Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparative study of PD-L1 immunohistochemical assays with four reliable antibodies in thymic carcinoma

Currently, four immunohistochemical assays are registered with the US Food and Drug Administration to detect the expression of PD-L1. We investigated the PD-L1 expression in thymic carcinomas using these four diagnostic assays. The cases of 53 patients were reviewed and their specimens were subjected to four PD-L1 assays with different antibodies (SP142, SP263, 22C3, and 28-8). The PD-L1 expression in tumor cells (TCs) and immune cells (ICs) was evaluated. In TCs, the four assays showed similar scores in each case. Histopathologically, high TC scores were observed in squamous cell carcinomas (SqCCs). Meanwhile, there were no significant relationships among the IC scores in the four assays. In SqCCs, the high expression of PD-L1 (defined as ≥50% TC score) in TCs tended to be associated with early stage cancer. The patients with high expression levels of PD-L1 tended to show longer overall survival in the 22C3 assays (p=0.0200). In thymic carcinomas, the staining pattern showed high concordance among the four assays when TCs – rather than ICs – were stained. High PD-L1 positivity in TCs, especially in SqCCs, indicated that PD-1/PD-L1 targeted therapy may be a promising therapeutic approach.
The Influence of Routine Interdependence and Skillful Accomplishment on the Coordination of Standardizing and Customizing

This paper advances understanding of the coordination of interdependence between multiple intersecting routines and its influence on the balancing of coexisting ostensive patterns. Building on a professional service routine—the deal appraisal routine—and its intersections with four related routines, we develop a dynamic framework that explains the coordination of standardization and flexibility in four ways. First, intersecting routines have shifting salience in the performance of a focal routine, and this shifting salience is enacted through professional skill and judgment. Second, each intersection amplifies pressure toward one or the other ostensive pattern thus introducing dynamism into the balancing of competing ostensive patterns. Third, professionals skillfully acknowledge these pressures from intersecting routines to orient toward one ostensive pattern and then reorient the performance of the routine toward the opposite ostensive pattern. Fourth, this balancing act, which we theorize as reciprocal task interdependence, occurs within the moment of performing each task, so providing a highly dynamic understanding of the association between routine interdependence and the coordination of coexisting ostensive patterns.
Automated Detection of Atrial Fibrillation Based on Time–Frequency Analysis of Seismocardiograms

In this paper, a novel method to detect atrial fibrillation (AFib) from a seismocardiogram (SCG) is presented. The proposed method is based on linear classification of the spectral entropy and a heart rate variability index computed from the SCG. The performance of the developed algorithm is demonstrated on data gathered from 13 patients in clinical setting. After motion artifact removal, in total 119 min of AFib data and 126 min of sinus rhythm data were considered for automated AFib detection. No other arrhythmias were considered in this study. The proposed algorithm requires no direct heartbeat peak detection from the SCG data, which makes it tolerant against interpersonal variations in the SCG morphology, and noise. Furthermore, the proposed method relies solely on the SCG and needs no complementary electrocardiography to be functional. For the considered data, the detection method performs well even on relatively low quality SCG signals. Using a majority voting scheme that takes five randomly selected segments from a signal and classifies these segments using the proposed algorithm, we obtained an average true positive rate of $\text{99.9}\%$ and an average true negative rate of $\text{96.4}\%$ for detecting AFib in leave-one-out cross-validation. This paper facilitates adoption of microelectromechanical sensor based heart monitoring devices for arrhythmia detection.
When You Become a Superman: Subliminal Exposure to Death-Related Stimuli Enhances Men’s Physical Force

Research based on terror management theory (TMT) has consistently found that reminders to individuals about their mortality engender responses aimed at shoring up faith in their cultural belief system. Previous studies have focused on the critical role that the accessibility of death-related thought plays in these effects. Moreover, it has been shown that these effects occur even when death-related stimuli are presented without awareness, suggesting the unconscious effects of mortality salience. Because one pervasive cultural ideal for men is to be strong, we hypothesized that priming death-related stimuli would lead to increasing physical force for men, but not for women. Building on self-escape mechanisms from TMT, we propose that the mechanism that turns priming of death-related stimuli into physical exertion relies on the co-activation of the self with death-related concepts. To test this hypothesis, we subjected 123 participants to a priming task that enabled us to combine the subliminal priming of death-related words with briefly presented self-related words. Accordingly, three different conditions were created: a (control) condition in which only self-related stimuli were presented, a (priming) condition in which death-related words were subliminally primed but not directly paired with self-related stimuli, and a (priming-plus-self) condition in which death-related words were subliminally primed and immediately linked to self-related stimuli. We recorded handgrip force before and after the manipulations. Results showed that male participants in the priming-plus-self condition had a higher peak force output than the priming and control conditions, while this effect was absent among female participants. These results support the hypothesis that unconscious mortality salience, which is accompanied with self-related stimuli, increases physical force for men but not for women. The gender difference may reflect the cultural belief system, in which individuals are taught that men should be strong. Thus, the unconscious mortality salience produced by exposure to the death-related stimuli motivates need to conform to this internalized cultural standard.
Anisotropic Sliding of Water Droplets on the Superhydrophobic Surfaces with Anisotropic Groove‐Like Micro/Nano Structures

