Miracle-dz/UniFAR-FTUs huggingface dataset:
A Clinimetric Overview of Scar Assessment Scales

Standardized validated evaluation instruments are mandatory to increase the level of evidence in scar management. Scar assessment scales are potentially suitable for this purpose, but the most appropriate scale still needs to be determined. This review will elaborate on several clinically relevant scar features and critically discuss the currently available scar scales in terms of basic clinimetric requirements. Many current scales can produce reliable measurements but seem to require multiple observers to obtain these results reliably, which limits their feasibility in clinical practice. The validation process of scar scales is hindered by the lack of a “gold standard” in subjective scar assessment or other reliable objective instruments which are necessary for a good comparison. The authors conclude that there are scar scales available that can reliably measure scar quality. However, further research may lead to improvement of their clinimetric properties and enhance the level of evidence in scar research worldwide.
Sugarcane Aphid Population Growth, Plant Injury, and Natural Enemies on Selected Grain Sorghum Hybrids in Texas and Louisiana

Abstract In response to the 2013 outbreak of sugarcane aphid, Melanaphis sacchari (Zehntner) (Hemiptera: Aphididae), on sorghum, Sorghum bicolor (L.), in North America, experiments were conducted at three southern U.S. grain sorghum production locations (Corpus Christi, TX; Winnsboro, LA; Rosenberg, TX). The objectives were to authenticate yield decline on susceptible hybrids (2014 and 2015) and to measure aphid population growth and natural enemy prevalence on susceptible and resistant hybrids with similar genetic background (2014). Yield decline on susceptible hybrids (Tx 2752/Tx430 and DKS53-67) was more substantial when aphid population growth accelerated quickly and peaked above 300 aphids per leaf (50 to nearly 100% yield decline). Location and year variation in maximum aphid density and cumulative aphid-days was high, with doubling time values on the susceptible hybrids ranging between 3.9 and 7.9 d. On resistant Tx2752/Tx2783, leaf injury and yield decline were not seen or less severe than on its paired susceptibleTx2752/Tx430. Aphids declined onTx2752/Tx2783 after initial colony establishment (Corpus Christi) or took about 60% longer to double in population size when compared with Tx2572/Tx430 (Winnsboro). The predominant natural enemy taxa were aphelinid mummies (Hymenoptera: Aphelinidae), ladybird beetles (Coleoptera: Coccinellidae), and sryphid flies (Diptera: Syrphidae), and they were more prevalent during flowering than prior to flowering.They were generally responsive to changes in aphid density of both susceptible and resistant hybrids, but variability points to need for further study. In future research, full season observations should continue as well as more detailed study of potential compatibility of sorghum resistance and biological control.
Depression, Negative Emotionality, and Self-Referential Language: A Multi-Lab, Multi-Measure, and Multi-Language-Task Research Synthesis

Depressive symptomatology is manifested in greater first-person singular pronoun use (i.e., I-talk), but when and for whom this effect is most apparent, and the extent to which it is specific to depression or part of a broader association between negative emotionality and I-talk, remains unclear. Using pooled data from N = 4,754 participants from 6 labs across 2 countries, we examined, in a preregistered analysis, how the depression–I-talk effect varied by (a) first-person singular pronoun type (i.e., subjective, objective, and possessive), (b) the communication context in which language was generated (i.e., personal, momentary thought, identity-related, and impersonal), and (c) gender. Overall, there was a small but reliable positive correlation between depression and I-talk (r = .10, 95% CI [.07, .13]). The effect was present for all first-person singular pronouns except the possessive type, in all communication contexts except the impersonal one, and for both females and males with little evidence of gender differences. Importantly, a similar pattern of results emerged for negative emotionality. Further, the depression–I-talk effect was substantially reduced when controlled for negative emotionality but this was not the case when the negative emotionality–I-talk effect was controlled for depression. These results suggest that the robust empirical link between depression and I-talk largely reflects a broader association between negative emotionality and I-talk. Self-referential language using first-person singular pronouns may therefore be better construed as a linguistic marker of general distress proneness or negative emotionality rather than as a specific marker of depression.
Improved circRNA Identification by Combining Prediction Algorithms

