Miracle-dz/UniFAR-FTUs huggingface dataset:
Subthalamic Stimulation-Induced Forelimb Dyskinesias Are Linked to an Increase in Glutamate Levels in the Substantia Nigra Pars Reticulata

The neurobiological mechanisms by which high-frequency stimulation of the subthalamic nucleus (STN–HFS) alleviates the motor symptoms of Parkinson's disease (PD) remain unclear. In this study, we analyzed the effects of STN–HFS on motor behavior in intact or hemiparkinsonian rats (6-hydroxydopamine lesion of the substantia nigra pars compacta) and investigated the correlation between these effects and extracellular glutamate (Glu) and GABA levels, assessed by intracerebral microdialysis in the substantia nigra pars reticulata (SNr). STN–HFS at an intensity corresponding to the threshold inducing contralateral forelimb dyskinesia, increased Glu levels in the SNr of both intact and hemiparkinsonian rats. In contrast, STN–HFS at half this intensity did not affect Glu levels in the SNr in intact or hemiparkinsonian rats but increased GABA levels in hemiparkinsonian rats only. STN–HFS-induced forelimb dyskinesia was blocked by microinjection of the Glu receptor antagonist kynurenate into the SNr and facilitated by microinjection of a mixture of the Glu receptor agonists AMPA and NMDA into the SNr. These new neurochemical data suggest that STN–HFS-induced forelimb dyskinesia is mediated by glutamate, probably via the direct activation of STN axons, shedding light on the mechanisms of STN–HFS in PD.
Measuring the impact of musical learning on cognitive, behavioural and socio-emotional wellbeing development in children

This study investigated the effects of musical instrument learning on the concomitant development of cognitive, behavioural and socio-emotional skills in 38 seven- to nine-year-old children. Pre- and post-test measures of intelligence, memory, socio-emotional behaviour, motor ability and visual-motor integration were compared in children who received either extra-curricular musical training (EMT: n = 19) or statutory school music group lessons (SSM: n = 19). Results showed a significant association between musical aptitude and intelligence overall. The EMT group showed a significant increase in IQ (7 points), in comparison to 4.3 points for the SSM group, suggesting an effect of musical learning on intelligence. No effects were found for memory, or for visual motor integration or socio-emotional behaviour. However, significant improvements in gross motor ability where revealed for the EMT group only, for the aiming and catching composite. With regard to the measure of fluid intelligence, these findings support previous studies. The novel use of the Movement Assessment Battery for Children provides evidence that musical learning may support development in a child’s ability to judge distance, consider velocity, focus and use their proprioceptive, interoceptive and exteroceptive nervous systems.
On the importance of parallel application placement in NUMA multiprocessors

The thesis of this paper is that scheduling decisions in large-scale, shared-memory, NUMA (Non-Uniform Memory Access) multiprocessors must consider not only how many processors, but also which processors to allocate to each application. We call the problem of assigning parallel processes of an application to processors application placement. We explore the importance of placement decisions by measuring the execution time of several parallel applications using different placements on a shared-memory NUMA multiprocessor. The results of these experiments lead us to conclude that, as expected, in small-scale mildly NUMA multiprocessors, placement decisions have only a minor affect on the execution time of parallel applications. However, the results also show that placement decisions in large-scale multiprocessors are critical and localization that considers the architectural clusters inherent in these systems is essential. Our experiments also show that the importance of placement decisions increases substantially with the size and NUMAness of the system and that the placement of individual processes of an application within the subset of chosen processors also significantly impacts performance.
Diasporic homecomings to the Kurdistan region of Iraq: Pre- and post-return experiences shaping motivations to re-return

