Miracle-dz/UniFAR-FTUs huggingface dataset:
Apical ridge dependent and independent mesodermal domains of GHox-7 and GHox-8 expression in chick limb buds.

The homeobox-containing genes GHox-7 and GHox-8 have been proposed to play fundamental roles in limb development. The expression of GHox-8, by the apical ridge cells, and GHox-7, in the subridge mesoderm, suggests the involvement of these two genes in limb outgrowth and proximo-distal pattern formation. A straightforward way to test this is to remove the apical ridge. Here we report the relationship between the mesodermal expression of GHox-7 and GHox-8 and the apical ectodermal ridge in the chick limb bud. The data from ridge removal experiments indicate that there are at least two domains of GHox-7 expression in the apical limb bud mesoderm. The posterior subridge GHox-7 domain in the progress zone requires the influence of the apical ridge for continued expression, while the anterior GHox-7 domain continues expression after ridge removal. Posterior subridge mesoderm is exquisitely sensitive to the loss of the ridge in that GHox-7 expression by these cells is reduced in only two hours and undetectable by three hours after ridge removal. It would appear that one of the ways progress zone cells respond to the apical ridge signal is by expressing GHox-7. The loss of ridge influence whether by growth at the apex or by ridge removal is followed by an unusually rapid decline in detectable GHox-7 transcripts. Maintenance of GHox-8 expression by the anterior mesoderm appears to be independent of the presence of the apical ridge. (ABSTRACT TRUNCATED AT 250 WORDS)
Evaluation of the Children’s Depression Inventory—Short Version (CDI–S)

The Children’s Depression Inventory—Short Version (CDI–S), an abbreviated version of the widely used Children’s Depression Inventory (CDI), has been regularly used in recent research. In comparison to the original CDI, the CDI–S has not been rigorously evaluated for its psychometrics. The present study examined the dimensionality, convergent and discriminant validity, and gender differences of the CDI–S in a school-based sample of 809 children 8–12 years of age. All children completed the CDI–S. One subsample additionally completed another measure of depression, 1 subsample completed a measure of anxiety, and 1 subsample completed the CDI–S at a second occasion, after 2 weeks. Information regarding parents’ education and household income were available for 476 children. We evaluated the dimensionality of the CDI–S in a series of exploratory factor analyses. Despite some evidence of multidimensionality, a bifactor model revealed that the variation of scores was primarily explained by variations of the general factor. Consequently, the CDI–S is most adequately interpreted as a univocal measure. The CDI–S showed high correlation to another measure of depression and a moderately high correlation to a measure of anxiety, with nonoverlapping confidence intervals. We also found that girls reported higher levels of depressive symptoms than did boys, and we found a negative correlation between depressive symptoms and socioeconomic factors for boys only. Future studies should preferably include a broader age range, to acquire a more comprehensive understanding of the validity of the CDI–S.
Sebacina vermifera Promotes the Growth and Fitness of Nicotiana attenuata by Inhibiting Ethylene Signaling1[W]

Sebacina vermifera, a growth-promoting endophytic fungus, significantly increases Nicotiana attenuata's growth but impairs both its herbivore resistance and its accumulation of the costly, jasmonic acid (JA)-regulated defense protein, trypsin proteinase inhibitor (TPI). To determine if the fungi's growth-promoting effects can be attributed to lower TPI-related defense costs, we inoculated transformed N. attenuata plants silenced in their ability to synthesize JA, JA-isoleucine, and TPI by antisense (lipoxygenase 3 [as-lox3] and Thr deaminase [as-td]) and inverted repeat (ir-tpi) expression, and found that inoculation promoted plant growth as in untransformed wild-type plants. Moreover, herbivore-elicited increases in JA and JA-isoleucine concentrations did not differ between inoculated and uninoculated wild-type plants. However, inoculation significantly reduced the morphological effect of 1-aminocyclopropane-1-carboxylic acid on wild-type seedlings in a triple response assay, suggesting that ethylene signaling was impaired. Furthermore, S. vermifera failed to promote the growth of N. attenuata plants transformed to silence ethylene production (1-aminocyclopropane-1-carboxylic acid oxidase [ir-aco]). Inoculating wild-type plants with S. vermifera decreased the ethylene burst elicited by applying Manduca sexta oral secretions to mechanical wounds. Accordingly, oral secretion-elicited transcript levels of the ethylene synthesis genes NaACS3, NaACO1, and NaACO3 in inoculated plants were significantly lower compared to these levels in uninoculated wild-type plants. Inoculation accelerated germination in wild-type seeds; however, uninoculated wild-type seeds germinated as rapidly as inoculated seeds in the presence of the ethylene scrubber KMnO4. In contrast, neither inoculation nor KMnO4 exposure influenced the germination of ir-aco seeds. We conclude that S. vermifera increases plant growth by impairing ethylene production independently of JA signaling and TPI production.
Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile

Aclidinium bromide is a novel potent, long-acting inhaled muscarinic antagonist in development for the treatment of chronic obstructive pulmonary disease. Aclidinium showed subnanomolar affinity for the five human muscarinic receptors (M1–M5). [3H]Aclidinium dissociated slightly faster from M2 and M3 receptors than [3H]tiotropium but much more slowly than [3H]ipratropium. Its association rate for the M3 receptor was similar to [3H]ipratropium and 2.6 times faster than [3H]tiotropium. Residence half-life of [3H]aclidinium at the M2 receptor was shorter than at the M3 receptor, demonstrating kinetic selectivity for the M3 receptor. In isolated guinea pig trachea, aclidinium showed comparable potency to ipratropium and tiotropium, faster onset of action than tiotropium, and duration of action similar to tiotropium and significantly longer than ipratropium. Nebulized aclidinium inhibited bronchoconstriction induced by acetylcholine in guinea pigs in a concentration-dependent manner with an onset of action faster than tiotropium. Duration of action of aclidinium (t1/2 = 29 h) was much longer than ipratropium (8 h) but shorter than tiotropium (64 h). In dogs, aclidinium induced a smaller and more transient increase in heart rate than tiotropium at comparable supratherapeutic doses. Therefore, under these conditions, aclidinium showed a greater therapeutic index than tiotropium (4.2 versus 1.6). These results indicate that aclidinium is a potent muscarinic antagonist with a fast onset of action, a long duration of effect, and a favorable cardiovascular safety profile.
“RE-VALUING” READING: ASSESSING ATTITUDE AND PROVIDING APPROPRIATE READING SUPPORT

The authors contend that the students, even those labeled “at risk” or “struggling,” learn to read by reading—having time, opportunity, and support for active construction of meaning from text and reading books that are exciting, age-appropriate, enjoyable, and often self-chosen. Using examples from classrooms, the authors argue that assessing what children know about reading, their interests, and their successful reading/writing strategies will help counteract a dismal cycle that traps those who fail to perform proficiently on worksheets, flash cards, and other drills. If teachers create a literate environment supporting all readers in their efforts to make sense of literacy events, students will come to revalue reading, the process of meaningful interaction with print. The authors believe reading is a matter of “catching on” to an authentic experience of literacy and the power that participation gives.
Sexual exclusivity among dating, cohabiting, and married women

Data drawn from the 1991 US National Survey of Women revealed significant differences between married women and cohabiting or dating women in their level of commitment to a partner. Sexual exclusivity was selected as the proxy for commitment and compared in 1235 dating cohabiting and married women 20-37 years old. 4% of married women 18% of dating women and 20% of cohabiting women reported a secondary sex partner. In the latter group each month of cohabitation increased the odds of a secondary sexual relationship by 2%. Characteristics of married women that significantly increased the odds of a secondary relationship included no religious affiliation 4 or more previous sexual partners husband more than 2 years older and higher educational level on the part of the female versus the male partner. Among dating and cohabiting women the significantly predictive factors of a secondary sexual relationship included college education no religious affiliation religious heterogamy with partner higher educational attainment on the part of the woman versus her partner minority race or ethnicity and having had previous sex partners. Both before and after marriage the risk of having a secondary sex partner was increased (1.7 and 3.3 times respectively) among married women who had cohabited prior to marriage compared to those who had not. These findings support previous research suggesting that cohabitation is selective of women less committed to a relationship. Finally the research revealed that cohabiting women are more likely when they marry than women with no history of cohabitation to select partners similar to themselves in terms of educational level--another indication that women in this category value independence and equality in a relationship.
Culture and Pedagogy: International Comparisons in Primary Education

Robin Alexander’s Culture and Pedagogy received the American Educational Research Association’s ‘‘Outstanding Book of the Year Award’’ this past year. This distinguished volume deserved the award. First, Culture and Pedagogy is distinguished by its ambition: to reconstruct the context and practice of primary education (for children between approximately 5 and 10) in five nations: England, France, India, Russia, and the United States. Professor Alexander spent well over a decade deeply engaged in carefully selected cases reasonably expected to capture essential qualities of mass public education in those nations with radically different traditions of schooling. His efforts to understand and contrast the traditions, values, investments, machinery of control, and organizational forms – based on extensive interviews with communities of policy-makers, citizens, and professional educators – coupled with an acute reading of relevant national historical, policy, and local systemlevel documents, are represented in the first two parts of his book: Settings and Schools. These rich and focused sections alone could have been released as a smart volume in the comparative history and sociology of education.
Response to erlotinib in a patient with lung adenocarcinoma harbouring the EML4-ALK translocation: A case report

