Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of biliary cystic tumors: a multi-institutional analysis of a rare liver tumor.

OBJECTIVE To characterize clinical and radiological features associated with biliary cystic tumors (BCTs) of the liver, and to define recurrence-free and overall survival. BACKGROUND Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) are rare tumors that arise in the liver. METHODS Between 1984 and 2013, 248 patients who underwent surgical resection of BCA or BCAC were identified. Clinical and outcome data were analyzed. RESULTS Median total bilirubin, CA19-9, and carcinoembryonic antigen (CEA) levels were 0.6 mg/dL, 15.0 U/mL, and 2.7 ng/mL, respectively. Preoperative imaging included computed tomography only (62.5%), magnetic resonance imaging only (6.9%), or CT + MRI (18.5%). Features on cross-sectional imaging included multiloculation (56.9%), mural nodularity (16.5%), and biliary ductal dilatation (17.7%). The presence of these factors did not reliably predict BCAC versus BCA (sensitivity, 81%; specificity, 21%). Median biliary cyst size was 10.0 cm (interquartile range, 7-13 cm). Operative interventions included unroofing/partial excision of the lesion (14.1%), less than hemihepatectomy (48.8%), or hemi-/extended hepatectomy (36.3%). On pathology most lesions were BCA (89.1%), whereas 27 (10.9%) were BCAC. At last follow-up, there were 46 (18.3%) recurrences; 2 patients who initially had BCA recurred with BCAC. Median overall survival was 18.1 years; 1-year, 3-year, and 5-year survival was 95.0%, 86.8%, and 84.2%, respectively. Long-term outcomes were associated with BCAC versus BCA, as well as the presence of spindle cell/ovarian stroma (both P < 0.05). CONCLUSIONS Among patients undergoing surgery for BCT, associated malignancy was uncommon (10%) and no preoperative findings reliably predicted underlying BCAC. After excision of BCA, long-term outcomes were good; however, patients with BCAC had a worse long-term prognosis.
Experience of Elementary School Students with the Use of WebQuests.

Accepted: 21.05. 2013 The aim of this study was to examine the perspectives of primary school students on the use of WebQuests in learning. There were nine graduate students, twenty-six 4th grade and thirty 5th grade pupils involved in this study, which took place over eight weeks in a graduate course. The graduate students designed and developed their WebQuests as a project based on their interests. The researcher gave a questionnaire, including open-ended questions, to both graduate students and primary school students, who stated their perceptions of the development and implementation of the WebQuests. The researcher only examined the views of the primary school students on the use of WebQuests in learning. The study shows that both 4th and 5th grade pupils found something very interesting about WebQuests, which enhanced their motivation to learn. The students also commented that they played, had fun and learned using WebQuests.
Total Ankle Arthroplasty With Bone Defects

An alternative total ankle arthroplasty procedure has been developed that capitalizes on the strength of local bone when posterior bone stock of the talus is insufficient. This case report describes the 2-year postoperative results of a modular total ankle arthroplasty on a patient with significant bone loss of the posterior talus.
Joint remembering: Constructing an account of shared experience through conversational discourse

The object of study is the ways in which people construct a joint account, in conversational discourse, of a particular common experience. The data source is the recorded conversation of a group of eight people who are recalling together the substance and storyline of the feature film “E.T. ,” which they had all recently seen. Conversational joint remembering is described in terms of three hierarchically related functions: (1) framing and orientation—the establishment of criteria for joint recall, and the ways in which individuals accordingly locate themselves vis‐a‐vis the unfolding account; (2) correspondence functions—including a “semantic function” through which experiences are put into words, and a “continuity function” which concerns the ordering of things recalled; and (3) validation function—a variety of means by which the joint account is constructed as a mnemonic consensus, jointly agreed. These three functions and their subcomponents are derived from a qualitative, content‐oriented treatment of .
The 15-item Systemic Clinical Outcome and Routine Evaluation (SCORE-15) Scale: Portuguese Validation Studies

