Miracle-dz/UniFAR-FTUs huggingface dataset:
Cross-cultural generalizability of the Spiritual Transcendence Scale to the Philippines: Spirituality as a human universal

The Spiritual Transcendence Scale (STS) has been developed to operationalize spirituality as an intrinsic source of motivation that impels individuals to create a broad sense of personal meaning for their lives. Spiritual Transcendence is nondenominational in nature and hypothesized to underlie the development of religious sentiments. To further support the universal nature of Spiritual Transcendence, the STS was translated into a native Filipino language, Tagalog. Using two different, varied samples of Filipino adults (N = 654 and 248, respectively), this study demonstrated that scores on the translated version evidenced acceptable levels of internal consistency, structural validity, and incremental validity over personality in predicting a wide range of psychosocial outcomes, like well-being and interpersonal style. Further analyses also indicated that the Tagalog version of the STS produced comparable means and standard deviations to its English counterpart. The data provided support for the hypothesis that spirituality is a robust, universal human quality because two languages that are etymologically distinct both include terms that describe transcendent experiences. The STS appears to be an empirically robust measure of these qualities that can be useful for researchers interested in establishing cross-cultural linkages in spiritual motivation.
Digital lectures for learning gross anatomy: a study of their efficacy

Purpose The current study investigates the level of students’ learning and attitudes towards the teaching and learning process when using digital lectures to teach gross anatomy to year 1 medical students. Methods The study sampled year 1 medical students of cohorts 2013 and 2014. The year 1 medical students in 2013 were taught gross anatomy of the heart by didactic classroom lectures while those in 2014 were taught with digital lectures using the same content. A review session was conducted for the 2014 cohort. A 19-item survey was distributed amongst students to investigate their attitudes and feedback. The data were analysed using SPSS software. Results The 2014 cohort had a mean score of 47.65 for short essay questions and 51.19 for multiple choice questions, while the 2013 cohort scored an average of 36.80 for short essay questions and 49.22 for multiple choice questions. The difference in scores for each type of question was found to be significant. Using a 5-point Likert scale, students gave an average of 4.11 when asked if they liked the teaching and learning process and would like it to be applied further. Conclusion The results of the study provide strong evidence that the digital teaching and learning process was well received by students and could also lead to improved performance. Digital lectures can provide a satisfactory substitute for classroom lectures to teach gross anatomy, thus providing flexibility in learning and efficient learning, whilst also freeing lecture slots to promote mastery learning.
Saturated-State Turbulence and Structure from Thermal and Magnetorotational Instability in the ISM: Three-dimensional Numerical Simulations

This paper reports on three-dimensional numerical simulations of dynamics and thermodynamics in the diffuse interstellar medium (ISM). Our models are local, account for sheared galactic rotation, magnetic fields, and realistic cooling, and resolve scales ≈1-200 pc. This combination permits the study of quasi-steady state turbulence in a cloudy medium representing the warm/cold atomic ISM. Turbulence is driven by the magnetorotational instability (MRI); our models are the first to study the saturated state of MRI under strongly inhomogeneous conditions, with cloud/intercloud density and temperature contrasts of ~100. For volume-averaged densities = 0.25-4 cm-3, the mean saturated-state velocity dispersion ranges from 8 to 1 km s-1, with a scaling δv ∝ -0.77. The MRI is therefore likely quite important in driving turbulence in low-density regions of the ISM, both away from the midplane in the inner Galaxy (as observed at high latitudes) and throughout the far outer Galaxy (where the mean density drops and the disk flares). The MRI may even be key to suppressing star formation at large radii in spiral galaxies, where the pressure can be high enough that without MRI-driven turbulence, a gravitationally unstable cold layer would form. As expected, we find that turbulence affects the thermal structure of the ISM. In all our simulations, the fraction of thermally unstable gas increases as the MRI develops and in the saturated state is largest in high-δv models. The mass fractions of warm stable and unstable gas are typically comparable, in agreement with observations. While inclusion of resistive dissipation of magnetic fields could enhance the amount of thermally unstable gas compared to current models, our present results indicate that even high levels of turbulence cannot wipe out the signature of thermal instability and that a shift to a "phase continuum" description is probably unwarranted. Instead, we find that temperature and density PDFs are broadened (and include extreme departures from equilibrium), but retain the bimodal character of the classical two-phase description. Our presentation also includes results on the distribution of clump masses (the mass spectrum peaks at ~100 M☉), comparisons of saturated-state MRI scalings with single-phase simulation results (we find that ⟨B2⟩ is independent of ), and examples of synthetic H I line profile maps (showing that physical clumps are not easily distinguished in velocity components and vice versa).
Consensual qualitative research: a practical resource for investigating social science phenomena

