Miracle-dz/UniFAR-FTUs huggingface dataset:
Community Detection in Multi-Dimensional Networks

Abstract : The pervasiveness of Web 2.0 and social networking sites has enabled people to interact with each other easily through various social media. For instance, popular sites like Del.icio. us, Flickr, and YouTube allow users to comment on shared content (bookmarks, photos, videos), and users can tag their favorite content. Users can also connect with one another, and subscribe to or become a fan or a follower of others. These diverse activities result in a multi-dimensional network among actors, forming group structures with group members sharing similar interests or a liations. This work systematically addresses two challenges. First, it is challenging to e ectively integrate interactions over multiple dimensions to discover hidden community structures shared by heterogeneous interactions. We show that representative community detection methods for single-dimensional networks can be presented in a uni- ed view. Based on this uni ed view, we present and analyze four possible integration strategies to extend community detection from single-dimensional to multi-dimensional networks. In particular, we propose a novel integration scheme based on structural features. Another challenge is the evaluation of different methods without ground truth information about community membership. We employ a novel cross-dimension network validation procedure to compare the performance of di erent methods. We use synthetic data to deepen our understanding, and real-world data to compare integration strategies as well as baseline methods in a large scale. We study further the computational time of di erent methods, normalization e ect during integration, sensitivity to related parameters, and alternative community detection methods for integration.
Addressing student cheating: definitions and solutions

1 Monash University, Australia email: martin.dick, judy.sheard}@csse.monash. edu.au 2 Olivet Nazarene University, USA email: cbareiss@olivet.edu 3 University of Kent at Canterbury, UK email: j.e. carter@ukc.ac. uk 4 UNITEC Institute of Technology, New Zealand email: djoyce@unitec.ac. nz 5 Kettering University, USA email: tharding@kettering.edu 6 Rose-Hulman Institute of Technology, USA email: laxer@rose-hulman.edu
RXJ2115-5840: confirmation of a new near-synchronous Polar

Following the suggestion of Schwope et al. that the magnetic cataclysmic variable RX J2115--5840 may be a near-synchronous polar, we obtained optical polarimetry of this system over a 2-week period. From a power spectrum of the circular polarimetry data we determine that the spin period of the white dwarf and the binary orbital period differ by 1.2 per cent. RX J2115--5840 is thus the fourth near-synchronous polar and has the shortest spin--orbit beat period: 6.3 d. By folding the data on spin, beat and orbital periods we find evidence that the accretion stream is directed towards opposite magnetic poles as the stream precesses around the white dwarf on the spin--orbit beat period. The phasing requires that the accretion flow must be directed on to the same magnetic field line at all spin--orbit beat phases, implying that at some phases the flow must follow a path around the white dwarf before accreting. This is difficult to reconcile with simple views of how the accretion stream attaches on to the magnetic field of the white dwarf.
BIOEQUIVALENCE COMPARISON OF TWO DRUG‐IN-ADHESIVE TRANSDERMAL NITROGLYCERIN PATCHES

Plasma concentrations of nitroglycerin, 1, 2-dinitroglycerin and 1, 3-dinitroglycerin in 50 healthy male subjects who received single 24-h applications of two 0.6 mg /h drug-in-adhesive transdermal nitroglycerin patch formulations were compared for the purpose of establishing bioequivalence. The rates of appearance and elimination of nitroglycerin and both dinitro metabolites were the same for both patch treatments. The pharmacokinetic and statistical analyses indicated that the 20-cm2 test patch met the current two one-sided t-test criteria for bioequivalence with the 30-cm2 reference patch for nitroglycerin and both dinitro metabolites, even though the reference patch was 50% larger in size and contained 120% more nitroglycerin than the test patch. A likely explanation for the equivalence in drug delivery with a smaller patch is that the test patch maintained more intimate skin contact than did the reference patch. This study shows that strict bioequivalence criteria can be met with a highly variable drug such as nitroglycerin.
IMAGE MINING FOR ESTABLISHING MEDICAL DIAGNOSIS

