Miracle-dz/UniFAR-FTUs huggingface dataset:
‘We Are Not Here to Claim Better Services Than Any Other’: Social Exclusion among Men from Refugee Backgrounds in Urban and Regional Australia

This article reports on a mixed-methods study of social exclusion experiences among 233 resettled refugees living in urban and regional Queensland, Australia. The findings reported here are drawn from the SettleMEN project, a longitudinal investigation of health and settlement experiences among recently arrived adult men from refugee backgrounds conducted between 2008 and 2010. Using questionnaire surveys and semi-structured interviews, we examine four key dimensions of social exclusion: production, consumption, social relations, and services. We show that, overall, participants experienced high levels of social exclusion across all four dimensions. Participants living in regional areas were significantly more likely to be excluded from production, social relations, and services. We argue that there is a pressing need to tackle barriers to economic participation and discrimination in order to promote the social inclusion of men from refugee backgrounds.
The survival of indirect composite resin onlays for the restoration of root filled teeth: a retrospective medium-term study.

AIM To investigate the outcomes of root filled posterior teeth restored with indirect composite resin onlays using tooth and restoration survival as well as the quality of restoration as outcome measures. METHODOLOGY All patients were treated by the same clinician with indirect composite onlays for the restoration of root filled posterior teeth between January 2008 and February 2010 in a single clinic setting. Primary root canal treatment was performed and onlays fabricated with the indirect method using indirect composite resin. Patients were seen every 4-6 months for maintenance visits according to standard clinic protocols and each patient's individualized maintenance schedule. Tooth and restoration survival were calculated, and the onlays were evaluated in accordance with the modified US Public Health Service (USPHS) criteria. RESULTS Thirty-one premolars and one hundred and fifty-eight molars (n = 189) of 153 patients were included. The observation period ranged from 24 to 52 months with a median follow-up time of 37 months. Tooth survival was found to be 100%, whilst the restoration survival was 96.8% and the functional restoration survival 98.9% at the end of the follow-up period. According to modified USPHS criteria, the A rating had a range of 83.1-100% for all evaluation criteria. CONCLUSIONS Onlay restorations fabricated with indirect resin can be a viable option for the restoration of root filled teeth.
Individualized Systems of Instruction in Secondary Schools

This meta-analytic synthesis of findings from 51 studies indicated that use of an individualized teaching system has only a small effect on student achievement in secondary school courses. This result was consistent across a variety of academic settings and research designs and held true for both published and unpublished studies. In addition, individualized teaching systems did not contribute significantly to student self-esteem, critical thinking ability, or attitudes toward the subject matter being taught. Findings from studies of individualized college teaching are strikingly different from these secondary school findings.
Effects of Exogenous Galanin on Neuropathic Pain State and Change of Galanin and Its Receptors in DRG and SDH after Sciatic Nerve-Pinch Injury in Rat

A large number of neuroanatomical, neurophysiologic, and neurochemical mechanisms are thought to contribute to the development and maintenance of neuropathic pain. However, mechanisms responsible for neuropathic pain have not been completely delineated. It has been demonstrated that neuropeptide galanin (Gal) is upregulated after injury in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) where it plays a predominantly antinociceptive role. In the present study, sciatic nerve-pinch injury rat model was used to determine the effects of exogenous Gal on the expression of the Gal and its receptors (GalR1, GalR2) in DRG and SDH, the alterations of pain behavior, nerve conduction velocity (NCV) and morphology of sciatic nerve. The results showed that exogenous Gal had antinociceptive effects in this nerve-pinch injury induced neuropathic pain animal model. It is very interesting that Gal, GalR1 and GalR2 change their expression greatly in DRG and SDH after nerve injury and intrathecal injection of exougenous Gal. Morphological investigation displays a serious damage after nerve-pinch injury and an amendatory regeneration after exogenous Gal treatment. These findings imply that Gal, via activation of GalR1 and/or GalR2, may have neuroprotective effects in reducing neuropathic pain behaviors and improving nerve regeneration after nerve injury.
The Climate Change Attitude Survey: Measuring Middle School Student Beliefs and Intentions to Enact Positive Environmental Change

