Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship between trauma center volume and outcomes.

CONTEXT The premise underlying regionalization of trauma care is that larger volumes of trauma patients cared for in fewer institutions will lead to improved outcomes. However, whether a relationship exists between institutional volume and trauma outcomes remains unknown. OBJECTIVE To evaluate the association between trauma center volume and outcomes of trauma patients. DESIGN Retrospective cohort study. SETTING Thirty-one academic level I or level II trauma centers across the United States participating in the University Healthsystem Consortium Trauma Benchmarking Study. PATIENTS Consecutive patients with penetrating abdominal injury (PAI; n = 478) discharged between November 1, 1997, and July 31, 1998, or with multisystem blunt trauma (minimum of head injury and lower-extremity long-bone fractures; n = 541) discharged between June 1 and December 31, 1998. MAIN OUTCOME MEASURES Inpatient mortality and hospital length of stay (LOS), comparing high-volume (>650 trauma admissions/y) and low-volume (</=650 admissions/y) centers. RESULTS After multivariate adjustment for patient characteristics and injury severity, the relative odds of death was 0.02 (95% confidence interval [CI], 0.002-0.25) for patients with PAI admitted with shock to high-volume centers compared with low-volume centers. No benefit was evident in patients without shock (P =.50). The adjusted odds of death in patients with multisystem blunt trauma who presented with coma to a high-volume center was 0.49 (95% CI, 0.26-0.93) vs low-volume centers. No benefit was observed in patients without coma (P =.05). Additionally, a shorter LOS was observed in patients with PAI and New Injury Severity Scores of 16 or higher (difference in adjusted mean LOS, 1.6 days [95% CI, -1.5 to 4.7 days]) and in all patients with multisystem blunt trauma admitted to higher-volume centers (difference in adjusted mean LOS, 3.3 days [95% CI, 0.91-5.70 days]). CONCLUSIONS Our results indicate that a strong association exists between trauma center volume and outcomes, with significant improvements in mortality and LOS when volume exceeds 650 cases per year. These benefits are only evident in patients at high risk for adverse outcomes.
Signal Processing of Semicircular Canal and Otolith Signals in the Vestibular Nuclei during Passive and Active Head Movements

The vestibular nerve sends signals to the brain that code the movement and position of the head in space. These signals are used by the brain for a variety of functions, including the control of reflex and voluntary movements and the construction of a sense of self‐motion. If many of these functions are to be carried out, a distinction must be made between sensory vestibular signals related to active head movements and those related to passive head movements. Current evidence is that the distinction occurs at an early stage of sensory processing in the brain, and the results are evident in the firing behavior of neurons in the vestibular nuclei that receive direct inputs from the vestibular nerve. Several specific examples of how sensory information related to passive and active head movements is transformed in the vestibular nuclei are discussed.
Effects of polymer-coated metal oxide nanoparticles on goldfish (Carassius auratus L.) neutrophil viability and function

Abstract Exposure effects from polyacrylic acid (PAA) metal-oxide nanoparticles (TiO2, CeO2, Fe2O3, ZnO) on fish neutrophil viability and effector functions (degranulation, respiratory burst, inflammatory gene expression) were investigated using primary kidney goldfish (Carassius auratus L.) neutrophils as a model. Several studies have reported cytotoxic effects of NPs but there are limited reports on their potential to perturb the innate immune system of aquatic organisms. PAA-TiO2 significantly decreased neutrophil viability in a time and dose-dependent manner at all measured time points (0–48 h) and concentrations (0–200 µg/mL). Maximum viability decreased by (mean ± SEM): 67.1 ± 3.3%, 78.4 ± 4.2% and 74.9 ± 5.0% when exposed to 50, 100 and 200 µg/mL for 48 h, respectively. PAA-ZnO also significantly decreased neutrophil viability but only at 48 h exposures at higher concentrations. Neutrophil degranulation increased by approximately 3% after 30 min and by 8% after 4 h when exposed to sublethal doses (10 µg/mL) of PAA-CeO2 or PAA-Fe2O3. All PAA-NPs induced an increase in neutrophil respiratory burst when exposed to 10 µg/mL for 30 and 60 min, however, PAA-Fe2O3 was the only NP where the response was significant. Lastly, NPs altered the expression of a number of pro-inflammatory and immune genes, where PAA-TiO2 most significantly increased the mRNA levels of pro-inflammatory genes (il-1b, ifng) in neutrophils by 3 and 2.5 times, respectively. Together, these data demonstrate that goldfish neutrophils can be negatively affected from exposures to PAA-coated NPs and are functionally responsive to specific core-material properties at sublethal doses. These changes could perturb the innate response and affect the ability of fish to respond to pathogens.
Optics Temperature-Dependent Nonuniformity Correction Via  $\ell _{0}$-Regularized Prior for Airborne Infrared Imaging Systems

