Miracle-dz/UniFAR-FTUs huggingface dataset:
Kaleidoscope: Real-time content delivery in software defined infrastructures

Real-time content delivery services such as live media streaming, news casting and real-time event subscription/publication systems have become popular in recent years. Unlike traditional content delivery applications, real-time content delivery requires live content to be processed and delivered to end users in a timely and efficient manner. Furthermore, as both content producers and consumers may change over-time, it is a challenge to provision resources for these applications to achieve high service quality while minimizing total operational costs. Fortunately, the recent development of Cloud computing and Software Defined Networking (SDN) enables efficient implementation of real-time content delivery systems. Recently, the concept of Software Defined Infrastructure aims at combining Cloud computing and SDN to provide an unified framework for application deployment and management. In this paper, we present Kaleidoscope, an architecture for real-time content delivery in Software Defined Infrastructures. Kaleidoscope leverages network virtualization, SDN-based broadcasting and dynamic cloud resource provisioning to achieve high resource efficiency and service performance. Specifically, we present a resource management scheme that controls Cloud resource allocation and network configuration at run-time in accordance with service demand. Experiments show that Kaleidoscope is able to achieve lower resource cost while providing high service quality.
WISP1 Is a Novel Adipokine Linked to Inflammation in Obesity

WISP1 (Wnt1-inducible signaling pathway protein-1, also known as CCN4) is a member of the secreted extracellular matrix–associated proteins of the CCN family and a target gene of the Wingless-type (WNT) signaling pathway. Growing evidence links the WNT signaling pathway to the regulation of adipogenesis and low-grade inflammation in obesity. We aimed to validate WISP1 as a novel adipokine. Human adipocyte differentiation was associated with increased WISP1 expression and secretion. Stimulation of human macrophages with WISP1 led to a proinflammatory response. Circulating WISP1 and WISP1 subcutaneous adipose tissue expression were regulated by weight changes in humans and mice. WISP1 expression in visceral and subcutaneous fat tissue was associated with markers of insulin resistance and inflammation in glucose-tolerant subjects. In patients with nonalcoholic fatty liver disease, we found no correlation among disease activity score, liver fat content, and WISP1 expression. Insulin regulated WISP1 expression in adipocytes in vitro but had no acute effect on WISP1 gene expression in subcutaneous fat tissue in overweight subjects who had undergone hyperinsulinemic clamp experiments. The data suggest that WISP1 may play a role in linking obesity to inflammation and insulin resistance and could be a novel therapeutic target for obesity.
Combination of Antioxidants from Different Sources Could offer Synergistic Benefits: A Case Study of Tea and Ginger Blend

Tea and ginger are plants with high antioxidant potential. Combinations of antioxidants from different sources could also produce synergistic antioxidant effects. This study investigated the influence of solvent on antioxidant content of tea, ginger, and tea + ginger blends. Under the investigated extraction conditions, water was the most effective extraction solvent to maximise peroxide scavenging and iron chelating activity of tea, ginger, and their blends. Aqueous ethanol was the most effective solvent to maximise ABTS radical scavenging activity and ethanol was the best solvent to maximise DPPH radical scavenging activity. A good multivariate regression model that explains the relationship between the total flavonoid content of the extracts and their antioxidant activities was obtained (R2 and Q2 of 0.93 and 0.83, respectively). Extracts of tea-ginger blends exhibited synergistic effects in their ABTS and DPPH radical scavenging activity.
Polarization rotation and the third Stokes parameter: the effects of spacecraft attitude and Faraday rotation

The third Stokes parameter of ocean surface brightness temperatures measured by the WindSat instrument is sensitive to the rotation angle between the polarization vectors at the ocean surface and the instrument. This rotation angle depends on the spacecraft attitude (roll, pitch, yaw) as well as the Faraday rotation of the electromagnetic radiation passing through the Earth's ionosphere. Analyzing the WindSat antenna temperatures, we find biases in the third Stokes parameter as function of the along-scan position of up to 1.5 K in all feedhorns. This points to a misspecification of the reported spacecraft attitude. A single attitude correction of -0.16/spl deg/ roll and 0.18/spl deg/ pitch for the whole instrument eliminates all the biases. We also study the effect of Faraday rotation at 10.7 GHz on the accuracy of the third Stokes parameter and the sea surface wind direction retrieval and demonstrate how this error can be corrected using values from the International Reference Ionosphere for the total electron content when computing Faraday rotation.
[Prevalence of risk health behavior among adolescents: results from the 2009 National Adolescent School-based Health Survey (PeNSE)].