Former studies have found that water droplets on the rice leaves exhibit anisotropic sliding behavior, which is mainly caused by the anisotropic groove‐like surface microstructures. Similar groove‐like surface microstructures and anisotropic sliding behavior of water droplets can also be found on some other plants, such as the reed leaves. In this paper, biomimetic groove‐like surface microstructures are fabricated on copper surfaces by femtosecond laser micromachining. Thanks to the flexibility of this method, the period and height of the periodic micro‐grooves can be precisely controlled, and the nanoscale surface roughness can also be regulated. The influences of these surface morphologies on the wetting state and anisotropic sliding behavior of water droplets are studied systematically, and theoretic analyses are also conducted. Our results prove that the anisotropic sliding behavior is mainly decided by the wetting state of external water droplets. Besides, plenty of surface nanostructures have no benefits to the anisotropic sliding behavior of surface water droplets.
Toward the Geoscience Paper of the Future: Best practices for documenting and sharing research from data to software to provenance

Geoscientists now live in a world rich with digital data and methods, and their computational research cannot be fully captured in traditional publications. The Geoscience Paper of the Future (GPF) presents an approach to fully document, share, and cite all their research products including data, software, and computational provenance. This article proposes best practices for GPF authors to make data, software, and methods openly accessible, citable, and well documented. The publication of digital objects empowers scientists to manage their research products as valuable scientific assets in an open and transparent way that enables broader access by other scientists, students, decision makers, and the public. Improving documentation and dissemination of research will accelerate the pace of scientific discovery by improving the ability of others to build upon published work.
Understanding Sociobehavioral Mitigators of Depressive Symptoms among U.S. Young Adults

This study drew upon an ecological system framework to examine a model focusing on the interrelationship among depressive symptoms, sense of mastery, moderate-to-vigorous physical activity (MVPA), religiosity, and relations with parents and romantic partners among U.S. young adults aged 24 to 34. Cross-sectional data from the National Longitudinal Study of Adolescent Health (N = 4,982), obtained in 2008 and 2009, were analyzed using structural equation modeling techniques. The associations of MVPA, relations with parents, and relations with romantic partner to depressive symptoms were mediated through mastery. Relations with one's romantic partner were a stronger predictor of depressive symptoms than relations with parents, while the influence of religiosity on relations with romantic partner was largely mediated by relations with parents. The results highlight the sociobehavioral buffers of depressive symptoms that are peculiar to young adulthood. Further intervention research in preventing and treating depressive symptoms should consider incorporating the sociobehavioral factors that are tailored to the specific age group.
Diagnosis, Risk Assessment, and Treatment Decisions for Occlusal Caries: A Survey from the Danish Public Dental Health Service

This study validates a case-based survey method and analyzes the extent to which Danish dental professionals apply current concepts and strategies for occlusal caries management in children, adolescents, and young adults. A case-based, precoded questionnaire consisting of 10 clinical cases/patients with 26 teeth/occlusal surfaces was developed. The cases were set up in a PowerPoint presentation and color printed as a booklet illustrating patients with different patterns of caries activity, severity, and risk. A total of 69 dental professionals participated. Content and face validity of the survey method was established using a panel of experts. The panel also assessed the reliability of the method using a test-retest procedure (κ ≥ 0.80) and acting as benchmark. Measurements of agreement between dental professional and benchmark assessments showed substantial agreement for overall caries activity and risk assessment of patients and for clinical and radiographic severity of occlusal lesions (κ = 0.61-0.67). For assessment of caries lesion activity on occlusal surfaces, the agreement was moderate (κ = 0.50). Regarding treatment decisions, dental professionals showed substantial agreement when indicating restorative treatments (κ = 0.68). Multivariate logistic regression analysis showed a significant influence of various patient-, lesion-, and participant-related variables in the assessment of caries risk, caries activity and severity, and treatment decision. In conclusion, Danish dental professionals participating in the study apply reasonably well current concepts on overall caries activity and risk assessment, clinical and radiographic severity of occlusal lesions, and, to a certain extent, assessment of caries lesion activity on occlusal surfaces. Nonoperative treatment decisions had a high priority among Danish professionals.
Pioglitazone Use and Risk of Bladder Cancer: an In Vitro Study

