Miracle-dz/UniFAR-FTUs huggingface dataset:
Collision Warning Timing, Driver Distraction, and Driver Response to Imminent Rear-End Collisions in a High-Fidelity Driving Simulator

Rear-end collisions account for almost 30% of automotive crashes. Rear-end collision avoidance systems (RECASs) may offer a promising approach to help drivers avoid these crashes. Two experiments performed using a high-fidelity motion-based driving simulator examined driver responses to evaluate the efficacy of a RECAS. The first experiment showed that early warnings helped distracted drivers react more quickly---and thereby avoid more collisions---than did late warnings or no warnings. Compared with the no-warning condition, an early RECAS warning reduced the number of collisions by 80.7%. Assuming collision severity is proportional to kinetic energy, the early warning reduced collision severity by 96.5%. In contrast, the late warning reduced collisions by 50.0 % and the corresponding severity by 87.5%. The second experiment showed that RECAS benefits even undistracted drivers. Analysis of the braking process showed that warnings provide a potential safety benefit by reducing the time required for drivers to release the accelerator. Warnings do not, however, speed application of the brake, increase maximum deceleration, or affect mean deceleration. These results provide the basis for a computational model of driver performance that was used to extrapolate the findings and identify the most promising parameter settings. Potential applications of these results include methods for evaluating collision warning systems, algorithm design guidance, and driver performance model input.
Modeling of seismic guided waves at the Dead Sea Transform

[1] On several recordings of linear seismometer arrays crossing the Arava Fault (AF) in the Middle East, we see prominent wave trains emerging from in-fault explosions which we interpret as waves being guided by a fault zone related low-velocity layer. The AF is located in the Arava Valley and is considered the principal active fault of the mainly N-S striking Dead Sea Transform System in this section. Observations of these wave trains are confined to certain segments of the receiver lines and occur only for particular shot locations. They exhibit large amplitudes and are almost monochromatic. We model them by a two-dimensional (2-D) analytical solution for the scalar wave field in models with a vertical waveguide embedded in two quarter spaces. A hybrid search scheme combining genetic algorithm and a local random search is employed to explore the multimodal parameter space. Resolution is investigated by synthetic tests. The observations are adequately fit by models with a narrow, only 3–12 m wide waveguide with S wave velocity reduced by 10–60% of the surrounding rock. We relate this vertical low-velocity layer with the damage zone of the AF since the location of receivers observing and of shots generating the guided waves, respectively, match with the surface trace of the fault. The thickness of the damage zone of the AF, at least at shallow depths, seems to be much smaller than in other major fault zones. This could be due to less total slip on this fault.
UNESCO Global Geoparks: a strategy towards global understanding and sustainability

European Union through the Euro- pean Regional Development Fund, based on COMPETE 2020 (Pro- grama Operacional da Competitividade e Internacionalizacao), project ICT (UID/GEO/04683/2013 and UID/Multi00073/2013) with reference POCI-01-0145-FEDER-007690 and national funds provided by Fundacao para a Ciencia e Tecnologia
Behavioral Correlates of Caffeine Consumption by Children

In children, caffeine intake as a function of body weight is highest below age five 5 years. 1,2 Based on data obtained by the Marketing Research Corporation of America, the 90th percentile levels of caffeine intake among consumers (in mg/kg) are estimated to be 0.7 for infants, 2.1 for children 1 to 5 years of age, and 1.4 for children 6 to 1’7 years. ’ Children tended to get most of their caffeine from coffee
Neutrophil Extracellular Traps Microcrystals Induce Formation of Calcium Pyrophosphate Dihydrate Pseudogout-Associated Inflammatory

