Miracle-dz/UniFAR-FTUs huggingface dataset:
Cancer patient-centered home care: a new model for health care in oncology

Patient-centered home care is a new model of assistance, which may be integrated with more traditional hospital-centered care especially in selected groups of informed and trained patients. Patient-centered care is based on patients’ needs rather than on prognosis, and takes into account the emotional and psychosocial aspects of the disease. This model may be applied to elderly patients, who present comorbid diseases, but it also fits with the needs of younger fit patients. A specialized multidisciplinary team coordinated by experienced medical oncologists and including pharmacists, psychologists, nurses, and social assistance providers should carry out home care. Other professional figures may be required depending on patients’ needs. Every effort should be made to achieve optimal coordination between the health professionals and the reference hospital and to employ shared evidence-based guidelines, which in turn guarantee safety and efficacy. Comprehensive care has to be easily accessible and requires a high level of education and knowledge of the disease for both the patients and their caregivers. Patient-centered home care represents an important tool to improve quality of life and help cancer patients while also being cost effective.
Demographic information flows

In advertising and content relevancy prediction it is important to understand whether, over time, information that reaches one demographic group spreads to others. In this paper we analyze the query log of a large U.S. web search engine to determine whether the same queries are performed by different demographic groups at different times, particularly when there are query bursts. We obtain aggregate demographic features from user-provided registration information (gender, birth year, ZIP code), U.S. census data, and election results. Given certain queries, we examine trends (from high to low and vice versa) and changes in the statistical spread of the demographic features of users that issue the queries over time periods that include query bursts. Our analysis shows that for certain types of queries (movies and news) distinct demographic groups perform searches at different times, suggesting that information related to such queries flows between them. Queries of movie titles, for instance, tend to be issued first by young and then by older users, where a sudden jump in age occurs upon the movie's release. To the best of our knowledge, this is the first time this problem has been studied using search query logs.
Neurotrophins Induce Formation of Functional Excitatory and Inhibitory Synapses between Cultured Hippocampal Neurons

Cell cultures were used to analyze the role of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in the development of synaptic transmission. Neurons obtained from embryonic day 18 (E18) rat hippocampus and cultured for 2 weeks exhibited extensive spontaneous synaptic activity. By comparison, neurons obtained from E16 hippocampus expressed very low levels of spontaneous or evoked synaptic activity. Neurotrophin treatment produced a sevenfold increase in the number of functional synaptic connections in the E16 cultures. BDNF induced formation of both excitatory and inhibitory synapses, whereas NT-3 induced formation of only excitatory synapses. These effects were independent of serum or the age of the glia bed used for the culture. They were not accompanied by significant changes in synaptic-vesicle-associated proteins or glutamate receptors. Treatment of the cultures with the neurotrophins for 3 d was sufficient to establish the maximal level of functional synapses. During this period, neurotrophins did not affect the viability or the morphology of the excitatory neurons, although they did produce an increase in the number and length of dendrites of the GABAergic neurons. Remarkably, only BDNF caused an increase in the number of axonal branches and in the total length of the axons of the GABAergic neurons. These results support a unique and differential role for neurotrophins in the formation of excitatory and inhibitory synapses in the developing hippocampus.
Optimal safety of conduction through the Purkinje-ventricular junction

Slow conduction through the Purkinje-ventricular junction (PVJ) is thought to result in conduction block and ultimately re-entry under certain pathological conditions. The relationships between tissue structure, conduction velocity and the safety of conduction at such junctions however, are unknown. We developed an electrophysiologically detailed 3D model of the PVJ and varied the Purkinje fibre thickness and intercellular coupling to determine these relationships. We found that both very fast and very slow AP conduction is unsafe, and there exists an optimal velocity providing the maximum safety of conduction through the PVJ. The conduction time delay across the junction is a natural consequence of the electrophysiological and morphological differences between the two tissue types. The delay allows the PVJ to accumulate and pass through sufficient charge to excite the adjacent ventricular tissue.
Routing, spectrum and core allocation in flexgrid SDM networks with multi-core fibers

Space division multiplexing (SDM) over multi-core fiber (MCF) is advocated as a promising technology to overcome the capacity limit of the current single-core optical networks. However, employing the MCF for flexgrid networks necessitates the development of new concepts, such as routing, spectrum and core allocation (RSCA) for traffic demands. The introduction of MCF in the networks mitigates the spectrum continuity constraint of the routing and spectrum assignment (RSA) problem. In fact cores can be switched freely on different links during routing of the network traffic. Similarly, the route disjointness for demands with same allocated spectrum diminishes to core disjointness at the link level. On the other hand, some new issues such as the inter-core crosstalk should be taken into account while solving the RSCA problem. This paper formulates the RSCA network planning problem using the integer linear programming (ILP) formulation. The aim is to optimally minimize the maximum number of spectrum slices required on any core of MCF of a flexgrid SDM network. Furthermore, a scalable and effective heuristic is proposed for the same problem and its performance is compared with the optimal solution. The results show that the proposed algorithm is able to well approximate the optimal solution based on ILP model.
Scan primitives for GPU computing

