Miracle-dz/UniFAR-FTUs huggingface dataset:
Breastfeeding duration, age of starting solids and high BMI risk and adiposity in Indian children.

This study utilized data from a prospective birth cohort study on 568 Indian children, to determine whether a longer duration of breastfeeding and later introduction of solid feeding were associated with a reduced higher body mass index (BMI) and less adiposity. Main outcomes were high BMI (>90th within-cohort sex-specific BMI percentile) and sum of skinfold thickness (triceps and subscapular) at age 5. Main exposures were breastfeeding (six categories from 1-4 to ≥21 months) and age of starting regular solid feeding (four categories from ≤3 to ≥6 months). Data on infant-feeding practices, socio-economic and maternal factors were collected by questionnaire. Birthweight, maternal and child anthropometry were measured. Multiple regression analysis that accounted for potential confounders demonstrated a small magnitude of effect for breastfeeding duration or introduction of solid feeds on the risk of high BMI but not for lower skinfold thickness. Breastfeeding duration was strongly negatively associated with weight gain (0-2 years) [adjusted β = -0.12 standard deviation, 95% confidence interval (CI): -0.19 to -0.05 per category change in breastfeeding duration, P = 0.001], and weight gain (0-2 years) was strongly associated with high BMI at 5 years (adjusted odds ratio = 3.8, 95% CI: 2.53-5.56, P < 0.001). In our sample, findings suggest that longer breastfeeding duration and later introduction of solids has a small reduction on later high BMI risk and a negligible effect on skinfold thickness. However, accounting for sampling variability, these findings cannot exclude the possibility of no effect at the population level.
Assessment of FPGA Implementations of One Sided Jacobi Algorithm for Singular Value Decomposition

Nowadays many application domains require an embedded electronic system for tactile data processing. Our research aims to implement a real time embedded electronic system based on tensorial kernel approach for tactile data processing. Singular value decomposition represents the more computational expensive algorithm for the tensorial kernel approach. This paper presents an assessment of FPGA implementations of one sided Jacobi algorithm for singular value decomposition. Designs are implemented to handle an arbitrary m×n matrix with fixed point arithmetic. The results figure out an efficient implementation suitable for real time embedded applications.
Nonlinear Coupling in the Human Motor System

The synchronous discharge of neuronal assemblies is thought to facilitate communication between areas within distributed networks in the human brain. This oscillatory activity is especially interesting, given the pathological modulation of specific frequencies in diseases affecting the motor system. Many studies investigating oscillatory activity have focused on same frequency, or linear, coupling between areas of a network. In this study, our aim was to establish a functional architecture in the human motor system responsible for induced responses as measured in normal subjects with magnetoencephalography. Specifically, we looked for evidence for additional nonlinear (between-frequency) coupling among neuronal sources and, in particular, whether nonlinearities were found predominantly in connections within areas (intrinsic), between areas (extrinsic) or both. We modeled the event-related modulation of spectral responses during a simple hand-grip using dynamic casual modeling. We compared models with and without nonlinear connections under conditions of symmetric and asymmetric interhemispheric connectivity. Bayesian model comparison suggested that the task-dependent motor network was asymmetric during right hand movements. Furthermore, it revealed very strong evidence for nonlinear coupling between sources in this distributed network, but interactions among frequencies within a source appeared linear in nature. Our results provide empirical evidence for nonlinear coupling among distributed neuronal sources in the motor system and that these play an important role in modulating spectral responses under normal conditions.
Proportion congruency effects: instructions may be enough

Learning takes time, namely, one needs to be exposed to contingency relations between stimulus dimensions in order to learn, whereas intentional control can be recruited through task demands. Therefore showing that control can be recruited as a function of experimental instructions alone, that is, adapting the processing according to the instructions before the exposure to the task, can be taken as evidence for existence of control recruitment in the absence of learning. This was done by manipulating the information given at the outset of the experiment. In the first experiment, we manipulated list-level congruency proportion. Half of the participants were informed that most of the stimuli would be congruent, whereas the other half were informed that most of the stimuli would be incongruent. This held true for the stimuli in the second part of each experiment. In the first part, however, the proportion of the two stimulus types was equal. A proportion congruent (PC) effect was found in both parts of the experiment, but it was larger in the second part. In our second experiment, we manipulated the proportion of the stimuli within participants by applying an item-specific design. This was done by presenting some color words most often in their congruent color, and other color words in incongruent colors. Participants were informed about the exact word-color pairings in advance. Similar to Experiment 1, this held true only for the second experimental part. In contrast to our first experiment, informing participants in advance did not result in an item-specific proportion effect, which was observed only in the second part. Thus our results support the hypothesis that instructions may be enough to trigger list-level control, yet learning does contribute to the PC effect under such conditions. The item-level proportion effect is apparently caused by learning or at least it is moderated by it.
Project-Based Learning and the Role of Learning Boundaries

