Miracle-dz/UniFAR-FTUs huggingface dataset:
Vaginal infections in pregnant women in Jamaica: prevalence and risk factors

Trichomoniasis, bacterial vaginosis (BV) and candidiasis are reproductive tract infections (RTIs) of the vagina. We conducted a cross-sectional study in 4 prenatal clinics in Kingston, Jamaica, to estimate the prevalence of these infections and the risk factors that may facilitate their transmission among pregnant women. Of the 269 women studied, 18.0% had culture-positive trichomoniasis, 44.1% had BV (Nugent score 7) and 30.7% were positive for candidiasis by wet mount. A multiple logistic regression analysis showed that having a malodorous discharge was associated with trichomoniasis (odd ratios [OR]=3.9, confidence intervals [CI]=1.04-14.7) and BV (OR=3.4, CI=1.3-8.7). Women who took action to prevent HIV infection had lower BV prevalence (OR=0.34, CI=0.12-0.98). Women who were employed were less likely to have any of the infections (OR=0.61, CI=0.36-1.03). The strong association of a symptomatic presentation with trichomoniasis and BV suggests the merit of considering syndromic management of vaginitis in this population.
The 6D Bias and the Equity-Premium Puzzle

If decision costs lead agents to update consumption every D periods, then econometricians will find an anomalously low correlation between equity returns and consumption growth (Lynch, 1996). We analytically characterize the dynamic properties of an economy composed of consumers who have such delayed updating. In our setting, an econometrician using an Euler equation procedure would infer a coefficient of relative risk aversion biased up by a factor of 6D. Hence with quarterly data, if agents adjust their consumption every D=4 quarters, the imputed coefficient of relative risk aversion will be 24 times greater than the true value. High levels of risk aversion implied by the equity premium and violations of the Hansen-Jagannathan bounds cease to be puzzles. The neoclassical model with delayed adjustment explains the consumption behavior of shareholders. Once limited participation is taken into account, the model matches most properties of aggregate consumption and equity returns, including new evidence that the covariance between ln$(C_{t+h}/C_{t})$ and $R_{t+1}$ slowly rises with h.
Toroidal and reductive Borel-Serre compactifications of locally symmetric spaces

By "Hermitian locally symmetric space" we mean an arithmetic quotient of a bounded symmetric domain. Both the toroidal and the reductive Borel-Serre compactifications of such a space come equipped with canonical mappings to the Baily-Borel Satake compactification. In this article we show that there is a mapping from the toroidal compactification to the reductive Borel-Serre compactification, whose composition with the projection to the Baily-Borel compactification agrees with the canonical projection up to an arbitrarily small homotopy. We also consider arithmetic quotients of a self-adjoint homogeneous cone. There is a canonical mapping from the reductive Borel-Serre compactification to the standard compactification of such a locally symmetric cone. We show that this projection, when restricted to the closure of a polyhedral cone, has contractible fibers.
Interrelated Roles for the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor-1α in the Immune Response to Infection

Cells of the immune system utilize multiple mechanisms to respond to environmental signals and recent studies have demonstrated roles for two closely related proteins, the aryl hydrocarbon receptor (AHR) and hypoxia inducible factor-1α (HIF1α), in these processes. The AHR is a transcription factor that is activated by diverse ligands found in the diet and environmental pollution as well as by microbial and host-derived products. In contrast, HIF1α is a transcription factor that is active under low oxygen conditions and mediates cellular responses to hypoxia. These evolutionarily conserved proteins have roles in the interrelated processes of metabolism, tumorigenesis, and vascular development. Additionally, the AHR and HIF1α have multiple effects on innate and adaptive immunity. This article provides an overview of the biology of these transcription factors and reviews the effects of AHR and HIF1α signaling on immunity to infection. There are many parallels between these two pathways and their functions highlight the importance of AHR and HIF1α activity particularly at barrier surfaces in coordinating responses to pathogens.
SwellShark: A Generative Model for Biomedical Named Entity Recognition without Labeled Data

