Miracle-dz/UniFAR-FTUs huggingface dataset:
[Seroprevalence of hepatitis A and cost evaluation of different vaccination strategies against hepatitis A virus in patients with chronic hepatitis C in France].

OBJECTIVES To prospectively determine the prevalence of total hepatitis virus A antibodies in patients with chronic hepatitis C and to evaluate the direct costs of several vaccination strategies against hepatitis A virus in these patients. METHODS From April 1 to July the 31 1998, 219 patients with hepatitis C virus antibodies underwent a systematic testing for total hepatitis virus A antibodies (MEIA-AXSYM, Abbott laboratories). The prevalence of hepatitis A virus antibodies was evaluated according to age and suspected way of hepatitis C contamination. This prevalence has been compared to that in individuals undergoing a check-up provided by the national health insurance system stratified by age. Direct costs of 2 vaccination strategies "A" and "B" were evaluated according to age (<40 vs > 40 years) and number of vaccine doses (1 or 2). "A" strategy included the systematic vaccination of all patients without determining the presence of total hepatitis A antibodies. "B" strategy included testing for total hepatitis A antibodies and vaccination of seronegative patients. The costs of these two strategies (A and B) were calculated with one and two vaccine doses. RESULTS The prevalence of total hepatitis A antibodies was 76% in the entire population. It increased after the age of 35 and was statistically higher in patients who were older than 40 than in patients younger than 40. This prevalence was not significantly different from that in individuals who underwent a check-up provided by the national health insurance system stratified according to age. "B" strategy with 2 vaccine doses was less expensive that A strategy in the whole population and in patients younger than 40. This strategy was less expensive with 1 vaccine dose except in patients who had recently screened positive for hepatitis C antibodies younger than 40 when it induced an increased in direct cost due to the low prevalence of total hepatitis A antibodies in these patients. CONCLUSIONS In patients with hepatitis C antibodies with a high prevalence of total hepatitis A antibodies, testing for the prevalence of these antibodies before vaccination decreases the direct cost of this vaccination.
Gender Differences in Sexual Health Knowledge Among Emerging Adults in Acute-Care Settings

Abstract Context Emerging adults (aged 18-25 years) are increasingly seeking evaluation in acute-care clinics for sexual health–related concerns to receive treatment and education. Objective To assess the sexual health knowledge of emerging adult patients by gender at acute-care health centers. Methods A prospective, self-administered survey was distributed from August 2014 through May 2016 to patients aged 18 to 24 years who presented to 1 of 4 acute-care locations in a university town in a mid-Atlantic state. Analyses included descriptive statistics, as well as χ2 and Fisher exact test crosstabulations to determine differences between genders. Results A total of 388 patients aged 18 to 24 years responded to the survey, with 81% of the sample identifying themselves as students and 64% identifying as female. Women were more likely than men to state that they sought sexual health advice at an urgent-care or walk-in clinic (70.3% vs 52.1%; P<.05). Human papillomavirus knowledge among women was significantly greater than among men (P<.0001). Open-ended responses were widespread and often incorrect, specifically with regard to the human papillomavirus vaccine and routine testing for sexually transmitted infections. Conclusion Women were more knowledgeable about sexual health than men. However, both genders were not as knowledgeable overall on sexual health topics as hypothesized. A stronger emphasis on gender-specific programming for sexual health education via community- and school-based programs throughout adolescence, supplemented with greater emphasis on routine preventive health care during adolescence and emerging adulthood, is encouraged.
Scalable Quantum Simulation of Molecular Energies

We report the first electronic structure calculation performed on a quantum computer without exponentially costly precompilation. We use a programmable array of superconducting qubits to compute the energy surface of molecular hydrogen using two distinct quantum algorithms. First, we experimentally execute the unitary coupled cluster method using the variational quantum eigensolver. Our efficient implementation predicts the correct dissociation energy to within chemical accuracy of the numerically exact result. Second, we experimentally demonstrate the canonical quantum algorithm for chemistry, which consists of Trotterization and quantum phase estimation. We compare the experimental performance of these approaches to show clear evidence that the variational quantum eigensolver is robust to certain errors. This error tolerance inspires hope that variational quantum simulations of classically intractable molecules may be viable in the near future.
Microglia responses to interleukin‐6 and type I interferons in neuroinflammatory disease