This paper seeks to analyse the extent to which organizations can learn from projects by focusing on the relationship between projects and their organizational context. The paper highlights three dimensions of project-based learning: the practice-based nature of learning, project autonomy and knowledge integration. This analysis generates a number of propositions on the relationship between the learning generated within projects and its transfer to other parts of the organization. In particular, the paper highlights the ‘learning boundaries’ which emerge when learning within projects creates new divisions in practice. These propositions are explored through a comparative analysis of two case studies of construction projects. This analysis suggests that the learning boundaries which develop around projects reflect the nested nature of learning, whereby different levels of learning may substitute for each other. Learning outcomes in the cases can thus be analysed in terms of the interplay between organizational learning and project-level learning. The paper concludes that learning boundaries are an important constraint on attempts to exploit the benefits of project-based learning for the wider organization.
Lung inflammation caused by inhaled toxicants: a review

Exposure of the lungs to airborne toxicants from different sources in the environment may lead to acute and chronic pulmonary or even systemic inflammation. Cigarette smoke is the leading cause of chronic obstructive pulmonary disease, although wood smoke in urban areas of underdeveloped countries is now recognized as a leading cause of respiratory disease. Mycotoxins from fungal spores pose an occupational risk for respiratory illness and also present a health hazard to those living in damp buildings. Microscopic airborne particulates of asbestos and silica (from building materials) and those of heavy metals (from paint) are additional sources of indoor air pollution that contributes to respiratory illness and is known to cause respiratory illness in experimental animals. Ricin in aerosolized form is a potential bioweapon that is extremely toxic yet relatively easy to produce. Although the aforementioned agents belong to different classes of toxic chemicals, their pathogenicity is similar. They induce the recruitment and activation of macrophages, activation of mitogen-activated protein kinases, inhibition of protein synthesis, and production of interleukin-1 beta. Targeting either macrophages (using nanoparticles) or the production of interleukin-1 beta (using inhibitors against protein kinases, NOD-like receptor protein-3, or P2X7) may potentially be employed to treat these types of lung inflammation without affecting the natural immune response to bacterial infections.
Methodological Approach and Technological Framework to Break the Current Limitations of MOOC Model

A methodological approach and technological framework are proposed to improve learning outcomes in Massive Open Online Courses (MOOCs), taking into account the distinguishing features of this kind of massive courses over traditional online courses. The proposed methodology integrates the learning strategies of xMOOCs and cMOOCs with adaptivity and knowledge management capabilities. In order to test the learning results of the methodology and the need of supporting technological framework for it, a MOOC was made based on the methodological proposal and using a MOOC platform called MiriadaX. The quantitative results have improved considerably the MOOC completion rate (compared to the average of the rest of MOOC MiriadaX) and the qualitative results show a great satisfaction with the learning outcomes of the learners. However, the technological environment did not allow us develop all the methodological capabilities and it was one of the main concerns of the MOOC attendances. Therefore, from the analysis of collected data and considering the limitations of current MOOC technology platforms, a technological framework has been designed. It may incorporate the proposed methodology in an efficient and effective way. Based on this proposed technological framework, a MOOC platform has been developed and delivered, used by three Spanish Universities to offer MOOCs. This new platform and the supported technological framework have been tested with a first pilot with promising results.
Do galaxy global relationships emerge from local ones? The SDSS IV MaNGA surface mass density-metallicity relation

We present the stellar surface mass density versus gas metallicity (Σ*-Z) relation for more than 500 000 spatially resolved star-forming resolution elements (spaxels) from a sample of 653 disc galaxies included in the SDSS IV MaNGA survey. We find a tight relation between these local properties, with higher metallicities as the surface density increases. This relation extends over three orders of magnitude in the surface mass density and a factor of 4 in metallicity. We show that this local relationship can simultaneously reproduce two well-known properties of disc galaxies: their global mass–metallicity relationship and their radial metallicity gradients. We also find that the Σ*-Z relation is largely independent of the galaxy's total stellar mass and specific star formation rate (sSFR), except at low stellar mass and high sSFR. These results suggest that in the present-day universe local properties play a key role in determining the gas-phase metallicity in typical disc galaxies.
STRESS AND COPING

describe the anatomy of stress, especially two axes—hypothalamic-pituitary-adrenal and sympathetic-adrenal-medullary. We also know the sequence of stress hormones, which are produced during the different stages of stress and which are probably responsible for such events as stress-induced analgesia and other adaptive diseases. For the understanding of the mechanism of stress, it is necessary to take into account age, gender and inter-individual differences. Unfortunately the consequences of acute or chronic stress are very severe, and we are speaking about stress disorders. The main examples are gastrointestinal ulcers, cardiovascular diseases (angina pectoris), immune diseases and psychiatric disorders. Fortunately the defense and coping mechanisms are known and used in medical practice.
Thermal conduction in cosmological SPH simulations

