Miracle-dz/UniFAR-FTUs huggingface dataset:
Video game use among children and adolescents with attention deficit hyperactivity disorder

Electronic media use by children and adolescents is growing each year. From 2004 to 2009, electronic daily media exposure increased from six hours and twentyone minutes to seven hours and thirty-eight minutes. The ubiquity of electronic media among youth is apparent in our technology-driven culture; however, more research on video gaming patterns and characteristics of children and adolescents with developmental disabilities is warranted specifically, individuals with Attention Deficit Hyperactivity Disorder (ADHD). As of 2011, the number of children and adolescents with ADHD in schools represents 6.4 million in the USA. Given that ADHD is a prevalent disability in children and adolescents, there is a need to be able to effectively discern the most time and cost effective interventions for youth with ADHD, including those that are electronically mediated. Thus, this study examines parent-reported video game use among children and adolescents with ADHD collected from a clinical sample, and compares their rates of use with previously reported data from national samples. Parents completed the Children’s Use of Video Games and Digital Media, comprised of 13 questions that assessed ADHD type characteristics expressed during activities, duration spent across different activities, parent involvement, perceptions, and parent use of video games. The present study found that only weekend/vacation days video game play for youth with ADHD was reported by parents as more frequent than video game play among the national sample reported by Rideout and colleagues. Male youth statistically played more video games than female youth, and the only statistical age difference was found among 11-14 year-old children/adolescents and 5-7 year-old children, with older children/adolescents playing more video games. The majority of parents in the present sample endorsed that their children demonstrated fewer ADHD behaviors during video game play (i.e., less inattention, hyperactivity, and disorganization). In conclusion, the variability of video game and media use indicate potential areas to capitalize on teachable moments for ADHD youth while in the home. Findings from this study are expected to inform future research and practice with children with ADHD, particularly in the areas of effective parenting, intervention development, and the use of technology-based learning strategies.
Analysis of Maize (Zea mays L.) Seedling Roots with the High-Throughput Image Analysis Tool ARIA (Automatic Root Image Analysis)

The maize root system is crucial for plant establishment as well as water and nutrient uptake. There is substantial genetic and phenotypic variation for root architecture, which gives opportunity for selection. Root traits, however, have not been used as selection criterion mainly due to the difficulty in measuring them, as well as their quantitative mode of inheritance. Seedling root traits offer an opportunity to study multiple individuals and to enable repeated measurements per year as compared to adult root phenotyping. We developed a new software framework to capture various traits from a single image of seedling roots. This framework is based on the mathematical notion of converting images of roots into an equivalent graph. This allows automated querying of multiple traits simply as graph operations. This framework is furthermore extendable to 3D tomography image data. In order to evaluate this tool, a subset of the 384 inbred lines from the Ames panel, for which extensive genotype by sequencing data are available, was investigated. A genome wide association study was applied to this panel for two traits, Total Root Length and Total Surface Area, captured from seedling root images from WinRhizo Pro 9.0 and the current framework (called ARIA) for comparison using 135,311 single nucleotide polymorphism markers. The trait Total Root Length was found to have significant SNPs in similar regions of the genome when analyzed by both programs. This high-throughput trait capture software system allows for large phenotyping experiments and can help to establish relationships between developmental stages between seedling and adult traits in the future.
Prosodic adaptations to pitch perturbation in running speech.

PURPOSE A feedback perturbation paradigm was used to investigate whether prosodic cues are controlled independently or in an integrated fashion during sentence production. METHOD Twenty-one healthy speakers of American English were asked to produce sentences with emphatic stress while receiving real-time auditory feedback of their productions. The fundamental frequency (F0) of the stressed word in each 4-word sentence was selectively shifted in a sensorimotor adaptation protocol. Speakers experienced either an upward or a downward shift of the stressed word, which gradually altered the perceived stress of the sentence. RESULTS Participants in the Up and Down groups adapted to F0 shifts by altering the contrast between stressed and unstressed words differentially, such that the two groups deviated from each other in the perturbation phase. Furthermore, selective F0 perturbation in sentences with emphatic stress resulted in compensatory changes in both F0 and intensity. CONCLUSIONS Present findings suggest that F0 and intensity are controlled in an integrated fashion to maintain the contrast between stressed and unstressed words. When a cue is impaired through perturbation, speakers not only oppose the perturbation but enhance other prosodic cues to achieve emphatic stress.
Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart

G protein-coupled receptors (GPCRs) are critical for cardiovascular physiology. Cardiac cells express >100 nonchemosensory GPCRs, indicating that important physiological and potential therapeutic targets remain to be discovered. Moreover, there is a growing appreciation that members of the large, distinct taste and odorant GPCR families have specific functions in tissues beyond the oronasal cavity, including in the brain, gastrointestinal tract and respiratory system. To date, these chemosensory GPCRs have not been systematically studied in the heart. We performed RT-qPCR taste receptor screens in rodent and human heart tissues that revealed discrete subsets of type 2 taste receptors (TAS2/Tas2) as well as Tas1r1 and Tas1r3 (comprising the umami receptor) are expressed. These taste GPCRs are present in cultured cardiac myocytes and fibroblasts, and by in situ hybridization can be visualized across the myocardium in isolated cardiac cells. Tas1r1 gene-targeted mice (Tas1r1Cre/Rosa26tdRFP) strikingly recapitulated these data. In vivo taste receptor expression levels were developmentally regulated in the postnatal period. Intriguingly, several Tas2rs were upregulated in cultured rat myocytes and in mouse heart in vivo following starvation. The discovery of taste GPCRs in the heart opens an exciting new field of cardiac research. We predict that these taste receptors may function as nutrient sensors in the heart.
An adaptive Watermarking Approach for Medical Imaging Using Swarm Intelligent

In this paper we present a secure patient medical images and authentication scheme which enhances the security, confidentiality and integrity of medical images transmitted through the Internet. This paper proposes a watermarking by invoking particle swarm optimization (PSO) technique in adaptive quantization index modulation and singular value decomposition in conjunction with discrete wavelet transform (DWT) and discrete cosine transform (DCT). The proposed approach promotes the robustness and watermarked image quality. The experimental results show that the proposed algorithm yields a watermark which is invisible to human eyes, robust against a wide variety of common attacks and reliable enough for tracing colluders.
[Sexual traumatic events and neurotic disorders picture--sexuality-related and sexuality-unrelated symptoms].

INTRODUCTION There is an ample evidence of the impact of severe traumatic events, such as sexual abuse in childhood, on the formation of disorders--especially the non-psychotic ones: sexual, neurotic and personality. So far, an increase of the risk with the accumulation of traumatic factors has been indicated, but less attention has been paid to adverse events such as lack of sexual education, negative attitudes of the caregivers towards sexuality, etc. AIM Assessment of the risk of such adverse events in childhood and adolescence, concerning the symptoms from the area of sexuality as well as other neurotic disorders areas. METHOD The coexistence of the earlier life circumstances and currently present symptoms was examined on the basis of KO "0" Symptom Checklist and Life Inventory, completed prior to treatment in a day hospital for neurotic disorders. RESULTS In the group of 2582 females and 1347 males, there was a significant prevalence of symptoms related to sexuality, as well as of other neurotic symptoms. Patients reported traumatic events of varying frequency (from a relatively rare incest, to much more frequent sense of lack of sex education). Regression analyses showed a significant relationship between the analyzed events and symptoms, for instance, lack of sexual satisfaction in adulthood co-occurred in women with punishing for childhood sexual plays or masturbation. The other analyzed symptoms--'non-sexual', such as panic attacks, were not so clearly related to the burdensome circumstances. CONCLUSIONS The presence of adverse life events concerning sexuality, not necessarily the most serious ones e.g. abuses, but such as inadequate sex education, child punishing for masturbation or sexual plays, unwanted sexual initiation, are associated with a higher occurrence of most of the analyzed symptoms in the sphere of sexuality. Weaker connection for other than sexual neurotic symptoms suggests that the impact of childhood sexual trauma is mainly focused on the area of sexual dysfunctions.
Absence of Whisker-Related Pattern Formation in Mice with NMDA Receptors Lacking Coincidence Detection Properties and Calcium Signaling

