Miracle-dz/UniFAR-FTUs huggingface dataset:
A Thematic Analysis of Perceptions of Adversity, Protective Factors, and Competence among Colombian Immigrant Youth in Canada

A Thematic Analysis of Perceptions of Adversity, Protective Factors, and Competence among Colombian Immigrant Youth in Canada Maria Cabal Garces Advisor: University of Guelph, 2013 Dr. Susan Chuang Using an ecological framework, this study investigated how the resilience-related concepts of competence, adversity, and protective factors were defined by Colombian immigrant youth living in Canada. Ten Colombian immigrant youth, aged 14 to 19 years, were interviewed about their perceptions of ‘doing well’, the main challenges they experienced after arriving in Canada, and the factors that helped them overcome their major challenges. Qualitative thematic analysis was used to analyze the youth’s responses. Youth described how familism played a central role in the perceptions of competence and doing well. It was also found that the main challenges that were reported were general experiences of immigration and the difficulties of adapting into the new cultural environment and not to cultural discrepancies or clashes of values and beliefs. These youth talked about a range of protective factors, which included meaningful relationships (i.e., family, peers, God), individual factors (i.e., coping strategies, change in mindset, personal qualities, previous experiences, setting goals, and language brokering) and environmental factors (i.e., media, school environment, extracurricular activities, and community).
Gait pattern generation and stabilization for humanoid robot based on coupled oscillators

To achieve a balanced walking for a humanoid, it is necessary to estimate the dynamic stability of the system. However, in a small size humanoid with restricted system resource, it is hard to satisfy the performance level desired by dynamics analysis. Therefore, in this paper, we propose the feasible methods to generate gait pattern and stabilize walking based on coupled oscillators which have a clear correlation between oscillator parameters and system dynamics without a real time ZMP calculation. The proposed method was tested on the open humanoid platform DARwIn-OP for the evaluation, and the result showed that a real time gait pattern generation and stabilization were realized.
A Human Anti-M2 Antibody Mediates Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Cytokine Secretion by Resting and Cytokine-Preactivated Natural Killer (NK) Cells

The highly conserved matrix protein 2 (M2) is a good candidate for the development of a broadly protective influenza vaccine that induces long-lasting immunity. In animal models, natural killer (NK) cells have been proposed to play an important role in the protection provided by M2-based vaccines through a mechanism of antibody-dependent cell-mediated cytotoxicity (ADCC). We investigated the ability of the human anti-M2 Ab1-10 monoclonal antibody (mAb) to activate human NK cells. They mediated ADCC against M2-expressing cells in the presence of Ab1-10 mAb. Furthermore, NK cell pro-inflammatory cytokine and chemokine secretion is also enhanced when Ab1-10 mAb is present. We also generated cytokine-preactivated NK cells and showed that they still displayed increased effector functions in the presence of Ab1-10 mAb. Thus, our study has demonstrated that human resting and cytokine-preactivated NK cells may have a very important role in the protection provided by anti-M2 Abs.
Combinatorial expression vector engineering for tuning of recombinant protein production in Escherichia coli

The complex and integrated nature of both genetic and protein level factors influencing recombinant protein production in Escherichia coli makes it difficult to predict the optimal expression strategy for a given protein. Here, two combinatorial library strategies were evaluated for their capability of tuning recombinant protein production in the cytoplasm of E. coli. Large expression vector libraries were constructed through either conservative (ExLib1) or free (ExLib2) randomization of a seven-amino-acid window strategically located between a degenerated start codon and a sequence encoding a fluorescently tagged target protein. Flow cytometric sorting and analyses of libraries, subpopulations or individual clones were followed by SDS-PAGE, western blotting, mass spectrometry and DNA sequencing analyses. For ExLib1, intracellular accumulation of soluble protein was shown to be affected by codon specific effects at some positions of the common N-terminal extension. Interestingly, for ExLib2 where the same sequence window was randomized via seven consecutive NN(G/T) tri-nucleotide repeats, high product levels (up to 24-fold higher than a reference clone) were associated with a preferential appearance of novel SD-like sequences. Possible mechanisms behind the observed effects are discussed.
Population projections for US states under the Shared Socioeconomic Pathways based on global gridded population projections

