Miracle-dz/UniFAR-FTUs huggingface dataset:
Electroacupuncture at the Zusanli and Baihui acupoints ameliorates type-2 diabetes-induced reductions in proliferating cells and differentiated neuroblasts in the hippocampal dentate gyrus with increasing brain-derived neurotrophic factor levels

In the current study, we investigated whether electroacupuncture (EA) can inhibit pathological reductions in neurogenesis. Zucker diabetic fatty (ZDF) rats at 7 weeks of age were anesthetized with zoletil, and sham-acupuncture or EA at the Zusanli (ST36) and Baihui (GV20) acupoints was administered once a day for 5 weeks. In the ZDF group that received sham-EA (ZDF-Sham group), the blood glucose level was significantly increased together with age as compared to the control littermates [Zucker lean control (ZLC) rat]. In contrast, proliferating cells and differentiated neuroblasts were significantly decreased in the ZDF-Sham group compared to the ZLC group. Although EA treatment decreased blood glucose levels, this was not statistically significant when compared to blood glucose levels changes in the ZDF-Sham group. However, proliferating cells and differentiated neuroblasts were significantly increased with EA in ZDF rats as compared to those in the ZDF-Sham group. Brain-derived neurotrophic factor (BDNF) levels were significantly decreased in hippocampal homogenates of ZDF-Sham group compared to those in the ZLC group. The EA treatment significantly increased the BDNF levels compared to those in the ZDF-Sham group, and BDNF levels in this group were similar to those in the ZLC group. These results suggest that EA at ST36 and GV20 can ameliorate the reductions in proliferating cells and differentiated neuroblasts in the dentate gyrus induced by type-2 diabetes without significantly reducing blood glucose levels with increasing BDNF levels.
The pre-university pathways of disadvantaged students for gaining entry to university study

This article focuses on the pre-university access pathways of disadvantaged first-generation students studying at a South African university. Based on data collected via qualitative methods, it draws on findings from a study of purposively selected students at a university in the Western Cape Province. It explores the ways they access and gain admission to the university. Combining Bourdieu’s (2006) notion of ‘cultural capital’ with Yosso’s (2005) notion of ‘community cultural wealth’, the article attempts to understand how these students use the resources in their families and communities to gain entry to the university. The article shows the decisive role that family capital and productive township networks play in the students’ university admission pathways. Their ability to navigate around the ‘darker’ aspects of their impoverished communities and establish peer and community support networks is crucial in making their desire for university study a reality. The article illustrates the longer and circuitous admission routes that they take to gain university entry, one key consequence of which is that they adjust their aspirations to settle for less prestigious university programmes. Settling for programmes of ‘lower’ prestige was a way of securing admission to the university.
The positive mass and isoperimetric inequalities for axisymmetric black holes in four and five dimensions

In this paper, we revisit Brill's proof of positive mass for three-dimensional, time-symmetric, axisymmetric initial data and generalize his argument in various directions. In 3 + 1 dimensions, we include an apparent horizon in the initial data and prove the Riemannian Penrose inequality in a wide number of cases by an elementary argument. In the case of 4 + 1 dimensions, we obtain the analogue of Brill's formula for initial data admitting a generalized form of axisymmetry. Including an apparent horizon in the initial data, the Riemannian Penrose inequality is again proved for a large class of cases. The results may have applications in numerical relativity.
The Political Economy of Social Security

We consider a two-period overlapping generations model in which individual voters differ not only according to age but also productivity. In such a setting, a (redistributive) Pay-As-You-Go system is politically sustainable, even when the interest rate is larger than the rate of population growth. The medium wages workers (not the lowest) join the retirees to form a majority and vote for a positive level of social security. This level depends on the difference between population growth and interest rate and on the redistributiveness of the benefit rule.
Relative Risk of Visceral Leishmaniasis in Brazil: A Spatial Analysis in Urban Area

