Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Organizational Ethical Culture Moderating the Influence of Leadership Style and the Effectiveness of Internal Control System Implementation on Government Employee Performance

This research aim to investigate the influence of leadership style and the effectiveness of the control system on the performance of government employees, while considering organizational ethical culture as a moderating variable. Quantitative approach, causal associative, path analysis model to assess variable relationships. The primary objective is to discern the direct and indirect effects of independent variables (exogenous) on the dependent variable (endogenous). Data analyzed using Partial Least Squares (PLS) with SMART PLS software, including outer and inner model testing. Research finds organizational ethical culture significantly influences and moderates leadership style's influence on employee performance. Leadership style, internal control system effectiveness don't significantly influence employee performance. Organizational ethical culture doesn't moderate this influence significantly.
Alexander's Disease: Clues to Diagnosis

The clinical, radiologic, neurophysiologic, and pathologic findings in 10 children with histologically proven Alexander's disease are described, and the presence of two broad clinical subgroups is confirmed. Macrocephaly, regression, and seizures are found in the infantile form, whereas bulbar signs predominate the so-called juvenile form. None of the clinical or neurophysiologic findings is pathognomonic, and radiologic features suggesting the diagnosis are not present in all cases. However, the combination of abnormalities may suggest the diagnosis and justify histologic confirmation. (J Child Neurol 1993;8:134-144).
Cost-Effectiveness of Genotype-Guided Warfarin Dosing for Patients With Atrial Fibrillation

Background—CYP2C9 and VKORC1 genotyping has been advocated as a means of improving the accuracy of warfarin dosing. However, the effectiveness of genotyping in improving anticoagulation control and reducing major bleeding has not yet been compellingly demonstrated. Genotyping currently costs $400 to $550. Methods and Results—We constructed a Markov model to evaluate whether and under what circumstances genetically-guided warfarin dosing could be cost-effective for newly diagnosed atrial fibrillation patients. Estimates of clinical event rates, treatment and adverse event costs, and utilities for health states were derived from the published literature. The cost-effectiveness of genetically-guided dosing was highly dependent on the assumed effectiveness of genotyping in increasing the amount of time patients spend appropriately anticoagulated. If genotyping increases the time spent in the target international normalized ratio range by <5 percentage points, its incremental cost-effectiveness ratio would be greater than $100 000 per quality-adjusted life year. The incremental cost-effectiveness ratio falls below $50 000 per quality-adjusted life year if genotyping increases the time spent in range by 9 percentage points. The results were also sensitive to assumptions about the rate of major bleeding events during treatment initiation and the cost of the test. Conclusions—Our results suggest that genotyping before warfarin initiation will be cost-effective for patients with atrial fibrillation only if it reduces out-of-range international normalized ratio values by more than 5 to 9 percentage points compared with usual care. Given the current uncertainty surrounding genotyping efficacy, caution should be taken in advocating the widespread adoption of this strategy.
Examination of Bacterial Inhibition Using a Catalytic DNA

Determination of accurate dosage of existing antibiotics and discovery of new antimicrobials or probiotics entail simple but effective methods that can conveniently track bacteria growth and inhibition. Here we explore the application of a previously reported fluorogenic E. coli-specific DNAzyme (catalytic DNA), RFD-EC1, as a molecular probe for monitoring bacterial inhibition exerted by antibiotics and for studying bacterial competition as a result of cohabitation. Because the DNAzyme method provides a convenient way to monitor the growth of E. coli, it is capable of determining the minimal inhibitory concentration (MIC) of antibiotics much faster than the conventional optical density (OD) method. In addition, since the target for RFD-EC1 is an extracellular protein molecule from E. coli, RFD-EC1 is able to identify pore-forming antibiotics or compounds that can cause membrane leakage. Finally, RFD-EC1 can be used to analyse the competition of cohabitating bacteria, specifically the inhibition of growth of E. coli by Bacillus subtilis. The current work represents the first exploration of a catalytic DNA for microbiological applications and showcases the utility of bacteria-sensing fluorogenic DNAzymes as simple molecular probes to facilitate antibiotic and probiotic research.
Contagion effect of global leaders' positive psychological capital on followers: does distance and quality of relationship matter?

