Miracle-dz/UniFAR-FTUs huggingface dataset:
The Ramond Sector of Open Superstring Field Theory

Although the equations of motion for the Neveu-Schwarz (NS) and Ramond (R) sectors of open superstring field theory can be covariantly expressed in terms of one NS and one R string field, picture-changing problems prevent the construction of an action involving these two string fields. However, a consistent action can be constructed by dividing the NS and R states into three string fields which are real, chiral and antichiral. The open superstring field theory action includes a WZW-like term for the real field and holomorphic Chern-Simons-like terms for the chiral and antichiral fields. Different versions of the action can be constructed with either manifest d = 8 Lorentz covariance or manifest N = 1 d = 4 super-Poincar? covariance. The lack of a manifestly d = 10 Lorentz covariant action is related to the self-dual five-form in the type-IIB R-R sector.
Model for the Reduced Schiff Base Intermediate between Amino Acids and Pyridoxal: Copper(II) Complexes of N-(2-Hydroxybenzyl)amino Acids with Nonpolar Side Chains and the Crystal Structures of [Cu(N-(2-hydroxybenzyl)-D,L-alanine)(phen)].H(2)O and [Cu(N-(2-hydroxybenzyl)-D,L-alanine)(imidazole)].

Copper(II) complexes with reduced Schiff base ligands of amino acids possessing nonpolar side chains with salicylaldehyde have been synthesized. Ternary complexes with imidazole, 1,10-phenanthroline, and pyridine have been prepared and characterized for N-(2-hydroxybenzyl)-D,L-alanine. The crystal structures of [(N-(2-hydroxybenzyl)-D,L-alanine)(1,10-phenanthroline)Cu(II)] monohydrate ([Cu(SAla)phen]. H(2)O) and [(N-(2-hydroxybenzyl)-D,L-alanine)(imidazole)Cu(II)] ([Cu(SAla)Him]), have been determined. [Cu(SAla)phen]. H(2)O crystallized in space group P&onemacr;, with a = 8.718(2) Å, b = 10.886(3) Å, c = 11.693(2) Å, alpha = 71.32(2) degrees, beta = 85.27(2) degrees, gamma = 70.21(2) degrees, and Z = 2. The copper atom is five coordinate, with SAla acting as a tridentate ONO chelator through the carboxylato and phenolato oxygens and the amine nitrogen. The remaining donors are provided by the phen nitrogens. [Cu(SAla)Him] crystallized in space group P2(1)/n, with a = 10.353(1) Å, b = 6.714(1) Å, c = 18.769(2) Å, beta = 91.71(1) degrees, and Z = 4. The copper atom is four coordinate, with SAla acting as a tridentate ONO chelator with the neutral imidazole moiety coordinated through nitrogen. In both complexes the ligand has two chiral centers due to the coordination of the N. Molecular mechanics calculations show that unfavorable steric interactions would occur in the nonobserved R,R and S,S diastereomers. Compounds prepared have been characterized by a range of physicochemical techniques. The complexes may serve as stable models for the intermediates in enzymatic amino acid transformations.
Working Paper Green National Accounting : Why and How ?

The present paper gives an overview of the theory of green national accounting. Three purposes of green national accounting (measurement of welfare equivalent income, sustainable income, or net social profit) and two measures (Green NNP and wealth equivalent income) are considered. Under the assumption of no exogenous technological progress, Green NNP is shown to equal wealth equivalent income if there is a constant interest rate or if consumption is constant. It is established as a general result that sustainable income ≤ w alth equivalent income ≤ welfare equivalent income, while Green NNP ≤ welfare equivalent income under no exogenous technological progress and a constant utility discount rate. Green NNP is shown to measure gross social profit rather than et social profit. * Acknowledgments: I wish to thank CES, University of Munich, and the Norwegian Research Council (Ruhrgas grant) for hospitality and support during this research, Kjell Arne Brekke, Wolfgang Buchholz, John Hartwick, Atle Seierstad and two anonymous referees for helpful suggestions, and John Pezzey and Jeffrey Vincent for many detailed and useful comments. I am also grateful to Partha Dasgupta and Martin Weitzman for inspiring some of the analysis of the present paper by having made available their correspondence on green national accounting during the fall of 1997, and for commenting on an earlier version.
Antimicrobial susceptibility, virulence potential and sequence types associated with Arcobacter strains recovered from human faeces.

