Miracle-dz/UniFAR-FTUs huggingface dataset:
Altered phenotypic and functional characteristics of CD3+CD56+ NKT-like cells in human gastric cancer

CD3+CD56+ natural killer T (NKT)-like cells are a group of CD3+ T cells sharing characteristics of NK and T cells and constitute a major component of host anti-tumor immune response in human cancer. However, the nature, function and clinical relevance of CD3+CD56+ NKT-like cells in human gastric cancer (GC) remain unclear. In this study, we showed that the frequencies of CD3+CD56+NKT-like cells in GC tumors were significantly decreased and low levels of tumor-infiltrating CD3+CD56+ NKT-like cells were positively correlated with poor survival and disease progression. Most CD3+CD56+NKT-like cells in GC tumors were CD45RA−CD27+/− central/effector-memory cells with decreased activity and lower expression levels of CD69, NKG2D and DNAM-1 than those in non-tumor tissues. We further observed that tumor-infiltrating CD3+CD56+ NKT-like cells had impaired effector function as shown by decreased IFN-γ, TNF-α, granzyme B and Ki-67 expression. Moreover, in vitro studies showed that soluble factors released from GC tumors could induce the functional impairment of CD3+CD56+ NKT-like cells. Collectively, our data indicate that decreased tumor-infiltrating CD3+CD56+ NKT-like cells with impaired effector function are associated with tumor progression and poor survival of GC patients, which may contribute to immune escape of GC.
Methodology for Determining the Impact of Highway Bypasses in Oklahoma

Project No. 2150 develops a methodology for determining the impact of highway bypasses on small town business districts in Oklahoma. The focus is predicting likely impacts of proposed bypasses on US 70. Economic impacts are measured by comparing changes in the sales tax base in the bypassed cities with those of in similar non-bypassed cities. Quasi-experimental control group and difference-in-difference estimation techniques are employed. The method is demonstrated by analyzing the 1993 bypass of Stonewall as well as bypasses of Rush Springs and Snyder in the early 1970s. The null hypothesis that the bypasses had no impact on city sales taxes cannot be rejected. The results are not conclusive due to a lack of bypass cases and usable data on traffic volumes and composition, residential property values, regional economic performance and business climate during the pre-bypass period. The recommendation based on site visits and interviews are to include signs identifying business districts as well as follow-up safety studies of route intersections in bypass project plans.
On the capability of finite groups of class two and prime exponent

We consider the capability of $p$-groups of class two and odd prime exponent. The question of capability is shown to be equivalent to a statement about vector spaces and linear transformations, and using the equivalence we give proofs of some old results and several new ones. In particular, we establish a number of new necessary and new sufficient conditions for capability, including a sufficient condition based only on the ranks of $G/Z(G)$ and $[G,G]$. Finally, we characterise the capable groups among the 5-generated groups in this class.
Barriers in the help-seeking process: A multiple-case study of early-onset dysthymia in Sweden

The aim of this study was to investigate barriers to diagnosis and adequate treatment of patients with early-onset dysthymia by studying how understandings of illness by patients and providers have evolved and how treatments have been negotiated over time. A theory-testing and explorative multiple-case study design was used with developmental cognitive theory as framework. Data pertaining 10 non-remission dysthymic patients were analyzed using five sources: 1) case records, 2) interviews, 3) self-report questionnaires, 4) observations, and 5) life-charting, eliciting life events, course and treatments. The analysis comprised qualitative content analysis and a coding scheme of knowledge structures. Barriers could be explained by misunderstandings as patients mainly expressed illness in concrete, perceptually bound knowledge structures and providers focused on one aspect, instead of on the complexity of concurrent aspects. Another barrier, associated to comorbid personality disorder, was a core pattern of concealing due to fear of rejection and mistrust. Other barriers were connected to providers’ attitudes and contextual factors such as access problems and lack of follow-up. A theoretical model that involves patients’ understanding of illness in preoperational thinking and providers’ cognitive errors can explain communication barriers. Means of shared understanding and treatment planning are suggested. Future treatment research could elucidate the impact of the core belief of rejection with associated strategy of concealing by assessing these variables as predictors and as targets for change.
Examining the structure of eating pathology through scale construction