The Climate Change Attitude Survey is composed of 15 Likert-type attitudinal items selected to measure students' beliefs and intentions toward the environment with a focus on climate change. This paper describes the development of the instrument and psychometric performance characteristics including reliability and validity. Data were gathered from 1576 middle school students from across the United States in 2014 to validate the instrument and establish the measurement properties of the instrument's scales. Factor analysis revealed two stable constructs representing beliefs and intentions, which were reconfirmed through multidimensional scaling and hierarchical cluster analysis techniques. Internal consistency reliability was found to be respectable for the survey as a whole as well as the two separate scales. The Climate Change Attitude Survey was created to fill a void in the measurement of middle school students' affective responses to the environment and climate change. Educators may find this survey useful for assessing pre- to post intervention attitude changes as well as for identifying differences in selected groups of students. Further development is targeted to include adding new constructs as well as testing the instrument with different population subgroups.
POLICE JUDGMENTS OF CULPABILITY AND HOMOPHOBIA

This study (a) presented 152 Texas police officers with a scenario in which the sexual orientation of a criminal suspect was manipulated (b) assessed homophobia in this sample, and (c) examined the relationship between homophobia and the officers’ judgments of the suspect’s culpability. Although the officers were no more likely to report that they would arrest a gay suspect than a heterosexual suspect, those who read a scenario with a gay suspect were more likely to indicate that they thought he should be convicted than those presented with a heterosexual suspect. In general, the officers in our study endorsed homophobic attitudes and those officers who reported higher levels of homophobia were more likely to think that the gay suspect should be convicted.
Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study)

OBJECTIVE This study evaluated the effects of testosterone replacement therapy (TRT) on insulin resistance, cardiovascular risk factors, and symptoms in hypogonadal men with type 2 diabetes and/or metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS The efficacy, safety, and tolerability of a novel transdermal 2% testosterone gel was evaluated over 12 months in 220 hypogonadal men with type 2 diabetes and/or MetS in a multicenter, prospective, randomized, double-blind, placebo-controlled study. The primary outcome was mean change from baseline in homeostasis model assessment of insulin resistance (HOMA-IR). Secondary outcomes were measures of body composition, glycemic control, lipids, and sexual function. Efficacy results focused primarily on months 0−6 (phase 1; no changes in medication allowed). Medication changes were allowed in phase 2 (months 6−12). RESULTS TRT reduced HOMA-IR in the overall population by 15.2% at 6 months (P = 0.018) and 16.4% at 12 months (P = 0.006). In type 2 diabetic patients, glycemic control was significantly better in the TRT group than the placebo group at month 9 (HbA1c: treatment difference, −0.446%; P = 0.035). Improvements in total and LDL cholesterol, lipoprotein a (Lpa), body composition, libido, and sexual function occurred in selected patient groups. There were no significant differences between groups in the frequencies of adverse events (AEs) or serious AEs. The majority of AEs (>95%) were mild or moderate. CONCLUSIONS Over a 6-month period, transdermal TRT was associated with beneficial effects on insulin resistance, total and LDL-cholesterol, Lpa, and sexual health in hypogonadal men with type 2 diabetes and/or MetS.
Detection of ALK-Positive Non–Small-Cell Lung Cancers on Cytological Specimens: High Accuracy of Immunocytochemistry with the 5A4 Clone

