Miracle-dz/UniFAR-FTUs huggingface dataset:
A broadband noise-canceling CMOS LNA for 3.1-10.6-GHz UWB receiver

An ultra-wideband (UWB) noise-canceling low-noise amplifier (LNA) is presented. By using inductive series and shunt peaking techniques, the effective bandwidth of noise canceling is extended. This LNA has been fabricated in a 0.18/spl mu/m CMOS process. The measured noise figure is 4.5-5.1dB over 3.1-10.6-GHz, while the power gain is 9.7dB with a -3-dB bandwidth of 1.2-11.9-GHz. It consumes 20mW from a 1.8V supply and occupies only 0.59mm/sup 2/.
Chronotherapy With the Angiotensin-Converting Enzyme Inhibitor Ramipril in Essential Hypertension: Improved Blood Pressure Control With Bedtime Dosing

Clinical studies have demonstrated a different effect on blood pressure of some angiotensin-converting enzyme inhibitors when administered in the morning versus the evening. Their administration at bedtime resulted in a higher effect on nighttime blood pressure as compared with morning dosing. This study investigated the administration time-dependent effects of ramipril on ambulatory blood pressure. We studied 115 untreated hypertensive patients, 46.7±11.2 years of age, randomly assigned to receive ramipril (5 mg/d) as a monotherapy either on awakening or at bedtime. Blood pressure was measured for 48 hours before and after 6 weeks of treatment. The blood pressure reduction during diurnal activity was similar for both treatment times. Bedtime administration of ramipril, however, was significantly more efficient than morning administration in reducing asleep blood pressure. The awake:asleep blood pressure ratio was decreased after ramipril on awakening but significantly increased toward a more dipping pattern after bedtime dosing. The proportion of patients with controlled ambulatory blood pressure increased from 43% to 65% (P=0.019) with bedtime treatment. Nocturnal blood pressure regulation is significantly better achieved at bedtime as compared with morning administration of ramipril, without any loss in efficacy during diurnal active hours. This might be clinically important, because nighttime blood pressure has been shown to be a more relevant marker of cardiovascular risk than diurnal mean values. The change in the dose-response curve, increased proportion of controlled patients, and improved efficacy on nighttime blood pressure with administration of ramipril at bedtime should be taken into account when prescribing this angiotensin-converting enzyme inhibitor for treatment of essential hypertension.
Photorhabdus‐nematode symbiosis is dependent on hfq‐mediated regulation of secondary metabolites

Photorhabdus luminescens maintains a symbiotic relationship with the nematodes Heterorhabditis bacteriophora and together they infect and kill insect larvae. To maintain this symbiotic relationship, the bacteria must produce an array of secondary metabolites to assist in the development and replication of nematodes. The regulatory mechanisms surrounding production of these compounds are mostly unknown. The global post-transcriptional regulator, Hfq, is widespread in bacteria and performs many functions, one of which is the facilitation of sRNA binding to target mRNAs, with recent research thoroughly exploring its various pleiotropic effects. Here we generate and characterize an hfq deletion mutant and show that in the absence of hfq, the bacteria are no longer able to maintain a healthy symbiosis with nematodes due to the abolishment of the production of all known secondary metabolites. RNAseq led us to produce a second deletion of a known repressor, HexA, in the same strain, which restored both metabolite production and symbiosis.
The Psychology of Evaluation : Affective Processes in Cognition and Emotion

