Miracle-dz/UniFAR-FTUs huggingface dataset:
Alcohol Use Behaviors Among Pharmacy Students

Objective. To identify reasons for drinking, determine the patterns of alcohol abuse, and explore relationships between drinking motives and alcohol abuse patterns in pharmacy students. Methods. A cross-sectional anonymous, voluntary, self-administered paper survey instrument was administered to first-year (P1) through third-year (P3) pharmacy students as part of a professional seminar. Results. Survey instruments were completed by 349 pharmacy students (95.9% cooperation rate). Using the Alcohol Use Disorders Identification Test criteria, 23.2% of students reported hazardous or harmful use and 67.2% of students reported consuming alcohol at hazardous levels during the past year. Students who were male (37.0%), single (25.3%), and attended the main campus (26.2%) were more likely than their counterparts to report hazardous or harmful alcohol use. Pharmacy students reported social motives as the most common reason for drinking; however, coping and enhancement motives were more predictive of harmful or hazardous alcohol use. Conclusion. Approximately 1 in 4 pharmacy students (23%) reported hazardous or harmful alcohol use. Education about the dangers of alcohol abuse and intervention programs from colleges and schools of pharmacy are recommended to help address this issue.
Comment on "Pressure-induced structural and valence transition in AgO" by C. Hou, J. Botana, X. Zhang, X. Wang and M. Miao, Phys. Chem. Chem. Phys., 2016, 18, 15322.

The recent article by Hou et al. has focused on a theoretical study of mixed valence compound AgO in order to elucidate the nature of the electronic structure of this system as a function of external pressure. The authors claim that '…the effects of pressure on the Ag valence state are not investigated yet. ' This statement is incorrect in view of the theoretical study published in 2015 by Włodarska et al., which answers most of the questions posed by these authors, including the key one: '…does the Ag cation exhibit similar behaviour to the Au cation in M2Au2X6halides, experiencing mixed-valence to single-valence transition under pressure? If so, what is the mechanism? '.
Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research

Objective: To perform a systematic literature review of the long-term safety of methotrexate (MTX) monotherapy in rheumatoid arthritis (RA). Methods: A search was performed in Medline, Cochrane and EMBASE. Adults with RA who had received MTX monotherapy for more than 2 years were studied. Results: 88 published studies were included. Over 12 years of treatment, the termination rate of MTX due to toxicity was less than for sulfasalazine, gold, d-penicillamine and higher than for hydroxychloroquine (level of evidence 2a–2b). Long-term use of MTX does not appear to be a risk factor for serious infections, including herpes zoster (2b–4), and could provide a survival benefit by reducing cardiovascular mortality (2b). The prevalence of raised liver enzymes (more than twice the upper limit of normal) is close to 13% of patients; 3.7% of patients stopped MTX permanently owing to liver toxicity (2b). Data on the risk for liver fibrosis/cirrhosis are conflicting: a meta-analysis showed an incidence of fibrosis of 2.7% after 4 years of MTX (2a). However, two other studies on sequential liver biopsies did not show evidence for developing severe damage (2b). Insufficient data are available to fully assess the risk of lymphoma and malignancies, although there is no strong evidence of increased risk (2b–4). Conclusion: This systematic literature search on MTX monotherapy with relatively low-dose use during at least 2 years shows favourable long-term safety.
Quantile regression methods for reference growth charts

Estimation of reference growth curves for children's height and weight has traditionally relied on normal theory to construct families of quantile curves based on samples from the reference population. Age‐specific parametric transformation has been used to significantly broaden the applicability of these normal theory methods. Non‐parametric quantile regression methods offer a complementary strategy for estimating conditional quantile functions. We compare estimated reference curves for height using the penalized likelihood approach of Cole and Green (Statistics in Medicine 1992; 11:1305–1319) with quantile regression curves based on data used for modern Finnish reference charts. An advantage of the quantile regression approach is that it is relatively easy to incorporate prior growth and other covariates into the analysis of longitudinal growth data. Quantile specific autoregressive models for unequally spaced measurements are introduced and their application to diagnostic screening is illustrated. Copyright © 2005 John Wiley & Sons, Ltd.
BIOMECHANICAL ANALYSIS OF THE STANDING LONG JUMP