We present SwellShark, a framework for building biomedical named entity recognition (NER) systems quickly and without hand-labeled data. Our approach views biomedical resources like lexicons as function primitives for autogenerating weak supervision. We then use a generative model to unify and denoise this supervision and construct large-scale, probabilistically labeled datasets for training high-accuracy NER taggers. In three biomedical NER tasks, SwellShark achieves competitive scores with state-of-the-art supervised benchmarks using no hand-labeled training data. In a drug name extraction task using patient medical records, one domain expert using SwellShark achieved within 5.1% of a crowdsourced annotation approach -- which originally utilized 20 teams over the course of several weeks -- in 24 hours.
Rape Prevention Through Empowerment of Adolescent Girls

BACKGROUND AND OBJECTIVE: Sexual assault is a major cause of injury, unplanned pregnancy, HIV infection, and mental health problems worldwide. In parts of sub-Saharan Africa, sexual assault has reached epidemic proportions. This study evaluated the efficacy of an empowerment and self-defense intervention for adolescent girls to decrease the incidence of sexual assault and harassment in Nairobi’s large informal settlements. METHODS: A prospective cohort of 1978 adolescents from 4 neighborhoods near Nairobi were taught empowerment, deescalation, and self-defense skills in six 2-hour sessions. The standard-of-care (SOC) group (n = 428) received a life skills class. Self-reported, anonymous survey data were collected at baseline and 10.5 months after intervention. RESULTS: Annual sexual assault rates decreased from 17.9/100 person-years at baseline to 11.1 at follow-up (rate ratio = 1.61; 95% confidence interval [CI], 1.26–1.86; P < .001); there was no significant change in the SOC group (14.3 to 14.0, rate ratio = 1.02; 95% CI, 0.67–1.57, P = .92). Sexual assault disclosure in the intervention group increased from 56% to 75% (P = .006), compared with a constant incidence of disclosure (53%) in the SOC group. The majority (52.3%) of adolescents in the intervention group reported using skills learned to stop an assault. CONCLUSIONS: This intervention decreased sexual assault rates among adolescent girls in Kenya. The intervention was also associated with an increase in the disclosure of assaults, thereby enabling survivors to seek care and support and possibly leading to the identification and prosecution of perpetrators. This model should be adaptable to other settings both in Africa and globally.
Cross-Layer Multi-Cloud Real-Time Application QoS Monitoring and Benchmarking As-a-Service Framework

Cloud computing provides on-demand access to affordable hardware (e.g., multi-core CPUs, GPUs, disks, and networking equipment) and software (e.g., databases, application servers and data processing frameworks) platforms with features such as elasticity, pay-per-use, low upfront investment and low time to market. This has led to the proliferation of business critical applications that leverage various cloud platforms. Such applications hosted on single/multiple cloud provider platforms have diverse characteristics requiring extensive monitoring and benchmarking mechanisms to ensure run-time Quality of Service (QoS) (e.g., latency and throughput). This paper proposes, develops and validates CLAMBS—Cross-Layer Multi-Cloud Application Monitoring and Benchmarking as-a-Service for efficient QoS monitoring and benchmarking of cloud applications hosted on multi-clouds environments. The major highlight of CLAMBS is its capability of monitoring and benchmarking individual application components such as databases and web servers, distributed across cloud layers (*-aaS), spread among multiple cloud providers. We validate CLAMBS using prototype implementation and extensive experimentation and show that CLAMBS efficiently monitors and benchmarks application components on multi-cloud platforms including Amazon EC2 and Microsoft Azure.
Why We Need New Evaluation Metrics for NLG

The majority of NLG evaluation relies on automatic metrics, such as BLEU . In this paper, we motivate the need for novel, system- and data-independent automatic evaluation methods: We investigate a wide range of metrics, including state-of-the-art word-based and novel grammar-based ones, and demonstrate that they only weakly reflect human judgements of system outputs as generated by data-driven, end-to-end NLG. We also show that metric performance is data- and system-specific. Nevertheless, our results also suggest that automatic metrics perform reliably at system-level and can support system development by finding cases where a system performs poorly.
Role of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse

Mechanical loading on pelvic supports contributes to pelvic organ prolapse (POP). However, the underlying mechanisms remain to be elucidated. Our previous study identified that mechanical strain induced oxidative stress (OS) and promoted apoptosis and senescence in pelvic support fibroblasts. The aim of the present study is to investigate the molecular signaling pathway linking mechanical force with POP. Using a four-point bending device, human uterosacral ligament fibroblasts (hUSLF) were exposed to mechanical tensile strain at a frequency of 0.3 Hz and intensity of 5333 µε, in the presence or absence of LY294002. The applied mechanical strain on hUSLF resulted in apoptosis and senescence, and decreased expression of procollagen type I α1. Mechanical strain activated phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt signaling and resulted in downregulated expression of glutathione peroxidase 1 and Mn-superoxide dismutase, and accumulation of intracellular reactive oxygen species. These effects were blocked by administration of LY294002. Furthermore, it was demonstrated that PI3K/Akt was activated in the uterosacral ligaments of POP patients, and that OS was increased and collagen type I production reduced. The results from the present study suggest that mechanical strain promotes apoptosis and senescence, and reduces collagen type I production via activation of PI3K/Akt-mediated OS signaling pathway in hUSLF. This process may be involved in the pathogenesis of POP as it results in relaxation and dysfunction of pelvic supports.
Transient Humidity Measurements—Part I: Sensor Calibration and Characteristics

In this paper, a transient test facility is used to investigate the transient response of a polymer film electronic humidity sensor (capacitance type) following a step change in humidity and temperature. The response of the humidity sensor is measured for a step change in the humidity with and without a change in temperature, and the data are correlated with exponential functions with two time constants. The major time constant of the sensor is about 3 s for the isothermal test but increases by an order of magnitude when the sensor is exposed to a simultaneous change in temperature and humidity
Polyamines as olfactory stimuli in the goldfish Carassius auratus

SUMMARY Electrophysiological responses of goldfish olfactory receptor neurons (ORNs) and goldfish behavioral responses to polyamines were investigated in vivo. Electro-olfactogram (EOG) recordings indicated that polyamines (putrescine, cadaverine and spermine) are potent olfactory stimuli for goldfish with estimated electrophysiological thresholds of 10–8–10–7 mol l–1, similar to that for L-arginine, the most stimulatory amino acid. Although thresholds were similar, the magnitude of the EOG responses to intermediate (10–5–10–4 mol l–1) and high (10–3 mol l–1) concentrations of polyamines dwarfed the responses to amino acids and related single amine containing compounds (amylamine and butylamine). The EOG responses to 0.1 mmol l–1 putrescine, cadaverine and spermine were, respectively, 4.2×, 4.3× and 10.3× the response of the standard, 0.1 mmol l–1 L-arginine. Electrophysiological cross-adaptation experiments indicated that polyamine receptor sites are independent from those to L-amino acids (alanine, arginine, glutamate, lysine, methionine and ornithine), bile salts (sodium taurocholate and taurolithocholate), the single amine containing compounds (amylamine and butylamine) and ATP. Further, the cross-adaptation experiments revealed the existence of independent receptor sites for the different polyamines tested. Pharmacological experiments suggested that polyamine odorant transduction does not primarily involve the cyclic AMP and IP3 second messenger pathways. Behavioral assays indicated that polyamines are attractants that elicit feeding behavior similar to that elicited by L-amino acids.
Patients with Temporoparietal Ictal Symptoms and Inferomesial EEG Do Not Benefit from Anterior Temporal Resection

Summary: Purpose: The role of posterior structural lesions leading to inadequate results after inferomesial temporal resection is well recognized. Here we present poor surgical outcome in six patients with nonlesional intractable epilepsy, well‐defined focal anterior and inferomesial temporal epileptic discharges, and posterior temporoparietal symptoms.
Pull-based data broadcast with dependencies: be fair to users, not to items