Pseudogout is an autoinﬂammatory condition triggered by calcium pyrophosphate dehydrate (CPPD) crystal deposition in the joints. The innate immune system is irritated by and responds to the presence of the crystals with an inﬂammatory response. The synovial ﬂuid contains activated inﬂammatory macrophages and neutrophil granulocytes. Several details of crystal-induced macrophage activation were recently uncovered, but very little is known about interactions of CPPD crystals with neutrophils. In this study, we show that human neutrophils engulf CPPD crystals and form large amounts of neutrophil extracellular traps (NETs) in vitro. Released extracellular DNA binds myeloperoxidase and citrullinated histone H4. CPPD crystal–stimulated neutrophils and their nuclear DNA undergo morphological changes characteristic for NET formation. The ERK/MEK signaling pathway, heat shock protein 90, PI3K, and an intact cytoskeleton are required for CPPD-induced NET formation. Blocking crystal-activated respiratory burst has, however, no effect on NETs. Human neutrophils release IL-1 b and IL-8 in response to CPPD crystals, and blocking CXCR2, the main IL-8R, diminishes NET formation. Proinﬂammatory cytokines, TNF- a , GM-CSF, and IL-1 b , increase NET release by the crystals. Enhanced bacterial killing by CPPD-induced NETs demonstrates their ability to cause cellular damage. Our work documents and provides details about extracellular trap release in human neutrophils activated by CPPD microcrystals. We suggest that crystal-triggered NET formation can be a novel contributor to inﬂammatory conditions observed in CPPD crystal–driven synovitis. The Journal of Immunology , 2013, 190: 000–000.
Central Circadian Control of Female Reproductive Function

Over the past two decades, it has become clear just how much of our physiology is under the control of the suprachiasmatic nucleus (SCN) and the cell-intrinsic molecular clock that ticks with a periodicity of approximately 24 h. The SCN prepares our digestive system for meals, our adrenal axis for the stress of waking up in the morning, and the genes expressed in our muscles when we prepare to exercise. Long before molecular studies of genes such as Clock, Bmal1, and the Per homologs were possible, it was obvious that female reproductive function was under strict circadian control at every level of the hypothalamic-pituitary-gonadal axis, and in the establishment and successful maintenance of pregnancy. This review highlights our current understanding of the role that the SCN plays in regulating female reproductive physiology, with a special emphasis on the advances made possible through the use of circadian mutant mice.
Generating Satisfiable Problem Instances

A major difficulty in evaluating incomplete local search style algorithms for constraint satisfaction problems is the need for a source of hard problem instances that are guaranteed to be satisfiable. A standard approach to evaluate incomplete search methods has been to use a general problem generator and a complete search method to filter out the unsatisfiable instances. Unfortunately, this approach cannot be used to create problem instances that are beyond the reach of complete search methods. So far, it has proven to be surprisingly difficult to develop a direct generator for satisfiable instances only. In this paper, we propose a generator that only outputs satisfiable problem instances. We also show how one can finely control the hardness of the satisfiable instances by establishing a connection between problem hardness and a new kind of phase transition phenomenon in the space of problem instances. Finally, we use our problem distribution to show the easy-hard-easy pattern in search complexity for local search procedures, analogous to the previously reported pattern for complete search methods. In Proceedings of AAAI-2000, Austin, Texas, USA
Characterization of Cytomegalovirus Disease in Solid Organ Transplant Recipients by Markers of Inflammation in Plasma

Background While several studies have examined the general inflammatory responses in relation to cytomegalovirus infection, the identification of the various inflammatory mediators as well as their relative importance is far from clear. Patients and Methods Solid organ recipients enrolled in an international multicenter trial of cytomegalovirus disease treatment (the VICTOR study) were analyzed (n = 289) (ClinicalTrials.gov NCT00431353). Plasma markers of inflammation and endothelial cell activation were assessed at baseline by enzyme immunoassays. Results The major findings were: (i) Plasma levels of the CXC-chemokine interferon-inducible protein-10 (P<0.001) and C-reactive protein (P = 0.046) were independently associated with the presence of cytomegalovirus DNAemia above lower level of quantification. (ii) High levels of CC-chemokine ligand 21 (P = 0.027) and pentraxin 3 (P = 0.033) were independently associated with tissue invasive cytomegalovirus disease as opposed to cytomegalovirus syndrome. Conclusion Our findings illustrate the complex interaction between cytomegalovirus and the immune system, involving a wide range of inflammatory mediators that could be associated to disease manifestations in cytomegalovirus related disease.
Learning More Effective Dialogue Strategies Using Limited Dialogue Move Features

