Miracle-dz/UniFAR-FTUs huggingface dataset:
Description of a Prospective 17DD Yellow Fever Vaccine Cohort in Recife, Brazil

From September 2005 to March 2007, 238 individuals being vaccinated for the first time with the yellow fever (YF) -17DD vaccine were enrolled in a cohort established in Recife, Brazil. A prospective study indicated that, after immunization, anti-YF immunoglobulin M (IgM) and anti-YF IgG were present in 70.6% (IgM) and 98.3% (IgG) of the vaccinated subjects. All vaccinees developed protective immunity, which was detected by the plaque reduction neutralization test (PRNT) with a geometric mean titer of 892. Of the 238 individuals, 86.6% had IgG antibodies to dengue virus; however, the presence of anti-dengue IgG did not interfere significantly with the development of anti-YF neutralizing antibodies. In a separate retrospective study of individuals immunized with the 17DD vaccine, the PRNT values at 5 and 10 years post-vaccination remained positive but showed a significant decrease in neutralization titer (25% with PRNT titers < 100 after 5 years and 35% after 10 years).
Exploring the Role of Language Development and Verbal Encoding in Short-Term Recognition Memory in Early Childhood

Memory Tasks 34 3. Multiple Regression Analysis: Language, Gender, and EEG Coherence (Retrieval) as Predictors of Performance on Picture Memory Task 35
' s personal copy Making decisions through a distributed consensus

Introduction Great progress has recently been made toward understanding the neural mechanisms of decision-making [1,2,3 ,4 ,5 ,6,7 ,8 ,9,10]. However, despite many reports showing how neural activity in different brain regions correlates with expected rewards, action values, and other relevant variables, there is still no agreement about the functional architecture that underlies decisionmaking. We have substantial data on the elements of the system, but are only beginning to glimpse its shape. Here, I focus on just one outstanding question: do we make decisions among abstract representations of outcomes, a sensorimotor space of actions, or through a distributed consensus across many levels?
Identiﬁcation and Characterization of a Novel CprA Reductive Dehalogenase Speciﬁc to Highly Chlorinated Phenols from Desulﬁtobacterium hafniense Strain PCP-1 (cid:1)

Desulﬁtobacterium hafniense strain PCP-1 reductively dechlorinates pentachlorophenol (PCP) to 3-chloro-phenol and a variety of halogenated aromatic compounds at the ortho , meta , and para positions. Several reductive dehalogenases (RDases) are thought to be involved in this cascade of dehalogenation. We partially puriﬁed a novel RDase involved in the dechlorination of highly chlorinated phenols from strain PCP-1 cultivated in the presence of 2,4,6-trichlorophenol. The RDase was membrane associated, and the activity was sensitive to oxygen, with a half-life of 128 min upon exposure to air. The pH and temperature optima were 7.0 and 55°C, respectively. Several highly chlorinated phenols were dechlorinated at the ortho positions. The highest dechlorinating activity levels were observed with PCP, 2,3,4,5-tetrachlorophenol, and 2,3,4-trichloro- phenol. 3-Chloro-4-hydroxyphenylacetate, 3-chloro-4-hydroxybenzoate, dichlorophenols, and monochlorophe-nols were not dechlorinated. The apparent K m value for PCP was 46.7 (cid:1) M at a methyl viologen concentration of 2 mM. A mixture of iodopropane and titanium citrate caused a light-reversible inhibition of the dechlorinating activity, suggesting the involvement of a corrinoid cofactor. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the partially puriﬁed preparation revealed 2 bands with apparent molecular masses of 42 and 47 kDa. Mass spectrometry analysis using Mascot to search the genome sequence of D. hafniense strain DCB-2 identiﬁed the 42-kDa band as NADH-quinone oxidoreductase, subunit D, and the 47-kDa band as the putative chlorophenol RDase CprA3. This is the ﬁrst report of an RDase with high afﬁnity and high dechlorinating activity toward PCP.
Efficacy of Biosolids in Assisted Phytostabilization of Metalliferous Acidic Sandy Soils with Five Grass Species

