Miracle-dz/UniFAR-FTUs huggingface dataset:
3D CBCT morphometric assessment of mental foramen in Arabic population and global comparison: imperative for invasive and non-invasive procedures in mandible

Abstract Background: Recent advancements in clinical dentistry have increased the possibilities of surgical procedures in the mental region. A detailed knowledge of mental foramen (MF) morphometry is significant to preserve integrity of the mental nerve trunk in surgical interventions such as orthognathic surgery, implant placement and anaesthetic block. Objective: The aim of this study was to determine the most accurate position of the mental foramen by using new assessment approach in a sample of dental patients presenting to the specialist dental clinic, College of Dentistry, Al Jouf University, Saudi Arabia. Study design: A retrospective study was performed using cone beam computed tomography (CBCT) of 600 patients (40.1 ± 11.78 years old). Following inclusion and exclusion criteria, 395 CBCT were finally obtained and analyzed for the most accurate position of the mental foramen (MF) by OnDemand 3D software (Seoul, Korea). Prevalence of shape of MF and accessory MF were also assessed. Pearson chi-square test was employed to test significant differences between genders and races. Results: The most common horizontal and vertical position of the mental foramen was in line with the long axis of 2nd premolar (41.3%) and below the root apex level (93.2%), respectively. The most common shape of MF was round type (72.66%). The prevalence of accessory 2MF and 3MF was 2.28% and 0.25%, respectively. Conclusion: New information about MF presented in this article can help anatomists, prosthodontists, orthodontists, surgeons, forensic odontologists and paleoanthropologists to predict the position of the MF and perform safer surgeries.
Validation of Automatically Classified Magnetic Resonance Images for Carotid Plaque Compositional Analysis

Background and Purpose— MRI may be used for noninvasive assessment of atherosclerotic lesions; however, MRI evaluation of plaque composition requires validation against an accepted reference standard, such as the American Heart Association (AHA) lesion grade, defined by histopathological examination. Methods— Forty-eight carotid endarterectomy specimen cross-sections had AHA lesion grade determined histopathologically and were concurrently imaged using combinations of 8 MRI contrast weightings in vitro. A maximum likelihood classification algorithm generated MRI “maps” of plaque components, and an AHA lesion grade was assigned correspondingly. Additional analyses compared classification accuracy obtained with a commonly used set of magnetic resonance contrast weightings [proton density (PDw), T1 (T1w), and partial T2 (T2w)] to accuracy obtained with the combination of PDw, T1w, and diffusion-weighted (Dw) contrast. Results— For the 8-contrast combination, the sensitivities for fibrous tissue, necrotic core, calcification, and hemorrhage detection were 83%, 67%, 86%, and 77%, respectively. The corresponding specificities were 81%, 78%, 99%, and 97%. Good agreement (79%) between magnetic resonance and histopathology for AHA classification was achieved. For the PDw, T1w, and Dw combination, the overall classification accuracy was insignificantly different at 78%, whereas the overall classification accuracy using PDw, T1w, and partial T2w contrast weightings was significantly lower at 67%. Conclusions— This study provides proof-of-principle that the composition of atherosclerotic plaques determined by automated classification of high-resolution ex vivo MRI accurately reflects lesion composition defined by histopathological examination.
Students' motivations and their contributions to virtual learning

In recent years, increasing attention has been devoted to virtual learning. Individual characteristics are known to play a crucial role in learning processes but only limited research has been conducted in the context of virtual settings. Therefore, we used an integrated multimethod approach in order to examine the impact of types of academic motivation (intrinsic vs. extrinsic) on virtual learning. This study of 100 online summer course participants indicates that the willingness to contribute to discourse depends on the type of motivation. Intrinsically motivated learners became central and prominent contributors to cognitive discourse. In contrast, extrinsically motivated learners contributed less and were positioned on the outer fringe of the social network.
Deleterious Impact of Mismatching for Human Leukocyte Antigen-C in Presensitized Recipients of Kidney Transplants

Background. Allocation of deceased donor kidneys is commonly based on matching for human leukocyte antigen (HLA)-A, -B, and -DR, whereas HLA-C is currently disregarded. We investigated the influence of HLA-C compatibility on renal allograft survival. In addition, we tested an approach of matching for HLA-C epitopes. Methods. A cohort of 2260 deceased donor kidney transplants were typed for HLA-C using polymerase chain reaction-sequence specific primer method. Samples for DNA typing, serum results on presensitization (lymphocytotoxicity), and clinical data were provided by transplant centers participating in the Collaborative Transplant Study. Results. HLA-C mismatch was found to be associated with significantly decreased graft survival in presensitized (P<0.001) but not in non-presensitized (P=0.75) recipients. Mismatch of certain HLA-C epitopes seemed to be more influential than others, with mismatches showing a negative impact on graft survival in presensitized patients. Conclusions. HLA-C mismatch has a substantial deleterious effect on graft survival in presensitized kidney recipients. Our study points out the need for investigations directed at identifying donor-specific HLA-C antibodies and evaluating their relevance in transplantation. In view of the fact that current assays for determining HLA-C specific antibodies are hampered by additional detection of clinically irrelevant antibodies, matching for HLA-C may provide a reasonable approach to improve transplant outcomes in presensitized kidney transplant recipients.
Pretreatment optimization methods for increased sugar yields from biomass pyrolysis

