Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of Global Sagittal Postural Patterns in Asymptomatic Chinese Adults

Study Design A prospective imaging study. Purpose To characterize the distribution of the global sagittal postural patterns in asymptomatic Chinese adults using Roussouly classification. Overview of Literature The norms of sagittal parameters in asymptomatic Chinese population have been previously described, but no report described their global sagittal postural patterns as characterized by Roussouly classification. Methods A cohort of 272 asymptomatic Chinese adults was recruited. Data was assimilated by reviewing the films for each subject. Sagittal parameters were measured and sagittal postural patterns were then determined according to Roussouly classification. The pattern distributions were compared across genders within the study cohort. We also compared the data across different ethnicities from our study and a previous study to further characterize Chinese sagittal postures. Results The cohort included 161 males and 111 females, with mean age of 23.2±4.4 years. The average descriptive results were as below: pelvic incidence (PI) 46.4°±9.6°, thoracic kyphosis (TK) 24.2°±9.0°, lumbar lordosis (LL) 50.6°±10.6°, sacral slope (SS) 37.2°±7.6°, pelvic tilt (PT) 9.4°±6.8°, spinosacral angle (SSA) 131.1°±7.5° and sagittal vertical axis (SVA) 17.24±32.36 mm. Despite a significant difference between two genders in LL, PI, SSA, and SVA, no difference was found in the distribution of Roussouly types among them. 47.8% of our cohort belonged to Roussouly type 3, while type 1, 2 and 4 comprised 23.2%, 14.0% and 15.1% of the subjects, respectively. Roussouly classification was capable of categorizing sagittal parameters except for the PT. This study also found that 4.4% of the recruited subjects belonged to the C7-anterior subgroup. Conclusions From a characterization of the sagittal postural patterns of asymptomatic Chinese adults using Roussouly classification, the distribution was similar between Chinese males and females; however, from a cross-study comparison, it was different between asymptomatic Chinese and Caucasian adults, with a higher proportion of Roussouly type 3 in Chinese adults.
Lipid Rafts and Clathrin Cooperate in the Internalization of PrPC in Epithelial FRT Cells

Background The cellular prion protein (PrPC) plays a key role in the pathogenesis of Transmissible Spongiform Encephalopathies in which the protein undergoes post-translational conversion to the infectious form (PrPSc). Although endocytosis appears to be required for this conversion, the mechanism of PrPC internalization is still debated, as caveolae/raft- and clathrin-dependent processes have all been reported to be involved. Methodology/Principal Findings We have investigated the mechanism of PrPC endocytosis in Fischer Rat Thyroid (FRT) cells, which lack caveolin-1 (cav-1) and caveolae, and in FRT/cav-1 cells which form functional caveolae. We show that PrPC internalization requires activated Cdc-42 and is sensitive to cholesterol depletion but not to cav-1 expression suggesting a role for rafts but not for caveolae in PrPC endocytosis. PrPC internalization is also affected by knock down of clathrin and by the expression of dominant negative Eps15 and Dynamin 2 mutants, indicating the involvement of a clathrin-dependent pathway. Notably, PrPC co-immunoprecipitates with clathrin and remains associated with detergent-insoluble microdomains during internalization thus indicating that PrPC can enter the cell via multiple pathways and that rafts and clathrin cooperate in its internalization. Conclusions/Significance These findings are of particular interest if we consider that the internalization route/s undertaken by PrPC can be crucial for the ability of different prion strains to infect and to replicate in different cell lines.
Lipoprotein Autoantibodies

Two decades ago, well before the inflammatory nature of arteriosclerosis was generally accepted, several groups reported the finding of immunoglobulins and various complement components in atheromatous plaques of humans and rabbits ([12][1], [42][2], [69][3]). A decade later apolipoprotein B (ApoB)
A naturalistic approach to assessing hearing aid candidacy and motivating hearing aid use.

