Miracle-dz/UniFAR-FTUs huggingface dataset:
The serum vitamin D level is inversely correlated with nonalcoholic fatty liver disease

Background/Aims: A low vitamin D level has been associated with metabolic syndrome and diabetes. However, an association between a low vitamin D level and nonalcoholic fatty liver disease (NAFLD) has not yet been definitively established. This study aimed to characterize the relationship between a vitamin D level and NAFLD in Korea. Methods: A cross-sectional study involving 6,055 health check-up subjects was conducted. NAFLD was diagnosed on the basis of typical ultrasonographic findings and a history of alcohol consumption. Results: The subjects were aged 51.7±10.3 years (mean±SD) and 54.7% were female. NAFLD showed a significant inverse correlation with the vitamin D level after adjusting for age and sex [odds ratio (OR)=0.85, 95% confidence interval (CI)=0.75–0.96]. The age- and sex-adjusted prevalence of NAFLD decreased steadily with increasing vitamin D level [OR=0.74, 95% CI=0.60–0.90, lowest quintile (≤14.4 ng/mL) vs highest quintile (≥28.9 ng/mL), p for trend <0.001]. Multivariate regression analysis after adjusting for other metabolic factors revealed that NAFLD showed a significant inverse correlation with both the vitamin D level (>20 ng/mL) [OR=0.86, 95% CI=0.75-0.99] and the quintiles of the vitamin D level in a dose-dependent manner (p for trend=0.001). Conclusions: The serum level of vitamin D, even when within the normal range, was found to be inversely correlated with NAFLD in a dose-dependent manner. Vitamin D was found to be inversely correlated with NAFLD independent of known metabolic risk factors. These findings suggest that vitamin D exerts protective effects against NAFLD.
Phasmomantella gen. nov., a spectacular new genus of praying mantis from southern Central Vietnam (Mantodea, Mantidae, Deroplatyinae, Euchomenellini)

The new genus Phasmomantella gen. nov. is created to accommodate the new species P. nuichuana gen. et sp. nov. described from five adult females from Núi Chúa National Park in southern Central Vietnam. A second species, Phasmomantella pallida (Roy, 2001) gen. et comb. nov., is transferred from Euchomenella where it was originally described based on a single male specimen from the Nha Trang region in the Khánh Hòa Province. Phasmomantella gen. nov. is placed in the tribe Euchomenellini of the subfamily Deroplatyinae. A comprehensive diagnosis and detailed descriptions are presented along with high-resolution photographs, measurements and a distribution map. The standardised measurements are illustrated and a new key is proposed for the tribe Euchomenellini. The unique biogeography and habitats of the collection site within Núi Chúa National Park are discussed in the light of possible endemism and importance for nature conservation.
Analysis and synthesis of hypo- and hyperarticulated speech

This paper focuses on the analysis and synthesis of hypo and hyperarticulated speech in the framework of HMM-based speech synthesis. First of all, a new French database matching our needs was created, which contains three identical sets, pronounced with three different degrees of articulation: neutral, hypo and hyperarticulated speech. On that basis, acoustic and phonetic analyses were performed. It is shown that the degrees of articulation significantly influence, on one hand, both vocal tract and glottal characteristics, and on the other hand, speech rate, phone durations, phone variations and the presence of glottal stops. Finally, neutral, hypo and hyperarticulated speech are synthesized using HMM-based speech synthesis and both objective and subjective tests aiming at assessing the generated speech quality are performed. These tests show that synthesized hypoarticulated speech seems to be less naturally rendered than neutral and hyperarticulated speech.
Ionic currents in single isolated bullfrog atrial cells

Enzymatic dispersion has been used to yield single cells from segments of bullfrog atrium. Previous data (Hume and Giles, 1981) have shown that these individual cells are quiescent and have normal resting potentials and action potentials. The minimum DC space constant is approximately 920 microns. The major goals of the present study were: (a) to develop and refine techniques for making quantitative measurements of the transmembrane ionic currents, and (b) to identify the individual components of ionic current which generate different phases of the action potential. Initial voltage-clamp experiments made using a conventional two-microelectrode technique revealed a small tetrodotoxin (TTX)-insensitive inward current. The small size of this current (2.5-3.0 X 10(-10)A) and the technical difficulty of the two- microelectrode experiments prompted the development of a one- microelectrode voltage-clamp technique which requires impalements using a low-resistance (0.5-2 M omega) micropipette. Voltage-clamp experiments using this new technique in isolated single atrial cells reveal five distinct ionic currents: (a) a conventional transient Na+ current, (b) a TTX-resistant transient inward current, carried mainly by Ca++, (c) a component of persistent inward current, (d) a slowly developing outward K+ current, and (e) an inwardly rectifying time- independent background current. The single suction micropipette technique appears well-suited for use in the quantitative study of ionic currents in these cardiac cells, and in other small cells having similar electrophysiological properties.
Distribution-Specific Hardness of Learning Neural Networks

