Miracle-dz/UniFAR-FTUs huggingface dataset:
Rituais e símbolos na atenção formal à saúde: o caso do vestuário profissional, na ótica de pacientes da Atenção Básica

Este trabalho teve como objetivo analisar e interpretar as reflexoes e experiencias de usuarios frequentadores do servico de Atencao Primaria a Saude / Unidades de Saude da Familia (USF) sobre o uso do jaleco branco ou roupas brancas por medicos e outros profissionais de saude. O metodo utilizado foi o de entrevistas individuais com questoes abertas, em profundidade, com usuarios de USF, transcritas integralmente e analisadas quanto ao conteudo e enunciados. A amostra foi fechada por saturacao teorica. Como resultado, identificou-se nas 11 entrevistas uma marcante assimetria sociocultural e psicologica como pano de fundo dos tres nucleos de sentido identificados: vestuario como marca identitaria; vestuario nao valorizado como simbolo de competencia profissional e vestuario interferindo, positiva ou negativamente, nas relacoes entre clinicos e pacientes. Discutem-se a premencia a simbolizacao na area da saude, as dificuldades dos participantes em discorrer sobre o tema e sobre o porque da emergencia de possiveis novos simbolos de competencia. Finalmente, concluiu-se que compreender os significados atribuidos pelos usuarios dos sistemas de saude aos atos e praticas realizados por seus cuidadores pode contribuir para o aperfeicoamento progressivo dessas praticas formais de cuidado. Embora as funcoes ritualisticas dos comportamentos e objetos utilizados nos atos de cuidado a saude sejam mais facilmente observadas nas chamadas praticas informais e populares, elas persistem nas maneiras formais ou profissionais de agir. Esse tipo de fenomeno se deu apos a emergencia da medicina cientifica moderna, com o jaleco branco, por exemplo, e ainda se da, na atualidade, embora novos simbolos parecam surgir e ocupar esse espaco ritualistico.
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice

Liver kinase B1 (LKB1; also known as STK11) is a serine/threonine kinase and tumour suppressor that is mutated in Peutz-Jeghers syndrome (PJS), a premalignant syndrome associated with the development of gastrointestinal polyps. Proglucagon-expressing enteroendocrine cells are involved in the control of glucose homeostasis and the regulation of appetite through the secretion of gut hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine tyrosine (PYY). To determine the role of LKB1 in these cells, we bred mice bearing floxed alleles of Lkb1 against animals carrying Cre recombinase under proglucagon promoter control. These mice (GluLKB1KO) were viable and displayed near-normal growth rates and glucose homeostasis. However, they developed large polyps at the gastro-duodenal junction, and displayed premature mortality (death from 120 days of age). Histological analysis of the polyps demonstrated that they had a PJS-like appearance with an arborising smooth-muscle core. Circulating GLP-1 levels were normal in GluLKB1KO mice and the polyps expressed low levels of the peptide, similar to levels in the neighbouring duodenum. Lineage tracing using a Rosa26tdRFP transgene revealed, unexpectedly, that enterocytes within the polyps were derived from non-proglucagon-expressing precursors, whereas connective tissue was largely derived from proglucagon-expressing precursors. Developmental studies in wild-type mice suggested that a subpopulation of proglucagon-expressing cells undergo epithelial-mesenchymal transition (EMT) to become smooth-muscle-like cells. Thus, it is likely that polyps in the GluLKB1KO mice developed from a unique population of smooth-muscle-like cells derived from a proglucagon-expressing precursor. The loss of LKB1 within this subpopulation seems to be sufficient to drive tumorigenesis.
Lumbar spinal loading during bowling in cricket: a kinetic analysis using a musculoskeletal modelling approach

