Miracle-dz/UniFAR-FTUs huggingface dataset:
PERSONALITY PROCESSES AND INDIVIDUAL DIFFERENCES Who Knows What About a Person ? The Self – Other Knowledge Asymmetry ( SOKA ) Model

This article tests a new model for predicting which aspects of personality are best judged by the self and which are best judged by others. Previous research suggests an asymmetry in the accuracy of personality judgments: Some aspects of personality are known better to the self than others and vice versa. According to the self–other knowledge asymmetry (SOKA) model presented here, the self should be more accurate than others for traits low in observability (e.g., neuroticism), whereas others should be more accurate than the self for traits high in evaluativeness (e.g., intellect). In the present study, 165 participants provided self-ratings and were rated by 4 friends and up to 4 strangers in a round-robin design. Participants then completed a battery of behavioral tests from which criterion measures were derived. Consistent with SOKA model predictions, the self was the best judge of neuroticism-related traits, friends were the best judges of intellect-related traits, and people of all perspectives were equally good at judging extraversionrelated traits. The theoretical and practical value of articulating this asymmetry is discussed.
Association between Neck/Shoulder Pain and Trapezius Muscle Tenderness in Office Workers

Background. Neck/shoulder pain is a common musculoskeletal disorder among adults. The pain is often assumed to be related to muscular tenderness rather than serious chronic disease. Aim. To determine the association between neck/shoulder pain intensity and trapezius muscle tenderness in office workers. Methods. 653 employees from two large office workplaces in Copenhagen, Denmark, replied to a questionnaire on health and working conditions (mean: age 43 years, body mass index 24 kg·m−2, computer use 90% of work time, 73% women). Respondents rated intensity of neck/shoulder pain during the previous three months on a scale of 0–10 and palpable tenderness of the upper trapezius muscle on a scale of “no tenderness,” “some tenderness,” or “severe tenderness. ” Odds ratios for tenderness as a function of neck/shoulder pain intensity were determined using cumulative logistic regression controlled for age, gender, and chronic disease. Results. The prevalence of “no,” “some,” and “severe” tenderness of the trapezius muscle was 18%, 59%, and 23% in women and 51%, 42%, and 7% in men, respectively (chi-square, P < 0.0001). Participants with “no,” “some,” and “severe” tenderness of the trapezius muscle, respectively, rated their neck/shoulder pain intensity to 1.5 (SD 1.6), 3.8 (SD 2.0), and 5.7 (SD 1.9) for women and 1.4 (SD 1.4), 3.1 (SD 2.2), and 5.1 (SD 1.7) for men. For every unit increase in neck/shoulder pain intensity, the OR for one unit increase in trapezius tenderness was 1.86 (95% confidence interval 1.70 to 2.04). Conclusion. In office workers, a strong association between perceived neck/shoulder pain intensity and trapezius muscle tenderness exists. The present study provides reference values of pain intensity among office workers with no, some, and severe tenderness of the trapezius muscle.
Skills, Strategies, and Outcomes of Successful Mentor Teachers.

This study examines the role of effective mentor teachers by analyzing the strategies and skills they used, the obstacles and problems they encountered, and the outcomes they achieved. Data for five case studies were collected from five elementary mentor teachers, their proteges, and their principals--participants in the Oregon Beginning Teacher Support Program. Interviews and questionnaires were the sources of the data. Collaborative problem solving was the strategy most used by the mentors, followed by emotional support, energizing and motivating, and demonstration/modeling. Skills successfully used by the mentors included the social process skill of interpersonal ease, listening, knowledge of educational content, demonstration/modeling, and confidence-building. Team match and empathy for the protege were the chief sources of support for mentors, while increased professional growth ranked as the highest sources of satisfaction. The major impediment to the mentoring process was lack of time. Informants indicated that the major outcomes of the mentor program were a satisfactory relationship between mentor and protege and satisfaction with the program. (IAH) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** Skills, Strategies, and Outcomes of Successful Mentor Teachers "PERMISSION TO REPRODUCE THIS MATERIAL HAS BEEN GRANTED BY TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC). " Blaine Ackley University of Portland M. D. Gall University of Oregon U DEPARTMENT OF EDUCATION Otke I Educettonot Rose Itcn iktsci teotovement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) th,s (socument his been reproduced iS ,ece.ved from the person of orpanual.on rgroatrnp .1 Mnot changes have been made to .mprOve taprOdUCtion quality Pptnts pl vte,s, o opnetons stated fl (h.s Po( u mem Op not necessar OS represent olt.c.al OE SI) POSr ln Or potcy Paper presented at the annual meeting of the American Educational Research Association, San Francisco, April, 1992.
AUDIT: Stress Testing the Automatic Way