Non-coding RNA is an interesting class of gene regulators with diverse functionalities. One large subgroup of non-coding RNAs is the recently discovered class of circular RNAs (circRNAs). CircRNAs are conserved and expressed in a tissue and developmental specific manner, although for the vast majority, the functional relevance remains unclear. To identify and quantify circRNAs expression, several bioinformatic pipelines have been developed to assess the catalog of circRNAs in any given total RNA sequencing dataset. We recently compared five different algorithms for circRNA detection, but here this analysis is extended to 11 algorithms. By comparing the number of circRNAs discovered and their respective sensitivity to RNaseR digestion, the sensitivity and specificity of each algorithm are evaluated. Moreover, the ability to predict de novo circRNA, i.e., circRNAs not derived from annotated splice sites, is also determined as well as the effect of eliminating low quality and adaptor-containing reads prior to circRNA prediction. Finally, and most importantly, all possible pair-wise combinations of algorithms are tested and guidelines for algorithm complementarity are provided. Conclusively, the algorithms mostly agree on highly expressed circRNAs, however, in many cases, algorithm-specific false positives with high read counts are predicted, which is resolved by using the shared output from two (or more) algorithms.
Towards Inferring Communication Patterns in Online Social Networks

The separation between the public and private spheres on online social networks is known to be, at best, blurred. On the one hand, previous studies have shown how it is possible to infer private attributes from publicly available data. On the other hand, no distinction exists between public and private data when we consider the ability of the online social network (OSN) provider to access them. Even when OSN users go to great lengths to protect their privacy, such as by using encryption or communication obfuscation, correlations between data may render these solutions useless. In this article, we study the relationship between private communication patterns and publicly available OSN data. Such a relationship informs both privacy-invasive inferences as well as OSN communication modelling, the latter being key toward developing effective obfuscation tools. We propose an inference model based on Bayesian analysis and evaluate, using a real social network dataset, how archetypal social graph features can lead to inferences about private communication. Our results indicate that both friendship graph and public traffic data may not be informative enough to enable these inferences, with time analysis having a non-negligible impact on their precision.
Knowledge and attitudes toward female genital cutting among West African male immigrants in New York City

ABSTRACT In this project, we explored knowledge and attitudes toward female genital cutting (FGC) in a survey of 107 West African immigrants, including 36 men. Men in this study were as knowledgeable about the health consequences of FGC as women, though with a less nuanced understanding. They also rejected the practice at rates comparable to women. Despite this knowledge and rejection of FGC, most men did not express a personal preference for women with or without FGC in intimate relationships. Future research and interventions must explore men's opposition to FGC and emphasize the impact of FGC on their partners' gynecological and reproductive health.
Sequence Classification of the Limit Order Book Using Recurrent Neural Networks

Recurrent neural networks (RNNs) are types of artificial neural networks (ANNs) that are well suited to forecasting and sequence classification. They have been applied extensively to forecasting univariate financial time series, however their application to high frequency trading has not been previously considered. This paper solves a sequence classification problem in which a short sequence of observations of limit order book depths and market orders is used to predict a next event price-flip. The capability to adjust quotes according to this prediction reduces the likelihood of adverse price selection. Our results demonstrate the ability of the RNN to capture the non-linear relationship between the near-term price-flips and a spatio-temporal representation of the limit order book. The RNN compares favorably with other classifiers, including a linear Kalman filter, using S&P500 E-mini futures level II data over the month of August 2016. Further results assess the effect of retraining the RNN daily and the sensitivity of the performance to trade latency.
Spectrum of cardiovascular diseases in six main referral hospitals of Ethiopia

