Miracle-dz/UniFAR-FTUs huggingface dataset:
Social network analysis and mining to support the assessment of on-line student participation

There is a growing number of courses delivered using elearning environments and their online discussions play an important role in collaborative learning of students. Even in courses with a few number of students, there could be thousands of messages generated in a few months within these forums. Manually evaluating the participation of students in such case is a significant challenge, considering the fact that current e-learning environments do not provide much information regarding the structure of interactions between students. There is a recent line of research on applying social network analysis (SNA) techniques to study these interactions. Here we propose to exploit SNA techniques, including community mining, in order to discover relevant structures in social networks we generate from student communications but also information networks we produce from the content of the exchanged messages. With visualization of these discovered relevant structures and the automated identification of central and peripheral participants, an instructor is provided with better means to assess participation in the online discussions. We implemented these new ideas in a toolbox, named Meerkat-ED, which automatically discovers relevant network structures, visualizes overall snapshots of interactions between the participants in the discussion forums, and outlines the leader/peripheral students. Moreover, it creates a hierarchical summarization of the discussed topics, which gives the instructor a quick view of what is under discussion. We believe exploiting the mining abilities of this toolbox would facilitate fair evaluation of students' participation in online courses.
Liposome bupivacaine for improvement in economic outcomes and opioid burden in GI surgery: IMPROVE Study pooled analysis

Postsurgical pain management remains a significant challenge. Liposome bupivacaine, as part of a multimodal analgesic regimen, has been shown to significantly reduce postsurgical opioid consumption, hospital length of stay (LOS), and hospitalization costs in gastrointestinal (GI) surgery, compared with intravenous (IV) opioid-based patient-controlled analgesia (PCA). Pooled results from open-label studies comparing a liposome bupivacaine-based multimodal analgesic regimen with IV opioid PCA were analyzed. Patients (n=191) who underwent planned surgery and received study drug (IV opioid PCA, n=105; multimodal analgesia, n=86) were included. Liposome bupivacaine-based multimodal analgesia compared with IV opioid PCA significantly reduced mean (standard deviation [SD]) postsurgical opioid consumption (38 [55] mg versus [vs] 96 [85] mg; P<0.0001), postsurgical LOS (median 2.9 vs 4.3 days; P<0.0001), and mean hospitalization costs (US$8,271 vs US$10,726; P=0.0109). The multimodal analgesia group reported significantly fewer patients with opioid-related adverse events (AEs) than the IV opioid PCA group (P=0.0027); there were no significant between-group differences in patient satisfaction scores at 30 days. A liposome bupivacaine-based multimodal analgesic regimen was associated with significantly less opioid consumption, opioid-related AEs, and better health economic outcomes compared with an IV opioid PCA-based regimen in patients undergoing GI surgery. Study registration This pooled analysis is based on data from Phase IV clinical trials registered on the US National Institutes of Health www.ClinicalTrials. gov database under study identifiers NCT01460485, NCT01507220, NCT01507233, NCT01509638, NCT01509807, NCT01509820, NCT01461122, NCT01461135, NCT01534988, and NCT01507246.
Invariant differential operators for quantum symmetric spaces, II

This is the first paper in a series of two which proves a version of a theorem of Harish-Chandra for quantum symmetric spaces in the maximally split case: There is a Harish-Chandra map which induces an isomorphism between the ring of quantum invariant differential operators and the ring of invariants of a certain Laurent polynomial ring under an action of the restricted Weyl group. Here, we establish this result for all quantum symmetric spaces defined using irreducible symmetric pairs not of type EIII, EIV, EVII, or EIX. A quantum version of a related theorem due to Helgason is also obtained: The image of the center under this Harish-Chandra map is the entire invariant ring if and only if the underlying irreducible symmetric pair is not one of these four types.
Usefulness of a selective neutrophil elastase inhibitor, sivelestat, in acute lung injury patients with sepsis

