Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation

Hypoxia-inducible factor 1 (HIF-1), the major transcription factor specifically activated during hypoxia, regulates genes involved in critical aspects of cancer biology, including angiogenesis, cell proliferation, glycolysis and invasion. The HIF-1a subunit is stabilized by low oxygen, genetic alteration and cobaltous ions, and its over-expression correlates with drug resistance and increased cancer mortality in various cancer types, therefore representing an important anticancer target. Zinc supplementation has been shown to counteract the hypoxic phenotype in cancer cells, in vitro and in vivo, hence, understanding the molecular pathways modulated by zinc under hypoxia may provide the basis for reprogramming signalling pathways for anticancer therapy. Here we performed genome-wide analyses of colon cancer cells treated with combinations of cobalt, zinc and anticancer drug and evaluated the effect of zinc on gene expression patterns. Using Principal Component Analysis we found that zinc markedly reverted the cobalt-induced changes of gene expression, with reactivation of the drug-induced transcription of pro-apoptotic genes. We conclude that the hypoxia pathway is a potential therapeutic target addressed by zinc that also influences tumor cell response to anticancer drug.
Human and Canine Echinococcosis Infection in Informal, Unlicensed Abattoirs in Lima, Peru

Echinococcus granulosus infections are a major public health problem in livestock-raising regions around the world. The life cycle of this tapeworm is sustained between dogs (definitive host, canine echinococcosis), and herbivores (intermediary host, cystic hydatid disease). Humans may also develop cystic hydatid disease. Echinococcosis is endemic in rural areas of Peru; nevertheless, its presence or the extension of the problem in urban areas is basically unknown. Migration into Lima, an 8-million habitant's metropolis, creates peripheral areas where animals brought from endemic areas are slaughtered without veterinary supervision. We identified eight informal, unlicensed abattoirs in a peripheral district of Lima and performed a cross-sectional study in to assess the prevalence of canine echinococcosis, evaluated by coproELISA followed by PCR evaluation and arecoline purge. Eight of 22 dogs (36%) were positive to coproELISA, and four (18%) were confirmed to be infected with E. granulosus tapeworms either by PCR or direct observation (purge). Later evaluation of the human population living in these abattoirs using abdominal ultrasound, chest X-rays and serology, found 3 out of 32 (9.3%) subjects with echinococcal cysts in the liver (two viable, one calcified), one of whom had also lung involvement and a strongly positive antibody response. Autochthonous transmission of E. granulosus is present in Lima. Informal, unlicensed abattoirs may be sources of infection to neighbouring people in this urban environment.
Strain-dependent electrical resistance of multi-walled carbon nanotube/polymer composite films

The strain-dependent electrical resistance characteristics of multi-walled carbon nanotube (MWCNT)/polymer composite films were investigated. In this research, polyethylene oxide (PEO) is used as the polymer matrix. Two representative volume fractions of MWCNT/PEO composite films were selected: 0.56 vol% (near the percolation threshold) and 1.44 vol% (away from the percolation threshold) of MWCNT. An experimental setup which can measure electrical resistance and strain simultaneously and continuously has been developed. Unique and repeatable relationships in resistance versus strain were obtained for multiple specimens with different volume fractions of MWCNT. The overall pattern of electrical resistance change versus strain for the specimens tested consists of linear and nonlinear regions. A resistance change model to describe the combination of linear and nonlinear modes of electrical resistance change as a function of strain is suggested. The unique characteristics in electrical resistance change for different volume fractions imply that MWCNT/PEO composite films can be used as tunable strain sensors and for application into embedded sensor systems in structures.
Automatic Fence Segmentation in Videos of Dynamic Scenes

