Miracle-dz/UniFAR-FTUs huggingface dataset:
Room-temperature single-photon sources with definite circular and linear polarizations based on single-emitter fluorescence in liquid crystal hosts

Definite circular and linear polarizations of room-temperature single-photon sources, which can serve as polarization bases for quantum key distribution, are produced by doping planar-aligned liquid crystal hosts with single fluorescence emitters. Chiral 1-D photonic bandgap microcavities for a single handedness of circularly polarized light were prepared from both monomeric and oligomeric cholesteric liquid crystals. Fluorescent emitters, such as nanocrystal quantum dots, nitrogen vacancy color centers in nanodiamonds, and rare-earth ions in nanocrystals, were doped into these microcavity structures and used to produce circularly polarized fluorescence of definite handedness. Additionally, we observed circularly polarized resonances in the spectrum of nanocrystal quantum dot fluorescence at the edge of the cholesteric microcavity's photonic stopband. For this polarization we obtained a ~4.9 enhancement of intensity compared to the polarization of the opposite handedness that propagates without photonic bandgap microcavity effects. Such a resonance is indicative of coupling of quantum dot fluorescence to the cholesteric microcavity mode. We have also used planar-aligned nematic liquid crystal hosts to align DiI dye molecules doped into the host, thereby providing a single-photon source of linear polarization of definite direction. Antibunching is demonstrated for fluorescence of nanocrystal quantum dots, nitrogen vacancy color centers, and dye molecules in these liquid crystal structures.
Functional brain imaging in apraxia.

BACKGROUND An extensive literature describes structural lesions in apraxia, but few studies have used functional neuroimaging. We used positron emission tomography (PET) to characterize relative cerebral glucose metabolism in a 65-year-old, right-handed woman with progressive decline in ability to manipulate objects, write, and articulate speech. OBJECTIVE To characterize functional brain organization in apraxia. DESIGN AND METHODS The patient underwent a neurological examination, neuropsychological testing, magnetic resonance imaging, and fludeoxyglucose F 18 PET. The patient's magnetic resonance image was coregistered to her PET image, which was compared with the PET images of 7 right-handed, healthy controls. Hemispheric regions of interest were normalized by calcrine cortex. RESULTS Except for apraxia and mild grip weakness, results of the neurological examination were normal. There was ideomotor apraxia of both hands (command, imitation, and object) and buccofacial apraxia. The patient could recognize meaningful gestures performed by the examiner and discriminate between his accurate and awkward pantomime. The magnetic resonance image showed moderate generalized atrophy and mild ischemic changes. Positron emission tomographic scans showed abnormal fludeoxyglucose F 18 uptake in the posterior frontal, supplementary motor, and parietal regions, the left affected more than the right. Focal metabolic deficit was present in the angular gyrus, an area hypothesized to store conceptual knowledge of skilled movement. CONCLUSIONS Greater parietal than frontal physiological dysfunction and preserved gesture recognition are not consistent with the theory that knowledge of limb praxis is stored in the dominant parietal cortex. Gesture comprehension may be more diffusely distributed.
Bayesian stochastic modeling of a spherical rock bouncing on a coarse soil

Abstract. Trajectory analysis models are increasingly used for rockfall hazard mapping. However, classical approaches only partially account for the variability of the trajectories. In this paper, a general formulation using a Taylor series expansion is proposed for the quantification of the relative importance of the different processes that explain the variability of the reflected velocity vector after bouncing. A stochastic bouncing model is obtained using a statistical analysis of a large numerical data set. Estimation is performed using hierarchical Bayesian modeling schemes. The model introduces information on the coupling of the reflected and incident velocity vectors, which satisfactorily expresses the mechanisms associated with boulder bouncing. The approach proposed is detailed in the case of the impact of a spherical boulder on a coarse soil, with special focus on the influence of soil particles' geometrical configuration near the impact point and kinematic parameters of the rock before bouncing. The results show that a first-order expansion is sufficient for the case studied and emphasize the predominant role of the local soil properties on the reflected velocity vector's variability. The proposed model is compared with classical approaches and the interest for rockfall hazard assessment of reliable stochastic bouncing models in trajectory simulations is illustrated with a simple case study.
Intravenous maternal hydration in third trimester oligohydramnios: effect on amniotic fluid volume.

