Miracle-dz/UniFAR-FTUs huggingface dataset:
The Spectrum of a Parametrized Partial Differential Operator Occurring in Hydrodynamics

A partial differential operator associated with natural oscillations of an incompressible fluid in the neighbourhood of an elliptical flow is considered. The differentiation is only taken with respect to the angular variable, and thus the operator becomes a family of ordinary differential operators parametrized by the radial variable. It is shown that the spectra of these ordinary differential operators completely determine the spectrum of the given operator which turns out to have a kind of skeleton structure.
AlOx/AlGaAs technology for multi-plane integrated photonic devices

The III-V semiconductor /oxide technology has become the standard fabrication technique for Vertical-Cavity Surface-Emitting Lasers. Current research aims to further enhance the performance of these emitters and diversify the range of devices that can be made using this technology. In this paper, we present a new model of the oxidation process which includes the anisotropic behaviour observed during conventional lateral oxidation. Furthermore, we demonstrate that this technology can be used as an innovative method to make micro-disk resonators with vertically-coupled access waveguides, an approach which can be generalised to fabricate other types of multi-plane photonic devices.
Effects of the Lasater's Clinical Rubric of Debriefing in Advanced Cardiovascular Life Support Training

본 연구의 목적은 시뮬레이션 수업 후 Lasater의 임상판단 루브릭을 이용한 디브리핑이 간호학생의 비판 적 사고성향, 문제해결능력과 임상판단력에 미치는 효과를 검증하는 것이다. 비동등성 대조군 전후 시차설 계를 이용한 실험연구이며, 연구대상은 12그룹 60명으로 무작위로 실험군 (n=30)과 대조군 (n=30)을 배정 하고, 실험군에게는 시뮬레이션 교육과 Lasater의 임상판단 루브릭을 적용한 디브리핑을 실시하고, 대조군 에게는 구조화된 도구를 사용하는 것이 아니라 질문과 피드백으로 이루어진 일반적 디브리핑을 실시하였다. 자료수집은 2015년 6월 15일부터 6월 22일까지 이루어졌으며 비판적 사고성향과 문제해결능력은 자가보고 형 설문지를 이용하여 측정하였고 임상판단력은 Lasater의 임상판단 루브릭으로 측정하였다. 연구결과 비 판적 사고성향은 실험군은 실험 전 3.5±1. 4점에서 실험 후 3.6±1. 3점, 대조군은 실험 전 3.5±1. 4점에서 실험 후 3.4±1. 2점(t=1.86, p= .022), 문제해결능력은 실험군은 실험 전 3.4±1. 6점에서 실험 후 4.0±1. 8점, 대조군 은 실험 전 3.5±1. 5점에서 실험 후 3.6±1. 6점(t=3.21, p=< .011) 및 임상판단력은 실험 후 실험군은 11.5±1.7, 대조군은 9.3±2.3(t=4.14, p=< .001)으로 실험 후 비판적 사고성향, 문제해결능력, 임상판단력 모두 실험군 이 대조군보다 통계적으로 유의하게 높게 나타났다. 이를 통해 Lasater의 임상판단 루브릭을 이용한 디브리 핑은 임상판단력을 향상시키는데 유익하므로 시뮬레이션교육에서 Lasater의 임상판단 루브릭을 사용하는 디브리핑이 필요하다고 사료된다.
Photon path length distributions for cloudy skies – oxygen A-Band measurements and model calculations

Abstract. This paper addresses the statistics underlying cloudy sky radiative transfer (RT) by inspection of the distribution of the path lengths of solar photons. Recent studies indicate that this approach is promising, since it might reveal characteristics about the diffusion process underlying atmospheric radiative transfer (Pfeilsticker, 1999). Moreover, it uses an observable that is directly related to the atmospheric absorption and, therefore, of climatic relevance. However, these studies are based largely on the accuracy of the measurement of the photon path length distribution (PPD). This paper presents a refined analysis method based on high resolution spectroscopy of the oxygen A-band. The method is validated by Monte Carlo simulation atmospheric spectra. Additionally, a new method to measure the effective optical thickness of cloud layers, based on fitting the measured differential transmissions with a 1-dimensional (discrete ordinate) RT model, is presented. These methods are applied to measurements conducted during the cloud radar inter-comparison campaign CLARE’98, which supplied detailed cloud structure information, required for the further analysis. For some exemplary cases, measured path length distributions and optical thicknesses are presented and backed by detailed RT model calculations. For all cases, reasonable PPDs can be retrieved and the effects of the vertical cloud structure are found. The inferred cloud optical thicknesses are in agreement with liquid water path measurements. Key words. Meteorology and atmospheric dynamics (radiative processes; instruments and techniques)
Semiquantitative analysis of the histopathological features of the neuropathic foot ulcer: effects of pressure relief.

