Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards understanding vacuolar antioxidant mechanisms: a role for fructans?

Recent in vitro, in vivo, and theoretical experiments strongly suggest that sugar-(like) molecules counteract oxidative stress by acting as genuine reactive oxygen species (ROS) scavengers. A concept was proposed to include the vacuole as a part of the cellular antioxidant network. According to this view, sugars and sugar-like vacuolar compounds work in concert with vacuolar phenolic compounds and the ‘classic’ cytosolic antioxidant mechanisms. Among the biologically relevant ROS (H2O2, O2·–, and ·OH), hydroxyl radicals are the most reactive and dangerous species since there are no enzymatic systems known to neutralize them in any living beings. Therefore, it is important to study in more detail the radical reactions between ·OH and different biomolecules, including sugars. Here, Fenton reactions were used to compare the ·OH-scavenging capacities of a range of natural vacuolar compounds to establish relationships between antioxidant capacity and chemical structure and to unravel the mechanisms of ·OH–carbohydrate reactions. The in vitro work on the ·OH-scavenging capacity of sugars and phenolic compounds revealed a correlation between structure and ·OH-scavenging capacity. The number and position of the C=C type of linkages in phenolic compounds greatly influence antioxidant properties. Importantly, the splitting of disaccharides and oligosaccharides emerged as a predominant outcome of the ·OH–carbohydrate interaction. Moreover, non-enzymatic synthesis of new fructan oligosaccharides was found starting from 1-kestotriose. Based on these and previous findings, a working model is proposed describing the putative radical reactions involving fructans and secondary metabolites at the inner side of the tonoplast and in the vacuolar lumen.
Tenure and Experience Effects on Wages: A Theory

This paper investigates equilibria in a labor market where firms post wage/tenure contracts and risk-averse workers, both employed and unemployed, search for better paid job opportunities. Different firms typically offer different contracts. Workers accumulate general human capital through learning-by-doing. With on-the-job search, a worker’s wage evolves endogenously over time through experience effects, tenure effects and quits to better paid employment. This equilibrium approach suggests how to identify econometrically between experience and tenure effects on worker wages.
OECD Comparative Economic Growth 1950-85: Catch-Up and Convergence

The apparent convergence of OECD income levels since 1950 is subjected to rigorous testing that suggests that there has occurred a systematic process of catching up in levels of total factor productivity. An econometric model of relative economic growth exhibits parameter stability over three decades, including the period after 1973, and statistical robustness, particularly with respect to sample selection. A reassessment is made of OECD comparative economic growth performance. Copyright 1989 by American Economic Association.
Do soccer players play the mixed-strategy Nash equilibrium?

Mixed-Strategy Nash Equilibrium (MSNE) is a commonly used solution concept in game-theoretic models in various fields in economics, management and other disciplines, but the experimental results whether the MSNE predicts well actual play in games is mixed. Consequently, the evidence for naturally occurring games in which the MSNE predicts the outcome well is of great importance, as it can justify the vast use of MSNE in models. The game between the kicker and the goalkeeper in soccer penalty kicks is a real-world game that can be used to examine the application of the MSNE concept or its accuracy, because payoffs are a common knowledge, the players have huge incentives to play correctly, the game is simple enough to analyse, its Nash equilibrium is in mixed strategies, and players’ actions can be observed. We collected and analysed the data on the direction of kicks and jumps in penalty kicks in various top leagues and tournaments. Our analysis suggests that the MSNE predictions are the closest to the actual sample data, even though some other prediction methods use information on the marginal distribution of kicks or jumps, whereas the MSNE does not.
Viscoelastic Effects on the Entropy Production in Oscillatory Flow between Parallel Plates with Convective Cooling

