Miracle-dz/UniFAR-FTUs huggingface dataset:
WNT4 acts downstream of BMP2 to mediate the regulation of ATRA signaling on RUNX1 expression: Implications for terminal differentiation of antler chondrocytes

Although ATRA is involved in regulating the proliferation and differentiation of chondrocytes, its underlying mechanism remains unknown. Here we showed that ATRA could stimulate the proliferation of antler chondrocytes and expression of COL X and MMP13 which were two well‐known markers for hypertrophic chondrocytes. Silencing of CRABP2 prevented the induction of ATRA on chondrocyte terminal differentiation, while overexpression of CRABP2 exhibited the opposite effects. CYP26A1 and CYP26B1 weakened the sensitivity of antler chondrocytes to ATRA. Further analysis evidenced that ATRA might induce chondrocyte terminal differentiation and modulate the expression of BMP2, WNT4, and RUNX1 through RARα/RXRα. Knockdown of BMP2 enhanced the induction of ATRA on the expression of COL X and MMP13, whereas overexpression of BMP2 abrogated this effectiveness. WNT4 might mediate the effects of ATRA and BMP2 on chondrocyte terminal differentiation. Dysregulation of BMP2 impaired the regulation of ATRA on WNT4 expression. Administration of ATRA to antler chondrocytes transfected with RUNX1 siRNA failed to induce the differentiation. Conversely, rRUNX1 strengthened the stimulation of ATRA on the expression of COL X and MMP13. Simultaneously, RUNX1 was a downstream effector of BMP2 and WNT4 in chondrocyte terminal differentiation. Moreover, WNT4 might play an important role in the crosstalk between BMP2 and RUNX1. Attenuation of BMP2 or WNT4 enhanced the interaction between ATRA and RUNX1, while constitutive expression of BMP2 or WNT4 reversed the regulation of ATRA on RUNX1. Collectively, WNT4 may act downstream of BMP2 to mediate the effects of ATRA on the terminal differentiation of antler chondrocytes through targeting RUNX1.
Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemia

The distinct effects of different statins on glycemic control have not been fully evaluated. In this open‐label, prospective, cross‐over clinical trial, we compared the effects of pitavastatin and atorvastatin on glycemic control in type 2 diabetic patients with hypercholesterolemia.
Multitime maximum principle for curvilinear integral cost

Recently we have created a multitime maximum principle gath- ering together some concepts in Mechanics, Field Theory, Difierential Ge- ometry, and Control Theory. The basic tools of our theory are variational PDE systems, adjoint PDE systems, Hamiltonian PDE systems, duality, multitime maximum principle, incavity on manifolds etc. Now we jus- tify the multitime maximum principle for curvilinear integral cost using the m-needle variations. Section 1 recalls the multitime control theory and proves the equivalence between curvilinear integral costs and multi- ple integral costs. Section 2 formulates variants of multitime maximum principle using control Hamiltonian 1-forms produced by a curvilinear in- tegral cost and a controlled m-∞ow evolution. Section 3 refers to original proofs of the multitime maximum principle using simple and multiple mul- titime m-needle control variations. The key is to use completely integrable flrst order PDEs (controlled evolution and variational PDEs) and their ad- joint PDEs. Section 4 formulates and proves su-cient conditions that the multitime maximum principle be true.
An Evaluation of Satellite Remote Sensing Data Products for Land Surface Hydrology: Atmospheric Infrared Sounder*

Abstract The skill of instantaneous Atmospheric Infrared Sounder (AIRS) retrieved near-surface meteorology, including surface skin temperature (Ts), air temperature (Ta), specific humidity (q), and relative humidity (RH), as well as model-derived surface pressure (Psurf) and 10-m wind speed (w), is evaluated using collocated National Climatic Data Center (NCDC) in situ observations, offline data from the North American Land Data Assimilation System (NLDAS), and geostationary remote sensing (RS) data from the Spinning Enhanced Visible and Infrared Imager (SEVIRI). Such data are needed for RS-based water cycle monitoring in areas without readily available in situ data. The study is conducted over the continental United States and Africa for a period of more than 6 years (2002–08). For both regions, it provides for the first time the geographic distribution of AIRS retrieval performance. Through conditional sampling, attribution of retrieval errors to scene atmospheric and surface conditions is performed. Th.
3-year follow-up of the NIMH MTA study.