The role of sewage sludge as an immobilising agent in the phytostabilization of metal-contaminated soil was evaluated using five grass species viz., Dactylis glomerata L. , Festuca arundinacea Schreb. , F. rubra L. , Lolium perenne L. , L. westerwoldicum L. The function of metal immobilization was investigated by monitoring pH, Eh and Cd, Pb, and Zn levels in column experiment over a period of 5-months. Grasses grown on sewage sludge-amendments produced high biomass in comparison to controls. A significant reduction in metal uptake by plants was also observed as a result of sewage sludge application, which was attributed to decreased bioavailability through soil stabilisation. We have observed that the sludge amendment decreased metal bioavailability and concentrations in soil at a depth of 25 cm, in contrast to untreated columns, where metal concentrations in the soil solution were very high.
Can boredom help? Increased prosocial intentions in response to boredom

Abstract Boredom is typically regarded a nuisance. Past research on boredom depicts this common emotion as a correlate of many detrimental psychological and social factors, including addiction, depression, discrimination, and aggression. We present a more nuanced perspective on boredom. Specifically, we propose and test that state boredom serves an important self-regulatory function with the potential to foster positive interpersonal consequences: It signals a lack of purpose in activity and fosters a search for meaningful engagement. We examined whether boredom can subsequently cause prosocial intentions if the corresponding prosocial behavior is seen as purposeful. As predicted, boredom, which is characterized by a search for meaning (pilot study), promoted prosocial intentions (Experiment 1), in particular when the corresponding behavior was seen as highly meaningful (Experiment 2). Our novel findings suggest that boredom can have desirable consequences and recasts this emotion as not merely good or bad but rather as personally and socially functional.
vTPM: Virtualizing the Trusted Platform Module

We present the design and implementation of a system that enables trusted computing for an unlimited number of virtual machines on a single hardware platform. To this end, we virtualized the Trusted Platform Module (TPM). As a result, the TPM's secure storage and cryptographic functions are available to operating systems and applications running in virtual machines. Our new facility supports higher-level services for establishing trust in virtualized environments, for example remote attestation of software integrity. We implemented the full TPM specification in software and added functions to create and destroy virtual TPM instances. We integrated our software TPM into a hypervisor environment to make TPM functions available to virtual machines. Our virtual TPM supports suspend and resume operations, as well as migration of a virtual TPM instance with its respective virtual machine across platforms. We present four designs for certificate chains to link the virtual TPM to a hardware TPM, with security vs. efficiency trade-offs based on threat models. Finally, we demonstrate a working system by layering an existing integrity measurement application on top of our virtual TPM facility.
Algorithms for Itinerary Planning in Multimodal Transportation Networks

The itinerary planning problem in an urban public transport system constitutes a common routing and scheduling decision faced by travelers. The objective of this paper is to present a new formulation and an algorithm for solving the itinerary planning problem, i.e., determination of the itinerary that lexicographically optimizes a set of criteria (i.e., total travel time, number of transfers, and total walking and waiting time) while departing from the origin and arriving at the destination within specified time windows. Based on the proposed formulation, the itinerary planning problem is expressed as a shortest path problem in a multimodal time-schedule network with time windows and time-dependent travel times. A dynamic programming-based algorithm has been developed for the solution of the emerging problem. The special case of the problem involving a mandatory visit at an intermediate stop within a given time window is formulated as two nested itinerary planning problems which are solved by the aforementioned algorithm. The proposed algorithm has been integrated in a Web-based journey planning system, whereas its performance has been assessed by solving real-life itinerary planning problems defined on the Athens urban public transport network, providing fast and accurate solutions.
Emotional Intelligence and Venture Performance

Scholars emphasize the importance of emotion in entrepreneurship and the potential of emotional intelligence, but research is sparse in the field. We develop and test a novel partial mediation model of emotional intelligence, interpersonal processes, and venture performance. The results indicate that interpersonal emotional skills, which entail the recognition and management of emotions in others, has a direct effect on venture performance, but intrapersonal emotional skills pertaining to self‐awareness and regulation of emotions do not. Additionally, both the intrapersonal and interpersonal dimensions of emotional intelligence have an indirect influence on firm performance via interpersonal processes that entail functioning in key activities within the firm. We discuss the implications and address potential avenues for future research on this important topic.
Visual performance after conventional LASIK and wavefront-guided LASIK with iris-registration: results at 1 year.