Background Visceral leishmaniasis (VL) is a vector-borne disease whose factors involved in transmission are poorly understood, especially in more urban and densely populated counties. In Brazil, the VL urbanization is a challenge for the control program. The goals were to identify the greater risk areas for human VL and the risk factors involved in transmission. Methodology This is an ecological study on the relative risk of human VL. Spatial units of analysis were the coverage areas of the Basic Health Units (146 small-areas) of Belo Horizonte, Minas Gerais State, Brazil. Human VL cases, from 2007 to 2009 (n = 412), were obtained in the Brazilian Reportable Disease Information System. Bayesian approach was used to model the relative risk of VL including potential risk factors involved in transmission (canine infection, socioeconomic and environmental features) and to identify the small-areas of greater risk to human VL. Principal Findings The relative risk of VL was shown to be correlated with income, education, and the number of infected dogs per inhabitants. The estimates of relative risk of VL were higher than 1.0 in 54% of the areas (79/146). The spatial modeling highlighted 14 areas with the highest relative risk of VL and 12 of them are concentrated in the northern region of the city. Conclusions The spatial analysis used in this study is useful for the identification of small-areas according to risk of human VL and presents operational applicability in control and surveillance program in an urban environment with an unequal spatial distribution of the disease. Thus the frequent monitoring of relative risk of human VL in small-areas is important to direct and prioritize the actions of the control program in urban environment, especially in big cities.
Morphological Reconstruction Operation for the Detection of Defects in Woven Fabric

Basic morphological processing i.e. erosion and dilation, often fails to detect various types of defects that may be present in woven fabric, mainly because of the presence of interlaced grating structure of the weft and warp of the fabric. In this paper basic grating structure is optically filtered and then gray scale morphological reconstruction operations are applied for the detection of defects. The results have shown the usefulness of the proposed method during detections of various types of defects in woven fabric, as illustrated by the portions given in this document.
The Degradation Interface of Magnesium Based Alloys in Direct Contact with Human Primary Osteoblast Cells

Magnesium alloys have been identified as a new generation material of orthopaedic implants. In vitro setups mimicking physiological conditions are promising for material / degradation analysis prior to in vivo studies however the direct influence of cell on the degradation mechanism has never been investigated. For the first time, the direct, active, influence of human primary osteoblasts on magnesium-based materials (pure magnesium, Mg-2Ag and Mg-10Gd alloys) is studied for up to 14 days. Several parameters such as composition of the degradation interface (directly beneath the cells) are analysed with a scanning electron microscope equipped with energy dispersive X-ray and focused ion beam. Furthermore, influence of the materials on cell metabolism is examined via different parameters like active mineralisation process. The results are highlighting the influences of the selected alloying element on the initial cells metabolic activity.
HUMAN CAPITAL INVESTMENT AND LONG‐TERM POVERTY REDUCTION IN RURAL MEXICO

By focussing on human capital investment, the Mexican Oportunidades program will influence the economic choices of the rural poor. To understand how beneficiaries may alter their behaviour as a result of this intervention, this paper uses administrative data to analyse the economic activities of the rural poor. Results indicate that investments in education are likely to shift recipients from agricultural wage employment towards non-farm wage employment. The magnitude of this impact will be influenced by household assets and by the location of the household. The results suggest the need for policies that complement the government's focus on human capital investment. Copyright © 2010 John Wiley & Sons, Ltd.
Anomalies: The Law of One Price in Financial Markets

The Law of One price states that identical goods (or securities) should sell for identical prices. In financial markets the law of one price is thought to hold almost exactly, and is the basis for much of financial economic theory. We present evidence on several examples of violations of this law, including closed-end country funds, twin shares, dual class shares, and corporate spinoffs. We analyze the causes of these violations, and show they all stem from some limits on the extent to which rational arbitrageurs can intervene.
THE Rh BLOOD GROUP SYSTEM

