Miracle-dz/UniFAR-FTUs huggingface dataset:
Port-site metastasis as a primary complication following retroperitoneal laparoscopic radical resection of renal pelvis carcinoma or nephron-sparing surgery: A report of three cases and review of the literature

The present study reports the clinical data of two patients with renal pelvis carcinoma and one patient with renal carcinoma who developed port-site metastasis following retroperitoneal laparoscopic surgery. The current study aimed to identify the cause and prognosis of the occurrence of port-site metastasis subsequent to laparoscopic radical resection of renal pelvis carcinoma and nephron-sparing surgery. Post-operative pathology confirmed the presence of high-grade urothelial cell carcinoma in two patients and Fuhrman grade 3 renal clear cell carcinoma in one patient. Port-site metastasis was initially detected 1–7 months post-surgery. The two patients with renal pelvis carcinoma succumbed to the disease 2 and 4 months following the identification of the port-site metastasis, respectively, whereas the patient with renal carcinoma survived with no disease progression during the targeted therapy period. The occurrence of port-site metastasis may be attributed to systemic and local factors. Measures to reduce the development of this complication include strict compliance with the operating guidelines for tumor surgery, avoidance of air leakage at the port-site, complete removal of the specimen with an impermeable bag, irrigation of the laparoscopic instruments and incisional wound with povidone-iodine when necessary, and enhancement of the body's immunity. Close post-operative follow-up observation for signs of recurrence or metastasis is essential, and systemic chemotherapy may be required in patients with high-grade renal pelvis carcinoma and renal carcinoma in order to prolong life expectancy.
Toward Understanding Remote Workers’ Management of Work–Family Boundaries: The Complexity of Workplace Embeddedness

This study employs a multi-method research design to examine how remote workers, or employees who work solely from home, manage the work–family interface. Our qualitative study revealed that working from home creates unique challenges for remote workers because the work role becomes embedded in the family domain such that their home comes to be associated with the work role, work physically and psychologically intrudes upon their family, and habits and norms form that induce remote workers to be preoccupied with work when home. Based on the qualitative findings, a model was proposed and tested via a questionnaire. Findings from this study of remote workers demonstrated that work–family integration increases family-to-work conflict and work-to-family conflict, and that an inability to disengage from work increases work-to-family conflict. Furthermore, strong work–family integration was found to be particularly harmful to male remote workers’ work-to-family conflict whereas a strong inability to disengage from work was found to be particularly harmful to female remote workers’ work-to-family conflict. Our findings therefore revealed that working solely from home encourages remote workers to overwork and to allow their work to infringe on their family role.
Finite-Time-Convergent Differentiator Based on Singular Perturbation Technique

A finite-time-convergent differentiator is presented that is based on singular perturbation technique. The merits of this differentiator exist in three aspects: rapidly finite-time convergence compared with other typical differentiators; no chattering phenomenon; and besides the derivatives of the derivable signals, the generalized derivatives of some classes of signals can be obtained-for example, the generalized derivative of a triangular wave is square wave, etc. The theoretical results are confirmed by computer simulations.
Neurobiological Systems for Lexical Representation and Analysis in English

Current research suggests that language comprehension engages two joint but functionally distinguishable neurobiological processes: a distributed bilateral system, which supports general perceptual and interpretative processes underpinning speech comprehension, and a left hemisphere (LH) frontotemporal system, selectively tuned to the processing of combinatorial grammatical sequences, such as regularly inflected verbs in English [Marslen-Wilson, W. D. , & Tyler, L. K. Morphology, language and the brain: The decompositional substrate for language comprehension. Philosophical Transactions of the Royal Society: Biological Sciences, 362, 823–836, 2007]. Here we investigated how English derivationally complex words engage these systems, asking whether they selectively activate the LH system in the same way as inflections or whether they primarily engage the bilateral system that support nondecompositional access. In an fMRI study, we saw no evidence for selective activation of the LH frontotemporal system, even for highly transparent forms like bravely. Instead, a combination of univariate and multivariate analyses revealed the engagement of a distributed bilateral system, modulated by factors of perceptual complexity and semantic transparency. We discuss the implications for theories of the processing and representation of English derivational morphology and highlight the importance of neurobiological constraints in understanding these processes.
A Framework for Interactive Mindfulness Meditation Using Attention-Regulation Process

We are often overwhelmed by everyday stressors. Mindfulness meditation can help slow things down and bring one's attention into the present moment. Given the prevalence of smartphones, mindfulness-based mobile applications (MBMAs) have received much attention. Current MBMAs mainly use the guided meditation method which may not be always effective, e.g., users may not be able to follow the pace of instructions and they need a private environment. This paper presents a framework for interactive MBMAs which allows users to self-regulate their attention according to their abilities and conditions. The framework is described by an Attention-Regulation Process and has two components: (1) Relaxation Response and (2) Attention Restoration Theory. The framework is validated by our experiment. It also informs future development for interactive meditation and has broad implications for designing mindfulness and well-being.
The crossover of positive and negative emotions: The role of state empathy.