ABSTRACT The objective of the study was to evaluate two types of cricket bowling techniques by comparing the lumbar spinal loading using a musculoskeletal modelling approach. Three-dimensional kinematic data were recorded by a Vicon motion capture system under two cricket bowling conditions: (1) participants bowled at their absolute maximal speeds (max condition), and (2) participants bowled at their absolute maximal speeds while simultaneously forcing their navel down towards their thighs starting just prior to ball release (max-trunk condition). A three-dimensional musculoskeletal model comprised of the pelvis, sacrum, lumbar vertebrae and torso segments, which enabled the motion of the individual lumbar vertebrae in the sagittal, frontal and coronal planes to be actuated by 210 muscle-tendon units, was used to simulate spinal loading based on the recorded kinematic data. The maximal lumbar spine compressive force is 4.89 ± 0.88BW for the max condition and 4.58 ± 0.54BW for the max-trunk condition. Results showed that there was no significant difference between the two techniques in trunk moments and lumbar spine forces. This indicates that the max-trunk technique may not increase lower back injury risks. The method proposed in this study could be served as a tool to evaluate lower back injury risks for cricket bowling as well as other throwing activities.
Left atrioventricular plane displacement but not left ventricular ejection fraction is influenced by the degree of aortic stenosis

Aims: To examine how left atrioventricular plane displacement (AVPD), a widely used measure of left ventricular (LV) function, is related to presence and degree of aortic stenosis. Methods and results: Cardiac dimensions, LV filling, left AVPD, LV ejection fraction (LVEF), and valve function were assessed by echocardiography/Doppler in 182 patients with various cardiac diseases (mean (SD) age 69 (12) years, 36% women), 49 consecutive with and 133 consecutive without aortic stenosis. In an analysis of covariance, neither left AVPD nor LVEF was independently correlated with the presence of aortic stenosis. However, looking separately at patients with aortic stenosis, left AVPD (p = 0.03) but not LVEF correlated independently with degree of aortic stenosis in multiple linear regression analysis. In patients with aortic stenosis, an abnormal left AVPD had 94% sensitivity and 90% negative predictive value with regard to severe aortic stenosis, compared with 56% and 62%, respectively, for LVEF. Conclusion: In patients with cardiac disease, neither left AVPD nor LVEF correlated independently with presence of aortic stenosis. However, in patients with aortic stenosis, left AVPD but not LVEF correlated with the degree of aortic valve obstruction and left AVPD but not LVEF had high sensitivity and negative predictive value with regard to severe aortic stenosis. Compared with LVEF, left AVPD is an earlier and more sensitive marker of LV haemodynamic load in patients with aortic stenosis.
Quality of Life as a Conceptual Framework for Evaluating Transition Outcomes

When the transition movement began as a federal initiative in 1984, it was conceptualized as “an outcome-oriented process leading to employment. ” Although many educators viewed this narrow focus on employment as too constrictive, an alternative framework for conceptualizing transition outcomes has been slow to develop. This article explores a broader framework, quality of life, organized around three topics: (1) theoretical issues that pertain to the definition and conceptualization of quality of life; (2) research findings that provide support for quality of life as an outcome framework for evaluating transition programs and services; and (3) a few suggestions about issues we should address as we move through the 1990s.
Localization of an Ascorbate-Reducible Cytochrome b561 in the Plant Tonoplast12

As a free radical scavenger, and cofactor, ascorbate (ASC) is a key player in the regulation of cellular redox processes. It is involved in responses to biotic and abiotic stresses and in the control of enzyme activities and metabolic reactions. Cytochromes (Cyts) b561 catalyze ASC-driven trans-membrane electron transport and contribute to ASC-mediated redox reactions in subcellular compartments. Putative Cyts b561 have been identified in Arabidopsis (ecotype Columbia) on the basis of sequence similarity to their mammalian counterparts. However, little is known about the function or subcellular localization of this unique class of membrane proteins. We have expressed one of the putative Arabidopsis Cyt b561 genes (CYBASC1) in yeast and we demonstrate that this protein encodes an ASC-reducible b-type Cyt with absorbance characteristics similar to that of other members of this family. Several lines of independent evidence demonstrate that CYBASC1 is localized at the plant tonoplast (TO). Isoform-specific antibodies against CYBASC1 indicate that this protein cosediments with the TO marker on sucrose gradients. Moreover, CYBASC1 is strongly enriched in TO-enriched membrane fractions, and TO fractions contain an ASC-reducible b-type Cyt with α-band absorbance maximum near 561 nm. The TO ASC-reducible Cyt has a high specific activity, suggesting that it is a major constituent of this membrane. These results provide evidence for the presence of trans-membrane redox components in this membrane type, and they suggest the coupling of cytoplasmic and vacuolar metabolic reactions through ASC-mediated redox activity.
A Critical Period for Activity-Dependent Synaptic Development during Olfactory Bulb Adult Neurogenesis