OBJECTIVE In the intent-to-treat analysis of the Multimodal Treatment Study of Children With ADHD (MTA), the effects of medication management (MedMgt), behavior therapy (Beh), their combination (Comb), and usual community care (CC) differed at 14 and 24 months due to superiority of treatments that used the MTA medication algorithm (Comb+MedMgt) over those that did not (Beh+CC). This report examines 36-month outcomes, 2 years after treatment by the study ended. METHOD For primary outcome measures (attention-deficit/hyperactivity disorder [ADHD] and oppositional defiant disorder [ODD] symptoms, social skills, reading scores, impairment, and diagnostic status), mixed-effects regression models and orthogonal contrasts examined 36-month outcomes. RESULTS At 3 years, 485 of the original 579 subjects (83.8%) participated in the follow-up, now at ages 10 to 13 years, (mean 11.9 years). In contrast to the significant advantage of MedMgt+Comb over Beh+CC for ADHD symptoms at 14 and 24 months, treatment groups did not differ significantly on any measure at 36 months. The percentage of children taking medication >50% of the time changed between 14 and 36 months across the initial treatment groups: Beh significantly increased (14% to 45%), MedMed+Comb significantly decreased (91% to 71%), and CC remained constant (60%-62%). Regardless of their treatment use changes, all of the groups showed symptom improvement over baseline. Notably, initial symptom severity, sex (male), comorbidity, public assistance, and parental psychopathology (ADHD) did not moderate children's 36-month treatment responses, but these factors predicted worse outcomes over 36 months, regardless of original treatment assignment. CONCLUSIONS By 36 months, the earlier advantage of having had 14 months of the medication algorithm was no longer apparent, possibly due to age-related decline in ADHD symptoms, changes in medication management intensity, starting or stopping medications altogether, or other factors not yet evaluated.
Rhinovirus infections in an industrial population. I. The occurrence of illness.

RHINOVIRUSES have been associated with 10 to 30 per cent of acute upper respiratory illnesses in several groups of adults.1 2 3 4 5 6 In March, 1963, a study was undertaken to define the etiology and epidemiology of acute respiratory disease in a population of working adults, and the role of a number of viruses was studied initially. Coincident with the beginning of the investigation, improvements in technology occurred that facilitated the isolation of rhinoviruses and shifted emphasis to these agents. During the first three years of the study, the period considered in this report, approximately a quarter of the acute respiratory illnesses were .
Two‐dimensional, Non‐Doppler Strain Imaging during Anesthesia and Cardiac Surgery

Transesophageal echochardiography (TEE) has become an essential intraoperative monitor during general anesthesia for cardiac surgical procedures. In clinical practice, ventricular function is visually evaluated using gray scale and Doppler modes, despite the fact that subjective interpretation is influenced by level of experience and training. Echocardiographic strain imaging measures cardiac deformation and provides objective quantification of regional myocardial function. Non‐Doppler strain, which is derived by tracking speckles from two‐dimensional (2D) images, bypasses the limitations of Doppler‐based strain measurements and evaluates the complex myocardial deformation along three dimensions. As a result, longitudinal shortening, circumferential thinning and radial thickening can be quantified using standard midesophageal and transgastric views, being acquired during a comprehensive TEE examination. Once non‐Doppler strain becomes available on “real time,” it will have the potential to become a valuable tool for detection of ischemia on the regional level and objective quantification of global ventricular function.
Balanced Distribution Adaptation for Transfer Learning