We present a fully automatic approach to detect and segment fence-like occluders from a video clip. Unlike previous approaches that usually assume either static scenes or cameras, our method is capable of handling both dynamic scenes and moving cameras. Under a bottom-up framework, it first clusters pixels into coherent groups using color and motion features. These pixel groups are then analyzed in a fully connected graph, and labeled as either fence or non-fence using graph-cut optimization. Finally, we solve a dense Conditional Random Filed (CRF) constructed from multiple frames to enhance both spatial accuracy and temporal coherence of the segmentation. Once segmented, one can use existing hole-filling methods to generate a fencefree output. Extensive evaluation suggests that our method outperforms previous automatic and interactive approaches on complex examples captured by mobile devices.
DEVELOPING A VALID AND RELIABLE ATTITUDE SCALE TOWARDS PERSONALIZED LEARNING ENVIRONMENT

The purpose of this study is to develop a valid and reliable attitude scale towards personalized learning in education. To develop an attitude scale, firstly, the item pool has been formed and presented to the experts opinion. Finalized according to the experts opinion, the test form has been conducted on 481 junior and senior students at the Computer Education and Instructional Technologies Education department from six different universities. According to the analyses, confirmatory factor analysis have resulted in KMO value . 95 and Bartlett Sphericity ( =6367.9, .000). Exploratory factor analysis result has also measured up for the acquired form. The value of Cronbach alpha has been calculated as . 95. As a result of the analyses, a valid and reliable personalized learning education attitude scale that consists of one sized and 27 items have been developed.
Exploring Incongruence in Mentoring Dyads in Indian Firms: The Protégé Perspective

Abstract This study seeks to explore whether the negative mentoring experiences (NMEs) of protégés in Western samples are generalizable, or whether there are possibly NMEs unique to the Indian cultural context. The finding of this exploratory study suggests that the most frequently occurring NME for protégés was mismatch in the membership of social group, as per regional, caste or religious orientation. While Western mentoring models are being practised widely in corporate workplaces in India, the process of enculturation and feeling of belonging to an India-specific social group is strong enough to negatively impact mentoring relationships such that these protégés perceive themselves to be “out-group” members. Managers may consider pairing mentors and protégés taking into consideration demographic profiling.
Demographic and Lifestyle Predictors of Prehypertension: A Cross-Sectional Study among Apparently Healthy Adults in Kumasi, Ghana

Background Prehypertension has been shown to increase future risk of hypertension. Some demographic and lifestyle characteristics have been implicated to increase the risk of development of prehypertension. Yet, there is paucity of data on the current prevalence of prehypertension and its associated risk factors in Ghana. This study evaluated the prevalence of prehypertension and examined the demographic and lifestyle characteristics associated with prehypertension among apparently healthy Ghanaian adults in Kumasi. Methods This was a cross-sectional study conducted from March to April, 2018, in Kumasi, Ghana. A total of 204 participants (80 males, 124 females, 25 years and above) who reported not diagnosed of hypertension and not on any antihypertensive medication were included in the study. Validated questionnaire was used to obtain sociodemographic and lifestyle characteristics of study participants. Height and weight of each respondent were measured and their corresponding Body Mass Index (BMI) was calculated. Blood pressure (BP) was measured with an automated blood pressure apparatus from the right arm. Prehypertension was defined as systolic BP of 120-139 mmHg and/or diastolic BP of 80-89 mmHg. Results Out of 204 participants, the prevalence of prehypertension was 49.0%. From multivariate logistic regression models, having lower level of education [aOR=2.74, 95% CI (1.15-6.55), p=0.02], not practicing at least 30 min daily walks [aOR=2.59, 95% CI (1.31-5.10), p=0.01], not exercising routinely [aOR=1.93, 95% CI (0.97-3.85), p=0.04], and alcohol consumption [aOR=3.58(1.52-8.46), p=0.004] were independently associated with higher odds of prehypertension. Conclusion The prevalence of prehypertension is high among apparently healthy Ghanaian adults (49.0%). Lower educational level, sedentary lifestyle, and alcohol consumption are the predominant risk factors for prehypertension in Kumasi.
Exploiting Self-Reported Social Networks for Routing in Ubiquitous Computing Environments

