Miracle-dz/UniFAR-FTUs huggingface dataset:
Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain

Abstract Objective To determine the efficacy and safety of topical rubefacients containing salicylates in acute and chronic pain. Data sources Electronic databases and manufacturers of salicylates. Study selection Randomised double blind trials comparing topical rubefacients with placebo or another active treatment, in adults with acute or chronic pain, and reporting dichotomous information, around a 50% reduction in pain, and analyses at one week for acute conditions and two weeks for chronic conditions. Data extraction Relative benefit and number needed to treat, analysis of adverse events, and withdrawals. Data synthesis Three double blind placebo controlled trials had information on 182 patients with acute conditions. Topical salicylate was significantly better than placebo (relative benefit 3.6, 95% confidence interval 2.4 to 5.6; number needed to treat 2.1, 1.7 to 2.8). Six double blind placebo controlled trials had information on 429 patients with chronic conditions. Topical salicylate was significantly better than placebo (relative benefit 1.5, 1.3 to 1.9; number needed to treat 5.3, 3.6 to 10.2), but larger, more valid studies were without significant effect. Local adverse events and withdrawals were generally rare in trials that reported them. Conclusions Based on limited information, topically applied rubefacients containing salicylates may be efficacious in the treatment of acute pain. Trials of musculoskeletal and arthritic pain suggested moderate to poor efficacy. Adverse events were rare in studies of acute pain and poorly reported in those of chronic pain. Efficacy estimates for rubefacients are unreliable owing to a lack of good clinical trials.
Transfer Learning for Reinforcement Learning Domains: A Survey

The reinforcement learning paradigm is a popular way to address problems that have only limited environmental feedback, rather than correctly labeled examples, as is common in other machine learning contexts. While significant progress has been made to improve learning in a single task, the idea of transfer learning has only recently been applied to reinforcement learning tasks. The core idea of transfer is that experience gained in learning to perform one task can help improve learning performance in a related, but different, task. In this article we present a framework that classifies transfer learning methods in terms of their capabilities and goals, and then use it to survey the existing literature, as well as to suggest future directions for transfer learning work.
DMT Optimal Cooperative Protocols with Destination-Based Selection of the Best Relay

We design a cooperative protocol in the context of wireless mesh networks in order to increase the reliability of wireless links. Destination terminals ask for cooperation when they fail in decoding data frames transmitted by source terminals. In that case, each destination terminal D calls a specific relay terminal B with a signaling frame to help its transmission with source terminal S. To select appropriate relays, destination terminals maintain tables of relay terminals, one for each possible source address. These tables are constituted by passively overhearing ongoing transmissions. Hence, when cooperation is needed between S and D, and when a relay B is found by terminal D in the relay table associated with terminal S, the destination terminal sends a negative acknowledgment frame that contains the address of B. When the best relay B has successfully decoded the source message, it sends a copy of the data frame to D using a selective decode-and-forward transmission scheme. The on-demand approach allows maximization of the spatial multiplexing gain and the cooperation of the best relay allows maximization of the spatial diversity order. Hence, the proposed protocol achieves optimal diversity-multiplexing trade-off performance. Moreover, this performance is achieved through a collision-free selection process.
Spectral-Domain Formulation of Electromagnetic Scattering from Circular Cylinders Located Near Periodic Cylinder Array

This paper considers a periodic circular cylinder array with additional cylinders and formulates the electromagnetic scattering problem of this imperfectly periodic structure. Generally, the flelds in imperfectly periodic structures have continuous spectra, and the spectral-domain approaches require appropriate discretization schemes in many cases. The present formulation is based on the pseudo-periodic Fourier transform and the discretization scheme can be considered only inside the Brillouin zone.
Microtubule dynamics in axons and dendrites

