Miracle-dz/UniFAR-FTUs huggingface dataset:
THE RELATIONSHIPS BETWEEN PSYCHOLOGICAL CONTRACT, ORGANIZATIONAL CYNICISM AND TURNOVER INTENTION

Aim. Hospital establishments are complex structures that embody various business fields. That is why the attitudes of employees towards organization can be affected positively or negatively. If this effect is negative, the employees can display insulting and ironical negative attitudes and can cause cynical attitudes and psychological breach of contract. This situation can increase the turnover intention. The aim of this research is to identify the effects of organizational cynicism and psychological contract subdimensions on turnover intention. Method . The employees (N=324) of a state hospital in Tokat (Turkey) province were included this study and the datas were obtained by using survey method. In order to test hypotheses correlation and regression analysis. Findings. In the study the effect of organizational cynicism subdimensions on turnover intention was not found significant (p>0,05), however the effect of operational psychological contract which is subdimension of psychological contract on turnover intention was found positive and significant (H2a:β=0,191,p<0,01). Besides, it was determined that the operational psychological contract had a positive and significant effect on organizational cynicism (H3a:β=0, 279,p<0,01). Whereas, it was detected that the effect of relational psychological contract on organizational cynicism was negative and significant (H3b:β=-0,413,p<0,01). Results . The conclusion is that at the end of the study, operational psychological contract had positive effect on the turnover intention and organizational cynicism.
Impaired thrombolysis: a novel cardiovascular risk factor in end-stage renal disease.

AIMS End-stage renal disease (ESRD) patients have an excess cardiovascular risk, above that predicted by traditional risk factor models. Prothrombotic status may contribute to this increased risk. Global thrombotic status assessment, including measurement of occlusion time (OT) and thrombolytic status, may identify vulnerable patients. Our aim was to assess overall thrombotic status in ESRD and relate this to cardiovascular risk. METHODS AND RESULTS Thrombotic and thrombolytic status of ESRD patients (n = 216) on haemodialysis was assessed using the Global Thrombosis Test. This novel, near-patient test measures the time required to form (OT) and time required to lyse (lysis time, LT) an occlusive platelet thrombus. Patients were followed-up for 276 ± 166 days for major adverse cardiovascular events (MACE, composite of cardiovascular death, non-fatal MI, or stroke). Peripheral arterial or arterio-venous fistula thrombosis was a secondary endpoint. Occlusion time was reduced (491 ± 177 vs. 378 ± 96 s, P < 0.001) and endogenous thrombolysis was impaired (LT median 1820 vs.1053 s, P < 0.001) in ESRD compared with normal subjects. LT ≥ 3000 s occurred in 42% of ESRD patients, and none of the controls. Impaired endogenous thrombolysis (LT ≥ 3000 s) was strongly associated MACE (HR = 4.25, 95% CI = 1.58-11.46, P = 0.004), non-fatal MI and stroke (HR = 14.28, 95% CI = 1.86-109.90, P = 0.01), and peripheral thrombosis (HR = 9.08, 95% CI = 2.08-39.75, P = 0.003). No association was found between OT and MACE. CONCLUSION Impaired endogenous thrombolysis is a novel risk factor in ESRD, strongly associated with cardiovascular events.
International Conference on Intelligent and Advanced Systems 2007 on Optimal Parameter Selection for Multiresolution Based Image Watermarking

Although many researches have been devoted to the development of proper watermarking procedures using multiresolution-based transformation, most of these investigations encounter watermarking problems from a specific point of view. Therefore, there is a lack of a general investigation dedicated to the study of parameter selections and their impacts on the transparency and robustness of the final watermarked image. In this paper, common and different filter banks used for decomposition of two dimensional signals, the depth of data embedding with respect to wavelet decomposition levels and of course the impact of these parameters on the robustness of algorithms are studied to find the optimum conditions for watermarking procedures.
Harmonic Detection By Using Different Artificial Neural Network Topologies

