Miracle-dz/UniFAR-FTUs huggingface dataset:
Contrasting Internal Structures: Photon and Electron

We develop a conceptual model for the internal structures of the photon and electron, based on the cordus model. The main differentiating feature between the photon and electron is identified as the way it deals with its field structures or hyff. The photon has a fibrillating relationship with its field, whereas the electron is a pulsating field-pump. The resulting model permits an explanation of the discrete (approximately quantised) electrostatic force, the propulsion mechanism for the speed of light, and the gravitational bending of light. These are side-effects and the larger advantage of this model is the potential to explain photon-electron interactions generally.
Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching

Dynamic cell movements and rearrangements are essential for the generation of the mammalian body plan, although relatively little is known about the genes that coordinate cell movement and cell fate. WAVE complexes are regulators of the actin cytoskeleton that couple extracellular signals to polarized cell movement. Here, we show that mouse embryos that lack Nap1, a regulatory component of the WAVE complex, arrest at midgestation and have defects in morphogenesis of all three embryonic germ layers. WAVE protein is not detectable in Nap1 mutants, and other components of the WAVE complex fail to localize to the surface of Nap1 mutant cells; thus loss of Nap1 appears to inactivate the WAVE complex in vivo. Nap1 mutants show specific morphogenetic defects: they fail to close the neural tube, fail to form a single heart tube (cardia bifida), and show delayed migration of endoderm and mesoderm. Other morphogenetic processes appear to proceed normally in the absence of Nap1/WAVE activity: the notochord, the layers of the heart, and the epithelial-to-mesenchymal transition (EMT) at gastrulation appear normal. A striking phenotype seen in approximately one quarter of Nap1 mutants is the duplication of the anteroposterior body axis. The axis duplications arise because Nap1 is required for the normal polarization and migration of cells of the Anterior Visceral Endoderm (AVE), an early extraembryonic organizer tissue. Thus, the Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo.
Approximating Sparse Covering Integer Programs Online

A covering integer program (CIP) is a mathematical program of the form: $$\begin{aligned} \min \{ c^\top \mathbf{x} \mid A\mathbf{x} \geq \mathbf{1},\; \mathbf{0} \leq \mathbf{x} \leq \mathbf{u},\; \mathbf{x} \in {\ensuremath{\mathbb{Z}}}^n\},\nonumber \end{aligned}$$ where $A \in R_{\geq 0}^{m \times n}, c, u \in {\ensuremath{\mathbb{R}}}_{\geq 0}^n$. In the online setting, the constraints (i.e., the rows of the constraint matrix A) arrive over time, and the algorithm can only increase the coordinates of x to maintain feasibility. As an intermediate step, we consider solving the covering linear program (CLP) online, where the requirement x∈ℤn is replaced by x∈ℝn. Our main results are (a) an O(logk)-competitive online algorithm for solving the CLP, and (b) an O(logk ·logl)-competitive randomized online algorithm for solving the CIP. Here k≤n and l≤m respectively denote the maximum number of non-zero entries in any row and column of the constraint matrix A. By a result of Feige and Korman, this is the best possible for polynomial-time online algorithms, even in the special case of set cover (where A∈{0,1}m ×n and c, u∈{0,1}n). The novel ingredient of our approach is to allow the dual variables to increase and decrease throughout the course of the algorithm. We show that the previous approaches, which either only raise dual variables, or lower duals only within a guess-and-double framework, cannot give a performance better than O(logn), even when each constraint only has a single variable (i.e., k=1).
Tooth size and morphology in twins.

OBJECTIVE To assess concordance of tooth size and occlusal morphology in monozygotic (identical) and dizygotic (non-identical) twins compared to unrelated controls in order to determine how much these dental traits are related to inheritance. METHODS Mesiodistal and bucco-lingual dimensions of tooth size in 34 pairs of twins were measured with dial calipers. In addition, the occlusal morphology of nine pairs of teeth was assessed using a co-ordinate measuring machine with a non-contact laser probe. RESULTS The results showed greater concordance in tooth size for both mesiodistal and bucco-lingual dimensions within twin pairs compared to twin and unrelated controls. Furthermore, monozygotic (MZ) twins showed greater concordance than dizygotic (DZ) twins for all permanent teeth with statistically significant variance for the mesiodistal dimension (P = 0.01) but not bucco-lingual dimension. Superimposed computer models of the digitized occlusal surfaces showed a high degree of similarity for MZ twins compared to DZ twins. The mean intrapair deviation was 147 microm for MZ, 209 microm for DZ and 258 microm for unrelated controls. CONCLUSIONS The remarkable similarity in the tooth size and morphology of monozygotic twins suggests a strong inheritability factor to tooth size and shape and that these may be useful as additional tools for zygosity determination along with other dental traits.
Sleep Architecture Variation in Chronic Tinnitus Patients

