Miracle-dz/UniFAR-FTUs huggingface dataset:
Semantic feature analysis: Application to confrontation naming of actions in aphasia

Background: Despite advances in the development and testing of therapies for verb retrieval impairments in aphasia, generalisation effects of treatment remain a challenge. Semantic Feature Analysis (SFA) is a word retrieval treatment that has been reported to result in generalised responding to untrained object names with persons with aphasia. The theorised therapeutic mechanisms of SFA appeared to be appropriate for facilitating retrieval of trained and untrained action names. Aims: This investigation was designed to extend pilot research in which SFA was applied to verb retrieval. The primary purpose of the current study was to examine the acquisition and response generalisation effects of SFA applied to action naming with four persons with chronic aphasia. Additional purposes were to examine changes in production of content in discourse and to explore the correspondence of accuracy of naming during treatment to probe performance. Methods & Procedures: SFA was modified slightly to be appropriate for application to action naming as opposed to object naming; several feature categories were changed, but all other procedures were retained. Treatment was applied sequentially to two sets of action names in the context of multiple baseline designs across behaviours and participants. Accuracy of naming of trained and untrained actions in probes was measured repeatedly throughout all phases of the design. Production of correct information units (CIUs) in discourse was measured prior to and following treatment. The relationship of probe-naming performance to naming performance during treatment sessions was examined using correlational analyses. Outcomes & Results: Increased accuracy of naming of trained action names was associated with treatment for three of the four participants. The remaining participant did not demonstrate improvement in naming on probes, despite some gains during treatment. Generalisation to untrained action names did not occur for any of the participants. Increases in CIU production were observed for only one of the participants. For the participants with positive naming outcomes, probe performance correlated well with naming performance during treatment. For the participant who demonstrated some improvements in treatment, but did not show gains in naming on probes, weak correlations were obtained. Conclusions: SFA appears to have potential for promoting improved action naming in aphasia. However, more research is warranted to explore treatment modifications to promote generalisation. Correlational analyses indicated that gains in naming during treatment may not always be reflected in probe performance and thus, require verification through probing in non-treatment conditions.
Power and Subjectivity at Work: From Degradation to Subjugation in Social Relations

The paper presents a critical exploration of the treatment of subjectivity and power in sociology through an examination of recent developments in labour process theory. This is introduced through a discussion of dualism and the study of power. It is then argued that the exposure of the neglect of subjectivity in the response to Labour and Monopoly Capital has not been matched by effort to remedy this deficiency. Originating in Marx, the intellectual history of this neglect is explored through a review of key contributions to the post-Braverman literature. Our argument draws upon the work of Foucault to suggest a more adequate appreciation of processes of subjugation in which subjectivity is fetishised in identity. This thesis is articulated and illustrated through a critique of the influential empirical studies of Burawoy and Cockburn.
Errors generated by a point-of-care CD4+ T-lymphocyte analyser: a retrospective observational study in nine countries

Abstract Objective To estimate the proportion of invalid results generated by a CD4+ T-lymphocyte analyser used by Médecins Sans Frontières (MSF) in field projects and identify factors associated with invalid results. Methods We collated 25 616 CD4+ T-lymphocyte test results from 39 sites in nine countries for the years 2011 to 2013. Information about the setting, user, training, sampling technique and device repair history were obtained by questionnaire. The analyser performs a series of checks to ensure that all steps of the analysis are completed successfully; if not, an invalid result is reported. We calculated the proportion of invalid results by device and by operator. Regression analyses were used to investigate factors associated with invalid results. Findings There were 3354 invalid test results (13.1%) across 39 sites, for 58 Alere PimaTM devices and 180 operators. The median proportion of errors per device and operator was 12.7% (interquartile range, IQR: 10.3–19.9) and 12.1% (IQR: 7.1–19.2), respectively. The proportion of invalid results varied widely by country, setting, user and device. Errors were not associated with settings, user experience or the number of users per device. Tests performed on capillary blood samples were significantly less likely to generate errors compared to venous whole blood. Conclusion The Alere Pima CD4+ analyser generated a high proportion of invalid test results, across different countries, settings and users. Most error codes could be attributed to the operator, but the exact causes proved difficult to identify. Invalid results need to be factored into the implementation and operational costs of routine CD4+ T-lymphocyte testing.
Dimensions and their poles: A metric and topological approach to opposites

