Miracle-dz/UniFAR-FTUs huggingface dataset:
The SAURON project – X. The orbital anisotropy of elliptical and lenticular galaxies: revisiting the (V/σ, ɛ) diagram with integral‐field stellar kinematics

We analyse the orbital distribution of elliptical (E) and lenticular (S0) galaxies using SAURON integral-field stellar kinematics within about one effective (half-light) radius. We construct the anisotropy diagram, which relates the ratio of the ordered and random motion in a galaxy (V/sigma) to its observed ellipticity (epsilon), for the 48 E/S0 galaxies from the SAURON survey. For a subsample of 24 galaxies consistent with axisymmetry, we use three-integral axisymmetric Schwarzschild dynamical models to recover the detailed orbital distribution, and we find good agreement with the anisotropy derived from the (V/sigma, epsilon) diagram. In a companion paper (Paper IX), we show that the early-type galaxies can be subdivided into two classes of systems with or without a significant amount of specific stellar angular momentum. Here, we show that the two classes have different distributions on the (V/sigma, epsilon) diagram. The slow rotators are more common among the most massive systems and are generally classified as E from photometry alone. Those in our sample tend to be fairly round(epsilon less than or similar to 0.3), but can have significant kinematical misalignments, indicating that as a class they are moderately triaxial, and span a range of anisotropies (delta less than or similar to 0.3). The fast rotators are generally fainter and are classified as either E or S0. They can appear quite flattened (epsilon less than or similar to 0.7), do not show significant kinematical misalignments (unless barred or interacting), indicating they are nearly axisymmetric and span an even larger range of anisotropies (delta less than or similar to 0.5). These results are confirmed when we extend our analysis to 18 additional E/S0 galaxies observed with SAURON. The dynamical models indicate that the anisotropy inferred from the (V/sigma, epsilon) diagram is due to a flattening of the velocity ellipsoid in the meridional plane (sigma(R) > sigma(z)), which we quantify with the beta anisotropy parameter. We find a trend of increasing beta for intrinsically flatter galaxies. A number of the fast rotators show evidence for containing a flattened, kinematically distinct component, which in some cases counter-rotates relative to the main galaxy body. These components are generally more metal rich than the galaxy body. All these results support the idea that fast rotators are nearly oblate and contain disc-like components. The role of gas must have been important for their formation. The slow rotators are weakly triaxial. Current collisionless merger models seem unable to explain their detailed observed properties.
Nasal Epenthesis in Hindi

Abstract Modern Hindi words such as [dãt] ‘tooth’ and [t ∫ãnd] ‘moon’ had similar phonetic structure in Middle Indo-Aryan, with conventional transliterations of danta and čanda, respectively. The development of the long nasal vowel is usually correlated with loss of the nasal consonant. If so, why does one form still contain a nasal consonant? We argue that a sequence of nasalized vowel + voiced stop (but not voiceless stop) can, for phonetic reasons, engender an epenthetic nasal, and we demonstrate that the same process can be found (nondistinctively) in present-day Hindi and French in the junction between a word-final nasal vowel and a following word-initital voiced stop. A nondistinctive epenthetic nasal can become a ‘full’ or ‘lexical’ nasal when listeners reinterpret this transitional event as purposeful or intended.
Biochemical isolation of myonuclei employed to define changes to the myonuclear proteome that occur with aging

Skeletal muscle aging is accompanied by loss of muscle mass and strength. Examining changes in myonuclear proteins with age would provide insight into molecular processes which regulate these profound changes in muscle physiology. However, muscle tissue is highly adapted for contraction and thus comprised largely of contractile proteins making the nuclear proteins difficult to identify from whole muscle samples. By developing a method to purify myonuclei from whole skeletal muscle, we were able to collect myonuclei for analysis by flow cytometry, biochemistry, and mass spectrometry. Nuclear purification dramatically increased the number and intensity of nuclear proteins detected by mass spectrometry compared to whole tissue. We exploited this increased proteomic depth to investigate age‐related changes to the myonuclear proteome. Nuclear levels of 54 of 779 identified proteins (7%) changed significantly with age; these proteins were primarily involved in chromatin maintenance and RNA processing. To determine whether the changes we detected were specific to myonuclei or were common to nuclei of excitatory tissues, we compared aging in myonuclei to aging in brain nuclei. Although several of the same processes were affected by aging in both brain and muscle nuclei, the specific proteins involved in these alterations differed between the two tissues. Isolating myonuclei allowed a deeper view into the myonuclear proteome than previously possible facilitating identification of novel age‐related changes in skeletal muscle. Our technique will enable future studies into a heretofore underrepresented compartment of skeletal muscle.
Measurement of infant pulmonary mechanics: comparative analysis of techniques.