American Psychological Association, United States, 2011. Hardback. Book Condition: New. 259 x 183 mm. Language: English . Brand New Book. This lively and practical text presents a fresh and comprehensive approach to conducting consensual qualitative research (CQR). CQR is an inductive method that is characterized by open-ended interview questions, small samples, a reliance on words over numbers, the importance of context, an integration of multiple viewpoints, and consensus of the research team. It is especially well-suited to research that requires rich descriptions of inner experiences, attitudes, and convictions. Written to help researchers navigate their way through qualitative techniques and methodology, leading expert Clara E. Hill and her associates provide readers with step-by-step practical guidance during each stage of the research process. Readers learn about adaptive ways of designing studies; collecting, coding, and analyzing data; and reporting findings. Key aspects of the researcher s craft are addressed, such as establishing the research team, recruiting and interviewing participants, adhering to ethical standards, raising cultural awareness, auditing within case analyses and cross analyses, and writing up the study. Intended as a user-friendly manual for graduate-level research courses and beyond, the text will be a valuable resource for both budding and experienced qualitative researchers.
Chromosomal Instability, DNA Index, Dysplasia, and Subsite in Oral Premalignancy as Intermediate Endpoints of Risk of Cancer

Background: Chromosomal instability and aneuploidy may represent biomarkers of oral exposure to damaging agents and early signs of clinical disease according to the theory of “oral field cancerization. ” Methods: The hypothesis was tested that the DNA index (DI) values, obtained by high-resolution DNA flow cytometry (DNA-FCM), may potentially contribute to oral cancer risk prediction. For this purpose, the DI of oral fields of normal-appearing mucosa and oral potentially malignant disorders (OPMDs) in 165 consecutive patients was tested for association with dysplasia and/or the oral subsites of tongue and floor of the mouth taken as high-risk intermediate endpoints surrogate of cancer clinical endpoints. The association was evaluated by logistic regression using patient gender, age, tobacco, cigarette smoking habit, and alcohol abuse as confounding variables. Results: Different DI models provided evidence of statistical significant associations. Subdividing the DI values in diploid, near-diploid aneuploid, and high or multiple aneuploid from both OPMDs and oral normal-appearing mucosa, ORs, respectively, of 1, 4.3 (P = 0.001), and 18.4 (P < 0.0005) were obtained. Conclusion: Routine DI analysis by high-resolution DNA-FCM seems potentially useful to complement dysplasia and subsite analysis for assessment of oral cancer risk prediction and for a better management of the patients with OPMDs. Work is in progress to validate the present findings in a prospective study with clinical endpoints. Impact: Identifying DNA abnormalities in oral premalignancy may lead to biomarkers of oral exposure and cancer risk and potentially to more effective prevention measures. Cancer Epidemiol Biomarkers Prev; 22(6); 1133–41. ©2013 AACR.
Input-agreement: a new mechanism for collecting data using human computation games

Since its introduction at CHI 2004, the ESP Game has inspired many similar games that share the goal of gathering data from players. This paper introduces a new mechanism for collecting labeled data using "games with a purpose. " In this mechanism, players are provided with either the same or a different object, and asked to describe that object to each other. Based on each other's descriptions, players must decide whether they have the same object or not. We explain why this new mechanism is superior for input data with certain characteristics, introduce an enjoyable new game called "TagATune" that collects tags for music clips via this mechanism, and present findings on the data that is collected by this game.
A Reply to Reynolds's Critique of Learning Style