AIM To compare visual performance of wavefront-guided laser in situ keratomileusis (LASIK) with iris-registration (Wg-LASIK group) and conventional LASIK (LASIK group) one year after surgery and analyze the correlation between wavefront aberrations and visual performance. METHODS Eight hundred and fifty-two myopic eyes of 430 patients were enrolled in this prospective study and divided into two groups: Wg-LASIK group (436 eyes) and LASIK group (416 eyes). A Wavescan Wavefront aberrometer was used to analyze Zernike coefficients and the root-mean-square (RMS) of higher order aberrations, and Optec 6500 visual function instrument was used to measure contrast sensitivity (CS) before and 3, 6, 12 months after surgery. RESULTS The mean spherical equivalent (SE) in Wg-LASIK group was significantly better than those in LASIK group one year after surgery (P=0.024). Wg-LASIK eyes showed better CS values than LASIK eyes at all spatial frequencies with and without glare after surgery (P all<0.01). Moreover, the increase of higher RMS (RMSh), coma, RMS3, RMS4, RMS5 in Wg-LASIK group were significantly lower than those in LASIK group 1 year after surgery (P all<0.05). The increase of coma, spherical aberration (SA), RMS3 and RMS4 in Wg-LASIK and coma and RMS3 in LASIK group were negatively correlated with reduction of contrast sensitivity 1 year after surgery. CONCLUSION A significant better visual performance is got in Wg-LASIK group compared with LASIK group 1 year after surgery, and the Wg-LASIK is particularly suitable for eyes with high-magnitude RMSh.
Maximizing quantitative traits in the mating design problem via simulation-based Pareto estimation

ABSTRACT Commercial plant breeders improve economically important traits by selectively mating individuals from a given breeding population. Potential pairings are evaluated before the growing season using Monte Carlo simulation, and a mating design is created to allocate a fixed breeding budget across the parent pairs to achieve desired population outcomes. We introduce a novel objective function for this mating design problem that accurately models the goals of a certain class of breeding experiments. The resulting mating design problem is a computationally burdensome simulation optimization problem on a combinatorially large set of feasible points. We propose a two-step solution to this problem: (i) simulate to estimate the performance of each parent pair and (ii) solve an estimated version of the mating design problem, which is an integer program, using the simulation output. To reduce the computational burden when implementing steps (i) and (ii), we analytically identify a Pareto set of parent pairs that will receive the entire breeding budget at optimality. Since we wish to estimate the Pareto set in step (i) as input to step (ii), we derive an asymptotically optimal simulation budget allocation to estimate the Pareto set that, in our numerical experiments, out-performs Multi-objective Optimal Computing Budget Allocation in reducing misclassifications. Given the estimated Pareto set, we provide a branch-and-bound algorithm to solve the estimated mating design problem. Our approach dramatically reduces the computational effort required to solve the mating design problem when compared with naïve methods.
Mental Health and Disasters: Resilience after Disaster

This introduction presents an overview of the key concepts discussed in the book Mental Health and Disasters. The book is the definitive reference on mental health and disasters. It focuses on the assessment and treatment of the full spectrum of psychopathologies associated with many different types of individual disasters. The book talks about the mental health consequences of disasters. It provides a synthesis of the current knowledge of the mental health effects of disaster. The book focuses on key aspects of vulnerability and resilience in the face of disasters. It overviews the scientific literature on the key known determinants of the mental health consequences of disasters. The book discusses the science of interventions after disasters, along with the barriers and challenges faced in providing mental health care services after these events. It presents detailed explorations of a number of sentinel natural, technological, and human-made disasters.
PENGARUH YOGA PRENATAL TERHADAP KECEMASAN SESAAT DALAM MENGHADAPI PERSALINAN PADA PRIMIGRAVIDA TRIMESTER III DIGALENIA MOM AND BABY CENTER KOTA BANDUNG