We have investigated the stability, α‐tubulin composition, and polarity orientation of microtubules (MTs) in the axons and dendrites of cultured sympathetic neurons. MT stability was evaluated in terms of sensitivity to nocodazole, a potent anti‐MT drug. Nocodazole sensitivity was assayed by quantifying the loss of MT polymer as a function of time in 2 μg/ml of the drug. MTs in the axon and the dendrite exhibit striking similarities in their drug sensitivity. In both types of neurites, the kinetics of MT loss are biphasic, and are consistent with the existence of two types of MT polymer that depolymerize with half‐times of ≈︁3.5 min and ≈︁130 min. We define the more rapidly depolymerizing polymer as drug‐labile and the more slowly depolymerizing polymer as drug‐stable. The proportion of MT polymer that is drug‐stable is greater in axons (58%) than in dendrites (25%). On the basis of current understanding of the mechanism of action of nocodazole, we suggest that the drug‐labile and drug‐stable polymer observed in both axons and dendrites correspond to two distinct types of polymer that differ in their relative rates of turnover in vivo. In a previous study, we established that in the axon, these drug‐stable and drug‐labile types of MT polymer exist in the form of distinct domains on individual MTs, with the labile domain situated at the plus end of the stable domain (Baas and Black, J Cell Biol 111:495–509, 1990).
Natural antibodies to the human T cell lymphoma virus in patients with cutaneous T cell lymphomas

Sera from patients with cutaneous T cell lymphoma and leukemia were screened for the presence of natural antibody to the human T cell lymphoma (leukemia) virus, HTLVCR, using a solid-phase radioimmunoassay. Sera from two patients, including patient CR, from whose cultured T lymphoblastic cell line (HUT102), the retrovirus HTLVCR was isolated, reacted specifically with proteins of HTLVCR. Serum from patient CR also reacted specifically with proteins of HTLVMB, an independent but highly related retroviral isolate from a patient with Sezary T cell leukemia. The specificity for HTLVCR proteins was demonstrated by solid-phase immunocompetition assays and competition radioimmunoprecipitation assays. Analysis of radioimmunoprecipitates indicated that the natural antibodies were directed against HTLVCR core proteins with molecular weights of 24,000 and 19,000 (p24 and p19). Whereas the serum reactivities for HTLVCR proteins were shown to be highly specific, additional reactivities seen against proteins of animal retroviruses including GaLV, SSV, FeLV, and BaEV were clearly shown not to be viral specific but rather were due to reactivity with cellular antigens contaminating the viral preparations or with related antigens present in fetal calf serum. These results demonstrating natural antibodies to HTLVCR provide the first evidence for a specific antibody response to a retrovirus in humans.
Online aggregation for large MapReduce jobs

In online aggregation, a database system processes a user's aggregation query in an online fashion. At all times during processing, the system gives the user an estimate of the final query result, with the confidence bounds that become tighter over time. In this paper, we consider how online aggregation can be built into a MapReduce system for large-scale data processing. Given the MapReduce paradigm's close relationship with cloud computing (in that one might expect a large fraction of MapReduce jobs to be run in the cloud), online aggregation is a very attractive technology. Since large-scale cloud computations are typically pay-as-you-go, a user can monitor the accuracy obtained in an online fashion, and then save money by killing the computation early once sufficient accuracy has been obtained.
Geometry of the Pfaff lattices

Pfaff lattice was introduced by Adler and van Moerbeke to describe the partition functions for the random matrix models of GOE and GSE type. The partition functions of those matrix models are given by the Pfaffians of certain skew-symmetric matrices called the moment matrices, and they are the $\tau$-functions of the Pfaff lattice. In this paper, we study a finite version of the Pfaff lattice equation as a Hamiltonian system. In particular, we prove the complete integrability in the sense of Arnold-Liouville, and using a moment map, we describe the real isospectral varieties of the Pfaff lattice. The image of the moment map is a convex polytope whose vertices are identified as the fixed points of the flow generated by the Pfaff lattice.
Paternal Age and General Cognitive Ability—A Cross Sectional Study of Danish Male Conscripts

