Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of Crustacean Chitin as a Co-diluent in Direct Compression of Tablets

A “simplex-centroid mixture design” was used to study the direct-compression properties of binary and ternary mixtures of chitin and two cellulosic direct-compression diluents. Native milled and fractioned (125–250 μm) crustacean chitin of lobster origin was blended with microcrystalline cellulose, MCC (Avicel® PH 102) and spray-dried lactose–cellulose, SDLC Cellactose® (composed of a spray-dried mixture of alpha-lactose monohydrate 75% and cellulose powder 25%). An instrumented single-punch tablet machine was used for tablet compactions. The flowability of the powder mixtures composed of a high percentage of chitin and SDLC was clearly improved. The fractioned pure chitin powder was easily compressed into tablets by using a magnesium stearate level of 0.1% (w/w) but, as the die lubricant level was 0.5% (w/w), the tablet strength collapsed dramatically. The tablets compressed from the binary mixtures of MCC and SDLC exhibited elevated mechanical strengths (>100 N) independent of the die lubricant level applied. In conclusion, fractioned chitin of crustacean origin can be used as an abundant direct-compression co-diluent with the established cellulosic excipients to modify the mechanical strength and, consequently, the disintegration of the tablets. Chitin of crustacean origin, however, is a lubrication-sensitive material, and this should be taken into account in formulating direct-compression tablets of it.
Collectivism, Political Control, and Gating in Chinese Cities

This paper provides a conceptual framework emphasizing the role of culture and the state in understanding gating in different countries, and applies it to examine the long-existing and widespread neighborhood enclosure and gating in Chinese cities. It is argued that the collectivist culture deeply embedded in Chinese society and tight political control actively pursued by the government contribute to the widespread character of gating in China, whereas dominant Western-based theories such as the discourse of fear and private provision of public services are less applicable, even though they are becoming increasingly important in the new gated private housing. Gating and neighborhood enclosure in China help to define a sense of collectivism and foster social solidarity. Thus gating per se does not necessarily lead to residential segregation, although it begins to reinforce segregation in the reform era. Gating also facilitates political control through neighborhood-level governments whose jurisdiction often corresponds to enclosed neighborhoods but forms change between different political-historical periods. Thus, while the physical form of gating is similar between China and the United States, the underlying sociopolitical constructs and implications are quite different.
A Model for Measuring Software Understandability

When programmers try to reuse a software system developed by other programmers, the difficulty of understanding the system limits reuses [1]. It is not easy to measure software understandability because understanding is an internal process of humans. This paper proposes "integral of understandability" as a model for measuring software understandability which can extract first the best value of software understandability from factors with higher weight. In other words, we gave an integrated aspect of measuring software understandability through the literature on the subject.
The Precut – When, Where and How? A Review

Gaining access to the biliary or pancreatic duct is the most important step for a successful therapeutic biliary pancreatic endoscopy. The overall success rate of cannulation ranges from 90 to 95% evenwhen performed by experts [1]. In about 5 to 10% of cases, the common bile duct remains inaccessible necessitating “precut” [2–5]. Precut sphincterotomy is the Achilles’ heel of many an endoscopist and the ultimate tool in the biliary endoscopist’s armamentarium for gaining access across the papilla to facilitate biliary endotherapy. It is often considered to be ‘dangerous’, ‘complicated’ and to be reserved for the ‘experts’ [6]. Like any other interventional procedure, precut is associated with its attendant risks and morbidity, the most important complication being endoscopic retrograde cholangiopancreatography (ERCP) induced acute pancreatitis [7–14]. This follows trauma and edema of the papilla due to multiple unsuccessful attempts and inadvertent pancreatic duct cannulations and precutting in such circumstances results in higher morbidity, especially when performed on undilated bile ducts [15,16]. Hence, it is all the more important to teach and train the inexperienced about when, where, and how to do precut sphincterotomy. We have reviewed precutting with regard to its basis, technical aspects, and the available relevant literature.
New Perspectives in the Treatment of Colorectal Metastases

