Miracle-dz/UniFAR-FTUs huggingface dataset:
Low prevalence of risk factors for coronary heart disease in rural Tanzania.

A community-based survey was used to assess the prevalence of risk factors for coronary heart disease (CHD) in rural Tanzanians. In all, 8581 subjects (3705 men, 4876 women) aged > or = 15 years in eight villages in three regions in rural Tanzania representing a range of socioeconomic deprivation were studied. The main outcome measures were serum cholesterol and triglyceride level, blood pressure and prevalence of dyslipidaemia, hypertension, smoking, overweight, impaired glucose tolerance (IGT) and diabetes; as well as ECG changes. Mean serum cholesterol levels in men were 4.2, 3.4 and 3.7 mmol/l, and in women 4.4 3.6 and 3.9 mmol/l in Kilimanjaro, Morogoro and Mara regions respectively. In Kilimanjaro region 17.4% of men and 19.0% of women had values above 5.2 mmol/l compared with only 5.0% and 6.7% in Morogoro region and 4.8% and 6.9% respectively in Mara region. Systolic and diastolic blood pressures increased with age in both men and women in all three regions with the most marked increase in Kilimanjaro region and the smallest rise in Mara region. Mean age-adjusted values were highest in Kilimanjaro region (124/75 mm Hg, and 125/76 mm Hg in men and women respectively) and lowest in Mara region (120/70 mm Hg in men and 118/68 mm Hg in women). Hypertension was found in 6.6% of men and 7.5% of women in Kilimanjaro region, 3.3% and 4.7% in Morogoro, and 2.6% and 3.4% in Mara region. Cigarette smoking was found in 42.6% of men in Kilimanjaro region, 28.2% of Morogoro region and 8.6% in Mara region. Less than 4% of women smoked in all three regions. (ABSTRACT TRUNCATED AT 250 WORDS)
Vibration and Human Performance1

Vibration research is reviewed from the point of view of how this environmental stress affects different types of human performance capabilities. The oscillatory motions normally called vibration range from 1–30 Hz. , and the motion may be either sinusoidal or random. In terms of subjective discomfort, the lowest tolerance level for vibration occurs at about 5 Hz. , the frequency at which resonance of large body organs is most severe. Visual acuity is severely impaired by vibration frequencies in the range of 10–25 Hz. Manual tracking capability is most seriously affected by vibrations at 5 Hz. and below, as are other motor capacities. Tasks involving primarily central neural processes, such as reaction time, monitoring, and pattern recognition, are highly resistant to the effects of vibration.
Adapting Golog for Composition of Semantic Web Services

Motivated by the problem of automatically composing network accessible services, such as those on the World Wide Web, this paper proposes an approach to building agent technology based on the notion of generic procedures and customizing user constraint. We argue that an augmented version of the logic programming language Golog provides a natural formalism for automatically composing services on the Semantic Web. To this end, we adapt and extend the Golog language to enable programs that are generic, customizable and usable in the context of the Web. Further, we propose logical criteria for these generic procedures that define when they are knowledge self-sufficient and physically selfsufficient. To support information gathering combined with search, we propose a middle-ground Golog interpreter that operates under an assumption of reasonable persistence of certain information. These contributions are realized in our augmentation of a ConGolog interpreter that combines online execution of information-providing Web services with offline simulation of worldaltering Web services, to determine a sequence of Web Services for subsequent execution. Our implemented system is currently interacting with services on the Web.
Working memory and phonological awareness.