T he Rh blood group system is one of the most polymorphic and antigenic blood group systems. It is second only to ABO in importance in blood transfusion and is well known as a primary cause of hemolytic disease of the fetus and newborn (HDFN). The principal antigen is D, and the terms Rh positive and Rh negative refer to the presence or absence of D antigen. Caucasians of European extraction have the highest incidence of the Rh-negative phenotype (15% to 17%), and Rh-negative type is much less common in Africa (5%) and Australia and is considered a rare blood type not routinely tested for in some parts of Asia ( 1%). Other common Rh antigens include the antithetical C and c, and E and e antigens. Patients are not routinely typed for these unless they have developed atypical antibodies or are facing long-term transfusion support for diseases such as myelodysplasia or sickle cell disease (SCD). In addition to the five principal antigens (D, C, c, E, and e), more than 50 other Rh system antigens are known. Because they are not often encountered in the routine blood bank, they will not be covered here in detail. References at the end of the chapter provide further information for interested readers.
Distinct striatal regions support movement selection, preparation and execution

The aim of this study was to determine whether distinct striatal territories are specifically involved during the selection, preparation and execution of a movement. Nine volunteers were studied using fMRI at 3 T. Subjects were presented with visual stimuli instructing them to prepare during a variable delay and then execute a button press with either the left or the right hand. The side of the movement was either freely selected by the subject (free selection) or specified by the instruction cue (preparation). Movement selection, preparation and execution were associated with activation in the caudate nucleus, the anterior and the posterior parts of the putamen, respectively. These results suggest that these three aspects of movement are represented within distinct basal ganglia regions.
Income Disparity and Risk of Death: The Importance of Health Behaviors and Other Mediating Factors

Background Income disparities in mortality are profound in the United States, but reasons for this remain largely unexplained. The objective of this study was to assess the effects of health behaviors, and other mediating pathways, separately and simultaneously, including health insurance, health status, and inflammation, in the association between income and mortality. Methods This study used data from 9925 individuals aged 20 years or older who participated in the 1999–2004 National Health and Nutrition Examination Survey (NHANES) and were followed up through December 31, 2006 for mortality. The outcome measures were all-cause and CVD/diabetes mortality. During follow-up 505 persons died, including 196 deaths due to CVD or diabetes. Results After adjusting for age, sex, education, and race/ethnicity, risk of death was higher in low-income than high-income group for both all-cause mortality (Hazard ratio [HR], 1.98; 95% confidence interval [CI]: 1.37, 2.85) and cardiovascular disease (CVD)/diabetes mortality (HR, 3.68; 95% CI: 1.64, 8.27). The combination of the four pathways attenuated 58% of the association between income and all-cause mortality and 35% of that of CVD/diabetes mortality. Health behaviors attenuated the risk of all-cause and CVD/diabetes mortality by 30% and 21%, respectively, in the low-income group. Health status attenuated 39% of all-cause mortality and 18% of CVD/diabetes mortality, whereas, health insurance and inflammation accounted for only a small portion of the income-associated mortality (≤6%). Conclusion Excess mortality associated with lower income can be largely accounted for by poor health status and unhealthy behaviors. Future studies should address behavioral modification, as well as possible strategies to improve health status in low-income people.
Inflammation in Atherosclerosis: Visualizing Matrix Metalloproteinase Action in Macrophages In Vivo