In this paper, a method based on association rules that support medical image diagnosis is developed. The proposed method has important characteristics that make it different from other computer assisted diagnosis methods: the process is completely automatic, having the possibility to define a great number of diagnoses; the method could be applied to any medical domain, because the visual features, the semantic indicators remain unchangeable, and the semantic rules are generated by learning from labelled images-examples; the selection of the visual characteristics set is based on their retrieval accuracy; the spatial information of the regions is considered, offering important medical information of the relationships between sick regions. Although we present the results achieved in endoscopic images analysis, our method can be used to analyze other types of medical images. The prototype system was applied to real datasets and the results show high accuracy.
Delayed Posttraumatic Acute Subdural Hematoma in Elderly Patients on Anticoagulation

OBJECTIVE:To discuss delayed acute subdural hematoma (DASH), a relatively neglected entity, and to emphasize the potentially elevated risk for DASH among elderly, anticoagulated mild traumatic brain injury (TBI) patients. METHODS:The authors reviewed clinical and radiological data for four patients who had normal neurological examinations and normal computed tomographic scans after mild TBI, and who subsequently developed DASH and deteriorated rapidly. RESULTS:The patients included two men and two women, aged 65 to 86 years, who presented to the emergency department after mild TBI between January 2002 and June 2004. All were treated with chronic anticoagulation or anti-aggregation therapy. They deteriorated owing to DASH from 9 hours to 3 days after TBI. Three of the four patients underwent craniotomy for evacuation of their hematomas. One patient, who suffered only focal neurological deficit, was treated conservatively, and her hematoma gradually resolved. Two patients died and two reached Glasgow Outcome Scores of 3 and 4 after extended inpatient rehabilitation. CONCLUSION:A suspicion of DASH should be raised in elderly, anticoagulated, mild TBI patients, including those who present to the emergency department with Glasgow Coma Scores of 15 and normal computed tomographic scans after injury. Based on our experience, we recommend that elderly, anticoagulated mild TBI patients should be admitted for 24 to 48 hours of observation after injury.
Order Flow and Prices

We provide new evidence on the relation between order flow and prices, an issue that is central to asset pricing and market microstructure. We examine proprietary data on a broad panel of NYSE-listed stocks that reveal daily order imbalances by institutions, individuals, and market makers. We can further differentiate regular institutional trades from institutional program trades. Our results indicate that order imbalances from different trader types play distinctly different roles in price formation. Institutions and individuals are contrarians with respect to previous-day returns, but differ in the effect their order imbalances have on contemporaneous returns. Institutional imbalances are positively related to contemporaneous returns, and we provide cross-sectional evidence that this relation is likely to be the result of firm-specific information institutions have. Individuals, specialists, and other market makers appear to provide liquidity to these actively trading institutions. Our results also suggest a special role for institutional program trades, which tend to be uninformed and provide liquidity to more aggressively trading institutions. Finally, institutional non-program imbalances (information which is not available to market participants) have predictive power for next-day returns.
Characterization of a novel transcriptionally active domain in the transforming growth factor β-regulated Smad3 protein

Transforming growth factor β (TGFβ) regulates transcriptional responses via activation of cytoplasmic effector proteins termed Smads. Following their phosphorylation by the type I TGFβ receptor, Smads form oligomers and translocate to the nucleus where they activate the transcription of TGFβ target genes in cooperation with nuclear cofactors and coactivators. In the present study, we have undertaken a deletion analysis of human Smad3 protein in order to characterize domains that are essential for transcriptional activation in mammalian cells. With this analysis, we showed that Smad3 contains two domains with transcriptional activation function: the MH2 domain and a second middle domain that includes the linker region and the first two β strands of the MH2 domain. Using a protein–protein interaction assay based on biotinylation in vivo, we were able to show that a Smad3 protein bearing an internal deletion in the middle transactivation domain is characterized by normal oligomerization and receptor activation properties. However, this mutant has reduced transactivation capacity on synthetic or natural promoters and is unable to interact physically and functionally with the histone acetyltransferase p/CAF. The loss of interaction with p/CAF or other coactivators could account, at least in part, for the reduced transactivation capacity of this Smad3 mutant. Our data support an essential role of the previously uncharacterized middle region of Smad3 for nuclear functions, such as transcriptional activation and interaction with coactivators.
Risk factors for hemoptysis complicating 17-18 gauge CT-guided transthoracic needle core biopsy: multivariate analysis of 249 procedures.