The purposes of the present study were to (1) investigate the effects of the arm movement and initial knee joint angle employed in standing long jump by the ground reaction force analysis and three-dimensional motion analysis; and (2) investigate how the jump performance of the female gender related to the body configuration. Thirty-four healthy adult females performed standing long jump on a force platform with full effort. Body segment and joint angles were analyzed by three-dimensional motion analysis system. Using kinetic and kinematic data, the trajectories on mass center of body, knee joint angle, magnitude of peak takeoff force, and impulse generation in preparing phase were calculated. Average standing long jump performances with free arm motion were +1.5 times above performance with restricted arm motion in both knee initial angles. The performances with knee 90° initial flexion were +1.2 times above performance with knee 45° initial flexion in free and restricted arm motions. Judging by trajectories of the center mass of body (COM), free arm motion improves jump distance by anterior displacement of the COM in starting position. The takeoff velocity with 90° knee initial angle was as much as 11% higher than in with 45° knee initial angle. However, the takeoff angles on the COM trajectory showed no significant differences between each other. It was found that starting jump from 90° bend knee relatively extended the time that the force is applied by the leg muscles. To compare the body configurations and the jumping scores, there were no significant correlations between jump scores and anthropometry data. The greater muscle mass or longer leg did not correlated well with the superior jumping performance.
Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy

The adenosine A1 G protein–coupled receptor (A1AR) is an important therapeutic target implicated in a wide range of cardiovascular and neuronal disorders. Although it is well established that the A1AR orthosteric site is located within the receptor’s transmembrane (TM) bundle, prior studies have implicated extracellular loop 2 (ECL2) as having a significant role in contributing to orthosteric ligand affinity and signaling for various G protein–coupled receptors (GPCRs). We thus performed extensive alanine scanning mutagenesis of A1AR-ECL2 to explore the role of this domain on A1AR orthosteric ligand pharmacology. Using quantitative analytical approaches and molecular modeling, we identified ECL2 residues that interact either directly or indirectly with orthosteric agonists and antagonists. Discrete mutations proximal to a conserved ECL2-TM3 disulfide bond selectively affected orthosteric ligand affinity, whereas a cluster of five residues near the TM4-ECL2 juncture influenced orthosteric agonist efficacy. A combination of ligand docking, molecular dynamics simulations, and mutagenesis results suggested that the orthosteric agonist 5′-N-ethylcarboxamidoadenosine binds transiently to an extracellular vestibule formed by ECL2 and the top of TM5 and TM7, prior to entry into the canonical TM bundle orthosteric site. Collectively, this study highlights a key role for ECL2 in A1AR orthosteric ligand binding and receptor activation.
Multisite Direct Determination of the Potential for Environmental Contamination of Urine Samples Used for Diagnosis of Sexually Transmitted Infections

Background The detection of a sexually transmitted infection (STI) agent in a urine specimen from a young child is regarded as an indicator of sexual contact. False positives may conceivably arise from the transfer of environmental contaminants in clinic toilet or bathroom facilities into urine specimens. Methods The potential for contamination of urine specimens with environmental STI nucleic acid was tested empirically in the male and female toilets or bathrooms at 10 Northern Territory (Australia) clinics, on 7 separate occasions at each. At each of the 140 experiments, environmental contamination with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis nucleic acid contamination was determined by swabbing 10 locations, and urine collection was simulated 5 times, using a (1) synthetic urine surrogate and (2) a standardized finger contamination procedure. Results The most contaminated toilets and bathrooms were in remote Indigenous communities. No contamination was found in the Northern Territory Government Sexual Assault Referral Centre clinics, and intermediate levels of contamination were found in sexual health clinics and in clinics in regional urban centres. The frequency of surrogate urine sample contamination was low but non-zero. For example, 4 of 558 of the urine surrogate specimens from remote clinics were STI positive. Conclusions This is by far the largest study addressing the potential environmental contamination of urine samples with STI agents. Positive STI tests arising from environmental contamination of urine specimens cannot be ruled out. The results emphasize that urine specimens from young children taken for STI testing should be obtained by trained staff in clean environments, and duplicate specimens should be obtained if possible.
Early maladaptive schemas and child and adult attachment: a 15-year longitudinal study.

