Miracle-dz/UniFAR-FTUs huggingface dataset:
Gender-Specific Vocal Dysfunctions in Parkinson's Disease: Electroglottographic and Acoustic Analyses

Electroglottographic (EGG) and acoustic recordings were obtained during sustained vowel production in men and women suffering from Parkinson's disease (PD). The computed EGG spectrograms allowed us to differentiate various kinds of phonatory disturbances: intervals with subharmonic energy (“low-frequency segments”), “noise-like regions,” and abrupt shifts of fundamental frequency (F0). Female PD subjects presented with a significantly increased portion of subharmonic segments and with significantly more abrupt F0 shifts as compared to both controls and male PD subjects. Presumably, these alterations in spectral energy distribution reflect different oscillatory modes of the glottal source. Thus, PD seems to have a differential impact on phonation in men and women. Conceivably, these gender-specific vocal dysfunctions are determined by the well-known sexual dimorphism of laryngeal size.
Bacteriology of Otitis Media in Ghana

Les germes identifies sont strep-pyogenes (25,5%). Ps. aeruginosa (18,5%) step. aureus (94%). Corynebacterium (12%). Coliformes (11%), Proteus (7%), Staph. epidermides (7%) Strept pyogenes (non groupe A de Cancsfield) (5%). La penicilline est le traitement d'election a moins que des bacillus gram-negatifs comme Pseudomonas soient cultives
Action Contribution to Competence Judgments: The Use of the Journey Schema

The current research considered the question of how performing an action, or merely preparing the body for action, can have an impact on social judgments related to person perception. Participants were asked to ascribe competence and warmth characteristics to a target person by reading a metaphoric text while their body was manipulated to be prepared for the processing of action-congruent information. In Experiment 1, participants whose forward body action matched the metaphoric action described in the text ascribed more competence characteristics to a politician than did control participants. In Experiment 2, participants whose body was merely prepared for forward movement also ascribed more competence characteristics to a politician than did control participants. In addition, the data from Experiment 2 ruled out an alternative non-embodied explanation (i.e., that effect is due to basic associative processes) grounded in the existing literatures on attitudes by demonstrating that body manipulation had no effect on competence when a non-metaphoric text was used. Finally, no evidence was found that body manipulation affects warmth judgments. These studies converge in demonstrating that forward body movements enhance the favorability of competence judgments when these match the metaphoric forward movements described by text.
How to Create a Mind: The Secret of Human Thought Revealed

The bestselling author of The Singularity Is Near explores the limitless potential of reverse-engineering the human brain Ray Kurzweil is arguably todays most influential futurist. In How to Create a Mind, he presents a provocative exploration of the most important project in the human-machine civilization: reverse-engineering the brain to understand precisely how it functions and using that knowledge to create even more intelligent machines. Kurzweil discusses how the brain works, how the mind emerges, brain-computer interfaces, and the implications of vastly increasing the powers of our intelligence to address the worlds problems. Certain to be one of the most widely discussed and debated science books of the year, How to Create a Mind is sure to take its place alongside Kurzweils previous classics.
Tests of the Accelerating Universe with Near-Infrared Observations of a High-Redshift Type Ia Supernova

We have measured the rest-frame B-, V-, and I-band light curves of a high-redshift type Ia supernova (SN Ia), SN 1999Q (z = 0.46), using the Hubble Space Telescope (HST) and ground-based near-infrared detectors. A goal of this study is the measurement of the color excess, EB-I, a sensitive indicator of interstellar or intergalactic dust, which could affect recent cosmological measurements from high-redshift SNe Ia. Our observations disfavor a 30% opacity of SN Ia visual light by dust as an alternative to an accelerating universe. This statement applies to both Galactic-type dust (rejected at the 3.4 σ confidence level) and grayer dust (grain size > 0.1 μm, rejected at the 2.3-2.6 σ confidence level) as proposed by Aguirre. The rest-frame I-band light curve shows the secondary maximum 1 month after the B maximum typical of nearby SNe Ia of normal luminosity, providing no indication of evolution as a function of redshift out to z ≈ 0.5. An expanded set of similar observations could improve the constraints on any contribution of extragalactic dust to the dimming of high-redshift SNe Ia.
Exploring Query Auto-Completion and Click Logs for Contextual-Aware Web Search and Query Suggestion