PURPOSE We aimed to identify modifiable and nonmodifiable risk factors for hemoptysis complicating computed tomography (CT)-guided transthoracic needle biopsy. METHODS All procedures performed in our institution from November 2013 to May 2015 were reviewed. Hemoptysis was classified as mild if limited to hemoptoic sputum and abundant otherwise. Presence of intra-alveolar hemorrhage on postbiopsy CT images was also evaluated. Patient- and lesion-related variables were considered nonmodifiable, while procedure-related variables were considered modifiable. RESULTS A total of 249 procedures were evaluated. Hemoptysis and alveolar hemorrhage occurred in 18% and 58% of procedures, respectively, and were abundant or significant in 8% and 17% of procedures, respectively. Concordance between the occurrence of significant alveolar hemorrhage (grade ≥2) and hemoptysis was poor (κ=0.28; 95% CI [0.16-0.40]). In multivariate analysis, female gender (P = 0.008), a longer transpulmonary needle path (P = 0.014), and smaller lesion size (P = 0.044) were independent risk factors for hemoptysis. Transpulmonary needle-path length was the only risk factor for abundant hemoptysis with borderline statistical significance (P = 0.049). CONCLUSION The transpulmonary needle path should be as short as possible to reduce the risk of abundant hemoptysis during CT-guided transthoracic needle biopsy.
Contrast-enhanced ultrasound with SonoVue could accurately assess the renal microvascular perfusion in diabetic kidney damage.

OBJECTIVE The aim of this study was to investigate the clinical significance of real-time gray-scale contrast-enhanced ultrasound (CEUS) through evaluating renal microvascular perfusion in diabetic kidney damage. METHODS Diabetic patients (aged: 62.5±7.2, n=33) were divided into Group A with chronic kidney disease (CKD) Stages I and II (n=19) and Group B (n=14) with CKD Stages IV and V. Twenty-one healthy adults were selected as control group. The real-time and dynamic imaging from renal cortex was performed using contrast-enhanced ultrasound with SonoVue. The outage time-intensity curves (TICs) with >85% goodness-of-fit index were chosen for the analysis of basic intensity, intensity increment (A1), arriving time (AT), time to peak (TTP), mean transit time, peak intensity (PI) and total area under the curve (AUC). RESULTS (i) After intravenous injection of a contrast agent, the renal artery, cortex, pyramid and renal vein were clearly displayed in sequence. (ii) TIC of renal cortical Perfusion in all groups showed an asymmetrical single-peak curve, which has an obvious ascending slope, peak and descending slope. The ascending slope was steep, whereas the descending slope was flat. However, the ascending slope in Group A and B was flatter than that in the control group. (iii) Compared to the control group, AT and TTP were all markedly prolonged but A1 and PI were significantly decreased in Group A and B (P<0.05). In Group A, the AUC had a trend of increase; however, the area under the ascending slope (AUC1), area under the descending slope (AUC2) and AUC were all decreased in Group B (P<0.05). (iv) AUC positively correlated with glomerular filtration rate (GFR) (r=0.472, P=0.01), but TTP did not correlate well with GFR (r=0.262, P=0.177). CONCLUSIONS CEUS could accurately assess renal microvascular perfusion in a real-time and dynamic manner. PI, TTP and AUC could be used for the diagnosis of the renal microvascular damage in early and late stage diabetic patients. CEUS is a safe, noninvasive and simple technique to detect the severity of kidney microvascular perfusion deficits.
Trends in Alcohol Consumption Among Undergraduate Students at a Northeastern Public University, 2002–2008