Contents: J. Musch, K.C. Klauer, The Psychology of Evaluation: An Introduction. Part I:Mechanisms, Boundary Conditions, and Theories of Automatic Evaluation. K.C. Klauer, J. Musch, Affective Priming: Findings and Theories. D. Wentura, K. Rothermund, The "Meddling-In" of Affective Information: A General Model of Automatic Evaluation. J. Glaser, Reverse Priming: Implications for the (Un)conditionality of Automatic Evaluation. K. Fiedler, The Hidden Vicissitudes of the Priming Paradigm in Evaluative Judgment Research. Part II:Evaluative Judgments and the Acquisition of Evaluations. D. Hermans, F. Baeyens, P. Eelen, On the Acquisition and Activation of Evaluative Information in Memory: The Study of Evaluative Learning and Affective Priming Combined. M. Ferguson, J. Bargh, The Constructive Nature of Automatic Evaluation. P. Winkielman, N. Schwarz, T. Fazendeiro, R. Reber, The Hedonic Marking of Processing Fluency: Implications for Evaluative Judgment. Part III:Individual Differences and Indirect Measures of Evaluation. J. De Houwer, A Structural Analysis of Indirect Measures of Attitudes. R. Banse, Beyond Verbal Self-Report: Priming Methods in Relationship Research. M.D. Robinson, P.T. Vargas, E.C. Crawford, Putting Process Into Personality, Appraisal, and Emotion: Evaluative Processing as a Missing Link. Part IV:The Role of Evaluation in Mood, Emotion, and Behavior. P. Niedenthal, A. Rohmann, N. Dalle, What Is Primed by Emotion Concepts and Emotion Words? G. Clore, S. Colcombe, The Parallel Worlds of Affective Concepts and Feelings. R. Neumann, J. Forster, F. Strack, Motor Compatibility: The Bidirectional Link Between Behavior and Evaluation.
A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children.

Magnesium, a vasodilator, anti-inflammatory, and pain reliever, could alter the pathophysiology of sickle cell pain crises. We hypothesized that intravenous magnesium would shorten length of stay, decrease opioid use, and improve health-related quality of life (HRQL) for pediatric patients hospitalized with sickle cell pain crises. The Magnesium for Children in Crisis (MAGiC) study was a randomized, double-blind, placebo-controlled trial of intravenous magnesium vs normal saline placebo conducted at 8 sites within the Pediatric Emergency Care Applied Research Network (PECARN). Children 4 to 21 years old with hemoglobin SS or Sβ(0) thalassemia requiring hospitalization for pain were eligible. Children received 40 mg/kg of magnesium or placebo every 8 hours for up to 6 doses plus standard therapy. The primary outcome was length of stay in hours from the time of first study drug infusion, compared using a Van Elteren test. Secondary outcomes included opioid use and HRQL. Of 208 children enrolled, 204 received the study drug (101 magnesium, 103 placebo). Between-group demographics and prerandomization treatment were similar. The median interquartile range (IQR) length of stay was 56.0 (27.0-109.0) hours for magnesium vs 47.0 (24.0-99.0) hours for placebo (P = .24). Magnesium patients received 1.46 mg/kg morphine equivalents vs 1.28 mg/kg for placebo (P = .12). Changes in HRQL before discharge and 1 week after discharge were similar (P > .05 for all comparisons). The addition of intravenous magnesium did not shorten length of stay, reduce opioid use, or improve quality of life in children hospitalized for sickle cell pain crisis. This trial was registered at www.clinicaltrials. gov as #NCT01197417.
Robust background exclusion for salient object detection

Recently, investigating boundary prior to aid other low-level image cues, have gained great attention in salient object detection. Although the salient regions are mostly located in the image center, the inverse might not necessarily be true. In addition, such kind of center-bias assumption is very simple and fragile, especially when salient regions often touch the image boundary or the images are with complex background (e.g., small scale and high contrast patterns). To this end, this paper presents a new framework to address these two issues. First, we propose a robust background descriptor, called boundary connectivity, which is calculated to measure how heavily a region is connected to image boundary. This measure has an intuitive geometrical interpretation that are absent in previous saliency formulation. In order to reduce the effect of imprecise object boundary, we also propose a multiple layer over-segmentation framework to integrate multiple low-level cues, including our background measure, to highlight clean and uniform saliency maps. The experiment results demonstrate that our method achieves state-of-the-art results on MSRA-1000 datasets.
In Situ Exploration of Large Dynamic Networks