Contextual data plays an important role in modeling search engine users' behaviors on both query auto-completion (QAC) log and normal query (click) log. User's recent search history on each log has been widely studied individually as the context to benefit the modeling of users' behaviors on that log. However, there is no existing work that explores or incorporates both logs together for contextual data. As QAC and click logs actually record users' sequential behaviors while interacting with a search engine, the available context of a user's current behavior based on the same type of log can be strengthened from the user's recent search history shown on the other type of log. Our paper proposes to model users' behaviors on both QAC and click logs simultaneously by utilizing both logs as the contextual data of each other. The key idea is to capture the correlation between users' behavior patterns on both logs. We model such correlation through a novel probabilistic model based on the Latent Dirichlet allocation (LDA) model. The learned users' behavior patterns on both logs are utilized to address not only the application of query auto-completion on QAC logs, but also the click prediction and relevance ranking of web documents on click logs. Experiments on real-world logs demonstrate the effectiveness of the proposed model on both applications.
Using Mobile Phones for Activity Recognition in Parkinson’s Patients

Mobile phones with built-in accelerometers promise a convenient, objective way to quantify everyday movements and classify those movements into activities. Using accelerometer data we estimate the following activities of 18 healthy subjects and eight patients with Parkinson’s disease: walking, standing, sitting, holding, or not wearing the phone. We use standard machine learning classifiers (support vector machines, regularized logistic regression) to automatically select, weigh, and combine a large set of standard features for time series analysis. Using cross validation across all samples we are able to correctly identify 96.1% of the activities of healthy subjects and 92.2% of the activities of Parkinson’s patients. However, when applying the classification parameters derived from the set of healthy subjects to Parkinson’s patients, the percent correct lowers to 60.3%, due to different characteristics of movement. For a fairer comparison across populations we also applied subject-wise cross validation, identifying healthy subject activities with 86.0% accuracy and 75.1% accuracy for patients. We discuss the key differences between these populations, and why algorithms designed for and trained with healthy subject data are not reliable for activity recognition in populations with motor disabilities.
Socioeconomic deprivation and barriers to live-donor kidney transplantation: a qualitative study of deceased-donor kidney transplant recipients

Objectives Socioeconomically deprived individuals with renal disease are less likely to receive a live-donor kidney transplant than less-deprived individuals. This qualitative study aimed to identify reasons for the observed socioeconomic disparity in live-donor kidney transplantation. Design A qualitative study using face-to-face in-depth semistructured interviews. Setting A UK tertiary renal referral hospital and transplant centre. Participants Purposive sampling was used to select deceased-donor transplant recipients from areas of high socioeconomic deprivation (SED) (19 participants), followed by a low SED comparison group (13 participants), aiming for maximum diversity in terms of age, gender, ethnicity, primary renal disease and previous renal replacement therapy. Methods Participants were interviewed following their routine transplant clinic review. Interviews were digitally audio-recorded and transcribed verbatim. Transcripts were coded using NVivo software and analysed using the constant comparison method described in Grounded Theory. Results Themes common and distinct to each socioeconomic group emerged. 6 themes appeared to distinguish between individuals from areas of high and low SED. 4 themes were distinct to participants from areas of high SED: (1) Passivity, (2) Disempowerment, (3) Lack of social support and (4) Short-term focus. 2 themes were distinct to the low SED group: (1) Financial concerns and (2) Location of donor. Conclusions Several of the emerging themes from the high SED individuals relate to an individual's lack of confidence and skill in managing their health and healthcare; themes that are in keeping with low levels of patient activation. Inadequate empowerment of socioeconomically deprived individuals by healthcare practitioners was also described. Financial concerns did not emerge as a barrier from interviews with the high SED group. Interventions aiming to redress the observed socioeconomic inequity should be targeted at both patients and clinical teams to increase empowerment and ensure shared decision-making.
CO2‐forced evolution of plant gas exchange capacity and water‐use efficiency over the Phanerozoic