Background Neutrophil elastase plays a crucial role in the development of acute lung injury (ALI) in patients with systemic inflammatory response syndrome (SIRS). The clinical efficacy of the neutrophil elastase inhibitor, sivelestat, for patients with ALI associated with SIRS has not been convincingly demonstrated. The aim of this study was to determine if there are clinical features of patients with this condition that affect the efficacy of sivelestat. Methods This was a retrospective study of 110 ALI patients with SIRS. Clinical information, including the etiology of ALI, the number of organs failing, scoring systems for assessing the severity of illness, and laboratory data, was collected at the time of diagnosis. Information on the number of ventilator-free days (VFDs) and changes in PaO2/FIO2 (ΔP/F) before and 7 days after the time of ALI diagnosis was also collected. The effect of sivelestat on ALI patients was also examined based on whether they had sepsis and whether their initial serum procalcitonin level was ≥0.5 ng/mL. Results There were 70 patients who were treated with sivelestat and 40 control patients. VFDs and ΔP/F were significantly higher in the treated patients than in the control patients. However, there was no significant difference in the patient survival rate between the two groups. Sivelestat was more effective in ALI patients with a PaO2/FIO2 ratio ≥ 140 mmHg or sepsis. Sivelestat significantly prolonged survival and led to higher VFDs and increased ΔP/F in septic patients and patients with initial serum procalcitonin levels ≥ 0.5 ng/mL. Conclusion The results may facilitate a future randomized controlled trial to determine whether sivelestat is beneficial for ALI patients with sepsis.
Monetary Policy Implications of Comovements Among Long-Term Interest Rates

This paper examines the monetary policy implications from the greater integration of major capital markets using long-term interest rates. Proof that globalization has affected the behavior of interest rates and made them more synchronized across countries is provided from the way disturbances in a market transmit to other markets thereby affecting the conduct of monetary policy in all involved parties. The results also confirm greater convergence among countries in the European Union as Germany still retains its hegemonic status. The implications for monetary policy are that countries now will have to deal with more outside shocks and these shocks will be more diverse, intense and persistent. Thus, global monetary policy, at least among the major capital markets, henceforth will have to be played interactively, which may necessitate a greater financial supervision in order to ensure continued world stability and prosperity.
Måleegenskaper ved den norske versjonen av Autism Diagnostic Observation Schedule, Second Edition (ADOS-2)

Description. The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2)(Lord, et al., 2012) was designed to assess and diagnose autism spectrum disorders (ASDs) across developmental levels, language skills, and age The ADOS-2 was developed by Lord et al. and is a revised version of the original ADOS-G (Lord, et al., 2000). The revision includes new and revised algorithms for the modules 1 – 4 and a Toddler Module intended for children between 12 and 30 months of age, who do not consistently use phrase speech (Hus & Lord, 2014). This means that the ADOS-2 can be used with a wide range of individuals; from one-year-olds with no speech to adults. The included severity scales facilitate comparisons across the different modules. The test, which comprises five modules, five Protocol Booklets and a manual, was translated into Norwegian by Synnve Schölberg, Kenneth Larsen and Niels Petter Thorkildsen in 2014. Proper PsykTestBarn 2018, 1:4. doi:10.21337/0059 http://www.psyktestbarn. no/CMS/ptb.nsf/pages/ados-autism-diagnostic-observation-schedule 3 administration of the test requires adequate knowledge of both the test and ASDs; e.g., clinicians who have received special training. Copyright © 2012 Western Psychological Services, Högrefe Psykologiforlaget AB © has the Norwegian translation rights. The administration of the ADOS-2 takes approximately 40 to 60 minutes. The scores are based on all tasks across the test, and the algorithms are closely related to the diagnostic criteria.
Indirect Instantaneous Car-Fuel Consumption Measurements

A method to estimate the instantaneous fuel consumption of a personal car, using speed and height data recorded by a global positioning system receiver and vehicle parameters accessible via national vehicle registers and databases on the world wide web, is proposed. The method is based upon a physical model describing the relationship between the dynamics of the car, engine speed, and energy consumption of the system. An evaluation of the proposed method is done by comparing the estimated instantaneous fuel consumption with that measured by the car's onboard diagnostics data bus. The results of three tests with different cars driven in mixed highway and urban conditions indicate that the instantaneous fuel consumption may be estimated with a root mean square error of ~0.3 [g/s], in terms of a normalized mean square error, that corresponded to slightly <;10%. One application of the proposed method is in the development of smartphone applications that educate drivers to drive more fuel efficiently.
The extreme limit of the generalised Chaplygin gas

