Miracle-dz/UniFAR-FTUs huggingface dataset:
Tectonic and climatic control of the changes in the sedimentary record of the Karnali River section (Siwaliks of western Nepal)

Abstract A multidisciplinary study was conducted on the section of the Siwalik Group sediments, approximately 5000 m thick, exposed along the Karnali River. Analysis of facies, clay mineralogy and neodymium isotope compositions revealed significant changes in the sedimentary record, allowing discussion of their tectonic or climatic origin. Two major changes within the sedimentary fill were detected: the change from a meandering to a braided river system at ca 9.5 Ma and the change from a deep sandy braided to a shallow sandy braided river system at ca 6.5 Ma. The 9.5‐Ma change in fluvial style is contemporaneous with an abrupt increase of ɛNd(0) values following a ɛNd(0) minimum. This evolution indicates a change in source material and erosion of Lesser Himalayan rocks within the Karnali catchment basin between 13 and 10 Ma. The tectonic activity along the Ramgarh thrust caused this local exhumation. By changing the proximity and morphology of relief, the forward propagation of the basal detachment to the main boundary thrust was responsible for the high gradient and sediment load required for the development of the braided river system. The change from a deep sandy braided to a shallow sandy braided river system at approximately 6.5 Ma was contemporaneous with a change in clay mineralogy towards smectite‐/kaolinite‐dominant assemblages. As no source rock change and no burial effect are detected at that time, the change in clay mineralogy is interpreted as resulting from differences in environmental conditions. The facies analysis shows abruptly and frequently increasing discharges by 6.5 Ma, and could be linked to an increase in seasonality, induced by intensification of the monsoon climate. The major fluvial changes deciphered along the Karnali section have been recognized from central to western Nepal, although they are diachronous. The change in clay mineralogy towards smectite‐/kaolinite‐rich assemblages and the slight decrease of ɛNd(0) have also been detected in the Bengal Fan sedimentary record, showing the extent and importance of the two major events recorded along the Karnali section.
Garlic shows promise for improving some cardiovascular risk factors.

OBJECTIVES To summarize the effects of garlic on several cardiovascular-related factors and to note its adverse effects. METHODS English and non-English citations were identified from 11 electronic databases, references, manufacturers, and experts from January 1966 through February 2000 (depending on the database searched). Reports of cardiovascular-related effects were limited to randomized controlled trials lasting at least 4 weeks. Reports of adverse effects were not limited by study design. From 1798 pertinent records, 45 randomized trials and 73 additional studies reporting adverse events were identified. Two physicians abstracted outcomes and assessed adequacy of randomization, blinding, and handling of dropouts. Standardized mean differences of lipid outcomes from placebo-controlled trials were adjusted for baseline differences and pooled using random effects methods. RESULTS Compared with placebo, garlic preparations may lead to small reductions in the total cholesterol level at 1 month (range of average pooled reductions, 0.03-0.45 mmol/L [1.2-17.3 mg/dL]) and at 3 months (range of average pooled reductions 0.32-0.66 mmol/L [12.4-25.4 mg/dL]), but not at 6 months. Changes in low-density lipoprotein levels and triglyceride levels paralleled total cholesterol level results; no statistically significant changes in high-density lipoprotein levels were observed. Trials also reported significant reductions in platelet aggregation and mixed effects on blood pressure outcomes. No effects on glycemic-related outcomes were found. Proven adverse effects included malodorous breath and body odor. Other unproven effects included flatulence, esophageal and abdominal pain, allergic reactions, and bleeding. CONCLUSIONS Trials suggest possible small short-term benefits of garlic on some lipid and antiplatelet factors, insignificant effects on blood pressure, and no effect on glucose levels. Conclusions regarding clinical significance are limited by the marginal quality and short duration of many trials and by the unpredictable release and inadequate definition of active constituents in study preparations.
Dexmedetomidine infusion as an anesthetic adjuvant to general anesthesia for appropriate surgical field visibility during modified radical mastectomy with i-gel®: a randomized control study

