Miracle-dz/UniFAR-FTUs huggingface dataset:
Neocortical Long-Term Potentiation and Experience-Dependent Synaptic Plasticity Require α-Calcium/Calmodulin-Dependent Protein Kinase II Autophosphorylation

Experience-dependent plasticity can be induced in the barrel cortex by removing all but one whisker, leading to potentiation of the neuronal response to the spared whisker. To determine whether this form of potentiation depends on synaptic plasticity, we studied long-term potentiation (LTP) and sensory-evoked potentials in the barrel cortex of α-calcium/calmodulin-dependent protein kinase II (αCaMKII)T286A mutant mice. We studied three different forms of LTP induction: theta-burst stimulation, spike pairing, and postsynaptic depolarization paired with low-frequency presynaptic stimulation. None of these protocols produced LTP in αCaMKIIT286A mutant mice, although all three were successful in wild-type mice. To study synaptic plasticity in vivo, we measured sensory-evoked potentials in the barrel cortex and found that single-whisker experience selectively potentiated synaptic responses evoked by sensory stimulation of the spared whisker in wild types but not in αCaMKIIT286A mice. These results demonstrate that αCaMKII autophosphorylation is required for synaptic plasticity in the neocortex, whether induced by a variety of LTP induction paradigms or by manipulation of sensory experience, thereby strengthening the case that the two forms of plasticity are related.
Learning and Visceral Temptation in Dynamic Savings Experiments

This paper tests two explanations for apparent undersaving in life cycle models: bounded rationality and a preference for immediacy. Each was addressed in a separate experimental study. In the first study, subjects saved too little initially—providing evidence for bounded rationality—but learned to save optimally within four repeated life cycles. In the second study, thirsty subjects who consume beverage sips immediately, rather than with a delay, show greater relative overspending, consistent with quasi-hyperbolic discounting models. The parameter estimates of overspending obtained from the second study, but not the first, are in range of several empirical studies of saving (with an estimated β = 0.6–0.7). (This abstract was borrowed from another version of this item.)
Glucose-Related Dissociation between icaADBC Transcription and Biofilm Expression by Staphylococcus epidermidis: Evidence for an Additional Factor Required for Polysaccharide Intercellular Adhesin Synthesis

ABSTRACT Biofilm formation in Staphylococcus epidermidis depends, in the majority of the strains, on the activity of the icaADBC locus. The expression of the operon that encodes the synthetic enzymes of the intercellular polysaccharide adhesin (PIA) depends on a variety of exogenic environmental conditions and is, at least in part, regulated by the alternative sigma factor σB. We investigated the transcriptional regulation of the ica operon and the respective phenotypes expressed under growth conditions differing in the content of glucose in the growth medium. In the presence of glucose, S. epidermidis exhibited a PIA- and biofilm-positive phenotype whereas ica transcription was down-regulated in the postexponential and stationary phases of growth. Surprisingly, maximum transcription of ica was detectable in the stationary phase of growth in the absence of glucose despite the expression of a PIA- and biofilm-negative phenotype. In vitro enzymatic assays and phenotypic characterization showed that the abundant amount of ica mRNA was functionally active because induction of stationary-phase cells with glucose led to immediate PIA synthesis. Induction of biofilm formation could be completely inhibited by chloramphenicol, which, given at a later stage of biofilm accumulation, also inhibited further development of preformed biofilm, indicating that continuous translation of an additional, icaADBC-independent factor is required for the expression of a biofilm-positive phenotype.
Turning the inside out: Social media and the broadcasting of indigenous discourse

This article analyses what happens on social media (Twitter) when a local issue specific to a certain Indigenous group spreads out to a wider network of actors. We look closer at the process where emic (inside) discourses are enabled, through social media, to reach a broader audience and become part of translocal debates. In a case study of information sharing, network building and support on Twitter in relation to a series of Sámi anti-mining protests in 2013, we address questions about the dynamics, flows and process of Indigenous communication on Twitter. First, we analyse in what ways and to what extent the posts are used for inreach communication or outreach communication. Second, we analyse the role of tweets that contain links to web resources for broadcasting Indigenous concerns to a wider, more diverse audience. Finally, we assess how different types of actors interact in order to shape the circulation of content. Our analysis shows even though communication went beyond the core community, Sámi actors still appeared to own and control the discourse and agenda on the issue in social media. Obviously, online communities are not secluded communities. For geographically localized groups and for marginalized communities, the use of global social media does not only enable communication with actors in more distant groups and places; social media also makes visible common interests and goals on a global scale. The possibility of addressing multiple audiences at the same time increases the potential of reaching an audience outside one’s set of ‘followers’ or one’s tight-knit communities of like-minded people.
Sea‐ice deformation rates from satellite measurements and in a model