This article examines the dynamics of voluntary return migration to the Kurdistan region of Iraq in the post-Saddam period and provides a contextualised analysis of the returnees’ experiences in a rapidly shifting geopolitical situation in Kurdistan. It specifically focuses on examining how diasporans’ motivations to return, as well as their plans to re-return, are shaped in relation to their experiences in host societies and in the ‘homeland’. Drawing from qualitative interviews, it shows that Kurdish diasporans’ return can be characterised as ‘diasporic homecoming’ as it is motivated by the desire to contribute to the economic and political development of the Kurdistan region of Iraq. However, the mismatch between expectations and ‘homeland’ realities combined with positive experiences and social capital accumulated in the host country makes plans for re-return more foreseeable and less risky.
Adolescents' and mothers' conflict management constellations: Links with individual and relational functioning

In the present multi-informant study, we examined dyadic combinations of adolescent and maternal conflict management styles through stepwise latent class analysis. We investigated how these dyadic conflict classes related to adolescents' and mothers' perceptions of individual and relational functioning (depressive symptoms, self-esteem, conflict frequency, relationship satisfaction, parenting), both concurrently and over time. Four conflict styles were investigated: positive problem solving, withdrawal, conflict engagement, and compliance. Questionnaires were completed by 526 adolescents and mothers. Findings pointed to four meaningful conflict management constellations: Dyadic Positive Management, Unbalanced Management, Adolescent Negative Management and Dyadic Negative Management. These constellations were differentially related to individual and relational factors. This study emphasized the importance of a typological dyadic approach in examining conflict management.
The Lyman-α Forest Power Spectrum from the Sloan Digital Sky Survey

We measure the power spectrum, PF (k, z), of the transmitted flux in the Lyα forest using 3035 high redshift quasar spectra from the Sloan Digital Sky Survey. This sample is almost two orders of magnitude larger than any previously available data set, yielding statistical errors of ∼ 0.6% and ∼ 0.005 on, respectively, the overall amplitude and logarithmic slope of PF (k, z). This unprecedented statistical power requires a correspondingly careful analysis of the data and of possible systematic contaminations in it. For this purpose we reanalyze the raw spectra to make use of information not preserved by the standard pipeline. We investigate the details of the noise in the data, resolution of the spectrograph, sky subtraction, quasar continuum, and metal absorption. We find that background sources such as metals contribute significantly to the total power and have to be subtracted properly. We also find clear evidence for SiIII correlations with the Lyα forest and suggest a simple model to account for this contribution to the power. While it is likely that our newly developed analysis technique does not eliminate all systematic errors in the PF (k, z) measurement below the level of the statistical errors, our tests indicate that any residual systematics in the analysis are unlikely to affect the inference of cosmological parameters from PF (k, z). These results should provide an essential ingredient for all future attempts to constrain modeling of structure formation, cosmological parameters, and theories for the origin of primordial fluctuations. Physics Department, Princeton University, Princeton, NJ 08544, USA; pm,useljak@princeton.edu Physics Department, MIT, 77 Massachusetts Av. , Cambridge MA 02139, USA Princeton University Observatory, Princeton, NJ 08544, USA Department of Astronomy, Ohio State University, Columbus, OH 43210, USA School of Natural Sciences, Institute for Advanced Study, Einstein Drive, Princeton NJ 08540, USA Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802,
On the automorphism group of generalized Baumslag–Solitar groups

A generalized Baumslag-Solitar group (GBS group) is a finitely generated group $G$ which acts on a tree with all edge and vertex stabilizers infinite cyclic. We show that Out(G) either contains non-abelian free groups or is virtually nilpotent of class at most 2. It has torsion only at finitely many primes. One may decide algorithmically whether Out(G) is virtually nilpotent or not. If it is, one may decide whether it is virtually abelian, or finitely generated. The isomorphism problem is solvable among GBS groups with Out(G) virtually nilpotent. If $G$ is unimodular (virtually $F_n \times Z$), then Out(G) is commensurable with a semi-direct product $Z^k \rtimes Out(H)$ with $H$ virtually free.
Regulated expression of telomerase activity in human T lymphocyte development and activation