Introduction: Lung cancer is often diagnosed by cytology, necessitating predictive molecular marker analyses on cytological specimens. The gold standard for detection of predictive anaplastic lymphoma kinase (ALK)-rearrangements is fluorescence in situ hybridization (FISH), but FISH is both expensive and often challenging to interpret. The aim of our study was to investigate the accuracy of ALK immunocytochemistry (ICC) on cytological specimens of non–small-cell lung cancers (NSCLCs). Methods: Forty-one cytological specimens with available ALK FISH results were retrospectively analyzed with the 5A4 monoclonal antibody (Novocastra; Leica Biosystems) on a fully automated slide stainer. The specimens were enriched for ALK FISH-positive NSCLCs (14 of 41; 34.1%). Evaluation of the ICC staining was performed blinded to the FISH results. The staining intensity and the percentage of stained cancer cells were recorded. Any ICC staining was regarded as a positive result. The ALK ICC results were compared with the FISH results. In case of a discrepancy the ICC-stained slide and the FISH signals were reviewed. Results: ICC was evaluable on 40 of 41 specimens. Fifteen of 40 NSCLCs (37.5%) were ALK ICC-positive, with staining of the majority of cancer cells (median 100%; mean 82.3%). Twelve of the ICC-positive NSCLCs (80.0%) showed an intense staining (3+). Compared with the ALK FISH results, only one NSCLC was false-negative, and one false-positive by ICC, respectively. The sensitivity, specificity, and positive and negative predictive values for ALK ICC compared with ALK FISH were 93.3%, 96.0%, 93.3%, and 96%, respectively. Conclusion: ALK ICC is highly accurate for detecting ALK-rearranged NSCLCs.
Classical Probability in the Enlightenment

What did it mean to be reasonable in the Age of Reason? Classical probabilists from Jakob Bernouli through Pierre Simon Laplace intended their theory as an answer to this question--as "nothing more at bottom than good sense reduced to a calculus," in Laplace's words. In terms that can be easily grasped by nonmathematicians, Lorraine Daston demonstrates how this view profoundly shaped the internal development of probability theory and defined its applications.
Letter: ciclosporin or infliximab in acute ulcerative colitis ‐ still undecided; authors’ reply

*Department of Gastroenterology, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia. Department of Gastroenterology, St Vincent’s Hospital, Sydney, NSW, Australia. The Australian E-Health Research Centre, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia. CSIRO Preventative Health Flagship, Parkville, Melbourne, Victoria, Australia. CSIRO Mathematics and Information Sciences, Macquarie University, Sydney, NSW, Australia. **IBD Group, Queensland Institute of Medical Research and University of Queensland School of Medicine, Herston Campus, Brisbane, Queensland, Australia. E-mail: anthony.croft@gmail.com
Adherence to Mathematics Professional Standards and Instructional Design Criteria for Problem-Solving in Mathematics

This study investigated the extent to which teaching the recommended methods for problem-solving presented in third-grade mathematics textbooks adhered to the National Council of Teachers of Mathematics Standards and instructional design criteria. Results indicated that there were more variations than similarities within and across textbooks in meeting the Standards. In terms of the instructional design criteria, most were satisfied in only two textbooks and few discrepancies were evident across the textbooks that were evaluated. For example, instructional design criteria of clarity of objectives, sufficient teaching examples, and nonexamples were met in less than half of the textbooks. Additional findings and implications for practitioners meeting the diverse needs of students with learning problems are discussed.
Studies of iron deposits, inducible nitric oxide synthase and nitrotyrosine in a rat model for esophageal adenocarcinoma.

A rat model was developed recently in our laboratory to study the pathogenesis of Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC). Eight-week-old male Sprague-Dawley rats underwent esophagoduodenal anastomosis (EDA) to produce gastric and duodenal reflux in their distal esophagi. The rats were given iron dextran (50 mg of Fe/kg, i.p.) starting 2 weeks after surgery and this was continued once a month. BE was observed as early as week 3 and the incidence of BE and EAC increased with time: 58 and 17% at week 23; 91 and 73% at week 31. There was a progression in epithelial cell proliferation and inflammation from mild to severe in the distal one-third of the esophagus. Iron deposition in the esophagus also increased with time. Iron deposits in the stromal tissue adjacent to the epithelium in the distal one-third of the esophagus were associated with areas of severe inflammation. Immunohistochemical analysis showed positive inducible nitric oxide synthase (iNOS) expression in the stromal macrophages directly beneath the epithelium in the distal one-third of the esophagus in 36, 83 and 100% of the rats at weeks 17, 23 and 31, respectively. A significant increasing linear trend (P=0.001) was seen in nitrotyrosine immunostaining (number of positive cells/high power field) in the distal esophagus. Strong positive nitrotyrosine staining was seen in the macrophages and weaker positive staining was seen in the adjacent epithelium starting at week 17. Furthermore, iron supplemented rats killed at week 31 had significantly higher (P < 0.05) levels of inflammation, cell proliferation, iNOS and nitrotyrosine as well as more tumors in their distal esophagi than did rats that received no iron supplement. These results suggest that iron supplementation enhanced inflammation and the production of reactive oxygen and nitrogen species in the esophageal epithelium. These processes could contribute to the formation of BE and its progression to EAC.
EIGHT NEW MILKY WAY COMPANIONS DISCOVERED IN FIRST-YEAR DARK ENERGY SURVEY DATA