Precise refinement of synaptic connectivity is the result of activity-dependent mechanisms in which coincidence-dependent calcium signaling by NMDA receptors (NMDARs) under control of the voltage-dependent Mg2+ block might play a special role. In the developing rodent trigeminal system, the pattern of synaptic connections between whisker-specific inputs and their target cells in the brainstem is refined to form functionally and morphologically distinct units (barrelettes). To test the role of NMDA receptor signaling in this process, we introduced the N598R mutation into the native NR1 gene. This leads to the expression of functional NMDARs that are Mg2+ insensitive and Ca2+impermeable. Newborn mice expressing exclusively NR1 N598R-containing NMDARs do not show any whisker-related patterning in the brainstem, whereas the topographic projection of trigeminal afferents and gross brain morphology appear normal. Furthermore, the NR1 N598R mutation does not affect expression levels of NMDAR subunits and other important neurotransmitter receptors. Our results show that coincidence detection by, and/or Ca2+ permeability of, NMDARs is necessary for the development of somatotopic maps in the brainstem and suggest that highly specific signaling underlies synaptic refinement.
p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression

SV40 large T-antigen (T-ag) has been known for decades to inactivate the tumor suppressor p53 by sequestration and additional mechanisms. Our present study revealed that the struggle between p53 and T-ag begins very early in the infection cycle. We found that p53 is activated early after SV40 infection and defends the host against the infection. Using live cell imaging and single cell analyses we found that p53 dynamics are variable among individual cells, with only a subset of cells activating p53 immediately after SV40 infection. This cell-to-cell variabilty had clear consequences on the outcome of the infection. None of the cells with elevated p53 at the beginning of the infection proceeded to express T-ag, suggesting a p53-dependent decision between abortive and productive infection. In addition, we show that artificial elevation of p53 levels prior to the infection reduces infection efficiency, supporting a role for p53 in defending against SV40. We further found that the p53-mediated host defense mechanism against SV40 is not facilitated by apoptosis nor via interferon-stimulated genes. Instead p53 binds to the viral DNA at the T-ag promoter region, prevents its transcriptional activation by Sp1, and halts the progress of the infection. These findings shed new light on the long studied struggle between SV40 T-ag and p53, as developed during virus-host coevolution. Our studies indicate that the fate of SV40 infection is determined as soon as the viral DNA enters the nucleus, before the onset of viral gene expression.
Implementing living room theatre activities for people with dementia on nursing home wards: a process evaluation study

Objectives: A new communication method, the ‘Veder Method’, was implemented in the Netherlands. This method uses theatrical stimuli in combination with proven person-centred communication methods. Care staff was trained to apply the Veder Method in a ‘living room theatre activity’ for people with dementia. This study evaluates the implementation of the Veder Method on psychogeriatric nursing home wards. Methods: Facilitators and barriers to train staff and implement the Veder Method in psychogeriatric nursing homes were identified by conducting semi-structured interviews with 12 stakeholders who were involved in the implementation, and five focus groups with 35 trained care staff. The interviews and focus groups were transcribed verbatim, and two independent researchers analysed the content of the transcripts. The Implementation Process Evaluation (IPE) Framework was used to categorize the data and the 7s-model to contextualize the qualitative findings. Results: A structured overview of facilitators and barriers in different stages of the implementation process is presented. Positive reactions in residents and more reciprocity in caregiver-resident contact motivated trained care staff to work with the Veder Method. An action plan, executive support, the visibility of the method in the organization and a pioneer group that initiated implementation were essential for successful implementation. High work pressure for the care staff was a hindering factor. Conclusion: Respondents experienced the added value of the Veder Method. The facilitators and barriers to implementation we identified in this study can help to implement and disseminate the successful Veder Method and other person-centred communication methods in psychogeriatric nursing homes effectively.
Quantitative separation of murine leukemia virus proteins by reversed-phase high-pressure liquid chromatography reveals newly described gag and env cleavage products

