Miracle-dz/UniFAR-FTUs huggingface dataset:
The Mindfully Attached Therapist: Factors that Predict and Prevent the Development of Compassion Fatigue

OF THESIS THE MINDFULLY ATTACHED THERAPIST: FACTORS THAT PREDICT AND PREVENT THE DEVELOPMENT OF COMPASSION FATIGUE Characterized as a loss of empathy, compassion fatigue is experienced by many in the helping professions. Also known as secondary traumatic stress, compassion fatigue occurs when those in the helping professions experience trauma through interacting with the traumatic experiences of the people they are helping. Previous literature has found the development of compassion fatigue to be inevitable due to the amount of empathy those professionals must utilize on a daily basis. Mindfulness practices, such as Mindfulness Based Cognitive Therapy (MBCT) and Mindfulness Based Stress Reduction (MBSR) have been found to be a helpful learning tool for those in the helping professions to reduce their levels of stress. Using a convenience sample of 74 therapists, the present study utilized attachment as a framework for exploring factors of predicting and preventing compassion fatigue. Attachment styles in romantic relationships was predicted to be associated with the development of compassion fatigue, while mindfulness levels were predicted to be preventative in the development of compassion fatigue. Findings indicated that levels of compassion fatigue were higher for females, and that higher levels of mindfulness was associated with lower levels of compassion fatigue for both males and females. Implications for therapists, supervisors, and therapists-in-training are addressed.
Vogt‐Koyanagi‐Harada syndrome

Abstract. The case history is presented of a 40‐year‐old White woman with the Vogt‐Koyanagi‐Harada syndrome, who was successfully treated with a combination of low‐dose prednisolone and cyclosporine A. Cellular and humoral hypersensitivity to uveal and retinal antigens were demonstrated in the patient.
THE MASS–RADIUS(–ROTATION?) RELATION FOR LOW-MASS STARS

The fundamental properties of low-mass stars are not as well understood as those of their more massive counterparts. The best method for constraining these properties, especially masses and radii, is to study eclipsing binary systems, but only a small number of late-type (⩾M0) systems have been identified and well characterized to date. We present the discovery and characterization of six new M dwarf eclipsing binary systems. The 12 stars in these eclipsing systems have masses spanning 0.38–0.59 M☉ and orbital periods of 0.6–1.7 days, with typical uncertainties of ∼0.3% in mass and ∼0.5%–2.0% in radius. Combined with six known systems with high-precision measurements, our results reveal an intriguing trend in the low-mass regime. For stars with M= 0.35–0.80 M☉, components in short-period binary systems (P≲1 day; 12 stars) have radii which are inflated by up to 10% (μ = 4.8% ± 1.0%) with respect to evolutionary models for low-mass main-sequence stars, whereas components in longer-period systems (>1.5 days; 12 stars) tend to have smaller radii (μ = 1.7% ± 0.7%). This trend supports the hypothesis that short-period systems are inflated by the influence of the close companion, most likely because they are tidally locked into very high rotation speeds that enhance activity and inhibit convection. In summary, very close binary systems are not representative of typical M dwarfs, but our results for longer-period systems indicate that the evolutionary models are broadly valid in the M∼ 0.35–0.80 M☉ regime.
Bacterial profiling of White Plague Disease across corals and oceans indicates a conserved and distinct disease microbiome

Coral diseases are characterized by microbial community shifts in coral mucus and tissue, but causes and consequences of these changes are vaguely understood due to the complexity and dynamics of coral‐associated bacteria. We used 16S rRNA gene microarrays to assay differences in bacterial assemblages of healthy and diseased colonies displaying White Plague Disease (WPD) signs from two closely related Caribbean coral species, Orbicella faveolata and Orbicella franksi. Analysis of differentially abundant operational taxonomic units (OTUs) revealed strong differences between healthy and diseased specimens, but not between coral species. A subsequent comparison to data from two Indo‐Pacific coral species (Pavona duerdeni and Porites lutea) revealed distinct microbial community patterns associated with ocean basin, coral species and health state. Coral species were clearly separated by site, but also, the relatedness of the underlying bacterial community structures resembled the phylogenetic relationship of the coral hosts. In diseased samples, bacterial richness increased and putatively opportunistic bacteria were consistently more abundant highlighting the role of opportunistic conditions in structuring microbial community patterns during disease. Our comparative analysis shows that it is possible to derive conserved bacterial footprints of diseased coral holobionts that might help in identifying key bacterial species related to the underlying etiopathology. Furthermore, our data demonstrate that similar‐appearing disease phenotypes produce microbial community patterns that are consistent over coral species and oceans, irrespective of the putative underlying pathogen. Consequently, profiling coral diseases by microbial community structure over multiple coral species might allow the development of a comparative disease framework that can inform on cause and relatedness of coral diseases.
Tracking analysis of a generalized adaptive notch filter