New neurons integrate in large numbers into the mature olfactory bulb circuit throughout life. The factors controlling the synaptic development of adult-born neurons and their connectivity remain essentially unknown. We examined the role of activity-dependent mechanisms in the synaptic development of adult-born neurons by genetic labeling of synapses while manipulating sensory input or cell-intrinsic excitability. Sensory deprivation induced marked changes in the density of input and output synapses during the period when new neurons develop most of their synapses. In contrast, when sensory deprivation started after synaptic formation was complete, input synapses increased in one domain without detectable changes in the other dendritic domains. We then investigated the effects of genetically raising the intrinsic excitability of new neurons on their synaptic development by delivering a voltage-gated sodium channel that triggers long depolarizations. Surprisingly, genetically increasing excitability did not affect synaptic development but rescued the changes in glutamatergic input synapses caused by sensory deprivation. These experiments show that, during adult neurogenesis in the olfactory bulb, synaptic plasticity is primarily restricted to an early period during the maturation of new neurons when they are still forming synapses. The addition of cells endowed with such an initial short-lived flexibility and long-term stability may enable the processing of information by the olfactory bulb to be both versatile and reliable in the face of changing behavioral demands.
System of singular second-order differential equations with integral condition on the positive half-line

In this work, we are concerned with the existence and the multiplicity of nontrivial positive solutions for a boundary value problem of a system of second-order dierential equations subject to an integral boundary condition and posed on the positive half-line. The positive nonlinearities depend on the solution and their derivatives and may have space singularities. New existence results of single and multiple solutions are obtained by means of the xed point index theory on special cones in some weighted Banach space. Examples with numerical computations are included to illustrate the obtained existence theorems. This paper surveys and generalizes previous works.
Marginal Religious Affiliates in Canada: Little Reason to Expect Increased Church Involvement

Dans cette document, j'utilise les donnees des entrevues avec vingt et un filiales religieuse au Canada qui assistent aux offices religieux surtout pour des fetes religieuses et les rites de passage, en demandent pourquoi ils ont cesse de frequenter sur une base reguliere, pourquoi ils continuent a frequenter une ou deux fois par annee, et expriment-ils tout interet a etre plus impliques dans leur groupe religieux, et si oui, quels facteurs pourraient conduire a une implication accrue. Contrairement a Reginald Bibby, et d'autres sources qui expliquent les modeles d'implication aux eglises par insistant sur le cote de l'offre du marche religieux, je soutiens que nous devrions nous concentrer d'avantage sur le cote de la demande. In this paper, I draw on interview data with 21 Canadian marginal religious affiliates, who attend religious services primarily for religious holidays and rites of passage, and ask why they stopped attending on a regular basis, why they continue to attend once or twice a year, and do they express any interest in being more involved in their religious group, and if so, what factors might lead to increased involvement. In contrast to Reginald Bibby and others who explain church involvement patterns by stressing the supply side of the religious marketplace, I argue that we should concentrate more on the demand side.
High-Performance Pentacene Thin-Film Transistors Fabricated by Organic Vapor-Jet Printing

Organic vapor-jet printing, a maskless direct printing method, is used to fabricate high-performance pentacene thin-film transistors. By combining the optimal carrier gas temperature and the surface treatment of gate dielectrics, a mobility of 0.46 (±0.03) cm2 V-1 s-1 and an on-off ratio greater than 107 are achieved. Morphological analyses indicate that the relatively high carrier gas temperature and low surface energy of the dielectric surface are the keys in achieving the level of performance comparable to that of devices based on conventional technologies.
How much explanation is enough? A study of parent requests for information and physician responses.