Lung cancer is the leading cause of cancer-associated mortality worldwide, and the mainstay of treatment remains to be personalised therapy. Tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKIs) have been reported to exert a significant impact in the treatment of non-small cell lung cancer (NSCLC), particularly in patients harbouring mutations in the EGFR gene. The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) gene translocation has been described in a subset of patients with NSCLC and possesses potent oncogenic activity. This translocation represents one of the most novel molecular targets in the treatment of NSCLC. Patients who harbour the EML4-ALK rearrangement possess lung tumours that lack EGFR or K-ras mutations. The present study reports the case of a patient possessing the EML4-ALK rearrangement that was initially treated with erlotinib and achieved a lasting clinical response. To the best of our knowledge, the current study is the first report of a clinical response to EGFR-TKI in a patient with lung adenocarcinoma harbouring the EML4-ALK fusion gene, but no EGFR mutations. However, as the disease progressed, the ALK gene status of the tumour was investigated, and based upon a positive result, the patient was treated with crizotinib and achieved a complete response. In conclusion, the present study suggests that the EML4-ALK rearrangement is not always associated with resistance to EGFR-TKIs. Further studies are required to clarify the biological features of these tumours and to investigate the mechanisms underlying the primary resistance to EGFR-TKIs when the EML4-ALK rearrangement is present.
Talking the Talk or Walking the Walk? The Leadership of Planned and Emergent Change in a Public Organization

Abstract The implementation of public management reform may entail radical change for public sector organizations, as it implies changes in the values of the organization. Although such organizational changes are widespread and prevalent in the public sector, the processes through which such changes take place are largely overlooked in the public management literature. By means of an embedded, comparative case study, the authors analyse both planned and emergent processes of change. Their analysis indicates that changes come about through careful reinterpretation and reframing of organizational commitments, rather than replacement of the old by the new values. Moreover, there are important differences in the leadership activities in planned and emergent processes of organizational change. They highlight the need for an increased understanding of the role of leadership in emergent processes of change. In order to successfully change public organizations, they find that the approach to change and corresponding leadership activities should be congruent with the content of the desired organizational change. Managers must dare to go beyond talking the talk and start walking the walk.
Spectrum of the Supernova Relic Neutrino Background and Evolution of Galaxies

The spectrum of the supernova relic neutrino background (SRN) from collapse-driven supernovae ever occurred in the universe is calculated by using a realistic, time-dependent supernova rate derived from a standard model of galaxy evolution based on the population synthesis method. The SRN spectrum we show here is the most realistic at present, because the largest uncertainty in previous theoretical predictions has come from unrealistic assumptions of the supernova rate so far made. The SRN is one of the targets of the Superkamiokande (SK) detector which will be constructed in a year and the SRN, if at all detected, would provide a new tool to probe the history of supernova explosions in the universe. The expected event rate at the SK is therefore calculated in this paper. Our major results include: (1) the supernova rate is much higher in the early phase of evolution of galaxies and there appears a hump in the SRN spectrum in the low-energy region of $\ltilde 5$ MeV, (2) the SRN flux depends on the Hubble constant ($H_0$) in a way approximately proportional to $H_0^2$ and only weakly on the density parameter of the universe ($\Omega_0$) and a cosmological constant ($\lambda_0$), and (3) the plausible event rate at the SK is 1.2 yr$^{-1}$ in the observable energy range. Such a low event rate is due mainly to a quite low supernova rate at present which is averaged over the morphological types of galaxies. The most optimistic rate in our model is found to be 4.7 yr$^{-1}$, and if more events are detected, we will have to reconsider our current understanding of collapse-driven supernovae and evolution of galaxies.
Coherent Radar Target Detection in Heavy-Tailed Compound-Gaussian Clutter

This paper deals with the problem of detecting a radar target signal against correlated non-Gaussian clutter, which is modeled by the compound-Gaussian distribution. We prove that if the texture of compound-Gaussian clutter is modeled by an inverse-gamma distribution, the optimum detector is the optimum Gaussian matched filter detector compared to a data-dependent threshold that varies linearly with a quadratic statistic of the data. We call this optimum detector a linear-threshold detector (LTD). Then, we show that the compound-Gaussian model presented here varies parametrically from the Gaussian clutter model to a clutter model whose tails are evidently heavier than any K-distribution model. Moreover, we show that the generalized likelihood ratio test (GLRT), which is a popular suboptimum detector because of its constant false-alarm rate (CFAR) property, is an optimum detector for our clutter model in the limit as the tails get extremely heavy. The GLRT-LTD is tested against simulated high-resolution sea clutter data to investigate the dependence of its performance on the various clutter parameters.
A 5-year retrospective of post-separation shared care research in Australia

