Miracle-dz/UniFAR-FTUs huggingface dataset:
Truly Optimal Euclidean Spanners

Euclidean spanners are important geometric structures, having found numerous applications over the years. Cornerstone results in this area from the late 80s and early 90s state that for any d-dimensional n-point Euclidean space, there exists a (1+ε) -spanner with O(nε^-d+1) edges and lightness (normalized weight) O(ε^-2d)^1. Surprisingly, the fundamental question of whether or not these dependencies on ε and d for small d can be improved has remained elusive, even for d = 2. This question naturally arises in any application of Euclidean spanners where precision is a necessity (thus ε is tiny). In the most extreme case ε is inverse polynomial in n, and then one could potentially improve the size and lightness bounds by factors that are polynomial in n. The state-of-the-art bounds O(nε^-d+1) and O(ε^-2d) on the size and lightness of spanners are realized by the greedy spanner. In 2016, Filtser and Solomon [25] proved that, in low dimensional spaces, the greedy spanner is “near-optimal''; informally, their result states that the greedy spanner for dimension d is just as sparse and light as any other spanner but for dimension larger by a constant factor. Hence the question of whether the greedy spanner is truly optimal remained open to date. The contribution of this paper is two-fold. 1) We resolve these longstanding questions by nailing down the exact dependencies on ε and d and showing that the greedy spanner is truly optimal. Specifically, for any d= O(1), ε = Ω(n^-1/d-1): • We show that any (1+ε) -spanner must have Ω(nε^-d+1) edges, implying that the greedy (and other) spanners achieve the optimal size. • We show that any (1+ε) -spanner must have lightness Ω(ε^-d), and then improve the upper bound on the lightness of the greedy spanner from O(ε^-2d) to Õ_ε (ε^-d). 2) We then complement our negative result for the size of spanners with a rather counterintuitive positive result: Steiner points lead to a quadratic improvement in the size of spanners! Our bound for the size of Steiner spanners is tight as well (up to lower-order terms).
State of the art and emerging drug therapies for female infertility

Abstract At present, infertility is a key-issue. When applicable, in vitro fertilization (IVF) has become the standard approach to treat this condition but a thorough investigation and, whenever possible, the individual diagnosis of the underlying causes of infertility are required. For many female causes, indeed, efficient medical therapies are available to achieve a fast solution of the problem. This review is based on the relevant literature indexed in PubMed and SCOPUS and is focused on the most recent clinical literature on the treatment of women (and couples) affected from infertility. The reduction in IVF treatment burden and risks are now considered pivotal to set ‘patient-friendly’ therapies and represent crucial issues for both patients and physicians. To this end, the researchers are now focusing their attention on old drugs with new indications and new compounds with more appropriate functions, to improve the compliance of the women and reduce the burden of infertility, a condition that is becoming an important issue in the modern world, also for the Public Health System.
A Computational Account of the Role of Cochlear Nucleus and Inferior Colliculus in Stabilizing Auditory Nerve Firing for Auditory Category Learning

It is well known that auditory nerve (AN) fibers overcome bandwidth limitations through the volley principle, a form of multiplexing. What is less well known is that the volley principle introduces a degree of unpredictability into AN neural firing patterns that may be affecting even simple stimulus categorization learning. We use a physiologically grounded, unsupervised spiking neural network model of the auditory brain with spike time dependent plasticity learning to demonstrate that plastic auditory cortex is unable to learn even simple auditory object categories when exposed to the raw AN firing input without subcortical preprocessing. We then demonstrate the importance of nonplastic subcortical preprocessing within the cochlear nucleus and the inferior colliculus for stabilizing and denoising AN responses. Such preprocessing enables the plastic auditory cortex to learn efficient robust representations of the auditory object categories. The biological realism of our model makes it suitable for generating neurophysiologically testable hypotheses.
Dietary intake of young twins: nature or nurture?

