Miracle-dz/UniFAR-FTUs huggingface dataset:
A Brainstem Network Mediating Apneic Reflexes in the Rat

Apnea is an important protective response to upper airway irritation, but the central mechanisms responsible for eliciting sensory-induced apnea are not well understood. Recent studies have emphasized the Kölliker-Fuse nucleus in producing apnea and proposed a trigeminoparabrachial pathway for mediating these reflexes. However, in our earlier study of apneic responses produced by glutamate stimulation in the dorsolateral pons, we found that apnea was elicited from the area just ventral to the Kölliker-Fuse nucleus, rather than within it. Because this region was not known to be involved in respiratory control, we combined chemical microstimulation with both anterograde and retrograde axonal tracing to characterize the sites in the pons that produce apneic responses. We found that apneic sites were consistently associated with the intertrigeminal region, between the principal sensory and motor trigeminal nuclei. Injections of anterograde tracer at these sites labeled terminals in the ventral respiratory group, in the ventrolateral medulla. Injection of retrograde tracer into this target region in the ventrolateral medulla disclosed a previously unrecognized population of neurons among the trigeminal motor rootlets. Injection of retrograde tracer into this intertrigeminal region demonstrated inputs from portions of the spinal trigeminal nucleus and the nucleus of the solitary tract that have been associated with producing sensory apnea. Our observations suggest that the intertrigeminal region receives a convergence of sensory inputs capable of driving apneic responses and that it may represent a common link between input from different portions of the airway and the respiratory neurons that mediate apneic reflexes.
Antiidiotypic DNA vaccination induces serum bactericidal activity and protection against group B meningococci

No vaccine is available for preventing infections by serogroup B Neisseria meningitidis (MenB), which accounts for a major portion of meningococcal cases in developed countries, because of the poor immunogenicity of the capsular polysaccharide (CP) even after protein conjugation. We have previously induced anticapsular antibodies by immunization with a single chain variable fragment (scFv), which mimics a protective CP epitope. This surrogate antigen, however, was ineffective at inducing serum bactericidal activity, an accepted marker of protection in humans. Serum bactericidal activity was consistently achieved by immunizing mice with the scFv-encoding gene. Immunization with vectors without a secretory signal sequence before the scFv resulted in markedly higher bactericidal activity relative to those with such a sequence. The induced antibodies were capsule specific, as shown by complete inhibition of bactericidal activity by purified MenB CP and by resistance to killing of MenA or MenC. Moreover, these antibodies were predominantly of the IgG2a isotype, reflecting a T helper type 1 response. Administration of sera from scFv gene–vaccinated animals protected infant rats against MenB bacteremia. These data illustrate the potential of vaccination with genes encoding capsular mimics in providing protection against MenB and other encapsulated bacteria.
Targeting the circulating microRNA signature of obesity.

BACKGROUND Genomic studies have yielded important insights into the pathogenesis of obesity. Circulating microRNAs (miRNAs) are valuable biomarkers of systemic diseases and potential therapeutic targets. We sought to define the circulating pattern of miRNAs in obesity and examine changes after weight loss. METHODS We assessed the genomewide circulating miRNA profile cross-sectionally in 32 men and after surgery-induced weight loss in 6 morbidly obese patients. The most relevant miRNAs were cross-sectionally validated in 80 men and longitudinally in 22 patients (after surgery-induced weight loss). We evaluated the effects of diet-induced weight loss in 9 obese patients. Thirty-six circulating miRNAs were associated with anthropometric variables in the initial sample. RESULTS In the validation study, morbidly obese patients showed a marked increase of miR-140-5p, miR-142-3p (both P < 0.0001), and miR-222 (P = 0.0002) and decreased levels of miR-532-5p, miR-125b, miR-130b, miR-221, miR-15a, miR-423-5p, and miR-520c-3p (P < 0.0001 for all). Interestingly, in silico targets leukemia inhibitory factor receptor (LIFR) and transforming growth factor receptor (TGFR) of miR-140-5p, miR-142-3p, miR-15a, and miR-520c-3p circulated in association with their corresponding miRNAs. Moreover, a discriminant function of 3 miRNAs (miR-15a, miR-520c-3p, and miR-423-5p) was specific for morbid obesity, with an accuracy of 93.5%. Surgery-induced (but not diet-induced) weight loss led to a marked decrease of miR-140-5p, miR-122, miR-193a-5p, and miR-16-1 and upregulation of miR-221 and miR-199a-3p (P < 0.0001 for all). CONCLUSIONS Circulating miRNAs are deregulated in severe obesity. Weight loss-induced changes in this profile and the study of in silico targets support this observation and suggest a potential mechanistic relevance.
Interaction-induced star formation in a complete sample of 105 nearby star-forming galaxies

