Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutrient profiles of commercial goat milk cheeses manufactured in the United States.

Thirty varieties of commercial goat milk cheeses collected from 13 manufacturers in 11 states of the US were evaluated. Concentration profiles of basic nutrients, major and trace minerals, their correlations, and mineral ratios in the caprine cheeses were determined to compare nutritional parameters among the varieties. Mean percentage of moisture, fat, protein, and ash for plain soft, semi-soft, hard, pepper, garlic, and herb cheeses were 59.8, 22.5, 18.9, 1.74; 43.2, 28.5, 26.2, 2.83; 27.4, 32.3, 25.4, 3.58; 57.3, 22.9, 21.6, 1.32; 64.3, 18.3, 16.7, 1.34; 59.1, 21.8, 17.3, 1.60, respectively. Ranges of mean concentrations (mg/100 g wet basis) of S, P, K, Mg, Ca, Na, Cl, Fe, Al, Mn, Cu, and Zn were: 2.00 to 8.05; 192 to 785; 7.03 to 103; 10.3 to 78.0; 57.1 to 1035; 225 to 924; 96.0 to 1260; . 52 to 8.73; . 47 to 22.1; . 08 to . 40; . 44 to 1.32; . 49 to 4.13, respectively. Twenty of the 30 varieties were very high or high moisture cheeses, which would suggest slow coagulation as the major mode of fabrication. Wide variations in the concentrations of P, K, Ca, Na, Cl, Fe, Al, and Zn were found among and within varieties of the cheeses. High concentrations and variations in Fe and Al in the cheeses indicate a significant possibility of uptake of these elements into the products during farmstead manufacturing processes. Percentage of moisture was negatively and significantly (P less than .05 or P less than .01) correlated with the concentrations of ash, fat, protein, and most of the minerals. Percentage of ash was positively and significantly correlated with the concentrations of macrominerals but negatively and less correlated with concentrations of Fe, Al, Mn, and Cu. The Na:K ratio was the highest of the five mineral ratios. Differences were significant for Ca:P, Ca:Mg, and Na:K ratios among the six types of goat cheese tested.
Contact-induced redistribution of specific membrane components: local accumulation and development of adhesion

We have used a model system to explore the importance of long-range lateral diffusion of membrane proteins in specific membrane-membrane adhesion. Single, cell-size phospholipid vesicles containing a dinitrophenyl (DNP)-lipid hapten were maneuvered into contact with rat basophilic leukemia (RBL) cells carrying fluorescent anti-DNP IgE in their cell-surface Fc epsilon receptors. Upon cell-vesicle contact the antibody molecules underwent a marked lateral redistribution, accumulating at the site of contact and becoming significantly depleted from noncontacting membrane. As assayed with a micropipette suction method, there was a time-dependent increase in the strength of cell- vesicle adhesion. This development of adhesion paralleled the kinetics of accumulation of the adhesion-mediating antibody molecules at the zone of membrane-membrane contact. Both adhesion and redistribution were absolutely dependent upon a specific interaction of the IgE with the hapten: No redistribution occurred when vesicles lacking the DNP hapten were pushed against IgE-armed RBL cells, and on cells bearing a 1:1 mixture of nonimmune rat IgE and anti-DNP mouse IgE, only the latter underwent redistribution. Vesicles containing DNP-lipids bound to RBL cells carrying anti-DNP IgE but not to cells carrying nonimmune rat IgE. Measurable nonspecific binding did not develop even after 15 min of pushing DNP-bearing vesicles against RBL cells sensitized with nonimmune IgE. Neither redistribution nor adhesion was blocked by metabolic poisons such as NaN3 and NaF. Both redistribution and adhesion occurred in plasma membrane blebs previously shown to lack cytoskeletal filaments. The above observations are consistent with contact-induced redistribution of the IgE being a result of passive diffusion-mediated trapping rather than active cellular responses. Thus, long-range diffusion of specific proteins can in some cases contribute to the formation of stable adhesion between membranes.
The importance of fatty liver disease in clinical practice

