Miracle-dz/UniFAR-FTUs huggingface dataset:
Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications

It is now increasingly appreciated that inflammation is not limited to the control of pathogens by the host, but rather that sterile inflammation which occurs in the absence of viral or bacterial pathogens, accompanies numerous disease states, none more so than the complications that arise as a result of hyperglycaemia. Individuals with type 1 or type 2 diabetes mellitus (T1D, T2D) are at increased risk of developing cardiac and vascular complications. Glucose and blood pressure lowering therapies have not stopped the advance of these morbidities that often lead to fatal heart attacks and/or stroke. A unifying mechanism of hyperglycemia-induced cellular damage was initially proposed to link elevated blood glucose levels with oxidative stress and the dysregulation of metabolic pathways. Pre-clinical evidence has, in most cases, supported this notion. However, therapeutic strategies to lessen oxidative stress in clinical trials has not proved efficacious, most likely due to indiscriminate targeting by antioxidants such as vitamins. Recent evidence now suggests that oxidative stress is a major driver of inflammation and vice versa, with the latest findings suggesting not only a key role for inflammatory pathways underpinning metabolic and haemodynamic dysfunction in diabetes, but furthermore that these perturbations are driven by activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome. This review will address these latest findings with an aim of highlighting the interconnectivity between oxidative stress, NLRP3 activation and inflammation as it pertains to cardiac and vascular injury sustained by diabetes. Current therapeutic strategies to lessen both oxidative stress and inflammation will be emphasized. This will be placed in the context of improving the burden of these diabetic complications.
Predation of Apiomerus pilipes (Fabricius) (Hemiptera, Reduviidae, Harpactorinae, Apiomerini) over Meliponinae bees (Hymenoptera, Apidae), in the State of Amazonas, Brazil

O presente trabalho registra a ocorrencia de intensa atividade predatoria de Apiomerus pilipes (Fabricius, 1787) (Hemiptera, Reduviidae, Harpactorini, Apiomerini) sobre operarias adultas de meliponineos (Hymenoptera, Apidae), no meliponario experimental do Instituto Nacional de Pesquisas da Amazonia (INPA, Manaus), Estado do Amazonas, Brasil. O meliponario se encontra num fragmento de vegetacao secundaria no proprio INPA.
On the dependence of response inhibition processes on sensory modality

The ability to inhibit responses is a central sensorimotor function but only recently the importance of sensory processes for motor inhibition mechanisms went more into the research focus. In this regard it is elusive, whether there are differences between sensory modalities to trigger response inhibition processes. Due to functional neuroanatomical considerations strong differences may exist, for example, between the visual and the tactile modality. In the current study we examine what neurophysiological mechanisms as well as functional neuroanatomical networks are modulated during response inhibition. Therefore, a Go/NoGo‐paradigm employing a novel combination of visual, tactile, and visuotactile stimuli was used. The data show that the tactile modality is more powerful than the visual modality to trigger response inhibition processes. However, the tactile modality loses its efficacy to trigger response inhibition processes when being combined with the visual modality. This may be due to competitive mechanisms leading to a suppression of certain sensory stimuli and the response selection level. Variations in sensory modalities specifically affected conflict monitoring processes during response inhibition by modulating activity in a frontal parietal network including the right inferior frontal gyrus, anterior cingulate cortex and the temporoparietal junction. Attentional selection processes are not modulated. The results suggest that the functional neuroanatomical networks involved in response inhibition critically depends on the nature of the sensory input. Hum Brain Mapp 38:1941–1951, 2017. © 2017 Wiley Periodicals, Inc.
The Effect of Different Pollination on the Expression of Dangshan Su Pear MicroRNA

The high-throughput sequencing of pear “Dangshan Su” × “Yali” (whose fruits lignin and stone cell content are high and quality is poor) and pear “Dangshan Su” × “Wonhwang” (whose fruits with low content of lignin and stone cell and the quality are better ) found that the expressions of these two miRNAs (pyr-1809 and pyr-novel-miR-144-3p) were significantly different; their corresponding target genes encode two kinds of laccase (Pbr018935.1 and Pbr003857.1). qRT-PCR results showed that these two enzymes are involved in the formation of lignin and stone cells and the existence of these two miRNAs has a negative effect on them. It was concluded that the effect of pollination on the development of stone cells may affect the synthesis of lignin, through the regulation of laccase controlled by miRNAs, and ultimately affect the formation of stone cell and fruit quality.
Short-Text Topic Modeling via Non-negative Matrix Factorization Enriched with Local Word-Context Correlations