Transfer learning has achieved promising results by leveraging knowledge from the source domain to annotate the target domain which has few or none labels. Existing methods often seek to minimize the distribution divergence between domains, such as the marginal distribution, the conditional distribution or both. However, these two distances are often treated equally in existing algorithms, which will result in poor performance in real applications. Moreover, existing methods usually assume that the dataset is balanced, which also limits their performances on imbalanced tasks that are quite common in real problems. To tackle the distribution adaptation problem, in this paper, we propose a novel transfer learning approach, named as Balanced Distribution Adaptation (BDA), which can adaptively leverage the importance of the marginal and conditional distribution discrepancies, and several existing methods can be treated as special cases of BDA. Based on BDA, we also propose a novel Weighted Balanced Distribution Adaptation (W-BDA) algorithm to tackle the class imbalance issue in transfer learning. W-BDA not only considers the distribution adaptation between domains but also adaptively changes the weight of each class. To evaluate the proposed methods, we conduct extensive experiments on several transfer learning tasks, which demonstrate the effectiveness of our proposed algorithms over several state-of-the-art methods.
Cancer Immunotherapy: A Future Paradigm Shift in the Treatment of Non–Small Cell Lung Cancer

Emerging evidence on the role of the antitumor activity of the immune system has generated great interest in immunotherapy even for tumors that were historically considered as nonimmunogenic. Immunotherapy is emerging as a major modality in non–small cell lung cancer (NSCLC) treatment focusing on vaccine approaches to elicit specific immune responses and development of inhibitors of the molecular mediators of cancer-induced immunosuppression (immune checkpoints) to boost antitumor immune responses. Amplification of the host response against evolving tumors through vaccination is being investigated in ongoing clinical trials with tumor cell vaccines; however, the clinical efficacy of these agents has been limited. Blocking inhibitory pathways such as the CTL antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) checkpoint pathways with mAbs has generated antitumor immune responses that are transforming cancer therapeutics. PD-1 and programmed cell death ligand 1 (PD-L1) antibodies have shown durable responses in NSCLC, with a favorable safety profile and manageable side effects. The activity of immune checkpoint inhibitors is currently been assessed in treatment-naïve patients with PD-L1–positive advanced NSCLC. Combinatorial approaches with other immune checkpoint inhibitors, chemotherapy, or targeted agents are being explored in ongoing clinical trials, and may improve outcome in NSCLC. Clin Cancer Res; 21(5); 976–84. ©2015 AACR.
A Decidable Timeout based Extension of Propositional Linear Temporal Logic

We develop a timeout based extension of propositional linear temporal logic (which we call TLTL) to specify timing properties of timeout based models of real time systems. TLTL formulas explicitly refer to a running global clock together with static timing variables as well as a dynamic variable abstracting the timeout behavior. We extend LTL with the capability to express timeout constraints. From the expressiveness view point, TLTL is not comparable with important known clock based real-time logics including TPTL, XCTL, and MTL, i.e., TLTL can specify certain properties, which cannot be specified in these logics (also vice-versa). We define a corresponding timeout tableau for satisfiability checking of the TLTL formulas. Also a model checking algorithm over timeout Kripke structure is presented. Further we prove that the validity checking for such an extended logic remains PSPACE-complete even in the presence of timeout constraints and infinite state models. Under discrete time semantics, with bounded timeout increments, the model-checking problem that if a TLTL-formula holds in a timeout Kripke structure is also PSPACE complete. We further prove that when TLTL is interpreted over discrete time, it can be embedded in the monadic second order logic with time, and when TLTL is interpreted over dense time without the condition of non-zenoness, the resulting logic becomes $\Sigma_1^1$-complete.
Surgical Outcomes of Cerebellopontine angle Tumors in 50 Cases

Introduction: To report our experience with a large series of surgical procedures for removal of cerebellopontine angle (CPA) tumors using different approaches. Materials and Methods: This was a retrospective analysis of 50 patients (mean age, 49 years) with CPA tumors (predominantly acoustic neuroma) who underwent surgical removal using appropriate techniques (principally a translabyrinthine approach) during a 4-year period. Results: One death occurred during this study. There were nine cases (18%) of cerebrospinal fluid leak, and five patients (10%) were diagnosed as having bacterial meningitis. Complete gross tumor removal was not achieved in four patients (8%). Facial nerve function as measured by the House Brackmann system was recorded in all patients 1 year following surgery: 32% had a score of 1 or 2; 26% had a score of 3 or 4; and 8% had a score of 5 or 6. Other complications included four cases of wound infection. Conclusion: The translabyrinthine approach was predominantly used in our series of CPA tumors, and complication rates were comparable with other large case series.
The Meteoritical Bulletin, No. 82, 1998 July

