Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study.

BACKGROUND Tobacco, alcohol and caffeine consumption may influence risk of uterine leiomyomata via changes in ovarian function or hormone metabolism. METHODS We prospectively assessed the relation of these exposures to risk of self-reported uterine leiomyomata in the Black Women's Health Study. From 1997 to 2001, we followed 21,885 premenopausal women with intact uteri and no prior myoma diagnosis. Cox regression models were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs). RESULTS During 73,426 person-years of follow-up, 2177 incident cases of uterine leiomyomata confirmed by ultrasound (n = 1920) or hysterectomy (n = 257) were reported. Cigarette smoking was not associated with risk of uterine leiomyomata. Risk was positively associated with years of alcohol consumption and current consumption of alcohol, particularly beer. Relative to non-drinkers, multivariate IRRs for beer consumption of < 1, 1-6 and 7+ drinks/week were 1.11 (95% CI 0.98-1.27), 1.18 (95% CI 1.00-1.40) and 1.57 (95% CI 1.17-2.11), respectively. Heavy coffee and caffeine consumption were not associated with risk overall, but IRRs were increased among women aged < 35 years. CONCLUSIONS In US black women, risk of uterine leiomyomata was positively associated with current consumption of alcohol, particularly beer. Cigarette smoking and caffeine consumption were unrelated to risk overall.
Active Use of Electronic Health Records (EHRs) and Personal Health Records (PHRs) for Epidemiologic Research: Sample Representativeness and Nonresponse Bias in a Study of Women During Pregnancy

Introduction: With the growing use of electronic medical records, electronic health records (EHRs), and personal health records (PHRs) for health care delivery, new opportunities have arisen for population health researchers. Our objective was to characterize PHR users and examine sample representativeness and nonresponse bias in a study of pregnant women recruited via the PHR. Design: Demographic characteristics were examined for PHR users and nonusers. Enrolled study participants (responders, n=187) were then compared with nonresponders and a representative sample of the target population. Results: PHR patient portal users (34 percent of eligible persons) were older and more likely to be White, have private health insurance, and develop gestational diabetes than nonusers. Of eligible persons (all PHR users), 11 percent (187/1,713) completed a self-administered PHR based questionnaire. Participants in the research study were more likely to be non-Hispanic White (90 percent versus 79 percent) and married (85 percent versus 77 percent), and were less likely to be Non-Hispanic Black (3 percent versus 12 percent) or Hispanic (3 percent versus 6 percent). Responders and nonresponders were similar regarding age distribution, employment status, and health insurance status. Demographic characteristics were similar between responders and nonresponders. Discussion: Demographic characteristics of the study population differed from the general population, consistent with patterns seen in traditional population-based studies. The PHR may be an efficient method for recruiting and conducting observational research with additional benefits of efficiency and cost-cost-effectiveness.
Spectral controllability for 2D and 3D linear Schrödinger equations

We consider a quantum particle in an infinite square potential well of ℝ<sup>n</sup>, n = 2; 3, subjected to a uniform electric field in space. Under the dipolar moment approximation, the wave function solves a PDE of Schrödinger type. We study the spectral controllability in finite time of the linearized system around the ground state. We characterize one necessary condition for spectral controllability in finite time: (Kal) if Ω is the bottom of the well, then for every eigenvalue λ of Δ<sup>D</sup><inf>Ω</inf> the projections of the dipolar moment onto every (normalized) eigenvector associated to λ are linearly independent in ℝ<sup>n</sup>.
Deligne's conjecture on 1-motives

We reformulate a conjecture of Deligne on 1-motives by using the integral weight filtration of Gillet and Soule on cohomology, and prove it. This implies the original conjecture up to isogeny. If the degree of cohomology is at most two, we can prove the conjecture for the Hodge realization without isogeny, and even for 1-motives with torsion.
Modeling, Verification and Testing of P Systems Using Rodin and ProB