Phonological awareness, and working memory, as a component of phonological awareness, have been found to be highly correlated, not only with the acquisition of reading skills, but also with each other. Existing data does not address this aspect of emergent literacy in South African children, for whom bilingualism may impact on their levels of phonological awareness, and possibly working memory. This research study was designed and conducted in an attempt to identify the relationship between these two skills in a sample of seventy-nine South African Grade 1 children (mean age 86 months). The sample consisted of two language groups, namely first-language English (EL1), an opaque orthography (n=42) and second-language English with first-language one of the nine official African languages of South Africa (EL2), a transparent orthography (n=37). The primary aim was to examine the relationship between phonological awareness (comprising a sound categorisation task, a phoneme deletion task, and a syllable splitting task) and working memory (comprising a verbal short-term memory task, a visuo-spatial short-term memory task, a verbal working memory task and a visuo-spatial working memory task). A measure of non-verbal intelligence was included as a control. Separate analyses were run for the two language groups in order to draw a comparison between their performance on the tasks. Results generally supported existing literature that showed that the relationship between working memory and phonological awareness appears to be dependent on the depth of analysis of phonological awareness, which determines the level of demand made on working memory, yet the relationship differed between the language groups, indicating that the EL2 children draw more on general or apparently unrelated skills to conduct working memory and phonological awareness tasks. A secondary aim of this study was to explore the predictive power of firstly, the four memory skills on phonological awareness; secondly, the sound categorisation skills on phoneme deletion and finally, non-verbal intelligence on working memory. Results again differed between the language groups, suggesting that a broader range of working
Papillary serous carcinoma of the uterine cervix: a clinicopathologic study of 17 cases.

The clinical and pathologic features of 17 cases of papillary serous adenocarcinoma of the cervix (PSCC) were studied in women who ranged in age from 26 to 70 years. There was a bimodal age distribution, with one peak occurring before the age of 40 years and the second peak after the age of 65. The presenting symptoms were abnormal vaginal bleeding (11 patients), abnormal exfoliative cervical cytology (four patients), or watery vaginal discharge (two patients). On pelvic examination, eight patients had a polypoid or exophytic cervical mass and two patients had an ulcerated or indurated cervix; no abnormality was detected in seven patients. Two tumors were stage Ia, 12 were stage Ib, two were stage II, and one was stage III. Nine patients were treated by radical hysterectomy and one by simple hysterectomy; six of these patients received postoperative radiotherapy. The other patients received primary radiotherapy. On microscopic examination, all of the tumors had a complex papillary architecture with epithelial stratification and tufting. Six tumors were grade 2/3 and 11 were grade 3/3. All of the tumors had >10 mitotic figures per 10 high-power fields. An intense acute and chronic inflammatory infiltrate was typically present within the cores of the papillae and in areas of stromal invasion. Occasional psammoma bodies were present in three cases. Five of 12 tumors stained positively for p53, with six and nine of 12 tumors, respectively, immunoreactive for carcinoembryonic antigen and CA-125. Seven tumors were mixed with another histologic subtype of cervical adenocarcinoma, most commonly low-grade villoglandular adenocarcinoma. Fifteen patients were followed from 6 months to 11 years (mean 56 months). Six patients died of extensive metastases within 5 years of diagnosis; an additional patient experienced tumor recurrence with malignant ascites 2 years after diagnosis. The most common metastatic sites were pelvic and periaortic lymph nodes; other sites included cervical lymph nodes, lung, peritoneum, liver, and skin. Eight patients were alive without evidence of tumor at last follow-up. Age <65 years, stage >I, tumor size >2 cm, tumor invasion >10 mm, the presence of lymph node metastases, and elevation of serum CA-125 were associated with a poor prognosis. Tumor grade or composition (pure or mixed) did not correlate with patient outcome. Papillary serous adenocarcinoma of the cervix resembles microscopically its counterparts elsewhere in the female genital tract and peritoneum. The tumors can behave aggressively with supradiaphragmatic metastases and a rapidly fatal course when diagnosed at an advanced stage, but the outcome for patients with stage I tumors is similar to that of patients with cervical adenocarcinomas of the usual type.
Mechanism of Vitamin C Inhibition of Cell Death Induced by Oxidative Stress in Glutathione-depleted HL-60 Cells*

