Miracle-dz/UniFAR-FTUs huggingface dataset:
How green is their valley? Subjective vitality of Welsh language and culture in the Chubut Province, Argentina

Abstract Drawing upon the theories and taxonomy of vitality, suggested by Giles, Bourhis, and Taylor (1977), a questionnaire was developed to uncover the subjective perceptions of Welsh language and culture in the Chubut Province. This questionnaire was distributed between September and November 2004 in seven locations with 369 completed questionnaires being returned by inhabitants of these municipalities. The distribution of the questionnaires included a wide cross-section of society to reflect perceptions of the strength of the Welsh language among the society as a whole and not just the Welsh community. This article concentrates upon important questions relating to the current perceptions of the strength of Welsh language and Welsh culture and perceptions of the prevailing historical and future trends. Analysis of the questionnaire results shows positive trends in informants' responses linked to the informants' affiliation to the Welsh community, fluency in oral Welsh, and location. Some significant differences exist according to the informants' age and the region of the province in which they live.
Effect of Color Coding on Visually and Verbally Oriented Tests with Students of Different Field Dependence Levels

To assess the impact of instructional color coding on visually and verbally oriented tests and on field-dependent-independent subjects, undergraduate college students (119) were randomly assigned to two treatment groups (color—black and white). These subjects received their respective treatment and received four dependent measures measuring four different types of educational objectives. Results indicated that the subject's level of field dependence is an important instructional variable and that color coding is an effective variable for maximizing information acquisition levels for field dependent over oriented subjects.
School Leadership and Performance: A Social Network Approach

Du fait de l'egalitarisme qui prevaut aupres des enseignants, ces derniers ont tendance a n'accorder et a ne soutenir que les directeurs d'etablissement qui font preuve de competence dans le domaine pedagogique. Les AA. estiment que cette conception ideologique empeche le developpement dans les etablissements scolaires d'un leadership informel. Ils montrent en meme temps que si le directeur ne dispose pas des pleins pouvoirs cela tendra a nuire a la coordination et au controle de l'activite de l'etablissement. Ils examinent, a l'aide d'une enquete menee en 1990 aux Etats-Unis (Californie) dans 17 ecoles du primaire et du secondaire et en utilisant l'analyse de reseau, le role des chefs d'etablissement en ce qui concerne le leadership et les performances scolaires
Zina and the enigma of sex education for Indonesian Muslim youth

Sexuality and sex education cannot be divorced from the moral values of the societies within which we must negotiate our sexual identities and relationships. Rather than pandering to the moral panic that is too often associated with the provision of sex education in non‐secular societies where religion is more visibly active in shaping sexual ideals and norms, this article takes up the challenge of investigating a relationship that is often represented as being innately contradictory. It explores the Islamic notion of zina (illicit sex) in relation to the provision of comprehensive sex education for Muslim youth in contemporary Indonesia. The article initially establishes the demand for sex education among Indonesian youth from the overlapping perspectives of health, human rights and Islam. It then explores the notion of zina in detail and exposes how Islamic stipulations against premarital sex are not necessarily in conflict with the provision of sex education. The final section of the article refines the argument in favour of utilizing Islam as a framework for developing religiously appropriate sex education and describes a suitable approach and content for Islamic sex education curricula for Indonesian youth.
The Efficacy of Psychodynamic Psychotherapy in Specific Mental Disorders: A 2013 Update of Empirical Evidence