The structural proteins of murine type C retroviruses are proteolytic cleavage products of two different precursor polyproteins coded by the viral gag and env genes. To further investigate the nature and number of proteolytic cleavages involved in virus maturation, we quantitatively isolated the structural proteins of the Rauscher and Moloney strains of type C murine leukemia virus (R-MuLV and M-MuLV, respectively) by reversed-phase high-pressure liquid chromatography. Proteins and polypeptides isolated from R-MuLV included p10, p12, p15, p30, p15(E), gp69, and gp71 and three previously undescribed virus components designated here as p10', p2(E), and p2(E). Homologous proteins and polypeptides were isolated from M-MuLV. Complete or partial amino acid sequences of all the proteins listed above were either determined in this study or were available in previous reports from this laboratory. These data were compared with those from the translation of the M-MuLV proviral DNA sequence (Shinnick et al., Nature [London] 293:543-548, 1981) to determine the exact nature of proteolytic cleavages for all the structural proteins described above and to determine the origin of p10' and p2(E)s. The results showed that, during proteolytic processing of gp80env from M-MuLV (M-gp 80env), a single Arg residue was excised between gp70 and p15(E) and a single peptide bond was cleaved between p15(E) and p2(E). The structure of M-gPr80env is gp70-(Arg)-p15(E)-p2(E). The data suggest that proteolytic cleavage sites in R-gp85env are identical to corresponding cleavage sites in M-gp80env. The p2(E)s are shown to be different genetic variants of p2(E) present in the uncloned-virus preparations. The data for R- and M-p10's shows that they are cleavage products of the gag precursor with the structure p10-Thr-Leu-Asp-Asp-OH. The complete structure of Pr65gag is p15-p12-p30-p10'. Stoichiometries of the gag and env cleavage products in mature R- and M-MuLV were determined. In each virus, gag cleavage products (p15, p12, p30, and p10 plus p10') were found in equimolar amounts and p15(E)s were equimolar with p2(E)s. The stoichiometry of gag to env cleavage products was 4:1. These data are consistent with the proposal that proteolytic processing of precursor polyproteins occurs after virus assembly and that the C-terminal portion of Pr15(E) [i.e., p15(E)-p2(E)] is located on the inner side of the lipid bilayer of the virus.
Plasma adiponectin level is associated with insulin-stimulated nonoxidative glucose disposal.

CONTEXT Impaired nonoxidative glucose disposal and decrease in mitochondrial glucose oxidation both contribute to insulin resistance in diabetic subjects. OBJECTIVE In the present study, we investigated whether plasma adiponectin is associated with glucose oxidation and nonoxidative glucose disposal in subjects with and without type 2 diabetes. DESIGN Euglycemic-hyperinsulinemic clamp was performed in 42 type 2 diabetic (T2DM) and 13 nondiabetic (non-DM) subjects. The whole-body glucose disposal rate (GDR) was evaluated as the mean of the glucose infusion rate during steady state of the clamp. Glucose and fat oxidation rates were assessed by indirect calorimetry, and nonoxidative glucose disposal rate was calculated by subtracting glucose oxidation rate from GDR. RESULTS Plasma adiponectin level was significantly lower in T2DM than non-DM (2.87 +/- 1.40 vs. 3.96 +/- 2.39 microg/ml, P = 0.045). GDR (3.39 +/- 1.53 vs. 4.83 +/- 1.70 mg/kg x min, P = 0.006) and nonoxidative glucose disposal rate (1.89 +/- 1.39 vs. 3.11 +/- 1.76 mg/kg x min, P = 0.012) were significantly lower in T2DM, compared with non-DM, although no difference was found in glucose oxidation rate between the two groups. In all subjects, plasma adiponectin level was positively correlated with GDR (r = 0.351, P = 0.009) and nonoxidative glucose disposal rate (r = 0.324, P = 0.016) but not glucose oxidation rate. There was no significant correlation between plasma adiponectin level and fat oxidation, either before or during the clamp. CONCLUSIONS In conclusion, plasma adiponectin level is associated with nonoxidative glucose disposal, which is reduced in type 2 diabetic subjects. Our results suggest that adiponectin controls insulin sensitivity by modulating the glycogen synthetic process in human skeletal muscle.
Electronic reminder's role in promoting human papillomavirus vaccine use.