Abstract The deformation of sea ice is an important element of the Arctic climate system because of its influence on the ice‐thickness distribution and on the rates of ice production and melt. New data obtained from the Radarsat Geophysical Processor System (RGPS) using satellite synthetic aperture radar images of the ice offers an opportunity to compare observations of the ice deformation to estimates obtained from models. The RGPS tracks tens of thousands of points, spaced roughly at 10‐km intervals, for an entire season in a Lagrangian fashion. The deformation is computed from cells formed by the tracked points, typically at 3‐day intervals. We used a coupled ice/ocean model with ice‐thickness and enthalpy distributions that covers the entire Arctic Ocean with a 40‐km grid. Model‐only and model‐with‐data‐assimilation runs were analysed. The data assimilation runs were analysed in order to determine the validity of the comparison techniques and to find the comparisons under the best of circumstances, when many buoy measurements are available for assimilation. This step is necessary because the RGPS and model data differ in spatial and temporal sampling characteristics. The assimilated data included buoy motion and Special Sensor Microwave/Imager (SSM/I)‐derived ice motion. The Pacific half of the Arctic Basin was analysed for a 10‐month period in 1997 and 1998. Comparisons of ice velocity observations to the modelled velocities showed excellent agreement from the model‐with‐data‐assimilation run but poorer agreement for the model‐only run. At a scale of 320 km, the deformation from the data assimilation run was in modest agreement with the observations but where many buoys were available for assimilation the agreement was quite good. Both model runs showed poor agreement during summer. Comparisons of the deformation distribution functions suggest why the agreements were poor even though the velocity agreements were good. Decreasing the ice strength parameter in the model improved the deformation comparisons for the model‐only runs.
PREFERENCE FORMATION

■ Abstract This review concerns political preferences—what they are and where they come from. We begin by documenting the close relationship between processes of preference formation and change. Rather than suddenly appearing, most preferences emerge from interactions between individuals and their environment. This aspect of preference formation poses a concrete challenge: to uncover the mechanics of these interactions in important social contexts. We then describe political science research that meets this challenge. We find an expansive literature that clarifies how phenomena such as parties, campaigns, and the need to act strategically affect preferences. This work provides many widely applicable insights.
An Introduction to Milner ’ s CCS

These notes are intended to support the course on Semantics and Verification, and may be read independently or in conjuction with Milner’s textbook [12]. They are under constant revision, and their most recent version is available at the URL http://www.cs. auc.dk/∼luca/SV/intro2ccs.pdf. Please let us know of any comment you may have, or typographical mistake you may find, by sending an email at the addresses luca@cs.aau. dk and srba@cs.aau. dk with subject line “CCS Notes”.
The serum matrix metalloproteinase-9 level is an independent predictor of recurrence after ablation of persistent atrial fibrillation

OBJECTIVES: This study investigated whether the serum matrix metalloproteinase-9 level is an independent predictor of recurrence after catheter ablation for persistent atrial fibrillation. METHODS: Fifty-eight consecutive patients with persistent atrial fibrillation were enrolled and underwent catheter ablation. The serum matrix metalloproteinase-9 level was detected before ablation and its relationship with recurrent arrhythmia was analyzed at the end of the follow-up. RESULTS: After a mean follow-up of 12.1±7.2 months, 21 (36.2%) patients had a recurrence of their arrhythmia after catheter ablation. At baseline, the matrix metalloproteinase-9 level was higher in the patients with recurrence than in the non-recurrent group (305.77±88.90 vs 234.41±93.36 ng/ml, respectively, p=0.006). A multivariate analysis showed that the matrix metalloproteinase-9 level was an independent predictor of arrhythmia recurrence, as was a history of atrial fibrillation and the diameter of the left atrium. CONCLUSION: The serum matrix metalloproteinase-9 level is an independent predictor of recurrent arrhythmia after catheter ablation in patients with persistent atrial fibrillation.
Lifetime Risk Factors and Arterial Pulse Wave Velocity in Adulthood: The Cardiovascular Risk in Young Finns Study

Limited and partly controversial data are available regarding the relationship of arterial pulse wave velocity and childhood cardiovascular risk factors. We studied how risk factors identified in childhood and adulthood predict pulse wave velocity assessed in adulthood. The study cohort consisted of 1691 white adults aged 30 to 45 years who had risk factor data available since childhood. Pulse wave velocity was assessed noninvasively by whole-body impedance cardiography. The number of conventional childhood and adulthood risk factors (extreme quintiles for low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, body mass index, and smoking) was directly associated with pulse wave velocity in adulthood (P=0.005 and P<0.0001, respectively). In multivariable regression analysis, independent predictors of pulse wave velocity were sex (P<0.0001), age (P<0.0001), childhood systolic blood pressure (P=0.002) and glucose (P=0.02), and adulthood systolic blood pressure (P<0.0001), insulin (P=0.0009), and triglycerides (P=0.003). Reduction in the number of risk factors (P<0.0001) and a favorable change in obesity status (P=0.0002) from childhood to adulthood were associated with lower pulse wave velocity in adulthood. Conventional risk factors in childhood and adulthood predict pulse wave velocity in adulthood. Favorable changes in risk factor and obesity status from childhood to adulthood are associated with lower pulse wave velocity in adulthood. These results support efforts for a reduction of conventional risk factors both in childhood and adulthood in the primary prevention of atherosclerosis.
Studies of the ABJM Theory in a Formulation with Manifest SU(4) R-Symmetry

