Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of myocardial viability as detected by positron emission tomography in patients with ischemic cardiomyopathy.

Background —Detection of myocardial viability is important in patients with ischemic cardiomyopathy. Restoration of blood flow to viable myocardium is associated with improved left ventricular function and improved patient prognosis. However, the prevalence of viable myocardium in patients with ischemic cardiomyopathy is unknown. Methods and Results —To determine the prevalence of myocardial viability, clinical [ 13 N]ammonia/ 18 F-deoxyglucose PET studies performed in 283 patients (age, 63 (cid:54) 10 years) with ischemic heart disease (mean ejection fraction, 26 (cid:54) 8%) were visually analyzed for the presence and extent of viable and nonviable myocardium. The myocardium was divided into 19 segments. The extent of viable myocardium was considered “functionally” significant if (cid:36) 5 segments ( (cid:39) 25% of the left ventricular myocardium) exhibited a blood flow/metabolism mismatch and “prognostically” significant if 1 to 4 left ventricular segments did so. Of all patients, 41% had no evidence of viable myocardium, 55% had viable myocardium, and 4% had normal blood flow and metabolism within an enlarged left ventricle. Functionally significant viability was found in 27% and prognostically significant viability in 28% of the patients. Multivariate analysis revealed the presence of angina to be the only clinical parameter associated with the presence of functionally significant viability. Conclusions —Revascularization might improve patient prognosis in 55% and result in improved left ventricular function in 27% of all patients with ischemic cardiomyopathy. Circulation Additionally, stepwise logistic regression was performed to determine which independent variables might be associated with the presence of viable myocardium. The BMDP statistical software package 11 was used for data analysis. The Wilcoxon rank-sum test was used to compare relative reductions in myocardial blood flow between viable and nonviable myocardium. The (cid:120) 2 test was used to compare the frequency of possible flow reductions occurring in viable and nonviable myocar- dium. A value of P (cid:44) 0.05 was considered statistically significant.
Overpressuring mechanisms in the Yinggehai Basin, South China Sea

Yinggehai Basin is an elongate Cenozoic rift basin on the northwestern margin of the South China Sea continental shelf. Its thick (17 km) basin fill is characterized by high geothermal gradient and high overpressure. Overpressure associated with nonequilibrium compaction mainly occurs at depths more than 2800 m at the basin center and more than 4000 m at the basin margin because the shallow-buried Neogene and Quaternary strata lack effective seals. This regional overpressure distribution, however, is disrupted at basin center where high overpressure occurs in permeable formations at a depth as shallow as 1400 m on top of a series of deep-seated faults and fractures. We studied the processes and mechanisms of overpressuring via numerical modeling that couples basin filling, sediment compaction, and thermal and pressure fields to approach the origin of the shallow high overpressure. Model results indicated that an increase of fluid volume due to natural-gas generation by organic cracking is not large enough to generate the overpressure because of the limited amount of organic matter. The shallow overpressure has probably been generated allogenically. Deep open faults have served as vertical hydraulic conduits and channeled the deep high pressure into shallow permeable formations.
Cell Size at S Phase Initiation: An Emergent Property of the G1/S Network

The eukaryotic cell cycle is the repeated sequence of events that enable the division of a cell into two daughter cells. It is divided into four phases: G1, S, G2, and M. Passage through the cell cycle is strictly regulated by a molecular interaction network, which involves the periodic synthesis and destruction of cyclins that bind and activate cyclin-dependent kinases that are present in nonlimiting amounts. Cyclin-dependent kinase inhibitors contribute to cell cycle control. Budding yeast is an established model organism for cell cycle studies, and several mathematical models have been proposed for its cell cycle. An area of major relevance in cell cycle control is the G1 to S transition. In any given growth condition, it is characterized by the requirement of a specific, critical cell size, PS, to enter S phase. The molecular basis of this control is still under discussion. The authors report a mathematical model of the G1 to S network that newly takes into account nucleo/cytoplasmic localization, the role of the cyclin-dependent kinase Sic1 in facilitating nuclear import of its cognate Cdk1-Clb5, Whi5 control, and carbon source regulation of Sic1 and Sic1-containing complexes. The model was implemented by a set of ordinary differential equations that describe the temporal change of the concentration of the involved proteins and protein complexes. The model was tested by simulation in several genetic and nutritional setups and was found to be neatly consistent with experimental data. To estimate PS, the authors developed a hybrid model including a probabilistic component for firing of DNA replication origins. Sensitivity analysis of PS provides a novel relevant conclusion: PS is an emergent property of the G1 to S network that strongly depends on growth rate.
An Adaptive Service Selection Approach to Service Composition

