Miracle-dz/UniFAR-FTUs huggingface dataset:
Compressed-domain video classification with deep neural networks: “There's way too much information to decode the matrix”

We investigate video classification via a 3D deep convolutional neural network (CNN) that directly ingests compressed bitstream information. This idea is based on the observation that video macroblock (MB) motion vectors (that are very compact and directly available from the compressed bitstream) are inherently capturing local spatio-temporal changes in each video scene. Our results on two standard video datasets show that our approach outperforms pixel-based approaches and remains within 7 percentile points from the best classification results reported by highly-complex optical-flow & deep-CNN methods. At the same time, a CPU-based realization of our approach is found to be more than 2500 times faster in the motion extraction in comparison to GPU-based optical flow methods and also offers 2 to 3.4-fold reduction in the utilized deep CNN weights compared to recent architectures. This indicates that deep learning based on compressed video bitstream information may allow for advanced video classification to be deployed in very large datasets using commodity CPU hardware. Source code is available at http://www.github. com/mvcnn.
Applying fuzzy theory and genetic algorithm to interpolate precipitation

A watershed management program is usually based on the results of watershed modeling. Accurate modeling results are decided by the appropriate parameters and input data. Rainfall is the most important input for watershed modeling. Precipitation characteristics, such as rainfall intensity and duration, usually exhibit significant spatial variation, even within small watersheds. Therefore, properly describing the spatial variation of rainfall is essential for predicting the water movement in a watershed. Varied circumstances require a variety of suitable methods for interpolating and estimating precipitation. In this study, a modified method, combining the inverse distance method and fuzzy theory, was applied to precipitation interpolation. Meanwhile, genetic algorithm (GA) was used to determine the parameters of fuzzy membership functions, which represent the relationship between the location without rainfall records and its surrounding rainfall gauges. The objective in the optimization process is to minimize the estimated error of precipitation. The results show that the estimated error is usually reduced by this method. Particularly, when there are large and irregular elevation differences between the interpolated area and its vicinal rainfall gauging stations, it is important to consider the effect of elevation differences, in addition to the effect of horizontal distances. Reliable modeling results can substantially lower the cost for the watershed management strategy. q 2005 Elsevier B.V. All rights reserved.
Lifetime reproductive success, selection on lifespan, and multiple sexual ornaments in male European barn swallows

Natural and sexual selection arise when individual fitness varies according to focal traits. Extra‐pair paternities (EPPs) can affect the intensity of selection by influencing variance in fitness among individuals. Studies of selection require that individual fitness is estimated using proxies of lifetime reproductive success (LRS). However, estimating LRS is difficult in large, open populations where EPPs cause reallocation of biological paternity. Here, we used extensive field sampling to estimate LRS in a population of barn swallows (Hirundo rustica) to estimate selection on lifespan and ornamental traits of males. We found selection on lifespan mediated both by within‐ and extra‐pair fertilization success and selection on tail length mediated by within‐ but not extra‐pair fertilization success. In addition, we found selection on tail white spots via extra‐pair fertilization success after controlling for selection on other traits. These results were not confounded by factors that hamper studies of LRS, including nonexhaustive sampling of offspring and biased sampling of males. Hence, natural and sexual selection mediated by LRS operates on lifespan, tail length, and size of the tail white spots in barn swallows.
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Targeting these pathways is often complex and can result in pathway activation depending on the presence of upstream mutations (e.g., Raf inhibitors induce Raf activation in cells with wild type (WT) RAF in the presence of mutant, activated RAS) and rapamycin can induce Akt activation. Targeting with inhibitors directed at two constituents of the same pathway or two different signaling pathways may be a more effective approach. This review will first evaluate potential uses of Raf, MEK, PI3K, Akt and mTOR inhibitors that have been investigated in pre-clinical and clinical investigations and then discuss how cancers can become insensitive to various inhibitors and potential strategies to overcome this resistance.
Copy-move forgery detection via texture description