OBJECTIVES To examine the relation between early maladaptive schemas (EMS), as defined in schema therapy, and both child and adult attachment. DESIGN A 15-year longitudinal design in which child attachment groups (secure, avoidant, ambivalent, and disorganized) were compared in early adulthood on their profile of scores across EMS domains. A similar strategy was used to examine EMS profiles as a function of adult attachment groups (secure, preoccupied, and fearful). METHODS Sixty participants, recruited from Montreal day-care centres, were assessed at 6 (Time 1) and 21 years of age (Time 2). Time 1 attachment was assessed using a separation-reunion procedure and Time 2 attachment, using the Experiences in Close Relationships questionnaire. EMS were evaluated with the Young Schema Questionnaire (Time 2). RESULTS There were more signs of EMS among young adults with either an insecure ambivalent child attachment, or an insecure preoccupied adult attachment style, compared to their secure peers. These differences were not specific to one domain of EMS; they were reported for various EMS. CONCLUSIONS The results suggest that specific elements of representational models are more likely to be related to the development of EMS: high anxiety over abandonment, negative self-view, and explicit manifestations of personal distress. Unmet childhood needs for secure attachment may lead to a large variety of EMS as defined in schema therapy.
Preserving Randomness for Adaptive Algorithms

Suppose $\mathsf{Est}$ is a randomized estimation algorithm that uses $n$ random bits and outputs values in $\mathbb{R}^d$. We show how to execute $\mathsf{Est}$ on $k$ adaptively chosen inputs using only $n + O(k \log(d + 1))$ random bits instead of the trivial $nk$ (at the cost of mild increases in the error and failure probability). Our algorithm combines a variant of the INW pseudorandom generator (STOC '94) with a new scheme for shifting and rounding the outputs of $\mathsf{Est}$. We prove that modifying the outputs of $\mathsf{Est}$ is necessary in this setting, and furthermore, our algorithm's randomness complexity is near-optimal in the case $d \leq O(1)$. As an application, we give a randomness-efficient version of the Goldreich-Levin algorithm; our algorithm finds all Fourier coefficients with absolute value at least $\theta$ of a function $F: \{0, 1\}^n \to \{-1, 1\}$ using $O(n \log n) \cdot \text{poly}(1/\theta)$ queries to $F$ and $O(n)$ random bits (independent of $\theta$), improving previous work by Bshouty et al. (JCSS '04).
Reading Engagement: Motivating Readers through Integrated Instruction.

Making students want to read is a top priority for many classroom and reading teachers. Reading Engagement helps educators understand the research on motivation and use it in their efforts to enhance children's literacy development. This book covers such diverse topics as children's motivations for reading, teacher perceptions, reading efficacy, and motivational development and focuses on classroom contexts for promoting reading engagement.
Formation of naked singularities: The violation of cosmic censorship.

We use a new numerical code to evolve collisionless gas spheroids in full general relativity. In all cases the spheroids collapse to singularities. When the spheroids are sufficiently compact, the singularities are hidden inside black holes. However, when the spheriods are sufficiently large, there are no apparent horizons. These results lend support to the hoop conjecture and appear to demonstrate that naked singularities can form in asymptotically flat spacetimes.
Deficits in attention, motor control, and perception: a brief review