Eating disorders are alarmingly prevalent and potentially lethal. The proper assessment of eating disorder symptoms is therefore crucial for the early identification and treatment of those suffering from these serious illnesses. Current measures of eating disorder symptoms are either very narrow in scope (e.g., assess only one aspect of disordered eating, such as bingeing) and/or have one or more serious limitations, such as inconsistent factor structures and/or poor discriminant validity. Because several of the existing measures of eating disorders were created over 20 years ago, many of these limitations are the direct result of out-dated scale development methods and testing. The goal of this study was to determine the structure underlying the symptoms of eating disorders and develop a multidimensional measure of eating pathology based on this structure. To accomplish this goal, an initial item pool was developed to assess 20 dimensions of eating pathology. The initial item pool of 160 items was administered to a student sample (N=433) and community sample (N=407) to determine the preliminary structure of the measure using exploratory and confirmatory factor analyses. The revised measure was then administered to independent samples of psychiatric patients (N=190) and students (N=227). Exploratory and confirmatory factor analyses revealed a 7-factor structure that showed excellent convergent and discriminant validity. The final measure was also internally consistent (median coefficient alphas ranged from .84-.89) and reliable over a twoto four-week period (r‘s ranged from .70-.84). The current study represents one of, perhaps, the most comprehensive scale development project ever conducted in the field of eating disorders and is expected to improve future basic and treatment research focused on eating disorders.
Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear

Synapsin III is a neuron‐specific phosphoprotein that plays an important role in synaptic transmission and neural development. While synapsin III is abundant in embryonic brain, expression of the protein in adults is reduced and limited primarily to the hippocampus, olfactory bulb and cerebral cortex. Given the specificity of synapsin III to these brain areas and because it plays a role in neurogenesis in the dentate gyrus, we investigated whether it may affect learning and memory processes in mice. To address this point, synapsin III knockout mice were examined in a general behavioral screen, several tests to assess learning and memory function, and conditioned fear. Mutant animals displayed no anomalies in sensory and motor function or in anxiety‐ and depressive‐like behaviors. Although mutants showed minor alterations in the Morris water maze, they were deficient in object recognition 24 h and 10 days after training and in social transmission of food preference at 20 min and 24 h. In addition, mutants displayed abnormal responses in contextual and cued fear conditioning when tested 1 or 24 h after conditioning. The synapsin III knockout mice also showed aberrant responses in fear‐potentiated startle. As synapsin III protein is decreased in schizophrenic brain and because the mutant mice do not harbor obvious anatomical deficits or neurological disorders, these mutants may represent a unique neurodevelopmental model for dissecting the molecular pathways that are related to certain aspects of schizophrenia and related disorders.
Personality Traits and Burnout Among Athletic Trainers Employed in the Collegiate Setting.

CONTEXT Burnout, a psychological state of mental weariness that occurs when work stresses become overwhelming, has frequently been documented in athletic trainers and has been hypothesized to affect professional retention. Experiences of burnout may be influenced by individual-level factors such as gender or personality, though few researchers have investigated such interactions in athletic trainers. OBJECTIVE To investigate the relationship between personalities, as measured by the Big Five Personality Inventory, and burnout. DESIGN Cross-sectional study. SETTING Online Web-based survey. PATIENTS OR OTHER PARTICIPANTS A total of 189 athletic trainers working in the collegiate setting, 65 men (34.4%) and 124 women (65.6%), with an average of 5 ± 3 years certified and 2.5 ± 2 years working in their current position. MAIN OUTCOME MEASURE(S) Data were collected using a Web-based survey instrument consisting of 3 sections: (1) demographics, (2) burnout survey, and (3) Big Five Personality Inventory. Likert responses for the burnout score were summed. Independent t tests, Pearson correlations, and multiple regressions were calculated to evaluate the relationships between demographics and burnout and between burnout and personality. RESULTS This group of athletic trainers experienced moderate burnout, regardless of gender. A weak negative correlation was present between burnout score and both agreeableness and extraversion. A weak positive correlation existed between burnout and neuroticism. These variables did not predict burnout scores; only neuroticism added significantly to the weak predictive value. Personality explained only 17.3% of the variability in burnout scores. CONCLUSIONS Our study confirms the findings of previous researchers highlighting moderate burnout in athletic trainers employed in the collegiate setting. We did not find that personality significantly predicted burnout, though it did account for a small amount of the variance in burnout scores. Thus, organizational-level factors may play a greater role in determining burnout in athletic trainers than individual-level factors such as personality.
Integration versus separation in Stroop‐like counting interference tasks1

