Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of an innovative method, based on tilt sensing, for the assessment of activity and body position

Since there is less movement during sleep than during wake, the recording of body movements by actigraphy has been used to indirectly evaluate the sleep–wake cycle. In general, most actigraphic devices are placed on the wrist and their measures are based on acceleration detection. Here, we propose an alternative way of measuring actigraphy at the level of the arm for joint evaluation of activity and body position. This method analyzes the tilt of three axes, scoring activity as the cumulative change of degrees per minute with respect to the previous sampling, and measuring arm tilt for the body position inference. In this study, subjects (N = 13) went about their daily routine for 7 days, kept daily sleep logs, wore three ambulatory monitoring devices and collected sequential saliva samples during evenings for the measurement of dim light melatonin onset (DLMO). These devices measured motor activity (arm activity, AA) and body position (P) using the tilt sensing of the arm, with acceleration (wrist acceleration, WA) and skin temperature at wrist level (WT). Cosinor, Fourier and non-parametric rhythmic analyses were performed for the different variables, and the results were compared by the ANOVA test. Linear correlations were also performed between actimetry methods (AA and WA) and WT. The AA and WA suitability for circadian phase prediction and for evaluating the sleep–wake cycle was assessed by comparison with the DLMO and sleep logs, respectively. All correlations between rhythmic parameters obtained from AA and WA were highly significant. Only parameters related to activity levels, such as mesor, RA (relative amplitude), VL5 and VM10 (value for the 5 and 10 consecutive hours of minimum and maximum activity, respectively) showed significant differences between AA and WA records. However, when a correlation analysis was performed on the phase markers acrophase, mid-time for the 10 consecutive hours of highest (M10) and mid-time for the five consecutive hours of lowest activity (L5) with DLMO, all of them showed a significant correlation for AA (R = 0.607, p = 0.028; R = 0.582, p = 0.037; R = 0.620, p = 0.031, respectively), while for WA, only acrophase did (R = 0.621, p = 0.031). Regarding sleep detection, WA showed higher specificity than AA (0.95 ± 0.01 versus 0.86 ± 0.02), while the agreement rate and sensitivity were higher for AA (0.76 ± 0.02 versus 0.66 ± 0.02 and 0.71 ± 0.03 versus 0.53 ± 0.03, respectively). Cohen’s kappa coefficient also presented the highest values for AA (0.49 ± 0.04) and AP (0.64 ± 0.04), followed by WT (0.45 ± 0.06) and WA (0.37 ± 0.04). The findings demonstrate that this alternative actigraphy method (AA), based on tilt sensing of the arm, can be used to reliably evaluate the activity and sleep–wake rhythm, since it presents a higher agreement rate and sensitivity for detecting sleep, at the same time allows the detection of body position and improves circadian phase assessment compared to the classical actigraphic method based on wrist acceleration.
Blind Vision: The Neuroscience of Visual Impairment

Can a blind person see? The very idea seems paradoxical. And yet, if we conceive of "seeing" as the ability to generate internal mental representations that may contain visual details, the idea of blind vision becomes a concept subject to investigation. In this book, Zaira Cattaneo and Tomaso Vecchi examine the effects of blindness and other types of visual deficit on the development and functioning of the human cognitive system. Drawing on behavioral and neurophysiological data, Cattaneo and Vecchi analyze research on mental imagery, spatial cognition, and compensatory mechanisms at the sensorial, cognitive, and cortical levels in individuals with complete or profound visual impairment. They find that our brain does not need our eyes to "see. " Cattaneo and Vecchi address critical questions of broad importance: the relationship of visual perception to imagery and working memory and the extent to which mental imagery depends on normal vision; the functional and neural relationships between vision and the other senses; the specific aspects of the visual experience that are crucial to cognitive development or specific cognitive mechanisms; and the extraordinary plasticity of the brain -- as illustrated by the way that, in the blind, the visual cortex may be reorganized to support other perceptual or cognitive funtions. In the absence of vision, the other senses work as functional substitutes and are often improved. With Blind Vision, Cattaneo and Vecchi take on the "tyranny of the visual," pointing to the importance of the other senses in cognition.
Genealogy, Virtuality, War (1651/1976)