PURPOSE The genus Arcobacter includes bacteria that are considered emergent pathogens because they can produce infections in humans and animals. The most common symptoms are bloody and non-bloody persistent diarrhea but cases with abdominal cramps without diarrhea or asymptomatic cases have also been described as well as cases with bacteremia. The objective was to characterize Arcobacter clinical strains isolated from the faeces of patients from three Spanish hospitals. METHODOLOGY We have characterized 28 clinical strains (27 of A. butzleri and one of A. cryaerophilus) isolated from faeces, analysing their epidemiological relationship using the multilocus sequence typing (MLST) approach and screening them for their antibiotic susceptibility and for the presence of virulence genes.Results/Key findings. Typing results showed that only one of the 28 identified sequence types (i.e. ST 2) was already present in the MLST database. The other 27 STs constituted new records because they included new alleles for five of the seven genes or new combinations of known alleles of the seven genes. All strains were positive for the ciaB virulence gene and sensitive to tetracycline. However, 7.4 % of the A. butzleri and A. cryaerophilus strains showed resistance to ciprofloxacin. CONCLUSION The fact that epidemiological unrelated strains show the same ST indicates that other techniques with higher resolution should be developed to effectively recognize the infection source. Resistance to ciprofloxacin, one of the antibiotics recommended for the treatment of Arcobacter intestinal infections, demonstrated in 10.7 % of the strains, indicates the importance of selecting the most appropriate effective treatment.
Reinforcement Learning of Heuristic EV Fleet Charging in a Day-Ahead Electricity Market

This paper addresses the problem of defining a day-ahead consumption plan for charging a fleet of electric vehicles (EVs), and following this plan during operation. A challenge herein is the beforehand unknown charging flexibility of EVs, which depends on numerous details about each EV (e.g., plug-in times, power limitations, battery size, power curve, etc.). To cope with this challenge, EV charging is controlled during opertion by a heuristic scheme, and the resulting charging behavior of the EV fleet is learned by using batch mode reinforcement learning. Based on this learned behavior, a cost-effective day-ahead consumption plan can be defined. In simulation experiments, our approach is benchmarked against a multistage stochastic programming solution, which uses an exact model of each EVs charging flexibility. Results show that our approach is able to find a day-ahead consumption plan with comparable quality to the benchmark solution, without requiring an exact day-ahead model of each EVs charging flexibility.
Sequence-Independent Targeting of Transmembrane Proteins Synthesized within Vaccinia Virus Factories to Nascent Viral Membranes

ABSTRACT The primary membrane of vaccinia virus, as well as those of other poxviruses, forms within a discrete cytoplasmic factory region. We recently determined the existence of an operative pathway from the endoplasmic reticulum within the virus factory to nascent viral membranes and demonstrated that a viral protein could be diverted from this pathway to Golgi membranes by the addition of COPII-binding sites (M. Husain, A. S. Weisberg, and B. Moss, Proc. Natl. Acad. Sci. USA, 103:19506-19511, 2006). Here we describe an investigation of the structural features that are required for transit of proteins to the viral membrane. Deletion of either the N-terminal domain or the C-terminal cytoplasmic tail from the conserved A9 protein did not prevent its incorporation into viral membranes, whereas deletion of the transmembrane domain resulted in its distribution throughout the cytoplasm. Nevertheless, replacement of the A9 transmembrane domain with the corresponding region of a nonpoxvirus transmembrane protein or of a vaccinia virus extracellular envelope protein allowed viral membrane targeting, indicating no requirement for a specific amino acid sequence. Remarkably, the epitope-tagged A9 transmembrane domain alone, as well as a heterologous transmembrane domain lacking a poxvirus sequence, was sufficient for viral membrane association. The data are consistent with a sequence-independent pathway in which transmembrane proteins that are synthesized within the virus factory and lack COPII or other binding sites that enable conventional endoplasmic reticulum exiting are incorporated into nascent viral membranes.
Licensed Nursing Staff Reductions and Substitutions in Pennsylvania Hospitals, 1991–1997

