Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of sacral nerve stimulation for urinary retention: results 18 months after implantation.

PURPOSE We investigate the efficacy of sacral neurostimulation in patients with idiopathic urinary retention in a prospective, randomized multicenter trial. MATERIALS AND METHODS A total of 177 patients with urinary retention refractory to standard therapy were enrolled in the study. Greater than 50% improvement in baseline voiding symptoms during a 3 to 7-day percutaneous test stimulation qualified a patient for surgical implantation of an InterStim parallel system. Of the patients who qualified for implantation 37 were randomly assigned to a treatment and 31 to a control group. Patients in the treatment group underwent early surgical implantation of the sacral nerve stimulation system, while implantation was delayed in the control group for 6 months. Followup evaluations, including voiding diary analysis and temporary deactivation of the stimulator at 6 months, were conducted at 1, 3, 6, 12 and 18 months after implantation in the treatment group, and after 3 and 6 months in the control group. RESULTS Compared to the control group, patients implanted with the InterStim system had statistically and clinically significant reductions in the catheter volume per catheterization (p <0.0001). Of the patients treated with implants 69% eliminated catheterization at 6 months and an additional 14% had a 50% or greater reduction in catheter volume per catheterization. Therefore, successful results were achieved in 83% of the implant group with retention compared to 9% of the control group at 6 months. Temporary inactivation of sacral nerve stimulation therapy resulted in a significant increase in residual volumes (p <0.0001) but effectiveness of sacral nerve stimulation was sustained through 18 months after implant. CONCLUSIONS Results of this prospective, randomized clinical study demonstrate that sacral nerve stimulation is effective for restoring voiding in patients with retention who are refractory to other forms of treatment.
Distribution, Fraction, and Ecological Assessment of Heavy Metals in Sediment-Plant System in Mangrove Forest, South China Sea

Overlying water, sediment, rhizosphere sediment and mangrove seedlings in the Futian mangrove forest were analyzed for heavy metals. The results showed that mangrove plant acidified sediment and increased organic matter contents. Except for chromium (Cr), nickel (Ni) and copper (Cu) in Aegiceras corniculatum sediment, heavy metals in all sediments were higher than in overlying water, rhizosphere sediment and mangrove root. Heavy metals in Avicennia marina sediments were higher than other sediments. The lower heavy metal biological concentration factors (BCFs) and translocation factors (TFs) indicated that mangrove plant adopted exclusion strategy. The geo-accumulation index, potential ecological risk index and risk assessment code (RAC) demonstrated that heavy metals have posed a considerable ecological risk, especially for cadmium (Cd). Heavy metals (Cr, Ni, Cu and Cd) mainly existed in the reducible fractions. These findings provide actual heavy metal accumulations in sediment-plant ecosystems in mangrove forest, being important in designing the long-term management and conservation policies for managers of mangrove forest.
Effects of Self-Correction Strategy Training on Middle School Students' Self-Efficacy, Self-Evaluation, and Mathematics Division Learning

Teachers need to monitor students' self-efficacy judgments, as well as their mathematics learning, to provide optimal instruction. First, inaccuracies in self-judgments appear to be a major liability for elementary and middle school children. Classroom practice must cultivate the knowledge to succeed and should nurture the belief that one can succeed. Second, accuracy training can be incorporated in a curriculum. After students solve the problems, teachers can show them how well they judged their capability to solve the problems. Students who can assess what they know and do not know will become better self-regulated learners. Third, strategy training in mathematics is very important. Students learn various strategies in school to solve mathematics problems, but they may not apply the strategies if they do not see their value. Teachers need to show the connection between strategy training and self-efficacy judgments and how these psychological variables relate to better mathematics performance. Students who utilize strategies in problem solving will develop higher efficacy compared to those who do not utilize them. Fourth, accurate self-reflection is important to students' success in math. Teachers can help students to hone this invaluable self-regulatory skill by giving them frequent opportunities to evaluate what they have learned or where they erred after completing a task. Students' self-efficacy is strengthened with tangible indicators of progress. Finally, unrealistically low self-efficacy beliefs and not lack of ability or skill may be responsible for avoidance of challenging academic courses such as math. Teachers will have to identify these inaccurate judgments and design and implement appropriate interventions to change them.
Examining the Effects of Conformal Terrain Features in Advanced Head‐Up Displays on Flight Performance and Pilot Situation Awareness