UNLABELLED Adolescence is typically a developmental phase characterized by change and experimentation and therefore varying exposure to health hazards. We aimed at estimating the prevalence of protective and risk health behaviors of adolescents interviewed in the 2009 National Adolescent School-based Health Survey (PeNSE). PeNSE, a partnership between the Instituto Brasileiro de Geografia e Estatística (IBGE) and the Ministry of Health, using a PDA-based self-administered questionnaire collected information on 60,973 students enrolled at 1,453 public and private schools in the 27 state capitals and the Federal District. RESULTS Among the food items most often consumed ( > or = 5 days per week), were beans (62.6%) and fruit (31.5%), but also sweets (58.3%) and soft drinks (37%), 43.1% of the students were sufficiently physically active but 79.5% spent >2 hours per day in front of the TV. As for drug use, 6.3% reported being current tobacco smokers, 27% drank alcoholic beverages regularly and 8.7% had used illicit drugs at least once. These results should guide stakeholders and policy makers in the development and implementation of programs and recommendations aimed at curtailing unhealthy exposures of adolescents in Brazil.
HPV16 E6 upregulates Aurora A expression

Overexpression of Aurora A kinase occurs in certain types of cancer, and therefore results in chromosome instability and phosphorylation-mediated ubiquitylation and degradation of p53 for tumorigenesis. The high-risk subtype human papillomavirus (HPV)16 early oncoprotein E6 is a major contributor inducing host cell immortalization and transformation through interaction with a number of cellular factors. In the present study, co-immunoprecipitation, glutathione S-transferase pull-down and immunostaining were used to show that HPV16 E6 and Aurora A bind to each other in vivo and in vitro. Western blotting and reverse transcription-polymerase chain reaction were used to reveal that HPV16 E6 inhibited cell apoptosis by stabilizing Aurora A expression. The present study may report a new mechanism for the involvement of HPV16 E6 in carcinogenesis, as HPV16 E6 elevates Aurora A expression and the latter may be a common target for oncogenic viruses that result in cell carcinogenesis.
The Relationship between Systematic Risk Proportion and the Slope of the Implied Volatility Curve

In this empirical study, we examine one of the fundamental assumptions of the Black-Scholes Option Pricing Theory; that the proportion of systematic risk of total risk has no effect on intrinsic option prices. This hypothesis was first proposed by Jin-Chuan Duan and Jason Wei (2006) and we will use a similar methodology in testing the hypothesis that the slope of implied volatility curve is related to the proportion of systematic risk of the underlying asset. We will use daily option quotes on the components of the S&P100 index in order to explore the relationship between the systematic risk proportion and the slope of the implied volatility curve: specifically, we hope to establish that it has a direct impact in that the higher the systematic risk proportion, the steeper the slope of the implied volatility curve. The author would like to thank the Stern School of Business at New York University for its support of this research effort. In particular, I would like to thank M. Subrahmanyam, coordinator of the Honors Program, R. Engle, my thesis advisor, A. Mistry, W. Boudry and S. Joens of the Finance Department at the NYU Stern School of Business for their invaluable contributions. The authors email address is kwee12@gmail.com. Any remaining errors are the sole responsibility of the author.
Assessment of Global Cloud Datasets from Satellites: Project and Database Initiated by the GEWEX Radiation Panel

