Miracle-dz/UniFAR-FTUs huggingface dataset:
Aware: Controlling App Access to I/O Devices on Mobile Platforms

Smartphones' cameras, microphones, and device displays enable users to capture and view memorable moments of their lives. However, adversaries can trick users into authorizing malicious apps that exploit weaknesses in current mobile platforms to misuse such on-board I/O devices to stealthily capture photos, videos, and screen content without the users' consent. Contemporary mobile operating systems fail to prevent such misuse of I/O devices by authorized apps due to lack of binding between users' interactions and accesses to I/O devices performed by these apps. In this paper, we propose Aware, a security framework for authorizing app requests to perform operations using I/O devices, which binds app requests with user intentions to make all uses of certain I/O devices explicit. We evaluate our defense mechanisms through laboratory-based experimentation and a user study, involving 74 human subjects, whose ability to identify undesired operations targeting I/O devices increased significantly. Without Aware, only 18% of the participants were able to identify attacks from tested RAT apps. Aware systematically blocks all the attacks in absence of user consent and supports users in identifying 82% of social-engineering attacks tested to hijack approved requests, including some more sophisticated forms of social engineering not yet present in available RATs. Aware introduces only 4.79% maximum performance overhead over operations targeting I/O devices. Aware shows that a combination of system defenses and user interface can significantly strengthen defenses for controlling the use of on-board I/O devices.
Feature Selection for MLP Neural Network: The Use of Random Permutation of Probabilistic Outputs

This paper presents a new wrapper-based feature selection method for multilayer perceptron (MLP) neural networks. It uses a feature ranking criterion to measure the importance of a feature by computing the aggregate difference, over the feature space, of the probabilistic outputs of the MLP with and without the feature. Thus, a score of importance with respect to every feature can be provided using this criterion. Based on the numerical experiments on several artificial and real-world data sets, the proposed method performs, in general, better than several selected feature selection methods for MLP, particularly when the data set is sparse or has many redundant features. In addition, as a wrapper-based approach, the computational cost for the proposed method is modest.
Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus

Background & Aims Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1. We aimed to identify further SNPs that increased BE risk and to validate previously reported associations. Methods We performed a genome-wide association study (GWAS) to identify variants associated with BE and further analyzed promising variants identified by BEACON by genotyping 10,158 patients with BE and 21,062 controls. Results We identified 2 SNPs not previously associated with BE: rs3072 (2p24.1; odds ratio [OR] = 1.14; 95% CI: 1.09–1.18; P = 1.8 × 10−11) and rs2701108 (12q24.21; OR = 0.90; 95% CI: 0.86–0.93; P = 7.5 × 10−9). The closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development. Our data also supported in BE cases 3 risk SNPs identified by BEACON (rs2687201, rs11789015, and rs10423674). Meta-analysis of all data identified another SNP associated with BE and esophageal adenocarcinoma: rs3784262, within ALDH1A2 (OR = 0.90; 95% CI: 0.87–0.93; P = 3.72 × 10−9). Conclusions We identified 2 loci associated with risk of BE and provided data to support a further locus. The genes we found to be associated with risk for BE encode transcription factors involved in thoracic, diaphragmatic, and esophageal development or proteins involved in the inflammatory response.
Design of New Power Management Circuit for Light Energy Harvesting System

Nowadays, it can be observed that Wireless Sensors Networks (WSN) are taking increasingly vital roles in many applications, such as building energy monitoring and control, which is the focus of the work in this paper. However, the main challenging issue with adopting WSN technology is the use of power sources such as batteries, which have a limited lifetime. A smart solution that could tackle this problem is using Energy Harvesting technology. The work in this paper will be focused on proposing a new power management design through harvesting indoor light intensity. The new approach is inspired by the use of the Fractional Open Circuit Voltage based Maximum Power Point tracking (MPPT) concept for sub mw Photo Voltaic (PV) cells. The new design adopts two main features: First, it minimizes the power consumed by the power management section; and second, it maximizes the MPPT-converted output voltage and consequently improves the efficiency of the power conversion in the sub mw power level. The new experimentally-tested design showed an improvement of 81% in the efficiency of MPPT conversion using 0.5 mW input power in comparison with the other presented solutions that showed less efficiency with higher input power.
Strength Degradation due to Fatigue in Fiber Dominated Glass/Epoxy Composites: A Statistical Approach