In the search for a renewable energy source that could replace petroleum and other nonrenewable energy sources, pyrolysis of biomass is a hopeful alternative and pretreatment could further improve its potential. There are several possible routes for pretreating lignocellulosic biomass, but many need further refining before becoming economical. The main obstacle for the conversion of biomass to high quality products is the presence of alkali and alkaline earth metals (AAEMs) that are known to impair cellulose decomposition to levoglucosan and promote char, water, and light oxygenate formation. One pretreatment option is to remove the AAEMs from the biomass by washing. Another efficient process of converting biomass into high quality bio-oil is a dilute acid pretreatment that passivates AAEMs in biomass, leading to decreased cellulose monomer fragmentation and thus increasing sugar yields. In this study the effectiveness of a washing method--involving a recycled carboxylic acid rich, aqueous fraction of bio-oil--is looked at for red oak. This study also presents an optimization of three important variables in the dilute acid pretreatment process of the agricultural byproduct, cornstover, to increase the value of the bio-oil produced. In the preliminary study, red oak was washed with an aqueous fraction of bio-oil to remove the AAEMs. While effective at removing AAEMs, the levoglucosan yield did not improve, unless a water rinse was incorporated--increasing levoglucosan yields from 3.3 to 13.3 wt%. Passivating the remaining AAEMs in the washed samples with sulfuric acid was less effective but increased levoglucosan yields from 3.3 wt% to 9.8 wt%. These processes were compared to samples that were only passivated with sulfuric acid, which led to levoglucosan yields of 20.8 wt%.
Adverse events and treatment interruption in tuberculosis patients with and without HIV co-infection

Background: Serious treatment associated adverse events are thought to occur more frequently in individuals with tuberculosis (TB) who are co-infected with HIV. A study was undertaken to assess the frequency of serious (grade III/IV) adverse events and interruption of anti-TB treatment in the era of effective antiretroviral therapy. Methods: The incidence of serious adverse events was retrospectively compared in 312 individuals treated for TB, 156 of whom were co-infected with HIV. Results: 111 HIV infected individuals (71%) received highly active antiretroviral therapy at the same time as anti-TB treatment. Serious adverse events were recorded in 40% HIV infected and 26% HIV uninfected individuals (p = 0.008). Peripheral neuropathy and persistent vomiting were more common in co-infected patients (p<0.001; p = 0.006), although all cause interruption of anti-TB treatment occurred with similar frequency in the two groups (13% in HIV infected patients and 15% in HIV uninfected patients; p = 0.74). In 85% of HIV infected patients and 87% of HIV uninfected individuals this was due to hepatotoxicity, which typically presented within 2 months of starting treatment. The median delay in restarting treatment was 4 weeks, so most individuals required full TB re-treatment. Conclusion: Despite a greater rate of serious (grade III/IV) adverse events among HIV infected individuals, discontinuation of anti-TB treatment occurred with a similar frequency in HIV infected and HIV uninfected individuals.
Effects of work-related stress on work ability index among refinery workers

Introduction: Work-related stress is one of the basic problems in industrial also top 10 work-related health problems and it is increasingly implicated in the development a number of problems such as cardiovascular disease, musculoskeletal diseases, early retirement to employees. On the other hand, early retirement to employees from the workplace has increased on the problems of today's industries. Hereof, improving work ability is one of the most effective ways to enhance the ability and preventing disability and early retirement. The aim of This study is determine the relationship between job stress score and work ability index (WAI) at the refinery workers. Materials and Methods: This is a cross-sectional study in which 171 workers from a refinery in isfahan in 2012 who were working in different occupational groups participated. Based on appropriate assignment sampling, 33 office workers, 69 operational workers, and 69 maintenance workers, respectively, were invited to participate in this study. Two questionnaires including work related-stress and WAI were filled in. Finally, the information was analyzed using the SPSS-20 and statistic tests namely, analysis of covariance Kruskal-Wallis test. Pearson correlation coefficient, ANOVA and t-test. Results: Data analysis revealed that 86% and 14% of participants had moderate and severe stress respectively. Average score of stress and standard deviation was 158.7 ± 17.3 that was in extreme stress range. Average score and standard deviation of WAI questionnaire were 37.18 and 3.86 respectively. That placed in a good range. Pearson correlation coefficient showed that WAI score had significant reversed relationship with a score of stress. Conclusion: According to the results, mean stress score among refinery worker was high and one fator that affect work abiity was high stress, hence training on communication skills and safe working environment in order to decreses stress, enhance the work ability of workers.
A foraging advantage for dichromatic marmosets (Callithrix geoffroyi) at low light intensity