Synthetic vision systems (SVS) render terrain features for pilots through cockpit displays using a GPS database and three‐dimensional graphical models. Enhanced vision systems (EVS) present infrared imagery of terrain using a forward‐looking sensor in the nose of an aircraft. The ultimate goal of SVS and EVS technologies is to support pilots in achieving safety under low‐visibility and night conditions comparable to clear, day conditions. This study assessed pilot performance and situation awareness (SA) effects of SVS and EVS imagery in an advanced head‐up display (HUD) during a simulated landing approach under instrument meteorological conditions. Videos of the landing with various HUD configurations were presented to eight pilots with a superimposed tracking task. The independent variables included four HUD feature configurations (baseline [no terrain imagery], SVS, EVS, and a combination of SVS and EVS), two visibility conditions, and four legs of the flight. Results indicated that SVS increased overall SA but degraded flight path control performance because of visual confusion with other display features. EVS increased flight path control accuracy but decreased system (aircraft) awareness because of visual distractions. The combination of SVS and EVS generated offsetting effects. Display configurations did not affect pilot spatial awareness. Flight performance was not different among phases of the approach, but levels and types of pilot SA did vary from leg to leg. These results are applicable to development of adaptive HUD features to support pilot performance. They support the use of multidimensional measures of SA for insight on pilot information processing with advanced aviation displays. © 2012 Wiley Periodicals, Inc.
Modulation of Insulin Sensitivity of Hepatocytes by the Pharmacological Downregulation of Phospholipase D

Background. The role of phospholipase D (PLD) as a positive modulator of glucose uptake activation by insulin in muscle and adipose cells has been demonstrated. The role of PLD in the regulation of glucose metabolism by insulin in the primary hepatocytes has been determined in this study. Methods. For this purpose, we studied effects of inhibitors of PLD on glucose uptake and glycogen synthesis stimulation by insulin. To determine the PLD activity, the method based on determination of products of transphosphatidylation reaction, phosphatidylethanol or phosphatidylbutanol, was used. Results. Inhibition of PLD by a general antagonist (1-butanol) or specific inhibitor, halopemide, or N-hexanoylsphingosine, or by cellular ceramides accumulated in doxorubicin-treated hepatocytes decreased insulin-stimulated glucose metabolism. Doxorubicin-induced hepatocytes resistance to insulin action could be abolished by inhibition of ceramide production. Halopemide could nullify this effect. Addition of propranolol, as well as inhibitors of phosphatidylinositol 3-kinase (PI3-kinase) (wortmannin, LY294002) or suppressors of Akt phosphorylation/activity, luteolin-7-O-glucoside or apigenin-7-O-glucoside, to the culture media could block cell response to insulin action. Conclusion. PLD plays an important role in the insulin signaling in the hepatocytes. PLD is activated downstream of PI3-kinase and Akt and is highly sensitive to ceramide content in the liver cells.
Detecting significant change in neuropsychological test performance: A comparison of four models

A major use of neuropsychological assessment is to measure changes in functioning over time; that is, to determine whether a difference in test performance indicates a real change in the individual or just chance variation. Using 7 illustrative test measures and retest data from 384 neurologically stable adults, this paper compares different methods of predicting retest scores, and of determining whether observed changes in performance are unusual. The methods include the Reliable Change Index, with and without correction for practice effect, and models based upon simple and multiple regression. For all test variables, the most powerful predictor of follow-up performance was initial performance. Adding demographic variables and overall neuropsychological competence at baseline significantly but slightly improved prediction of all follow-up scores. The simple Reliable Change Index without correction for practice performed least well, with high error rates and large prediction intervals (confidence intervals). Overall prediction accuracy was similar for the other three methods; however, different models produce large differences in predicted scores for some individuals, especially those with extremes of initial test performance, overall competency, or demographics. All 5 measures from the Halstead–Reitan Battery had residual (observed − predicted score) variability that increased with poorer initial performance. Two variables showed significant nonnormality in the distribution of residuals. For accurate prediction with smallest prediction–confidence intervals, we recommend multiple regression models with attention to differential variability and nonnormality of residuals. (JINS, 1999, 5, 357–369.)
Mindfulness online: a preliminary evaluation of the feasibility of a web-based mindfulness course and the impact on stress

