Miracle-dz/UniFAR-FTUs huggingface dataset:
PRELIMINARY . PLEASE DO NOT CITE Subsidized Birth Control and Women ’ s Outcomes : Evidence from Regional Policy Changes

While most countries are committed to reducing unintended childbearing, and thereby improve the well being of both mothers and children, there is little consensus on what means will actually achieve this goal. This paper investigates the importance of one proposed policy: subsidized contraception. I make use of a series of unusual Swedish policy changes where different regions beginning in 1989 started subsidizing the birth control pill to examine the consequences for women’s outcomes. The reforms are attractive because they were significant and applied to all types of oral contraceptives. On average the subsidy rate was 75 percent. My identification strategy takes advantage of the fact that the reforms were implemented successively and only targeted specific cohorts of young women, mostly teenagers. This generates plausibly exogenous variation in access to the subsidy. Using extensive Swedish population micro data and aggregated county level data I find that access to the subsidy significantly increased consumption of the pill, reduced teenage childbearing and lowered abortion rates. However, there is no evidence that the reforms affected: labor supply, marriage educational attainment, or welfare dependency. The estimates are robust to a number of different sensitivity checks.
A study of the two northern open clusters NGC 1582 and NGC 1663

We present CCD UBV(I)C observations obtained in the field of the previously unstudied northern open clus- ters NGC 1582 and NGC 1663. For the former, we also provide high-resolution spectra of the brightest stars and complement our data with Two-Micron All-Sky-Survey (2MASS) near-infrared photometry and with astrometric data from the Tycho-2 catalog. From the analysis of all these data, we argue that NGC 1582 is a very poor, quite large and heavily contaminated open cluster. It turns out to have a reddening EB V= 0:350:03, to be situated 1100100 pc from the Sun and to have an age of 300100 Myr. On the other hand, we were not able to unambiguously clarify the nature of NGC 1663. By assuming it is a real cluster and from the analysis of its photometric diagrams, we found a color excess value EB V = 0:20, an intermediate age value (2000 Myr) and a distance of about 700 pc. The distribution of the stars in the region however suggests we are probably facing an open cluster remnant. As an additional result, we obtained aperture photometry of three previously unclassified galaxies placed in the field of NGC 1663 and performed a preliminary morphological classification of them.
Determinants of overweight and obesity among urban school-going children and adolescents: a case-control study in Bangladesh

Abstract Background Childhood overweight and obesity is a major public health concern all over the world. Overweight or obese children have a higher risk of becoming obese in adulthood and are at higher risk of associated chronic diseases. Objective The aim of this study was to determine the risk factors associated with overweight and obesity among urban school children and adolescents in Bangladesh. Materials and methods A case-control study was conducted among students aged 10–16 years in 10 schools of Dhaka city. A structured questionnaire was used to collect socio-demographic information and students’ exposure to various risk factors. Data were analyzed by using SPSS 23. Results Family income (p = 0.000), mother’s weight (p = 0.036), school activity (p = 0.046), total physical activity (p = 0.008), sedentary activities (p = 0.014), eating fast food (0.008) and cakes/biscuits (p = 0.018) were found as potential determinants of overweight and obesity of children and adolescents. A multiple logistic regression revealed family income >50,000 per month [adjusted odds ratio (AOR) = 3.07, p = 0.001], no physical activity (AOR = 38.3, p = 0.004), more than 4 h of sedentary activities (AOR = 4.84, p = 0.02), regular consumption of fast food (AOR = 3.05, p = 0.042) are risk factors associated with childhood overweight/obesity. Whereas, having a normal weight mother (AOR = 0.51, p = 0.037) and eating cakes/biscuits less than 3 days a week (AOR = 0.33, p = 0.02) were found as protective factors. Conclusion Findings from this study will be very useful for public health professionals to increase awareness regarding risk factors of overweight and obesity, in order to reduce the future burden of obesity-associated chronic diseases.
Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome.