Vitamin C is a well known antioxidant whose precise role in protecting cells from oxidative challenge is uncertain. In vitro results have been confounded by pro-oxidant effects of ascorbic acid and an overlapping role of glutathione. We used HL-60 cells as a model to determine the precise and independent role of vitamin C in cellular protection against cell death induced by oxidative stress. HL-60 cells do not depend on glutathione to transport or reduce dehydroascorbic acid. Depletion of glutathione rendered the HL-60 cells highly sensitive to cell death induced by H2O2, an effect that was not mediated by changes in the activities of glutathione reductase, glutathione peroxidase, catalase, or superoxide dismutase. The increased sensitivity to oxidative stress was largely reversed when glutathione-depleted cells were preloaded with ascorbic acid by exposure to dehydroascorbic acid. Resistance to H2O2 treatment in cells loaded with vitamin C was accompanied by intracellular consumption of ascorbic acid, generation of dehydroascorbic acid, and a decrease in the cellular content of reactive oxygen species. Some of the dehydroascorbic acid generated was exported out of the cells via the glucose transporters. Our data indicate that vitamin C is an important independent antioxidant in protecting cells against death from oxidative stress.
A CMOS Colpitts VCO Using Negative-Conductance Boosted Technology

A circuit topology suitable for a low-voltage low-power Colpitts voltage-controlled oscillator (VCO) is presented in this paper. By employing inductors for a negative-conductance boosted structure, the dc power consumption of the Colpitts VCO can be effectively reduced. Based on the proposed architecture, the VCO fabricated in 0.18-μm CMOS exhibits a measured 1.3% tuning range around 30 GHz. Operating at a supply voltage of 1.0 V, the VCO core consumes 2.3-mW dc power, and the measured phase noise is -104.1 dBc/Hz at 1-MHz offset. Compared to the recently published 20 to 30-GHz 0.18-μm CMOS VCOs, this work achieves a reduced supply voltage, minimized dc power consumption, small chip size, superior figure-of-merit (FOM), and better figure-of-merit including the tuning range (FOMT). Formulas for considering the nonlinear characteristics of varactors and active devices are also presented, and the accuracy of predicting the VCO tuning curve is validated by measurement.
Influence of Reduction Promoters on Stability of Cobalt/γ-Alumina Fischer-Tropsch Synthesis Catalysts

This focused review article underscores how metal reduction promoters can impact deactivation phenomena associated with cobalt Fischer-Tropsch synthesis catalysts. Promoters can exacerbate sintering if the additional cobalt metal clusters, formed as a result of the promoting effect, are in close proximity at the nanoscale to other cobalt particles on the surface. Recent efforts have shown that when promoters are used to facilitate the reduction of small crystallites with the aim of increasing surface Co0 site densities (e.g., in research catalysts), ultra-small crystallites (e.g., <2–4.4 nm) formed are more susceptible to oxidation at high conversion relative to larger ones. The choice of promoter is important, as certain metals (e.g., Au) that promote cobalt oxide reduction can separate from cobalt during oxidation-reduction (regeneration) cycles. Finally, some elements have been identified to promote reduction but either poison the surface of Co0 (e.g., Cu), or produce excessive light gas selectivity (e.g., Cu and Pd, or Au at high loading). Computational studies indicate that certain promoters may inhibit polymeric C formation by hindering C-C coupling.
Device-to-Device Underlaid Cellular Networks under Rician Fading Channels

Using Device-to-device (D2D) communications in a cellular network is an economical and effective approach to increase the transmission data rate and extend the coverage. Nevertheless, the D2D underlaid cellular network is challenging due to the presence of inter-tier and intra-tier interferences. With necessarily lower antenna heights in D2D communication links, the fading channels are likely to contain strong line-of-sight components, which are different from the Rayleigh fading distribution in conventional two-tier heterogeneous networks. In this paper, we derive the success probability, spatial average rate, and area spectral efficiency performances for both cellular users and D2D users by taking into account the different channel propagations that they experience. Specifically, we employ stochastic geometry as an analysis framework to derive closed-form expressions for above performance metrics. Furthermore, to reduce cross-tier interferences and improve system performances, we propose a centralized opportunistic access control scheme as well as a mode selection mechanism. According to the analysis and simulations, we obtain interesting tradeoffs that depend on the effect of the channel propagation parameter, user node density, and the spectrum occupation ratio on the different performance metrics. This work highlights the importance of incorporating the suitable channel propagation model into the system design and analysis to obtain the realistic results and conclusions.
Efficacy and safety of atypical antipsychotic drugs (quetiapine, risperidone, aripiprazole and paliperidone) compared with placebo or typical antipsychotic drugs for treating refractory schizophrenia: overview of systematic reviews

