Miracle-dz/UniFAR-FTUs huggingface dataset:
Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer

Normal homeostasis of adult intestinal epithelium and repair following tissue damage is maintained by a balance of stem and differentiated cells, many of which are still only poorly characterised. Enteroendocrine cells of the gut are a small population of differentiated, secretory cells that are critical for integrating nutrient sensing with metabolic responses, dispersed amongst other epithelial cells. Recent evidence suggests that sub-sets of secretory enteroendocrine cells can act as reserve stem cells. Given the link between cells with stem-like properties and cancer, it is important that we identify factors that might provide a bridge between the two. Here, we identify a sub-set of chromogranin A-positive enteroendocrine cells that are positive for the developmental and cancer-associated transcription factor Brachyury in normal human small intestinal and colonic crypts. Whilst chromogranin A-positive enteroendocrine cells are also Brachyury-positive in colorectal tumours, expression of Brachyury becomes more diffuse in these samples, suggesting a more widespread function in cancer. The finding of the developmental transcription factor Brachyury in normal adult human intestinal crypts may extend the functional complexity of enteroendocrine cells and serves as a platform for assessment of the molecular processes of intestinal homeostasis that underpins our understanding of human health, cancer and aging.
A Review of Current Sociological Research on Teachers’ Emotions: The Way Forward

During the mid-1990s, teachers’ emotions emerged as an area of research in the sociology of teaching because many teachers all over the world were reported to be unhappy, dissatisfied, stressed, frustrated, and even alienated. This implies that teachers’ emotions, especially negative ones, go beyond individual factors and have become a social issue. Therefore, researchers use sociological perspectives and theories to deepen our understanding of the phenomenon. In order to advance the development of this newly-emerged field in sociology, this article reviews the sociological theories commonly applied to study teachers’ emotions: labor process theory, emotional labor theory, and theory of emotional geographies. It is suggested that the theories focus on either structural or agential influences to teachers’ emotions. It may limit their explanation about teachers’ emotions because emotions are constructed and conditioned by teacher agency and socio cultural structure. Thus, this article proposes a sociological framework which considers both structural and agential effects to teachers’ emotions. Moreover, a research agenda is also addressed in this article.
Effects of aerobic exercise training on peripheral brain-derived neurotrophic factor and eotaxin-1 levels in obese young men

[Purpose] The aim of the present study was to investigate the effects of aerobic exercise training on the levels of peripheral brain-derived neurotrophic factor and eotaxin-1 in obese young men. [Subjects and Methods] The subjects included sixteen obese young men with a body mass index greater than 25 kg/m2. They were randomly divided between control and exercise groups (n = 8 in each group). The exercise group performed treadmill exercise for 40 min, 3 times a week for 8 weeks at the intensity of 70% heart rate reserve. Blood collection was performed to examine the levels of serum glucose, plasma malonaldehyde, serum brain-derived neurotrophic factor, and plasma eotaxin-1 before and after the intervention (aerobic exercise training). [Results] Following the intervention, serum BDNF levels were significantly higher, while serum glucose, plasma MDA, and plasma eotaxin-1 levels were significantly lower than those prior to the intervention in the exercise group. [Conclusion] Aerobic exercise training can induce neurogenesis in obese individuals by increasing the levels of brain-derived neurotrophic factor and reducing the levels of eotaxin-1. Alleviation of oxidative stress is possibly responsible for such changes.
Glycemic index: is it a predictor of metabolic and vascular disorders?

Purpose of review The role of glycemic index on metabolic and cardiovascular risk factors received considerable attention in light of the current increase in cardiometabolic disorders. We aimed to deal and identify the recently published prospective epidemiological studies as well as randomized controlled studies investigating the associations of metabolic and cardiovascular risk markers with dietary intake of carbohydrates and with measures of the induced glycemic index. The main prospective studies and meta-analysis grouping the recent prospective and clinical interventions are discussed. Recent findings Recently, during the last few years, evidence exists that high glycemic index/glycemic load diets contribute to risk of type 2 diabetes and cardiovascular disease. Additionally, low glycemic index/glycemic load diets were found to be effective in the treatment of cardiometabolic disorders. Summary The use of the low glycemic index notion in the dietary recommendations for children, adolescents and adults might play a role in the prevention, and or treatment, of metabolic diseases and their cardiovascular complications.
Factors Associated with Dengue Shock Syndrome: A Systematic Review and Meta-Analysis

