Miracle-dz/UniFAR-FTUs huggingface dataset:
The Golgi Association of Endothelial Nitric Oxide Synthase Is Necessary for the Efficient Synthesis of Nitric Oxide(*)

The particulate enzyme, endothelial nitric oxide synthase (eNOS), produces nitric oxide to maintain normal vasodilator tone in blood vessels. In this study, we demonstrate that eNOS is a Golgi-associated protein in cultured endothelial cells and intact blood vessels. Using a heterologous expression system in HEK 293 cells, we show that wild-type myristoylated and palmitoylated eNOS, but not mutant, non-acylated eNOS targets to the Golgi. More importantly, HEK 293 cells expressing wild-type eNOS release substantially more NO than cells expressing the mutant, non-acylated enzyme. Thus, eNOS is a novel Golgi-associated protein, and Golgi compartmentalization is necessary for the enzyme to respond to intracellular signals and produce NO.
Causal ordering of stress, satisfaction and commitment, and intention to quit: a structural equations analysis

This study addresses the confusion prevailing over the nature of the relationship between satisfaction and commitment in regard to employee turnover, and examines the causal pattern of relationships among stress, satisfaction, commitment, and turnover intentions by employing a structural equations analysis approach. The results indicate that there are strong causal links between stress and satisfaction (higher stress leads to lower satisfaction) and between satisfaction and commitment (lower satisfaction leads to lower commitment), and a reciprocal relationship between commitment and turnover intentions (lower commitment leads to greater intentions to quit which, in turn, further lowers commitment).
Marriage matching, risk sharing and spousal labor supplies

This paper develops the collective marriage matching model, a behavioral and empirically ‡exible framework that incorporates both marriage matching and intrahousehold allocations. The model shows how marriage market equilibrium and bargaining power within the family are simultaneously determined. The framework provides a solution to the problem of incorporating substitute sex ratios in empirical models of spousal labor supplies. Using data from the US 2000 census, the empirical results show that changes in marriage market tightness, the ratio of unmarried men to unmarried women, have large estimated =
Loopo: a tangible programming game for kids

This project explores a method to incorporate computer programming into primary school education. Through researching into effective teaching methods and combining it with inspirations taken from existing educational computer programming projects, we developed Loopo. Loopo blends a specially designed tangible interface with a digital interface. The tangibility of Loopo encourages collaboration among the users and motivates them to learn together. To keep up with the increasingly earlier adoption of computer technology, Loopo's goal is to teach children the fundamentals of computer programming in a fun, relatable, and interesting way, while nurturing collaboration through an easily approachable system.
Capturing Landscape Visual Character Using Indicators: Touching Base with Landscape Aesthetic Theory

Abstract This paper presents one way that landscape visual character can be captured using indicators derived from nine theory-based concepts related to landscape perception. The paper aims to establish links between landscape aesthetic theory and visual indicators, thus exploring what landscape indicators are really indicating. The steps from abstract visual concepts to measurable visual indicators are described, and links are made to theories of landscape preferences and perception. The focus of the paper is on the application of indicators, including a presentation of the possible data sources of the presented indicators. The paper includes a discussion on the selection of appropriate landscape indicators through a suggested filtering process. The relationships between the concepts and the ability of visual indicators to capture changes in landscape character and other issues related to interpretation are discussed.
A Simplified Behavioral MOSFET Model Based on Parameters Extraction for Circuit Simulations

This paper presents results on behavior modeling of a general purpose metal-oxide-semiconductor field-effect transistor (MOSFET) for simulation of power electronics systems requiring accuracy both in steady state and in switching conditions. Methods of parameters extraction, including nonlinearity of parasitic capacitances and steady-state characteristics, are based on manufacturer datasheet and externally measurable characteristics. The MOSFET template is written in the MAST language and simulated in the SABER simulator. Experimental validation of the N-channel power MOSFET-type IRFP240 (Fairchild Semiconductor) rated at 20 A/200 V is performed in a dc/dc boost converter. The main features of the developed model have been compared with the properties of an analytical MOSFET model and a general MOSFET model embedded to a SABER simulator.
Understanding Urban Models versus Understanding Cities