The capacity of plants to fix carbon is ultimately constrained by two core plant attributes: photosynthetic biochemistry and the conductance to CO2 diffusion from the atmosphere to sites of carboxylation in chloroplasts, predominantly stomatal conductance. Analysis of fossilized plant remains shows that stomatal density (number per unit area, D) and size (length by width, S) have fluctuated widely over the Phanerozoic Eon, indicating changes in maximum stomatal conductance. Parallel changes are likely to have taken place in leaf photosynthetic biochemistry, of which maximal rubisco carboxylation rate, Vcmax is a central element. We used measurements of S and D from fossilized plant remains spanning the last 400 Myr (most of the Phanerozoic), together with leaf gas exchange data and modeled Phanerozoic trends in atmospheric CO2 concentration, [CO2]a, to calibrate a [CO2]a‐driven model of the long‐term environmental influences on S, D and Vcmax. We show that over the Phanerozoic large changes in [CO2]a forced S, D and Vcmax to co‐vary so as to reduce the impact of the change in [CO2]a on leaf CO2 assimilation for minimal energetic cost and reduced nitrogen requirements. Underlying this is a general negative correlation between S and D, and a positive correlation between water‐use efficiency and [CO2]a. Furthermore, the calculated steady rise in stomatal conductance over the Phanerozoic is consistent with independent evidence for the evolution of plant hydraulic capacity, implying coordinated and sustained increase in gas exchange capacity and hydraulic capacity parallel long‐term increases in land plant diversity.
Transesophageal Electrophysiologic Study to Determine the Inducibility After Successful Ablation of Supraventricular Tachycardia in Children

Background: Radiofrequency ablation has become first‐line therapy for supraventricular tachycardia in all age groups, but there has been a concern regarding the long‐term effectiveness of the procedure in children. This study aimed to determine the inducibility after successful ablation of supraventricular tachycardia in children; assessment was performed using a transesophageal electrophysiologic study.
Lower limb amputation in Jos, Nigeria.

OBJECTIVE To determine the pattern of lower limb amputation (LLA) and highlight preventable causes in our hospital. DESIGN A retrospective study. SETTING University Teaching Hospital, Jos, Nigeria. SUBJECTS Eighty seven patients who had LLA over a five and a half year period. There were 62 males and 25 females aged between three and 83 years (mean+/-SD = 44.5+/-21.1). MAIN OUTCOME MEASURES Indications, morbidity and mortality. RESULTS A total of 94 LLA were performed in the 87 patients managed. Trauma, diabetic foot sepsis and malignant conditions of the limb were the main indications for LLA in 26(29.9%), 23(26.4%) and 20(23%) patients respectively. Others were peripheral vascular gangrene (PVG) in eight (9.2%) patients; chronic osteomyelitis, three (3.5%); chronic leg ulcers, three (3.5%); Ainhum, three (3.5%) and snake bite in one patient (1.1%). Above knee amputation (AKA) was the most common procedure performed (48.9%) followed by below knee amputation (BKA) in 37.2%. There were 11 deaths (12.6%), out of which eight were due to sepsis with multiple organ failure following diabetic foot sepsis, two cases of clostridial myonecrosis complicating compound fractures and a case of metastatic osteosarcoma in a child. CONCLUSION Majority of the cases of LLA could have been avoided with early presentation and appropriate management. A case is made for community health education on the need for early presentation to hospital for limb lesions.
GENERIC COMMUTATIVE SEPARABLE ALGEBRAS AND COSPANS OF GRAPHS