Microglia are the resident macrophages of the central nervous system (CNS). They are a heterogenous, exquisitely responsive, and highly plastic cell population, which enables them to perform diverse roles. They sense and respond to the local production of many different signals, including an assorted range of cytokines. Microglia respond strongly to interleukin‐6 (IL‐6) and members of the type I interferon (IFN‐I) family, IFN‐alpha (IFN‐α), and IFN‐beta (IFN‐β). Although these cytokines are essential in maintaining homeostasis and for activating and regulating immune responses, their chronic production has been linked to the development of distinct human neurological diseases, termed “cerebral cytokinopathies. ” IL‐6 and IFN‐α have been identified as key mediators in the pathogenesis of neuroinflammatory disorders including neuromyelitis optica and Aicardi‐Goutières syndrome, respectively, whereas IFN‐β has an emerging role as a causal factor in age‐associated cognitive decline. One of the key features that unites these diseases is the presence of highly reactive microglia. The current understanding is that microglia contribute to the development of cerebral cytokinopathies and represent an important therapeutic target. However, it remains to be resolved whether microglia have beneficial or detrimental effects. Here we review and discuss what is currently known about the microglial response to IL‐6 and IFN‐I, based on both animal models and clinical studies. Foundational knowledge regarding the microglial response to IL‐6 and IFN‐I is now being used to devise therapeutic strategies to ameliorate neuroinflammation and promote repair: either through targeting microglia, or by targeting the reduction of CNS levels or downstream biological pathways of IL‐6 or IFN‐I.
Acetate Causes Alcohol Hangover Headache in Rats

Background The mechanism of veisalgia cephalgia or hangover headache is unknown. Despite a lack of mechanistic studies, there are a number of theories positing congeners, dehydration, or the ethanol metabolite acetaldehyde as causes of hangover headache. Methods We used a chronic headache model to examine how pure ethanol produces increased sensitivity for nociceptive behaviors in normally hydrated rats. Results Ethanol initially decreased sensitivity to mechanical stimuli on the face (analgesia), followed 4 to 6 hours later by inflammatory pain. Inhibiting alcohol dehydrogenase extended the analgesia whereas inhibiting aldehyde dehydrogenase decreased analgesia. Neither treatment had nociceptive effects. Direct administration of acetate increased nociceptive behaviors suggesting that acetate, not acetaldehyde, accumulation results in hangover-like hypersensitivity in our model. Since adenosine accumulation is a result of acetate formation, we administered an adenosine antagonist that blocked hypersensitivity. Discussion Our study shows that acetate contributes to hangover headache. These findings provide insight into the mechanism of hangover headache and the mechanism of headache induction.
Daily Patterns of Marijuana and Alcohol Co‐Use Among Individuals with Alcohol and Cannabis Use Disorders

BACKGROUND The study aims were to examine daily associations between marijuana and alcohol use and the extent to which the association differs as a function of cannabis use disorder (CUD) and/or alcohol use disorder (AUD) diagnosis. METHODS Timeline Followback interview data was collected in a study of veterans (N = 127) recruited from a Veterans Affairs hospital who reported at least 1 day of co-use of marijuana and alcohol in the past 180 days (22,860 observations). Participants reported 40% marijuana use days, 28% drinking days, with 37% meeting DSM-5 criteria for CUD, 40% for AUD, and 15% for both. Use of marijuana on a given day was used to predict a 3-level gender-adjusted drinking variable (heavy: ≥5 (men)/4 (women) drinks; moderate: 1 to 4/3 drinks; or none: 0 drinks). A categorical 4-level variable (no diagnosis, AUD, CUD, or both) was tested as a moderator of the marijuana-alcohol relationship. RESULTS Multilevel modeling analyses demonstrated that participants were more likely to drink heavily compared to moderately (OR = 2.34) and moderately compared to not drinking (OR = 1.61) on marijuana use days relative to nonuse days. On marijuana use days, those with AUD and those with AUD + CUD were more likely to drink heavily (OR = 1.91; OR = 2.51, respectively), but those with CUD were less likely to drink heavily (OR = 0.32) compared to moderately, nonsignificant differences between any versus moderate drinking in interaction models. CONCLUSIONS Heavy drinking occurs on days when marijuana is also used. This association is particularly evident in individuals diagnosed with both AUD and CUD and AUDs alone but not in those with only CUDs. Findings suggest that alcohol interventions may need to specifically address marijuana use as a risk factor for heavy drinking and AUD.
Implementation of hospital wide dysphagia screening in a large acute tertiary teaching hospital