A key assumption of effective international human resource management (IHRM) is that global leaders influence and serve as role models for their followers, regardless of the inherent distance (physical and frequency of interaction) between them in today's global context or the quality of the relationship. Although considerable attention has been devoted to cultural differences between global leaders and their diverse followers and teams, this study investigates the impact that distance and quality of the relationship has on a sample of a Fortune 100 multinational firm's global leaders' level of positive psychological capital (PsyCap) contagion effect on their followers located around the world. The results indicated such contagion at a distance existed, but the quality of the relationship did mediate this effect. Moreover, the potential undesirable effects of distance seemed to be buffered by the global leaders' PsyCap. The potential limitations, needed future research and practical implications for IHRM conclude the article.
Swirling flow implementation in a photobioreactor for batch and continuous cultures of porphyridium cruentum

Light is the main limiting factor in photoautotrophic‐intensive production of microorganisms, and improvement of its use is an important concern for photobioreactor design and operation. Swirling flows, which are known to improve mass and photon transfers, were applied to annular light chambers of a photobioreactor and studied by simulation and microalgal culture. Two hydrodynamic conditions were compared: axial flow generating poor radial mixing, and tangential flow generating three‐dimensional swirling motion. Batch and continuous cultures of the Rhodophyte Porphyridium cruentum were performed in a 100‐L, 1.5‐m2, fully controlled photobioreactor with eight light chambers. The inlet design of these chambers was modified to create the hydrodynamic conditions for comparison. Various intensities of swirling motion were used, characterized by the velocity factor (VF), defined as the ratio between annular chamber flow and inlet aperture sections. Experiments were performed within the range of photon flux densities (PFD) optimizing the yield of light energy transformation into living substance for the species and the temperature used. Culture kinetics with swirling flows generated by apertures of VF = 2, 4, and 9 were compared with pseudoaxial VF = 2 chosen as reference. Batch cultures with VF = 4 swirling flow showed no significant difference, whereas continuous cultures proved more discriminating. Although no significant difference was obtained for VF = 2, a 7% increase of steady‐state productivity and a 26% decrease in time required to reach this steady state were obtained with VF = 4 swirling flow. This beneficial effect of swirling flow could have accounted for increased mixing. Conversely, VF = 9 swirling flow resulted in a 9% decrease of steady‐state productivity and a 9% increase in the time required to reach this steady state, a negative effect that could have accounted for increased shear stress. CO2 bioconversion yield at steady state showed a 34% increase for VF = 4. These results suggest that swirling motion makes microalgal cultures more efficient, provided that the resulting adverse effects remain acceptable. Experimental investigation was completed by a theoretical approach in which simulation of continuous cultures of P. cruentum was based on the hydrodynamic conditions achieved in the photobioreactor. Although the results obtained with pseudoaxial flow were correctly predicted, simulations with swirling flow showed a marked enhancement of productivity not observed experimentally. The influence of side effects induced by increased mixing (particularly hydrodynamic shear stress) was considered with respect to modeling assumptions. Comparison of experimental results with theoretical simulation provided a better understanding of the mixing effect, a key factor in improving the efficiency of such bioprocesses. © 2004 Wiley Periodicals, Inc. Biotechnol Bioeng 84: 544–551, 2003.
Leaf Oil Body Functions as a Subcellular Factory for the Production of a Phytoalexin in Arabidopsis1[W]