Nurses report a decline in RN/patient and skill mix in the 1990s while quantitative studies fail to confirm this. This study examines aggregate hospital nursing staff in Pennsylvania from 1991–1997, focusing on changes in licensed nursing staff. It finds that licensed nursing staff declined while nursing assistants increased in this period. With adjustment for patient acuity, there was a slight decrease in RN/adjusted patient days of care (APDC), a 23% decrease in LPN/APDC, and a 4% decrease in licensed nurse/APDC. The RN/nurse ratio increased slightly, and licensed nurse/nurse fell slightly. Since RNs often operate in environments which make use of teams of licensed staff, nurses' perceptions of a decline in the RN/patient ratio is a result of the decline in licensed staff/APDC, and of an increase in patient acuity.
A Challenging Problem That Concerns the Aesthetic Surgeon: Postoperative Nausea and Vomiting

Postoperative nausea and vomiting (PONV) are among the most common adverse events in the postoperative period. This is especially disastrous in aesthetic surgery; it may cause hematoma, wound dehiscence, and patient dissatisfaction. The purpose of this study was to evaluate the incidence of PONV after aesthetic surgery procedures, and to determine the risk factors for PONV. Two hundred and twelve patients undergoing the most common aesthetic surgical procedures were included into this study. Female gender, surgical site, and history of PONV were found to be significant risk factors, however, postoperative opiate use and history of motion sickness were not found to be significant risk factors for PONV. Those undergoing trunk surgery procedures appeared to be at higher risk than were those undergoing head and neck surgery procedures. Also, ondansetron was found to be more affective than metoclopramide. Risk factors for PONV must be questioned preoperatively. Patients with risk factors are good candidates for prophylaxis. As a result of the effective prevention of PONV, postoperative patient comfort and satisfaction should be more improved.
Enhanced Airway Inflammation and Remodeling in Adenosine Deaminase-Deficient Mice Lacking the A2B Adenosine Receptor1

Adenosine is a signaling nucleoside that is generated in response to cellular injury and orchestrates the balance between tissue protection and the progression to pathological tissue remodeling. Adenosine deaminase (ADA)-deficient mice develop progressive airway inflammation and remodeling in association with adenosine elevations, suggesting that adenosine can promote features of chronic lung disease. Furthermore, pharmacological studies in ADA-deficient mice demonstrate that A2BR antagonism can attenuate features of chronic lung disease, implicating this receptor in the progression of chronic lung disease. This study examines the contribution of A2BR signaling in this model by generating ADA/A2BR double-knockout mice. Our hypothesis was that genetic removal of the A2BR from ADA-deficient mice would lead to diminished pulmonary inflammation and damage. Unexpectedly, ADA/A2BR double-knockout mice exhibited enhanced pulmonary inflammation and airway destruction. Marked loss of pulmonary barrier function and excessive airway neutrophilia are thought to contribute to the enhanced tissue damage observed. These findings support an important protective role for A2BR signaling during acute stages of lung disease.
Controlling Shareholders and the Acquisition Premiums Paid in European Takeover Bids

This paper examines the incentives of controlling shareholders in the market for corporate control. We investigate the takeover premiums paid by a sample of European acquiring firms with concentrated voting rights structures. The results show a positive relationship between takeover premiums and the bidder's concentration of both voting rights and excess voting rights over cash-flow rights. With higher levels of bidder entrenchment, the valuation of a takeover target increasingly reflects the private benefits of control which bidders seek to extract from a deal
A rapid and low-cost microscopic observation drug susceptibility assay for detecting TB and MDR-TB among individuals infected by HIV in South India.

