Miracle-dz/UniFAR-FTUs huggingface dataset:
Interfund lending in mutual fund families : Role in liquidity management 1

Although the 1940 Act restricts interfund lending within a mutual fund family, families can apply for regulatory exemptions to participate in interfund lending. We find that heterogeneity in portfolio liquidity and investor flows across funds, funds’ investment restrictions, and governance mechanisms influence the fund family’s decision to apply for interfund lending. We document several costs and benefits of interfund lending. Costs include lower sensitivity of managers’ turnover to past performance and greater investor withdrawal for poorly governed funds. Benefits include funds being able to hold more illiquid and concentrated portfolios, and being less susceptible to runs. JEL Classification: G18, G23, G32
Mining Interaction Behaviors for Email Reply Order Prediction

In email networks, user behaviors affect the way emails are sent and replied. While knowing these user behaviors can help to create more intelligent email services, there has not been much research into mining these behaviors. In this paper, we investigate user engagingness and responsiveness as two interaction behaviors that give us useful insights into how users email one another. Engaging users are those who can effectively solicit responses from other users. Responsive users are those who are willing to respond to other users. By modeling such behaviors, we are able to mine them and to identify engaging or responsive users. This paper proposes four types of models to quantify engagingness and responsiveness of users. These behaviors can be used as features in the email reply order prediction task which predicts the email reply order given an email pair. Our experiments show that engagingness and responsiveness behavior features are more useful than other non-behavior features in building a classifier for the email reply order prediction task. When combining behavior and non-behavior features, our classifier is also shown to predict the email reply order with good accuracy.
Primitive auditory stream segregation: a neurophysiological study in the songbird forebrain.

Auditory stream segregation refers to the perceptual grouping of sounds, to form coherent representations of objects in the acoustic scene, and is a fundamental aspect of hearing and speech perception. The perceptual segregation of simple interleaved tone sequences has been studied in humans and European starlings (Sturnus vulgaris) using sequences of 2 alternating tones differing in frequency (ABA-ABA-ABA-.). The segregation of A and B tones into separate auditory streams is believed to be promoted by preattentive auditory processes that increase the separation of excitation patterns along a tonotopic gradient. We tested the hypothesis that frequency selectivity and forward masking operate as 2 preattentive processes in sequential stream segregation by recording neural responses in the auditory forebrain of awake starlings to repeated ABA- sequences in which we varied the frequency separation (DeltaF) between the A and B tones and the tone repetition time (TRT). The A tones were presented at the neurons' characteristic frequency (CF), and B tones differed from the CF over a one-octave range. Larger DeltaF values and shorter TRTs promote the perceptual segregation of alternating tone sequences in humans and also resulted in larger differences in neural responses to alternating CF (A) and non-CF (B) tones. Our results are consistent with the hypothesis that preattentive auditory processes, such as frequency selectivity and forward masking, contribute to the perceptual segregation of sequential acoustic events having different frequencies into separate auditory streams, but also suggest that additional processes may be required to account for all known perceptual effects related to sequential auditory stream segregation.
Pegylated liposomal doxorubicin in combination with cyclophosphamide and trastuzumab in HER2-positive metastatic breast cancer patients: efficacy and cardiac safety from the GEICAM/2004-05 study.

BACKGROUND In order to determine the feasibility of substituting pegylated liposomal doxorubicin (PLD) for doxorubicin in combination with cyclophosphamide and trastuzumab as adjuvant therapy, we conducted a phase II study of the combination as first-line therapy in human epidermal growth factor receptor 2 (HER2) overexpressing metastatic breast cancer (MBC). METHODS PLD 50 mg/m(2) and cyclophosphamide 600 mg/m(2) were administered every 4 weeks for six cycles; trastuzumab (4 mg/kg loading dose, then 2 mg/kg) was administered weekly for 24 weeks. The primary end point was objective response rate (ORR), and the secondary end points included time to progression (TTP), overall survival (OS), and safety. RESULTS Among the 48 evaluable patients, ORR was 68.8% [95% confidence interval (CI) 55.69% to 81.91%], with 6 patients (12.5%) achieving a complete response and 27 (56.2%) a partial response. The median TTP was 12 months (95% CI 9-15.1 months), and the median OS was 34.2 months (95% CI 27.2-41.2 months). Febrile neutropenia was seen in three patients, grade 3 hand-foot syndrome in 29.2% of patients, and grade 3-4 mucositis in 22.9% of patients. Symptomatic congestive heart failure was not observed, and 16.7% of patients experienced grade 2 asymptomatic left ventricular systolic dysfunction. CONCLUSION The combination of PLD-cyclophosphamide-concurrent trastuzumab is a feasible, safe, and effective first-line regimen for HER2-overexpressing MBC.
Binding of nickel and zinc ions to bacitracin A.