Thermal conduction in the intracluster medium has been proposed as a possible heating mechanism for offsetting central cooling losses in rich clusters of galaxies. However, because of the coupled non-linear dynamics of gas subject to radiative cooling and thermal conduction, cosmological hydrodynamical simulations are required to predict reliably the effects of heat conduction on structure formation. In this study, we introduce a new formalism to model conduction in a diffuse ionized plasma using smoothed particle hydrodynamics (SPH), and we implement it in the parallel TreePM/SPH-code GADGET-2. We consider only isotropic conduction and assume that magnetic suppression can be described in terms of an effective conductivity, taken as a fixed fraction of the temperature-dependent Spitzer rate. We also account for saturation effects in low-density gas. Our formulation manifestly conserves thermal energy even for individual and adaptive time-steps, and is stable in the presence of small-scale temperature noise. This allows us to evolve the thermal diffusion equation with an explicit time integration scheme along with the ordinary hydrodynamics. We use a series of simple test problems to demonstrate the robustness and accuracy of our method. We then apply our code to spherically symmetric realizations of clusters, constructed under the assumptions of hydrostatic equilibrium and a local balance between conduction and radiative cooling. While we confirm that conduction can efficiently suppress cooling flows for an extended period of time in these isolated systems, we do not find a similarly strong effect in a first set of clusters formed in self-consistent cosmological simulations. However, their temperature profiles are significantly altered by conduction, as is the X-ray luminosity.
K-Nearest Neighbor-Based for Online Baseline Identification

A signature is the writerpsilas self representation. It contains many features; one of it is its baseline. The information contained in the baseline is known to be used as a precondition for subsequent handwriting or signature recognition algorithms and many researches regarding it has been done using off-line data. This research focuses on identifying the signature baseline by applying the concept of k-nearest neighbor. From the algorithm developed, it was found that out of 100 signatures from the database, 85% of the signature baselines were able to be identified.
Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy

Doxorubicin (DOX) is one of the most effective cytotoxic anticancer drugs used for the treatment of hematological malignancies, as well as a broad range of solid tumors. However, the clinical applications of this drug have long been limited due to its severe dose-dependent toxicities. Therefore, DOX derivatives and analogs have been developed to address this issue. A type of DOX prodrug, cleaved by cathepsin B (Cat B), which is highly upregulated in malignant tumors and premalignant lesions, has been developed to achieve a higher DOX concentration in tumor tissue and a lower concentration in normal tissue, so as to enhance the efficacy and reduce toxicity to normal cells. In this review, we focused on Cat B-cleavable DOX prodrugs and discussed the efficacy of these prodrugs, demonstrated by preclinical and clinical developments.
Chronic pain in survivors of childhood cancer: a developmental model of pain across the cancer trajectory.

Over the past 50 years, advances in treatment have resulted in significant improvements in pediatric cancer survival rates. Such improvements have been due, in part, tomore aggressive treatment protocols, which in addition to the disease itself and the psychosocial impact of the disease, place survivors at risk of developing an array of late effects, including neurocognitive impairment, chronic health conditions, fatigue and poor sleep, social impairment, and psychological distress. Despite elevated and clinically significant pain being common among youthduringandafter cancer treatment, andevidence suggesting that pain persists into adulthood, pain has remained understudied relative to other late effects. In recognition of this overlooked area, authors have recently suggested that a prevention framework must be applied to pain in pediatric cancer survivors. Althoughwe agree with this stance, we also see the need to take a step beyond to consider what is known about pain in pediatric cancer survivors, including adolescent, young adult, and adult survivors. In this topical review, we aim to (1) nonsystematically review the current empirical literature on pain in survivors of childhood cancer, highlighting gaps and limitations; (2) draw from the extant literature in related research areas (pediatric chronic noncancer pain and pain in adult-onset cancer survivors) to indicate how the identified gaps and limitations can be addressed; and (3) combine findings from aims 1 and 2 to provide a research and clinical agenda to guide future research on pain in childhood cancer survivors.
Gas formation and biological effects of biodegradable magnesium in a preclinical and clinical observation