In spontaneously breathing, intubated infants, lung elastance (E) and resistance (R) can be derived from the general equation of motion of the lung, Ptp = E.V + R.V + I.V + K, where P is the pressure applied to the system, E is the elastance (the reciprocal of the compliance), V is the volume, R is the resistance to airflow (V), I is the inertance, (V) is gas acceleration, and K is a constant representing alveolar pressure. However, differences in the methods of analysis may results in variations in the derived values of E and R. Eighteen non-sedated intubated infants, with a mean post-conceptual age of 32.3 weeks and mean weight of 1.51 kg, were studied to compare values in E and R derived by 7 different methods of analysis. For each infant, the same 7 consecutive breaths were analyzed by the following methods: 1) linear regression of Ptp on tidal volume (VT); 2) a Mead-Whittenberger analysis, 3) a 2-factor linear regression of Ptp with (V) and VT; 4) a 3-factor regression of Ptp with V, VT, and V; 5) a 3-factor linear regression model of Ptp with V, VT, and a (V)2 factor (to incorporate a turbulent flow factor); 6) a 4-factor regression of Ptp with V, VT, V, and (V)2; and 7) a transformation regression plot of Ptp/VT versus V/VT. In addition, the lung impedance was calculated from the values of E and R derived by each method. There was no significant difference between the measurements of E and R in methods 2-6 (by MANCOVA, with the subjects being covariates). Methods 1 and 7 had a significantly elevated E; in addition, Method 7 also had an elevated R. Furthermore, there were no differences between the impedance values derived from the different methods. We conclude that in this group of spontaneously breathing, intubated infants with a spectrum of pathology, the results of a 2-factor regression analysis are comparable to more complex models of the mechanics of the lung.
Topological feedback entropy and Nonlinear stabilization

It is well known in the field of dynamical systems that entropy can be defined rigorously for completely deterministic open-loop systems. However, such definitions have found limited application in engineering, unlike Shannon's statistical entropy. In this paper, it is shown that the problem of communication-limited stabilization is related to the concept of topological entropy, introduced by Adler et al. as a measure of the information rate of a continuous map on a compact topological space. Using similar open cover techniques, the notion of topological feedback entropy (TFE) is defined in this paper and proposed as a measure of the inherent rate at which a map on a noncompact topological space with inputs generates stability information. It is then proven that a topological dynamical plant can be stabilized into a compact set if and only if the data rate in the feedback loop exceeds the TFE of the plant on the set. By taking appropriate limits in a metric space, the concept of local TFE (LTFE) is defined at fixed points of the plant, and it is shown that the plant is locally uniformly asymptotically stabilizable to a fixed point if and only if the data rate exceeds the plant LTFE at the fixed point. For continuously differentiable plants in Euclidean space, real Jordan forms and volume partitioning arguments are then used to derive an expression for LTFE in terms of the unstable eigenvalues of the fixed point Jacobian.
Help in the Choice of Automated or Semiautomated Immunoassays for Serological Diagnosis of Toxoplasmosis: Evaluation of Nine Immunoassays by the French National Reference Center for Toxoplasmosis