ABSTRACT CONTEXT AND OBJECTIVE: According to some cohort studies, the prevalence of refractory schizophrenia (RS) is 20-40%. Our aim was to evaluate the effectiveness and safety of aripiprazole, paliperidone, quetiapine and risperidone for treating RS. METHODS: This was a critical appraisal of Cochrane reviews published in the Cochrane Library, supplemented with reference to more recent randomized controlled trials (RCTs) on RS. The following databases were searched: Medical Literature Analysis and Retrieval System Online (Medline) (1966-2009), Controlled Trials of the Cochrane Collaboration (2009, Issue 2), Embase (Excerpta Medica) (1980-2009), Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs) (1982-2009). There was no language restriction. Randomized controlled trials, systematic reviews and meta-analyses evaluating atypical antipsychotics for treating RS were included. RESULTS: Seven Cochrane systematic reviews and 10 additional RCTs were included in this review. The data generally showed minor differences between the atypical antipsychotics evaluated and typical antipsychotics, regarding improvement in disease symptoms, despite better adherence to treatment with atypical antipsychotics. Risperidone was specifically evaluated in patients with RS in one of the systematic reviews included, with favorable outcomes, but without definitive superiority compared with other drugs of proven efficacy, like amisulpride, clozapine and olanzapine. CONCLUSIONS: The findings underscore the difficulty in treating these patients, with high dropout rates and treatment patterns of modest improvement in assessments of effectiveness. Atypical antipsychotics have advantages over typical antipsychotics mainly through their better safety profile, which leads to better adherence to treatment. A combination of antipsychotics may also be an option for some refractory patients.
The rod pathway in the rabbit retina: a depolarizing bipolar and amacrine cell

Anatomical and electrophysiological techniques were combined to study the morphology, synaptic connections, and response properties of two neurons in the rod pathway of the rabbit retina: the rod bipolar cell and the narrow-field, bistratified (NFB) amacrine cell. Rod bipolars receive synaptic input from rod cells in the outer plexiform layer (OPL), where their dendrites end as central elements in the invaginating synapse of rod spherules. Their main synaptic output in the inner plexiform layer (IPL) is onto NFB amacrine cells and at least one other type of amacrine, which in turn feeds a reciprocal synapse back onto the bipolar endings. Rod bipolars, or a variety of them, respond to diffuse, white light stimulation with a transient-sustained depolarization dominated by rods; with high-intensity flashes, they generate a secondary depolarization at off, which is homologous to the rod aftereffect of horizontal cells, although opposite in polarity. NFB amacrine cells receive synaptic input from rod bipolars, cone bipolars, and other types of amacrine cells; they are presynaptic to ganglion cell dendrites and communicate via gap junctions with other processes, whose parent neuron has not yet been identified. They respond to light with a triphasic potential, characterized by a depolarizing transient at on, followed by a sustained plateau phase, and finally by a hyperpolarizing transient at off. Threshold of their responses is the same as in the depolarizing rod bipolars and saturation is reached with nearly the same stimulus intensity in both neurons. Furthermore, NFB amacrine cells exhibit a depolarizing rod aftereffect at the termination of high-intensity flashes. Thus, this amacrine cell type is inserted in series along the rod pathway in the rabbit retina and modulates the transfer of scotopic signals from rod bipolars to ganglion cells.
The Incidence of Dementia in England and Wales: Findings from the Five Identical Sites of the MRC CFA Study

