Miracle-dz/UniFAR-FTUs huggingface dataset:
Guidelines for schoolbag carriage: An appraisal of safe load limits for schoolbag weight and duration of carriage.

BACKGROUND There is no global agreement on a schoolbag weight limit and little assessment of its utility. The duration of carriage is another factor yet there is no previous systematic assessment of the utility of cut-off values for it in identifying schoolbag-related discomfort. OBJECTIVES The objectives were to establish if there was a threshold for musculoskeletal discomfort based on (i) percentage bodyweight (% BW) of the schoolbag; (ii) duration of carriage; or (iii) combined % BW and duration. METHODS Using data from 462 primary school children, a novel experimental approach was used to explore the utility of conventional schoolbag weight limit guidelines and duration of carriage. A receiver operating characteristic (ROC) curve was constructed to examine the predictive performance of schoolbag weight and duration of carriage. RESULTS The mean schoolbag weight (4.8±1.43 kg) represented a mean 12.4±4.18% BW. Only 30.7% of the sample carried schoolbags that were ≤10% BW. The majority (76%) carried schoolbags to school for ≤10 minutes. No % BW, duration of carriage or mechanical burden criterion provided a threshold cut-off point for accurately predicting schoolbag-related discomfort. CONCLUSIONS Guidelines for safe schoolbag carriage that are based on mechanical factors alone could not be upheld. The association between duration of carriage and back discomfort warrants further investigation.
Passive buoyant tracers in the ocean surface boundary layer: 2. Observations and simulations of microplastic marine debris

This paper is the second of a two-part series that investigates passive buoyant tracers in the ocean surface boundary layer (OSBL). The first part examines the influence of equilibrium wind-waves on vertical tracer distributions, based on large eddy simulations (LESs) of the wave-averaged Navier-Stokes equation. Motivated by observations of buoyant microplastic marine debris (MPMD), this study applies the LES model and the parametric one-dimensional column model from part one to examine the vertical distributions of MPMD. MPMD is widely distributed in vast regions of the subtropical gyres and has emerged as a major open ocean pollutant whose distribution is subject to upper ocean turbulence. The models capture shear-driven turbulence, Langmuir turbulence (LT), and enhanced turbulent kinetic energy input due to breaking waves (BWs). Model results are only consistent with observations of MPMD profiles and the relationship between surface concentrations and wind speed if LT effects are included. Neither BW nor shear-driven turbulence is capable of deeply submerging MPMD, suggesting that the observed vertical MPMD distributions are a characteristic signature of wave-driven LT. Thus, this study demonstrates that LT substantially increases turbulent transport in the OSBL, resulting in deep submergence of buoyant tracers. The parametric model is applied to 11 years of observations in the North Atlantic and North Pacific subtropical gyres to show that surface measurements substantially underestimate MPMD concentrations by a factor of 3–13.
Combined vascular resection and reconstruction for advanced hilar cholangiocarcinoma

Background: Hilar cholangiocarcinoma with vascular invasion was previously regarded as locally advanced disease and a contraindication to curative resection. The significance of combined vascular resection and reconstruction has remained ambiguous and controversial. This study aimed to reveal the role and efficacy of concomitant vascular resection and reconstruction on survival of patients with hilar cholangiocarcinoma. Materials and Methods: From January 2006 to December 2014, totally 19 out of 95 hilar cholangiocarcinoma patients undergoing curative resection were performed with combined vascular resection and reconstruction in a single institute including right hepatic artery alone (n=6), portal vein plus right hepatic artery (n=3) and portal vein alone (n=10), the remaining 67 patients underwent without vascular resection. The clinicopathologic features and survival outcomes of candidates were analyzed retrospectively. Results: The one, three and five-years survival rates in vascular reconstruction group were 78.8%, 21.3%, 0% respectively, comparing with that of non-vascular resection group 79.3%, 31.8%, 12.3% respectively (P=0.416). Median survival time in vascular reconstruction group was 17 months with mortality of 5.26% (1/19), which was close to that of non-vascular resection group. Pathological examination confirmed 36.84% patients (7/19) were with microscopic invasion. Multivariate analysis showed that CA-199 above 200 U/ml (P=0.035) and pathological differentiation (P=0.015) were independent prognostic factors of adverse effect on postoperative survival. Conclusion: Combined vascular resection and reconstruction for advanced hilar cholangiocarcinoma could improve survival with acceptable efficacy and safety in selected patients.
Effective site finding using link anchor information

Link-based ranking methods have been described in the literature and applied in commercial Web search engines. However, according to recent TREC experiments, they are no better than traditional content-based methods. We conduct a different type of experiment, in which the task is to find the main entry point of a specific Web site. In our experiments, ranking based on link anchor text is twice as effective as ranking based on document content, even though both methods used the same BM25 formula. We obtained these results using two sets of 100 queries on a 18.5 million document set and another set of 100 on a 0.4 million document set. This site finding effectiveness begins to explain why many search engines have adopted link methods. It also opens a rich new area for effectiveness improvement, where traditional methods fail.
MATHEMATICAL USES OF GAUGE THEORY

