Miracle-dz/UniFAR-FTUs huggingface dataset:
Laser-assisted dacryocystorhinostomy: a viable treatment option?

Purpose of review Improvements in endoscopic instrumentation and evolving laser technologies have renewed interest in laser-assisted endonasal applications, and an increasing number of lacrimal surgeons have focused on laser-assisted approaches to dacryocystorhinostomy (DCR). The purpose of this review was to assess the clinical efficacy of laser-assisted DCR techniques with a particular focus on the endocanalicular approach and to describe various laser systems and their associated tissue effects. Recent findings Recent studies of endocanalicular laser DCR suggest favorable success rates that are comparable with external and endonasal endoscopic DCR, although there is a shortage of robust, prospective, randomized studies. Summary Recent evidence suggests that endocanalicular laser DCR is a well tolerated, viable treatment option for nasolacrimal duct obstruction in selected patients with favorable results and shorter operative times. More recent studies seem to suggest improvements in success rates compared with older studies, although additional, well designed, comparative studies are needed.
The politics of time: Deleuze, duration and alter-globalisation

Alex Callinicos, in An Anti-Capitalist Manifesto, criticises Gilles Deleuze's work for its ostensible apolitical aestheticism, and for its correlative undermining of the concept of authenticity so important to political activism. He accordingly valorises the November 1999 mass protests in Seattle against the WTO and economic globalisation as expressing reinvigorated neo-Marxist social critique and rejuvenated belief in authenticity. Both of these, he maintains, are underpinned by insight into the problematic politico-economic excesses of neoliberalism and recognition of the philosophical limitations of post-structural thought, particularly that of Deleuze. Against the backdrop of such criticism, this article considers the value of Deleuze's (and Félix Guattari's) politicisation of time and memory, as a heuristic device that renders conspicuous the durational concerns currently animating the alter-globalisation struggle. Durational concerns which, since the Second World War, have been successively marginalised through developmental time and neoliberal time, and which now face displacement, yet again, through attempts (such as those of Callinicos) to subsume them within the time of dialectical materialism. Arguably, this move threatens to curb the diverse temporalities currently being produced by alter-globalisation supporters, using the internet and related digital media, as part of a tactical effort to resist neoliberal hegemony.
O campo de estudo sobre redes de cooperação interorganizacional no Brasil

The aim of this article is to provide more evidence on the characteristics of the field of studies of inter-organizational cooperation networks in the Brazilian context. The field research was carried out through a bibliometric study of 116 academic articles published in the major scientific journals in the field of organizational studies between 2000 and 2006. The methodological procedures followed the guidelines of the study of Oliver and Ebers (1998). The main results obtained from the bibliometric study were: (1) four theories - strategy, resource dependence, network and institutional - consolidate a predominant conceptual base in the orientation of the studies; (2) the research was mainly carried out by qualitative and cross sectional methods; (3) horizontal networks, material and immaterial antecedent resources, as well as the learning and innovation outcomes, were the main focus of the studies in the Brazilian context; (4) the theories of strategy, resource dependence, transaction, social network and institutional costs are considerably over-represented with regard to their Bonacich centrality; (5) the network theory had a strong level of betweenness centrality among the many theories considered in this study.
Statistical geometry based prediction of nonsynonymous SNP functional effects using random forest and neuro‐fuzzy classifiers

There is substantial interest in methods designed to predict the effect of nonsynonymous single nucleotide polymorphisms (nsSNPs) on protein function, given their potential relationship to heritable diseases. Current state‐of‐the‐art supervised machine learning algorithms, such as random forest (RF), train models that classify single amino acid mutations in proteins as either neutral or deleterious to function. However, it is frequently the case that the functional effect of a polymorphism on a protein resides between these two extremes. The utilization of classifiers that incorporate fuzzy logic provides a natural extension in order to account for the spectrum of possible functional consequences. We generated a dataset of single amino acid substitutions in human proteins having known three‐dimensional structures. Each variant was uniquely represented as a feature vector that included computational geometry and knowledge‐based statistical potential predictors obtained though application of Delaunay tessellation of protein structures. Additional attributes consisted of physicochemical properties of the native and replacement amino acids as well as topological location of the mutated residue position in the solved structure. Classification performance of the RF algorithm was evaluated on a training set consisting of the disease‐associated and neutral nsSNPs taken from our dataset, and attributes were ranked according to their relative importance. Similarly, we evaluated the performance of adaptive neuro‐fuzzy inference system (ANFIS). The utility of statistical geometry predictors was compared with that of traditional structural and evolutionary attributes employed by other researchers, revealing an equally effective yet complementary methodology. Among all attributes in our feature set, the statistical geometry predictors were found to be the most highly ranked. On the basis of the AUC (area under the ROC curve) measure of performance, the ANFIS and RF models were equally effective when only statistical geometry features were utilized. Tenfold cross‐validation studies evaluating AUC, balanced error rate (BER), and Matthew's correlation coefficient (MCC) showed that our RF model was at least comparable with the well‐established methods of SIFT and PolyPhen. The trained RF and ANFIS models were each subsequently used to predict the disease potential of human nsSNPs in our dataset that are currently unclassified (http://rna.gmu.edu/FuzzySnps/). Proteins 2008. © 2008 Wiley‐Liss, Inc.
Genocide or a Failure to Gel? Racism, History and Nationalism in Australian Talk