We examine the three-dimensional Script N = 6 superconformal Chern-Simons theory with U(N) × U(N) gauge symmetry, which was recently constructed by Aharony, Bergman, Jafferis, and Maldacena (ABJM). Using a formulation with manifest SU(4) R-symmetry and no auxiliary fields, we verify in complete detail both the Poincare supersymmetry and the conformal supersymmetry of the action. Together, these imply the complete OSp(6|4) superconformal symmetry of the theory. The potential, which is sixth order in scalar fields, is recast as a sum of squares.
Abundance and Diversity of Bacterial Nitrifiers and Denitrifiers and Their Functional Genes in Tannery Wastewater Treatment Plants Revealed by High-Throughput Sequencing

Biological nitrification/denitrification is frequently used to remove nitrogen from tannery wastewater containing high concentrations of ammonia. However, information is limited about the bacterial nitrifiers and denitrifiers and their functional genes in tannery wastewater treatment plants (WWTPs) due to the low-throughput of the previously used methods. In this study, 454 pyrosequencing and Illumina high-throughput sequencing, combined with molecular methods, were used to comprehensively characterize structures and functions of nitrification and denitrification bacterial communities in aerobic and anaerobic sludge of two full-scale tannery WWTPs. Pyrosequencing of 16S rRNA genes showed that Proteobacteria and Synergistetes dominated in the aerobic and anaerobic sludge, respectively. Ammonia-oxidizing bacteria (AOB) amoA gene cloning revealed that Nitrosomonas europaea dominated the ammonia-oxidizing community in the WWTPs. Metagenomic analysis showed that the denitrifiers mainly included the genera of Thauera, Paracoccus, Hyphomicrobium, Comamonas and Azoarcus, which may greatly contribute to the nitrogen removal in the two WWTPs. It is interesting that AOB and ammonia-oxidizing archaea had low abundance although both WWTPs demonstrated high ammonium removal efficiency. Good correlation between the qPCR and metagenomic analysis is observed for the quantification of functional genes amoA, nirK, nirS and nosZ, indicating that the metagenomic approach may be a promising method used to comprehensively investigate the abundance of functional genes of nitrifiers and denitrifiers in the environment.
The menstruation experience: Attitude dimensions among South African students

This study aimed to investigate the attitudes and experiences regarding menstruation among undergraduate women at a historically disadvantaged South African university. A total of 255 women participated in the study. The majority of participants were black women (coloured = 55%; African = 29.2%). They responded to the Menstrual Attitudes Questionnaire (MAQ) and a demographic questionnaire. Data were analysed using descriptive statistics and ANOVA with post-hoc tests. The majority of women in the study (78%) had positive attitudes towards menstruation, viewing it as a natural event that can be anticipated and predicted. However, many of the women (51–58%) perceived it as debilitating and bothersome to everyday living. Menstruation was perceived by women as impacting on participation and performance in higher education, suggesting that the provision of tertiary education for previously disadvantaged groups needs to consider the needs of women who experience difficulty managing menstruation. The provision of material resources, education in self-care strategies and distribution of information to normalise menstruation may assist women to manage the potentially adverse impact of menstruation on their higher education experience.
Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.

One theory of immune regulation involves homeostasis between T-helper 1 (Th1) and T-helper 2 (Th2) activity. The Th1/Th2 hypothesis arose from 1986 research suggesting mouse T-helper cells expressed differing cytokine patterns. This hypothesis was adapted to human immunity, with Th1- and Th2-helper cells directing different immune response pathways. Th1 cells drive the type-1 pathway ("cellular immunity") to fight viruses and other intracellular pathogens, eliminate cancerous cells, and stimulate delayed-type hypersensitivity (DTH) skin reactions. Th2 cells drive the type-2 pathway ("humoral immunity") and up-regulate antibody production to fight extracellular organisms; type 2 dominance is credited with tolerance of xenografts and of the fetus during pregnancy. Overactivation of either pattern can cause disease, and either pathway can down-regulate the other. But the hypothesis has major inconsistencies; human cytokine activities rarely fall into exclusive pro-Th1 or -Th2 patterns. The non-helper regulatory T cells, or the antigen-presenting cells (APC), likely influence immunity in a manner comparable to Th1 and Th2 cells. Many diseases previously classified as Th1 or Th2 dominant fail to meet the set criteria. Experimentally, Th1 polarization is readily transformed to Th2 dominance through depletion of intracellular glutathione, and vice versa. Mercury depletes glutathione and polarizes toward Th2 dominance. Several nutrients and hormones measurably influence Th1/Th2 balance, including plant sterols/sterolins, melatonin, probiotics, progesterone, and the minerals selenium and zinc. The long-chain omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) significantly benefit diverse inflammatory and autoimmune conditions without any specific Th1/Th2 effect. Th1/Th2-based immunotherapies, e.g., T-cell receptor (TCR) peptides and interleukin-4 (IL-4) injections, have produced mixed results to date.
Evaluating mobile web search performance by taking good abandonment into account

