a straightforward way of favouring prescribed sparsity patterns, such as orderings, contiguous regions and overlapping groups, among others. Available optimization methods are limited to specific constraint sets and tend to not scale well with sample size and dimensionality. We propose a first order proximal method, which builds upon results on fixed points and successive approximations. The algorithm can be applied to a general class of conic and norm constraints sets and relies on a proximity operator subproblem which can be computed numerically. Experiments on different regression problems demonstrate state-of-the-art statistical performance, which improves over Lasso, Group Lasso and StructOMP. They also demonstrate the efficiency of the optimization algorithm and its scalability with the size of the problem.
The Proapoptotic Bcl-2 Protein Bax Plays an Important Role in the Pathogenesis of Reovirus Encephalitis

ABSTRACT Encephalitis induced by reovirus serotype 3 (T3) strains results from the apoptotic death of infected neurons. Extrinsic apoptotic signaling is activated in reovirus-infected neurons in vitro and in vivo, but the role of intrinsic apoptosis signaling during encephalitis is largely unknown. Bax plays a key role in intrinsic apoptotic signaling in neurons by allowing the release of mitochondrial cytochrome c. We found Bax activation and cytochrome c release in neurons following infection of neonatal mice with T3 reoviruses. Bax−/− mice infected with T3 Abney (T3A) have reduced central nervous system (CNS) tissue injury and decreased apoptosis, despite viral replication that is similar to that in wild-type (WT) Bax+/+ mice. In contrast, in the heart, T3A-infected Bax−/− mice have viral growth, caspase activation, and injury comparable to those in WT mice, indicating that the role of Bax in pathogenesis is organ specific. Nonmyocarditic T3 Dearing (T3D)-infected Bax−/− mice had delayed disease and enhanced survival compared to WT mice. T3D-infected Bax−/− mice had significantly lower viral titers and levels of activated caspase 3 in the brain despite unaffected transneuronal spread of virus. Cytochrome c and Smac release occurred in some reovirus-infected neurons in the absence of Bax; however, this was clearly reduced compared to levels seen in Bax+/+ wild-type mice, indicating that Bax is necessary for efficient activation of proapoptotic mitochondrial signaling in infected neurons. Our studies suggest that Bax is important for reovirus growth and pathogenesis in neurons and that the intrinsic pathway of apoptosis, mediated by Bax, is important for full expression of disease, CNS tissue injury, apoptosis, and viral growth in the CNS of reovirus-infected mice.
Epidemiologic Characteristics of Death by Poisoning in 1991-2001 in Korea

The purpose of this study was to investigate the epidemiologic characteristics of the death by poisoning in Korea. We recoded the Death Certificates Database by injury based on the short version of the International Classification of External Causes of Injuries (ICECI). We evaluated the mortality rate by total injury and poisoning, and analyzed the mortality rate by age, gender, year and month, toxic agent, and intent. Adjusted odds ratios were calculated to evaluate the effects of socioeconomic factors on suicidal poisoning death. The total number of death cases by injury was 346,656. The proportion of death cases by injury decreased from 13.53% of all death cases in 1991 to 11.89% in 2001. However, the mortality rate by poisoning increased rapidly from 1998, and then remained stable. The number of suicidal poisoning deaths has gradually increased, and its mortality rate was 6.41 (per 100,000) in 2001. Major toxic agents were pesticides and herbicides (50.90%) in 2001. Adjusted odds ratios of suicidal poisoning versus other poisonings showed significant differences in education attainment, region, and marital status. In conclusion, the mortality rate by poisoning has increased, and the proportion of suicidal poisoning also has increased compared to that of accidental poisoning.
Relation between the Rational Model and the Context Model of Categorization

A formal proof is provided that Anderson's (1990) rational model of categorization generalizes the Medin and Schaffer (1978) context model. According to the context model, people represent categories by storing individual exemplars in memory. According to the rational model, people represent categories in terms of multiple exemplar-clusters or prototypes. In both models, a multiplicative rule is used to compute the similarity of an item to the underlying category representations. In certain special cases, each multiple prototype in the rational model corresponds to an individual exemplar, and in these cases the rational model reduces to the context model. Preliminary quantitative comparisons between the models are illustrated to test whether the multiple-prototype view adds significant explanatory power over the pure exemplar view.
Effect of Dietary Marine Microalgae (Schizochytrium) Powder on Egg Production, Blood Lipid Profiles, Egg Quality, and Fatty Acid Composition of Egg Yolk in Layers

Two hundred and sixteen Institut de Sélection Animale (ISA) brown layers (40 wks of age) were studied for 6 wks to examine the effect of microalgae powder (MAP) on egg production, egg quality, blood lipid profile, and fatty acid concentration of egg yolk. Dietary treatments were as follows: i) CON (basal diet), ii) 0.5% MAP (CON+0.5% Schizochytrium powder), and iii) 1.0% MAP (CON+1.0% Schizochytrium powder). From 44 to 46 wks, egg production was higher in 1.0% MAP treatment than in control treatment (linear, p = 0.034); however, there was no difference on the egg production from 40 to 43 wks (p>0.05). Serum triglyceride and total cholesterol were significantly reduced in the groups fed with MAP, compared to those in groups fed with control diets (Quadratic, p = 0.034 and p = 0.039, respectively). Inclusion of 0.5% MAP in the diet of layers improved egg yolk color, compared with hens fed with basal diet at 46 wks (quadratic, p = 0.044). Eggshell thickness was linearly increased in MAP-fed treatments at 46th wk (p<0.05). Concentration of yolk docosahexaenoic acid (DHA; C22:6n-3) was increased in treatment groups fed with MAP (linear, p<0.05). The n-6 fatty acids, n-6/n-3 fatty acid, and unsaturated fatty acid/saturated fatty acid were decreased in treatment groups fed with MAP (linear, p<0.05). These results suggest that MAP improved the egg production and egg quality, and may affect serum lipid metabolites in the layers. In addition, MAP increases yolk DHA levels, and deceases n-6/n-3 fatty acid ratio.
High-Order Pattern Discovery from Discrete-Valued Data

To uncover qualitative and quantitative patterns in a data set is a challenging task for research in the area of machine learning and data analysis. Due to the complexity of real-world data, high-order (polythetic) patterns or event associations, in addition to first-order class-dependent relationships, have to be acquired. Once the patterns of different orders are found, they should be represented in a form appropriate for further analysis and interpretation. The authors propose a novel method to discover qualitative and quantitative patterns (or event associations) inherent in a data set. It uses the adjusted residual analysis in statistics to test the significance of the occurrence of a pattern candidate against its expectation. To avoid exhaustive search of all possible combinations of primary events, techniques of eliminating the impossible pattern candidates are developed. The detected patterns of different orders are then represented in an attributed hypergraph which is lucid for pattern interpretation and analysis. Test results on artificial and real-world data are discussed toward the end of the paper.
Angular asymmetries as a probe for anomalous contributions to HZZ vertex at the LHC

In this article, the prospects for studying the tensor structure of the $HZZ$ vertex with the LHC experiments are presented. The structure of tensor couplings in Higgs di-boson decays is investigated by measuring the asymmetries and by studying the shapes of the final state angular distributions. The expected background contributions, detector resolution, and trigger and selection efficiencies are taken into account. The potential of the LHC experiments to discover sizeable non-Standard Model contributions to the $HZZ$ vertex with 300 and $3000\text{ }\text{ }{\mathrm{fb}}^{\ensuremath{-}1}$ is demonstrated.