PURPOSE Pseudoexfoliation (PEX) syndrome/glaucoma is a complex, late-onset disorder of the elastic fiber system. Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) gene, but additional comodulating factors are necessary for the manifestation of the disease. The aim of this study was to analyze the effect of various PEX-associated pathogenic factors on the genotype-correlated expression of LOXL1 and elastin-related genes. METHODS Cultured human Tenon's capsule fibroblasts with high- and low-risk LOXL1 haplotypes were exposed to transforming growth factor (TGF)-β1, interleukin (IL)-6, homocysteine, oxidative stress, hypoxia, or ultraviolet (UV) radiation. Changes in the expression of LOXL1 and elastic constituents of PEX material and TGF-β1 were assessed by quantitative real-time PCR, Western blotting, immunohistochemistry, and electron microscopy. RESULTS Treatment of fibroblasts with TGF-β1, oxidative stress, UV light, and hypoxia induced a significant increase in expression levels of LOXL1 and elastic proteins, whereas the effect of IL-6 was limited to induction of elastic constituents. Immunohistochemistry and electron microscopy confirmed an upregulation of LOXL1 and elastic fiber proteins and their assembly into extracellular microfibrillar networks with focal aggregation of microfibrils into PEX-like fibrils on stimulation with TGF-β1 and oxidative stress. Basal and stimulated expression of LOXL1 mRNA and protein was slightly decreased in cells carrying the high-risk compared with the low-risk haplotype of LOXL1, but the differences between groups were statistically not significant. CONCLUSIONS The findings support the notion that both genetic and nongenetic fibrogenic factors, particularly TGF-β1 and oxidative stress, may cooperate in the stable accumulation of PEX aggregates.
The value of visible 5-ALA fluorescence and quantitative protoporphyrin IX analysis for improved surgery of suspected low-grade gliomas.

OBJECTIVEIn patients with suspected diffusely infiltrating low-grade gliomas (LGG), the prognosis is dependent especially on extent of resection and precision of tissue sampling. Unfortunately, visible 5-aminolevulinic acid (5-ALA) fluorescence is usually only present in high-grade gliomas (HGGs), and most LGGs cannot be visualized. Recently, spectroscopic probes were introduced allowing in vivo quantitative analysis of intratumoral 5-ALA-induced protoporphyrin IX (PpIX) accumulation. The aim of this study was to intraoperatively investigate the value of visible 5-ALA fluorescence and quantitative PpIX analysis in suspected diffusely infiltrating LGG.METHODSPatients with radiologically suspected diffusely infiltrating LGG were prospectively recruited, and 5-ALA was preoperatively administered. During resection, visual fluorescence and absolute tissue PpIX concentration (CPpIX) measured by a spectroscopic handheld probe were determined in different intratumoral areas. Subsequently, corresponding tissue samples were safely collected for histopathological analysis. Tumor diagnosis was established according to the World Health Organization 2016 criteria. Additionally, the tumor grade and percentage of tumor cells were investigated in each sample.RESULTSAll together, 69 samples were collected from 22 patients with histopathologically confirmed diffusely infiltrating glioma. Visible fluorescence was detected in focal areas in most HGGs (79%), but in none of the 8 LGGs. The mean CPpIX was significantly higher in fluorescing samples than in nonfluorescing samples (0.693 μg/ml and 0.008 μg/ml, respectively; p < 0.001). A significantly higher mean percentage of tumor cells was found in samples with visible fluorescence compared to samples with no fluorescence (62% and 34%, respectively; p = 0.005), and significant correlation of CPpIX and percentage of tumor cells was found (r = 0.362, p = 0.002). Moreover, high-grade histology was significantly more common in fluorescing samples than in nonfluorescing samples (p = 0.001), whereas no statistically significant difference in mean CPpIX was noted between HGG and LGG samples. Correlation between maximum CPpIX and overall tumor grade was highly significant (p = 0.005). Finally, 14 (40%) of 35 tumor samples with no visible fluorescence and 16 (50%) of 32 LGG samples showed significantly increased CPpIX (cutoff value: 0.005 μg/ml). CONCLUSIONSVisible 5-ALA fluorescence is able to detect focal intratumoral areas of malignant transformation, and additional quantitative PpIX analysis is especially useful to visualize mainly LGG tissue that usually remains undetected by conventional fluorescence. Thus, both techniques will support the neurosurgeon in achieving maximal safe resection and increased precision of tissue sampling during surgery for suspected LGG.Clinical trial registration no.: NCT01116661 (clinicaltrials.gov).
LightSit: An Unobtrusive Health-Promoting System for Relaxation and Fitness Microbreaks at Work