BACKGROUND The converging epidemics of HIV and tuberculosis (TB) pose one of the greatest public health challenges of our time. Rapid diagnosis of TB is essential in view of its infectious nature, high burden of cases, and emergence of drug resistance. OBJECTIVE The purpose of this present study was to evaluate the feasibility of implementing the microscopic observation drug susceptibility (MODS) assay, a novel assay for the diagnosis of TB and multi-drug-resistant tuberculosis (MDR-TB) directly from sputum specimens, in the Indian setting. MATERIALS AND METHODS This study involved a cross-sectional, blinded assessment of the MODS assay on 1036 suspected cases of pulmonary TB in HIV-positive and HIV-negative patients against the radiometric method, BD-BACTEC TB 460 system. RESULTS Overall, the sensitivity, specificity, positive predictive value, and negative predictive value of the MODS assay in detecting MTB among TB suspected patients were 89.1%, 99.1%, 94.2%, 95.8%, respectively. In addition, in the diagnosis of drug-resistant TB, the MODS assay was 84.2% sensitive for those specimens reporting MDR, 87% sensitivity for those specimens reporting INH mono-resistance, and 100% sensitive for specimens reporting RIF mono-resistance. The median time to detection of TB in the MODS assay versus BACTEC was 9 versus 21 days (P<0.001). CONCLUSION Costing 5 to 10 times lesser than the automated culture methods, the MODS assay has the potential clinical utility as a simple and rapid method. It could be effectively used as an alternative method for diagnosing TB and detection of MDR-TB in a timely and affordable way in resource-limited settings.
Slow progression predicts poor prognoses in patients with spontaneous posterior interosseous nerve palsy

Abstract There are still no factors that predict the prognoses of patients with spontaneous posterior interosseous nerve palsies who are in an early phase of the illness. This paper reviewed 39 patients with this type of palsy. Seventeen patients who requested surgery for possible earlier recovery underwent interfascicular neurolysis because no signs of recovery were seen more than 3 months after onset. A Medical Research Council muscle power grade over 4 at their final visit was considered a good result, while a power less than grade 4 was considered a poor result. The clinical outcomes were significantly worse for the patients who had palsies with slow progressions (for more than 1 month) compared with those who had palsies with rapid progressions (completed within 1 month), regardless of their treatment. No significant difference was seen between the prognoses of patients with complete and incomplete palsies. We, therefore, recommend that interfascicular neurolysis is performed together with tendon transfer as the primary surgical procedures for patients with palsies with slow progression.
Fitness‐dependent mutation rates in finite populations

Mutation rate may be condition dependent, whereby individuals in poor condition, perhaps from high mutation load, have higher mutation rates than individuals in good condition. Agrawal (J. Evol. Biol.15, 2002, 1004) explored the basic properties of fitness‐dependent mutation rate (FDMR) in infinite populations and reported some heuristic results for finite populations. The key parameter governing how infinite populations evolve under FDMR is the curvature (k) of the relationship between fitness and mutation rate. We extend Agrawal's analysis to finite populations and consider dominance and epistasis. In finite populations, the probability of long‐term existence depends on k. In sexual populations, positive curvature leads to low equilibrium mutation rate, whereas negative curvature results in high mutation rate. In asexual populations, negative curvature results in rapid extinction via ‘mutational meltdown’, whereas positive curvature sometimes allows persistence. We speculate that fitness–dependent mutation rate may provide the conditions for genetic architecture to diverge between sexual and asexual taxa.
Cabibbo-allowed nonleptonic weak decays of charmed baryons.

Cabibbo-allowed nonleptonic weak decays of charmed baryons [Lambda][sub [ital c]][sup +], [Xi][sub [ital c]][sup 0[ital A]], [Xi][sub [ital c]][sup +[ital A]], and [Omega][sub [ital c]][sup 0] into an octet baryon and a pseudoscalar meson are analyzed. The nonfactorizable contributions are evaluated under the pole approximation, and it turns out that the [ital s]-wave amplitudes are dominated by the low-lying 1/2[sup [minus]] resonances, while [ital p]-wave ones are governed by the ground state 1/2[sup +] poles. The MIT bag model is employed to calculate the coupling constants, form factors, and baryon matrix elements. Our conclusions are the following: (i) [ital s] waves are no longer dominated by commutator terms; the current-algebra method is not applicable to parity-violating amplitudes. (ii) Nonfactorizable [ital W]-exchange effects are generally important; they can be comparable to and sometimes even dominate over factorizable contributions, depending on the decay modes under consideration. (iii) The large-[ital N][sub [ital c]] approximation for factorizable amplitudes also works in the heavy baryon sector and it accounts for the color nonsuppression of [Lambda][sub [ital c]][sup +][r arrow][ital p[bar K]][sup 0] relative to [Lambda][sub [ital c]][sup +][r arrow][Lambda][pi][sup +]. (iv) A measurement of the decay rate and the sign of the [alpha] asymmetry parametermore » of certain proposed decay modes will help discern various models. (v) [ital p] waves are the dominant contributions to the decays [Lambda][sub [ital c]][sup +][r arrow][Xi][sup 0][ital K+] and [Xi][sub [ital c]][sup 0[ital A]][r arrow][Sigma][sup +][ital K[minus]], but they are subject to a large cancellation; this renders present theoretical predictions on these two channels unreliable. « less
Bacterial removal from inexpensive portable water treatment systems for travelers.