Abstract Objective: This study examined alcohol consumption patterns and trends at a public university in the Northeast from 2002 to 2008. Participants: Stratified random sampling was used to select undergraduate students enrolled in courses during spring semesters in 2002, 2004, 2006, and 2008. Methods: Data were collected during regularly scheduled classes for 4 measures of alcohol consumption and 5 demographic categories using the Core Alcohol and Drug Survey. Results: Four groups showed significant increases in both frequency and volume of alcohol consumption—students who were female, over 21 years of age or over, living off-campus, or performing well academically. There were no decreasing trends for any demographic group. These results differ from national college health surveys, which have shown alcohol use remaining steady during this period. Conclusions: Campus-specific trend data can provide unique perspectives and guide programming efforts. These trends suggest a need for new intervention strategies on this campus.
Effect of Titanium Addition on As Cast Structure and Macrosegregation of High‐Carbon High‐Chromium Steel

In casting heavy ingots of high‐chromium high‐carbon cold work steels, macrosegregation develops in the center of the ingot, causing difficulties during subsequent hot working. Heat transfer and solidification of an industrial scale high‐carbon high‐chromium steel ingot was simulated and thereafter a laboratory scale representative ingot was designed to model the solidification of the industrial scale ingot. Titanium in the range of 0.3–1% was added to the high‐chromium high‐carbon (12%Cr–2%C) steel during melting process. Microstructures, macrosegregation and phase formations were studied using optical microscopy, scanning electron microscopy, energy dispersive X‐ray spectrometry, wave dispersive X‐ray spectrometry, optical emission spectroscopy, and X‐ray diffraction. Addition of 0.3% titanium was sufficient to diminish the macrosegregation; however it did not have a significant effect on the grain size. Addition of 0.7 and 1% titanium had a substantial effect on grain size in the longitudinal direction and refined the primary carbides structure. The formation of small TiC carbides that precipitated before solidification of liquid iron acted as nuclei for primary pro‐eutectic austenite grains.
Betting Against Beta

We present a model in which some investors are prohibited from using leverage and other investors' leverage is limited by margin requirements. The former investors bid up high-beta assets while the latter agents trade to profit from this, but must de-lever when they hit their margin constraints. We test the model's predictions within U.S. equities, across 20 global equity markets, for Treasury bonds, corporate bonds, and futures. Consistent with the model, we find in each asset class that a betting-against-beta (BAB) factor which is long a leveraged portfolio of low-beta assets and short a portfolio of high-beta assets produces significant risk-adjusted returns. When funding constraints tighten, betas are compressed towards one, and the return of the BAB factor is low.
Serum vitamin B12 and transcobalamin abnormalities in patients with cancer

One hundred and thirty‐nine patients with non‐hematologic malignancy were studied to define the incidence of vitamin B12‐related abnormalities and correlate them with clinical findings. Based on vitamin B12‐binding patterns, the following relatively distinct groups were defined: (A) 50% had normal results; (B) 6% had very high transcobalamin (TC) I and vitamin B12 levels as reported in isolated instances previously: most had hepatic metastases and early death, and all had definite metastatic disease; (C) 11% had high vitamin B12 levels with little or no unsaturated TC I elevation: most also had hepatic and other metastases and early death; (D) 23% had high vitamin B12‐binding capacity with normal TC I and vitamin B12 levels: there were no distinguishing features for this group other than an increased proportion of black patients; and (E) 10% had low vitamin B12 levels, in many cases not associated with vitamin B12 deficiency or other known causes of low serum levels. Thus, high serum vitamin B12 level, with or without unsaturated TC I elevation, usually implies a poor prognosis in a patient with cancer. However, while most such patients have hepatic and other metastases, hepatic involvement was not universal nor did most patients with hepatic disease have high vitamin B12 levels. High serum TC I thus is not always due to increased granulocytic proliferation or to hepatic tumor, and alternative mechanisms for TC I accumulation should be sought.
Obstructive Sleep Apnea Syndrome Affects Left Ventricular Diastolic Function: Effects of Nasal Continuous Positive Airway Pressure in Men