Background Modified radical mastectomy is associated with appreciable blood loss, while endotracheal intubation leads to elevated hemodynamic responses. The present study aimed to evaluate the clinical efficacy of dexmedetomidine infusion as an anesthetic adjuvant to general anesthesia during modified radical mastectomy with I-Gel. Methods Sixty adult consenting female patients, of American Society of Anesthesiologists physical status 1 to 2 and aged 4,065 years, were blindly randomized into two groups of 30 patients each. The patients in Group I received intravenous dexmedetomidine at a loading dose of 1 µg/kg over 10 min, followed by maintenance infusion of 0.4 to 0.7 µg/kg/h, while patients in Group II were administered an identical amount of saline infusion until 15 min prior to the end of surgery. The primary end point was bleeding at the surgical field and hemodynamic changes; requirement of isoflurane, intraoperative fentanyl consumption and recovery time were assessed as secondary outcomes. Results The patients receiving dexmedetomidine infusion showed significantly less bleeding at the surgical field (P < 0.05). A statistically significant reduction was also observed in the percentage of isoflurane required (0.82 ± 0.80%) to maintain the systolic blood pressure between 100 and 110 mmHg in patients receiving dexmedetomidine infusion compared with the Group II (1.50 ± 0.90%). The mean intraoperative fentanyl consumption in patients in the Group I was also significantly lower compared with that of the Group II (38.43 ± 5.40 µg vs. 75.12 ± 4.60 µg). The mean recovery time from anesthesia did not show any clinically significant difference between the groups. Conclusions Dexmedetomidine infusion can be used safely to decrease the bleeding at the surgical field with smooth recovery from anesthesia.
Stress intensity factors computation for bending plates with extended finite element method

The modelization of bending plates with through‐the‐thickness cracks is investigated. We consider the Kirchhoff–Love plate model, which is valid for very thin plates. Reduced Hsieh–Clough–Tocher triangles and reduced Fraejis de Veubeke–Sanders quadrilaterals are used for the numerical discretization. We apply the eXtended Finite Element Method strategy: enrichment of the finite element space with the asymptotic bending singularities and with the discontinuity across the crack. The main point, addressed in this paper, is the numerical computation of stress intensity factors. For this, two strategies, direct estimate and J‐integral, are described and tested. Some practical rules, dealing with the choice of some numerical parameters, are underlined. Copyright © 2012 John Wiley & Sons, Ltd.
Wafer‐Scale, Homogeneous MoS2 Layers on Plastic Substrates for Flexible Visible‐Light Photodetectors

An appropriate solution is suggested for synthesizing wafer-scale, continuous, and stoichiometric MoS2 layers with spatial homogeneity at the low temperature of 450 °C. It is also demonstrated that the MoS2 -based visible-light photodetector arrays are both fabricated on 4 inch SiO2 /Si wafer and polyimide films, revealing 100% active devices with a narrow photocurrent distribution and excellent mechanical durability.
Seeking information in realistic books: a user study

There are opposing views on whether readers gain any advantage from using a computer model of a 3D physical book. There is enough evidence, both anecdotal and from formal user studies, to suggest that the usual HTML or PDF presentation of documents is not always the most convenient, or the most comfortable, for the reader. On the other hand it is quite clear that while 3D book models have been prototyped and demonstrated, none are in routine use in today's digital libraries. And how do 3D book models compare with actual books? This paper reports on a user study designed to compare the performance of a practical Realistic Book implementation with conventional formats (HTML and PDF) and with physical books. It also evaluates the annotation features that the implementation provides.
Lifetime exposure to environmental tobacco smoke and cervical intraepithelial neoplasms among nonsmoking Taiwanese women.

