Miracle-dz/UniFAR-FTUs huggingface dataset:
Face detection using improved LBP under Bayesian framework

In this paper, we present a novel face detection approach using improved local binary patterns (ILBP) as facial representation. ILBP feature is an improvement of LBP feature that considers both local shape and texture information instead of raw grayscale information and it is robust to illumination variation. We model the face and non-face class using multivariable Gaussian model and classify them under Bayesian framework. Extensive experiments show that the proposed method has an encouraging performance.
Involvement of Cajal-Retzius Neurons in Spontaneous Correlated Activity of Embryonic and Postnatal Layer 1 from Wild-Type and Reeler Mice

Cajal-Retzius (CR) cells are a transient population of neurons in developing cortical layer 1 that secrete reelin, a protein necessary for cortical lamination. Combining calcium imaging of cortical hemispheres and cross-correlation analysis, we previously found spontaneous correlated activity among non-CR neurons in postnatal rat layer 1. This correlated activity was blocked by GABAergic and glutamatergic antagonists, and we postulated that it was controlled by CR cells. We now investigate the correlated activity of embryonic and postnatal layer 1 in wild-type and reeler mice, mutant in the production of reelin. We find that mouse layer 1 also sustains patterned spontaneous activity and that CR cells participate in correlated networks. These networks are present in embryonic marginal zone and are blocked by GABAergic and glutamatergic antagonists. Surprisingly, network activity in reeler mice displays similar characteristics and pharmacological profile as in wild-type mice, although small differences are detected. Our results demonstrate that the embryonic marginal zone has correlated spontaneous activity that could serve as the scaffold for the development of intracortical connections. Our data also suggest that reelin does not have a major impact in the development of specific synaptic circuits in layer 1.
The Timing of Biological Carbon Sequestration and Carbon Abatement in the Energy Sector Under Optimal Strategies Against Climate Risks

This paper addresses the timing of the use of biological carbon sequestration and its capacity to alleviate the carbon constraint on the energy sector. We constructed a stochastic optimal control model balancing the costs of fossil emission abatement, the opportunity costs of lands allocated to afforestation, and the costs of uncertain climate damages. We show that a minor part of the sequestration potential should start immediately as a “brake”, slowing down both the rate of growth of concentrations and the rate of abatement in the energy sector, thus increasing the option value of the emission trajectories. But, most of the potential is put in reserve to be used as a “safety valve” after the resolution of uncertainty, if a higher and faster decarbonization is required: sequestration cuts off the peaks of costs of fossil abatement and postpones the pivoting of the energy system by up to two decades.
Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy

Epithelioid sarcoma (ES) is a soft tissue sarcoma of children and young adults for which the preferred treatment for localized disease is wide surgical resection. Medical management is to a great extent undefined, and therefore for patients with regional and distal metastases, the development of targeted therapies is greatly desired. In this review, we will summarize clinically relevant biomarkers (e.g., SMARCB1, CA125, dysadherin, and others) with respect to targeted therapeutic opportunities. We will also examine the role of EGFR, mTOR, and polykinase inhibitors (e.g., sunitinib) in the management of local and disseminated disease. Toward building a consortium of pharmaceutical, academic, and non-profit collaborators, we will discuss the state of resources for investigating ES with respect to cell line resources, tissue banks, and registries so that a roadmap can be developed toward effective biology-driven therapies.
Modeling of Carbon Tetrachloride Flow and Transport in the Subsurface of the 200 West Disposal Sites: Large-Scale Model Configuration and Prediction of Future Carbon Tetrachloride Distribution Beneath the 216-Z-9 Disposal Site

Three-dimensional simulations considered migration of dense, nonaqueous phase liquid (DNAPL) consisting of CT and co disposed organics in the subsurface as a function of the properties and distribution of subsurface sediments and of the properties and disposal history of the waste. Simulations of CT migration were conducted using the Water-Oil-Air mode of Subsurface Transport Over Multiple Phases (STOMP) simulator. A large-scale model was configured to model CT and waste water discharge from the major CT and waste-water disposal sites.
Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate

Candida glabrata is considered a major opportunistic fungal pathogen of humans. The capacity of this yeast species to cause infections is dependent on the ability to grow within the human host environment and to assimilate the carbon sources available. Previous studies have suggested that C. albicans can encounter glucose-poor microenvironments during infection and that the ability to use alternative non-fermentable carbon sources, such as carboxylic acids, contributes to the virulence of this fungus. Transcriptional studies on C. glabrata cells identified a similar response, upon nutrient deprivation. In this work, we aimed at analyzing biofilm formation, antifungal drug resistance, and phagocytosis of C. glabrata cells grown in the presence of acetic acid as an alternative carbon source. C. glabrata planktonic cells grown in media containing acetic acid were more susceptible to fluconazole and were better phagocytosed and killed by macrophages than when compared to media lacking acetic acid. Growth in acetic acid also affected the ability of C. glabrata to form biofilms. The genes ADY2a, ADY2b, FPS1, FPS2, and ATO3, encoding putative carboxylate transporters, were upregulated in C. glabrata planktonic and biofilm cells in the presence of acetic acid. Phagocytosis assays with fps1 and ady2a mutant strains suggested a potential role of FPS1 and ADY2a in the phagocytosis process. These results highlight how acidic pH niches, associated with the presence of acetic acid, can impact in the treatment of C. glabrata infections, in particular in vaginal candidiasis.
Mouse allergen. I. The prevalence of mouse allergen in inner-city homes. The National Cooperative Inner-City Asthma Study.

BACKGROUND Although mouse allergen is a well-defined cause of IgE-mediated hypersensitivity in occupational settings, it has not been well studied in the general population. OBJECTIVE We sought to determine the prevalence of mouse allergen in inner-city homes. METHODS A subset of 608 homes from the National Cooperative Inner-City Asthma Study population had dust samples adequate for analysis of mouse allergen. In addition, data regarding the demographics and housing of the subjects were related to the mouse allergen levels. RESULTS Ninety-five percent of all homes had detectable mouse allergen (Mus m 1) in at least one room, with the highest levels found in kitchens (kitchen: range, 0-618 microg/g; median, 1.60 microg/g; bedroom: range, 0-294 microg/g; median, 0.52 microg/g; television-living room: range, 0-203 microg/g; median, 0. 57 microg/g). By city, 100% of the kitchens in Baltimore had detectable mouse allergen, with the lowest percentage (74%) in Cleveland. Mouse allergen levels correlated among rooms (R = 0.65-0. 75). Forty-nine percent of the homes had reported problems with mice within the last year, and 29% of the homes had evidence of mice in one or more rooms on home inspection and had higher levels of mouse allergen (P =.0001). Higher allergen levels were also associated with evidence of cockroach infestation in any room (P =.006). None of the other subject or housing demographics evaluated were associated with a higher prevalence or level of mouse allergen. CONCLUSIONS We conclude that mouse allergen is widely distributed in inner-city homes and that cockroach infestation is associated with high mouse allergen levels.
Load-Carrying Capacity of the Human Cervical Spine in Compression Is Increased Under a Follower Load