Kehamilan adalah suatu proses fisiologis yang alamiah, karena sudah kodratnya sebagai seorang wanita untuk hamil dan melahirkan, hal ini akan menjadi pengalaman baru bagi wanita yang baru menikah. Wanita hamil pertama kali disebut primigravida , hampir semua mengalami kekhawatiran, kecemasan, dan ketakutan baik selama hamil, saat menghadapi persalinan maupun setelah persalinan. Salah satu cara mengatasi kecemasan adalah dengan yoga menurut Perry, et al. (2010). Metode yang digunakan dalam penelitian ini adalah metode Quasi Eksperimental . Adapun tujuan dari penelitian ini adalah untuk mengetahui pengaruh yoga prenatal terhadap kecemasan sesaat menghadapi persalinan pada wanita primigravida member yoga prenatal galenia mom and baby center . Subjek penelitian ini adalah member baru peserta yoga prenatal berjumlah 16 orang. Pengumpulan data menggunakan alat ukur kecemasan sesaat yang didasarkan pada teori spielberger (1966). Alat ukur tersebut memiliki 20 item yang sudah diuji validitasnya serta memiliki reliabilitas 0,751. Berdasarkan pengolahan data diperoleh hasil menunjukan bahwa 87,5% atau 14 orang subjek memiliki kecemasan sesaat yang tinggi dan 12,5% atau sebanyak 2 orang subjek memiliki kecemasan sesaat yang rendah. Hasil perhitungan uji T-test menunjukan adanya perubahan yang signifikan, yoga prenatal terhadap penurunan tingkat kecemasan yakni sebesar 0,024 (<0,05).
Using Type-of-Relationship (ToR) Graphs to Select Disjoint Paths in Overlay Networks

Routing policies used in the Internet can be restrictive, limiting communication between source-destination pairs to one path, when often better alternatives exist. To avoid route flapping, recovery mechanisms may be dampened, making adaptation slow. Unstructured overlays have been widely proposed to mitigate the issues of path and performance failures in the Internet by routing through an indirect-path via overlay peer(s). Choice of alternate-paths in overlay networks is a challenging issue. Ensuring both availability and performance guarantees on alternate paths requires aggressive monitoring of all overlay paths using active probing; this limits scalability when the number of overlay-paths becomes large. An alternate technique to select an overlay-path is to bias its selection based on physical disjointness criteria to bypass the failure on primary-path. In this paper, we show how type-of-relationship (ToR)-Graphs can be used to select maximally-disjoint overlay-paths.
Real Coded Genetic Algorithm for Design of IIR Digital Filter with Conflicting Objectives

A solution methodology for the design of digital infinite impulse response (II R) filter considering multiple conflicting objectives has been proposed. The nucleus of the method is that multiple objectives can be attuned suitably, to optimize the performance in pass bands, stop bands and transition bands of IIR digital filters. The p roposed method uses multiobjective optimization approach for designing stable IIR filter using real-coded genetic algorithm (RCGA). Digital IIR filters are designed by minimizing magnitude response and phase response simultaneously, using weighted sum approach. The value of weights are searched using RCGA along with filter coefficients thus assigning different weight vector to each indiv idual population thereby finding multiple pareto-optimal solutions in one simulation run. The order of the filter is controlled by a contro l gene whose value is also optimized along with the filter coefficients to obtain optimum order of designed IIR filter. The compu tational experiments show that the proposed approach gives better digital IIR filters than the existing genetic algorithm based methods.
Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host