OBJECTIVE To determine the affect of acute intravenous maternal hydration on amniotic fluid volume in patients with third trimester oligohydramnios. STUDY DESIGN Quasi experimental study. PLACE AND DURATION OF STUDY Department of Obstetrics and Gynaecology Unit III, Sir Ganga Ram Hospital, Lahore, from May 2001 to April 2002. PATIENTS AND METHODS Twenty-five women with third trimester oligohydramnios (AFI < or = 5.0 cm) and 25 controls with normal amniotic fluid volume (AFI 8-24 cm) were prospectively recruited for this study. Study inclusion criteria were, singleton pregnancy, well-established gestational age, intact membranes, absence of maternal complication (anemia, cardiac disease, renal disease, pre-eclampsia, hypertension, or diabetes); absence of fetal structural malformation and/or distress. Maternal urinary specific gravity and amniotic fluid index were determined before and after intravenous hydration by infusing 2 liters of 5% dextrose water in 2 hours and recorded on printed proformas. Sample independent 't' test was used to compare the mean AFI and urine specific gravity before and after treatment, and the posttreatment AFI--pre-treatment AFI ( delta AFI). RESULTS Maternal hydration increased amniotic fluid volume (AFV) in women with oligohydramnios (mean change in amniotic fluid index 4.5 cm, 95% confidence interval 4.02 to 5.06; p-value<0.01); as well as in women with normal amniotic fluid volume (mean change in amniotic fluid index 2.7 cm, 95% confidence interval 2.23 to 3.21; p-value<0.01). The percentage increase in mean AFI was 58.6% in the oligohydramnios group, which was significantly greater (p<0.05) than the percentage increase of 28.4% in control group. Maternal hydration was associated with decrease in urinary specific gravity in both groups. CONCLUSION Under the conditions of this study, maternal (intravenous) hydration increased the AFV in women with oligohydramnios as well as in those with normal AFV and may be beneficial in the management of oligohydramnios.
Reliability/Validity of the Fortius Trainer

This study examined the reliability/validity of power output measured using the Fortius Virtual Reality cycle trainer. 10 cyclists (age: 28±6 years; V˙O (2)max: 60.9±7.2 ml · kg (-1) · min (-1); peak power: 393±82 W) completed three 20 km time trials on a Fortius cycle trainer. During each time trial, power output was measured at 1 Hz using the Fortius internal software and a PowerTap power monitor. Validity calculated for the Fortius trainer; Pearson correlation coefficient (r=0.99; 95% CI: 0.98-0.99; p<0.01) and typical error of estimate (3.5%; 95% CI: 3.2-3.9%), was similar to other established laboratory ergometers. No differences (F (2,16)=0.32; p=0.73) in mean 20 km power were observed between trial 1 (253±46 W), 2 (258±49 W), or 3 (255±50 W). Test-retest reliability (intraclass correlation coefficient (ICC) and coefficient of variation (CV)) was better between trial 2 and 3 (ICC=1.00 (CI: 0.98-1.00); CV: 1.6% (CI: 1.1-3.3%)) compared with trial 1 and 2 (ICC=0.98 (CI: 0.91-1.00); CV: 3.3% (CI: 2.2-6.4%)). The Fortius cycle trainer is a valid and reliable device for the measurement of power output in cyclists, thus providing an alternative to larger more expensive laboratory ergometers.
A four-dimensional population module for the analysis of future adaptive capacity in the Phang Nga province of Thailand