We explored the nature of 37 spatial dimensions in Italian, such as lungo–corto (long–short), inizio–fine (beginning–end), and convergente–divergente (convergent–divergent). In Study 1 we investigated their metric structure. We asked: (1) Are the extensions of the two poles (P 1 and P 2) the same? (2) What proportion of each dimension can be said to be neither P 1 nor P 2? and (3) Is the extension of P 1 that can be called neither P 1 nor P 2, the same as the extension of P 2 that can be called neither P 1 nor P 2? In Study 2 we investigated the topological structure of the dimensions. We asked: (1) Are the poles, points or ranges? (2) Do intermediates (neither P 1 nor P 2) exist? and (3) If they do, are they points or ranges? Two metric properties explained a considerable proportion of the variation in the responses in the first task: (1) the asymmetry of the extension of the two poles and (2) the extension of the “neither–nor” region between them. The results of the topological task further refined the two-dimensional structure obtained in Study 1 to produce a map of spatial opposites. Our methods and the resulting maps provide a point of departure from which two questions can be investigated: (1) If these methods were used in other languages to study spatial opposites, to what extent would they produce similar maps of opposites? and (2) If these methods were applied to nonspatial opposites and maps analogous to our spatial maps were generated, would any dense regions in the nonspatial maps coincide with sparse regions in the spatial maps? We discuss the potential importance of these questions.
School social capital and secondary education plans

This article intends to identify the effects of school social capital on the educational plans of students, particularly those staying in school and obtaining an intermediate certificate. It is hypothesised that social capital helps to explain individual educational plans and differences between schools regarding the amount of students with particular educational plans. The analyses are based on a survey of 1638 year 8 Hauptschule students in Germany. The results show that the quality of relationships with teachers is of crucial importance for the educational plans of individual students. Furthermore, differences between schools can be explained by the degree of school expectations. This finding supports the assumption that schools provide different settings, not only for learning processes but also for developing educational aspirations and plans.
Deromancing leadership: what are the behaviours of highly effective middle managers?

How must a middle manager behave to be effective? Despite the heightened importance of middle managers, this fundamental question in the field of leadership remains largely unanswered. An understanding of the key behaviours displayed by effective middle managers provides an opportunity for enhanced productivity and improved organisational performance. Rather than focus on observable behaviours, most leadership literature yields long survey lists of attributions and perceptions. We dismiss this reliance on attributions in leadership writings, and argue that the focus should, instead, be shifted toward the observable and trainable behaviours and behavioural patterns of highly effective middle managers. Observing the real-life behaviours of highly effective middle managers will further detail as well as go beyond the transformational and transactional leadership paradigm. Four mutually exclusive, behavioural classes we have developed for analysing such observations are: "Steering", "Supporting", "Self-defending" and "Sounding".
The Experience and Consequences of Perceived Racial Discrimination: A Study of African Americans

This exploratory study investigates the link between the experience of racial discrimination and personal outcomes in a sample of African Americans. Most research on discrimination and its consequences has focused on institutional discrimination. Little attention has been given to “isolate discrimination,” an individual act of discriminatory behavior by one dominant group person directed at a member of a subordinate group. In this exploratory study, with a sample of 312 Blacks, the authors examine the experience and consequences of discrimination among African Americans from Detroit, Michigan. Consistent with prior literature, the authors hypothesize that discrimination affects the sense of mastery and creates psychological distress. The authors find that experiencing discrimination leads to lower levels of mastery and higher levels of psychological distress. These results support the authors’hypotheses. The authors discuss several implications of these results.
Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of c-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis

Purpose: Currently, there are no approved targeted therapies for the treatment of ovarian cancer, despite the fact that it is the most lethal gynecological malignancy. One proposed target is c-Met, which has been shown to be an important prognostic indicator in a number of malignancies, including ovarian cancer. The objective of this study was to determine whether an orally available multikinase inhibitor of c-Met and vascular endothelial growth factor receptor-2 (foretinib, GSK1363089) blocks ovarian cancer growth. Experimental Design: The effect of foretinib was tested in a genetic mouse model of endometrioid ovarian cancer, several ovarian cancer cell lines, and an organotypic 3D model of the human omentum. Results: In the genetic mouse model, treatment with foretinib prevented the progression of primary tumors to invasive adenocarcinoma. Invasion through the basement membrane was completely blocked in treated mice, whereas in control mice, invasive tumors entirely replaced the normal ovary. In 2 xenograft mouse models using human ovarian cancer cell lines, the inhibitor reduced overall tumor burden (86% inhibition, P < 0.0001) and metastasis (67% inhibition, P < 0.0001). The mechanism of inhibition by foretinib involved (a) inhibition of c-Met activation and downstream signaling, (b) reduction of ovarian cancer cell adhesion, (c) a block in migration and invasion, (d) reduced proliferation mediated by a G2–M cell-cycle arrest, and (e) induction of anoikis. Conclusions: This study shows that foretinib blocks tumorigenesis and reduces invasive tumor growth in different models of ovarian cancer by affecting several critical tumor functions. We believe that it provides a rationale for the further clinical development of foretinib for the treatment of ovarian cancer. Clin Cancer Res; 17(12); 4042–51. ©2011 AACR.
Subcellular distribution of importins correlates with germ cell maturation

Importin proteins regulate access to the nucleus by recognizing and transporting distinct cargo proteins. Building on studies in Drosophila and Caenorhabditis elegans, we hypothesized that regulated expression and subcellular localization of specific importins may be linked to mammalian gonadal differentiation. We identified distinct developmental and cellular localization patterns for importins β1, α3, α4 and RanBP5 (importin β3) in fetal and postnatal murine testes using Western blotting and immunohistochemistry. Importin β1 protein is detected in selected germ and somatic cells in fetal gonads, with a striking perinuclear staining evident from embryonic day (E) 14.5 within testicular gonocytes. RanBP5 exhibits age‐ and gender‐specific subcellular localization within fetal gonads. At E12.5, RanBP5 protein is cytoplasmic in gonocytes but predominantly nuclear in oogonia, but by E14.5 RanBP5 appears nuclear in gonocytes and cytoplasmic in oogonia. In postnatal testes, importin α3 and α4 in spermatocytes, spermatids, and Sertoli cells display cytoplasmic and nuclear localization, respectively. Developmental Dynamics 236: 2311–2320, 2007. © 2007 Wiley‐Liss, Inc.
α-Glucosidase inhibition, 15-lipoxygenase inhibition, and brine shrimp toxicity of extracts and isolated compounds from Terminalia macroptera leaves

