Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation between classification in risk categories and clinical aspects and outcomes 1

ABSTRACT Objective: to correlate classification in risk categories with the clinical profiles, outcomes and origins of patients. Method: analytical cross-sectional study conducted with 697 medical forms of adult patients. The variables included: age, sex, origin, signs and symptoms, exams, personal antecedents, classification in risk categories, medical specialties, and outcome. The Chi-square and likelihood ratio tests were used to associate classifications in risk categories with origin, signs and symptoms, exams, personal antecedents, medical specialty, and outcome. Results: most patients were women with an average age of 44.5 years. Pain and dyspnea were the symptoms most frequently reported while hypertension and diabetes mellitus were the most common comorbidities. Classifications in the green and yellow categories were the most frequent and hospital discharge the most common outcome. Patients classified in the red category presented the highest percentage of ambulance origin due to surgical reasons. Those classified in the orange and red categories also presented the highest percentage of hospitalization and death. Conclusion: correlation between clinical aspects and outcomes indicate there is a relationship between the complexity of components in the categories with greater severity, evidenced by the highest percentage of hospitalization and death.
Differences Between Persistent and Desistent Middle School Bullies

This study investigated differences in aggressive attitudes, academic achievement and discipline referrals between bullies and non-bullies in a sample of 261 6th and 7th grade students over a two-year period. Through the use of a peer nomination survey, 16 students were identified as bullies both years (persistent) and 21 were identified only in the first year (desistent). Across all students, aggressive attitudes were associated with poorer grades and more discipline infractions, but persistent bullies had the most aggressive attitudes and were more likely to get into trouble in school than desistent bullies or control students. Desistent bullies were more similar to control students than persistent bullies. These findings support the need to differentiate among middle school bullies and to focus attention on the aggressive attitudes of persistent bullies.
Patterns of Gene Expression in Drosophila InsP3 Receptor Mutant Larvae Reveal a Role for InsP3 Signaling in Carbohydrate and Energy Metabolism

Background The Inositol 1,4,5-trisphosphate receptor (InsP3R) is an InsP3 gated intracellular Ca2+-release channel. Characterization of Drosophila mutants for the InsP3R has demonstrated that InsP3-mediated Ca2+ release is required in Drosophila larvae for growth and viability. Methodology/Principal Findings To understand the molecular basis of these growth defects a genome wide microarray analysis has been carried out with larval RNA obtained from a strong InsP3R mutant combination in which 1504 independent genes were differentially regulated with a log2 of fold change of 1 or more and P<0.05. This was followed by similar transcript analyses from InsP3R mutants where growth defects were either suppressed by introduction of a dominant suppressor or rescued by ectopic expression of an InsP3R transgene in the Drosophila insulin like peptide-2 (Dilp2) producing cells. Conclusions/Significance These studies show that expression of transcripts related to carbohydrate and amine metabolism is altered in InsP3 receptor mutant larvae. Moreover, from a comparative analysis of genes that are regulated in the suppressed and rescued conditions with the mutant condition, it appears that the organism could use different combinations of pathways to restore a ‘normal’ growth state.
Preparing early childhood personnel to be pro‐active, policy‐making professionals

It can be readily acknowledged that early childhood personnel in Australia as in other parts of the world are amongst the most hardworking of any professional group. Their role is a demanding one requiring clear thinking, quick responses, is physically demanding and constantly challenging. Early childhood staff in Australia have been required to respond to a number of numerous changes as, for example, when governments have required them in addition to working with children to work with families, to work in the community and to manage all of these with fewer resources. It is to the credit of the profession that teachers have responded positively. It can be said quite clearly that teachers at no other level (primary or secondary) have been required to do what the early childhood profession has had to do! This paper considers the responsibilities, knowledge and skills of the early childhood professional.
When Membership Gives Strength to Act: Inclusion of the Group Into the Self and Feeling of Personal Agency