Being a prevalent form of social communications on the Internet, billions of short texts are generated everyday. Discovering knowledge from them has gained a lot of interest from both industry and academia. The short texts have a limited contextual information, and they are sparse, noisy and ambiguous, and hence, automatically learning topics from them remains an important challenge. To tackle this problem, in this paper, we propose a semantics-assisted non-negative matrix factorization (SeaNMF) model to discover topics for the short texts. It effectively incorporates the word-context semantic correlations into the model, where the semantic relationships between the words and their contexts are learned from the skip-gram view of the corpus. The SeaNMF model is solved using a block coordinate descent algorithm. We also develop a sparse variant of the SeaNMF model which can achieve a better model interpretability. Extensive quantitative evaluations on various real-world short text datasets demonstrate the superior performance of the proposed models over several other state-of-the-art methods in terms of topic coherence and classification accuracy. The qualitative semantic analysis demonstrates the interpretability of our models by discovering meaningful and consistent topics. With a simple formulation and the superior performance, SeaNMF can be an effective standard topic model for short texts.
Film Processability, Morphology, and Properties of Polyamide-6/Low Density Polyethylene Blends

The processing, morphology, and tensile properties of blown films prepared from polyamide-6 (PA6) and low density polyethylene (LDPE) blends with and without compatibilizer (Surlyn® 9020) are studied. The results indicate that the presence of PA6 and a compatibilizer has a great influence on blend rheology as well as mechanical and barrier properties of LDPE films where the morphology of the dispersed phase (PA6) plays an important role. In this study, film morphology is controlled mainly by variations in draw ratio and bubble pressure. It is shown that biaxial orientation of the films explains the anisotropic behavior of the mechanical properties and improved barrier properties due to the production of a lamellar structure.
Energy-efficient rate-adaptive GPS-based positioning for smartphones

Many emerging smartphone applications require position information to provide location-based or context-aware services. In these applications, GPS is often preferred over its alternatives such as GSM/WiFi based positioning systems because it is known to be more accurate. However, GPS is extremely power hungry. Hence a common approach is to periodically duty-cycle GPS. However, GPS duty-cycling trades-off positioning accuracy for lower energy. A key requirement for such applications, then, is a positioning system that provides accurate position information while spending minimal energy. In this paper, we present RAPS, rate-adaptive positioning system for smartphone applications. It is based on the observation that GPS is generally less accurate in urban areas, so it suffices to turn on GPS only as often as necessary to achieve this accuracy. RAPS uses a collection of techniques to cleverly determine when to turn on GPS. It uses the location-time history of the user to estimate user velocity and adaptively turn on GPS only if the estimated uncertainty in position exceeds the accuracy threshold. It also efficiently estimates user movement using a duty-cycled accelerometer, and utilizes Bluetooth communication to reduce position uncertainty among neighboring devices. Finally, it employs celltower-RSS blacklisting to detect GPS unavailability (e.g., indoors) and avoid turning on GPS in these cases. We evaluate RAPS through real-world experiments using a prototype implementation on a modern smartphone and show that it can increase phone lifetimes by more than a factor of 3.8 over an approach where GPS is always on.
The role of sociodemographic factors in maternal psychological distress and mother‐preterm infant interactions

Preterm birth has been associated with greater psychological distress and less positive mother infant interactions than were experienced by mothers of full-term infants. Maternal and infant sociodemographic factors have also shown a strong association with psychological distress and the mother-infant relationship. However, findings on their effects over time are limited. In this longitudinal analysis, we explored the relationship of maternal and infant sociodemographic variables (maternal age, maternal education, marital status, being on social assistance, maternal race, infant birth weight, and infant gender) to maternal psychological distress (depressive, posttraumatic stress, anxiety, parenting stress symptoms, and maternal worry about child's health) through 12 months corrected age for prematurity, and on the home environment, and mother-infant interactions through 6 months corrected age for prematurity. We also explored differences related to maternal obstetrical characteristics (gestational age at birth, parity, mode of delivery, and multiple birth) and severity of infant conditions (Apgar scores, need for mechanical ventilation, and infant medical complications). Although the relationship of maternal and infant characteristics with these outcomes did not change over time, psychological distress differed based on marital status, maternal education, infant gender, and infant medical complications. Older mothers provided more a positive home environment. Mother-infant interactions differed by maternal age, being on public assistance, maternal race, infant gender, and infant medical complications. More longitudinal research is needed to better understand these effects over time in order to identify and support at-risk mothers.
Networks underlying trait impulsivity: Evidence from voxel‐based lesion‐symptom mapping