Objectives Stress has been shown to have a number of negative effects on health over time. Mindfulness interventions have been shown to decrease perceived stress but access to interventions is limited. Therefore, the effectiveness of an online mindfulness course for perceived stress was investigated. Design A preliminary evaluation of an online mindfulness course. Participants This sample consisted of 100 self-referrals to the online course. The average age of participants was 48 years and 74% were women. Interventions The online programme consisted of modules taken from Mindfulness Based Stress Reduction and Mindfulness Based Cognitive Therapy and lasted for approximately 6 weeks. Primary and secondary outcome measures Participants completed the Perceived Stress Scale (PSS) before the course, after the course and at 1-month follow-up. Completion of formal (eg, body scan, mindful movement) and informal (eg, mindful meal, noticing) mindfulness activities was self-reported each week. Results Participation in the online mindfulness course significantly reduced perceived stress upon completion and remained stable at follow-up. The pre-post effect size was equivalent to levels found in other class-based mindfulness programmes. Furthermore, people who had higher PSS scores before the course reported engaging in significantly more mindfulness practice, which was in turn associated with greater decreases in PSS. Conclusions Because perceived stress significantly decreased with such limited exposure to mindfulness, there are implications for the accessibility of mindfulness therapies online. Future research needs to evaluate other health outcomes for which face-to-face mindfulness therapies have been shown to help, such as anxiety and depressive symptoms.
Periodontal regeneration in class III furcation defects of beagle dogs using guided tissue regenerative therapy with platelet-derived growth factor.

We developed an effective regenerative therapy, referred to as platelet-derived growth factor-BB (PDGF-BB)-modulated guided tissue regenerative (GTR) therapy (P-GTR), capable of achieving periodontal regeneration of horizontal (Class III) furcation defects in the beagle dog. To determine its efficacy, repair and regeneration of horizontal furcation defects by P-GTR therapy and GTR therapy were compared. Chronically inflamed horizontal furcation defects were created around the second (P2) and fourth mandibular premolars (P4). After demineralization of the root surfaces with citric acid, the surfaces of left P2 and P4 were treated with PDGF-BB (P-GTR therapy) and those of contralateral teeth were treated with vehicle only (GTR therapy). Periodontal membranes were placed and retained 0.5 mm above the cemento-enamel junction for both groups. The mucoperiosteal flap was sutured in a coronal position and plaque control was achieved by daily irrigation with 2% chlorhexidine gluconate. At 5, 8, and 11 weeks, two animals each were sacrificed by perfusion with 2.5% glutaraldehyde through the carotid arteries, and the lesions were sliced mesio-distally, demineralized, dehydrated, and embedded. Periodontal healing and regeneration after GTR and P-GTR therapy were compared by histomorphometric as well as morphological analysis. Morphometric analysis for each time period was performed on the pooled samples of P2 and P4. Five weeks after both therapies, the lesions were filled primarily by tissue-free area, epithelium, inflamed tissue, and a small amount of newly formed fibrous connective tissue. At 8 and 11 weeks after P-GTR therapy, there was a statistically greater amount of bone and periodontal ligament formed in the lesions. The newly formed bone filled 80% of the lesion at 8 weeks and 87% at 11 weeks with P-GTR therapy, compared to 14% of the lesion at 8 weeks and 60% at 11 weeks with GTR therapy. Also, with P-GTR therapy there was less epithelium and tissue-free area, less inflamed tissue, and less connective tissue. Morphological analysis indicated that the defects around P2 revealed faster periodontal repair and regeneration than those around P4. While the lesions around P2 were effectively regenerated by 11 weeks even after GTR therapy, those around P4 failed to regenerate. On the other hand, P-GTR therapy further promoted periodontal repair and regeneration so that at 8 weeks the lesions around P2 and P4 demonstrated complete and nearly complete regeneration, respectively. (ABSTRACT TRUNCATED AT 400 WORDS)
Ursodeoxycholic acid–induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis

Ursodeoxycholic acid treatment of patients with primary biliary cirrhosis may lead to relief of pruritus and improvement of biochemical liver tests. The changes in serum and urinary bile acids induced by ursodeoxycholic acid treatment were studied. After 29 patients with primary biliary cirrhosis were treated with ursodeoxycholic acid (750 to 1,000 mg/day) for 6 to 12 mo because of an increase in ursodeoxycholic acid, total plasma bile acids increased from 30.5 ± 6 μmol/L (mean ± S.E.M.) to 52.7 ± 11.7 μmol/L (p < 0.01). The increase in total plasma bile acids correlated significantly with concentrations of plasma bile acid before treatment (p < 0.01). The concentrations of endogenous bile acids decreased, mainly because of a decrease of cholic acid. During treatment, glycine conjugation increased and taurine conjugation decreased, whereas sulfation and glucuronidation of bile acids were unchanged.
Angiotensinogen and Its Cleaved Derivatives Inhibit Angiogenesis

The members of the serine protease inhibitor (serpin) family, which share a common tertiary structure and a role as serin protease inhibitors, are involved in a variety of newly discovered functions. For example, antithrombin III exerts a strong antiangiogenic activity. Angiotensinogen, the renin substrate, has a folded structure and is a member of the noninhibitory serpin subfamily. Two other noninhibitory serpins, maspin and pigment epithelium-derived factor, have antiangiogenic properties. We investigated the antiangiogenic effect of angiotensinogen and 2 related compounds: (1) des(angiotensin I)angiotensinogen, the product of angiotensinogen cleavage by renin, and (2) the reactive center loop-cleaved angiotensinogen, which is produced after selective and limited proteolysis by the protease V8. We used well-established in vitro (endothelial cell proliferation and migration, and capillary-like tube formation on Matrigel) and in vivo (the chick chorioallantoic membrane assay) models of angiogenesis to evaluate the antiangiogenic activities of these 3 related molecules. Our data demonstrated that these compounds exerted a clear and equipotent antiangiogenic effect, thus attributing a novel function to angiotensinogen and des(angiotensin I)angiotensinogen, for which no function was previously known.
Studies on predictability of early graft function after liver transplantation

Liver transplantation has changed the future of patients with end-stage liver disease. Nowadays one year patient survival reaches 90% in experienced centers. Most patients die in the early phase after transplantation. After this initial period patient survival approximates survival curves of the healthy population. This thesis focuses on early graft function after orthotopic liver transplantation and the factors determining such function.
Three-Phase Unbalanced Power Flow Using a $\pi$-Model of Controllable AC-DC Converters

Microgrids are unique in that they can combine unbalanced three-phase systems with other AC and DC network sections, which may include a range of renewable energy sources, energy storage elements, and controllable AC-DC converters. Existing unbalanced power flow techniques such as the Ladder Iterative Technique and the three-phase Newton-Raphson (NR) method can analyze microgrids in sections but lack a complete system representation. Hence, there is a need for a power flow algorithm that considers the complete system model and solves it. A novel π-model of a controllable AC-DC converter and a single set of power balance equations for modeling a grid comprising multiple three-phase AC and DC sections is proposed. The π-model of a controllable AC-DC converter enables its inclusion into the network bus admittance matrix (YBUS) along with three-phase AC and DC network sections. Verification of the π-model is also described in the paper. The results of power flow studies with three-phase balanced and unbalanced AC and DC network sections are presented. The outcome of the π-model verification study and power flow study show that the proposed π-model is consistent and accurate. While the proposed model was developed for microgrids, it is applicable for all power system analysis applications.
Socio-Demographic Profile of Patients with Postmenopausal Bleeding Attending Out-Patient Unit of a Tertiary Care Centre

