Miracle-dz/UniFAR-FTUs huggingface dataset:
Salicylic acid and antitranspirant polymer mitigate the effects of water stress on the growth and yield of cowpea

Water stress can limit the growth and production of cowpea (Vigna unguiculata (L.) Walp. ), necessitating the use of strategies that induce plant tolerance to mitigate its effects on the crop. This includes the application of salicylic acid (SA) and antitranspirant polymer (AP). The objective of this study was to evaluate the effect of SA and AP applications on the growth and production of cowpeas subjected to water stress. The experiment was conducted in field conditions at Sítio Boqueirão, Catolé do Rocha, Paraíba, Brazil. The experimental design used was randomized blocks, comprising 10 treatments with four replications. The evaluated treatments included nine combinations generated according to the Central Composite Design experimental matrix, involving five doses of SA and five doses of AP applied to plants under water stress, along with an additional treatment (without water stress and application of SA and AP). The assessed variables included morphological parameters and yield. The data were subjected to canonical correspondence analysis and confidence ellipses. The application of SA and AP increased growth (summer and spring) and productivity (summer). However, in spring, there was a decrease in productivity and an increase in the number of days until the initiation of pod harvesting in cowpeas under water stress.
Dynamic congruence vs. progressing bisimulation for CCS

Weak Observational Congruence (woc) defined on CCS agents is not a bisimulation since it does not require two states reached by bisimilar computations of woc agents to be still woc, e.g. \alpha. \tau. \beta.nil and \alpha. \beta.nil are woc but \tau. \beta.nil and \beta.nil are not. This fact prevent us from characterizing CCS semantics (when \tau is considered invisible) as a final algebra, since the semantic function would induce an equivalence over the agents that is both a congruence and a bisimulation. In the paper we introduce a new behavioural equivalence for CCS agents, which is the coarsest among those bisimulations which are also congruences. We call it Dynamic Observational Congruence because it expresses a natural notion of equivalence for concurrent systems required to simulate each other in the presence of dynamic, i.e. run time, (re)configurations. We provide an algebraic characterization of Dynamic Congruence in terms of a universal property of finality. Furthermore we introduce Progressing Bisimulation, which forces processes to simulate each other performing explicit steps. We provide an algebraic characterization of it in terms of finality, two logical characterizations via modal logic in the style of HML and a complete axiomatization for finite agents (consisting of the axioms for Strong Observational Congruence and of two of the three Milner's $\tau$-laws). Finally, we prove that Dynamic Congruence and Progressing Bisimulation coincide for CCS agents.
Fuzzy Enhanced Control of an Underactuated Finger Using Tactile and Position Sensors

This paper proposes a control scheme dedicated to underactuated fingers with the intention of maximizing the capabilities of the latter using tactile and position information at a minimum cost. Tactile sensors are implemented on one prototype of underactuated finger and used to enhance the behaviour of the hand despite its limited number of control signals. First, tactile technology is briefly recalled and discussed. Second, the electronic design of the sensors' controller is presented. Third, a real-time control scheme is introduced, based on a fuzzy force control method. Finally, a slippage prevention technique is presented. Results are discussed based on experimental observations and indicate that the behaviour of underactuated fingers can be substantially enhanced with tactile information and a classic fuzzy control approach.
Which Patient and Clinician Characteristics Are Associated With High-Quality Communication Among Veterans With Chronic Obstructive Pulmonary Disease?

The authors evaluated associations of patient and clinician characteristics with high-quality communication among patients with chronic obstructive pulmonary disease. Using a cross-sectional analysis from patients with chronic obstructive pulmonary disease enrolled in a clinical trial, the authors evaluated the association of patient and clinician characteristics with patient-reported communication quality. The authors measured these associations using general estimating equations and adjusted odds ratios for best imagined communication quality. Most patient and clinician characteristics, including age, race/ethnicity, mental health attributes, and clinician specialty, were not associated with communication quality. Patient-reported clinician expertise (OR = 2.10, 95% CI [1.52, 2.88], p < .001) was associated with increased communication quality, while the patient not being married was associated with decreased quality (OR = 0.52, 95% CI [0.27, 0.99], p = .047). Only one modifiable characteristic, patient-reported clinician expertise, was associated with best imagined communication quality. This characteristic may be important to include as a potential intermediate outcome in future communication intervention studies. Predictors and outcomes of communication quality are not uniform across patient populations and settings. To maximize the effectiveness of communication interventions, it is important to have a thorough understanding of which patient, clinician, and system factors are associated with communication quality.
AmpC β-lactamases in nosocomial isolates of Klebsiella pneumoniae from India