Background The spectrum of cardiovascular diseases varies between and within countries, depending on the stage of epidemiological transition and risk factor profiles. Understanding this spectrum requires regional and national data for each region or country. This study was designed to determine the spectrum of cardiovascular diseases in six university hospitals in Ethiopia. Methods This is a cross-sectional study of the spectrum of cardiovascular diseases in six main referral/teaching hospitals located in different parts of the country. Consecutive patients visiting the follow-up cardiac clinics of these hospitals from 1 January to 30 June 2015 were included in the study. Data were collected on a pretested questionnaire. Results A total of 6275 patients (58.5% females) were included in the study. Nearly 61% of the patients were from urban areas. The median age was 33 years (IQR 14–55 years). Valvular heart disease was the most common diagnosis, accounting for 40.5% of the cases. Of 2541 patents with valvular heart disease, 2184 (86%) were cases of chronic rheumatic heart disease. Conclusion Our study shows that chronic rheumatic valvular heart disease is the most common cardiovascular diagnosis among patients seen at cardiology clinics of six referral/teaching hospitals in the country, followed by congenital heart diseases. Hypertensive and ischaemic heart diseases also accounted for a significant proportion of the cases. Therefore, strategies directed towards primary and secondary prevention of acute rheumatic fever as well as prevention of risk factors for hypertension and ischaemic heart disease may need to be strengthened.
Long-Term Effects of Safinamide on Mood Fluctuations in Parkinson’s Disease

Background: Mood disorders are very frequent in Parkinson’s Disease (PD), and their effective treatment is still a major unresolved issue: growing evidence suggests that glutamatergic system dysfunction is directly involved. Safinamide is a drug with an innovative mechanism of action, dopaminergic and non-dopaminergic, that includes the reversible inhibition of the monoamine oxidase-B (MAO-B) enzyme and the modulation of excessive glutamate release through the use- and state-dependent blockade of the sodium channels. Objective: To investigate the effects of safinamide on mood over two-year treatment in PD patients with motor fluctuations. Methods: This was a post-hoc analysis of the data from studies 016 and 018. The analysis focused on outcomes related to mood, namely: scores of the “Emotional well-being” domain of the Parkinson’s Disease Questionnaire (PDQ-39), scores of the GRID Hamilton Rating Scale for Depression (GRID-HAMD) and the proportion of patients reporting depression as an adverse event over the entire treatment period. Results: Safinamide, compared to placebo, significantly improved the PDQ-39 “Emotional well-being” domain after6-months (p = 0.0067) and 2 years (p = 0.0006), as well as the GRID-HAMD (p = 0.0408 after 6 months and p = 0.0027 after 2 years). Significantly fewer patients in the safinamide group, compared to placebo, experienced depression as adverse event (p = 0.0444 after 6 months and p = 0.0057 after 2 years). Conclusion: The favorable effect of safinamide on mood may be explained by the improvement in wearing off and by its modulation of glutamatergic hyperactivity and reversible MAO-B inhibition. Prospective studies are warranted to investigate this potential benefit.
Under the Weather: Health, Schooling, and Economic Consequences of Early-Life Rainfall.

How sensitive is long-run individual well-being to environmental conditions early in life? This paper examines the effect of weather conditions around the time of birth on the health, education, and socioeconomic outcomes of Indonesian adults born between 1953 and 1974. We link historical rainfall for each individual's birth-year and birth-location with current adult outcomes from the 2000 wave of the Indonesia Family Life Survey. Higher early-life rainfall has large positive effects on the adult outcomes of women, but not of men. Women with 20% higher rainfall (relative to normal local rainfall) in their year and location of birth are 3.8 percentage points less likely to self-report poor or very poor health, attain 0.57 centimeters greater height, complete 0.22 more grades of schooling, and live in households that score 0.12 standard deviations higher on an asset index. These patterns most plausibly reflect a positive impact of rainfall on agricultural output, leading to higher household incomes and food availability and better health for infant girls. We present suggestive evidence that eventual benefits for adult women's socioeconomic status are most strongly mediated by improved schooling attainment, which in turn improves socioeconomic status in adulthood.
Omnidirectional Dielectric Resonator Antenna With a Planar Feed for Circular Polarization Diversity Design