Study Design. An experimental approach was used to test human cadaveric cervical spine specimens. Objective. To assess the response of the cervical spine to a compressive follower load applied along a path that approximates the tangent to the curve of the cervical spine. Summary of Background Data. The compressive load on the human cervical spine is estimated to range from 120 to 1200 N during activities of daily living. Ex vivo experiments show it buckles at approximately 10 N. Differences between the estimated in vivo loads and the ex vivo load-carrying capacity have not been satisfactorily explained. Methods. A new experimental technique was developed for applying a compressive follower load of physiologic magnitudes up to 250 N. The experimental technique applied loads that minimized the internal shear forces and bending moments, loading the specimen in nearly pure compression. Results. A compressive vertical load applied in the neutral and forward-flexed postures caused large changes in cervical lordosis at small load magnitudes. The specimen collapsed in extension or flexion at a load of less than 40 N. In sharp contrast, the cervical spine supported a load of up to 250 N without damage or instability in both the sagittal and frontal planes when the load path was tangential to the spinal curve. The cervical spine was significantly less flexible under a compressive follower load compared with the hypermobility demonstrated under a compressive vertical load (P < 0.05). Conclusion. The load-carrying capacity of the ligamentous cervical spine sharply increased under a compressive follower load. This experiment explains how a whole cervical spine can be lordotic and yet withstand the large compressive loads estimated in vivo without damage or instability.
Impact of coercive measures on life stories: qualitative study

Background How people integrate the experience of involuntary hospital admission and treatment into their life narrative has not been explored systematically. Aims To establish a typology of coercion perspectives and styles of integration into life stories. Method Transcripts of recorded interviews with 15 persons who had previously been involuntarily admitted to hospital were coded and analysed thematically using a modified grounded theory approach. Results With hindsight, people viewed the experience of involuntary hospital admission as a ‘necessary emergency brake’, an ‘unnecessary overreaction’ or a ‘practice in need of improvement’. With respect to how they integrated the experience into their life narratives, participants viewed it as ‘over and not to be recalled’, a ‘life-changing experience’ or a ‘motivation for political engagement’. Conclusions The participants' diverse and differentiated perspectives on coercive measures and their different styles of integration suggest that people may come to accept coercive measures as necessary when confronted with danger to self or others. However, the implementation of coercion needs to be improved substantially to counteract possible long-term adverse effects.
A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome

Purpose To identify risk factors and develop a prediction model for the development of profound and recurrent shock amongst children presenting with dengue shock syndrome (DSS) Methods We analyzed data from a prospective cohort of children with DSS recruited at the Paediatric Intensive Care Unit of the Hospital for Tropical Disease in Ho Chi Minh City, Vietnam. The primary endpoint was “profound DSS”, defined as ≥2 recurrent shock episodes (for subjects presenting in compensated shock), or ≥1 recurrent shock episodes (for subjects presenting initially with decompensated/hypotensive shock), and/or requirement for inotropic support. Recurrent shock was evaluated as a secondary endpoint. Risk factors were pre-defined clinical and laboratory variables collected at the time of presentation with shock. Prognostic model development was based on logistic regression and compared to several alternative approaches. Results The analysis population included 1207 children of whom 222 (18%) progressed to “profound DSS” and 433 (36%) had recurrent shock. Independent risk factors for both endpoints included younger age, earlier presentation, higher pulse rate, higher temperature, higher haematocrit and, for females, worse hemodynamic status at presentation. The final prognostic model for “profound DSS” showed acceptable discrimination (AUC=0.69 for internal validation) and calibration and is presented as a simple score-chart. Conclusions Several risk factors for development of profound or recurrent shock among children presenting with DSS were identified. The score-chart derived from the prognostic models should improve triage and management of children presenting with DSS in dengue-endemic areas.
Improving Virus Taxonomy by Recontextualizing Sequence-Based Classification with Biologically Relevant Data: the Case of the Alphacoronavirus 1 Species