Leaf oil bodies are the source of a novel phytoalexin produced in response to fungal infection and senescence. Oil bodies are intracellular structures present in the seed and leaf cells of many land plants. Seed oil bodies are known to function as storage compartments for lipids. However, the physiological function of leaf oil bodies is unknown. Here, we show that leaf oil bodies function as subcellular factories for the production of a stable phytoalexin in response to fungal infection and senescence. Proteomic analysis of oil bodies prepared from Arabidopsis (Arabidopsis thaliana) leaves identified caleosin (CLO3) and α-dioxygenase (α-DOX1). Both CLO3 and α-DOX1 were localized on the surface of oil bodies. Infection with the pathogenic fungus Colletotrichum higginsianum promoted the formation of CLO3- and α-DOX1-positive oil bodies in perilesional areas surrounding the site of infection. α-DOX1 catalyzes the reaction from α-linolenic acid (a major fatty acid component of oil bodies) to an unstable compound, 2-hydroperoxy-octadecatrienoic acid (2-HPOT). Intriguingly, a combination of α-DOX1 and CLO3 produced a stable compound, 2-hydroxy-octadecatrienoic acid (2-HOT), from α-linolenic acid. This suggests that the colocalization of α-DOX1 and CLO3 on oil bodies might prevent the degradation of unstable 2-HPOT by efficiently converting 2-HPOT into the stable compound 2-HOT. We found that 2-HOT had antifungal activity against members of the genus Colletotrichum and that infection with C. higginsianum induced 2-HOT production. These results defined 2-HOT as an Arabidopsis phytoalexin. This study provides, to our knowledge, the first evidence that leaf oil bodies produce a phytoalexin under a pathological condition, which suggests a new mechanism of plant defense.
Dictionaries using variable-length keys and data, with applications

We consider the problem of maintaining a dynamic dictionary in which both the keys and the associated data are variable-length bit-strings. We present a dictionary structure based on hashing that supports constant time lookup and expected amortized constant time insertion and deletion. To store the key-data pairs (<i>s</i><inf>1</inf>, <i>t</i><inf>1</inf>) . (<i>s<inf>n</inf></i>, <i>t<inf>n</inf></i>), our dictionary structure uses <i>O(m)</i> bits where <i>m</i> = Σ(max(|<i>s</i><inf><i>i</i></inf>| -- log <i>n</i>, 1) + |<i>t</i><inf><i>i</i></inf>| and |<i>s</i><inf><i>i</i></inf>| is the length of bit string <i>s</i><inf><i>i</i></inf>. We assume a word length <i>w</i> > log <i>m</i>. We present several applications, including representations for semi-dynamic graphs, ordered sets for integers in a bounded range, cardinal trees with varying cardinality, and simplicial meshes of <i>k</i> dimensions. These results either generalize or simplify previous results.
Assessment of the integration of an organic Rankine cycle for waste heat recovery from bleed air for implementation on board an aircraft

This project assesses the possibility of putting an organic Rankine cycle on board an aircraft for waste heat recovery using bleed air coming from the engine’s compressor as a heat source. Into this task the main subject taken into account was the weight of the system, since this will mean a trade-off between the power generated and the extra weight that is necessary to add. In recent years, little research on waste heat recovery on aircraft has been done. The main source of heat for these systems comes from the engine and not from the bleed air as in this project but in all cases penalties like changes in engine design, excessive weight from the heat exchangers and a loss in thrust were faced. On the other side, some of these penalties were surpassed by the amount of power that the organic Rankine cycles provided. To develop this project a model was designed on MATLAB varying the mass flow of the organic fluid to find out for the best arrangement that gives the most power output with the less weight. The model was performed under cruise conditions from an Airbus A320, a single aisle aircraft. The ORC was assessed in two locations; before the entrance of the precooler, a system that cools down the air before going into the pneumatic system, and before the air conditioning (AC) packs. The results show that heat recovery is possible only when the ORC is placed before the precooler but certain conditions need to be met so the energy balances result in positive outcomes. Current techniques were used to estimate the weight of the heat exchangers but improvements of these or availability of new materials in the future will increase the amount of energy that could be saved. The implementation of an ORC using the bleed system gives an option to recover wasted energy from aircraft since the conditions available are suitable for the system.
The Potential Use of Pharmacological Agents to Modulate Orthodontic Tooth Movement (OTM)

