Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Precision Vehicle Navigation in Urban Environments Using an MEM's IMU and Single-Frequency GPS Receiver

Many applications demand high-precision navigation in urban environments. Two frequency real-time kinematic (RTK) Global Positioning System (GPS) receivers are too expensive for low-cost or consumer-grade projects. As single-frequency GPS receivers are getting less expensive and more capable, more people are utilizing single-frequency RTK GPS techniques to achieve high accuracy in such applications. However, compared with dual-frequency receivers, it is much more difficult to resolve the integer ambiguity vector using single-frequency phase measurements and therefore more difficult to achieve reliable high-precision navigation. This paper presents a real-time sliding-window estimator that tightly integrates differential GPS and an inertial measurement unit to achieve reliable high-precision navigation performance in GPS-challenged urban environments using low-cost single-frequency GPS receivers. Moreover, this paper proposes a novel method to utilize the phase measurements, without resolving the integer ambiguity vector. Experimental results demonstrate real-time position estimation performance at the decimeter level. Furthermore, the novel use of phase measurements improves the robustness of the estimator to pseudorange multipath error.
Face similarity space as perceived by humans and artificial systems

The performance of a local feature based system, using Gabor filters, and a global template matching based system, using a combination of PCA (principal component analysis) and LDA (linear discriminant analysis) was correlated with human performance on a recognition task involving 32 face images. Both systems showed qualitative similarities to human performance in that all but one of the calculated correlation coefficients were very or moderately high. The Gabor filter model seemed to capture human performance better than the PCA-LDA model since the coefficients for this model were higher for all examined conditions. These results indicate that the preservation of local feature based representation might be necessary to achieve recognition performance similar to that of humans.
Validation and Application of a Model of Oxygen Consumption and Diffusion During Photodynamic Therapy In Vitro

The photophysical parameters for the photosensitizer Pd(II) meso‐Tetra(4‐carboxyphenyl) porphine (PdT790) acquired in a previous study were incorporated into the PDT oxygen diffusion models for cell suspensions and cell monolayers. The time‐dependent phosphorescence signals generated by the diffusion models are shown to match signals previously measured by M.A.W. and M.S.P. when reasonable physical and photophysical parameters are used. Simulations were performed to investigate the effects of metabolic and photodynamic oxygen consumption rates on the PDT dose in each of the treatment geometries. It was found that in cell suspensions of <1 million cells per mL, PDT should not be inhibited by hypoxia if the photodynamic consumption rate is <1 mm s−1. For cell monolayers the optimal photodynamic oxygen consumption rate was found to depend on the metabolic rate of oxygen consumption. If cells remained well oxygenated in the absence of PDT, then maximum PDT dose was delivered with the lowest practical photodynamic oxygen consumption rate. Simulations of PDT treatments for multicell tumor spheroids showed that large anoxic cores develop within the spheroids and, as a consequence, less PDT dose is delivered in comparison with similar treatments in cell suspensions and cell monolayers.
From compression to compressed sensing

Can compression algorithms be employed for recovering signals from their underdetermined set of linear measurements? Addressing this question is the first step towards applying compression algorithms for compressed sensing (CS). In this paper, we consider a family of compression algorithms CR, parametrized by rate R, for a compact class of signals Q ⊂ Rn. The set of natural images and JPEG2000 at different rates are examples of Q and Cr, respectively. We establish a connection between the rate-distortion performance of CR, and the number of linear measurement required for successful recovery in CS. We then propose compressible signal pursuit (CSP) algorithm and prove that, with high probability, it accurately and robustly recovers signals from an underdetermined set of linear measurements.
Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation

We report the purification of a protease from tumor cells undergoing apoptosis that is involved in activating DNA fragmentation. Initial studies revealed that two inhibitors of serine proteases, N-1- tosylamide-2-phenylethylchloromethyl ketone and carbobenzoxy-Ala-Ala- borophe (DK120), suppressed tumor necrosis factor or ultraviolet (UV) light-induced DNA fragmentation in the U937 histiocytic lymphoma as well as UV light-induced DNA fragmentation in the BT-20 breast carcinoma, HL-60 myelocytic leukemia, and 3T3 fibroblasts. The protease was purified by affinity chromatography with DK120 as ligand and showed high activity on a synthetic substrate preferred by elastase-like enzymes (Ala-Ala-Pro-Val p-nitroanilide), but was inactive on the trypsin substrate, N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester, or the chymotrypsin substrate, Ala-Ala-Pro-Phe p-nitroanilide. The activity of the DK120-binding protease purified from U937 cells undergoing apoptosis was increased approximately 10-fold over that recovered from normal cells. Further purification to homogeneity by heparin-Sepharose affinity chromatography followed by reverse phase high-performance liquid chromatography revealed a single band of 24 kD on a silver-stained sodium dodecyl sulfate gel. In addition to protease activity, the purified enzyme induced DNA fragmentation into multiples of 180 basepairs in isolated U937 nuclei. These findings suggest the 24- kD protease is a novel enzyme that activates DNA fragmentation in U937 cells undergoing apoptosis.
Dietary shortcomings in children on a gluten-free diet.

BACKGROUND Coeliac disease (CD), or permanent gluten intolerance, is one of the most common chronic food-related diseases among children in Europe and the USA. The treatment is lifelong gluten-free diet (GFD) (i.e. the exclusion of wheat, rye and barley from the diet, which are important sources particularly of iron, dietary fibre and vitamin B). The present study aimed to evaluate dietary intakes of energy and nutrients in children and adolescents on GFD and compare these with intake of comparable age groups on a normal diet as well as current recommendations. METHODS Thirty children, 4-17 years of age with confirmed CD and on GFD were agreed to participate in this study at the Department of Pediatrics, Umeå University Hospital. Weight and height were used to calculate individual energy requirement according to Nordic Nutrition Recommendations 2004 (NNR-04). Dietary intake was assessed using 5-day food records and household measures were used for quantities. Twenty-five children completed their dietary record. RESULTS Thirteen of the 25 children did not meet the recommended energy intake and the dietary intakes were inadequate regarding quality of macronutrients and quantity of minerals and vitamins. The mean intakes of sucrose and saturated fatty acids were above and the intakes of dietary fibre, vitamin D, magnesium and selenium below the NNR-04. High intakes of sucrose and saturated fat and a low intake of dietary fibre were also noted in a previous national survey on healthy children on a normal diet. The nutrient density of vitamin D, riboflavin, niacin, thiamine, magnesium and selenium were lower among CD children than healthy children but, for iron and calcium, it was higher in CD children. CONCLUSIONS Children on GFD appear to follow the same trends as healthy children on a normal diet, with high intakes of saturated fat and sucrose and low intakes of dietary fibre, vitamin D and magnesium compared to recommendations.
Multivariate Diophantine equations with many solutions

Among other things we show that for each n-tuple of positive rational numbers (a_1,., a_n) there are sets of primes S of arbitrarily large cardinality s such that the solutions of the equation a_1x_1+. +a_nx_n=1 with x_1,. ,x_n S-units are notcontained in fewer than exp((4+o(1)) s^{1/2} (log s)^{-1/2} proper linear subspaces of C^n. This generalizes a result of Erdos, Stewart and Tijdeman for S-unit equations in two variables. Further, we prove that for any algebraic number field K of degree n, any integer m with 1<= m<n, and any sufficiently large s there are integers b_0,. ,b_min K which are linearly independent over the rationals, and prime numbers p_1,. ,p_s, such that the normpolynomial equation|N_{K/\Q}(b_0+b_1x_1+. +b_mx_m)|=p_1^{z_1}. p_s^{z_s} has at leastexp(1+o(1)){n/m}s^{m/n}(\log s)^{-1+m/n}solutions in integers x_1,. ,x_m,z_1,. ,z_s. This generalizes a result of Moree and Stewart for m=1. Our main tool, also established in this paper, is an effective lower bound for the number of ideals in a number field K of norm <=X composed of prime ideals which lie outside a given finite set of prime ideals T and which have norm <=Y. This generalizes results of Canfield, Erdos and Pomerance and of Moree and Stewart.
Wide spectrum of desmosomal mutations in Danish patients with arrhythmogenic right ventricular cardiomyopathy

Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a lethal condition characterised by ventricular tachyarrhythmias, right and/or left ventricular involvement and fibrofatty infiltrations in the myocardium. The disease has been associated with mutations in genes encoding desmosomal proteins. Objective To thoroughly evaluate an ARVC cohort for desmosomal mutations and large genomic rearrangements and characterise the phenotype associated with double-mutation carrier status. Methods 65 unrelated patients (55 fulfilling current criteria and 10 borderline cases) were screened for mutations in all known desmosome genes (desmocollin-2 (DSC2), desmoglein-2 (DSG2), desmoplakin (DSP), plakoglobin (JUP) and plakophilin-2 (PKP2)) and TGFb3. Presence of genomic rearrangements was assessed by multiplex ligation-dependent probe amplification. Results The screening identified 19 different mutations: two mutations in DSG2, four in DSC2, two in DSP (one heterozygous and one homozygous), four in JUP (one patient with compound heterozygous) and seven in PKP2. No genomic rearrangements or mutations in TGFb3 were identified. Ten of the mutations were novel. Seven families carried more than one mutation. Clinical evaluation of these families showed a variable phenotype associated with the double-mutation carrier status. The homozygous desmoplakin mutation (DSP p.G2056R+p.G2056R) carrier came from a consanguineous Danish family and had left ventricular involvement, palmar keratoderma and curly hair consistent with a Carvajal-like syndrome. Conclusions 33% of patients in this Danish cohort with ARVC carried desmosomal mutations with a surprisingly wide mutation spectrum. A substantial proportion of patients carried more than one mutation. Our study supports comprehensive desmosomal mutation screening beyond the first encountered mutation, whereas routine screening for genomic rearrangements does not seem indicated.
Utility Optimization for Event-Driven Distributed Infrastructures

Event-driven distributed infrastructures are becoming increasingly important for information dissemination and application integration. We examine the problem of optimal resource allocation for such an infrastructure composed of an overlay of nodes. Resources, like CPU and network bandwidth, are consumed by both message flows and message consumers; therefore, we consider both rate control for flows and admission control for consumers. This makes the optimization problem difficult because the objective function is nonconcave and the constraint set is nonconvex. We present LRGP (Lagrangian Rates, Greedy Populations), a scalable and efficient distributed algorithm to maximize the total system utility. The key insight of our solution involves partitioning the optimization problem into two types of subproblems: a greedy allocation for consumer admission control and a Lagrangian allocation to compute the flow rates, and linking the subproblems in a manner that allows tradeoffs between consumer admission and flow rates while satisfying the nonconvex constraints. LRGP allows an autonomic approach to system management where nodes collaboratively optimize aggregate system performance. We evaluate the quality of results and convergence characteristics under various workloads.
INTERMETALLIC COMPOUND FORMATION AT THE INTERFACE OF THE DIFFUSION BONDED JOINTS TI-4.5AL-2MO-1.8V-0.5FE AND AISI 410 STAINLESS STEEL

The present study discusses the formation of interfacial reaction products in the dissimilar diffusion bonded joints made between AISI 410 and Ti-4.5Al-2Mo-1.8V-0.5 Fe (Ti-alloy). Diffusion bonding was carried out in the temperature range of 800 -900 o C with an interval of 50 o C, holding time 45min and a pressure of 8 MPa. A maximum shear strength of 64.2 MPa was obtained for the diffusion bonded joints processed at a temperature 850 o C, holding time 45min and 8 MPa pressure. Optical and SEM images revealed a distinct diffused region rich with intermetallic compounds at the interface. The EDAX and XRD performed at the interface corroborated the presence of intermetallic compounds and carbides such as Fe 2 Ti, Ti 2 Al, FeAl 2 , Fe 3 MoSi, TiAl, TiFe, MoSi 2 , FeCrAl, CrC, VC and, TiC.
for the lumber-drying process A singular pencil model and neural network cascade fault diagnosis strategy

This paper presents some results that were obtained in fault diagnosis for a wood-drying process. It is diffcult to detect and diagnose faults or failure in the drying process due to complex dynamic nonlinearity, coupling effects among key variables, and process disturbances caused by the variation of lumber sizes, species and environmental factors. In this paper, a real-time fault diagnosis algorithm is developed based on a singular pencil model and neural network classiier. Inputs of the network are the process I/O data, such as moisture and temperature, and estimated parameters and states, while outputs of the network are process fault situations. A wood-drying kiln is studied as a test case, which is with two actuators and 23 sensors, six estimated parameters and states, and 11 fault situations. The simulation results show that the strategy appears to be better suited to diagnose faults of such industrial processes.
Concentration-dependent effect of bleaching agents on microhardness and roughness of enamel and dentin.