ABSTRACT Identity fusion theory suggests that merging groups into one’s personal identity should result in heightened levels of group agency. Research on the self-expansion model complementarily indicates that including others into the self is linked to a greater feeling of self-efficacy. Across three correlational studies, we examined whether personal and group identity fusion is associated with stronger feelings of personal agency, and we propose that relatively stable feelings of clarity of self-concept would mediate this association. Individuals strongly fused with a country (Studies 1–3) and family (Study 2) exhibited greater feelings of agency and goal-adherence, and self-concept clarity emerged as a significant mediator of this association when controlling for group identification measures.
Enhanced Ventricular Untwisting During Exercise: A Mechanistic Manifestation of Elastic Recoil Described by Doppler Tissue Imaging

Background— The cascade of events by which early diastolic left ventricular (LV) filling increases with exercise is not fully elucidated. Doppler tissue imaging (DTI) can detect myocardial motion, including torsion, whereas color M-mode Doppler (CMM) can quantify LV intraventricular pressure gradients (IVPGs). Methods and Results— Twenty healthy volunteers underwent echocardiographic examination with DTI at rest and during submaximal supine bicycle exercise. We assessed LV long-/short-axis function, torsion, volume, inflow dynamics, and early diastolic IVPG derived from CMM data. LV torsion and untwisting velocity increased with exercise (torsion, 11±4° to 24±8°; untwisting velocity, −2.0±0.7 to −5.6±2.3 rad/s) that was associated with an increase in IVPG (1.4±0.5 to 3.7±1.2 mm Hg). Untwisting in normal subjects occurred during isovolumic relaxation and early filling, significantly before long-axis lengthening or radial expansion. The clinical feasibility of this method was tested in 7 patients with hypertrophic cardiomyopathy (HCM); torsion was higher at rest but did not increase with exercise (16±4° to 14±6°), whereas untwisting was delayed and unenhanced (−1.6±0.8 to −2.3±1.2 rad/s). In concert, IVPG was similar at rest (1.2±0.3 mm Hg), but the exercise response was blunted (1.6±0.8 mm Hg). In normal subjects and HCM patients, there was a similar linear relation between IVPG and untwisting rate, with an overall correlation coefficient of r=0.75 (P<0.0001). Conclusions— LV untwisting appears to be linked temporally with early diastolic base-to-apex pressure gradients, enhanced by exercise, which may assist efficient LV filling, an effect that appears blunted in HCM. Thus, LV torsion and subsequent rapid untwisting appear to be manifestations of elastic recoil, critically linking systolic contraction to diastolic filling.
The impact of affective factors related to work on the turnover intent of speech language pathologists in Texas

The Impact of Affective Factors Related to Work on the Turnover Intent of Speech Language Pathologists in Texas. (December 2007) Johnny R. O’Connor, Jr., B.S., Southern University and A&M College M.Ed., Southern University and A&M College M.B.A., Texas Southern University Chair of Advisory Committee: Dr. Toby M. Egan This study was an attempt to add to the existing research base, as well as fill in a gap in the literature with regard to speech language pathologists in public educational organizations in Texas. Variables explored in this study were recruitment, retention, career commitment, organizational commitment, job satisfaction, job overload, and turnover intent. The purpose of this study was to explore the relationship between recruitment, retention, career commitment, organizational commitment, job satisfaction, job overload, and the turnover intent of speech language pathologists in Texas. Additionally, this study sought to identify those factors that most influence the recruitment and retention of speech pathologists. A random sample of 500 speech pathologists was identified for participation in this study. Responses were elicited via Questionnaires, and consisted of eight sections: (a) demographic information and (b) seven previously validated and reliable instruments
Reduced bone density in patients with inflammatory bowel disease.