In this paper, we propose a new ℓ0-regularized approach to remove the temperature-dependent nonuniformity effects induced by the infrared (IR) imaging optics in an aerothermal environment. The ℓ0 image prior is inspired by observing distinct characteristics of IR images with small targets. Based on this effective prior, we present a variational framework where we optimize an energy functional to estimate the optics-related fixed pattern noise (FPN) and the latent image. A computationally efficient numerical algorithm based on half-quadratic regularization is used to solve the optimization problem. The proposed method is fundamentally different from the existing nonuniformity correction techniques developed for infrared focal plane arrays and simultaneously suppresses the optics-related FPN and random noise. Both quantitative and qualitative comparisons to specialized state-of-art algorithms demonstrate its superiority.
Measuring semantic similarity between words using web search engines

Semantic similarity measures play important roles in information retrieval and Natural Language Processing. Previous work in semantic web-related applications such as community mining, relation extraction, automatic meta data extraction have used various semantic similarity measures. Despite the usefulness of semantic similarity measures in these applications, robustly measuring semantic similarity between two words (or entities) remains a challenging task. We propose a robust semantic similarity measure that uses the information available on the Web to measure similarity between words or entities. The proposed method exploits page counts and text snippets returned by a Web search engine. We deflne various similarity scores for two given words P and Q, using the page counts for the queries P, Q and P AND Q. Moreover, we propose a novel approach to compute semantic similarity using automatically extracted lexico-syntactic patterns from text snippets. These difierent similarity scores are integrated using support vector machines, to leverage a robust semantic similarity measure. Experimental results on Miller-Charles benchmark dataset show that the proposed measure outperforms all the existing web-based semantic similarity measures by a wide margin, achieving a correlation coe‐cient of 0:834. Moreover, the proposed semantic similarity measure signiflcantly improves the accuracy (F-measure of 0:78) in a community mining task, and in an entity disambiguation task, thereby verifying the capability of the proposed measure to capture semantic similarity using web content.
Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity

Alzheimer's disease is an age-related neurodegenerative disorder with its toxicity linked to the generation of amyloid-β peptide (Aβ). Within the Aβ sequence, there is a systemic repeat of a GxxxG motif, which theoretical studies have suggested may be involved in both peptide aggregation and membrane perturbation, processes that have been implicated in Aβ toxicity. We synthesized modified Aβ peptides, substituting glycine for leucine residues within the GxxxG repeat motif (GSL peptides). These GSL peptides undergo β-sheet and fibril formation at an increased rate compared with wild-type Aβ. The accelerated rate of amyloid fibril formation resulted in a decrease in the presence of small soluble oligomers such as dimeric and trimeric forms of Aβ in solution, as detected by mass spectrometry. This reduction in the presence of small soluble oligomers resulted in reduced binding to lipid membranes and attenuated toxicity for the GSL peptides. The potential role that dimer and trimer species binding to lipid plays in Aβ toxicity was further highlighted when it was observed that annexin V, a protein that inhibits Aβ toxicity, specifically inhibited Aβ dimers from binding to lipid membranes.
Realizing Smiles: Options Pricing with Realized Volatility