Population projections across scales are essential for integrated assessment of global environmental changes. Currently, projections at the aggregate national scale, and at the grid-cell scale, are available globally and for many individual countries. However few projections exist at intermediate scales, such as US states, which are important for capturing broad-scale redistribution of population through internal migration. We are currently developing explicit US state-level projections, from which we will create consistent gridded outcomes. Here we present a placeholder set of projections that could be used in analyses while waiting on explicit state projections. These placeholder projections are based on an existing set of global gridded projections, which we aggregate (upscale) to the state level to produce a set of projections numerically consistent at the grid cell, state and national level. We test alternative aggregation methods and geographic resolutions of the gridded population to derive the aggregate state-level projections for all 50 states (and Puerto Rico), for rural and urban areas. Results show that with high resolution gridded population data for the present population, the upscaling outcomes match reasonably well total population at the national and state levels. Comparison of the state-level projections aggregated from the grid cell level to explicit state projections from the US Census Bureau through 2030 show that results are reasonable for many states, but are much less reliable for states experiencing population dynamics differing from national overall patterns. Results therefore also demonstrate the need for a new set of alternative, state-level population projections with consistent gridded outcomes.
Dynamic Spectrum Management With the Competitive Market Model

Ye [¿Competitive Communication Spectrum Economy and Equilibrium,¿ 2008, working paper] and Lin [¿Budget Allocation in a Competitive Communication Spectrum Economy,¿ EURASIP J. Adv. Signal Process. , Article ID: 963717, vol. 2009, p. 12, Sep. 2009] have shown that dynamic spectrum management (DSM) using the market competitive equilibrium (CE), which sets a price for transmission power on each channel, leads to better system performance in terms of the total data transmission rate (by reducing cross talk), than using the Nash equilibrium (NE). But how to achieve such a CE is an open problem. We show that the CE is the solution of a linear complementarity problem (LCP) and can be computed efficiently. We propose a decentralized tatonnement process for adjusting the prices to achieve a CE. We show that under reasonable conditions, any tatonnement process converges to the CE. The conditions are that users of a channel experience the same noise levels and that the crosstalk effects between users are low-rank and weak.
Evaluation of the IMMY ALPHA Histoplasma Antigen Enzyme Immunoassay for Diagnosis of Histoplasmosis Marked by Antigenuria

ABSTRACT The sensitivity of detection of antigenuria in patients positive by the MiraVista Diagnostics Histoplasma enzyme immunoassay (MVD EIA) was 44% with the IMMY ALPHA Histoplasma antigen EIA. The specificity was 84% with the IMMY EIA versus 98% with the MVD EIA. The correlation between assays for positive cases was weak (r2 = 0.430).
Alcohol consumption and all-cause mortality.

BACKGROUND Prospective studies of alcohol and mortality in middle-aged men almost universally find a U-shaped relationship between alcohol consumption and risk of mortality. This review demonstrates the extent to which different studies lead to different risk estimates, analyses the putative influence of abstention as a risk factor and uses available data to produce point and interval estimates of the consumption level apparently associated with minimum risk from two studies in the UK. METHOD Data from a number of studies are analysed by means of logistic-linear modelling, taking account of the possible influence of abstention as a special risk factor. Separate analysis of British data is performed. RESULTS Logistic-linear modelling demonstrates large and highly significant differences between the studies considered in the relationship between alcohol consumption and all-cause mortality. The results support the identification of abstention as a special risk factor for mortality, but do not indicate that this alone explains the apparent U-shaped relationship. Separate analysis of two British studies indicates minimum risk of mortality in this population at a consumption level of about 26 (8.5 g) units of alcohol per week. CONCLUSIONS The analysis supports the view that abstention may be a specific risk factor for all-cause mortality, but is not an adequate explanation of the apparent protective effect of alcohol consumption against all-cause mortality. Future analyses might better be performed on a case-by-case basis, using a change-point model to estimate the parameters of the relationship. The current misinterpretation of the sensible drinking level of 21 units per week for men in the UK as a limit is not justified, and the data suggest that alcohol consumption is a net preventive factor against premature death in this population.
Separate cis-regulatory elements confer expression of phosphoenolpyruvate carboxykinase (GTP) gene in different cell lines.