The cylindrical dielectric resonator (DR) antenna (DRA) is excited in its omnidirectional TM<inline-formula> <tex-math notation="LaTeX">$_{01\delta }$ </tex-math></inline-formula> mode by a planar shorted microstrip cross. With this nonintrusive feed, the DRA can be fabricated without the need of drilling a hole in the DR as required in the probe feed method. This DRA is applied to the first omnidirectional circularly polarized (CP) diversity DRA. To generate omnidirectional CP fields, the TM<inline-formula> <tex-math notation="LaTeX">$_{01\delta }$ </tex-math></inline-formula> and TE<inline-formula> <tex-math notation="LaTeX">$_{011+\delta }$ </tex-math></inline-formula> modes are excited simultaneously. The TE<inline-formula> <tex-math notation="LaTeX">$_{011+\delta }$ </tex-math></inline-formula> mode is excited by four microstrip arcs. They provide a pair of equivalent magnetic dipoles that generate fields that are orthogonal to those of the TM<inline-formula> <tex-math notation="LaTeX">$_{01\delta }$ </tex-math></inline-formula> mode. Omnidirectional CP fields can be obtained when the (orthogonal) fields of the TM<inline-formula> <tex-math notation="LaTeX">$_{01\delta }$ </tex-math></inline-formula> and TE<inline-formula> <tex-math notation="LaTeX">$_{011+\delta }$ </tex-math></inline-formula> modes are equal in amplitude but in phase quadrature. In our two-port CP diversity design, phase differences of +90° and −90° are obtained in ports 1 and 2 to generate right- and left-hand CP fields, respectively. Prototypes at ~2.4 GHz were designed, fabricated, and measured for WLAN applications. The S-parameters, radiation patterns, antenna gains, and efficiencies are studied. For the diversity design, the axial ratio, envelope correlation coefficient, and mean effective gain are also obtained. The measured and simulation results are in reasonable agreement.
Switching regimens in virologically suppressed HIV‐1‐infected patients: evidence base and rationale for integrase strand transfer inhibitor (INSTI)‐containing regimens

In an era when most individuals with treated HIV infection can expect to live into old age, clinicians should proactively review their patients’ current and future treatment needs and challenges. Clinical guidelines acknowledge that, in the setting of virological suppression, treatment switch may yield benefits in terms of tolerability, regimen simplification, adherence, convenience and long‐term health considerations, particularly in the context of ageing. In this paper, we review evidence from six key clinical studies on switching virologically suppressed patients to regimens based on integrase strand transfer inhibitors (INSTIs), the antiretroviral class increasingly preferred as initial therapy in clinical guidelines. We review these studies and focus on the virological efficacy, safety, and tolerability of switching to INSTI‐based regimens in suppressed HIV‐positive individuals. We review the early switch studies SWITCHMRK and SPIRAL [assessing a switch from a ritonavir‐boosted protease inhibitor (PI/r) to raltegravir (RAL)‐containing regimens], together with data from STRATEGY‐PI [assessing a switch to elvitegravir (EVG)‐containing regimens; EVG/cobicistat (COBI)/emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) vs. remaining on a PI/r‐containing regimen], STRATEGY‐NNRTI [assessing a switch to EVG/COBI/FTC/TDF vs. continuation of a nonnucleoside reverse transcriptase inhibitor (NNRTI) and two nucleoside reverse transcriptase inhibitors (NRTIs)], STRIIVING [assessing a switch to a dolutegravir (DTG)‐containing regimen (abacavir (ABC)/lamivudine (3TC)/DTG) vs. staying on the background regimen], and GS study 109 [assessing a switch to EVG/COBI/FTC/tenofovir alafenamide fumarate (TAF) vs. continuation of FTC/TDF‐based regimens]. Switching to INSTI‐containing regimens has been shown to support good virological efficacy, with evidence from two studies demonstrating superior virological efficacy for a switch to EVG‐containing regimens. In addition, switching to INSTI regimens was associated with improved tolerability and greater reported patient satisfaction and outcomes in some studies. INSTI‐based regimens offer an important contemporary switch option that may be tailored to meet and optimize the needs of many patients.
The genome of the freshwater monogonont rotifer Brachionus calyciflorus