Background: The early years in life are increasingly recognized as a critical period for the development of diet-related behavioral traits. However, discussions continue on the relative role of genes and the environment in determining dietary intake, particularly in young children for whom detailed dietary information is limited. Objectives: This study tested the hypothesis that diet in early childhood is primarily determined by the environment rather than by genes. A secondary aim was to characterize the early childhood diet. Design: A classic twin design used 3-d dietary data collected at age 21 mo from the Gemini cohort. From the full sample of 2402 families with twins, dietary diaries were available for 1216 twin pairs (384 monozygotic and 832 dizygotic pairs) after exclusions. Intakes of macronutrients, food, and beverages were estimated. Twin analyses quantified the contributions of genetic and environmental factors to population variation in intake. Results: At age 21 mo, children consumed small portions of a wide range of family foods. The shared environment was the predominant determinant, contributing between 66% (95% CI: 52%, 77%; milk-based desserts) and 97% (95% CI: 95%, 98%; juice) of the variation in intake. Genetic factors were estimated to account for between 4% (95% CI: 0%, 10%; savory snacks) and 18% (95% CI: 14%, 23%; bread) of dietary intake variation. Conclusion: Shared environmental influences are the predominant drivers of dietary intake in very young children, indicating the importance of factors such as the home food environment and parental behaviors.
Multi-Objectives Optimization of Ventilation Controllers for Passive Cooling in Residential Buildings

An inappropriate indoor climate, mostly indoor temperature, may cause occupants’ discomfort. There are a great number of air conditioning systems that make it possible to maintain the required thermal comfort. Their installation, however, involves high investment costs and high energy demand. The study analyses the possibilities of limiting too high a temperature in residential buildings using passive cooling by means of ventilation with ambient cool air. A fuzzy logic controller whose aim is to control mechanical ventilation has been proposed and optimized. In order to optimize the controller, the modified Multiobjective Evolutionary Algorithm, based on the Strength Pareto Evolutionary Algorithm, has been adopted. The optimization algorithm has been implemented in MATLAB®, which is coupled by MLE+ with EnergyPlus for performing dynamic co-simulation between the programs. The example of a single detached building shows that the occupants’ thermal comfort in a transitional climate may improve significantly owing to mechanical ventilation controlled by the suggested fuzzy logic controller. When the system is connected to the traditional cooling system, it may further bring about a decrease in cooling demand.
Shopping Cart Abandonment in Online Shopping

Shopping cart abandonment in online shopping is a growing concern for retailers because it represents lost sales. This study looks at perceived risk and perceived ownership in relation to shopping cart abandonment. It is hypothesized that perceived risk in intended behavior will affect actual purchase behavior and perceived ownership in intended behavior will positively affect perceived ownership in actual behavior. It is believed that decreasing risk will also decrease cart abandonment and increasing ownership will increase transaction completion therefore decreasing cart abandonment. A survey was administered and results showed that the most common perceived risk in abandoning the cart was financial risk. Results showed that there was a significant correlation between perceived ownership in intended behavior and actual purchase behavior however, 33% of the respondents indicated that they were likely to abandon the cart even with a sense of ownership.
Multi-Level of Feature Extraction and Classification for X-Ray Medical Image

There has been a rise in demand for digitized medical images over the last two decades. Medical images' pivotal role in surgical planning is also an essential source of information for diseases and as medical reference as well as for the purpose of research and training. Therefore, effective techniques for medical image retrieval and classification are required to provide accurate search through substantial amount of images in a timely manner. Given the amount of images that are required to deal with, it is a non-viable practice to manually annotate these medical images. Additionally, retrieving and indexing them with image visual feature cannot capture high level of semantic concepts, which are necessary for accurate retrieval and effective classification of medical images. Therefore, an automatic mechanism is required to address these limitations. Addressing this, this study formulated an effective classification for X-ray medical images using different feature extractions and classification techniques. Specifically, this study proposed pertinent feature extraction algorithm for X-ray medical images and determined machine learning methods for automatic X-ray medical image classification. This study also evaluated different image features (chiefly global, local, and combined) and classifiers. Consequently, the obtained results from this study improved results obtained from previous related studies.
Electroconvulsive therapy and clozapine in adolescents with schizophrenia spectrum disorders: is it a safe and effective combination?