Bacitracin A is a cyclic dodecapeptide antibiotic produced by Bacillus licheniformis. Bacteriocidal activity requires the presence of divalent cations such as Zn2+. The metal-bacitracin A complex binds to bactoprenyl pyrophosphate, a lipid intermediate required for cell wall biosynsthesis which is found within the bacterial membrane. In this paper, the pH dependence of the metal binding to bacitracin A is investigated in an effort to define the sites of metal coordination. Most of the studies described in this report were performed with Ni2+ and Zn2+. Metal binding was monitored by observing changes in the ultraviolet absorption spectrum of bacitracin A and by monitoring the proton release which is concomitant with metal binding to the peptide. It was determined that both Ni2+ and Zn2+ form 1:1 complexes with bacitracin A in solution. These complexes are soluble in acidic solutions, but above approximately pH 5.5 they become insoluble. On the basis of the data reported as well as results previously reported from other laboratories, a model for divalent metal ion binding to bacitracin is suggested. It is proposed that the metal coordinates directly to the glutamate carboxyl, the histidine imidazole, and the thiazoline ring. The aspartate carboxyl and N-terminal amino group are not directly involved in metal binding. It is further proposed that due to the proximity of the metab, the pK of the N-terminal amino is shifted from 7.7 to 5.7 upon metal binding. Deprotonation of this group is suggested to cause precipitation of the bacitracin A-metal complex. This model is consistent with all the metal binding data and, furthermore, is consistent with the 1H NMR data presented in the accompanying paper [Mosberg, H. I. , Scogin, D. A. , Storm, D. R. , & Gennis, R. B. (1980) Biochemistry (following paper in this issue)].
Fluencia verbal: estudio normativo piloto según estrategias de «agrupación» y «saltos» de palabras en población española de 20 a 49 años

Fluencia verbal: estudio normativo piloto segun estrategias de «agrupacion» y «saltos» de palabras en poblacion espanola de 20 a 49 anos Introduction. The aim of this study is to establish normative data on phonological and semantic verbal fluency tests, measuring total production of words, clusters and switching of words in a healthy young adult Spanish population. Material and methods. We assessed 53 healthy adults between 20-49 years old (32.8 ± 9.5) with 8-18 years of formal education (9 ± 3.3 years). The semantic fluency category included: animals, fruits, clothes and the initial letters F, A, S in 1 minute of time. Clustering and switching strategies were examined and scored according to a protocol elaborated ad hoc by the authors. Pearson correlations between number of «clusters», «switching» and total number of words was used and we evaluated the possible influence of age, years of schooling and gender in each one of the categories in 1 minute and in intervals of 15 seconds. Results. The variable years of formal education was the only demographical factor that significantly influenced semantic verbal fluency (r = 0.43; p = 0.04). Switching and clustering were positively correlated with the number of words generated. Clustering was highly correlated with total number of words generated on semantic fluency (r = 0.846; p < 0.01). In contrast, switching was more highly correlated than clustering with total number of words generated on phonemic fluency (r = 0.864; p<0.01). Conclusions. Rules for scoring switching and clustering in our population are provided. Optimal fluency performance requires some type of balance between clustering and switching strategies and should be taken into account in studies regarding verbal fluency.
Association of body composition with sarcopenic obesity in elderly women