Tel Aviv UniversityOur aims were (a) to provide empirical support for the crossover process andcompare positive and negative crossover intensity, and (b) to establish therole of state empathy in the crossover process. Participants were 62 armytrainees participating in a training course in the Israeli Defense Forces(IDF). We manipulated crossover by presenting a distressed or a happytarget person creating negative (distressed target person) and positive(happy target person) conditions. Participants’ affect was assessed usingself-report questionnaires and cognitive tasks. Results support the operationof positive and negative crossover from a target person to the trainees.Findings indicate a relative dominance of positive over negative crossover.The hypothesis that emotions cross over as a result of empathy was partiallysupported. We found that the condition (positive-happy or negative-distressed target person) had a stronger impact among respondents charac-terized by high state empathy only for positive emotions.
Nonlinear piezoelectricity in electroelastic energy harvesters: Modeling and experimental identification

We propose and experimentally validate a first-principles based model for the nonlinear piezoelectric response of an electroelastic energy harvester. The analysis herein highlights the importance of modeling inherent piezoelectric nonlinearities that are not limited to higher order elastic effects but also include nonlinear coupling to a power harvesting circuit. Furthermore, a nonlinear damping mechanism is shown to accurately restrict the amplitude and bandwidth of the frequency response. The linear piezoelectric modeling framework widely accepted for theoretical investigations is demonstrated to be a weak presumption for near-resonant excitation amplitudes as low as 0.5 g in a prefabricated bimorph whose oscillation amplitudes remain geometrically linear for the full range of experimental tests performed (never exceeding 0.25% of the cantilever overhang length). Nonlinear coefficients are identified via a nonlinear least-squares optimization algorithm that utilizes an approximate analytic solution obta.
Anxiety, emotional reactivity, and attachment as predictors of embedding dimensionality of affect

In this study we investigated individual differences in emotionality and affect dynamics in couples over 21 days using a modified version of the False Nearest Neighbors method to estimate the embedding dimensionality of positive and negative affect. We estimated the number of dynamic degrees of freedom contributing to changes observed in time series’ of affect. Patterns in daily affect may reflect an additive impact of stimuli (attending to many unique influences, high dimensionality) or a coordinative process that recruits stimuli (hyper-focus, low dimensionality). We examined the relationship between the embedding dimensionality of affect and macroscopic descriptors of emotionality that bear on affect regulation and appraisal processes. Associations were found for negative affect only. Higher levels of trait anxiety, emotional reactivity, and attachment anxiety were associated with lower dimensionality, regardless of the occurrence of daily negative events. The findings were consistent with the hyper-focus hypothesis. Individuals low in negative emotionality had high dimensionality except when they reported greater frequency of daily negative events. The pattern of results is discussed with respect to flexibility in affect regulation.
Lichen planopilaris: retrospective study and stepwise therapeutic approach.

son. Acquisition of data: Robinson and Ortiz. Drafting of the manuscript: Robinson. Critical revision of the manuscript for important intellectual content: Ortiz. Obtained funding: Robinson. Administrative, technical, and material support: Ortiz. Study supervision: Robinson. Financial Disclosure: None reported. Funding/Support: This study was supported by grant 5R21 CA-103833-02 from the National Cancer Institute (Dr Robinson). Additional Contributions: Rob Turrisi, PhD, performed the statistical analysis for this study. Disclaimer: Dr Robinson was not involved in the editorial evaluation or editorial decision to accept this work for publication.
The T Cell Response to the Contact Sensitizer Paraphenylenediamine Is Characterized by a Polyclonal Diverse Repertoire of Antigen-Specific Receptors

Paraphenylenediamine (PPD) is a common component of hair dyes and black henna tattoos and can cause skin sensitization and allergic contact dermatitis (ACD). The cutaneous inflammatory reaction associated with ACD is driven by both CD4+ and CD8+ T cells. However, the characteristics of such responses with respect to clonal breadth and magnitude are poorly defined. In this study, we have characterized the in vitro recall response of peripheral blood T cells prepared from PPD-allergic individuals to a PPD–human serum albumin (HSA) conjugate (PPD–HSA). Quantitative high throughput sequencing was used to characterize the changes in the repertoire of T cell receptor (TCR) α and β genes after exposure to antigen in vitro. The PPD conjugate induced expansion of T cells carrying selected TCRs, with around 800 sequences (around 1%) being 8 or more times as abundant after culture than before. The expanded sequences showed strong skewing of V and J usage, consistent with an antigen-driven clonal expansion. The complementarity-determining region 3 sequences of the expanded TCRs could be grouped into several families of related amino acid sequence, but the overall diversity of the expanded sample was not much less than that of a random sample of the same size. The results suggest a model in which PPD–HSA conjugate stimulates a broad diversity of TCRs, with a wide range of stimulation strengths, which manifest as different degrees of in vitro expansion.
Connecting Activists and Journalists

