Miracle-dz/UniFAR-FTUs huggingface dataset:
Thermoresponsive iron oxide-polymer composite nanoparticles for multimodal cancer therapy.

Magnetic nanoparticles possess unique properties that make them attractive materials for biomedical applications, such as cancer therapy, current modalities of cancer therapy suffer from several drawbacks. Multimodal cancer therapy by simultaneous hyperthermia and chemotherapy can synergistically enhance the therapeutic efficacy compared to individual/sequential application of these techniques. In the current work, drug loaded thermoresponsive composite nanoparticles (CNP) were synthesized, characterized by transmission electron microscopy (TEM), x-ray diffraction (XRD), thermal gravimetric analysis (TGA), UV-visible spectroscopy (UV-Vis), vibrating sample magnetometry (VSM), modulated differential scanning calorimetry (MDSC) and dynamic light scattering (DLS) techniques. They were evaluated by in vitro and in vivo tests for multimodal cancer therapy applications. y-Fe203 as well as Fe3C>4 MNP were synthesized by wet chemical methods. CNP with a Fe3C>4 or y-Fe203 MNP core and thermoresponsive crosslinked poly-nisopropylacrylamide (PNIPAM) shell were synthesized by polymerization of monomers in a ferrofluid. CNP were loaded with the anti-cancer drug doxorubicin (dox). The MNP exhibited good magnetic properties which were preserved after coating with PNIPAM and loading of dox. Swollen dox loaded Fe304 CNP exhibited temperature dependent drug release, with an initial burst phase followed by slow release. The lower critical solution temperature (LCST) of the shell could be used ATTENTION: The Singapore Copyright Act applies to the use of this document. Nanyang Technological University Library
Electrospun PU/P(AMPS-GO) nanofibrous membrane with dual-mode hydrophobic–hydrophilic properties for protective clothing applications

Bi-functional nanofibrous membrane composed of polyurethane in one face and poly(2-acryloylamido-2-methylpropanesulfonic acid)-graphene oxide (PAMPS-GO) in another face has been fabricated using two opposite-nozzle electrospinning set-up. The effect of graphene oxide addition on morphology of PAMPS nanofibers and performance of membrane were investigated. Besides structure of graphene oxide layers, electrospun nanofibers were studied using TEM, X-ray, FTIR, and FE-SEM methods. To evaluate the nanofibrous membrane performance, their tensile strength, water vapor permeability, and contact angle were measured. An average diameter of 500 nm and 83 nm were obtained for PU and PAMPS nanofibers, respectively, through the optimized electrospinning process. Results show that PAMPS nanofiber diameters together with pore sizes of its mat decrease by increasing the graphene oxide content. Also, the dimensional stability of electrospun fibers against water vapor was strengthened in the presence of graphene oxide nanosheets. An improvement in tensile strength of PAMPS nanofibers was observed by the addition of graphene oxide up to 0.2 wt. %, while more addition caused a negative change. Studying water vapor permeability of PAMPS nanofibers showed that increasing the graphene oxide content, the water vapor permeability increases. However, it decreases by increasing the surface density of nanofibers. From a hydrophobic–hydrophilic perspective, an excellent dual-mode behavior on two opposite faces was observed that is already proper for water proof-breathable protective clothing and wound dressing applications.
Cardiovascular autonomic dysfunction in insomnia patients with objective short sleep duration