The gene encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) [PEPCK; GTP:oxaloacetate carboxy-lyase (transphosphorylating), EC 4.1. 1.32], a key enzyme in gluconeogenesis and glyceroneogenesis, is expressed in tissues that arise from different embryonal origins: the gluconeogenic liver arises from endoderm, whereas the gluconeogenic kidney cortex and glyceroneogenic adipose tissue arise from the mesoderm. To identify the cis-regulatory elements conferring the differential gene expression, PEPCK chimeric genes were transfected into two rat hepatoma cell lines (H4IIEC3 and HTC-M1.1) and mouse adipocytes (3T3F442A), which express the endogenous gene, and into myoblasts and preadipocytes, which do not express it. The results demonstrate that 597 base pairs of the 5' flanking region of the PEPCK gene are sufficient to confer cell-specific gene expression in the PEPCK-expressing hepatoma cells and adipocytes. However, different elements within this 597-base-pair region enhance the gene expression in the hepatoma cells (endoderm) and adipocytes (mesoderm). In the hepatocytes, expression is conferred by two elements--one 5' of position -362 and the other 3' of position -98 with respect to the transcription start site. The region in between these two elements (from -362 to -98), which seems to inhibit the gene expression in the hepatocytes, confers enhanced expression in the adipocytes. Moreover, the distal positive regulatory element of the hepatocytes seems to be orientation and PEPCK promoter dependent. In contrast, the positive regulatory element of the adipocytes seems to act as a more typical enhancer. These results suggest that separate cis-regulatory elements confer cell-specific expression of the PEPCK gene.
ACTION OF X-RAYS ON MAMMALIAN CELLS

The effects of x-irradiation have been quantitatively studied on single cells of a human cervical carcinoma (HeLa) under conditions such that 100 per cent of the unirradiated cells reproduce in isolation to form macroscopic colonies. This technique eliminates complexities due to interactions of members of large cell populations. Survival of single cells (defined as the ability to form a macroscopic colony within 15 days) yields a typical 2 hit curve when plotted against x-ray dose. The initial shoulder extends to about 75 r, after which a linear logarithmic survival rate is obtained, in which the dose needed to reduce survivors to 37 per cent is 96 r. This radiation sensitivity is tens to hundreds of times greater than that of any microorganism for which the equivalent function bas been studied. Evidence, though not proof, is presented that the lethal effect is due to a radiation-induced genetic defect which, however, cannot be a simple single gene inactivation. The locus of the action could be chromosomal. Beginning at doses of 100 r, or possibly earlier, growth-delaying effects of radiation are visible. Cells in which the ability to reproduce has been destroyed by doses below 800 r, can still multiply several times. At higher doses even a single cell division is precluded. A large proportion of the cells killed by radiation at any dose gives rise to one or more giant cells. These metabolize actively, grow to huge proportions but never reproduce under the experimental conditions employed. Methods of preparing large populations of giant cells are described. These giants are particularly susceptible to virus action. Some of the irradiated cells disappear from the plate, presumably by disintegration. This action of radiation is by far the least efficient, since even after 10,000 r, 5 to 10 per cent of the original cell inoculum is recoverable as giants.
Detection and Attribution of Changes in Extreme Temperatures at Regional Scale