Background: In recent years, the management of metastatic colorectal cancer has become more aggressive and more multidisciplinary. New treatment options have been proposed in addition to the standard approach of resection of liver metastases and chemotherapy. Summary: Selected patients with synchronous limited peritoneal and liver disease (peritoneal cancer index <12 and <3 liver metastases) can be scheduled for aggressive treatment, including cytoreductive surgery, hyperthermic intraperitoneal chemotherapy, and liver resection. This approach has achieved survival benefits, even if the treatment is unlikely to be curative in most patients. Moreover, liver transplantation has been recently reconsidered for liver-only metastases, resulting in the defacto reinstatement of the chance of surgery for some unresectable patients. Even though indications for liver transplantation remain to be standardized, preliminary studies have reported extremely promising outcomes. Radio-embolization has proven to be an effective additional tool for the treatment of unresectable tumors, and its potential role in association with chemotherapy for resectable disease is currently being investigated. Stereotactic body radiation therapy is a safe, non-invasive, and effective therapeutic option for patients with inoperable oligometastatic disease. Thanks to recent technical progress, high radiation doses can now be delivered in fewer fractions with excellent local disease control and a low risk of radiation-induced liver injury. Finally, radiofrequency ablation (RFA) for colorectal metastases has become more effective, with results approaching those of surgical series. New interstitial treatments, such as microwave ablation and irreversible electroporation, could overcome some of the limitations of RFA, thereby further expanding indications and optimizing outcomes. Key Messages: Currently, a multidisciplinary approach to patients with colorectal liver metastases is mandatory. Aggressive surgical treatments should be integrated with all the available non-surgical options to maximize disease control and patient survival.
Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore*

The molecular basis of ligand binding and activation of family B G protein-coupled receptors is not yet clear due to the lack of insight into the structure of intact receptors. Although NMR and crystal structures of amino-terminal domains of several family members support consistency in general structural motifs that include a peptide-binding cleft, there are variations in the details of docking of the carboxyl terminus of peptide ligands within this cleft, and there is no information about siting of the amino terminus of these peptides. There are also no empirical data to orient the receptor amino terminus relative to the core helical bundle domain. Here, we prepared a series of five new probes, incorporating photolabile moieties into positions 2, 15, 20, 24, and 25 of full agonist secretin analogues. Each bound specifically to the receptor and covalently labeled single distinct receptor residues. Peptide mapping of labeled wild-type and mutant receptors identified that the position 15, 20, and 25 probes labeled residues within the distal amino terminus of the receptor, whereas the position 24 probe labeled the amino terminus adjacent to TM1. Of note, the position 2 probe labeled a residue within the first extracellular loop of the receptor, a region not previously labeled, providing an important new constraint for docking the amino-terminal region of secretin to its receptor core. These additional experimentally derived constraints help to refine our understanding of the structure of the secretin-intact receptor complex and provide new insights into understanding the molecular mechanism for activation of family B G protein-coupled receptors.
Electrostatic Solid Lubricant Coatings: Optimization of Process Parameters and Performance in Tribological Tests

The scope of this study is to optimize the electrostatic solid lubricant coating deposition process parameters such as electric potential, solid lubricant feed pressure and distance between the nozzle tip to metal substrate on its average surface roughness of the coatings. Statistical design approach was used to plan and confirm the experimental investigation. In addition, tribological performance of coatings is assessed through pin-on-disc tests under dry sliding conditions. Results demonstrate that the electric potential has the most significant effect on the roughness of coatings. Electrostatic solid lubricant coatings works quite satisfactorily in dry sliding conditions and can endow in making sliding process more environmental friendly.
Metal-enriched plasma in protogalactic halos. A survey of N V absorption in high-z damped and sub-da

We continue our recent work of characterizing the plasma content of high-redshift damped and sub-damped Lyman-α systems (DLAs/sub-DLAs), which represent multi-phase gaseous (proto)galactic disks and halos seen toward a background source. We survey N v absorption in a sample of 91 DLAs and 18 sub-DLAs in the redshift range 1.67 −2.3. The N v and C iv component b-value distributions in DLAs are statistically similar, but the median b(N v )o f 18 km s −1 is narrower than the median b(O vi )o f≈25 km s −1 . S ome≈20% of the N v components have b 14 or log N(O vi) > 14.2), which present challenges to either galactic inflow or outflow models.
Designer drugs: a medicinal chemistry perspective

There are numerous medicinal chemistry reports in the literature describing the pharmacological properties of thousands of narcotics, stimulants, hallucinogens, sedative‐hypnotic drugs, cannabinoids, and other psychoactive substances as well as synthetic methods for their preparations. This information, while essential for the advancement of science, has been used by clandestine chemists to manufacture and market an endless variety of analogs of so‐called designer drugs. In this review, we describe how clandestine chemists used the principles of medicinal chemistry to design molecules, referred to as designer drugs, that elicit the effects of opioids, amphetamine and analogs, cannabinoids, and phencyclidine analogs while circumventing the law.
Stochastic Block Model and Community Detection in Sparse Graphs: A spectral algorithm with optimal rate of recovery

In this paper, we present and analyze a simple and robust spectral algorithm for the stochastic block model with $k$ blocks, for any $k$ fixed. Our algorithm works with graphs having constant edge density, under an optimal condition on the gap between the density inside a block and the density between the blocks. As a co-product, we settle an open question posed by Abbe et. al. concerning censor block models.
The efficacy of a multifactorial memory training in older adults living in residential care settings