OBJECTIVE This study was designed to evaluate the histopathology of neuropathic ulcers and whether pressure relief could change such histological patterns. RESEARCH DESIGN AND METHODS We compared neuropathic plantar ulcers tissue excised from 10 diabetic patients (group A) with those taken from 10 patients with comparable lesions and glycemic control after 20 days in a total contact cast (group B). Tissue specimens were blindly examined by two independent pathologists for hyperkeratosis, fibrosis, cutaneous annexes, capillaries, inflammation, cellular debris, and granulating tissue. For each parameter, quantification was obtained according to an arbitrary score: 0, absent; 1, present in <33%; 2, present in 34-66%; and 3, present in >67% of the lesion. RESULTS Patients in group B showed a marked reduction in ulcer size after 20 days of casting (P < 0.01). The histopathological features of the two groups markedly differed. Group A patients showed a predominance of inflammatory elements as well as matrix alterations, vessel disruptions, inflammation, and debris. Group B ulcers showed a shift toward a reparative pattern with prevalence of neoformed capillaries and fibroblasts. Semiquantitative analysis confirmed the prevalence of hyperkeratosis, fibrosis, inflammation, and cellular debris in group A patients (P < 0.05), whereas cutaneous annexes, capillaries, and granulating tissue were more prevalent in group B lesions (P < 0.01). CONCLUSIONS These results indicate that pressure relief with a total contact cast is associated with changes in the histology of neuropathic foot ulcers, indicating reduction of inflammatory and reactive components and acceleration of reparative processes.
Effect of Instructing Care Program Through Group Discussion on the Quality of Life of the Parents of the Children Afflicted With Leukemia

Purpose: Children long-term involvement with cancer may have a negative impact on the quality of life their parents. Design and implementation of training programs for parents whose children have been diagnosed with leukemia, as the primary caregivers of children, will have a special significance and can contribute to better taking care of such children. The main purpose of the present study was to examine the impact of conducting group discussion, as care program training, on the quality of life parents whose children were suffering from leukemia. Methods: This quasi-experimental before-after intervention study encompassed two groups of parents (in total 41) of leukemia children. To collect data, a demographic questionnaire and the shortened version of SF-36 questionnaire were used to determine the quality of life of parents. Both groups completed the quality of life questionnaires before and two months after the intervention. Results: Comparison of the parents’ quality of life mean scores, obtained before and two months after training, showed that promotion in 6 domains of bodily pain, general health, emotional health, role limitation due to emotional problems, social functioning, and vitality were occurred. (P <0.05) Conclusions: Considering the important role of parents in taking care of children suffering from leukemia, introduction of care program training can be a positive step to help these parents and empower them to manage their children’s problems more systematically and will ultimately lead to improved quality of life of parents.
Basal Jawed Vertebrate Phylogenomics Using Transcriptomic Data from Solexa Sequencing

The traditionally accepted relationships among basal jawed vertebrates have been challenged by some molecular phylogenetic analyses based on mitochondrial sequences. Those studies split extant gnathostomes into two monophyletic groups: tetrapods and piscine branch, including Chondrichthyes, Actinopterygii and sarcopterygian fishes. Lungfish and bichir are found in a basal position on the piscine branch. Based on transcriptomes of an armored bichir (Polypterus delhezi) and an African lungfish (Protopterus sp.) we generated, expressed sequences and whole genome sequences available from public databases, we obtained 111 genes to reconstruct the phylogenetic tree of basal jawed vertebrates and estimated their times of divergence. Our phylogenomic study supports the traditional relationship. We found that gnathostomes are divided into Chondrichthyes and the Osteichthyes, both with 100% support values (posterior probabilities and bootstrap values). Chimaeras were found to have a basal position among cartilaginous fishes with a 100% support value. Osteichthyes were divided into Actinopterygii and Sarcopterygii with 100% support value. Lungfish and tetrapods form a monophyletic group with 100% posterior probability. Bichir and two teleost species form a monophyletic group with 100% support value. The previous tree, based on mitochondrial data, was significantly rejected by an approximately unbiased test (AU test, p = 0). The time of divergence between lungfish and tetrapods was estimated to be 391.8 Ma and the divergence of bichir from pufferfish and medaka was estimated to be 330.6 Ma. These estimates closely match the fossil record. In conclusion, our phylogenomic study successfully resolved the relationship of basal jawed vertebrates based on transtriptomes, EST and whole genome sequences.
Cloning and Characterization of Two Pyruvate Decarboxylase Genes from Pichia stipitis CBS 6054