Abstract This study reports on the validity of the 15-item Portuguese version of the Systemic Clinical Outcome Routine Evaluation (SCORE-15; Vilaça, Silva, & Relvas, 2014), a brief and comprehensive measure of family functioning. Previous studies with SCORE-15 show that this version replicates the three-factor solution found for the original English version: Family strengths, Family communication and Family difficulties. In addition to reviewing previous studies, this article analyses the discriminant, convergent and predictive validity of the Portuguese SCORE-15. To do so, the SCORE-15 was administered to family members attending systemic family or couple’s therapy at the start of the first and fourth sessions and also to a group of non-clinical individuals. Overall, data are reported from 618 participants, including 136 from families attending systemic therapy and 482 community family members. Comparisons of community and clinical samples (discriminant validity) showed statistically significant differences for the total scale and subscales (p < .001), with the community participants presenting healthier family functioning than the clinical ones. Analyses using SCORE-15 and the Quality of Life – adult version, another family measure applied simultaneously (convergent validity), indicate that both scales are significantly (p < .01) and moderately (r = –.47) correlated. Mean score analysis of SCORE-15’s therapeutic sensitivity to change (predictive validity) showed that only the Family communication subscale was sensitive to statistically significant improvement (p < .05) from session 1 to session 4, whereas the SCORE-15’s reliability change index points to its ability to detect clinical improvements (RCI = 14%).
Effects of 2-Week Treatment With Temazepam and Diphenhydramine in Elderly Insomniacs: A Randomized, Placebo-Controlled Trial

A randomized, controlled, crossover clinical study compared 14-night treatment with 15 mg temazepam, 50 mg diphenhydramine, and placebo in elderly individuals with insomnia (mean age, 73.9 years; range, 70-89 years). Primary outcome measures were subjective assessments of sleep recorded on sleep diaries. Secondary measures were the morning-after psychomotor impairment, using the digit symbol substitution task and the manual tracking task, and the morning-after memory impairment, using a free-recall procedure. Results showed sleep improvements with 15 mg temazepam compared with placebo-sleep quality (mean score, 3.3 ± 0.9 vs 2.9 ± 0.8; P = 0.03), total sleep time (6.9 ± 1.0 hours vs 6.3 ±1.3 hours; P = 0.02), number of awakenings (1.5 ± 1.3 vs 2.0 ± 1.2; P < 0.001), and sleep-onset latency (25 ± 22 minutes vs 37 ± 25 minutes; P = 0.03). Improvements were seen with diphenhydramine treatment compared with placebo on the number of awakenings only (mean, 1.7 ± 1.1 vs 2.0 ± 1.2; P < 0.05). Numbers of adverse events reported were similar after all treatments, although there was 1 fall during temazepam treatment. Findings indicate that temazepam is more effective than diphenhydramine when compared with placebo at the doses tested, although this advantage is mitigated by the risk of falls associated with temazepam use. The choice of agent to use in the elderly must consider these relative benefits and risks.
Better Evaluation for Grammatical Error Correction

We present a novel method for evaluating grammatical error correction. The core of our method, which we call MaxMatch (M2), is an algorithm for efficiently computing the sequence of phrase-level edits between a source sentence and a system hypothesis that achieves the highest overlap with the gold-standard annotation. This optimal edit sequence is subsequently scored using F1 measure. We test our M2 scorer on the Helping Our Own (HOO) shared task data and show that our method results in more accurate evaluation for grammatical error correction.
Factors Influencing Changes in Chinese Management Accounting Practices

This study provides insight into the factors that influence change in Chinese management accounting practices. Multivariate analysis indicates that the size of the firm, foreign partner and level of knowledge of senior managers and employees have positive bearing on the changes in management accounting practices of the foreign-partnered joint ventures. The size and level of knowledge of senior managers appear to influence changes in management accounting practices. However, no support is found for the hypothesis that the Chinese government has a significant influence on the changes in management accounting practices of joint ventures and state-owned enterprises.
Sex Differences and Conjugal Interdependence on Parenthood Stress and Adjustment: A Dyadic Longitudinal Chinese Study