Usage of mobile devices for Web search grows rapidly in recent years. The common tendency is that users want to receive information immediately results in incorporating rich snippets and vertical results into search engine result pages (SERPs) and in increasing of good abandonment. This article provides an offline metric for quality evaluation of mobile Web search, which takes good abandonment rate into consideration. The metric is the DBN click model that allows the probability to be satisfied directly on the SERP. The model parameters are estimated from the mobile search logs of a controlled experiment. The new metric outperforms traditional ERR metric in terms of the validation dataset built using a SERP degradation technique.
Neonatal hyper- and hypothyroidism alter the myoglobin gene expression program in adulthood

Myoglobin acts as an oxygen store and a reactive oxygen species acceptor in muscles. We examined myoglobin mRNA in rat cardiac ventricle and skeletal muscles during the first 42 days of life and the impact of transient neonatal hypo- and hyperthyroidism on the myoglobin gene expression pattern. Cardiac ventricle and skeletal muscles of Wistar rats at 7-42 days of life were quickly removed, and myoglobin mRNA was determined by Northern blot analysis. Rats were treated with propylthiouracil (5-10 mg/100 g) and triiodothyronine (0.5-50 µg/100 g) for 5, 15, or 30 days after birth to induce hypo- and hyperthyroidism and euthanized either just after treatment or at 90 days. During postnatal (P) days 7-28, the ventricle myoglobin mRNA remained unchanged, but it gradually increased in skeletal muscle (12-fold). Triiodothyronine treatment, from days P0-P5, increased the skeletal muscle myoglobin mRNA 1.5- to 4.5-fold; a 2.5-fold increase was observed in ventricle muscle, but only when triiodothyronine treatment was extended to day P15. Conversely, hypothyroidism at P5 markedly decreased (60%) ventricular myoglobin mRNA. Moreover, transient hyperthyroidism in the neonatal period increased ventricle myoglobin mRNA (2-fold), and decreased heart rate (5%), fast muscle myoglobin mRNA (30%) and body weight (20%) in adulthood. Transient hypothyroidism in the neonatal period also permanently decreased fast muscle myoglobin mRNA (30%) and body weight (14%). These results indicated that changes in triiodothyronine supply in the neonatal period alter the myoglobin expression program in ventricle and skeletal muscle, leading to specific physiological repercussions and alterations in other parameters in adulthood.
The Role of Interneurons in Shaping Purkinje Cell Responses in the Cerebellar Cortex

The well established anatomy of the cerebellar cortex has led to suggestions that cerebellar molecular layer interneurons laterally inhibit Purkinje cells. In support of the anatomical predictions, on-beam excitation and off-beam inhibition of Purkinje cells have been shown to occur when the surface of the cerebellum is electrically excited. Patchy excitation of Purkinje cells with flanking inhibition of sagittally oriented Purkinje cells have also been demonstrated following peripheral stimulation in vivo. To extend these observations, we mapped the functional connectivity between granule cells, molecular layer interneurons, and Purkinje cells in rats. Patches of granule cells were asynchronously activated by photostimulation to mimic their excitation by a mossy fiber as it occurs in vivo. We found with remarkable consistency that, in the sagittal orientation, granule cells elicit a stereotypic set of responses. Granule cells immediately underneath a Purkinje cell provide pure excitation. Granule cells positioned 340–400 μm laterally provided pure inhibition, consistent with the lateral inhibition proposed earlier. The net effect of exciting granule cells in between these two extremes was to provide a systematic change in the response of Purkinje cells, from net excitation to net inhibition moving laterally from the Purkinje cell. In contrast to the sagittal orientation, in the coronal orientation the organization of Purkinje cell responses with granule cell activation was remarkably different. Independent of the location of granule cells, within the 480 μm lateral distance examined, molecular layer interneurons reduced the strength of granule cell inputs to Purkinje cells to a comparable extent.