Miracle-dz/UniFAR-FTUs huggingface dataset:
Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women.

AIMS To determine whether peri-coronary epicardial adipose tissue (EAT) is associated with vascular risk factors and coronary atherosclerosis. METHODS AND RESULTS In this study, 573 healthy post-menopausal women underwent a cardiac CT scan to assess coronary calcification. Peri-coronary EAT thickness was measured in the areas of right coronary artery (RCA), left anterior descending (LAD) artery, and left circumflex (LCX) coronary artery. Average EAT thickness was 16.5 +/- 4.3 mm (range 5.9-34.6) in the RCA area, 6.4 +/- 2.2 mm (range 2.0-14.0) in the LAD area, and 10.8 +/- 3.0 mm (range 2.8-29.1) in the LCX area. Overall average thickness was 11.2 +/- 2.2 mm (range 5.4-19.1). EAT was positively related to age (P = 0.002). In age-adjusted linear regression models, EAT was positively related to weight (P< 0.001), waist circumference (P< 0.001), waist-to-hip ratio (P< 0.001), body mass index (P< 0.001), glucose (P< 0.001), triglycerides (P = 0.001), use of anti-hypertensive drugs (P = 0.007), and systolic blood pressure (P = 0.034), and inversely to HDL cholesterol (P = 0.005). In multivariable models, age, weight, waist circumference, smoking, and glucose were the main determinants of EAT. EAT showed a graded relation with coronary calcification (P = 0.026). CONCLUSION EAT is strongly related to vascular risk factors and coronary calcification. Our findings support the hypothesis that EAT affects coronary atherosclerosis and possibly coronary risk.
Structural requirements for membrane assembly of proteins spanning the membrane several times

We have investigated the structural requirements for the biogenesis of proteins spanning the membrane several times. Proteins containing various combinations of topological signals (signal anchor and stop transfer sequences) were synthesized in a cell-free translation system and their membrane topology was determined. Proteins spanning the membrane twice were obtained when a signal anchor sequence was followed by either a stop transfer sequence or a second signal anchor sequence. Thus, a signal anchor sequence in the second position can function as a stop transfer sequence, spanning the membrane in the opposite orientation to that of the first signal anchor sequence. A signal anchor sequence in the third position was able to insert amino acid sequences located COOH terminal to it. We conclude that proteins spanning the membrane several times can be generated by stringing together signal anchor and stop transfer sequences. However, not all proteins with three topological signals were found to span the membrane three times. A certain segment located between the first and second topological signal could prevent stable membrane integration of a third signal anchor segment.
Middle school band students’ self-determination to practice

The purposes of this study were to examine factors that motivate middle school band students to practice their instrument and to validate a researcher-modified survey instrument for use with middle school music students, using self-determination theory as a theoretical lens. Fifth (10–11 years old, n = 444) and eighth grade (13–14 years old, n = 352) band students from the state of Ohio, United States’ public school districts completed a researcher-modified questionnaire that was used to collect data to determine (a) students’ levels of self-determination for practicing their instrument, (b) the relationship between students’ self-determination for practicing their instrument and the number of years they have played their instrument, (c) the relationship between students’ self-determination for practicing their instrument and the amount of time they reported practicing their instrument per week, and (d) the effect of grade level, gender, instrument choice, and private lesson study on the students’ self-determination for practicing their instrument. Positive significant relationships (p < .05) were found between middle school band student participants’ motivation to practice and (a) their years of experience playing their instrument, and (b) the amount of time spent practicing. Significant differences were also found for the variables (a) grade level for six of the seven self-determination subscales, (b) gender for two intrinsic and one extrinsic motivation subscales, (c) instrument for one intrinsic, two extrinsic, and the amotivation subscales, and (d) private lesson study for one intrinsic motivation and the amotivation subscales.
Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4