PURPOSE To evaluate the microhardness and surface roughness of enamel and root dentin bleached with 10%, 15% and 22% carbamide peroxide agents. METHODS 52 slabs of enamel and root dentin (6 x 3 x 2 mm) were cut from bovine incisors, ground flat and polished. According to a randomized complete block design, enamel and root dentin slabs (n = 13) were independently allocated to be bleached with one of the following carbamide peroxide-containing agents (CP): 10% (Rembrandt Bleaching Gel Plus), 15% (Rembrandt Xtra Comfort), or 22% (Rembrandt Xtra Comfort Ultra Strength). The control groups were mock-treated with artificial saliva. The bleaching procedures consisted of daily application of the agents on dental substrate surfaces for 2 hours, followed by immersion in artificial saliva for 22 hours over 21 days. Knoop microhardness and surface roughness were measured initially, on sound dental tissues, and at the postbleaching phase. RESULTS In enamel, microhardness attained after bleaching with 10% CP and 15% CP were similar and significantly lower than that observed for the control group. Specimens bleached with CP 22% did not differ from any of the other groups tested. In root dentin, microhardness changes were indistinguishable. ANOVA showed no significant difference among treatments with respect to surface roughness.
Autism spectrum disorders in young children: effect of changes in diagnostic practices.

BACKGROUND It is unclear whether the increase in autism over the past two decades is a real increase or due to changes in diagnosis and ascertainment of autism spectrum disorders (ASDs), which include autism, Asperger syndrome and pervasive developmental disorder not otherwise specified (PDD-NOS). The aim of this study was to examine the trends in ASD over time in Western Australia (WA) and the possible effects and contribution of changes in diagnostic criteria, age at diagnosis, eligibility for service provision based on ASD diagnoses and changes in diagnostic practices. METHODS A population-based study was conducted among the cohort of children born in WA between 1983 and 1999 and diagnosed with ASD between the age of 2 and 8 years up to December 31, 2004. The trend in ASD diagnosis over the study period was assessed by investigating birth cohort and period effects, and examining whether these were modified by age of diagnosis. ASD diagnosis corresponding with changes in diagnostic criteria, funding and service provision over time were also investigated. A subgroup analysis of children aged <or=5 years was also conducted to examine trends in the incidence and age of diagnosis of ASD and intellectual disability (ID) and to investigate the role of changes in diagnostic practices. RESULTS The overall prevalence of ASD among children born between 1983 and 1999 and diagnosed by age 8 was 30 per 10,000 births with the prevalence of autism comprising 21 per 10,000 births. The prevalence of ASD increased by 11.9% per annum, from 8 cases per 10,000 births in 1983 to 46 cases per 10,000 births in 1999. The annual incidence of ASD, based on newly diagnosed ASD cases in each year from 1985 to 2002, increased over the study period. The increase in incidence of ASD appeared to coincide with changes in diagnostic criteria and availability of funding and services in WA, particularly for children aged <5 years. The age-specific rates of autism and PDD-NOS increased over time and the median age of diagnosis for autism decreased from 4 to 3 years of age throughout the 1990s. For children aged <or=5 years the incidence of ASD diagnosis increased significantly from 1992, with an average annual increase of 22%. Similar findings were found for autism. In the corresponding years the incidence of diagnosis of severe ID fell by 10% per annum and mild-moderate ID increased by 3% per annum. CONCLUSIONS The rise in incidence of all types of ASDs by year of diagnosis appears to be related to changes in diagnostic and service provision practices in WA. In children aged <or=5 years, diagnosis of severe ID decreased, but mild-moderate ID increased during the study period. A true increase in ASD cannot be ruled out.
Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing.