The worldwide obesity epidemic over the last 20 years has led to a dramatic increase in the prevalence of non-alcoholic fatty liver disease, the hepatic manifestation of the metabolic syndrome. Estimates of prevalence vary depending on the population studied and the methods used to assess hepatic fat content, but are commonly quoted as between 10 and 30% of the adults in the Western hemisphere. Fatty liver develops when fatty acid uptake and synthesis in the liver exceeds fatty acid oxidation and export as TAG. Studies of pathogenesis point to insulin resistance, lipotoxicity, oxidative stress and chronic inflammation being central to the development and progression of the disease. A proportion of individuals with fatty liver develop progressive disease, though large prospective longitudinal studies are lacking. Nevertheless, fatty liver is associated with increased all-cause and liver-related mortality compared with the general population. Management of fatty liver centres around lifestyle and dietary measures to induce controlled and sustained weight loss. Management of cardiovascular risk factors aims to reduce mortality, while certain dietary interventions have been shown to reduce steatosis and inflammation. Specific pharmacological treatments also show promise, but their use is not widespread. A multi-system and multi-disciplinary approach to the management of this disorder is proposed.
Theoretical energy-conversion efficiency for multi-stage RF energy harvesters

A model has been developed through closed-form equations which simply determines the theoretical output power and energy-conversion efficiency for an RF-to-dc energy harvesting circuit with N rectifying elements. This model improves on previous works which are limited to evaluating circuits with only a single rectifying element or a single frequency excitation. Validation has been obtained through the simulation of circuits with ideal components which show good agreement for harvesters with up to 6 diodes along with measurements of a 5.8 GHz voltage doubler which show agreement to within 5.6%. The relationships between the number of stages and output loads is discussed, and the theoretical maximum efficiency for a harvester with N ideal rectifying elements is presented.
Visual Discomfort and Visual Fatigue of Stereoscopic Displays: A Review

Visual discomfort has been the subject of considerable research in relation to stereoscopic and autostereoscopic displays. In this paper, the importance of various causes and aspects of visual discomfort is clarified. When disparity values do not surpass a limit of 1°, which still provides sufficient range to allow satisfactory depth perception in stereoscopic television, classical determinants such as excessive binocular parallax and accommodation-vergence conflict appear to be of minor importance. Visual discomfort, however, may still occur within this limit and we believe the following factors to be the most pertinent in contributing to this: (1) temporally changing demand of accommodation-vergence linkage, e.g., by fast motion in depth; (2) three-dimensional artifacts resulting from insufficient depth information in the incoming data signal yielding spatial and temporal inconsistencies; and (3) unnatural blur. In order to adequately characterize and understand visual discomfort, multiple types of measurements, both objective and subjective, are required.
Egg survival in immature rat ovaries grafted after freezing and thawing

Immature rat ovaries grafted subcutaneously after freezing and thawing show a heavy loss of eggs. A number of variations in the freezing technique have been tried but have not led to any substantial increase in egg survival. Similarly treated ovaries may show a wide variation as grafts. Methods for estimating and comparing the effects of different freezing techniques on the eggs have been worked out.
Ultrasmooth metallic foils for growth of high quality graphene by chemical vapor deposition

Synthesis of graphene by chemical vapor deposition is a promising route for manufacturing large-scale high-quality graphene for electronic applications. The quality of the employed substrates plays a crucial role, since the surface roughness and defects alter the graphene growth and cause difficulties in the subsequent graphene transfer. Here, we report on ultrasmooth high-purity copper foils prepared by sputter deposition of Cu thin film on a SiO2/Si template, and the subsequent peeling off of the metallic layer from the template. The surface displays a low level of oxidation and contamination, and the roughness of the foil surface is generally defined by the template, and was below 0.6 nm even on a large scale. The roughness and grain size increase occurred during both the annealing of the foils, and catalytic growth of graphene from methane (≈1000 °C), but on the large scale still remained far below the roughness typical for commercial foils. The micro-Raman spectroscopy and transport measurements proved the high quality of graphene grown on such foils, and the room temperature mobility of the graphene grown on the template stripped foil was three times higher compared to that of one grown on the commercial copper foil. The presented high-quality copper foils are expected to provide large-area substrates for the production of graphene suitable for electronic applications.
Genome Sequence of Nitrosomonas communis Strain Nm2, a Mesophilic Ammonia-Oxidizing Bacterium Isolated from Mediterranean Soil