Postmenopausal bleeding accounts for 9-10% of gynecological complaints, and 10% of patients presenting with postmenopausal bleeding are diagnosed to have carcinoma endometrium. Certain socio-demographic characteristics of patients may delay the investigation to rule out such endometrial cancer risks. We aim to study the socio-demographic profile and other associated factors in women with postmenopausal bleeding attending out-patient unit of a tertiary care center in semirural area of Kerala. This is a descriptive study conducted among all women age ≥ 45 who attended the Gynecology out-patient department with complaints of post menopausal bleeding during the periodof December 2012 to November 2013. Significant association could be obtained between postmenopausal bleeding and socioeconomic status, parity, diabetes mellitus and body mass index.
The Melanopic Sensitivity Function Accounts for Melanopsin-Driven Responses in Mice under Diverse Lighting Conditions

In addition to rods and cones, photoreception in mammals extends to a third retinal cell type expressing the photopigment melanopsin. The influences of this novel opsin are widespread, ranging from pupillary and circadian responses to brightness perception, yet established approaches to quantifying the biological effects of light do not adequately account for melanopsin sensitivity. We have recently proposed a novel metric, the melanopic sensitivity function (VZλ), to address this deficiency. Here, we further validate this new measure with a variety of tests based on potential barriers to its applicability identified in the literature or relating to obvious practical benefits. Using electrophysiogical approaches and pupillometry, initially in rodless+coneless mice, our data demonstrate that under a very wide range of different conditions (including switching between stimuli with highly divergent spectral content) the VZλ function provides an accurate prediction of the sensitivity of melanopsin-dependent responses. We further show that VZλ provides the best available description of the spectral sensitivity of at least one aspect of the visual response in mice with functional rods and cones: tonic firing activity in the lateral geniculate nuclei. Together, these data establish VZλ as an important new approach for light measurement with widespread practical utility.
A Versatile Molecular Tagging Method for Targeting Proteins to Avian Reovirus muNS Inclusions. Use in Protein Immobilization and Purification

Background Avian reoviruses replicate in viral factories, which are dense cytoplasmic compartments estabilished by protein-protein interactions. The non-structural protein muNS forms the factory scaffold that attracts other viral components in a controlled fashion. To create such a three-dimensional network, muNS uses several different self-interacting domains. Methodology/Principal Findings In this study we have devised a strategy to identify muNS regions containing self-interacting domains, based on the capacity of muNS-derived inclusions to recruit muNS fragments. The results revealed that the muNS region consisting of residues 477–542 was recruited with the best efficiency, and this raised the idea of using this fragment as a molecular tag for delivering foreign proteins to muNS inclusions. By combining such tagging system with our previously established method for purifying muNS inclusions from baculovirus-infected insect cells, we have developed a novel protein purification protocol. Conclusions/Significance We show that our tagging and inclusion-targeting system can be a simple, versatile and efficient method for immobilizing and purifying active proteins expressed in baculovirus-infected cells. We also demonstrate that muNS inclusions can simultaneously recruit several tagged proteins, a finding which may be used to generate protein complexes and create multiepitope particulate material for immunization purposes.
Programming language support for multicast communication in distributed systems

A spectrum of abstractions for multicast communications is introduced in increasing order of both desirability and semantic level: functional mapping, iterators, and streams. Examples of distributed algorithms from the literature are used to illustrate the expressive power of each mechanism. Streams, in particular, provide first-class status for multicast communication in progress and can be implemented efficiently in typical multicast communication architectures. Related work and the criteria for multicast support are discussed. The layers of a typical distributed system that are relevant to language support for multicast communication are discussed. <<ETX>>