Abstract This study explored sex differences and conjugal interdependence in stress and adjustment of young Chinese fathers and mothers in the half-year period following the birth of their children. Ninety pairs of married couples took part in this panel study conducted twice at six weeks and six months after the birth of their children. Results showed that (a) Wives reported heightened stress, worse health and lower marital satisfaction than husbands, (b) a substantial degree of conjugal interdependence was revealed in significant correlations of health and marital satisfaction between partners, and (c) conjugal discrepancy in stress had an adverse impact on personal well-being and marital satisfaction of wives. These results were discussed in relation to existing theories and research, as well as the distinct characteristics of contemporary Chinese society.
Urinary bladder cancer in Wegener’s granulomatosis: risks and relation to cyclophosphamide

Objective: To assess and characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener’s granulomatosis. Methods: In the population based, nationwide Swedish Inpatient Register a cohort of 1065 patients with Wegener’s granulomatosis, 1969–95, was identified. Through linkage with the Swedish Cancer Register, all subjects in this cohort diagnosed with bladder cancer were identified. Nested within the cohort, a matched case-control study was performed to estimate the association between cyclophosphamide and bladder cancer using odds ratios (ORs) as relative risk. In the cohort the cumulative risk of bladder cancer after Wegener’s granulomatosis, and the relative prevalence of a history of bladder cancer at the time of diagnosis of Wegener’s granulomatosis, were also estimated. Results: The median cumulative doses of cyclophosphamide among cases (n = 11) and controls (n = 25) were 113 g and 25 g, respectively. The risk of bladder cancer doubled for every 10 g increment in cyclophosphamide (OR = 2.0, 95% confidence interval (CI) 0.8 to 4.9). Treatment duration longer than 1 year was associated with an eightfold increased risk (OR = 7.7, 95% CI 0.9 to 69). The absolute risk for bladder cancer in the cohort reached 10% 16 years after diagnosis of Wegener’s granulomatosis, and a history of bladder cancer was (non-significantly) twice as common as expected at the time of diagnosis of Wegener’s granulomatosis. Conclusion: The results indicate a dose-response relationship between cyclophosphamide and the risk of bladder cancer, high cumulative risks in the entire cohort, and also the possibility of risk factors operating even before Wegener’s granulomatosis.
Where to Find Sex Offenders: An Examination of Residential Locations and Neighborhood Conditions

Drawing on observational data of the residential locations of a sample of convicted sex offenders in Seminole County, Florida, this study explores the residential proximity of sex offenders to places potential child victims congregate and the neighborhood conditions/structures present in such communities. Analysis draws on routine activities theory and incorporates objective measurements of neighborhood disorganization and negative attributes. Results suggest that sex offenders are only moderately likely to reside in close proximity to child congregation locations and the neighborhoods of sex offenders' residences are only fairly disorganized. Additionally, only about one‐half of the sample subject to restrictions on residential locations is in compliance. The utility of incorporating measures of community conditions/structures to routine activities theory is somewhat beneficial for the study of sex offenders.
Does Brief Dynamic Psychotherapy Reduce the Relapse Rate of Panic Disorder

Background: Although panic disorder can be effectively alleviated by drug treatment, the relapse rate is high. By adding brief dynamic psychotherapy focused on the Psychosocial vulnerability of patients with panic disorder to an established drug treatment regimen, we hypothesized that this would result in a lower relapse rate after pharmacotherapy. Methods: Patients with panic disorder (defined by DSM\x=req-\ III-R) were randomized to treatment with either clomipramine for 9 months (n=20), or clomipramine for 9 months combined with 15 weekly sessions of brief dynamic psychotherapy (n=20). Measures of anxiety and depression were collected at intake and at regular intervals. The patients had blind follow-up interviews at 6, 12, and 18 months after beginning treatment. Results: All patients in both groups became free of panic attacks within 26 weeks of the start of treatment. On termination of pharmacotherapy, the relapse rate was significantly higher in the clomipramine-only group during the follow-up period. There were significantly lower scores for most anxiety measures in the clomipramine plus psychotherapy group at the 9-month follow-up. Conclusion: The addition of brief dynamic psychotherapy to treatment with clomipramine significantly reduces the relapse rate of panic disorder compared with clomipramine treatment alone. Arch Gen Psychiatry. 1996;53:689-694
LTE in unlicensed spectrum: are we there yet?