The heat transfer problem of a zero-mean oscillatory flow of a Maxwell fluid between infinite parallel plates with boundary conditions of the third kind is considered. With these conditions, the amount of heat entering or leaving the system depends on the external temperature as well as on the convective heat transfer coefficient. The local and global time-averaged entropy production are computed, and the consequences of convective cooling of the plates are also assessed. It is found that the global entropy production is a minimum for certain suitable combination of the physical parameters. For a discrete set of values of the oscillatory Reynolds number, the extracted heat from one of the plates shows maxima.
Urban regeneration in the UK

Chapter 1: Introduction Defining 'urban regeneration' The scale of change From boom to bust Chapter 2: Policy Framework Introduction: origins of the neoliberal shift Innovations during the New Labour period, 1997-2010 Contemporary policy in England Devolution Chapter 3: Governance Definition: from government to governance Understanding the state Different forms of governance The new institutionalism Community involvement Regional regeneration and the European Union Chapter 4: The Competitive City Deindustrialisation and the competitive city Funding economic regeneration Regenerating cities in practice The financial crisis and its impact on regeneration funding The entrepreneurial city Chapter 5: Sustainability Sustainable development and regeneration The policy framework Social sustainability The brownfield development agenda Climate change, cities and carbon Sustainable construction Chapter 6: Design and Cultural Regeneration The urban design agenda Cultural regeneration Chapter 7: Regeneration Beyond the City Centre The suburban question Regenerating social housing suburbs New build suburbs The great eco-towns disaster Chapter 8: Scaling up London Olympics 2012 Mega-regeneration in the Thames Gateway Chapter 9: Conclusions Glossary
Calculation of Average Power, Leakage Power, and Leakage Current of FinFET Based 4-Bit Priority Encoder

A 4-input, 3-output priority encoder, implemented in Hardware, often serves as a polling device that permits access to a single (hardware) resource whenever access requests initiated by multiple devices are received at its inputs, either on-chip or Off-chip. In this context, the design of a 4-bit (4-inputs and 3-outputs) FinFET priority encoder module, suitable for embedded system applications is presented in this work and it is found from Cadence simulations that the 4-bit dynamic FinFET priority encoder Average power dissipation is 11.56 nW, Leakage Current 26.19 pA and Leakage Power 131.1pW.
Ownership structure, board composition and corporate voluntary disclosure: Evidence from listed companies in China

Purpose – The paper aims to examine the impact of ownership structure and board composition on voluntary disclosures of listed companies in China.Design/methodology/approach – Using an OLS‐regression model to test the relationship among ownership structure, board composition and the level of voluntary disclosure. The sample is based on 559 firm observations in 2002.Findings – Higher blockholder ownership and foreign listing/shares ownership is associated with increased disclosure. However, managerial ownership, state ownership, and legal‐person ownership are not related to disclosure. An increase in independent directors increases corporate disclosure and CEO duality is associated with lower disclosure. The paper also finds that larger firms had greater disclosure, while firms with growth opportunities are reluctant to disclose information voluntarily.Research limitations/implications – Firstly, the sample is comprised of companies listed on Shanghai Stock Exchange in 2002 and only 45.7 percent of represe.
Analyzing and recognizing walking figures in XYT

We describe a novel algorithm for gait analysis. A person walking frontoparallel to the image plane generates a characteristic "braided" pattern in a spatiotemporal (XYT) volume. Our algorithm detects this pattern, and fits it with a set of spatiotemporal snakes. The snakes can be used to find the bounding contours of the walker. The contours vary over time in a manner characteristic of each walker. Individual gaits can be recognized by applying standard pattern recognition techniques to the contour signals. <<ETX>>
Financing innovation in the United States, 1870 to the present

