Miracle-dz/UniFAR-FTUs huggingface dataset:
Dark Energy: The Shadowy Reflection of Dark Matter?

In this article, we review a series of recent theoretical results regarding a conventional approach to the dark energy (DE) concept. This approach is distinguished among others for its simplicity and its physical relevance. By compromising General Relativity (GR) and Thermodynamics at cosmological scale, we end up with a model without DE. Instead, the Universe we are proposing is filled with a perfect fluid of self-interacting dark matter (DM), the volume elements of which perform hydrodynamic flows. To the best of our knowledge, it is the first time in a cosmological framework that the energy of the cosmic fluid internal motions is also taken into account as a source of the universal gravitational field. As we demonstrate, this form of energy may compensate for the DE needed to compromise spatial flatness, while, depending on the particular type of thermodynamic processes occurring in the interior of the DM fluid (isothermal or polytropic), the Universe depicts itself as either decelerating or accelerating (respectively). In both cases, there is no disagreement between observations and the theoretical prediction of the distant supernovae (SNe) Type Ia distribution. In fact, the cosmological model with matter content in the form of a thermodynamically-involved DM fluid not only interprets the observational data associated with the recent history of Universe expansion, but also confronts successfully with every major cosmological issue (such as the age and the coincidence problems). In this way, depending on the type of thermodynamic processes in it, such a model may serve either for a conventional DE cosmology or for a viable alternative one.
A Research on Functional Status, Environmental Conditions, and Risk of Falls in Dementia

This study aimed to determine the effects of disability, physical activity, and functional status as well as environmental conditions on the risk of falls among the elderly with dementia after adjusting for sociodemographic factors. Data were derived from a group including 1210 Malaysian elderly who were demented and noninstitutionalized. The study was a national cross-sectional survey that was entitled “Determinants of Health Status among Older Malaysians. ” Approximately 17% of subjects experienced falls. The results showed that ethnic non-Malay (OR = 1.73) and functional decline (OR = 1.67) significantly increased the risk of falls in samples (P < 0.05). The findings indicated that increased environmental quality (OR = 0.64) significantly decreased the risk of falls (P < 0.05). Disability, age, marital status, educational level, sex differences, and physical activity were found irrelevant to the likelihood of falls in subjects (P > 0.05). It was concluded that functional decline and ethnic non-Malay increased the risk of falls but the increased environmental quality reduced falls.
Value of infliximab (Remicade®) in patients with low-risk myelodysplastic syndrome: final results of a randomized phase II trial (EORTC trial 06023) of the EORTC Leukemia Group

Tumor-necrosis factor alpha activity has been correlated to ineffective erythropoiesis in lower risk myelodysplastic syndromes. Infliximab (Remicade®) is an anti-tumor necrosis factor alpha chimeric antibody that is used in the treatment of patients with rheumatoid arthritis or Crohn’s disease. Forty-six patients with myelodysplastic syndromes and a relatively low risk of developing acute leukemia were included in a randomized phase II study assessing the therapeutic activity of two dosages of infliximab administration (3 mg/kg vs. 5 mg/kg). The primary end point was the response rate. Responses were observed in 3 of 22 patients (13.1%) randomized to the 3 mg/kg arm, versus 0 of 21 patients randomized in the 5 mg/kg arm. According to the statistical design of the current study, neither of the two infliximab dose schedules tested showed sufficient activity as a single agent in this cohort of unselected patients with early myelodysplastic syndrome.
Large-Scale, High-Resolution Data Acquisition System for Extracellular Recording of Electrophysiological Activity

A platform for high spatial and temporal resolution electrophysiological recordings of in vitro electrogenic cell cultures handling 4096 electrodes at a full frame rate of 8 kHz is presented and validated by means of cardiomyocyte cultures. Based on an active pixel sensor device implementing an array of metallic electrodes, the system provides acquisitions at spatial resolutions of 42 mum on an active area of 2.67 mm times 2.67 mm, and in the zooming mode, temporal resolutions down to 8 mus on 64 randomly selected electrodes. The low-noise performances of the integrated amplifier (11 muVrms) combined with a hardware implementation inspired by image/video processing concepts enable high-resolution acquisitions with real-time preprocessing capabilities adapted to the handling of the large amount of acquired data.
Echinococcus P29 Antigen: Molecular Characterization and Implication on Post-Surgery Follow-Up of CE Patients Infected with Different Species of the Echinococcus granulosus Complex