Copy-move forgery is one of the most common type of tampering in digital images. Copy-moves are parts of the image that are copied and pasted onto another part of the same image. Detection methods in general use block-matching methods, which first divide the image into overlapping blocks and then extract features from each block, assuming similar blocks will yield similar features. In this paper we present a block-based approach which exploits texture as feature to be extracted from blocks. Our goal is to study if texture is well suited for the specific application, and to compare performance of several texture descriptors. Tests have been made on both uncompressed and JPEG compressed images.
Workability of Self-Compacting Concrete Using Blended Waste Materials

This paper presents the workability properties of Self-Compacting Concrete (SCC) containing a ternary mix binder using Ordinary Portland Cement and agro-industrial wastes i.e; palm oil fuel ash (POFA) and low calcium based fly ash (FA). The mixtures were prepared with 0 to 40% cement replacement using agro-industrial wastes at 10% intervals. Water to binder ratio and cement content is kept constant at 0.38 and 540 kg/m3 respectively. Self-compact-ability parameters investigated were Slump flow, J-Ring, V-Funnel, Sieve Stability and Visual Stability Index Tests. It is found that agro-industrial wastes provide a positive effect on the workability properties of self-compacting concrete.
Analysis of Japanese WSD with hiraganakanji conversion and context word embeddings

In this paper, we investigate a problem existing in Japanese word sense disambiguation (WSD) through a HiraganaKanji conversion task. In choosing words to consider as features, we propose a method that employs word embeddings and pointwise mutual information and evaluate the proposed method. The experimental results suggest that our method is more effective than other methods using word embeddings. We also compare the accuracy when changing the amount of training data. We find that the difference in accuracy between the methods becomes small when a very large amount of training data is used. We have confirmed that the method of improving accuracy while using fewer training data is important in WSD because the number of sentences required to obtain high accuracy increases exponentially.
A Low-Complexity Detection Scheme for Differential Spatial Modulation

Differential spatial modulation (DSM), which does not require the channel state information at the receiver, is an attractive alternative to its coherent counterpart. The optimal maximum-likelihood (ML) detector of the DSM system employs the classic block-by-block method for jointly detecting the activated antenna matrix (AM) and the modulation symbols, resulting in high computational complexity. In this letter, a low-complexity near-ML detector, which operates on a symbol-by-symbol basis, is proposed for the DSM scheme. Specifically, in each block, the index of the activated transmit antenna and modulation symbol in each time slot are first obtained, and then, these antenna indices are utilized to simply determine the index of the activated AM. Simulation results show that the proposed algorithm is capable of offering almost the same performance as that of the ML detector with more than 90% reduction in complexity.
Response to Therapy in Antiretroviral Therapy–Naive Patients With Isolated Nonnucleoside Reverse Transcriptase Inhibitor–Associated Transmitted Drug Resistance

Background: Nonnucleoside reverse transcriptase inhibitor (NNRTI)–associated transmitted drug resistance (TDR) is the most common type of TDR. Few data guide the selection of antiretroviral therapy (ART) for patients with such resistance. Methods: We reviewed treatment outcomes in a cohort of HIV-1–infected patients with isolated NNRTI TDR who initiated ART between April 2002 and May 2014. In an as-treated analysis, virological failure (VF) was defined as not reaching undetectable virus levels within 24 weeks, virological rebound, or switching regimens during viremia. In an intention-to-treat analysis, failure was defined more broadly as VF, loss to follow-up, and switching during virological suppression. Results: Of 3245 patients, 131 (4.0%) had isolated NNRTI TDR; 122 received a standard regimen comprising 2 NRTIs plus a boosted protease inhibitor (bPI; n = 54), an integrase strand transfer inhibitor (INSTI; n = 52), or an NNRTI (n = 16). The median follow-up was 100 weeks. In the as-treated analysis, VF occurred in 15% (n = 8), 2% (n = 1), and 25% (n = 4) of patients in the bPI, INSTI, and NNRTI groups, respectively. In multivariate regression, there was a trend toward a lower risk of VF with INSTIs than with bPIs (hazard ratio: 0.14; 95% confidence interval: 0.02 to 1.1; P = 0.07). In intention-to-treat multivariate regression, INSTIs had a lower risk of failure than bPIs (hazard ratio: 0.38; 95% confidence interval: 0.18 to 0.82; P = 0.01). Conclusions: Patients with isolated NNRTI TDR experienced low VF rates with INSTIs and bPIs. INSTIs were noninferior to bPIs in an analysis of VF but superior to bPIs when frequency of switching and loss to follow-up were also considered.
Does chronomodulated radiotherapy improve pathological response in locally advanced rectal cancer?