In a context of wide media attention to public debates about the social, political and epistemic entitlements of different groups within Australian society, an understanding of the rhetorical resources and the discursive work doen by differing constructions of `race', has become an important local issue. This article examines data from discussions between two groups of (non-indigenous) university students on a range of contemporary issues concerning race relations in Australia. Participants drew on four common discursive themes when discussing Aboriginal people. These were: an imperialist narrative of Australian history exculpatory of colonialism; an economic-rationalist/neo-liberal discourse of `productivity' and entitlement managing accountability for a contemporary Aboriginal `plight'; a local discourse of balance and even-handedness which discounted the seriousness of discrimination and racism in Australia; and a nationalist discourse stressing the necessity of all members collectively identifying as `Australian'. These interpretative resources are illustrated and discussed in terms of their rhetorical organization and social consequences. The international pervasiveness of a range of modern racist tropes and the local cultural specificity of their working-up are discussed.
SPEED BUMPS ON THE WAY TO A CAREER: HOW REJECTION SHAPES DECISIONS OF COLLEGE STUDENTS

The purpose of this study was to understand how undergraduate students manage the barrier of being denied admission to a School of Education at a particular university, how they make career choices, and how they come to understand their decisions. Marcia (1966) and Josselson's (1987) identity development statuses, Baxter Magolda's (2000) development of self-authorship, and the Social Cognitive Career Theory (Lent, Brown, & Hackett, 1994, 1996), were used as theoretical frameworks to examine and describe college students' career decision making processes. A basic qualitative design was utilized to collect data from participants. Eight students who were denied admission to a large, Midwestern, research university's teacher preparation program agreed to an interview for this study. These interviews were used to create cases to describe their perspectives of the denial decision and how they understood their career options. Themes across cases identify a reciprocal relationship between identity and cognitive development levels and how these influence career decision making. How interests, choices, and goals develop prior to a career barrier is explored, as well as decision making following a barrier. This study focused on an objectively defined barrier to students achieving career goals which differs from research on perceived career barriers. A variety of responses emerged to the objective barrier based on the student's development, however, all participants maintained an interest in teaching. Implications from this study exist for higher education as well as for alternative certification programs.
Medium-Chain Fatty Acids Affect Citrinin Production in the Filamentous Fungus Monascus ruber

ABSTRACT During submerged culture in the presence of glucose and glutamate, the filamentous fungus Monascus ruber produces water-soluble red pigments together with citrinin, a mycotoxin with nephrotoxic and hepatoxic effects on animals. Analysis of the13C-pigment molecules from mycelia cultivated with [1-13C]-, [2-13C]-, or [1,2-13C]acetate by 13C nuclear magnetic resonance indicated that the biosynthesis of the red pigments used both the polyketide pathway, to generate the chromophore structure, and the fatty acid synthesis pathway, to produce a medium-chain fatty acid (octanoic acid) which was then bound to the chromophore by atrans-esterification reaction. Hence, to enhance pigment production, we tried to short-circuit the de novo synthesis of medium-chain fatty acids by adding them to the culture broth. Of fatty acids with carbon chains ranging from 6 to 18 carbon atoms, only octanoic acid showed a 30 to 50% stimulation of red pigment production, by a mechanism which, in contrast to expectation, did not involve its direct trans-esterification on the chromophore backbone. However, the medium- and long-chain fatty acids tested were readily assimilated by the fungus, and in the case of fatty acids ranging from 8 to 12 carbon atoms, 30 to 40% of their initial amount transiently accumulated in the growth medium in the form of the corresponding methylketone 1 carbon unit shorter. Very interestingly, these fatty acids or their corresponding methylketones caused a strong reduction in, or even a complete inhibition of, citrinin production byM. ruber when they were added to the medium. Several data indicated that this effect could be due to the degradation of the newly synthesized citrinin (or an intermediate in the citrinin pathway) by hydrogen peroxide resulting from peroxisome proliferation induced by medium-chain fatty acids or methylketones.
The Relevance of Systematic Reviews to Educational Policy and Practice