In 1997 Reynolds presented a critique of learning styles in which he lamented the readiness of practitioners to embrace instruments such as the Learning Styles Questionnaire and argued for learning styles and other forms of labelling to be discontinued. It is the contention of this reply that Reynolds may have conflated the concepts of learning styles, learning strategies and cognitive style. While learning style may be a term rendered somewhat meaningless and potentially redundant by over-usage and a weak theoretical base, the notions of cognitive style (for which there is growing empirical and physiological evidence) and learning strategy are valid concepts which managerial learning should incorporate into its pedagogy.
Language in post-colonial Hong Kong : the roles of English and Chinese in the public and private sectors

This article reports the findings of an investigation into the roles of English and Chinese in the workplace in post-1997 Hong Kong. The findings are derived from a questionnaire survey of 1 475 professionals, focus-group interviews and case studies. The study found that English continues to function as the unmarked language of internal and external written communication in both the public and private sectors. Chinese professionals who work for foreign-owned organisations in Hong Kong apparently make greater use of English in written communication than their counterparts in Hong Kong-owned companies, while professionals who work for large Hong Kong concerns read or write in English slightly more than those who work for small local companies. Cantonese is the unmarked language of intra-ethnic spoken communication, particularly in informal situations, while English is generally restricted to situations where expatriates are present.
The effect of pomegranate mouthrinse on Streptococcus mutans count and salivary pH: An in vivo study

Herbal mouthwashes have been considered to be a more advantageous option to their chemical counterparts, for a long-time. The use of pomegranate fruit dates from ancient times and reports of its therapeutic abilities have echoed throughout the ages. To evaluate the effect on the salivary pH and the Streptococcus mutans count in healthy subjects before and after pomegranate mouthrinse. Fifty healthy patients were randomly divided into two groups of 25 subjects each. Group A was treated with 0.2% chlorhexidine mouthrinse; while Group B was treated with pomegranate peel extract (PPE) mouthrinse and the saliva samples were collected at three different intervals: Prerinse, after 10 min, and 60 min. The salivary pH was measured using a digital pH meter and the S. mutans count was determined by the commercial system Dentocult SM. The statistical analyses used in this study are Mann–Whitney U-test and t-test. PPE mouthrinse had an inhibitory effect on S. mutans count in adults. There was also an increase in the salivary pH after 10 min of the mouthrinse. PPE mouthrinse may be considered as a potential anticariogenic mouthrinse.
NEW STRIDES IN SCHIZOPHRENIA RESEARCH

The observation that schizophrenic patients in developing countries tend to remit earlier, have longer periods of symptom remission and less disability (Leff et al, 1992) has been hailed as one of the most important findings in schizophrenia research in the last two decades. The participation of the Agra Center in the International Pilot Study of Schizophrenia which led to the above observation, has been a milestone in psychiatric research in India. This and other projects such as "Determinants of the Outcome of Severe Mental Disorder" and the ICMR study on "Factors affecting Course and Outcome of Schizophrenia" have given a tremendous boost to schizophrenia research in this country. This interest in unravelling the mystery of schizophrenia has been maintained by many research groups and individual investigators in different parts of the country. This issue of the journal has made an attempt to focus attention on some of the different aspects of schizophrenia research carried out by a few of these researchers.
High expression of CD34-positive sinusoidal endothelial cells is a risk factor for hepatocellular carcinoma in patients with HCV-associated chronic liver diseases.