Objectives: The aim of the study was to evaluate the sleep architecture and its possible alterations in chronic tinnitus patients, and investigate any possible correlation between sleep architecture modifications and tinnitus perception, adaptation, and the degree of discomfort in these patients. Design: In a prospective, case-control, nonrandomized study, 18 patients affected by chronic tinnitus were compared with a homogeneous control group consisting of 15 healthy subjects. The experimental group was enrolled at the Tinnitus ambulatory at Policlinico Umberto I Department of Sensory Organs, and the control group was composed of voluntary subjects. A full overnight polysomnography was performed on both groups. Tinnitus patients answered two questionnaires: the tinnitus handicap inventory (THI) and a questionnaire concerning their subjective sleep quality, tinnitus intensity before bedtime, tinnitus intensity at remembered nocturnal wake-up periods, and tinnitus intensity at morning wake-up. Controls completed only the sleep quality questionnaire. Results: All tinnitus patients had a statistically significant alteration in sleep stages. Average percentage of stage 1 + stage 2 was 85.4% ± 6.3, whereas, in the control group, the average percentage of stage 1 + stage 2 was 54.9 ± 11.2 (p < 0.001). Stages 3 and 4 and rapid eye movement (REM) sleep was lacking in all tinnitus patients with an average percentage of 6.4 ± 4.9 of REM sleep, and 6.4 ± 4.9 of stages 3 + 4. The control group showed an average percentage of 21.5 ± 3.6 of REM sleep and 21.5 ± 3.6 of stages 3 + 4 (p < 0.001). No correlation was found between the decrease of REM and the increase of the THI score in the tinnitus group (r = 0.04). However, a mild correlation was found between the increase of light sleep (stage 1 + stage 2) and the THI score reported by the tinnitus group. Therefore, patients with light sleep report a higher THI score (r = 0.4). Conclusions: The significant alteration of sleep parameters assessed in tinnitus patients underlines the necessity to consider an adequate therapy that could improve patients’ sleep quality and also opens avenues for further investigations.
Clinical utility of EEG in alcohol‐related seizures

Objective– To study if electroencephalogram (EEG) can discriminate between alcohol‐related seizures (ARS) and seizures unrelated to alcohol use. Material and methods– Alcohol‐related seizures was defined as a seizure in a patient with score ≥ 8 in the Alcohol Use Disorders Identification Test (AUDIT). Twenty‐seven patients with ARS (22 without epilepsy: ARSwE), 21 AUDIT‐negative epileptic patients with seizures (ES), and 30 other AUDIT negative patients with seizures (OS) were studied. Thirty‐seven epilepsy outpatients and 79 sciatica inpatients were controls. Results– Epileptiform and slow activity were less frequent in the ARSwE than in the ES group. Alpha amplitude was lower in the ARSwE than the other groups. Photoparoxysmal activity was not observed. EEG was associated with a larger negative predictive value (78% probability of non‐ARS if EEG was abnormal) than a positive predictive value (55% probability of ARS if EEG was normal). Conclusion– A definitely abnormal EEG suggests epilepsy or symptomatic seizures unrelated to alcohol. The predictive value of a normal EEG is limited, but the typical post‐ictal finding in ARS is nevertheless a normal low‐amplitude EEG record.
Pyroxasulfone resistance in Lolium rigidum conferred by enhanced metabolic capacity