Two phenotypes have been proposed: insomnia with objective near‐normal sleep duration, related to increased psychological symptoms, and insomnia with objective short sleep duration, associated with cardiometabolic morbidity. Reduced heart rate variability has also been implicated in the pathophysiology of cardiometabolic disease; however, there are little data on whether cardiovascular function differs between patients with objective short sleep duration and near‐normal sleep duration. Participants (Mage = 49.9 ± 11.3 years; 62.8% female) were 180 adults with chronic insomnia (Mduration = 15.7 ± 13.6). Objective sleep duration was based on total sleep time averaged across two consecutive nights of polysomnography and subjective sleep duration was based on 2‐week sleep diaries. The sample was divided into two groups, with sleep duration shorter (polysomnography‐total sleep time: n = 46; sleep diary: n = 95) or equal/longer (polysomnography‐total sleep time: n = 134; sleep diary: n = 85) than 6 hr. Electrocardiogram data derived from polysomnography were used to obtain heart rate and heart rate variability during stage 2 (N2) and rapid eye movement sleep. Heart rate variability measures included absolute and normalized high‐frequency component, an index of parasympathetic activation, and the ratio of low‐ to high‐frequency (LF/HF ratio), an index of sympathovagal balance. After controlling for covariates (e.g., co‐morbidity), patients with objective short sleep duration had reduced high‐frequency (p < .05) and elevated low‐frequency/high‐frequency ratio (p = .036) and heart rate (p = .051) compared with patients with near‐normal sleep duration. No differences were observed between phenotypes when subjective sleep duration was used. Insomnia patients with objective short sleep duration showed significantly dampened parasympathetic activation and increased sympathovagal imbalance relative to their counterparts with near‐normal sleep duration. These findings highlight the importance of treating insomnia, as treatment may reduce the risk of cardiovascular disease.
A cross-sectional analysis examining the association between dieting behaviours and alcohol use among secondary school students in the COMPASS study

Background Unhealthy weight-control methods and problematic alcohol use appear linked, with individuals engaging in both behaviours at greater risk of adverse consequences. Most studies have been conducted among females and young adults, yet both dieting and binge drinking emerge at earlier stages of development. Moreover, gender differences are likely due to contrasting body ideals. This study investigated the co-occurrence of dieting and alcohol use among youth, focusing on varying weight goals in males and females, and meal skipping, as a form of food restriction. Methods Cross-sectional analyses were conducted in sample of 44 861 Grade 9-12 students from Year 2 (2013-14) of the COMPASS study. Results and conclusions The majority of females were trying to lose weight, while males tended to report efforts to gain and these two groups demonstrated the highest odds of alcohol use and binge drinking. Breakfast and lunch skipping predicted binge drinking and alcohol use in females, but only the former was related to drinking behaviour in males. Breakfast skipping rarely occurred for weight loss purposes, although more females reported this reason for missing meals than males. Results support hypothesized gender variations in weight goals and meal skipping, and differing associations with drinking behaviour.
Detection of bacterial biofilm in uterine of repeat breeder dairy cows

Objective: To determine the possibility of presence of bacterial biofilm in the uterus of repeat breeder cows and to evaluate the effect of mucolytic agent in cleanup of uterus from biofilm. Methods: Twenty repeat breeder cows were selected from a large commercial dairy farm near Shiraz, Fars province, southern Iran. Uterine secretion samples were collected before and after uterine lavage with dimethyl sulfoxide (DMSO) 10% solution and periodic acid Schiff (PAS) staining was used to detect bacterial biofilm in uterine samples. After sampling, all cows were treated with two doses of PGF2α and intrauterine infusion of Cefquinome sulphate. Artificial insemination (AI) was performed after that. Results: Bacterial biofilms were found in 12 out of 20 animals (60%) in the first sampling with sterile saline lavage (before DMSO) and in 7 cows (35%) after DMSO lavage. Fourteen cows (70%) became pregnant after AI. This evidence showed the presence of bacterial biofilm in the uterus of dairy cows for the first time. Although non-significant, decrease in biofilm detection after DMSO lavage may suggest the potential ability of mucolytic agent for cleaning the uterus from bacterial biofilm. Also, high pregnancy rate after antibiotic treatment in the present study might be attributed to improved effect of antibiotic following lavage of uterine by DMSO. Conclusions: These findings should be investigated in future researches with more sample size.
Safety and efficacy of photoselective vaporization of the prostate using the 180-W GreenLight XPS laser system in patients taking oral anticoagulants