ABSTRACT The predominant mode of radiation-induced cell death for solid tumours is mitotic catastrophe, which is in part dependent on sublethal damage repair being complete at around 6 h. Circadian variation appears to play a role in normal cellular division, and this could influence tumour response of radiation treatment depending on the time of treatment delivery. We tested the hypothesis that radiation treatment later in the day may improve tumour response and nodal downstaging in rectal cancer patients treated neoadjuvantly with radiation therapy. Recruitment was by retrospective review of 267 rectal cancer patients treated neoadjuvantly in the Department of Radiation Oncology at the Canberra Hospital between January 2010 and November 2015. One hundred and fifty-five patients met the inclusion criteria for which demographic, pathological and imaging data were collected, as well as the time of day patients received treatment with each fraction of radiotherapy. Data analysis was performed using the Statistical Package R with nonparametric methods of significance for all tests set at p < 0.05. Of the 45 female and 110 male patients, the median age was 64. Seventy-three percent had cT3 disease and there was a mean tumour distance from the anal verge of 7 cm. Time to surgical resection following radiotherapy ranged from 4 to 162 days with a median of 50 days, with a complete pathological response seen in 21% of patients. Patients exhibiting a favourable pathological response had smaller median pre- and postradiotherapy tumour size and had a greater change in tumour size following treatment (p < 0.01). Patients who received the majority of their radiotherapy fractions after 12:00 pm were more likely to show a complete or moderate pathological response (p = 0.035) and improved nodal downstaging. There were also more favourable responses amongst patients with longer time to surgical resection postradiotherapy (p < 0.004), although no relationship was seen between response and tumour distance from the anal verge. Females were less likely to exhibit several of the above responses. Neoadjuvant radiotherapy for locally advanced rectal cancer performed later in the day coupled with a longer time period to surgical resection may improve pathological tumour response rates and nodal downstaging. A prospective study in chronomodulated radiotherapy in this disease is warranted.
Differentiation of Benign Fluid Collections from Soft-Tissue Sarcomas on FDG-PET/CT

Objective: To assess the diagnostic performance of 18F-FDG PET-CT in differentiating soft tissue sarcomas (STSs) from benign fluid collections (BFs). Materials and methods: Four readers independently reviewed 100 lesions on 18F-FDG PET-CT and subjectively classified each lesion as an STS or BF and scored the spatial pattern of 18F-FDG avidity (SP) of each on a 4-point ordered scale (thin, moderate, thick, solid). Results: Subjective assessment by readers allowed sensitive (91%-98%) differentiation of STSs from BFs, with lower specificity (59%-91%). The STSs had significantly higher SUVmax (median 10.7, range: 2.0-33.7) than BFs (median 2.8, range: 1.1-12.3). Reader agreement in assessment of SP had average κ = 0.61 (range 0.46-0.70). Classification of thick or solid SP as STS yielded an inter-reader averaged sensitivity and specificity of 69% and 98%, respectively. The presence of thick or solid SP resulted in 14.1-fold increase in partial odds of STS. Each unit increase in SUVmax resulted in 1.35-fold increase in partial odds of STS. The receiver operating characteristic (ROC) curves and 95% intervals for SUVmax alone and SUVmax + SP overlapped. The average subjective assessments for the four readers and estimated performance of using SP alone were both contained within the 95% intervals of the two ROC curves. Conclusions: 18F-FDG PET-CT is a sensitive modality for differentiating STSs from BFs. SUVmax and SP are significantly associated with STS. Classification schemes based upon SUVmax alone or augmented with SP can be useful for distinguishing STS from BF.
Is there a role for traditional nuclear medicine imaging in the management of pulmonary carcinoid tumours?†