Unified Dark Matter models describe Dark Matter and Dark Energy as a single entity which is, in the simplest case, embodied in a perfect barotropic fluid. It is a well-established fact that small adiabatic perturbations of Unified Dark Matter have an evolution characterised by oscillations and decay which provide predictions on the Cosmic Background Radiation anisotropies which are in poor agreement with observation. In this paper we investigate the generalised Chaplygin gas and we find that the Integrated Sachs-Wolfe effect excludes the model for 10−3 < α < 350. We discuss the implications on the background evolution of the Universe if large values of α are considered. In this case, the Universe expansion mimics a matter-dominated phase abruptly followed by a de Sitter one at the transition redshift ztr. Thanks to an analysis of the type Ia supernovae Constitution set we are able to place ztr = 0.22.
Performance of a low cost magnifying device, magnivisualizer, versus colposcope for detection of pre-cancer and cancerous lesions of uterine cervix

Objective To assess the performance of a low cost magnifying device (Magnivisualizer) compared to a standard optical colposcope for detection of precancerous and cancerous lesions of the uterine cervix. Methods A total of 659 consecutive symptomatic women attending a gynecologic outpatient clinic underwent unaided visual inspection followed by cytology, visual inspection of the cervix using 5% acetic acid (VIA), and VIA under magnification (VIAM) with the Magnivisualizer. All women, independently of test results, were referred for colposcopic examination. Colposcopic-directed biopsies were obtained from all positive lesions and compared to positive VIAM cases. Results The detection rate for VIA positive lesions was 12% (134/659), while it was 29% for VIAM positive lesions (191/659). The sensitivities of detection of cervical intraepithelial neoplasia (CIN) 2 and higher lesions were 61.7% for VIA, 88.3% for VIAM, and 86.7% for colposcopy, with a specificity of 58.5% for VIA, 55.8% for VIAM, and 90.4% for colposcopy. The performance of colposcopy and VIAM was moderate (κ, 0.48; 95% confidence interval [CI], 0.41 to 0.54) for detection of CIN 1 and higher lesions and excellent (κ, 0.87; 95% CI, 0.82 to 0.94) for detection of CIN 2 and higher lesions. Conclusion In low resource settings, where colposcopic facilities are not available at the community level, a simple low-cost, handheld Magnivisualizer can be considered a valid option for detection of cervical precancerous and cancerous lesions. However, it cannot replace traditional colposcopy because it has a low specificity that results in many unnecessary biopsies.
Mu-Opioid Stimulation in Rat Prefrontal Cortex Engages Hypothalamic Orexin/Hypocretin-Containing Neurons, and Reveals Dissociable Roles of Nucleus Accumbens and Hypothalamus in Cortically Driven Feeding

Mu-opioid receptor (μOR) stimulation within ventral medial prefrontal cortex (vmPFC) induces feeding and hyperactivity, resulting possibly from recruitment of glutamate signaling in multiple vmPFC projection targets. We tested this hypothesis by analyzing Fos expression in vmPFC terminal fields after intra-vmPFC μOR stimulation, and by examining of the impact of glutamate receptor blockade in two feeding-related targets of vmPFC, the lateral-perifornical hypothalamic area (LH-PeF) and nucleus accumbens shell (Acb shell), upon behavioral effects elicited by intra-vmPFC μOR stimulation in rats. Intra-vmPFC infusion of the μOR agonist, DAMGO, provoked Fos expression in the dorsomedial sector of tuberal hypothalamus (including the perifornical area) and increased the percentage of Fos-expressing hypocretin/orexin-immunoreactive neurons in these zones. NMDA receptor blockade in the LH-PeF nearly eliminated intra-vmPFC DAMGO-induced food intake without altering DAMGO-induced hyperactivity. In contrast, blocking AMPA-type glutamate receptors within the Acb shell (the feeding-relevant subtype in this structure) antagonized intra-vmPFC DAMGO-induced hyperlocomotion but enhanced food intake. Intra-vmPFC DAMGO also elevated the breakpoint for sucrose-reinforced progressive-ratio responding; this effect was significantly enhanced by concomitant AMPA blockade in the Acb shell. Conversely, intra-Acb shell AMPA stimulation reduced breakpoint and increased nonspecific responding on the inactive lever. These data indicate intra-vmPFC μOR signaling jointly modulates appetitive motivation and generalized motoric activation through functionally dissociable vmPFC projection targets. These findings may shed light on the circuitry underlying disorganized appetitive responses in psychopathology; e.g., binge eating and opiate or alcohol abuse, disorders in which μORs and aberrant cortical activation have been implicated.
A 2.5-dB NF 3.1–10.6-GHz CMOS UWB LNA with small group-delay-variation