The protein P29 is a potential serological marker for post-treatment monitoring of cystic echinococcosis (CE) especially in young patients. We now have demonstrated that P29 is encoded in the Echinococcus genus by a single gene consisting of 7 exons spanning 1.2 kb of DNA. Variability of the p29 gene at inter- and intra-species level was assessed with 50 cDNA and 280 genomic DNA clones isolated from different E. granulosus s.l. isolates (E. granulosus sensu stricto (G1), E. equinus (G4), E. ortleppi (G5), E. canadensis (G6), E. canadensis (G7) and E. canadensis (G10)) as well as four E. multilocularis isolates. Scarce interspecies polymorphism at the p29 locus was observed and affected predominantly E. granulosus s.s. (G1), where we identified two alleles (A1 and A2) coding for identical P29 proteins and yielding in three genotypes (A1/A1, A2/A2 and A1/A2). Genotypic frequencies expected under Hardy-Weinberg equilibrium revealed a high rate of heterozygosity (47%) that strongly supports the hypothesis that E. granulosus s.s. (G1) is predominantly outbreeding. Comparative sequence analyses of the complete p29 gene showed that phylogenetic relationships within the genus Echinococcus were in agreement with those of previous nuclear gene studies. At the protein level, the deduced P29 amino acid (AA) sequences exhibited a high level of conservation, ranging from 97.9% AA sequence identity among the whole E. granulosus s.l. group to 99.58% identity among E. multilocularis isolates. We showed that P29 proteins of these two species differ by three AA substitutions without implication for antigenicity. In Western-blot analyses, serum antibodies from a human CE patient infected with E. canadensis (G6) strongly reacted with recombinant P29 from E. granulosus s.s. (G1) (recEg(G1)P29). In the same line, human anti-Eg(G1)P29 antibodies bound to recEcnd(G6)P29. Thus, minor AA sequence variations appear not to impair the prognostic serological use of P29.
High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

Background Metastatic melanoma is an untreatable cancer lacking reliable and non-invasive markers of disease progression. Exosomes are small vesicles secreted by normal as well as tumor cells. Human tumor-derived exosomes are involved in malignant progression and we evaluated the presence of exosomes in plasma of melanoma patients as a potential tool for cancer screening and follow-up. Methodology/Principal Findings We designed an in-house sandwich ELISA (Exotest) to capture and quantify exosomes in plasma based on expression of housekeeping proteins (CD63 and Rab-5b) and a tumor-associated marker (caveolin-1). Western blot and flow cytometry analysis of exosomes were used to confirm the Exotest-based findings. The Exotest allowed sensitive detection and quantification of exosomes purified from human tumor cell culture supernatants and plasma from SCID mice engrafted with human melanoma. Plasma levels of exosomes in melanoma-engrafted SCID mice correlated to tumor size. We evaluated the levels of plasma exosomes expressing CD63 and caveolin-1 in melanoma patients (n = 90) and healthy donors (n = 58). Consistently, plasma exosomes expressing CD63 (504±315) or caveolin-1 (619±310) were significantly increased in melanoma patients as compared to healthy donors (223±125 and 228±102, respectively). While the Exotest for CD63+ plasma exosomes had limited sensitivity (43%) the Exotest for detection of caveolin-1+ plasma exosomes showed a higher sensitivity (68%). Moreover, caveolin-1+ plasma exosomes were significantly increased with respect to CD63+ exosomes in the patients group. Conclusions/Significance We describe a new non-invasive assay allowing detection and quantification of human exosomes in plasma of melanoma patients. Our results suggest that the Exotest for detection of plasma exosomes carrying tumor-associated antigens may represent a novel tool for clinical management of cancer patients.
An experimental study of minimum routing cost spanning tree algorithms