Monogononta is the most speciose class of rotifers, with more than 2,000 species. The monogonont genus Brachionus is widely distributed at a global scale, and a few of its species are commonly used as ecological and evolutionary models to address questions related to aquatic ecology, cryptic speciation, evolutionary ecology, the evolution of sex and ecotoxicology. With the importance of Brachionus species in many areas of research, it is remarkable that the genome has not been characterized. This study aims to address this lacuna by presenting, for the first time, the whole‐genome assembly of the freshwater species Brachionus calyciflorus. The total length of the assembled genome was 129.6 Mb, with 1,041 scaffolds. The N50 value was 786.6 kb, and the GC content was 24%. A total of 16,114 genes were annotated with repeat sequences, accounting for 21% of the assembled genome. This assembled genome may form a basis for future studies addressing key questions on the evolution of monogonont rotifers. It will also provide the necessary molecular resources to mechanistically investigate ecophysiological and ecotoxicological responses.
Effect of processing parameters, antistiction coatings, and polymer type when injection molding microfeatures

Thermoplastic polyurethane (TPU) and silicon tooling with microscale features on its surface was employed to investigate the impact of three factors on the quality of injection molded microscale features: (1) optimized process parameters, (2) use of a more flexible thermoplastic material, and (3) used as an antistiction coating. The molded parts and tooling surface were characterized by atomic force, confocal, and scanning electron microscopy. Although both improved filling of the tooling trenches, higher mold temperatures significantly enhanced replication, but faster injection velocities contributed moderately to replication quality. With medium aspect ratio (2.3:1) trenches, the antistiction coating doubled depth ratios, enhanced the edge definition and flatness of the features, and significantly reduced tearing of the features during ejection. The flexibility of the TPU permitted easier part ejection and left less polymer residue on the tooling surface in comparison to polycarbonate and other thermoplastic polymers. POLYM. ENG. SCI., 2010. © 2009 Society of Plastics Engineers
A Facile Strategy to Enhance the Dielectric and Mechanical Properties of MWCNTs/PVDF Composites with the Aid of MMA-co-GMA Copolymer

A facile strategy is adopted to prepare carboxylic functionalized multiwalled carbon nanotube (c-MWCNT) modified high dielectric constant (high-k) poly(vinylidene fluoride) (PVDF) composites with the aid of methyl methacrylate-co-glycidyl methacrylate copolymer (MG). The MG is miscible with PVDF and the epoxy groups of the copolymer can react with the carboxylic groups of c-MWCNT, which induce the uniform dispersion of c-MWCNT and a form insulator layer on the surface of c-MWCNT. The c-MWCNTs/MG/PVDF composites with 8 vol % c-MWCNT present excellent dielectric properties with high dielectric constant (~448) and low dielectric loss (~2.36) at the frequency of 1 KHz, the dielectric loss is much lower than the c-MWCNT/PVDF composites without MG. The obvious improvement in dielectric properties ascribes to the existence of MG, which impede the direct contact of c-MWCNTs and PVDF and avoid the formation of conductive network. Therefore, we propose a practical and simple strategy for preparing composites with excellent dielectric properties, which are promising for applications in electronics devices.
Semi-parametric Topological Memory for Navigation

We introduce a new memory architecture for navigation in previously unseen environments, inspired by landmark-based navigation in animals. The proposed semi-parametric topological memory (SPTM) consists of a (non-parametric) graph with nodes corresponding to locations in the environment and a (parametric) deep network capable of retrieving nodes from the graph based on observations. The graph stores no metric information, only connectivity of locations corresponding to the nodes. We use SPTM as a planning module in a navigation system. Given only 5 minutes of footage of a previously unseen maze, an SPTM-based navigation agent can build a topological map of the environment and use it to confidently navigate towards goals. The average success rate of the SPTM agent in goal-directed navigation across test environments is higher than the best-performing baseline by a factor of three. A video of the agent is available at this https URL