Differentiation of extracellular Leishmania promastigotes within their sand fly vector, termed metacyclogenesis, is considered to be essential for parasites to regain mammalian host infectivity. Metacyclogenesis is accompanied by changes in the local parasite environment, including secretion of complex glycoconjugates within the promastigote secretory gel and colonization and degradation of the sand fly stomodeal valve. Deletion of the stage-regulated HASP and SHERP genes on chromosome 23 of Leishmania major is known to stall metacyclogenesis in the sand fly but not in in vitro culture. Here, parasite mutants deficient in specific genes within the HASP/SHERP chromosomal region have been used to investigate their role in metacyclogenesis, parasite transmission and establishment of infection. Metacyclogenesis was stalled in HASP/SHERP mutants in vivo and, although still capable of osmotaxis, these mutants failed to secrete promastigote secretory gel, correlating with a lack of parasite accumulation in the thoracic midgut and failure to colonise the stomodeal valve. These defects prevented parasite transmission to a new mammalian host. Sand fly midgut homogenates modulated parasite behaviour in vitro, suggesting a role for molecular interactions between parasite and vector in Leishmania development within the sand fly. For the first time, stage-regulated expression of the small HASPA proteins in Leishmania (Leishmania) has been demonstrated: HASPA2 is expressed only in extracellular promastigotes and HASPA1 only in intracellular amastigotes. Despite its lack of expression in amastigotes, replacement of HASPA2 into the null locus background delays onset of pathology in BALB/c mice. This HASPA2-dependent effect is reversed by HASPA1 gene addition, suggesting that the HASPAs may have a role in host immunomodulation.
Securing Sustainable Price Stability: Should Credit Come Back from the Wilderness?

We argue that in order to achieve price stability in a sustainable way, central banks should consider paying greater attention to credit in their monetary policy strategies than is generally the case at present. Specifically, simply setting monetary policy so that a two-year inflation forecast is at the central bank's target may, on occasions, be less than optimal. In particular, the central bank may wish to deviate from such a strategy when developments in the financial system are exposing the macroeconomy to materially increased risk. Doing so calls for longer policy horizons together with an explicit incorporation into policy decisions of the balance of risks in the outlook. One important indicator that risk is building up is unusually sustained and rapid credit growth occurring alongside unusually sustained and large increases in asset prices ("financial imbalances"). Building on previous work, we show that empirical proxies for financial imbalances contain useful information about subsequent banking crises, output and inflation beyond traditional two-year policy horizons. On the basis of Taylor rule-type descriptions of policy, we also investigate the response of central banks to financial imbalances. We find evidence that, at least until recently, central banks generally either have not responded to imbalances systematically or, to the extent that they have, have done so asymmetrically, loosening policy further than normal in the face of their unwinding but not tightening it beyond normal as they build up.
Role of Ultrasonography ( “ Honeycomb Sign ” ) in Early Detection of Dengue Hemorrhagic Fever

Aim: This study was conducted to evaluate the early, specific ultrasonographic (USG) findings in clinically suspected dengue hemorrhagic fever (DHF) along with its prognostic value. Methods: From May 2009 to June 2012, 20 patients were referred with high-grade fever and abdominal pain. All the patients underwent immediate abdominal USG. A specific change – “Honeycomb” pattern in the thickened gallbladder (GB) wall (mostly in the fundal area) – on USG suggested the diagnosis of DHF, which was subsequently confirmed by serology in all patients. Treatment was stated on the bases of USG findings before the positive serology report. After starting treatment the USG on the 3rd day showed reduction in GB wall thickening, which was almost cleared by the 7th day in clinically improving patients. Results: All 20 patients had type-2 dengue fever, i.e., DHF Grades I and II, as confirmed after USG by platelet count and serologic tests. USG features included a much-thickened GB wall in all the patients, but showing a “Honeycomb” pattern (proposed as Sachar and Sunder’s sign) in 19 patients (95%), multilayered (laminated/onion peel) in 1 patient (5%), ascites in 15 patients (75%), splenomegaly in 8 patients (40%), and pleural effusion in 14 patients (70%). (Pleural effusion was either right-sided or bilateral, but never alone on the left side.) Conclusions: Abdominal emergency USG can be used as a first-line imaging modality in patients with suspected DHF to detect early signs that are suggestive of the disease prior to obtaining serologic confirmation test results, especially in a dengue fever epidemic area. Also, reducing GB wall thickness can be used as a prognostic sign in cases of DHF.