The task of finding the Minimum Routing Cost Spanning Tree (MRCST) can be found in many network design problems. In general cases, MRCST problem is a NP-hard problem. Till now, several algorithms for solving the problem are proposed and their performance were evaluated on different data sets. This paper presents a short survey of well known MRCST algorithms and gives a report on an extensive experimentation based on benchmark instances collected from the literature. In addition, the paper is also the first pioneering research that experiment on graphs with up to 1000 vertices.
Boundedness of linear operators via atoms on Hardy spaces with non-doubling measures

Abstract Let μ be a non-negative Radon measure on which satisfies only the polynomial growth condition. Let 𝒴 be a Banach space and H 1(μ) be the Hardy space of Tolsa. In this paper, the authors prove that a linear operator T is bounded from H 1(μ) to 𝒴 if and only if T maps all (p, γ)-atomic blocks into uniformly bounded elements of 𝒴; moreover, the authors prove that for a sublinear operator T bounded from L 1(μ) to L 1, ∞(μ), if T maps all (p, γ)-atomic blocks with p ∈ (1, ∞) and γ ∈ ℕ into uniformly bounded elements of L 1(μ), then T extends to a bounded sublinear operator from H 1(μ) to L 1(μ). For the localized atomic Hardy space h 1(μ), the corresponding results are also presented. Finally, these results are applied to Calderón–Zygmund operators, Riesz potentials and multilinear commutators generated by Calderón–Zygmund operators or fractional integral operators with Lipschitz functions to simplify the existing proofs in the related papers.
Efficient Verification of Hazard-Freedom in Gate-Level Timed Asynchronous Circuits

This paper presents an efficient method for verifying hazard-freedom in gate-level timed asynchronous circuits. Timed circuits are a class of asynchronous circuits that are optimized using explicit timing information. In asynchronous circuits, correct operation requires that there are no hazards in the circuit implementation. Therefore, when designing an asynchronous circuit, each internal node and output of the circuit must be verified for hazard-freedom to ensure correct operation. Current verification algorithms for timed circuits require an explicit state exploration that often results in state explosion for even modest-sized examples. The goal of this paper is to abstract the behavior of internal nodes and utilize this information to make a conservative determination of hazard-freedom for each node in the circuit. Experimental results indicate that this approach is substantially more efficient than existing timing verification tools. These results also indicate that this method scales well for large examples that could not be previously analyzed, in that it is capable of analyzing these circuits in less than a second. While this method is conservative in that some false hazards may be reported, our results indicate that their number is small
Hypertension, Cardiovascular Episodes And Lipid Profile In Living Kidney Donors In Poland - Single Centre Experience

Background. The long-term risk of hypertension and cardiovascular disease in living kidney donors in Poland remains uncertain. Hypertension is one of the most important causes of cardiovascular disease worldwide. The objective of the study was to evaluate hypertension, cardiovascular disease and lipid profile in living kidney donors after open nephrectomies which were performed between 1995 and 2005 in our institution.
Retroperitoneal and mediastinal follicular dendritic cell sarcoma: report of 3 cases with review of literature

Follicular dendritic cell sarcoma (FDCS) is a rare malignant histiocytic proliferation of antigen presenting follicular dendritic cell. It is an uncommon primary malignancy first described by Monda et al. in 1986. Most commonly reported cases are lymph nodal. Occasional cases occur in extra nodal sites. Here, we describe the clinicopathological features, histomorphology and outcome of three patients with extranodal FDCS along with a concise review of literature on the topic. All three patients were adult females. Two patients were in third decade, and one had age of 50 years. Among the three cases, two cases are presented as retroperitoneal mass and one as mediastinal mass. CT scans revealed heterogeneously enhancing masses. All the cases showed ovoid to spindle neoplastic cells arranged predominantly in whorling, fascicular and storiform patterns with inflammatory infiltrate. Immunohistochemically, the tumor cells are positive for CD21, CD23, CD35 and Clustrin. In view of rarity and variable clinical presentation in FDCS, accurate diagnosis is necessary. Copyright © 2015 John Wiley & Sons, Ltd.
The semantics of Scheme control-flow analysis