Physical inactivity and chronic stress at work increase the risks of developing metabolic disorders, mental illnesses, and musculoskeletal injuries, threatening office workers’ physical and psychological well-being. Although several guidelines and interventions have been developed to prevent theses subhealth issues, their effectiveness and health benefits are largely limited when they cannot match workday contexts. This paper presents LightSit, a health-promoting system that helps people reduce physically inactive behaviors and manage chronic stress at work. LightSit comprises a sensor mat that can be embedded into an office chair for measuring a user’s sitting posture and heart rate variability and a lighting display that is integrated into a monitor stand to present information unobtrusively, facilitating fitness and relaxation exercises during microbreaks. Following the showroom approach, we evaluated LightSit during a public exhibition at Dutch Design Week 2018. During the eight days of the exhibition, we observed more than 500 sessions of experiences with healthy microbreaks using our prototype. Semistructured interviews were conducted with 50 participants who had office-based jobs and had experienced LightSit. Our qualitative findings indicated the potential benefits of LightSit in facilitating health-promoting behaviors during office work. Based on the insights learned from this study, we discuss the implications for future designs of interactive health-promoting systems.
Non-orthogonal Multiple Access (NOMA) with Successive Interference Cancellation for Future Radio Access

SUMMARY This paper presents our investigation of non-orthogonal multiple access (NOMA) as a novel and promising power-domain user multiplexing scheme for future radio access. Based on information theory, we can expect that NOMA with a successive interference canceller (SIC) applied to the receiver side will offer a better tradeoff between system efficiency and user fairness than orthogonal multiple access (OMA), which is widely used in 3.9 and 4G mobile communication systems. This improvement becomes especially significant when the channel conditions among the non-orthogonally multiplexed users are significantly different. Thus, NOMA can be expected to efficiently exploit the near-far effect experienced in cellular environments. In this paper, we describe the basic principle of NOMA in both the downlink and uplink and then present our proposed NOMA scheme for the scenario where the base station is equipped with multiple antennas. Simulation results show the potential system-level
A systematic review of patient‐reported outcomes associated with the use of direct‐acting oral anticoagulants

Patient‐reported outcomes (PROs) are a distinctive method of evaluating patient response to health care or treatment. This systematic review aimed to analyse the impact of PROs in patients on direct oral anticoagulant (DOAC) treatment, prescribed for any indication (e.g. venous thromboembolism treatment or atrial fibrillation) using controlled trials (CT) and real‐world observational studies (OS).
Swift Observations of the Cooling Accretion Disk of XTE J1817–330

The black hole candidate X-ray transient XTE J1817-330 was observed by the Swift satellite over 160 days of its 2006 outburst with the XRT and UVOT instruments. At the start of the observations, the XRT spectra show that the 0.6-10 keV emission is dominated by an optically thick, geometrically thin accretion disk with an inner disk temperature of ~0.8 keV, indicating that the source was in a high/soft state during the initial outburst phase. We tracked the source through its decline into the low/hard state with the accretion disk cooling to ~0.2 keV and the inner disk radius consistent with the innermost stable circular orbit at all times. Furthermore, the X-ray luminosity roughly follows LX ∝ T4 during the decline, consistent with a geometrically stable blackbody. These results are the strongest evidence yet obtained that accretion disks do not automatically recede after a state transition, down to accretion rates as low as 0.001LEdd. Meanwhile, the near-UV flux does not track the X-ray disk flux and is well in excess of what is predicted if the near-UV emission is from viscous dissipation in the outer disk. The strong correlation between the hard X-ray flux and the near-UV flux, which scale as L, indicate that reprocessed emission is most likely the dominate contribution to the near-UV flux. We discuss our results in the context of accretion disks and the overall accretion flow geometry in accreting black holes.
The Interest Group Theory of Financial Development: Evidence from Regulation