Abstract Purpose: There are no examples in the literature of successful long-term hospital-wide implementation of nurse-led dysphagia screening. This article aims to describe strategies used to implement hospital-wide dysphagia screening in a large acute tertiary teaching hospital in Australia. It reports on compliance, accuracy and nursing staff satisfaction using the validated Royal Brisbane and Women’s Hospital Dysphagia Screening Tool (RBWH DST). Method: A retrospective observational study of audit data was conducted to examine hospital-wide compliance and accuracy of dysphagia screen completion. A nursing staff survey measured staff satisfaction. Implementation included: (1) utilisation of validated tool (RBWH DST); (2) key stakeholder engagement and strong governance; (3) policy development; (4) education; and (5) review and monitoring processes. Result: Audits conducted over a 9-year period (n = 3726) showed an average hospital-wide compliance rate of 74% and an accuracy rate of 82%. A nurse satisfaction survey (n = 109) showed high levels of satisfaction associated with using the RBWH DST. Conclusion: The RBWH DST was implemented in a large acute tertiary teaching hospital with acceptable compliance and accuracy rates and favourable nursing staff satisfaction. Further study is required to objectively evaluate patient health and cost benefits associated with using the RBWH DST.
Offer Retrieving Strategies on a Commercial Web Site - An Exploratory Research

After presenting the concept of offer retrieving on the Internet, the present paper explore via a qualitative study the different strategies used by the consumer to retrieve a product on a commercial web site and the role of familiarity in the determination of such strategy. Our results show that individual ability to retrieve the offer on a commercial Web site would depend on the adopted strategy and on the Internet familiarity level. Confirming the idea according to which there is a narrow link between the usability and offer accessibility on an e-commerce site.
What makes children with cerebral palsy vulnerable to malnutrition? Findings from the Bangladesh cerebral palsy register (BCPR)

Abstract Purpose: To assess the nutritional status and underlying risk factors for malnutrition among children with cerebral palsy in rural Bangladesh. Materials and methods: We used data from the Bangladesh Cerebral Palsy Register; a prospective population based surveillance of children with cerebral palsy aged 0–18 years in a rural subdistrict of Bangladesh (i.e., Shahjadpur). Socio-demographic, clinical and anthropometric measurements were collected using Bangladesh Cerebral Palsy Register record form. Z scores were calculated using World Health Organization Anthro and World Health Organization AnthroPlus software. Results: A total of 726 children with cerebral palsy were registered into the Bangladesh Cerebral Palsy Register (mean age 7.6 years, standard deviation 4.5, 38.1% female) between January 2015 and December 2016. More than two-third of children were underweight (70.0%) and stunted (73.1%). Mean z score for weight for age, height for age and weight for height were −2.8 (standard deviation 1.8), −3.1 (standard deviation 2.2) and −1.2 (standard deviation 2.3) respectively. Moderate to severe undernutrition (i.e., both underweight and stunting) were significantly associated with age, monthly family income, gross motor functional classification system and neurological type of cerebral palsy. Conclusions: The burden of undernutrition is high among children with cerebral palsy in rural Bangladesh which is augmented by both poverty and clinical severity. Enhancing clinical nutritional services for children with cerebral palsy should be a public health priority in Bangladesh. Implications for Rehabilitation Population-based surveillance data on nutritional status of children with cerebral palsy in Bangladesh indicates substantially high burden of malnutrition among children with CP in rural Bangladesh. Children with severe form of cerebral palsy, for example, higher Gross Motor Function Classification System (GMFCS) level, tri/quadriplegic cerebral palsy presents the highest proportion of severe malnutrition; hence, these vulnerable groups should be focused in designing nutrition intervention and rehabilitation programs. Disability inclusive and focused nutrition intervention programme need to be kept as priority in national nutrition policies and nutrition action plans specially in low- and middle-income countries. Community-based management of malnutrition has the potential to overcome this poor nutritional scenario of children with disability (i.e., cerebral palsy). The global leaders such as World Health Organization, national and international organizations should take this in account and conduct further research to develop nutritional guidelines for this vulnerable group of population.
Multiparameter flow cytometry applications in the diagnosis of mixed phenotype acute leukemia