At this paper the performance of different artificial neural networks (ANN) topologies has been analized for harmonic detection by distorted waveforms. With this information, it’s possible to obtain the reference signal for an active power filter (APF) control by nonlinear loads compensation. In particular, two ANN types, the static multilayer perceptron (MLP) and the dynamic MLP, stand out as the most suitable for distorsion identifying. Acceptable results were also obtained with recurrent networks, but with a lower performance than with the other topologies. Two different control strategies have been applied. One of them is based in the static MLP, neural network that has proved to be the most appropiate by measuring the rectangular components of the signal harmonics. The other strategy, based in the dynamic MLP, permits extracting the instantaneous value of the fundamental waveform. The three mentioned ANN topologies have been conveniently trained and simulated with waveforms distorted by several harmonics. Finally, the obtained results with practical cases of harmonic distorted waveforms are presented and discussed.
The Optimality of Being Efficient

In an optimal auction, a revenue-optimizing seller often awards goods inefficiently, either by placing them in the wrong hands or by withholding goods from the market. This conclusion rests on two assumptions: (1) the seller can prevent resale among bidders after the auction; and (2) the seller can commit to not sell the withheld goods after the auction. We examine how the optimal auction problem changes when these assumptions are relaxed. In sharp contrast to the no resale assumption, we assume perfect resale: all gains from trade are exhausted in resale. In a multiple object model with independent signals, we characterize optimal auctions with resale. We prove generally that with perfect resale, the seller's incentive to misassign goods is destroyed. Moreover, with discrete types, any misassignment of goods strictly lowers the seller's revenue from the optimum. In auction markets followed by perfect resale, it is optimal to assign goods to those with the highest values.
Tumor Transplantation Model Myeloid-Derived Suppressor Cells in a 4T1 Responses through Inhibition of Host B7-H4 Regulates Antitumor T Cell

B7-H4, a member of the B7 family of T cell immunomodulatory proteins, has been shown to inhibit T cell responses and neutrophil expansion during bacterial infections. However, the role of B7-H4 in the immune response during tumor growth has been unclear. In this study, we examined the host immune responses in B7-H4–deﬁcient (knockout [KO]) or sufﬁcient (wild-type [WT]) BALB/cJ mice upon transplantation of murine 4T1 carcinoma cells that had little B7-H4 expression. We reveal that host B7-H4 not only dampens the antitumor Th1 responses, but also inhibits the protumor function of myeloid-derived suppressor cells (MDSC). We observed increased expression of both antitumor immune effectors and protumor MDSC-associated transcripts in 4T1 tumors grown in B7-H4 KO mice compared with those grown in WT hosts. Consistently, MDSCs derived from B7-H4 KO mice suppressed T cell proliferation more potently than their WT counterparts. Although the primary growth of 4T1 tumors in B7-H4 KO hosts was similar to that in WT mice, tumors that had grown in B7-H4 KO hosts grew much slower than those from WT mice when subsequently transplanted into WT hosts. Importantly, this differential tumor growth during the secondary transplantation was abrogated when recipient mice lacked T cells, indicating that the immune environment in B7-H4 KO hosts allowed outgrowth of 4T1 tumors with reduced immune-evasive capacities against T cells. Thus, B7-H4 can inhibit both antitumor T cells and protumor MDSCs, inﬂuencing the immune-evasive character of the outgrowing tumors. These factors should be considered if B7-H4 blockade is to be used for cancer immunotherapy. The Journal of Immunology , 2013, the of
The diffuse large B-cell lymphoma – where do we stand now in everyday clinical practice