The performance of different residual strength theories for composites subjected to fatigue loading is discussed in this article. Especially, the probabilistic aspects of strength degradation predictions are emphasized, with respect to the reliability levels defined using different approaches. A statistical model, using the `Strength-Life Equal Rank Assumption' (SLERA), is introduced and is shown to yield robust and accurate reliability bounds for residual strength after fatigue; this holds true even when used in conjunction with simple degradation concepts. Theoretical predictions are corroborated satisfactorily by experimental results from a comprehensive test program on [0]4 glass/epoxy composite laminates used in manufacturing of large, contemporary wind turbine rotor blades. It is shown that the use of complicated strength degradation theories requiring large experimental data sets for implementation, yields more accurate predictions than simple models requiring limited experimental effort. Nevertheless, the linear strength degradation model by Broutman and Sahu [1] performs satisfactorily, offering consistent predictions on the safe side and constitutes a strong candidate for engineering design applications.
Sorption and degradation of estrogen‐like‐endocrine disrupting chemicals in soil

Studies were undertaken to assess sorption of seven endocrine‐disrupting chemicals (EDCs), namely, estrone (E1), 17β‐estradiol (E2), estriol (E3), 17α‐ethynylestradiol (EE2), bisphenol A (BPA), 4‐tert‐octyl phenol (4‐t‐OP), and 4‐n‐nonyl phenol (4‐n‐NP) on four soils (from sandy to clay soil) with different physicochemical properties and biodegradation of five EDCs (BPA, E2, EE2, 4‐t‐OP, and 4‐n‐NP) in a loam soil associated with wastewater reuse. We also characterized the biotransformation of E2 to E1 in the loam soil under aerobic and anaerobic conditions. Sorption test using a batch equilibrium method demonstrated that alkylphenols (4‐t‐OP and 4‐n‐NP) had the strongest sorption onto soils, followed by estrogens (EE2, E2, E1, E3) and BPA. This laboratory study showed that all five EDCs, including the degradation product E1, were degraded rapidly in the soil within 7 d under aerobic conditions. However, under anaerobic conditions in the soil, little or no degradation of the five EDCs was noted except for E2, which showed slow degradation during the 70‐d study. The calculated half‐lives for E2 under anaerobic conditions were 24 d in the soil. Estradiol was found to be biotransformed to E1 under both aerobic and anaerobic conditions. The study suggested that the five EDCs as well as E1, which may be present in reclaimed wastewater, would not persist in well‐aerated soil. But these EDCs persisting in anaerobic soil may affect soil and groundwater quality and ecosystem.
The Price of a Neglected Zoonosis: Case-Control Study to Estimate Healthcare Utilization Costs of Human Brucellosis

Human brucellosis has reemerged as a serious public health threat to the Bedouin population of southern Israel in recent years. Little is known about its economic implications derived from elevated healthcare utilization (HCU). Our objective was to estimate the HCU costs associated with human brucellosis from the insurer perspective. A case-control retrospective study was conducted among Clalit Health Services (CHS) enrollees. Brucellosis cases were defined as individuals that were diagnosed with brucellosis at the Clinical Microbiology Laboratory of Soroka University Medical Center in the 2010–2012 period (n = 470). Control subjects were randomly selected and matched 1:3 by age, sex, clinic, and primary physician (n = 1,410). HCU data, demographic characteristics and comorbidities were obtained from CHS computerized database. Mean±SD age of the brucellosis cases was 26.6±17.6 years. 63% were male and 85% were Bedouins. No significant difference in Charlson comorbidity index was found between brucellosis cases and controls (0.41 vs. 0.45, respectively, P = 0.391). Before diagnosis (baseline), the average total annual HCU cost of brucellosis cases was slightly yet significantly higher than that of the control group ($439 vs. $382, P<0.05), however, no significant differences were found at baseline in the predominant components of HCU, i.e. hospitalizations, diagnostic procedures, and medications. At the year following diagnosis, the average total annual HCU costs of brucellosis cases was significantly higher than that of controls ($1,327 vs. $380, respectively, P<0.001). Most of the difference stems from 7.9 times higher hospitalization costs (p<0.001). Additional elevated costs were 3.6 times higher laboratory tests (P<0.001), 2.8 times higher emergency room visits (P<0.001), 1.8 times higher medication (P<0.001) and 1.3 times higher diagnostic procedures (P<0.001). We conclude that human brucellosis is associated with elevated HCU costs. Considering these results in cost-effective analyses may be crucial for both reducing health inequities and optimal allocation of health systems’ scarce resources.
Contribution of the CR Domain to P-Selectin Lectin Domain Allostery by Regulating the Orientation of the EGF Domain