ABSTRACT In Pichia stipitis, fermentative and pyruvate decarboxylase (PDC) activities increase with diminished oxygen rather than in response to fermentable sugars. To better characterizePDC expression and regulation, two genes for PDC (PsPDC1 and PsPDC2) were cloned and sequenced from P. stipitis CBS 6054. Aside from Saccharomyces cerevisiae, from which three PDC genes have been characterized,P. stipitis is the only organism from which multiple genes for PDC have been identified and characterized. PsPDC1 andPsPDC2 have diverged almost as far from one another as they have from the next most closely related known yeast gene.PsPDC1 contains an open reading frame of 1,791 nucleotides encoding 597 amino acids. PsPDC2 contains a reading frame of 1,710 nucleotides encoding 570 amino acids. An 81-nucleotide segment in the middle of the β domain of PsPDC1 codes for a unique segment of 27 amino acids, which may play a role in allosteric regulation. The 5′ regions of both P. stipitis genes include two putative TATA elements that make them similar to the PDC genes from S. cerevisiae, Kluyveromyces marxianus, and Hanseniaspora uvarum.
REAC neuromodulation treatments in subjects with severe socioeconomic and cultural hardship in the Brazilian state of Pará: a family observational pilot study

Purpose The purpose of this preliminary observational study was to evaluate the usefulness of a humanitarian initiative, aimed at improving the neuropsychological and behavioral attitude of children with severe socioeconomic and cultural hardship, in the Brazilian state of Pará. This humanitarian initiative was realized through the administration of two neuromodulation protocols, with radioelectric asymmetric conveyor (REAC) technology. During several years of clinical use, the REAC neuromodulation protocols have already proved to be effective in countering the effects of environmental stress on neuropsycho-physical functions. Patients and methods After the preliminary medical examination, all subjects were investigated with the Strengths and Difficulties Questionnaire (SDQ), including the impact supplement with teacher’s report. After the SDQ, they received the neuromodulation treatment with REAC technology named neuro postural optimization (NPO), to evaluate their responsiveness. Subsequently, every 3 months all subjects underwent a treatment cycle of neuropsycho-physical optimization (NPPO) with REAC technology, for a total of three cycles. At the end of the last REAC-NPPO treatment cycle, all subjects were investigated once again with the SDQ. For the adequacy of the data, the Wilcoxon and the Signs tests were used. For the subdivision into clusters, the Kruskal–Wallis test was applied for the adequacy of the procedure. For all the applied tests, a statistical significance of p<0.5 was found. Results The results showed that the REAC-NPO and REAC-NPPO neuromodulation protocols are able to improve the quality of life, the scholastic and socialization skills, and the overall state of physical and mental health in children of a family with severe socioeconomic and cultural hardship. Conclusion The REAC-NPO and REAC-NPPO neuromodulation protocols, due to their non-invasive characteristics, painlessness, and speed of administration, can be hypothesized as a treatment to improve the overall state of physical and mental health in a large number of people with socioeconomic and cultural discomfort.
Damage Evolution in Complex-Phase and Dual-Phase Steels during Edge Stretching