OBJECTIVES Resistance to clarithromycin is the most important factor causing failure of Helicobacter pylori eradication. Although clarithromycin resistance is mainly associated with three point mutations in the 23S rRNA genes, it is unclear whether other mutations are associated with this resistance. METHODS Two types of clarithromycin-resistant strains (low- and high-resistance strains) were obtained from clarithromycin-susceptible H. pylori following exposure to low clarithromycin concentrations. The genome sequences were determined with a next-generation sequencer. Natural transformation was used to introduce the candidate mutations into strain 26695. Etest and an agar dilution method were used to determine the MICs. RESULTS High-resistance strains contained the mutation A2143G in the 23S rRNA genes, whereas low-resistance strains did not. There were seven candidate mutations in six genes outside of the 23S rRNA genes. The mutated sequences in hp1048 (infB), hp1314 (rpl22) and the 23S rRNA gene were successfully transformed into strain 26695 and the transformants showed an increased MIC of and low resistance to clarithromycin. The transformants containing a single mutation in infB or rpl22 (either a 9 bp insertion or a 3 bp deletion) or the 23S rRNA gene showed low MICs (0.5, 2.0, 4.0 and 32 mg/L, respectively) while the transformants containing double mutations (mutation in the 23S rRNA genes and mutation in infB or rpl22) showed higher MICs (>256 mg/L). CONCLUSIONS Next-generation sequencing can be a useful tool for screening mutations related to drug resistance. We discovered novel mutations related to clarithromycin resistance in H. pylori (infB and rpl22), which have synergic effects with 23S rRNA resulting in higher MICs.
Developmental psychopathology: The role of structural variation in the genome

Abstract A wide range of developmental disorders present with characteristic psychopathologies and behaviors, with diagnoses including, inter alia, cognitive disorders and learning disabilities, epilepsies, autism, and schizophrenia. Each, to varying extent, has a genetic component to etiology and is associated with cytogenetic abnormalities. Technological developments, particularly array-based comparative genome hybridization and single nucleotide polymorphism chips, has revealed a wide range of rare recurrent and de novo copy number variants (CNVs) to be associated with disorder and psychopathology. It is surprising that many apparently similar CNVs are identified across two or more disorders hitherto considered unrelated. This article describes the characteristics of CNVs and current technological restrictions that make accurately identifying small events difficult. It summarizes the latest discoveries for individual diagnostic categories and considers the implications for a shared neurobiology. It examines likely developments in the knowledge base as well as addressing the clinical implications going forward.
Normal Activation of Discoidin Domain Receptor 1 Mutants with Disulfide Cross-links, Insertions, or Deletions in the Extracellular Juxtamembrane Region

Background: DDR1 is a constitutively dimeric receptor tyrosine kinase that is activated by collagen. The mechanism of transmembrane signaling is unknown. Results: DDR1 activation is unaffected by disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region. Conclusion: The extracellular juxtamembrane region of DDR1 does not transmit a conformational change across the cell membrane. Significance: The activation mechanism of DDR1 appears to be unique among receptor tyrosine kinases. The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by collagen. DDR activation does not appear to occur by the common mechanism of ligand-induced receptor dimerization: the DDRs form stable noncovalent dimers in the absence of ligand, and ligand-induced autophosphorylation of cytoplasmic tyrosines is unusually slow and sustained. Here we sought to identify functionally important dimer contacts within the extracellular region of DDR1 by using cysteine-scanning mutagenesis. Cysteine substitutions close to the transmembrane domain resulted in receptors that formed covalent dimers with high efficiency, both in the absence and presence of collagen. Enforced covalent dimerization did not result in constitutive activation and did not affect the ability of collagen to induce receptor autophosphorylation. Cysteines farther away from the transmembrane domain were also cross-linked with high efficiency, but some of these mutants could no longer be activated. Furthermore, the extracellular juxtamembrane region of DDR1 tolerated large deletions as well as insertions of flexible segments, with no adverse effect on activation. These findings indicate that the extracellular juxtamembrane region of DDR1 is exceptionally flexible and does not constrain the basal or ligand-activated state of the receptor. DDR1 transmembrane signaling thus appears to occur without conformational coupling through the juxtamembrane region, but requires specific receptor interactions farther away from the cell membrane. A plausible mechanism to explain these findings is signaling by DDR1 clusters.