This paper argues that educational policy and practice has much to gain from systematic reviews and other methods of research synthesis. Different types of reviews are considered, including narrative reviews, vote-counting reviews, meta-analyses, best evidence synthesis, and meta-ethnography. It is argued that systematic reviews allow researchers, and users of research, to go beyond the limitations of single studies and to discover the consistencies and variability in seemingly similar studies. This, in turn, allows for some degree of cumulative knowledge of educational research that is often missing in the absence of systematic reviews. Some limitations of systematic reviews and research synthesis for educational policy and practice are also discussed. The work of the Campbell Collaboration as an international organisation that promotes the use of systematic reviews in educational policy and practice is outlined.
Mercury evidence for pulsed volcanism during the end-Triassic mass extinction

Significance The end of the Triassic Period (∼201.5 million years ago) witnessed one of the largest mass extinctions of animal life known from Earth history. This extinction is suggested to have coincided with and been caused by one of the largest known episodes of volcanic activity in Earth’s history. This study examines mercury concentrations of sediments from around the world that record this extinction. Mercury is emitted in gaseous form during volcanism, and subsequently deposited in sediments. We find numerous pulsed elevations of mercury concentrations in end-Triassic sediments. These peaks show that the mass extinction coincided with large-scale, episodic, volcanism. Such episodic volcanism likely perturbed the global environment over a long period of time and strongly delayed ecological recovery. The Central Atlantic Magmatic Province (CAMP) has long been proposed as having a causal relationship with the end-Triassic extinction event (∼201.5 Ma). In North America and northern Africa, CAMP is preserved as multiple basaltic units interbedded with uppermost Triassic to lowermost Jurassic sediments. However, it has been unclear whether this apparent pulsing was a local feature, or if pulses in the intensity of CAMP volcanism characterized the emplacement of the province as a whole. Here, six geographically widespread Triassic–Jurassic records, representing varied paleoenvironments, are analyzed for mercury (Hg) concentrations and Hg/total organic carbon (Hg/TOC) ratios. Volcanism is a major source of mercury to the modern environment. Clear increases in Hg and Hg/TOC are observed at the end-Triassic extinction horizon, confirming that a volcanically induced global Hg cycle perturbation occurred at that time. The established correlation between the extinction horizon and lowest CAMP basalts allows this sedimentary Hg excursion to be stratigraphically tied to a specific flood basalt unit, strengthening the case for volcanic Hg as the driver of sedimentary Hg/TOC spikes. Additional Hg/TOC peaks are also documented between the extinction horizon and the Triassic–Jurassic boundary (separated by ∼200 ky), supporting pulsatory intensity of CAMP volcanism across the entire province and providing direct evidence for episodic volatile release during the initial stages of CAMP emplacement. Pulsatory volcanism, and associated perturbations in the ocean–atmosphere system, likely had profound implications for the rate and magnitude of the end-Triassic mass extinction and subsequent biotic recovery.
Disambiguating the Documentation of Variability in Software Product Lines: A Separation of Concerns, Formalization and Automated Analysis

Feature diagrams are a popular means for documenting variability in software product line engineering. When examining feature diagrams in the literature and from industry, we observed that the same modelling concepts are used for documenting two different kinds of variability: (1) product line variability, which reflects decisions of product management on how the systems that belong to the product line should vary, and (2) software variability, which reflects the ability of the reusable product line artefacts to be customized or configured. To disambiguate the documentation of variability, we follow previous suggestions to relate orthogonal variability models (OVMs) to feature diagrams. This paper reuses an existing formalization of feature diagrams, but introduces a formalization of OVMs. Then, the relationships between the two kinds of models are formalized as well. Besides a precise definition of the languages and the links, the important benefit of this formalization is that it serves as a foundation for a tool supporting automated reasoning on variability. This tool can, e.g., analyse whether the product line artefacts are flexible enough to build all the systems that should belong to the product line.
Mumpsimus and the Mything of the Individualistic Entrepreneur

The purpose of this article is to explore the persistence, in the face of considerable evidence to the contrary, of the notion that entrepreneurship is a purely individualistic practice. It may be that taking account of the dynamics of social conditioning, social interaction and the embedding process is simply too complex to be used as a heuristic; instead the convenient myth of the romantic of the heroic individual holds sway.The methodological issue of an under-socialized concept of entrepreneurship is considered, showing how methodological individualism could easily arise in explanations that risk employing contradictory levels of analysis and explanation.To conceive the entrepreneur as an atomistic and isolated agent of change is to ignore the milieu that supports, drives, produces and receives the entrepreneurial process.The entrepreneurial agent encounters the social, may be shaped by it, but in turn, employs his or her agency to change the structure.
Genetic control of antibody responses induced by recombinant Mycobacterium bovis BCG expressing a foreign antigen