The diffuse large B-cell lymphoma - where do we stand now in everyday clinical practice Background. Due to superior results observed with the addition of rituximab into treatment of patients with the diffuse large B-cell lymphoma (DLBCL), the R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) regimen and its variants became the standard initial treatment of these patients. However, the treatment recommendations are based on results of clinical studies while the conditions of routine treatment are far different from the ones in clinical studies. The aim of this retrospective study was therefore to compare the treatment results of routinely treated patients with the DLBCL to results reported by some larger studies. Patients and methods. Two hundred and ninety five patients with the DLBCL were treated between 2004 and 2008 according to the then protocol with R-CHOP or R-CHOP-like regimens at the Institute of Oncology Ljubljana. Treatment response was evaluated according to Cheson's criteria and the disease-free and overall survival by means of Kaplan Meier survival curves. Results. Response to treatment in our evaluation diverged from the reported one predominately in the low risk group (international prognostic index [IPI] categorisation) and in the very good prognosis group (revised international prognostic index (R-IPI) categorisation). The determined complete response (CR) rates in other IPI and R-IPI groups were generally within expectations. Also in the disease-free survival the largest discrepancy occurred in the low-risk patient group (3 year disease-free survival rate of 75%) and in the very good prognosis group (4 year disease-free survival rate of 59%). In all other IPI risk groups, the disease-free survival at 3 years (low intermediate risk 76%, high intermediate risk group 57%, and high risk group 53%) agreed very well with the quoted ones. Slightly worse was the compliance of the 4 year disease-free survival rates (72% in the good prognosis and 51% in the poor prognosis group) with the results from the literature. The 3 year overall survival rates (low risk patients 87%, high intermediate risk 61% and high risk patients 51%) were somewhat worse than the reported ones in all IPI subgroups except in the low intermediate risk group (82%). On the other hand, the 4 year overall survival rates of the R-IPI categories (94% in the very good prognosis group, 80% in the good prognosis group, 56% in the poor prognosis group) were much better correlated with the data from the literature. Conclusions. In total, the treatment outcomes of routinely treated patient with the DLBCL at our institute are quite encouraging when compared to results of some larger studies. There are probably no dilemmas about how to treat young good prognosis patients and patients aged over 60 years at present. However, the 5 year overall survival rate of 76% for the young poor prognosis group is unsatisfying and needs to be improved. At present, quite a few studies are underway to clarify which of the regimens will perform best in this population.
Pharmacokinetics, Pharmacodynamics, and Tolerability of Single-Dose Oral LCB01-0371, a Novel Oxazolidinone with Broad-Spectrum Activity, in Healthy Volunteers

ABSTRACT LCB01-0371 is a novel oxazolidinone with broad-spectrum activity against Gram-positive pathogens in both in vitro studies and animal infection models. The objectives of this study were to evaluate its safety, tolerability, pharmacokinetics, and pharmacodynamics following single ascending doses. Single oral doses of 600 mg linezolid, a placebo, or LCB01-0371 of between 50 mg and 3,200 mg were tested in 69 healthy male subjects. Blood and urine were sampled, LCB01-0371 concentrations were measured, and the serum inhibitory and bactericidal titers of LCB01-0371 and linezolid were determined. LCB01-0371 was well tolerated up to 2,400 mg. The most common drug-related clinical and laboratory adverse events were nausea with or without vomiting, decreased neutrophil counts, and increased total bilirubin levels. The frequency of adverse events and drug-related adverse events was similar among the treatment groups. The systemic exposure was approximately dose proportional over the range of 50 mg to 800 mg, which includes the anticipated clinical dose. The mean clearance, renal clearance, and volume of distribution were significantly decreased at higher doses (above 800 mg). LCB01-0371 exhibited early bacteriostatic activity against all tested strains except for Streptococcus pneumoniae strains, and the potency of LCB01-0371 at 800 mg was similar to that of linezolid at the therapeutic dose (600 mg). However, LCB01-0371 had less bactericidal activity than linezolid. Taken together, LCB01-0371 was well tolerated, exhibited approximate dose proportionality within the anticipated clinically relevant dose range, and showed bacteriostatic and bactericidal activity comparable to that of linezolid. These results support the further clinical development of LCB01-0371. (This study has been registered at ClinicalTrials.gov under registration no. NCT01554995.)
After VAR: The Theory, Estimation, and Insurance Applications of Quantile-Based Risk Measures