ABSTRACT The complete genome sequence of Nitrosomonas communis strain Nm2, a mesophilic betaproteobacterial ammonia oxidizer isolated from Mediterranean soils in Corfu, Greece, is reported here. This is the first genome to describe a cluster 8 Nitrosomonas species and represents an ammonia-oxidizing bacterium commonly found in terrestrial ecosystems.
The timing of demise in fetuses with trisomy 21 and trisomy 18

Women with chromosomally abnormal fetuses often choose to continue their pregnancy. However, though they may search for specific details whether their fetus will survive, not much information is available. We sought to determine if there was a pattern for timing of demise and to determine if demise was more likely to occur before viability in fetuses with amniocentesis confirmed trisomy 18 or 21.
Realistic Approach towards Quantitative Analysis and Simulation of EEHC-Based Routing for Wireless Sensor Networks

This paper presents the realistic approach towards the quantitative analysis and simulation of Energy Efficient Hierarchical Cluster (EEHC)-based routing for wireless sensor networks. Here the efforts have been done to combine analytical hardware model with the modified EEHC-based routing model. The dependence of various performance metrics like: optimum number of clusters, Energy Consumption, and Energy consumed per round etc. based on analytical hardware sensor model and EEHC model has been presented.
Increased Intrinsic Connectivity of the Default Mode Network in Temporal Lobe Epilepsy: Evidence from Resting-State MEG Recordings

The electrophysiological signature of resting state oscillatory functional connectivity within the default mode network (DMN) during spike-free periods in temporal lobe epilepsy (TLE) remains unclear. Using magnetoencephalographic (MEG) recordings, this study investigated how the connectivity within the DMN was altered in TLE, and we examined the effect of lateralized TLE on functional connectivity. Sixteen medically intractable TLE patients and 22 controls participated in this study. Whole-scalp 306-channel MEG epochs without interictal spikes generated from both MEG and EEG data were analyzed using a minimum norm estimate (MNE) and source-based imaginary coherence analysis. With this processing, we obtained the cortical activation and functional connectivity within the DMN. The functional connectivity was increased between DMN and the right medial temporal (MT) region at the delta band and between DMN and the bilateral anterior cingulate cortex (ACC) regions at the theta band. The functional change was associated with the lateralization of TLE. The right TLE showed enhanced DMN connectivity with the right MT while the left TLE demonstrated increased DMN connectivity with the bilateral MT. There was no lateralization effect of TLE upon the DMN connectivity with ACC. These findings suggest that the resting-state functional connectivity within the DMN is reinforced in temporal lobe epilepsy during spike-free periods. Future studies are needed to examine if the altered functional connectivity can be used as a biomarker for treatment responses, cognitive dysfunction and prognosis in patients with TLE.
Better, Stronger, Faster: Self-Serving Judgment, Affect Regulation, and the Optimal Vigilance Hypothesis

Self-serving judgments, in which the self is viewed more favorably than other people, are ubiquitous. Their dynamic variation within individuals may be explained in terms of the regulation of affect. Self-serving judgments produce positive emotions, and threat increases self-serving judgments (a compensatory pattern that restores affect to a set point or baseline). Perceived mutability is a key moderator of these judgments; low mutability (i.e., the circumstance is closed to modification) triggers a cognitive response aimed at affect regulation, whereas high mutability (i.e., the circumstance is open to further modification) activates direct behavioral remediation. Threats often require immediate response, whereas positive events do not. Because of this brief temporal window, an active mechanism is needed to restore negative (but not positive) affective shifts back to a set point. Without this active reset, an earlier threat would make the individual less vigilant toward a new threat. Thus, when people are sad, they aim to return their mood to baseline, often via self-serving judgments. We argue that asymmetric homeostasis enables optimal vigilance, which establishes a coherent theoretical account of the role of self-serving judgments in affect regulation.
Inteligência: Avanços nos Modelos Teóricos e nos Instrumentos de Medida Intelligence: Advances in Theoretical Models and in Measurement Instruments

