Miracle-dz/UniFAR-FTUs huggingface dataset:
Spatio-Temporal Variation in Effects of Upwelling on the Fatty Acid Composition of Benthic Filter Feeders in the Southern Benguela Ecosystem: Not All Upwelling Is Equal

Variability in mesoscale nearshore oceanographic conditions plays an important role in the distribution of primary production and food availability for intertidal consumers. Advection of nutrient rich waters by upwelling usually allows the proliferation of diatoms, later replaced by dinoflagellates. We examined upwelling effects on the fatty acid (FA) signature of a benthic intertidal filter feeder to identify its response to pulsed variability in food availability. The study took place in two contrasting seasons and at two upwelling and two non-upwelling sites interspersed within the southern Benguela upwelling system of South Africa. We investigated the FA composition of the adductor muscles and gonads of the mussel Mytilus galloprovincialis to assess how FA are apportioned to the different tissues and whether this changes between upwelling and non-upwelling conditions. In situ temperature loggers used to identify upwelling conditions at the four sites indicated that such events occurred only at the upwelling centres and only in summer. Tissues differed strongly, with gonads presenting a higher proportion of essential FAs. This could reflect the faster turnover rate of gonad tissue or preferential retention of specific FA for reproductive purposes. FA composition did not vary as a direct function of upwelling, but there were strong dissimilarities among sites. Upwelling influenced mussel diets at one upwelling site while at the other, the expected signature of upwelling was displaced downstream of the core of upwelling. Condition Index (CI) and Gonad Index (GI) differed among sites and were not influenced by upwelling, with GI being comparable among sites. In addition, FA proportions were consistent among sites, indicating similar food quality and quantity over time and under upwelling and non-upwelling conditions. This suggests that the influence of upwelling on the west coast of South Africa is pervasive and diffuse, rather than discrete; while nearshore retention or advection of upwelled water is critical and site-specific so that the effects of upwelling differ even among sites categorised as upwelling centres.
Culture medium of bone marrow-derived human mesenchymal stem cells effects lymphatic endothelial cells and tumor lymph vessel formation

Human bone marrow mesenchymal stem cells (hBM-MSCs) favor tumor growth and metastasis in vivo and in vitro. Neovascularization is involved in several pathological conditions, including tumor growth and metastasis. Previous studies have demonstrated that human bone marrow MSC-derived conditioned medium (hBM-MSC-CM) can promote tumor growth by inducing the expression of vascular epidermal growth factor (VEGF) in tumor cells. However, the effect of BM-MSCs on tumor lymph vessel formation has yet to be elucidated. In the present study, the effect of BM-MSCs on processes involved in lymph vessel formation, including tube formation, migration and proliferation, was investigated in human-derived lymphatic endothelial cells (HDLECs). It was identified that hBM-MSC-CM promoted the tube formation and migration of HDLECs. In addition, tumor cells were revealed to participate in lymph vessel formation. In the present study, the SGC-7901, HGC-27 and GFP-MCF-7 cell lines were treated with hBM-MSC-CM. The results demonstrated that the expression of the lymph-associated markers, prospero homeobox protein 1 and VEGF receptor-3, were increased in the SGC-7901 and HGC-27 cell lines, but not in the GFP-MCF-7 cells. The tube formation assay demonstrated that the HGC-27 cells treated with hBM-MSC-CM for 20 days underwent tube formation. These findings indicate that hBM-MSC-CM can promote tube formation in HDLECs and HGC-27 cells, which may be associated with lymph vessel formation during tumor growth and metastasis.
FACTORS AFFECTING BUNKER SILO DENSITIES