The role of microstructural damage in controlling the edge stretchability of Complex-Phase (CP) and Dual-Phase (DP) steels was evaluated using hole tension experiments. The experiments considered a tensile specimen with a hole at the center of specimen that is either sheared (sheared edge condition) or drilled and then reamed (reamed edge condition). The damage mechanism and accumulation in the CP and DP steels were systematically characterized by interrupting the hole tension tests at different strain levels using scanning electron microscope (SEM) analysis and optical microscopy. Martensite cracking and decohesion of ferrite-martensite interfaces are the dominant nucleation mechanisms in the DP780. The primary source of void nucleation in the CP800 is nucleation at TiN particles, with secondary void formation at martensite/bainite interfaces near the failure strain. The rate of damage evolution is considerably higher for the sheared edge in contrast with the reamed edge since the shearing process alters the microstructure in the shear affected zone (SAZ) by introducing work-hardening and initial damage behind the sheared edge. The CP microstructures were shown to be less prone to shear-induced damage than the DP materials resulting in much higher sheared edge formability. Microstructural damage in the CP and DP steels was characterized to understand the interaction between microstructure, damage evolution and edge formability during edge stretching. An analytical model for void evolution and coalescence was developed and applied to predict the damage rate in these rather diverse microstructures.
A Prediction for Teacher Commitment; Effects of Managerial Style, Burnout and Demographics

The Purpose of this study is to determine the effects of managerial style, teacher burnout and demographics on teacher commitment. In accordance with this aim, a quantitative casual research design was implemented. Data of the research were gathered from 280 primary school teacher, by a questionnaire including managerial style, teacher burnout, teacher commitment and teacher demographics forms. For each research questions, Hierarchical Linear Regression analysis was carried out. According to the findings, task oriented behaviors of principal, emotional exhaustion level of the teacher, self-inadequacy feelings of teacher, marital status and work time spending at the same school predicts teacher commitment significantly. On the other hand, human orientation, isolation level from work environment, physical burnout level, vocational burnout level, gender, professional experience, educational level and working status variables does not predicts teacher commitment.
TEAM: A Transportable Natural-Language Interface System

A majo r b e n e f i t of u s i n g n a t u r a l l anguage to a c c e s s the i n f o r m a t i o n in a d a t a b a s e i s t h a t i t shifts onto the system the burden of m e d i a t i n g between two views of the d a t a : the way in which the da ta i s s t o r e d ( t h e " d a t a b a s e v i e w " ) , and the way in which an e n d u s e r t h i n k s abou t i t ( t h e " u s e r * s v i e w " ) . Da tabase i n f o r m a t i o n i s r eco rded in terms of files, r e c o r d s , and fields, while natural-language expressions refer to the same information i n terms of entities and relationships in the world. A major problem in constructing a natural-language interface is determining how to encode and use the information needed to bridge these two views. Current natural-language interface systems require extensive efforts by specialists in natural-language processing to p r o v i d e them w i t h the i n f o r m a t i o n they need to do the b r i d g i n g . The systems are, in effect, handtallored to provide access to particular databases.
The Best of Both Worlds – A Graph-based Completion Model for Transition-based Parsers

Transition-based dependency parsers are often forced to make attachment decisions at a point when only partial information about the relevant graph configuration is available. In this paper, we describe a model that takes into account complete structures as they become available to rescore the elements of a beam, combining the advantages of transition-based and graph-based approaches. We also propose an efficient implementation that allows for the use of sophisticated features and show that the completion model leads to a substantial increase in accuracy. We apply the new transition-based parser on typologically different languages such as English, Chinese, Czech, and German and report competitive labeled and unlabeled attachment scores.
A Novel Mitochondrial KATP Channel Assay

Rationale: The mitochondrial ATP sensitive potassium channel (mKATP) is implicated in cardioprotection by ischemic preconditioning (IPC), but the molecular identity of the channel remains controversial. The validity of current methods to assay mKATP activity is disputed. Objective: We sought to develop novel methods to assay mKATP activity and its regulation. Methods and Results: Using a thallium (Tl+)-sensitive fluorophore, we developed a novel Tl+ flux based assay for mKATP activity, and used this assay probe several aspects of mKATP function. The following key observations were made. (1) Time-dependent run down of mKATP activity was reversed by phosphatidylinositol-4,5-bisphosphate (PIP2). (2) Dose responses of mKATP to nucleotides revealed a UDP EC50 of ≈20 &mgr;mol/L and an ATP IC50 of ≈5 &mgr;mol/L. (3) The antidepressant fluoxetine (Prozac) inhibited mKATP (IC50 =2.4 &mgr;mol/L). Fluoxetine also blocked cardioprotection triggered by IPC, but did not block protection triggered by a mKATP-independent stimulus. The related antidepressant zimelidine was without effect on either mKATP or IPC. Conclusions: The Tl+ flux mKATP assay was validated by correlation with a classical mKATP channel osmotic swelling assay (R2=0.855). The pharmacological profile of mKATP (response to ATP, UDP, PIP2, and fluoxetine) is consistent with that of an inward rectifying K+ channel (KIR) and is somewhat closer to that of the KIR6.2 than the KIR6.1 isoform. The effect of fluoxetine on mKATP-dependent cardioprotection has implications for the growing use of antidepressants in patients who may benefit from preconditioning.
The analytical validation of the Oncotype DX Recurrence Score assay