Background—The purpose of this study was to determine the role of obstructive sleep apnea syndrome (OSAS) as an independent risk factor for the development of left ventricular diastolic abnormalities. Moreover, we tested the hypothesis that nasal continuous positive airway pressure (nCPAP) improves such alterations in OSAS patients by eliminating apneic events. Methods and Results—In this prospective, randomized, placebo-controlled, double-blind crossover study, 27 consecutive newly diagnosed middle-aged OSAS men with neither controllable factors nor conditions affecting left ventricular diastolic function and 15 healthy control subjects were selected. OSAS patients were randomized to 12 weeks on sham nCPAP and 12 weeks on effective nCPAP application. Echocardiographic parameters, blood pressure recordings, and urinary catecholamine levels were obtained at baseline and after both treatment modalities. At baseline, an abnormal left ventricular filling pattern was present in 15 of the 27 OSAS patients and only in 3 of the 15 control subjects (P=0.020). Impaired relaxation was by far the most common abnormal pattern in both groups (11 and 3 patients, respectively). In OSAS patients, 12 weeks on effective nCPAP induced a significant increase in E/A ratio (P<0.01), as well as reductions in mitral deceleration (P<0.01) and isovolumic relaxation (P<0.05) times. Conclusions—OSAS can affect left ventricular diastolic function independently of other possible factors. Chronic application of nCPAP could avoid the progression of diastolic abnormalities, and indeed, it might reverse these alterations, at least in the initial stages before severe structural changes can be developed.
p53 Amino-Terminus Region (1–125) Stabilizes and Restores Heat Denatured p53 Wild Phenotype

Background The intrinsically disordered N-ter domain (NTD) of p53 encompasses approximately hundred amino acids that contain a transactivation domain (1–73) and a proline-rich domain (64–92) and is responsible for transactivation function and apoptosis. It also possesses an auto-inhibitory function as its removal results in remarkable reduction in dissociation of p53 from DNA. Principal Findings/Methodology In this report, we have discovered that p53-NTD spanning amino acid residues 1–125 (NTD125) interacted with WT p53 and stabilized its wild type conformation under physiological and elevated temperatures, both in vitro and in cellular systems. NTD125 prevented irreversible thermal aggregation of heat denatured p53, enhanced p21-5′-DBS binding and further restored DBS binding activity of heat-denatured p53, in vitro, in a dose-dependent manner. In vivo ELISA and immunoprecipitation analysis of NTD125-transfected cells revealed that NTD125 shifted equilibrium from p53 mutant to wild type under heat stress conditions. Further, NTD125 initiated nuclear translocation of cytoplasmic p53 in transcriptionally active state in order to activate p53 downstream genes such as p21, Bax, PUMA, Noxa and SUMO. Conclusion/Significance Here, we showed that a novel chaperone-like activity resides in p53-N-ter region. This study might have significance in understanding the role of p53-NTD in p53 stabilization, conformational activation and apoptosis under heat-stress conditions.
Amyloplast Membrane Protein SUBSTANDARD STARCH GRAIN6 Controls Starch Grain Size in Rice Endosperm1

Starch grain size is an important factor for industrial applications of starch and is affected by a novel amyloplast membrane protein. Starch is a biologically and commercially important polymer of glucose. Starch is organized into starch grains (SGs) inside amyloplasts. The SG size differs depending on the plant species and is one of the most important factors for industrial applications of starch. There is limited information on genetic factors regulating SG sizes. In this study, we report the rice (Oryza sativa) mutant substandard starch grain6 (ssg6), which develops enlarged SGs in endosperm. Enlarged SGs are observed starting at 3 d after flowering. During endosperm development, a number of smaller SGs appear and coexist with enlarged SGs in the same cells. The ssg6 mutation also affects SG morphologies in pollen. The SSG6 gene was identified by map-based cloning and microarray analysis. SSG6 encodes a protein homologous to aminotransferase. SSG6 differs from other rice homologs in that it has a transmembrane domain. SSG6-green fluorescent protein is localized in the amyloplast membrane surrounding SGs in rice endosperm, pollen, and pericarp. The results of this study suggest that SSG6 is a novel protein that controls SG size. SSG6 will be a useful molecular tool for future starch breeding and applications.