We report the discovery of eight new Milky Way companions in ∼ 1800 deg 2 ? > of optical imaging data collected during the first year of the Dark Energy Survey (DES). Each system is identified as a statistically significant over-density of individual stars consistent with the expected isochrone and luminosity function of an old and metal-poor stellar population. The objects span a wide range of absolute magnitudes (MV from − 2.2 ? > to − 7.4 mag ? > ), physical sizes ( 10 − 170 pc ? > ), and heliocentric distances ( 30 − 330 kpc ? > ). Based on the low surface brightnesses, large physical sizes, and/or large Galactocentric distances of these objects, several are likely to be new ultra-faint satellite galaxies of the Milky Way and/or Magellanic Clouds. We introduce a likelihood-based algorithm to search for and characterize stellar over-densities, as well as identify stars with high satellite membership probabilities. We also present completeness estimates for detecting ultra-faint galaxies of varying luminosities, sizes, and heliocentric distances in the first-year DES data.
Co-Authorship in Management and Organizational Studies: An Empirical and Network Analysis

In recent decades there has been growing interest in the nature and scale of scientific collaboration. Studies into co-authorship have taken two different approaches. The first one attempts to analyse the reasons why authors collaborate and the consequences of such decision (Laband and Tollison, 2000). The second approach is based on the idea that co-authorship creates a social network of researchers (Barabasi et al., 2002; Moody, 2004; Newman, 2001). In this study we have carried out an exploratory analysis of co-authorships in the field of management from the two aforementioned approaches. The results obtained show a growing tendency of the co-authored papers in the field of management, similar to what can be observed in other disciplines. Our study analyses some of the underpinning factors, which have been highlighted in the literature, explaining this tendency. Thus, the progressive quantitative character of research and the influence of the collaboration on the articles' impact are enhanced. The network analysis permits the exploration of the peculiarities of the management in comparison with other fields of knowledge, as well as the existing linkages between the most central and prominent authors within this discipline.
Association of body mass index with mortality in Chinese patients after percutaneous coronary intervention: A large single‐center data

BACKGROUND Although numerous studies, to date, have demonstrated a specific phenomenon called the "obesity paradox" in patients after percutaneous coronary intervention (PCI), studies performed in China thus far have consistently shown an absence of this phenomenon. HYPOTHESIS "Obesity paradox" does exist in Chinese PCI patients. METHODS 10 724 consecutive Chinese patients who had undergone PCI treatment at a single center from January 2013 to December 2013 were prospectively recruited. Patients were divided into four groups: underweight (body mass index [BMI<18.5 kg/m2 ]), normal weight (18.5 kg/m2 ≤BMI<24.0 kg/m2 ), overweight (24.0 kg/m2 ≤BMI<28.0 kg/m2 ), and obese (BMI≥28.0 kg/m2 ). Two-year clinical outcomes were compared across the groups. RESULTS Overall, mean (±SD) BMI of all the patients was 25.9±3.2 kg/m2 . The 2-year mortality across underweight, normal weight, overweight, and obese patients in different BMI groups was 2.2%, 1.7%, 1.1%, and 1.0%, respectively (P=.035). Kaplan-Meier curves revealed that normal weight patients had higher incidence of all-cause mortality than overweight and obese (P=.015 and P=.020, respectively). Multivariable Cox regression analysis indicated that overweight was an independent predictor of all-cause mortality compared with normal weight (HR 0.64, 95% CI 0.41-0.98, P=.042). CONCLUSIONS Overweight patients have lower risk of mortality after PCI treatment; therefore, the phenomenon of "obesity paradox" also seems to exist in Chinese PCI patients.
Many Faces of Parkinson’s Disease: Non-Motor Symptoms of Parkinson’s Disease