In service computing, the behavior of a service may evolve. When an organization develops a service-oriented application in which certain services are provided by external partners, the organization should address the problem of uninformed behavior evolution of external services. This paper proposes an adaptive framework that bars problematic external services to be used in the service-oriented application of an organization. We use dynamic WSDL information in public service registries to approximate a snapshot of a network of services, and apply link analysis on the snapshot to identify services that are popularly used by different service consumers at the moment. As such, service composition can be strategically formed using the highly referenced services. We evaluate our proposal through a simulation study. The results show that, in terms of the number of failures experienced by service consumers, our proposal significantly outperforms the random approach in selecting reliable services to form service compositions.
Climate Change on Twitter: Topics, Communities and Conversations about the 2013 IPCC Working Group 1 Report

In September 2013 the Intergovernmental Panel on Climate Change published its Working Group 1 report, the first comprehensive assessment of physical climate science in six years, constituting a critical event in the societal debate about climate change. This paper analyses the nature of this debate in one public forum: Twitter. Using statistical methods, tweets were analyzed to discover the hashtags used when people tweeted about the IPCC report, and how Twitter users formed communities around their conversational connections. In short, the paper presents the topics and tweeters at this particular moment in the climate debate. The most used hashtags related to themes of science, geographical location and social issues connected to climate change. Particularly noteworthy were tweets connected to Australian politics, US politics, geoengineering and fracking. Three communities of Twitter users were identified. Researcher coding of Twitter users showed how these varied according to geographical location and whether users were supportive, unsupportive or neutral in their tweets about the IPCC. Overall, users were most likely to converse with users holding similar views. However, qualitative analysis suggested the emergence of a community of Twitter users, predominantly based in the UK, where greater interaction between contrasting views took place. This analysis also illustrated the presence of a campaign by the non-governmental organization Avaaz, aimed at increasing media coverage of the IPCC report.
Initiation and Growth of Transverse Cracks and Edge Delamination in Composite Laminates Part 1. An Energy Method

This paper is concerned with the basic fracture mechanisms involved in matrix-dominated failures in fibrous composite laminates, Specifically, interlaminar fracture in the form of free-edge ply delamination and intra- laminar fracture in the form of multiple transverse cracks are investigated. In each case, a theory is formulated based on the classical linear fracture mechanics concept of strain energy release rate as a criterion for crack growth. A finite element technique incorporating the virtual crack-closure procedure is developed to generate numerical results. Simultaneously, an experimental study is conducted using a series of graphite epoxy laminates in the form of (±25/90 n ) s , n = 1,2,3. Part 1 of this paper presents the development of the method from the conceptual, physical and numerical considerations, while Part 2 provides for a comparison between the analyti cal and experimental results.
Respiratory infection risk in athletes: association with antigen‐stimulated IL‐10 production and salivary IgA secretion

The purpose of this study was to examine factors influencing susceptibility to upper respiratory tract infections (URTI) in 18–35‐year‐old men and women engaged in endurance‐based physical activity during the winter months. Eighty individuals (46 males, 34 females) provided resting blood and saliva samples for determination of markers of systemic immunity. Weekly training and illness logs were kept for the following 4 months. Thirty subjects did not experience an URTI episode and 24 subjects experienced 3 or more weeks of URTI symptoms. These illness‐prone subjects had higher training loads and had ∼2.5‐fold higher interleukin (IL)‐4 and IL‐10 production by antigen‐stimulated whole blood culture than the illness‐free subjects. Illness‐prone subjects also had significantly lower saliva S‐IgA secretion rate and higher plasma IgM (but not IgA or IgG) concentration than the illness‐free subjects. There were no differences in circulating numbers of leukocyte subtypes or lymphocyte subsets between the illness‐prone and illness‐free subjects. The production of IL‐10 was positively correlated and the S‐IgA secretion rate was negatively correlated with the number of weeks with infection symptoms. It is concluded that high IL‐10 production in response to antigen challenge and low S‐IgA secretion are risk factors for development of URTI in physically active individuals.
Recent Advances in Postoperative Pain Management