We show that the generic symmetric monoidal category with a commu- tative separable algebra which has a Σ-family of actions is the category of cospans of finite Σ-labelled graphs restricted to finite sets as objects, thus providing a syntax for automata on the alphabet Σ. We use this result to produce semantic functors for Σ- automata.
Understanding touch

Current touch devices, such as capacitive touchscreens are based on the implicit assumption that users acquire targets with the center of the contact area between finger and device. Findings from our previous work indicate, however, that such devices are subject to systematic error offsets. This suggests that the underlying assumption is most likely wrong. In this paper, we therefore revisit this assumption. In a series of three user studies, we find evidence that the features that users align with the target are visual features. These features are located on the top of the user's fingers, not at the bottom, as assumed by traditional devices. We present the projected center model, under which error offsets drop to 1.6mm, compared to 4mm for the traditional model. This suggests that the new model is indeed a good approximation of how users conceptualize touch input. The primary contribution of this paper is to help understand touch-one of the key input technologies in human-computer interaction. At the same time, our findings inform the design of future touch input technology. They explain the inaccuracy of traditional touch devices as a -Sparallax- artifact between user control based on the top of the finger and sensing based on the bottom side of the finger. We conclude that certain camera-based sensing technologies can inherently be more accurate than contact area-based sensing.
Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: the European Organisation for Research and Treatment of Cancer Chronotherapy Group.

PURPOSE In two previous randomized trials, the adjustment of chemotherapy delivery to circadian rhythms improved tolerability and anticancer activity compared with constant-rate infusion during 5 days in patients with metastatic colorectal cancer. PATIENTS AND METHODS For this multicenter randomized trial, it was hypothesized that a chronomodulated infusion of fluorouracil, leucovorin, and oxaliplatin for 4 days (chronoFLO4) would improve survival by 10% compared with conventional 2-day delivery of the same drugs (FOLFOX2). Patients were treated every 2 weeks with intrapatient dose escalation. RESULTS Baseline characteristics were similar in both arms for the 564 patients (36 institutions, 10 countries). Median survival was 19.6 months (95% confidence limit [CL] = 18.2, 21.2) with chronoFLO4 and 18.7 months with FOLFOX2 (95% CL = 17.7, 21.0; P = .55). The main dose-limiting toxicities were diarrhea for chronoFLO4 and neutropenia for FOLFOX2. The analysis of survival predictors showed that sex was the single most important factor (P = .001). In women, the risk of an earlier death with chronoFLO4 was increased by 38% compared with FOLFOX2, with median survival times of 16.3 and 19.1 months (P = .03), respectively. In men, the risk of death was decreased by 25% with chronoFLO4 compared with FOLFOX2, with median survival times of 21.4 and 18.3 months (P = .02), respectively. CONCLUSION Both regimens achieved similar median survival times more than 18 months with an acceptable toxicity. The chronomodulated schedule produced a survival advantage over FOLFOX in men. The strong sex dependency of optimal scheduling of fluorouracil, leucovorin, and oxaliplatin calls for translational investigations of determinants related to the patient's molecular clock.
“I Can Also Serve as an Inspiration”: A Qualitative Study of the TB&Me Blogging Experience and Its Role in MDR-TB Treatment