OBJECTIVES To study the association of using an electronic health record (EHR)'s clinical reminder functionality with increased human papillomavirus (HPV) vaccine administration among US office-based physicians. STUDY DESIGN National Ambulatory Medical Care Survey data from 2007-2012 were pooled together to determine if EHR systems that employ clinical reminders are associated with increased immunization rates in different populations. METHODS The administration of HPV vaccine served as the dependent variable, with the EHR reminder being the primary independent variable of interest. Logit regression was used to assess the relationship between using EHR reminders and HPV vaccine administration. RESULTS Analyses indicated that compared with physicians without clinical reminder functions, physicians with clinical reminder functions were more likely to order HPV vaccines. Clinical reminder functions were particularly effective at increasing HPV vaccine use among adolescent males. CONCLUSIONS Overall, physicians who report using clinical reminders were more likely to order HPV immunizations. However, the association of clinical reminders with HPV immunizations was not significant in the younger adolescent subpopulation. Further, given that HPV incidence decreases significantly even with small gains in vaccination rates, the increase in HPV immunizations found in the male population aged 11 to 21 years is promising. Therefore, targeting males to receive HPV vaccination immunizations through clinical reminders provides a positively disproportionate return on vaccination rates and disease burden.
Transnational forced migration and negotiating emotional well-being: the case of women refugees in South Africa

This study seeks to gain a better understanding of how a group of women refugees perceives their emotional well-being and how they make sense of their emotions. The discussion is based on a comparative qualitative study done in South Africa among Congolese, Burundian and Zimbabwean refugees. Attention is paid to intrapersonal emotional ambivalence and how the emotional well-being of refugees relates to their socio-economic context and more specifically their challenging life experiences. Reference is made to the role children and religion play in respondents’ perceived emotional well-being and hope for the future. In addition, all the respondents had to manage emotions related to transnational familial ties. On the one hand, an acute sense of family separation was experienced. On the other, respondents felt a sense of financial responsibility towards their kin who were left behind. Yet, few respondents had the means to provide family members with any form of financial assistance. This in turn had repercussions for their emotional well-being.
Local steroid injection via the cricothyroid membrane in patients with a vocal nodule.

OBJECTIVE To analyze the usefulness and safety of a steroid injection into vocal nodules via the cricothyroid membrane. Local administration of steroid directly into the larynx has been reported in many laryngeal diseases with different methods. DESIGN Prospective case series at an academic tertiary care hospital. PATIENTS Eighty patients with vocal nodules were enrolled between December 2008 and May 2010. INTERVENTIONS Triamcinolone acetonide was injected through the cricothyroid membrane with a transnasal flexible laryngoscope to patients in a sitting position. MAIN OUTCOME MEASURES Vocal nodules were evaluated before and 2 and 4 weeks after the injection; improvement was assessed both objectively and subjectively. RESULTS The nodules disappeared in 35 patients by the fourth week after the injection (44%), and 39 patients showed improvement (49%). Jitter, shimmer, maximum phonation time, and mean voice handicap index also improved significantly after the steroid injection (P < .05 for all). Six patients with voice-related occupations showed improvement at the second week (8%), but the nodules had recurred after 4 weeks. Four patients experienced mild vocal fold atrophy, and 2 patients showed a white plaque formation on the vocal fold that resolved spontaneously 1 to 2 months after the injection. CONCLUSIONS A local steroid injection via the cricothyroid membrane is a useful and safe treatment option for vocal nodules. However, vocal nodules are caused mainly by excessive voice use; therefore, nodules can recur unless the voice use pattern changes. Further study of this treatment technique, including long-term follow-up, is needed.