ABSTRACT Background: Several studies have shown an increase in memory performance after teaching mnemonic techniques to older participants. However, transfer effects to non-trained tasks are generally either very small, or not found. Methods: The present study investigates the efficacy of a multifactorial memory training program for older adults living in a residential care center. The program combines teaching of memory strategies with activities based on metacognitive (metamemory) and motivational aspects. Specific training-related gains in the Immediate list recall task (criterion task), as well as transfer effects on measures of short-term memory, long-term memory, working memory, motivational (need for cognition), and metacognitive aspects (subjective measure of one's memory) were examined. Maintenance of training benefits was assessed after seven months. Fifty-one older adults living in a residential care center, with no cognitive impairments, participated in the study. Participants were randomly assigned to two programs: the experimental group attended the training program, while the active control group was involved in a program in which different psychological issues were discussed. Results: A benefit in the criterion task and substantial general transfer effects were found for the trained group, but not for the active control, and they were maintained at the seven months follow-up. Conclusion: Our results suggest that training procedures, which combine teaching of strategies with metacognitive–motivational aspects, can improve cognitive functioning and attitude toward cognitive activities in older adults.
Predicted life of P91 steel for cyclic high temperature service

Abstract The P91 steel is widely used in high temperature components of power plants, and it is a candidate material for Gen-IV reactors. The P91 steel has relatively attractive mechanical and physical properties combined with resistance to stress corrosion cracking in water–steam environments. This study aimed to explore the combined cyclic, creep and relaxation behaviour of P91 material. Uniaxial specimens were subjected to cyclic loadings with periodic forward creep or relaxation at peak stress. The results indicate that prior creep or intermediate relaxation periods up to 72 h will influence the subsequent cyclic softening of P91, but do not significantly reduce the cyclic life. In contrast, prior cycling has a detrimental effect on the subsequent creep life. A simplified creep-fatigue model is shown to predict life better than usual code-based approaches. Improved verification of all models would benefit from the availability of more extensive long-term data on P91 steel.
Caries lesions and dental restorations as predisposing factors in the progression of periodontal diseases in adolescents. A 3-year longitudinal study.

The present study used a novel approach to assess the relationship between untreated caries lesions and defective and non-defective dental restorations and the incidence of gingival inflammation and the progression of chronic inflammatory periodontal diseases at the approximal surfaces of posterior teeth and at the adjacent surface of the neighboring tooth in adolescents over a period of 3 years. Two hundred-twenty-seven (227) 13-year-old schoolchildren were examined clinically and radiographically at baseline and annually at three subsequent occasions. At each site the alveolar bone height and presence of gingival bleeding were assessed. Incipient caries lesions, manifest caries, and defective and non-defective restorations were identified at the same site and also at the adjacent approximal tooth surface at all examinations, both clinically and radiographically. The data were analyzed by the multi-level logistic regression and variance components analyses. On average, 32, 8.5, 7, and 10% of the sites, respectively, were diagnosed as having incipient caries, manifest caries, and defective and non-defective restorations. There was a significant association between the presence of untreated manifest caries lesions, non-defective and defective dental restorations, and the progression of periodontal support loss. Also there was an association between presence of defective restorations and manifest caries and the incidence of gingival inflammation. Consistently, factors detected at the involved site and at the adjacent site had significant effects. The present study indicates that untreated cavities and dental restorations are predisposing factors with a significant negative effect on periodontal health in adolescents. (ABSTRACT TRUNCATED AT 250 WORDS)
A survey of algebraic properties used in cryptographic protocols

Cryptographic protocols are successfully analyzed using formal methods. However, formal approaches usually consider the encryption schemes as black boxes and assume that an adversary cannot learn anything from an encrypted message except if he has the key. Such an assumption is too strong in general since some attacks exploit in a clever way the interaction between protocol rules and properties of cryptographic operators. Moreover, the executability of some protocols relies explicitly on some algebraic properties of cryptographic primitives such as commutative encryption. We give a list of some relevant algebraic properties of cryptographic operators, and for each of them, we provide examples of protocols or attacks using these properties. We also give an overview of the existing methods in formal approaches for analyzing cryptographic protocols.
How should we define fitness in structured metapopulation models? Including an application to the calculation of evolutionarily stable dispersal strategies