The aim of the present study was to investigate the prevalence of sarcopenic obesity and its association with obesity and sarcopenia in elderly Brazilian women. Two hundred and seventy-two sedentary women with a mean age of 66.75 ± 5.38 years were recruited for participation in this study. Obesity was determined by both body mass index and dual-energy X-ray absorptiometry (DXA) evaluations. Sarcopenic obesity diagnosis was established from the ratio between fat-free mass and body surface area as obtained by DXA. There was no association of obesity with sarcopenic obesity (P = 0.424). In contrast, sarcopenia was significantly related to sarcopenic obesity (P < 0.001), although most of the elderly women with sarcopenia (n = 171) did not exhibit sarcopenic obesity. These results highlight the importance of diagnosing sarcopenic obesity as elderly women exhibiting sarcopenia could be either eutrophic or obese.
On the correspondence between morphological and hydrodynamical patterns of groyne fields

This paper examines a variety of recirculation flow patterns that develop in the groyne fields on rivers. A comprehensive data set was obtained from flume experiments at Delft University of Technology and field measurements performed on the Elbe River in Germany. The analysis focuses on patterns of velocity, scour and deposition, and corresponding change of riverbed morphology. The results show that velocity patterns in the groyne fields depend mainly on the aspect ratio between groyne length and length of groyne field. When the aspect ratio is greater than 0·5, a one‐gyre pattern of recirculation develops, while at groyne fields with aspect ratios less than 0·5 a two‐gyre recirculation pattern emerges. The spatial distribution of fine‐sediment deposition between the groynes coincides with the locations of gyres. Moreover, the thickness of the fine‐sediment layer decreases toward the gyre margins where recirculation velocities are greatest. Although the total concentration of suspended sediment in the river does not change considerably as the flow moves through the groyne field, the biological and gravimetrical composition of the suspended material changes substantially within the groyne field. These changes are due to preferential deposition of coarse mineral particles and the replacement of those minerals with finer organic material. Copyright © 2002 John Wiley & Sons, Ltd.
Ex vivo assessment of trabecular bone structure from three-dimensional projection reconstruction MR micro-images

Magnetic resonance (MR) imaging has recently been proposed for assessing osteoporosis and predicting fracture risks. However, accurate acquisition techniques and image analysis protocols for the determination of the trabecular bone structure are yet to be defined. The aim of this study was to assess the potential of projection reconstruction (PR) MR microscopy in the analysis of the three-dimensional (3-D) architecture of trabecular bone and in the prediction of its biomechanical properties. High-resolution 3-D PR images (41 /spl times/ 41 /spl times/ 82 /spl mu/m/sup 3/ voxels) of 15 porcine trabecular bone explants were analyzed to determine the trabecular bone volume fraction (Vv), the mean trabecular thickness (Tb.Th), and the mean trabecular separation (Tb.Sp) using the method of directed secants. These parameters were then compared with those derived from 3-D conventional spin-echo microimages. In both cases, segmentation of the high-resolution images into bone and bone marrow was obtained using a spatial adaptive threshold. The contemporary inclusion of Vv, Tb.Th and 1/Tb.Sp in a multiple regression analysis significantly improved the prediction of Young's modulus (YM). The parameters derived from the PR spin-echo images were found to be stronger predictors of YM (R/sup 2/ = 0.94, p = 0.004) than those derived from conventional spin-echo images (R/sup 2/ = 0.79, p = 0.051). Our study indicates that projection reconstruction MR microscopy appears to be more accurate than the conventional Fourier transform method in the quantification of trabecular bone structure and in the prediction of its biomechanical properties. The proposed PR approach should be readily adaptable to the in vivo MRI studies of osteoporosis.
The Mediating Influence Of School Engagement Between An Adolescent's Contextual Environment And Academic Accomplishment