A 3.1-10.6-GHz ultra-wideband low-noise amplifier (UWB LNA) with excellent phase linearity property (group-delay-variation is only plusmn16.7 ps across the whole band) using standard 0.13 mum CMOS technology is reported. To achieve high and flat gain and small group-delay-variation at the same time, the inductive peaking technique is adopted in the output stage for bandwidth enhancement. The UWB LNA dissipates 10.68 mW power and achieves input return loss (S11) of -17.5 ~ -33.6 dB, output return loss (S22) of -14.4 ~ -16.3 dB, flat forward gain (S21) of 7.92 plusmn 0.23 dB, and reverse isolation (S12) of -25.8 ~ -41.9 dB over the 3.1-10.6 GHz band of interest. State-of-the-art noise figure (NF) of 2.5 dB is achieved at 10.5 GHz. The measured 1-dB compression point (P1dB) and input third-order inter-modulation point (IIP3) were -14 dBm and -4 dBm, respectively, at 6 GHz.
ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains

Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zα domain, which binds specifically to left-handed Z-DNA and Z-RNA. Like all vertebrate proteins in the Zα family, it contains two Zα-like domains and is highly inducible by immunostimulation. Using circular dichroism spectroscopy and electrophoretic mobility shift assays we show that both Zα domains can bind Z-DNA independently and that substrate binding is greatly enhanced when both domains are linked. Full length ZBP1 and a prominent splice variant lacking the first Zα domain (ΔZα) showed strikingly different subcellular localizations. While the full length protein showed a finely punctate cytoplasmatic distribution, ZBP1ΔZα accumulated in large cytoplasmic granules. Mutation of residues important for Z-DNA binding in the first Zα domain resulted in a distribution comparable to that of ZBP1ΔZα. The ZBP1ΔZα granules are distinct from stress granules (SGs) and processing bodies but dynamically interacted with these. Polysome stabilization led to the disassembly of ZBP1ΔZα granules, indicating that mRNA are integral components. Heat shock and arsenite exposure had opposing effects on ZBP1 isoforms: while ZBP1ΔZα granules disassembled, full length ZBP1 accumulated in SGs. Our data link ZBP1 to mRNA sorting and metabolism and indicate distinct roles for ZBP1 isoforms.
ANGGARAN BERBASIS GENDER : ALOKASI ANGGARAN SEKTOR PENDIDIKAN DAN KESEHATAN DI KABUPATEN KENDAL TAHUN 2006-2008

Key words : Policy, Gender Mainstreaming, Gender Budget In this research, the writer will study about how is wisdom of Kendal regency government in Gender Mainstreaming implementation and how far government pay attention gender equality and justice in local budget. In Research method, research type is descriptive analysis with data source from primary and sekunder data. Technique collecting data through Indepth Interview and Documentation Study. Data analysis through reduction data, display data and verification. From this research out put getted that local budget in Kendal regency not yet sensitive gender. This matter because of budget allocation for education and health sector still minimum that is less than 1%. Government commitment in implementation of Gender Mainstreaming through local budget not yet stand-out
The AGB population of NGC 6822: distribution and the C/M ratio from JHK photometry