Telomerase, a ribonucleoprotein that is capable of synthesizing telomeric repeats, is expressed in germline and malignant cells, and is absent in most normal human somatic cells. The selective expression of telomerase has thus been proposed to be a basis for the immortality of the germline and of malignant cells. In the present study, telomerase activity was analyzed in normal human T lymphocytes. It was found that telomerase is expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T lymphocytes, and at a low to undetectable level in peripheral blood T lymphocytes. Moreover, telomerase activity is highly inducible in peripheral T lymphocytes by activation through CD3 with or without CD28 costimulation, or by stimulation with phorbol myristate acetate (PMA)/ionomycin. The induction of telomerase by anti-CD3 plus anti-CD28 (anti-CD3/CD28) stimulation required RNA and protein synthesis, and was blocked by herbimycin A, an inhibitor of S pi protein tyrosine kinases. The immunosuppressive drug cyclosporin A selectively inhibited telomerase induction by PMA/ionomycin and by anti-CD3, but not by anti-CD3/CD28. Although telomerase activity in peripheral T lymphocytes was activation dependent and correlated with cell proliferation, it was not cell cycle phase restricted. These results indicate that the expression of telomerase in normal human T lymphocytes is both developmentally regulated and activation induced. Telomerase may thus play a permissive role in T cell development and in determining the capacity of lymphoid cells for cell division and clonal expansion.
Enhancing curricula and learning environments using critical realist perspectives and approaches: a case study and critique

ABSTRACT While critical realist (CR) ontological and epistemological perspectives and research approaches are becoming more widely adopted by higher education researchers, the scope of research is relatively limited, and novice researchers in the area still struggle to create rich, in-depth, and critical accounts of these approaches ‘in action’. This article provides an account of teacher-researchers’ exploration of these perspectives in the context of an important aspect their everyday teaching practice – the design of effective curricula and learning environments. The context is research that focused on the design, evaluation, and enhancement of learning environments intended to facilitate students’ development of design thinking expertise. The article outlines the researchers’ CR paradigm positioning and implications for methodologies used to gather, analyse, and theorise data about the response of design and business students to three iterations of a design thinking learning environment. The research involved action research that integrated survey, case study, and theorising methodologies. Examples of data, analyses, and explanatory theory are provided to give insights into specific research tasks and their outcomes. Possible explanations for the findings and their implications for attempts to enhance the learning environment are considered from a CR perspective along with challenges that deploying these approaches may entail.
Diversity in Functional Organization of Class I and Class II Biotin Protein Ligase

The cell envelope of Mycobacterium tuberculosis (M.tuberculosis) is composed of a variety of lipids including mycolic acids, sulpholipids, lipoarabinomannans, etc., which impart rigidity crucial for its survival and pathogenesis. Acyl CoA carboxylase (ACC) provides malonyl-CoA and methylmalonyl-CoA, committed precursors for fatty acid and essential for mycolic acid synthesis respectively. Biotin Protein Ligase (BPL/BirA) activates apo-biotin carboxyl carrier protein (BCCP) by biotinylating it to an active holo-BCCP. A minimal peptide (Schatz), an efficient substrate for Escherichia coli BirA, failed to serve as substrate for M. tuberculosis Biotin Protein Ligase (MtBPL). MtBPL specifically biotinylates homologous BCCP domain, MtBCCP87, but not EcBCCP87. This is a unique feature of MtBPL as EcBirA lacks such a stringent substrate specificity. This feature is also reflected in the lack of self/promiscuous biotinylation by MtBPL. The N-terminus/HTH domain of EcBirA has the self-biotinable lysine residue that is inhibited in the presence of Schatz peptide, a peptide designed to act as a universal acceptor for EcBirA. This suggests that when biotin is limiting, EcBirA preferentially catalyzes, biotinylation of BCCP over self-biotinylation. R118G mutant of EcBirA showed enhanced self and promiscuous biotinylation but its homologue, R69A MtBPL did not exhibit these properties. The catalytic domain of MtBPL was characterized further by limited proteolysis. Holo-MtBPL is protected from proteolysis by biotinyl-5′ AMP, an intermediate of MtBPL catalyzed reaction. In contrast, apo-MtBPL is completely digested by trypsin within 20 min of co-incubation. Substrate selectivity and inability to promote self biotinylation are exquisite features of MtBPL and are a consequence of the unique molecular mechanism of an enzyme adapted for the high turnover of fatty acid biosynthesis.
Restricted and Repetitive Behaviour in Persons with Autism (Ages 0-18): An Integrative Review of Treatment Related to Occupational Therapy