Abstract This article reviews the empirical evidence for psychodynamic therapy for specific mental disorders in adults. The focus is on randomized controlled trials (RCTs). However, this does not imply that RCTs are uncritically accepted as the gold standard for demonstrating that a treatment works. According to the results presented here, there is evidence from RCTs that psychodynamic therapy is efficacious in common mental disorders, that is, depressive disorders, anxiety disorders, somatic symptom disorders, personality disorders, eating disorders, complicated grief, posttraumatic stress disorder (PTSD), and substance-related disorder. These results clearly contradict assertions repeatedly made by representatives of other psychotherapeutic approaches claiming psychodynamic psychotherapy is not empirically supported. However, further research is needed, both on outcome and processes of psychodynamic psychotherapy. There is a need, for example, for RCTs of psychodynamic psychotherapy of PTSD. Furthermore, research on long-term psychotherapy for specific mental disorders is required.
The presence of Web 2.0 tools on museum websites: a comparative study between England, France, Spain, Italy, and the USA

Abstract In recent years, the Internet has become a place for participation, collaboration, and social exchange thanks to Web 2.0 tools. Museum websites are starting to incorporate these tools to involve audiences in ways that reach beyond the physical museum visit. This paper presents research exploring the extent to which museums in five countries (Italy, France, Spain, England, and the USA) have adopted Web 2.0 tools on their websites. Two hundred and forty museum websites belonging to four categories (arts, natural sciences, social sciences, and specialized) were analyzed, with results showing a low overall presence of Web 2.0 tools on museum websites, as well as significant differences in the use of Web 2.0 tools among countries and categories. The paper concludes with a discussion of the diversity of approaches in the use of Web 2.0 tools on museum websites.
Impaired Response to Acetylcholine Despite Intact Endothelium‐Derived Relaxing Factor/Nitric Oxide in Isolated Microperfused Afferent Arterioles of the Spontaneously Hypertensive Rat

Summary: The major characteristic of renal hemodynamics in hypertension is abnormally high resistance of the preglomerular vessel, most likely the afferent arteriole (Af‐Art). Although endothelium‐derived relaxing factor (EDRF)/nitric oxide (NO) has been studied extensively in large vessels, little is known about its role in Af‐Art reactivity. Using isolated microperfused Af‐Arts of 12‐ to 13‐week‐old spontaneously hypertensive rats (SHRs) and their normotensive control, Wistar‐Kyoto (WKY) rats, we examined the effect of acetylcholine (ACh) or N&ohgr;‐nitro‐L‐arginine (l‐NAME), which stimulates or blocks endothelium‐derived NO, respectively. Af‐Arts were preconstricted with norepinephrine to 70 ± 5 and 62 ± 4% of the control diameter in SHRs and WKY rats, respectively; the intraluminal pressure was kept at either 100 or 70 mm Hg. In SHRs, ACh (1 nM‐0.1 mM) added to the Af‐Art perfusate caused no vasodilation but tended to decrease the diameter further to 59 ± 6% of control (N = 8). In contrast, in WKY rats, ACh reversed the luminal diameter to 90 ± 4% of control (N = 6, p < 0.01 compared with SHRs). Contrary to the responses to ACh, blockade of endothelium‐derived NO with l‐NAME decreased the basal diameter by 31 ± 8 and 14 ± 5% in SHRs and WKY rats, respectively. We conclude that ACh‐induced vasodilation is impaired in SHR Af‐Art. The impaired response to ACh may be due to factors other than endothelium‐derived NO such as endothelium‐derived contracting factor (EDCF).
Infusing Culturally Responsive Instruction to Improve Mathematics Performance of Latino Students with Specific Learning Disabilities

Culturally responsive instruction has the advantage of helping diverse students make academic gains. The purpose of this study was to investigate the effects of culturally infused mathematics lessons on the academic achievement of five middle school Latino students with specific learning disabilities in a resource classroom. We used an ABACACA multiple treatment reversal design, in which two forms of culturally responsive instruction (B) and its modification (C) were compared with the traditional instruction (A). The results of the study indicated that the modified culturally responsive mathematics instruction (C) was associated with increases in positive gains in participants' daily mathematics quizzes. Limitations and implications are discussed in relation to culturally responsive instruction for middle school Latino students with specific learning disabilities.
Race, Class, and Gender Differences in High School Seniors' Values: Applying Intersection Theory in Empirical Analysis