Author Contributions RB and AP designed and performed the experiments. RB, AP, TG, SP wrote the manuscript. One sentence summary This study provides novel insight into herbicide resistance conferred by GST-based detoxification to allow proactive intervention to minimize weed resistance evolution. Abstract The evolution of herbicide-resistant weed populations in response to synthetic herbicide selective pressure is threatening safe weed control practices achieved by these molecules. In Australia multiple-resistant populations of annual ryegrass (Lolium rigidum) are effectively controlled by soil-applied herbicides which provide adequate weed control. In this study we define the mechanistic basis of the experimentally-evolved resistance to the soil-applied herbicide pyroxasulfone in a L. rigidum population. TLC and HPLC-MS provide biochemical confirmation that pyroxasulfone resistance is metabolism-based with identification and quantification of pyroxasulfone metabolites formed via a glutathione conjugation pathway in pyroxasulfone-resistant L. rigidum plants. The observed over-expression of two putative resistance-endowing GST genes is consistent with pyroxasulfone-resistance in parental plants (P6) and positively correlated to pyroxasulfone resistance in F1 pair-cross progenies. Thus, a major detoxification mechanism involves glutathione conjugation to pyroxasulfone and GST over-expression in pyroxasulfone-resistant L. rigidum plants. The definition of the genetic basis of metabolic resistance in weeds can be a first crucial step towards chemical means to reverse resistance and improve long-term weed resistance management.
Dietary Restriction‐Induced Alterations in Bone Phenotype: Effects of Lifelong Versus Short‐Term Caloric Restriction on Femoral and Vertebral Bone in C57BL/6 Mice

Caloric restriction (CR) is a well‐described dietary intervention that delays the onset of aging‐associated biochemical and physiological changes, thereby extending the life span of rodents. The influence of CR on metabolism, strength, and morphology of bone has been controversially discussed in literature. Thus, the present study evaluated whether lifelong CR versus short‐term late‐onset dietary intervention differentially affects the development of senile osteoporosis in C57BL/6 mice. Two different dietary regimens with 40% food restriction were performed: lifelong CR starting in 4‐week‐old mice was maintained for 4, 20, or 74 weeks. In contrast, short‐term late‐onset CR lasting a period of 12 weeks was commenced at 48 or 68 weeks of age. Control mice were fed ad libitum (AL). Bone specimens were assessed using microcomputed tomography (μCT, femur and lumbar vertebral body) and biomechanical testing (femur). Adverse effects of CR, including reduced cortical bone mineral density (Ct.BMD) and thickness (Ct.Th), were detected to some extent in senile mice (68+12w) but in particular in cortical bone of young growing mice (4+4w), associated with reduced femoral failure force (F). However, we observed a profound capacity of bone to compensate these deleterious changes of minor nutrition with increasing age presumably via reorganization of trabecular bone. Especially in lumbar vertebrae, lifelong CR lasting 20 or 74 weeks had beneficial effects on trabecular bone mineral density (Tb.BMD), bone volume fraction (BV/TV), and trabecular number (Tb.N). In parallel, lifelong CR groups showed reduced structure model index values compared to age‐matched controls indicating a transformation of vertebral trabecular bone microarchitecture toward a platelike geometry. This effect was not visible in senile mice after short‐term 12‐week CR. In summary, CR has differential effects on cortical and trabecular bone dependent on bone localization and starting age. Our study underlines that bone compartments possess a lifelong capability to cope with changing nutritional influences. © 2015 American Society for Bone and Mineral Research.
Clumpy photon-dominated regions in Carina - I. [C I] and mid-J CO lines in two 4'$\times$4' fields