Impulsivity is considered a multidimensional construct that encompasses a range of behaviors, including poor impulse control, premature decision‐making, and the inability to delay gratification. In order to determine the extent to which impulsivity and its components share a common network, a voxel‐based lesion‐symptom mapping (VLSM) analysis was performed in a large sample of patients (N = 131) with focal, penetrating traumatic brain injuries (pTBI). Impulsivity was assessed using the Barratt Impulsiveness Scale (BIS‐11), a standard self‐report measure that allows for unique estimates of global impulsivity and its factor analysis‐derived components (e.g., “motor impulsivity”). Heightened global impulsivity was associated with damage to multiple areas in bilateral prefrontal cortex (PFC), left superior, middle and inferior temporal gyrus, and left hippocampus. Moreover, a cluster was identified within the left PFC associated specifically with motor impulsivity (defined as “acting without thinking”). The results were consistent with the existing literature on bilateral prefrontal cortical involvement in behavioral impulsivity, but also provided new evidence for a more complex neuroanatomical representation of this construct, characterized by left‐lateralized temporal and hippocampal involvement, as well as a left‐lateralized prefrontal network specifically associated with motor impulsivity. Hum Brain Mapp 38:656–665, 2017. © 2016 Wiley Periodicals, Inc.
Residual Stresses in Multilayer Welds with Different Martensitic Transformation Temperatures Analyzed by High-Energy Synchrotron Diffraction

Low Transformation Temperature (LTT) alloys were developed in order to control the residual stress development by the martensitic phase transformation already during cooling of the weld metal. The positive effect of such LTT alloys on the mitigation of detrimental tensile residual stresses during welding has already been confirmed on the basis of individual laboratory tests. Within the current project it was experimentally investigated whether the phase transformation mechanisms are effective under increased restraint due to multi-pass welding of thicker specimens. The local residual stress depth distribution was analyzed non-destructively for V-type welds processed by arc welding using energy dispersive synchrotron X-ray diffraction (EDXRD). The use of high energy (20 keV to 150 keV) EDXRD allowed for the evaluation of diffraction spectra containing information of all contributing phases. As the investigated LTT alloy contains retained austenite after welding, this phase was also considered for stress analysis. The results show in particular how the constraining effect of increased thickness of the welded plates and additional deposited weld metal influences the level of the residual stresses in near weld surface areas. While the longitudinal residual stresses were reduced in general, in the transition zone from the weld to the heat-affected zone (HAZ) compressive residual stresses were found.
Security and Privacy Approaches in Mixed Reality

Mixed reality (MR) technology development is now gaining momentum due to advances in computer vision, sensor fusion, and realistic display technologies. With most of the research and development focused on delivering the promise of MR, the privacy and security implications of this technology are yet to be thoroughly investigated. This survey article aims to put in to light these risks and to look into the latest security and privacy work on MR. Specifically, we list and review the different protection approaches that have been proposed to ensure user and data security and privacy in MR. We extend the scope to include work on related technologies such as augmented reality, virtual reality, and human-computer interaction as crucial components, if not the origins, of MR, as well as numerous related work from the larger area of mobile devices, wearables, and Internet-of-Things. We highlight the lack of investigation, implementation, and evaluation of data protection approaches in MR. Further challenges and directions on MR security and privacy are also discussed.
Improved survival among sickle cell kidney transplant recipients in the recent era.

BACKGROUND Studies from older cohorts of kidney recipients have observed that recipients with sickle cell disease (SCD) have lower patient survival compared with age- and race-matched controls. We examined whether survival has improved among SCD recipients in the current era. METHODS Using Organ Procurement and Transplantation Network/United Network for Organ Sharing data, all black/African-American kidney recipients were stratified according to transplant year into an early (1988-99) and recent era (2000-11). Patient and allograft survival among SCD recipients and those with other diagnoses were compared (early era: SCD n = 67, others n = 20 694; recent era: SCD n = 106, others n = 34 428). A secondary-matched cohort analysis compared patient and allograft survival between SCD recipients matched to recipients with other diagnoses based on recipient and donor age, gender and donor type (deceased versus living). RESULTS Patient survival at 6 years was lower among SCD recipients in the early era compared with other diagnoses (55.7 versus 78.0%; P < 0.001). Six-year patient survival among sickle cell recipients improved in the recent era (69.8%; P versus early era = 0.04), although still trended toward lower survival compared with other diagnoses (80.0%; P = 0.07). Multivariate Cox proportional hazard models revealed an increased mortality risk with SCD in both eras [early: hazard ratio (HR) = 3.12; 95% confidence interval (CI): 2.15-4.54; recent: HR: 2.03; 95% CI: 1.31-3.16]. Patient survival among matched SCD recipients in the recent era was comparable to diabetic recipients (SCD: 73.1%, diabetes: 74.1%; P = 0.44). CONCLUSIONS Patient survival has improved among contemporary sickle cell recipients compared with an earlier cohort and is comparable to a matched cohort of diabetic kidney recipients. Appropriately selected SCD patients may receive kidney transplants with reasonable survival outcome.
Ameliorating Injury during Preservation and Isolation of Human Islets Using the Two-Layer Method with Perfluorocarbon and UW Solution

