Miracle-dz/UniFAR-FTUs huggingface dataset:
Traditional Custodianship: a useful framework for heritage management in southern Africa?

Formal heritage management systems have failed to protect archaeological sites in many parts of southern Africa. Since historical times, local communities living in close proximity to heritage places have often played a large role in ensuring the survival of places of cultural significance through their traditional custodianship systems. Yet often these systems are ignored or not fully recognized by the State heritage management organizations. This study investigates whether an intimate understanding of traditional custodianship systems can provide direction towards a more effective and sustainable method of managing archaeological sites imbued with sacred values. In an attempt to harness the positive parts of both the traditional and formal systems, the work recommends the adoption of a framework enriched by a philosophy of rooted cosmopolitanism that embraces legal pluralism in heritage legislation and cultural polices.
On the Choice Between Graph-Based and Block-Structured Business Process Modeling Languages

The most prominent business process notations in use today are BPMN, EPC and BPEL. While all those languages show similarities on the conceptual level and share similar constructs, the semantics of these constructs and even the intended use of the language itself are often quite different. As a result, users are uncertain when to use which language or construct in a particular language, especially when they have used another business process notation before. In this paper, we discuss the core characteristics of graph-based and block-structured modeling languages and compare them with respect to their join and loop semantics.
Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection

In Drosophila, post-transcriptional gene silencing occurs when exogenous or endogenous double stranded RNA (dsRNA) is processed into small interfering RNAs (siRNAs) by Dicer-2 (Dcr-2) in association with a dsRNA-binding protein (dsRBP) cofactor called Loquacious (Loqs-PD). siRNAs are then loaded onto Argonaute-2 (Ago2) by the action of Dcr-2 with another dsRBP cofactor called R2D2. Loaded Ago2 executes the destruction of target RNAs that have sequence complementarity to siRNAs. Although Dcr-2, R2D2, and Ago2 are essential for innate antiviral defense, the mechanism of virus-derived siRNA (vsiRNA) biogenesis and viral target inhibition remains unclear. Here, we characterize the response mechanism mediated by siRNAs against two different RNA viruses that infect Drosophila. In both cases, we show that vsiRNAs are generated by Dcr-2 processing of dsRNA formed during viral genome replication and, to a lesser extent, viral transcription. These vsiRNAs seem to preferentially target viral polyadenylated RNA to inhibit viral replication. Loqs-PD is completely dispensable for silencing of the viruses, in contrast to its role in silencing endogenous targets. Biogenesis of vsiRNAs is independent of both Loqs-PD and R2D2. R2D2, however, is required for sorting and loading of vsiRNAs onto Ago2 and inhibition of viral RNA expression. Direct injection of viral RNA into Drosophila results in replication that is also independent of Loqs-PD. This suggests that triggering of the antiviral pathway is not related to viral mode of entry but recognition of intrinsic features of virus RNA. Our results indicate the existence of a vsiRNA pathway that is separate from the endogenous siRNA pathway and is specifically triggered by virus RNA. We speculate that this unique framework might be necessary for a prompt and efficient antiviral response.
A SPICE Compact Model for Unipolar RRAM Reset Process Analysis

A physically based circuit model is proposed for SPICE simulation of thermally assisted reset transitions in resistive switching devices. The model allows the simulation of conductive filaments with complex structures, such as a main filament with several subfilaments attached forming a tree structure, or several filaments interlaced between them. The model has been validated by comparing with experimental data and the simulations obtained with a previously published simulation tool. A study of the influence of different subfilaments configurations on the variability of resistive random access memory I-V reset curves is also presented.
GUIDING CONCEPTIONS AND ASSESSMENT PRINCIPLES FOR THE PRAXIS SERIES: PROFESSIONAL ASSESSMENTS FOR BEGINNING TEACHERS™