Mobile, delay-tolerant, ad hoc and pocket-switched networks may form an important part of future ubiquitous computing environments. Understanding how to efficiently and effectively route information through such networks is an important research challenge, and much recent work has looked at detecting communities and cliques to determine forwarding paths. Such detected communities, however, may miss important aspects. For instance, a user may have strong social ties to another user that they seldom encounter; a detected social network may omit this tie and so produce sub-optimal forwarding paths. Moreover, the delay in detecting communities may slow the bootstrapping of a new delay-tolerant network. This paper explores the use of self-reported social networks for routing in mobile networks in comparison with detected social networks discovered through encounters. Using encounter records from a group of participants carrying sensor motes, we generate detected social networks from these records. We use these networks for routing, and compare these to the social networks which the users have self-reported on a popular social networking website. Using techniques from social network analysis, we find that the two social networks are different. These differences, however, do not lead to a significant impact on delivery ratio, while the self-reported social network leads to a significantly lower cost.
L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits.

Platelets are capable of producing nitric oxide (NO) through the L-arginine-NO synthase pathway. Acute exposure to supraphysiological concentrations of L-arginine in vitro increases the production of NO by platelets and is associated with an increase in platelet cyclic GMP (cGMP) levels and a reduction in platelet aggregation. The purpose of this study was to determine if chronic oral administration of L-arginine decreases platelet aggregation in hypercholesterolemic animals and to determine if this effect is mediated by the metabolism of L-arginine to NO. Male New Zealand White rabbits were fed normal chow (Con), a 1% cholesterol diet (Chol), or a 1% cholesterol diet supplemented with a sixfold enrichment of dietary L-arginine (Arg) or L-methionine (Met). After 10 weeks, cholesterol levels were equally increased in Chol and Arg animals, whereas plasma arginine levels were doubled in the Arg group. There was no difference in maximum aggregation initiated by ADP (100 mumol/L) between washed platelets from Con, Met, and Chol animals, but aggregation of platelets from Arg animals was significantly decreased (P < .05). In aggregating platelets from Arg animals, cGMP levels were significantly higher than the other groups (P < .05). When platelets were incubated ex vivo with the NO synthase inhibitor NG-monomethyl-L-arginine, the effects of dietary L-arginine were reversed. Chronic dietary supplementation of L-arginine decreases platelet aggregation in hypercholesterolemic rabbits. This effect appears to be due to the metabolism of L-arginine to NO.
A path analysis of the effects of nurses' perceived organizational justice, organizational commitment, and job satisfaction on their turnover intention

Background: Staff turnover, particularly nursing staff turnover, is one of the most common reasons behind loss of productivity in health-care organizations. A basic requirement for reducing staff turnover is to determine its causes. Objectives: This study evaluated the relationships of perceived organizational justice, organizational commitment, and job satisfaction with turnover intention among a group of Iranian hospital nurses. Methods: This cross-sectional study was conducted on nursing staff and auxiliary nurses who were working in 15 teaching hospitals affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. A random sample of nurses, who had an associate or higher degrees in nursing and had a work experience of >1 year, was recruited through stratified random sampling. Data were collected using a demographic questionnaire, the Organizational Justice Questionnaire, the Job Satisfaction Questionnaire, the Organizational Commitment Questionnaire, and the Questionnaire of Turnover and were analyzed through the confirmatory factor analysis, path analysis, Pearson's correlation analysis, and squared multiple correlation analysis. Results: Organizational justice had significant direct relationships with job satisfaction (r = 0.73) and organizational commitment (r = 0.61) and inverse relationship with turnover intention (r = −0.41). Path analysis revealed that organizational justice had no direct effects on turnover intention, while it had indirect effects on turnover intention through the paths of organizational commitment and turnover intention. Conclusion: Nurses' turnover intention is directly affected by organizational commitment and job satisfaction and indirectly affected by organizational justice through the paths of organizational commitment and turnover intention.
An assessment of ICT challenges in rural areas: ICT experts vs rural users views: a case of the Siyakhula Living Lab