The biological processes that come into play during orthodontic tooth movement (OTM) have been shown to be influenced by a variety of pharmacological agents. The effects of such agents are of particular relevance to the clinician as the rate of tooth movement can be accelerated or reduced as a result. This review aims to provide an overview of recent insights into drug-mediated effects and the potential use of drugs to influence the rate of tooth movement during orthodontic treatment. The limitations of current experimental models and the need for well-designed clinical and pre-clinical studies are also discussed.
CORRELATION AND REGRESSION ANALYSIS IN DIFFERENT GENOTYPES OF SUNFLOWER (HELIANTHUS ANNUUS L.)

In 2017, a study at the Oil Seeds Research Section in Tandojam analyzed growth and yield across eight sunflower genotypes: Corolla, Melbour, Vulgare, Turkish, Samson-30, Sputnik, HO-1, and Parson. Using a randomized complete block design with three replications, significant variations were discovered in days to flowering and maturity, plant height, head diameter, number of seeds per head, seed yield, and seed index, emphasizing the distinct performance of each genotype. Advanced genotypes like Sputnik and HO-1 required more days to flower, with Parson and Sputnik showing the latest maturity. Turkish plants were notably taller, while Parson had the shortest stature. Parson and HO-1 stood out with larger head diameters and higher seed indexes, with Parson also leading in seed yield, suggesting their high breeding value. Positive correlations among various growth and yield parameters underscore the potential of these genotypes in breeding programs aimed at improving sunflower yields. This concise analysis highlights the diversity and breeding prospects within sunflower genotypes, offering valuable insights for future genetic improvement efforts.
Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer

Current therapies for the treatment of pancreatic cancer are limited. The limitations of this type of treatment are abundant. The majority of chemotherapeutic agents used in clinics are highly toxic to both tumor cells and normal tissues due to the lack of specificity. Resistance can develop due to overexposure of these agents. To address these issues, these agents must be made more exclusive toward the tumor site. We have developed a macromolecular carrier based on the sequence of the biopolymer elastin-like polypeptide (ELP) that is able to aggregate upon reaching the externally heated tumor environment. This carrier is specific to the tumor as it only aggregates at the heated tumor site. ELP is soluble below its transition temperature but will aggregate when the temperature is raised above its transition temperature. ELP was modified by p21, a cell cycle inhibitory peptide, and the addition of Bac, a cell-penetrating peptide with nuclear localization capabilities. In this study, p21-ELP-Bac and its control, ELP-p21, were used in cell proliferation studies using the pancreatic cancer cell lines Panc-1, MiaPaca-2, and S2013. ELP-p21 had little effect on proliferation, while the half maximal inhibitory concentration of p21-ELP-Bac was ∼30 μM. As translocation across the plasma membrane is a limiting step for delivery of macromolecules, these polypeptides were utilized in a pancreatic xenograft model to study the plasma clearance, biodistribution, tumor accumulation, and tumor reduction capabilities of the polypeptide with and without a cell-penetrating peptide.
Local Low-Dose Lovastatin Delivery Improves the Bone-Healing Defect Caused by Nf1 Loss of Function in Osteoblasts