Objectives Offspring of older men have impaired cognitive ability as children, but it is unclear if this impairment persists into adulthood. The main objective of this study was to explore the association between paternal age at offspring birth and general cognitive ability as young adults. Design Population-based cross-sectional study with prospectively collected data on obstetric factors and parental education. Setting Nationwide Danish sample. Participants Male conscripts (n = 169,009). Primary and secondary outcome measures General cognitive ability as assessed by the Børge Priens test score, an intelligence test with components related to logical, verbal, numerical and spatial reasoning. Results We observed an inverse U-shaped association between paternal age and general cognitive ability (slightly lower test scores in the offspring of fathers aged less than 25 years and older than 40 years, compared with fathers aged 25 to 29 years). However, after adjustment for maternal age, parental education and birth order the shape of the association changed. Offspring of fathers younger than 20 still showed slightly lower cognitive ability (-1.11 (95% CI -1.68 to -0.54)), but no significant impairments were identified in the men whose fathers were older than 29 years at the time of their birth (e.g. the mean difference in test score in the offspring of fathers aged 40 to 44 years were -0.03 [95% CI (-0.27 to 0.20)] compared with fathers aged 25 to 29 years). Conclusions We did not find that the offspring of older fathers had impaired cognitive ability as young adults. Whereas, we found a tendency that the offspring of teen fathers have lower cognitive ability. Thus, our results suggest that any potentially deleterious effects of older fathers on general cognitive ability as young adults may be counter-balanced by other potentially beneficial factors.
Imagined vs. Actual "Others": An Experiment on Interethnic Giving Afghanistan

Does willingness to aid "others" change when in their physical presence? We argue that studies cueing non-coethnics through names and photos may underestimate discrimination resulting from actual interethnic interaction. In an experiment in Kabul, Afghanistan, Dari-speaking day-laborers contribute their earnings to a hospital under one of three randomly-assigned experimental conditions. In In-group, the hospital is in a Dari-speaking province; in Out-group-Abstract and Out-group-Real, it is in a Pashto-speaking (Pashtun) province. While subjects in In-group and Outgroup- Abstract wait for the experiment with only Dari-speakers present, subjects in Out-group-Real wait among both Dari-speakers and Pashto-speakers. When Pashtuns are absent, the findings accord with other experiments that find little to no out-group discrimination. However, the physical presence of Pashtuns (Out-group-Real) decreases contributions by 25%. Consistent with the threat hypothesis, contributions decrease the longer Dari-speakers wait with Pashtuns, though subjects' youth and ability to speak Pashto mediate this effect.
Transient Network at Large Deformations: Elastic–Plastic Transition and Necking Instability

We theoretically investigate the mechanical response of a transient network, which is characterised by dynamically breaking and re-forming crosslinks, and accounts for the finite chain extensibility (thus permitting the large deformations to be described). We build the general theory that incorporates the widely accepted empirical model of hyper-elasticity at large deformations (the Gent model) and naturally includes the microscopic behavior of transient crosslinks under the local tension applied to them. The full analytical expression for the elastic energy, or equivalently, the constitutive relation for arbitrary deformation is derived, and then the example of uniaxial tensile strain is focused on. In this case, we show that the mechanical response depends on the ratio of the imposed strain rate and the breakage rate of the crosslink: the system flows plastically (over a yield point) when the strain rate is much smaller than the breakage rate, while it remains elastic when the strain rate is much larger than the breakage rate. There is a broad range of this transition when the elastic and plastic regions of the sample coexist, and a resulting necking instability occurs. As a generalisation, we also consider a dual transient network, with two components penetrating each other, each having its own microscopic crosslink dynamics. The two networks add their local forces and share the deformation; we find that the network with a lower breakage rate determines the global deformation of the system.
Failed disc winds: a physical origin for the soft X-ray excess?