Summary. In this paper we present an approach to modelling, veriflcation and testing for cell-like P-systems based on Event-B and the Rodin platform. We present a general framework for modelling P systems using Event-B, which we then use to implement two P-system models in the Rodin platform. For each of the two models, we use the associated Pro-B model checker to verify properties and we present some of the results obtained.
Observable subspaces for 3D human motion recovery

The articulated body models used to represent human motion typically have many degrees of freedom, usually expressed as joint angles that are highly correlated. The true range of motion can therefore be represented by latent variables that span a low-dimensional space. This has often been used to make motion tracking easier. However, learning the latent space in a problem- independent way makes it non trivial to initialize the tracking process by picking appropriate initial values for the latent variables, and thus for the pose. In this paper, we show that by directly using observable quantities as our latent variables, we eliminate this problem and achieve full automation given only modest amounts of training data. More specifically, we exploit the fact that the trajectory of a person's feet or hands strongly constrains body pose in motions such as skating, skiing, or golfing. These trajectories are easy to compute and to parameterize using a few variables. We treat these as our latent variables and learn a mapping between them and sequences of body poses. In this manner, by simply tracking the feet or the hands, we can reliably guess initial poses over whole sequences and, then, refine them.
Accretion dynamics in neutron star black hole binaries

We perform three-dimensional, Newtonian hydrodynamic simulations with a nuclear equation of state to investigate the accretion dynamics in neutron star black hole systems. We find as a general result that non-spinning donor stars yield larger circularization radii than corotating donors. Therefore, the matter from a neutron star without spin will more likely settle into an accretion disk outside the Schwarzschild radius. With the used stiff equation of state we find it hard to form an accretion disk that is promising to launch a gamma-ray burst. In all relevant cases the core of the neutron star survives and keeps orbiting the black hole as a mini neutron star for the rest of the simulation time (up to several hundred dynamical neutron star times scales). The existence of this mini neutron star leaves a clear imprint on the gravitational wave signal which thus can be used to probe the physics at supra-nuclear densities.
Clinical radiological aspects of primary endodontic lesions with secondary periodontal involvement

Damage of pulp tissue usually begins in the coronal pulp. Its mistreatment or its lack of on time detection determines the progressive inclusion of the whole endodontic space in its evolution, opening the way of its expansion in the surrounding tissues of the tooth, and on the marginal apical tissue. Aim. The goal of this study was to highlight that the primary endodontic lesions with secondary periodontal implication healed and bone repair was obtained due to a proper disinfection and an adequate sealing of the endodontic system. In primary endodontic lesion with secondary periodontal involvement, endodontic treatment is required in the first stage followed by specific periodontal treatment. The prognosis is good if an appropriate endodontic approach is chosen, depending on the stage of the periodontal disease and the treatment response. The identification of the etiological factors is the most important to establish the appropriate treatment. In all clinical cases selected in this article, the healing tendency was noticed after an adequate disinfection and sealing of the endodontic system.
FOREVER ALONE? TESTING SINGLE ECCENTRIC PLANETARY SYSTEMS FOR MULTIPLE COMPANIONS

Determining the orbital eccentricity of an extrasolar planet is critically important for understanding the system's dynamical environment and history. However, eccentricity is often poorly determined or entirely mischaracterized due to poor observational sampling, low signal-to-noise, and/or degeneracies with other planetary signals. Some systems previously thought to contain a single, moderate-eccentricity planet have been shown, after further monitoring, to host two planets on nearly circular orbits. We investigate published apparent single-planet systems to see if the available data can be better fit by two lower-eccentricity planets. We identify nine promising candidate systems and perform detailed dynamical tests to confirm the stability of the potential new multiple-planet systems. Finally, we compare the expected orbits of the single- and double-planet scenarios to better inform future observations of these interesting systems.
Prenatal Drug Exposure Affects Neonatal Brain Functional Connectivity