In this paper we describe an innovative aspect of the population module in the context of an ongoing comprehensive modelling effort to assess future populationenvironment interactions through specific case studies. A particular focus of our study is the vulnerability of coastal populations to environmental factors and their future adaptive capacity. Based on the four-dimensional cross-classification of populations by age, sex, level of education, and labour force participation, our approach builds on a recent body of research that has critically assessed the role of demographic differentials as determinants of differential vulnerability and adaptive capacity. We use Phang Nga, a province in the south of Thailand that was severely affected by the tsunami in 2004, to describe current levels of educational attainment and investigate past trends, which in turn serve as input for detailed education projections. These education projections, in combination with projections of economic activity and household survey results about disaster preparedness, feed into further analysis of future adaptive capacity. Given our specifications and assumptions, we find that the educational composition of the province’s labour force will shift towards higher levels, and that the population of Phang Nga will be better prepared for future disasters.
On Evaluation and Training-Set Construction for Duplicate Detection

A variety of experimental methodologies have been used to evaluate the accuracy of duplicate-detection systems. We advocate presenting precision-recall curves as the most informative evaluation methodology. We also discuss a number of issues that arise when evaluating and assembling training data for adaptive systems that use machine learning to tune themselves to specific applications. We consider several different application scenarios and experimentally examine the effectiveness of alternative methods of collecting training data under each scenario. We propose two new approaches to collecting training data called static-active learning and weaklylabeled non-duplicates, and present experimental results on their effectiveness.
An implementation of light-weight compression algorithm for wireless sensor network technology in structure health monitoring

Internet-of-Thing (IoT) has been identified as one of the next generation technologies from different aspects. Among different technologies for IoT, wireless-sensor-network (WSN) is one of key technologies to be developed. To demonstrate WSN capabilities in applications, this work developed self-developed sensor node (Super-Node) and applied the device into an on-field structure-health-monitoring (SHM) task. The developed WSN system achieved requirements of SHM applications, i.e. 128 Hz sampling rate with tri-axial acceleration data within one sensor node. By acquired data, the developed system can make the prediction of structure status. In addition, a local-data-processing node and algorithm was also implemented to promote usability of WSN system in SHM applications. With Huffman code implemented, the wireless transmission payload was reduced by 60% and the node capacity can be increased by 3 times. This work not only demonstrated the capability of WSN technologies in on-field SHM applications but also provided a better solution for IoT development.
Surface-bounded growth modeling applied to human mandibles

From a set of longitudinal three-dimensional scans of the same anatomical structure, the authors have accurately modeled the temporal shape and size changes using a linear shape model. On a total of 31 computed tomography scans of the mandible from six patients, 14,851 semilandmarks are found automatically using shape features and a new algorithm called geometry-constrained diffusion. The semilandmarks are mapped into Procrustes space. Principal component analysis extracts a one-dimensional subspace, which is used to construct a linear growth model. The worst case mean modeling error in a cross validation study is 3.7 mm.
Methanol-based fixation is superior to buffered formalin for next-generation sequencing of DNA from clinical cancer samples

High-quality tumour DNA is essential for any personalised treatment strategy based on NGS. Here we show that methanol fixation is superior to formalin, greater DNA yield, longer fragment size and more accurate copy-number calling using sWGS. We also show provide a new approach to understand fixation artefacts using non-negative matrix factorization.
Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction

Background The DSM-V Working Group is currently re-evaluating distress as a primary diagnostic criterion for female sexual dysfunction (FSD). Here, for the first time, we explored the epidemiology of sexual distress and its putative aetiological relationship to FSD by estimating the influence of genetic and environmental risk factors. Method Questionnaire data on a representative sample of 930 British female twins using validated scales of FSD and sexual distress were subject to variance components analyses to quantify latent genetic and environmental factors influencing phenotypic variation and covariation. Multiple regression analyses were used to identify other potential risk factors of sexual distress. Results Of 319 women with any sexual problems, only 36.5% reported distress. Of women classified as functional, 16.5% felt sexual distress. Sexual distress had a heritability of 44% [95% confidence interval (CI) 0.33–0.54]. Bivariate analysis suggested that the majority (91% CI 86–99%) of the covariance between sexual distress and FSD was due to unique environmental effects common to both traits. Associations were found between sexual distress and other risk variables, including relationship dissatisfaction [odds ratio (OR) 1.6, p<0.001], anxiety sensitivity and obsessive–compulsive symptomatology (OR 1.2, p<0.01, for both). Conclusions There seems to be a weak phenotypic and genetic basis for including sexual distress as a diagnostic indicator of FSD. Instead, the data indicate that unrelated psychological factors play an important role in sexual distress and tentatively suggest that sexual distress is less a consequence of FSD and more related to general anxiety among women.
The Lung Function Impairment in Non-Atopic Patients With Chronic Rhinosinusitis and Its Correlation Analysis