Our work focuses on improving the classification of the Alphacoronavirus genus. The Alphacoronavirus 1 species groups viruses of veterinary importance that infect distinct mammalian hosts and includes canine and feline coronaviruses and transmissible gastroenteritis virus. It is the prototype species of the Alphacoronavirus genus; however, it encompasses biologically distinct viruses. To better characterize this prototypical species, we performed phylogenetic analyses based on the sequences of the spike protein, one of the main determinants of tropism and pathogenesis, and reveal the existence of two subgroups or clades that fit with previously established serotype demarcations. We propose a new clade designation to better classify Alphacoronavirus 1 members. ABSTRACT The difficulties related to virus taxonomy have been amplified by recent advances in next-generation sequencing and metagenomics, prompting the field to revisit the question of what constitutes a useful viral classification. Here, taking a challenging classification found in coronaviruses, we argue that consideration of biological properties in addition to sequence-based demarcations is critical for generating useful taxonomy that recapitulates complex evolutionary histories. Within the Alphacoronavirus genus, the Alphacoronavirus 1 species encompasses several biologically distinct viruses. We carried out functionally based phylogenetic analysis, centered on the spike gene, which encodes the main surface antigen and primary driver of tropism and pathogenesis. Within the Alphacoronavirus 1 species, we identify clade A (encompassing serotype I feline coronavirus [FCoV] and canine coronavirus [CCoV]) and clade B (grouping serotype II FCoV and CCoV and transmissible gastroenteritis virus [TGEV]-like viruses). We propose this clade designation, along with the newly proposed Alphacoronavirus 2 species, as an improved way to classify the Alphacoronavirus genus. IMPORTANCE Our work focuses on improving the classification of the Alphacoronavirus genus. The Alphacoronavirus 1 species groups viruses of veterinary importance that infect distinct mammalian hosts and includes canine and feline coronaviruses and transmissible gastroenteritis virus. It is the prototype species of the Alphacoronavirus genus; however, it encompasses biologically distinct viruses. To better characterize this prototypical species, we performed phylogenetic analyses based on the sequences of the spike protein, one of the main determinants of tropism and pathogenesis, and reveal the existence of two subgroups or clades that fit with previously established serotype demarcations. We propose a new clade designation to better classify Alphacoronavirus 1 members.
Object Tracking With Only Background Cues

Background cues mainly play a supplementary or accompanying role in most previous approaches for object tracking. If object tracking is treated as a binary target/background classification problem, then the similarity with the target and the difference from the background can be considered equally informative. This leads to an interesting question: is it possible to perform object tracking using background cues only? To answer this question, we propose an object tracking approach that utilizes background cues only. The extensive experimental results positively validate the possibility of performing object tracking using background cues only. The results revealed in this paper also provide a new reference in designing future object tracking methods.
SentiCap: Generating Image Descriptions with Sentiments

The recent progress on image recognition and language modeling is making automatic description of image content a reality. However, stylized, non-factual aspects of the written description are missing from the current systems. One such style is descriptions with emotions, which is commonplace in everyday communication, and influences decision-making and interpersonal relationships. We design a system to describe an image with emotions, and present a model that automatically generates captions with positive or negative sentiments. We propose a novel switching recurrent neural network with word-level regularization, which is able to produce emotional image captions using only 2000+ training sentences containing sentiments. We evaluate the captions with different automatic and crowd-sourcing metrics. Our model compares favourably in common quality metrics for image captioning. In 84.6% of cases the generated positive captions were judged as being at least as descriptive as the factual captions. Of these positive captions 88% were confirmed by the crowd-sourced workers as having the appropriate sentiment.
Towards an understanding of the role of business intelligence systems in organisational knowing

Recent advances in information technology (IT), such as the advent of business intelligence (BI) systems, have increased the ability of organisations to collect and analyse data to support decisions. There is little focus to date, however, on how BI systems might play a role in organisational knowledge creation – in organisational knowing. We develop a conceptual framework of organisational knowing based on a synthesis of the literature, and use this as a framework to investigate how BI systems facilitate knowing in a case organisation. We identify two practices triggered by BI systems that distinguish them from prior applications of IT: the ability to initiate problem articulation and dialogue, and that of data selection (e.g. to address information needs of organisational decision makers at different managerial levels). This study provides empirical evidence of the performative outcome of BI systems in relation to organisational knowing through the practices of articulation and data selection. It provides a practice perspective on BI and focuses on the role of BI systems in organisational knowing thereby opening up a new departure for BI research that considers the implications of BI systems in organisations with actual practice in mind.
On the Economics of Polygyny

About 80\% of all societies recorded by anthropologists are polygynous (men have many wives). Even our own society is less monogamous than claimed. This paper attempts to explain such mysteries as why bride prices and dowries are not ``opposites'', why polygamous societies are usually characterized by positive bride prices and dowry is mainly confined to monogamous societies, why polyandry (women having multiple husbands) is rare, but not extinct, and why the more you have to pay for a wife the better you will treat her.
Guidelines for diagnosis and management of pediatric food allergy in Japan.