Clouds cover about 70% of Earth's surface and play a dominant role in the energy and water cycle of our planet. Only satellite observations provide a continuous survey of the state of the atmosphere over the entire globe and across the wide range of spatial and temporal scales that compose weather and climate variability. Satellite cloud data records now exceed more than 25 years; however, climate data records must be compiled from different satellite datasets and can exhibit systematic biases. Questions therefore arise as to the accuracy and limitations of the various sensors and retrieval methods. The Global Energy and Water Cycle Experiment (GEWEX) Cloud Assessment, initiated in 2005 by the GEWEX Radiation Panel (GEWEX Data and Assessment Panel since 2011), provides the first coordinated intercomparison of publicly available, standard global cloud products (gridded monthly statistics) retrieved from measurements of multispectral imagers (some with multiangle view and polarization capabilities), IR soun.
Evaluation and Comparison of Respiratory Symptoms and Lung Capacities in Tile and Ceramic Factory Workers of Yazd

Evaluation and Comparison of Respiratory Symptoms and Lung Capacities in Tile and Ceramic Factory Workers of Yazd Tile workers are exposed to dust particles and are susceptible to multiple pulmonary complications. Problems like asthma, chronic obstructive pulmonary symptoms, and silicosis are more common among them. As there are many tile factories in Yazd, we decided to evaluate the respiratory symptoms and lung capacities in these workers and compare them with controls. This study included 176 tile and ceramic factory workers occupationally exposed to dust and 115 unexposed workers as controls. We recorded the respiratory symptoms using the British Medical Research Council questionnaire and measured lung capacities of the two groups. All study subjects were male, and the two groups were comparable in age and smoking. The exposed group had frequent respiratory symptoms and a significant relationship between them and duration of employment. In addition, lung capacities in ceramic workers with symptoms were lower than in workers without the symptoms. Even though the respiratory symptoms were more frequent in the exposed group than in controls, lung capacities of the two groups were similar. Ocjena i usporedba respiratornih simptoma i kapaciteta pluća u radnika tvornice keramičkih pločica iz Yazda u Iranu Radnici u proizvodnji keramičkih pločica izloženi su česticama prašine te su skloni višestrukim plućnim komplikacijama. U njih je veća učestalost tegoba poput astme i simptoma kronične opstruktivne bolesti pluća te silikoze. Budući da u Yazdu ima mnogo tvornica keramike, odlučili smo upravo u tome gradu ocijeniti respiratorne simptome i izmjeriti kapacitet pluća njihovih radnika i usporediti ih s kontrolnom skupinom. Ispitivanje je stoga obuhvatilo 176 radnika u proizvodnji keramičkih pločica izloženih prašini te 115 neizloženih radnika koji su činili kontrolnu skupinu. Respiratorni su se simptomi ispitali rabeći upitnik Britanskoga savjeta za medicinska istraživanja (British Medical Research Council), a u obje je skupine izmjeren kapacitet pluća. Svi su ispitanici bili muškarci, a skupine su se podudarale po dobi i pušenju. Respiratorni simptomi bili su česti u izloženoj skupini te je u njoj uočena značajna povezanost izmedu respiratornih simptoma i radnoga staža u tvornici. Usto su izloženi radnici s respiratornim simptomima iskazali slabije kapacitete pluća od radnika bez simptoma. Ovi su respiratorni simptomi bili češći u izloženoj skupini negoli u kontrolnoj, ali se njihovi kapaciteti pluća nisu bitno razlikovali.
Clinical Outcome of Total Knee Arthroplasty Performed Using Patient-Specific Cutting Guides

Background Patient-specific instruments have recently gained attention for ensuring the accuracy of osteotomy and correct alignment in total knee arthroplasty (TKA). We aimed to report our experience with TKA performed by using CT-based 3D model of cutting guides in our clinic. Material/Methods A total of 36 patients (mean age, 67.58±8.46 years; 24 females, 12 males) who underwent TKA with 3D patient-specific cutting guides in our clinic were included in the study. Differences between preoperatively planned bone resections and actual bone resections were calculated. Femoral and tibial component angles were measured on radiographs of the knee. The change in knee pain was evaluated by patients on a 10-point visual analog scale (VAS). Patients were followed up for 6 months postoperatively. Results The actual bone resection was 0.5–1.5 mm higher than the planned resection for all sides, being statistically significant for posterior lateral and distal medial sides (1.1±1.3 mm and 1.5±0.9 mm, respectively; p<0.05). On postoperative radiographs, coronal tibial component angle was 88.8°±0.9° and coronal femoral component angle was 95.2°±1.6°, showing good postoperative alignment. The VAS pain score of patients significantly decreased from preoperative 3.9±0.8 to 1.1±0.9 at 6 months after the operation. One patient developed superficial tissue infection on postoperative follow-up, which was effectively treated. No other pathology was detected in the postoperative period. Conclusions Patient-specific cutting guides can provide intraoperative guidance for better placement of the implant in TKA and increase the accuracy of osteotomy and postoperative alignment.
Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis

We have developed a cell-free system that induces the morphological transformations characteristic of apoptosis in isolated nuclei. The system uses extracts prepared from mitotic chicken hepatoma cells following a sequential S phase/M phase synchronization. When nuclei are added to these extracts, the chromatin becomes highly condensed into spherical domains that ultimately extrude through the nuclear envelope, forming apoptotic bodies. The process is highly synchronous, and the structural changes are completed within 60 min. Coincident with these morphological changes, the nuclear DNA is cleaved into a nucleosomal ladder. Both processes are inhibited by Zn2+, an inhibitor of apoptosis in intact cells. Nuclear lamina disassembly accompanies these structural changes in added nuclei, and we show that lamina disassembly is a characteristic feature of apoptosis in intact cells of mouse, human and chicken. This system may provide a powerful means of dissecting the biochemical mechanisms underlying the final stages of apoptosis.
Is Anticonvulsant Treatment of Mania a Class Effect? Data from Randomized Clinical Trials

Our aim was to evaluate the efficacy and tolerability of anticonvulsant agents for the treatment of acute bipolar mania and ascertain if their effects on mania are a “class” effect. We conducted a systematic review of randomized controlled trials (RCTs) with placebo or active comparator, in acute bipolar mania in order to summarize available data on anticonvulsant treatment of mania/mixed episodes. We searched (PubMed/MEDLINE) with the combination of the words “acute mania” and “clinical trials” with each one of the following words: “anticonvulsants/antiepileptics,”“valproic/valproate/divalproex,”“carbamazepine,”“oxcarbazepine,”“lamotrigine,”“gabapentin,”“topiramate,”“phenytoin,”“zonisamide,”“retigabine,”“pregabalin,”“tiagabine,”“levetiracetam,”“licarbazepine,”“felbamate,” and “vigabatrin. ” Original articles were found until November 1, 2008. Data from 35 randomized clinical trials suggested that not all anticonvulsants are efficacious for the treatment of acute mania. Valproate showed greater efficacy in reducing manic symptoms, with response rates around 50% compared to a placebo effect of 20–30%. It appears to have a more robust antimanic effect than lithium in rapid cycling and mixed episodes. As valproate, the antimanic effects of carbamazepine have been demonstrated. Evidences did not support the efficacy of the gabapentin, topiramate as well as lamotrigine as monotherapy in acute mania and mixed episodes. Oxcarbazepine data are inconclusive and data regarding other anticonvulsants are not available. Anticonvulsants are not a class when treating mania. While valproate and carbamazepine are significantly more effective than placebo, gabapentin, topiramate, and lamotrigine are not. However, some anticonvulsants may be efficacious in treating some psychiatric comorbidities that are commonly associated to bipolar illness.
Managerial Ownership Dynamics and Firm Value

From 1988 to 2003, the average change in managerial ownership is significantly negative every year for American firms. The probability of large decreases in ownership is strongly increasing in contemporaneous and past stock returns but the probability of large increases in ownership through managerial purchases of shares is not. The relation between changes in Tobin's q and past and contemporaneous changes in ownership depends critically on controlling for past stock returns. When controlling for past stock returns, past large decreases in managerial ownership are unrelated to current changes in Tobin's q but there is some evidence that past large increases in managerial ownership are positively related to current changes in Tobin's q. Because managers sell shares when a firm's stock is performing well, large contemporaneous decreases in managerial ownership are associated with increases in Tobin's q. We argue that our evidence is mostly inconsistent with existing theories and propose a managerial discretion theory of ownership consistent with our evidence.
The “Things Themselves” in Phenomenology