Broadcasting is known to be an efficient means of disseminating data in wireless communication environments (such as Satellite, mobile phone networks,.). It has been recently observed that the average service time of broadcast systems can be considerably improved by taking into consideration existing correlations between requests. We study a pull-based data broadcast system where users request possibly overlapping sets of items; a request is served when all its requested items are downloaded. We aim at minimizing the average user perceived latency, i.e. the average flow time of the requests. We first show that any algorithm that ignores the dependencies can yield arbitrary bad performances with respect to the optimum even if it is given arbitrary extra resources. We then design a (4 + ε)-speed O(1 + 1/ε2)-competitive algorithm for this setting that consists in 1) splitting evenly the bandwidth among each requested set and in 2) broadcasting arbitrarily the items still missing in each set into the bandwidth the set has received. Our algorithm presents several interesting features: it is simple to implement, non-clairvoyant, fair to users so that no user may starve for a long period of time, and guarantees good performances in presence of correlations between user requests (without any change in the broadcast protocol). We also present a (4 + ε)-speed O(1 + 1/ε3)-competitive algorithm which broad-casts at most one item at any given time and preempts each item broadcast at most once on average. As a side result of our analysis, we design a competitive algorithm for a particular setting of non-clairvoyant job scheduling with dependencies, which might be of independent interest.1
Applicability and Results of Maastricht Type 2 Donation After Cardiac Death Liver Transplantation

Maastricht type 2 donation after cardiac death (DCD) donors suffer sudden and unexpected cardiac arrest, typically outside the hospital; they have significant potential to expand the donor pool. Herein, we analyze the results of transplanted livers and all potential donors treated under our type 2 DCD protocol. Cardiac arrest was witnessed; potential donors arrived at the hospital after attempts at resuscitation had failed. Death was declared based on the absence of cardiorespiratory activity during a 5‐min no‐touch period. Femoral vessels were cannulated to establish normothermic extracorporeal membrane oxygenation, which was maintained until organ recovery. From April 2002 to December 2010, there were 400 potential donors; 34 liver transplants were performed (9%). Among recipients, median age, model for end‐stage liver disease and cold and reperfusion warm ischemic times were 55 years (49–60), 19 (14–21) and 380 (325–430) and 30 min (26–35), respectively. Overall, 236 (59%) and 130 (32%) livers were turned down due to absolute and relative contraindications to donate, respectively. One‐year recipient and graft survivals were 82% and 70%, respectively (median follow‐up 24 months). The applicability of type 2 DCD liver transplant was <10%; however, with better preservation technology and expanded transplant criteria, we may be able to improve this figure significantly.
Xenopus Nkx6.3 Is a Neural Plate Border Specifier Required for Neural Crest Development

In vertebrates, the neural plate border (NPB) is established by a group of transcription factors including Dlx3, Msx1 and Zic1. The crosstalk between these NPB specifiers governs the separation of the NPB region into placode and neural crest (NC) territories and also their further differentiation. Understanding the mechanisms of NPB formation and NC development is critical for our knowledge of related human diseases. Here we identified Nkx6.3, a transcription factor of the Nkx family, as a new NPB specifier required for neural crest development in Xenopus embryos. XNkx6.3 is expressed in the ectoderm of the neural plate border region at neurula stages, covering the epidermis, placode and neural crest territories, but not the neural plate. Inhibition of Nkx6.3 by dominant negative construct or specific morpholino leads to neural crest defects, while overexpression of Nkx6.3 induces ectopic neural crest in the anterior neural fold. In animal caps, Nkx6.3 alone is able to initiate the whole neural crest regulatory network and induces neural crest fate robustly. We showed that overexpression of Nkx6.3 affects multiple signaling pathways, creating a high-Wnt, low-BMP environment required for neural crest development. Gain- and loss-of-function of Nkx6.3 have compound effects on the expression of known NPB genes, which is largely opposite to that of Dlx3. Overexpression of Dlx3 blocks the NC inducing activity of Nkx6.3. The crosstalk between Nkx6.3, Dlx3 and Msx1 is likely crucial for proper NPB formation and neural crest development in Xenopus.
Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells

Liver progenitor cells (LPCs) are activated in chronic liver damage and may contribute to liver fibrosis. Our previous investigation reported that LPCs produced connective tissue growth factor (CTGF/CCN2), an inducer of liver fibrosis, yet the regulatory mechanism of the production of CTGF/CCN2 in LPCs remains elusive. In this study, we report that Activin A is an inducer of CTGF/CCN2 in LPCs. Here we show that expression of both Activin A and CTGF/CCN2 were upregulated in the cirrhotic liver, and the expression of Activin A positively correlates with that of CTGF/CCN2 in liver tissues. We go on to show that Activin A induced de novo synthesis of CTGF/CCN2 in LPC cell lines LE/6 and WB-F344. Furthermore, Activin A contributed to autonomous production of CTGF/CCN2 in liver progenitor cells (LPCs) via activation of the Smad signaling pathway. Smad2, 3 and 4 were all required for this induction. Collectively, these results provide evidence for the fibrotic role of LPCs in the liver and suggest that the Activin A-Smad-CTGF/CCN2 signaling in LPCs may be a therapeutic target of liver fibrosis.
Localization of Members of the γ-Glutamyl Transpeptidase Family Identifies Sites of Glutathione and Glutathione S-Conjugate Hydrolysis1[W][OA]

γ-Glutamyl transpeptidases (GGTs) are essential for hydrolysis of the tripeptide glutathione (γ-glutamate-cysteine-glycine) and glutathione S-conjugates since they are the only enzymes known to cleave the amide bond linking the γ-carboxylate of glutamate to cysteine. In Arabidopsis thaliana, four GGT genes have been identified based on homology with animal GGTs. They are designated GGT1 (At4g39640), GGT2 (At4g39650), GGT3 (At1g69820), and GGT4 (At4g29210). By analyzing the expression of each GGT in plants containing GGT:β-glucuronidase fusions, the temporal and spatial pattern of degradation of glutathione and its metabolites was established, revealing appreciable overlap among GGTs. GGT2 exhibited narrow temporal and spatial expression primarily in immature trichomes, developing seeds, and pollen. GGT1 and GGT3 were coexpressed in most organs/tissues. Their expression was highest at sites of rapid growth including the rosette apex, floral stem apex, and seeds and might pinpoint locations where glutathione is delivered to sink tissues to supplement high demand for cysteine. In mature tissues, they were expressed only in vascular tissue. Knockout mutants of GGT2 and GGT4 showed no phenotype. The rosettes of GGT1 knockouts showed premature senescence after flowering. Knockouts of GGT3 showed reduced number of siliques and reduced seed yield. Knockouts were used to localize and assign catalytic activity to each GGT. In the standard GGT assay with γ-glutamyl p-nitroanilide as substrate, GGT1 accounted for 80% to 99% of the activity in all tissues except seeds where GGT2 was 50% of the activity. Protoplasting experiments indicated that both GGT1 and GGT2 are localized extracellularly but have different physical or chemical associations.
Radio-Frequency Association of Efimov Trimers

Few-Body Problem Seemingly simple, quantum mechanical few-body systems are notoriously difficult to describe. Efimov trimers, three-body bound states with interactions tuned to be in close vicinity of the formation of two-body bound states, are the most tractable of these systems, with relevance, for example, in nuclear physics. Observed recently in ultracold atomic gases through their signatures in the rate of inelastic three-body collisions, Efimov trimers are predicted to appear at interaction strengths whose ratios are universally specified. By measuring binding energy as a function of interaction strength, Lompe et al. (p. 940) directly observed the association of three distinguishable atoms into a bound state. This technique may enable more precise studies of the trimer state, potentially revealing the nature of nonuniversal corrections suggested by prior experiments. A bound state of three fermionic atoms in different quantum states is formed directly by laser association. The quantum mechanical three-body problem is one of the fundamental challenges of few-body physics. When the two-body interactions become resonant, an infinite series of universal three-body bound states is predicted to occur, whose properties are determined by the strength of the two-body interactions. We used radio-frequency fields to associate Efimov trimers consisting of three distinguishable fermions. The measurements of their binding energy are consistent with theoretical predictions that include nonuniversal corrections.