Although technological change is vital for economic growth, the interaction of finance and technological innovation is rarely studied. This pioneering volume examines the ways in which innovation is funded in the United States. In case studies and theoretical discussions, leading economists and economic historians analyze how inventors and technologically creative entrepreneurs have raised funds for their projects at different stages of U.S. economic development, beginning with the post-Civil War period of the Second Industrial Revolution. Their discussions point to intriguing insights about how the nature of the technology may influence its financing and, conversely, how the availability of funds influences technological advances. These studies show that over the long history of American technological advancement, inventors and innovators have shown considerable flexibility in finding ways to finance their work. They have moved to cities to find groups of local investors; they have worked for large firms that could tap the securities market for funds; they have looked to the federal government for research and development funding; and they have been financed by the venture capital industry. The studies make it clear that methods of funding innovation--whether it is in the auto industry or information technology--have important implications for both the direction of technological change and the competitive dynamism of the economy.
Positive nuclear BAP1 immunostaining helps differentiate non-small cell lung carcinomas from malignant mesothelioma

The differential diagnosis between pleural malignant mesothelioma (MM) and lung cancer is often challenging. Immunohistochemical (IHC) stains used to distinguish these malignancies include markers that are most often positive in MM and less frequently positive in carcinomas, and vice versa. However, in about 10–20% of the cases, the IHC results can be confusing and inconclusive, and novel markers are sought to increase the diagnostic accuracy. We stained 45 non-small cell lung cancer samples (32 adenocarcinomas and 13 squamous cell carcinomas) with a monoclonal antibody for BRCA1-associated protein 1 (BAP1) and also with an IHC panel we routinely use to help differentiate MM from carcinomas, which include, calretinin, Wilms Tumor 1, cytokeratin 5, podoplanin D2-40, pankeratin CAM5.2, thyroid transcription factor 1, Napsin-A, and p63. Nuclear BAP1 expression was also analyzed in 35 MM biopsies. All 45 non-small cell lung cancer biopsies stained positive for nuclear BAP1, whereas 22/35 (63%) MM biopsies lacked nuclear BAP1 staining, consistent with previous data. Lack of BAP1 nuclear staining was associated with MM (two-tailed Fisher's Exact Test, P = 5.4 × 10−11). Focal BAP1 staining was observed in a subset of samples, suggesting polyclonality. Diagnostic accuracy of other classical IHC markers was in agreement with previous studies. Our study indicated that absence of nuclear BAP1 stain helps differentiate MM from lung carcinomas. We suggest that BAP1 staining should be added to the IHC panel that is currently used to distinguish these malignancies.
Lyman Break Galaxies at Redshift z ~ 3: Survey Description and Full Data Set

We present the basic data for a large ground-based spectroscopic survey for z ~ 3 Lyman break galaxies (LBGs), photometrically selected using rest-UV colors from very deep images in 17 high Galactic latitude fields. The total survey covers an area of 0.38 deg2 and includes 2347 photometrically selected candidate LBGs to an apparent ℛAB magnitude limit of 25.5. Approximately half of these objects have been observed spectroscopically using the Keck telescopes, yielding 940 redshifts with ⟨z⟩ = 2.96 ± 0.29. We discuss the images, photometry, target selection, and spectroscopic program in some detail and present catalogs of the photometric and spectroscopic data, made available in electronic form. We discuss the general utility of conducting nearly volume-limited redshift surveys in prescribed redshift intervals using judicious application of photometric preselection.
ON THE INDUCTIVE ALPERIN – MCKAY AND ALPERIN WEIGHT CONJECTURE FOR GROUPS WITH

We study the inductive Alperin–McKay conjecture, the inductive Isaacs– Navarro refinement and the inductive blockwise Alperin weight conjecture for groups of Lie type in the generic case of abelian Sylow `-subgroups. We also show that the alternating groups, the Suzuki groups and the Ree groups satisfy the inductive condition necessary for Späth’s reduction of the blockwise Alperin weight conjecture to the case of simple groups.
Evaluation of the Effectiveness of a Psychoeducational Intervention in Treatment-Naïve Patients with Antidepressant Medication in Primary Care: A Randomized Controlled Trial