Purpose Autosomal dominant Stargardt disease-3 (STGD3) is caused by mutations in elongase of very long chain fatty acids-4 (ELOVL4). The goal of this study was to generate and characterize heterozygous and homozygous knockin-mice that carry a human STGD3 pathogenic mutation in the mouse Elovl4 gene. Methods Recombinant Stgd3-knockin mice were generated using a DNA construct which introduced a pathogenic five-base pair deletion and two point mutations in exon 6 of the Elovl4 gene. Stgd3-mouse genotypes were confirmed by Southern blot analysis and expression of wild-type (wt) and mutated Elovl4 mRNAs assayed by nuclease protection assay. The retinal phenotype of heterozygous Stgd3 mice was characterized by morphological studies, elecroretinographic (ERG) analysis and assay of lipofuscin accumulation. Homozygous Stgd3 mice were examined for both retinal and gross morphology. They were also analyzed for skin morphology and skin barrier function, and for epidermal lipid content using high performance liquid chromatography (HPLC) combined with mass spectrometry (MS). Results The Stgd3 allele codes for a truncated mouse Elovl4 protein, which also contains the same aberrant 8-amino acid C-terminus encoded by the human pathogenic STGD3 allele. Heterozygous Stgd3 mice expressed equal amounts of both wt and mutant Elovl4 mRNAs in the retina, showed no significant changes in retinal morphology, but did show accumulation of lipofuscin and reduced visual function. Homozygous Stgd3 mice were born with an expected Mendelian frequency, without any initial gross anatomical or behavioral abnormalities. By 6-12 h postpartum, they became dehydrated and died. A skin permeability assay detected a defect in epidermal barrier function. Homozygous mutant epidermis expressed a normal content of mutated Elovl4 mRNA and contained all four epidermal cellular layers. HPLC/MS analysis of epidermal lipids revealed the presence of all barrier lipids with the exception of the complete absence of acylceramides, the critical lipids for barrier function of the skin. Conclusions The generated Stgd3-knockin mice are a genetic model of human STGD3 and reproduce features of the human disease: accumulation of lipofuscin and reduced visual functions. Homozygous Stgd3 mice showed a complete absence of acylceramides from the epidermis. Their absence suggests a role for Elovl4 in acylceramide synthesis, and in particular, a role in the synthesis of the unique very long chain C30-C40 fatty acids present in skin acylceramides.
HSV-1 gM and the gK/pUL20 Complex Are Important for the Localization of gD and gH/L to Viral Assembly Sites

Herpes simplex virus-1 (HSV-1), like all herpesviruses, is a large complex DNA virus containing up to 16 different viral membrane proteins in its envelope. The assembly of HSV-1 particles occurs by budding/wrapping at intracellular membranes producing infectious virions contained within the lumen of cytoplasmic membrane-bound compartments that are then released by secretion. To ensure incorporation of all viral membrane proteins into the envelope, they need to be localized to the appropriate intracellular membranes either via the endocytic pathway or by direct targeting to assembly sites from the biosynthetic secretory pathway. Many HSV-1 envelope proteins encode targeting motifs that direct their endocytosis and targeting, while others do not, including the essential entry proteins gD and the gH/gL complex, and so it has been unclear how these envelope proteins reach the appropriate assembly compartments. We now show that efficient endocytosis of gD and gH/gL and their incorporation into mature virions relies upon the presence of the HSV-1 envelope proteins gM and the gK/pUL20 complex. Our data demonstrate both redundant and synergistic roles for gM and gK/pUL20 in controlling the targeting of gD and gH/L to the appropriate intracellular virus assembly compartments.
What is Involved and What is Necessary for Complex Linguistic and Nonlinguistic Auditory Processing: Evidence from Functional Magnetic Resonance Imaging and Lesion Data