Although neural networks are routinely and successfully trained in practice using simple gradient-based methods, most existing theoretical results are negative, showing that learning such networks is difficult, in a worst-case sense over all data distributions. In this paper, we take a more nuanced view, and consider whether specific assumptions on the "niceness" of the input distribution, or "niceness" of the target function (e.g. in terms of smoothness, non-degeneracy, incoherence, random choice of parameters etc.), are sufficient to guarantee learnability using gradient-based methods. We provide evidence that neither class of assumptions alone is sufficient: On the one hand, for any member of a class of "nice" target functions, there are difficult input distributions. On the other hand, we identify a family of simple target functions, which are difficult to learn even if the input distribution is "nice". To prove our results, we develop some tools which may be of independent interest, such as extending Fourier-based hardness techniques developed in the context of statistical queries \cite{blum1994weakly}, from the Boolean cube to Euclidean space and to more general classes of functions.
Expressive and flexible access to web-extracted data: a keyword-based structured query language

Automated extraction of structured data from Web sources often leads to large heterogeneous knowledge bases (KB), with data and schema items numbering in the hundreds of thousands or millions. Formulating information needs with conventional structured query languages is difficult due to the sheer size of schema information available to the user. We address this challenge by proposing a new query language that blends keyword search with structured query processing over large information graphs with rich semantics. Our formalism for structured queries based on keywords combines the flexibility of keyword search with the expressiveness of structures queries. We propose a solution to the resulting disambiguation problem caused by introducing keywords as primitives in a structured query language. We show how expressions in our proposed language can be rewritten using the vocabulary of the web-extracted KB, and how different possible rewritings can be ranked based on their syntactic relationship to the keywords in the query as well as their semantic coherence in the underlying KB. An extensive experimental study demonstrates the efficiency and effectiveness of our approach. Additionally, we show how our query language fits into QUICK, an end-to-end information system that integrates web-extracted data graphs with full-text search. In this system, the rewritten query describes an arbitrary topic of interest for which corresponding entities, and documents relevant to the entities, are efficiently retrieved.
Planning foot placements for a humanoid robot: A problem of inverse kinematics

We present a novel approach to plan foot placements for a humanoid robot according to kinematic tasks. In this approach, the foot placements are determined by the continuous deformation of a robot motion including a locomotion phase according to the desired tasks. We propose to represent the motion by a virtual kinematic tree composed of a kinematic model of the robot and articulated foot placements. This representation allows us to formulate the motion deformation problem as a classical inverse kinematics problem on a kinematic tree. We first provide details of the basic scheme where the number of footsteps is given in advance and illustrate it with scenarios on the robot HRP-2. Then we propose a general criterion and an algorithm to adapt the number of footsteps progressively to the kinematic goal. The limits and possible extensions of this approach are discussed last.
A model for promoting physical activity among rural South African adolescent girls

Background In South Africa, the expanding epidemic of non-communicable diseases is partly fuelled by high levels of physical inactivity and sedentary behaviour. Women especially are at high risk, and interventions promoting physical activity are urgently needed for girls in their adolescence, as this is the time when many girls adopt unhealthy lifestyles. Objective This qualitative study aimed to identify and describe facilitating factors and barriers that are associated with physical activity among adolescent girls in rural, north-eastern South Africa and, based on these, to develop a model for promoting leisure-time physical activity within this population. Design The study was conducted in and around three secondary schools. Six focus group discussions were conducted with adolescent girls from the schools, and seven qualitative interviews were held with sports teachers and youth leaders. The data were subjected to thematic analysis. Results Seven thematic areas were identified, each of which was associated with the girls’ self-reported levels of physical activity. The thematic areas are 1) poverty, 2) body image ideals, 3) gender, 4) parents and home life, 5) demographic factors, 6) perceived health effects of physical activity, and 7) human and infrastructural resources. More barriers to physical activity were reported than facilitating factors. Conclusions Analysis of the barriers found in the different themes indicated potential remedial actions that could be taken, and these were synthesised into a model for promoting physical activity among South African adolescent girls in resource-poor environments. The model presents a series of action points, seen both from the ‘supply-side’ perspective (such as the provision of resources and training for the individuals, schools, and organisations which facilitate the activities) and from the ‘demand-side’ perspective (such as the development of empowering messages about body image for teenage girls, and encouraging more parental involvement). The development of physical activity interventions that incorporate this supply- and demand-side model would represent an additional tool for ongoing efforts aimed at tackling the expanding non-communicable disease epidemic in South Africa, and in other resource-constrained settings undergoing rapid health transitions.
In-network Monitoring and Control Policy for DVFS of CMP Networks-on-Chip and Last Level Caches