We investigate the clustering properties of a complete sample of 10 5 star-forming galaxies drawn from the data release 4 (DR4) of the Sloan Digital Sky Survey. On scales less than 100 kpc, the amplitude of the correlation function exhibits a strong dependence on the specific star formation rate (SSFR) of the galaxy. We interpret this as the signature of enhanced star formation induced by tidal interactions. We then explore how the average star formation rate (SFR) in a galaxy is enhanced as the projected separation rp between the galaxy and its companions decreases. We find that the enhancement strongly depends on rp, but very weakly on the relative luminosity of the companions. The enhancement is also stronger in low-mass galaxies than in high-mass galaxies. In order to explore whether a tidal interaction is not only sufficient, but also necessary to trigger enhanced star formation in a galaxy, we compute background subtracted neighbour counts for the galaxies in our sample. The average number of close neighbours around galaxies with low to average values of SFR/M∗ is close to zero. At the highest SSFRs, however, more than 40 per cent of the galaxies in our sample have a companion within a projected radius of 100 kpc. Visual inspection of the highest SFR/M∗ galaxies without companions reveals that more than 50 per cent of these are clear interacting or merging systems. We conclude that tidal interactions are the dominant trigger of enhanced star formation in the most strongly star-forming systems. Finally, we find clear evidence that tidal interactions not only lead to enhanced star formation in galaxies, but also cause structural changes such as an increase in concentration.
The long-term X-ray variability properties of AGNs in the Lockman Hole region

Context. We present the results from a detailed X-ray variability analysis of 66 AGN in the Lockman Hole, which have optical spectroscopic identifications. Aims. We compare, quantitatively, their variability properties with the properties of local AGN, and we study the “variability – luminosity” relation as a function of redshift, and the “variability – redshift” relation in two luminosity bins. Methods. We use archival data from the last 10 XMM-Newton observations of the Lockman Hole field to extract light curves for the rest frame 2–10 keV band. We use the “normalized excess variance” to quantify the variability amplitude. Using the results about the AGN power spectral shape and its dependence on black hole mass and accretion rate, we are able to compute model “variability – luminosity” curves, which we compare with the relations that we observe. Results. When we consider all the sources in our sample, we find that their variability amplitude decreases with increasing redshift and luminosity. These global anti-correlations become weaker when we split the objects into various luminosity and redshift bins. We do not find a significant correlation between variability amplitude and spectral slope, Γ . We measure a “variability – luminosity” relation that has a larger amplitude that for local AGN. At a given luminosity we also find that the variability amplitude increases with redshift up to $z\sim 1$, and then remains approximately constant. Conclusions. Our results imply that the AGN X-ray mechanism operates in the same way at all redshifts. The accretion rate (in units of the Eddington limit) for the objects in our sample increases from ∼ 0.25, at $z \sim 0.5$, to 0.5 at $z \sim 3$. It does not exceed unity even in the case of the most luminous AGN. Their black hole mass also increases with redshift. The upper limit we find is consistent with the largest black hole masses found to date in the local Universe. The increase in the black hole mass, and the decrease in the rest frame light curve duration with increasing redshift, can explain the global variability amplitude – redshift/luminosity anti-correlations that we observe. For objects of similar luminosity, the black hole mass decreases and the accretion rate increases as the redshift becomes higher. This effect explains the increase in the variability amplitude up to redshift ~ 1 (at fixed luminosity bins). At higher redshifts, the decrease in the light curves duration affects the variability amplitude significantly, forcing it to remain essentially constant.
Disparities in A1C Levels Between Hispanic and Non-Hispanic White Adults With Diabetes