In this work, we explore the potential and impact of unlicensed LTE on WiFi in unlicensed spectrum. Our experiments demonstrate that the large asymmetry in the channel access methodologies employed by WiFi and LTE (carrier sensing/notification in WiFi, energy sensing alone in LTE-U), can result LTE-U completely blocking WiFi transmissions, and causing significant degradation to either technologies from collisions. We address this critical sensing asymmetry with Ultron, a LTE-WiFi co-existence solution that integrates WiFi's carrier sensing and notification mechanisms into LTE, without any modifications to the LTE PHY standard. Ultron operates at the LTE base station and consists of two key components: (a) WiFi embedding that embeds appropriate data into the LTE-subframes through an intelligent reverse-engineering of the LTE PHY, so as to realize a WiFi PLCP preamble-header transmission over the air directly using the LTE PHY; and (b) scalable WiFi sensing that employs a single WiFi interface and maximizes its carrier sensing benefits to all the unlicensed channels operating at the LTE node. Our evaluations demonstrate that Ultron can increase the WiFi and LTE throughput by 5x and 6x respectively, resulting from a sharp reduction in LTE-WiFi interference.
Cell fusion in tumor development and progression: Occurrence of cell fusion in primary methylcholanthrene‐induced tumorigenesis

Definitive evidence for the occurrence of cell fusion in tumorigenesis was sought in methylcholanthrene‐induced sarcomas. This was approached by using allophenic mice generated from strains differing for electrophoretic variants of the ubiquitous, dimeric enzyme glucose phosphate isomerase, with fusion assessed by heterodimer formation. Eighty‐three carefully trimmed primary tumor samples (from 23 individual tumors in allophenic mice) were analyzed, as were 1,140 clones derived from them. In all primary tumor samples, zymograms exhibited one GPI homopolymeric band. Expression of a hybrid band (indicative of a fusion event) was not observed in these samples. However, 9 (0.8%) of the tumor clones demonstrated a distinct and reproducible hybrid band which was uniformly lost upon recloning. Our data suggest that cell fusion, although uncommon, occurs in the clonogenic cell fraction during primary MCA tumorigenesis and is followed rapidly by chromosome segregation.
Harnessing Mineral Resources in Gwanda District of Zimbabwe: A Myth or a Reality?

The article examines strategies of harnessing mineral resources for community empowerment, poverty reduction and infrastructure development in mining areas of Zimbabwe. Despite abundant mineral resources, the majority of Zimbabwean indigenous communities living close to the mines have limited access to directly or indirectly benefit from the mineral resources. Using a descriptive survey to collect data, this research article gives a strong proposition on how the Indigenisation and Economic Empowerment Act can be used as a vehicle of harnessing mineral resources. The article argues that pro poor mining policies that ensure the harnessing of mineral resources for community empowerment, poverty reduction and infrastructure development are paramount. The article further argues that the Indigenous and Economic Empowerment Act needs to be harmonised with other sector legislation in the country. The article concludes that the development of infrastructure and provision of public utilities such as electricity, water, establishing micro-credit to small and medium enterprises and implementing broad-based indigenisation policies are some of the strategies of improving rural livelihoods. Similarly direct and indirect linkages between the mining sector and local economy could be enhanced through the provision of food supply to the mine, manufacture of mining inputs, provision of security services and supply of labour by the local community. The article recommends that the harmonisation of legislation that has an effect on harnessing of mineral resources by local communities will ensure community empowerment, poverty reduction and infrastructure development.
Attitude Changes Reported by College Students Who Tutored Children in Reading

This study had 2 purposes: (a) to examine the validity and reliability of a questionnaire developed to determine if college students who tutored elementary school children reported attitude changes and (b) to determine if there was attitude change along the 4 proposed dimensions of the questionnaire: attitude toward self, children, tutoring, and others. Participants were 133 college students who tutored in an America Reads Challenge program. Factor analysis yielded good reliability supporting the validity of the questionnaire, and significant positive attitude changes were observed on all 4 dimensions. The change in attitude was explained as collateral learning. These findings build on the results of previous investigations and have implications for students in college and university learning assistance centers.
Learning to Recognize Pedestrian Attribute