Aims: Whether pioglitazone (PIO), a peroxisome proliferator-activated receptor-gamma agonist, increases the risk of developing bladder cancer has been debated for several years. The aim of this study was to investigate the in vitro effects of PIO on normal urothelial transitional epithelium (NUTE) cells and bladder cancer (J82) cells to further evaluate the risk. Methods: NUTE cells were obtained from Sprague-Dawley rats. NUTE and J82 cells were treated with different concentrations of PIO for various time periods. Cell proliferation was tested by the MTT assay. Cell apoptosis was evaluated by flow cytometry. The expressions of p53, cyclin D1, Bcl-2, and Bax were determined by qRT-PCR and western blots. Results: After 24 hours, the treatment of NUTE cells with 10 μmol/L PIO led to morphological changes, without changes in J82 cells. Moreover, PIO inhibited the proliferation and induced apoptosis of NUTE cells, but not J82 cells, in a time- and dose-dependent manner. However, PIO did not alter the growth of cells from other tissues. In addition, treatment with PIO for up to 72 hours did not result in changes in the expressions of p53, cyclin D1, Bcl-2, and Bax in NUTE cells and J82 cells. Interestingly, PIO significantly downregulated the protein levels of p53 and cyclin D1 in J82 cells, but not NUTE cells after more than 192 hours of treatment. Conclusions: PIO did not promote malignant alterations of NUTE cells or stimulate proliferation of J82 cells. PIO decreased the expression of p53 and cyclin D1 in J82 cells after long-term culture, which suggested that PIO may be helpful for diabetic patients with bladder cancer.
Predicting Best Answerers for New Questions: An Approach Leveraging Distributed Representations of Words in Community Question Answering

Community Question Answering (CQA) sites are becoming an increasingly important source of information where users can share knowledge on various topics. Although these sites provide opportunities for users to seek for help or provide answers, they also bring new challenges. One of the challenges is most new questions posted everyday cannot be routed to the appropriate users who can answer them in CQA. That is to say, experts cannot receive questions that match their expertise. Therefore new questions cannot be answered in time. In this paper, we propose an approach which based on distributed representations of words to predict the best answerer for a new question on CQA sites. Our approach considers both user activity and user authority. The user activity and user authority are based on the previous questions answered by the user. We have applied our model on the dataset downloaded from StackOverflow, one of the biggest CQA sites. The results show that our approach performs better than the TF-IDF and Language Model based methods.
Can changes in resistance exercise workload influence internal load, countermovement jump performance and the endocrine response?

ABSTRACT This study examined the influence of differing volume load and intensity (%1 repetition maximum[%1RM]) resistance exercise workouts on session rating of perceived exertion (sRPE) countermovement jump (CMJ) performance and endocrine responses. Twelve participants performed a workout comprising four exercises (bench press, back squat, deadlift and prone bench pull) in randomised order as either power (POW); 3 sets × 6 repetitions at 45%1RM × 3 min inter-set rest, strength (ST); 3 sets × 3 repetitions at 90%1RM × 3 min inter-set rest, or hypertrophy (HYP); 3 sets × 10 repetitions at 70%1RM × 1 min inter-set rest in a randomised-crossover design. CMJ performance and endocrine responses were measured immediately pre-, post-, 12, 24, 48 and 72 h post-exercise. POW sRPE (3.0 ± 1.0) was lower than ST (4.5 ± 1.0) (P = 0.01), and both were lower than HYP (8.5 ± 1.0) (P = 0.01). Duration of CMJ decrement was longer (P ≤ 0.05) for HYP (72 h) compared to POW (12 h) and ST (24 h). Testosterone concentration was greater (P ≤ 0.05) immediately post-exercise in HYP compared to POW and ST. In conclusion, less inter-set rest, greater volume load and intensity (%1RM) may increase sRPE, duration of CMJ performance decrement and testosterone responses in resistance exercise.
RETREG1 (FAM134B): A new player in human diseases: 15 years after the discovery in cancer

