Miracle-dz/UniFAR-FTUs huggingface dataset:
Three-Dimensional Finite Element Model of the Cervical Spinal Cord: Preliminary Results of Injury Mechanism Analysis

Study Design. A three-dimensional finite element investigation. Objectives. To create a three-dimensional finite element model of the cervical spinal cord enlargement and to simulate a hyperextension injury of the cervical cord. Summary of Background Data. Experimental studies are difficult to simulate the complex mechanism of spinal cord injuries. The introduction of three-dimensional modeling technique into neurotrauma studies is essential to further understand mechanical behavior of the nerve tissue during traumatic injuries. Methods. Geometrical reconstruction of cervical spinal cord enlargement was developed based on the morphologic features of each segment of the fresh human cervical cord. After the validation of the model, the pinching condition in the hyperextension injuries was simulated with compressive and extension forces applied on the cervical enlargement model. The average von Mises stress of the 9 anatomic regions, such as anterior funiculus, lateral part of the lateral funiculus, medial part of the lateral funiculus, lateral part of the posterior funiculus, medial part of the posterior funiculus, anterior horn, the bottom of anterior horn, the apex of posterior horn, the cervix cornu posterioris, and caput cornu posterioris was recorded. Results. The force-displacement response of the spinal cord under compression and axial tension loading was close to the experimental results reported in the literature. The stress distribution of the spinal cord according to the numerical simulation and the morphologic features of the in vivo experiment were also in close agreement. Hyperextension injury simulation showed high localized stress at the anterior and posterior horn in the gray matter. Conclusion. The finite element method as a three-dimensional modeling technique can improve the understanding of the biomechanical behavior of the spinal cord. The results of hyperextension injury simulation of the cervical spinal cord probably account for the predominance of the hand weakness in patients with central cord injury.
INCREASED INCIDENCE OF PEPTIC ULCER DISEASE IN CENTRAL SEROUS CHORIORETINOPATHY PATIENTS: A Population-Based Retrospective Cohort Study

Purpose: To investigate peptic ulcer disease and other possible risk factors in patients with central serous chorioretinopathy (CSR) using a population-based database. Methods: In this population-based retrospective cohort study, longitudinal data from the Taiwan National Health Insurance Research Database were analyzed. The study cohort comprised 835 patients with CSR and the control cohort comprised 4175 patients without CSR from January 2000 to December 2009. Conditional logistic regression was applied to examine the association of peptic ulcer disease and other possible risk factors for CSR, and stratified Cox regression models were applied to examine whether patients with CSR have an increased chance of peptic ulcer disease and hypertension development. Results: The identifiable risk factors for CSR included peptic ulcer disease (adjusted odd ratio: 1.39, P = 0.001) and higher monthly income (adjusted odd ratio: 1.30, P = 0.006). Patients with CSR also had a significantly higher chance of developing peptic ulcer disease after the diagnosis of CSR (adjusted odd ratio: 1.43, P = 0.009). Conclusion: Peptic ulcer disease and higher monthly income are independent risk factors for CSR. Whereas, patients with CSR also had increased risk for peptic ulcer development.
Energy dispatching strategy for micro-grid using hybrid Petri nets model

Autonomous installations supplied by renewable energy sources are usually sized to cover yearly user needs. This involves sometimes an energy deficiency or excess when the need does not meet generation. In case of neighboring autonomous installations, some run into a lack of energy while neighbors provide an energy surplus. Consequently, interconnecting installations via a Micro-Grid should solve the problem. This paper suggests a Hybrid Petri Net (HPN) strategy for micro-grid energy provider in order to make decision on dispatching energy between connected installations. A HPN model combines discrete events (house state) and continuous events (energy flow) to cover the need of some installations by energy surplus offered by neighbours.
Postural Communication of Emotion: Perception of Distinct Poses of Five Discrete Emotions