Resumo Este artigo procura discutir alguns avancos cientificos na area da avaliacao da inteligencia contrapondo-os as ideias que sao divulgadas na midia. Pretende-se abordar alguns mal entendidos que fazem a pratica divergir da ciencia. Trata-se primeiro da evolucao do estudo da inteligencia, especialmente na abordagem psicometrica apresentando o modelo de Cattell-Horn-Carroll (CHC). Trata-se em seguida de estudos mais recentes no sobre o construto inteligencia emocional integrando achados da psicologia e da neurociencia falando sobre as relacoes entre a cognicao e a emocao. Palavras chave: avaliacao da inteligencia, inteligencia emocional, Teoria Cattell-Horn-Carroll, neurociencia.
Utility of a Dengue-Derived Monoclonal Antibody to Enhance Zika Infection In Vitro

Introduction: Zika virus (ZIKV) has emerged in dengue (DENV) endemic areas, where these two related flaviviruses continue to co-circulate. DENV is a complex of four serotypes and infections can progress to severe disease. It is thought that this is mediated by antibody dependent enhancement (ADE) whereby antibodies from a primary DENV infection are incapable of neutralizing heterologous DENV infections with another serotype. ADE has been demonstrated among other members of the Flavivirus group. Methods: We utilize an in vitro ADE assay developed for DENV to determine whether ZIKV is enhanced by a commonly available DENV serotype 2-derived monoclonal antibody (4G2). Results: We show that ZIKV infection in vitro is enhanced in the presence of the 4G2 mAb. Discussion: Our results demonstrate that ADE between ZIKV and DENV is possible and that the 4G2 antibody is a useful tool for the effects of pre-existing anti-DENV antibodies during ZIKV infections.
An Open Trial Investigation of Emotion Detectives: A Transdiagnostic Group Treatment for Children with Anxiety and Depression

of a thesis at the University of Miami Thesis supervised by Assistant Professor Jill Ehrenreich May. No. of pages in text. (76) Anxiety and depressive disorders are prevalent among youth and are often experienced concurrently or sequentially during development (Kroes et al., 2001; Costello, Erklani, & Angold, 2006). These disorders are also associated with weaker cognitive behavioral treatment (CBT) outcomes when experienced simultaneously in youth (e.g. Berman, Weems, Silverman, & Kurtines, 2000). Treatment research has begun to investigate the feasibility and efficacy of treating comorbid emotional disorders using transdiagnostic treatment approaches (Barlow et al., 2010; Ehrenreich et al., 2008). Evidence from adult and adolescent populations indicates that these more broadly focused treatment programs may offer benefits above and beyond disorderand domainspecific protocols, leading to improvements in diagnostic severity and emotion regulation across a range of disorders and emotions (Ellard, Fairholme, Boisseau, Farchione, & Barlow, 2010; Ehrenreich-May & Remmes, 2010). The current study extends transdiagnostic treatment research to school-age children, ages 7-12, in a mental health clinic setting by investigating preliminary post-treatment outcomes and treatment acceptability in a recent open trial (N enrolled= 16; N completed treatment=13) of the Emotion Detectives Treatment Protocol (EDTP; Ehrenreich-May & Laird, 2009). Results revealed that participants experienced significant improvements in clinical severity ratings of principal and all related diagnoses, as well as in parent reported anxious and parent and child reported depressive symptoms at the post-treatment assessment. Additionally, parents reported gains in child coping and improvements in dysregulation across emotional domains (including worry, sadness, and anger). T he EDTP had good retention rates, moderately good attendance, and parents and children reported high levels of treatment satisfaction. The results of this open trial provide preliminary evidence for the utility and acceptability of a transdiagnostic group protocol to treat both clinical anxiety disorders, as well as selfand parent-reported anxious and depressive symptoms for youth within a mental health setting. These results suggest that children may uniquely benefit from a more generalized, emotion-focused treatment modality, such as the EDTP, that can offer flexibility in its treatment targets to families as well as mental health
Enhanced suppression of polyclonal CD8+25+ regulatory T cells via exosomal arming of antigen‐specific peptide/MHC complexes