BACKGROUND: Reduced bone mineral density in patients with inflammatory bowel disease is thought to be due to disturbances in calcium homeostasis or the effects of corticosteroid treatment. AIMS: To assess the prevalence and mechanism of reduced bone mineral density in 79 patients with inflammatory bowel disease (44 with Crohn's disease, 35 with ulcerative colitis) who did not have significant risk factors for low bone densities. METHODS: Dual x ray absorptiometry was used to measure bone mineral density and serum and urinary markers of osteoblast (alkaline phosphatase, procollagen 1 carboxy terminal peptide and osteocalcin) and osteoclast (pyridinoline, deoxypyridinoline, and type 1 collagen carboxy terminal peptide) activities to assess bone turnover. RESULTS: There was a high prevalence of low bone mineral density (prevalence of T scores < -1.0 from 51%-77%; T scores < -2.5 (osteoporosis) from 17%-28%) with hips being more often affected than vertebrae (p < 0.001). Reduced bone mineral density did not relate to concurrent or past corticosteroid intake, or type, site, or severity of disease. Whereas calcium homeostasis was normal, bone markers showed increased bone resorption without a compensatory increase in bone formation. CONCLUSIONS: The greater prevalence of reduced hip bone mineral density, as opposed to vertebral, mineral density and the pattern of a selective increase in bone resorption contrasts with that found in other known causes of metabolic bone disease.
Effects of feeding level in late pregnancy and dietary protein concentration during early lactation on food intake, milk yield, liveweight change and nitrogen balance of cows

Summary Thirty-nine British Friesian cows and 17 British Friesian heifers were used to measure the effects on milk yield, food intake and digestion, and N balance of increasing the protein concentration in the diet from 111 to 147 g crude protein/kg dry matter during the first 16 weeks of lactation. The comparison was made for animals given food either ad lib. or at a level which allowed them to gain 0·5 kg/d during the 8 weeks before parturition, and for animals given ad lib. diets of either 60:40 or 40:60 hay: concentrate ratio during early lactation. Milk yield was increased by a higher protein concentration in the diet (P < 0·01) and the increase was evident from the first week of lactation. Mean increases over the first 8 weeks of lactation were 3 kg/d for animals on the diet of high roughage content and 7 kg/d for animals on the diet of low roughage content. A higher crude protein content in the diet also increased food intake (P < 0·05) and digestion (P < 0·05), and the increases were greater for animals given the diet of low compared with high roughage content. Level of feeding before parturition did not influence food intake or milk yield and there were no differences between cows and heifers in their response to treatments. N balance over the first 10 weeks of lactation averaged –13 g/d for cows and 6 g/d for heifers (P < 0·025). and was not significantly altered by treatments. Mean N balance of all animals was estimated to increase from –37 g/d immediately after parturition to zero at 8 weeks of lactation. The results demonstrate that an increased protein concentration in the diet during early lactation is associated with increased food intake and digestibility of food, which are in turn largely responsible for higher levels of milk production.
An Analysis of the Role of Teachers' Aides in a State Secondary School: Perceptions of Teaching Staff and Teachers' Aides.

In Victoria, Australia, one of the major roles of the teachers’ aide (TA) is to assist students with disabilities to access their education. Researchers have identified the inconsistencies in defining the roles of the TA, in a variety of settings, by TAs, teachers, parents, and other research participants. Four main themes that have been frequently reported in educational research related to the role of TAs formed the basis for this study: (a) inclusion in the school community, (b) curriculum, (c) classroom management, and (d) student support. Drawing on the results of a questionnaire administered to teachers and TAs at a government nonselective secondary school in Victoria, Australia, data were collected to explore the differing perspectives on the role of the TAs by the teaching staff and the TAs. In all, 65 individuals participated in this study. The participants formed 3 groups: TAs ( n = 10), teachers ( n = 49), and T/TAs ( n = 6; participants in this group had worked as both a teacher and TA). The results of the study showed a diversity of views across the 4 themes. In 3 of the 4 themes that included inclusion, classroom management, and student support, the 3 groups agreed on the role of the TA. In the remaining theme, curriculum, opinions varied significantly. The results of the study reveal that a concerted effort to clarify the role of TAs would be beneficial to all stakeholders.
Prevalence of ESBL Producing Klebsiella Species and Their in-Vitro Antimicrobial Susceptibility Pattern in A Tertiary Care Hospital