This article examines how feminist activists, women's organizations, and journalists in India connected with each other through Twitter following the gang rape incident in New Delhi in December 2012. First, the investigation draws on a set of +15 million tweets specifically focused on rape and gang rape. These tweets, which appeared between 16 January 2013 and 16 January 2014, were collected and analysed with the DMI Twitter Capture and Analysis Toolset. Second, to gain further insight into how Twitter enables and shapes civil society connections, the article builds on 15 semi-structured interviews with Indian feminist activists and journalists, who actively participated in Twitter communication on the gang rape incident. The analysis of the Twitter and interview data reveals how the platform allows these actors to make ad hoc connections around particular protest issues and events. These connections alter both activist and journalist practices, and ultimately facilitate the current transformation of public discourse on gender violence. Twitter helps to keep this issue consistently on the front burner. In this sense, a significant shift from the past has occurred, when media coverage typically died out after an incident ceased to be news. Yet, our study also suggests that connectivity is tempered by Twitter's limited Indian user base, and users’ focus on the “crime of the day. ”
Impact of intracoronary injection of CD133+ bone marrow stem cells on coronary atherosclerotic progression in patients with STEMI: a COMPARE-AMI IVUS substudy

ObjectivesAdverse effects of intracoronary injection of stem cells on in-stent restenosis and atherosclerotic progression remain unclear. We sought to evaluate the adverse effects of intracoronary injection of CD133+ cells on in-stent restenosis and atherosclerotic progression in the infarct-related and contralateral arteries using serial intravascular ultrasound (IVUS) analysis. MethodsBaseline and 4-month follow-up IVUS images were obtained from 17 patients treated with intracoronary stem cell injection and 20 placebo patients after primary percutaneous coronary intervention in the COMPARE-AMI trial. In the infarct-related artery, the stented segment, 5 mm proximal and distal reference segments, and proximal and distal nonstented segments were analyzed every 1 mm; the entire segment of a contralateral artery was also analyzed every 1 mm. ResultsIn the infarct-related artery analysis, the median percentage of in-stent neointimal hyperplasia (12.1 vs. 7.6%, P=0.95), the reduction in the minimum lumen area (MLA; −1.6 vs. −1.5 mm2, P=0.97), and the MLA at follow-up (4.3 vs. 5.3 mm2, P=0.21) were found to be similar between the stem cell and placebo groups. Changes in proximal and distal nonstented segment lumen areas and plaque burden were also similar between the stem cell and placebo groups; however, there was a decrease in the maximum arc of the attenuated plaque behind the stent from baseline to follow-up in the placebo group (P=0.004), but not in the stem cell group. In the contralateral artery, there were no differences in changes in MLA, plaque burden, or attenuated plaque between stem cell and placebo patients. ConclusionIntracoronary injection of CD133+ bone marrow stem cells has no IVUS-detectable effect on neointimal hyperplasia or atherosclerosis progression in either infarct-related or contralateral arteries.
Integrating the Individual and the Organisation

The emphasis on organizational change in the corporate life of recent years-including job redesign, autonomous groups, high performance work systems, and the redesign of control systems-owes a great deal to the pioneering work of Chris Argyris. This book examines how individuals in organizations can become more effective, in turn making organizations more effective. It explores the conventional pyramidal structure of organizations, in which there is top-down control by managers over workers, and examines their negative consequences. These include organizational injustice and eventually irrational decision-making. Argyris also discusses the characteristic learning system of the modern organization, which he describes as "single-loop" in character. This system, he argues, is only adequeate enough to permit the organization to implement existing policies. It does not permit the more difficult and comprehensive task of questioning underlying goals and assumptions, which he terms "doubt loop" learning. In this kind of learning, the organization is able to confront the more difficult problems that affect organizations in a time of transition. In his new introduction, Argyris reviews the strengths and limitations of the argument advanced in "Integrating the Individual and the Organization. "He describes why the pyramidal structure endures, and why creating a self-learning organization is an even more challenging task than he has imagined. The book will be of interest to professionals with a long-standing interest in organizational development as well as those just entering the field, managers confronting the challenge of organization change, and researchers in organizational behavior and theory.
CLIL and Intercultural Communicative Competence: Foundations and Approaches towards a Fusion