We define a fitness concept applicable to structured metapopulations consisting of infinitely many equally coupled patches. In addition, we introduce a more easily calculated quantity Rm that relates to fitness in the same manner as R0 relates to fitness in ordinary population dynamics: the Rm of a mutant is only defined when the resident population dynamics converges to a point equilibrium and Rm is larger (smaller) than 1 if and only if mutant fitness is positive (negative). Rm corresponds to the average number of newborn dispersers resulting from the (on average less than one) local colony founded by a newborn disperser. Efficient algorithms for calculating its numerical value are provided. As an example of the usefulness of these concepts we calculate the evolutionarily stable conditional dispersal strategy for individuals that can account for the local population density in their dispersal decisions. Below a threshold density ã, at which staying and leaving are equality profitable, everybody should stay and above ã everybody should leave, where profitability is measured as the mean number of dispersers produced through lines of descent consisting of only non–dispersers.
Temperature affects respiration rate of Oithona similis

Oithona spp. is considered the most abundant and ubiquitous copepod genus in the marine environment, often outnumbering calanoid copepods throughout the year. Previous studies have argued that one of the reasons for such success is that the respiration rate of Oithona spp. is insensitive to temperature changes and lower than in calanoids. However, comprehensive data on the thermal biology of this important copepod genus is lacking. In this study, the respiration rate of adult female O. similis from the English Channel, was measured over the temperature range 4 to 25°C. The respiration rate of O. similis changed exponentially with temperature (ln O2-rate = -3.59 + 0.114 T, df = 35, r 2 = 0.85, p < 0.001, Q10 = 3.1) similar to that of other poikilotherms. Over the temperature range examined, O. similis basic metabolic cost varied from a minimum of ~1.4% body-C d -1 at 4°C to a maximum of 23% body-C d -1 at 25°C, corresponding to an energy demand of ~3% and 32% body-C d -1 respectively. The respiration rate of O. similis, from the present study, is ~8 times lower than that of a calanoid copepod of equivalent body weight estimated from published empirical metabolism-temperature data. We suggest that these differences in metabolic rates may account for the year-round persistence and higher abundances of Oithona spp. over calanoid copepods, particu- larly in oceanic and oligotrophic environments where food resources may be limiting for calanoid copepods.
Adaptation to Hydrogen Sulfide of Oxygenic and Anoxygenic Photosynthesis among Cyanobacteria

Four different types of adaptation to sulfide among cyanobacteria are described based on the differential toxicity to sulfide of photosystems I and II and the capacity for the induction of anoxygenic photosynthesis. Most cyanobacteria are highly sensitive to sulfide toxicity, and brief exposures to low concentrations cause complete and irreversible cessation of CO2 photoassimilation. Resistance of photosystem II to sulfide toxicity, allowing for oxygenic photosynthesis under sulfide, is found in cyanobacteria exposed to low H2S concentrations in various hot springs. When H2S levels exceed 200 μM another type of adaptation involving partial induction of anoxygenic photosynthesis, operating in concert with partially inhibited oxygenic photosynthesis, is found in cyanobacterial strains isolated from both hot springs and hypersaline cyanobacterial mats. The fourth type of adaptation to sulfide is found at H2S concentrations higher than 1 mM and involves a complete replacement of oxygenic photosynthesis by an effective sulfide-dependent, photosystem II-independent anoxygenic photosynthesis. The ecophysiology of the various sulfide-adapted cyanobacteria may point to their uniqueness within the division of cyanobacteria.
The Difficulty of Training Deep Architectures and the Effect of Unsupervised Pre-Training

Whereas theoretical work suggests that deep architectures might be more e cient at representing highly-varying functions, training deep architectures was unsuccessful until the recent advent of algorithms based on unsupervised pretraining. Even though these new algorithms have enabled training deep models, many questions remain as to the nature of this di cult learning problem. Answering these questions is important if learning in deep architectures is to be further improved. We attempt to shed some light on these questions through extensive simulations. The experiments confirm and clarify the advantage of unsupervised pre-training. They demonstrate the robustness of the training procedure with respect to the random initialization, the positive e ect of pre-training in terms of optimization and its role as a regularizer. We empirically show the influence of pre-training with respect to architecture depth, model capacity, and number of training examples.
Microfinance and Economic Development

Microfinance is generally seen as a way to fix credit markets and unleash the productive capacities of poor people who are dependent on self-employment. The microfinance sector has grown quickly since the 1990s, paving the way for other forms of social enterprise and social investment. But recent evidence shows only modest average impacts on customers, generating a backlash against microfinance. This paper reconsiders the claims about microfinance, highlighting the diversity in evidence on impacts and the important (but limited) role of subsidies. The paper concludes by describing an evolution of thinking: from microfinance as narrowly construed entrepreneurial finance toward microfinance as broadly construed household finance. In this vision, microfinance yields benefits by providing liquidity for a wide range of needs rather than solely by boosting business income.