In chip design today and for a foreseeable future, on-chip communication is not only a performance bottleneck but also a substantial power consumer. This work focuses on employing dynamic voltage and frequency scaling (DVFS) policies for networks-on-chip (NoC) and shared, distributed last-level caches (LLC). In particular, we consider a practical system architecture where the distributed LLC and the NoC share a voltage/frequency domain which is separate from the core domain. This architecture enables controlling the relative speed between the cores and memory hierarchy without introducing synchronization delays within the NoC. DVFS for this architecture is more difficult than individual link/core-based DVFS since it involves spatially distributed monitoring and control. We propose an average memory access time (AMAT)-based monitoring technique and integrate it with DVFS based on PID control theory. Simulations on PARSEC benchmarks yield a 33% dynamic energy savings with a negligible impact on system performance.
Horizons for the Enactive Mind: Values, Social Interaction, and Play

What is the enactive approach to cognition? Over the last 15 years this banner has grown to become a respectable alternative to traditional frameworks in cognitive science. It is at the same time a label with different interpretations and upon which different doubts have been cast. This paper elaborates on the core ideas that define the enactive approach and their implications: autonomy, sensemaking, emergence, embodiment, and experience. These are coherent, radical and very powerful concepts that establish clear methodological guidelines for research. The paper also looks at the problems that arise from taking these ideas seriously. The enactive approach has plenty of room for elaboration in many different areas and many challenges to respond to. In particular, we concentrate on the problems surrounding several theories of value-appraisal and valuegeneration. The enactive view takes the task of understanding meaning and value very seriously and elaborates a proper scientific alternative to reductionist attempts to tackle these issues by functional localization. Another area where the enactive framework can make a significant contribution is social interaction and social undertanding. The legacy of computationalism and methodological individualism is very strong in this field. Enactivism allows us to see embodied social interaction and coordination at many different levels in an integrated manner, from the emergence of autonomous temporal structures that regulate interaction to the generation of socially mediated meaning. Finally, we also present some speculations about how the enactive approach may be the right tool to help us bridge knowledge of concrete embodied and situated practices and higher-level human cognition, thus becoming a serious contender to computationalism in all areas of cognitive science (and not just on low-level sensorimotor cognition). The language offered by the enactive perspective already proves very useful in formulating the problem of human cognition in a tractable manner. These speculations will centre on the role of play as an activity that allows the development of meaning-manipulation skills as well as a further level of autonomous cognitive self, one that is characteristic of human beings. For the enactive view play is seen as re-creation whereas for computationalism fun is a mystery. These discussions will be supported and illustrated with examples from work in evolutionary robotics. The need for synthetic minimal models and their scientific role is a running theme of this paper.
A study to detect HELLP syndrome and partial HELLP syndrome among preeclamptic mothers and their impact on fetomaternal outcome

Objective: The purpose of the study was to detect & evaluate the feto-maternal outcome of HELLP syndrome & partial HELLP syndrome among preeclamptic mothers. Materials and methods: This cross sectional observational study analysed feto-maternal outcome in 44 patients with HELLP syndrome and 32 patients with partial HELLP syndrome and compared with 556 patients having preeclampsia without features of HELLP syndrome. Results: 600 patients were included in this study. The prevalence of HELLP syndrome and partial HELLP syndrome were found to be 7.3% and 5.3% respectively in preeclampsia. The systolic blood pressure, gestational age at admission and during delivery, haematological and biochemical variables, rate of spontaneous vaginal delivery and type of anaesthesia were significantly different in HELLP syndrome and partial HELLP syndrome than in the preeclampsia group. There were statistically significant difference in perinatal outcome like birth weight, intrauterine death, neonatal death, and admission in NICU. Eclampsia was significantly increased in both HELLP syndrome and partial HELLP syndrome. Conclusion: Both HELLP and partial HELLP syndrome must be diagnosed as soon as possible in pregnant or post partum women with preeclampsia. HELLP syndrome is severe than preeclampsia in terms of maternal and perinatal outcome. Partial HELLP syndrome is almost as grave as HELLP syndrome.
The International Nucleotide Sequence Database Collaboration

Under the International Nucleotide Sequence Database Collaboration (INSDC; http://www.insdc.org), globally comprehensive public domain nucleotide sequence is captured, preserved and presented. The partners of this long-standing collaboration work closely together to provide data formats and conventions that enable consistent data submission to their databases and support regular data exchange around the globe. Clearly defined policy and governance in relation to free access to data and relationships with journal publishers have positioned INSDC databases as a key provider of the scientific record and a core foundation for the global bioinformatics data infrastructure. While growth in sequence data volumes comes no longer as a surprise to INSDC partners, the uptake of next-generation sequencing technology by mainstream science that we have witnessed in recent years brings a step-change to growth, necessarily making a clear mark on INSDC strategy. In this article, we introduce the INSDC, outline data growth patterns and comment on the challenges of increased growth.
Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).