The concept of DAMP (deficits in attention, motor control, and perception) has been in clinical use in Scandinavia for about 20 years. DAMP is diagnosed on the basis of concomitant attention deficit/hyperactivity disorder and developmental coordination disorder in children who do not have severe learning disability or cerebral palsy. In clinically severe form it affects about 1.5% of the general population of school age children; another few per cent are affected by more moderate variants. Boys are overrepresented; girls are currently probably underdiagnosed. There are many comorbid problems/overlapping conditions, including conduct disorder, depression/anxiety, and academic failure. There is a strong link with autism spectrum disorders in severe DAMP. Familial factors and pre- and perinatal risk factors account for much of the variance. Psychosocial risk factors appear to increase the risk of marked psychiatric abnormality in DAMP. Outcome in early adult age was psychosocially poor in one study in almost 60% of unmedicated cases. There are effective interventions available for many of the problems encountered in DAMP.
SkinScan©: A portable library for melanoma detection on handheld devices

We have developed a portable library for automated detection of melanoma termed SkinScan© that can be used on smartphones and other handheld devices. Compared to desktop computers, embedded processors have limited processing speed, memory, and power, but they have the advantage of portability and low cost. In this study we explored the feasibility of running a sophisticated application for automated skin cancer detection on an Apple iPhone 4. Our results demonstrate that the proposed library with the advanced image processing and analysis algorithms has excellent performance on handheld and desktop computers. Therefore, deployment of smartphones as screening devices for skin cancer and other skin diseases can have a significant impact on health care delivery in underserved and remote areas.
Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke

Objective: To analyze the frequency, clinical characteristics, and predictors of symptomatic intracerebral hemorrhage (ICH) after intraarterial (IA) thrombolysis with recombinant pro-urokinase (r-proUK) in acute ischemic stroke. Method: The authors conducted an exploratory analysis of symptomatic ICH from a randomized, controlled clinical trial of IA thrombolysis with r-proUK for patients with angiographically documented occlusion of the middle cerebral artery within 6 hours from stroke onset. Patients (n = 180) were randomized in a ratio of 2:1 to either 9 mg IA r-proUK over 120 minutes plus IV fixed-dose heparin or IV fixed-dose heparin alone. As opposed to intention to treat, this analysis was based on “treatment received” and includes 110 patients given r-proUK and 64 who did not receive any thrombolytic agent. The remaining six patients received out-of-protocol urokinase and were excluded from analysis. The authors analyzed centrally adjudicated ICH with associated neurologic deterioration (increase in NIH Stroke Scale [NIHSS] score of ≥4 points) within 36 hours of treatment initiation. Results: Symptomatic ICH occurred in 12 of 110 patients (10.9%) treated with r-proUK and in two of 64 (3.1%) receiving heparin alone. ICH symptoms in r-proUK–treated patients occurred at a mean of 10.2 ± 7.4 hours after the start of treatment. Mortality after symptomatic ICH was 83% (10/12 patients). Only blood glucose was significantly associated with symptomatic ICH in r-proUK–treated patients based on univariate analyses of 24 variables: patients with baseline glucose >200 mg/dL experienced a 36% risk of symptomatic ICH compared with 9% for those with ≤200 mg/dL (p = 0.022; relative risk, 4.2; 95% CI, 1.04 to 11.7). Conclusions: Symptomatic ICH after IA thrombolysis with r-proUK for acute ischemic stroke occurs early after treatment and has high mortality. The risk of symptomatic ICH may be increased in patients with a blood glucose >200 mg/dL at stroke onset.
Neither Jew Nor Gentile: Exploring Issues of Racial Diversity on Protestant College Campuses

INTRODUCTION 1. The Problem of the First-Person Point-of-View 2. Epistemic Position and the First Meditation 3. Imagining Mind and Body 4. The Idea of a Supreme Being 5. Truth and Imprecision in the Fourth Meditation 6. Another Proof of the Existence of God 7. Embodiment and Union 8. The Post-Meditations Meditator 9. Worries About Descartes' Method and its Implementation 10. Philosophical Inquiry and the Problem of Current Commitments
Radiofrequency ablation-assisted robotic laparoscopic partial nephrectomy without renal hilar vessel clamping versus laparoscopic partial nephrectomy: a comparison of perioperative outcomes.