Infections caused by extended spectrum beta-lactamase (ESBL) producing Klebsiella spp. are associated with higher morbidity and mortality with limited treatment options. As there is no centralized national data in India, the prevalence of ESBL producing Klebsiella spp. is obtained from various scattered publications across the country. This varies widely from 10.10% to 87.00%. So it is important to do periodic surveillance at each institutional level to monitor the prevalence ESBL producers and take measures to contain their spread. This retrospective study was undertaken to identify the prevalence of ESBL producing Klebsiella spp. and their susceptibility pattern in a tertiary care hospital. Total of 209 Klebsiella spp. isolates were identified from various clinical specimens. Antimicrobial susceptibility pattern and detection of ESBL production was done as per standard protocols. Out of 209 Klebsiella spp. , 80 (38.28%) were found to be ESBL producers. All ESBL producing Klebsiella pneumoniae strains were susceptible to imipenem. The highest degree of resistance was observed with cefotaxime. The resistance level to aminoglycosides was low. The knowledge about the local prevalence of resistant bacteria helps to treat patients better by judicious use antibiotics. Strict implementation of infection control measures is essential to reduce the prevalence of resistant bacteria.
Aesthetic Understanding of Work and Organizational Life: Approaches and Research Developments

The aesthetic dimension of work and organizational life attracted the attention of organization scholars during the 1980s and 1990s, and its study burgeoned at the turn of the new millennium. There are today four main approaches to the study of organizational aesthetics: (i) the archaeological approach which privileges the symbolic dimension of aesthetic understanding; (ii) the empathic-logical approach which seeks to grasp the pathos of organizational life; (iii) the aesthetic approach which emphasizes the negotiation of organizational aesthetics; (iv) the artistic approach which examines flow, creativity, and playfulness. They all engage in an intellectual controversy with approaches to the study of organizations which privilege the mental, cognitive, and rational dimension of social action whilst neglecting the material, sensible, and emotional dimension of work relations in organizations. This article will illustrate and discuss these approaches by paying particular attention to the topics of the emancipation of people at work and the style of work and organizational practices.
The Attributable Mortality of Acute Kidney Injury: A Sequentially Matched Analysis*

Objective:Acute kidney injury in the critically ill is an independent risk factor for adverse outcome. The magnitude of the impact of acute kidney injury on outcome, however, is still unclear. This study aimed to estimate the excess mortality attributable to acute kidney injury. Design:We performed a sequentially matched analysis according to the day of acute kidney injury diagnosis after ICU admission. Patients with acute kidney injury and those without acute kidney injury were matched according to age, sex, ICU admission diagnosis, Simplified Acute Physiology Score II without renal and age components, and the propensity to develop acute kidney injury at each of the four matching time points. Setting:Cohort of 16 participating ICUs from the prospective Finnish Acute Kidney Injury study. Patients:Cohort of 2,719 consecutive patients with either emergency admission or elective postsurgical patients with an expected ICU stay greater than 24 hours. Interventions:None. Measurements and Main Results:Of the 2,719 patients included in the study, acute kidney injury developed in 1,081 patients (39.8%) according to the Kidney Disease: Improving Global Outcomes—definition during ICU treatment on days 1–5. Of these, 477 patients were successfully matched to 477 patients who did not develop acute kidney injury. The 90-day mortality of the matched patients with acute kidney injury was 125 of 477 (26.2%) compared with 84 of 477 (17.6%) for their matched controls without acute kidney injury. Thus, the absolute excess 90-day mortality attributable to acute kidney injury was estimated at 8.6 percentage points (95% CI, 2.6–17.6 percentage points). The population attributable risk (95% CI) of 90-day mortality associated with acute kidney injury was 19.6% (10.3–34.1%). Conclusions:In general ICU patients, the absolute excess 90-day mortality statistically attributable to acute kidney injury is substantial (8.6%), and the population attributable risk was nearly 20%. Our findings are useful in planning suitably powered future clinical trials to prevent and treat acute kidney injury in critically ill patients.
Comparative Study of the Susceptibilities of Major Epidemic Clones of Methicillin-Resistant Staphylococcus aureus to Oxacillin and to the New Broad-Spectrum Cephalosporin Ceftobiprole