We discuss a number of quantile-based risk measures (QBRMs) that have recently been developed in the financial risk and actuarial/insurance literatures. The measures considered include the Value-at-Risk (VaR), coherent risk measures, spectral risk measures, and distortion risk measures. We discuss and compare the properties of these different measures, and point out that the VaR is seriously flawed. We then discuss how QBRMs can be estimated, and discuss some of the many ways they might be applied to insurance risk problems. These applications are typically very complex, and this complexity means that the most appropriate estimation method will often be some form of stochastic simulation.
Point prevalence of vertigo and dizziness in a sample of 2672 subjects and correlation with headaches

SUMMARY Vertigo and dizziness are common symptoms in the general population, with an estimated prevalence between 20% and 56%. The aim of our work was to assess the point prevalence of these symptoms in a population of 2672 subjects. Patients were asked to answer a questionnaire; in the first part they were asked about demographic data and previous vertigo and or dizziness. Mean age of the sample was 48.3 ± 15 years, and 46.7% were males. A total of 1077 (40.3%) subjects referred vertigo/dizziness during their lifetime, and the mean age of the first vertigo attack was 39.2 ± 15.4 years; in the second part they were asked about the characteristics of vertigo (age of first episode, rotational vertigo, relapsing episodes, positional exacerbation, presence of cochlear symptoms) and lifetime presence of moderate to severe headache and its clinical features (hemicranial, pulsatile, associated with phono and photophobia, worse on effort). An age and sex effect was demonstrated, with symptoms 4.4 times more elevated in females and 1.8 times in people over 50 years. In the total sample of 2672 responders, 13.7% referred a sensation of spinning, 26.3% relapsing episodes, 12.9% positional exacerbation and 4.8% cochlear symptoms; 34.8% referred headache during their lifetime. Subjects suffering from headache presented an increased rate of relapsing episodes, positional exacerbation, cochlear symptoms and a lower age of occurrence of the first vertigo/dizziness episode. In the discussion, our data are compared with those of previous studies, and we underline the relationship between vertigo/dizziness from one side and headache with migrainous features on the other.
A complete axiomatisation of branching bisimulation for process algebras with alternative quantification over data

We define a class of process algebras with silent step and a generalised operation $\gsum{}$ that allows explicit treatment of \emph{alternative quantification} over data, and we investigate the specific subclass formed by the algebras of finite processes modulo rooted branching bisimulation. We give a ground complete axiomatisation for those branching bisimulation algebras of which the data part has built-in equality and Skolem functions.
The Placental Protein Syncytin-1 Impairs Antiviral Responses and Exaggerates Inflammatory Responses to Influenza

Background Pregnancy increases susceptibility to influenza. The placenta releases an immunosuppressive endogenous retroviral protein syncytin-1. We hypothesised that exposure of peripheral monocytes (PBMCs) to syncytin-1 would impair responses to H1N1pdm09 influenza. Methods and Findings Recombinant syncytin-1 was produced. PBMCs from non-pregnant women (n=10) were exposed to H1N1pdm09 in the presence and absence of syncytin-1 and compared to responses of PBMCs from pregnant women (n=12). PBMCs were characterised using flow cytometry, release of interferon (IFN)-α, IFN-λ, IFN-γ, IL-10, IL-2, IL-6 and IL-1β were measured by cytometric bead array or ELISA. Exposure of PBMCs to H1N1pdm09 resulted in the release of IFN-α, (14,787 pg/mL, 95% CI 7311-22,264 pg/mL) IFN-λ (1486 pg/mL, 95% CI 756-2216 pg/mL) and IFN-γ (852 pg/mL, 95% CI 193-1511 pg/mL) after 48 hours. This was significantly impaired in pregnant women (IFN-α; p<0.0001 and IFN-λ; p<0.001). Furthermore, in the presence of syncytin-1, PBMCs demonstrated marked reductions in IFN-α and IFN-λ, while enhanced release of IL-10 as well as IL-6 and IL-1β. Conclusions Our data indicates that a placental derived protein, syncytin-1 may be responsible for the heightened vulnerability of pregnant women to influenza.
Rapid enzymatic measurement of blood lactate and pyruvate. Use and significance of metaphosphoric acid as a common precipitant.

