Miracle-dz/UniFAR-FTUs huggingface dataset:
By Ultrasonic-Guided Erector Spinae Block, Thoracic Paravertebral Block versus Serratus Anterior Plane Block by Articaine with Adrenaline during Breast Surgery with General Anesthesia: A Comparative Study of Analgesic Effect Post-Operatively: Double Blind Randomized, Controlled Trial

Background and Aims: Erector spinae plane block, Paravertebral block and serratus anterior block are three formats for analgesia post-operatively following radical mastectomy. This study compares the analgesic efficacy of these modalities for analgesia post-operatively by articaine 2% with adrenaline. Methods: Seventy-five patients with ASA physical status I or II subjected to modified radical mastectomy with axillary clearance were enrolled for the study. After induction of general anaesthesia all patients received 20 mL 2% articaine with adrenaline in each technique of the study. Patients in Group 1 (Erector spinae block [ESB], n = 25), Group 2 paravertebral block [PVB] n = 25), Group 3 (serratus anterior plane block [SAPB] n = 25) were ultrasound-guided on ipsilateral side. Patients were estimated for pain scores at 0, 2, 4, 6, 12 and 24 h, and duration of analgesia post-operatively and relieve analgesic doses required of morphine up to 24 h. Results: Visual analogue scale scores post-operatively were lower in ESB and PVB group compared with SAPB at 4, 6, 12 and 24 h (P < 0.05). The first analgesic dose requirement was significantly longer in ESB (416 ± 68 min) than PVB group (371 ± 67 min) in compared with SAPB (343.5 ± 54.7 min). Mean duration of analgesia was significantly longer in ESB and PVB group (P < 0.001) in compared with SAPB. Total morphine dose of relieving analgesic was significantly lesser in ESB (4 ± 2 mg) than PVB group (6 ± 2 mg) compared with SAPB (7 ± 2 mg) up to 24 h. ESB was easy technique and has less side effect on compared with PVB. As regard block-related complications including (accidental vascular puncture, pneumothorax, nerve damage, local anesthetics toxicity), there were no significant adverse effects noted in three groups. However, only a case of pneumothorax in (PVB) and a two patients’ blood was aspirated when the paravertebral space was entered which required second trial at the blocks. Conclusion: Sonar-guided erector spinae block and thoracic paravertebral block minimize post-operative pain scores, prolongs the duration of analgesia and diminishes requirements for assigning analgesics in the first 24 h of post-operative period compared to ultrasound-guided serratus anterior plane block but, ESB technique was more potent, easily and less side effect in compared with PVB.
Evolutionary Analysis of MIKCc-Type MADS-Box Genes in Gymnosperms and Angiosperms

MIKCc-type MADS-box genes encode transcription factors that control floral organ morphogenesis and flowering time in flowering plants. Here, in order to determine when the subfamilies of MIKCc originated and their early evolutionary trajectory, we sampled and analyzed the genomes and large-scale transcriptomes representing all the orders of gymnosperms and basal angiosperms. Through phylogenetic inference, the MIKCc-type MADS-box genes were subdivided into 14 monophyletic clades. Among them, the gymnosperm orthologs of AGL6, SEP, AP1, GMADS, SOC1, AGL32, AP3/PI, SVP, AGL15, ANR1, and AG were identified. We identified and characterized the origin of a novel subfamily GMADS within gymnosperms but lost orthologs in monocots and Brassicaceae. ABCE model prototype genes were relatively conserved in terms of gene number in gymnosperms, but expanded in angiosperms, whereas SVP, SOC1, and GMADS had dramatic expansions in gymnosperms but conserved in angiosperms. Our results provided the most detailed evolutionary history of all MIKCc gene clades in gymnosperms and angiosperms. We proposed that although the near complete set of MIKCc genes had evolved in gymnosperms, the duplication and expressional transition of ABCE model MIKCc genes in the ancestor of angiosperms triggered the first flower.
Skin Fold Dermatitis in Douala: Prevalence, Etiology and Associated Factor

Introduction Dermatitis of folds or intertrigo, is an inflammatory condition of the skin folds or opposing skin surfaces induced or aggravated by heat, moisture, maceration, friction and lack of air circulation [1-4]. The moist damaged skin associated with skin fold dermatitis is a fertile breeding ground for various microorganism (bacteria, yeast or fungi), and secondary cutaneous infections are commonly observed in these areas [1, 3, 5, 6]. *Corresponding author: Ngaba GP, Faculte de Medicine et des Sciences Pharmaceutiques de Douala, Cameroon. E-mail: pascalngaba1974@gmail. com
Incidence, Predictors, and Outcomes Related to Hypo- and Hyperkalemia in Patients With Severe Heart Failure Treated With a Mineralocorticoid Receptor Antagonist