Objective : To identify evidence-based behavioural interventions used to decrease restricted and repetitive behaviour (RRB) in children with autism (ages 0-18); to understand the application of these strategies within the PEO (Person, Environment, Occupation) Model of Occupational Performance and the role of the occupational therapist in addressing this limitation. Background : RRB is a core feature of autism that often impedes functional behaviour. Decreasing RRB to enable functional behaviours is central to the occupational therapistâ€™s role with this population. Many interventions identified as effective for this impairment are based on the principles of applied behaviour analysis (ABA). Method : An integrative review of the literature was completed to identify interventions targeting RRBs. Those found to be effective are described within an ABA framework and within the PEO Model of Occupational Performance. Â Results : This review identified Â twenty-eight effective interventions used to treat RRBs in autism relevant to the field of occupational therapy. Categorization of interventions using an ABA framework and the PEO Model allowed comparison between approaches and application to occupational therapy practice. Conclusion : A functional behaviour approach (FBA) used in combination with the PEO model will enable greater understanding of RRBs and provide a more comprehensive approach to the treatment of RRBs in children with autism.
Cloning and analysis of the pepV dipeptidase gene of Lactococcus lactis MG1363

The gene pepV, encoding a dipeptidase from Lactococcus lactis subsp. cremoris MG1363, was identified in a genomic library in pUC19 in a peptidase-deficient Escherichia coli strain and subsequently sequenced. PepV of L. lactis is enzymatically active in E. coli and hydrolyzes a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides. Northern (RNA) and primer extension analyses indicate that pepV is a monocistronic transcriptional unit starting 24 bases upstream of the AUG translational start codon. The dipeptidase of L. lactis was shown to be similar to the dipeptidase encoded by pepV of L. delbrueckii subsp. lactis, with 46% identity in the deduced amino acid sequences. A PepV-negative mutant of L. lactis was constructed by single-crossover recombination. Growth of the mutant strain in milk was significantly slower than that of the wild type, but the strains ultimately reached the same final cell densities.
Temporal Variation of SOC Enrichment from Interrill Erosion over Prolonged Rainfall Simulations

Sediment generated by interrill erosion is commonly assumed to be enriched in soil organic carbon (SOC) compared to the source soil. However, the reported SOC enrichment ratios (ER SOC ) vary widely. It is also noteworthy that most studies reported that the ER SOC is greater than unity, while conservation of mass dictates that the ER SOC of sediment must be balanced over time by a decline of SOC in the source area material. Although the effects of crusting on SOC erosion have been recognized, a systematic study on complete crust formation and interrill SOC erosion has not been conducted so far. The aim of this study was to analyze the effect of prolonged crust formation and its variability on the ER SOC of sediment. Two silty loams were simultaneously exposed to a rainfall simulation for 6 h. The ER SOC in sediment from both soils increased at first, peaked around the point when steady-state runoff was achieved and declined afterwards. The results show that crusting plays a crucial role in the ER SOC development over time and, in particular, that the conservation of mass applies to the ER SOC of sediment as a consequence of crusting. A “constant” ER SOC of sediment is therefore possibly biased, leading to an overestimation of SOC erosion. The results illustrate that the potential off-site effects of selective interrill erosion require considering the crusting effects on sediment properties in the specific context of the interaction between soil management, rainfall and erosion.
Neuromodulatory Approaches for Chronic Pain Management: Research Findings and Clinical Implications