Prenatal drug exposure, particularly prenatal cocaine exposure (PCE), incurs great public and scientific interest because of its associated neurodevelopmental consequences. However, the neural underpinnings of PCE remain essentially uncharted, and existing studies in school-aged children and adolescents are confounded greatly by postnatal environmental factors. In this study, leveraging a large neonate sample (N = 152) and non-invasive resting-state functional magnetic resonance imaging, we compared human infants with PCE comorbid with other drugs (such as nicotine, alcohol, marijuana, and antidepressant) with infants with similar non-cocaine poly drug exposure and drug-free controls. We aimed to characterize the neural correlates of PCE based on functional connectivity measurements of the amygdala and insula at the earliest stage of development. Our results revealed common drug exposure-related connectivity disruptions within the amygdala–frontal, insula–frontal, and insula–sensorimotor circuits. Moreover, a cocaine-specific effect was detected within a subregion of the amygdala–frontal network. This pathway is thought to play an important role in arousal regulation, which has been shown to be irregular in PCE infants and adolescents. These novel results provide the earliest human-based functional delineations of the neural-developmental consequences of prenatal drug exposure and thus open a new window for the advancement of effective strategies aimed at early risk identification and intervention.
High-Tech Tools for Teaching Physics: the Physics Education Technology Project

This paper introduces a new suite of computer simulations from the Physics Education Technology (PhET) project, identifies features of these educational tools, and demonstrates their utility. We compare the use of PhET simulations to the use of more traditional educational resources in lecture, laboratory, recitation and informal settings of introductory college physics. In each case we demonstrate that simulations are as productive, or more productive, for developing student conceptual understanding as real equipment, reading resources, or chalk-talk lectures. We further identify six key characteristic features of these simulations that begin to delineate why these are productive tools. The simulations: support an interactive approach, employ dynamic feedback, follow a constructivist approach, provide a creative workplace, make explicit otherwise inaccessible models or phenomena, and constrain students productively.
Typed Unification Grammars

We introduce TFS, a computer formalism in the class of logic formalisms which integrates a powerful type system. Its basic data structures are typed feature structures. The type system encourages an object-oriented approach to linguistic description by providing a multiple inheritance mechanism and an inference mechanism which allows the specification of relations between levels of linguistic description defined as classes of objects. We illustrate this approach starting from a very simple DCG, and show how to make use of the typing system to enforce general constraints and modularize linguistic descriptions, and how further abstraction leads to a HPSG-like grammar.
A Sad Story is Not a Legal Defense: Defining Legal Issues

Those who work in the legal system are often viewed negatively as unhelpful and unsympathetic to those in need of legal assistance. Applicants seeking help from legal personnel feel disdain for the legal process because their expectations are not satisfied. This study examines how the communication processes between people seeking legal assistance and legal personnel contribute to an asymmetrical relationship in which the legal process feels inaccessible to prospective clients. Specifically, this study looks at the how prospective clients’ narratives are redefined to be a legally relevant narrative using legal definitions and categories at Colorado Legal Services. I discuss three main processes at Colorado Legal Services that work to redefine applicant narratives to fit legal procedure and the reasons why applicants don’t understand this legal structure. I conclude by offering recommendations that would remedy the communication between Colorado Legal Services’ staff and applicants and that would increase applicants’ comprehensibility of legal procedure.
On Group- learning

Group -learning is one of the teaching styles in distance education of TV university. It serves for the teaching with other styles such as self-learning, invidual assistant, face-to-face classes and classes on net. In this paper, the author analyzes the characters and the roles. From this aspect the writer also give out other related opinions on teaching methods,the orqnization and guiding of group-learning.
Nutrient-induced spatial patterning of human duodenal motor function.