Two versions of a Stroop-like counting interference task were compared to examine how irrelevant information is ignored. In the integrated task, participants enumer- ated digits (inconsistent condition) or letters (neutral condition) while attempting to ignore the identity of the characters. In the newly created separated task, participants enumerated asterisks while attempting to ignore a single digit (inconsistent condition) or letter (neutral condition) at fixation. Interference (longer responses in the inconsistent condition than in the neutral condition) was small but significant in both tasks but was not reduced by separation. Contrasted with the pattern in the color-word Stroop task, these results sug- gest that dimensional separation has different effects on interference depending on the overall amount of interference.
Similarity and Rules United: Similarity- and Rule-Based Processing in a Single Neural Network

A central controversy in cognitive science concerns the roles of rules versus similarity. To gain some leverage on this problem, we propose that rule- versus similarity-based processes can be characterized as extremes in a multidimensional space that is composed of at least two dimensions: the number of features (Pothos, 2005) and the physical presence of features. The transition of similarity- to rule-based processing is conceptualized as a transition in this space. To illustrate this, we show how a neural network model uses input features (and in this sense produces similarity-based responses) when it has a low learning rate or in the early phases of training, but it switches to using self-generated, more abstract features (and in this sense produces rule-based responses) when it has a higher learning rate or is in the later phases of training. Relations with categorization and the psychology of learning are pointed out.
AN EVALUATION OF CHANGES AND RECOVERY IN THE OLFACTORY EPITHELIUM IN MICE AFTER INHALATION EXPOSURE TO METHYLETHYLKETOXIME

Methylethylketoxime, also known as MEKO or 2-butanone oxime (CAS No. 96-29-7), is a clear, colorless to light yellow liquid at room temperature. It is an industrial antioxidant used as an antiskinning agent in alkyd paint, an industrial blocking agent for urethane polymers, and a corrosion inhibitor in industrial boilers, and can be found in some adhesives and silicone caulking products. Male CD-1 mice were exposed 6 h/day, 5 days/wk, for 1, 2, 4, or 13 wk via whole-body inhalation exposures to MEKO vapor concentrations of 0, 3 ± 0.1, 10 ± 0.3, 30 ± 1, or 100 ± 2 ppm (10 mice/group/interval). Satellite animals were removed after 1, 2, 4, or 13 wk of exposure and allowed to recover for 4 or 13 wk (5 mice/group/interval). After termination, the nasal turbinates were evaluated microscopically, and cross-sectional nasal maps of the lesions were prepared. At the end of the 1-, 2-, 4-, and 13-wk exposure periods, degeneration of the olfactory epithelium lining the dorsal meatus was seen in the anterior region of the nasal cavity. In a few instances, the olfactory epithelium covering the tips of the nasoturbinal scrolls projecting into the dorsal region of the nasal cavity was also degenerated. Large areas of olfactory epithelium lying laterally and posteriorly were unaffected. In general, approximately 10% or less of the total olfactory tissue was affected. In several instances, the degenerated olfactory epithelium was reepithelialized by squamous/squamoid and/or respiratory types of epithelium. Degeneration, which was dose related in incidence and severity, was seen in mice exposed to 30 and 100 ppm after 1 wk of exposure and in several mice exposed to 10 ppm after 13 wk of exposure. The incidence and severity of the degeneration present after 1 wk of exposure did not increase with the longer exposures. The olfactory degeneration was reversible. Recovery was complete within 4 wk following exposures at 10 ppm and nearly complete within 13 wk after exposures at 30 and 100 ppm. A no-observed-effect level (NOEL) for the olfactory degeneration was considered to be 3 ppm.
The Working Group on Blood Pressure Monitoring of the European Society of Hypertension.