This article recounts Foucault’s critical reevaluation of Thomas Hobbes in his 1975-76 lecture course, published as Society Must Be Defended (2003). In probing Hobbes’ pivotal role in the foundation of the modern nation-state, Foucault delineates the ”philosophico-juridical” discourse of Leviathan from the ”historico-political” discourses of the English insurrectionists whose uncompromising demands were ultimately paved over by the more conventional seventeenth century debate between royalists and parliamentarians. In his most sustained engagement with political philosophy proper, Foucault effectively severs the two co-constitutive terms, enumerating the damning consequences of thinking politics apart from history and philosophy apart from the laws and codes that had been “born in the mud and blood of battles. ” Displacing himself in the archive, Foucault doubles the Levellers and Diggers’ efforts to restage the violent conquests that undergird our seemingly calm governmental regimes. This doubling, I argue, evinces the profound influence of Deleuze’s innovative ontology of time on Foucault’s genealogical method. Foucault’s research strategy takes a fundamental turn towards specific techniques of cultural memory in the wake of his colleague’s radical reconceptualization of virtuality, difference, and repetition. To this end, I take up Foucault’s review essay ”Theatrum Philosophicum” and his comments on method in ”Nietzsche, Genealogy, History” in order to draw an analogy between what he does in 1976 and what the Levellers and Diggers were doing in 1651. In the final analysis, genealogy means war, and, in this war, it is the very being of the virtual itself that is at stake.
Convergence Analysis of the Graph Allen-Cahn Scheme

Graph partitioning problems have a wide range of applications in machine learning. This work analyzes convergence conditions for a class of diﬀuse interface algorithm [A.L. Bertozzi and A. Flenner, Multiscale Modeling & Simulation , 10(3):1090 1118, 2012] for binary and multi-class partitioning. Using techniques from numerical PDE and convex optimization, convergence and monotonicity are shown for a class of schemes under a graph-independent timestep restriction. We also analyze the eﬀects of spectral truncation, a common technique used to save computational cost. Convergence of the scheme with spectral truncation is also proved under a timestep restriction inversely proportional to the size of the graph. Moreover, this restriction is shown to be sharp in a worst case. Various numerical experiments are done to compare theoretical results with practical performance.
The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior

A major challenge for the successful treatment of drug addiction is the long-lasting susceptibility to relapse and multiple processes that have been implicated in the compulsion to resume drug intake during abstinence. Recently, the orexin/hypocretin (Orx/Hcrt) system has been shown to play a role in drug-seeking behavior. The Orx/Hcrt system regulates a wide range of physiological processes, including feeding, energy metabolism, and arousal. It has also been shown to be recruited by drugs of abuse. Orx/Hcrt neurons are predominantly located in the lateral hypothalamus that projects to the paraventricular nucleus of the thalamus (PVT), a region that has been identified as a “way-station” that processes information and then modulates the mesolimbic reward and extrahypothalamic stress systems. Although not thought to be part of the “drug addiction circuitry”, recent evidence indicates that the PVT is involved in the modulation of reward function in general and drug-directed behavior in particular. Evidence indicates a role for Orx/Hcrt transmission in the PVT in the modulation of reward function in general and drug-directed behavior in particular. One hypothesis is that following repeated drug exposure, the Orx/Hcrt system acquires a preferential role in mediating the effects of drugs vs. natural rewards. The present review discusses recent findings that suggest maladaptive recruitment of the PVT by drugs of abuse, specifically Orx/Hcrt-PVT neurotransmission.
The primate subthalamic nucleus. I. Functional properties in intact animals.