The scan primitives are powerful, general-purpose data-parallel primitives that are building blocks for a broad range of applications. We describe GPU implementations of these primitives, specifically an efficient formulation and implementation of segmented scan, on NVIDIA GPUs using the CUDA API. Using the scan primitives, we show novel GPU implementations of quicksort and sparse matrix-vector multiply, and analyze the performance of the scan primitives, several sort algorithms that use the scan primitives, and a graphical shallow-water fluid simulation using the scan framework for a tridiagonal matrix solver.
A Syntactic Approach to Discourse Semantics

A correct structural analysis of a discourse is a prerequisite for understanding it. This paper sketches the outline of a discourse grammar which acknowledges several different levels of structure. This grammar, the "Dynamic Discourse Model", uses an Augmented Transition Network parsing mechanism to build a representation of the semantics of a discourse in a stepwise fashion, from left to right, on the basis of the semantic representations of the individual clauses which constitute the discourse. The intermediate states of the parser model the intermediate states of the social situation which generates the discourse.The paper attempts to demonstrate that a discourse may indeed be viewed as constructed by means of sequencing and recursive nesting of discourse constituents. It gives rather detailed examples of discourse structures at various levels, and shows how these structures are described in the framework proposed here.
High-Confidence Discovery of Genetic Network Regulators in Expression Quantitative Trait Loci Data

Expression QTL (eQTL) studies involve the collection of microarray gene expression data and genetic marker data from segregating individuals in a population to search for genetic determinants of differential gene expression. Previous studies have found large numbers of trans-regulated genes (regulated by unlinked genetic loci) that link to a single locus or eQTL “hotspot,” and it would be desirable to find the mechanism of coregulation for these gene groups. However, many difficulties exist with current network reconstruction algorithms such as low power and high computational cost. A common observation for biological networks is that they have a scale-free or power-law architecture. In such an architecture, highly influential nodes exist that have many connections to other nodes. If we assume that this type of architecture applies to genetic networks, then we can simplify the problem of genetic network reconstruction by focusing on discovery of the key regulatory genes at the top of the network. We introduce the concept of “shielding” in which a specific gene expression variable (the shielder) renders a set of other gene expression variables (the shielded genes) independent of the eQTL. We iteratively build networks from the eQTL to the shielder down using tests of conditional independence. We have proposed a novel test for controlling the shielder false-positive rate at a predetermined level by requiring a threshold number of shielded genes per shielder. Using simulation, we have demonstrated that we can control the shielder false-positive rate as well as obtain high shielder and edge specificity. In addition, we have shown our method to be robust to violation of the latent variable assumption, an important feature in the practical application of our method. We have applied our method to a yeast expression QTL data set in which microarray and marker data were collected from the progeny of a backcross of two species of Saccharomyces cerevisiae (Brem et al. 2002). Seven genetic networks have been discovered, and bioinformatic analysis of the discovered regulators and corresponding regulated genes has generated plausible hypotheses for mechanisms of regulation that can be tested in future experiments.
Rhesus expression in a green alga is regulated by CO2

The function of the Rhesus (Rh) complex in the human red cell membrane has been unknown for six decades. Based on the organismal, organ, and tissue distribution of Rh proteins, and on our evidence that their only known paralogues, the ammonium and methylammonium transport proteins (also called methylammonium permeases), are gas channels for NH3, we recently speculated that Rh proteins are biological gas channels for CO2. Like NH3, CO2 differs from other gases in being readily hydrated. We have now tested our speculation by studying expression of the RH1 gene in the photosynthetic microbe Chlamydomonas reinhardtii. Expression of RH1 was high for cells grown in air supplemented with 3% CO2 or shifted from air to high CO2 (3%) for 3 h. Conversely, RH1 expression was low for cells grown in air (0.035% CO2) or shifted from high CO2 to air for 3 h. These results make viable the hypothesis that Rh1 and Rh proteins generally are gas channels for CO2.
Circulating miRNAs: promising biomarkers of human cancer.