ABSTRACT Toxoplasmosis, a benign infection, is asymptomatic or paucisymptomatic in over 80% of cases, except in immunocompetent patients suffering from ocular toxoplasmosis or in immunocompromised patients with opportunistic or congenital toxoplasmosis. Diagnosis is based mainly on serology testing. Thus, we compared the performance of the nine most commonly used commercial automated or semiautomated immunoassays for IgG and IgM Toxoplasma gondii antibody detection, that is, the Advia Centaur, Architect, AxSYM, Elecsys, Enzygnost, Liaison, Platelia, VIDAS, and VIDIA assays. The assays were conducted on four panels of serum samples derived during routine testing from patients with an interfering disease and who exhibited a low IgG antibody level in one of two clinical settings, namely, acute or chronic toxoplasmosis. As a result, IgG sensitivities ranged from 97.1% to 100%, and IgG specificities ranged from 99.5% to 100%. For IgG quantification, strong differences in IgG titers (expressed in IU/ml) were noted depending on the assay used. IgM sensitivities ranged from 65% to 97.9%, and IgM specificities ranged from 92.6% to 100%. For defining the best serological strategies to be implemented, it appears crucial to compare the diagnostic performance of the different tests with respect to their specificity and sensitivity in detecting the presence of IgG and IgM antibodies.
Long-Term Treatment of Overweight and Obesity with Polyglucosamine (PG L112): Randomized Study Compared with Placebo in Subjects after Caloric Restriction

Abstract Background: Short-term treatment of overweight and obesity with polyglucosamine (PG) was found to be more effective than placebo and orlistat in double-blind clinical studies. Objective: The aim of the study was to compare the efficacy of long-term (12-mo) treatment of weight loss with PG and placebo (PL). Methods: This was a double-blind randomized study in 100 participants of both sexes with a body mass index (in kg/m2) >30 to <35. One group of 50 participants was treated for 1 y with PG at 1.6 g/d and a similar group received PL. PG is a combination of low-molecular-weight chitosan with organic acids. Participants were instructed to reduce their caloric intake by 10% and increase the physical activity level by 9 metabolic equivalent task hours/wk. Dietary compliance was checked every 3 mo by using a weekly questionnaire [food intake assessment (FIA)] based on 25 different food servings. Body weight (BW), waist circumference (WC), blood pressure (BP), glucose, lipids, and high-sensitivity C-reactive protein (hs-CRP) were also monitored. Results: Ninety-seven participants completed the study (49 in the PG group, 48 in the PL group). The decrease in calories was similar in both groups, as was the change in number of food servings (P > 0.05, ANOVA). Decreases in BW and WC were 8.0 kg and 10.2 cm, respectively, in the PL group, whereas they were 12.1 kg and 13.3 cm in the PG group (P < 0.001, ANOVA). The decrease in BP, plasma lipids, glucose, and hs-CRP was more evident in the group treated with PG (P < 0.05, ANOVA). The intake of lipids was found to correlate directly with hs-CRP, with the exception of extra-virgin olive oil. Conclusions: PG was found to be more effective than PL in reducing BW, WC, glucose, BP, plasma lipids, and hs-CRP in moderately obese individuals undergoing a 10% caloric reduction and a slight increase in physical activity. Dietary monitoring with the use of an FIA was an effective tool in supporting dietary compliance. This trial was registered at clinicaltrials.gov as U111111292405 (WHO).
A comparative pharmacokinetic and pharmacodynamic study of FSK0808 versus reference filgrastim after repeated subcutaneous administration in healthy Japanese men

FSK0808, a biosimilar of filgrastim, is a recombinant human granulocyte colony‐stimulating factor developed by Fuji Pharmaceuticals and Mochida Pharmaceutical Co., Ltd. We conducted a double‐blind, randomized, crossover study in healthy Japanese men, comparing the number of CD34‐positive cells (CD34+ cells) after repeated subcutaneous administration of either FSK0808 or the reference filgrastim (Gran®). As primary endpoints, we compared the maximum number of CD34+ cells (CD34+ Cmax) and the time to reach CD34+ Cmax (CD34+ tmax). As secondary endpoints, we compared the area under the curve for the number of CD34+ cells over time at the 410 hours time point (CD34+ AUC0–410), the parameters used to calculate the pharmacodynamic index of the absolute neutrophil count, and the pharmacokinetic parameters. Regarding the CD34+ Cmax and the CD34+ AUC0–410 values, the 95% confidence interval (CI) of the differences between the mean values for each drug was within the range of log(0.8)–log(1.25). With respect to the differences in the median values between drugs, the ratio against the reference filgrastim median value in the 95% CI was within the range of ± 0.2 for the CD34+ tmax value. From these results, we considered that these drugs display equivalent pharmacodynamic and pharmacokinetic properties.
Cultural and Situational Contingencies and the Theory of Reasoned Action: Application to Fast Food Restaurant Consumption