THE MEDIATING INFLUENCE OF SCHOOL ENGAGEMENT BETWEEN AN ADOLESCENT’S CONTEXTUAL ENVIRONMENT AND ACADEMIC ACCOMPLISHMENT. by NAJIM UDDIN AHMED December 2013 Advisor: Dr. Stephen B. Hillman Major: Educational Psychology Degree: Doctor of Philosophy The current study explored several contexts that may influence an adolescent’s academic performance in school, including school engagement, parenting behaviors, teacher behaviors, peer relationships, and academic self-efficacy. The outcome of interest was academic performance. Participants in this study were 332 ninth through twelfth grade high school students (159 males and 164 females) from a suburban public high school in the midwestern United States. The average age of the students was 16.5. The participants completed seven surveys to measure academic performance in school, including school engagement, parenting behaviors, teacher behaviors, peer relationships, and academic self-efficacy. Mediational analyses were used to investigate if school engagement mediated the relationship between the contextual variables and self-reported academic grades. Partial mediation of school engagement on self-reported academic grades were found for maternal responsiveness, teacher caring, maternal values towards education, paternal values towards education, and academic self-efficacy. School engagement fully mediated the relationship
Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction.

CONTEXT Few studies have examined the association between the number of coronary heart disease risk factors and outcomes of acute myocardial infarction in community practice. OBJECTIVE To determine the association between the number of coronary heart disease risk factors in patients with first myocardial infarction and hospital mortality. DESIGN Observational study from the National Registry of Myocardial Infarction, 1994-2006. PATIENTS We examined the presence and absence of 5 major traditional coronary heart disease risk factors (hypertension, smoking, dyslipidemia, diabetes, and family history of coronary heart disease) and hospital mortality among 542,008 patients with first myocardial infarction and without prior cardiovascular disease. MAIN OUTCOME MEASURE All-cause in-hospital mortality. RESULTS A majority (85.6%) of patients who presented with initial myocardial infarction had at least 1 of the 5 coronary heart disease risk factors, and 14.4% had none of the 5 risk factors. Age varied inversely with the number of coronary heart disease risk factors, from a mean age of 71.5 years with 0 risk factors to 56.7 years with 5 risk factors (P for trend < .001). The total number of in-hospital deaths for all causes was 50,788. Unadjusted in-hospital mortality rates were 14.9%, 10.9%, 7.9%, 5.3%, 4.2%, and 3.6% for patients with 0, 1, 2, 3, 4, and 5 risk factors, respectively. After adjusting for age and other clinical factors, there was an inverse association between the number of coronary heart disease risk factors and hospital mortality adjusted odds ratio (1.54; 95% CI, 1.23-1.94) among individuals with 0 vs 5 risk factors. This association was consistent among several age strata and important patient subgroups. CONCLUSION Among patients with incident acute myocardial infarction without prior cardiovascular disease, in-hospital mortality was inversely related to the number of coronary heart disease risk factors.
Insulin Analogs—Are They Worth It? Yes!

The availability of insulin analogs has offered insulin replacement strategies that are proposed to more closely mimic normal human physiology. Specifically, there are a considerable number of reports demonstrating that prandial insulin analogs (lispro, aspart, glulisine) have pharmacokinetic and pharmacodynamic profiles closer to normal, with resulting faster onset and offset of insulin effect when compared with regular human insulin. In addition, basal insulin analogs (glargine, detemir) have been reported to offer longer duration of action, less variability, more predictability, less hypoglycemia (especially nocturnal), and a favorable effect on weight. However, an argument against use of analog insulins as compared with use of regular or NPH insulin is one that states that the effectiveness and risk of hypoglycemia are the only two valid clinical outcomes that should be used to compare the analog and human insulins. Thus, there remains a debate in some circles that analog insulins are no more effective than human insulins, yet at a much higher financial cost. To provide an in-depth understanding of both sides of the argument, we provide a discussion of this topic as part of this two-part point-counterpoint narrative. In the counterpoint narrative, Dr. Davidson provides his argument and defends his opinion that outside of a few exceptions, analog insulins provide no clinical benefit compared with human insulins but cost much more. In the point narrative presented here, Dr. Grunberger provides a defense of analog insulins and their value in clinical management and suggests that when evaluating the “cost” of therapy, a much more global assessment is needed. —William T. Cefalu Editor in Chief, Diabetes Care
Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma

High TIMP1 expression is associated with poor prognosis in melanoma, where it can bind to CD63 and β1 integrin, inducing PI3-kinase pathway and cell survival. Phosphatidylinositol (3,4,5)-trisphosphate (PIP3), generated under phosphatidylinositol-3-kinase (PI3K) activation, enables the recruitment and activation of protein kinase B (PKB/AKT) and phosphoinositide-dependent kinase 1 (PDK1) at the membrane, resulting in the phosphorylation of a host of other proteins. Using a melanoma progression model, we evaluated the impact of Timp1 and AKT silencing, as well as PI3K, PDK1, and protein kinase C (PKC) inhibitors on aggressiveness characteristics. Timp1 downregulation resulted in decreased anoikis resistance, clonogenicity, dacarbazine resistance, and in vivo tumor growth and lung colonization. In metastatic cells, pAKTThr308 is highly expressed, contributing to anoikis resistance. We showed that PDK1Ser241 and PKCβIISer660 are activated by Timp1 in different stages of melanoma progression, contributing to colony formation and anoikis resistance. Moreover, simultaneous inhibition of Timp1 and AKT in metastatic cells resulted in more effective anoikis inhibition. Our findings demonstrate that Timp1 promotes cell survival with the participation of PDK1 and PKC in melanoma. In addition, Timp1 and AKT act synergistically to confer anoikis resistance in advanced tumor stages. This study brings new insights about the mechanisms by which Timp1 promotes cell survival in melanoma, and points to novel perspectives for therapeutic approaches.
Facile and Eco-Friendly Synthesis of Finger-Like Co3O4 Nanorods for Electrochemical Energy Storage

Co3O4 nanorods were prepared by a facile hydrothermal method. Eco-friendly deionized water rather than organic solvent was used as the hydrothermal media. The as-prepared Co3O4 nanorods are composed of many nanoparticles of 30–50 nm in diameter, forming a finger-like morphology. The Co3O4 electrode shows a specific capacitance of 265 F g−1 at 2 mV s−1 in a supercapacitor and delivers an initial specific discharge capacity as high as 1171 mAh g−1 at a current density of 50 mA g−1 in a lithium ion battery. Excellent cycling stability and electrochemical reversibility of the Co3O4 electrode were also obtained.
Toward Reference Models of Requirements Traceability

Requirements traceability is intended to ensure continued alignment between stakeholder requirements and various outputs of the system development process. To be useful, traces must be organized according to some modeling framework. Indeed, several such frameworks have been proposed, mostly based on theoretical considerations or analysis of other literature. This paper, in contrast, follows an empirical approach. Focus groups and interviews conducted in 26 major software development organizations demonstrate a wide range of traceability practices with distinct low-end and high-end users of traceability. From these observations, reference models comprising the most important kinds of traceability links for various development tasks have been synthesized. The resulting models have been validated in case studies and are incorporated in a number of traceability tools. A detailed case study on the use of the models is presented. Four kinds of traceability link types are identified and critical issues that must be resolved for implementing each type and potential solutions are discussed. Implications for the design of next-generation traceability methods and tools are discussed and illustrated.
Gender reversal in 46XX congenital virilizing adrenal hyperplasia.

OBJECTIVE To review the results of gender reversal in six patients with 46XX congenital virilizing adrenal hyperplasia (CVAH). PATIENTS AND METHODS Fifty-one patients with 46XX CVAH were seen in an 8 year period; 45 were managed by conventional feminizing genitoplasty, but six underwent gender reversal and were managed as males. The clinical decision for gender reversal was made after appropriate counselling and was based primarily on parental choice, this being influenced significantly by a delayed diagnosis in four patients. Surgical management consisted of gonadectomy, excision of Müllerian structures and staged hypospadias repair/ chordee correction in four patients, and circumcision in two completely masculinized children. RESULTS All six boys are well adjusted to their gender of rearing, with ages ranging from 3 years to 16.5 years (mean 8.5) at the time of review. Two children have normal penises and four have a satisfactory result after two-stage repair of hypospadias/chordee. CONCLUSION Most patients with 46XX CVAH are preferably raised as females and require a feminizing genitoplasty. However, the clinical decision may be influenced by many factors, including delay in diagnosis, social bias and the premium on male rearing in certain communities. When male rearing is chosen, early gonadectomy and excision of Müllerian structures, together with staged hypospadias repair, gives satisfactory results.