The paper presents results of local performance analysis of a generalized adaptive notch filter (GANF). GANFs are used for identification/tracking of quasi-periodically varying dynamic systems and can be considered an extension, to the system case, of classical adaptive notch filters. The tracking properties of the algorithm are studied analytically using a direct averaging approach and an approximating linear filter technique. Even though restricted to a single-frequency case, the presented analysis provides valuable insights into the tracking mechanisms of GANF, including the associated speed/accuracy tradeoffs, the achievable performance bounds, and tracking limitations. In addition, it allows one to formulate some useful rules of thumb for choosing design parameters.
Imagining a better memory: Theoretical and clinical implications of the self-imagination effect in memory

Prior research suggests that aspects of self-knowledge are relatively intact in many memory-impaired patients with acquired brain injury. Therefore, cognitive s rategies that rely on preserved mechanisms of the self may be particularly effective i n this population. The three studies presented in this dissertation investigated the practical ut ility and mnemonic mechanisms of a novel cognitive strategy designed to capitalize on s elfreferential processing: self-imagination. Study 1 investigated the effect of self-imagining on cued recall in memory-impaired patients with acquired brain injury and healt hy controls. Sixteen patients and sixteen healthy controls intentionally encoded wor d pairs under four separate conditions: visual imagery, semantic elaboration, other person imagining, and self-imagining. The results revealed that self-imaginin g enhanced cued recall more than the other encoding conditions in patients and healthy controls. Study 2 was an initial investigation of the effect of self-imagining on free recal l. Twenty healthy adults intentionally encoded word pairs under four conditions: self-imagining, a se lfdescriptiveness task thought to rely on access to semantic information in self -k ow edge, an autobiographical memory task requiring retrieval of a self-relevant epi sodic memory, and a structural processing task. The results demonstrated that self-imagi ning improved free recall more than the other encoding conditions in healthy adults. Study 3 investigated the effect of self-imagining on free recall in memory-i mpa red patients with acquired brain injury and healthy controls. Fifteen patients and fifteen healt hy controls intentionally encoded personality trait adjectives under five conditions: a s elf-imagining task, a self-descriptiveness task, an episodic autobiographical memory tas k, a semantic
The Psychometric Properties of the Sexual Excitation/Sexual Inhibition Inventory for Women (SESII-W) Within a Dutch Population

According to the dual control model, sexual arousal is dependent on the disposition for both sexual excitation (SE) and sexual inhibition (SI; Bancroft, 1999). Individual variability in sexual inhibition and sexual excitation could partly explain individual differences in sexual arousability and the likelihood of experiencing sexual problems (Bancroft, Graham, Janssen, & Sanders, 2009). The Sexual Excitation/Sexual Inhibition Inventory for Women (SESII-W) is a questionnaire developed to measure the factors sexual excitation and sexual inhibition (Graham, Sanders, & Milhausen, 2006). This study describes the validation of the Dutch version of the SESII-W in a sample of 445 women. Using confirmatory factor analysis, we determined that the eight lower-order factor model achieved adequate fit to the data. A decrement in fit was noted when the two higher-order factors SE and SI were included in the model. The measure demonstrated good construct validity, internal consistency, and test-retest reliability. Furthermore, the scores of women with sexual problems differed from those without sexual problems, providing evidence for the discriminant validity of the SESII-W.
Dermoscopy of Superficial Basal Cell Carcinoma