Abstract In recent years, sweeping changes to the Australian family law system – new services, legal processes, legislation, and a new child support scheme – have been put into place, accompanied by a large research evaluation program. A central plank running through the recent reforms is the need for courts, and those who work with separating parents, to consider whether a child spending equal or else substantial and significant periods of time with each parent would be in his or her best interest and be reasonably practicable. While legal professionals, practitioners and policy analysts wait for the first wave of findings about how the new system is working, now seems like an opportune moment to pause and reflect on the past 5 years of Australian research into shared care. Do we know much more than we did 5 years ago when equal parenting time was first given formal policy prominence? The short answer is ‘Yes’ but the long answer is that our knowledge still remains at a basic level.
‘We were expected to be equal’: teachers and academics sharing professional learning through practitioner inquiry

This paper describes a process in which early childhood professionals, who were novice researchers, engaged in their own research projects in collaboration with academics through a practitioner inquiry group. The aim of the project was to introduce the concepts and practices of practitioner enquiry, and learn about, plan and implement a self-initiated change project in consultation with academics. The paper details how a group of teachers succeeded in sustaining a community of practice that promoted teacher professionalism and change. Research has previously called for a shift in professional habitus and raised concerns about the value of teacher learning groups, the dispositions of teachers to call on academic research, and by implication, the desire to work actively with academics. Here we draw upon empirical data to raise the hope that the enablement and dissemination of collaborative change-focused research projects, while challenging, may provide viable avenues for successful teacher change.
Contributions of Family Relationship Factors to the Identity Formation Process

This study tested the proposition that family relationship variables would be related in predictable ways to ego identity status. The authors administered measures of parental attachment, psychological separation, and ego identity status to 174 students from a large northeastern state university. The results indicated that women who experience greater parental attitudinal dependence and attachment and a modest degree of conflictual independence from mother tend to evidence more identity foreclosure and identity achievement and less diffusion. In addition, women who experience some degree of attachment to mother and attitudinal independence from mother are most likely to avoid diffusion, foreclosure, and moratorium. Men who experience parental attitudinal independence are likely to be in the diffusion or moratorium statuses and not in the identity-achieved and foreclosure statuses.
Lactoferrin Inhibits the Lipopolysaccharide-Induced Expression and Proteoglycan-Binding Ability of Interleukin-8 in Human Endothelial Cells

ABSTRACT Interleukin-8 (IL-8), a C-X-C chemokine bound to endothelium proteoglycans, initiates the activation and selective recruitment of leukocytes at inflammatory foci. We demonstrate that human lactoferrin, an antimicrobial lipopolysaccharide (LPS)-binding protein, decreases both IL-8 mRNA and protein expression induced by the complex Escherichia coli 055:B5 LPS/sCD14 in human umbilical vein endothelial cells. The use of recombinant lactoferrins mutated in the LPS-binding sites indicates that this inhibitory effect is mediated by an interaction of lactoferrin with LPS and CD14s that suppresses the endotoxin biological activity. Furthermore, since dimeric IL-8 and lactoferrin are both proteoglycan-binding molecules, the competition between these proteins for heparin binding was investigated. Lactoferrin strongly inhibited the interaction of radiolabeled IL-8 to immobilized heparin, whereas a lactoferrin variant lacking the amino acid residues essential for heparin binding was not inhibitory. Moreover, this process is specific, since serum transferrin, a glycoprotein whose structure is close to that of lactoferrin, did not prevent the interaction of IL-8 with heparin. These results suggest that the anti-inflammatory properties of lactoferrin during septicemia are related, at least in part, to the regulation of IL-8 production and also to the ability of lactoferrin to compete with chemokines for their binding to proteoglycans.
The interplay between counterfactual reasoning and feedback dynamics in producing inferences about the self

Counterfactual reasoning research typically demonstrates contrast effects—nearly winning evokes frustration, whereas nearly losing evokes exhilaration. The present work, however, describes conditions under which assimilative responses (i.e., when judgements are pulled towards a comparison standard) also occur. Participants solved analogies and learned that they had either nearly attained a target score or nearly failed to attain it. Participants in the no trajectory condition received this feedback in the absence of any prior feedback, whereas those in the trajectory condition received feedback after having received prior feedback conforming to either an ascending or descending pattern. Participants then provided perceptions of their verbal intelligence. Assimilation effects were observed in the trajectory conditions but attenuated in the no trajectory conditions. Discussion focuses on the role of feedback dynamics in determining responses to close-call counterfactuals.