Background— Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications. Methods and Results— To test the hypothesis that optical molecular imaging with the use of an activatable near-infrared fluorescence (NIRF) probe can detect enzymatic action of MMP in atherosclerotic plaques, we used a NIRF substrate for gelatinases (MMP-2/gelatinase-A and MMP-9/gelatinase-B) in apolipoprotein E–deficient (apoE−/−) mice that consumed a high-cholesterol diet for 12 weeks and age-matched apoE+/+ mice as control. The aortas of apoE−/− mice at 24 hours after probe yielded intense NIRF signals, as detected by NIRF reflectance ex vivo, compared with negligible signals in aortas of apoE+/+ mice with/without probe administration or atherosclerotic apoE−/− aortas without probe. Gelatinase inhibitor treatment abolished NIRF signals in apoE−/− mouse aortas ex vivo. Sites of gelatinase activity visualized by NIRF colocalized with macrophage accumulation, immunoreactive MMP-2 and MMP-9, and gelatinolytic activity detected by in situ zymography. Furthermore, fluorescence molecular tomography indicated in vivo that atherosclerotic aortas of apoE−/− mice produced NIRF signals for gelatinase action, whereas aortas of apoE+/+ mice injected with the probe or apoE−/− aortas with no probe exhibited negligible NIRF signals. Conclusions— These results suggest the feasibility of noninvasively imaging the enzymatic action of MMPs in vivo, an approach that may gauge inflammatory foci in atherosclerosis, assess cardiovascular risk, and evaluate the effects of therapeutic interventions.
Cloning and Expression of a Complementary DNA Encoding a Molluscan Octopamine Receptor That Couples to Chloride Channels in HEK293 Cells*

A cDNA encoding a G-protein-coupled receptor was cloned from the central nervous system of the pond snail Lymnaea stagnalis The predicted amino acid sequence of this cDNA most closely resembles the Drosophila tyramine/octopamine receptor, the Locusta tyramine receptor, and an octopamine receptor (Lym oa1) that we recently cloned from Lymnaea After stable expression of the cDNA in HEK293 cells, we found that [3H]rauwolscine binds with high affinity to the receptor (KD = 6.2·10−9 M). Octopamine appears to be the most potent naturally occurring agonist to displace the [3H]rauwolscine binding (Ki = 3.0·10−7 M). Therefore, the receptor is considered to be an octopamine receptor and is consequently designated Lym oa2. The novel receptor shares little pharmacological resemblance with Lym oa1, indicating that the two receptors represent different octopamine receptor subfamilies. Octopaminergic stimulation of Lym oa2 does not induce changes in intracellular concentrations of cAMP or inositol phosphates. However, electrophysiological experiments indicate that octopamine is able to activate a voltage-independent Cl− current in HEK293 cells stably expressing Lym oa2. Although opening of this chloride channel most probably does not require the activation of either protein kinase A or C, it can be blocked by inhibition of protein phosphorylation.
The White Dwarf Distance to the Globular Cluster 47 Tucanae and its Age

We present a new determination of the distance (and age) of the Galactic globular cluster 47 Tucanae (NGC 104) based on the fit of its white dwarf (WD) cooling sequence with the empirical fiducial sequence of local WD with known trigonometric parallax, following the method described by Renzini and collaborators. Both the cluster and the local WDs were imaged with HST WFPC2 using the same instrument setup. We obtain an apparent distance modulus of (m-M)V = 13.27 ± 0.14, consistent with previous ground-based determinations and shorter than that found using Hipparcos subdwarfs. Coupling our distance determination with a new measure of the apparent magnitude of the main-sequence turnoff based on our HST data, we derive an age of 13 ± 2.5 Gyr.
Schema Management for Document Stores

Document stores that provide the efficiency of a schema-less interface are widely used by developers in mobile and cloud applications. However, the simplicity developers achieved controversially leads to complexity for data management due to lack of a schema. In this paper, we present a schema management framework for document stores. This framework discovers and persists schemas of JSON records in a repository, and also supports queries and schema summarization. The major technical challenge comes from varied structures of records caused by the schema-less data model and schema evolution. In the discovery phase, we apply a canonical form based method and propose an algorithm based on equivalent sub-trees to group equivalent schemas efficiently. Together with the algorithm, we propose a new data structure, eSiBu-Tree, to store schemas and support queries. In order to present a single summarized representation for heterogenous schemas in records, we introduce the concept of "skeleton", and propose to use it as a relaxed form of the schema, which captures a small set of core attributes. Finally, extensive experiments based on real data sets demonstrate the efficiency of our proposed schema discovery algorithms, and practical use cases in real-world data exploration and integration scenarios are presented to illustrate the effectiveness of using skeletons in these applications.
Development and Evaluation of the Brief Sexual Openness Scale—A Construal Level Theory Based Approach