Emotion can be communicated through multiple distinct modalities. However, an often-ignored channel of communication is posture. Recent research indicates that bodily posture plays an important role in the perception of emotion. However, research examining postural communication of emotion is limited by the variety of validated emotion poses and unknown cohesion of categorical and dimensional ratings. The present study addressed these limitations. Specifically, we examined individuals’ (1) categorization of emotion postures depicting 5 discrete emotions (joy, sadness, fear, anger, and disgust), (2) categorization of different poses depicting the same discrete emotion, and (3) ratings of valence and arousal for each emotion pose. Findings revealed that participants successfully categorized each posture as the target emotion, including disgust. Moreover, participants accurately identified multiple distinct poses within each emotion category. In addition to the categorical responses, dimensional ratings of valence and arousal revealed interesting overlap and distinctions between and within emotion categories. These findings provide the first evidence of an identifiable posture for disgust and instantiate the principle of equifinality of emotional communication through the inclusion of distinct poses within emotion categories. Additionally, the dimensional ratings corroborated the categorical data and provide further granularity for future researchers to consider in examining how distinct emotion poses are perceived.
Pathways of Induction of Peroxiredoxin I Expression in Osteoblasts

Peroxiredoxin I (Prx I) is an oxidative stress-inducible antioxidant protein with thioredoxin peroxidase activity. Here we report that the levels of Prx I mRNA and protein are dramatically increased in a murine osteoblast cell line, MC3T3-E1, by treatment with sodium arsenate. We further studied the signaling pathways that control the induction of Prx I expression. The treatment of osteoblasts with arsenate activated ERK1/2, JNK, and p38 MAPK. Pre-treating cells with inhibitors of p38 MAPK abolished the induction of Prx I protein but had minimal effect on the induction of Prx I mRNA, suggesting that p38 MAPK activity was required for post-transcriptional regulation. The inhibition of ERK1 and ERK2 had no effect on the induction of Prx I expression. Furthermore, rottlerin, an inhibitor of protein kinase Cδ (PKCδ) and calmodulin kinase III, abrogated the up-regulation at both protein and mRNA levels. Staurosporine and Go6983, inhibitors for PKC, also inhibited the induction of Prx I, suggesting that protein kinase Cδ is required for the induction by arsenate. PKCδ was activated by arsenate treatment by in vitro kinase assays. The inhibition of PKCδ by rottlerin did not affect the activation of p38 MAPK by arsenate. These results suggest that there are two separate signaling pathways involved in the up-regulation of Prx I protein in response to arsenate, PKCδ required for transcriptional activation and p38 MAPK required for post-transcriptional regulation.
A Systematic Literature Review and a Unified Model of ATD

Fast software deliveries are hindered by high maintenance efforts due to internal quality issues and Technical Debt (TD) and specifically, Architectural Technical Debt (ATD) has received increased attention in the last few years. ATD has a significant influence and impact on system success and, left unchecked, it can cause expensive repercussions, it is, therefore, of maintenance and evolutionary importance to understand the basic underlying factors of ATD. Thus, with this as background, there is a need for a descriptive model to illustrate and explain the different ATD issues. The aim of this study is to synthesize and compile research efforts with the goal of creating new knowledge with a specific interest in the ATD field. The contribution of this paper is the presentation of a novel descriptive model, providing a comprehensive interpretation of the ATD phenomenon. This model categorizes the main characteristics of ATD and reveals their corresponding relations. The model is based on a systematic literature review (SLR) of currently recognized knowledge concerning ATD.
Oxidation of aliphatic olefins by toluene dioxygenase: enzyme rates and product identification