BACKGROUND Although the benefits of amplification for persons with impaired hearing are well established, many potential candidates do not obtain and use hearing aids. In some cases, this is because the individual is not convinced that amplification will be of sufficient benefit in those everyday listening situations where he or she is experiencing difficulties. PURPOSE To describe the development of a naturalistic approach to assessing hearing aid candidacy and motivating hearing aid use based on patient preferences for unamplified and amplified sound samples typical of those encountered in everyday living and to assess the validity of these preference ratings to predict hearing aid candidacy. RESEARCH DESIGN Prospective experimental study comparing preference ratings for unamplified and amplified sound samples of patients with a clinical recommendation for hearing aid use and patients for whom amplification was not prescribed. STUDY SAMPLE Forty-eight adults self-referred to the Army Audiology and Speech Center for a hearing evaluation. DATA COLLECTION AND ANALYSIS Unamplified and amplified sound samples were presented to potential hearing aid candidates using a three-alternative forced-choice paradigm. Participants were free to switch at will among the three processing options (no gain, mild gain, moderate gain) until the preferred option was determined. Following this task, each participant was seen for a diagnostic hearing evaluation by one of eight staff audiologists with no knowledge of the preference data. Patient preferences for the three processing options were used to predict the attending audiologists' recommendations for amplification based on traditional audiometric measures. RESULTS Hearing aid candidacy was predicted with moderate accuracy from the patients' preferences for amplified sounds typical of those encountered in everyday living, although the predictive validity of the various sound samples varied widely. CONCLUSIONS Preferences for amplified sounds were generally predictive of hearing aid candidacy. However, the predictive validity of the preference ratings was not sufficient to replace traditional clinical determinations of hearing aid candidacy in individual patients. Because the sound samples are common to patients' everyday listening experiences, they provide a quick and intuitive method of demonstrating the potential benefit of amplification to patients who might otherwise not accept a prescription for hearing aids.
Object Worlds in Work Domain Analysis: A Model of Naval Damage Control

This paper presents a work domain analysis of damage control on the Canadian Halifax Class frigate. Our analysis made use of the modeling construct of object worlds to help in defining the work domain to model and to help in understanding the results of this model compared to other work domain analyses developed in the naval domain. This paper makes a practical contribution through the presentation of a detailed example of work domain analysis in a new domain and a theoretical contribution by clarifying the use of object worlds in work domain analysis, analyzing the way in which object worlds can be understood in systems where the various stakeholders are closely coordinated and promoting object worlds as a way to control model scope.
Hierarchical, perceptron-like learning for ontology-based information extraction

Recent work on ontology-based Information Extraction (IE) has tried to make use of knowledge from the target ontology in order to improve semantic annotation results. However, very few approaches exploit the ontology structure itself, and those that do so, have some limitations. This paper introduces a hierarchical learning approach for IE, which uses the target ontology as an essential part of the extraction process, by taking into account the relations between concepts. The approach is evaluated on the largest available semantically annotated corpus. The results demonstrate clearly the benefits of using knowledge from the ontology as input to the information extraction process. We also demonstrate the advantages of our approach over other state-of-the-art learning systems on a commonly used benchmark dataset.
The constructal law of design and evolution in nature

Constructal theory is the view that (i) the generation of images of design (pattern, rhythm) in nature is a phenomenon of physics and (ii) this phenomenon is covered by a principle (the constructal law): ‘for a finite-size flow system to persist in time (to live) it must evolve such that it provides greater and greater access to the currents that flow through it’. This law is about the necessity of design to occur, and about the time direction of the phenomenon: the tape of the design evolution ‘movie’ runs such that existing configurations are replaced by globally easier flowing configurations. The constructal law has two useful sides: the prediction of natural phenomena and the strategic engineering of novel architectures, based on the constructal law, i.e. not by mimicking nature. We show that the emergence of scaling laws in inanimate (geophysical) flow systems is the same phenomenon as the emergence of allometric laws in animate (biological) flow systems. Examples are lung design, animal locomotion, vegetation, river basins, turbulent flow structure, self-lubrication and natural multi-scale porous media. This article outlines the place of the constructal law as a self-standing law in physics, which covers all the ad hoc (and contradictory) statements of optimality such as minimum entropy generation, maximum entropy generation, minimum flow resistance, maximum flow resistance, minimum time, minimum weight, uniform maximum stresses and characteristic organ sizes. Nature is configured to flow and move as a conglomerate of ‘engine and brake’ designs.
Winkball for Schools: An Advanced Video Modelling Technology for Learning Visual and Oral Communication Skills