Background & objectives: AmpC β-lactamases are clinically significant since these confer resistance to cephalosporins in the oxyimino group, 7-α methoxycephalosporins and are not affected by available β-lactamase inhibitors. In this study we looked for both extended spectrum β-lactamases (ESBL) and AmpC β-lactamases in Klebsiella pneumoniae clinical isolates. Methods: One hundred consecutive, non-duplicate clinical isolates of K. pneumoniae collected over a period of one year (June 2008 - June 2009) were included in the study. An antibiotic susceptibility method was used with 10 antibiotics for Gram-negative infections which helped in screening for ESBL and AmpC β-lactamases and also in confirmation of ESBL production. The detection of AmpC β-lactamases was done based on screening and confirmatory tests. For screening, disc diffusion zones of cefoxitin <18 mm was taken as cefoxitin resistant. All cefoxitin resistant isolates were tested further by AmpC disk test and modified three dimensional test. Multiplex-PCR was performed for screening the presence of plasmid-mediated AmpC genes. Results: Of the 100 isolates of K. pneumoniae studied, 48 were resistant to cefoxitin on screening. AmpC disk test was positive in 32 (32%) isolates. This was also confirmed with modified three dimensional test. Indentation indicating strong AmpC producer was observed in 25 isolates whereas little distortion (weak AmpC) was observed in 7 isolates. ESBL detection was confirmed by a modification of double disk synergy test in 56 isolates. Cefepime was the best cephalosporin in synergy with tazobactam for detecting ESBL production in isolates co-producing AmpC β-lactamases. The subsets of isolates phenotypically AmpC β-lactamase positive were subjected to amplification of six different families of AmpC gene using multiplex PCR. The sequence analysis revealed 12 CMY-2 and eight DHA-1 types. Interpretation & conclusions: Tazobactam was the best β-lactamase inhibitor for detecting ESBL in presence of AmpC β-lactamase as this is a very poor inducer of AmpC gene. Amongst cephalosporins, cefepime was the best cephalosporin in detecting ESBL in presence of AmpC β-lactamase as it is least hydrolyzed by AmpC enzymes. Cefepime-tazobactam combination disk test would be a simple and best method in detection of ESBLs in Enterobacteriaceae co-producing AmpC β-lactamase in the routine diagnostic microbiology laboratories.
Predicting Different Conceptualizations of System Use: The Competing Roles of Behavioral Intention, Facilitating Conditions, and Behavioral Expectation

Employees' underutilization of new information systems undermines organizations' efforts to gain benefits from such systems. The two main predictors of individual-level system use in prior research-behavioral intention and facilitating conditions-have limitations that we discuss. We introduce behavioral expectation as a predictor that addresses some of the key limitations and provides a better understanding of system use. System use is examined in terms of three key conceptualizations: duration, frequency, and intensity. We develop a model that employs behavioral intention, facilitating conditions, and behavioral expectation as predictors of the three conceptualizations of system use. We argue that each of these three determinants play different roles in predicting each of the three conceptualizations of system use. We test the proposed model in the context of a longitudinal field study of 321 users of a new information system. The model explains 65 percent, 60 percent, and 60 percent of the variance in duration, frequency, and intensity of system use respectively. We offer theoretical and practical implications for our findings.
Photovoltaic Sample-and-Hold Circuit Enabling MPPT Indoors for Low-Power Systems