© 2005 by the American Society for Dermatologic Surgery, Inc. • Published by BC Decker Inc ISSN: 1076–0512 • Dermatol Surg 2005;31:1710–1713. DERMOSCOPY (dermatoscopy, surface microscopy, epiluminescence microscopy) is a noninvasive technique that improves the diagnostic accuracy of many pigmented skin lesions (PSLs) compared with naked-eye examination.1 In past decades, much work has concentrated on improving diagnostic precision in malignant PSL. Subsequently, the dermoscopic pigment patterns of melanoma and pigmented basal cell carcinoma (BCC) have been studied extensively.1–9 However, dermoscopy may also prove useful in nonpigmented skin tumors, for which the clinical diagnosis is often uncertain and/or implicates a variety of differential diagnoses. In this situation, dermoscopic features, such as blood vessel morphology, may be of primary importance. Consequently, the vascular morphologies found in various skin lesions have recently been given more attention.10–13 Superficial BCC, a distinct type of BCC, is typically nonpigmented. Although dermoscopic criteria have been formulated to improve the diagnostic accuracy for pigmented BCC, the dermoscopic features of superficial BCC have yet to be formally examined.
Is the anti-correlation between the X-ray variability amplitude and black hole mass of AGNs intrinsic? (Research Note)

Aims. Both the black hole mass and the X-ray luminosity of active galactic nuclei (AGNs) have been found to be anti-correlated with the normalized excess variance (σ 2) of the X-ray light curves. We investigate which correlation with σ 2 is the intrinsic one. Methods. We divided a full sample of 33 AGNs (O’ Neill et al. 2005, MNRAS, 358, 1405) into two subsamples. The black hole masses of 17 objects in subsample 1 were determined by reverberation mapping or stellar velocity dispersion. The black hole masses of the remaining 16 objects were estimated from the relationship between broad-line region radius and optical luminosity (subsample 2). We then performed partial correlation analysis, ordinary least-squares regression, and K–S tests on the full sample and the subsamples, respectively. Results. We found that σ 2 seems to be intrinsically correlated with the black hole mass in the full sample. However, this seems to be caused by including subsample 2 in the analysis, which introduces an extra correlation between the black hole mass and the luminosity and strengthens any correlation with the black hole mass artificially. Therefore, the results from the full sample may be misleading. The results from the subsample 1 show that the correlation between σ 2 and the X-ray luminosity may be the intrinsic one and, therefore, the anti-correlation between σ 2 and the black hole mass is doubtful.
HPGCD Outperforms HPBCD as a Potential Treatment for Niemann‐Pick Disease Type C During Disease Modeling with iPS Cells

Niemann‐Pick disease type C (NPC) is a lysosomal storage disease characterized by abnormal accumulation of free cholesterol and glycolipids. Here, we established induced pluripotent stem cell (iPSC) lines from NPC patients. Hepatocyte‐like cells (HLCs) and neural progenitors derived from the iPSC lines accumulated cholesterol and displayed impaired autophagy and ATP production. A molecular signature related to lipid metabolism was also impaired in the NPC‐iPSC‐derived HLCs. These findings indicate that iPSC‐derived cells can phenocopy human NPC. We also newly found that 2‐hydroxypropyl‐γ‐cyclodextrin (HPGCD) could reduce the cholesterol accumulation and restore the functional and molecular abnormalities in the NPC patient‐derived cells, and do so more effectively than 2‐hydroxypropyl‐β‐cyclodextrin treatment. In addition, NPC model mice showed an improved liver status and prolonged survival with HPGCDs. Thus, iPSC lines derived from patient cells are powerful tools to study cellular models of NPC, and HPGCD is a potential new drug candidate for future treatment of this disease. Stem Cells 2015;33:1075–1088
In vitro evaluation of the antimicrobial activity of lichen metabolites as potential preservatives