Background In 2011, Médecins Sans Frontières (MSF) established a blogging project, “TB&Me,” to enable patients with multidrug-resistant tuberculosis (MDR-TB) to share their experiences. By September 2012, 13 MDR-TB patients had blogged, either directly or with assistance, from the UK, Australia, Philippines, Swaziland, Central African Republic, Uganda, South Africa, India, and Armenia. Due to the lack of research on the potential for social media to support MDR-TB treatment and the innovative nature of the blog, we decided to conduct a qualitative study to examine patient and staff experiences. Our aim was to identify potential risks and benefits associated with blogging to enable us to determine whether social media had a role to play in supporting patients with MDR-TB. Methods and Findings Participants were identified and selected purposively. TB&Me bloggers, project staff, MSF headquarters staff involved with TB and WHO European Region TB policy advisors were invited to participate in a semi-structured interview. Twenty interviews were conducted (five with bloggers). Data analysis drew upon principles of grounded theory, with constant comparison of data, cases and categories, and attention to deviant cases. We found that the TB&Me blog was associated with identified health benefits, with no reported instances of harm. There were three main findings: blogging was reported as useful for adherence to DR-TB treatment and supportive of the treatment-taking process by all bloggers and project staff; blogging provided support to patients (peer support, shared experience and reduction in isolation); and the blog was perceived as giving patients strength and voice. Conclusion The TB&Me blog was seen to be associated with positive identified health and emotional benefits. Component 5 of the Stop TB Global Plan highlights the importance of empowering TB patients and communities. Blogging could be a useful tool to help achieve that ambition.
Dendritic cells genetically engineered to simultaneously express endogenous tumor antigen and granulocyte macrophage colony-stimulating factor elicit potent therapeutic antitumor immunity.

Recently, several studies have shown that vaccine therapy using dendritic cells (DCs) genetically engineered to express a surrogate tumor antigen can effectively induce antitumor immunity. In this study, murine bone marrow DCs were adenovirally transduced with murine endogenous tumor antigen gp70 expressed in CT26 cells and granulocyte macrophage colony-stimulating factor (GM-CSF), and we examined whether antigen-specific CTL responses and therapeutic immunity could be induced in mice immunized with those genetically modified DCs. The cytotoxic activity against CT26 in mice immunized with gp70-transduced DCs was significantly higher than that in control (P < 0.01) and was enhanced by GM-CSF-cotransduction (P < 0.001). GM-CSF gene transfer into DCs expressing tumor-associated antigen enhances CC chemokine receptor 7 expression on DCs, leading to improved migratory capacity of DCs to draining lymph nodes. Consequently, an effective antitumor immune response would be induced. Vaccination using gp70-transduced DCs provided remarkable therapeutic efficacy in s.c. models. Moreover, it could be sufficiently augmented by GM-CSF-cotransduction of DCs. These results support that vaccination therapy using DCs simultaneously transduced with tumor-associated antigen can elicit potent CTL response, and GM-CSF-cotransduction of DCs could optimize therapeutic response. Further investigation is needed to optimize this vaccine therapy to achieve the obvious benefit in clinical application.
The Decoupling of "Explicit"and "Implicit" Processing in Neuropsychological Disorders: Insights into the Neural Basis of Consciousness?

A key element of the distinction between explicit and implicit cognitive functioning is the presence or absence of conscious awareness. In this review, we consider the proposal that neuropsychological disorders can best be considered in terms of a decoupling between preserved implicit or unconscious processing and impaired explicit or conscious processing. Evidence for dissociations between implicit and explicit processes in blindsight, amnesia, object agnosia, prosopagnosia, hemi-neglect, and aphasia is examined. The implications of these findings for a) our understanding of a variety of neuropsychological disorders, b) the conceptualization of normal cognitive functioning, c) the neural basis of consciousness, and d) the clinical rehabilitation of brain-injured individuals are also discussed.
Gender and prestige in Swedish academia: Exploring senior management in universities and university colleges

ABSTRACT This article highlights the multifaceted character of the Swedish higher education sector and investigates senior academic management positions from a gender perspective using theories about an academic prestige economy and academic capitalism. The focus is on an aspect often overseen in research on Swedish academia: the distinction between universities and university colleges. The analysis draws on interviews with 22 women in senior management positions in Swedish higher education and a quantitative mapping of the Vice-Chancellor and Pro-Vice-Chancellor positions in universities and university colleges between 1990 and 2015. The results illustrate that the academic prestige economy is interwoven with both gender and academic capitalism and produce different working conditions and requirements for senior managers at universities and university colleges.