The allostery of P-selectin has been studied extensively with a focus on the Lec and EGF domains, whereas the contribution of the CR domain remains unclear. Here, molecular dynamics simulations (MDS) combined with homology modeling were preformed to investigate the impact of the CR domain on P-selectin allostery. The results indicated that the CR domain plays a role in the allosteric dynamics of P-selectin in two ways. First, the CR1 domain tends to stabilize the low affinity of P-selectin during the equilibration processes with the transition inhibition from the S1 to S1’ state by restraining the extension of the bent EGF orientation, or with the relaxation acceleration of the S2 state by promoting the bending of the extended EGF orientation. Second, the existence of CR domain increases intramolecular extension prior to complex separation, increasing the time available for the allosteric shift during forced dissociation with a prolonged bond duration. These findings further our understanding of the structure-function relationship of P-selectin with the enriched micro-structural bases of the CR domain.
The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis

ABSTRACT Background – The presence of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment is associated with an improved prognosis and a better response to therapy in different types of cancer. In this systematic review and meta-analysis, we investigated the prognostic value of T cells in head and neck squamous cell carcinoma (HNSCC). Methods – In a systematic review, Pubmed and Embase were searched for publications that investigated the prognostic value of T cells in HNSCC. A meta-analysis was performed including all studies assessing the association between CD3+, CD4+, CD8+, and FoxP3+ TILs and overall survival (OS), disease-free survival (DFS), or locoregional control (LRC). Results – A pooled analysis indicated a favorable, prognostic role for CD3+ TILs (HR 0.64 (95%CI 0.47–0.85) for OS, HR 0.63 (95%CI 0.49–0.82) for DFS) and CD8+ TILs (HR 0.67 (95%CI 0.58–0.79) for OS, HR 0.50 (95%CI 0.37–0.68) for DFS, and HR 0.82 (95%CI 0.70–0.96) for LRC) in the clinical outcome of HNSCC. FoxP3+ TILs were also associated with better OS (HR 0.80 (95%CI 0.70–0.92)). Conclusion – This systematic review and meta-analysis confirmed the favorable, prognostic role of CD3+ and CD8+ T cell infiltration in HNSCC patients and found an association between FoxP3+ TILs and improved overall survival. Future studies using homogeneous patient cohorts with regard to tumor subsite, stage and treatment are necessary to provide more insight in the predictive value of TILs in HNSCC.
Can Decentralized Algorithms Outperform Centralized Algorithms? A Case Study for Decentralized Parallel Stochastic Gradient Descent

Most distributed machine learning systems nowadays, including TensorFlow and CNTK, are built in a centralized fashion. One bottleneck of centralized algorithms lies on high communication cost on the central node. Motivated by this, we ask, can decentralized algorithms be faster than its centralized counterpart? Although decentralized PSGD (D-PSGD) algorithms have been studied by the control community, existing analysis and theory do not show any advantage over centralized PSGD (C-PSGD) algorithms, simply assuming the application scenario where only the decentralized network is available. In this paper, we study a D-PSGD algorithm and provide the first theoretical analysis that indicates a regime in which decentralized algorithms might outperform centralized algorithms for distributed stochastic gradient descent. This is because D-PSGD has comparable total computational complexities to C-PSGD but requires much less communication cost on the busiest node. We further conduct an empirical study to validate our theoretical analysis across multiple frameworks (CNTK and Torch), different network configurations, and computation platforms up to 112 GPUs. On network configurations with low bandwidth or high latency, D-PSGD can be up to one order of magnitude faster than its well-optimized centralized counterparts.
Disentangling Biodiversity and Climatic Determinants of Wood Production

Background Despite empirical support for an increase in ecosystem productivity with species diversity in synthetic systems, there is ample evidence that this relationship is dependent on environmental characteristics, especially in structurally more complex natural systems. Empirical support for this relationship in forests is urgently needed, as these ecosystems play an important role in carbon sequestration. Methodology/Principal Findings We tested whether tree wood production is positively related to tree species richness while controlling for climatic factors, by analyzing 55265 forest inventory plots in 11 forest types across five European countries. On average, wood production was 24% higher in mixed than in monospecific forests. Taken alone, wood production was enhanced with increasing tree species richness in almost all forest types. In some forests, wood production was also greater with increasing numbers of tree types. Structural Equation Modeling indicated that the increase in wood production with tree species richness was largely mediated by a positive association between stand basal area and tree species richness. Mean annual temperature and mean annual precipitation affected wood production and species richness directly. However, the direction and magnitude of the influence of climatic variables on wood production and species richness was not consistent, and vary dependent on forest type. Conclusions Our analysis is the first to find a local scale positive relationship between tree species richness and tree wood production occurring across a continent. Our results strongly support incorporating the role of biodiversity in management and policy plans for forest carbon sequestration.
Patterns of shortening and thickening of the human diaphragm.