Objectives Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been much studied. Methods One hundred patients with CRS with nasal polyps (CRSwNP group), 40 patients with CRS without nasal polyps (CRSsNP group), and 100 patients without CRS were enrolled. The difference in lung function was compared. Meanwhile, CRSwNP and CRSsNP group were required to undergo a bronchial provocation or dilation test. Additionally, subjective and objective outcomes were measured by the visual analogue scale (VAS), 20-item Sino-Nasal Outcome Test (SNOT-20), Lund-Mackay score, Lund-Kennedy endoscopic score. The correlation and regression methods were used to analyze the relationship between their lung function and the above parameters. Results The forced expiratory volume in 1 second (FEV1) and forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) of CRSwNP group were significantly lower than other groups (P<0.05). On peak expiratory flow, there was no difference between three groups. In CRSwNP group, FEV1 was negatively correlated with peripheral blood eosinophil count (PBEC) and duration of disease (r=–0.348, P=0.013 and r=–0.344, P=0.014, respectively), FEF25-75 negatively with VAS, SNOT-20 (r=–0.490, P=0.028 and r=–0.478, P=0.033, respectively) in CRSsNP group. The incidence of positive bronchial provocation and dilation test was lower in CRSwNP group (10% and 0%, respectively), with both 0% in CRSsNP group. The multiple linear regression analysis indicated that change ratio of FEV1 before and after bronchial provocation or dilation test were correlated with PBEC in CRSwNP group (β=0.403, P=0.006). Conclusion CRS leading to impaired maximum ventilation and small airway is associated with the existence of nasal polyp. Lung function impairments can be reflected by PBEC, duration, VAS, and SNOT-20. In CRSwNP patients, PBEC is independent predictor of FEV1 change ratio.
Spider bite (latrodectism) in Mashhad, Iran

Background: Spider (Latrodectus tredecimguttatus) bites are relatively common in North East Iran. They induce morbidity and rarely mortality. We aimed to investigate clinical, electrocardiographic and para-clinical changes in patients with this bite. Methods: All consecutive patients admitted with suspected spider bites between September 2005 and September 2006 were studied prospectively. Results: Spider bites accounted for 56 cases (0.5% of all poisoning, 21% of all admitted envenomated). The patients’ mean (SD) age was 32 (16) years. The most common findings were pain (90%) mainly in their back (45%), stomach (35%), lower limbs (33%), upper limbs (19%) and chest (14%). Other clinical findings included were sweating (55%), chills (29%), dyspnea (25%), flushing (14%), spasm (12%), headache (12%), nausea (12%) and vertigo (12%). On electrocardiograph (ECG); ST segments were depressed in 25% of cases in at least two of the pre-cordial leads. Laboratory findings were in normal ranges. All the patients recovered following supportive and symptomatic treatment (no anti-toxin available in Iran), with a mean hospitalization period of 1.9 (1.3) days. Conclusions: Spider (L. Tredecimguttatus) bite is relatively common in Mashhad, which induces latrodectism with relatively different findings and cardiac toxicity. ECG monitoring should be considered, particularly when specific anti-toxin is not available.
A parametric texture model based on deep convolutional features closely matches texture appearance for humans