OBJECTIVE—Hispanics have higher rates of diabetes and diabetes-related complications than do non-Hispanic whites. A meta-analysis was conducted to estimate the difference between the mean values of A1C for these two groups. RESEARCH DESIGN AND METHODS—We executed a PubMed search of articles published from 1993 through July 2007. Data sources included PubMed, Web of Science, Cumulative Index to Nursing and Allied Health, the Cochrane Library, Combined Health Information Database, and Education Resources Information Center. Data on sample size, age, sex, A1C, geographical location, and study design were extracted. Cross-sectional data and baseline data from clinical trials and cohort studies for Hispanics and non-Hispanic whites with diabetes were included. Studies were excluded if they included individuals <18 years of age or patients with pre-diabetes or gestational diabetes. RESULTS—A total of 495 studies were reviewed, of which 73 contained data on A1C for Hispanics and non-Hispanic whites, and 11 met the inclusion criteria. Meta-analysis revealed a statistically significant mean difference (P < 0.0001) of −0.46 (95% CI −0.63 to −0.33), correlating to an ∼0.5% higher A1C for Hispanics. Grouping studies by design (cross-sectional or cohort), method of data collection for A1C (chart review or blood sampling), and care type (managed or nonmanaged) yielded similar results. CONCLUSIONS—In this meta-analysis, A1C was ∼0.5% higher in Hispanic patients with diabetes than in non-Hispanic patients. Understanding the reasons for this disparity should be a focus for future research.
Linguistic Summarization of Trends : A Fuzzy Logic Based Approach

The purpose of this paper is to propose a new easily implementable approach to a linguistic summarization of trends that may be present in temporal data. It is based on fuzzy linguistic summaries of data (databases) in the sense of Yager (cf. Yager [20], Kacprzyk and Yager [9], and Kacprzyk, Yager and Zadrożny [10]) which in the form of natural language-like sentences subsume the very essence of a set of data.
Clinicoradiological Spectrum of Reversible Splenial Lesion Syndrome (RESLES) in Adults

AbstractThe presence of reversible lesions that involve the splenium of the corpus callosum (SCC) has been reported in patients with a broad spectrum of diseases and conditions and is referred to as reversible splenial lesion syndrome (RESLES). To describe the clinicoradiological features and establish a clinical position for this disease, we retrospectively examined the clinicoradiological features of adult RESLES patients, as well as discuss the potential pathophysiological mechanisms of this disease.The clinical and MRI findings of patients who presented with RESLES accompanied by symptoms of neurological disorders were retrospectively reviewed. The patients were classified into 2 subgroups (favorable and poor outcome subgroups), which corresponded to the severity of the disability using the Modified Oxford Handicap Scale. In addition, we compared the clinical and neuroimaging features between the 2 outcome subgroups.Eight patients with RESLES associated with various diseases and conditions were included. The clinical presentation was nonspecific; however, MRI exhibited consistent lesions in the SCC with a hypointensity on apparent diffusion coefficient maps and a hyperintensity via diffusion-weighted imaging, which disappeared after a variable lapse. The number of patients with a severe disturbance of consciousness, extracallosal lesions, or diffuse slow waves in the poor outcome subgroup was significantly increased compared with the favorable outcome subgroup (P < 0.05). Thus, the clinicoradiological spectrum of RESLES could be classified into 2 principal categories according to differential outcomes.RESLES is a rare entity with a broad clinicoradiological spectrum because of the various diseases and conditions. Although the overall symptoms of RESLES patients tend to be alleviated, the prognosis of patients with a severe disturbance of consciousness, extracallosal lesions, or diffuse slow waves is likely unfavorable.
Trade Imbalances and the Political Economy of a Transitional Fund in the Eac

