Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential response to retinoic acid of Syrian hamster embryo fibroblasts expressing v-src or v-Ha-ras oncogenes

It has been shown that treatment of many but not all tumor cell lines with retinoids affects cell proliferation and expression of the transformed phenotype. To determine whether the response of the tumor cell to retinoids is influenced by specific oncogenes activated in the cell, we studied the action of these agents in the immortal, nontumorigenic Syrian hamster embryo cell lines DES-4 and 10W transfected with either v-Ha-ras or v-src oncogenes. In this paper we show that in transformed DES-4 cells expressing v-src, retinoic acid inhibited anchorage-independent growth, reduced saturation density, and inhibited the induction of ornithine decarboxylase by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. In contrast, retinoic acid enhances the expression of the transformed phenotype in DES-4-derived cells that express v-Ha-ras. In these cells retinoic acid increases the number and the average size of colonies formed in soft agar. Moreover, retinoic acid enhances ornithine decarboxylase activity and acts in a synergistic fashion with 12-O-tetradecanoylphorbol-13-acetate. These results indicate that oncogenes activated in cells can indeed influence the response of cells to retinoids. Retinoic acid does not appear to alter the levels of pp60src or p21ras proteins in these cells, suggesting that retinoic acid does not affect the synthesis of these oncogene products. Furthermore, retinoic acid does not affect the protein kinase activity of pp60src. Transformed cell lines derived from 10W cells responded differently, indicating that the presence of a specific oncogene is not the only factor determining the response to retinoids. Possible mechanisms by which retinoic acid may interfere with the expression of the oncogene products are discussed.
Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice.

OBJECTIVE Cell-matrix interactions regulate chondrocyte differentiation and survival. The alpha1beta1 integrin is a major collagen receptor that is expressed on chondrocytes. Mice with targeted inactivation of the integrin alpha1 gene (alpha1-KO mice) provide a model that can be used to address the role of cell-matrix interactions in cartilage homeostasis and osteoarthritis (OA) pathogenesis. METHODS Knee joints from alpha1-KO and wild-type (WT) BALB/c mice were harvested at ages 4-15 months. Knee joint sections were examined for inflammation, cartilage degradation, and loss of glycosaminoglycans (by Safranin O staining). Immunohistochemistry was performed to detect the distribution of alpha1 integrin, matrix metalloproteinases (MMPs), and chondrocyte apoptosis. RESULTS In WT mice, the alpha1 integrin subunit was detected in hypertrophic chondrocytes in the growth plate and in a subpopulation of cells in the deep zone of articular cartilage. There was a marked increase in alpha1-positive chondrocytes in the superficial and upper mid-zones in OA-affected areas in joints from old WT mice. The alpha1-KO mice showed more severe cartilage degradation, glycosaminoglycan depletion, and synovial hyperplasia as compared with the WT mice. MMP-2 and MMP-3 expression was increased in the OA-affected areas. In cartilage from alpha1-KO mice, the cellularity was reduced and the frequency of apoptotic cells was increased. These results suggest that the alpha1 integrin subunit is involved in the early remodeling process in OA cartilage. CONCLUSION Deficiency in the alpha1 integrin subunit is associated with an earlier deregulation of cartilage homeostasis and an accelerated, aging-dependent development of OA.
Pengaruh Informasi Asimetri dan Disclosure terhadap Cost of Capital

This study intends to identify the interactive effect of asymmetry information and disclosure on cost of capital. Data is selected using stratified random sampling. The analysis units are 72 companies registered on the Jakarta Stock Exchange in 1996. The data collection is performed using archival. The statistic method used to test the hypotheses, are multiple regression, multiplicative model and nonmonotonic effect. In addition, an analytical method of utilizing partial derivative to test the contingency relationship as advocated by Waterhouse dan Tiessen (1978); Schoonhoven (1978); Govindarajan (1986); Chia (1995); Fisher (1996); Botosan (1997), Nazaruddin (1998), and Mardiyah and Gudono (2001) is also used. The study results are as follows: first, The results provide support for the hypothesis that assymetry information and disclosure have an interactive effect on cost of capital. More specifically, the results show that disclosure significantly moderates the relationship between asymmetry information and cost of capital. The greater the degree of disclosure, the stronger the effect of low assymetry information on low cost of capital. Second, there are no differences among the available industries (i.e., service, manufacturing, and trading industries).
Idiopathic and Posttrauma Nightmares in a Clinical Sample of Children and Adolescents: Characteristics and Related Pathology