High densities in bunker silos minimize losses and reduce storage costs; however, the guidelines to attain high densities are based on relatively little research. The objective of this study was to determine those practices or factors most correlated with bunker silo density. Density was measured in 175 bunker silos across Wisconsin using core samples collected at chest height (1.13 m, 3.70 ft, on average) across the feed-out face. Silo filling practices were surveyed and correlated with density. Most silages sampled were alfalfa or corn. Dry matter densities ranged from 106 to 434 kg/m 3 (6.6 to 27.1 lb/ft 3 ). The core densities were correlated with the height of silage above the core, indicating the effect of self-compaction. To adjust for this, all densities were corrected for the median depth below the surface (2.16 m or 7.09 ft) using the equations of Pitt (1983) for density with height for the center of tower silos. The adjusted dry matter densities were most strongly correlated with how thinly a load was spread (L), tractor weight (W), packing time per tonne as-fed (T), and dry matter content (D). These four factors were combined into a packing factor [W (TD)1/2 L –1 ] that explained 18.2% of the variation in dry matter density. Additional factors such as the use of dual wheels, etc. did not significantly improve the prediction of dry matter density. An equation was developed to predict average density in a bunker silo based on the packing factor plus crop height in the silo.
To Continue or not to Continue? Drivers of Recurrent Partnering in Temporary Organizations

While research has provided ample evidence that temporal (dis-)continuity in partnering is highly consequential for the governance and performance outcomes of temporary organizations, we know much less about the conditions that drive the members of temporary organizations to engage in recurrent partnering. Focusing on project organizations, the present research offers theoretical arguments and related empirical evidence that illuminate when and why project-leading organizations expect to continue collaboration with the same project partner in future projects. Specifically, we show that expectations of recurrent collaboration are a function of backward-looking experiential learning and forward-looking opportunity cost assessments. Our findings contribute to better understanding of temporality in temporary organizations by uncovering a set of factors conducive to explaining when and why the same partners engage in temporary sequences of projects.
Bee venom inhibits growth of human cervical tumors in mice

We studied whether bee venom (BV) inhibits cervical tumor growth through enhancement of death receptor (DR) expressions and inactivation of nuclear factor kappa B (NF-κB) in mice. In vivo study showed that BV (1 mg/kg) inhibited tumor growth. Similar inhibitory effects of BV on cancer growth in primary human cervical cancer cells were also found. BV (1–5 μg/ml) also inhibited the growth of cancer cells, Ca Ski and C33Aby the induction of apoptotic cell death in a dose dependent manner. Agreed with cancer cell growth inhibition, expression of death receptors; FAS, DR3 and DR6, and DR downstream pro-apoptotic proteins including caspase-3 and Bax was concomitantly increased, but the NF-κB activity and the expression of Bcl-2 were inhibited by treatment with BV in tumor mice, human cancer cell and human tumor samples as well as cultured cancer cells. In addition, deletion of FAS, DR3 and DR6 by small interfering RNA significantly reversed BV-induced cell growth inhibitory effects as well as NF-κB inactivation. These results suggest that BV inhibits cervical tumor growth through enhancement of FAS, DR3 and DR6 expression via inhibition of NF-κB pathway.
Treatment of Tinnitus With a Customized, Dynamic Acoustic Neural Stimulus: Underlying Principles and Clinical Efficacy

Tinnitus has been challenging to treat with consistently positive results. The Neuromonics Tinnitus Treatment is a newly available approach to the treatment of clinically significant, problematic tinnitus (and reduced sound tolerance) that was developed with the intention of simultaneously addressing the auditory, attentional, and emotional processes underlying the condition. It uses a prescribed acoustic stimulus, customized for each patient's individual audiometric profile, which provides a broad frequency stimulus to address the effects of auditory deprivation, promotes relief and relaxation with the intention of reducing engagement of the limbic system/amygdala and autonomic nervous system, and applies the principles of systematic desensitization to address the attentional processes. This article describes the underlying principles behind this approach. It also summarizes evidence for clinical efficacy from controlled clinical studies and from a private practice clinical setting, where it has been shown to provide consistently positive outcomes for patients meeting suitability criteria.
A Reverse Dipping Pattern Predicts Cardiovascular Mortality In a Clinical Cohort