OBJECTIVES The clinical utility of fluorodeoxyglucose-positron emission tomography (FDG-PET) and somatostatin receptor scintigraphy (SRS) in pulmonary carcinoids staging is unclear. This study aims to determine the role of FDG-PET and SRS in detecting hilar-mediastinal lymph node metastasis from these tumours. METHODS We retrospectively collected the data of 380 patients who underwent lung resection for primary pulmonary carcinoid in seven centres between 2000 and 2015. Patients without nodal sampling ( n = 78) were excluded. In 302 patients [35% men, median age 58 (interquartile range 47-68) years] the results of preoperative computed tomography (CT) scan, FDG-PET and SRS were analysed and compared to the pathological findings after resection to determine the respective utility of these two nuclear tests. RESULTS The sensitivity, specificity and negative predictive value in detecting N1 and N2 disease were respectively 33% and 46%, 93% and 90%, 88% and 95% for computed-tomography-scan, 38% and 60%, 93% and 95%, 88% and 95% for FDG-PET, 22% and 33%, 95% and 98%, 84% and 87% for SRS. The diagnostic accuracy for N1 and N2 disease of CT scan was not significantly different from that of FDG-PET ( P = 1.0 and P = 0.37 for N1 and N2 disease respectively) and of SRS ( P = 0.47 and P = 0.35 for N1 and N2 disease respectively). The sensitivity and specificity of these imaging tests were also similar when analysed by typical vs atypical histology. CONCLUSIONS CT scan, FDG-PET and SRS showed similar performance in terms of nodal staging for pulmonary carcinoid. These findings suggest that additional nuclear imaging beyond CT scan is not required as long as a lymphadenectomy or nodal sampling is completed at resection.
Effects of fibroblasts on the function of acinar cells from the same human parotid gland

Artificial salivary gland replacement would be an ideal treatment for xerostomia. In vivo, salivary gland cells are surrounded by a complex stromal environment in which fibroblasts are the main cell type in proximity to the gland cells. However, very little is known about the relationship between these fibroblasts and the gland cells.
Substitution with Alternative Anti-TNF&agr; Therapy (SAVANT)—Outcomes of a Crohn's Disease Cohort Undergoing Substitution Therapy with Certolizumab

Background:Biological therapy targeting tumor necrosis factor-alfa has revolutionized the treatment of Crohn's disease (CD). Our study retrospectively reviewed clinical outcomes of 60 patients administratively substituted from Infliximab or Adalimumab to Certolizumab. Maintenance of disease and failure rates after substitution of anti–tumor necrosis factor-alfa agents in CD patients were monitored over 1 year, and this is the first outcomes study of patients maintained on Infliximab or Adalimumab substituted to Certolizumab. Methods:A hospital pharmacy directive required all patients on biological therapy to be administratively substituted to Certolizumab therapy. This single-center retrospective analysis initially included 68 CD patients presenting at Louisiana State University Health Sciences Center-Shreveport. Clinical, endoscopic, and serologic data were compared at baseline and at 4 intervals over 1 year. Results:Of 60 enrolled CD patients, 45 (75%) successfully transitioned to Certolizumab and had stable disease at 1 year. Of the 15 (25%) patients who “failed” substitution at 1 year, 5 were returned to Adalimumab and 7 to Infliximab; 3 were maintained on steroids awaiting subsequent therapy. Importantly, when patients were segregated on the basis of initial disease control, it was found that 3 (12.5%) previously well-controlled patients failed therapy, whereas 12 (33.3%) who initially had active disease failed Certolizumab substitution. Conclusions:Our study found that 25% of CD patients substituted to Cimzia failed substitution, whereas 75% still exhibited a good clinical response with stable disease at 1 year. Our findings indicate that disease status and behavior at the time of biological substitution may predict therapeutic responsiveness.
Expressive disclosure to improve well-being in patients with amyotrophic lateral sclerosis: A randomised, controlled trial