Toluene dioxygenase from Pseudomonas putida F1 has been studied extensively with aromatic substrates. The present work examined the toluene dioxygenase-catalyzed oxidation of various halogenated ethenes, propenes, butenes and nonhalogenated cis-2-pentene, an isomeric mix of 2-hexenes, cis-2-heptene, and cis-2-octene as substrates for toluene dioxygenase. Enzyme specific activities were determined for the more water-soluble C2 to C5 compounds and ranged from <4 to 52 nmol per min per mg of protein. Trichloroethene was oxidized at a rate of 33 nmol per min per mg of protein. Products from enzyme reactions were identified by gas chromatography-mass spectrometry. Proton and carbon nuclear magnetic resonance spectroscopy of compounds from whole-cell incubation confirmed the identity of products. Substrates lacking a halogen substituent on sp2 carbon atoms were dioxygenated, while those with halogen and one or more unsubstituted allylic methyl groups were monooxygenated to yield allylic alcohols. 2,3-Dichloro-1-propene, containing both a halogenated double bond and a halogenated allylic methyl group, underwent monooxygenation with allylic rearrangement to yield an isomeric mixture of cis- and trans-2,3-dichloro-2-propene-1-ol.
Mood, nicotine, and dose expectancy effects on acute responses to nicotine spray.

INTRODUCTION We recently showed effects of nicotine dose and nicotine expectancy on some responses to cigarette smoking, with generally no influence of induced mood on these effects. The present study extended this line of research to Nicotrol nasal spray, to determine whether formulation (spray vs. smoking) alters responses. METHODS Smokers abstained overnight before each of two virtually identical sessions, involving negative or positive mood induction. They were randomized to one of five groups, four comprising the 2 x 2 balanced placebo design, varying actual and expected dose of nicotine in the nasal spray, and the fifth group a no-spray control. Dependent measures included self-reported affect, craving, withdrawal, and spray ratings of "liking" and "how much nicotine. " Analyses were limited to those whose nicotine expectancies were manipulated successfully (N = 48). RESULTS The following results matched those from our smoking study: expecting nicotine increased liking; expected, but not actual, nicotine dose increased dose perception; neither actual nor expected nicotine dose had much influence on affect or withdrawal; and mood had no influence on these effects. However, both actual and expected nicotine dose decreased craving in response to spray, contrary to our prior study with smoking. DISCUSSION Formulation made little difference in some effects of nicotine and expectancies, but other effects differed by formulation. Some of these findings, particularly for craving reduction, may have implications for enhancing the acute therapeutic effects of nasal spray and, perhaps, other medications in smokers trying to maintain abstinence after quitting.
Mitogenic bovine whey extract modulates matrix metalloproteinase‐2, ‐9, and tissue inhibitor of matrix metalloproteinase‐2 levels in chronic leg ulcers

Matrix metalloproteinases (MMPs) and their tissue inhibitors play important roles in the wound‐healing process. An imbalance in the expression of these molecules is thought to contribute to the failure of chronic ulcers to heal. We investigated whether a mitogenic bovine whey extract enriched with growth factors modulated the expression and activity of MMP‐2 and ‐9, and the tissue inhibitor of MMP‐2 (TIMP‐2) in chronic leg ulcers. Wound fluids and biopsies were collected from chronic leg ulcer patients whose ulcers were treated topically for 4 weeks with placebo or mitogenic bovine whey extract at concentrations of 2.5, 10, and 20 mg/mL. The levels of MMP‐2 and ‐9 in wound fluid samples was assessed by gelatin zymography and showed a decrease in active MMP‐2 in the 2.5 and 10.0 mg/mL mitogenic bovine whey extract‐treated ulcers compared with placebo (p<0.05). Immunohistochemical analysis of ulcer biopsies for MMP‐2, ‐9, and TIMP‐2 expression showed a reduction in the number of MMP‐2–positive dermal fibroblasts in the mitogenic bovine whey extract‐treated ulcers compared with pretreatment biopsies (p<0.05) that persisted over the course of the study. In contrast, a transient increase in the number of MMP‐9– and TIMP‐2–positive cells was observed in mitogenic bovine whey extract treated ulcer biopsies compared with pretreatment levels (p<0.05). These results show that topical application of mitogenic bovine whey extract was able to modulate the expression of MMP‐2, ‐9, and TIMP‐2 in chronic leg ulcers and that its constituent growth factors may have the potential to redress the proteolytic imbalance observed in nonhealing chronic ulcers.
High-Resolution Submillimeter Constraints on Circumstellar Disk Structure