CD34 has been widely used for the assessment of sinusoid-like neoangiogenesis in hepatocellular carcinoma (HCC). Recently, it was demonstrated that CD34-positive cells isolated from human peripheral blood differentiate into endothelial cells and contribute to neoangiogenesis in adults. We investigated the localization and the substantial role of CD34-positive endothelial cells in the liver with hepatitis C virus (HCV)--associated chronic liver diseases. Liver tissue sections obtained by biopsy from 56 patients with HCV-associated chronic liver diseases by were examined immunohistochemically using anti-CD34, anti-von Willebrand factor (vWF), and anti-vascular endothelial growth factor (VEGF) antibodies. CD34 was stained in the sinusoid, showing dotty, linear, semicircular, or circular patterns. However, sinusoidal expression of vWF was not substantially identified in the same specimens, indicating the existence of sinusoidal CD34-positive but vWF-negative endothelial cells. We classified these cells as CD34 LI and found that CD34 LI was correlated with the expression of VEGF. Among 34 patients with advanced-stage disease, the cumulative incidence of HCC was significantly higher in patients with CD34 LI >or= 12 (n = 16) than in those with CD34 LI < 12 (n = 18; P = .009). Moreover, among several clinicopathologic risk factors, CD34 LI could be recognized as an independently significant factor for development of HCC (relative risk, 7.36; P = .019). We conclude that CD34-positive endothelial cells are regulated by several factors, such as VEGF, and might play a substantial role in hepatocarcinogenesis. Furthermore, high expression of CD34-positive sinusoidal endothelial cells is a risk factor for HCC in patients with HCV-associated chronic liver diseases.
Convergent regulation of the lysosomal two‐pore channel‐2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases

Lysosomal Ca2+ homeostasis is implicated in disease and controls many lysosomal functions. A key in understanding lysosomal Ca2+ signaling was the discovery of the two‐pore channels (TPCs) and their potential activation by NAADP. Recent work concluded that the TPCs function as a PI(3,5)P2 activated channels regulated by mTORC1, but not by NAADP. Here, we identified Mg2+ and the MAPKs, JNK and P38 as novel regulators of TPC2. Cytoplasmic Mg2+ specifically inhibited TPC2 outward current, whereas lysosomal Mg2+ partially inhibited both outward and inward currents in a lysosomal lumen pH‐dependent manner. Under controlled Mg2+, TPC2 is readily activated by NAADP with channel properties identical to those in response to PI(3,5)P2. Moreover, TPC2 is robustly regulated by P38 and JNK. Notably, NAADP‐mediated Ca2+ release in intact cells is regulated by Mg2+, PI(3,5)P2, and P38/JNK kinases, thus paralleling regulation of TPC2 currents. Our data affirm a key role for TPC2 in NAADP‐mediated Ca2+ signaling and link this pathway to Mg2+ homeostasis and MAP kinases, pointing to roles for lysosomal Ca2+ in cell growth, inflammation and cancer.
Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl

TMEM88, a newly discovered protein localized on the cell membrane, inhibits canonical Wnt signaling. Immunohistochemic alanalysis of 139 breast cancers pecimens(64 triple-negative cancers and 75 non-triple-negative cancers) indicated that TMEM88 is expressed at significantly higher levels in breast cancer tissues (71.22%, 99/139) than in normal breast tissues (11.4%, 4/35; p < 0.001). The cytosolic and nuclear expression rates of TMEM88 were 57.81% and 9.37% in triple-negative and 52% and 33.33% (p = 0.5 and p = 0.001) in the non-triple-negative breast cancer tissues, respectively. Western blot analyses indicated that TMEM88 promoted Snail expression and inhibited Zo-1 and Occludin expression by interacting with dishevelled (Dvl) proteins, thereby stimulating invasion and metastasis in breast cancer. While cytosolic TMEM88 did not affect canonical Wnt signaling, cytosolic localization of this protein was positively correlated with both advanced TNM stage (p = 0.038 and p < 0.001) and lymph node metastasis (p = 0.01 and p = 0.002) in all and triple-negative specimens, respectively, and stimulated cell invasion by interacting with Dvls. Meanwhile, nuclear localization of TMEM88 was negatively correlated with lymph node metastasis (p = 0.046). Lastly, the increased prevalence of TMEM88 nuclear localization observed in non-triple-negative, compared to triple-negative tissues, suggests that the biological roles of TMEM88 differ depending on the subcellular localization.
The emergence of systematicity in the English pronunciations of two cantonese-speaking adults in Hong Kong