Background. There is evidence supporting the effectiveness of psychoeducation (PE) in patients with symptoms of depression in primary care (PC), but very few studies have assessed this intervention in antidepressant-naïve patients. The aim of this study is to assess the effectiveness of a PE program in these patients, since the use of antidepressant (AD) medication may interfere with the effects of the intervention. Methods. 106 participants were included, 50 from the PE program (12 weekly 1.5-hour sessions) and 56 from the control group (CG) that received the usual care. Patients were assessed at baseline and at 3, 6, and 9 months. The main outcome measures were the Beck Depression Inventory (BDI) and remission based on the BDI. The analysis was carried out on an intention-to-treat basis. Results. The PE program group showed remission of symptoms of 40% (P = 0.001) posttreatment and 42% (P = 0.012) at 6 months. The analysis only showed significant differences in the BDI score posttreatment (P = 0.008; effect size Cohen's d′ = 0.55). Conclusions. The PE intervention is an effective treatment in the depressive population not treated with AD medication. Before taking an AD, psychoeducational intervention should be considered.
Mesoscale optical turbulence simulations at Dome C

In recent years, ground-based astronomy has been looking towards Antarctica, especially its summits and the internal continental plateau, where the optical turbulence appears to be confined in a shallow layer close to the icy surface. Preliminary measurements have so far indicated rather good values for the seeing above 30–35 m: around 0.3 arcsec at Dome C. Site-testing campaigns are however extremely expensive; instruments provide only local measurements and atmospheric modelling might represent a step ahead in the search and selection of astronomical sites, thanks to the possibility of reconstructing three-dimensional (3D) C 2 maps over a surface of several km. The Antarctic Plateau therefore represents an important benchmark test to evaluate the possibility of discriminating between sites on the same plateau. Our group has proven that the analyses from the European Centre for Medium-Range Weather Forecasts (ECMWF) global model do not describe the Antarctic boundary and surface layers in the plateau with the required accuracy. A better description could be obtained with a mesoscale meteorological model. The mesoscale model Meso-NH has proven to be reliable in reproducing 3D maps of optical turbulence above mid-latitude astronomical sites. In this paper we study the ability of the Meso-NH model to reconstruct the meteorological parameters as well as the optical turbulence above Dome C with different model configurations (monomodel and grid-nesting). We concentrate our attention on the abilities of the model in reproducing the optical turbulence surface-layer thickness (hsl) and the integral of C 2 in the free atmosphere and in the surface layer. It is worth highlighting that these are the first estimates ever made with a mesoscale model of the optical turbulence above the internal Antarctic Plateau.
Object Depth Estimation from a Single Image Using Fully Convolutional Neural Network

Convolutional Neural Network (CNN) has been used successfully in solving different computer vision tasks such as classification, detection, and segmentation. This paper addresses the problem of estimating object depth from a single RGB image. While stereo depth estimation is a straightforward task, predicting depth map of an object from a single RGB image is a more challenging task due to the lack of information from various image cues. Prior work focuses on exploiting geometric information or hand-crafted features. Also, they proposed the L2 norm to perform the optimization of a CNN during the training process. Using the L2 norm in regression tasks for optimization will bias the model. To address this problem, we propose a regression model with a fully convolutional neural network. To achieve robustness to outliers, we optimize the model using Tukey's biweight loss function, which is an M-estimator that is robust against outliers. The predictions are given by a single fully CNN without any post-processing techniques. In our experiments, we show that the quantitative and the qualitative results of using Tukey's biweight loss for optimization are better than of using L2 norm.
Trust, risk and control within an indigenous–non-indigenous social service partnership

Partnerships between organisations are seen as one of the building blocks of the ‘third way’ approach to welfare provision in both Europe and New Zealand. While there is much discussion on building social capital and partnership working, such partnerships are usually perceived as being between government and community or private organisations. There is a gap in the literature in two specific areas: partnerships formed between two community-based social service organisations and partnerships formed between indigenous, or immigrant peoples, and non-indigenous organisations. This article explores such a partnership – that between the Ngai Tahu Maori Law Centre (an indigenous organisation) and the Dunedin Community Law Centre (a non-indigenous organisation). The article analyses this relationship and strategies employed by both organisations to develop trust, diminish risk and equalise control. Lastly, the article suggests that the model of interaction articulated here could be promulgated to other sites within the social services in New Zealand and the Americas, and within the European context.
What makes consumers buy from Internet? A longitudinal study of online shopping