Antimicrobial screening of several lichen species and subsequent isolation and structure elucidation of active compounds revealed that the hydrolysis products of certain lichen metabolites, i.e., depsides, were active against gram-negative bacteria and fungi as well as gram-positive bacteria. The active constituents isolated from Stereocaulon alpinum and Peltigera aphthosa were identified, respectively, as methyl beta-orsellinate and a mixture of methyl and ethyl orsellinates. MIC determinations indicated that activity of these compounds was superior to that of the commonly used preservative agents methyl and propyl p-hydroxybenzoates and was of the same order as that of chlorocresol.
IL13 activates autophagy to regulate secretion in airway epithelial cells

ABSTRACT Cytokine modulation of autophagy is increasingly recognized in disease pathogenesis, and current concepts suggest that type 1 cytokines activate autophagy, whereas type 2 cytokines are inhibitory. However, this paradigm derives primarily from studies of immune cells and is poorly characterized in tissue cells, including sentinel epithelial cells that regulate the immune response. In particular, the type 2 cytokine IL13 (interleukin 13) drives the formation of airway goblet cells that secrete excess mucus as a characteristic feature of airway disease, but whether this process is influenced by autophagy was undefined. Here we use a mouse model of airway disease in which IL33 (interleukin 33) stimulation leads to IL13-dependent formation of airway goblet cells as tracked by levels of mucin MUC5AC (mucin 5AC, oligomeric mucus/gel forming), and we show that these cells manifest a block in mucus secretion in autophagy gene Atg16l1-deficient mice compared to wild-type control mice. Similarly, primary-culture human tracheal epithelial cells treated with IL13 to stimulate mucus formation also exhibit a block in MUC5AC secretion in cells depleted of autophagy gene ATG5 (autophagy-related 5) or ATG14 (autophagy-related 14) compared to nondepleted control cells. Our findings indicate that autophagy is essential for airway mucus secretion in a type 2, IL13-dependent immune disease process and thereby provide a novel therapeutic strategy for attenuating airway obstruction in hypersecretory inflammatory diseases such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis lung disease. Taken together, these observations suggest that the regulation of autophagy by Th2 cytokines is cell-context dependent.
Reading Problems, Attentional Deficits, and Current Mental Health Status in Adjudicated Adolescent Males

This study examined the prevaience of reading probiems and seif-reported symptoms of attentionai deficits in a sample of adjudicated adoiescent maies (N = 101) aged 12 to 18 years who were residing in an aiternative sentencing residentiai program. Thirtyfour percent of the youth had reading probiems whiie oniy 9% of the boys had selfreported attentionai deficits. An additionai 10% of the youth reported experiencing both reading probiems and attentionai difficulties. Resuits indicated that maie offenders with attentionai deficits reported greater depression, reduced seif-concept, and a more external locus of control at intake than maie offenders with reading difficuities. Furthermore, maie youth offenders with reading and attentionai probiems reported more depression, iess positive self-concepts and a more external iocus of control than did youth with reading problems oniy, but did not differ significantiy from the group who only reported attentionai problems. Overail, these findings exempiify the need for both educational and psychological interventions for youVi entering the juveniie justice system. Psychoiogicai interventions for maie offenders who self-report attentionai difficulties may be particuiariy wananted.
On the Causes of Circulating Currents in PWM Drives With Open-End Winding AC Machines

Electric drives with open-end winding ac machines offer certain advantages over drives with star- or delta-connected machines. Such drives have been recently considered for some applications such as electric vehicles. Circulating currents have been experimentally observed in such open-end winding ac drives. These currents have the effect of increasing conduction losses in the stator winding resistance of the ac machine. Two major causes for these currents have been identified as device voltage drops in power semiconductor devices and dead time used for shoot-through current protection. These effects are analyzed, and a mathematical description for predicting their severity is provided. Experimental results are presented that support the theory. The theory developed should be useful for devising solutions for this problem such as the design of common-mode filters. Two methods of suppressing the circulating currents are also outlined, and their experimental results are presented.
Preemptive craniectomy with craniotomy: what role in the management of severe traumatic brain injury?