Most New World monkey species have both dichromatic and trichromatic individuals present in the same population. The selective forces acting to maintain the variation are hotly debated and are relevant to the evolution of the ‘routine’ trichromatic colour vision found in catarrhine primates. While trichromats have a foraging advantage for red food compared with dichromats, visual tasks which dichromats perform better have received less attention. Here we examine the effects of light intensity on foraging success among marmosets. We find that dichromats outperform trichomats when foraging in shade, but not in sun. The simplest explanation is that dichromats pay more attention to achromatic cues than trichromats. However, dichromats did not show a preference for foraging in shade compared with trichromats. Our results reveal several interesting parallels with a recent study in capuchin monkeys (Cebus capucinus), and suggest that dichromat advantage for certain tasks contributes to maintenance of the colour vision polymorphism.
The implementation of LIFS in a single channel MAC protocol

The combination of RTS/CTS and EIFS enhancements has not adequately addressed the hidden terminal problem (HTP) in the receiver neighbourhood. The EIFS scheme protects ACK packets, while DATA packets are not shielded as the EIFS expires before they are delivered. Our proposed scheme is designed to address the shortcomings of the EIFS in protecting data packets. We propose a scheme which implements a Long Inter-Frame Space (LIFS) which protects DATA packets and calms HTPs within the receiver's carrier sensing range. The performance of the scheme was evaluated through NS 2 simulations. The simulation results show an improvement in network performance. The scheme reduces end to end delay in all the tagged flows.
Likelihood Models for Clustered Binary and Continuous Out comes: Application to Developmental Toxicology

Summary. In developmental toxicology, methods based on dose‐response modeling and quantitative risk assessment are being actively pursued. Among live fetuses, the presence of malformations and reduction in fetal weight are of primary interest, but ordinarily, the dose‐response relationships are characterized in each of the outcomes separately while appropriately accounting for clustering within litters. Jointly modeling the outcomes, allowing different relationships with dose while incorporating the correlation between the fetuses and the outcomes, may be more appropriate. We propose a likelihood‐based model that is an extension of a correlated probit model to incorporate continuous outcomes. Our model maintains a marginal dose–response interpretation for the individual outcomes while taking into account both the correlations between outcomes on an individual fetus and those due to clustering. The joint risk of malformation and low birth weight can then be estimated directly. This approach is particularly well suited to estimating safe dose levels as part of quantitative risk assessment.
Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

Thrombospondin-1 (TSP1) is a large modular matrix protein containing three identical disulfide-linked 180-kD chains that inhibits neovascularization in vivo (Good et al., 1990). To determine which of the structural motifs present in the 180-kD TSP1 polypeptide mediate the anti-angiogenic activity, a series of protease-generated fragments were tested using several in vitro and in vivo assays that reflect angiogenic activity. The majority of the anti-angiogenic activity of TSP1 resides in the central 70-kD stalk region which alone could block neovascularization induced by bFGF in the rat cornea in vivo and inhibit both migration in a modified Boyden chamber and [3H]thymidine incorporation stimulated by bFGF in cultured capillary endothelial cells. Although TSP1 has been shown to bind active TGF beta 1, this cytokine could not account for the inhibitory effects of the stalk region of TSP1 on cultured endothelial cells. Peptides and truncated molecules were used to further localize inhibitory activity to two domains of the central stalk, the procollagen homology region and the properdin-like type 1 repeats. Trimeric recombinant TSP1 containing NH2- terminal sequences truncated after the procollagen-like module inhibited endothelial cell migration in vitro and corneal neovascularization in vivo whereas trimeric molecules truncated before this domain were inactive as was the NH2-terminal heparin-binding domain that is present in both recombinant molecules. A series of peptides from the procollagen-like region, the smallest of which consisted of residues 303-309 of TSP1, inhibited angiogenesis in vivo in the rat cornea and the migration of endothelial cells in vitro. A 19- residue peptide containing these sequences blocked vessel formation in the granulation tissue invading a polyvinyl sponge implanted into the mouse. Nineteen residue peptides derived from two of the three type 1 repeats present in the intact TSP1 molecule blocked neovascularization in vivo in the rat cornea and inhibited the migration of cultured endothelial cells with ED50's of 0.6-7 microM. One of these peptides, containing residues 481-499 of TSP1, also inhibited vessel formation in granulation tissue invading sponges in vivo. These results suggest that the large TSP1 molecule employs at least two different structural domains and perhaps two different mechanisms to accomplish a single physiological function, the inhibition of neovascularization. The definition of short peptides from each of these domains that are able to block the angiogenic process may be of use in designing targeted inhibitors of the pathological neovascularization that underlies many diseases.
Detection of unknown signals based on spectral correlation measurements