Objective. This article demonstrates how intersection theory can be applied in empirical studies by testing whether an individual's race, class, and gender have interactive effects. Methods. Data on high school students' ratings of the importance of equality, money, career, and family from the Monitoring the Future study are used. A stepwise regression model is employed to determine first whether additive effects exist in the data, and then whether interactions exist among race, class, and gender characteristics. Results. Previous findings of additive effects were generally confirmed in the first stage of the regressions, with some exceptions. For the money and family values, significant interactions exist between some pairs of characteristics, but three-way interactions were not significant. For equality and career values, no significant interactions were found. Conclusions. Although there are times when additive models are sufficient to describe differences among groups, the omission of interaction terms can sometimes lead to misleading conclusions about the effects of race, class, and gender. Using intersection theory in empirical models will guard against this oversight and may lead to a broad theory of when significant race, class, and gender interactions should be expected.
Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment

ABSTRACT Dysfunction of PTEN-induced putative kinase 1 (PINK1), a Ser/Thr kinase with an N-terminal mitochondrial-targeting sequence (MTS), causes familial recessive parkinsonism. Reduction of the mitochondrial membrane potential limits MTS-mediated matrix import and promotes PINK1 accumulation on the outer mitochondrial membrane (OMM) of depolarized mitochondria. PINK1 then undergoes autophosphorylation and phosphorylates ubiquitin and Parkin, a cytosolic ubiquitin ligase, for clearance of damaged mitochondria. The molecular basis for PINK1 localization on the OMM of depolarized mitochondria rather than release to the cytosol is poorly understood. Here, we disentangle the PINK1 localization mechanism using deletion mutants and a newly established constitutively active PINK1 mutant. Disruption of the MTS through N-terminal insertion of aspartic acid residues results in OMM localization of PINK1 in energized mitochondria. Unexpectedly, the MTS and putative transmembrane domain (TMD) are dispensable for OMM localization, whereas mitochondrial translocase Tom40 (also known as TOMM40) and an alternative mitochondrial localization signal that resides between the MTS and TMD are required. PINK1 utilizes a mitochondrial localization mechanism that is distinct from that of conventional MTS proteins and that presumably functions in conjunction with the Tom complex in OMM localization when the conventional N-terminal MTS is inhibited.
Mass data processing of time series Landsat imagery: pixels to data products for forest monitoring

ABSTRACT Free and open access to the Landsat archive has enabled the implementation of national and global terrestrial monitoring projects. Herein, we summarize a project characterizing the change history of Canada’s forested ecosystems with a time series of data representing 1984–2012. Using the Composite2Change approach, we applied spectral trend analysis to annual best-available-pixel (BAP) surface reflectance image composites produced from Landsat TM and ETM+ imagery. A total of 73,544 images were used to produce 29 annual image composites, generating ∼400 TB of interim data products and resulting in ∼25 TB of annual gap-free reflectance composites and change products. On average, 10% of pixels in the annual BAP composites were missing data, with 86% of pixels having data gaps in two consecutive years or fewer. Change detection overall accuracy was 89%. Change attribution overall accuracy was 92%, with higher accuracy for stand-replacing wildfire and harvest. Changes were assigned to the correct year with an accuracy of 89%. Outcomes of this project provide baseline information and nationally consistent data source to quantify and characterize changes in forested ecosystems. The methods applied and lessons learned build confidence in the products generated and empower others to develop or refine similar satellite-based monitoring projects.
Finding Patterns Avoiding Many Monochromatic Constellations

Given fixed 0 = q 0 < q 1 < q 2 < … < qk = 1, a constellation in [n] is a scaled translated realization of the qi with all elements in [n], i.e., p, p + q 1 d, p + q 2 d, …, p + q k–1 d, p + d. We consider the problem of minimizing the number of monochromatic constellations in a two-coloring of [n]. We show how, given a coloring based on a block pattern, to find the number of monochromatic solutions to a lower-order term, and also how experimentally we might find an optimal block pattern. We also show for the case k = 2 that there is always a block pattern that beats random coloring.
Follow‐up study of ex‐students of a residential school for children with emotional and behavioural difficulties in New Zealand