The objective of this study is to investigate the factors affecting online shopping. A model explaining the impact of different factors on online shopping intentions and behavior is developed based on the theory of planned behavior. The model is then tested empirically in a longitudinal study with two surveys. Data collected from 705 consumers indicate that subjective norms, attitude, and beliefs concerning the consequences of online shopping have significant effects on consumers' intentions to buy online. Behavioral control and intentions significantly influenced online shopping behavior. The results also provide strong support for the positive effects of personal innovativeness on attitude and intentions to shop online. The implications of the findings for theory and practice are discussed.
Perspectives on Blended Learning in Higher Education

This article explores the benefits and challenges of blended learning in higher education from the perspective of students, faculty, and administration that have had direct experience with this form of course delivery. Students indicate that a blended learning model provides them with greater time flexibility and improved learning outcomes but that initially they encounter issues around time management, taking greater responsibility for their own learning, and using sophisticated technologies. Faculty suggest that blended courses create enhanced opportunities for teacher-student interaction, increased student engagement in learning, added flexibility in the teaching and learning environment, and opportunities for continuous improvement. They state that the challenges faced in developing such a course include a lack of time, support and resources for course redesign, acquiring new teaching and technology skills, plus the risks associated with delivering a course in a blended format. From an administrative perspective, blended learning presents the opportunity to enhance an institutions reputation, expand access to an institutions educational offerings, and reduce operating costs. The challenges consist of aligning blended learning with institutional goals and priorities, resistance to organizational change and lack of organizational structure and experience with collaboration and partnerships.
Interest Rate Parity and Monetary Integration: A Cointegration Analysis of Sweden and the EMU

This thesis provides a thorough analysis of the covered- and uncovered interest parity conditions (CIP, UIP) as well as the forward rate unbiasedness hypothesis (FRUH) for Sweden and the European Economic and Monetary Union (EMU). By studying data on interbank rates in Sweden (STIBOR) and the EMU (EURIBOR) as well as the corresponding spot- and forward exchange rates, monetary integration and country-specific risks are determined and analyzed with direct applications to the potential entry of Sweden into the EMU. As interest rate parity in general gives insight into market efficiency and frictions between the chosen regions, such points are discussed in addition to EMU entry. Drawing on past studies that mainly studied one condition in isolation, a nested formulation of interest rate parity is instead derived and tested using cointegration and robust estimation methods. The results point to a strict rejection of the FRUH for all horizons except the shortest and a case where CIP only holds for the 6-month horizon and partially over one year. This implies, based on the nested formulation, that UIP is rejected for all horizons as well. Ultimately, the study concludes that a Swedish entry into the EMU is not motivated given the lackluster results on UIP and due to the lack of monetary integration.
Age and Gender Differences in Beliefs about Personal Power and Injustice

College students and community-dwelling older adults were compared on Injustice and Personal Power scales and measures of religiosity. “Personal Power” scores varied significantly as a function of age and gender. These differences were attributable to a significantly lower belief in “Personal Power” for the group of older women. As predicted, “Injustice” scores were significantly higher for women than for men, reflecting a greater belief that conditions can be unjust. No significant difference between older and younger adults on “Injustice” scores was obtained. Significant positive correlations between measures of religiosity and “Injustice” scores were obtained, while religiosity was not significantly correlated with “Personal Power. ” This pattern of results suggests that there is value in utilizing separate measures of “Injustice” and “Personal Power” scores. Suggestions are made for examining further the complex relationship among demographic variables, belief in a just world, and measures of religiosity.