AbstractThis paper improves an extreme-value-theory-based detection and attribution method and then applies it to four types of extreme temperatures, annual minimum daily minimum (TNn) and maximum (TXn) and annual maximum daily minimum (TNx) and maximum (TXx), using the HadEX2 observation and the CMIP5 multimodel simulation datasets of the period 1951–2010 at 17 subcontinent regions. The methodology is an analog of the fingerprinting method adapted to extremes using the generalized extreme value (GEV) distribution. The signals are estimated as the time-dependent location parameters of GEV distributions fitted to extremes simulated by multimodel ensembles under anthropogenic (ANT), natural (NAT), or combined anthropogenic and natural (ALL) external forcings. The observed extremes are modeled by GEV distributions whose location parameters incorporate the signals as covariates. A coordinate descent algorithm improves both computational efficiency and accuracy in comparison to the existing method, facilitatin.
Observation of high-frequency sound propagation in shallow water with bubbles due to storm and surf

An experiment was performed off the shore of Panama City, FL, to measure the spatial and temporal coherence of high-frequency signals that were transmitted between fixed towers. Transmission was along paths at mid depths in about 10 m of water. During the time of the experiment, there were two stormy days with breaking waves and nearby high surf. It was observed that pulse-to-pulse variations (over seconds) in travel times, over a range of frequencies, increased dramatically from those observed on quiet days. Average travel times also increased by about 3%. Dispersion was also observed. The distance between the source and the receiver towers was approximately 60 m. By assuming that bubbles were either generated by breaking waves and advected down ward and/or generated by surf and advected outward, these results are explained. Estimates of the average bubble density and bubble-density variations are made.
THE EMERGENT 1.1–1.7 μm SPECTRUM OF THE EXOPLANET COROT-2B AS MEASURED USING THE HUBBLE SPACE TELESCOPE

We have used Hubble/WFC3 and the G141 grism to measure the secondary eclipse of the transiting, very hot Jupiter CoRoT-2b in the 1.1–1.7 μm spectral region. We find an eclipse depth averaged over this band equal to parts per million, equivalent to a blackbody temperature of 1788 ± 18 K. We study and characterize several WFC3 instrumental effects, especially the “hook” phenomenon described by Deming et al. We use data from several transiting exoplanet systems to find a quantitative relation between the amplitude of the hook and the exposure level of a given pixel. Although the uncertainties in this relation are too large to allow us to develop an empirical correction for our data, our study provides a useful guide for optimizing exposure levels in future WFC3 observations. We derive the planet's spectrum using a differential method. The planet-to-star contrast increases to longer wavelength within the WFC3 bandpass, but without water absorption or emission to a 3σ limit of 85 ppm. The slope of the WFC3 spectrum is significantly less than the slope of the best-fit blackbody. We compare all existing eclipse data for this planet to a blackbody spectrum, and to spectra from both solar abundance and carbon-rich (C/O = 1) models. A blackbody spectrum is an acceptable fit to the full data set. Extra continuous opacity due to clouds or haze, and flattened temperature profiles, are strong candidates to produce quasi-blackbody spectra, and to account for the amplitude of the optical eclipses. Our results show ambiguous evidence for a temperature inversion in this planet.
Who would benefit from memory training? A pilot study examining the ceiling effect of concurrent cognitive stimulation

Diverse effects of memory training were observed in the literature. One possible factor is the amount of concurrent cognitive training received during the training program. In this pilot study, we recruited 24 elderly adults with or without concurrent cognitive stimulations to attend a memory-training program. Findings suggested that elderly people without concurrent cognitive stimulation could benefit from a memory-training program in the form of improved initiation and memory functioning. Self-rated quality of life measure also showed improvements alongside the cognitive benefits. Elderly people with regular concurrent cognitive stimulation, on the other hand, seemed to plateau in their level of performance and did not show any significant change. Our preliminary findings suggested nonlinear concurrent cognitive stimulation in the elderly.
Determining Semantic Textual Similarity using Natural Deduction Proofs