A follow‐up study was conducted on ex‐students of a residential special school for children with emotional and behavioural difficulties in New Zealand. Previous research on post‐school outcomes for students with emotional and behavioural difficulties has found low levels on quality of life indicators such as education, employment and community adjustment. Twenty‐nine ex‐students and/or their parents or caregivers were located and interviewed 10–14 years after they had left residential school. Interviews focused on their educational achievement, employment record and community adjustment. Findings indicated low levels of achievement in terms of educational qualifications and employment records, high rates of involvement with the criminal justice system and low levels of community adjustment. Implications of the study findings suggest that key factors in improving student outcomes are establishing effective procedures for transition, providing ongoing support for ex‐students, and better special needs training for teachers in mainstream schools.
Provider Perspectives on Aftercare Services for Youth in Residential Care

The provision of aftercare services for youth and families is an important topic in residential care. Focus groups were conducted with seven service professionals working with youth in residential care in the United States. Providers responded to two questions: Based on your involvement in residential care 1) what barriers do providers experience when trying to access aftercare services for youth who are departing residential care; and 2) what solutions have providers attempted or recommended to overcome barriers so that aftercare services are made available to youth? Common themes for barriers included: 1) Youth/Family barriers to engagement; 2) Aftercare programming issues and concerns; 3) State, local, and agency policy; 4) Lack of funding; and 5) Lack of interagency collaboration. Common themes for solutions included: 1) Continuity of care; 2) State, local, and agency policy recommendations; 3) Family engagement; 4) Funding solutions; 5) Discharge planning; 6) Agency collaboration; and 7) Technology. Study limitations, future research, and implications are discussed.
Physical problem solving: Joint planning with symbolic, geometric, and dynamic constraints

In this paper, we present a new task that investigates how people interact with and make judgments about towers of blocks. In Experiment~1, participants in the lab solved a series of problems in which they had to re-configure three blocks from an initial to a final configuration. We recorded whether they used one hand or two hands to do so. In Experiment~2, we asked participants online to judge whether they think the person in the lab used one or two hands. The results revealed a close correspondence between participants' actions in the lab, and the mental simulations of participants online. To explain participants' actions and mental simulations, we develop a model that plans over a symbolic representation of the situation, executes the plan using a geometric solver, and checks the plan's feasibility by taking into account the physical constraints of the scene. Our model explains participants' actions and judgments to a high degree of quantitative accuracy.
"Species" radiations of symbiotic dinoflagellates in the Atlantic and Indo-Pacific since the Miocene-Pliocene transition.

Endosymbiotic dinoflagellates, or "zooxanthellae," are required for the survival of a diverse community of invertebrates that construct and dominate shallow, tropical coral reef ecosystems. Molecular systematics applied to this once understudied symbiont partner, Symbiodinium spp. , divide the group into divergent lineages or subgeneric "clades. " Within each clade, numerous closely related "types," or species, exhibit distinctive host taxon, geographic, and/or environmental distributions. This diversity is greatest in clade C, which dominates the Indo-Pacific host fauna and shares dominance in the Atlantic-Caribbean with clade B. Two "living" ancestors in this group, C1 and C3, are common to both the Indo-Pacific and Atlantic-Caribbean. With these exceptions, each ocean possesses a diverse clade C assemblage that appears to have independently evolved (adaptively radiated) through host specialization and allopatric differentiation. This phylogeographic evidence suggests that a worldwide selective sweep of C1/C3, or their progenitor, must have occurred before both oceans separated. The probable timing of this event corresponds with the major climactic changes and low CO(2) levels of the late Miocene and/or early Pliocene. Subsequent bursts of diversification have proceeded in each ocean since this transition. An ecoevolutionary expansion to numerous and taxonomically diverse hosts by a select host-generalist symbiont followed by the onset of rapid diversification suggests a radical process through which coral-algal symbioses respond and persist through the vicissitudes of planetary climate change.
Activity-Dependent Fusion Pore Expansion Regulated by a Calcineurin-Dependent Dynamin-Syndapin Pathway in Mouse Adrenal Chromaffin Cells