Nightmares occur commonly during childhood and adolescence as a part of normal childhood development and in response to a traumatic event. Although nightmares are known to be associated with psychological distress, few studies have examined potential differences between idiopathic nightmare sufferers and those whose nightmares began after exposure to a traumatic event (posttrauma). The present study examined such differences in 47 trauma-exposed children and adolescents attending an outpatient treatment facility. It was hypothesized that individuals with posttrauma nightmares would have increased posttraumatic stress disorder symptoms, anxiety, depression, and decreased sleep quality versus those with idiopathic nightmares or no nightmares. Results found that, in general, nightmares are associated with increased distress and impairment, and those with posttrauma nightmares fared worse on several measures of distress than those with idiopathic nightmares or no nightmares. Implications of the current study and suggestions for future research are discussed.
Tests for multiple forecast encompassing

In the evaluation of economic forecasts, it is frequently the case that comparisons are made between a number of competing predictors. A natural question to ask in such contexts is whether one forecast encompasses its competitors, in the sense that they contain no useful information not present in the superior forecast. We develop tests for this notion of multiple forecast encompassing which are robust to properties expected in the forecast errors, and apply the tests to forecasts of UK growth and inflation. Copyright © 2000 John Wiley & Sons, Ltd.
Responsible or redundant? Engaging the workforce through corporate social responsibility

Increasing attempts are being made to determine whether corporate social responsibility leads to commercial benefits. Research to date has demonstrated that corporate social responsibility is associated with attracting job-seekers and enhancing the engagement of employees. However, much of this research focuses on the impact of corporate social responsibility on employee outcomes independent of the impact of traditional human resource practices (e.g. training, rewards). Using a variation of an existing employee opinion survey, and applying Carroll’s (1979) model of corporate social responsibility, this paper assesses the relationship between employee engagement, traditional human resource practices, and corporate social responsibility. Data collected from 3147 employees showed a significant positive correlation between corporate social responsibility and employee engagement. However, corporate social responsibility explained little additional variance in engagement beyond that explained by traditional human resource practices. This paper concludes that allocating attention and resources to corporate social responsibility may not be as advantageous as investing in the improvement of core human resource practices, when the goal is to improve employee engagement. Future research needs to examine why corporate social responsibility explains little additional variance in employee engagement, specifically examining the manner in which employees perceive corporate social responsibility and the extent to which corporate social responsibility encompasses traditional human resource practices.
Similar Ends, Differing Means: Contractualism and Civil Service Reform in Denmark and New Zealand

State sector reform was an integral component of the radical economic and social policy changes enacted by New Zealand governments between 1984 and 1991. This reform replaced the traditional tenured public service with a contractual regime. Through a comparison with Denmark, it is shown that New Zealand's reforms were not unique. Similar reforms were enacted in Denmark. But contrary to what occurred in New Zealand, the Danish reforms had already begun in the 1960s, and have since been gradually expanded. The parallel contractual regimes introduced in the two countries are accounted for by an increasing demand among politicians to secure a civil service that is responsive to political executive demands. However, because of institutional differences and diverging regulatory regimes, the strategic approaches in the two countries have been different. Whereas the New Zealand approach was dominated by an appeal to a coherent and sophisticated body of theoretical knowledge, combined with strict formalization, the Danish strategy has been based on political bargaining with the civil service unions. In both cases the reforms rest on critical assumptions regarding their positive and negative implications.
PrPSc formation and clearance as determinants of prion tropism

Prion strains are characterized by strain-specific differences in neuropathology but can also differ in incubation period, clinical disease, host-range and tissue tropism. The hyper (HY) and drowsy (DY) strains of hamster-adapted transmissible mink encephalopathy (TME) differ in tissue tropism and susceptibility to infection by extraneural routes of infection. Notably, DY TME is not detected in the secondary lymphoreticular system (LRS) tissues of infected hosts regardless of the route of inoculation. We found that similar to the lymphotropic strain HY TME, DY TME crosses mucosal epithelia, enters draining lymphatic vessels in underlying laminae propriae, and is transported to LRS tissues. Since DY TME causes disease once it enters the peripheral nervous system, the restriction in DY TME pathogenesis is due to its inability to establish infection in LRS tissues, not a failure of transport. To determine if LRS tissues can support DY TME formation, we performed protein misfolding cyclic amplification using DY PrPSc as the seed and spleen homogenate as the source of PrPC. We found that the spleen environment can support DY PrPSc formation, although at lower rates compared to lymphotropic strains, suggesting that the failure of DY TME to establish infection in the spleen is not due to the absence of a strain-specific conversion cofactor. Finally, we provide evidence that DY PrPSc is more susceptible to degradation when compared to PrPSc from other lymphotrophic strains. We hypothesize that the relative rates of PrPSc formation and clearance can influence prion tropism.
Reconceptualizing the Firm in a World of Outsourcing and Offshoring: The Organizational and Geographical Relocation of High-Value Company Functions