Cigarette smoke is one of the most important environmental risk factors for the development of cervical intraepithelial neoplasms (CINs). Given that the prevalence of cigarette smoking in Taiwanese women is very low, compared with Caucasian women (3-4% vs. approximately 28%, respectively), direct smoking is likely a minimal risk factor in the Taiwanese group. However, the evaluation of the association between indirect tobacco exposure, or exposure to environmental tobacco smoke (ETS), and CIN risk in Taiwanese women may be enlightening. The authors designed a community-based nested case-control study to examine the association between ETS exposure and CIN risk among Taiwanese women who were nonsmokers. The study was conducted in Chia-Yi, a city in southwestern Taiwan. The test population comprised adult females (n = 32,466) who had undergone Pap smear screening during the 14-mo period that preceded this study. Potential cases were chosen from individuals who demonstrated positive Pap smear results, which were indicative of at least a level II cervical intraepithelial neoplasm (i.e., > or = CIN2), as confirmed by cervical biopsy (n = 116). The authors chose 2 matched controls for each case; criteria used were (a) the 2 controls for each case had to be approximately the same age (+/- 2 yr) as the case; (b) each case and respective control lived in the same residential area; and (c) each control had a negative Pap smear, determined during the same time frame (+/- 6 mo) that the matched study subject was tested. A total of 100 study subjects and 197 control females (3 cases had only 1 control) underwent interviews by public health nurses, who obtained information about the participants' active and passive smoking histories and other potential risk factors. The incidence of cigarette smoking was low (5.0% [n = 5]) in study subjects and lower in controls (3.1% [n = 6]). The authors' final analysis was restricted to 89 nonsmoking pairs (89 subjects and 175 controls). Of the affected subjects, 85.4% reported exposure to passive smoke at home during their adulthood, vs. 61.1% of controls. The authors found that, after adjusting for other covariates, there was a 2.73-fold increased risk of contracting CIN (95% confidence interval [CI] = 1.31, 5.67) among ETS-exposed individuals. The authors assessed cumulative dose in terms of pack-years (i.e., average daily exposure [number of packs smoked] multiplied by the number of years the same exposure continued). Compared with nonsmokers, women exposed to 1-20 pack-yr and more than 20 pack-yr had 1.90-fold (95% CI = 0.72, 5.03) and 2.99-fold (95% CI = 1.10, 8.09) increased risks, respectively, of developing CIN. The authors concluded that lifetime ETS exposure is a major determinant for contracting cervical neoplasms among nonsmoking women in Taiwan.
Positive effects of promoting prosocial behavior in early adolescence

The purpose of this study was to evaluate the effects of a pilot school-based intervention called CEPIDEA, designed to promote prosocial behavior in early adolescence. The study took place in a middle school located in a small city near Rome. The intervention group included 151 students (52.3% males; Mage = 12.4), and the control group 173 students (50.3% females; Mage = 13.0). Both groups were assessed at three time points, each 6 months apart. A Latent Growth Curve analysis revealed that the intervention group, compared to the control group, showed an increase of helping behavior along with a decrease of physical and verbal aggression across time. Current results also showed that the increase of helping behavior mediated the decline of verbal aggression in adolescents who had attended the intervention. Participants of CEPIDEA also attained higher grades than the control group at the end of middle school. Overall, findings suggest that promoting prosocial behavior may serve to counteract aggressive conduct and enhance academic achievement during adolescence.
A comparative study of the clinico-aetiological profile of hyponatremia at presentation with that developing in the hospital

Background & objectives: Hyponatremia is a common problem encountered in patients presenting with nonspecific symptoms. We undertook this study to investigate the clinical profile of patients with hyponatremia, the precipitating factors, the response to therapy and to compare, using these parameters, hyponatremia at presentation to that developing in the hospital. Methods: Seventy consecutive patients with serum sodium less than or equal to 125 mmol/l at presentation or at any time during hospital admission were identified and studied using a proforma. The severity of hyponatremia, therapy given and time taken for recovery were analysed. Results: The mean age of patients was 48.1 ± 16.1 yr. The mean serum sodium was 117.8 ± 6.4 mmol/l. Confusion, headache and malaise were the most common symptoms, two patients had seizures, and 20.0 per cent patients showed no clinical manifestations. Nausea was significantly (P<0.05) more common in patients presenting with hyponatremia. 22 patients (31.4%) developed hyponatremia during their stay in the hospital. 3 patients (4.3%) presented with hyponatremia which got worse during the admission period. Most had multiple precipitating factors, decreased intake being the most common (82.9%), followed by increased losses (65.7%) and miscellaneous factors (70.0%). Drugs, fluid overload and inappropriate Ryle's tube feeds more commonly precipitated hyponatremia in in-hospital patients. Time taken for recovery showed negative correlation with the serum sodium. Patients with in-hospital hyponatremia took significantly longer time to recover (P<0.05). Interpretation & conclusions: Decreased intake was found to be the commonest cause of hyponatremia, thus, ensuring adequate oral intake, especially in patients on liquid diet and in manual labourers, and correction of hyponatremia as soon as an abnormality is detected is important.
Human papillomavirus prevalence and type in liquid-based Human papillomavirus prevalence and type in liquid-based cervical samples from Turkish women in a selected risk group cervical samples from Turkish women in a selected risk group