Recombinant Mycobacterium bovis BCG expressing foreign antigens represents a promising candidate for the development of future vaccines and was shown in several experimental models to induce protective immunity against bacterial or parasitic infections. Innate resistance to BCG infection is under genetic control and could modify the immune responses induced against an antigen delivered by such engineered microorganisms. To investigate this question, we analyzed the immune responses of various inbred strains of mice to recombinant BCG expressing beta-galactosidase. These experiments demonstrated that BALB/c mice developed strong antibody responses against BCG expressing beta-galactosidase under the control of two different promoters. In contrast, C57BL/6, C3H, and CBA mice produced high anti-beta-galactosidase antibody titers only when immunized with recombinant BCG expressing beta-galactosidase under the control of the pblaF* promoter, which induced the production of high levels of this antigen. This difference in mouse responsiveness to recombinant BCG was not due to innate resistance to BCG infection, since similar immune responses were induced in Ity(r) and Ity(s) congenic strains of mice. In contrast, the analysis of anti-beta-galactosidase antibody responses of H-2 congenic mice in two different genetic backgrounds demonstrated that H-2 genes are involved in the immune responsiveness to beta-galactosidase delivered by recombinant BCG. Together, these results demonstrate that immune responses to an antigen delivered by recombinant BCG are under complex genetic influences which could play a crucial role in the efficiency of future recombinant BCG vaccines.
Newspapers, Facebook and Twitter

Social media, such as Facebook, Twitter, YouTube and many other services, have established themselves as part of the networked and increasingly hybrid public sphere, extending and transforming it to allow for and facilitate access to all kinds of content and participants. By their sheer ubiquity, these media contribute to changing media ecologies and open new ways and forms of communications between citizens and their representatives. During election campaigns, political parties and their candidates have a number of ways of seeking to mobilise voters by attracting attention to the parties' issues and top candidates. Many of these involve processes of mediatisation, that is, parties and politicians adapt their practices and messages to formats, deadlines and genres that are journalistically attractive. This study seeks to map and understand intermedial agenda setting between social media and traditional news media by analysing data from both local journalism and the social media activity of local politicians during the 2011 Norwegian local election campaigns. Our findings show that local politicians were active on social media as part of their campaigning, yet there was surprisingly little evidence that social media content travelled to local newspapers and contributed to agenda setting, thereby contradicting findings from other settings stating that social media have become established journalistic sources. We suggest that one explanation may reflect the nature of Norwegian politics and culture in which the distance between journalists, citizens and politicians is proximate.
A care pathway approach to identifying factors that impact on diagnosis of heart disease in British Pakistani women

Purpose – The authors examined the cardiac care pathway with the aim of identifying factors that impact on diagnosis and treatment of coronary heart disease in British Pakistani women.Design/methodology/approach – This is an exploratory qualitative study. In depth interviews and focus groups with an opportunistic sample of Pakistani women and a purposive sample of clinicians working at different points along the care pathway were conducted. The authors used a pathways to care approach to illustrate how their individual and cumulative effect may contribute to differential receipt of treatment, including revascularisation, and health inequalities.Findings – Four major issues were identified: complex life circumstances; “atypical” presentation and symptomatology; problems related to investigative testing; and poor communication. Mapping these barriers onto the Pathways to Care Model provided valuable insight into their impact on patients' progression through the different stages of the care pathway.Research .
Secondary dormancy dynamics depends on primary dormancy status in Arabidopsis thaliana

Abstract Seed dormancy can prevent germination under unfavourable conditions that reduce the chances of seedling survival. Freshly harvested seeds often have strong primary dormancy that depends on the temperature experienced by the maternal plant and which is gradually released through afterripening. However, seeds can be induced into secondary dormancy if they experience conditions or cues of future unfavourable conditions. Whether this secondary dormancy induction is influenced by seed-maturation conditions and primary dormancy has not been explored in depth. In this study, we examined secondary dormancy induction in seeds of Arabidopsis thaliana matured under different temperatures and with different levels of afterripening. We found that low water potential and a range of temperatures, from 8°C to 35°C, induced secondary dormancy. Secondary dormancy induction was affected by the state of primary dormancy of the seeds. Specifically, afterripening had a non-monotonic effect on the ability to be induced into secondary dormancy by stratification; first increasing in sensitivity as afterripening proceeded, then declining in sensitivity after 5 months of afterripening, finally increasing again by 18 months of afterripening. Seed-maturation temperature sometimes had effects that were independent of expressed primary dormancy, such that seeds that had matured at low temperature, but which had comparable germination proportions as seeds matured at warmer temperatures, were more easily induced into secondary dormancy. Because seed-maturation temperature is a cue of when seeds were matured and dispersed, these results suggest that the interaction of seed-maturation temperature, afterripening and post-dispersal conditions all combine to regulate the time of year of seed germination.