Good pain control after surgery is important to prevent negative outcomes such as tachycardia, hypertension, myocardial ischemia, decrease in alveolar ventilation, and poor wound healing. Exacerbations of acute pain can lead to neural sensitization and release of mediators both peripherally and centrally. Clinical wind up occurs from the processes of N-Methyl D-Aspartate (NMDA) activation, wind up central sensitization, long-term potentiation of pain (LTP), and transcription-dependent sensitization. Advances in the knowledge of molecular mechanisms have led to the development of multimodal analgesia and new pharmaceutical products to treat postoperative pain. The new pharmacological products to treat postoperative pain include extended-release epidural morphine and analgesic adjuvants such as capsaicin, ketamine, gabapentin, pregabalin dexmetomidine, and tapentadol. Newer postoperative patient-controlled analgesia (PCA) in modes such as intranasal, regional, transdermal, and pulmonary presents another interesting avenue of development.
Isolation of a Mutant of Escherichia coli with a Temperature-sensitive Fructose-1,6-Diphosphate Aldolase Activity

Böck, August (Purdue University, Lafayette, Ind.), and Frederick C. Neidhardt. Isolation of a mutant of Escherichia coli with a temperature-sensitive fructose-1,6-diphosphate aldolase activity. J. Bacteriol. 92:464–469. 1966. —A mutant of Escherichia coli was isolated which was able to grow in rich medium at 30 C but not at 40 C. Upon exposure to 40 C, the cells immediately stopped ribonucleic acid (RNA) and deoxyribonucleic acid synthesis, but protein synthesis continued at a diminished rate for a short time. Addition of chloramphenicol did not release RNA synthesis from inhibition at 40 C. Synthesis of β-galactosidase could be induced at high temperature despite the presence of glucose in the medium, indicating a lesion in glucose catabolism. Of many catabolic enzymes tested in cell-free extracts, only fructose-1,6-diphosphate aldolase activity appeared to be altered in the mutant cells. No activity was demonstrable in extracts of mutant cells grown at either 30 or 40 C, but determination of glucose-oxidation patterns revealed that the enzyme is probably active in vivo at 30 C. Temperature-resistant secondary mutants were found to have partially or fully restored aldolase activity, and temperature-resistant recombinants had normal aldolase activity, indicating that the growth pattern and the altered aldolase had a common genetic basis. Linkage data permitted the assignment of an approximate map location for the mutated aldolase gene.
Divergent Roles of Amino Acid Residues Inside and Outside the BB Loop Affect Human Toll-Like Receptor (TLR)2/2, TLR2/1 and TLR2/6 Responsiveness

TLR2 specifically recognizes a wide range of ligands by homodimerizing or heterodimerizing with TLR1 or TLR6. However, the molecular basis of the specific signalling transduction induced by TLR2 homodimerization or heterodimerization with TLR1 or TLR6 is largely unknown. In this study, we found three amino acid residues, two (663L and 688N) outside and one (681P) inside the BB loop, which were conserved in all of the TLRs, except for the TLR3 toll/IL-1R(TIR) domain. The responsiveness of human TLR2/2, TLR2/1 or TLR2/6 was completely lost when 663L and 688N were replaced with the corresponding amino acid residues in the TLR3 TIR domain, respectively. However, the response of TLR2 (P681A) to the high concentration of TLR2/TLR6 agonist was almost intact, but the activity of TLR2 (P681A) was greatly reduced when stimulated with the TLR2/1 agonist or the TLR2/2 agonist. Although the surface expression of TLR2 (L663E) was sharply reduced, both the intracellular distribution and the surface expression of all of the other TLR2 mutants were unchanged. The ability of all three TLR2 mutants to recruit MyD88, was consistent with their responsivenesses. Computer modelling indicated that the surface negative charge of all of the TLR2 mutants' BB loops was reduced. Thus, our data demonstrated that the 663L and 688N residues outside of the BB loop were essential for the responsiveness of TLR2/2, TLR2/1 and TLR2/6, but the 681P residue inside of the BB loop exhibited divergent roles in TLR2/2, TLR2/1 and TLR2/6 signalling transduction, thereby providing clues regarding the specific signalling transduction of TLR2/2, TLR2/1 and TLR2/6.
Extending Java for high-level Web service construction