Background The pathogenesis of dengue shock syndrome (DSS, grade 3 and 4) is not yet completely understood. Several factors are reportedly associated with DSS, a more severe form of dengue infection that reportedly causes 50 times higher mortality compared to that of dengue patients without DSS. However, the results from these reports remain inconclusive. To better understand the epidemiology, clinical manifestation, and pathogenesis of DSS for development of new therapy, we systematically reviewed and performed a meta-analysis of relevant studies that reported factors in both DSS and dengue hemorrhagic fever (DHF, grade 1 and 2) patients. Methods and Findings PubMed, EMBASE, Scopus, Google Scholar, Dengue Bulletin, Cochrane Library, Virtual Health Library, and a manual search of reference lists of articles published before September 2010 were used to retrieve relevant studies. A meta-analysis using fixed- or random-effects models was used to calculate pooled odds ratios (OR) or event rate with corresponding 95% confidence intervals. Assessment of heterogeneity and publication bias, meta-regression analysis, subgroup analysis, sensitivity analysis, and analysis of factor-specific relationships were further performed. There were 198 studies constituting 203 data sets that met our eligibility criteria. Our meta-regression analysis showed a sustained reduction of DSS/dengue hemorrhagic fever (DHF) ratio over a period of 40 years in Southeast Asia, especially in Thailand. The meta-analysis revealed that age, female sex, neurological signs, nausea/vomiting, abdominal pain, gastrointestinal bleeding, hemoconcentration, ascites, pleural effusion, hypoalbuminemia, hypoproteinemia, hepatomegaly, levels of alanine transaminase and aspartate transaminase, thrombocytopenia, prothrombin time, activated partial thromboplastin time, fibrinogen level, primary/secondary infection, and dengue virus serotype-2 were significantly associated with DSS when pooling all original relevant studies. Conclusions The results improve our knowledge of the pathogenesis of DSS by identifying the association between the epidemiology, clinical signs, and biomarkers involved in DSS.
A New Sulfated α-Ionone Glycoside from Sonchus erzincanicus Matthews

Sonchus erzincanicus (Asteraceae) is an endemic species in Turkey, where six Sonchus species grow. In this study, a phytochemical study was performed on the aerial parts of the plant. The study describes the isolation and structure elucidation of five flavonoids and two α-ionone glycosides from S. erzincanicus. The compounds were isolated using several and repeated chromatographic techniques from ethyl acetate and aqueous phases that were partitioned from a methanol extract obtained from the plant. 5,7,3′,4′-Tetrahydroxy-3-methoxyflavone (1) and quercetin 3-O-β-D-glucoside (2) were isolated from the ethyl acetate phase, while corchoionoside C 6’-O-sulfate (3), corchoionoside C (4), luteolin 7-O-glucuronide (5) and luteolin 7-O-β-D-glucoside (6), apigenin 7-O-glucuronide (7) were isolated from the aqueous phase. Corchoionoside C 6’-O-sulfate (3), isolated for the first time from a natural source, was a new compound. The structures of the compounds were elucidated by means of 1H-NMR, 13C-NMR, 2D-NMR (COSY, HMQC, HMBC) and ESI-MS.
How do first-year university students experience inquiry and research, and what are the implications for the practice of inquiry-based learning?

First-year undergraduates on degree programmes in the arts, humanities and social sciences were found by this qualitative study to experience inquiry and research in four distinct ways. Research as ‘gathering information’ and ‘exploring others' ideas’ was associated with learning by engaging independently with a knowledge base. Research as ‘evidencing and developing students' own ideas’ and ‘making discoveries’ was associated with an emergent sense of participation in knowledge-building, understood as the potential to bring something personal or new to an area of study. Students described opportunities to frame their own lines of inquiry, and inquiry experiences with an open-ended, knowledge-building orientation, as especially empowering in their intellectual and personal development. They also highlighted their need for support in carrying out research and inquiry. The authors present a conceptual framework for inquiry-based learning that was developed on the basis of this study, and that has been found useful for pedagogical design and research/evaluation.
Financial inclusion and social financialisation: Britain in a European context

Purpose – The article aims to discuss findings from a knowledge exchange review of financial inclusion in Britain and compare these to key features of financial exclusion evident from European analyses. Design/methodology/approach – This paper is based on an innovative knowledge exchange project. Rapid research reviews analysed evidence on financial exclusion in Britain in relation to access to banking services; to credit; to household insurance; personal savings and assets; money advice provision; and financial capability. The findings from these reviews were discussed by stakeholders representing the private, government, community and civil society sectors in a series of evidence review forums. The results of these discussions were summarised and reconsidered at a national knowledge exchange conference. Throughout the project, stakeholders exchange opinions about the state of financial exclusion knowledge through an online discussion forum. Findings – The research identified agreement among British stak.
A Three-Variable Model Predicts Short Survival in Patients With Newly Diagnosed Metastatic Renal Cell Carcinoma