We explore the use of restricted dialogue contexts in reinforcement learning (RL) of effective dialogue strategies for information seeking spoken dialogue systems (e.g. COMMUNICATOR (Walker et al., 2001)). The contexts we use are richer than previous research in this area, e.g. (Levin and Pieraccini, 1997; Scheffler and Young, 2001; Singh et al., 2002; Pietquin, 2004), which use only slot-based information, but are much less complex than the full dialogue "Information States" explored in (Henderson et al., 2005), for which tractabe learning is an issue. We explore how incrementally adding richer features allows learning of more effective dialogue strategies. We use 2 user simulations learned from COMMUNICATOR data (Walker et al., 2001; Georgila et al., 2005b) to explore the effects of different features on learned dialogue strategies. Our results show that adding the dialogue moves of the last system and user turns increases the average reward of the automatically learned strategies by 65.9% over the original (hand-coded) COMMUNICATOR systems, and by 7.8% over a baseline RL policy that uses only slot-status features. We show that the learned strategies exhibit an emergent "focus switching" strategy and effective use of the 'give help' action.
Geometric bistellar flips. The setting, the context and a construction

We give a self-contained introduction to the theory of secondary polytopes and geometric bistellar flips in triangulations of polytopes and point sets, as well as a review of some of the known results and connections to algebraic geometry, topological combinatorics, and other areas. As a new result, we announce the construction of a point set in general position with a disconnected space of triangulations. This shows, for the first time, that the poset of strict polyhedral subdivisions of a point set is not always connected.
Lack of the COMPASS Component Ccl1 Reduces H3K4 Trimethylation Levels and Affects Transcription of Secondary Metabolite Genes in Two Plant–Pathogenic Fusarium Species

In the two fungal pathogens Fusarium fujikuroi and Fusarium graminearum, secondary metabolites (SMs) are fitness and virulence factors and there is compelling evidence that the coordination of SM gene expression is under epigenetic control. Here, we characterized Ccl1, a subunit of the COMPASS complex responsible for methylating lysine 4 of histone H3 (H3K4me). We show that Ccl1 is not essential for viability but a regulator of genome-wide trimethylation of H3K4 (H3K4me3). Although, recent work in Fusarium and Aspergillus spp. detected only sporadic H3K4 methylation at the majority of the SM gene clusters, we show here that SM profiles in CCL1 deletion mutants are strongly deviating from the wild type. Cross-complementation experiments indicate high functional conservation of Ccl1 as phenotypes of the respective △ccl1 were rescued in both fungi. Strikingly, biosynthesis of the species-specific virulence factors gibberellic acid and deoxynivalenol produced by F. fujikuroi and F. graminearum, respectively, was reduced in axenic cultures but virulence was not attenuated in these mutants, a phenotype which goes in line with restored virulence factor production levels in planta. This suggests that yet unknown plant-derived signals are able to compensate for Ccl1 function during pathogenesis.
Hormonal therapy with megestrol in inoperable hepatocellular carcinoma characterized by variant oestrogen receptors