Abstract— Meteoritical Bulletin No. 82 lists information for 974 new meteorites, including 521 finds from Antarctica, 401 finds from the Sahara, 21 finds from the Nullarbor region of Australia, and 7 falls (Ban Rong Du, Burnwell, Fermo, Jalanash, Juancheng, Monahans (1998), and Silao). Many rare types of meteorites are reported: counting pairing groups as one, these include one CR chondrite, two CK chondrites, two CO chondrites, four CV chondrites, one CH chondrite or Bencubbin‐like, six C2 (unclassified) chondrites, two EH chondrites, two EL chondrites, three R chondrites, thirty unequilibrated ordinary chondrites, one un‐grouped chondrite, three eucrites, six howardites, one diogenite, eleven ureilites, nine iron meteorites, one mesosiderite, two brachinites, one lodranite, one winonaite, and two lunar meteorites (Dar al Gani 400 and EET 96008). All italicized abbreviations refer to addresses tabulated at the end of this document.
Illusory Control

Three experiments demonstrated that the experience of power leads to an illusion of personal control. Regardless of whether power was experientially primed (Experiments 1 and 3) or manipulated through roles (manager vs. subordinate; Experiment 2), it led to perceived control over outcomes that were beyond the reach of the power holder. Furthermore, this illusory control mediated the influence of power on several self-enhancement and approach-related outcomes reported in the power literature, including optimism (Experiment 2), self-esteem (Experiment 3), and action orientation (Experiment 3). These results demonstrate the theoretical importance of perceived control as a generative cause of and driving force behind many of power's far-reaching effects. A fourth experiment ruled out an alternative explanation: that positive mood, rather than illusory control, is at the root of power's effects. The discussion considers implications for existing and future research on the psychology of power, perceived control, and positive illusions.
40Ar/39Ar and K-Ar geochronology and tectonic significance of the Upper Cretaceous Adel Mountain volcanics and spatially associated Tertiary igneous rocks, northwestern Montana

We report new 40 Ar/ 39 Ar and K-Ar dates from the Upper Cretaceous Adel Mountain Volcanics of northwestern Montana and spatially related Tertiary igneous rocks. The Adel Mountain volcanic field consists of about 900 square kilometers of lavas, associated volcaniclastic strata, and intrusions that lie astride the easternmost folds of the Montana disturbed belt of the Cordilleran fold and thrust belt. The Adel Mountain volcanic rocks have been intensely deformed by folds and thrust faults along their southwestern margin but are essentially undeformed to the east. Prior to isotopic dating, the age of the Adel Mountain Volcanics was the subject of debate, with age assignments ranging from Late Cretaceous to early Tertiary. Isotopic dates reported here demonstrate that the Adel Mountain Volcanics are clearly Late Cretaceous and that the volcanic rocks were probably emplaced during an approximately 2-to 3-mill ion-year interval between about 76 to 73 mega-annum (Ma). The new dates from the Adel Mountain Volcanics are significant in that they provide a more refined and reliable age for the Late Cretaceous cratonic paleomagnetic reference pole for North America. The dates from the Adel Mountain Volcanics, as well as those from spatially related younger intrusions, also provide important constraints on the age of fold and thrust-belt deformation along the eastern margin of the Montana disturbed belt. Syntectonic deformation of the Adel Mountain Volcanics, as well as apparent folding and faulting of Tertiary quartz monzonite sills, indicates that contractional deformation clearly spanned the Late Cretaceous and may have extended to as young as the Paleocene/Eocene boundary at about 55.5 Ma. Elsewhere, posttectonic field relationships indicate that deformation may have ended prior to 60 Ma. Complexities in field relationships with respect to folds and faults shown by the early Tertiary intrusions as well as complications in the argon systematics indicate that these interpretations must be considered preliminary. Further field work and structural studies and additional high-precision geochronology are needed in order to place limits on the cessation of contractional deformation in this part of Montana. Unambiguously posttectonic dikes (47.5 Ma) that cut all deformed rocks and structures in the area indicate that disturbed belt deformation had clearly ceased by the early middle Eocene prior to the onset of widespread crustal extension in this part of the northern Cordillera.
Hierarchical evolution of neural networks