This study investigated the usefulness of the theory of reasoned action for fast food restaurant patronage decisions. The theory of reasoned action was found to generalize across four samples drawn from the United States ( N = 246), Italy ( N = 123), The People's Republic of China ( N = 264), and Japan ( N =419). However, predictions under the theory of reasoned action were found to vary, depending on the social setting (eating alone or eating with friends) and cultural orientation (independent vs. interdependent). Among other results, subjective norms were found to influence decisions when eating with friends, but not when alone; the effects of attitudes, subjective norms, and past behavior on intentions were greater for Americans than Italians, Chinese, or Japanese; and in general, more explained variance occurred for Western (American, Italian) than Eastern (Chinese, Japanese) cultures.
Breast Imaging in the Era of Big Data: Structured Reporting and Data Mining.

OBJECTIVE The purpose of this article is to describe structured reporting and the development of large databases for use in data mining in breast imaging. CONCLUSION The results of millions of breast imaging examinations are reported with structured tools based on the BI-RADS lexicon. Much of these data are stored in accessible media. Robust computing power creates great opportunity for data scientists and breast imagers to collaborate to improve breast cancer detection and optimize screening algorithms. Data mining can create knowledge, but the questions asked and their complexity require extremely powerful and agile databases. New data technologies can facilitate outcomes research and precision medicine.
Survey Development for Assessing Learning Identity in an ISLE Classroom

Innovative STEM curricula such as the ISLE (Investigative Science Learning Environment) curriculum [1] are centered on active engagement in social learning processes as a means to achieve curricular goals. Classroom practices are highly interactive to facilitate students’ development of authentic scientist abilities. To the students, these classroom practices often seem very different from their previous learning experiences in terms of behavioral expectations, attitude, and what it means to learn. Consequently, students must modify their identity as learners in addition to physics conceptual understanding in order to participate productively in this learning environment. Using a survey we developed, we want to assess their 1) expectations of student and teacher roles, 2) self efficacy towards skills supported in ISLE and 3) attitudes towards social learning as well as how these change as a result of their experience in this curriculum. We will discuss the development, validation and preliminary findings .
A Neural Network based Facial Expression Recognition using Fisherface

expression plays significant role for human beings to communicate their emotions. Automatic facial expression analysis is a flourishing area of research in computer science, and it is also still a challenge. This paper discusses the application of a natural network based facial expression recognition using fisherface. Back propagation neural network is used as a classifier for classifying the expressions. For face portion segmentation and localization, integral projection method is used. The accuracy of system performance have evaluated on a public database "Japanese Female Facial Expression (JAFFE)". The experimental results show the effectiveness of our scheme. The best average recognition rate achieves 89.20%.
Time Preferences and Lifetime Outcomes

This paper investigates the relationship between time preferences and lifetime social and economic behavior. We use a Swedish longitudinal dataset that links information from a large survey on children’s time preferences at age 13 to administrative registers spanning over four decades. Our results indicate a substantial adverse relationship between high discount rates and school performance, health, labor supply, and lifetime income. Males and high ability children gain significantly more from being future-oriented. These discrepancies are largest regarding outcomes later in life. We also show that the relationship between time preferences and long-run outcomes operates through early human capital investments.
Promoting positive attitudes towards foreign language learning: a New Zealand initiative