In the largest sense, global strategy amounts to (1) the optimal disaggregation or slicing of the firm's value chain into as many constituent pieces as organizationally and economically feasible, followed by (2) decisions as how each slice should be allocated geographically (‘offshoring’) and organizationally (‘outsourcing’). Offshoring and outsourcing are treated as strategies that need to be simultaneously analysed, where just ‘core’ segments of the value chain are retained in-house, while others are optimally dispersed geographically, as well as dispersed over allies and contractors. This amounts to a reconsideration of the nature of the firm that captures the dynamic changes in global configuration and a reconsideration of what constitutes ‘core’ activities that need to be retained internally. The article proposes a new research agenda that searches for each firm's optimal degree of disaggregation and global dispersion given that further scattering of value chain activities entail benefits as well as increased complexity and costs.
The Impact of Strategic Entrepreneurship inside the Organization: Examining Job Stress and Employee Retention

How do managers and staff react to strategic entrepreneurship? How can we minimize resulting job stress and maximize employee retention? We surveyed 1,975 managers and staff in 110 departments of a diversified healthcare organization on department–level entrepreneurial orientation (EO) (e.g., risk taking, proactiveness, and innovativeness), degree of role ambiguity in their job, and their strength of intention to quit. After validating manager and staff reports of EO, we estimated structural equation models for managers and staff. Our results demonstrate that strategic entrepreneurship can impact management and staff differently and thus requires a correspondingly customized design philosophy.
Cisplatin-Induced Nephrotoxicity and HIV Associated Nephropathy: Mimickers of Myeloma-Like Cast Nephropathy

Myeloma cast nephropathy is an obstructing disorder of renal tubules, caused by precipitation of Bence Jones proteins. Myeloma-like cast nephropathy (MLCN) has been reported in the literature to occur in various primary renal and nonrenal diseases. We present a series of three rare cases of cast nephropathy, two of which are HIV patients, and the third patient is receiving cisplatin-based chemotherapy. However, in all three patients plasma cell dyscrasia has been ruled out. A 30-year-old male was admitted to the hospital with facial cellulitis. The second patient is a 31-year-old male who presented with Pneumocystis jiroveci pneumonia. The third patient was treated with cisplatin-based chemotherapy for carcinoma. First two cases revealed foci of diffuse tubular dilatation containing hyaline casts and interstitial inflammatory infiltrate, in addition to globally sclerotic glomeruli with ultrastructural foot process fusion and mesangium expansion. The third case showed acute tubular injury and cast formation of irregular casts composed of amorphous or granular material of low density admixed with scattered high electron-dense globules. Myeloma-like cast nephropathy and true myeloma cast nephropathy pose similar destructive effects on renal parenchyma. This new pattern of HIV-related nephropathy should be considered in HIV patients with MLCN, once monoclonal gammopathy is ruled out.
Eight criteria for practice-based research in the creative and cultural industries

This article addresses two core problems in practice-based research: the identification of fundamental conditions and, therefore, the identification of actual examples. It is critical of the methods in many earlier case studies involving circular argumentation. The article assumes that research in the creative and cultural industries is both situated in the largerfield of academic research and that it is a cumulative process. From this it develops a criterion-based approach to the necessary conditions.for such research, thereby enabling the identification of actual examples. This approach solves the circularity problem of earlier case studies. The article concludes that there are four generic and four discipline-specific criteria for academic research in the field. From these criteria other consequences follow for the content of practice-based research. These eight criteria are currently being used by the authors to identify and study cases of practice-based
Too Far to Go? Does Distance Determine Study Choices?

A number of studies have long shown that the probability of studying at university is influenced by the distance to the next university. This study shows for the first time that distance to university also influences the choice of subject/faculty and institution. Moreover, these findings are important because the distance effect in terms of these decisions is associated with significantly less risk of endogeneity than the effect in the analysis of the willingness and ambition to attend university. The results also show that distance does not influence study choices among students from the highest socioeconomic group, a finding that further indicates that distance to university is an expression of differences in the cost of a university education.
Welfare Changes and Sectoral Adjustments of Asia-Pacific Countries under Alternative Sequencings of Free Trade Agreements *

In this paper, we compare welfare effects and the extent of sectoral adjustments of the member countries under alternative free trade agreement (FTA) sequencings in the Asia-Pacific region using a dynamic computable general equilibrium (CGE) model. If a Trans-Pacific Partnership (TPP) agreement under one sequencing and an East Asian FTA (EAFTA) under another sequencing will enter into force at the same time, followed by more enlarged FTAs, then a larger number of countries are expected to realize greater welfare gains under the Asia-track sequencing. However, given the uncertainty about the establishment of an Asia-wide FTA in the near future, the TPP-track sequencing appears to be an attractive option for most countries in the Asia-Pacific region. With respect to sectoral adjustments, there seem to be no significant differences among the alternative sequencings considered in this study.
Niche and Direct Marketing in the Rural-Urban Fringe: A Study of the Agricultural Economy in the Lower-Mainland and Fraser Valley