The relationship between theory and practice in regional science is examined in terms of the use of urban modelling as a ‘policy science’ in the service of planning. It is argued that through this relationship, the theoretical deficiencies of models are reinforced by deficiencies in the way planning institutions are able to define practical problems for the ‘policy scientist’ to solve.
HFR1 Sequesters PIF1 to Govern the Transcriptional Network Underlying Light-Initiated Seed Germination in Arabidopsis[C][W][OPEN]

This study identifies the LONG HYPOCOTYL IN FAR-RED1 (HFR1)– PHYTOCHROME-INTERACTING FACTOR 1 (PIF1) pair as the central transcriptional regulatory module for rapid light-initiated transcriptome changes in imbibed seeds. HFR1 interacts with PIF1 to prevent PIF1 from binding to DNA, promoting light-initiated germination. The functionally antagonistic HFR1–PIF1 pair constructs a fail-safe mechanism for fine-tuning seed germination under low-level illumination. Seed germination is the first step for seed plants to initiate a new life cycle. Light plays a predominant role in promoting seed germination, where the initial phase is mediated by photoreceptor phytochrome B (phyB). Previous studies showed that PHYTOCHROME-INTERACTING FACTOR1 (PIF1) represses seed germination downstream of phyB. Here, we identify a positive regulator of phyB-dependent seed germination, LONG HYPOCOTYL IN FAR-RED1 (HFR1). HFR1 blocks PIF1 transcriptional activity by forming a heterodimer with PIF1 that prevents PIF1 from binding to DNA. Our whole-genomic analysis shows that HFR1 and PIF1 oppositely mediate the light-regulated transcriptome in imbibed seeds. Through the HFR1–PIF1 module, light regulates expression of numerous genes involved in cell wall loosening, cell division, and hormone pathways to initiate seed germination. The functionally antagonistic HFR1–PIF1 pair constructs a fail-safe mechanism for fine-tuning seed germination during low-level illumination, ensuring a rapid response to favorable environmental changes. This study identifies the HFR1–PIF1 pair as a central module directing the whole genomic transcriptional network to rapidly initiate light-induced seed germination.
Social Cognition and Writing

This study examines the relationship between two measures of individual differences in social cognition and the quality of eleventh grade students' persuasive writing. Subjects completed Crockett's Role Category Questionnaire, and wrote a persuasive letter in response to the problem, “Smoking and the School Nurse. ” Letters were submitted to judges for impressionistic and attributional ratings. A content-analytic measure was applied to these 40 papers to yield a measure of the number and quality of persuasive strategies employed. Finally, the same papers were submitted to a second panel, who rated them for overall persuasiveness and appropriateness of tone. Results indicated a significant relationship between interpersonal cognitive complexity and abstractness and quality of writing, persuasiveness, appropriateness of tone, and level of persuasive strategy employed.
Theory and analysis of differentially-driven microstrip antennas

This paper studies differentially-driven microstrip antennas. The theory of microstrip antennas based on the improved cavity model is expanded to analyze the input impedance and radiation characteristics of the differentially-driven microstrip antennas. The differentially-driven microstrip antennas were fabricated. Their performances were experimentally verified. Results show that the occurrence of resonance for the differentially-driven microstrip antennas also depends on the ratio of the separation /spl xi/ of the dual feeds to the free-space wavelength /spl lambda//sub o/. When the dual feeds are located far from each other /spl xi///spl lambda//sub o/>0.1, the resonance occurs, and the input resistance at resonance is rather large. However, when the dual feeds are located near to each other /spl xi///spl lambda//sub o/<0.1, the resonance does not occur, the input resistance is quite small, and the input impedance is inductive. Compared with single-ended microstrip antennas, the differentially-driven microstrip antennas have larger resonant resistance, similar co-polar radiation patterns, and lower cross-polar radiation component.
Understanding the Complexity of Human Aggression: Affective, Cognitive, and Social Dimensions of Individual Differences in Propensity Toward Aggression