Background Although incidence of dementia is known to vary between nations, variation within country has not been explored because most incidence studies are single site or have insufficient numbers to compare sites. Few countries have conducted multisite incidence studies in order to facilitate national comparisons. This study aims to provide robust measures of the variation of the incidence of dementia across sites within England and Wales and produce overall estimates by age and sex. Methods and Findings The Medical Research Council Cognitive Function and Ageing Study used identical methodology in five diverse sites across the United Kingdom, each with different risk patterns and mortality rates. Incidence has been estimated using likelihood-based methods between the first two waves of interviews. Incidence rates rise with age, particularly above the age of 75 y, from 7.4 (95% confidence interval, 3.6–16.1) per 1,000 person years at age 65–69 y to 84.9 (95% confidence interval, 63.0–107.8) per 1,000 person years at age 85 y and above. The rate of increase for both sexes is marked, and continues into the oldest age groups. Hence, it is estimated that approximately 180,000 new cases of dementia occur in England and Wales each year. There is no convincing evidence of variation across sites, and incidence rates do not reflect the variations in the prevalence of possible risk factors in these sites. Conclusion There is no evidence, within England and Wales, of variation in dementia incidence across sites. Dementia incidence rates do not tail off at the oldest ages.
Modeling Variability in Software Process Lines ?

Software process lines (SPrL) are families of related processes, built from a set of administrated software process elements in a prestablished fashion, similar to how software product lines (SPL) are built with software assets. In SPLs, variability is usually speci ed using feature models. As SPrLs manage particular kinds of process elements, namely tasks, roles and work products, we explore the feasibility and applicability of feature and orthogonal variability models for specifying variability in SPrLs. In this paper, we present the kinds of variabilities that are relevant in the context of SPrLs and we show how they may be speci ed with feature models and orthogonal variability models. We use use a simple requirements engineering process as a means for illustrating each issue.
Revealing humans’ sensorimotor functions with electrical cortical stimulation

Direct electrical stimulation (DES) of the human brain has been used by neurosurgeons for almost a century. Although this procedure serves only clinical purposes, it generates data that have a great scientific interest. Had DES not been employed, our comprehension of the organization of the sensorimotor systems involved in movement execution, language production, the emergence of action intentionality or the subjective feeling of movement awareness would have been greatly undermined. This does not mean, of course, that DES is a gold standard devoid of limitations and that other approaches are not of primary importance, including electrophysiology, modelling, neuroimaging or psychophysics in patients and healthy subjects. Rather, this indicates that the contribution of DES cannot be restricted, in humans, to the ubiquitous concepts of homunculus and somatotopy. DES is a fundamental tool in our attempt to understand the human brain because it represents a unique method for mapping sensorimotor pathways and interfering with the functioning of localized neural populations during the performance of well-defined behavioural tasks.
One-Shot Imitation Learning

Imitation learning has been commonly applied to solve different tasks in isolation. This usually requires either careful feature engineering, or a significant number of samples. This is far from what we desire: ideally, robots should be able to learn from very few demonstrations of any given task, and instantly generalize to new situations of the same task, without requiring task-specific engineering. In this paper, we propose a meta-learning framework for achieving such capability, which we call one-shot imitation learning. Specifically, we consider the setting where there is a very large set of tasks, and each task has many instantiations. For example, a task could be to stack all blocks on a table into a single tower, another task could be to place all blocks on a table into two-block towers, etc. In each case, different instances of the task would consist of different sets of blocks with different initial states. At training time, our algorithm is presented with pairs of demonstrations for a subset of all tasks. A neural net is trained that takes as input one demonstration and the current state (which initially is the initial state of the other demonstration of the pair), and outputs an action with the goal that the resulting sequence of states and actions matches as closely as possible with the second demonstration. At test time, a demonstration of a single instance of a new task is presented, and the neural net is expected to perform well on new instances of this new task. The use of soft attention allows the model to generalize to conditions and tasks unseen in the training data. We anticipate that by training this model on a much greater variety of tasks and settings, we will obtain a general system that can turn any demonstrations into robust policies that can accomplish an overwhelming variety of tasks. Videos available at this https URL .