The EAC is on the verge of establishing a customs union. But this is accompanied by fears that the Customs Union would lead to trade imbalances among the Partner States, which would create serious problems for the proper functioning of the Customs Union itself. To mitigate these problems the establishment of a transitional fund is proposed. Based on a study of the trade effects of the Customs Union it is shown that these fears are unfounded, and the establishment of a transitional fund to address imbalances therefore not necessary. Stakeholders views on the establishment of a transitional fund are also analysed to assess their influence on the integration policy in the EAC. The historical background of the fears of a customs union is described and it is shown how these fears continue to present time, in spite of changing economic conditions.
The role of sphingolipid signalling in diabetes-associated pathologies (Review)

Sphingosine kinase (SphK) is an important signalling enzyme that catalyses the phosphorylation of sphingosine (Sph) to form sphingosine-1-phosphate (S1P). The multifunctional lipid, S1P binds to a family of five G protein-coupled receptors (GPCRs). As an intracellular second messenger, S1P activates key signalling cascades responsible for the maintenance of sphingolipid metabolism, and has been implicated in the progression of cancer, and the development of other inflammatory and metabolic diseases. SphK and S1P are critical molecules involved in the regulation of various cellular metabolic processes, such as cell proliferation, survival, apoptosis, adhesion and migration. There is strong evidence supporting the critical roles of SphK and S1P in the progression of diabetes mellitus, including insulin sensitivity and insulin secretion, pancreatic β-cell apoptosis, and the development of diabetic inflammatory state. In this review, we summarise the current state of knowledge for SphK/S1P signalling effects, associated with the development of insulin resistance, pancreatic β-cell death and the vascular complications of diabetes mellitus.
What Are the Ingredients for an Inequity Paradigm? Manipulating the Experimenter's Involvement in an Inequity Task with Dogs

Cooperation is only beneficial if the outcome is equally shared between individuals involved in the cooperative interaction. A mechanism to limit the development of unequal cooperation is inequity aversion, the negative reaction to unequal treatment. While inequity aversion has been studied extensively across many animal species, it remains unclear whether inequity aversion elicited in experimental settings is directed to the cooperative partner animal or rather to the experimenter distributing the rewards unequally. In the current study we aimed to further investigate whether the presence of an experimenter distributing rewards is essential in order to elicit inequity aversion in dogs. We tested 22 dog dyads in an inequity task, requiring dyads to alternately press a buzzer in order to receive rewards of equal or unequal value. We manipulated the extent of the experimenter's involvement in the task: in the experimenter-present version an experimenter gave a command to the dogs to press the buzzer and delivered the rewards by pushing the bowls into the dogs' enclosure. In contrast, in the experimenter-absent version, no experimenter was visible and the buzzer and bowls were moved from behind a curtain. We found that dogs did not respond to the unequal treatment regardless of the experimenter's involvement in the task. Nonetheless, we found that dogs based their behavior on frustration and social facilitation in the experimenter-absent version of the task, suggesting that a social interaction with an experimenter may be one aspect necessary to elicit inequity aversion. One potential explanation for the absence of inequity aversion in the experimenter-present version of the task might be the reward delivery method. Using separate sets of reward bowls for each dog instead of a shared bowl could have removed a potentially important competitive aspect (i.e., shared resource) from the inequity paradigm. In addition, delivering the rewards via bowls, rather than directly handing the rewards to the dogs, might have caused dogs to perceive the task as less cooperative. These results suggest that both the presence of an experimenter causing inequity and the inclusion of a competitive or cooperative element in the task may be basic requirements for eliciting inequity aversion.
The cognitive basis for the correlation between word order and the position of syntactic markers

The correlation between word order and preand postpositional markers (Greenberg, 1963) was examined using a VX (or VSO) type of language with prepositional markers (VX-Pre), a VX with postpositional markers (VX-Post), and a third condition (Mixed) in which word order and the position of markers were randomly placed. The response variable was the time needed to describe reference situations presented. The results showed that the description time increased from VX-Pre through VX-Post to Mixed, demonstrating that less cognitive load was imposed on subjects in VX-Pre than on subjects in VX-Post, and this in turn than on subjects in Mixed. The results were discussed in terms of the principle of natural serialization (Venneman, 1974, 1975).
Biosynthesis of Indole-3-Acetic Acid by New Klebsiella oxytoca Free and Immobilized Cells on Inorganic Matrices