Photovoltaic (PV) energy harvesting is commonly used to power autonomous devices, and maximum power point tracking (MPPT) is often used to optimize its efficiency. This paper describes an ultra low-power MPPT circuit with a novel sample-and-hold and cold-start arrangement, enabling MPPT across the range of light intensities found indoors, which has not been reported before. The circuit has been validated in practice and found to cold-start and operate from 100 lux (typical of dim indoor lighting) up to 5000 lux with a 55 cm2 amorphous silicon PV module. It is more efficient than non-MPPT circuits, which are the state-of-the-art for indoor PV systems. The proposed circuit maximizes the active time of the PV module by carrying out samples only once per minute. The MPPT control arrangement draws a quiescent current draw of only 8 μA, and does not require an additional light sensor as has been required by previously reported low-power MPPT circuits.
Barriers to Accessing and Engaging in HIV Preventive Care and Pre-Exposure Prophylaxis Experienced by Transgender Women in Florida

Background: PrEP, a biomedical HIV prevention option, continues to be underutilized among transgender women who could benefit from sustained use, especially women of color and those who identify as Latina and/or reside in the southeastern US. Objective: We explored the barriers and facilitators experienced by transgender women who live in Florida regarding accessing, using, and/or staying on PrEP. Methods: In-depth interviews and focus groups were conducted in either Spanish or English with adult transgender women living in Florida (N = 22). The interviews were audio-recorded, transcribed, and coded in ATLAS.ti using thematic analyses. Results: The mean age of the participants was 42.2 years. Among the participants, 73% were Hispanic/Latina, 59% were foreign-born, and approximately one-third were living with HIV (but had past experience with PrEP). Transgender women cited the following barriers to accessing or considering PrEP: (1) costs and benefits of PrEP use; (2) under-representation in clinical trials resulting in unknown or misinformation regarding PrEP side effects; (3) chronic poverty; and (4) trauma and discrimination. Other stressors, such as behavioral healthcare needs, were identified. Conclusions: Our analysis revealed interlocking systems of oppression like transphobia, discrimination, and misgendering, which were common barriers experienced by our participants. These synergistically epidemic (i.e., syndemic) barriers contributed to their feelings of being systematically excluded in social spaces, research, public health planning and policies, laws, and social programs related to PrEP. These structural barriers are impediments to HIV preventive care but also act as a source of stress that contributes to mental health problems, financial vulnerability, substance abuse, and other deleterious health outcomes.
The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric Oncology Group experience.

The State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14222, and the Roswell Park Cancer Institute, Buffalo, NY 14263 [P.K. D. , M.E. C. ]; Baylor College of Medicine, Houston, TX 77030 [M.E. H. ]; H. Lee Moftt Cancer Center, Tampa, FL 33612 [J.P.K. ]; The Johns Hopkins Hospital, Baltimore, MD 21287 [P.C. B. ]; St. Jude Children’s Research Hospital, Memphis, TN 38101 [R.A. S. , L.E. K. ]; Duke University Medical Center, Durham, NC 27710 [H.S. F. ]; and the Pediatric Oncology Group, Chicago, IL 60611
Whole chromosome painting of B chromosomes of the red-eye tetra Moenkhausia sanctaefilomenae (Teleostei, Characidae)

Abstract B chromosomes are dispensable genomic elements found in different groups of animals and plants. In the present study, a whole chromosome probe was generated from a specific heterochromatic B chromosome occurring in cells of the characidae fish Moenkhausia sanctaefilomenae (Steindachner, 1907). The chromosome painting probes were used in fluorescence in situ hybridization (FISH) experiments for the assessment of metaphase chromosomes obtained from individuals from three populations of Moenkhausia sanctaefilomenae. The results revealed that DNA sequences were shared between a specific B chromosome and many chromosomes of the A complement in all populations analyzed, suggesting a possible intra-specific origin of these B chromosomes. However, no hybridization signals were observed in other B chromosomes found in the same individuals, implying a possible independent origin of B chromosome variants in this species. FISH experiments using 18S rDNA probes revealed the presence of non-active ribosomal genes in some B chromosomes and in some chromosomes of the A complement, suggesting that at least two types of B chromosomes had an independent origin. The role of heterochromatic segments and ribosomal sequences in the origin of B chromosomes were discussed.
Induction of MicroRNA-1 by Myocardin in Smooth Muscle Cells Inhibits Cell Proliferation