OBJECTIVE To examine the relationship between doctor-parent communication patterns and parents' perceptions that they were listened to by the doctor. DESIGN Cross-sectional, clinic-based survey. Before the visit, parents were asked about the strength of their desires/preferences for being listened to; after the visit, they were asked if their desires were fulfilled and to rate their satisfaction with care. Encounters were audiotaped, transcribed, and coded for parent requests for information and action and physician responses to those requests. Coding was performed using an adapted version of the Taxonomy of Requests by Patients (TORP). Physician responses to parental requests for information were coded as brief, moderate, or prolonged fulfillment or as partially fulfilled, ignored, or denied. SETTING Two private pediatric practices, 1 community based and 1 university based. PARTICIPANTS Ten of 13 eligible physicians (participation rate, 77%) and 306 of 356 eligible parents (participation rate, 86%) who sought care for their children's respiratory illnesses. Parents were invited to participate if they spoke and read English and if their child was 2-10 years old, had a chief complaint of cold symptoms, and was seeing one of the participating physicians. Complete data were obtained for 287 doctor-parent encounters (94%). RESULTS Before the visit, 74% of parents reported that they considered it necessary for the physician to listen to their ideas about their child's illness. Among these parents, 62% (n = 130) reported after the visit that the physician had listened to their ideas. As the proportion of moderate-length responses to parent requests for information increased, parents were significantly more likely to report being listened to (P <.05). Multivariate results indicated a 59% probability of parents reporting that they were listened to when given moderate-length responses, 45% when given brief responses, 39% when given prolonged responses, and 12% when requests for information were only partially fulfilled, ignored, or denied. The length of response to parent requests for information was not related to overall parent satisfaction. CONCLUSIONS Parents who received moderate-length answers to their questions were most likely to report that they were listened to. Although it is assumed that lengthier, in-depth explanations result in higher satisfaction, this study suggests that more doctor talk does not necessarily constitute better communication.
SH-SAW biosensor on quartz

This paper describes a shear horizontal surface acoustic wave (SH-SAW) immunoassay biosensor on a quartz substrate. The SH-SAW biosensor is a 250MHz SH-SAW delay-line which has a gold surface covered with antibodies. It is important to discuss the detection mechanism of SH-SAW biosensors on quartz. In this paper, the detection mechanism of SH-SAW biosensors are investigated, using three methods of numerical analysis. The first method is a mass loading model analysis. The second method is a viscosity model analysis. The third method is a viscoelasticity model analyasis. A numerical calculation method for SH-SAW propagation characteristics, which is a modified Campbell and Jones method involving the effect of liquid viscosity is applied to quartz. In order to confirm the proposed numerical analysis models, 250MHz SH-SAW biosensors on quartz substrates were tested. The mass, viscosity, and viscoelastic behavior of fluids on SH-SAW biosensors were theoretically and experimentally discussed.
Insights from Characterizing Extinct Human Gut Microbiomes