Our visual environment is full of texture—“stuff” like cloth, bark or gravel as distinct from “things” like dresses, trees or paths—and humans are adept at perceiving subtle variations in material properties. To investigate image features important for texture perception, we psychophysically compare a recent parameteric model of texture appearance (CNN model) that uses the features encoded by a deep convolutional neural network (VGG-19) with two other models: the venerable Portilla and Simoncelli model (PS) and an extension of the CNN model in which the power spectrum is additionally matched. Observers discriminated model-generated textures from original natural textures in a spatial three-alternative oddity paradigm under two viewing conditions: when test patches were briefly presented to the near-periphery (“parafoveal”) and when observers were able to make eye movements to all three patches (“inspection”). Under parafoveal viewing, observers were unable to discriminate 10 of 12 original images from CNN model images, and remarkably, the simpler PS model performed slightly better than the CNN model (11 textures). Under foveal inspection, matching CNN features captured appearance substantially better than the PS model (9 compared to 4 textures), and including the power spectrum improved appearance matching for two of the three remaining textures. None of the models we test here could produce indiscriminable images for one of the 12 textures under the inspection condition. While deep CNN (VGG-19) features can often be used to synthesise textures that humans cannot discriminate from natural textures, there is currently no uniformly best model for all textures and viewing conditions.
Active Balancing System for Electric Vehicles With Incorporated Low-Voltage Bus

Electric-drive vehicles, including hybrid, plug-in hybrid, and electric vehicles, require a high-voltage (HV) battery pack for propulsion and a low-voltage (LV) dc bus for auxiliary loads. This paper presents an architecture that uses modular dc-dc bypass converters to perform active battery cell balancing and to supply current to auxiliary loads, eliminating the need for a separate HV-to-LV high step-down dc-dc converter. The modular architecture, which achieves continuous balancing of all cells, can be used with an arbitrary number of cells in series, requires no control communication between converters, and naturally shares the auxiliary load current according to the relative state-of-charge (SOC) and capacities of the battery cells. Design and control details are provided for LV low-power dual active bridge (DAB) power converters serving as the bypass converter modules. Furthermore, current sharing is examined and worst-case SOC and current deviations are derived for mismatches in cell capacities, SOCs, and parasitic resistances. Experimental results are presented for a system consisting of 21 series 25 Ah Panasonic lithium-ion NMC battery cells and 21 DAB bypass converters, with combined outputs rated to supply a 650-W auxiliary load.
Investigational CETP antagonists for hyperlipidemia and atherosclerosis prevention

Introduction: Reverse cholesterol transport (RCT) is a function of high-density lipoproteins (HDL) in humans and higher species. It is enabled by the cholesteryl ester transfer protein (CETP), a high molecular weight protein exchanging cholesteryl esters in HDL for triglycerides in very low-density lipoproteins (VLDL). Inhibition of CETP may provide a useful strategy to raise HDL, the protective lipoprotein fraction in plasma. Areas covered: Evaluation based on clinical and experimental findings of the three drugs developed or in advanced development for CETP inhibition. Expert opinion: Inhibition of CETP, both inherited and drug induced, at times leads to dramatic elevations of HDL-cholesterol (HDL-C) levels. Epidemiological data presently available do not, however, provide convincing evidence that reduced CETP levels or activity due to genetic factors and associated with HDL-C elevations, reduce cardiovascular risk. Indeed, the opposite may be true in some instances. All the three CETP inhibitors were the object of experimental and clinical evaluation. Large clinical trials with torcetrapib led to very negative findings, that is, raised cardiovascular morbidity and mortality in addition to raised risk of cancer and sepsis. Off-target effects of the drug, such as aldosterone retention and raised blood pressure, were believed to provide an explanation for these negative findings. The two newer agents, dalcetrapib and anacetrapib, do not exert off-target effects. The two drugs differ because anacetrapib has a more dramatic effect on HDL cholesterolemia (+139%) versus more moderate effects of dalcetrapib (+20–30%). Anacetrapib, however, may impair formation of pre-β HDL, that is, the primary particles in the process of cholesterol removal. The initial large trial with anacetrapib (DEFINE study) in coronary patients on statin treatment, appeared to confirm a remarkable HDL raising property, together with some reduction in vascular end points, in particular coronary procedures. The issue of other potentially harmful effects of CETP inhibition (sepsis and others) has yet to be clarified. Large clinical end-point trials, however, will be necessary to provide convincing evidence that, in addition to raising HDL-C, CETP inhibitors provide a valid additional treatment, for example, to statins in patients with coronary heart disease (CHD) or at high risk of CHD.