1. The present study tests several key aspects of the current model of the intrinsic circuitry of the basal ganglia, in particular the degree to which basal ganglia-thalamocortical circuits are functionally segregated at the level of the subthalamic nucleus (STN). To this end the responses of STN cells to somatosensory examination (n = 301 cells), the polarity and latencies of neuronal responses to passive and active movements (n = 223 cells), responses to microstimulation (n = 1589 sites), and cross-correlation functions of pairs of neighboring neurons (n = 72 pairs) were studied in STNs of three African green monkeys. 2. The activity of 55% of cells examined in STN was briskly modulated in response to passive movements of individual contralateral body parts. Of these, 86% responded to passive joint rotation of muscle palpation, but in some cases (25% of responding cells) responses were also elicited by light touch. In 91% of the responding cells responses were elicited by manipulations around a single joint only. 3. The caudoventral sector in STN was largely devoid of cells with responses to somatosensory stimulation. Within the rostrodorsal zone a lateral region containing neurons that responded to arm movements and a more medial region with neurons responding to leg movement were found. Cells responding to orofacial movements were located more dorsally and rostrally. Neurons with similar responses to active and passive movements of the limbs tended to be clustered within "arm" and "leg" zones. 4. Of identified arm cells in STN (n = 80), 36% responded to the application of torque pulses to the elbow (43 responses overall). Forty-eight percent of these cells responded to both extension and flexion torques. Ninety-three percent of the responses were initial increases in discharge, which characteristically occurred earlier and were shorter than initial decreases. Fifty-three percent of the responses were biphasic or multiphasic. 5. During active step tracking movements 40% of STN arm cells (n = 53 cells) responded with significant changes in activity. Thirty-six percent of these cells showed responses with both extension and flexion movements. Of the responses, 90% were increases in discharge. Only 14% of all responses were biphasic or multiphasic. Responses tended to occur around the time of movement onset (average latency 2 ms after movement onset). 6. Microstimulation (bipolar pulses, 40 microA, 200-500 ms train duration, 400 Hz) of the core of STN itself did not appear to produce movement.4+ synchronized activity in only 11% of pairs. (ABSTRACT TRUNCATED AT 400 WORDS)
Lung ventilation/perfusion SPECT in the artificially embolized pig.

UNLABELLED Planar lung scintigraphy is a standard method used for the diagnosis of lung embolism, but it is hampered by the high incidence of nondiagnostic tests. Ventilation/perfusion SPECT may possibly improve this situation. The objective of this study was to compare planar lung scintigraphy with ventilation/perfusion SPECT using pigs with artificially engendered lung emboli labeled with (201)Tl. METHODS Sixteen anesthetized pigs were each injected with zero to 4 latex emboli. Cylindric emboli were used in the first 7 pigs and flat 3-tailed emboli were used in the remaining 9 pigs. The pigs spontaneously inhaled 30 MBq (99m)Tc-diethylenetriaminepentaacetic acid aerosol for ventilation scintigraphy. Planar scintigraphy and SPECT were performed using a double-head gamma camera in (99m)Tc and (201)Tl windows. Immediately thereafter, 100 MBq (99m)Tc-labeled macroaggregated albumin were injected intravenously followed by SPECT and, finally, planar scintigraphy. The ventilation background was subtracted from the perfusion tomograms for calculation of a normalized ventilation/perfusion (V/P) quotient image set. RESULTS The cylindric emboli caused artifacts in the ventilation images; therefore, these were excluded from the final analysis. However, for the planar perfusion images of these pigs, sensitivity and specificity were 71% and 91%, respectively, whereas SPECT yielded 100% for both. For the 3-tailed emboli and ventilation/perfusion images, the sensitivity and specificity were 64% and 79%, respectively, for the planar modality, whereas SPECT yielded values of 91% and 87%, respectively. CONCLUSION V/P SPECT may improve the diagnostic power of lung scintigraphy.
Small signal dynamic characterization of HID lamps