Sudden variations in current (large di/dt) can lead to significant power supply voltage droops and timing errors in modern microprocessors. Several papers discuss the complexity involved with developing test programs, also known as stress marks, to stress the system. Authors of these papers produced tools and methodologies to generate stress marks automatically using techniques such as integer linear programming or genetic algorithms. However, nearly all of the previous work took place in the context of single-core systems, and results were collected and analyzed using cycle-level simulators. In this paper, we measure and analyze di/dt issues on state-of-the-art multi-core x86 systems using real hardware rather than simulators. We build on an existing single-core stress mark generation tool to develop an Automated DI/dT stress mark generation framework, referred to as AUDIT, to generate di/dt stress marks quickly and effectively for multicore systems. We showcase AUDIT's capabilities to adjust to micro architectural and architectural changes. We also present a dithering algorithm to address thread alignment issues on multi-core processors. We compare standard benchmarks, existing di/dt stress marks, and AUDIT-generated stress marks executing on multi-threaded, multi-core systems with complex out-of-order pipelines. Finally, we show how stress analysis using simulators may lead to flawed insights about di/dt issues.
Circadian rest-activity disturbances in children with seasonal affective disorder.

OBJECTIVE Seasonal affective disorder (SAD) affects from 1.7% to 5.5% of children. Previous studies found that nonseasonally depressed children had a blunted circadian rhythm, while adults with SAD had a delayed and poorly entrained rhythm. The purpose of this study was to determine whether pediatric SAD more closely resembles nonseasonal pediatric depression or adult SAD. METHOD Twelve normal, healthy volunteers (11.6 +/- 3.7 years; 6 female, 6 male) and 14 unmedicated children with SAD (11.0 +/- 3.3 years; 9 female, 5 male) meeting Rosenthal/NIMH criteria for SAD and Schedule for Affective Disorders and Schizophrenia for School-Age Children-Epidemiologic version criteria for major depression had their levels of activity recorded for 72 hours (weekdays) using belt-worn actigraphs. RESULTS The SAD group had blunted circadian amplitudes that were 10% lower than normal (p = .004). They were more poorly modeled by the standard cosinor equation (p = .001), and a circadian rhythm accounted for 39% less of the variability in their activity profile (p = .007). The amplitude of the 12-hour harmonic rhythm was markedly increased. There were no differences between SAD and control children in the timing of the circadian rhythm and degree of entrainment. CONCLUSIONS Children with SAD displayed dysregulated circadian activity rhythms comparable with those reported in nonseasonally depressed children, yet different from those observed in adults.
Impact of Acute Intermittent Exercise on Natural Killer Cells in Breast Cancer Survivors

Background. Current research examining the effect of exercise on immune responses in cancer survivors is limited. Objective. The aim of this pilot study was to examine the effect of 1 bout of intermittent exercise on natural killer (NK) cell numbers in breast cancer survivors. Methods. A total of 9 women with stage I to III invasive breast cancer who were 3 to 6 months posttreatment and 9 sedentary women without a history of cancer completed 10 three-minute intervals of aerobic exercise on the cycle ergometer at 60% of VO2peak (peak oxygen uptake). Whole blood samples were taken pre-exercise, immediately postexercise, and at 2 hours and 24 hours postexercise. NK cell counts were assessed using flow cytometry. Results. In both groups, NK cell counts significantly increased immediately postexercise compared with pre-exercise (P = .004-.008) and returned to near pre-exercise levels during recovery (P = .129-.547). Absolute NK cell counts were significantly lower in breast cancer survivors immediately postexercise when compared with controls (P = .046). Conclusions. The breast cancer survivor group exhibited NK cell responses to 30 minutes of moderate-intensity intermittent aerobic exercise that were comparable with that in the group of physically similar women without a history of cancer. Immune changes related to cancer treatments may be related to the lower absolute NK cell counts observed in the breast cancer survivor group. Although the results of this study are preliminary in nature, they suggest that this type of exercise does not disrupt this aspect of innate immunity in recent breast cancer survivors, thereby supporting current exercise recommendations for this population.
Molecular and Cellular Pathobiology Inactivation of the Dlc 1 Gene Cooperates with Downregulation of p 15 INK 4 b and p 16 Ink 4 a , Leading to Neoplastic Transformation and Poor Prognosis in Human Cancer