In Japan, the prevalence of food allergy has been increasing and a variety of problems have emerged regarding what should be considered a food allergy. A treatment regimen consists of avoiding the offending food (elimination diet therapy) and receiving nourishment from alternative foods (substitutional diet therapy). There is a growing concern that confusion has resulted from the lack of a consensus on the procedures for diagnosing and treating food allergies. The Food Allergy Committee of the Japanese Society of Pediatric Allergy and Clinical Immunology established the "Guidelines for Diagnosis and Management of Pediatric Food Allergy. " Definition, classification, pathophysiology, clinical disorders and management of food allergy are discussed and determined.
Sampling the Arabidopsis Transcriptome with Massively Parallel Pyrosequencing1[W][OA]

Massively parallel sequencing of DNA by pyrosequencing technology offers much higher throughput and lower cost than conventional Sanger sequencing. Although extensively used already for sequencing of genomes, relatively few applications of massively parallel pyrosequencing to transcriptome analysis have been reported. To test the ability of this technology to provide unbiased representation of transcripts, we analyzed mRNA from Arabidopsis (Arabidopsis thaliana) seedlings. Two sequencing runs yielded 541,852 expressed sequence tags (ESTs) after quality control. Mapping of the ESTs to the Arabidopsis genome and to The Arabidopsis Information Resource 7.0 cDNA models indicated: (1) massively parallel pyrosequencing detected transcription of 17,449 gene loci providing very deep coverage of the transcriptome. Performing a second sequencing run only increased the number of genes identified by 10%, but increased the overall sequence coverage by 50%. (2) Mapping of the ESTs to their predicted full-length transcripts indicated that all regions of the transcript were well represented regardless of transcript length or expression level. Furthermore, short, medium, and long transcripts were equally represented. (3) Over 16,000 of the ESTs that mapped to the genome were not represented in the existing dbEST database. In some cases, the ESTs provide the first experimental evidence for transcripts derived from predicted genes, and, for at least 60 locations in the genome, pyrosequencing identified likely protein-coding sequences that are not now annotated as genes. Together, the results indicate massively parallel pyrosequencing provides novel information helpful to improve the annotation of the Arabidopsis genome. Furthermore, the unbiased representation of transcripts will be particularly useful for gene discovery and gene expression analysis of nonmodel plants with less complete genomic information.
Random graphs with arbitrary i.i.d. degrees

In this paper we derive results concerning the connected components and the diameter of random graphs with an arbitrary i.i. d. degree sequence. We study these properties primarily, but not exclusively, when the tail of the degree distribution is regularly varying with exponent 1 − τ. There are three distinct cases: (i) τ > 3, where the degrees have finite variance, (ii) τ ∈ (2,3), where the degrees have infinite variance, but finite mean, and (iii) τ ∈ (1,2), where the degrees have infinite mean. These random graphs can serve as models for complex networks where degree power laws are observed. Our results are twofold. First, we give a criterion when there exists a unique largest connected component of size proportional to the size of the graph, and study sizes of the other connected components. Secondly, we establish a phase transition for the diameter when τ ∈ (2,3). Indeed, we show that for τ > 2 and when nodes with degree 2 are present with positive probability, the diameter of the random graph is, with high probability, bounded below by a constant times the logarithm of the size of the graph. On the other hand, assuming that all degrees are at least 3 or more, we show that, for τ ∈ (2,3), the diameter of the graph is with high probability bounded from above by a constant times the loglog of the size of the graph.