The spatiotemporal patterning of duodenal motor function has been evaluated comprehensively for the first time in humans, with a novel 21-lumen manometric assembly. In nine young, healthy volunteers (6 male, 3 female), duodenal motility was recorded during fasting and three 45-min intraduodenal (ID) nutrient infusion periods (Intralipid at 0.25, 0.5, and 1.5 kcal/min). Pressures were recorded along the length of the duodenum with an array of 18 sideholes at 1.5-cm intervals. Pressure patterns were compared for the final 20 min of each of the four periods. Compared with fasting, ID lipid was associated with regional variation in pressure wave (PW) sequences, with fewer proximally and more distally; this was not observed during fasting (P < 0.001). During fasting and all rates of lipid infusion, most (87-90%) PW sequences were short (1.5-4.5 cm), with a small number (2-4%) of 10.5 cm or longer. At all times, antegrade PW sequences occurred more frequently than retrograde sequences over all distances examined (3, 4.5, and >6 cm), and the proportion of antegrade sequences increased with greater PW sequence length (P = 0.0001). Increasing ID lipid rates appeared to produce dose-related suppression of PW sequences (P < 0.001). The frequency and spatial patterning of human duodenal motor function show substantial variability in response to different nutrient delivery rates. These complex patterns are likely to be involved in duodenal modulation of flow and gastric emptying rate.
Neuroblastoma, Body Mass Index, and Survival

AbstractExtremes of body mass index (BMI) at diagnosis of childhood cancers have been associated with poorer prognosis.The aims of this retrospective review were to examine the growth and BMI status of children diagnosed with neuroblastoma (NB) and determine if BMI status at diagnosis affected survival.Between 1985 and 2005, 154 children were diagnosed with NB at Sydney Children's Hospitals Network (Westmead), Australia, of which 129 had both length/height and weight recorded in the medical records at diagnosis. BMI was calculated and children were classified as underweight (BMI <15th percentile), normal weight, and overweight (BMI >85th percentile). Disease stage was classified according to the International NB Staging System.At diagnosis, 24.0% of the children were classified as underweight and 11.6% were overweight. Six months after diagnosis all children except those with stage 4s disease had a decrease in BMI z-score; difference in estimated marginal mean −0.73, P < . 001. After 12 months an increase in BMI z-score was observed and by 2 years BMI z-score was significantly higher than BMI z-score at baseline; difference in estimated marginal mean 0.81, P = . 007. At the last follow-up (median 5.6 years [range 3–7] after diagnosis) the proportion of children who were classified as underweight decreased to 8.7% and the proportion of children who were classified as overweight increased to 27.5%. The overall survival rate was 61.2%; however, BMI status did not predict survival. In multivariable Cox regression modeling, stage at diagnosis was the only predictor of survival; children diagnosed with stage 4 were less likely to survive (hazard ratio [HR] [95%CI]: 7.02 [1.7–29.0], P = .007). Almost a quarter of children with NB were underweight at diagnosis. However, we did not demonstrate a prognostic association between BMI status and survival. The high proportion of children who were classified as overweight at follow-up indicates a need for nutritional interventions to prevent potential late effects.
A Vision-Based Learning Method for Pushing Manipulation

We describe an unsupervised on-line method for learning of manipulative actions that allows a robot to push an object connected to it with a rotational point con- tact to a desired point in image-space. By observing tile results of its actions on tile object's orientation in image- space, the system forms a predictive forward empirical model. This acquired model is used on-line for manipula- tion planning and control as it improves. Rather than ex- plicitly inverting the forward model to achieve trajectory control, a stochastic action selection technique (Moore, 1990) is used to select the most informative and promising actions, thereby integrating active perception and learn- ing by combining on-line improvement, task-directed ex- ploration, and model exploitation. Simulation and exper- imental results of the approach are presented.
The M Dwarf GJ 436 and its Neptune‐Mass Planet