In vitro diagnostic multivariate index assays are highly complex molecular assays that can provide clinically actionable information regarding the underlying tumour biology and facilitate personalised treatment. These assays are only useful in clinical practice if all of the following are established: analytical validation (i.e., how accurately/reliably the assay measures the molecular characteristics), clinical validation (i.e., how consistently/accurately the test detects/predicts the outcomes of interest), and clinical utility (i.e., how likely the test is to significantly improve patient outcomes). In considering the use of these assays, clinicians often focus primarily on the clinical validity/utility; however, the analytical validity of an assay (e.g., its accuracy, reproducibility, and standardisation) should also be evaluated and carefully considered. This review focuses on the rigorous analytical validation and performance of the Oncotype DX® Breast Cancer Assay, which is performed at the Central Clinical Reference Laboratory of Genomic Health, Inc. The assay process includes tumour tissue enrichment (if needed), RNA extraction, gene expression quantitation (using a gene panel consisting of 16 cancer genes plus 5 reference genes and quantitative real-time RT-PCR), and an automated computer algorithm to produce a Recurrence Score® result (scale: 0–100). This review presents evidence showing that the Recurrence Score result reported for each patient falls within a tight clinically relevant confidence interval. Specifically, the review discusses how the development of the assay was designed to optimise assay performance, presents data supporting its analytical validity, and describes the quality control and assurance programmes that ensure optimal test performance over time.
The Role of Ekman Ocean Heat Transport in the Northern Hemisphere Response to ENSO

Abstract The influence of oceanic Ekman heat transport (Qek) on air–sea variability associated with ENSO teleconnections is examined via a pair of atmospheric general circulation model (AGCM) experiments. In the mixed layer model (MLM) experiment, observed sea surface temperatures (SSTs) for the years 1950–99 are specified over the tropical Pacific, while a grid of mixed layer models is coupled to the AGCM elsewhere over the global oceans. The same experimental design was used in the Ekman transport/mixed layer model (EKM) experiment with the addition of Qek in the mixed layer ocean temperature equation. The ENSO signal was evaluated using differences between composites of El Nino and La Nina events averaged over the 16 ensemble members in each experiment. In both experiments the Aleutian low deepened and the resulting surface heat fluxes cooled the central North Pacific and warmed the northeast Pacific during boreal winter in El Nino relative to La Nina events. Including Qek amplified the ENSO-related SS.
The Relationship Between Interparental Relationship, Parent-Child Relationship and Adolescents' Internet Addiction

This study, by using questionnaires to test 1038 students from three lower secondary schools in Beijing, Chongqing and Shijiazhuang based on the Spillover Theory and the Person-Context Interaction Theory,aims to explore the relationship between the interparental relationship( interparental conflicts and parents'marital satisfaction), the parent-child relationship( mother-child attachment and father-child attachment), and adolescents'Internet addiction, as well as whether the interparental relationship has an effect on adolescents'Internet addiction through the parent-child relationship. The results show the following:( 1) the parents'marital satisfaction, father-child attachment, and mother-child attachment are negatively correlated with the adolescents'Internet addiction, whereas interparental conflicts are positively correlated with the adolescents'Internet addiction;( 2) mother-child attachment, parents'marital satisfaction, and father-child attachment, rather than interparental conflicts, can help negatively predict the adolescents'Internet addiction;( 3) the effect of interparental conflicts on the adolescents'Internet addiction is totally mediated by father-child attachment and mother-child attachment,whereas the effect of the adolescents'parents'marital satisfaction on their Internet addiction is only partly mediated by father- child attachment and mother-child attachment.