We used functional magnetic resonance imaging (fMRI) in conjunction with a voxel-based approach to lesion symptom mapping to quantitatively evaluate the similarities and differences between brain areas involved in language and environmental sound comprehension. In general, we found that language and environmental sounds recruit highly overlapping cortical regions, with cross-domain differences being graded rather than absolute. Within language-based regions of interest, we found that in the left hemisphere, language and environmental sound stimuli evoked very similar volumes of activation, whereas in the right hemisphere, there was greater activation for environmental sound stimuli. Finally, lesion symptom maps of aphasic patients based on environmental sounds or linguistic deficits [Saygin, A. P., Dick, F. , Wilson, S. W. , Dronkers, N. F. , & Bates, E. Shared neural resources for processing language and environmental sounds: Evidence from aphasia. Brain, 126, 928945, 2003] were generally predictive of the extent of blood oxygenation level dependent fMRI activation across these regions for sounds and linguistic stimuli in young healthy subjects.
Cost of Illness of Multiple Sclerosis - A Systematic Review

Background Cost-of-illness (COI) studies of Multiple Sclerosis (MS) are vital components for describing the economic burden of MS, and are frequently used in model studies of interventions of MS. We conducted a systematic review of studies estimating the COI of MS, to compare costs between studies and examine cost drivers, emphasizing generalizability and methodological choices. Material and method A literature search on studies published in English on COI of MS was performed in PubMed for the period January 1969 to January 2014, resulting in 1,326 publications. A mapping of studies using a bottom-up approach or top-down approach, respectively, was conducted for the 48 studies assessed as relevant. In a second analysis, the cost estimates were compared between the 29 studies that used a societal perspective on costs, human capital approach for indirect costs, presenting number of patients included, time-period studied, and year of price level used. Results The mapping showed that bottom-up studies and prevalence approaches were most common. The cost ratios between different severity levels within studies were relatively stable, to the ratio of 1 to 2 to 3 for disability level categories. Drugs were the main cost drivers for MS-patients with low disease severity, representing 29% to 82% of all costs in this patient group, while the main cost components for groups with more advanced MS symptoms were production losses due to MS and informal care, together representing 17% to 67% of costs in those groups. Conclusion The bottom-up method and prevalence approach dominated in studies of COI of MS. Our findings show that there are difficulties in comparing absolute costs across studies, nevertheless, the relative costs expressed as cost ratios, comparing different severity levels, showed higher resemblance. Costs of drugs were main cost drivers for less severe MS and informal care and production losses for the most severe MS.
Energy-Efﬁcient Resource Allocation for Mobile-Edge Computation Ofﬂoading

Mobile-edge computation ofﬂoading (MECO) ofﬂoads intensive mobile computation to clouds located at the edges of cellular networks. Thereby, MECO is envisioned as a promising technique for prolonging the battery lives and enhancing the computation capacities of mobiles. In this paper, we study resource allocation for a multiuser MECO system based on time-division multiple access (TDMA) and orthogonal frequency-division multiple access (OFDMA). First, for the TDMA MECO system with inﬁnite or ﬁnite computation capacity, the optimal resource allocation is formulated as a convex optimization problem for minimizing the weighted sum mobile energy consumption under the constraint on computation latency. The optimal policy is proved to have a threshold-based structure with respect to a derived ofﬂoading priority function , which yields priorities for users according to their channel gains and local computing energy consumption. As a result, users with priorities above and below a given threshold perform complete and minimum ofﬂoading, respectively. Moreover, for the cloud with ﬁnite capacity, a sub-optimal resource-allocation algorithm is proposed to reduce the computation complexity for computing the threshold. Next, we consider the OFDMA MECO system, for which the optimal resource allocation is formulated as a non-convex mixed-integer problem. To solve this challenging problem and characterize its policy structure, a sub-optimal low-complexity algorithm is proposed by transforming the OFDMA problem to its TDMA counterpart. The corresponding resource allocation is derived by deﬁning an average ofﬂoading priority function and shown to have close-to-optimal performance in simulation.
Spectroscopic diagnostic for the mineralogy of large dust grains