Research shows that Information and Communication Technologies (ICTs) can make a significant contribution to economic growth and social development of communities. However, in rural areas there are challenges that appear to slow down the progress and the realisation of the impact of ICTs. These ICT challenges include poor infrastructure, technological illiteracy, high costs of ICTs etc. An assessment of ICT challenges within rural areas was done. A composite methodological approach was employed in this study. This involved the use of qualitative research techniques such as participant observation, workshops, focus groups and individual interviews supported by document analysis. The Siyakhula Living Lab (SLL) in the Eastern Cape Province of South Africa was used as the case study. The paper aims to identify an association between the ICT challenges based on rural ICT users and ICT experts. Two study groups were selected i.e. rural users within SLL, ICT experts in Europe and Africa, government officials and academic institutions were engaged to understand the current ICT challenges in rural areas. Each of the study groups had 50 participants. Chi-square tests were used to test the level of association between each of the challenges. Results show that there are variations in identifying current ICT challenges between SLL rural users and ICT experts. ICT experts mentioned poor ICT infrastructure as the main challenge while this was not what SLL rural users thought. Rather, the SLL community pointed technological illiteracy as the main challenge. The paper aims to show the degree on how each of the ICT challenge was viewed by each of the study groups.
Citation for Published Item: Use Policy Nonlinear Optimal Control Applied to Coordinated Ramp Metering

IEEE transactions on control systems technology. , 12 (6). pp. 920-933. or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that: • a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders. Please consult the full DRO policy for further details. Abstract—The goal of this paper is to describe a generic approach to the problem of optimal coordinated ramp metering control in large-scale motorway networks. In this approach , the traffic flow process is macroscopically modeled by use of a second-order macroscopic traffic flow model. The overall problem of coordinated ramp metering is formulated as a constrained discrete-time nonlinear optimal control problem, and a feasible-direction nonlinear optimization algorithm is employed for its numerical solution. The control strategy's efficiency is demonstrated through its application to the 32-km Amsterdam ring road. A number of adequately chosen scenarios along with a thorough analysis, interpretation, and suitable visualization of the obtained results provides a basis for the better understanding of some complex interrelationships of partially conflicting performance criteria. More precisely, the strategy's efficiency and equitey properties as well as their tradeoff are studied and their partially competitive behavior is discussed. The results of the presented approach are very promising and demonstrate the efficiency of the optimal control methodology for motorway traffic control problems.
Energy utilization and growth performance of chickens fed novel wheat inbred lines selected for different pentosan levels with and without xylanase supplementation

Different F5 recombinant inbred lines from the cross Yumai 34 × Ukrainka were grown in replicated trials on a single site in one harvest year at Rothamsted Research. A total of 10 samples from those lines were harvested and used in a broiler experiment. Twenty nutritionally complete meal-form diets that had 630 g/kg of wheat with different amounts of pentosan, with and without exogenous xylanase supplementation, were used to compare broiler growth performance and determine apparent metabolizable energy corrected for N retention (AMEn). We examined the relationship between the nutritive value of the wheat samples and their chemical compositions and results of quality tests. The amounts of total and water soluble pentosans in wheat samples ranged from 36.7 to 48.0 g/kg DM, and 6.7 to 11.6 g/kg DM, respectively. The mean crude oil and protein contents of the wheat samples were 10.5 and 143.9 g/kg DM, respectively. The average determined value for the kinematic viscosity was 0.0018 mPa.s, and 2.1 mPa.s for the dynamic viscosity. The AMEn of the wheat-based diets had a maximum range of 0.47 MJ/kg DM within the ten wheat samples that were tested. Xylanase supplementation improved (P < 0.05) dietary AMEn, dry matter, and fat digestibility coefficients. There was a positive (P < 0.05) relationship between in vitro kinematic viscosity of the wheat samples and the total pentosan content. There was a negative relationship between the total pentosan content in the wheat and broiler growth performance. An increase by 10 g of pentosan per kg of wheat reduced (P < 0.001) daily feed intake and weight gain by 2.9 g and 3.5 g, respectively. The study shows that the feeding quality of wheat samples can be predicted by their total pentosan content. Supplementary xylanase improved energy and nutrient availability of all wheat samples that was independent of differences in pentosan content.
Modeling human eye behavior during mammographic scanning: preliminary results