In the first paper the demise of the mercury sphygmomanometer is examined. After a little more than a century of use, the conventional Riva-Rocci/Korotkoff technique of measuring blood pressure with a mercury sphygmomanometer, and stethoscope is now being relegated to the museum shelves. Our reliance on what has been an inaccurate technique is questioned and we are urged to accept that the age of technology offers more accurate alternative methodologies. However, we must ensure that the automated devices that are replacing the conventional technique are validated independently for accuracy. The Working Group on Blood Pressure Monitoring of the European Society of Hypertension has recently published an International Protocol to facilitate the validation of more automated devices than was possible with the earlier more complicated protocols.
Uncertainties in counterfactuals : the determinants and emotional consequences of counterfactual probability judgments

Counterfactual representations refer to people’s imaginations about the alternative possibilities to the actual world (i.e., what might have been). The present thesis embraces the notion that the psychological impacts of those representations are dictated by the degree of certainty or uncertainty people assign to them, namely, their counterfactual probability judgments (i.e., “How likely could things have been different? ”). The thesis reports six experiments investigating the determinants as well as the emotional consequences of counterfactual probability judgments. Experiments 1, 2 and 3 found that both people’s conditional and unconditional counterfactual probability judgments were heightened when a past outcome was physically or numerically proximate to its alternative. Experiments 4 and 5 found that people’s counterfactual probability judgments were not only affected by the static proximity cue but also by its dynamic variations. When outcome proximity was equal, the shrinking physical distance towards a counterfactual outcome heightened one’s subjective likelihood of that outcome, compared to if the distance stayed constant. Experiment 6 found that the effect of “shrinking distance” could manifest itself as an antecedent temporal order effect on people’s counterfactual probability judgments. That is, a counterfactual outcome was deemed more likely if the factual outcome was preceded by a decisive event that occurred latter in the causal sequence rather than earlier. These results are broadly consistent with the theory of the simulation heuristic which posits that subjective probabilities are estimated by assessing the ease with which a relevant scenario can be mentally constructed. The emotional consequences of counterfactual probability judgments were investigated within the theoretical framework of the Reflective and Evaluative Model of Comparative Thinking (REM). The evidence from Experiments 2, 3, 4 and 5 suggests that the effect of counterfactual probability judgments on emotions are contingent on people’s temporal perspective – affective assimilation will be enhanced when future possibility is present (i.e., the outcome is indecisive or changeable) which encourages a reflective simulation while affective contrast will be enhanced when future possibility is absent (i.e., the outcome is decisive or unchangeable) which encourages an evaluative simulation. These findings suggest that the psychological impact of counterfactual thinking should be discussed in terms of a three-way interaction between its direction (upward or downward), probability (low or high), and simulation mode (reflection or evaluation).
Syllable Weight: Phonetic Duration and Phonemic Contrast*