BACKGROUND With the development of technologies to look at the expression levels of hundreds of miRNAs at a time and the clear role of miRNAs in cancers, groups began looking at miRNAs profiles of different cancers, especially the circulating miRNAs. We intended to make sure whether circulating miRNAs could be a promising biomarker of human cancers. METHOD We comprehensively searched the Cochrane Library, Medline and EMbase from 1966 to Nov 2009 for the following terms: ("miRNA" or "microRNA") and ("tumor" or "carcinoma") and ("plasma*" or "serum" or "circulating"). Detailed information was extracted from studies that met the inclusion criteria: blood-based miRNAs in human cancers and studies published in the English literature. RESULTS The current review show that different researches use different measurement methods which might impact the results; Cancers treatment might have an affect on circulating miRNAs; some miRNAs are multi-faceted RNA; small sample size might produce selection bias. Furthermore, because of the lack of randomized controlled trials and the heterogeneous nature of the available data, no attempt was made to perform quantitativemeta-analyses. CONCLUSIONS In this review, based on those researches, circulating miRNAs are promising and difficulties for their future application for diagnosing human cancers.
An ultrastructural study of germ cells during ovarian differentiation in Torpedo marmorata

An ultrastructural investigation, performed on embryos, neonates, subadult and adult females, demonstrated that in Torpedo marmorata oogenesis occurs very early in life and continues, in its proliferative phase, also after birth. Clusters of early meiotic cells were already evident in the ovarian cortex of 6‐cm‐long embryos, as well as in the ovary of newborns and three‐month‐old young. Conversely, in the ovaries of subadult and adult females, all the germ cells present were organized into follicles, and no clusters of oogonia and early meiotic cells were generally found in the cortex, except for one adult female where clusters of germ cells not organized in follicles were found in the cortex. These data demonstrated that, in Torpedo marmorata, oogenesis is immediate, and, as oogonia persist after birth, more similar to that of mouse, monkey, rabbit, and ferret (Mauleon Arch Anat Microsc, 1967; 56:125–150; Byskov and Hoyer 1994 ) than to that of human, rat, pig, and guinea pig (Byskov and Hoyer 1994 ). Such a pattern is in agreement with the reproductive strategy of Torpedo, a scantly prolific species with low uterine fecundity. The presence of meiotic cells that are not organized in follicles in one adult female might be consistent with the large individual variability characterizing cartilaginous fishes. The possibility that such a character is typical of mature females should be rejected as oogonia and early meiotic cells were not found inside the totally sectioned gonads of subadult and adult females. Anat Rec 263:237–245, 2001. © 2001 Wiley‐Liss, Inc.
ANALYSIS OF ATMOSPHERIC POLLEN GRAINS IN DURSUNBEY (BALIKESİR), TURKEY

Bu calismada, Dursunbey (Balikesir, Turkiye) atmosferindeki polenler gravimetrik yontem kullanilarak toplanmistir. Toplanan polenler isik mikroskobu ile incelenmis ve cm 2 basina toplam 6265 polen sayilmistir. 24 tanesi odunsu bitkilere (yillik polen indeksinin % 86,17’si), 18 tanesi ise otsu bitkilere (yillik polen indeksinin %13,16’si) ait olan toplam 42 farkli polen tipi tanimlanmistir. Polenlerin az bir kismi ise (42 polen, %0.67) tanimlanmamistir. Siklikla rastlanilan ve yillik toplam polen sayisinin %1'inden fazlasini olusturan polen tipleri bolge icin dominant polen tipleri olarak kabul edilmis olup Pinus L. (%48,23), Cupressaceae Rich. ex Bartl. /Taxaceae Gray (%16,74), Poaceae Barnhart (%8,32), Quercus L. (%5,31), Acer L. (%4,07), Platanus L. (%3,10), Juglans L. (%2,26), Abies Mill. (%1,75), Plantago L. (%1,25), Amaranthaceae Juss. (% 1,22) ve Olea europaea L. (%1,16) polenleri atmosferik polen spektrumunun ana bilesenleri olarak kaydedilmistir. Atmosferdeki en yuksek polen miktari Mayis ayinda tespit edilmis olup, belirlenen dominant polen tiplerinin cogunun daha once polinosisin ana nedenleri olarak rapor edilmeleri dikkat cekicidir.
Embodied Resistance to Persuasion in Advertising

From the literature on resistance to persuasion in advertising, much is known about how people can resist advertising by adopting resistance strategies, such as avoidance, counter-arguing, and selective attention (e.g., Fransen et al., 2015b). However, the role of emotion regulation and bodily expression in resisting persuasion is so far underexplored. This is a surprising observation if one considers that at least 40% of advertisements use positive emotions (i.e., happiness) to persuade people to like the ad, brand, and product (Weinberger et al., 1995). In this article we present a framework in which we apply previous knowledge and theories on emotion regulation and embodiment to the process of resistance to persuasion. In doing so, we specifically address the role of facial expression in the course of resistance. The literature and findings from our own research lead us to propose that people can resist persuasion by controlling their facial expression of emotion when exposed to an advertisement. Controlling the expression of emotions elicited by an ad (for example refusing to smile) might be a fruitful way to resist the ad’s persuasive potential. Moreover, we argue that co-viewers can affect embodied resistance to persuasion. Showing the viability of embodied resistance to persuasion is relevant in view of the fact that ads trying to persuade us by addressing our positive emotions are ubiquitous. Embodied resistance might help people to cope with these induced positive emotions in order to resist advertisements and might therefore work as a novel and effective strategy to resist persuasion.
Determination of network state in switching power converters