Human aggression is a complex phenomenon operating at multiple levels. Converging evidence distinguishes ‘hot’ aggression, impulsive and emotionally‐centered, from ‘cool’ aggression, cognitively based and instrumental. The correspondence of these aggressive response patterns with individual differences in Propensity toward Aggression was investigated. Our data (from 477 Italian adults) map ten of these aggression indicators into the personality space defined by the Five‐Factor Model (FFM) of personality. The quadrant containing most of these variables is defined by Emotional Instability (the negative pole of Emotional Stability) and Hostility (the negative pole of Friendliness). Factor analysis uncovered two factors that accounted for nearly 60 percent of the variance in Propensity toward Aggression: Emotional Responsivity and Positive Evaluation of Violence. Practical implications for issues of health and disease, violence, and interventions for different forms of adults' and children's aggression are outlined.
Family Placement Schemes for Adult Persons with Intellectual Disabilities Living with Elderly Carers

Few family placement schemes involve adult persons, and rarely have they been targeted at older carers. Twenty-five carers, aged 55 years and over, of people with intellectual disabilities using one of two placement schemes in Northern Ireland were studied, along with a further 20 carers recommended for these schemes. Semi-structured individual interviews were used to obtain the views of carers, people with intellectual disabilities and placement providers. The placement schemes were very favourably received. Carers welcomed the break and valued the relationship with the placement provider. Individuals with disability reported greater opportunities to participate in activities. Placement providers were very satisfied with the way the schemes operated: the main complaint was the low level of payments. Key factors affecting the further development of services include recruitment of male providers, registration issues, training of providers and the difficulty in meeting the needs of multiply disabled persons.
Implications of diabetes mellitus in patients with STEMI: data from Thai ACS Registry.

BACKGROUND Data exist on the community-based perspective on the relation of diabetes mellitus (DM) and acute ST elevation myocardial infarction (STEMI) worldwide but no data is available in Thailand. MATERIAL AND METHOD The Thai Acute Coronary Syndrome Registry (TACSR) is an observational study of patients hospitalized with ACS at 17 hospitals in different regions of Thailand. The present sub-study sample consisted of 3,725 patients with STEMI in a 3-year period. RESULTS Nearly 40% (37.15%) of them had DM who were older predominantly women, with a greater prevalence of co-morbidities and fewer current smokers. Patients with DM who developed STEMI were at increased risk for heart failure, arrhythmia, bleeding and death. These differences remained after adjustment for potential confounding prognostic factors. CONCLUSION A considerable proportion of patients with STEMI have DM. This proportion is higher than any other studies published. Diabetic patients who developed STEMI are also at increased risk for adverse outcomes including, heart failure, arrhythmia, bleeding and death compared to patients without DM.
Patterns and Perceptions of Climate Change in a Biodiversity Conservation Hotspot

Quantifying local people's perceptions to climate change, and their assessments of which changes matter, is fundamental to addressing the dual challenge of land conservation and poverty alleviation in densely populated tropical regions To develop appropriate policies and responses, it will be important not only to anticipate the nature of expected changes, but also how they are perceived, interpreted and adapted to by local residents. The Albertine Rift region in East Africa is one of the world's most threatened biodiversity hotspots due to dense smallholder agriculture, high levels of land and resource pressures, and habitat loss and conversion. Results of three separate household surveys conducted in the vicinity of Kibale National Park during the late 2000s indicate that farmers are concerned with variable precipitation. Many survey respondents reported that conditions are drier and rainfall timing is becoming less predictable. Analysis of daily rainfall data for the climate normal period 1981 to 2010 indicates that total rainfall both within and across seasons has not changed significantly, although the timing and transitions of seasons has been highly variable. Results of rainfall data analysis also indicate significant changes in the intra-seasonal rainfall distribution, including longer dry periods within rainy seasons, which may contribute to the perceived decrease in rainfall and can compromise food security. Our results highlight the need for fine-scale climate information to assist agro-ecological communities in developing effective adaptive management.
High Q active inductors apply in a 2.4GHz bandpass filter