The analysis of large dynamic networks poses a challenge in many fields, ranging from large bot-nets to social networks. As dynamic networks exhibit different characteristics, e.g., being of sparse or dense structure, or having a continuous or discrete time line, a variety of visualization techniques have been specifically designed to handle these different aspects of network structure and time. This wide range of existing techniques is well justified, as rarely a single visualization is suitable to cover the entire visual analysis. Instead, visual representations are often switched in the course of the exploration of dynamic graphs as the focus of analysis shifts between the temporal and the structural aspects of the data. To support such a switching in a seamless and intuitive manner, we introduce the concept of in situ visualization- a novel strategy that tightly integrates existing visualization techniques for dynamic networks. It does so by allowing the user to interactively select in a base visualization a region for which a different visualization technique is then applied and embedded in the selection made. This permits to change the way a locally selected group of data items, such as nodes or time points, are shown - right in the place where they are positioned, thus supporting the user's overall mental map. Using this approach, a user can switch seamlessly between different visual representations to adapt a region of a base visualization to the specifics of the data within it or to the current analysis focus. This paper presents and discusses the in situ visualization strategy and its implications for dynamic graph visualization. Furthermore, it illustrates its usefulness by employing it for the visual exploration of dynamic networks from two different fields: model versioning and wireless mesh networks.
Posterior to Anteriorly Directed Screws for Management of Talar Neck Fractures

Background: Screws placed from posterior to anterior have been shown to be biomechanically and anatomically superior in the fixation of talar neck and neck-body fractures, yet most surgeons continue to place screws from an anterior start point. The safety and efficacy of percutaneously applied posterior screws has not been clinically defined, and functional outcomes after their use is lacking. Methods: After institutional review board approval, we performed a retrospective review of 24 consecutive talar neck fractures treated by a single surgeon that utilized posterior-to-anterior screw fixation. Clinical, radiographic, and functional outcomes were assessed at a minimum follow-up of 12 months. Functional outcomes including the American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score, Olerud-Molander Scores, and the Short Form 36 (SF-36) measurement were collected and reviewed. Average patient follow-up was 44 months. Results: According to the classification system of Canale and Kelly, there were 4 type I fractures, 15 type II fractures, 4 type III fractures, and 1 type IV fracture. Four patients had open fractures. One superficial wound infection occurred, 1 patient reported FHL stiffness, and 6 complained of numbness or paresthesias in the distribution of the sural nerve (5 transient, 1 permanent). One reoperation was required to exchange a screw impinging on the talonavicular joint. Radiographically, 44% developed a positive Hawkins sign, and the specificity of this finding was 100% for talar dome viability. Avascular necrosis developed in 43% of patients, with 33% revascularizing and none going on to collapse. Subtalar arthrosis developed in 62% of patients. Conclusion: Screws placed from posterior to anterior are a useful technique in the treatment of talar neck fractures. Functional outcomes following their use appear favorable compared with recent reports with minimal risk to local structures. Level of Evidence: Level IV, retrospective case series.
ICP27 Interacts with the RNA Export Factor Aly/REF To Direct Herpes Simplex Virus Type 1 Intronless mRNAs to the TAP Export Pathway

ABSTRACT Herpes simplex virus type 1 (HSV-1) protein ICP27 facilitates the export of viral intronless mRNAs. ICP27 shuttles between the nucleus and cytoplasm, which has been shown to require a leucine-rich nuclear export sequence (NES). ICP27 export was reported to be sensitive to the CRM1 inhibitor leptomycin B (LMB) in HSV-1-infected cells but not in Xenopus oocytes, where ICP27 interacts with the export factor Aly/REF to access the TAP export pathway. Here, we show that ICP27 interacts with Aly/REF in HSV-1-infected mammalian cells and that Aly/REF stimulates export of viral intronless RNAs but does not cross-link to these RNAs. During infection, Aly/REF was no longer associated with splicing factor SC35 but moved into structures that colocalized with ICP27, suggesting that ICP27 recruits Aly/REF from spliceosomes to viral intronless RNAs. Further, ICP27 was found to interact in vivo with TAP but not with CRM1. In vitro export assays showed that ICP27 export was not sensitive to LMB but was blocked by a dominant-negative TAP deletion mutant lacking the nucleoporin interaction domain. These data suggest that ICP27 uses the TAP pathway to export viral RNAs. Interestingly, the leucine-rich N-terminal sequence was required for efficient export, even though ICP27 export was LMB insensitive. Thus, this region is required for efficient ICP27 export but does not function as a CRM1-dependent NES.
Underload instabilities in packet networks with flow schedulers