Context. The Carina region is an excellent astrophysical laboratory for studying the feedback mechanisms of newly born, very massive stars within their natal giant molecular clouds (GMCs) at only 2.35 kpc distance. Aims. We use a clumpy PDR model to analyse the observed intensities of atomic carbon and CO and to derive the excitation conditions of the gas. Methods. The NANTEN2-4 m submillimeter telescope was used to map the [C i] 3 P1− 3 P0, 3 P2− 3 P1 and CO 4–3, 7–6 lines in two 4 � × 4 � regions of Carina where molecular material interfaces with radiation from the massive star clusters. One region is the northern molecular cloud near the compact OB cluster Tr 14, and the second region is in the molecular cloud south of η Car and Tr 16. These data were combined with 13 CO SEST spectra, HIRES/IRAS 60 µm and 100 µm maps of the FIR continuum, and maps of 8 µm IRAC/Spitzer and MSX emission. Results. We used the HIRES far-infrared dust data to create a map of the FUV field heating the gas. The northern region shows an FUV fi eld of af ew 10 3 in Draine units while the field of the southern region is about a factor 10 weaker. While the IRAC 8 µm emission lights up at the edges of the molecular clouds, CO and also [C i] appear to trace the H2 gas column density. The northern region shows a complex velocity and spatial structure, while the southern region shows an edge-on PDR with a single Gaussian velocity component. We constructed models consisting of an ensemble of small spherically symmetric PDR clumps within the 38 �� beam (0.43 pc), which follow canonical power-law mass and mass-size distributions. We find that an average local clump density of 2 × 10 5 cm −3 is needed to reproduce the observed line emission at two selected interface positions. Conclusions. Stationary, clumpy PDR models reproduce the observed cooling lines of atomic carbon and CO at two positions in the Carina Nebula.
Suppression in retrieval practice, part-set cueing, and negative priming memory: The hydrogen model

A number of phenomena in memory have been explained using appeals to active suppression processes, including retrieval practice, part-set cueing, and the negative priming that is observed with associative interference. However, more formal attempts to capture such processes have been absent. This paper outlines the hydrogen model of memory retrieval, which aims to be a simple model with the modest goal of trying to explore what influence suppression would have on memory retrieval. This model contains a single activation component and a single suppression component in which suppression comes into play only after retrieval interference has been detected. This model was created to explore the plausibility and viability of ideas about the operation of suppression during memory retrieval. For hydrogen, the degree of suppression recruited is proportional to the amount of interference experienced. Overall, the pattern of human data was captured by the suppression model.
Effect of Long-Term Glycemic Control on Cognitive Function

OBJECTIVE To investigate the relationship between recurrent hypoglycemia and cognitive impairment in insulin-dependent diabetic patients. RESEARCH DESIGN AND METHODS Seventy patients who were diagnosed as diabetic at age 18 years or older, were under 55 years old, and had no condition likely to affect cognitive abilities were recruited from a diabetic register. Patients were interviewed to obtain information on the frequency of major and minor hypoglycemia. Their cognitive abilities were assessed on tests of premorbid intelligence, current intelligence, reaction time, concentration, memory, and information processing. RESULTS There was a significant correlation between the apparent decline in intelligence, expressed as the discrepancy between the estimated premorbid and the actual performance intelligence quotient, and the frequency of major hypoglycemic attacks (rs = −0.30; P < 0.01). Comparison of patients with and without recurrent hypoglycemia showed few significant differences in cognitive ability. CONCLUSIONS Results support previous work that suggests that major hypoglycemic attacks have a significant effect on some aspects of cognitive function, but the clinical importance of this finding remains to be determined.
Contributions of Na+/H+ exchanger isoforms to preimplantation development of the mouse

Previous work provided evidence of Na+/H+ exchanger activity in the apical domain of mouse trophectodermal plasma membranes that provides a route for entry of extracellular Na+ (Manejwala et al., 1989). This activity was hypothesized to contribute to the trans‐trophectodermal Na+ flux that is required for blastocoel expansion. In the present work, we have used reverse transcriptase‐polymerase chain reaction (RT‐PCR) and immunocytochemistry to identify members of the Na+/H+ exchanger (NHE) family that are likely to participate in this process. When cDNA preparations from ovulated oocytes and several stages of preimplantation development were tested with PCR primers specific for the NHE‐1, ‐2, ‐3, and ‐4 isoforms of the exchanger, only amplicons representing the NHE‐1 and NHE‐3 isoforms were detected. The identity of these amplicons was confirmed by direct sequencing. NHE‐1 mRNA is present in oocytes and in all preimplantation stages, increasing threefold on a per embryo basis between the 4‐cell and blastocyst stages. NHE‐3 mRNA, on the other hand, was only detected in oocytes. Immunocytochemical analysis of blastocysts revealed that NHE‐1 is localized in the basolateral domain of the trophectoderm, whereas NHE‐3 is localized in the apical domain, a situation like that in epithelia of adult organs. We conclude that NHE‐3, an oogenetic product that persists into the blastocyst stage, is the Na+/H+ exchanger isoform most likely to be involved in blastocoel expansion. Mol. Reprod. Dev. 50:146–153, 1998. © 1998 Wiley‐Liss, Inc.
Destruction of Crystallographic Texture in Zirconium Alloy Tubes