BACKGROUND Inflammation has been suggested as a risk factor for the development of atherosclerosis. Recently, some components of the insulin resistance syndrome (IRS) have been related to inflammatory markers. We hypothesized that insulin insensitivity, as directly measured, may be associated with inflammation in nondiabetic subjects. METHODS AND RESULTS We studied the relation of C-reactive protein (CRP), fibrinogen, and white cell count to components of IRS in the nondiabetic population of the Insulin Resistance Atherosclerosis Study (IRAS) (n=1008; age, 40 to 69 years; 33% with impaired glucose tolerance), a multicenter, population-based study. None of the subjects had clinical coronary artery disease. Insulin sensitivity (S(I)) was measured by a frequently sampled intravenous glucose tolerance test, and CRP was measured by a highly sensitive competitive immunoassay. All 3 inflammatory markers were correlated with several components of the IRS. Strong associations were found between CRP and measures of body fat (body mass index, waist circumference), S(I), and fasting insulin and proinsulin (all correlation coefficients >0.3, P<0.0001). The associations were consistent among the 3 ethnic groups of the IRAS. There was a linear increase in CRP levels with an increase in the number of metabolic disorders. Body mass index, systolic blood pressure, and S(I) were related to CRP levels in a multivariate linear regression model. CONCLUSIONS We suggest that chronic subclinical inflammation is part of IRS. CRP, a predictor of cardiovascular events in previous reports, was independently related to S(I). These findings suggest potential benefits of anti-inflammatory or insulin-sensitizing treatment strategies in healthy individuals with features of IRS.
A Strategic Empty Container Logistics Optimization in a Major Shipping Company

In this paper, we present a system that Compania Sud Americana de Vapores (CSAV), one of the world's largest shipping companies, developed to support its decisions for repositioning and stocking empty containers. CSAV's main business is shipping cargo in containers to clients worldwide. It uses a fleet of about 700,000 TEU containers of different types, which are carried by both CSAV-owned and third-party ships. Managing the container fleet is complex; CSAV must make thousands of decisions each day. In particular, imbalances exist among the regions. For example, China often has a deficit of empty containers and is a net importer; Saudi Arabia often has a surplus and is a net exporter. CSAV and researchers from the University of Chile developed the Empty Container Logistics Optimization System (ECO) to manage this imbalance. ECO's multicommodity, multiperiod model manages the repositioning problem, whereas an inventory model determines the safety stock required at each location. CSAV uses safety stock to ensure high service levels despite uncertainties, particularly in the demand for containers. A hybrid forecasting system supports both the inventory and the multicommodity network flow model. Major improvements in data gathering, real-time communications, and automation of data handling were needed as input to the models. A collaborative Web-based optimization framework allows agents from different zones to interact in decision making. The use of ECO led to direct savings of $81 million for CSAV, a reduction in inventory stock of 50 percent, and an increase in container turnover of 60 percent. Moreover, the system helped CSAV to become more efficient and to overcome the 2008 economic crisis.
The Kidney from Prenatal to Adult Life: Perinatal Programming and Reduction of Number of Nephrons during Development

Modified embryonic-fetal development resulting in low birth weight may lead to a reduced nephron endowment, hypertension and renal diseases in adulthood. Regarding the involvement of genetic factors, several environmental conditions may also contribute towards reducing the number of nephrons in the fetus and infant, subsequently constituting a health burden in later life. To date no methods of investigation for the early detection of a reduced nephron reserve are available. However, more structured studies should be implemented to investigate the role of angiotensin-converting enzyme inhibitors in managing proteinurias and glomerulosclerosis in children with renal conditions characterized by reduce nephron number and glomerular hypertrophic changes. In view of the current lack of specific methods of investigation and management, close monitoring of children and young adults at risk of reduced renal reserve should be carried out to enhance the early detection of potential changes in renal function.
Mobile multicast (MoM) protocol: multicast support for mobile hosts

Thii paper describes a new protocol to support IP multicast for mobile hosts in an IP internetwork. It uses the basic unicast routing capability of IETF Mobile IP as a foundation, and leverages existing IP multicast to provide multicast services for mobile hosts as well. We believe that the resulting scheme is simple, scalable, transparent, and to the extent possible, independent of the underlying multicast routing facility. Discrete-event simulation was used as the vehicle for a LLproof of concept” debugging of the protocol, as well as to determine its performance characteristics. A key feature of the new protocol is the use of designated multicast service providers (DMSPs) to address the scalability issues of mobile multicast. Our simulation results suggest distinct performance advantages of our protocol using DMSPs over two other approaches proposed for the mobile multicast problem, namely remote subscription and bi-directional tunnelling, particularly as the number of mobile group members increases.