Background Patients with metastatic renal cell carcinoma (mRCC) have variable survival outcomes. When discussing management approaches and providing information to patients and caregivers, it is important to have realistic perspectives, especially if the expected prognosis is very unfavorable. In the present study, factors predicting this endpoint were analyzed. Methods Data from 60 patients treated in routine clinical practice were evaluated. Unfavorable prognosis was defined as death within approximately 3 months from diagnosis of mRCC (maximum 3.5 months). Baseline factors including laboratory values and management approach were compared between the groups with short and longer survival. Results A total of 48 patients (80%) experienced ≥ 4 months survival (4+MS) and 10 (16.7%) experienced shorter survival (3MS). The others had short follow-up. Adverse prognostic factors that were significantly more frequent in the 3MS group were low hemoglobin, high lactate dehydrogenase and lack of systemic therapy. We used these three items to create a prognostic model: score 0 = no adverse factors, score 1 = one adverse factor, score 2 = two adverse factors, score 3 = three adverse factors. In the score 0 group, one out of 20 patients experienced 3MS (5%). In score 1, two out of 21 patients belonged to the 3MS group (9.5%). For score 2, the corresponding figure was four out of 14 patients (29%). In the score 3 group, three out of three patients experienced 3MS (100%) (P = 0.0001). Conclusions A simple model with three prognostic factors predicted survival of patients with newly diagnosed mRCC. Additional validation in other databases is warranted.
Underlining versus repetitive reading.

Two experiments were performed to determine whether underlining was superior to repetitive reading on a completion test following a delayed review period. In the first study there were four conditions making up a 2X2 analysis of variance. The conditions were underlining vs repetitive reading X 9-minute vs 4l/z -minute review. In the second study there were two conditions, underlining vs repetitive reading. In the first study there was no significant difference for underlining vs repetitive reading, however, the difference between the 9* and 4c]/2 -minute review was significant (p < .05). In the second study there were no significant differences. COLLEGES and other agencies, pressed by re quests for assistance for failing students, find themselves in a position of providing instruc| tion in study skills. Their recommendations re garding effective study generally are based on in tuition rather than empirical demonstration. The search for general strategies of study has, in fact, been uneventful. In comparing repetitive reading with a com bination of reading, underlining, precis writing, and review, Dynes (3) found the combined pack age to be superior. Arnold (1) compared four separate techniques of studying historical prose material. The techniques used were: repetitive reading (no writing) ; underlining and marginal notemaking; outlining; and precis writing. Though underlining and marginal notemaking showed a "tendency toward higher scores/' there were no significant differences on either im mediate or delayed recall tests. In a later study, Stordahl and Christensen (7) studied the effects of four study methods on subject matter relevant to a USAF Extension Institute. The study meth ods were: reading and underlining; reading and outlining; reading and summarizing; and repeti tive reading. A multiple-choice test was admin istered immediately after studying the material and 1 week later. Again no significant differences were found. Noall (4) compared reading to lis tening and listening with note-taking. On im mediate recall, reading was superior to listening with note-taking. On delayed recall, reading was superior to both listening and listening with note taking. A common attribute of these paradigms is the immediate and delayed recall measure. It seems logical to assume, however, that most study meth ods are not tactically employed for use in origi nal learning. One underlines, outlines, or writes a precis in order to facilitate review of the ma terial before testing. It is to this question that we address ourselves. Specifically, are reading and underlining superior to reading when Ss are tested after a delayed review period? If our as sumption that students underline in order to facilitate review is correct, we would predict that performance of Ss who underline would be su perior to that of those who merely read. Further more,, in the case of limited review the advantage of returning to underlined material should be greater with a shorter review period. Conse quently, we would predict review time to inter act with study method.
Optical Slot-Waveguide Based Biochemical Sensors

Slot-waveguides allow light to be guided and strongly confined inside a nanometer-scale region of low refractive index. Thus stronger light-analyte interaction can be obtained as compared to that achievable by a conventional waveguide, in which the propagating beam is confined to the high-refractive-index core of the waveguide. In addition, slot-waveguides can be fabricated by employing CMOS compatible materials and technology, enabling miniaturization, integration with electronic, photonic and fluidic components in a chip, and mass production. These advantages have made the use of slot-waveguides for highly sensitive biochemical optical integrated sensors an emerging field. In this paper, recent achievements in slot-waveguide based biochemical sensing will be reviewed. These include slot-waveguide ring resonator based refractometric label-free biosensors, label-based optical sensing, and nano-opto-mechanical sensors.
Efficiently Learning Metric and Topological Maps with Autonomous Service Robots (Effizientes Lernen metrischer und topologischer Karten mit autonomen Servicerobotern)