In an effort to better understand the ancestral state of the human distal gut microbiome, we examine feces retrieved from archaeological contexts (coprolites). To accomplish this, we pyrosequenced the 16S rDNA V3 region from duplicate coprolite samples recovered from three archaeological sites, each representing a different depositional environment: Hinds Cave (∼8000 years B.P.) in the southern United States, Caserones (1600 years B.P.) in northern Chile, and Rio Zape in northern Mexico (1400 years B.P.). Clustering algorithms grouped samples from the same site. Phyletic representation was more similar within sites than between them. A Bayesian approach to source-tracking was used to compare the coprolite data to published data from known sources that include, soil, compost, human gut from rural African children, human gut, oral and skin from US cosmopolitan adults and non-human primate gut. The data from the Hinds Cave samples largely represented unknown sources. The Caserones samples, retrieved directly from natural mummies, matched compost in high proportion. A substantial and robust proportion of Rio Zape data was predicted to match the gut microbiome found in traditional rural communities, with more minor matches to other sources. One of the Rio Zape samples had taxonomic representation consistent with a child. To provide an idealized scenario for sample preservation, we also applied source tracking to previously published data for Ötzi the Iceman and a soldier frozen for 93 years on a glacier. Overall these studies reveal that human microbiome data has been preserved in some coprolites, and these preserved human microbiomes match more closely to those from the rural communities than to those from cosmopolitan communities. These results suggest that the modern cosmopolitan lifestyle resulted in a dramatic change to the human gut microbiome.
Entrepreneurial Failure, Networks and Sensemaking: An Interpretive Phenomenological Analysis

The purpose of this study is to advance the theoretical knowledge of how entrepreneurs who have experienced business failure make use of personal and professional relationships within their network during their sensemaking process. Six in-depth, semi-structured interviews were conducted with entrepreneurs who terminated their business in Sweden and Denmark. Their stories were analyzed through an Interpretative Phenomenological Analysis (IPA) with an aim to answer the following question: how do entrepreneurs who experience failure make use of different relationships within their network during their sensemaking process? The empirical findings present that the times in which participants reached out to members of their network can be split into two parts: during the failure and after the failure. In analyzing the emerging themes that came to light through the above analysis, there appear to be five factors (loss, identity, attitude towards failure, risk acknowledgement, previous experience) that are categorized into one superordinate theme (failure attribution), which seems to correlate with whether or not an entrepreneur actively engages in sensemaking following a failure. Lastly, theoretical and practical implications were delineated.
Inquiry, Engagement, and Literacy in Science: A Retrospective, Cross-National Analysis Using PISA 2006

In this study, we examine patterns of students’ literacy and engagement in science associated with different levels of “inquiry-oriented” learning reported by students in Australia, Canada, and New Zealand. To achieve this, we analyzed data from the Organisation for Economic Co-operation and Development's 2006 Programme for International Student Assessment, which had science as its focus. Consistently, our findings show that science students who report experiencing low levels of inquiry-oriented learning activities are found to have above-average levels of science literacy, but below-average levels of interest in science, and below-average levels on six variables that reflect students’ engagement in science. Our findings show that the corollary is also true. Across the three countries, students who report high levels of inquiry-oriented learning activities in science are observed to have below-average levels of science literacy, but above-average levels of interest in learning science, and above-average engagement in science. These findings appear to run counter to science education orthodoxy that the more students experience inquiry-oriented teaching and learning, the more likely they are to have stronger science literacy, as well as more positive affect toward science. We discuss the implications of these findings for science educators and researchers.
Neuropsychological Responses in COA’s

More than one-half of alcoholics may exhibit deficits in the processing of visual-spatial information, learning and memory, problem-solving and abstracting capabilities, and the regulation of goal-directed behavior. Research using nonalcoholic subjects suggests that some of these deficits may be familial and may predate the development of alcoholism. Results using alcoholic subjects are inconclusive, however, perhaps reflecting the effects of long-term alcohol consumption on cognitive performance. Factors that may influence the interpretation of results include psychiatric disorders, emotional instability, and type of alcoholism. Studies are needed to determine whether children from alcoholic families who become alcoholic themselves prove to be those who were previously most deficient in cognitive abilities.
AT 1 a receptor signaling is required for basal and water deprivation-induced urine concentration in AT 1 a receptor-deficient mice

Xiao C. Li, Yuan Shao, and Jia L. Zhuo Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi; Center of Excellence for Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Mississippi; and Division of Nephrology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, Mississippi