Abstract This paper reports on the effectiveness of a tailored undergraduate course at a tertiary institution in New Zealand constructed to challenge, and encourage changes to, monolingual ‘English-only’ attitudes. The course was designed to provide knowledge and promote understanding of the phenomenon of English as a global language, and the place of, and implications for, languages other than English in that context. Working with two cohorts of students, a pre- and post-treatment design was used whereby participants completed an attitudinal questionnaire at the start of the course and the same questionnaire at the end. They were also asked what they thought about languages in a globalised world. The questionnaires were analysed to determine if there had been any shift in attitudes by the end of the course. Findings are presented and discussed in terms of the effectiveness of this course to promote positive attitudes towards foreign language learning in New Zealand-based students. It raises the question of whether similar courses could be planned for use by secondary and other tertiary students as part of initiatives to help them to recognise that speaking languages other than English is normative in today's world.
Pediatric genetic disease of the cornea

Abstract Our objective is to evaluate the literature regarding selected genetic diseases of the cornea, including megalocornea, keratoglobus, keratoconus, cystinosis, the mucopolysaccharidoses, sclerocornea, Peters' anomaly, familial dysautonomia, and various corneal dystrophies. The transparency of the cornea is a consequence of uniformity in both size and spacing of the collagen lamellae. The cornea's clarity depends on a delicate biochemical and structural balance; consequently, genetic disorders that disrupt either its metabolic or anatomic function can cause opacity and vision loss. Many childhood corneal diseases have a genetic etiology and are associated with known syndromes. Each disorder has unique associated set of possible complications. Prognosis often depends on the extent of opacity and disorganization of the anterior segment. Corneal transplantation has been performed for these disorders with variable success.
LAPTM4B Allele *2 Is Associated with Breast Cancer Susceptibility and Prognosis

Background Lysosome-associated protein transmembrane 4 beta (LAPTM4B) has two alleles named LAPTM4B*1 and LAPTM4B*2. Allele *1 contains only one copy of a 19-bp sequence at the 5′UTR in the first exon, whereas this sequence of allele*2 is duplicated and arrayed as a tandem repeat. Previous studies revealed that LAPTM4B polymorphisms contribute to the risk of certain types of cancers. This study aimed to investigate the polymorphism of LAPTM4B in breast cancer by analysis the correlation of LAPTM4B genotype with breast cancer susceptibility, clinicopathologic features and prognosis. Methods Genotyping of the LAPTM4B polymorphism was determined by PCR method. The expression levels of LAPTM4B in breast cancer tissues and breast cancer cell lines were determined by quantitative reverse-transcription PCR (qRT-PCR) analysis. The correlation of LAPTM4B genotype with clinicopathologic parameters and prognosis were assessed statistically. Results The results of qRT-PCR analysis indicated that LAPTM4B*2 was associated with the higher level of LAPTM4B expression compared with the LAPTM4B*1 in both breast cancer cell lines and breast cancer tissues. We found that LAPTM4B*2 was associated with an increased risk for breast cancer. LAPTM4B*2 was significantly associated with higher histopathologic grade, lymph node metastasis and poor prognosis. Conclusion LAPTM4B*2 is a risk factor associated with breast cancer susceptibility and poor prognosis. LAPTM4B*2 may be a potential predicative marker for the susceptibility, progression and metastasis of breast cancer.
Engendering migrant networks: The case of Mexican migration

This article compares the impact of family migrant and destination-specific networks on international and internal migration. We find that migrant networks are more important for international moves than for internal moves and that female networks are more important than male networks for moves within Mexico. For moves to the United States, male migrant networks are more important for prospective male migrants than for female migrants, and female migrant networks lower the odds of male migration, but significantly increase female migration. We suggest that distinguishing the gender composition and destination content of migrant networks deepens our understanding of how cumulative causation affects patterns of Mexican migration.
Connection to Nature and Psychological Resilience

Abstract This study focused on whether one's perceived connection to the natural world correlates with one's subjective sense of psychological resilience. Analysis of survey questionnaire responses of 150 participants from a major metropolitan area of the Pacific Northwest yielded a moderate positive correlation between scores on the Connectedness to Nature Scale and the Resilience Scale for the entire sample. Results varied by data collection site, suggesting socioeconomic status as a possible moderating variable. Generalizability of these results is limited by self-selection bias and underrepresentation of certain segments of the population. Results are considered within the context of community mental health leadership.