This paper discusses underlying beliefs about teaching that are related to the assessment of prospective teachers and elucidates some basic beliefs that are guiding the development of new types of assessments for new teachers. These new assessments are called "The Praxis Series: Professional Assessments for Beginning Teachers(TM). " Differences among learners are of critical importance in the teaching-learning process. In addition to the different requirements of different students, there are different requirements for teaching different subjects. Teachers need to develop an instructional repertoire and skill in selecting appropriate procedures from this repertoire. In constructing the Praxis Assessments, teaching tasks have been grouped into four broad domains for discussion, analysis, and assessment: (1) organizing content knowledge for student learning; (2) creating an environment for student learning; (3) teaching for student learning; and (4) teacher professionalism. Each task domain must be examined from thought and action perspectives. This view of teaching and learning has implications for any assessment construction and implementation, but especially for the performance-based assessments that will be a component of The Praxis Series. An appendix lists 12 learner-centered psychological principles. Two figures illustrate the domains. (SLD) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. uxumuuumuuwwwwmuul.uuuuuxuumuuuxxxuxuuu*uxxxxx************************ LU mpD Vi MAI SERIES Professional Assessments for Beginning Teachers' U.S DEPARTMENT OF EDUCATION CPIK e N Eclucahonat Research and Improvement ECU ATIONAL RE SOURCES INFORMATION CENTER (ERIC) 'Ns document has been reproduced as received from the PerSOn or organization Originating (I Ir` Minor changes have been made lo improve repoduct.on auakty Points of view or opinions slated gnthEsdOCu ment do not neCeSsanry represent official OE RI posibon or policy -PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY ,e,e,9uiv TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC). RR-93-17 GUIDING CONCEPTIONS AND ASSESSMENT PRINCIPLES for The Praxis Series: Professional Assessments for Beginning Teachers. ' Carol Anne Cwyer and Ana Maria Villegas Revised January 1993
Assessing the Accuracy of Decisions

Much research demonstrates that people's choices do not conform to utility theory, a model of rational decision-making (Baron, 1988; Kahneman & Tversky, 1979; Slovic, Lichtenstein, & Fischhoff, 1988). Researchers have begun to question the normative status of utility theory in light of the many empirical violations of the theory. We argue that consistency with a formal model is not an appropriate standard for evaluating the quality of decisions. Rather, we propose that accuracy is a more useful standard. We define an accurate decision as one in which there is a one-to-one correspondence between the factors that affect a decision and those that affect experience. Based on our definition, we address the question of whether violations of normative models such as expected value theory and expected utility theory reflect inaccurate decisions. We argue that some violations of normative models do lead to inaccurate decisions. However, many violations may arise because the normative models prohibit factors from affecting decisions that do in fact affect the experience of the outcomes of decisions.
Behavioral and psychological consequences of unemployment in blue‐collar couples

The behavioral and psychological consequences of involuntary unemployment in blue-collar couples were investigated using Scanzoni's (1972) dynamic model of marital exchange. Thirty-one couples in which the husband had been laid off for at least 3 months were compared with 32 couples in which the husband was employed full time, in terms of exchange behaviors, psychological well-being, and marital satisfaction. As predicted, unemployed husbands reported lower psychological well-being and marital satisfaction, while their wives reported lower marital satisfaction. Unemployed husbands had not significantly altered their exchange behaviors, perhaps due in part to their traditional attitudes toward marital roles which continue to render the contemporary marital exchange relatively inflexible. Level of expressive behavior was by far the most powerful predictor of marital satisfaction for husbands and wives alike. Incongruity in attitudes toward marital roles between traditional husbands and modern wives may constitute both a preexisting source of dissatisfaction and a risk factor following unemployment. These results partially support Scanzoni's model but suggest that the negative consequences of unemployment in blue-collar couples appear first in the psychological as opposed to the behavioral domain.
Acute Otitis due to Vibrio fluvialis after Swimming

A 40-year-old female presented with purulent exudate through the left auditive duct and pain in the left ear region, which intensified during mastication. After collection of the pus from the left ear lesion, amoxicillin-clavulanic acid for seven days was prescribed for a presumed diagnosis of acute otitis. Four days later, the pus culture grew V. fluvialis which is further identified by API 20E identification system (bioMérieux). Following the successful completion of a course of antibiotics, the patient recovered completely and without complication. To the best of our knowledge, this is the first case of Vibrio fluvialis otitis after swimming in an immunocompetent patient.
Radiological and clinical findings of 25 patients with invasive pulmonary aspergillosis: retrospective analysis of 2150 liver transplantation cases.