Objective To evaluate the safety and efficacy of the 180-W GreenLight XPS laser system for the treatment of benign prostatic hyperplasia in patients taking oral anticoagulants. Methods All consecutive patients admitted for lower urinary tract symptoms associated with benign prostatic hyperplasia from November 2012 to October 2016 and who underwent photoselective vaporization of the prostate with the 180-W GreenLight XPS laser were included in the study. The perioperative outcomes examined were the operating time, laser time, energy usage, and duration of postoperative catheterization. Functional parameters (International Prostate Symptom Score, maximum urinary flow rate, and post-void residual urine volume), prostate volume, and serum prostate-specific antigen concentration were examined at baseline and 3 months. Perioperative complications, if any, were noted. Results All functional parameters (International Prostate Symptom Score, maximum urinary flow rate, and post-void residual urine volume) significantly improved from baseline to 3 months. A small number of patients experienced at least one minor adverse event. There was no difference in the rate of adverse events between patients who were and were not taking anticoagulants. Conclusions Photoselective vaporization with a 180-W laser is an efficacious and safe treatment for benign prostatic hyperplasia, even in patients taking anticoagulant medications.
Use of Platelet‐Rich Fibrin Membrane as a Palatal Bandage

Introduction: Free gingival grafting is one of the most common techniques used to increase the dimensions of keratinized tissue (KT). The palatal donor sites heal with secondary intention, require a longer time, and cause discomfort to patients. This case series describes the use of platelet-rich fibrin (PRF) membrane as a palatal bandage to cover donor sites. To the best of the authors’ knowledge, this is the first report that describes the use of PRF membrane as a palatal bandage.Case Series: Five patients requiring augmentation of KT are described in this case series. The palatal donor sites of four of these patients were covered with PRF membranes as a palatal bandage. The donor site of the fifth patient was allowed to heal in a conventional way without PRF membrane to evaluate the difference in healing. The healing was evaluated visually by hydrogen peroxide test at days 12, 13, 18, 19, 24, 25, 30, and 31. Palatal donor sites covered with PRF membranes demonstrated considerably faster healing compare.
Noninvasive molecular methods to identify live scarab larvae: an example of sympatric pest and nonpest species in New Zealand

Despite the negative impact that many scarab larvae have on agro‐ecosystems, very little attention has been paid to their taxonomy. Their often extremely similar morphological characteristics have probably contributed to this impediment, which has also meant that they are very difficult to identify in the field. Molecular methods can overcome this challenge and are particularly useful for the identification of larvae to enable management of pest species occurring sympatrically with nonpest species. However, the invasive collection of DNA samples for such molecular methods is not compatible with subsequent behavioural, developmental or fitness studies. Two noninvasive DNA sampling and DNA analysis methods suitable for the identification of larvae from closely related scarab species were developed here. Using the frass and larval exuviae as sources of DNA, field‐collected larvae of Costelytra zealandica (White) and Costelytra brunneum (Broun) (Scarabaeidae: Melolonthinae) were identified by multiplex PCR based on the difference in size of the resulting PCR products. This study also showed that small quantities of frass can be used reliably even 7 days after excretion. This stability of the DNA is of major importance in ecological studies where timeframes rarely allow daily monitoring. The approach developed here is readily transferable to the study of any holometabolous insect species for which morphological identification of larval stages is difficult.
Nonparametric and Semiparametric Estimation with Discrete Regressors

This paper presents and discusses procedures for estimating regression curves when regressors are discrete and applies them to semiparametric inference problems. We show that pointwise root-n-consistency and global consistency of regression curve estimates are achieved without employing any smoothing, even for discrete regressors with unbounded support. These results still hold when smoothers are used, under much weaker conditions than those required with continuous regressors. Such estimates are useful in semiparametric inference problems. We discuss in detail the partially linear regression model and shape-invariant modelling. We also provide some guidance on estimation in semiparametric models where continuous and discrete regressors are present. The paper also includes a Monte Carlo study.
Is elbow breadth a measure of frame size in non-Caucasian Populations? A study in low- and high-altitude Central-Asia Populations