We determine stellar parameters for the M dwarf GJ 436, which hosts a Neptune‐mass planet. We employ primarily spectral modeling at low and high resolution, examining the agreement between model and observed optical spectra of five comparison stars of type M0–M3. The modeling of high‐resolution optical spectra suffers from uncertainties in TiO transitions, affecting the predicted strengths of both atomic and molecular lines in M dwarfs. The determination of Teff, gravity, and metallicity from optical spectra remains at ∼10%. As molecules provide opacity both in lines and as an effective continuum, determining molecular transition parameters remains a challenge facing models such as the PHOENIX series, best verified with high resolution and spectrophotometric spectra. Our analysis of GJ 436 yields an effective temperature of Teff = 3350 ± 300 K and a mass of 0.44 M⊙. New Doppler measurements of GJ 436 with a precision of 3 m s−1 taken during 6 years improve the Keplerian model of the planet, giving it a minimum mass Msin i = 0.0713 MJup = 22.6 M⊕, period P = 2.6439 days, and eccentricity e = 0.16 ± 0.02. The noncircular orbit contrasts with the tidally circularized orbits of all close‐in exoplanets, implying either ongoing pumping of eccentricity by a more distant companion, or a higher Q value for this low‐mass planet. The velocities indeed reveal a long‐term trend, indicating a possible distant companion.
Trauma death: views of the public and trauma professionals on death and dying from injuries.

OBJECTIVES To determine the values and preferences of the general public and trauma professionals regarding end-of-life care due to injury so as to inform practice guidelines. DESIGN, SETTING, AND PARTICIPANTS Surveys of the general public sampled by random-digit dialing between June 6, 2005, and July 5, 2005, and of a convenience sample of trauma professionals during fall 2005 in the United States were conducted regarding preferences for care in the prehospital, emergency, and critical care settings. MAIN OUTCOME MEASURES Responses to the survey questions. RESULTS Most of the public and trauma professionals would prefer palliative care when doctors determine that aggressive critical care would not be beneficial in saving their lives. During resuscitation of an injured loved one, 51.9% of the public and 62.7% of the professionals would prefer to be in the emergency department treatment room. Most of the public believes that patients should have the right to demand care not recommended by their physicians. Most of both groups trust a doctor's decision to withdraw treatment when futility is determined. More of the public (57.4%) than the professionals (19.5%) believe that divine intervention could save a person when physicians believe treatment is futile. Other findings suggest further important insights. CONCLUSIONS The results pose challenges that will require societal discourse to determine the best practice. Resolutions will need to be included in educational curricula and incorporated into practice to ensure that dying trauma victims and their families receive quality end-of-life care.
Interstitial lung disease associated with gefitinib in Japanese patients with EGFR-mutated non-small-cell lung cancer: combined analysis of two Phase III trials (NEJ 002 and WJTOG 3405).

OBJECTIVE Interstitial lung disease associated with gefitinib is a critical adverse reaction. When geftinib was administered to EGFR-unknown patients, the interstitial lung disease incidence rate was approximately 3-4% in Japan, and usually occurs during the first 4 weeks of treatment. However, it has not been fully investigated in EGFR-mutated patients. METHODS We collected clinical records of participants of two Phase III trials (WJTOG 3405 and NEJ 002), which compared gefitinib with platinum doublet chemotherapy. All patients were EGFR mutated, chemo-naïve and had good performance status. RESULTS A total of 402 patients were enrolled in this study. In the gefitinib arm, 10 (5.0%) of 201 patients developed interstitial lung disease, of whom five (2.5%) were Grade 3 or greater, with two deaths (1.0%). In contrast, only one patient developed interstitial lung disease (Grade 1) in the chemotherapy arm. With regard to gefitinib, smoking history was significantly associated with developing interstitial lung disease (odds ratio 0.18; 95% confidence interval: 0.05-0.74; P = 0.01). The cumulative incidence rate of interstitial lung disease was similar in the 0-4, 5-8 and 9-12 week time periods. However, between smokers and never-smokers, cumulative incidence rates in the first 4 weeks were significantly different (4.7% versus 0%, P = 0.03). Three of 10 patients developed interstitial lung disease after 8 weeks of gefitinib administration (days 135, 171 and 190, respectively). CONCLUSIONS Among EGFR-mutated patients, the incidence of interstitial lung disease associated with gefitinib was not different from that in previous reports. Smoking history was associated with developing interstitial lung disease, and smokers had a higher incidence rate of interstitial lung disease in the first 4 weeks.