Abstract The following paper explores the foundations of phenomenology, and seeks to provide those new to the discipline with ways of understanding its claims to assist knowers to attend to ‘the things themselves’. Practical applications of this mode of inquiry are linked to adult education practice which is the author’s field of practice but most of the ideas are readily applicable to social events and practices such as nursing, social work, recreation, history and the like.
Cd2 Sets Quantitative Thresholds in T Cell Activation

It has been proposed that CD2, which is highly expressed on T cells, serves to enhance T cell–antigen presenting cell (APC) adhesion and costimulate T cell activation. Here we analyzed the role of CD2 using CD2-deficient mice crossed with transgenic mice expressing a T cell receptor specific for lymphocytic choriomeningitis virus (LCMV)-derived peptide p33. We found that absence of CD2 on T cells shifted the p33-specific dose–response curve in vitro by a factor of 3–10. In comparison, stimulation of T cells in the absence of lymphocyte function–associated antigen (LFA)-1–intercellular adhesion molecule (ICAM)-1 interaction shifted the dose–response curve by a factor of 10, whereas absence of both CD2–CD48 and LFA-1–ICAM-1 interactions shifted the response by a factor of ∼100. This indicates that CD2 and LFA-1 facilitate T cell activation additively. T cell activation at low antigen density was blocked at its very first steps, as T cell APC conjugate formation, TCR triggering, and Ca2+ fluxes were affected by the absence of CD2. In vivo, LCMV-specific, CD2-deficient T cells proliferated normally upon infection with live virus but responded in a reduced fashion upon cross-priming. Thus, CD2 sets quantitative thresholds and fine-tunes T cell activation both in vitro and in vivo.
Comparative Study of Part-Based Handwritten Character Recognition Methods

The purpose of this paper is to introduce three part-based methods for handwritten character recognition and then compare their performances experimentally. All of those methods decompose handwritten characters into "parts". Then some recognition processes are done in a part-wise manner and, finally, the recognition results at all the parts are combined via voting to have the recognition result of the entire character. Since part-based methods do not rely on the global structure of the character, we can expect their robustness against various deformations. Three voting methods have been investigated for the combination: single voting, multiple voting, and class distance. All of them use different strategies for voting. Experimental results on the MNIST database showed the relative superiority of the class distance method and the robustness of the multiple voting method against the reduction of training set.
Signaling Product Quality Information in Supply Chains via Corporate Social Responsibility Choices

This study focuses on how an upstream supplier signals the private information of its product quality with corporate social responsibility (CSR) choices to a downstream retailer and uninformed consumers in the final market. We build a signaling model to: capture the strategic interactions among the supplier, the retailer, and the final consumers in the supply chain; characterize completely the set of all separating perfect Bayesian equilibriums (PBEs); and finally, select a unique equilibrium that satisfies the intuitive criterion for exploring some comparative statics. The equilibrium results show that under some technical conditions: (1) a set of moderate levels of CSR conduct signal the upstream supplier’s high quality in the sense of separating PBEs; (2) the unique separating PBE satisfying the intuitive criterion is the one with the lowest CSR level that separates a high-quality supplier from a low-quality supplier; (3) the lowest CSR level decreases in the proportion of informed consumers and the low-quality supplier’s marginal CSR cost, but is independent of the high-quality supplier’s marginal CSR cost; (4) the profits of the high-quality supplier increase in proportion to the number of informed consumers and the low-quality supplier’s marginal cost CSR, but decrease in proportion to the high-quality supplier’s marginal CSR cost. Managerial insights are also discussed.
Amenorrhoea, Galactorrhoea, and Primary Hypothyroidism with High Circulating Levels of Prolactin

A 22-year-old woman with primary hypothyroidism developed amenorrhoea and galactorrhoea during oral contraceptive therapy. Investigation showed high levels of circulating prolactin which rose in response to insulin-induced hypoglycaemia and were suppressed by an oral glucose load. After treatment with thyroxine normal periods returned, the galactorrhoea improved, and the prolactin levels fell to undetectable levels. The results of the prolactin and human growth hormone assays confirm that it is possible to distinguish between human growth hormone and human prolactin.