An abnormal dipping pattern in ambulatory blood pressure monitoring (ABPM) is a cardiovascular (CV) risk factor. However, its impact on CV mortality has not been investigated sufficiently in clinical practice to be considered a standard parameter. We assessed the association between abnormal dipping patterns and increased CV mortality in a tertiary hospital in Korea. Our retrospective cohort study included 401 patients who underwent ABPM between 1994 and 1996 in Hanyang University Hospital, Seoul, Korea. The patients were classified as risers (<0% drop in systolic BP; n=107), and others included dippers and non-dippers (≥0% drop, n=294). The follow-up period was 120 months. The frequency of CV mortality was 14.0% in risers and 5.8% in others. A Cox regression analysis found a significant association between dipping pattern and CV mortality, after adjusting for age, gender, body mass index, hypertension, diabetes mellitus, smoking and hypercholesterolemia. Risers were at greater risk of CV death than others (RR, 3.02, P=0.022), but there was no difference in event rates between dippers and non-dippers. The reverse dipping pattern may be more frequent in clinical settings than in the population at large, and it is strongly associated with increased risk of CV mortality in Korea.
Probing the structure of protoplanetary disks: a comparative study of DM Tau, LkCa 15, and MWC 480

Context. The physical structure of proto-planetary disks is not yet well constrained by current observations. Millimeter interferometry is an essential tool to investigate young disks. Aims. We study the vertical and radial temperature distribution in a few well-known disks from an observational perspective. The surface density distribution of CO and HCO + and the scale-height are also investigated. Methods. We report CO observations at sub-arcsecond resolution with the IRAM array of the disks surrounding MWC 480, LkCa 15, and DM Tau, and simultaneous measurements of HCO + J = 1 → 0. To derive the disk properties, we fit a standard disk model in which all parameters are power laws of the distance to the star to the data. Possible biases associated with the method are detailed and explained. We compare the properties of the observed disks with similar objects. Results. We find evidence for a vertical temperature gradient in the disks of MWC 480 and DM Tau, as in AB Aur, but not in LkCa 15. The disk temperatures increase with stellar effective temperature. Except for AB Aur, the bulk of the CO gas is at temperatures smaller than 17 K, below the condensation temperature on grains. We find the scale height of the CO distribution to be larger (by 50%) than the expected hydrostatic scale height. The total amount of CO and the isotopologue ratio depends globally on the star. The more UV luminous objects appear to have more CO, but there is no simple dependency. The [ 13 CO]/[HCO + ] ratio is ∼600, with substantial variations between sources, and with radius. The temperature behavior is consistent with expectations, but published chemical models have difficulty reproducing the observed CO quantities. Changes in the slope of the surface density distribution of CO, compared to the continuum emission, suggest a more complex surface density distribution than is usually assumed in models. Vertical mixing seems an important chemical agent, as does photo-dissociation by the ambient UV radiation at the disk’s outer edge.
Robust Training under Linguistic Adversity

Deep neural networks have achieved remarkable results across many language processing tasks, however they have been shown to be susceptible to overfitting and highly sensitive to noise, including adversarial attacks. In this work, we propose a linguistically-motivated approach for training robust models based on exposing the model to corrupted text examples at training time. We consider several flavours of linguistically plausible corruption, include lexical semantic and syntactic methods. Empirically, we evaluate our method with a convolutional neural model across a range of sentiment analysis datasets. Compared with a baseline and the dropout method, our method achieves better overall performance.
The effect of chalk on the finger–hold friction coefficient in rock climbing