ABSTRACT Two lines of evidence provide preliminary support for the role that brain state, measured via electroencephalogram (EEG), may play in chronic pain. First, research has identified a link between brain EEG activity and the experience of pain. Second, there are a number of published studies documenting the beneficial effects of interventions that impact the cortical activity associated with chronic pain. These interventions include neurobehavioral treatments such as neurofeedback and hypnosis as well as invasive and non-invasive brain stimulation. Preliminary data showing the efficacy of neuromodulatory strategies for treating pain provides compelling reason to examine how cortical activity (as measured by EEG) may underlie the experience of pain. Existing data already suggest specific approaches that neurofeedback clinicians might consider when treating patients with chronic pain. Reciprocally, observations by neurofeedback practitioners could provide important case data that could foster the desig.
Absolute Priority Rule Violations, Credit Rationing, and Efficiency

Violations of the absolute priority rule (APR) are commonplace in private workouts, formal business reorganizations, and personal bankruptcies. While some theorists suggest they may arise endogenously, they are clearly magnified by the institutional structure of the bankruptcy code. This paper shows that APR violations exacerbate credit rationing problems by reducing the payment lenders receive in default states. Furthermore, APR violations make default more likely to occur, thereby making debt financing more costly. Together, these results support the view that APR violations create an impediment to efficient financial contracting.
A New Approach for an Artificial Evolving System

We have built an adaptive system (AS) that is able to evolve and improve its answering ability to all reiterative questions from an artificial environment. Indeed, we have created a basic artificial system that is able to do what is usually understood as a natural system's behavior. In this work, rather than using logic, we encourage coherence, because it is not logic correctness but harmony between the system and its environment the primary goal of our work. As a central part of the system, we have designed and implemented an Existential Machine and experimental results show that evolution is feasible for restricted environments. In this article, the core idea supporting the system is shown, a rapid view over the existential machine is presented, and a set of results pointing to future applications is discussed.
IglG and IglI of the Francisella Pathogenicity Island Are Important Virulence Determinants of Francisella tularensis LVS

ABSTRACT The Gram-negative bacterium Francisella tularensis is the causative agent of tularemia, a disease intimately associated with the multiplication of the bacterium within host macrophages. This in turn requires the expression of Francisella pathogenicity island (FPI) genes, believed to encode a type VI secretion system. While the exact functions of many of the components have yet to be revealed, some have been found to contribute to the ability of Francisella to cause systemic infection in mice as well as to prevent phagolysosomal fusion and facilitate escape into the host cytosol. Upon reaching this compartment, the bacterium rapidly multiplies, inhibits activation of the inflammasome, and ultimately causes apoptosis of the host cell. In this study, we analyzed the contribution of the FPI-encoded proteins IglG, IglI, and PdpE to the aforementioned processes in F. tularensis LVS. The ΔpdpE mutant behaved similarly to the parental strain in all investigated assays. In contrast, ΔiglG and ΔiglI mutants, although they were efficiently replicating in J774A.1 cells, both exhibited delayed phagosomal escape, conferred a delayed activation of the inflammasome, and exhibited reduced cytopathogenicity as well as marked attenuation in the mouse model. Thus, IglG and IglI play key roles for modulation of the intracellular host response and also for the virulence of F. tularensis.
Assessing environmental impacts on stream water quality: the use of cumulative flux and cumulative flux difference approaches to deforestation of the Hafren Forest, mid-Wales

Abstract. A method for examining the impacts of disturbance on stream water quality based on paired catchment "control" and "response" water quality time series is described in relation to diagrams of cumulative flux and cumulative flux difference. The paper describes the equations used and illustrates the patterns expected for idealised flux changes followed by an application to stream water quality data for a spruce forested catchment, the Hore, subjected to clear fell. The water quality determinands examined are sodium, chloride, nitrate, calcium and acid neutralisation capacity. The anticipated effects of felling are shown in relation to reduction in mist capture and nitrate release with felling as well as to the influence of weathering and cation exchange mechanisms, but in a much clearer way than observed previously using other approaches. Keywords: Plynlimon, stream, Hore, acid neutralisation capacity, calcium, chloride, nitrate, sodium, cumulative flux, flux