We examine the thermal infrared spectra of large dust grains composed of amorphous and crystalline olivine. Strong resonances in the refractive indices result in detectable spectral structure even when the grain is much larger than the wavelength at which it radiates. We apply this to the thermal infrared spectra of compact amorphous and crystalline silicates. The weak resonances of amorphous silicates at 9.7 and 18 mum virtually disappear for grains larger than about 10 mum. In contrast, the strong resonances of crystalline silicates produce emission dips in the infrared spectra of large grains; these emission dips are shifted in wavelength compared to the emission peaks commonly seen in small crystalline silicate grains. We discuss the effect of a fluffy or compact grain structure on the infrared emission spectra of large grains, and apply our results to the dust shell surrounding Vega.
Deficits, Gifts, and Bequests: Ricardian Equivalence Revisited

This paper studies deviations from Ricardian equivalence for deficit-financed tax cuts of various durations in an incomplete-markets overlapping-generations (OLG) economy with imperfect altruism. The novel feature is that generations’ degrees of altruism are calibrated to aggregate data on inter-vivos transfers. The results of this economy are contrasted with two workhorse models, a dynastic economy and a standard OLG economy, both of which make strong implicit assumptions on altruism. Deviations from Ricardian equivalence in the imperfectaltruism economy are even larger than those in the standard OLG economy, welfare implications, however, tend to be closer to the dynastic economy. JEL
Expansion of vegetated coastal ecosystems in the future Arctic

Warming occurs particularly fast in the Arctic and exerts profound effects on arctic ecosystems. Sea ice-associated ecosystems are projected to decline but reduced arctic sea ice cover also increases the solar radiation reaching the coastal seafloors with the potential for expansion of vegetated habitats, i.e. kelp forests and seagrass meadows. These habitats support key ecosystem functions, some of which may mitigate effects of climate change. Therefore, the likely expansion of vegetated coastal habitats in the Arctic will generate new productive ecosystems, offer habitat for a number of invertebrate and vertebrate species, including provision of refugia for calcifiers from possible threats from ocean acidification, contribute to enhance CO2 sequestration and protect the shoreline from erosion. The development of models allowing quantitative forecasts of the future of vegetated arctic ecosystems requires that key hypotheses underlying such forecasts be tested. Here we propose a set of three key testable hypotheses along with a research agenda for testing them using a broad diversity of approaches, including analyses of paleo-records, space for-time substitutions and experimental studies. The research agenda proposed would provide a solid underpinning to guide forecasts on the spread of marine macrophytes onto the Arctic with climate change and contribute to balance our understanding of climate change impacts on the arctic ecosystem through a focus on the role of engineering species. Anticipating these changes in ecosystem structure and function is key to develop managerial strategies to maximize these ecosystem services in a future warmer Arctic.
Metaphor Comprehension and Interpretation in Cleft Palate Children Aged 6–9

Abstract The level of metaphor comprehension and interpretation was investigated in a sample of children with cleft palate (CP), aged 6;0-8;11, and healthy controls matched with age, sex, socioeconomic status, and IQ level. The Wechsler Intelligence Scale for Children - Revised (WISC-R) was used to evaluate the children’s cognitive functioning, and the metaphor tests from a modified version of the Right Hemisphere Language Battery - Polish version (RHLB-PL) were used to assess comprehension of figurative language. The CP and control groups differed significantly in Verbal IQ values and in performance in the Vocabulary test, Comprehension test, Picture Metaphor Explanation test, and Written Metaphor Explanation test. In both metaphor explanation tests, children with CP gave fewer responses than controls. The results suggest no differences between children with CP and controls in understanding figurative language, although they point to weaker performance in communicating responses and producing statements in the CP children group.
Oscillations and Chaos in Simple Quadratic Systems

This paper is concerned with the study of third order quadratic and autonomous systems and the interest is oriented to the stable periodic oscillations. From the "jerk" equation model, the classes of minimal complexity presenting a Hopf bifurcation are derived and their local characterization is carried out by means of a suitable harmonic balance technique. Other possible system reductions preserving the oscillations are studied and the numerical analysis confirms the obtained results. Some bifurcations and related routes to chaos are also exhibited by these simple systems. A comparison with previous results on the subject is also presented.
Novel Chemoautotrophic Endosymbiosis between a Member of the Epsilonproteobacteria and the Hydrothermal-Vent Gastropod Alviniconcha aff. hessleri (Gastropoda: Provannidae) from the Indian Ocean