Variant liver oestrogen receptor transcripts in hepatocellular carcinoma are associated with aggressive clinical course and unresponsiveness to tamoxifen. To evaluate the impact on survival and on tumour growth of megestrol (progestin drug acting at post-receptorial level) we enrolled 45 patients with HCC characterized by variant liver oestrogen receptors in a prospective, randomized study with megestrol vs. placebo. Presence of variant oestrogen receptors was determined by RT/PCR. 24 patients were randomized to no treatment and 21 to therapy with megestrol 160 mg day–1. Results were analysed by Kaplan-Meier and Cox methods. Survival of hepatocellular carcinoma characterized by variant oestrogen receptors was extremely poor (median survival 7 months); megestrol significantly improved survival (18 months) (P = 0.0090). Tumour growth at one year was significantly slowed down in megestrol-treated patients (P = 0.0212). Bilirubin levels, presence of portal thrombosis, HBV aetiology and treatment were identified at univariate analysis as factors significantly associated with survival; at multivariate analysis, only megestrol therapy (P = 0.0003), presence of HBV infection (P = 0.0009) and presence of portal vein thrombosis (P = 0.0051) were factors independently related with survival. (1) Megestrol slows down the aggressive tumour growth of patients with hepatocellular carcinoma characterized by variant estrogen receptors and (2) is also able to favourably influence the course of disease, more than doubling median survival. © 2001 Cancer Research Campaign
Interaction between host genotype and environmental conditions affects bacterial density in Wolbachia symbiosis

Regulation of microbial population density is a necessity in stable symbiotic interactions. In Wolbachia symbiosis, both bacterial and host genotypes are involved in density regulation, but environmental factors may also affect bacterial population density. Here, we studied the interaction between three strains of Wolbachia in two divergent homozygous lines of the wasp Leptopilina heterotoma at two different temperatures. Wolbachia density varied between the two host genotypes at only one temperature. Moreover, at this temperature, reciprocal-cross F1 insects displayed identical Wolbachia densities, which were intermediate between the densities in the two parental lines. While these findings confirm that the host genotype plays an important role in Wolbachia density, they also highlight its interaction with environmental conditions, making possible the evolution of local adaptations for the regulation of Wolbachia density.
Do Individuals Make Sensible Health Insurance Decisions? Evidence from a Menu with Dominated Options

The recent expansion of health-plan choice has been touted as increasing competition and enabling people to choose plans that fit their needs. This study provides new evidence challenging these proposed benefits of expanded health-insurance choice. We examine health-insurance decisions of employees at a large U.S. firm where a new plan menu included a large share of financially dominated options. This menu offers a unique litmus test for evaluating choice quality since standard risk preferences and beliefs about one’s health cannot rationalize enrollment into the dominated plans. We find that a majority of employees – and in particular, older workers, women, and low earners – chose dominated options, resulting in substantial excess spending. Most employees would have fared better had they instead been enrolled in the single actuarially-best plan. In follow-up hypothetical-choice experiments, we observe similar choices despite far simpler menus. We find these choices reflect a severe deficit in health insurance literacy and naive considerations of health risk and price, rather than a sensible comparison of plan value. Our results challenge the standard practice of inferring risk attitudes and assessing welfare from insurance choices, and raise doubts whether recent health reforms will deliver their promised benefits.
Distribution and zonation pattern of mangrove forest in Shoal Bay Creek, Andaman Islands, India

Mangrove forest distributed throughout the coast of South Andaman Island varies from small patches to dense forest. In the field survey the various species of mangroves dominated in appropriate zones were identified. The coordinates of field survey were used to perform the supervised classification. Zones are classified from seaward to landward end and they are distributed as Seaward fringes, Tall Dense Rhizophora, Rhizophora-Ceriops dense, Xylocarpus mixed, Bruguiera Clumps and Landward Back mangroves. Total area of mangroves in Shoal Bay creek was estimated around 2912.97ha out of this 1688.72 ha of forest occupies by the Dense Rhizophora community and forms strong zonation in the entire creek. In the spices point of view Rhizophora mucronata and R. apiculata are the most dominant species of the creek which present in all the zones in all sub-tidal creeks of Shoal Bay.
The TESLA Broadcast Authentication Protocol