This is a follow-on to my 1988 PLDI paper, "Control-Row Analysis in Scheme" [9]. I use the method of abstract semantic interpretations to explicate the control-flow analysis technique presented in that paper. I begin with a denotational semantics for CPS Scheme. I then present an alternate semantics that precisely expresses the control-flow analysis problem. I abstract this semantics in a natural way, arriving at two different semantic interpretations giving approximate solutions to the flow analysis problem, each computable at compile time. The development of the final abstract semantics provides a clear, formal description of the analysis technique presented in "Control-How Analysis in Scheme. " This research was supported in part by the Office of Naval Research and in part by the Defense Advanced Research Projects Agency (DOD), monitored by the Office of Naval Research under Contract N00014-84-K-0415, ARPA Order No. 5404. The views and conclusions contained in this document are those of the author and should not be interpreted as representing the official policies, either expressed or implied, of ONR, DARPA or the U.S. government.
Kinetics of IL-23 and IL-12 Secretion in Response to Toxoplasma gondii Antigens from THP-1 Monocytic Cells

IL-23 and IL-12 are structurally similar and critical for the generation of efficient cellular immune responses. Toxoplasma gondii induces a strong cell-mediated immune response. However, little is known about IL-23 secretion profiles in T. gondii-infected immune cells in connection with IL-12. We compared the patterns of IL-23 and IL-12 production by THP-1 human monocytic cells in response to stimulation with live or heat-killed T. gondii tachyzoites, or with equivalent quantities of either T. gondii excretory/secretory proteins (ESP) or soluble tachyzoite antigen (STAg). IL-23 and IL-12 were significantly increased from 6 hr after stimulation with T. gondii antigens, and their secretions were increased with parasite dose-dependent manner. IL-23 concentrations were significantly higher than those of IL-12 at the same multiplicity of infection. IL-23 secretion induced by live parasites was significantly higher than that by heat-killed parasites, ESP, or STAg, whereas IL-12 secretion by live parasite was similar to those of ESP or STAg. However, the lowest levels of both cytokines were at stimulation with heat-killed parasites. These data indicate that IL-23 secretion patterns by stimulation with various kinds of T. gondii antigens at THP-1 monocytic cells are similar to those of IL-12, even though the levels of IL-23 induction were significantly higher than those of IL-12. The detailed kinetics induced by each T. gondii antigen were different from each other.
Physicians' recommendations for mammography: do tailored messages make a difference?

OBJECTIVES Message tailoring, based on individual needs and circumstances, is commonly used to enhance face-to-face patient counseling. Only recently has individual tailoring become feasible for printed messages. This study sought to determine whether printed tailored recommendations addressing women's specific screening and risk status and perceptions about breast cancer and mammography are more effective than standardized printed recommendations. METHODS Computer-assisted telephone interviews were conducted with 435 women, aged 40 to 65 years, who had visited family practice groups within the previous 2 years. Subjects were randomly allocated to receive individually tailored or standardized mammography recommendation letters mailed from physicians to patients' homes. Follow-up interviews were conducted 8 months later. RESULTS Tailored letter recipients were more likely to remember and to have read more of their letters than standardized version recipients. After controlling for baseline status, tailored letter receipt was associated with more favorable follow-up mammography status for women with incomes below $26,000 and for Black women. CONCLUSIONS Tailored messages are a more effective medium for physicians' mammography recommendations; tailoring may be especially important for women of low socioeconomic status.
A Diverse Group of Previously Unrecognized Human Rhinoviruses Are Common Causes of Respiratory Illnesses in Infants