In the literature, several low-signal dynamic models for fluorescent lamps have been presented. These models can be used to analyze the lamp-ballast interaction in high frequency electronic ballasts. However, the small signal characteristics of HID lamps differ from those of fluorescent lamps, so the models described in previous literature cannot be applied to the analysis of HID lamp ballasts. In the present paper the small-signal characteristics of a mercury vapor lamp and a high pressure sodium lamp are obtained and compared to the typical characteristics of fluorescent lamps. The main differences between HID and fluorescent lamp small-signal characteristics are remarked upon. The key points for the stability analysis of the lamp-ballast system are also addressed in this paper. Using the multi-frequency averaging technique the interaction between a high pressure sodium lamp and a resonant inverter is analyzed and verified using a laboratory prototype.
The Fall of the Labor Share and the Rise of Superstar Firms

The fall of labor’s share of GDP in the United States and many other countries in recent decades is well documented but its causes remain uncertain. Existing empirical assessments typically rely on industry or macro data, obscuring heterogeneity among firms. In this article, we analyze micro panel data from the U.S. Economic Census since 1982 and document empirical patterns to assess a new interpretation of the fall in the labor share based on the rise of “superstar firms. ” If globalization or technological changes push sales toward the most productive firms in each industry, product market concentration will rise as industries become increasingly dominated by superstar firms, which have high markups and a low labor share of value added. We empirically assess seven predictions of this hypothesis: (i) industry sales will increasingly concentrate in a small number of firms; (ii) industries where concentration rises most will have the largest declines in the labor share; (iii) the fall in the labor share will be driven largely by reallocation rather than a fall in the unweighted mean labor share across all firms; (iv) the between-firm reallocation component of the fall in the labor share will be greatest in the sectors with the largest increases in market concentration; (v) the industries that are becoming more concentrated will exhibit faster growth of productivity; (vi) the aggregate markup will rise more than the typical firm’s markup; and (vii) these patterns should be observed not only in U.S. firms but also internationally. We find support for all of these predictions.
Awareness of kidney disease in the US population: findings from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2000.

BACKGROUND The prevalence of end-stage renal disease (ESRD) in the US population has been predicted to increase by 48% during the next decade and will pose a significant health cost burden. Early identification and treatment of chronic kidney disease (CKD) is necessary to delay progression from CKD to ESRD. CKD awareness among patients is crucial to early intervention programs, but its prevalence and characteristics in the noninstitutionalized US population are unknown. METHODS The National Health and Nutrition Examination Survey 1999 to 2000 was used to determine prevalence estimates of kidney disease awareness, as well as demographics, health care access, and comorbid characteristics, of participants with CKD. RESULTS In participants with CKD, 40.5% of patients with stage 1, 29.3% of patients with stage 2, 22.0% of patients with stage 3, and 44.5% of patients with stage 4 CKD were aware of their kidney disease, respectively. The aware and unaware groups did not differ by health care access. In multivariate regression modeling, lack of awareness was significantly associated with sex, race-ethnicity distribution, and hypertension. CONCLUSION Kidney disease awareness is low among a representative sample of the noninstitutionalized US population. Groups at greater risk for kidney disease, such as non-Hispanic blacks, patients with hypertension, and men, were more likely to be unaware of having kidney disease, even with health care access similar to that of the aware group. Increased efforts to promote kidney disease awareness are needed and probably should target primary care providers involved in the screening process.
Young children and adults use lexical principles to learn New Nouns

In two experiments, adults and children were tested in an object-selection task that examined whether Ss would (a) map a novel word onto a previously unnamed object and (b) extend the newly learned word to another exemplar. Experiment 3 was a control study. Ss overwhelmingly selected the novel object as the referent for the novel term, even though the new label was never explicitly linked to the novel object. Ss also extended the new term and allowed it to preempt yet another novel label from applying to the just-named object. The existence of several lexical principles and the power of indirect word learning is supported.
Repolarizing Responses of BKCa–Cav Complexes Are Distinctly Shaped by Their Cav Subunits