In this paper, we investigate high Q (quality factor) active inductors to apply in a 2.4GHz bandpass filter design with 0. 18µm CMOS process integrated into the system-on-chip (SoC) concept. Simulation results show the bandpass filter circuit obtaining good performance, such as input return loss (S11) of -34.703dB, output return loss (S22) of -34.315dB, loss (S21) of -0.213dB, noise figure (NF) of 10.156dB, 1-dB compression point (P1dB) of 3dBm, third-order intercept point (IIP3) of -3.151dBm, and 1.872mW power dissipation under 1.8V power-supply. The dimension of this circuit occupyes approximate to 450×390 µm2.
Eviction’s Fallout: Housing, Hardship, and Health

Millions of families across the United States are evicted each year. Yet, we know next to nothing about the impact eviction has on their lives. Focusing on low-income urban mothers, a population at high risk of eviction, this study is among the first to examine rigorously the consequences of involuntary displacement from housing. Applying two methods of propensity score analyses to data from a national survey, we find that eviction has negative effects on mothers in multiple domains. Compared to matched mothers who were not evicted, mothers who were evicted in the previous year experienced more material hardship, were more likely to suffer from depression, reported worse health for themselves and their children, and reported more parenting stress. Some evidence suggests that at least two years after their eviction, mothers still experienced significantly higher rates of material hardship and depression than peers.
The Role of Semantic Interference in Limiting Memory for the Details of Visual Scenes

Many studies suggest a large capacity memory for briefly presented pictures of whole scenes. At the same time, visual working memory (WM) of scene elements is limited to only a few items. We examined the role of retroactive interference in limiting memory for visual details. Participants viewed a scene for 5 s and then, after a short delay containing either a blank screen or 10 distracter scenes, answered questions about the location, color, and identity of objects in the scene. We found that the influence of the distracters depended on whether they were from a similar semantic domain, such as “kitchen” or “airport. ” Increasing the number of similar scenes reduced, and eventually eliminated, memory for scene details. Although scene memory was firmly established over the initial study period, this memory was fragile and susceptible to interference. This may help to explain the discrepancy in the literature between studies showing limited visual WM and those showing a large capacity memory for scenes.
General self-efficacy and self-esteem: toward theoretical and empirical distinction between correlated self-evaluations

To test whether general self-efficacy and self-esteem relate differently to motivational and affective constructs, we collected data from samples in academic and work settings. Results suggest that general self-efficacy is more highly related to motivational variables than is self-esteem, whereas self-esteem is more highly related to affective variables than is general self-efficacy, as hypothesized. Furthermore, results support the notion that motivational and affective states differentially mediate the relationships of general self-efficacy and self-esteem with task performance. These results confirm the theoretical distinction between general self-efficacy and self-esteem and suggest that failure to distinguish between them might exact a price in terms of precision, validity, and understanding of determinants of performance. Implications for research and practice in organizations are discussed. Copyright © 2004 John Wiley & Sons, Ltd.
STRICTLY SEMI-TRANSITIVE OPERATOR ALGEBRAS

An algebra A of operators on a Banach space X is called strictly semi- transitive if for all non-zero x,y 2 X there exists an operator A 2 A such that Ax = y or Ay = x. We show that if A is norm-closed and strictly semi-transitive, then every A-invariant linear subspace is norm-closed. Moreover, LatA is totally and well ordered by reverse inclusion. If X is complex and A is transitive and strictly semi- transitive, then A is WOT-dense in L(X). It is also shown that if A is an operator algebra on a complex Banach space with no invariant operator ranges, then A is WOT-dense in L(X). This generalizes a similar result for Hilbert spaces proved by Foias.
Testing the ‘Residential Rootedness’ Hypothesis of Self-Employment for Germany and the UK