We develop a discrete-time stochastic volatility option pricing model exploiting the information contained in the Realized Volatility (RV), which is used as a proxy of the unobservable log-return volatility. We model the RV dynamics by a simple and effective long-memory process, whose parameters can be easily estimated using historical data. Assuming an exponentially affine stochastic discount factor, we obtain a fully analytic change of measure. An empirical analysis of Standard and Poor's 500 index options illustrates that our model outperforms competing time-varying and stochastic volatility option pricing models.
Predictive factors for nonalcoholic steatohepatitis (NASH) in patients with nonalcoholic fatty liver disease (NAFLD).

AIMS The aim of our study was to assess the clinical and biological parameters associated with Nonalcoholic steatohepatitis (NASH) and to establish the predictors of significant fibrosis in Nonalcoholic fatty liver disease (NAFLD) patients. METHODS We correlated clinical and biochemical parameters with histological features (simple steatosis or steatohepatitis) in 97 patients with NAFLD admitted to the University Hospital Bucharest for persistently raised aminotransferase levels. The biochemical parameters included lipid profile, glucose, liver tests and insulin. The Homeostatic Metabolic Assesment (HOMA)-index and the oxidative stress were also evaluated. Factors associated with NASH and severe fibrosis (F≥=3) were identified using the Mann-Whitney U test and multivariate analysis. The overall validity was measured using the area under receiver operating characteristic curve (AUROC) with 95% CI. RESULTS At univariate analysis, age, BMI, splenic longitudinal diameter (SLD), HOMA, gamma glutamyl transpeptidase, C- reactive protein (CRP), albumin and INR were significantly associated with histologically proven NASH. The multivariate analysis identified four independent predictive factors for the presence of NASH: CRP (p=0.004), SLD (p=0.018), HOMA (p=0.03) and albumin level (p=0.041). The variables independently associated with severe fibrosis were albumin (p=0.008), blood glucose (p=0.017) and BMI (p=0.048). CONCLUSION A predictive model that incorporates the clinical and biological parameters may identify at-risk patients with NAFLD, avoiding liver biopsy on a routine basis.
Cytochrome P450 Inhibitors Reduce Creeping Bentgrass (Agrostis stolonifera) Tolerance to Topramezone

Creeping bentgrass (Agrostis stolonifera L.) is moderately tolerant to the p-hydroxyphenylpyruvate dioxygenase-inhibiting herbicide topramezone. However, the contribution of plant metabolism of topramezone to this tolerance is unknown. Experiments were conducted to determine if known cytochrome P450 monooxygenase inhibitors 1-aminobenzotriazole (ABT) and malathion alone or in combination with the herbicide safener cloquintocet-mexyl influence creeping bentgrass tolerance to topramezone. Creeping bentgrass in hydroponic culture was treated with ABT (70 μM), malathion (70 μm and 1000 g ha-1), or cloquintocet-mexyl (70 μM and 1000 g ha-1) prior to topramezone (8 g ha-1) application. Topramezone-induced injury to creeping bentgrass increased from 22% when applied alone to 79 and 41% when applied with malathion or ABT, respectively. Cloquintocet-mexyl (70 μM and 1000 g ha-1) reduced topramezone injury to 1% and increased creeping bentgrass biomass and PSII quantum yield. Cloquintocet-mexyl mitigated the synergistic effects of ABT more than those of malathion. The effects of malathion on topramezone injury were supported by creeping bentgrass biomass responses. Responses to ABT and malathion suggest that creeping bentgrass tolerance to topramezone is influenced by cytochrome P450-catalyzed metabolism. Future research should elucidate primary topramezone metabolites and determine the contribution of cytochrome P450 monooxygenases and glutathione S-transferases to metabolite formation in safened and non-safened creeping bentgrass.
Actin Filaments Facilitate Insulin Activation of the Src and Collagen Homologous/Mitogen-activated Protein Kinase Pathway Leading to DNA Synthesis and c-fos Expression*