OBJECTIVE To evaluate the safety and effectiveness of the combination of electroconvulsive therapy (ECT) and clozapine compared to ECT with other antipsychotics or benzodiazepines in a sample of adolescents diagnosed with schizophrenia spectrum disorders. METHODS Data regarding 28 adolescent subjects aged 13 to 18 with diagnoses of schizophrenia spectrum disorders according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision and treated with ECT were retrospectively collected. Twelve subjects were also treated with clozapine and 16 with other antipsychotics or benzodiazepines during ECT course and follow-up. Electroconvulsive therapy parameters and adverse effects were assessed using a systematic protocol. Positive and Negative Syndrome Scale and Clinical Global Impression scores before ECT and after acute ECT, and rate of rehospitalization during 1-year follow-up were used to assess effectiveness. Response was defined as a 20% decrease in Positive and Negative Syndrome Scale scores. RESULTS No differences were observed in the mean charge needed to induce seizure and electroencephalographic duration, but there was a slight difference in the current used. The nonclozapine group showed greater restlessness and agitation, although no differences were found in other adverse effects. The percentage of responders was similar: 66.7% in the clozapine group and 68.8% in the nonclozapine group. However, the rate of rehospitalization was lower in the patients treated with clozapine during 1-year follow-up (7.1%) compared to that of the nonclozapine group (58.3%) (P = 0.009). CONCLUSIONS The main findings of this study were that combining ECT with clozapine, compared to ECT with other antipsychotics or benzodiazepines, was safe and that both treatments were equally effective. Charges needed to induce seizure were similar in both groups. Patients treated with clozapine during 1-year follow-up had a lower rate of rehospitalization.
Cystic Meningiomas: Correlation between Radiologic and Histopathologic Features

Background Tumors with cysts often correlate with gliomas, metastatic tumors, or hemangioblastomas, which require differentiation. Methods Thirty-eight cases of cyst associated-meningioma based on preoperative radiologic studies and histologic confirmations were reviewed from November 1998 to July 2017. Results A total of 395 cases of meningioma were observed in the 20 years, and surgical treatment of intracranial meningioma was performed in 120 cases. Thirty-eight (9.6%) cases of cyst associated meningiomas were analyzed. Nauta type I was the most common type of cyst (39.5%) and the most frequent histopathological subtype was meningothelial type (36.8%). Conclusion Statistically there were no significant associations between meningioma histopathological type and associated cysts; however, the rate of World Health Organization grade II was higher in cyst associated meningiomas than in unrelated meningiomas. This correlation was weak, in accordance with the meningioma grade.
Antibiotic Prophylaxis in Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Background Recent meta-analyses concluded that antibiotic prophylaxis is not warranted in low-risk laparoscopic cholecystectomy. However, most trials in the meta-analyses had a relatively small sample size and were statistically underpowered. In addition, many of the trials mentioned potential cost savings owing to the elimination of prophylactic antibiotics. However, no trial has statistically estimated the cost effectiveness. To evaluate the results of meta-analyses, we conducted a randomized controlled trial on the role of prophylactic antibiotics in low-risk laparoscopic cholecystectomy with an adequate sample size. Methods From March 2007 to May 2013, at the Department of Surgery, Kansai Medical University, patients who were scheduled for elective laparoscopic cholecystectomy were randomly assigned to one of two arms: those who were and were not administered prophylactic antibiotics. The primary endpoint was the occurrence of postoperative infections and secondary endpoints were postoperative hospital stay and medical costs. Findings During the study period, 518 patients were assigned to the Antibiotics group and 519 to the No antibiotics group. Occurrences of surgical site infections, distant infections and overall infections were significantly lower in the Antibiotics group than in the No antibiotics group (0.8 vs. 3.7%, p = 0.001, OR: 0.205 (95%CI: 0.069 to 0.606); 0.4 vs. 3.1%, p = 0.0004, OR: 0.122 (95%CI: 0.028 to 0.533); 1.2 vs. 6.7%; p<0.0001, OR: 0.162 (95%CI: 0.068 to 0.389), respectively). The postoperative hospital stay was significantly shorter in the Antibiotics group (mean, SD: 3.69±1.56 vs. 4.07±3.00; p = 0.01) and the postoperative medical costs were significantly lower in the Antibiotics group (mean, SD: $766±341 vs. 832±670; p = 0.047). Multivariable analysis showed that independent risk factors for postoperative infectious complications were no prophylactic antibiotics (p<0.0001) and age 65 or older (p = 0.006). Conclusions Perioperative administration of prophylactic antibiotics should be recommended in laparoscopic cholecystectomy to prevent postoperative infectious complications and to reduce medical costs. Trial Registration UMIN Clinical Trials Registry UMIN000003749.
Relative Complications and Trends of Outpatient Total Shoulder Arthroplasty.