The tracks analysis concerning students' actions logged by Technology Enhanced Learning systems can help teacher to improve their pedagogical scenarios making them relevant to students. Besides, sharing and reusing teachers' know-how and experience in the session analysis of learning systems also facilitate their scenario enhancement. In this paper, we present our proposal for obtaining these goals. We first describe the calculation method of pedagogical indicators from the tracks collected using the Usage Tracking Language and Data Combination Language. Then, we present our developed tool which allows executing these indicators. We also present results which validate our proposal with the tracks from the real learning environment. Our approach can be used to support engineering and re-engineering of pedagogical scenarios in Technology Enhanced Learning systems.
Can Selectional Preferences Help Automatic Semantic Role Labeling?

We describe a topic model based approach for selectional preference. Using the topic features generated by an LDA model on the extracted predicate-arguments over the Chinese Gigaword corpus, we show improvement to our state-of-the-art Chinese SRL system by 2.34 F1 points on arguments of nominal predicates, 0.40 F1 point on arguments of verb predicates, and 0.66 F1 point overall. More over, similar gains were achieved on out-ofgenre test data, as well as on English SRL using the same technique.
The gene for Stargardt disease, ABCA4, is a major retinal gene: a mini-review

The gene ABCA 4 encodes the rod and cone photoreceptor Rim protein, which is a transmembrane transporter of vitamin A intermediates. ABCA 4 mutations are responsible for a large variety of retinal degenerations including all cases of Stargardt macular dystrophy and fundus flavimaculatus, some forms of cone-rod degeneration, and retinitis pigmentosa, and likely increase the risk of developing agerelated macular degeneration (AMD). The purpose of this mini-review is to highlight the advances in our understanding of Stargardt disease and the ABCA 4 gene from the first description of the disease by Karl Stargardt in 1909 to gene discovery by Allikmets and colleagues in 1997. The knockout mouse model by Mata and co-workers has provided crucial pathophysiological information that has led to new ideas regarding treatment possibilities. These hypotheses were tested by Radu and colleagues in the mouse and shown to be efficacious.
A Deep Convolutional Coupling Network for Change Detection Based on Heterogeneous Optical and Radar Images

We propose an unsupervised deep convolutional coupling network for change detection based on two heterogeneous images acquired by optical sensors and radars on different dates. Most existing change detection methods are based on homogeneous images. Due to the complementary properties of optical and radar sensors, there is an increasing interest in change detection based on heterogeneous images. The proposed network is symmetric with each side consisting of one convolutional layer and several coupling layers. The two input images connected with the two sides of the network, respectively, are transformed into a feature space where their feature representations become more consistent. In this feature space, the different map is calculated, which then leads to the ultimate detection map by applying a thresholding algorithm. The network parameters are learned by optimizing a coupling function. The learning process is unsupervised, which is different from most existing change detection methods based on heterogeneous images. Experimental results on both homogenous and heterogeneous images demonstrate the promising performance of the proposed network compared with several existing approaches.
Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome

The Dengue virus (DENV) genome contains multiple cis-acting elements required for translation and replication. Previous studies indicated that a 719-nt subgenomic minigenome (DENV-MINI) is an efficient template for translation and (−) strand RNA synthesis in vitro. We performed a detailed structural analysis of DENV-MINI RNA, combining chemical acylation techniques, Pb2+ ion-induced hydrolysis and site-directed mutagenesis. Our results highlight protein-independent 5′–3′ terminal interactions involving hybridization between recognized cis-acting motifs. Probing analyses identified tandem dumbbell structures (DBs) within the 3′ terminus spaced by single-stranded regions, internal loops and hairpins with embedded GNRA-like motifs. Analysis of conserved motifs and top loops (TLs) of these dumbbells, and their proposed interactions with downstream pseudoknot (PK) regions, predicted an H-type pseudoknot involving TL1 of the 5′ DB and the complementary region, PK2. As disrupting the TL1/PK2 interaction, via ‘flipping’ mutations of PK2, previously attenuated DENV replication, this pseudoknot may participate in regulation of RNA synthesis. Computer modeling implied that this motif might function as autonomous structural/regulatory element. In addition, our studies targeting elements of the 3′ DB and its complementary region PK1 indicated that communication between 5′–3′ terminal regions strongly depends on structure and sequence composition of the 5′ cyclization region.
Mechanisms for Differential Protein Production in Toxin–Antitoxin Systems

Toxin–antitoxin (TA) systems are key regulators of bacterial persistence, a multidrug-tolerant state found in bacterial species that is a major contributing factor to the growing human health crisis of antibiotic resistance. Type II TA systems consist of two proteins, a toxin and an antitoxin; the toxin is neutralized when they form a complex. The ratio of antitoxin to toxin is significantly greater than 1.0 in the susceptible population (non-persister state), but this ratio is expected to become smaller during persistence. Analysis of multiple datasets (RNA-seq, ribosome profiling) and results from translation initiation rate calculators reveal multiple mechanisms that ensure a high antitoxin-to-toxin ratio in the non-persister state. The regulation mechanisms include both translational and transcriptional regulation. We classified E. coli type II TA systems into four distinct classes based on the mechanism of differential protein production between toxin and antitoxin. We find that the most common regulation mechanism is translational regulation. This classification scheme further refines our understanding of one of the fundamental mechanisms underlying bacterial persistence, especially regarding maintenance of the antitoxin-to-toxin ratio.
Silencing Prion Protein in MDA-MB-435 Breast Cancer Cells Leads to Pleiotropic Cellular Responses to Cytotoxic Stimuli

Prion protein (PrP) is well studied for its pathogenic role in prion disease, but its potential contribution to other pathological processes is less understood. PrP is expressed in a variety of cancers and at least in pancreatic and breast cancers, its expression appears to be associated with poor prognosis. To understand the role of PrP in breast cancer cells, we knocked down PrP expression in MDA-MB-435 breast cancer cells with small interfering RNA and subjected these cells to a series of analyses. We found that PrP knockdown in these cells does not affect cell proliferation or colony formation, but significantly influences the cellular response to cytotoxic stimuli. Compared to control cells, PrP knockdown cells exhibited an increased susceptibility to serum deprivation induced apoptosis, no change to staurosporine- or paclitaxel-induced cell deaths, and a reduced susceptibility to chemotherapy drug doxorubicin-induced cell death. To understand the mechanism of unexpected role of PrP in exacerbating doxorubicin-induced cytotoxicity, we analyzed cell death related Bcl-2 family proteins. We found that PrP knockdown alters the expression of several Bcl-2 family proteins, correlating with increased resistance to doxorubicin-induced cytotoxicity. Moreover, the enhanced doxorubicin resistance is independent of DNA damage related p53 pathway, but at least partially through the ERK1/2 pathway. Together, our study revealed that silencing PrP in MDA-MB-435 breast cancer cells results in very different responses to various cytotoxic stimuli and ERK1/2 signaling pathway is involved in PrP silencing caused resistance to doxorubicin.
Online Phase Detection Using Wearable Sensors for Walking with a Robotic Prosthesis