Obtaining reliable and valid data on sensitive questions represents a longstanding challenge for public health, particularly HIV research. To overcome the challenge, we assessed a construal level theory (CLT)-based novel method. The method was previously established and pilot-tested using the Brief Sexual Openness Scale (BSOS). This scale consists of five items assessing attitudes toward premarital sex, multiple sexual partners, homosexuality, extramarital sex, and commercial sex, all rated on a standard 5-point Likert scale. In addition to self-assessment, the participants were asked to assess rural residents, urban residents, and foreigners. The self-assessment plus the assessment of the three other groups were all used as subconstructs of one latent construct: sexual openness. The method was validated with data from 1,132 rural-to-urban migrants (mean age = 32.5, SD = 7.9; 49.6% female) recruited in China. Consistent with CLT, the Cronbach alpha of the BSOS as a conventional tool increased with social distance, from . 81 for self-assessment to . 97 for assessing foreigners. In addition to a satisfactory fit of the data to a one-factor model (CFI = .94, TLI = .93, RMSEA = .08), a common factor was separated from the four perspective factors (i.e., migrants’ self-perspective and their perspectives of rural residents, urban residents and foreigners) through a trifactor modeling analysis (CFI = .95, TLI = .94, RMSEA = .08). Relative to its conventional form, CTL-based BSOS was more reliable (alpha: .96 vs .81) and valid in predicting sexual desire, frequency of dating, age of first sex, multiple sexual partners and STD history. This novel technique can be used to assess sexual openness, and possibly other sensitive questions among Chinese domestic migrants.
Crash-Neutral Currency Carry Trades

Currency carry trades exploiting violations of uncovered interest rate parity in G10 currencies deliver significant excess returns with annualized Sharpe ratios equal to or greater than those of equity market factors (1990–2012). Using data on out-of-the-money foreign exchange options, I compute returns to crash-hedged portfolios and demonstrate that the high returns to carry trades are not due to peso problems. A comparison of the returns to hedged and unhedged trades indicates crash risk premia account for at most one-third of the excess return to currency carry trades.
SOME SUFFICIENT CONDITIONS FOR UNIVALENCE AND STARLIKENESS

The object of the present paper is to derive certain sufficient conditions for univalence, p-valently starlikeness and p-valently close-to-convexity of analytic functions in the unit disk. Our results extend and improve some results due to Owa (3), Frasin and Darus (2) and Chen (1).
Attention Sharpens the Distinction between Expected and Unexpected Percepts in the Visual Brain

Attention, the prioritization of goal-relevant stimuli, and expectation, the modulation of stimulus processing by probabilistic context, represent the two main endogenous determinants of visual cognition. Neural selectivity in visual cortex is enhanced for both attended and expected stimuli, but the functional relationship between these mechanisms is poorly understood. Here, we adjudicated between two current hypotheses of how attention relates to predictive processing, namely, that attention either enhances or filters out perceptual prediction errors (PEs), the PE-promotion model versus the PE-suppression model. We acquired fMRI data from category-selective visual regions while human subjects viewed expected and unexpected stimuli that were either attended or unattended. Then, we trained multivariate neural pattern classifiers to discriminate expected from unexpected stimuli, depending on whether these stimuli had been attended or unattended. If attention promotes PEs, then this should increase the disparity of neural patterns associated with expected and unexpected stimuli, thus enhancing the classifier's ability to distinguish between the two. In contrast, if attention suppresses PEs, then this should reduce the disparity between neural signals for expected and unexpected percepts, thus impairing classifier performance. We demonstrate that attention greatly enhances a neural pattern classifier's ability to discriminate between expected and unexpected stimuli in a region- and stimulus category-specific fashion. These findings are incompatible with the PE-suppression model, but they strongly support the PE-promotion model, whereby attention increases the precision of prediction errors. Our results clarify the relationship between attention and expectation, casting attention as a mechanism for accelerating online error correction in predicting task-relevant visual inputs.