Large-conductance Ca2+- and voltage-activated potassium (BKCa) channels shape the firing pattern in many types of excitable cell through their repolarizing K+ conductance. The onset and duration of the BKCa-mediated currents typically initiated by action potentials (APs) appear to be cell-type specific and were shown to vary between 1 ms and up to a few tens of milliseconds. In recent work, we showed that reliable activation of BKCa channels under cellular conditions is enabled by their integration into complexes with voltage-activated Ca2+ (Cav) channels that provide Ca2+ ions at concentrations sufficiently high (≥10 μm) for activation of BKCa in the physiological voltage range. Formation of BKCa–Cav complexes is restricted to a subset of Cav channels, Cav1.2 (L-type) and Cav2.1/2.2 (P/Q- and N-type), which differ greatly in their expression pattern and gating properties. Here, we reconstituted distinct BKCa–Cav complexes in Xenopus oocytes and culture cells and used patch-clamp recordings to compare the functional properties of BKCa–Cav1.2 and BKCa–Cav2.1 complexes. Under steady-state conditions, K+ currents mediated by BKCa–Cav2.1 complexes exhibit a considerably faster rise time and reach maximum at potentials markedly more negative than complexes formed by BKCa and Cav1.2, in line with the distinct steady-state activation and gating kinetics of the two Cav subtypes. When AP waveforms were used as a voltage command, K+ currents mediated by BKCa–Cav2.1 occurred at shorter APs and lasted longer than that of BKCa–Cav1.2. These results demonstrate that the repolarizing K+ currents through BKCa–Cav complexes are shaped by the respective Cav subunit and that the distinct Cav channels may adapt BKCa currents to the particular requirements of distinct types of cell.
Separate Source Coding of Correlated Gaussian Remote Sources

We consider the separate source coding problem of correlated Gaussian observations . We consider the case that satisfy where are correlated Gaussian random variables and are independent additive Gaussian noises also independent of . On this coding system the determination problem of the rate distortion region remains open. In our previous work, we derived explicit outer and inner bounds of the rate distortion region. In this paper we show that when Gaussian correlated sources satisfy some condition, the outer bound coincides with the inner bound.
Weights of 2 distribution for smooth or piecewise smooth cone alternatives

We study the problem of testing a simple null hypothesis on multivariate normal mean vector against smooth or piecewise smooth cone alternatives. We show that the mixture weights of the distribution of the likelihood ratio test can be characterized as mixed volumes of the cone and its dual. The weights can be calculated by integration involving the second fundamental form on the boundary of the cone. We illustrate our technique by spherical cone and cone of non-negative de nite matrices.
A Combined Corpus and Systemic-Functional Analysis of the Problem-Solution Pattern in a Student and Professional Corpus of Technical Writing.

This article reports on research describing similarities and differences between expert and novice writing in the problem-solution pattern, a frequent rhetorical pattern of technical academic writing. A corpus of undergraduate student writing and one containing professional writing consisted of 80 and 60 recommendation reports, respectively, with each corpus totaling approximately 250,000 words. Drawing on two analytic perspectives, the methodology included searches for key words that provided linguistic evidence for the problem-solution pattern. A more delicate examination of the linguistic meanings encoded in the problemsolution reports involved a systemic-functional approach to analysis of evaluative texts, APPRAISAL (Martin, 2000, in press), as well as an analysis of the lexicogrammatical patterning of the key word problem within a framework of causal relations. Along with many similarities between the expert and the novice writing, findings highlight important differences in the use of problem within the causal relation patterns. Pedagogical implications are discussed. The problem-solution rhetorical pattern appears frequently in technical reports and other academic writing, perhaps most notably when the author introduces the issue that the report or paper discusses as a problem and then presents the main point of the paper as a solution. As a consequence, successful academic English writers draw on important aspects of their rhetorical knowledge and strategic competence when they exploit the linguistic resources required to express the problemsolution pattern in a range of academic writing. Accordingly, ESL/EFL teachers need to understand this common pattern, particularly in terms of how it is realized linguistically by novice and expert writers. This study