Background—Mineralocorticoid receptor antagonists reduce morbidity and mortality in patients with heart failure but can cause hyperkalemia, which contributes to reduced use of these drugs. Hypokalemia also leads to worse outcomes in patients with heart failure and may be attenuated by mineralocorticoid receptor antagonists. Methods and Results—We assessed incidence and predictors of hyperkalemia (potassium ≥5.5 mmol/L) and hypokalemia (potassium <3.5 mmol/L) and the relationship to outcomes in 1663 patients with class III or IV heart failure and left ventricular ejection fraction <35% randomized to treatment with spironolactone 25 mg or placebo in the Randomized Aldactone Evaluation Study (RALES) trial. All-cause mortality rates and the influence of potassium levels on the effectiveness of spironolactone were assessed in a landmark analysis and in relation to time-varying potassium levels. After 1 month, mean potassium levels increased in the spironolactone group but not in the placebo group (4.54±0.49 versus 4.28±0.50 mmol/L; P<0.001) and remained elevated during the trial. Although the extremes of hypokalemia and hyperkalemia at 4 weeks were associated with increased risk of mortality in both treatment arms, participants in the spironolactone arm had lower mortality rates at all potassium levels throughout the duration of the trial. The treatment benefit of spironolactone was maintained at least until potassium exceeded 5.5 mmol/L. Conclusions—With appropriate surveillance of potassium and creatinine, the use of spironolactone was associated with less hypokalemia and improved survival in patients with severe heart failure even in the setting of moderate hyperkalemia.
A pilot study: Auditory steady-state responses (ASSR) can be measured in human fetuses using fetal magnetoencephalography (fMEG)

Background Auditory steady-state responses (ASSRs) are ongoing evoked brain responses to continuous auditory stimuli that play a role for auditory processing of complex sounds and speech perception. Transient auditory event-related responses (AERRs) have previously been recorded using fetal magnetoencephalography (fMEG) but involve different neurological pathways. Previous studies in children and adults demonstrated that the cortical components of the ASSR are significantly affected by state of consciousness and by maturational changes in neonates and young infants. To our knowledge, this is the first study to investigate ASSRs in human fetuses. Methods 47 fMEG sessions were conducted with 24 healthy pregnant women in three gestational age groups (30–32 weeks, 33–35 weeks and 36–39 weeks). The stimulation consisted of amplitude-modulated (AM) tones with a duration of one second, a carrier frequency (CF) of 500 Hz and a modulation frequency (MF) of 27 Hz or 42 Hz. Both tones were presented in a random order with equal probability adding up to 80–100 repetitions per tone. The ASSR across trials was quantified by assessing phase synchrony in the cortical signals at the stimulation frequency. Results and Conclusion Ten out of 47 recordings were excluded due to technical problems or maternal movements. Analysis of the included 37 fetal recordings revealed a statistically significant response for the phase coherence between trials for the MF of 27 Hz but not for 42 Hz. An exploratory subgroup analysis moreover suggested an advantage in detectability for fetal behavioral state 2F (active asleep) compared to 1F (quiet asleep) detected using fetal heart rate. In conclusion, with the present study it was possible to detect human fetal ASSRs for the first time. These findings warrant further investigations of the developing fetal brain.
Immunologic strategies for HIV-1 remission and eradication

Antiretroviral therapy (ART) is able to suppress HIV-1 replication indefinitely in individuals who have access to these medications, are able to tolerate these drugs, and are motivated to take them daily for life. However, ART is not curative. HIV-1 persists indefinitely during ART as quiescent integrated DNA within memory CD4+ T cells and perhaps other long-lived cellular reservoirs. In this Review, we discuss the role of the immune system in the establishment and maintenance of the latent HIV-1 reservoir. A detailed understanding of how the host immune system shapes the size and distribution of the viral reservoir should lead to the development of a new generation of immune-based therapeutics, which may eventually contribute to a curative intervention.
The Impact of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Injury in Experimental Studies: A Systematic Review

Background. The impact of hepatic steatosis on outcome following hepatic ischemia-reperfusion injury (IRI) remains controversial with conflicting clinical results. A number of experimental studies have been published examining the relationship between hepatic steatosis and IRI. This systematic review evaluates these experimental studies. Methods. An electronic search of the Medline and Embase databases (January 1946 to June 2012) was performed to identify studies that reported relevant outcomes in animal models of hepatic steatosis subjected to IRI. Results. A total of 1314 articles were identified, of which 33 met the predefined criteria and were included in the study. There was large variation in the type of animal model, duration, and type of IRI and reporting of histological findings. Increased macrovesicular steatosis (>30%) was associated with increased histological damage, liver function derangement, and reduced survival. Increased duration of warm or cold ischemia had a negative impact on all outcomes measured. Microvesicular steatosis did not influence outcome. Conclusions. Findings from this systemic review support the hypothesis that livers with >30% macrovesicular steatosis are less tolerant of IRI. Clinically, it is likely that these findings are applicable to patients undergoing hepatic resection, but further studies are required to confirm these data.
Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas

In animal models of retinitis pigmentosa the dopaminergic system in the retina appears to be dysfunctional, which may contribute to the debilitated sight experienced by retinitis pigmentosa patients. Since dopamine D2-like receptors are known to modulate the activity of dopaminergic neurons, I examined the effects of dopamine D2-like receptor antagonists on the light responses of retinal ganglion cells (RGCs) in the P23H rat model of retinitis pigmentosa. Extracellular electrical recordings were made from RGCs in isolated transgenic P23H rat retinas and wild-type Sprague-Dawley rat retinas. Intensity-response curves to flashes of light were evaluated prior to and during bath application of a dopamine D2-like receptor antagonist. The dopamine D2/D3 receptor antagonists sulpiride and eticlopride and the D4 receptor antagonist L-745,870 increased light sensitivity of P23H rat RGCs but decreased light sensitivity in Sprague-Dawley rat RGCs. In addition, L-745,870, but not sulpiride or eticlopride, reduced the maximum peak responses of Sprague-Dawley rat RGCs. I describe for the first time ON-center RGCs in P23H rats that exhibit an abnormally long-latency (>200 ms) response to the onset of a small spot of light. Both sulpiride and eticlopride, but not L-745,870, reduced this ON response and brought out a short-latency OFF response, suggesting that these cells are in actuality OFF-center cells. Overall, the results show that the altered dopaminergic system in degenerate retinas contributes to the deteriorated light responses of RGCs.
Devices That Tell on You: Privacy Trends in Consumer Ubiquitous Computing

We analyze three new consumer electronic gadgets in order to gauge the privacy and security trends in mass-market UbiComp devices. Our study of the Slingbox Pro uncovers a new information leakage vector for encrypted streaming multimedia. By exploiting properties of variable bitrate encoding schemes, we show that a passive adversary can determine with high probability the movie that a user is watching via her Slingbox, even when the Slingbox uses encryption. We experimentally evaluated our method against a database of over 100 hours of network traces for 26 distinct movies. Despite an opportunity to provide significantly more location privacy than existing devices, like RFIDs, we find that an attacker can trivially exploit the Nike+iPod Sport Kit's design to track users; we demonstrate this with a GoogleMaps-based distributed surveillance system. We also uncover security issues with the way Microsoft Zunes manage their social relationships. We show how these products' designers could have significantly raised the bar against some of our attacks. We also use some of our attacks to motivate fundamental security and privacy challenges for future UbiComp devices.
Cavity backed antennas with multilayer superstrates

A superstrate (cover) dielectric or magnetic layers are often used to protect low profile conformal antennas, such as cavity backed antennas from environmental hazards. In this paper, the hybrid FEM/MoM is been used to handle any aperture configuration backed by arbitrary shaped and filled (with general anisotropic material) cavities with multilayered dielectric/magnetic superstrates. In the cavity region the vector FEM is used to compute for the electric field, while the combination of spectral/spatial domain MoM is used to compute the field in the exterior layered region. To demonstrate the accuracy of the method two cases are analyzed and compared with other methods and measurements.
Oral hygiene and periodontal treatment needs of urban school children compared with that of rural school children in Lagos State. Nigeria.

OBJECTIVE To assess the oral hygiene methods being used by the children in the urban and rural areas studied, the effect on their oral hygiene and the periodontal treatment needs of urban and rural school children. SETTING An urban and a rural local government area in Lagos State, Southwest Nigeria. DESIGN Cross-sectional and descriptive. METHOD 1829 primary school children from primary one to six were selected from thirteen fee-paying and non fee-paying schools using a multistage random sampling. One thousand, and twenty-three (1023) children were examined in the urban area and eight hundred and six (806) children were examined in the rural area. The simplified oral hygiene index of Greene and Vermillion and the Community Periodontal Index of Treatment needs (CPITN) were used to assess the oral hygiene status and Periodontal treatment needs respectively. RESULTS 205 (20%) of the children in the urban area use the toothbrush and toothpaste only and 84 (10.4%) of those in the rural area use only the toothbrush and toothpaste. 255 (31.6%) of the children in the rural area use only the chewing stick compared with 5 (0.5%) of the children in the urban area. Majority of the children use a combination of methods based on what is available. Children in the urban area had significantly better oral hygiene than those in the rural area but children from low social class in the urban area had significantly poorer oral hygiene than those from the high social clans. Majority of the children from the rural area and the low class urban area needed scaling and polishing. It was concluded that there is a need for improvement in oral hygiene of the children via oral health education. There is a greater need for middle level oral health manpower as the majority required scaling and polishing with oral hygiene instructions.
Attitudes of general practitioners in New Zealand to pharmaceutical representatives.