Determining semantic textual similarity is a core research subject in natural language processing. Since vector-based models for sentence representation often use shallow information, capturing accurate semantics is difficult. By contrast, logical semantic representations capture deeper levels of sentence semantics, but their symbolic nature does not offer graded notions of textual similarity. We propose a method for determining semantic textual similarity by combining shallow features with features extracted from natural deduction proofs of bidirectional entailment relations between sentence pairs. For the natural deduction proofs, we use ccg2lambda, a higher-order automatic inference system, which converts Combinatory Categorial Grammar (CCG) derivation trees into semantic representations and conducts natural deduction proofs. Experiments show that our system was able to outperform other logic-based systems and that features derived from the proofs are effective for learning textual similarity.
A High-Efficiency Dimmable LED Driver for Low-Power Lighting Applications

This paper presents a dimmable light-emitting diode (LED) driver with adaptive feedback control for low-power lighting applications. An improved pulsewidth modulation dimming technique is studied for regulating the LED current and brightness. Under universal input voltage operation, high efficiency and high power factor can be achieved by a coupled inductor single-ended primary inductance converter power factor correction (PFC) converter with a simple commercial transition-mode PFC controller. The operation principles and design considerations of the studied LED driver are analyzed and discussed. A laboratory prototype is also designed and tested to verify the feasibility.
The effect of phenylephrine on the onset time of rocuronium

Background Several studies have demonstrated that ephedrine shortens the onset time of muscle relaxants, and it does so probably by increasing the cardiac output. However, elevation of the systemic blood pressure through α adrenergic stimulation via ephedrine may affect the onset of muscle relaxants during the induction of anesthesia. We investigated the effect of phenylephrine, which is a selective α-1 agonist, on the onset time of rocuronium and the intubating conditions in adults after the administration of propofol. Methods Sixty-four patients were randomly assigned to two groups. Phenylephrine (0.9 µg/kg) (P group) or the same volume of saline (S group) was injected before rocuronium (0.6 mg/kg) administration. Anesthesia was induced with fentanyl 2 µg/kg and propofol 2 mg/kg. The onset time was defined as the time from the end of rocuronium injection to the time when a single twitch height gets to 0% or the minimum level. A well-trained anesthesiologist who was 'blinded' to the treatment groups evaluated the intubating conditions. The mean arterial pressure and heart rate were recorded before induction, before intubation, immediately after intubation and 1 minute and 2 minutes after intubation. Results The onset time was 84 ± 18 sec in the P-group and 72 ± 14 sec in the S-group. There was no difference of the intubating conditions, the mean arterial pressure and the heart rate between the two groups. Conclusions A small dose of phenylephrine, which has a limited effect on blood pressure, delayed the onset time of rocuronium after the administration of propofol, and the vasoconstriction effect of phenylephrine may affect the prolongation of the rocuronium onset time at the induction of anesthesia with using propofol.
Coalitions in Cooperative Wireless Networks

Cooperation between rational users in wireless networks is studied using coalitional game theory. Using the rate achieved by a user as its utility, it is shown that the stable coalition structure, i.e., set of coalitions from which users have no incentives to defect, depends on the manner in which the rate gains are apportioned among the cooperating users. Specifically, the stability of the grand coalition (GC), i.e., the coalition of all users, is studied. Transmitter and receiver cooperation in an interference channel (IC) are studied as illustrative cooperative models to determine the stable coalitions for both flexible (transferable) and fixed (non-transferable) apportioning schemes. It is shown that the stable sum-rate optimal coalition when only receivers cooperate by jointly decoding (transferable) is the GC. The stability of the GC depends on the detector when receivers cooperate using linear multiuser detectors (non-transferable). Transmitter cooperation is studied assuming that all receivers cooperate perfectly and that users outside a coalition act as jammers. The stability of the GC is studied for both the case of perfectly cooperating transmitters (transferrable) and under a partial decode-and-forward strategy (non-transferable). In both cases, the stability is shown to depend on the channel gains and the transmitter jamming strengths.