The origin of the soft X-ray excess emission observed in many type-1 active galactic nuclei (AGN) has been an unresolved problem in X-ray astronomy for over two decades. We develop the model proposed by Gierlinski & Done, which models the soft excess with heavily smeared, ionized, absorption, by including the emission that must be associated with this absorption. We show that, rather than hindering the ionized absorption model, the addition of the emission actually helps this model reproduce the soft excess. The emission fills in some of the absorption trough, while preserving the sharp rise at ∼1 keV, allowing the total model to reproduce the soft excess curvature from a considerably wider range of model parameters. We demonstrate that this model is capable of reproducing even the strongest soft X-ray excesses by fitting it to the XMM-Newton EPIC PN spectrum of PG 1211+143, with good results. The addition of the emission reduces the column density required to fit these data by a factor of ∼2 and reduces the smearing velocity from ∼0.28c to ∼0.2c. Gierlinski & Done suggested a tentative origin for the absorption in the innermost, accelerating, region of an accretion disc wind, and we highlight the advantages of this interpretation in comparison to accretion disc reflection models of the soft excess. Associating this material with a wind off the accretion disc results in several separate problems however, namely, the radial nature, and the massive implied mass-loss rate, of the wind. We propose an origin in a 'failed wind', where the central X-ray source is strong enough to overionize the wind, removing the acceleration through line absorption before the material reaches escape velocity, allowing the material to fall back to the disc at larger radii.
Consumer Innovativeness and Loyalty to Non-GMO Foods: The Role of Cognitive and Affective Beliefs

ABSTRACT Public concern over genetically modified (GMO) foods has led marketers to promote non-GMO branded foods to consumers. However, factors affecting consumers’ loyalty to non-GMO branded foods are still largely unknown. Building on the product diffusion model, the present research predicts and finds that consumer innovativeness has a positive effect on consumer loyalty to non-GMO foods. In addition, the present research draws from previous research on attitude formation and tests whether cognitive and/or affective beliefs may mediate the relationship between consumer innovativeness and loyalty to non-GMO foods. The results of a parallel multiple mediation model suggest that cognitive, but not affective, beliefs fully mediate the effect of consumer innovativeness on loyalty to non-GMO foods. These results have direct implications for marketers of non-GMO foods and, in general, increase our understanding of the process by which consumer innovativeness may affect consumer loyalty.
What prevents outgassing of methane to the atmosphere in Lake Tanganyika

[1] Tropical East African Lake Tanganyika hosts the Earth’s largest anoxic freshwater body. The entire water column holds over 23 Tg of the potent greenhouse gas methane (CH4). Methane is formed under sulphate poor conditions via carbon dioxide reduction or fermentation from detritus and relict sediment organic matter. Permanent density stratification supports an accumulation of CH4 below the permanent oxycline. Despite CH4 significance for global climate, anaerobic microbial consumption of CH4 in freshwater is poorly understood. Here we provide evidence for intense methanotrophic activity not only in the oxic but also in the anoxic part of the water column of Lake Tanganyika. We measured CH4, 13 C of dissolved CH4, dissolved oxygen (O2), sulphate (SO4− ), sulphide (HS − ) and the transient tracers chlorofluorocarbon 12 (CFC 12) and tritium ( 3 H). A basic one dimensional model, which considers vertical transport and biogeochemical fluxes and transformations, was used to interpret the vertical distribution of these substances. The results suggest that the anaerobic oxidation of CH4 is an important mechanism limiting CH4 to the anoxic zone of Lake Tanganyika. The important role of the anaerobic oxidation for CH4 concentrations is further supported by high abundances (up to ∼33% of total DAPI stained cells) of single living archaea, identified by fluorescence in situ hybridization.
Increased extracellular deposition of fibrillin-containing fibrils in pseudoexfoliation syndrome.