Parkinson’s disease (PD) is a multi-systemic disorder that is characterized by a combination of motor and non-motor symptoms (NMS). The dopaminergic neurodegeneration of PD is involved in the genesis of NMS, but other conditions and side effects of levodopa are also associated with NMS. NMS can develop at all stage of PD and rapid eyeball movement sleep behavior disorder (RBD), constipation, depression, and olfactory dysfunction are considered prodromal signs of PD. Many NMS related with motor deficits and cognitive dysfunction. Some NMS including olfactory dysfunction, RBD and abnormal stereopsis are associated with presence of other NMS of PD. In addition, several NMS can be helpful to differentiate between idiopathic PD and other parkinsonian disorders. Early recognition and management of NMS in PD patients is important for preserving quality of life.
Investigating the Effect of Large Wind Farms on Energy in the Atmosphere

This study presents a parameterization of the interaction between wind turbines and the atmosphere and estimates the global and regional atmospheric energy losses due to such interactions. The parameterization is based on the Blade Element Momentum theory, which calculates forces on turbine blades. Should wind supply the world’s energy needs, this parameterization estimates energy loss in the lowest 1 km of the atmosphere to be ~0.007%. This is an order of magnitude smaller than atmospheric energy loss from aerosol pollution and urbanization, and orders of magnitude less than the energy added to the atmosphere from doubling CO 2 . Also, the net heat added to the environment due to wind dissipation is much less than that added by thermal plants that the turbines displace.
Investigating Early Career Urban Teachers' Perspectives on and Experiences in Professional Development

Despite their interconnectedness, teacher education, teacher development, and teacher retention are often treated as discrete domains of inquiry. This article and the research on which it reports resist such compartmentalization and instead focus on relationships between teachers' pasts, presents, and futures. In particular, this qualitative study of 15 specialized teacher education program graduates examines urban teachers' perspectives on and experiences in professional development. Specific attention is paid to the role of professional development—in conjunction with other forces, including preservice preparation and workplace conditions—in shaping teachers' attitudes about their work and their professional futures. Findings illuminate four kinds of complexity underlying teachers' early career needs that are discussed and used to generate suggestions for how universities might better support teacher education program graduates to build rewarding and effective long-term careers in education.
Benzodiazepines, amnesia and sedation: Theoretical and clinical issues and controversies

The amnestic effect of benzodiazepines, first described in 1965, and the subsequent attempts to identify the precise nature of this effect, are reviewed. The difficulty in deciding to what extent this effect is secondary to the sedative action of these drugs is shown by the lack of agreement between studies. Nevertheless, it is concluded that, given the right experimental design, all benzodiazepines can be shown to cause an anterograde amnesia which is probably primarily a result of reduced attention or rehearsal and secondary to sedation. Its onset, degree and duration are influenced by dose, rate of absorption, route of administration, potency and the receptor occupancy rate of the particular benzodiazepine involved, but plasma elimination t½ appears to be relatively unimportant. The clinical relevance of this for the long‐term use of hypnotics and anxiolytics is not clear. Tolerance appears to be greater than for the anxiolytic but less than the sedative or anticonvulsant effect of benzodiazepines. It seems that transient amnestic effects could occur in chronic users related to post‐dose, peak benzodiazepine levels. The great variability in individual response means that transient amnesia is a potential adverse drug reaction in certain individuals taking benzodiazepines.