The main purpose of this study was to examine the effect of chalk on the friction coefficient between climber's fingers and two different rock types (sandstone and limestone). The secondary purpose was to investigate the effects of humidity and temperature on the friction coefficient and on the influence of chalk. Eleven experienced climbers took part in this study and 42 test sessions were performed. Participants hung from holds which were fixed on a specially designed hang board. The inclination of the hang board was progressively increased until the climber's hand slipped from the holds. The angle of the hang board was simultaneously recorded by using a gyroscopic sensor and the friction coefficient was calculated at the moment of slip. The results showed that there was a significant positive effect of chalk on the coefficient of friction (+18.7% on limestone and +21.6% on sandstone). Moreover sandstone had a higher coefficient of friction than limestone (+15.6% without chalk, +18.4% with chalk). These results confirmed climbers' belief that chalk enhances friction. However, no correlation with humidity/temperature and friction coefficient was noted which suggested that additional parameters should be considered in order to understand the effects of climate on finger friction in rock climbing.
A fearful engine of power: conceptualizing the communication–security relationship

ABSTRACT This essay isolates and explores a growing body of communication research concerned with ‘security. ’ It opens by defining this concept, and discussing recent geopolitical and interdisciplinary trends contributing to its association with communication. It subsequently reviews distinctive engagement with ‘security’ displayed in five disciplinary subfields, including strategic communication, discourse analysis, public argument studies, rhetoric, and critical-cultural communication studies. It concludes by providing four sets of recommendations for future development of this research program.
microRNA Expression during Trophectoderm Specification

Background Segregation of the trophectoderm from the inner cell mass of the embryo represents the first cell-fate decision of mammalian development. Transcription factors essential for specifying trophectoderm have been identified, but the role of microRNAs (miRNAs) in modulating this fate-choice has been largely unexplored. We have compared miRNA expression in embryonic stem cell (ESC)-derived trophectoderm and in staged murine embryos to identify a set of candidate miRNAs likely to be involved in trophectoderm specification. Results We profiled embryonic stem cells (ESCs) as they were induced to differentiate into trophectodermal cells by ectopic expression of HRas/Q61L. We also profiled murine embryos at progressive stages of preimplantation development (zygote, 2-cell, 4-cell, 8-cell, morula, and blastocyst), which includes the time window in which the trophectoderm is specified in vivo. Q61L/H Conclusions We describe miRNA expression changes that occur during trophectoderm specification and validate that our in vitro system faithfully recapitulates trophectoderm specification in vivo. By comparing our in vitro and in vivo datasets, we have identified a minimal set of candidate miRNAs likely to play a role in trophectoderm specification. These miRNAs are predicted to regulate a host of development-associated target genes, and many of these miRNAs have previously reported roles in development and differentiation. Additionally, we highlight a number of miRNAs whose tight developmental regulation may reflect a functional role in other stages of embryogenesis. Our embryo profiling data may be useful to investigators studying trophectoderm specification and other stages of preimplantation development.
Competitive Strategies of Product with Vertical Differentiation

It is an important problem for firms to choose appropriate product quality and market strategies to obtain competitive advantage on condition that many products in modern industry show clear network externality. Product differentiation is important means for corporationpsilas product to form market power and obtain non-price competitive advantage, and it is also is the main component part of market structure and organization in industrial organizational theory. Under incomplete covering market, competitive strategies on price or quantity of product with vertical differentiation and network externality are researched in the paper. The research results show: in Bertrand price competition or Cournot quantity competition, price of both products decrease with network externality increasing, and high quality product obtains higher market price, share and profit than that of low quality product. Comparative results of game equilibrium show that market profit of products based Cournot quantity competition are greater than that of based on Bertrand price competition.
Self-Legitimacy, Organisational Commitment and Commitment to Fair Treatment of Prisoners: An Empirical Study of Prison Officers in Slovenia