The exact mechanism of the spatial organization of the insulin signaling pathway leading to nuclear events remains unknown. Here, we investigated the involvement of the actin cytoskeleton in propagation of insulin signaling events leading to DNA synthesis and expression of the immediate early genes c-fosand c-jun in L6 muscle cells. Insulin reorganized the cellular actin network and increased the rate of DNA synthesis and the levels of c-fos mRNA, but not those of c-jun mRNA, in undifferentiated L6 myoblasts. Similarly, insulin markedly elevated the levels of c-fos mRNA but not of c-jun mRNA in differentiated L6 myotubes. Disassembly of the actin filaments by cytochalasin D, latrunculin B, or botulinum C2 toxin significantly inhibited insulin-mediated DNA synthesis in myoblasts and abolished stimulation of c-fos expression by the hormone in myoblasts and myotubes. Actin disassembly abolished insulin-induced phosphorylation and activation of extracellulor signal-regulated kinases, activation of a 65-kda member of the p21-activated kinases, and phosphorylation of p38 mitogen-activated protein kinases but did not prevent activation of phosphatidylinositol 3-kinase and p70S6k. Under these conditions, insulin-induced Ras activation was also abolished, and Grb2 association with the Src and collogen homologous (Shc) molecule was inhibited without inhibition of the tyrosine phosphorylation of Shc. We conclude that the actin filament network plays an essential role in insulin regulation of Shc-dependent signaling events governing gene expression by facilitating the interaction of Shc with Grb2.
Hospital nurse practice environments and outcomes for surgical oncology patients.

OBJECTIVE To examine the effect of nursing practice environments on outcomes of hospitalized cancer patients undergoing surgery. DATA SOURCES Secondary analysis of cancer registry, inpatient claims, administrative and nurse survey data collected in Pennsylvania for 1998-1999. STUDY DESIGN Nurse staffing (patient to nurse ratio), educational preparation (proportion of nurses holding at least a bachelor's degree), and the practice environment (Practice Environment Scale of the Nursing Work Index) were calculated from a survey of nurses and aggregated to the hospital level. Logistic regression models predicted the odds of 30-day mortality, complications, and failure to rescue (death following a complication). PRINCIPAL FINDINGS Unadjusted death, complication, and failure to rescue rates were 3.4, 35.7, and 9.3 percent, respectively. Nurse staffing and educational preparation of registered nurses were significantly associated with patient outcomes. After adjusting for patient and hospital characteristics, patients in hospitals with poor nurse practice environments had significantly increased odds of death (odds ratio, 1.37; 95 percent confidence interval, 1.07-1.76) and of failure to rescue (odds ratio, 1.48; 95 percent confidence interval, 1.07-2.03). Receipt of care in National Cancer Institute-designated cancer centers significantly decreased the odds of death, which can be explained partly by better nurse practice environments. CONCLUSIONS This study is one of the first to examine the predictive validity of the National Quality Forum's endorsed measure of the nurse practice environment. Improvements in the quality of nurse practice environments could reduce adverse outcomes for hospitalized surgical oncology patients.
Peritonsillar abscess or cellulitis? A clinical comparative paediatric study.

OBJECTIVE Peritonsillar sepsis (PTS) can be divided into abscess and cellulitis. It is the most common deep neck infection in the paediatric age group. In this article we discuss the clinical issues related to peritonsillar sepsis in children. METHOD This study involves 185 cases of peritonsillar that were treated at the Montreal Children's Hospital in the last 10 years. The symptoms, signs, laboratory and radiological data as well as the medical and surgical therapies are included. RESULTS Seventy-five cases were peritonsillar cellulitis (PTC) and the rest were abscesses. The age at presentation varied between 2.5 months and 18 years. The majority of the cases diagnosed as peritonsillar abscess (PTA) occurred from age 12 to 18 years. Trismus was the only complaint that was statistically associated with PTA. Uvular deviation combined with trismus was also important in differentiating PTA from PTC. Our data revealed a lower percentage of anaerobic bacteria and the majority of cultures grew Streptococcus pyogenes group A. CONCLUSIONS Clinical picture is important in differentiating PTA from PTC. Recurrence of peritonsillar sepsis was higher in children with a history of recurrent tonsillitis. Needle aspiration of PTA resulted in a higher incidence of recurrence compared to incision and drainage. A management algorithm is suggested for the child presenting with peritonsillar sepsis.
MultiEXCELL: A new rainfall model for the analysis of the millimetre wave propagation through the atmosphere