The problem of detecting an unknown signal embedded in white Gaussian noise is addressed. A CFAR detector based on combining the information of the whole frequency-cycle-frequency plane is proposed. An analytical characterization of the detector is provided, and its detection capability evaluated. The FFT-Accumulation Method (FAM) is used to measure the SCF. Approximate analytic expressions of the probability of false alarm are provided.
Embolization of portal vein branches induces hepatocyte replication in swine: a potential step in hepatic gene therapy.

PURPOSE To determine whether embolization of portal vein branches would stimulate hepatocyte replication in pigs. MATERIALS AND METHODS The portal vein branches supplying 50%-70% of the liver were embolized in eight pigs by using a combination of coils and polyvinyl alcohol particles. The extent of embolization was assessed at portography in all animals and at computed tomography in one animal. Hepatocyte replication was determined by calculating the percentage of cells that incorporated bromodeoxyuridine into their nuclei. Animals survived up to 35 days after the procedure. RESULTS Embolization of the portal vein branches supplying the left and median lobes caused transient increases of less than 70% in portal vein pressures and of less than 100% in liver enzyme levels. Indocyanine green clearance was measured in two animals and decreased less than 50%. The percentage of replicating hepatocytes in the nonembolized lobe was 0% on day 0, 7% on day 2, 14% on day 7, and 2% on day 12. CONCLUSION Substantial hepatocyte replication occurred 2-7 days after embolization of portal vein branches. Further research will help determine if this procedure can facilitate retroviral transduction in large animals. If successful, the low morbidity of this method may allow its use in humans for gene therapy.
Moving cast shadow detection using physics-based features

Cast shadows induced by moving objects often cause serious problems to many vision applications. We present in this paper an online statistical learning approach to model the background appearance variations under cast shadows. Based on the bi-illuminant (i.e. direct light sources and ambient illumination) dichromatic reflection model, we derive physics-based color features under the assumptions of constant ambient illumination and light sources with common spectral power distributions. We first use one Gaussian mixture model (GMM) to learn the color features, which are constant regardless of the background surfaces or illuminant colors in a scene. Then, we build up one pixel based GMM for each pixel to learn the local shadow features. To overcome the slow convergence rate in the conventional GMM learning, we update the pixel-based GMMs through confidence-rated learning. The proposed method can rapidly learn model parameters in an unsupervised way and adapt to illumination conditions or environment changes. Furthermore, we demonstrate that our method is robust to scenes with few foreground activities and videos captured at low or unsteady frame rates.
Radiation-Hydrodynamics , Spectral , and Atomic Physics Modeling of Laser-Produced Plasma EUV Lithography Light Sources

Tin, lithium, and xenon laser-produced plasmas are attractive candidates as light sources for extreme ultraviolet lithography (EUVL). Simulation of the dynamics and spectral properties of plasmas created in EUVL experiments plays a crucial role in analyzing and interpreting experimental measurements, and in optimizing the 13.5 nm radiation from the plasma source. Developing a good understanding of the physical processes in EUVL plasmas is challenging, as it requires accurate modeling for the atomic physics of complex atomic systems, frequency-dependent radiation transport, hydrodynamics, and the ability to simulate emergent spectra and images that can be directly compared with experimental measurements. We have developed a suite of plasma and atomic physics codes to simulate in detail the radiative properties of hot plasmas. HELIOS-CR is a 1-D radiation-magnetohydrodynamics code used to simulate the dynamic evolution of laser-produced and z-pinch plasmas. Multi-frequency radiation transport can be computed using either fluxlimited diffusion or multi-angle models. HELIOS-CR also includes the capability to perform in-line non-LTE atomic kinetics calculations at each time step in the simulation. Energy source modeling includes laser energy deposition, radiation from external sources, and current discharges. The results of HELIOS-CR simulations can be post-processed using SPECT3D to generate images and spectra that include instrumental effects, and therefore can be directly compared with experimental measurements. Results from simulations of Sn laser-produced plasmas are presented, along with comparisons with experimental data. We discuss the sensitivity of the 13.5 nm conversion efficiency to laser intensity, wavelength, and pulse width, and show how the thickness of the Sn radiation layer affects the characteristics of the 13.5 nm emission.