The paper investigates the dependence of the transformation texture of Zr-2.5wt%Nb tubes and rods on the initial texture, the method of heating (furnacing, conductive heating, inductive heating) and cooling (furnace cooling, water quenching, water shower), stress, and thermal cycling. It was demonstrated that the primary factors determining the transformation texture are the initial texture and the heating rate for quenching. From the investigation results, a method of final thermal treatment of finished zirconium reactor core components (pressure tubes, guide tubes, and cladding fuel rods) is suggested, allowing the destruction of their texture without changing the well-established manufacturing process. The suggested SHF heating includes the use of the α→β→α transformation with fast heating up to the β-phase, subsequent quenching for texture destruction, and annealing for transformation from the metastable α'-state to the equilibrium double-phase αZr + βNb state.
The comparison of family function based on the McMaster model in fertile and infertile women

Introduction: One of the main parts of the lives of infertile impaired is social relationships and their family functions. This study aimed to compare the family function based on the McMaster model in fertile and infertile women. Materials and Methods: This research is a similar one. The population consisted of all infertile women referred to the two infertility centers and fertile females related to health areas located in the same area in Tehran. The sampling method was the convenience one and in both groups, 50 women were recruited as samples and they responded to the demographic and Family Assessment Device (FAD) questionnaires. The obtained information was investigated by using inferential and descriptive statistics and SPSS 22 software. Findings: The results showed the following behavioral control variables (p = 0/ 003), roles (p = 0/ 002), emotional responsiveness (p = 0/ 020) and emotional involvement (p = 0/ 006). There was a clear distinction between fertile and infertile women and infertile women obtained worse scores. Conclusion: The results indicated that infertile women have crucial problems in family functioning that can have an impact on other aspects of life and their health.
C-Reactive Protein as a Prognostic Factor for Human Osteosarcoma: A Meta-Analysis and Literature Review

Background Osteosarcoma is the most common primary bone cancer in growing adolescents and young adults. The prognostic role of C-reactive protein (CRP) in patients with osteosarcoma is not fully investigated. The purpose of this study is to perform a meta-analysis and literature review on the role of CRP in osteosarcoma and to assess the potential role of serum CRP as a prognostic factor for patients with osteosarcoma. Methods A detailed literature search was made in Medline for related research publications written in English. Methodological quality of the studies was also evaluated. The data were extracted and assessed by two reviewers independently. Analysis of pooled data were performed, risk ratio (RR) and corresponding confidence intervals (CIs) were calculated and summarized respectively. Results Final analysis of 397 patients from 2 eligible studies was performed. Combined RR of CRP expression suggested that the raised serum CRP level had an adverse prognostic effect on overall survival of patients with osteosarcoma (n = 397 in 2 studies; RR = 0.35; 95% CI: 0.18–0.68; p = 0.002). In the uni- and multivariate survival analysis, response rate and CRP levels were the only independent prognostic variables. Conclusions The results of this meta-analysis suggest that CRP expression confers a worse prognosis in patients with osteosarcoma. Large prospective studies are necessary to provide solid data to confirm the prognostic significance of CRP.
Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells.

The purpose of these studies was to determine whether systemic administration of recombinant interleukin 12 (rIL-12) is able to potentiate an initial, but insufficient T-cell antitumor response. Mice challenged with carcinoma cells engineered to release interleukin 2 (IL-2) and displaying such a response received single or multiple i.p. injections of rIL-12. This combination of systemic rIL-12 and local IL-2 increased the percentage of mice that rejected two different IL-2 gene-transduced tumors. In another set of experiments more closely resembling a clinical situation, IL-2 gene-transduced tumors were used as vaccines in an attempt to cure mice bearing wild-type parental tumors. The combination of these vaccines with systemic rIL-12 cured mice more effectively than rIL-12 and IL-2 gene-transduced tumor vaccines alone.