BACKGROUND There are many personal portable water treatment systems for travelers on the market, including chemical agents, iodine resin purifiers and filters. However, information on the real efficacy of these systems in the field is often lacking. We have therefore estimated the capabilities of several inexpensive personal portable water treatment systems for travelers to remove bacteria in various situations of water quality, using stressed indigenous strains of bacteria. METHODS Four chemical agents (Drinkwell chlorine, Hydroclonazone, Aquatabs, 2% iodine in ethanol), two iodine resin purifiers (the straw PentaPure Outdoor M1-E, the PentaPure Traveler purifying and filtration system) and four filters (the flexible bottle Pres2Pure, the hand-pump filters Mini Ceramic, First Need Deluxe and WalkAbout) were evaluated in triplicate using both turbid and clear water at 25 degrees C. Bacteria were counted by conventional culturing techniques, colorimetric and fluorescent assays of coliforms and Escherichia coli enzyme activities (Colilert)/Quantitray method), and viable but not culturable bacteria were assessed quantitatively by 5-cyano-2,3-dilotyl-tetrazolium staining. RESULTS The best systems were the three hand-pump filters, Mini Ceramic, First Need Deluxe, and WalkAbout. All had a submicron filtration element that completely removed 3 log (99.9%) or more of viable bacteria, and no coliforms or E. coli were detected in the effluent. The PentaPure Traveler removed more than 99.3% of the viable bacteria. The only chemical agents that gave a bacterial inactivation of over 2 log in clear water were the Drinkwell chlorine, the Aquatabs, and the 2% iodine in ethanol. The three other devices, Hydroclonazone, Outdoor M1-E, and Pres2Pure, performed poorly, as coliforms and E. coli were detected in the treated water by the Colilert method. The chemical agents and the iodine resin straw performed poorly on raw river water; coliforms and E. coli were detected in the treated water. CONCLUSIONS These data demonstrate the differences between the systems tested. The effectiveness of other devices on the market should also be tested, so as to help travelers and hikers select the most appropriate portable water treatment system.
Postharvest Variation in Cell Wall-Degrading Enzymes of Papaya (Carica papaya L.) during Fruit Ripening.

Pectin methylesterase (PME), polygalacturonase (PG), xylanase, cellulase, and proteinase activity were determined and related to respiration, ethylene evolution, and changes in skin color of papaya (Carica papaya L.) fruit from harvest through to the start of fruit breakdown. PME gradually increased from the start of the climacteric rise reaching a peak 2 days after the respiratory peak. PG and xylanase were not detectable in the preclimacteric stage but increased during the climacteric: during the post climacteric stage, the PG declined to a level one-quarter of peak activity with xylanase activity returning to zero. Cellulase activity gradually increased 3-fold after harvest to peak at the same time as PME, 2 days after the edible stage. Proteinase declined throughout the climacteric and postclimacteric phases. A close relationship exists between PG and xylanase and the rise in respiration, ethylene evolution, and softening. Cultivar differences in postclimacteric levels of enzymic activity were not detected.An inhibitor of cellulase activity was detected in preclimacteric fruit. The inhibitor was not benzyl isothiocyanate (BITC). BITC did inhibit PG activity, though no inhibitor of PG activity was detected in preclimacteric homogenates when BITC was highest. The results indicate that inhibitors did not play a direct role in controlling wall softening.