A modification of enzymatic technics for measurement of concentrations of lactate and pyruvate in blood is described. A common protein-free filtrate is prepared by adding blood directly to cold 5% metaphosphoric acid. Theoretical yields are obtained. Recoveries for lactate range from 98 to 102% and for pyruvate from 97 to 104%. Assay of both lactate and pyruvate is simplified and has a high order of reliability. Since both analyses are completed within a period of 20 mm. , the method is especially valuable in the emergent clinical situation in which measurements of lactate and pyruvate are obtained for assessment of the severity of shock and other forms of cardiorespiratory failure.
Cooperation behavior of vehicles in an evolutionary game for information dissemination

In this paper, we study the cooperation behavior of vehicles in a VANET (vehicle ad hoc network) for information dissemination. Any vehicle is only allowed to adopt one of two strategies at the same time: cooperation (forwarding) or defection (dropping), and may change its strategy periodically. We consider the scenario that the incentive for cooperation of any vehicle is controlled according to evolutionary game theory, so that any node only learns its new strategy from its neighbors. Through simulations, we illustrate that, how different parameters, such as node degree, information dissemination amount, information dissemination scheme, channel accessing probability, affect the incentive to be a cooperator for each vehicle in the network.
Histogram of Oriented Gradients with Cell Average Brightness for Human Detection

A modification of the descriptor in a human detector using Histogram of Oriented Gradients (HOG) and Support Vector Machine (SVM) is presented. The proposed modification requires inserting the values of average cell brightness resulting in the increase of the descriptor length from 3780 to 3908 values, but it is easy to compute and instantly gives ≈ 25% improvement of the miss rate at 10‒4 False Positives Per Window (FPPW). The modification has been tested on two versions of HOG-based descriptors: the classic Dalal-Triggs and the modified one, where, instead of spatial Gaussian masks for blocks, an additional central cell has been used. The proposed modification is suitable for hardware implementations of HOG-based detectors, enabling an increase of the detection accuracy or resignation from the use of some hardware-unfriendly operations, such as a spatial Gaussian mask. The results of testing its influence on the brightness changes of test images are also presented. The descriptor may be used in sensor networks equipped with hardware acceleration of image processing to detect humans in the images.
QUANTIFYING QUASAR VARIABILITY AS PART OF A GENERAL APPROACH TO CLASSIFYING CONTINUOUSLY VARYING SOURCES

Robust fast methods to classify variable light curves in large sky surveys are becoming increasingly important. While it is relatively straightforward to identify common periodic stars and particular transient events (supernovae, novae, microlensing events), there is no equivalent for non-periodic continuously varying sources (quasars, aperiodic stellar variability). In this paper, we present a fast method for modeling and classifying such sources. We demonstrate the method using ∼86, 000 variable sources from the OGLE-II survey of the LMC and ∼2700 mid-IR-selected quasar candidates from the OGLE-III survey of the LMC and SMC. We discuss the location of common variability classes in the parameter space of the model. In particular, we show that quasars occupy a distinct region of variability space, providing a simple quantitative approach to the variability selection of quasars.
Using images and explicit binary container for efficient and incremental delivery of declarative 3D scenes on the web

JSON, XML-based 3D formats (e.g. X3D or Collada) and Declarative 3D approaches share some benefits but also one major draw-back: all encoding schemes store the scene-graph and vertex data in the same file structure; unstructured raw mesh data is found within descriptive elements of the scene. Web Browsers therefore have to download all elements (including every single coordinate) before being able to further process the structure of the document. Therefore, we separate the structured scene information and unstructured vertex data to increase the user experience and overall performance of the system by introducing two new referenced containers, which encode external mesh data as so-called Sequential Image Geometry (SIG) or Typed-Array-based Binary Geometry (BG). We also discuss compression, rendering and application results and introduce a novel data layout for image geometry data that supports incremental updates, arbitrary input meshes and GPU decoding.