This paper presents a gait phase detection algorithm for providing feedback in walking with a robotic prosthesis. The algorithm utilizes the output signals of a wearable wireless sensory system incorporating sensorized shoe insoles and inertial measurement units attached to body segments. The principle of detecting transitions between gait phases is based on heuristic threshold rules, dividing a steady-state walking stride into four phases. For the evaluation of the algorithm, experiments with three amputees, walking with the robotic prosthesis and wearable sensors, were performed. Results show a high rate of successful detection for all four phases (the average success rate across all subjects >90%). A comparison of the proposed method to an off-line trained algorithm using hidden Markov models reveals a similar performance achieved without the need for learning dataset acquisition and previous model training.
Dose-dependent progression of parkinsonism in manganese-exposed welders

Objective: To determine whether the parkinsonian phenotype prevalent in welders is progressive, and whether progression is related to degree of exposure to manganese (Mn)-containing welding fume. Methods: This was a trade union–based longitudinal cohort study of 886 American welding-exposed workers with 1,492 examinations by a movement disorders specialist, including 398 workers with 606 follow-up examinations up to 9.9 years after baseline. We performed linear mixed model regression with cumulative Mn exposure as the independent variable and annual change in Unified Parkinson Disease Rating Scale motor subsection part 3 (UPDRS3) as the primary outcome, and subcategories of the UPDRS3 as secondary outcomes. The primary exposure metric was cumulative Mn exposure in mg Mn/m3-year estimated from detailed work histories. Results: Progression of parkinsonism increased with cumulative Mn exposure. Specifically, we observed an annual change in UPDRS3 of 0.24 (95% confidence interval 0.10–0.38) for each mg Mn/m3-year of exposure. Exposure was most strongly associated with progression of upper limb bradykinesia, upper and lower limb rigidity, and impairment of speech and facial expression. The association between welding exposure and progression appeared particularly marked in welders who did flux core arc welding in a confined space or workers whose baseline examination was within 5 years of first welding exposure. Conclusions: Exposure to Mn-containing welding fume may cause a dose-dependent progression of parkinsonism, especially upper limb bradykinesia, limb rigidity, and impairment of speech and facial expression.
Bait Preference of Free-Ranging Feral Swine for Delivery of a Novel Toxicant

Invasive feral swine (Sus scrofa) cause extensive damage to agricultural and wildlife resources throughout the United States. Development of sodium nitrite as a new, orally delivered toxicant is underway to provide an additional tool to curtail growth and expansion of feral swine populations. A micro-encapsulation coating around sodium nitrite is used to minimize detection by feral swine and maximize stability for the reactive molecule. To maximize uptake of this toxicant by feral swine, development a bait matrix is needed to 1) protect the micro-encapsulation coating so that sodium nitrite remains undetectable to feral swine, 2) achieve a high degree of acceptance by feral swine, and 3) be minimally appealing to non-target species. With these purposes, a field evaluation at 88 sites in south-central Texas was conducted using remote cameras to evaluate preferences by feral swine for several oil-based bait matrices including uncolored peanut paste, black-colored peanut paste, and peanut-based slurry mixed onto whole-kernel corn. These placebo baits were compared to a reference food, whole-kernel corn, known to be readily taken by feral swine (i.e., control). The amount of bait consumed by feral swine was also estimated using remote cameras and grid boards at 5 additional sites. On initial exposure, feral swine showed reduced visitations to the uncolored peanut paste and peanut slurry treatments. This reduced visitation subsided by the end of the treatment period, suggesting that feral swine needed time to accept these bait types. The black-colored peanut paste was visited equally to the control throughout the study, and enough of this matrix was consumed to deliver lethal doses of micro-encapsulated sodium nitrite to most feral swine during 1–2 feeding events. None of the treatment matrices reduced visitations by nontarget species, but feral swine dominated visitations for all matrices. It was concluded that black-colored peanut paste achieved satisfactory preference and consumption by feral swine, and no discernable preference by non-target species, compared to the other treatments.