Compared with CD4+25+ regulatory T cells (Tregs), the mechanisms for natural, polyclonal CD8+25+ Treg immune suppression have been significantly less studied. We previously showed that polyclonal T cells can acquire antigen‐specific targeting activity through arming with exosomal peptide‐MHC (pMHC). In this study, we assessed the suppressive effect of CD8+25+ Tregs or CD8+25+ Tregs armed with ovalbumin (OVA)‐specific exosomes on other immune cells and OVA‐specific dendritic cell (DCOVA)‐stimulated antitumor immunity. We demonstrate that CD8+25+ Tregs inhibit T cell proliferation in vitro in a cell contact‐dependent fashion but independent of the expression of immunosuppressive IL‐10, TGF‐β, and CTLA‐4. CD8+25+ Tregs anergize naïve T cells upon stimulation by up‐regulating T cell anergy‐associated Egr2 and down‐regulating IL‐2 production. Tregs also anergize DCs by preventing DC maturation through the down‐regulation of Iab, CD80, CD86, and inflammatory cytokines, leading to defects in T cell stimulation. Moreover, CD8+25+ Tregs inhibit CTLs through inducing CTL death via perforin‐mediated apoptosis and through reducing effector CTL cytotoxic activity via down‐regulating CTL perforin‐production and degranulation. In addition, we show that CD8+25+ Tregs suppress DCOVA‐stimulated CTL responses in priming and effector phases and inhibit immunity against OVA‐expressing CCLOVA lung cancer. Remarkably, polyclonal CD8+25+ Tregs armed with OVA‐specific exosomal pMHC class‐II (pMHC‐II), or pMHC class‐I (pMHC‐I) complexes exert their enhanced inhibition of CTL responses in the priming and the effector phases, respectively. Taken together, our investigation reveals that assigning antigen specificity to nonspecific polyclonal CD8+25+ Tregs for enhanced immune suppression can be achieved through exosomal pMHC arming. This principle may have a great effect on Treg‐mediated immunotherapy of autoimmune diseases.
On the Degrees of Freedom of SISO X-networks with Synergistic Alternating Channel State Information at transmitters

In this paper, we consider the two-user single-input single-output (SISO) X-channel and $K$-user SISO X-network in fast fading environment. It is assumed that the transmitters have access to synergistic alternating channel state information (CSI). Specifically, the CSIT alternates between three states, namely, perfect, delayed and no-CSIT, in a certain manner to enable these states to work together cooperatively. These states are associated with fractions of time denoted by $\lambda_P$, $\lambda_D$ \text{and} $\lambda_N$, respectively. For the two-user $X$-channel, simple upper bound is developed to prove the tightness of the achievability result of $4/3$ DoF under a certain distribution of the availability of three CSIT states for $\Lambda(\lambda_P=1/3, \lambda_D= 1/3, \lambda_N=1/3)$. For the $K$-user $X$-network, it is shown that the sum Degrees of freedom (DoF) is at least $2K/(K + 1)$, using two-phase transmission schemes over finite symbols channel extension and under the same distribution of the availability of $\Lambda(\lambda_P=1/3, \lambda_D= 1/3, \lambda_N=1/3)$. This achievability result, can be considered as a tight lower bound, coincides with the best lower bound known for the same network but with partial output feedback in stead of alternating CSIT. Hence, we show that the role of synergistic alternating CSIT with distribution $\Lambda(1/3,1/3,1/3)$ is equivalent to the partial output feedback. Also, this lower bound is strictly better than the best lower bound known for the case of delayed CSI assumption for all values of $K$. All the proposed transmission schemes are based on two phases transmission strategy, namely, interference creation and interference resurrection, which exploit the synergy of instantaneous CSI and delay CSIT to retrospectively align interference in the subsequent channel uses.