1.1. This article surveys some developments in pure mathematics which have, to varying degrees, grown out of the ideas of gauge theory in Mathematical Physics. The realisation that the gauge fields of particle physics and the connections of differential geometry are one and the same has had wide-ranging consequences, at different levels. Most directly, it has lead mathematicians to work on new kinds of questions, often shedding light later on well-established problems. Less directly, various fundamental ideas and techniques, notably the need to work with the infinite-dimensional gauge symmetry group, have found a place in the general world-view of many mathematicians, influencing developments in other fields. Still less direct, the work in this area—between geometry and mathematical physics—has been a prime example of the interaction between these fields which has been so fruitful over the past thirty years.
Weighing strategy for network localization under scarce ranging information

We propose a robust non-parametric strategy to weight scarce and imperfect ranging information, which is shown to significantly improve the accuracy of distance-based network localization algorithms. The proposed weights have a dispersion component, which captures the effect of noise under the assumption of bias-free samples, and a penalty component, which quantifies the risk of the latter assumption and penalizes it proportionally. The dispersion weights result from the application of small-scale statistics with confidence bounds optimized under a maximum entropy criterion that mathematizes the empirical concept of reliability commonly found in related literature. In turn, the penalty weights are derived from the relationship between the risk incurred by the bias-free assumption and the geometry of 3-node cliques, established by statistical-geometry. The performance of the distance-based network localization algorithm employing the proposed dispersion-penalty weights is compared against the Cramer-Rao lower bound (CRLB) and to equivalent algorithms employing alternative weights. The comparison reveals that, amongst the alternatives, the network localization algorithm with the proposed weights performs best and closest to an unbiased estimator.
Diet: A Scalable Toolbox to Build Network Enabled Servers on the Grid

Among existing grid middleware approaches, one simple, powerful, and flexible approach consists of using servers available in different administrative domains through the classical client-server or Remote Procedure Call (RPC) paradigm. Network Enabled Servers implement this model also called GridRPC. Clients submit computation requests to a scheduler whose goal is to find a server available on the grid. The aim of this paper is to give an overview of a middleware developed by the GRAAL team called DIET (for Distributed Interactive Engineering Tool-box). DIET is a hierarchical set of components used for the development of applications based on computational servers on the grid.
BCG vaccine in Korea

The anti-tuberculosis Bacille de Calmette et Guérin (BCG) vaccine was developed between 1905 and 1921 at Pasteur Institutes of Lille in France, and was adopted by many countries. BCG strains comprise natural mutants of major virulence factors of Mycobacterium tuberculosis and that BCG sub-strains differ markedly in virulence levels. The tuberculosis became endemic in Korea after the Korean War (1950s). The BCG strain, which was donated by Pasteur Institutes, was brought to Korea in 1955, and the first domestic BCG vaccine was produced by the National Defense Research Institute (NDRI), current Korea Centers for Disease Control and Prevention (KCDC), in 1960. Since 1987, BCG manufacture work was handed over to the Korean Institute of Tuberculosis (KIT), the freeze-dried BCG vaccine was manufactured at a scale required to meet the whole amount of domestic consumption. However, since 2006, the manufacture of BCG vaccine suspended and the whole amount of BCG was imported at this point of time. Now KIT is planning to re-produce the BCG vaccine in Korea under the supervision of KCDC, this will be render great role to National Tuberculosis Control Program (NTP) and provide initiating step for developing new tuberculosis vaccines in Korea.
Coronary flow reserve calculated from pressure measurements in humans. Validation with positron emission tomography.