Telecommunication systems which operate at frequencies in the Ka and Q/V bands have to cope with extremely strong tropospheric propagation impairments, mainly caused by rain, which require the application of Fade Mitigation Techniques (FMTs) in order to guarantee the desired system availability. This paper presents MultiEXCELL, a new global model for the generation of realistic synthetic rain fields, particularly suitable for the analysis of issues related to the radio propagation in the atmosphere. The potentialities of the MultiEXCELL model are illustrated by simulating a two-station site diversity telecommunication system and by evaluating the advantages deriving from the implementation of such a fade mitigation technique.
The Luminosity Function of Galaxies in the Las Campanas Redshift Survey

We present the $R$-band luminosity function for a sample of 18678 galaxies, with average redshift $z = 0.1$, from the Las Campanas Redshift Survey. The luminosity function may be fit by a Schechter function with $M^* = -20.29 \pm 0.02 + 5 \log h$, $\alpha = -0.70 \pm 0.05$, and $\phi^* = 0.019 \pm 0.001 \ h^3$~Mpc$^{-3}$, for absolute magnitudes $-23.0 \leq M - 5 \log h \leq -17.5$. We compare our luminosity function to that from other redshift surveys; in particular our normalization is consistent with that of the Stromlo-APM survey, and is therefore a factor of two below that implied by the $b_J \approx 20$ bright galaxy counts. Our normalization thus indicates that much more evolution is needed to match the faint galaxy count data, compared to minimal evolution models which normalize at $b_J \approx 20$. Also, we show that our faint-end slope $\alpha = -0.7$, though ``shallower'' than typical previous values $\alpha = -1$, results primarily from fitting the detailed shape of the LCRS luminosity function, rather than from any absence of intrinsically faint galaxies from our survey. Finally, using [OII] 3727 equivalent width $W_{\lambda} = 5$~\AA \ as the dividing line, we find significant differences in the luminosity functions of emission and non-emission galaxies, particularly in their $\alpha$ values. Emission galaxies have Schechter parameters $M^* = -20.03 \pm 0.03 + 5 \log h$ and $\alpha = -0.9 \pm 0.1$, while non-emission galaxies are described by $M^* = -20.22 \pm 0.02 + 5 \log h$ and $\alpha = -0.3 \pm 0.1$. (abridged abstract)
Deliberation Networks: Sequence Generation Beyond One-Pass Decoding

The encoder-decoder framework has achieved promising progress for many sequence generation tasks, including machine translation, text summarization, dialog system, image captioning, etc. Such a framework adopts an one-pass forward process while decoding and generating a sequence, but lacks the deliberation process: A generated sequence is directly used as final output without further polishing. However, deliberation is a common behavior in human's daily life like reading news and writing papers/articles/books. In this work, we introduce the deliberation process into the encoder-decoder framework and propose deliberation networks for sequence generation. A deliberation network has two levels of decoders, where the first-pass decoder generates a raw sequence and the second-pass decoder polishes and refines the raw sentence with deliberation. Since the second-pass deliberation decoder has global information about what the sequence to be generated might be, it has the potential to generate a better sequence by looking into future words in the raw sentence. Experiments on neural machine translation and text summarization demonstrate the effectiveness of the proposed deliberation networks. On the WMT 2014 English-to-French translation task, our model establishes a new state-of-the-art BLEU score of 41.5.