We investigate the use of an inexpensive and unobtrusive eye-tracking system to explore relationships between visual scanning patterns, pupillary response, and the clinical diagnoses of mammographic experts. One radiologist and three radiological technicians each examined a series of 14 mammograms for indications of abnormalities associated with breast cancer. The status of each mammogram was verified by biopsy. The eye-tracking system was used to measure and record eye position and pupil diameter as a function of time as the subjects scanned the mammograms. Three treatments were applied to the scan data to model the experts' eye behaviors. These included quantification of dwell time and pupil diameter as a function diagnostic accuracy in regions of the mammogram where abnormalities existed or were perceived; independent clustering of lookpoints without respect to abnormalities; and analysis of scan transitions between lookpoint clusters. Results of the analysis were consistent with extensive prior studies of eye-scan measures recorded during the diagnosis of abnormalities on chest radiograms. This preliminary investigation provides a proof of concept for use of the eye-tracking technology, experimental protocols, and analysis methodologies as the basis for expanded mammographic studies, with the promise of eventual adaptation as a source of diagnostic information in clinical practice.
Chlamydia trachomatis Infections in Female Soldiers, Israel

We examined the prevalence of Chlamydia trachomatis infection in Israeli female soldiers. The prevalence was 3.2% among soldiers seeking medical care; rural residence was identified as a significant risk factor. Nevertheless, given the study design, recommending broad-scale screening of Israeli female soldiers may be premature.2
Effect of Intensive Lifestyle Intervention on Sexual Dysfunction in Women With Type 2 Diabetes

OBJECTIVE Sexual dysfunction is a prevalent problem in obese women with type 2 diabetes. This study examined the effects of intensive lifestyle intervention (ILI) in these women. RESEARCH DESIGN AND METHODS Look AHEAD is a 16-center, randomized, controlled trial evaluating the health effects of ILI compared with a control group (diabetes support and education [DSE]). The Look AHEAD Sexual Function Ancillary study included 375 female participants at five Look AHEAD sites. Participants completed the Female Sexual Function Inventory (FSFI) and Beck Depression Inventory (BDI), and assessments of weight and cardiovascular risk factors at baseline and 1 year were made. RESULTS At baseline, 50% of the 229 participants who reported being sexually active met criteria for female sexual dysfunction (FSD); only BDI score was related to FSD. One-year weight losses were greater in the ILI group than in the DSE group (7.6 vs. 0.45 kg; P < 0.001). Among women with FSD at baseline, those in the ILI group (N = 60) compared with those in the DSE group (N = 53) were significantly more likely to remain sexually active (83 vs. 64%; P < 0.008), reported greater improvement in total FSFI scores and in most FSFI domains (P < 0.05), and were more likely to experience remission of FSD (28 vs. 11%; P < 0.04) at 1 year. No significant differences between ILI and DSE were seen in women who did not have FSD at baseline. CONCLUSIONS Participation in ILI appeared to have beneficial effects on sexual functioning among obese women with diabetes, particularly in those who had FSD at baseline.
Local product structure for Equilibrium States

The usual way to study the local structure of Equilibrium State of an AxiomA diffeomorphism or flow is to use the symbolic dynamic and to push results on the manifold. A new geometrical method is given. It consists in proving that Equilibrium States for Holder-continuous functions are related to other Equilibrium States of some special sub-systems satisfying a sort of expansiveness. Using different kinds of extensions the local product structure of Gibbs-measure is proven.