In most applications of neuro-evolution, each individual in the population represents a complete neural network. Recent work on the SANE system, however, has demonstrated that evolving individual neurons often produces a more efficient genetic search. This paper demonstrates that while SANE can solve easy tasks very quickly, it often stalls in larger problems. A hierarchical approach to neuro-evolution is presented that overcomes SANE's difficulties by integrating both a neuron-level exploratory search and a network-level exploitive search. In a robot arm manipulation task, the hierarchical approach outperforms both a neuron-based search and a network-based search.
The crystal structure of Mg end-member lizardite-1T forming polyhedral spheres from the Lizard, Cornwall

Abstract The crystal structure of lizardite-1T from Gew-graze, Cornwall, has been refined by single-crystal X-ray diffractionto R1 of 0.0263 and 0.0557, for two crystals having P31m space group and lattice parameters a = 5.2905(5) Å, c = 7.2815(8) Å, and a = 5.3111(10) Å, c = 7.2907(15) Å, respectively. The Gew-graze lizardite is very close to the end-member composition, so these refinements confirm the existence of well crystallized pure Mg-lizardite and show this to be the most weakly H-bonded lizardite ever refined. With regard to its lattice parameters, Si−O bond distances and geometrical parameters controlled by interlayer interactions (i.e. H-bonding), the Gew-graze Mg end-member lizardite yields slight but observable geometrical differences compared with previous refined structures for specifically, aluminous, lizardites.
Estimation of excitation forces for wave energy converters control using pressure measurements

ABSTRACT Most control algorithms of wave energy converters require prediction of wave elevation or excitation force for a short future horizon, to compute the control in an optimal sense. This paper presents an approach that requires the estimation of the excitation force and its derivatives at present time with no need for prediction. An extended Kalman filter is implemented to estimate the excitation force. The measurements in this approach are selected to be the pressures at discrete points on the buoy surface, in addition to the buoy heave position. The pressures on the buoy surface are more directly related to the excitation force on the buoy as opposed to wave elevation in front of the buoy. These pressure measurements are also more accurate and easier to obtain. A singular arc control is implemented to compute the steady-state control using the estimated excitation force. The estimated excitation force is expressed in the Laplace domain and substituted in the control, before the latter is transformed to the time domain. Numerical simulations are presented for a Bretschneider wave case study.
Burden of Cardiovascular Risk Factors, Subclinical Atherosclerosis, and Incident Cardiovascular Events Across Dimensions of Religiosity: The Multi-Ethnic Study of Atherosclerosis

Background— Religious involvement has been associated with improved health practices and outcomes; however, no ethnically diverse community-based study has examined differences in cardiac risk factors, subclinical cardiovascular disease, and cardiovascular disease (CVD) events across levels of religiosity. Methods and Results— We included 5474 white, black, Hispanic, and Chinese participants who attended examination 2 of the National Heart, Lung, and Blood Institute's Multi-Ethnic Study of Atherosclerosis (MESA). We compared cross-sectional differences in cardiac risk factors and subclinical CVD and longitudinal CVD event rates across self-reported levels of religious participation, prayer/meditation, and spirituality. Multivariable-adjusted regression models were fitted to assess associations of measures of religiosity with risk factors, subclinical CVD, and CVD events. MESA participants (52.4% female; mean age, 63) with greater levels of religious participation were more likely to be female and black. After adjustment for demographic covariates, participants who attended services daily, compared with never, were significantly more likely to be obese (adjusted odds ratio 1.57, 95% confidence interval [CI] 1.12 to 1.72) but less likely to smoke (adjusted odds ratio 0.39, 95% CI 0.26 to 0.58). Results were similar for those with frequent prayer/meditation or high levels of spirituality. There were no consistent patterns of association observed between measures of religiosity and presence/extent of subclinical CVD at baseline or incident CVD events during longitudinal follow-up in the course of 4 years. Conclusions— Our results do not confirm those of previous studies associating greater religiosity with overall better health risks and status, at least with regard to CVD. There was no reduction in risk for CVD events associated with greater religiosity.