BACKGROUND Pharmaceutical representatives are a vital component of the marketing of pharmaceutical products and an important source of prescribing information for general practitioners. AIM A study was undertaken to explore the attitudes of New Zealand general practitioners to pharmaceutical representatives. METHOD A questionnaire survey of 100 general practitioners was undertaken to which 67 general practitioners responded. RESULTS The provision of practical prescribing advice by representatives and gifts relevant to medicine were seen as desirable activities by many respondents. However, gifts of value considerably greater than suggested acceptable in recent guidelines for general practitioners were also highly favoured by some practitioners. CONCLUSION Current ethical guidelines setting out the relationship between pharmaceutical representatives and medical practitioners are inadequate and should be based on the need for the general practitioner to become an unbiased promoter of patient health.
Use of hormone replacement therapy among danish nurses at increased risk of osteoporosis

Observational studies and recent randomized trials have shown that postmenopausal hormone replacement therapy (HRT) may reduce the risk of osteoporotic fractures by about 30 to 40%. In this study we used a log linear graphical model to determine whether women with a known increased risk of osteoporosis were more likely to use HRT than other women and to examine whether women at increased risk modified this risk through their lifestyle. Cox regression analysis was used to analyze if women at risk of osteoporosis used HRT longer than women not at risk. Participants were Danish female nurses who, in 1993, were between 50 and 69 years of age (N = 14,865). Data were collected from postal questionnaires. We concluded that nurses with a known family history of osteoporosis more often used HRT than nurses without this risk. No other direct associations were found between biological risk factors and ever use of HRT. The presence of biological risk factors of osteoporosis was not consistently modified by a healthier lifestyle. Nurses with a low body mass index (BMI) with a known family history of osteoporosis continued to use HRT longer than nurses without these risk factors.
Importance of machine learning for enhancing ecological studies using information-rich imagery

There is increasing demand for efficient ways to process large volumes of data from visual-based remote-technology, such as unmanned aerial vehicles (UAVs) in ecology and conservation, with machine learning methods representing a promising avenue to address varying user demands. Here, we evaluated current trends in how machine learning and UAVs are used to process imagery data for detecting animals and vegetation across habitats, placing emphasis on their utility for endangered species. We reviewed 213 publications that used UAVs at 256 study sites, of which just 89 (42%) used machine learning to assess the visual data. We evaluated geographical and temporal trends and identified how each technology is used at a global scale. We also identified the most commonly encountered machine-learning methods, including potential reasons for their limited use in ecology and possible solutions. Thirteen out of the 17 habitats defined by the International Union for Conservation of Nature (IUCN) habitat classification scheme were monitored using UAVs, while 12 habitats were monitored using both UAVs and machine learning. Our results show that, while machine learning is already being used across many habitat types, it is primarily restricted to more uniform habitats at present. Out of 173 plant and animal species monitored using UAV surveys, 30 were of conservation concern, with machine learning being used to assess UAV imagery data for 9 of these species. In conclusion, we anticipate that the joint use of UAVs and machine learning for ecological research and conservation will expand as machine learning methods become more accessible.
Child Exposure to Parental Violence and Psychological Distress Associated With Delayed Milestones

OBJECTIVE: To examine the association between parental report of intimate partner violence (IPV) and parental psychological distress (PPD) with child attainment of developmental milestones. METHODS: By using data collected from a large cohort of primary care patients, this cross-sectional study examined the relationship between parental report of IPV and/or PPD and the attainment of developmental milestones within the first 72 months of a child’s life. Multivariate logistic regression analyses were used to adjust for parental report of child abuse concern and sociodemographic characteristics. RESULTS: Our study population included 16 595 subjects. Children of parents reporting both IPV and PPD (n = 88; 0.5%) were more likely to fail at least 1 milestone across the following developmental domains: language (adjusted odds ratio [aOR] 2.1; 95% confidence interval [CI] 1.3–3.3), personal-social (aOR 1.9; 95% CI 1.2–2.9), and gross motor (aOR 3.0; 95% CI 1.8–5.0). Significant associations for those reporting IPV-only (n = 331; 2.0%) were found for language (aOR 1.4; 95% CI 1.1–1.9), personal-social (aOR 1.7; 95% CI 1.4–2.2), and fine motor-adaptive (aOR 1.7; 95% CI 1.0–2.7). Significant associations for those reporting PPD-only (n = 1920; 11.6%) were found for: language (aOR 1.5; 95% CI 1.3–1.7), personal-social (aOR 1.6; 95% CI 1.5–1.8), gross motor (aOR 1.6; 95% CI 1.4–1.8), and fine-motor adaptive (aOR 1.6; 95% CI 1.3–2.0). CONCLUSIONS: Screening children for IPV and PPD helps identify those at risk for poor developmental outcomes who may benefit from early intervention.