OBJECTIVE The purpose of this study was to evaluate the radiological and clinical findings of invasive pulmonary aspergillosis (IPA) after liver transplantation. METHODS This study included 25 consecutive liver transplant recipients with histologically confirmed IPA after liver transplantation. Radiological examinations performed for diagnosis were available in all patients. Clinical findings and changes in clinical response and radiological findings after treatment were also evaluated. RESULTS 3 main radiological findings were identified: nodules, 64% (16/25); masses, 36% (9/25); and consolidations in a patchy pattern, 20% (5/25). A tree-in-bud pattern was found in 12% (3/25) of patients. In 8 (32%) of 25 patients, we found a combination of 2 or more of these signs: 5 (20%) patients presented with concurrent nodules accompanied by patchy consolidations and/or tree-in-bud, and 3 (12%) patients showed masses accompanied by large consolidations. A halo sign was observed in 20 (80%) of 25 patients. Hypodense sign and cavitary lesions were encountered in 17 (68%) of 25 patients. Follow-up radiological findings after treatment showed improvement in 18 patients, no change in 4 patients and progression in 3 patients. There were three aspergillosis-associated deaths during the follow-up period. The onset time of IPA was a median of 31 days after transplantation. The most common symptom at diagnosis was fever (n=15). None of the 25 patients had leukopaenia at the time of the diagnosis of IPA. CONCLUSIONS The most common radiological findings of IPA after liver transplantation are multiple nodules with or without halo sign, masses and consolidations, which usually appear about 1 month after transplantation.
Focal adhesion kinase is redistributed to focal complexes and mediates cell spreading in macrophages in response to M-CSF

Abstract The macrophage colony-stimulating factor (M-CSF, CSF-1) regulates survival, proliferation and differentiation of mononuclear phagocytes, as well as macrophage motility and morphology. The latter features are usually regulated by ECM-mediated activation of integrins and subsequent tyrosine phosphorylation of cellular proteins, including focal adhesion kinase (FAK). FAK is phosphorylated by downstream receptor tyrosine kinases as well. We addressed the question whether M-CSF regulates FAK tyrosine phosphorylation in macrophages, and found that M-CSF induces FAK phosphorylation at all known tyrosine residues. This phosphorylation was dependent on Src. Extracellularly-regulated kinase (ERK), Jun N-terminal kinase (JNK) and phosphatidylinositol-3-kinase (PI3K) were found to be negatively involved in M-CSF-induced FAK phosphorylation, as their inhibition resulted in FAK hyper-phosphorylation. Following M-CSF treatment, FAK and the active forms of M-CSFR and Src were redistributed to the cytoskeleton, where active ERK, JNK and PI3K were detectable. Immunofluorescence showed the presence of FAK and its active form in focal complexes following M-CSF treatment. Moreover, cell spreading and adhesion were impaired when FAK tyrosine phosphorylation was abrogated by either transfection with FRNK, a dominant negative form of FAK, or treatment with a number of inhibitors of upstream FAK-activating signals. These results point to a relevant role for FAK in the regulation of cell spreading and adhesion in macrophages.
Wit, power, and oppositional groups: A case study of “pure talk”

This article describes Pure Talk, a type of witty conversation practiced in China from 200–600 C.E. Pure Talk differs from other uses of wit by oppositional, marginalized groups because its practitioners came from the elite and were not inherently stigmatized. Pure Talk is compared to two contemporary uses of wit by oppositional marginalized groups, African‐Americans and gay men. This comparison is used to support some hypotheses about the advantages and drawbacks of the game of wit and to raise some questions about the values assumed by this communicative strategy, its effects on its practitioners, and the degree to which such wit is truly oppositional.
Mutations at Beta N265 in γ-Aminobutyric Acid Type A Receptors Alter Both Binding Affinity and Efficacy of Potent Anesthetics