The tumor suppressor gene deleted in liver cancer-1 (DLC1), which encodes a protein with strong RhoGAP (GTPase activating protein) activity and weak Cdc42GAP activity, is inactivated in various human malignancies. Following Dlc1 inactivation, mouse embryo fibroblasts (MEF) with a conditional Dlc1 knockout allele reproducibly underwent neoplastic transformation. In addition to inactivation ofDlc1 and increased activity of Rho and Cdc42, transformation depended on the subsequent decreased expression of the Cdk4/6 inhibitors p15 and p16 together with increased expression and activation of Cdk4/6. The level of expression of these cell-cycle regulatory genes was relevant to human tumors with low DLC1 expression. Analysis of publicly available annotated datasets of lung and colon cancer with gene expression microarray profiles indicated that, in pairwise comparisons, low DLC1 expression occurred frequently together (P < 0.01) with downregulation of p15 or p16 or upregulation ofCDK4 orCDK6. In addition, an unfavorable prognosis (P< 0.05) was associatedwith low DLC1 and low p15 in lung cancer and colon cancer, low DLC1 and low p16 in lung cancer, low DLC1 and high CDK4 in lung cancer, and low DLC1 and high CDK6 in colon cancer. Thus, several genes and biochemical activities collaborate with the inactivation of DLC1 to give rise to cell transformation in MEFs, and the identified genes are relevant to human tumors with low DLC1 expression. Cancer Res; 72(22); 5900–11. 2012 AACR.
The Feeling of Being Stared at: A Parapsychological Classic with a Facelift

Abstract Findings in parapsychology suggest an effect of distant intentionality related to remote staring. Previously, either the covariation of a distant gaze with the electrodermal activity (EDA) of the person being observed (staree) or with the person’s conscious guesses are measured. We combined these two strands of research. Thereby we allowed for the starees at any time to indicate whether they felt being stared at or not. We distracted the starers by a demanding mental task in half of the sessions or we instructed them to keep their minds busy with anything but the staree. Overall 50 sessions were conducted. The experiment failed to demonstrate a clear cut effect. The difference between the staring and non-staring conditions was not significant. For the comparison of distraction and standard procedures we found no significant differences for EDA or conscious report. However in a post hoc analysis one of the conscious report variables approached significance for the interaction between staring and distraction in the predicted direction. The effect size of the staring effect in this condition was d = 0.57. We conclude that the starer’s mental strategy during the non-staring periods may be important.
Phase II study of oxaliplatin plus S-1 as first-line treatment for advanced gastric cancer (G-SOX study).

BACKGROUND The efficacy and safety of oxaliplatin combined with S-1 (SOX regimen) for unresectable advanced or recurrent gastric cancer were investigated. PATIENTS AND METHODS Oxaliplatin was administered i.v. (100 mg/m(2)) on day 1, while S-1 was administered orally (80 mg/m(2)/day, b.i. d. ) for 14 days followed by a 7-day rest. This schedule was repeated every 3 weeks. RESULTS Among 55 patients enrolled, one patient received oxaliplatin for the other study, and three patients were considered unsuitable against the inclusion criteria. Accordingly, 51 patients were assessable for efficacy. The response rate was 59%, and the disease control rate was 84%. The median progression-free survival time was 6.5 months, the 1-year survival rate was 71%, and the median survival time was 16.5 months. In 54 patients assessed for safety, the major grade 3/4 toxic effects were neutropenia (22%), thrombocytopenia (13%), anemia (9%), anorexia (6%), fatigue (6%), and sensory neuropathy (4%). CONCLUSION These findings indicate that SOX regimen with oxaliplatin at a dose of 100 mg/m(2) is feasible and shows promising efficacy against advanced gastric cancer.
Estimation of Polder Retention Capacity Based on ASTER, SRTM and LIDAR DEMs: The Case of Majdany Polder (West Poland)