Learning to recognize pedestrian attributes at far distance is a challenging problem in visual surveillance since face and body close-shots are hardly available; instead, only far-view image frames of pedestrian are given. In this study, we present an alternative approach that exploits the context of neighboring pedestrian images for improved attribute inference compared to the conventional SVM-based method. In addition, we conduct extensive experiments to evaluate the informativeness of background and foreground features for attribute recognition. Experiments are based on our newly released pedestrian attribute dataset, which is by far the largest and most diverse of its kind.
Home-Based Aerobic Interval Training Improves Peak Oxygen Uptake Equal to Residential Cardiac Rehabilitation: A Randomized, Controlled Trial

Aerobic capacity, measured as the peak oxygen uptake, is a strong predictor of survival in cardiac patients. Aerobic interval training (AIT), walking/running four times four minutes at 85–95% of peak heart rate, has proven to be effective in increasing peak oxygen uptake in coronary heart disease patients. As some patients do not attend organized rehabilitation programs, home-based exercise should be an alternative. We investigated whether AIT could be performed effectively at home, and compared the effects on peak oxygen uptake with that observed after a standard care, four-week residential rehabilitation. Thirty patients undergoing coronary artery bypass surgery were randomized to residential rehabilitation or home-based AIT. At six months follow-up, peak oxygen uptake increased 4.6 (±2.7) and 3.9 (±3.6) mL·kg−1 min−1 (both p<0.005, non-significant between-group difference) after residential rehabilitation and AIT, respectively. Quality of life increased significantly in both groups, with no statistical significant difference between groups. We found no evidence for a different treatment effect between patients randomized to home-based AIT compared to patients attending organized rehabilitation (95% confidence interval −1.8, 3.5). AIT patients reported good adherence to exercise training. Even though these first data indicate positive effects of home-based AIT in patients undergoing coronary artery bypass surgery, more studies are needed to provide supporting evidence for the application of this rehabilitation strategy. Trial Registration ClinicalTrials.gov NCT00363922
Instructions for use Title Autophagy inhibits viral genome replication and gene expression stages in West Nile virus infection

Title Autophagy inhibits viral genome replication and gene expression stages in West Nile virus infection Author(s) Kobayashi, Shintaro; Orba, Yasuko; Yamaguchi, Hiroki; Takahashi, Kenta; Sasaki, Michihito; Hasebe, Rie; Kimura, Takashi; Sawa, Hirofumi Citation Virus Research, 191: 83-91 Issue Date 2014-10-13 Doc URL http://hdl.handle. net/2115/57541 Type article (author version) Additional Information There are other files related to this item in HUSCAP. Check the above URL. File Information West Nile virus Autophagy 14.pdf
Housing data-based socioeconomic index and risk of invasive pneumococcal disease: an exploratory study

SUMMARY We previously developed and validated an index of socioeconomic status (SES) termed HOUSES (housing-based index of socioeconomic status) based on real property data. In this study, we assessed whether HOUSES overcomes the absence of SES measures in medical records and is associated with risk of invasive pneumococcal disease (IPD) in children. We conducted a population-based case-control study of children in Olmsted County, MN, diagnosed with IPD (1995–2005). Each case was age- and gender-matched to two controls. HOUSES was derived using a previously reported algorithm from publicly available housing attributes (the higher HOUSES, the higher the SES). HOUSES was available for 92·3% (n = 97) and maternal education level for 43% (n = 45). HOUSES was inversely associated with risk of IPD in unmatched analysis [odds ratio (OR) 0·22, 95% confidence interval (CI) 0·05–0·89, P = 0·034], whereas maternal education was not (OR 0·77, 95% CI 0·50–1·19, P = 0·24). HOUSES may be useful for overcoming a paucity of conventional SES measures in commonly used datasets in epidemiological research.