Outpatient arthroplasty is an appealing option among select patient populations as a mechanism for reducing health care expenditure. The purpose of this study was to determine the nationwide trends and complication profile of outpatient total shoulder arthroplasty (TSA). The authors reviewed a national administrative claims database to identify patients undergoing TSA as outpatients and inpatients from 2007 to 2016. The incidence of perioperative surgical and medical complications was determined by querying for relevant International Classification of Diseases, Ninth Revision, and Current Procedural Terminology codes. Multivariate logistic regression adjusted for age, sex, and Charlson Comorbidity Index was used to calculate odds ratios of complications among outpatients relative to inpatients undergoing TSA. The query identified 1555 patients who underwent outpatient TSA and 15,987 patients who underwent inpatient TSA. The median age was in the 70 to 74 years age group in both the outpatient and the inpatient cohorts, and the age distribution was comparable between the 2 cohorts (P=.287). The incidence of both outpatient (P<.001) and inpatient (P<.001) TSA increased during the study period. On adjustment for age, sex, and comorbidities, patients undergoing outpatient TSA had significantly lower rates of stiffness requiring manipulation under anesthesia (outpatient, 1.09%; inpatient, 2.35%; odds ratio, 0.52; 95% confidence interval, 0.38-0.71; P<.001) and higher rates of postoperative surgical site infections requiring reoperation (outpatient, 0.90%; inpatient, 0.65%; odds ratio, 1.65; 95% confidence interval, 1.15-2.35; P<.001) at 1 year. Rates of all other postoperative complications were comparable. Ambulatory TSA is increasing in incidence nationwide and is associated with an overall favorable postoperative complication profile. [Orthopedics. 2018; 41(3):e400-e409. ].
Incidence rate of community-acquired pneumonia in adults: a population-based prospective active surveillance study in three cities in South America

Objective To determine the incidence rate and mortality of community-acquired pneumonia (CAP) in adults in three cities in Latin America during a 3-year period. Design Prospective population-based surveillance study. Setting Healthcare facilities (outpatient centres and hospitals) in the cities of General Roca (Argentina), Rivera (Uruguay) and Concepción (Paraguay). Participants 2302 adults aged 18 years and older with CAP were prospectively enrolled between January 2012 and March 2015. Main outcome measures Incidence rates of CAP in adults, predisposing conditions for disease, mortality at 14 days and at 1 year were estimated. Incidence rate of CAP, within each age group, was calculated by dividing the number of cases by the person-years of disease-free exposure time based on the last census; incidence rates were expressed per 1000 person-years. Results Median age of participants was 66 years, 46.44% were men, 68% were hospitalised. Annual incidence rate was 7.03 (95% CI 6.64 to 7.44) per 1000 person-years in General Roca, 6.33 (95% CI 5.92 to 6.78) per 1000 person-years in Rivera and 1.76 (95% CI 1.55 to 2.00) per 1000 person-years in Concepción. Incidence rates were highest in participants aged over 65 years. 82.4% had at least one predisposing condition and 48% had two or more (multimorbidity). Chronic heart disease (43.6%) and smoking (37.3%) were the most common risk factors. 14-day mortality rate was 12.1% and 1-year mortality was 24.9%. Multimorbidity was associated with an increased risk of death at 14 days (OR 2.91; 95% CI 2.23 to 3.80) and at 1 year (OR 3.00; 95% CI 2.44 to 3.70). Conclusions We found a high incidence rate of CAP in adults, ranging from 1.76 to 7.03 per 1000 person-years, in three cities in South America, disclosing the high burden of disease in the region. Efforts to improve prevention strategies are needed.
Adverse Childhood Experiences and Amygdalar Reduction: High-Resolution Segmentation Reveals Associations With Subnuclei and Psychiatric Outcomes