Mixed phenotype acute leukemias (MPALs) represent a rare subgroup of acute leukemias with a poor prognosis. Proper diagnosis and classification of MPAL is extremely important for patients' outcome. Morphology and flow cytometry recognize two types of MPAL: the “bilineal” MPAL with the coexistence of two blast populations of different lineage and truly “biphenotypic” MPAL coexpressing markers of more than one lineage in a homogenous blast population, respectively. The WHO 2008 classification further delineated three categories: associated with t(9;22)/BCR‐ABL1 fusion gene, associated with KMT2A (mixed lineage leukemia) rearrangements, and nonotherwise specified. These categories remained unchanged in the WHO2016 update. Molecular studies have further underlined the heterogeneity of MPAL. In this review, rules for the correct assignment of acute leukemia to the MPAL category are discussed, including both flow cytometry and immunohistochemistry on bone marrow or other tissues biopsies. Comparison of the immunophenotypic classification proposals is provided outlining the explorations mandatory for definitive diagnosis. An extensive review of published data summarizes the reported cytogenetic and molecular anomalies. New developments in the understanding of the early stages of hematopoiesis provide clues to the possible etiopathology of these diseases. Finally, current treatment recommendations are summarized and referenced for clinical use, pointing out that allogeneic hematopoietic stem cell transplantation at an early stage should be considered (at least in adult patients). © 2019 International Clinical Cytometry Society
Cognition in adults with Williams syndrome—A 20‐year follow‐up study

Williams syndrome (WBS) is a genetic multisystem disorder. The main symptom is borderline (intelligence quotient, IQ 70–79) or abnormally low intelligence (IQ < 70). According to earlier studies young individuals with WBS demonstrate generally a slightly higher verbal IQ (VIQ) compared to performance/nonverbal IQ (PIQ). WBS was recognized as a distinct entity already about 60 years ago, but still cognition in adults with WBS is poorly known.
IRONHIDE: A Secure Multicore Architecture that Leverages Hardware Isolation Against Microarchitecture State Attacks

Modern microprocessors enable aggressive hardware virtualization that exposes the microarchitecture state of the processor due to temporal sharing of hardware resources. This paper proposes a novel secure multicore architecture, IRONHIDE that aims to mitigate both speculative and non-speculative microarchitecture state vulnerabilities. It introduces novel spatial allocation of hardware resources across two concurrent domains, i.e., a secure and an insecure application domain (referred to as clusters of cores). IRONHIDE enables strong isolation by disallowing sharing of any hardware structures across cluster boundaries to mitigate microarchitecture state attacks. To tackle speculative microarchitecture state vulnerabilities, this work introduces a novel insight that all speculative microarchitecture state exploits rely on a victim application to access secure cluster's memory regions. Thus, IRONHIDE incorporates a lightweight hardware check that detects such accesses, and stall them until they resolve. This mitigates potential speculative microarchitecture state attacks. Lastly, IRONHIDE enables dynamic hardware isolation by reallocating core-level resources across clusters to exploit multicore parallelism, while ensuring strong isolation for dynamically allocated resources.
Neutron skins of atomic nuclei: per aspera ad astra