Amyotrophic lateral sclerosis (ALS) is a terminal neurological disease associated with progressive paralysis, loss of communicative ability and functional decline. Expressive disclosure may help people with ALS, particularly those who are emotionally or socially inhibited, meet psychological challenges associated with the disease. People with ALS (N = 48) were randomised to expressive disclosure about their disease or no disclosure. Psychological well-being (affect, depression and quality of life) was assessed pre-intervention and also three and six months later. Results of multi-level models indicated that the group that disclosed thoughts and feelings about ALS had higher well-being than the control group at three months post-intervention, but not six months. Ambivalence over emotional expression (AEE) moderated three-month post-intervention well-being. Those low in AEE had higher well-being than those high in AEE regardless of condition. Those high in AEE, who disclosed, had increased well-being from pre-intervention, whereas controls had decreased well-being from pre-intervention. Expressive disclosure may be helpful for people with ALS, but only those who have difficulty expressing emotions. In addition, the intervention had only temporary effects; the dynamic challenges of ALS progression may mean that the effect of processing thoughts and feelings about the disease in one stage may not generalise to later stages.
Plasma glial cell line-derived neurotrophic factor in patients with major depressive disorder: a preliminary study

Background Some clinical studies have reported reduced peripheral glial cell line-derived neurotrophic factor (GDNF) level in elderly patients with major depressive disorder (MDD). We verified whether a reduction in plasma GDNF level was associated with MDD. Method Plasma GDNF level was measured in 23 healthy control subjects and 23 MDD patients before and after 6 weeks of treatment. Results Plasma GDNF level in MDD patients at baseline did not differ from that in healthy controls. Plasma GDNF in MDD patients did not differ significantly from baseline to the end of treatment. GDNF level was significantly lower in recurrent-episode MDD patients than in first-episode patients before and after treatment. Conclusions Our findings revealed significantly lower plasma GDNF level in recurrent-episode MDD patients, although plasma GDNF levels in MDD patients and healthy controls did not differ significantly. The discrepancy between our study and previous studies might arise from differences in the recurrence of depression or the ages of the MDD patients.
Environmental Stress-Dependent Effects of Deletions Encompassing Hsp70Ba on Canalization and Quantitative Trait Asymmetry in Drosophila melanogaster

Hsp70 genes may influence the expression of wing abnormalities in Drosophila melanogaster but their effects on variability in quantitative characters and developmental instability are unclear. In this study, we focused on one of the six Hsp70 genes, Hsp70Ba, and investigated its effects on within-and among-individual variability in orbital bristle number, sternopleural bristle number, wing size and wing shape under different environmental conditions. To do this, we studied a newly constructed deletion, Df(3R)ED5579, which encompasses Hsp70Ba and nine non-Hsp genes, in the heterozygous condition and another, Hsp70Ba304, which deletes only Hsp70Ba, in the homozygous condition. We found no significant effect of both deletions on within-individual variation quantified by fluctuating asymmetry (FA) of morphological traits. On the other hand, the Hsp70Ba304/Hsp70Ba304 genotype significantly increased among-individual variation quantified by coefficient of variation (CV) of bristle number and wing size in female, while the Df(3R)ED5579 heterozygote showed no significant effect. The expression level of Hsp70Ba in the deletion heterozygote was 6 to 20 times higher than in control homozygotes, suggesting that the overexpression of Hsp70Ba did not influence developmental stability or canalization significantly. These findings suggest that the absence of expression of Hsp70Ba increases CV of some morphological traits and that HSP70Ba may buffer against environmental perturbations on some quantitative traits.