In this paper an algorithm for piecewise-linear network state-determination is presented. The algorithm is capable of solving networks that contain piecewise-linear elements with discontinuous characteristics, frequently encountered in power electronics. No prior knowledge about the network operation is required. The algorithm has been implemented in a time-domain simulator for power electronic networks. Application examples with relatively complex power converters are presented. <<ETX>>
Response of Okra (Abelmoschus esculentus (L.) Moench) and Weeds to Plant Spacing and Weeding Regime in a Humid Forest Agro-Ecology of South-Eastern Nigeria

Field experiment was carried out in late 2015 and repeated in early 2016 cropping season at the Teaching and Research Farm of the University of Port Harcourt, Choba, Rivers State, Nigeria to determine the appropriate spacing and weeding regimes for okra production. Three spacing (60 cm x 15 cm, 60 cm x 20 cm and 60 cm x 30 cm) and three weeding regimes [no weeding, weekly weeding, and twice at 3 and 7 weeks after planting (WAP)] were used. The experimental design was a 3 x 3 factorial scheme laid out in a Randomised Complete Block Design (RCBD) with three replications. The results showed that plant spaced at a closer spacing of 60 cm x 15 cm suppressed weeds better than other spacing in both years of study. Okra performance was better at closer spacing of 60 cm x 15 cm than in other spacing regimes. Similarly, weedy check had higher weed growth and least performance than other weeding regimes. There was significant interaction between spacing and weeding regimes. Plant spaced at closer spacing of 60 cm x 15 cm combined Original Research Article Sunday and Udensi; JALSI, 18(3): 1-13, 2018; Article no.JALSI. 43779 2 with weekly weeding plots had the lowest weed density and dry weight of 0.00 plants /m and 0.00 g/m 2 in both years of study. While 60 cm x 30 cm combined with no weeding gave the highest weed density and dry weight (395.00 plants/m 2 and 306.33 plants/m 2 ) and (88.33 plants/m 2 and 95.33 g/m) in the late and early 2015 and 2016 cropping seasons respectively. The interaction effect further showed that the highest fresh pod yield was obtained from plant spaced at 60 cm x 15cm with weekly weeding ( 3.02 t/ha and 2.26 t/ha) followed by 60 cm x 15 cm with twice weeding at 3 and 7 WAP (2.96 and 2.22 t/ha). While, plant spaced at 60 cm x 30 cm with no weeding had the lowest fresh pod yield (0.08 t/ha and 0.03 t/ha). Since, the yield obtained from 60 cm x 15 cm with twice weeding (3 and 7 WAP) was not statistically different from 60 cm x 15 cm weekly weeding, for economic considering the former could be recommended.
Revenues for Online Newspapers: Owner and User Perceptions

The newspaper industry faces hard questions about business models and economic success for their online newspaper ventures. Managers, editors-in-chief and designers at nine local newspapers in Sweden were interviewed. In addition, semi-structured interviews with 153 users/readers of the news services of these nine newspapers were also conducted. The analysis reveals differences in digital news product content and revenue generation. The paper suggests a new business model for digital news products that includes content-based revenue generation through personalization, archiving and versioning, approaches to advertising that involve more highly targeted market intermediation, and non-news activities covering advertisers and information brokerage. Results suggest that management and users agree on the importance of archives, personalized and deep news content, and a role for the newspaper as intermediary. However, users are not willing to pay for increased multimedia or an e-commerce site sponsored by the news site.
Spore‐forming organisms in platelet concentrates: a challenge in transfusion bacterial safety

summary Bacterial detection and pathogen reduction are widely used methods of minimizing the risk of transfusion‐transmitted bacterial infection. But, bacterial spores are highly resistant to chemical and physical agents. In this study, we assessed the bacterial proliferation of spore‐forming organisms seeded into platelet concentrates (PCs) to demonstrate that spores can enter the vegetative state in PCs during storage. In the in vitro study, PCs were inoculated with 1–10 spores mL−1of Bacillus cereus (n = 1), Bacillus subtilis (n = 2) and Clostridium sporogenes (n = 2). Sampling was performed during 6‐day aerobic storage at 22 °C. The presence of bacteria was assessed by plating culture, automated culture and real‐time reverse transcriptase–polymerase chain reaction (RT‐PCR). Spores of the C. sporogenes do not enter the vegetative phase under PC storage conditions, whereas B. subtilis and B. cereus showed growth in the PC and could be detected using RT‐PCR and automated culture. Depending on the species and inoculums, bacterial spores may enter the vegetative phase during PC storage and can be detected by bacterial detection methods.