Instability in packet-switching networks is normally associated with overload conditions, since queueing network models show that, in simple configurations, only overload generates instability. However, some results showing that instability can happen also in underloaded queueing networks began to appear about a decade ago. Underload instabilities can be produced by: 1) customer routes that visit the same queues several times; 2) variations of the customer service times at the different queues; and 3) complex scheduling algorithms. We study, using fluid models and adversarial queueing theory, possible underload instabilities due to flow schedulers in packet networks, focusing on output queued switches with strict priority (SP) schedulers and Generalized Processor Sharing (GPS) schedulers. The considered scenarios always refer to acyclic packet routes and consider customer service times that vary only according to channel capacities, thus resembling the approaches being currently considered to provide QoS in the Internet. Our (in)stability results are rather surprising: SP schedulers appear to be more robust than GPS schedulers whenever exact information on the effective average packet flow rates is not available.
Assessment of sexual interest in child sex offenders by the use of a computerized measure.

This thesis investigates Rapid Serial Visual Presentation (RSVP) procedure as a tool to evaluate sexual interest in child sex offenders. Chapters 1 and 2 evaluate sexual interest in child sex offenders, exploring the attentional blink theories. Chapter 3 examines RSVP in child sex offenders and offenders with no sexual offence history, showing child sex offenders displaying enhanced attentional blink towards images of children. Chapter 4 examined released child sex offenders who did not show the hypothesised attentional blink effect. Chapter 5 looked into RSVP responses of fathers with children under two, and shows an opposite pattern of response to child sex offenders. Chapter 6 showed that RSVP, using male and female images, elicited heightened attentional blink in a normative sample of females, but not the male sample. Chapter 7 examined the RSVP using erotic images of males and females on heterosexual males and females with no significant effect. Chapter 8 tested the reliability and validity of the RSVP in a subsample using the procedure on two separate occasions, showing significant improvement from Session 1 to Session 2. This shows practice effect can influence performance on the RSVP. The main discussion evaluates the results in terms of implications for the utility of the RSVP.
Phosphatase and oxygen radical-generating activities of mammalian purple acid phosphatase are functionally independent.

Bone-resorbing osteoclasts and activated macrophages express large amounts of tartrate-resistant acid phosphatase (TRAP), an iron-containing enzyme with unknown biological function. We studied acid phosphatase (AcP) and reactive oxygen species (ROS)-generating activities of recombinant rat TRAP. pH optimum was 4.5 for AcP activity and 6.5 for ROS-generating activity. Replacement of His113 and His216 by site-directed mutagenesis severely inhibited AcP activity, but had no significant effects on ROS-generating activity. Substrate specificity was not affected by the mutations. These results suggest that AcP and ROS-generating activities of TRAP are functionally independent.
Lack of FLT3-TKD835 gene mutation in toxicity of sulfur mustard in Iranian veterans

Objective(s): Sulfur mustard (SM) was used by the Iraqi army against the Iranian troops in the Iran-Iraq war from 1983–1988. This chemical gas affects different organs including the skin, lungs and the hematopoietic system. Any exposure to SM increases the risk of chromosomal breaking, hyperdiploidy and hypodiploidy. Studies have shown that the risk for acute myeloblastic and lymphoblastic leukemia increases in veterans exposed to SM. FLT3 mutations including ITD and TKD mutations had been observed in some cases of leukemia. Therefore, we aimed to investigate the frequency of FLT3-TKD835 mutations in the veterans exposed to SM agent. Materials and Methods: We studied 42 patients who were exposed to SM during the war in Khorasan Razavi province, Mashhad, Iran in 2012. As control group, 30 healthy males were selected from first-degree relatives of the patients. For assessment of TKD835 mutation, DNA was extracted and RFLP-PCR was performed. Results: Analysis of RFLP-PCR data showed no FLT-3 TKD mutation in any of the patients. Conclusion: Although contact with SM can increase the risk of malignancy especially hematologic neoplasms, results of the study show that another mechanism of leukemogenesis, other than FLT3-TKD mutation, may be the reason for increased risk of leukemia in SM toxicity.
Oral Language and Literacy Learning in Context: The Role of Social Relationships. Reading Research Report No. 57.