Etomidate and propofol are potent general anesthetics that act via GABAA receptor allosteric co-agonist sites located at transmembrane β+/α− inter-subunit interfaces. Early experiments in heteromeric receptors identified βN265 (M2-15′) on β2 and β3 subunits as an important determinant of sensitivity to these drugs. Mechanistic analyses suggest that substitution with serine, the β1 residue at this position, primarily reduces etomidate efficacy, while mutation to methionine eliminates etomidate sensitivity and might prevent drug binding. However, the βN265 residue has not been photolabeled with analogs of either etomidate or propofol. Furthermore, substituted cysteine modification studies find no propofol protection at this locus, while etomidate protection has not been tested. Thus, evidence of contact between βN265 and potent anesthetics is lacking and it remains uncertain how mutations alter drug sensitivity. In the current study, we first applied heterologous α1β2N265Cγ2L receptor expression in Xenopus oocytes, thiol-specific aqueous probe modification, and voltage-clamp electrophysiology to test whether etomidate inhibits probe reactions at the β-265 sidechain. Using up to 300 µM etomidate, we found both an absence of etomidate effects on α1β2N265Cγ2L receptor activity and no inhibition of thiol modification. To gain further insight into anesthetic insensitive βN265M mutants, we applied indirect structure-function strategies, exploiting second mutations in α1β2/3γ2L GABAA receptors. Using α1M236C as a modifiable and anesthetic-protectable site occupancy reporter in β+/α− interfaces, we found that βN265M reduced apparent anesthetic affinity for receptors in both resting and GABA-activated states. βN265M also impaired the transduction of gating effects associated with α1M236W, a mutation that mimics β+/α− anesthetic site occupancy. Our results show that βN265M mutations dramatically reduce the efficacy/transduction of anesthetics bound in β+/α− sites, and also significantly reduce anesthetic affinity for resting state receptors. These findings are consistent with a role for βN265 in anesthetic binding within the β+/α− transmembrane sites.
Portfolios for learning, assessment and professional development in higher education

This article focuses on the use of portfolios for learning and professional development in Higher Education (HE). Recent research findings related to learning and assessment help to contextualize the study. The use of portfolios for summative assessment and development of teaching and reflective practice dominates the literature. What is lacking is research that provides insights into how a portfolio for learning can be used in HE to develop understanding into one’s own learning, assessment and professional practices. The action research findings related to portfolio use for learning purposes identified in the three case studies include: the importance of establishing the purpose of the portfolio; the impact of portfolio use on the approach to learning, to teaching and to professional development; the changes to professional practice brought about as a result of the learning; and the need to consider issues related to ethics and confidentiality.
Fuzzy min-max neural network based decision trees

This paper presents a new decision tree learning algorithm, fuzzy min-max decision tree (FMMDT) based on fuzzy min-max neural networks. In contrast with traditional decision trees in which a single attribute is selected as the splitting test, the internal nodes of the proposed algorithm contain a fuzzy min-max neural network. In the proposed learning algorithm, the flexibility inherent in the fuzzy logic and the computational efficiency of the min-max neural networks are combined in the decision tree learning framework. FMMDT splits the feature space non-linearly based on multiple attributes which provides not only conceptually more insightful splits but also decision trees with smaller size and depth. The decision trees resulted from the FMMDT learning algorithm have a non-traditional architecture, which enables determining the class label of the instances as early as possible. Moreover, FMMDT creates decision trees which are interpretable by the domain expert. It is shown experimentally that the decision trees resulted from the proposed FMMDT learning algorithm achieve the highest accuracy and the lowest size and depth in comparison with C4.5, BFTree, SimpleCart and NBTree on the most commonly used UCI data sets. Moreover, the experiments reveal that FMMDT creates decision trees with stable structure.
Up‐regulation of neutral endopeptidase (CALLA) in human neutrophils by granulocyte‐macrophage colony‐stimulating factor