Farmers in the rural-urban fringe (RUF) face unique challenges. Spillovers from the urban region and competition for land increase the costs of farming relative to farming farther removed. Yet, there is greater potential for off-farm employment and niche marketing of farm products, providing more income options to RUF farmers. In this research, we employ a survey of direct- and niche-marketing farmers located in the RUF of Vancouver, Canada to examine how the rural-urban interface affects farms, particularly their long-term survivability and sustainability. From a list of 102 direct marketing and organic farmers, we managed to elicit twenty-nine completed surveys. Annual gross farm receipts averaged almost $500,000, similar to the census average for all farms in the region. Incomes varied significantly among respondents and farmers produced a wide range of products, and yet exhibiting a willingness to invest in their farms. Respondents had been farming for an average over twenty years and are highly educated. Compared with farmers near Victoria, on Vancouver Island, producers who use direct marketing or organic methods in the Vancouver RUF have higher gross farm incomes, rely less on off-farm income and are much more likely to carry farm debt. Direct marketing also contributes to total farm sales, with only 19.5% of product value marketed at the farm-gate, at farmers’ markets or through delivery programs, compared to 57.3% of farms near Victoria. Wholesalers, distributors and processors play a larger role on the mainland, likely because the amount of farm product available makes operation of such facilities economically feasible.
Testing the One-Way Effect in the Presence of Trend Breaks

This paper provides an approach to testing the measures of the one-way effect for cointegrated vector time-series in the presence of trend breaks. We propose Wald testing the measures and their computational algorithm, an extension of previous work by Hosoya and Yao and Hosoya, to the case where trend breaks are explicitly taken into account in the cointegration relationship. On the basis of the proposed inferential method and the derived evidence, we present a causal structure characterization of money supply and income as well as interest rates for the last 44 years of the Japanese economy, and contrast it with the results of Yao and Hosoya.
Effect of cataract surgery with intraocular lens implantation on inflammation in chronic uveitis: a longitudinal laser flare photometry study.

BACKGROUND The precise effect of cataract surgery with implantation of an intraocular lens (IOL) on the course of uveitis is not well known. Laser flare photometry allows quantitative assessment of intraocular inflammation. The aim of this study was to determine the effect of cataract surgery with IOL implantation on the disease course and level of inflammation in chronic uveitis, using laser flare photometry monitoring. METHODS The charts of all patients who underwent surgery for secondary uveitic cataract between 1990 and 1994 (24/558 [4.3%]) were reviewed. Only eyes that had received standardized perioperative steroid treatment and had systematic laser flare photometry follow-up were included. Cataracts due to Fuchs' heterochromic cyclitis were excluded. Visual acuity, flare values and recurrence of flare episodes were compared before and after cataract surgery, and postoperative data were compared between eyes that received heparin-coated IOLs and those that received uncoated IOLs. RESULTS Nineteen eyes of 16 patients met the inclusion criteria. The mean length of the pre- and- postoperative follow-up periods was 779 and 444 days respectively. The mean visual acuity increased from 0.2 (standard error of the mean [SEM] 0.2) preoperatively to 0.8 (SEM 0.3) postoperatively (p < or = 0.001). The mean flare value decreased from 58.6 (SEM 18.6) photons/ms during preoperative follow-up to 29.7 (SEM 7.8) photons/ms during postoperative follow-up (p < or = 0.006). The mean number of recurrences per 6 months decreased from 0.27 (SEM 0.03) preoperatively to 0.12 (SEM 0.01) postoperatively (p < or = 0.05). The difference in the postoperative recurrence rate between the eyes that received coated IOLs (0.0) and those that received uncoated IOLs (0.18 [SEM 0.02]) approached statistical significance (p < or = 0.054). INTERPRETATION Quantitative assessment of inflammation by laser flare photometry in patients undergoing surgery for uveitic cataract showed that there was significantly less inflammation and fewer recurrences postoperatively and that recurrences were less severe.
Information Asymmetry and Financing Decisions

This study conducts tests of the pecking order theory using an international sample with more than 6000 firms over the period from 1995 to 2005. The high correlation between net equity issuances and the financing deficit discredits the static pecking order theory. Rather than analyzing the predictions of the theory, we test its core assumption that information asymmetry is an important determinant of capital structure decisions. Our empirical results support the dynamic pecking order theory and its two testable implications. First, the probability of issuing equity increases with less pronounced firm-level information asymmetry. Second, firms exploit windows of opportunity by making relatively larger equity issuances and build up cash reserves (slack) after declines in firm-level information asymmetry. Firms from common law countries use parts of their proceeds from an equity issuance to redeem debt and to rebalance their capital structure. These findings are consistent with a time-varying adverse selection explanation of firms' financing decisions.