While many natural and synthetic compounds exhibit auxin-like activity in bioassays, indole-3-acetic acid (IAA) is recognized as the key auxin in most plants. IAA has been implicated in almost all aspects of plant growth and development and a large array of bacteria have been reported to enhance plant growth. Cells of Klebsiella oxytoca isolated from the rhizosphere of Aspidosperma polyneuron and immobilized by adsorption on different inorganic matrices were used for IAA production. The matrices were prepared by the sol-gel method and the silica-titanium was the most suitable matrix for effective immobilization. In operational stability assays, IAA production was maintained after four cycles of production, obtaining 42.80 ± 2.03 μg mL−1 of IAA in the third cycle, which corresponds to a 54% increase in production in relation to the first cycle, whereas free cells began losing activity after the first cycle. After 90 days of storage at 4°C the immobilized cells showed the slight reduction of IAA production without significant loss of activity.
Kenyan endemic bird species at home in novel ecosystem

Abstract Riparian thickets of East Africa harbor a large number of endemic animal and plant species, but also provide important ecosystem services for the human being settling along streams. This creates a conflicting situation between nature conservation and land‐use activities. Today, most of this former pristine vegetation is highly degraded and became replaced by the invasive exotic Lantana camara shrub species. In this study, we analyze the movement behavior and habitat use of a diverse range of riparian bird species and model the habitat availability of each of these species. We selected the following four riparian bird species: Bare‐eyed Thrush Turdus tephronotus, Rufous Chatterer Turdoides rubiginosus, Zanzibar Sombre Greenbul Andropadus importunus insularis, and the Kenyan endemic Hinde′s Babbler Turdoides hindei. We collected telemetric data of 14 individuals during a 2 months radio‐tracking campaign along the Nzeeu River in southeast Kenya. We found that (1) all four species had similar home‐range sizes, all geographically restricted and nearby the river; (2) all species mainly use dense thicket, in particular the invasive L. camara; (3) human settlements were avoided by the bird individuals observed; (4) the birds' movement, indicating foraging behavior, was comparatively slow within thickets, but significantly faster over open, agricultural areas; and (5) habitat suitability models underline the relevance of L. camara as suitable surrogate habitat for all understoreyed bird species, but also show that the clearance of thickets has led to a vanishing of large and interconnected thickets and thus might have negative effects on the population viability in the long run.
Functional Specialization within the Medial Frontal Gyrus for Perceptual Go/No-Go Decisions Based on What, When, and Where Related Information: An fMRI Study

Cortical systems engaged during executive and volitional functions receive and integrate input from multiple systems. However, these integration processes are not well understood. In particular, it is not known whether these input pathways converge or remain segregated at the executive levels of cortical information processing. If unilateral information streams are conserved within structures that serve high-level executive functions, then the functional organization within these structures would predictably be similarly organized. If, however, unilateral input information streams are integrated within executive-related structures, then activity patterns will not necessarily reflect lower organizations. In this study, subjects were imaged during the performance of a perceptual go/nogo task for which instructions were based on spatial (where), temporal (when), or object (what) stimulus features known to engage unilateral processing streams, and the expected hemispheric biases were observed for early processing areas. For example, activity within the inferior and middle occipital gyri, and the middle temporal gyrus, during the what and when tasks, was biased toward the left hemisphere, and toward the right hemisphere during the where task. We discover a similar lateralization within the medial frontal gyrus, a region associated with high-level executive functions and decision-related processes. This lateralization was observed regardless of whether the response was executed or imagined, and was demonstrated in multiple sensory modalities. Although active during the go/no-go task, the cingulate gyrus did not show a similar lateralization. These findings further differentiate the organizations and functions of the medial frontal and cingulate executive regions, and suggest that the executive mechanisms operative within the medial frontal gyrus preserve fundamental aspects of input processing streams.