Ahn, Mee-Jin. (2003). Syllable weight: phonetic duration and phonemic contrast. Language Research 39(2), 355-381. This paper addresses two questions: why, in quantity-sensitive systems, do evv and eve syllables constitute better stress targets than ev syllables, and why does the weight of eve syllables vary? I argue that evv syllables are optimal stress targets because their long vowel duration allows for the best expression of the phonetic correlates of stress. Although eve syllables appear to attract stress in some languages, this attraction should be understood as a consequence of stress repulsion from ev syllables. The stress attraction of eve syllables occurs only where ev syllabYes are subject to positional vowel lengthening and stress-induced lengthenfng. In this position, ev syllables repel stress to preserve the phonemic contrast of vowel length. eve syllables are protected from extreme vowel lengthening in the same positions due to closed syllable shortening. I present exper­ imental evidence from Jordanian Arabic where only evv and eve sylla­ bles attract stress in penultimate position, to support my claim that \'owel lengthening effects in penultimate ev syllables are extreme. As' a result, ev syllables avoid stress to maintain their phonemic vowel length and eve and evv syllables receive stress in the target position. I conclude that eve syllables are not inherent stress attractors at all.
Characterization of Changes to the Cell Surface during the Life Cycle of Streptomyces coelicolor: Atomic Force Microscopy of Living Cells

ABSTRACT Cell surface changes that accompany the complex life cycle of Streptomyces coelicolor were monitored by atomic force microscopy (AFM) of living cells. Images were obtained using tapping mode to reveal that young, branching vegetative hyphae have a relatively smooth surface and are attached to an inert silica surface by means of a secreted extracellular matrix. Older hyphae, representing a transition between substrate and aerial growth, are sparsely decorated with fibers. Previously, a well-organized stable mosaic of fibers, called the rodlet layer, coating the surface of spores has been observed using electron microscopy. AFM revealed that aerial hyphae, prior to sporulation, possess a relatively unstable dense heterogeneous fibrous layer. Material from this layer is shed as the hyphae mature, revealing a more tightly organized fibrous mosaic layer typical of spores. The aerial hyphae are also characterized by the absence of the secreted extracellular matrix. The formation of sporulation septa is accompanied by modification to the surface layer, which undergoes localized temporary disruption at the sites of cell division. The characteristics of the hyphal surfaces of mutants show how various chaplin and rodlin proteins contribute to the formation of fibrous layers of differing stabilities. Finally, older spores with a compact rodlet layer develop surface concavities that are attributed to a reduction of intracellular turgor pressure as metabolic activity slows.
Structure/Psychophysical Relationships in X-Linked Retinoschisis

Purpose To compare structural properties from spectral-domain optical coherence tomography (SDOCT) and psychophysical measures from a subset of patients enrolled in a larger multicenter natural history study of X-linked retinoschisis (XLRS). Methods A subset of males (n = 24) participating in a larger natural history study of XLRS underwent high-resolution SDOCT. Total retina (TR) thickness and outer segment (OS) thickness were measured manually. Shape discrimination hyperacuity (SDH) and contour integration perimetry (CIP) were performed on an iPad with the myVisionTrack application. Sensitivity was measured with fundus-guided perimetry (4-2 threshold testing strategy; 10-2 grid, spot size 3, 68 points). Correlation was determined with Pearson's r correlation. Values are presented as the mean ± SD. Results Mean macular OS thickness was less in XLRS patients (17.2 ± 8.1 μm) than in controls (37.1 ± 5.7 μm; P < 0.0001) but mean TR thickness was comparable (P = 0.5884). For patients, total sensitivity was lower (13.2 ± 6.6 dB) than for controls (24.2 ± 2.4 dB; P = 0.0008) and had a strong correlation with photoreceptor OS (R2 = 0.55, P = 0.0001) and a weak correlation with TR thickness (R2 = 0.22, P = 0.0158). The XLRS subjects had a logMAR best corrected visual acuity (BCVA) of 0.5 ± 0.3 that was associated with OS (R2 = 0.79, P < 0.0001) but not TR thickness (R2 = 0.01, P = 0.6166). Shape DH and CIP inner ring correlated with OS (R2 = 0.33, P = 0.0085 and R2 = 0.47, P = 0.0001, respectively) but not TR thickness (R2 = 0.0004, P = 0.93; R2 = 0.0043, P = 0.75, respectively). Conclusions When considered from a single visit, OS thickness within the macula is more closely associated with macular function than TR thickness within the macula in patients with XLRS.