We present a high spatial resolution submillimeter continuum survey of 24 circumstellar disks in the Taurus-Auriga and Ophiuchus-Scorpius star formation regions using the SMA. In the context of a simple model, we use broadband spectral energy distributions and submillimeter visibilities to derive constraints on some basic parameters that describe the structure of these disks. For the typical disk in the sample we infer a radial surface density distribution Σr ∝ r-p with a median p ≈ 0.5, although consideration of the systematic effects of some of our assumptions suggest that steeper distributions with p ≈ 1 are more reasonable. The distribution of the outer radii of these disks shows a distinct peak at Rd ≈ 200 AU, with only a few cases where the disk emission is completely unresolved. Based on these disk structure measurements, the mass accretion rates, and the typical spectral and spatial distributions of submillimeter emission, we show that the observations are in good agreement with similarity solutions for steady accretion disks that have a viscosity parameter α ≈ 0.01. We provide new estimates of the spectral dependence of the disk opacity κν ∝ νβ with a mean β ≈ 1.0, corrected for optically thick emission. This typical value of β is consistent with model predictions for the collisional growth of solids to millimeter-size scales in the outer disk. Although direct constraints on planet formation in these disks are not currently available, the extrapolated density distributions inferred here are substantially shallower than those calculated based on the solar system or extrasolar planets and typically used in planet formation models. It is possible that we are substantially underestimating disk densities due to an incomplete submillimeter opacity prescription.
Intellectual capital efficiency level of Malaysian financial sector: Panel data analysis (2002-2006)

Intellectual capital which is encompasses of human capital, structural capital and capital employed has been regarded as a prominent source of competitive advantage of various organizations, which influence the level of innovativeness and creativity that lead to the increase of business performance and a country’s economic growth. Malaysia, as a progressive developing Asian country, must now focus on knowledge driven economy in order to be competitive and capable to face various challenges that exist in the global market. Malaysian financial sectors in particular, need to anticipate and rapidly respond to these demands and expectations in order to maintain their competitive edge in the industry.Therefore, the aim of this study is to examine the efficiency level and the trend of intellectual capital among Malaysian financial sectors and its impact on their company’s value added.Using a model introduced by Pulic (1998) to measure value added intellectual Capital(VAICtm) and panel data analysis to measure the trend of intellectual capital; it was found that out of 18 companies evaluated from year 2002-2006, banking sectors owning more on intellectual capital followed by insurance company and brokerage firm. Company’s value added was very much related to the amount of capital employed as compared to other variables. The trend of intellectual capital shows positive relationship for almost all sectors. However the relationships was found insignificant.
SPECTRAL-ELEMENT DISCONTINUOUS GALERKIN ( SEDG ) SIMULATIONS WITH A MOVING WINDOW ALGORITHM FOR WAKEFIELD CALCULATIONS

We developed a moving window algorithm for wakefield calculations for our SEDG time-domain electromagnetic code NekCEM. When the domain of interest is around a moving bunch within a certain distance, one does not need to carry out full domain simulations. The moving window approach is a natural choice for reducing the computational cost of the conventional low-order methods such as the finite-difference time-domain method [6]. However, there have not been studies on high-order methods, especially the SEDG method, based on the moving window approach. We implemented a 3D moving window option for wakefield calculations on various conducting cavities including a 9-cell TESLA cavity. We demonstrate the performance of the SEDG simulations on moving window meshes.
Evaluation of different mathematical models and different b-value ranges of diffusion-weighted imaging in peripheral zone prostate cancer detection using b-value up to 4500 s/mm2