Neuroendocrine chromaffin cells selectively secrete a variety of transmitter molecules into the circulation as a function of sympathetic activation. Activity-dependent release of transmitter species is controlled through regulation of the secretory fusion pore. Under sympathetic tone, basal synaptic excitation drives chromaffin cells to selectively secrete modest levels of catecholamine through a restricted secretory fusion pore. In contrast, elevated sympathetic activity, experienced under stress, results in fusion pore expansion to evoke maximal catecholamine release and to facilitate release of copackaged peptide transmitters. Therefore, fusion pore expansion is a key control point for the activation of the sympatho-adrenal stress response. Despite the physiological importance of this process, the molecular mechanism by which it is regulated remains unclear. Here we employ fluorescence imaging with electrophysiological and electrochemical-based approaches to investigate the role of dynamin I in the regulation of activity-mediated fusion pore expansion in mouse adrenal chromaffin cells. We show that under elevated stimulation, dynamin I is dephosphorylated at Ser-774 by calcineurin. We also demonstrate that disruption of dynamin I-syndapin binding, an association regulated by calcineurin-dependent dynamin dephosphorylation, limits fusion pore expansion. Last, we show that perturbation of N-WASP function (a syndapin substrate) limits activity-mediated fusion pore expansion. Our results suggest that fusion pore expansion is regulated by a calcineurin-dependent dephosphorylation of dynamin I. Dephosphorylated dynamin I acts via a syndapin/N-WASP signaling cascade to mediate pore expansion.
Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae

The PH domain-containing proteins Slm1 and Slm2 were originally identified as substrates of the rapamycin-insensitive TOR complex 2 (TORC2) and as mediators of signaling by the lipid second messenger phosphatidyl-inositol-4,5-bisphosphate (PI4,5P2) in budding yeast S. cerevisiae. More recently, these proteins have been identified as critical effectors that facilitate phosphorylation and activation of the AGC kinases Ypk1 and Ypk2 by TORC2.1 Here, we review the molecular basis for this regulation as well as place it within the context of recent findings that have revealed Slm1/2 and TORC2-dependent phosphorylation of Ypk1 is coupled to the biosynthesis of complex sphingolipids and to their levels within the plasma membrane (PM) as well as other forms of PM stress. Together, these studies reveal the existence of an intricate homeostatic feedback mechanism, whereby the activity of these signaling components is linked to the biosynthesis of PM lipids according to cellular need.
Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

Beta-sitosterol (BS) is a phytosterol, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. To compile the sources, physical and chemical properties, spectral and chromatographic analytical methods, synthesis, systemic effects, pharmacokinetics, therapeutic potentials, toxicity, drug delivery and finally, to suggest future research with BS, classical as well as on-line literature were studied. Classical literature includes classical books on ethnomedicine and phytochemistry, and the electronic search included Pubmed, SciFinder, Scopus, the Web of Science, Google Scholar, and others. BS could be obtained from different plants, but the total biosynthetic pathway, as well as its exact physiological and structural function in plants, have not been fully understood. Different pharmacological effects have been studied, but most of the mechanisms of action have not been studied in detail. Clinical trials with BS have shown beneficial effects in different diseases, but long-term study results are not available. These have contributed to its current status as an “orphan phytosterol”. Therefore, extensive research regarding its effect at cellular and molecular level in humans as well as addressing the claims made by commercial manufacturers such as the cholesterol lowering ability, immunological activity etc. are highly recommended.