This study compares four digital elevation models (DEMs), based on various data sources, to define polder retention capacities. Two commercial and two publically available, free of charge data sources were used. Commercial sources are DEMs based on aerial images and LIDAR (Light Detection and Ranging) data. Free data source DEMs generated are based on: SRTM (Shuttle Radar Topography Mission) and ASTER GDEM (ASTER Global Digital Elevation Model). In addition, the impact of the spatial resolution of the numerical terrain model on the calculated polder volume was evaluated. A DEM based on LIDAR data was used as the reference model and was supplemented with our own geodetic GPS (Global Positioning System) measurements. In flood modeling and management, including retention of river valleys and polders, it is necessary to properly estimate their capacity and the relation between capacity and water level. The study showed the impact of quantitative and qualitative data sources in determining the retention capacity of a polder.
Multivariate analysis including biomarkers in the phase III RADIANT-2 study of octreotide LAR plus everolimus (E+O) or placebo (P+O) among patients with advanced neuroendocrine tumors (NET).

157 Background: In this large phase III trial, median progression-free survival (PFS) improved by 5.1 mo with E+O compared to P+O in patients (pts) with NET associated with carcinoid syndrome. Randomization imbalances including WHO performance status (PS), and primary site favoring P+O confounded primary analysis. Chromogranin A (CgA) and 5-hydroxyindoleacetic acid (5-HIAA) are important biomarkers in NET. Analyses were performed to identify prognostic factors and adjust for randomization imbalances. METHODS Pts were randomized to E+O (n=216) or P+O (n=213). Potential prognostic factors including baseline CgA (≤2×ULN vs >2×ULN), baseline 5-HIAA (≤median vs >median), age (<65 vs ≥65), gender, race, WHO PS (0 vs 1, 2), primary site (lung vs other), prior somatostatin analog use (yes vs no), duration from diagnosis (<6 mo, 6-24 mo, 2-5 yr, >5 yr), and organs involved (liver, bone) were assessed in univariate analysis using the log rank test and a stepwise regression using Cox proportional hazards model. RESULTS Randomization resulted in significant imbalance in baseline CgA (median [ng/mL], 251 E+O vs 137 P+O). Median PFS (mo) was significantly longer for pts with nonelevated CgA (27 vs 11; P<.001) and nonelevated 5-HIAA (17 vs 11; P<.001). Analyses also indicated age (14 vs 12; P=.01), WHO PS (17 vs 11; P=.004), liver involvement (14 vs not reached; P=.02), bone metastases (8 vs 15; P<.001), and lung as primary site (11 vs 14; P=.06) as potentially prognostic. Multivariate analysis indicated that significant prognostic factors for PFS included baseline CgA (HR, 0.47; CI, 0.34-0.65; P<.001), WHO PS (HR, 0.69; CI, 0.52-0.90; P=.006), bone involvement (HR, 1.52; CI, 1.06-2.18; P=.02), and lung as primary site (HR, 1.55; CI, 1.01-2.36; P=.04). Adjusted for covariates, a 38% reduction in risk of progression was observed for E+O (HR, 0.62; 95% CI, 0.51-0.87; P=.003). CONCLUSIONS In the phase III RADIANT-2 trial, baseline CgA levels, WHO PS, lung as primary site, and bone involvement were important prognostic factors. Exploratory analysis adjusted for these prognostic factors indicated significant benefit for everolimus therapy.
Clinical pharmacology of gentamicin in neonates: regimen, toxicology and pharmacokinetics