The effects of friend/nonfriend groupings on early literacy were examined. Literacy was defined in terms of children's use of literate language and traditional school based literacy. We predicted that friend, compared to nonfriend, conditions elicit more conflicts/resolutions, emotional terms, and literate language; that the friend ship condition is particularly supportive for girls' exhibition of literate language and emotion terms; and that literate language predicts school-based literacy. Same gen der dyads of kindergarten friends and nonfriends were observed in experimental literacy events and measures of oral language and reading and writing were col lected. Results generally supported the predictions. Results are discussed in terms of the importance of close relationships and emotion for early literacy development.
Quantum-Assisted Indoor Localization for Uplink mm-Wave and Downlink Visible Light Communication Systems

With the proliferation of millimeter-Wave (mm-Wave) systems and visible light communications (VLCs), indoor localization may find multiple applications. When high localization accuracy is required and triangulation is not possible due to the infrastracture and scenario limitations, the computational complexity of searching on a virtual grid may become excessive. In this paper, we amalgamate uplink mm-Wave-based and downlink VLC-based localization. We employ quantum search algorithms for reducing the computational complexity required for achieving the optimal full-search-based performance. Regarding the uplink mm-Wave-based localization, we employ a single anchor equipped with multiple antenna elements and we exploit the specular multipath components created by the room’s walls. The proposed solutions outperform the state-of-the-art algorithms. Furthermore, various channel models are considered based on real indoors mm-Wave measurements. By using the VLC-based triangulation for downlink and the proposed mm-Wave-based localization algorithm for uplink, there was an average positioning error of 5.6 cm in the room considered, while requiring 261 database queries on average.
Effect of different parameters used for in vitro gene electrotransfer on gene expression efficiency, cell viability and visualization of plasmid DNA at the membrane level

Gene electrotransfer is a nonviral method used for DNA delivery into cells. Several steps are involved. One of them is the interaction of DNA with the cell membrane, which is crucial before DNA can enter the cell. We analysed the level of DNA–membrane interaction in relation to electrotransfer efficiency and the importance of the electrophoretic accumulation of DNA at the cell membrane. Systematic comparison of long‐duration, short‐duration and combinations of electropermeabilizing short (high‐voltage; HV) and electrophoretic long (low‐voltage; LV) pulses were performed. The effect of Mg2+ ion concentrations on electrotransfer and their effect on DNase activity were explored.
On the Origin of Utility, Weighting, and Discounting Functions: How They Get Their Shapes and How to Change Their Shapes

We present a theoretical account of the origin of the shapes of utility, probability weighting, and temporal discounting functions. In an experimental test of the theory, we systematically change the shape of revealed utility, weighting, and discounting functions by manipulating the distribution of monies, probabilities, and delays in the choices used to elicit them. The data demonstrate that there is no stable mapping between attribute values and their subjective equivalents. Expected and discounted utility theories, and also their descendants such as prospect theory and hyperbolic discounting theory, simply assert stable mappings to describe choice data and offer no account of the instability we find. We explain where the shape of the mapping comes from and, in describing the mechanism by which people choose, explain why the shape depends on the distribution of gains, losses, risks, and delays in the environment. Data, as supplemental material, are available at http://dx.doi. org/10.1287/mnsc.2013. 1853 . This paper was accepted by Yuval Rottenstreich, judgment and decision making.