Background Human rhinoviruses (HRVs) are the most prevalent human pathogens, and consist of 101 serotypes that are classified into groups A and B according to sequence variations. HRV infections cause a wide spectrum of clinical outcomes ranging from asymptomatic infection to severe lower respiratory symptoms. Defining the role of specific strains in various HRV illnesses has been difficult because traditional serology, which requires viral culture and neutralization tests using 101 serotype-specific antisera, is insensitive and laborious. Methods and Findings To directly type HRVs in nasal secretions of infants with frequent respiratory illnesses, we developed a sensitive molecular typing assay based on phylogenetic comparisons of a 260-bp variable sequence in the 5' noncoding region with homologous sequences of the 101 known serotypes. Nasal samples from 26 infants were first tested with a multiplex PCR assay for respiratory viruses, and HRV was the most common virus found (108 of 181 samples). Typing was completed for 101 samples and 103 HRVs were identified. Surprisingly, 54 (52.4%) HRVs did not match any of the known serotypes and had 12–35% nucleotide divergence from the nearest reference HRVs. Of these novel viruses, 9 strains (17 HRVs) segregated from HRVA, HRVB and human enterovirus into a distinct genetic group (“C”). None of these new strains could be cultured in traditional cell lines. Conclusions By molecular analysis, over 50% of HRV detected in sick infants were previously unrecognized strains, including 9 strains that may represent a new HRV group. These findings indicate that the number of HRV strains is considerably larger than the 101 serotypes identified with traditional diagnostic techniques, and provide evidence of a new HRV group.
Adaptive Model-Based Decomposition of Polarimetric SAR Covariance Matrices

Previous model-based decomposition techniques are applicable to a limited range of vegetation types because of their specific assumptions about the volume scattering component. Furthermore, most of these techniques use the same model, or just a few models, to characterize the volume scattering component in the decomposition for all pixels in an image. In this paper, we extend the model-based decomposition idea by creating an adaptive model-based decomposition technique, allowing us to estimate both the mean orientation angle and a degree of randomness for the canopy scattering for each pixel in an image. No scattering reflection symmetry assumption is required to determine the volume contribution. We examined the usefulness of the proposed decomposition technique by decomposing the covariance matrix using the National Aeronautics and Space Administration/Jet Propulsion Laboratory Airborne Synthetic Aperture Radar data at the C-, L-, and P-bands. The randomness and mean orientation angle maps generated using our adaptive decomposition significantly improve the physical interpretation of the scattering observed at the three different frequencies.
Validating Age-Related Functional Imaging Changes in Verbal Working Memory with Acute Stroke

Functional imaging studies consistently find that older adults recruit bilateral brain regions in cognitive tasks that are strongly lateralized in younger adults, a characterization known as the Hemispheric Asymmetry Reduction in Older Adults model. While functional imaging displays what brain areas are active during tasks, it cannot demonstrate what brain regions are necessary for task performance. We used behavioral data from acute stroke patients to test the hypothesis that older adults need both hemispheres for a verbal working memory task that is predominantly left-lateralized in younger adults. Right-handed younger (age ≥ 50, n = 7) and older adults (age > 50, n = 21) with acute unilateral stroke, as well as younger (n = 6) and older (n = 13) transient ischemic attack (TIA) patients, performed a self-paced verbal item-recognition task. Older patients with stroke to either hemisphere had a higher frequency of deficits in the verbal working memory task compared to older TIA patients. Additionally, the deficits in older stroke patients were mainly in retrieval time while the deficits in younger stroke patients were mainly in accuracy. These data suggest that bihemispheric activity is necessary for older adults to successfully perform a verbal working memory task.
Rank modulation for flash memories

We explore a novel data representation scheme for multi-level flash memory cells, in which a set of n cells stores information in the permutation induced by the different charge levels of the individual cells. The only allowed charge-placement mechanism is a dasiapush-to-the-toppsila operation which takes a single cell of the set and makes it the top-charged cell. The resulting scheme eliminates the need for discrete cell levels, as well as overshoot errors, when programming cells. We present unrestricted Gray codes spanning all possible n-cell states and using only dasiapush-to-the-toppsila operations, and also construct balanced Gray codes. We also investigate optimal rewriting schemes for translating arbitrary input alphabet into n-cell states which minimize the number of programming operations.