Objective—Myocardin is a cardiac- and smooth muscle-specific transcription co-factor that potently activates the expression of downstream target genes. Previously, we demonstrated that overexpression of myocardin inhibited the proliferation of smooth muscle cells (SMCs). Recently, myocardin was reported to induce the expression of microRNA-1 (miR-1) in cardiomyocytes. In this study, we investigated whether myocardin induces miR-1 expression to mediate its inhibitory effects on SMC proliferation. Methods and Results—Using tetracycline-regulated expression (T-REx) inducible system expressing myocardin in human vascular SMCs, we found that overexpression of myocardin resulted in significant induction of miR-1 expression and inhibition of SMC proliferation, which was reversed by miR-1 inhibitors. Consistently, introduction of miR-1 into SMCs inhibited their proliferation. We isolated spindle-shaped and epithelioid human SMCs and demonstrated that spindle-shaped SMCs were more differentiated and less proliferative. Correspondingly, spindle-shaped SMCs had significantly higher expression levels of both myocardin and miR-1 than epithelioid SMCs. We identified Pim-1, a serine/threonine kinase, as a target gene for miR-1 in SMCs. Western blot and luciferase reporter assays further confirmed that miR-1 targeted Pim-1 directly. Furthermore, neointimal lesions of mouse carotid arteries displayed downregulation of myocardin and miR-1 with upregulation of Pim-1. Conclusion—Our data demonstrate that miR-1 participates in myocardin-dependent of SMC proliferation inhibition.
Relations between Perceptual and Physiological Response during Incremental Exercise Followed by an Extended Bout of Submaximal Exercise on a Cycle Ergometer

The purpose of this study was to examine the relations of ratings of perceived exertion (RPE) of the legs, chest, and overall body with physiological responses (heart rate and oxygen uptake) both during incremental cycling exercise and the recovery stage (submaximal light exercise after total exhaustion). Subjects were 10 healthy university males ages 18 to 23 years (M age = 20.5 yr., SD= 1.4 yr.) who performed incremental cycling exercise until exhaustion after 1-min. rest and unloaded cycling for 2 min. They then continued to exercise at a constant load of 30 Watts (used for cooling down; recovery stage) for a total of 25 min. Oxygen uptake and heart rate were measured, and three types of RPE were done; Respiratory (chest; RPE-R), Peripheral (legs; RPE-P), and Overall (overall body; RPE-O) during the exercise and recovery stage. All variables during exercise and RPE-R and RPE-P during recovery stage showed significant linear changes. RPE-O and physiological exercise intensity (oxygen uptake and heart rate) in the recovery stage showed significant curvilinear changes (quadratic). RPE-P were significantly higher than RPE-R both during exercise and the recovery stage and the variables highly correlated (r ≥.88, p <.05). At the point of exhaustion, RPE-P and RPE-O almost reached a peak, but RPE-R did not. In the exercise period until exhaustion, the regression coefficient of RPE-R (.38) was significantly lower than that of RPE-P (.56) and RPE-O (.50), and RPE-R increased according to an increase of the incremental load, but the amount was significantly lower than those of RPE-P and RPE-O. In the recovery stage after exhaustion, the regression coefficient of RPE-O (−1.35) was significantly greater than that of RPE-P (−1.07). A decrease in RPE-O corresponded to a decrease in heart rate and oxygen uptake, but RPE-P did not, and the recovery of RPE-P tended to be late. The results suggest that relations for the physiological responses of heart rate, oxygen uptake, and RPE, and between each RPE in the recovery stage differed from those during exercise until exhaustion.
Global Gene Expression and Focused Knockout Analysis Reveals Genes Associated with Fungal Fruiting Body Development in Neurospora crassa