One of the main challenges of securing broadcast communication is source authentication, or enabling receivers of broadcast data to verify that the received data really originates from the claimed source and was not modified en route. This problem is complicated by mutually untrusted receivers and unreliable communication environments where the sender does not retransmit lost packets. This article presents the TESLA (Timed Efficient Stream Loss-tolerant Authentication) broadcast authentication protocol, an efficient protocol with low communication and computation overhead, which scales to large numbers of receivers, and tolerates packet loss. TESLA is based on loose time synchronization between the sender and the receivers. Despite using purely symmetric cryptographic functions (MAC functions), TESLA achieves asymmetric properties. We discuss a PKI application based purely on TESLA, assuming that all network nodes are loosely time synchronized.
Neurologic complications of carcinoid

We reviewed the records of all patients treated for carcinoid tumors at Memorial Sloan-Kettering Cancer Center from 1974 through 1984. Of 219 patients, 90 developed metastatic complications, and of these, 36 developed neurologic complications. Metastases, the most common neurologic complication, included epidural spinal cord compression (14 patients), intracranial metastases (13 patients), leptomeningeal metastases (1 patient), and peripheral nerve lesions (5 patients). Non-metastatic complications were hepatic encephalopathy (six patients), herpes zoster infection (two patients), cerebral infarction due to septic emboli (one patient), superior sagittal sinus thrombosis (one patient), and carcinoid myopathy (one patient). The carcinoid syndrome was seen in eight patients (4%). Response of neurologic metastases to conventional radiation therapy was usually favorable. We conclude that (1) the frequency and type of neurologic complications associated with carcinoid tumors are similar to those seen with other systemic cancers; (2) CNS metastases are relatively common in patients with metastatic carcinoid (29%); and (3) the carcinoid syndrome is less common than CNS metastasis.
Subjective Cognitive Complaints and the Role of Executive Cognitive Functioning in the Working Population: A Case-Control Study

Background Cognitive functioning is important for managing work and life in general. However, subjective cognitive complaints (SCC), involving perceived difficulties with concentration, memory, decision making, and clear thinking are common in the general and working population and can be coupled with both lowered well-being and work ability. However, the relation between SCC and cognitive functioning across the adult age-span, and in the work force, is not clear as few population-based studies have been conducted on non-elderly adults. Thus, the present study aimed to test the relation between SCC and executive cognitive functioning in a population-based sample of employees. Methods Participants were 233 employees with either high (cases) or low (controls) levels of SCC. Group differences in neuropsychological test performance on three common executive cognitive tests were analysed through a set of analyses of covariance tests, including relevant covariates. Results & Conclusions In line with the a priori hypotheses, a high level of SCC was associated with significantly poorer executive cognitive performance on all three executive cognitive tests used, compared to controls with little SCC. Additionally, symptoms of depression, chronic stress and sleeping problems were found to play a role in the relations between SCC and executive cognitive functioning. No significant associations remained after adjusting for all these factors. The current findings contribute to an increased understanding of what characterizes SCC in the work force and may be used at different levels of prevention of- and intervention for SCC and related problems with executive cognitive functioning.
Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties

The thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for the cortical column. L5b pyramidal cells have been the subject of extensive experimental and modeling studies, yet conductance-based models of these cells that faithfully reproduce both their perisomatic Na+-spiking behavior as well as key dendritic active properties, including Ca2+ spikes and back-propagating action potentials, are still lacking. Based on a large body of experimental recordings from both the soma and dendrites of L5b pyramidal cells in adult rats, we characterized key features of the somatic and dendritic firing and quantified their statistics. We used these features to constrain the density of a set of ion channels over the soma and dendritic surface via multi-objective optimization with an evolutionary algorithm, thus generating a set of detailed conductance-based models that faithfully replicate the back-propagating action potential activated Ca2+ spike firing and the perisomatic firing response to current steps, as well as the experimental variability of the properties. Furthermore, we show a useful way to analyze model parameters with our sets of models, which enabled us to identify some of the mechanisms responsible for the dynamic properties of L5b pyramidal cells as well as mechanisms that are sensitive to morphological changes. This automated framework can be used to develop a database of faithful models for other neuron types. The models we present provide several experimentally-testable predictions and can serve as a powerful tool for theoretical investigations of the contribution of single-cell dynamics to network activity and its computational capabilities.