To study how the human diaphragm changes configuration during inspiration, we simultaneously measured diaphragm thickening using ultrasound and inspired volumes using a pneumotachograph. Diaphragm length was assessed by chest radiography. We found that thickening and shortening were greatest during a breath taken primarily with the abdomen. However, the degree of thickening was greater than expected for fiber shortening, assuming parallel muscle fibers and no shear. So, to clarify this unexpected finding, we considered geometric models of the diaphragm. How a muscle thickens as its fibers shorten is critically dependent on geometry. Thus, if a flat rectangular sheet of muscle shortens along one dimension, surface area-to-length ratio along this dimension should remain constant, and thickness would be inversely proportional to length during shortening. The simplest model of the diaphragm, however, is a cylindrical sheet of muscle in the zone of apposition capped by a dome; the ratio of surface area to radial fiber length in the dome is substantially less than the ratio of area to length of the cylindrical zone of apposition; hence, as the zone of apposition shortens while the dome radius remains constant, the ratio of total surface area to combined length (i.e., dome + zone of apposition) must decrease and thickening of the muscle correspondingly must increase more than expected for a simple rectangular strip. A similar relationship can be derived between thickening and length in a muscle sheet with a wedge-shaped insertion into a thin flat tendon. Comparison of calculations with these types of models to data from human subjects indicates that the unexpected thickening in the zone of apposition is explained by the peculiar geometry of the diaphragm. The greater thickening of the diaphragm in the zone of apposition suggests that more of the muscle mass and more sarcomeres are retained in the zone of apposition as the dome descends. Physiologically, this greater thickening may have importance by reducing wall stress in the zone of apposition and reducing the work or energy requirements per sarcomere.
Data-oriented parsing and the Penn Chinese treebank

We present an investigation into parsing the Penn Chinese Treebank using a Data-Oriented Parsing (DOP) approach. DOP comprises an experience-based approach to natural language parsing. Most published research in the DOP framework uses PStrees as its representation schema. Drawbacks of the DOP approach centre around issues of efficiency. We incorporate recent advances in DOP parsing techniques into a novel DOP parser which generates a compact representation of all subtrees which can be derived from any full parse tree. We compare our work to previous work on parsing the Penn Chinese Treebank, and provide both a quantitative and qualitative evaluation. While our results in terms of Precision and Recall are slightly below those published in related research, our approach requires no manual encoding of head rules, nor is a development phase per se necessary. We also note that certain constructions which were problematic in this previous work can be handled correctly by our DOP parser. Finally, we observe that the ‘DOP Hypothesis’ is confirmed for parsing the Penn Chinese Treebank.
Comparative signal intensity measurements in dynamic gadolinium‐enhanced MR mammography

Increases in signal intensity enhancement were measured in defined regions of interest (ROIs) to allow distinction between malignant and benign tumors with dynamic gadolinium‐enhanced magnetic resonance (MR) mammography. Twenty patients with palpable breast lesions (15 malignant, five benign) underwent MR mammography. The dynamic gradient‐echo sequence was performed with intravenous bolus injection of gadopentetate dimeglumine and consisted of 25 images with a time resolution of 30 seconds. Contrast enhancement was calculated by comparing user‐defined ROIs on pre‐ and postcontrast images. An increase in signal intensity of 70% or more on the 1‐minute postcontrast image was used as the criterion of malignancy. MR mammographic results correlated with histopathologic findings in all patients when the defined ROI was in the most enhancing part of the tumor. For the ROI in areas of submaximal enhancement or when the ROI surrounded the whole lesion, only five and nine tumors, respectively, fulfilled the malignancy criterion. All malignant tumors showed large variations in signal intensity enhancement that depended on the position of the ROI in the tumor. Dynamic, gadolinium‐enhanced MR mammography allows distinction of benign from malignant breast tumors when the selected ROI is in the most enhancing part of the lesion.
An analysis of voice over Internet Protocol in wireless mesh networks

The paper focuses on analyzing the affects of wireless mesh networks with some mobile nodes on Voice over Internet Protocol service quality. Our interest is to examine this in simulation to learn how to better deploy voice services on such a network in a rural community. Wireless mesh networks' unique characteristics like multi-hop, node mobility, coverage, and medium usage cause quality of service issues for Voice over Internet Protocol implementations. This research considers three wireless mesh scenarios on 26 mesh nodes. In the first scenario all nodes are stationary. In the second, 10 nodes are mobile and 16 nodes are stationary. In a third scenario, all nodes are mobile. Nodes move at a walking speed of 1.3m per second. The analysis and results show that while node mobility can increase packet loss, delay, jitter, Voice over Internet Protocol implementations in wireless mesh networks can be successful if there is no background traffic. We recommend that Voice over Internet Protocol implementations in wireless mesh networks with some mobile nodes and background traffic be supported by quality of service standards; else it can lead to service level delivery failures.