ABSTRACT Multidrug-resistant strains of Staphylococcus aureus continue to increase in frequency worldwide, both in hospitals and in the community, raising serious problems for the chemotherapy of staphylococcal disease. Ceftobiprole (BPR; BAL9141), the active constituent of the prodrug ceftobiprole medocaril (BAL5788), is a new cephalosporin which was already shown to have powerful activity against a number of bacterial pathogens, including S. aureus. In an effort to test possible limits to the antibacterial spectrum and efficacy of BPR, we examined the susceptibilities of the relatively few pandemic methicillin-resistant S. aureus (MRSA) clones that are responsible for the great majority of cases of staphylococcal disease worldwide. We also included in the tests the highly oxacillin-resistant subpopulations that are present with low frequencies in the cultures of these clones. Such subpopulations may represent a natural reservoir from which MRSA strains with decreased susceptibility to BPR may emerge in the future. We also tested the efficacy of BPR against MRSA strains with reduced susceptibility to vancomycin and against MRSA strains carrying the enterococcal vancomycin resistance gene complex. BPR was shown to be uniformly effective against all these resistant MRSA strains, and the mechanism of superb antimicrobial activity correlated with the strikingly increased affinity of the cephalosporin against penicillin-binding protein 2A, the protein product of the antibiotic resistance determinant mecA.
Cloning and characterization of Pseudomonas sp. strain DNT genes for 2,4-dinitrotoluene degradation

The degradation of 2,4-dinitrotoluene (DNT) by Pseudomonas sp. strain DNT is initiated by a dioxygenase attack to yield 4-methyl-5-nitrocatechol (MNC) and nitrite. Subsequent oxidation of MNC by a monooxygenase results in the removal of the second molecule of nitrite, and further enzymatic reactions lead to ring fission. Initial studies on the molecular basis of DNT degradation in this strain revealed the presence of three plasmids. Mitomycin-derived mutants deficient in either DNT dioxygenase only or DNT dioxygenase and MNC monooxygenase were isolated. Plasmid profiles of mutant strains suggested that the mutations resulted from deletions in the largest plasmid. Total plasmid DNA partially digested by EcoRI was cloned into a broad-host-range cosmid vector, pCP13. Recombinant clones containing genes encoding DNT dioxygenase, MNC monooxygenase, and 2,4,5-trihydroxytoluene oxygenase were characterized by identification of reaction products and the ability to complement mutants. Subcloning analysis suggests that the DNT dioxygenase is a multicomponent enzyme system and that the genes for the DNT pathway are organized in at least three different operons.
Conflict free coordination of SON functions in a Unified Management Framework: Demonstration of a proof of concept prototyping platform

This paper proposes the exploitation of a Unified Management Framework for coordinating (i.e. ensuring conflict-free and stable operation), multiple, autonomic control loops. The functionality is demonstrated through the instantiation to Self-Organizing Network (SON) coordination for managing LTE-Advanced Heterogeneous Network (HetNet) with relays.
Smad3 Sensitizes Hepatocelluar Carcinoma Cells to Cisplatin by Repressing Phosphorylation of AKT

Background: Heptocelluar carcinoma (HCC) is insensitive to chemotherapy due to limited bioavailability and acquired drug resistance. Smad3 plays dual roles by inhibiting cell growth initially and promoting the progression of advanced tumors in HCC. However, the role of smad3 in chemosensitivity of HCC remains elusive. Methods: The role of smad3 in chemosensitivity of HCC was measured by cell viability, apoptosis, plate colony formation assays and xenograft tumor models. Non-smad signaling was detected by Western blotting to search for the underlying mechanisms. Results: Smad3 enhanced the chemosensitivity of HCC cells to cisplatin. Smad3 upregulated p21Waf1/Cip1 and downregulated c-myc and bcl2 with the treatment of cisplatin. Moreover, overexpression of smad3 repressed the phosphorylation of AKT, and vice versa. Inhibition of PI3K/AKT pathway by LY294002 restored chemosensitivity of smad3-deficiency cells to cisplatin in HCC. Conclusion: Smad3 sensitizes HCC cells to the effects of cisplatin by repressing phosphorylation of AKT and combination of inhibitor of AKT pathway and conventional chemotherapy may be a potential way to solve drug resistance in HCC.