Neutral endopeptidase 24.11 (NEP/CALLA/ CD10), an enzyme expressed on early lymphoid progenitors, neutrophils, and various other cell types, inactivates many biologically active peptides, including the bacterial chemo‐ tactic peptide M‐formylmethionyl‐leucyl‐phenylalanine (fMLP). Inhibition of CD10/NEP on the surface of human neutrophils (PMNs) in vitro inhibits migration toward this chemotaxin, suggesting that enzymatic inactivation by NEP regulates the neutrophil response to fMLP. Because PMNs in inflammatory sites are exposed to various cytokines, we evaluated the effects of selected cytokines on CD10/NEP activity in vitro. Of five cytokines tested—interleukin‐1 (IL‐1), IL‐6, and IL‐8, granulocyte colony‐stimulating factor, and granulocyte‐ macrophage colony‐stimulating factor (GM‐CSF) —GM‐ CSF provided the most consistent increase in surface NEP activity. Low concentrations (10−9‐10−7 M) of GM‐ CSF increased NEP activity in a time‐ and concentration‐ dependent manner to more than 225% that of control (phosphate‐buffered saline‐treated) cells. Cytofluorome‐ try of cells stained with a fluorescent antibody to CD10 indicated that GM‐CSF increased expression of surface CD10/NEP antigen in a similar manner. The effect of GM‐CSF on NEP activity was enhanced still further by simultaneous exposure to IL‐1, suggesting that combinations of cytokines may direct and regulate the neutrophil response within an inflammatory site. Rapid up‐ regulation of CD10/NEP underscores the importance of this enzyme for control of peptide mediators of inflammation.
Structural transition in the metal-free hexamer of protein-engineered [B13 Gln]insulin.

For hexamer formation of native insulin the repulsive potential of six B13 Glu carboxylate groups coming together in the centre is overcome by zinc binding to B10 His. Substitution of Gln for Glu in position B13 by site-directed mutagenesis, i.e. replacement of the repelling carboxylates by amide groups, which are offering H-bonding potential, enhances association and allows a metal-free hexamer to form. Merely upon addition of zinc ions this hexamer undergoes the T6----T3R3 respectively T6----R6 structural transition which in the native 2Zn insulin hexamer is inducible only by additives like inorganic anions or phenolic compounds. [B13 Gln]Insulin hexamers are transformed by phenolic compounds, but not by anions, even in the absence of any metal. The structural transformation of insulin can thus be brought about in two ways: By inorganic ions with the zinc ions as their points of attack, which preexist in the nontransformed hexamer, and by phenol, for which the binding sites close to the B5 histidines come into existence only with the transformation. Therefore transformed and non-transformed hexamers, i.e. molecules with helical and extended B chain N-terminus, must be related in a dynamic equilibrium. Phenol acts as a wedge jamming the structure in the transformed state and trapping the zinc ions. Combination of transformed 2Zn[B13 Gln]insulin and metal-free native insulin in the absence of additives results in a redistribution of the zinc ions in favour of native insulin which is an outcome of the dynamic equilibrium and also demonstrates an influence of B13 charge on metal binding affinity. Transformation of a single subunit in a hexamer would lead to bad contacts. (ABSTRACT TRUNCATED AT 250 WORDS)
The Military Doctrine of the Russian Federation

: This paper investigates Russian Military Doctrines which establish the military construction and training of state armed forces and set out the forms and methods of conducting war. The main provisions of Military/Defense Doctrines have been formed and changed depending on current policy and the existent social system. This includes the level of productive forces and new scientific achievements and the nature of anticipated war. The 2014 Russian Military Doctrine defines the country as a strictly defensive entity and issues a list of provisions where Russia would be motivated to act militarily towards other countries. State policy and military doctrine are inextricably linked because the competent military policy meets all changes in international and domestic situations and successive military reforms are impossible without corresponding reflection in Military Doctrine.