ABSTRACT Fungi can serve as highly tractable models for understanding genetic basis of sexual development in multicellular organisms. Applying a reverse-genetic approach to advance such a model, we used random and multitargeted primers to assay gene expression across perithecial development in Neurospora crassa. We found that functionally unclassified proteins accounted for most upregulated genes, whereas downregulated genes were enriched for diverse functions. Moreover, genes associated with developmental traits exhibited stage-specific peaks of expression. Expression increased significantly across sexual development for mating type gene mat a-1 and for mat A-1 specific pheromone precursor ccg-4. In addition, expression of a gene encoding a protein similar to zinc finger, stc1, was highly upregulated early in perithecial development, and a strain with a knockout of this gene exhibited arrest at the same developmental stage. A similar expression pattern was observed for genes in RNA silencing and signaling pathways, and strains with knockouts of these genes were also arrested at stages of perithecial development that paralleled their peak in expression. The observed stage specificity allowed us to correlate expression upregulation and developmental progression and to identify regulators of sexual development. Bayesian networks inferred from our expression data revealed previously known and new putative interactions between RNA silencing genes and pathways. Overall, our analysis provides a fine-scale transcriptomic landscape and novel inferences regarding the control of the multistage development process of sexual crossing and fruiting body development in N. crassa.
Physician wages across specialties: informing the physician reimbursement debate.

BACKGROUND Disparities in remuneration between primary care and other physician specialties may impede health care reform by undermining the sustainability of a primary care workforce. Previous studies have compared annual incomes across specialties unadjusted for work hours. Wage (earnings-per-hour) comparisons could better inform the physician payment debate. METHODS In a cross-sectional analysis of data from 6381 physicians providing patient care in the 2004-2005 Community Tracking Study (adjusted response rate, 53%), we compared wages across broad and narrow categories of physician specialties. Tobit and linear regressions were run. Four broad specialty categories (primary care, surgery, internal medicine and pediatric subspecialties, and other) and 41 specific specialties were analyzed together with demographic, geographic, and market variables. RESULTS In adjusted analyses on broad categories, wages for surgery, internal medicine and pediatric subspecialties, and other specialties were 48%, 36%, and 45% higher, respectively, than for primary care specialties. In adjusted analyses for 41 specific specialties, wages were significantly lower for the following than for the reference group of general surgery (wage near median, $85.98): internal medicine and pediatrics combined (-$24.36), internal medicine (-$24.27), family medicine (-$23.70), and other pediatric subspecialties (-$23.44). Wage rankings were largely impervious to adjustment for control variables, including age, race, sex, and region. CONCLUSIONS Wages varied substantially across physician specialties and were lowest for primary care specialties. The primary care wage gap was likely conservative owing to exclusion of radiologists, anesthesiologists, and pathologists. In light of low and declining medical student interest in primary care, these findings suggest the need for payment reform aimed at increasing incomes or reducing work hours for primary care physicians.
Plasma 25-Hydroxyvitamin D Levels and the Risk of Colorectal Cancer: The Multiethnic Cohort Study

Vitamin D is obtained from the diet and synthesized in skin exposed to sunlight. Vitamin D status, assessed by circulating 25-hydroxyvitamin D [25(OH)D], has been associated with a reduced risk of colorectal cancer in previous studies. To complement existing evidence, we conducted a case-control study nested within the Multiethnic Cohort including men and women of Japanese, Latino, African-American, White, and Native Hawaiian ancestry. Using a direct competitive chemiluminescence immunoassay, 25(OH)D level was determined in plasma drawn before diagnosis from 229 cases and 434 controls matched to cases by area (Hawaii, Los Angeles), sex, ethnicity, birth year, blood draw date and time, and hours fasting. Odds ratios (OR) were estimated with conditional logistic regression. An inverse trend was observed (OR per doubling of 25(OH)D, 0.68; 95% confidence interval, 0.51-0.92; P = 0.01), but when examined in categories, relative to the first quintile (<16.8 ng/mL), the ORs in all other quintiles were quite similarly reduced between 37% and 46%. The association was not significantly heterogeneous among the four largest ethnic groups (Pheterogeneity = 0.46). In summary, this study provides evidence of an association between vitamin D status and reduced risk of colorectal cancer in an ethnically diverse population. Cancer Epidemiol Biomarkers Prev; 19(1); 130–4