BACKGROUND Patients with severe traumatic brain injury (TBI) require aggressive management to prevent secondary brain injury. "Preemptive" craniectomy (CE)--craniectomy performed as a primary procedure in conjunction with craniotomy--has been used as prophylaxis for secondary injury, but the indications and outcomes of craniectomy used for this purpose are not well defined. METHODS To evaluate the role of CE in the management of TBI, we retrospectively reviewed 62 consecutive patients who underwent CE in a 78-month period at our level I trauma center. A cohort of patients who underwent craniotomy only (CO) during this period was compared with the CE group for TBI patterns, indications for operation, and outcomes. Multivariable logistic regression and matched propensity score analysis were used to test the association between CE and survival. The rate of CE was determined by individual neurosurgeons. RESULTS Of 197 patients with brain injuries who underwent craniotomy, 62 (31.5%) had CE and 135 (68.5%) had CO. Mean age for CE versus CO was 41 years versus 51 years (p < 0.01). Mean admission Glasgow Coma Score was lower in CE versus CO (7.6 vs. 11.8, p < 0.001); Injury Severity Score was higher (30.2 vs. 26.3, p < 0.01). The indication for operation for CE compared with CO was subdural hematoma in 41 (66.1%) versus 87 (64.4%, p = 0.82), epidural hematoma in 2 (3.2%) versus 26 (19.3%, p < 0.01), and cerebral contusion or hematoma in 15 (24.2%) versus 8 (5.9%, p < 0.001). Postoperative intracranial pressure was monitored in 48 (77.4%) CE and 44 (32.6%) CO patients (p < 0.001). Intracranial pressure <20 was maintained in 26 (54.2%) after CE and in 31 (70.5%) after CO (p = 0.12). In the CE group, 26 (42%) died compared with 31 (26%, p < 0.01) in the CO group. When adjusted for severity of injury, however, there was no significant difference in mortality between the two groups (p = 0.134). The CE rate obtained by a neurosurgeon varied from 8.6% to 75.0% (p < 0.001). CONCLUSION CE was used in patients with more severe injuries, and particularly in those with more severe head injuries. When adjusted for injury severity, CE was not associated with worsened survival, and therefore may reasonably be included in the armamentarium of neurotrauma care. Use of CE by our neurosurgeons, however, varied significantly. These findings underscore the need for practice guidelines based on randomized trials to fully evaluate the role of CE in the management of TBI.
Capacity and delay analysis for social-proximity urban vehicular networks

In this paper, the asymptotic capacity and delay performance of social-proximity urban vehicular networks with inhomogeneous vehicle density are analyzed. Specifically, we investigate the case of N vehicles in a grid-like street layout while the number of road segments increases linearly with the population of vehicles. Each vehicle moves in a localized mobility region centered at a fixed social spot and communicates to a destination vehicle in the same mobility region via a unicast flow. With a variant of the two-hop relay scheme applied, we show that social-proximity urban networks are scalable: a constant average per-vehicle throughput can be achieved with high probability. Furthermore, although the throughput and delay of a unicast flow may degrade in a high density area, almost constant per-vehicle throughput Ω(1/log (N)) and almost constant delay O(log2 (N)) (except for the polylogarithmic factor) are still achievable with high probability. By identifying the key impact factors of performance mathematically, our results should provide insight on the design and deployment of future vehicular networks.
Towards Automated Development of Multi-Agent Systems Using RADE

To facilitate the development of multi-agent systems and improve the reusability, robustness and feasibility of these systems, we proposed a role-based agent development framework (RADE). In this paper, we present more details on the design of agents and motivations within such framework. We introduce a practical approach to modeling agent’s motivation and specifying agent’s goals, where a role-mapping mechanism is developed based on this design. We also introduce the RTAEMS language based on the extension of TAEMS to model the plan tree for each goal. This representation is used to support the development of general planning/scheduling and collaboration/cooperation mechanisms.
Predicting group performance using group indices: A new proposal

This research is focused on the influence of different psychological variables over group performance. Specifically, personality measures, the Skew-symmetry index [1], and generalized/dyadic measurements of reciprocity of the Social Relations Model [2] were analyzed. The objective was to examine whether personality measures, values or generalize/dyadic (or both) reciprocity measurements in interpersonal perceptions could explain group performance (following a round robin paradigm).