ABSTRACT The hydrothermal-vent gastropod Alviniconcha aff. hessleri from the Kairei hydrothermal field on the Central Indian Ridge houses bacterium-like cells internally in its greatly enlarged gill. A single 16S rRNA gene sequence was obtained from the DNA extract of the gill, and phylogenetic analysis placed the source organism within a lineage of the epsilon subdivision of the Proteobacteria. Fluorescence in situ hybridization analysis with an oligonucleotide probe targeting the specific epsilonproteobacterial subgroup showed the bacterium densely colonizing the gill filaments. Carbon isotopic homogeneity among the gastropod tissue parts, regardless of the abundance of the endosymbiont cells, suggests that the carbon isotopic composition of the endosymbiont biomass is approximately the same as that of the gastropod. Compound-specific carbon isotopic analysis revealed that fatty acids from the gastropod tissues are all 13C enriched relative to the gastropod biomass and that the monounsaturated C16 fatty acid that originates from the endosymbiont is as 13C enriched relative to the gastropod biomass as that of the epsilonproteobacterial cultures grown under chemoautotrophic conditions. This fractionation pattern is most likely due to chemoautotrophy based on the reductive tricarboxylic-acid (rTCA) cycle and subsequent fatty acid biosynthesis from 13C-enriched acetyl coenzyme A. Enzymatic characterization revealed evident activity of several key enzymes of the rTCA cycle, as well as the absence of ribulose-1,5-bisphosphate carboxylase/oxygenase activity in the gill tissue. The results from anatomic, molecular phylogenetic, bulk and compound-specific carbon isotopic, and enzymatic analyses all support the inference that a novel nutritional strategy relying on chemoautotrophy in the epsilonproteobacterial endosymbiont is utilized by the hydrothermal-vent gastropod from the Indian Ocean. The discrepancies between the data of the present study and those of previous ones for Alviniconcha gastropods from the Pacific Ocean imply that at least two lineages of chemoautotrophic bacteria, phylogenetically distinct at the subdivision level, occur as the primary endosymbiont in one host animal type.
Integrative pharmacogenomics to infer large-scale drug taxonomy

Identification of drug targets and mechanism of action (MoA) for new and uncharacterlzed drugs is important for optimization of drug efficacy. Current MoA prediction approaches largely rely on prior information including side effects, therapeutic indication and/or chemo-informatics. Such information is not transferable or applicable for newly identified, previously uncharacterlzed small molecules. Therefore, a shift in the paradigm of MoA predictions is necessary towards development of unbiased approaches that can elucidate drug relationships and efficiently classify new compounds with basic input data. We propose a new integrative computational pharmacogenomlc approach, referred to as Drug Network Fusion (DNF), to infer scalable drug taxonomies that relies only on basic drug characteristics towards elucidating drug-drug relationships. DNF is the first framework to integrate drug structural information, high-throughput drug perturbation and drug sensitivity profiles, enabling drug classification of new experimental compounds with minimal prior information. We demonstrate that the DNF taxonomy succeeds in identifying pertinent and novel drug-drug relationships, making it suitable for investigating experimental drugs with potential new targets or MoA. We highlight how the scalability of DNF facilitates identification of key drug relationships across different drug categories, and poses as a flexible tool for potential clinical applications in precision medicine. Our results support DNF as a valuable resource to the cancer research community by providing new hypotheses on the compound MoA and potential insights for drug repurposlng.
Semantic distance in WordNet: An experimental, application-oriented evaluation of five measures

Five different proposed measures of similarity or semantic distance in WordNet were experimentally compared by examining their performance in a real-word spelling correction system. It was found that Jiang and Con-rath’s measure gave the best results overall. That of Hirst and St-Onge seriously over-related, that of Resnik seriously under-related, and those of Lin and of Leacock and Chodorow fell in between.