One of the core developments of globalisation lies in the increased cooperation and communication across cultures. With this, the integrated competencies in foreign languages and intercultural communication are considered to be keys to successfully engaging and participating in modern life and society. The field of foreign language education is seen as a fundamental building block in fostering intercultural communicative competence (ICC). The dual focussed nature of CLIL-classrooms, i.e. the merging of a foreign language with content subject matter, seems to provide an ideal environment to initiate intercultural learning: content is never culturally neutral. Analysing, (re)constructing, comparing, contrasting and relativising one’s own cultural perspective and foreign cultural perspectives are essential elements in the development of intercultural competence. The ability to then shift and mediate between these cultural perspectives is a core objective in the intercultural learning process. Within rich CLIL environments a multitude of impulses may arise, which in turn lead to an exploration of different cultural viewpoints and, subsequently, enable shifts between these.
Finding Lost Features in Cloned Systems

Copying and adapting a system, also known as clone-and-own, is a common reuse approach that requires little initial effort. However, the drawbacks of clones are increasing maintenance costs as bug fixes and updates must be propagated. To reduce these costs, migrating cloned legacy systems towards a software product line promises to enable systematic reuse and customization. For both, managing and migrating cloned systems, it remains a challenge to identify and map features in the systems. In this paper, we i) propose a semi-automatic process to identify and map features between legacy systems, ii) suggest a corresponding visualization approach, and iii) assess our process on a case study. The results indicate that our process is suitable to identify features and present commonalities and variability in cloned systems. Our process can be used to enable traceability, prepare refactorings, and extract software product lines.
Extraversion and Behavioral Activation: Integrating the Components of Approach

This investigation evaluates the structure and correlates of lower order traits related to approach, specifically, facets of extraversion and behavioral activation system (BAS) sensitivity. A 3-factor structure of approach was derived in community and clinical samples: assertiveness, enthusiasm, and sensation seeking. All factors were positively associated with Openness/Intellect scores. Enthusiasm and assertiveness were both negatively associated with Neuroticism scores, but were distinguished by associations with Agreeableness and Conscientiousness. Sensation seeking was negatively associated with Conscientiousness scores. The 3 factors demonstrated a unique profile of association with components of impulsivity. Enthusiasm and assertiveness were negatively related to psychopathological symptoms, whereas sensation seeking was largely independent of psychopathology. Results suggest that approach is associated with 3 subfactors, which differ in their pattern or magnitude of associations with other variables, thus underscoring the importance of distinguishing among them. Further, results support the construct validity of the Assertiveness and Enthusiasm aspect scales of the Big Five Aspect Scales to assess traits at this level of the personality hierarchy.
Obesity Determines the Immunophenotypic Profile and Functional Characteristics of Human Mesenchymal Stem Cells From Adipose Tissue

Adipose tissue is a major source of mesenchymal stem cells (MSCs), which possess a variety of properties that make them ideal candidates for regenerative and immunomodulatory therapies. Here, we compared the immunophenotypic profile of human adipose‐derived stem cells (hASCs) from lean and obese individuals, and explored its relationship with the apparent altered plasticity of hASCs. We also hypothesized that persistent hypoxia treatment of cultured hASCs may be necessary but not sufficient to drive significant changes in mature adipocytes. hASCs were obtained from subcutaneous adipose tissue of healthy, adult, female donors undergoing abdominal plastic surgery: lean (n = 8; body mass index [BMI]: 23 ± 1 kg/m2) and obese (n = 8; BMI: 35 ± 5 kg/m2). Cell surface marker expression, proliferation and migration capacity, and adipogenic differentiation potential of cultured hASCs at two different oxygen conditions were studied. Compared with lean‐derived hASCs, obese‐derived hASCs demonstrated increased proliferation and migration capacity but decreased lipid droplet accumulation, correlating with a higher expression of human leukocyte antigen (HLA)‐II and cluster of differentiation (CD) 106 and lower expression of CD29. Of interest, adipogenic differentiation modified CD106, CD49b, HLA‐ABC surface protein expression, which was dependent on the donor's BMI. Additionally, low oxygen tension increased proliferation and migration of lean but not obese hASCs, which correlated with an altered CD36 and CD49b immunophenotypic profile. In summary, the differences observed in proliferation, migration, and differentiation capacity in obese hASCs occurred in parallel with changes in cell surface markers, both under basal conditions and during differentiation. Therefore, obesity is an important determinant of stem cell function independent of oxygen tension.