Gentamicin is an aminoglycoside antibiotic. It kills bacteria by inhibiting protein synthesis and to some extent by lysing the cell envelope. Gentamicin is frequently the first choice drug because of its reliability, but also because of the long experience with its use. In combination with β-lactam antibiotics it is recommended for the treatment of sepsis or pneumonia and is active against P. aeruginosa, Enterobacter, Klebsiella and Serratia. However, gentamicin is ototoxic and nephrotoxic. The human mitochondrial genetic variant m.1555A > G has been reported to be an important cause of non-syndromic hereditary hearing dysfunction and may cause permanent hearing loss. Even short courses of gentamicin therapy in healty newborn infants can lead to abnormalities of auditory function. It is active against very resistant bacteria at peak concentrations (> 10 mg/l) that are high enough to be potentially toxic. For safe therapeutic efficacy, peak plasma concentrations of gentamicin should range from 4 to 10 mg/l; but trough concentrations, immediately before a new drug administration, must be lower that 2 mg/L to avoid toxic effects. Pharmacokinetic parameters vary considerably in infants. Half-life ranges from 5.4 to 10.0 hours, clearance 0.50 to 1.71 ml/h/kg and distribution volume from 0.4 to 0.7 l/kg. Preterm infants have a longer half-life than full-term infants. Thus, it is mandatory to monitor gentamicin serum concentrations whenever infants are treated for 48 hours or more.
User mobility from the view of cellular data networks

Understanding the user mobility is essential to resource optimization and algorithm evaluation in mobile networks, such as network planning, content distribution, and evaluation of hand-over mechanisms. Existing human mobility models focus on extracting mobility patterns from Call Detail Records (CDRs) or WiFi traces. While the former only captures movements during phone calls, the latter does not provide direct answers to mobility of cellular network users in a large scale. In this paper, we take the first step to investigate if the mobility properties derived from cellular data traffic is different from the previous findings using other data source, especially the commonly used CDR based approach. We present a comprehensive characterization of the mobility patterns from the cellular data networks' perspective, using a set of systematic methods. We find that the data network records can provide finer granularity of location and movement information. Three different temporal movement patterns are identified. Furthermore, we propose a new method for predicting future application usage given the mobility patterns and show promising results.
Efficient labeling in vitro with non-ionic gadolinium magnetic resonance imaging contrast agent and fluorescent transfection agent in bone marrow stromal cells of neonatal rats

Although studies have been undertaken on gadolinium labeling-based molecular imaging in magnetic resonance imaging (MRI), the use of non-ionic gadolinium in the tracking of stem cells remains uncommon. To investigate the efficiency in tracking of stem cells with non-ionic gadolinium as an MRI contrast agent, a rhodamine-conjugated fluorescent reagent was used to label bone marrow stromal cells (BMSCs) of neonatal rats in vitro, and MRI scanning was undertaken. The fluorescent-conjugated cell uptake reagents were able to deliver gadodiamide into BMSCs, and cell uptake was verified using flow cytometry. In addition, the labeled stem cells with paramagnetic contrast medium remained detectable by an MRI monitor for a minimum of 28 days. The present study suggested that this method can be applied efficiently and safely for the labeling and tracking of bone marrow stromal cells in neonatal rats.
The impact of immigration detention on the mental health of torture survivors is poorly documented--a systematic review.

INTRODUCTION Torture has enduring mental and physical health consequences for survivors. Detention of asylum seekers is an integrated part of the immigration systems in many countries. Among the asylum seekers are vulnerable groups such as survivors of torture and severely traumatized refugees. The aim of the present study is to review the scientific evidence on the mental health consequences of immigration detention for adult survivors of torture. METHODS The review was conducted according to a modified version of the PRISMA guidelines. A systematic search was made in: PubMed (Medline), PsychINFO, PILOTS and IBSS, and reference lists were screened. RESULTS The search yielded 241 results and two records came from additional sources. A total of 15 studies were included. Merely two case studies focused on survivors of torture. Both reported severe effects of detention on the detainees' mental health. High levels of psychological problems were found in studies identifying torture survivors among the asylum seekers. CONCLUSION The impact of detention on the mental health of torture survivors is poorly documented, and the available data are insufficient to allow analysis of any specific effects. The studies do report severe mental health issues among detained torture survivors. In general, serious mental health problems are found among the detainees and formerly detained asylum seekers. Systematically identifying torture survivors and other vulnerable groups, and assessing and monitoring mental health issues is crucial. The health risks that detention may pose to the wellbeing of each individual should be carefully considered.