We incorporate innovations from the <bigwig> project into the Java language to provide high-level features for Web service programming. The resulting language, JWIG, contains an advanced session model and a flexible mechanism for dynamic construction of XML documents, in particular XHTML. To support program development we provide a suite of program analyses that at compile time verify for a given program that no runtime errors can occur while building documents or receiving form input, and that all documents being shown are valid according to the document type definition for XHTML 1.0. We compare JWIG with Servlets and JSP which are widely used Web service development platforms. Our implementation and evaluation of JWIG indicate that the language extensions can simplify the program structure and that the analyses are sufficiently fast and precise to be practically useful.
Intensive Case Finding and Isoniazid Preventative Therapy in HIV Infected Individuals in Africa: Economic Model and Value of Information Analysis

Background Tuberculosis (TB) accounts of much of the morbidity and mortality associated with HIV. We evaluate the cost-effectiveness of different strategies to actively screen for TB disease in HIV positive individuals, where isoniazid preventative therapy (IPT) is given to those screening negative, and use value of information analysis (VOI) to identify future research priorities. Methodology/ Principal Findings We built an individual sampling model to investigate the costs (2010 US Dollars) and consequences of screening for TB, and providing TB treatment or IPT in adults testing HIV positive in Sub-Saharan Africa. A systematic review and meta-analysis was conducted to assess performance of the nine different TB screening strategies evaluated. Probabilistic sensitivity analysis was conducted to incorporate decision uncertainty, and expected value of perfect information for the entire model and for groups of parameters was calculated. Screening all HIV infected individuals with sputum microscopy was the least costly strategy, with other strategies not cost-effective at WHO recommended thresholds. Screening those with TB symptoms with sputum microscopy and CXR would be cost-effective at a threshold ICER of $7,800 per quality-adjusted life year (QALY), but associated with significant uncertainty. VOI analysis suggests further information would be of value. Conclusions/ Significance Resource-constrained countries in sub-Saharan Africa wishing to scale up TB preventative services in their HIV infected populations should consider expanding laboratory facilities to enable increased screening for TB with sputum microscopy, whilst improved estimates of the TB prevalence in the population to be screened are needed, as it may influence the optimal strategy.
Olfactometric Evaluation of Spatial Repellents for Aedes aegypti

Abstract The spatial repellency responses of Aedes aegypti (L.) to deet, dehydrolinalool and linalool were evaluated using a dual port olfactometer. In the absence of human attractant mixture, each of the three chemicals resulted in activation and/or orientation of mosquitoes to the chemical source. Linalool was the most attractive compound. In the presence of human attractant mixture, activation and/or orientation of mosquitoes to each of the three chemicals was reduced. We compared reductions in mosquito responses to each of the three chemicals, in the presence of human attractant mixture, to estimate spatial repellency. As expected, lowest spatial repellency (7.3%) was observed using human attractant alone. Highest spatial repellency (33.6%) was observed using a combination of linalool and dehydrolinalool. Deet did not manifest spatial repellency, whereas linalool and dehydrolinalool alone, and in combination, exhibited spatial repellency.
Determining the torus covering factors for a sample of type 1 AGN in the local Universe.