Abstract Magnesium alloys are biodegradable metals receiving increasing attention, but the clinical applications of these materials are delayed by concerns over the rapid corrosion rate and gas formation. Unlike corrosion, which weakens mechanical properties, the gas formation issue has received little attention. Therefore, we evaluated the gas formation and biological effects for Mg implants through preclinical (immersed in Earle’s balanced salt solution and in vivo) and clinical studies. The immersion test examined the gas volume and composition. The in vivo study also examined gas volume and histological analysis. The clinical study examined the gas volume and safety after Mg screw metatarsal fixation. Gas was mainly composed of H2, CO and CO2. Maximum volumes of gas formed after 5 days for in vivo and 7 days in clinical study. Within the clinical examination, two superficial wound complications healed with local wound care. Osteolytic lesions in the surrounding metaphysis of the Mg screw insertion developed in all cases and union occurred at 3 months. Mg implants released gas with variable volumes and composition (H2, CO, and CO2), with no long-term toxic effects on the surrounding tissue. The implants enabled bone healing, although complications of wound breakdown and osteolytic lesions developed.
Comparing Functional Outcome of Triangle Tilt Surgery Performed Before Versus After Two Years of Age

Background: Many patients each year who are born with obstetric brachial plexus injuries eventually do not achieve complete recovery. As a result of the primary nerve injuries, these patients will often develop bony deformities involving the shoulder joint as a secondary consequence. The triangle tilt surgery has been shown to be an effective procedure to correct these deformities and has been performed on patients ranging in age from less than a year old to adolescence. The purpose of this retrospective study is to compare outcomes of triangle tilt surgery performed on patients before the age of 2 years versus after 2 years of age to determine an optimal age to operate on these children. Methods: 36 patients with deformities developed secondarily from the initial obstetric brachial plexus injury in this study were divided into 2 groups. Group 1, those who had undergone triangle tilt surgery at < 2 yrs of age (16 patients). Group 2, those who were operated at > 2 yrs of age (20 patients). Group 1 age range: 9 months to 23 months, average: 18 months. Group 2 age range: 26 months to 9 years, average: 6 years. Results: Significant differences were found between the 2 groups (0-2 yrs vs > 2yrs) in regards to overall changes (pre- to post-op) in Mallet score, external rotation score, hand-to-mouth score, and supination angle. Discussion: This study demonstrates that triangle tilt surgery had better outcomes on clinical functioning if performed before the age of 2 years, however, improvement in clinical functioning can still be achieved if the triangle tilt surgery is performed after the age of 2 years as well. A possible mechanism to explain this phenomenon is the increased potential for anatomical remodeling if the triangle tilt surgery is performed at a younger age, thereby leading to significant functional improvement.
[Determinants of early sexual initiation in the Pelotas birth cohort from 1982 to 2004-5, Southern Brazil].

OBJECTIVE To analyze social determinants of early sexual initiation among young adults from a birth cohort. METHODS Individuals from the 1982 birth cohort (N=4,297) were interviewed in 2004-5, city of Pelotas, Southern Brazil. Early sexual initiation (<13 years of age) was the outcome. Descriptive and stratified analyses were performed according to sex. Variables analyzed were family income in 1982, ethnicity, young adult's level of education and change in income (between 1982 and 2004-5). Ethnographic data were used to complement result analysis. RESULTS Prevalence of early sexual initiation was higher among black and mixed men, and those with low level of education and low family income in 1982 and 2004-5. More traditional male sexual role requirements, such as virility and sexual initiative, showed more repercussion and adherence from an early age among men. Young family women with higher income and level of education tended to delay their sexual initiation. Imposition of traditional values was found to influence early sexual initiation among men and women with lower level of education and income. CONCLUSIONS Results found re-established the economic factor as a determinant of behavior or uses of sexuality for both sexes. To focus on political efforts that help the economically disadvantaged to have opportunities and egalitarian future perspectives is an important strategy for health outcomes.
The structure of online diffusion networks

Models of networked diffusion that are motivated by analogy with the spread of infectious disease have been applied to a wide range of social and economic adoption processes, including those related to new products, ideas, norms and behaviors. However, it is unknown how accurately these models account for the empirical structure of diffusion over networks. Here we describe the diffusion patterns arising from seven online domains, ranging from communications platforms to networked games to microblogging services, each involving distinct types of content and modes of sharing. We find strikingly similar patterns across all domains. In particular, the vast majority of cascades are small, and are described by a handful of simple tree structures that terminate within one degree of an initial adopting "seed. " In addition we find that structures other than these account for only a tiny fraction of total adoptions; that is, adoptions resulting from chains of referrals are extremely rare. Finally, even for the largest cascades that we observe, we find that the bulk of adoptions often takes place within one degree of a few dominant individuals. Together, these observations suggest new directions for modeling of online adoption processes.