The concept of frame size has not undergone a thorough evaluation in non-Caucasian populations. Using data from the Central Asia High Altitude Population (CAHAP) study, we tested whether: (1) the relationship between frame size and body composition is different in high-, medium- and low-altitude populations; (2) elbow breadth is a better index of frame size than biacromial and biiliac breadth; and (3) measures of frame size are associated with blood pressure, cholesterol and triglycerides. A number of 334 male subjects aged 33±10 years (mean±standard deviation) were selected from the CAHAP population (n=384) on the basis of the availability of breadth measurements. The subjects were 85 high-altitude Kirghizs, 105 medium-altitude Kazakhs, 79 low-altitude Kirghizs and 65 low-altitude Uighurs. A detailed anthropometric evaluation and blood pressure, cholesterol and trygliceride measurements were performed on all individuals. Among breadths, elbow had the lowest correlation with arm fat area, thigh fat area, calf fat area and the sum of trunk skinfolds (r≤⃒0.196, P<0.01). Even if elbow breadth did not have the highest correlation with muscularity indexes, its constantly lower association with adiposity indexes shows that it is a better measure of frame size than biacromial breadth and biiliac breadth. The relationship between frame size and body composition did not differ in high-, medium- and low-altitude subjects (P=not significant, analysis of co-variance). Only a weak association was present between breadths, blood pressure, cholesterol and triglycerides (r≤⃒0.230, P<0.01) and it was not influenced by altitude (P=not significant, analysis of co-variance). Elbow breadth was significantly correlated only with diastolic blood pressure (r=0.121, P<0.05). In conclusion: (1) the relationship between frame size and body composition is similar in high- and low-altitude populations; (2) elbow breadth is an index of frame size independent of altitude; and (3) elbow breadth is correlated with diastolic blood pressure, but this correlation is of doubtful biological relevance.
Ongoing mumps outbreak in Israel, January to August 2017

In Israel, 262 mumps cases were registered between 1 January and 28 August 2017 despite a vaccine coverage of ≥ 96%. The majority (56.5%) of cases were adolescents and young adults between 10 and 24 years of age. Nearly twice as many cases were reported in males than in females. Sequence information identified genotype G and suggested specific transmission chains in different religious communities, with the Muslim population in Jerusalem being most severely affected.
Longitudinal Tobacco Use Transitions Among Adolescents and Young Adults: 2014–2016

INTRODUCTION Among youth, the frequency and prevalence of using more than one tobacco (small cigar, cigarette, and hookah) or nicotine-containing product (e-cigarettes-ENDS) are changing. These shifts pose challenges for regulation, intervention, and prevention campaigns because of scant longitudinal data on the stability of use patterns in this changing product landscape. METHODS A nationally representative longitudinal survey of 15- to 21-year olds (n = 15,275) was used to describe transitions between never use, noncurrent use, and past 30-day use of combustible tobacco, e-cigarettes (ENDS), and dual use of both kinds of products. A multistate model was fit to observations collected every 6 months across 2.5 years to estimate the probability of transitions between states (TPs), the average time in state (sojourn time), and the effect of age on transitions. RESULTS Current state strongly predicted future state over time intervals of 1 year or less, but only weakly predicted future state at longer intervals: TP to noncurrent use was higher for ENDS-only than combustible-only users over a 6-month interval but was similar for both groups over a 2-year interval. Sojourn time was significantly longer for combustible-only (0.52 years) and dual use (0.55 years) than ENDS-only use (0.27 years); older youth were more likely than younger youth to stay combustible tobacco users or noncurrent users. CONCLUSIONS The dynamics of transitions between combustible tobacco products and ENDS in a population of youth and young adults suggest that policy and prevention efforts must consider the frequent changes and instability over a 1-year or less time period in use patterns among young people. IMPLICATIONS The study addresses an urgent need in public health for timely information on how youth and young adults use tobacco and nicotine products. We found that youth, particularly adolescents, moved frequently between using ENDS and combustible tobacco products either alone or together. Importantly, the utility of current-use states for predicting future use states declined for time horizons longer than 1 year. Our results demonstrate a need for caution in interpreting product transitions. Longitudinal data with frequent observations and coverage of a wide range of possible product types is required to fully characterize usage patterns in youth.
Lineage origin and expansion of a Neotropical migrant songbird after recent glaciation events