FAM134B (family with sequence similarity 134, member B)/RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non‐functional expression of FAM134B protein impairs ER‐turnover and thereby is involved in the pathogenesis of some human diseases. FAM134B inhibition contributes to impair proteostasis in the ER due to the accumulation of misfolded or aggregated proteins, which in turn leads to compromised neuronal survival and progressive neuronal degenerative diseases. Mutations in FAM134B associated with hereditary sensory and autonomic neuropathy type IIB (HSAN IIB). Selective cleavage of FAM134B by Dengue, Zika, and West Nile virus encoded protease NS2B3 leads to the increased production of infection units, whereas upregulation of FAM134B inhibits viral replication. In cancer, FAM134B acts as a tumor suppressor and inhibit cancer growth both in‐vitro and in‐vivo. Pharmacological upregulation of FAM134B resulted in reduced cancer cell growth and proliferation. In addition, FAM134B mutations are common in patients with colorectal adenocarcinoma, and oesophageal squamous cell carcinoma. These mutations and expression changes of FAM134B were associated with the biological aggressiveness of these cancers. FAM134B also plays a role in allergic rhinitis, vascular dementia, and identification of stem cells. Taken together, information available in the literature suggests that FAM134B plays critical roles in human diseases, by interacting with different biological and chemical mediators, which are primarily regulated by ER turnover.
The Effect of Background Noise on the Word Activation Process in Nonnative Spoken-Word Recognition

This article investigates 2 questions: (1) does the presence of background noise lead to a differential increase in the number of simultaneously activated candidate words in native and nonnative listening? And (2) do individual differences in listeners’ cognitive and linguistic abilities explain the differential effect of background noise on (non-)native speech recognition? English and Dutch students participated in an English word recognition experiment, in which either a word’s onset or offset was masked by noise. The native listeners outperformed the nonnative listeners in all listening conditions. Importantly, however, the effect of noise on the multiple activation process was found to be remarkably similar in native and nonnative listening. The presence of noise increased the set of candidate words considered for recognition in both native and nonnative listening. The results indicate that the observed performance differences between the English and Dutch listeners should not be primarily attributed to a differential effect of noise, but rather to the difference between native and nonnative listening. Additional analyses showed that word-initial information was found to be more important than word-final information during spoken-word recognition. When word-initial information was no longer reliably available word recognition accuracy dropped and word frequency information could no longer be used suggesting that word frequency information is strongly tied to the onset of words and the earliest moments of lexical access. Proficiency and inhibition ability were found to influence nonnative spoken-word recognition in noise, with a higher proficiency in the nonnative language and worse inhibition ability leading to improved recognition performance.
Quality of reporting of randomized clinical trials in abstracts of the 2005 annual meeting of the American College of Rheumatology.

OBJECTIVE To determine the quality of abstracts reporting randomized clinical trials (RCT) at the 2005 Annual Scientific Meeting of the American College of Rheumatology. METHODS All 2005 abstracts including late-breaking abstracts were assessed. An abstract was deemed to be reporting an RCT if it indicated that participants were randomized in the title or body of the abstract. RCT were excluded if they included only pharmacokinetic data. The CONSORT checklist was applied and relevant data extracted. We defined manufacturer support as acknowledgment of industry support or industry employee as co-author. RESULTS Of 2146 abstracts, 143 (6.7%) reported RCT. Of these, 78.3% were drug trials, and 63.6% indicated manufacturer support. Only 30.8% of abstracts used "randomized" in the title, 44.1% did not explicitly state whether blinding was undertaken, and only 7.0% clearly stated who was blinded. Thirty percent of studies did not give an explicit definition of eligibility criteria of participants. While 84.6% explicitly described the experimental intervention, only 37.1% explicitly described the comparator intervention. Only 21% explicitly stated that an intention to treat analysis was performed. Baseline demographic and clinical characteristics were reported in 48.3%. While most abstracts reported summary results for each treatment group, only 35.7% reported effect size with its precision. CONCLUSION The quality of reporting is suboptimal in many RCT abstracts. Abstracts reporting RCT would benefit from a structured approach that ensures more detailed reporting of eligibility criteria, active and comparator interventions, flow of participants, and adequate summary and precision of results.
Epidemiology of Huntington disease in Cyprus: A 20‐year retrospective study

Huntington disease (HD) is most prevalent among populations of western European descent and isolated populations where founder effects may operate. The aim of this study was to examine the epidemiology of HD in Cyprus, an island in southern Europe with extensive western European colonization in the past. All registered HD patients in the Cyprus, since 1994, were included. Detailed pedigrees and clinical information were recorded and maps, showing the geographic distribution of HD, were constructed. Requests for genetic testing were also examined. The project identified 58 clinically manifested cases of HD belonging to 19 families. The 16 families of Cypriot origin were concentrated in a confined geographical cluster in southeast Cyprus. In 2015, prevalence of symptomatic HD was 4.64/100 000 population, while incidence was 0.12/100 000 person‐years. Prevalence displayed a marked increase during the past 20 years. Disease characteristics of HD patients were similar to those reported in western European populations. Lastly, the uptake of predictive and/or prenatal testing was limited. HD disease characteristics, incidence and prevalence in Cyprus were comparable to western European populations. Together with the geographical clustering observed, these results support the possibility for a relatively recent founder effect of HD in Cyprus, potentially of western European origin.