and 90.8% of cytologically positive samples. The most common types of HPV detected were 16, 6, 18, 31, 66, 56, 53, 81, 45, and 62. Of HPV DNA-positive samples, 47.7% were high, 4.7% were intermediate, and 17.9% were low risk. The high-risk types of HPV detected were 16, 18, 31, 56, 53, 45, 62, 58, 59, 67, 51, 35, 73, 52, 33, 39, 68, and 82.
Lateral Thigh Free Flap With Flow-Through Vascular Pedicle

The lateral thigh flap based on the second and third perforator of profunda femoris vessel has not become very popular. We describe a technique of flow-through pedicle for this flap. The flow-through technique makes this flap very simple to transfer. The flap was used successfully in 6 cases for reconstruction for defects in the leg and forearm. The flow-through pedicle is ideal for lower limb reconstruction. The anastomosis becomes very easy and safe, even if the recipient vessels are deep in the intermuscular septum. We had no flap failures. The flap has a very predictable anatomy. Large flaps from anteriolateral and posterior part of midthigh can be safely elevated. The flap can meet a variety of requirements as it can be thin skin-alone flap, a fasciocutaneous flap, or even a musculocutaneous flap. A simple pinch test gives a fair idea of expected flap thickness. The dissection requires strong retraction of the anterior thigh muscles, but the dissection is safe and simple. The donor-site morbidity is very minimal.
Various nano-particles influences on structure, viscoelastic, Vulcanization and mechanical behaviour of EPDM nano-composite rubber foam

In this study, the effect of various nano-particle type and concentration on the structure, curing, viscosity variation during vulcanisation, and mechanical characteristics of ethylene–propylene–diene monomer (EPDM) rubber foam is reported. Three types of nanoparticle with various dimensional aspects (1D carbon nanotubes, 2D nano clay, and 3D nano silica) are employed to investigate their effect on the fabrication of EPDM rubber foam. It is observed that the properties of the foams were efficiently influenced by the nano-particle shapes and content in the matrix. Nanoparticles may increase cell density and change cell structures. In addition, they can change the curing behaviour of foam rubber by affecting curing rate and scorch time of rubber. In the end, mechanical properties of EPDM foam rubbers investigated by experimental tests and implementing few empirical and constitutional mechanical models. It is very helpful to use suitable nanoparticle to achieve desired properties out of fabricated foams.
Prevalence of Nontuberculous Mycobacteria among Extrapulmonary Tuberculosis Cases in Tertiary Care Centers in Northern India

The reports of nontuberculous mycobacteria (NTM) associated with extrapulmonary diseases are increasing in tertiary care hospitals. Despite a significant increase in knowledge about NTM infections, they still represent a diagnostic and therapeutic challenge. The aim of this study is to know the prevalence of NTN among extrapulmonary tuberculosis cases in tertiary care centers in Northern India. A total of 227 culture positive isolates from 756 cases were tested for niacin production and catalase assay. BIO-LINE SD Ag MPT64 TB test and final identification and differentiation between MTBC and different species of NTM were further confirmed by GenoType Mycobacterium CM/AS assay. 71 cases (9.3%) were positive for AFB by ZN staining and 227 cases (30.1%) were positive for mycobacteria by culture. Niacin production and catalase activity were negative in 62/227 (27.4%) strains and after using a panel of different biochemicals and final confirmation by GenoType Mycobacterium CM assay. Out of 227 cultures tested, 165 (72.6%) strains were confirmed as M. tuberculosis complex, and 62 (27.4%) were confirmed as NTM. The most common NTM species identified were M. fortuitum 17 (27.5%) and M. intracellulare 13 (20.9%). The rapid identification of NTM species may help in targeted therapy and management of the diseases.
Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection

The innate immune system is essential for controlling viral infection. Hepatitis B virus (HBV) persistently infects human hepatocytes and causes hepatocellular carcinoma. However, the innate immune response to HBV infection in vivo remains unclear. Using a tree shrew animal model, we showed that HBV infection induced hepatic interferon (IFN)-γ expression during early infection. Our in vitro study demonstrated that hepatic NK cells produced IFN-γ in response to HBV only in the presence of hepatic F4/80+ cells. Moreover, extracellular vesicles (EVs) released from HBV-infected hepatocytes contained viral nucleic acids and induced NKG2D ligand expression in macrophages by stimulating MyD88, TICAM-1, and MAVS-dependent pathways. In addition, depletion of exosomes from EVs markedly reduced NKG2D ligand expression, suggesting the importance of exosomes for NK cell activation. In contrast, infection of hepatocytes with HBV increased immunoregulatory microRNA levels in EVs and exosomes, which were transferred to macrophages, thereby suppressing IL-12p35 mRNA expression in macrophages to counteract the host innate immune response. IFN-γ increased the hepatic expression of DDX60 and augmented the DDX60-dependent degradation of cytoplasmic HBV RNA. Our results elucidated the crucial role of exosomes in antiviral innate immune response against HBV. Accession Number Accession number of RNA-seq data is DRA004164 (DRA in DDBJ).
Coverage in WLAN with Minimum Number of Access Points

When designing wireless communication systems, it is very important to know the optimum numbers and locations for the access points (APs). The impact of incorrect placement of APs is significant. Placing too many access points increases the cost of deployment and interference, while placing too few access points can lead to coverage gaps. In this paper we describe a novel mathematical model developed to find the optimal number of APs and their locations in an environment that includes obstacles. To solve the problem, we use a new global optimization (AGOP) algorithm. The results obtained indicate that our model and software is able to solve optimal coverage problems for a design area with different number of users
Functional changes in motoneurones of hemiparetic patients

Forty-six patients have been studied after upper motor neurone lesions of cerebrovascular origin. The numbers of functioning motor units in extensor digitorum brevis muscles were reduced to approximately half between the second and sixth months after a hemiplegic episode. The surviving motor units tended to have slow twitches and appeared to increase their sizes after the lesions had been present for about 20 months. The findings are explained on the basis of transsynaptic changes in alpha-motoneurones after degeneration of corticospinal fibres.
Throughput performance of MIMO cognitive networks

We analyze the throughput performance of cognitive ad-hoc networks. The designed network use modified IEEE 802.11 MAC protocol for media access purpose. Also, cognitive communication is limited by the interference imposed on primary users for the designed cognitive network. First, we determine the channel availability probability for this opportunistic network. We then use this probability to propose the embedded Markov model in the cognitive nodes. Using this Markov model we determine the normalized throughput of cognitive nodes. The normalized throughput, variance in throughput and percentage of dropped packets performance reveals that number of cognitive nodes, transmit power, packet length, primary users' interference constraint, and number of antennas used have significant effect on the channel availability and throughput.
Cytomegalovirus ischemic colitis of a diabetic renal transplant recipient

Abstract: We report a diabetic renal transplant recipient with cytomegalovirus (CMV) disease who presented with tarry stool diarrhea because of multiple colonic ulcerations. Histopathology revealed diffuse colonic ulcers following a process of ischemic vasculitis. The colonic ulcers disappeared dramatically after 2 wk of intravenous ganciclovir therapy. Hyper‐immunosuppression was initially suspected but acute rejection (AR) developed after immunosuppressive reduction during the ganciclovir therapy. The AR was successfully reversed and the dosage of cyclosporine was returned to the same level prior to the onset of CMV disease. Our experience suggests that ganciclovir is quite effective for healing colonic ulcers caused by CMV and acute allograft rejection may occur during therapy.