This paper describes and analyses the phenomenon of consonant cluster simplification in the English of two native Cantonesespeakers in Hong Kong. We show that this process is systematic in that it targets the alveolar plosives and removes them when theyare members of a coda consonant cluster in spite of the fact that the details of the simplification may vary from subject to subject.We compare this process to a seemingly similar cluster simplification in native varieties of English and show that they differ in twokey respects. Our study provides evidence of a systematic morphophonemic alternation in the English of L1 Cantonese speakers,confirming the observation in a number of sociolinguistic studies that this process is a linguistic feature of the English of L1Cantonese speakers.
Oral contraceptive use and female genital arousal: Methodological considerations

This study explored effects of oral contraceptive pill (OCP) use on physiological sexual arousal as measured by a vaginal photoplethysmograph. Sixteen women aged 18–29 viewed audiovisual neutral and erotic stimuli before and an average of 6 weeks following the onset of OCP use. Although subjective measures of sexual arousal, including perceptions of genital arousal, significantly increased in response to erotic stimuli both before and after OCP onset, physiological sexual arousal only increased before OCP use. A comparison of individual responses before and after OCP onset reveals a much higher degree of intrasubject variability after OCP onset. We discuss these findings as they relate to OCP use as a confounding methodological variable to consider in future investigations employing vaginal photoplethysmography.
Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?

Despite significant advances in current understanding of mechanisms of pathogenesis in Alzheimer’s disease (AD), attempts at drug development based on those discoveries have failed to translate into effective, disease-modifying therapies. AD is a complex and multifactorial disease comprising a range of aberrant cellular/molecular processes taking part in different cell types and brain regions. As a consequence, therapeutics for AD should be able to block or compensate multiple abnormal pathological events. Here, we examine recent evidence that inhibition of protein tyrosine phosphatase 1B (PTP1B) may represent a promising strategy to combat a variety of AD-related detrimental processes. Besides its well described role as a negative regulator of insulin and leptin signaling, PTB1B recently emerged as a modulator of various other processes in the central nervous system (CNS) that are also implicated in AD. These include signaling pathways germane to learning and memory, regulation of synapse dynamics, endoplasmic reticulum (ER) stress and microglia-mediated neuroinflammation. We propose that PTP1B inhibition may represent an attractive and yet unexplored therapeutic approach to correct aberrant signaling pathways linked to AD.
Evidence for the Existence of an Additional Class of Neuropeptide Y Receptor Sites in Rat Brain

Five distinct neuropeptide Y (NPY) receptors have been cloned thus far. Selective agonists and antagonists have recently been developed allowing for detailed functional studies as to the pathophysiological role of a given subtype as well as receptor binding characteristics and distribution. To precisely investigate the discrete localization and ligand selectivity profile of Y4 and Y5 receptors, a series of selective molecules were used as radioligands and competitors in rat brain tissues. Binding data revealed that Y4 and Y5 receptor-related agonists and antagonists competed with high affinity for specific 125I-[Leu31,Pro34]human peptide YY (hPYY) binding in the presence of BIBO3304 [(R)-N-[[4-(aminocarbonylaminomethyl)-phenyl]-methyl]-N2-(diphenylacetyl)-argininamide trifluoroacetate] to mask Y1 sites as well as specific 125I-labeled human pancreatic polypeptide (hPP) binding. Competition binding profiles were best fitted to a two-site model for both radioligands, suggesting the likely recognition of the Y4 and Y5 subtypes. We were surprised to find that the visualization of these specific binding sites by receptor autoradiography clearly revealed the distinct distribution of specific 125I-[Leu31,Pro34]hPYY (in presence of Y1 and Y5 blockers) and 125I-hPP (in presence of Y5 blocker) binding sites. Moreover, significant amounts of specific 125I-hPP binding were observed in the medial preoptic area, paraventricular nucleus of the hypothalamus, interpeduncular nucleus, and various brainstem nuclei, even after masking Y4 and Y5 receptors. Similar results were obtained using 125I-hPYY(3-36) in presence of Y2 and Y5 blockers. These results suggest the possible existence of at least one additional subtype of NPY receptor sites in the rat brain, with enrichment seen in midbrain and brainstem areas involved in the regulation of food intake and cardiorespiratory parameters.