Objectives To evaluate the diagnostic performance of different mathematical models and different b-value ranges of diffusion-weighted imaging (DWI) in peripheral zone prostate cancer (PZ PCa) detection. Methods Fifty-six patients with histologically proven PZ PCa who underwent DWI-magnetic resonance imaging (MRI) using 21 b-values (0–4500 s/mm2) were included. The mean signal intensities of the regions of interest (ROIs) placed in benign PZs and cancerous tissues on DWI images were fitted using mono-exponential, bi-exponential, stretched-exponential, and kurtosis models. The b-values were divided into four ranges: 0–1000, 0–2000, 0–3200, and 0–4500 s/mm2, grouped as A, B, C, and D, respectively. ADC, , D*, f, DDC, α, Dapp, and Kapp were estimated for each group. The adjusted coefficient of determination (R2) was calculated to measure goodness-of-fit. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic performance of the parameters. Results All parameters except D* showed significant differences between cancerous tissues and benign PZs in each group. The area under the curve values (AUCs) of ADC were comparable in groups C and D (p = 0.980) and were significantly higher than those in groups A and B (p< 0.05 for all). The AUCs of ADC and Kapp in groups B and C were similar (p = 0.07 and p = 0.954), and were significantly higher than the other parameters (p< 0.001 for all). The AUCs of ADC in group D was slightly higher than Kapp (p = 0.002), and both were significantly higher than the other parameters (p< 0.001 for all). Conclusions ADC derived from conventional mono-exponential high b-value (3200 s/mm2) models is an optimal parameter for PZ PCa detection.
Flower choice by naı̈ve young crab spiders and the effect of subsequent experience

Initial responses of naïve individuals to critical environmental stimuli provide important information about the innate contribution to behaviour, and subsequent responses to the same stimuli may show the role of experience in mediating those initial responses. To test the role of these factors, I measured initial patch choices and giving-up responses of just-emerged, naïve, second-instar crab spiders, Misumena vatia, on several hunting sites they encountered after leaving their natal nests. In follow-up tests I measured the effects of these experiences on subsequent patch choice decisions. The choice of hunting sites is a vital decision at all stages of the life cycle for sit-and-wait predators such as Misumena. In their initial tests these spiderlings remained more frequently on goldenrod (Solidago spp.) flowers than on green or yellow goldenrod buds, a preference they retained through tests run on 5 consecutive days. Individuals on green and yellow buds shifted sites more quickly and frequently than those from flowers, and made most of these moves to flowers, which attracted many more prey than did buds. These differences were not affected by age, energetic condition, or loss of information over the period of the experiment. Once spiderlings moved from buds, they showed a high, increasing tendency to move from buds in subsequent runs, those from flowers showed a consistently low tendency. These results suggest that spiderlings retain their innate behavioural patterns through the second instar, but that experience also plays a modest role in patch choice at this stage. Copyright 2000 The Association for the Study of Animal Behaviour.
Stand-alone performance of a computer-assisted detection prototype for detection of acute pulmonary embolism: a multi-institutional comparison.

OBJECTIVE To assess whether the performance of a computer-assisted detection (CAD) algorithm for acute pulmonary embolism (PE) differs in pulmonary CT angiographies acquired at various institutions. METHODS In this retrospective study, we included 40 consecutive scans with and 40 without PE from 3 institutions (n = 240) using 64-slice scanners made by different manufacturers (General Electric; Philips; Siemens). CAD markers were classified as true or false positive (FP) using independent evaluation by two readers and consultation of a third chest radiologist in discordant cases. Image quality parameters were subjectively scored using 4/5-point scales. Image noise and vascular enhancement were measured. Statistical analysis was done to correlate image quality of the three institutions with CAD stand-alone performance. RESULTS Patient groups were comparable with respect to age (p = 0.22), accompanying lung disease (p = 0.12) and inpatient/outpatient ratio (p = 0.67). The sensitivity was 100% (34/34), 97% (37/38) and 92% (33/36), and the specificity was 18% (8/44), 15% (6/41) and 13% (5/39). Neither significantly differed between the institutions (p = 0.21 and p = 0.820, respectively). The mean number of FP findings (4.5, 6.2 and 3.7) significantly varied (p = 0.02 and p = 0.03), but median numbers (2, 3 and 3) were comparable. Image quality parameters were significantly associated with the number of FP findings (p<0.05) but not with sensitivity. After correcting for noise and vascular enhancement, the number of FPs did not significantly differ between the three institutions (p = 0.43). CONCLUSIONS CAD stand-alone performance is independent of scanner type but strongly related to image quality and thus scanning protocols.