PURPOSE To localize the distribution of fibrillin-containing microfibrils in normal human anterior segment tissues and to characterize the role of fibrillin in the pathogenesis of pseudoexfoliation syndrome. METHODS Anterior segment tissues were obtained from 10 eyes with pseudoexfoliation syndrome and 10 normal eyes and investigated by indirect immunofluorescence and electron microscopic immunogold labeling using a monoclonal antibody to fibrillin-1. RESULTS In addition to labeling of zonular fibers, fibrillin-immunoreactive microfibrillar bundles generally were found in the corneal stroma; the stromal connective tissues of conjunctiva, ciliary body, and iris, especially in the iris root area; the periphery of Schlemm's canal, the scleral spur, and the most anterior portion of the trabecular meshwork; the ciliary muscle, and the dilator and sphincter muscles of the iris; the basement membranes of peripheral corneal epithelium, conjunctival epithelium, ciliary pigmented epithelium, and the lens capsule. The microfibrillar bundles were found to be isolated or in association with elastic fibers and cellular basement membranes. In pseudoexfoliation eyes, an additional strong immunoreaction was localized to pseudoexfoliation fibers and their microfibrillar subunits in close proximity to surfaces of cells involved in pseudoexfoliation fiber production. CONCLUSIONS The fibrillin-containing microfibrillar system in normal ocular tissues is suggested to have a substantial role in the maintenance of tissue integrity by providing tensile strength and flexibility to mechanically strained tissues. The findings further provide evidence for fibrillin as an intrinsic component of pseudoexfoliation fibers, suggesting the possibility that enhanced expression of fibrillin or abnormal aggregation of fibrillin-containing microfibrils may be involved in the pathogenesis of pseudoexfoliation syndrome.
Video games: A significant cognitive artifact of contemporary youth culture

Video games are not just an important cultural artifact of youth culture but have considerable cognitive worth. Centered within an information processing theory and mediating processes' framework, the empirical qualitative study investigated, via stimulated recall methods, the thinking skills and strategies of five teenagers while playing an action-adventure video game. Sixteen types and 600 instances of cognitive skills and 11 types and 155 instances of cognitive strategies were identified. The thinking skills included high engagement with school valued cognitive skills, such as metacognition, and deduction and induction strategies. The findings support the informal educative value of playing recreation video games and their inclusion in schools.
Design and Implementation of Model Predictive Control for Electrical Motor Drives

This paper deals with a model predictive control (MPC) algorithm applied to electrical drives. The main contribution is a comprehensive and detailed description of the controller design process that points out the most critical aspects and also gives some practical hints for implementation. As an example, the MPC is developed for a permanent-magnet synchronous motor drive. Speed and current controllers are combined together, including all of the state variables of the system, instead of keeping the conventional cascade structure. In this way, the controller enforces both the current and the voltage limits. Both simulation and experimental results point out the validity of the design procedure and the potentials of the MPC in the electrical drive field.
The Role of Thriving and Training in Merger Success: An Integrative Learning Perspective

Abstract This empirical investigation studies the correlates and predictors of employees’ psychological outcomes during mergers and acquisitions (M&As) in the context of India. This study examined the role of different types of training initiatives (awareness training, human capital development training, and cross-cultural training) on building employees feeling of psychological empowerment and thriving. Further, second-order attitudes were studied in the form of employee satisfaction and commitment. A cross-sectional research design was adopted where quantitative and qualitative data were collected to investigate the interplay between the variables. Data were collected on an adapted standardized questionnaire from the employees of a public sector organization (N = 117) which had merged with a software company to deliver its IT services. Descriptive analysis, multiple correlational analysis, and stepwise regression analysis have assisted in exploring the different relationships amongst the variables. This study produces a prescriptive framework for merger success based on the model of growth and thriving (Spreitzer & Porath, 2012). Broadly, the results point towards the facilitative role of training in developing feelings of psychological empowerment, thriving, commitment and satisfaction with the merger, however qualitative data identified significant cultural undercurrents.