BACKGROUND Experimental studies have shown that fractional flow reserve (defined as the ratio of maximal achievable flow in a stenotic area to normal maximal achievable flow) can be calculated from coronary pressure measurements only. The objectives of this study were to validate fractional flow reserve calculation in humans and to compare this information with that derived from quantitative coronary angiography. METHODS AND RESULTS Twenty-two patients with an isolated, discrete proximal or mid left anterior descending coronary artery stenosis and normal left ventricular function were studied. Relative myocardial flow reserve, defined as the ratio of absolute myocardial perfusion during maximal vasodilation in the stenotic area to the absolute myocardial perfusion during maximal vasodilation (adenosine 140 micrograms.kg-1 x min-1 intravenously during 4 minutes) in the contralateral normally perfused area, was assessed by 15O-labeled water and positron emission tomography (PET). Myocardial and coronary fractional flow reserve were calculated from mean aortic, distal coronary, and right atrial pressures recorded during maximal vasodilation. Distal coronary pressures were measured by an ultrathin, pressure-monitoring guide wire with minimal influence on the trans-stenotic pressure gradient. Minimal obstruction area, percent area stenosis, and calculated stenosis flow reserve were assessed by quantitative coronary angiography. There was no difference in heart rate, mean aortic pressure, or rate-pressure product during maximal vasodilation during PET and during catheterization. Percent area stenosis ranged from 40% to 94% (mean, 77 +/- 13%), myocardial fractional flow reserve from 0.36 to 0.98 (mean, 0.61 +/- 0.17), and relative flow reserve from 0.27 to 1.23 (mean, 0.60 +/- 0.26). A close correlation was found between relative flow reserve obtained by PET and both myocardial fractional flow reserve (r = .87) and coronary fractional flow reserve obtained by pressure recordings (r = .86). The correlations between relative flow reserve obtained by PET and stenosis measurements derived from quantitative coronary angiography were markedly weaker (minimal obstruction area, r = .66; percent area stenosis, r = -.70; and stenosis flow reserve, r = .68). CONCLUSIONS Fractional flow reserve derived from pressure measurements correlates more closely to relative flow reserve derived from PET than angiographic parameters. This validates in humans the use of fractional flow reserve as an index of the physiological consequences of a given coronary artery stenosis.
Immunohistochemical study of oestrogen receptors in 351 human thyroid glands.

INTRODUCTION It is well recognised that the pathogenesis of thyroid diseases is complex and different factors such as genetic factors, iodine deficiency, sex, age, radiation therapy in childhood, growth stimulating antibodies, and other epithelial growth factors can influence them. Epidemiological features of thyroid tumours and experimental evidence suggest that female sex hormones may exert effects on the thyroid gland and its neoplasms. This possibility was addressed by investigating the expression of oestrogen receptor protein in 351 thyroid lesions. METHODS The tissues from 351 human thyroid glands comprising 130 nodular goitres and 221 neoplastic lesions were used for the present immunohistochemical assessment of oestrogen receptor expression. RESULTS Incidence of oestrogen receptor positive cases were 24 percent (31/130) for nodular goitres, 22 percent (8/37) for follicular adenomas, 11 percent (2/18) for follicular carcinomas, 31 percent (37/119) for papillary carcinomas, zero percent (0/35) for medullary carcinomas and zero percent (0/12) for undifferentiated carcinomas. The incidence of oestrogen receptor positivity, which is compatible with other studies, is higher in well-differentiated thyroid lesions. The incidence of oestrogen receptor reactivity does not significantly differ between females and males of different age groups and it does not correlate with lymph node status, and vascular and capsular invasions. CONCLUSION The relatively high proportion of oestrogen receptor positivity in goitres, follicular adenomas and papillary carcinomas, compared with its reactivity in other thyroid neoplasms, and contrasted against normal thyroid tissue, suggests that the incidence of oestrogen receptor reactivity tends to increase with better differentiation of thyroid lesions. This finding may have clinical relevance.
Suction is kid's play: extremely fast suction in newborn seahorses

Ongoing anatomical development typically results in a gradual maturation of the feeding movements from larval to adult fishes. Adult seahorses are known to capture prey by rotating their long-snouted head extremely quickly towards prey, followed by powerful suction. This type of suction is powered by elastic recoil and requires very precise coordination of the movements of the associated feeding structures, making it an all-or-none phenomenon. Here, we show that newborn Hippocampus reidi are able to successfully feed using an extremely rapid and powerful snout rotation combined with a high-volume suction, surpassing that observed in adult seahorses. An inverse dynamic analysis shows that an elastic recoil mechanism is also used to power head rotation in newborn H. reidi. This illustrates how extreme levels of performance in highly complex musculoskeletal systems can be present at birth given a delayed birth and rapid development of functionally important structures. The fact that the head skeleton of newborn seahorses is still largely cartilaginous may not be problematic because the hydrodynamic stress on the rotating snout appeared considerably lower than in adult syngnathids.
Life course body size and lipid levels at 53 years in a British birth cohort

Objectives: To investigate the association between growth in height and change in body mass index (BMI) during the life course on lipid levels at 53 years. Methods: 2311 men and women from a British cohort study were included in analyses. Non-fasting total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels were measured at 53 years. Height and BMI at 2, 4, 7, 11, 15 and 36 years in relation to the lipid outcomes at 53 years were assessed using multiple regression models. The effects of z scores of height and BMI at 2 years and yearly rates of change (velocities) in height and BMI between 2–7, 7–15 and 15–36 years were also considered. Results: Total cholesterol level decreased by 0.119 mmol/l (95% CI –0.194 to –0.045) per SD increase in height at 2 years and by 0.073 mmol/l (95% CI –0.145 to –0.001) for every SD increase in height velocity between 15 years and adulthood. Similar, but weaker associations were seen for LDL cholesterol. The relationships between leg length and total and LDL cholesterol were stronger than the relationship with trunk length. Higher BMI at 36 and 53 years and greater BMI increases between 15–36 and 36–53 years were associated with higher total and LDL cholesterol and lower HDL cholesterol levels. The effects of growth could not be explained by birth weight or lifetime socioeconomic status. Conclusions: Early life exposures, which restrict height growth in infancy, resulting in shorter adult leg length, may influence lipid levels in adult life.
Spatio‐temporal dynamics of gene expression of the Edn1‐Dlx5/6 pathway during development of the lower jaw