Recent work on legitimacy within criminal justice systems have drawn attention to self-legitimacy; that is, criminal justice professionals’ own recognition of their entitlement to power. The evidence on this aspect of legitimacy remains sparse and mainly from police studies. We know almost nothing about the self-legitimacy of prison officers. This paper contributes to filling this gap, with an empirical focus on prison officers in Slovenia. Specifically, it explores the correlates of officer self-legitimacy and the implications of self-legitimacy for commitments to the rights of prisoners and to the organisation. Results from multiple regression analyses show that quality of interpersonal relationships among officers, perceived audience legitimacy (that is, officers’ sense of their moral standing among prisoners), and distributive justice predicted self-legitimacy. Self-legitimacy was associated with increased commitment to fair treatment of prisoners but it was irrelevant to organisational commitment. The implications of these findings are discussed.
Transcriptional Regulation of Cell Cycle Genes in Response to Abiotic Stresses Correlates with Dynamic Changes in Histone Modifications in Maize

The histone modification level has been shown to be related with gene activation and repression in stress-responsive process, but there is little information on the relationship between histone modification and cell cycle gene expression responsive to environmental cues. In this study, the function of histone modifications in mediating the transcriptional regulation of cell cycle genes under various types of stress was investigated in maize (Zea mays L.). Abiotic stresses all inhibit the growth of maize seedlings, and induce total acetylation level increase compared with the control group in maize roots. The positive and negative regulation of the expression of some cell cycle genes leads to perturbation of cell cycle progression in response to abiotic stresses. Chromatin immunoprecipitation analysis reveals that dynamic histone acetylation change in the promoter region of cell cycle genes is involved in the control of gene expression in response to external stress and different cell cycle genes have their own characteristic patterns for histone acetylation. The data also showed that the combinations of hyperacetylation and hypoacetylation states of specific lysine sites on the H3 and H4 tails on the promoter regions of cell cycle genes regulate specific cell cycle gene expression under abiotic stress conditions, thus resulting in prolonged cell cycle duration and an inhibitory effect on growth and development in maize seedlings.
The Role of Sleep Spindles and Slow-Wave Activity in Integrating New Information in Semantic Memory

Assimilating new information into existing knowledge is a fundamental part of consolidating new memories and allowing them to guide behavior optimally and is vital for conceptual knowledge (semantic memory), which is accrued over many years. Sleep is important for memory consolidation, but its impact upon assimilation of new information into existing semantic knowledge has received minimal examination. Here, we examined the integration process by training human participants on novel words with meanings that fell into densely or sparsely populated areas of semantic memory in two separate sessions. Overnight sleep was polysomnographically monitored after each training session and recall was tested immediately after training, after a night of sleep, and 1 week later. Results showed that participants learned equal numbers of both word types, thus equating amount and difficulty of learning across the conditions. Measures of word recognition speed showed a disadvantage for novel words in dense semantic neighborhoods, presumably due to interference from many semantically related concepts, suggesting that the novel words had been successfully integrated into semantic memory. Most critically, semantic neighborhood density influenced sleep architecture, with participants exhibiting more sleep spindles and slow-wave activity after learning the sparse compared with the dense neighborhood words. These findings provide the first evidence that spindles and slow-wave activity mediate integration of new information into existing semantic networks.
Can forward rates be used to improve interest rate forecasts?

This paper evaluates the extent to which the explanatory power detected in the term structure in different markets and countries can actually be used to produce sensible forecasts of future short-term interest rates. Specifically, in spite of the forecasting connotation of the unbiasedness property of forward rates, actual evaluation of their forecasting performance has received scant attention in the literature on the term structure. This study uses monthly data for 1978–1998 on interest rates on Eurodeposits on the US dollar, yen, Deutsche mark, British pound, Spanish peseta, French franc, Italian lira and Swiss franc, comparing forecasts obtained from forward rates to those obtained from univariate autoregressions. By themselves, forward rates produce better one-step ahead forecasts, as well as better once-and-for all forecasts of 1-month interest rates over a full year horizon than those obtained from the own past of interest rates. The gain in one-step ahead forecasting disappears for longer maturities, although forward rates still produce better once-and-for all predictions of 3- and 6-month interest rates than univariate autoregressions for a number of currencies.