Based on the notion that entrepreneurship is a ‘local event’, the literature argues that entrepreneurs are ‘rooted’ in place. This paper tests the ‘residential rootedness’ hypothesis of self-employment by examining for Germany and the UK whether the self-employed are less likely to move over long distances (internal migration) than workers in paid employment. Using longitudinal data from the German Socio-Economic Panel Study (SOEP) and the British Household Panel Survey (BHPS), and accounting for transitions in employment status we found little evidence that the self-employed in Germany and the UK are more rooted in place than workers in paid employment. Generally speaking, the self-employed were no less likely than workers in paid employment to migrate over longer distance. In contrast to the residential rootedness hypothesis we found that entry into self-employment and female self-employment are associated with internal migration, and that the self-employed who work from home (home-based businesses) are fairly geographically mobile. The gendered results suggest that women might use self-employment as a strategy to be spatially mobile with their household, or as a strategy to stay in the workforce after having moved residence until they find a job in the more secure wage and salary sector.
Expression profiling and local adaptation of Boechera holboellii populations for water use efficiency across a naturally occurring water stress gradient

We studied the physiological basis of local adaptation to drought in Boechera holboellii, a perennial relative of Arabidopsis thaliana, and used cDNA–AFLPs to identify candidate genes showing differential expression in these populations. We compared two populations of B. holboellii from contrasting water environments in a reciprocal transplant experiment, as well as in a laboratory dry‐down experiment. We continuously measured the water content of soils using time domain reflectometery (TDR). We compared populations for their water use efficiency (WUE), root/shoot ratios (R:S) and leaf mass per unit area (LMA) in the field and in the laboratory, and identified candidate genes that (i) responded plastically to water stress and (ii) were differentially expressed between the two populations. Genotypes from the drier site had higher WUE, which was attributable to a large reduction in transpirational water loss. The xeric‐adapted population also had increased investment in root biomass and greater leaf mass per unit area. Reciprocal transplants in the field had significantly greater survival in their native habitat. In total, 450 cDNA‐AFLP fragments showed significant changes between drought and control treatments. Furthermore, some genes showed genotype (population)‐specific patterns of up‐ or down‐regulation in response to drought. Three hundred cDNA‐AFLP bands were sequenced leading to the identification of cDNAs coding for proteins involved in signal transduction, transcriptional regulation, redox regulation, oxidative stress and pathways involved in stress adaptation. Some of these proteins could contribute a physiological advantage under drought, making them potential targets for natural selection.
Cellular therapy to treat haematological and other malignancies: progress and pitfalls

Summary The recent Food and Drug Administration (FDA) approval of a cellular therapy to treat castration resistant prostate cancer has reinforced the potential of cellular therapy to consolidate current pharmacological approaches to treating cancer. The emergence of the cell manufacturing facility to facilitate clinical translation of these new methodologies allows greater access to these novel therapies. Here we review different strategies currently being explored to treat haematological malignancies with a focus on adoptive allogeneic or autologous transfer of antigen specific T cells, NK cells or dendritic cells. These approaches all aim to generate immunological responses against overexpressed tissue antigens, mismatched minor histocompatability antigens or tumour associated antigens. Current successes and limitations of these different approaches will be discussed with an emphasis on challenges encountered in generating long term engraftment, antigen selection and implementation as well as therapeutic immune monitoring of clinical responses, with examples from recent clinical trials.
Antibodies to herpes group viruses in patients with nasopharyngeal and other head and neck cancers.

Elevated Epstein-Barr virus antibody titers were found in cases of nasopharyngeal carcinoma in all racial and ethnic groups tested. Titers were highest in patients with active, advanced disease. Antibody titers to other herpesviruses were not increased above controls. Elevated EBV titers were found also in patients with epidermoid cancer of the nasal cavity and hypopharynx.