The morphogenesis of the vertebrate skull results from highly dynamic integrated processes involving the exchange of signals between the ectoderm, the endoderm, and cephalic neural crest cells (CNCCs). Before migration CNCCs are not committed to form any specific skull element, molecular signals exchanged in restricted regions of tissue interaction are crucial in providing positional identity to the CNCCs mesenchyme and activate the specific morphogenetic process of different skeletal components of the head. In particular, the endothelin‐1 (Edn1)‐dependent activation of Dlx5 and Dlx6 in CNCCs that colonize the first pharyngeal arch (PA1) is necessary and sufficient to specify maxillo‐mandibular identity. Here, to better analyze the spatio‐temporal dynamics of this process, we associate quantitative gene expression analysis with detailed examination of skeletal phenotypes resulting from combined allelic reduction of Edn1, Dlx5, and Dlx6. We show that Edn1‐dependent and ‐independent regulatory pathways act at different developmental times in distinct regions of PA1. The Edn1→Dlx5/6→Hand2 pathway is already active at E9.5 during early stages of CNCCs colonization. At later stages (E10.5) the scenario is more complex: we propose a model in which PA1 is subdivided into four adjacent territories in which distinct regulations are taking place. This new developmental model may provide a conceptual framework to interpret the craniofacial malformations present in several mouse mutants and in human first arch syndromes. More in general, our findings emphasize the importance of quantitative gene expression in the fine control of morphogenetic events. genesis 48:362–373, 2010. © 2010 Wiley‐Liss, Inc.
The ABF1 factor is the transcriptional activator of the L2 ribosomal protein genes in Saccharomyces cerevisiae

The same factor, ABF1, binds to the promoters of the two gene copies (L2A and L2B) coding for the ribosomal protein L2 in Saccharomyces cerevisiae. In vitro binding experiments and in vivo functional analysis showed that the different affinities of the L2A and L2B promoters for the ABF1 factor are responsible for the differential transcriptional activities of the two gene copies. The presence of ABF1-binding sites in front of many housekeeping genes suggests a general role for ABF1 in the regulation of gene activity.
Capture and Amplification by Tailing and Switching (CATS)

Massive parallel sequencing (MPS) technologies have paved the way into new areas of research including individualized medicine. However, sequencing of trace amounts of DNA or RNA still remains a major challenge, especially for degraded nucleic acids like circulating DNA. This together with high cost and time requirements impedes many important applications of MPS in medicine and fundamental science. We have established a fast, cheap and highly efficient protocol called ‘Capture and Amplification by Tailing and Switching’ (CATS) to directly generate ready-to-sequence libraries for MPS from nanogram and picogram quantities of both DNA and RNA. Furthermore, those DNA libraries are strand-specific, can be prepared within 2–3 h and do not require preliminary sample amplification steps. To exemplify the capacity of the technique, we have generated and sequenced DNA libraries from hundred-picogram amounts of circulating nucleic acids isolated from human blood plasma, one nanogram of mRNA-enriched total RNA from cultured cells and few nanograms of bisulfite-converted DNA. The approach for DNA library preparation from minimal and fragmented input described here will find broad application in diverse research areas such as translational medicine including therapy monitoring, prediction, prognosis and early detection of various human disorders and will permit high-throughput DNA sequencing from previously inaccessible material such as minute forensic and archeological samples.
An Application of UTAUT2 on Social Recommender Systems: Incorporating Social Information for Performance Expectancy

The recently proposed extended Unified Theory of Acceptance and Use of Technology (UTAUT2) offers new opportunities for exploring the acceptance of consumer technologies. This study utilizes UTAUT2 to explore the user acceptance of social recommender systems that have become more attractive owing to improved content personalization and adaptation to user preferences. Scholars have shown that these systems could improve a recommendation's accuracy. However, the UTAUT2's applicability and the explanation of performance expectancy for social recommender systems are still unclear. We developed a UTAUT2-based framework and tested it in a quantitative study with 266 participants. The structural equation model results show that UTAUT2 is applicable in the context of social recommender systems. Furthermore, the user's social network information, profile information, and reading behavior positively influence performance expectancy and the intention to adopt a social recommender system. Therefore, incorporating social information might overcome the shortcomings of other classic recommender systems.