Context. NGC 6822 is an irregular dwarf galaxy and part of the Local Group. Its close proximity and apparent isolation provide a unique opportunity to study galactic evolution without any obvious strong external influences. Aims. This paper aims to study the spatial distribution of the asymptotic giant branch (AGB) population and metallicity in NGC 6822. Methods. Using deep, high quality JHK photometry, taken with WFCAM on UKIRT, carbon- and oxygen-rich AGB stars have been isolated. The ratio between their number, the C/M ratio, has then been used to derive the [Fe/H] abundance across the galaxy. Results. The tip of the red giant branch is located at K0 = 17.41± 0.11 mag and the colour separation between carbon- and oxygenrich AGB stars is at (J− K)0 = 1.20± 0.03 mag (i.e. (J− K)2MAS S ∼ 1.28 mag). A C/M ratio of 0.62± 0.03 has been derived in the inner 4 kpc of the galaxy, which translates into an iron abundance of [Fe/H] =−1.29± 0.07 dex. Variations of these parameters were investigated as a function of distance from the galaxy centre and azimuthal angle. Conclusions. The AGB population of NGC 6822 has been detected out to a radius of 4 kpc giving a diameter of 56 arcmin. It is metal-poor, but there is no obvious gradient in metallicity with either radial distance from the centre or azimuthal angle. The detected spread in the TRGB magnitude is consistent with that of a galaxy surrounded by a halo of old stars. The C/M ratio has the potential to be a very useful tool for the determination of metallicity in resolved galaxies but a better calibration of the C/M vs. [Fe/H] relation and a better understanding of the sensitivities of the C/M ratio to stellar selection criteria is first required. ⋆⋆
Technology Attentional Models of Multitask Pilot Performance Using Advanced Display

can be found at: Society Human Factors: The Journal of the Human Factors and Ergonomics Additional services and information for http://hfs.sagepub. com/cgi/alerts Email Alerts: http://hfs.sagepub. com/subscriptions Subscriptions: http://www.sagepub. com/journalsReprints.nav Reprints: http://www.sagepub. com/journalsPermissions.nav Permissions: http://hfs.sagepub. com/content/45/3/360.refs.html Citations:
THE AGES OF A-STARS. I. INTERFEROMETRIC OBSERVATIONS AND AGE ESTIMATES FOR STARS IN THE URSA MAJOR MOVING GROUP

We have observed and spatially resolved a set of seven A-type stars in the nearby Ursa Major moving group with the Classic, CLIMB, and PAVO beam combiners on the Center for High Angular Resolution Astronomy Array. At least four of these stars have large rotational velocities ( v sin i ≳ ? > 170 km s − 1 ? > ) and are expected to be oblate. These interferometric measurements, the stars’ observed photometric energy distributions, and v sin i ? > values are used to computationally construct model oblate stars from which stellar properties (inclination, rotational velocity, and the radius and effective temperature as a function of latitude, etc.) are determined. The results are compared with MESA stellar evolution models to determine masses and ages. The value of this new technique is that it enables the estimation of the fundamental properties of rapidly rotating stars without the need to fully image the star. It can thus be applied to stars with sizes comparable to the interferometric resolution limit as opposed to those that are several times larger than the limit. Under the assumption of coevality, the spread in ages can be used as a test of both the prescription presented here and the MESA evolutionary code for rapidly rotating stars. With our validated technique, we combine these age estimates and determine the age of the moving group to be 414 ± 23 Myr, which is consistent with, but much more precise than previous estimates.
Does International Law Matter

"Does international law matter? " That such a skeptical question is posed is troubling. The question of whether international law matters echoes older questions we have debated, but it is also new and has a particularly American flavor. It is American both in the sense that we have very high expectations that international law, like all of law, should matter and in the sense that we are disappointed with it when it does not stop a terrorist or a war. It is troubling in that there are senior officials in this administration who have asserted, and would assert again, that international law does not matter. So I stress at the outset that this question is not merely an audience teaser. It is a serious and deeply troubling question and one posed part icularly for America at this time. I offer a partial reply in five parts.