We use a new dataset of de jure measures of trade, capital account, product market, and domestic financial regulation for 91 countries from 1973 to 2005 to test Rajan and Zingales’s (2003) interest group theory of financial development. In line with the theory, we find strong evidence that trade liberalization is a leading indicator of domestic financial liberalization. This result is robust to the use of different data frequencies (annual, 5-year intervals), estimation methods (OLS, 2SLS, system GMM) and a check for non-linear effects. However, in contrast to the theory, we do not find consistent evidence of an effect of capital account liberalization.
Relationship between Body Image and Body Weight Control in Overweight ≥55-Year-Old Adults: A Systematic Review

Objective: To assess the scientific evidence on the relationship between body image and body weight control in overweight ≥55-year-old adults. Methods: The literature search was conducted on MEDLINE database via PubMed, using terms related to body image, weight control and body composition. Inclusion criteria were scientific papers, written in English or Spanish, made on older adults. Exclusion criteria were eating and psychological disorders, low sample size, cancer, severe diseases, physiological disorders other than metabolic syndrome, and bariatric surgery. Results: Fifty-seven studies were included. Only thirteen were conducted exclusively among ≥55-year-old adults or performed analysis adjusted by age. Overweight perception was related to spontaneous weight management, which usually concerned dieting and exercising. More men than women showed over-perception of body image. Ethnics showed different satisfaction level with body weight. As age increases, conformism with body shape, as well as expectations concerning body weight decrease. Misperception and dissatisfaction with body weight are risk factors for participating in an unhealthy lifestyle and make it harder to follow a healthier lifestyle. Body image disturbance also made it more likely to underreport calorie intake. Conclusions: Aging is associated with a decrease in weight concerns and lower overweight perception, especially in women. However, when designing a program to improve body image in overweight ≥55-year-old adults, three items ought to be considered: physical activity, dietary and behavioral treatments.
Screening the expression of several miRNAs from TaqMan Low Density Array in traumatic brain injury: miR‐219a‐5p regulates neuronal apoptosis by modulating CCNA2 and CACUL1

Circulating microRNAs (miRNAs) have emerged as diagnostic and prognostic biomarkers for traumatic brain injury (TBI). However, a comprehensive characterization of the serum miRNA profile in patients with TBI and the roles of these potential markers in neuronal regulation have rarely been reported. In this study, the levels of 754 serum miRNAs were initially determined in two pooled samples of 15 severe traumatic brain injury (sTBI) patients and 15 healthy controls using a TaqMan Low Density Array. The markedly upregulated miRNAs in sTBI patients were subsequently validated individually by quantitative reverse‐transcription PCR (RT‐qPCR) in another larger cohort consisting of 81 sTBI patients, 81 mild traumatic brain injury (mTBI) patients and 82 age/sex‐matched healthy controls. Seven miRNAs, including miR‐103a‐3p, miR‐219a‐5p, miR‐302d‐3p, miR‐422a, miR‐518f‐3p, miR‐520d‐3p and miR‐627, were significantly upregulated in both sTBI and mTBI patients compared with their expression in controls. Among these miRNAs, miR‐219a‐5p not only discriminated sTBI and mTBI patients from controls but also discriminated between sTBI and mTBI patients. We further show here that in the neuronal cell injury model, upregulated miR‐219a‐5p inhibits the expression of CCNA2 and CACUL1 and further regulates akt/Foxo3a and p53/Bcl‐2 signaling pathways, causing a notable change in the expression of cleaved caspase‐3, thereby inducing neuronal apoptosis. These results indicate that these seven selected miRNAs could serve as novel biomarkers for TBI. In particular, miR‐219a‐5p is a potentially valuable indicator of the diagnosis, prognosis of TBI and appears to regulate neuronal apoptosis and death.
Classification of time delay estimates for robust speaker localization

This paper proposes a solution to the problem of robust speaker localization under adverse acoustic conditions. The approach is based on the classification of time delay estimates. Two classification techniques are investigated in detail: maximum likelihood (ML) classification and classification based on histogram comparison. Their performance under adverse acoustic conditions is compared to outcomes obtained with the traditional approach which uses time delay estimates directly to infer speaker positions. Experiments indicate that the ML classification method provides little improvement over the traditional method. On the other hand, using histogram classification, we can improve the probability of correct speaker localization by more than 60% compared to either the traditional approach or the ML classification technique.
Preliminary study on the application of deep learning system to diagnosis of Sjögren's syndrome on CT images.