Summary Models of the environment are needed for a wide range of robotic applications, from search and rescue to automated vacuum cleaning. Learning maps has therefore been a major research focus in the robotics community over the last decades. In general, one distinguishes between metric and topological maps. Metric maps model the environment based on grids or geometric representations whereas topological maps model the structure of the environment using a graph. The contribution of this paper is an approach that learns a metric as well as a topological map based on laser range data obtained with a mobile robot. Our approach consists of two steps. First, the robot solves the simultaneous localization and mapping problem using an efficient probabilistic filtering technique. In a second step, it acquires semantic information about the environment using machine learning techniques. This semantic information allows the robot to distinguish between different types of places like, e. g. , corridors or rooms. This enables the robot to construct annotated metric as well as topological maps of the environment. All techniques have been implemented and thoroughly tested using real mobile robot in a variety of environments. Zusammenfassung Umgebungsmodelle sind die Grundlage für viele Applikationen innerhalb der mobilen Robotik wie beispielsweise Rettungsaufgaben oder autonomes Staubsaugen. Techniken zum Bauen von Karten mit mobilen Robotern werden daher seit vielen Jahren intensiv untersucht. Meist unterscheidet man hier zwischen metrischen und topologischen Karten. Metrische Modelle verwenden geometrische Darstellungen, wohingegen topologische Karten typischerweise durch Graphen repräsentiert werden. Der Beitrag dieser Arbeit besteht in einem Verfahren zum Erstellen von metrischen wie auch topologischen Karten, basierend auf Daten, die mittels Abstandssensoren aufgenommen wurden. Unser Ansatz basiert auf zwei Schritten. Zuerst wird das so genannte simultane Lokalisierungs- und Kartenbauproblem mit Hilfe wahrscheinlichkeitstheoretischer Filtertechniken gelöst. Im zweiten Schritt schätzt unser Verfahren semantische Informationen über Orte in der Umgebung. Diese Technik erlaubt es einem Roboter beispielsweise zu entscheiden, ob dieser sich gerade in einem Raum, einem Türrahmen oder in einem Korridor befindet. Dadurch kann der Roboter die metrische Karte annotieren und somit die Topologie schätzen. Um Klassifikationsfehler zu minimieren, verwenden wir eine probabilistische Relaxationsmethode. Das hier vorgestellte Verfahren wurde implementiert und mit Hilfe echter mobiler Roboter intensiv getestet und evaluiert.
Tweeting and Treating: How Hospitals Use Twitter to Improve Care

Hospitals that have adopted Twitter primarily use it to share organizational news, provide general health care information, advertise upcoming community events, and foster networking. The purpose of this study was to explore the benefits that Twitter utilization has had in improving quality of care, access to care, patient satisfaction, and community footprint while assessing the barriers to its implementation. The methodology used was a qualitative study with a semistructured interview combined with a literature review, which followed the basic principles of a systematic review. The utilization of Twitter by hospitals suggest that it leads to savings of resources, enhanced employee and patient communication, and expanded patient reach in the community. Savings opportunities are generated by preventing unnecessary office visits, producing billable patient encounters, and eliminating high recruiting costs. Communication is enhanced using Twitter by sharing organizational content, news, and health promotions and can be also a useful tool during crises. The utilization of Twitter in the hospital setting has been more beneficial than detrimental in its ability to generate opportunities for cost savings, recruiting, communication with employees and patients, and community reach.
KOMITMEN KERJA TERHADAP KINERJA PEGAWAI PADA DINAS KOPPERINDAG DAN UMKM KABUPATEN DHARMASRAYA

The purpose of this study was to analyze: 1) the effect of leadership on organizational culture, 2) the effect of leadership on employee commitment, 3) the influence of organizational culture on employee commitment, 4) The effect of leadership on employee performance, 5) The influence of organizational culture on employee performance , 6) Effect of work commitment on employee performance. The population of this study were all employees of the Dinas Kopperindag dan UMKM Kabupaten Dharmasraya totaling 63 people. The sampling method is proportional stratified random sampling. The number of samples is 54 employees. Data analysis techniques to test the hypothesis of the study was the analysis of line with kaedah kaedah test used was the F test and t test. The results of the study found that: 1) Leadership significant positive impact on organizational culture and Dinas Kopperindag dan UMKM Kabupaten Dharmasraya. 2) Leadership significant positive impact on employee commitment Dinas Kopperindag dan UMKM Kabupaten Dharmasraya. 3) Organizational culture have a significant positive impact on employee commitment Dinas Kopperindag dan UMKM Kabupaten Dharmasraya. 4) Leadership significant positive effect on the performance of Dinas Kopperindag dan UMKM Kabupaten Dharmasraya. 5) organizational culture have a significant positive effect on employee performance Dinas Kopperindag dan UMKM Kabupaten Dharmasraya. 6) Commitment work significantly positive effect on employee performance Dinas Kopperindag dan UMKM Kabupaten Dharmasraya. In an effort to improve the performance of employees in the Dinas Kopperindag dan UMKM Kabupaten Dharmasraya need to be improved implementation of leadership functions, improve organizational culture and improving work commitment in carrying out duties