In the unified scheme of active galactic nuclei, a dusty torus absorbs and then reprocesses a fraction of the intrinsic luminosity which is emitted at longer wavelengths. Thus, subject to radiative transfer corrections, the fraction of the sky covered by the torus as seen from the central source (known as the covering factor fc) can be estimated from the ratio of the infrared to the bolometric luminosities of the source as fc = Ltorus/LBol. However, the uncertainty in determining LBol has made the estimation of covering factors by this technique difficult, especially for AGN in the local Universe where the peak of the observed spectral energy distributions lies in the UV (ultraviolet). Here, we determine the covering factors of an X-ray/optically selected sample of 51 type 1 AGN. The bolometric luminosities of these sources are derived using a self-consistent, energy-conserving model that estimates the contribution in the unobservable far-UV region, using multifrequency data obtained from SDSS, XMM–Newton, WISE, 2MASS and UKIDSS. We derive a mean value of fc ∼ 0.30 with a dispersion of 0.17. Sample correlations, combined with simulations, show that fc is more strongly anticorrelated with λEdd than with LBol. This points to large-scale torus geometry changes associated with the Eddington-dependent accretion flow, rather than a receding torus, with its inner sublimation radius determined solely by heating from the central source. Furthermore, we do not see any significant change in the distribution of fc for sub-samples of radio-loud sources or Narrow Line Seyfert 1 galaxies (NLS1s), though these sub-samples are small.
Açaí (Euterpe oleracea Mart.): A Tropical Fruit with High Levels of Essential Minerals—Especially Manganese—and its Contribution as a Source of Natural Mineral Supplementation

Açaí is a fruit from the Brazilian Amazon region, with an exotic flavor, possessing high antioxidant and anti-inflammatory properties. Based on these properties, the fruit is classified as one of the new “super fruits. ” The mean daily consumption of açai pulp may reach 300 ml in several Brazilian regions. Further, this fruit is also gaining popularity in Europe and North America. In this context, the aim of this study was to assess the levels of some essential minerals in freeze-dried açaí pulp obtained in different Brazilian locations. It was found that açaí pulp is rich in essential minerals (Ca, Fe, Mg, Zn), but the levels of copper (Cu) and especially manganese (Mn) are surprisingly markedly higher than the traditional sources of these elements in the human diet. A daily consumption of 300 ml açaí pulp leads to a Mn daily intake exceeding at least sixfold (14.6 mg on average) the reference daily intake for an adult. Consequently, Mn intake may surpass the permitted daily maximum intake of 11 mg, which leads to a special concern, particularly for children, vegetarians, and individuals with anemia, since iron (Fe) absorption is impaired by Mn. Our findings demonstrate that this fruit is a potential source of several nutrients and a good dietary supplement to resolve malnutrition problems. However, due to the expressive levels of Mn, further studies are necessary to evaluate potential adverse effects associated with açaí consumption.
Electron tomography of the microtubule cytoskeleton in multinucleated hyphae of Ashbya gossypii

Summary We report the mechanistic basis guiding the migration pattern of multiple nuclei in hyphae of Ashbya gossypii. Using electron tomography, we reconstructed the cytoplasmic microtubule (cMT) cytoskeleton in three tip regions with a total of 13 nuclei and also the spindle microtubules of four mitotic nuclei. Each spindle pole body (SPB) nucleates three cMTs and most cMTs above a certain length grow according to their plus-end structure. Long cMTs closely align for several microns along the cortex, presumably marking regions where dynein generates pulling forces on nuclei. Close proximity between cMTs emanating from adjacent nuclei was not observed. The majority of nuclei carry duplicated side-by-side SPBs, which together emanate an average of six cMTs, in most cases in opposite orientation with respect to the hyphal growth axis. Such cMT arrays explain why many nuclei undergo short-range back and forth movements. Only occasionally do all six cMTs orient in one direction, a precondition for long-range nuclear bypassing. Following mitosis, daughter nuclei carry a single SPB with three cMTs. The increased probability that all three cMTs orient in one direction explains the high rate of nuclear bypassing observed in these nuclei. The A. gossypii mitotic spindle was found to be structurally similar to that of Saccharomyces cerevisiae in terms of nuclear microtubule (nMT) number, length distribution and three-dimensional organization even though the two organisms differ significantly in chromosome number. Our results suggest that two nMTs attach to each kinetochore in A. gossypii and not only one nMT like in S. cerevisiae.