OBJECTIVES Radiofrequency ablation (RFA)-assisted laparoscopic partial nephrectomy (LPN) may allow for improved hemostasis without need for renal hilar vessel clamping and elimination of warm ischemia to the kidney. We compare outcomes in patients undergoing radiofrequency ablation-assisted robotic clampless partial nephrectomy (RF-RCPN) and LPN. METHODS Thirty-six patients and 42 patients underwent LPN and RF-RCPN, respectively. In the RF-RCPN group, the Habib 4x RFA device was used to coagulate a margin of normal parenchyma around the renal mass to allow excision of the mass within a bloodless plane. Unlike in the LPN group, renal hilar vascular occlusion was not performed in the RF-RCPN group. RESULTS Tumors treated in the RF-RCPN group tended to be larger (2.8 vs. 2.0 cm) and more often endophytic (52.6% vs. 16.1%). Collecting system reconstruction occurred more often in the RF-RCPN group (78.6% vs. 30.6%). Operative duration was longer in the RF-RCPN group (373 vs. 250 minutes), but this included time for cystoscopy, ureteral stenting, and repositioning of the patient. Blood loss, transfusion rates, renal function, and complication rates did not differ between the two groups. No patients required renal hilar vessel clamping or nephrectomy to control bleeding in the RF-RCPN group. CONCLUSIONS The use of RFA-assistance during robotic partial nephrectomy allows excision of renal tumors without hilar vascular clamping, thus eliminating renal warm ischemia. Larger and more centrally located tumors were excised with RF-RCPN. No differences in blood loss, complication rate, postoperative bleeding, renal function, or recurrence rate were noted compared with LPN.
Lessons learned during implementation of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy in a regional transport program in Ontario.

BACKGROUND Therapeutic hypothermia (TH) is the first intervention to consistently show improved neurological outcomes in neonates with hypoxic ischemic encephalopathy (HIE). Since the recent introduction of TH for HIE in many centres, reviews of practices during the implementation of TH in Canada have not been published. OBJECTIVE To determine if eligible neonates are being offered TH and to identify any barriers to the effective implementation of TH. METHODS A retrospective review of neonates referred to a regional tertiary centre at a gestational age of 35 weeks or more with HIE was conducted. RESULTS Among 41 neonates referred, 29 (71%) were eligible for TH; among eligible patients, five were moribund and excluded, and TH was initiated in 16 (67%) of the remaining 24. Reasons for not cooling in eight eligible patients included a delay in referral (n=5, median age at referral was 14 h) and a failure to recognize the severity of HIE (n=3). Among cooled patients, median times were the following: 116 min for age at referral; 80 min for time from referral to transport team arrival; and 358 min for age at initiation of cooling. Seven (44%) patients had cooling initiated after 6 h of age. CONCLUSION A significant proportion of eligible patients were not offered TH, and in many cooled patients, initiation of cooling was delayed beyond the recommended 6 h. For eligible patients to benefit from TH, it is imperative that all birthing centres be made aware that TH is now widely available as an important treatment option, but also that TH is a time-sensitive therapy requiring rapid identification and referral. In the region studied, for eligible patients, referring hospitals should initiate passive cooling before arrival of the transport team. Referring hospitals should be prepared to provide early, yet safe initiation of passive cooling by having the appropriate equipment, and having staff trained in the use and monitoring of rectal temperatures.
A Mathematical Theory of Network Interference and Its Applications

In this paper, we introduce a mathematical framework for the characterization of network interference in wireless systems. We consider a network in which the interferers are scattered according to a spatial Poisson process and are operating asynchronously in a wireless environment subject to path loss, shadowing, and multipath fading. We start by determining the statistical distribution of the aggregate network interference. We then investigate four applications of the proposed model: 1) interference in cognitive radio networks; 2) interference in wireless packet networks; 3) spectrum of the aggregate radio-frequency emission of wireless networks; and 4) coexistence between ultrawideband and narrowband systems. Our framework accounts for all the essential physical parameters that affect network interference, such as the wireless propagation effects, the transmission technology, the spatial density of interferers, and the transmitted power of the interferers.