Birds of the Northern Hemisphere often harbour the genetic signature of postglaciation expansion but analyses identifying the location of refugia and the directionality of expansions are rare. Here we explore the evolutionary history of yellow warbler lineages, focusing on how these lineages recolonized their current range. We genotyped samples from 696 yellow warblers via direct sequencing of a 333‐bp control region I mitochondrial DNA fragment or lineage‐specific genotyping. Phylogenetic analysis revealed two monophyletic clades: a highly migratory group including previously identified eastern and western lineages and a less migratory group including a lineage consisting of tropical residents and a new ‘southern’ lineage localized in southwest United States. We then modelled the expansion of the eastern and western lineages, identified the location of potential refugia and assessed the importance of migration as a historical factor promoting gene flow. The expansion of the eastern lineage proceeded from a main refugia in the eastern United States, with possible contribution of an additional local refugia. In the western lineage, the expansion proceeded from a single refugia possibly located in western United States. Because two lineages overlapped to varying degrees in central North America, we suggest that the Canadian Prairies offered a bridge of riparian habitats where the lineages met after glacier retreat, while the US Central Great Plains acted as a barrier that limited secondary contact. Finally, gene flow was more important along the north–south axis of migration than away from it, suggesting spring migration played a role in the dispersal of lineages.
Higher-order Closed-form Solutions for Free Vibration of Laminated Composite and Sandwich Shells

Closed-form formulations of two-dimensional (2D) higher-order shear deformation theories (HOSTs) for the free vibration analysis of simply supported cross-ply laminated composite and sandwich doubly curved shells are presented. The formulation includes the Sander’s theory for doubly curved shells. Two of the HOSTs account for the effects of both transverse shear strains/stresses and the transverse normal strain/stress, while the third includes only the effects of transverse shear deformation. In these developments a realistic parabolic distribution of transverse shear strains through the shell thickness is assumed. The equations of motion are obtained using Hamilton’s principle. Solutions are obtained in closed-form using Navier’s technique and by solving the eigenvalue equations. Numerical results are presented for the natural frequencies of laminated composite and sandwich shallow shells. The closed-form solutions presented herein for laminated composite plates and shells are compared with the available 3D elasticity and analytical solutions and it is believed that the solutions for sandwich laminates using various higher-order displacement models will serve as benchmark in future.
Comparing Characteristics of Early-Onset Injection Drug Users to Those With Late-Onset Injection in Kermanshah, Iran

ABSTRACT Background: Characteristics and behaviors of early-onset injection drug users are under studied topics in Iran. This study aimed to identify and compare the demographic characteristics as well as the drug using behaviors of early-onset and late-onset injection drug users in Kermanshah, West Iran. Methods: In this cross-sectional study using snowball and convenience sampling, we recruited 450 people during the Fall of 2014 from two drop in centers in Kermanshah, Iran. We collected data through face-to-face interviews. Early-onset injection is defined as whether the person reported their first injection at 22 years of age or younger. Subsequently, late-onset injection is defined as 23 years of age or older. We compared the characteristics of the two groups through both univariate and multiple logistic analyses. Results: Overall, 54% (CI 95%: 44.3%, 62.2%) were early injectors. After controlling for low socioeconomic status, initiation of drug use at a young age, multiple drug use and methamphetamine use were all significantly associated with a higher likelihood of early-onset injection. Additionally, early-onset injection was associated with recent syringe borrowing (OR = 2.6, p = 0.001), recent syringe lending (OR = 1.4, p = 0.01), recent cooker sharing (OR = 3.2, p = 0.01) and injecting two or more times a day (OR = 2.2, p = 0.04). Conclusion: Early-onset injectors were more likely to report a lower socioeconomic status, initiation of first drug use at a younger age, using methamphetamine alongside polydrug use, and engaging in higher risk taking behaviors like borrowing needles. With these associations, the study emphasizes the need for drug-prevention programs to focus on the transition to injection drug use at younger ages.