OBJECTIVES This study estimated the diagnostic performance of a deep learning system for detection of Sjögren's syndrome (SjS) on CT, and compared it with the performance of radiologists. METHODS CT images were assessed from 25 patients confirmed to have SjS based on the both Japanese criteria and American-European Consensus Group criteria and 25 control subjects with no parotid gland abnormalities who were examined for other diseases. 10 CT slices were obtained for each patient. From among the total of 500 CT images, 400 images (200 from 20 SjS patients and 200 from 20 control subjects) were employed as the training data set and 100 images (50 from 5 SjS patients and 50 from 5 control subjects) were used as the test data set. The performance of a deep learning system for diagnosing SjS from the CT images was compared with the diagnoses made by six radiologists (three experienced and three inexperienced radiologists). RESULTS The accuracy, sensitivity, and specificity of the deep learning system were 96.0%, 100% and 92.0%, respectively. The corresponding values of experienced radiologists were 98.3%, 99.3% and 97.3% being equivalent to the deep learning, while those of inexperienced radiologists were 83.5%, 77.9% and 89.2%. The area under the curve of inexperienced radiologists were significantly different from those of the deep learning system and the experienced radiologists. CONCLUSIONS The deep learning system showed a high diagnostic performance for SjS, suggesting that it could possibly be used for diagnostic support when interpreting CT images.
Growth differentiation factor 15 may protect the myocardium from no-reflow by inhibiting the inflammatory-like response that predominantly involves neutrophil infiltration

The aim of the current study was to investigate the time course of the expression of growth differentiation factor-15 (GDF-15) in rat ischemic myocardium with increasing durations of reperfusion, and to elucidate its physiopathological role in the no-reflow phenomenon. Wistar rats were randomly divided into ischemia reperfusion (I/R) and sham groups, and myocardial I/R was established by ligation of the left anterior descending coronary artery for 1 h followed by reperfusion for 2, 4, 6, 12, 24 h and 7 days whilst rats in the sham group were subjected to a sham operation. The expression levels of GDF-15 and ICAM-1 were measured, in addition to myeloperoxidase (MPO) activity. The myocardial anatomical no-reflow and infarction areas were assessed. The area at risk was not significantly different following various periods of reperfusion, while the infarct area and no-reflow area were significantly greater following 6 h of reperfusion (P<0.05). The mRNA and protein expression levels of GDF-15 were increased during the onset and development of no-reflow, and peaked following 24 h of reperfusion. MPO activity was reduced with increasing reperfusion duration, while ICAM-1 levels were increased. Hematoxylin and eosin staining demonstrated that myocardial neutrophil infiltration was significantly increased by I/R injury, in particular following 2, 4 and 6 h of reperfusion. GDF-15 expression levels were negatively correlated with MPO activity (r=−0.55, P<0.001), and the MPO activity was negatively correlated with the area of no-reflow (r=−0.46, P<0.01). By contrast, GDF-15 was significantly positively correlated with ICAM-1 levels (r=0.52, P<0.01), which additionally were demonstrated to be significantly positively associated with the size of the no-reflow area (r= 0.39, P<0.05). The current study demonstrated the time course effect of reperfusion on the expression of GDF-15 in the myocardial I/R rat model, with the shorter reperfusion times (6 h) resulting in significant no-reflow in ischemic myocardium. GDF-15 may protect the I/R myocardium from no-reflow by inhibiting the inflammatory-like response, which involves neutrophil infiltration and transendothelial migration.
UAV based target finding and tracking in GPS-denied and cluttered environments

In this paper we describe and flight test a novel system architecture for low cost muti-rotor unmanned aerial vehicles (UAVs) for searching, tracking and following a ground target. The UAV uses only on-board sensors for localisation within a GPS-denied space with obstacles. This mission is formulated as a Partially Observable Markov Decision Process (POMDP) and uses a modular framework that runs on the Robotic Operating System (ROS). This system computes a policy for executing actions instead of way-points to navigate and avoid obstacles. Results indicate that the system is robust to overcome uncertainties in localisation of both, the aircraft and the target and avoids collisions with the obstacles.