Abstract Context: Terminalia macroptera Guill. & Perr. (Combretaceae), a tree that grows in West Africa, has been used in traditional medicine against a variety of diseases such as hepatitis, gonorrhea, skin diseases, and diabetes. Objective: To investigate enzyme inhibitory activity against α-glucosidase and 15-lipoxygenase (15-LO) and toxicity against brine shrimp of extracts and compounds from T. macroptera leaves. Materials and methods: Methanol extract, ethyl acetate, and butanol extracts obtained from the methanol extract, six isolated polyphenols (chebulagic acid, chebulic acid trimethyl ester, corilagin, methyl gallate, narcissin, and rutin), and shikimic acid were evaluated for enzyme inhibition and toxicity. Results: In enzyme inhibition assays, all extracts showed high or very high activity. Chebulagic acid showed an IC50 value of 0.05 µM towards α-glucosidase and 24.9 ± 0.4 µM towards 15-LO, in contrast to positive controls (acarbose: IC50 201 ± 28 µM towards α-glucosidase, quercetin: 93 ± 3 µM towards 15-LO). Corilagin and narcissin were good 15-LO and α-glucosidase inhibitors, as well, while shikimic acid, methyl gallate, and chebulic acid trimethyl ester were less active or inactive. Rutin was a good α-glucosidase inhibitor (IC50 ca. 3 µM), but less active towards 15-LO. None of the extracts or the isolated compounds seemed to be very toxic in the brine shrimp assay compared with the positive control podophyllotoxin. Conclusion: Inhibition of α-glucosidase in the gastrointestinal tract may be a rationale for the medicinal use of T. macroptera leaves against diabetes in traditional medicine in Mali. The plant extracts and its constituents show strong inhibition of the peroxidative enzyme 15-LO.
A rating scale to screen symptoms of psychiatric disorders in children

To be able to offer children with developmental disorders adequate help, professionals working in special needs education must use a screening device to assess the specific psychiatric difficulties of the children. In this paper the psychometric properties of an easy‐to‐use parental rating scale to screen symptoms of major psychiatric disorders (ADHD, ODD, CD, Generalized Anxiety Disorder, Social Phobia, Depression and Autism) are investigated in a random sample of 2536 Dutch children that were rated by their parents. The internal, inter‐rater and test–retest reliabilities all meet the requirements set out for rating scales intend for diagnostic purposes. Parental ratings show a consistent pattern of convergent and divergent validity with CBCL scores. Predictive validity was demonstrated in reference to children receiving mental health services.
Contributions of Research in Bibliotherapy to the Language-Arts Program. I

for teachers, librarians, psychologists, and psychiatrists. Many of the articles have been written for and by librarians and others working with patients in general and mental hospitals, and these efforts are largely descriptive rather than experimental. In educational literature, studies of the relationships between reading difficulties and personality maladjustments have been summarized by Gates (24), by Wilking (73), and by Russell (52). Russell p ints out that evidence of the positive effects of reading is largely lacking. Most of the writing summarized below deals with hypotheses about the proc ss of bibliotherapy. A few illustrations of the use of bibliotherapy in case-study approaches to research in medical institutions, in libraries, and in schools can be given. General summaries of research in bibliotherapy. -These studies are limited in scope and content. In a pioneer volume in 1923 Jones (30) discussed uses of books in hospital libraries and gave classified reading lists. Bryan later wrote a series of three articles
Distributed Spectrum Sensing and Access in Cognitive Radio Networks With Energy Constraint

We design distributed spectrum sensing and access strategies for opportunistic spectrum access (OSA) under an energy constraint on secondary users. Both the continuous and the bursty traffic models are considered for different applications of the secondary network. In each slot, a secondary user sequentially decides whether to sense, where in the spectrum to sense, and whether to access. By casting this sequential decision-making problem in the framework of partially observable Markov decision processes, we obtain stationary optimal spectrum sensing and access policies that maximize the throughput of the secondary user during its battery lifetime. We also establish threshold structures of the optimal policies and study the fundamental tradeoffs involved in the energy-constrained OSA design. Numerical results are provided to investigate the impact of the secondary user's residual energy on the optimal spectrum sensing and access decisions.
Production Regimes and the Quality of Employment in Europe

AbstractProduction regime theory has been one of the most innovative and influential recent contributions to neo-institutional debates about the varieties of capitalism. This review takes issue with its claim that there are major differences in the quality of work between the two principal regime types that are held to characterize European societies—coordinated market economies and liberal market economies—by examining the evidence for Denmark, Finland, Germany, Sweden, and the UK. Although the broad pattern of skill differences corresponds reasonably well to the arguments of the theory, the evidence does not confirm the other claims about work and employment conditions, in particular with respect to employee job control, autonomous work teams, organizational participation, and job security. Rather, it points to the distinctiveness of the Scandinavian countries and hence to the importance of factors that lie outside the explanatory framework of the thesis.
Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses

Osteochondrosis arises as a result of focal failure of the blood supply to growth cartilage. The current aim was to examine the pathogenesis of pseudocysts and true cysts in subchondral bone following failure of the blood supply to the articular-epiphyseal cartilage complex in horses. Cases were recruited based on identification of lesions (n = 17) that were considered likely to progress to or to represent pseudocysts or true cysts in epiphyseal bone in histological sections and included 10 horses ranging in age from 48 days to 5 years old. Cases comprised 3 warmbloods, 3 Standardbreds, 1 Quarter horse and 1 Arabian with spontaneous lesions and 2 Fjord ponies with experimentally induced lesions. Seven lesions consisted of areas of ischemic chondronecrosis and were compatible with pseudocysts. Two lesions were located at intermediate depth in epiphyseal growth cartilage, 2 lesions were located in the ossification front, 2 lesions were located in epiphyseal bone and 1 lesion was located in the metaphyseal growth plate (physis). Ten lesions contained dilated blood vessels and were compatible with true cysts. In 2 lesions the dilated blood vessels were located within the lumina of failed cartilage canals. In the 8 remaining lesions areas of ischemic chondronecrosis were associated with granulation tissue in the subjacent bone and dilated vessels were located within this granulation tissue. Failure of the blood supply and ischemic chondronecrosis can lead to formation of pseudocysts or dilatation of blood vessels and formation of true cysts in the epiphyseal bone of horses.
Psychiatry trainees’ views and educational needs regarding the care of patients with a life-limiting illness

Abstract Objective: People with a life-limiting physical illness experience high rates of significant psychological and psychiatric morbidity. Nevertheless, psychiatrists often report feeling ill-equipped to respond to the psychiatric needs of this population. Our aim was to explore psychiatry trainees’ views and educational needs regarding the care of patients with a life-limiting physical illness. Method: Using semistructured interviews, participants’ opinions were sought on the role of psychiatrists in the care of patients with a life-limiting illness and their caregivers, the challenges faced within the role, and the educational needs involved in providing care for these patients. Interviews were audiotaped, fully transcribed, and then subjected to thematic analysis. Results: A total of 17 psychiatry trainees were recruited through two large psychiatry training networks in New South Wales, Australia. There were contrasting views on the role of psychiatry in life-limiting illness. Some reported that a humanistic, supportive approach including elements of psychotherapy was helpful, even in the absence of a recognizable mental disorder. Those who reported a more biological and clinical stance (with a reliance on pharmacotherapy) tended to have a nihilistic view of psychiatric intervention in this setting. Trainees generally felt ill-prepared to talk to dying patients and felt there was an educational “famine” in this area of psychiatry. They expressed a desire for more training and thought that increased mentorship and case-based learning, including input from palliative care clinicians, would be most helpful. Significance of Results: Participants generally feel unprepared to care for patients with a life-limiting physical illness and have contrasting views on the role of psychiatry in this setting. Targeted education is required for psychiatry trainees in order to equip them to care for these patients.
Mandarin Chinese compounds, their representation, and processing in the visual modality

This article reviews a number of key linguistic and psycholinguistic findings pertaining to Mandarin Chinese compound words, their representation, and their processing in the visual modality. A summary of a number of key facts about compounds and compounding in general is followed by a linguistic overview of Mandarin compounds. Next, the issue of the basic unit of representation in the Mandarin mental lexicon is discussed, and the conclusion is reached that this unit is the word rather than the morpheme. A number of factors influencing visual access to compounds in languages in general and Mandarin in particular are identified and empirical findings on these factors are summarized. The article concludes by examining the relationship between Chinese orthography and compound processing in Mandarin and by identifying a number of issues which await to be addressed in future research.