The complex nature of the nuclear forces generates a broad range and diversity of observational phenomena. Heavy nuclei, though orders of magnitude less massive than neutron stars, are governed by the same underlying physics, which is enshrined in the nuclear equation of state. Heavy nuclei are expected to develop a neutron-rich skin where many neutrons collect near the surface. Such a skin thickness is strongly sensitive to the poorly-known density dependence of the symmetry energy near saturation density. An accurate and model-independent determination of the neutron-skin thickness of heavy nuclei would provide a significant first constraint on the density dependence of the nuclear symmetry energy. The determination of the neutron-skin thickness of heavy nuclei has far reaching consequences in many areas of physics as diverse as heavy-ion collisions, polarized electron and proton scattering off nuclei, precision tests of the standard model using atomic parity violation, and nuclear astrophysics. While a systematic and concerted experimental effort has been made to measure the neutron-skin thickness of heavy nuclei, a precise and model-independent determination remains elusive. How to move forward at a time when many new facilities are being commissioned and how to strengthen the synergy with other areas of physics are primary goals of this review.
The Origin of [C ii] 158 μm Emission toward the H ii Region Complex S235

Although the transition of [C ii] at λ ≃ 158 is known to be an excellent tracer of active star formation, we still do not have a complete understanding of where within star formation regions the emission originates. Here, we use SOFIA upGREAT observations of [C ii] emission toward the H ii region complex Sh2-235 (S235) to better understand in detail the origin of [C ii] emission. We complement these data with a fully sampled Green Bank Telescope radio recombination line map tracing the ionized hydrogen gas. About half of the total [C ii] emission associated with S235 is spatially coincident with ionized hydrogen gas, although spectroscopic analysis shows little evidence that this emission is coming from the ionized hydrogen volume. Velocity-integrated [C ii] intensity is strongly correlated with Wide-field Infrared Survey Explorer (WISE) 12 intensity across the entire complex, indicating that both trace ultraviolet radiation fields. The 22 and radio continuum intensities are only correlated with [C ii] intensity in the ionized hydrogen portion of the S235 region and the correlations between the [C ii] and molecular gas tracers are poor across the region. We find similar results for emission averaged over a sample of external galaxies, although the strength of the correlations is weaker. Therefore, although many tracers are correlated with the strength of [C ii] emission, only WISE 12 emission is correlated on small scales of the individual H ii region S235 and also has a decent correlation at the scale of entire range of galaxies. Future studies of a larger sample of Galactic H ii regions would help to determine whether these results are truly representative.
Massive Young Stellar Objects and Outflow in the Infrared Dark Cloud G79.3+0.3

G79.3+0.3 is an infrared dark cloud in the Cygnus-X complex that is home to massive deeply embedded young stellar objects (YSOs). We have produced a Submillimeter Array (SMA) 1.3 mm continuum image and 12CO line maps of the eastern section of G79.3+0.3 in which we detect five separate YSOs. We have estimated physical parameters for these five YSOs and others in the vicinity of G79.3+0.3 by fitting existing photometry from Spitzer, Herschel, and ground-based telescopes to spectral energy distribution models. Through these model fits we find that the most massive YSOs seen in the SMA 1.3 mm continuum emission have masses in the 5–6 M☉ range. One of the SMA sources was observed to power a massive collimated 12CO outflow extending at least 0.94 pc in both directions from the protostar, with a total mass of 0.83 M☉ and a dynamical timescale of 23 kyr.
Region homogeneity in the Logarithmic Image Processing framework: application to region growing algorithms

In order to create an image segmentation method robust to lighting changes, two novel homogeneity criteria of an image region were studied. Both were defined using the Logarithmic Image Processing (LIP) framework whose laws model lighting changes. The first criterion estimates the LIP-additive homogeneity and is based on the LIP-additive law. It is theoretically insensitive to lighting changes caused by variations of the camera exposure-time or source intensity. The second, the LIP-multiplicative homogeneity criterion, is based on the LIP-multiplicative law and is insensitive to changes due to variations of the object thickness or opacity. Each criterion is then applied in Revol and Jourlin’s (1997) region growing method which is based on the homogeneity of an image region. The region growing method becomes therefore robust to the lighting changes specific to each criterion. Experiments on simulated and on real images presenting lighting variations prove the robustness of the criteria to those variations. Compared to a state-of the art method based on the image component-tree, ours is more robust. These results open the way to numerous applications where the lighting is uncontrolled or partially controlled.