The aim of the present study was 2-fold: (1) to utilize improved amygdala segmentation and exploratory factor analysis to characterize the latent volumetric structure among amygdala nuclei and (2) to assess the effect of adverse childhood experiences (ACEs) on amygdalar morphometry and current psychiatric symptoms. To investigate these aims, structural (T1) MRI and self-report data were obtained from 119 emerging adults. Regression analysis showed that higher ACE scores were related to reduced volume of the right, but not the left, amygdalar segments. Further, exploratory factor analysis yielded a two-factor structure, basolateral and central-medial nuclei of the right amygdala. Stractual equation modeling analyses revealed that higher ACE scores were significantly related to a reduced volume of the right basolateral and central-medial segments. Furthermore, reduction in the right basolateral amygdala was associated with increased anxiety, depressive symptoms, and alcohol use. This association supports an indirect effect between early adversity and psychiatric problems via reduced right basolateral amygdalar volume. The high-resolution segmentation results reveal a latent structure among amygdalar nuclei, which is consistent with prior work conducted in nonhuman mammals. These findings extend previous reports linking early adversity, right amygdala volume, and psychopathology.
Simplifying subsidiary theory : statistical evidence from Arabic , Muna , Shona , and Wargamay

Subsidiary features modulate the degree to which the Obligatory Contour Principle on place (OCP-Place) is violated by homorganic consonants. Statistical analysis of consonant cooccurrence patterns in four unrelated languages, combined with a method of model comparison that incorporates Occam’s Razor, support a theory in which each place and subsidiary feature has a weight that contributes to gradient OCP-Place violation. Crucially, the weights of subsidiary features are not free to vary across place of articulation within a language. This weighted feature theory is more restrictive than the alternative proposed by Coetzee and Pater 2008b, which allows subsidiary features to vary in weight both across languages and across places within a language (an approach that has its roots in the non-quantitative theories of Yip 1989; Padgett 1991, 1995; McCarthy 1994). The weighted feature theory is less restrictive than the natural classes model of Frisch et al. 2004, but the greater descriptive freedom provided by language-particular weighting is motivated by the data even when Occam’s Razor is taken into account. In addition to arguing for a novel theory of subsidiary features, this paper demonstrates that the method of evaluating analyses of co-occurrence data with respect to Observed/Expected (O/E) values — as originally proposed by Pierrehumbert 1993 and adopted by several recent papers in NLLT (Frisch et al. 2004, Coetzee and Pater 2008b, Anttila 2008, Coon and Gallagher 2008) — is mathematically flawed, as it confounds co-occurrence restrictions with positional probabilities. The main empirical claim of Coetzee and Pater 2008b, namely that correlations with the data of Arabic and Muna uniformly favor their weightedconstraint theory over that of Frisch et al. 2004, is based on the problematic O/E method and must be qualified. An alternative, statistically sound method of model evaluation and comparison based on probability theory is introduced and shown to support the weighted feature theory of OCP-Place over the alternatives considered. Acknowledgments. We would like to thank Rahul Balusu, Luigi Burzio, Jenny Culbertson, Lisa Davidson, Jason Eisner, Bruce Hayes, Matt Goldrick, Kyle Rawlins, Paul Smolensky, Kie Zuraw, and the participants of the Linguistics colloquium at Yale and the the CLSP seminar at Johns Hopkins for helpful feedback. We are grateful to Andries Coetzee and Stefan Frisch for making data from Muna and Arabic available to us. Bruce Hayes deserves special acknowledgment for his role in the development of the grammatical framework that we adopt, as well as for making versions of the Shona and Wargamay data publicly accessible.