Postfracture tibial nonunion (pseudoarthrosis) leads to lifelong disability in patients with neurofibromatosis type I (NF1), a disorder caused by mutations in the NF1 gene. To determine the contribution of NF1 in bone healing, we assessed bone healing in the Nf1 ob−/− conditional mouse model lacking Nf1 specifically in osteoblasts. A closed distal tibia fracture protocol and a longitudinal study design were used. During the 21‐ to 28‐day postfracture period, callus volume, as expected, decreased in wild‐type but not in Nf1 ob−/− mice, suggesting delayed healing. At these two time points, bone volume (BV/TV) and volumetric bone mineral density (vBMD) measured by 3D micro–computed tomography were decreased in Nf1 ob−/− callus‐bridging cortices and trabecular compartments compared with wild‐type controls. Histomorphometric analyses revealed the presence of cartilaginous remnants, a high amount of osteoid, and increased osteoclast surfaces in Nf1 ob−/− calluses 21 days after fracture, which was accompanied by increased expression of osteopontin, Rankl, and Tgfβ. Callus strength measured by three‐point bending 28 days after fracture was reduced in Nf1 ob−/− versus wild‐type calluses. Importantly, from a clinical point of view, this defect of callus maturation and strength could be ameliorated by local delivery of low‐dose lovastatin microparticles, which successfully decreased osteoid volume and cartilaginous remnant number and increased callus BV/TV and strength in mutant mice. These results thus indicate that the dysfunctions caused by loss of Nf1 in osteoblasts impair callus maturation and weaken callus mechanical properties and suggest that local delivery of low‐dose lovastatin may improve bone healing in NF1 patients. © 2010 American Society for Bone and Mineral Research
Halal Awareness, Brand Image, and Viral Marketing: Three Key Factors Influencing Purchasing Decisions for Halal Skin Care and Cosmetics Products in Pontianak

This research aims to determine the influence of halal awareness, brand image, and viral marketing on the purchasing decisions of halal skincare and cosmetic products (a study on Generation Z in the environment of Muhammadiyah University Pontianak). The research is conducted within the Muhammadiyah University Pontianak environment. The population of this study includes all students of Muhammadiyah University Pontianak born between the years 1995-2010. The sample for this research consists of 200 students from Muhammadiyah University Pontianak. The data collection technique used is a questionnaire employing a Likert scale. The data analysis technique in this research uses Structural Equation Modeling (SEM) PLS with the SmartPLS Version 3.2. 9 program. The results of this research show that halal awareness and brand image do not have a significant influence on purchasing decisions, whereas viral marketing has a positive and significant impact on purchasing decisions for halal skincare and cosmetic products among Generation Z in the Muhammadiyah University Pontianak environment. This study contributes theoretically by exploring the influence of halal product awareness, brand image, and viral marketing variables on purchasing decisions among Generation Z in a university setting. The findings enhance insights into academic literature related to halal skincare and cosmetics, even though halal product awareness and brand image are not significant. Practically, these findings provide guidance for industry practitioners to enhance marketing strategies, especially in the context of viral marketing that has proven to have a positive impact on purchasing decisions. The novelty of the research lies in its focus on Generation Z and the use of the Structural Equation Modeling (SEM) PLS analysis method, contributing to theoretical, practical, and methodological understanding in the context of marketing halal skincare and cosmetic products among Generation Z in a university environment.
Restriction endonuclease analysis of clinical Pseudomonas aeruginosa strains: useful epidemiologic data from a simple and rapid method

Newer genetic techniques have replaced phenotypic methods of subtyping Pseudomonas aeruginosa strains. Widespread application of newer methodologies, however, may be limited by technologic complexity and the cost of equipment. We conducted restriction endonuclease analysis (REA) of sheared genomic DNAs from 48 clinical P. aeruginosa strains using the enzyme SalI and electrophoresis in horizontal, low-concentration (0.3 to 0.6%) agarose gels. Each REA profile consisted of a smear of lower-molecular-mass bands as well as a countable number of well-resolved bands in the 8.3- to 48.5-kbp range which could easily be compared when isolates were run side-by-side on the same gel. In general, the REA patterns of strains recovered from different patients differed by at least seven bands, and those of serial isolates from individual patients were identical or differed by, at most, two bands over this 8.3- to 48.5-kbp range. REA of strains already subtyped by field inversion gel electrophoresis revealed that the two techniques generally paralleled each other. Overall, some unrelated strains had similar REA profiles, but the relative simplicity and low cost of the approach coupled with the ability to demonstrate differences between most unrelated strains should make this type of REA an attractive first step in the investigation of institutional P. aeruginosa problems.