This study assessed the effects of a two-layer method (TLM), using perfluorocarbon and UW solution, on the quality of human pancreata following storage and islet yield/function after isolation. In part A, TLM was applied immediately after procurement and the energetic profile was compared to a group treated with UW solution only (control) throughout 24-h storage. In part B, cadaveric human pancreata were procured and subjected to a TLM after cold storage in UW solution (TLM group) or UW solution (control group). Energetics, lipid peroxidation, and islet recovery/function were assessed after preservation at 4°C. In part A, after 9-h storage, the energetic profile (ATP, ATP/ADP, energy charge) for the TLM group was superior to controls. In part B, TLM treatment resulted in consistently greater ATP, ATP/ADP, and energy charge values than with storage in UW solution alone (p < 0.05). UW treatment resulted in 40% greater peroxidative damage than in the TLM group (p < 0.05). Islet recovery and functional viability were 30–40% higher following TLM treatment (p < 0.05). These data support the hypothesis that islet viability and yields can be significantly improved using a brief period of TLM treatment following conventional UW storage; reduced energetic and oxidative stress are implicated as potential mechanisms.
Defending against smallpox: a focus on vaccines

ABSTRACT Smallpox has shaped human history, from the earliest human civilizations well into the 20th century. With high mortality rates, rapid transmission, and serious long-term effects on survivors, smallpox was a much-feared disease. The eradication of smallpox represents an unprecedented medical victory for the lasting benefit of human health and prosperity. Concerns remain, however, about the development and use of the smallpox virus as a biological weapon, which necessitates the need for continued vaccine development. Smallpox vaccine development is thus a much-reviewed topic of high interest. This review focuses on the current state of smallpox vaccines and their context in biodefense efforts.
Communication Efficient and Strongly Secure Secret Sharing Schemes Based on Algebraic Geometry Codes

Secret-sharing schemes with optimal and universal communication overheads have been obtained independently by Bitar <italic>et al.</italic> and Huang <italic>et al.</italic> However, their constructions require a finite field of size <inline-formula> <tex-math notation="LaTeX">$q > n$ </tex-math></inline-formula>, where <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula> is the number of shares, and do not provide strong security. In this paper, we give a general framework to construct communication efficient secret-sharing schemes based on sequences of nested linear codes, which allows to use, in particular, algebraic geometry codes and allows to obtain strongly secure and communication-efficient schemes. Using this framework, we obtain: 1) schemes with universal and close to optimal communication overheads for arbitrarily large lengths <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula> and a fixed finite field; 2) the first construction of schemes with universal and optimal communication overheads and optimal strong security (for restricted lengths), having, in particular, the component-wise security advantages of perfect schemes and the security and storage efficiency of ramp schemes; and 3) schemes with universal and close to optimal communication overheads and close to optimal strong security defined for arbitrarily large lengths <inline-formula> <tex-math notation="LaTeX">$n$ </tex-math></inline-formula> and a fixed finite field.
Shank3‐deficient rats exhibit degraded cortical responses to sound

Individuals with SHANK3 mutations have severely impaired receptive and expressive language abilities. While brain responses are known to be abnormal in these individuals, the auditory cortex response to sound has remained largely understudied. In this study, we document the auditory cortex response to speech and non‐speech sounds in the novel Shank3‐deficient rat model. We predicted that the auditory cortex response to sounds would be impaired in Shank3‐deficient rats. We found that auditory cortex responses were weaker in Shank3 heterozygous rats compared to wild‐type rats. Additionally, Shank3 heterozygous responses had less spontaneous auditory cortex firing and were unable to respond well to rapid trains of noise bursts. The rat model of the auditory impairments in SHANK3 mutation could be used to test potential rehabilitation or drug therapies to improve the communication impairments observed in individuals with Phelan‐McDermid syndrome. Autism Res 2018, 11: 59–68. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.
SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ß-catenin signaling

SOX9 inactivation is frequent in colorectal cancer (CRC) due to SOX9 gene mutations and/or to ectopic expression of MiniSOX9, a dominant negative inhibitor of SOX9. In the present study, we report a heterozygous L142P inactivating mutation of SOX9 in the DLD-1 CRC cell line and we demonstrate that the conditional expression of a wild type SOX9 in this cell line inhibits cell growth, clonal capacity and colonosphere formation while decreasing both the activity of the oncogenic Wnt/ß-catenin signaling pathway and the expression of the c-myc oncogene. This activity does not require SOX9 transcriptional function but, rather, involves an interaction of SOX9 with nuclear ß-catenin. Furthermore, we report that SOX9 inhibits tumor development when conditionally expressed in CRC cells injected either subcutaneous or intraperitoneous in BALB/c mice as an abdominal metastasis model. These observations argue in favor of a tumor suppressor activity for SOX9. As an siRNA targeting SOX9 paradoxically also inhibits DLD-1 and HCT116 CRC cell growth, we conclude that there is a critical level of endogenous active SOX9 needed to maintain CRC cell growth.