Miracle-dz/UniFAR-FTUs huggingface dataset:
Accretion disc variability in the hard state of black hole X-ray binaries

XMM–Newton X-ray spectra of the hard state black hole X-ray binaries (BHXRBs) SWIFT J1753.5? 0127 and GX 339? 4 show evidence for accretion disc blackbody emission, in addition to hard power laws. The soft and hard band power spectral densities (PSDs) of these sources demonstrate variability over a wide range of time-scales. However, on time-scales of tens of seconds, corresponding to the putative low-frequency Lorentzian in the PSD, there is additional power in the soft band. To interpret this behaviour, we introduce a new spectral analysis technique, the 'covariance spectrum', to disentangle the contribution of the X-ray spectral components to variations on different time-scales. We use this technique to show that the disc blackbody component varies on all time-scales, but varies more, relative to the power law, on longer time-scales. This behaviour explains the additional long-term variability seen in the soft band. Comparison of the blackbody and iron line normalizations seen in the covariance spectra in GX 339? 4 implies that the short-term blackbody variations are driven by thermal reprocessing of the power-law continuum absorbed by the disc. However, since the amplitude of variable reflection is the same on long and short time-scales, we rule out reprocessing as the cause of the enhanced disc variability on long time-scales. Therefore, we conclude that the long time-scale blackbody variations are caused by instabilities in the disc itself, in contrast to the stable discs seen in BHXRB soft states. Our results provide the first observational evidence that the low-frequency Lorentzian feature present in the PSD is produced by the accretion disc.
UVR, Vitamin D and Three Autoimmune Diseases—Multiple Sclerosis, Type 1 Diabetes, Rheumatoid Arthritis

Abstract We review the evidence indicating a possible beneficial role for UVR on three Th1-mediated autoimmune diseases: multiple sclerosis, type 1 diabetes and rheumatoid arthritis in relation to recent developments in photoimmunology. Recent work suggests that UVR exposure may be one factor that can attenuate the autoimmune activity leading to these three diseases through several pathways involving UVB and UVA irradiation, UVR-derived vitamin D synthesis and other routes such as α-melanocyte-stimulating hormone, calcitonin gene related peptide and melatonin. Ecological features, particularly a gradient of increasing prevalence of multiple sclerosis and type 1 diabetes with higher latitude, provide some support for a beneficial role of UVR. Analytical studies provide additional support, particularly as low vitamin D has been prospectively associated with disease onset for all three diseases, but are not definitive. Randomized controlled trial data are required. Further, we discuss how associated genetic studies may assist the accumulation of evidence with regard to the possible causal role of low UVR exposure and/or low vitamin D status in the development of these diseases.
Steady multipolar planar vortices with nonlinear critical layers

This article considers a family of steady multipolar planar vortices, which are the superposition of an axisymmetric mean flow, and an azimuthal disturbance in the context of inviscid, incompressible flow. This configuration leads to strongly nonlinear critical layers where the angular velocities of the mean flow and the disturbance are comparable. The poles located on the same critical radius possess the same uniform vorticity, whose weak amplitude is of the same order as the azimuthal disturbance. This problem is examined through aperturbation expansion in which relevant nonlinear terms are retained in the critical layer equations, while viscosity is neglected. In particular, the associated singularity at the meeting point of the separatrices is treated by employing appropriate re-scaled variables. Matched asymptotic expansions are then used to obtain a complete analytical description of these vortices.
Evaluating the Feasibility of an Agglomerative Hierarchy Clustering Algorithm for the Automatic Detection of the Arterial Input Function Using DSC-MRI

During dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI), it has been demonstrated that the arterial input function (AIF) can be obtained using fuzzy c-means (FCM) and k-means clustering methods. However, due to the dependence on the initial centers of clusters, both clustering methods have poor reproducibility between the calculation and recalculation steps. To address this problem, the present study developed an alternative clustering technique based on the agglomerative hierarchy (AH) method for AIF determination. The performance of AH method was evaluated using simulated data and clinical data based on comparisons with the two previously demonstrated clustering-based methods in terms of the detection accuracy, calculation reproducibility, and computational complexity. The statistical analysis demonstrated that, at the cost of a significantly longer execution time, AH method obtained AIFs more in line with the expected AIF, and it was perfectly reproducible at different time points. In our opinion, the disadvantage of AH method in terms of the execution time can be alleviated by introducing a professional high-performance workstation. The findings of this study support the feasibility of using AH clustering method for detecting the AIF automatically.
Evaluation of Early versus Delayed Laparoscopic Cholecystectomy in Acute Cholecystitis

Background. The role of early laparoscopic cholecystectomy for acute cholecystitis with cholelithiasis is not yet established. The aim of our prospective randomized study was to evaluate the safety and feasibility of early LC for acute cholecystitis and to compare the results with delayed LC. Methods. Between March 2007 to December 2008, 50 patients with diagnosis of acute cholecystitis were assigned randomly to early group, n = 25 (LC within 24 hrs of admission), and delayed group, n = 25 (initial conservative treatment followed by delayed LC, 6–8 weeks later). Results. We found in our study that the conversion rate in early LC and delayed LC was 16% and 8%, respectively, Operation time for early LC was 69.4 min versus 66.4 min for delayed LC, postoperative complications for early LC were 24% versus 8% for delayed LC, and blood loss was 159.6 mL early group versus 146.8 mL for delayed group. However early LC had significantly shorter hospital stay (4.1 days versus 8.6 days). Conclusions. Early LC for acute cholecystitis with cholelithiasis is safe and feasible, offering the additional benefit of shorter hospital stay. It should be offered to the patients with acute cholecystitis, provided that the surgery is performed within 96 hrs of acute symptoms by an experienced surgeon.
Improving skin lesion segmentation in dermoscopic images by thin artefacts removal methods

In dermoscopic images, various thin artefacts naturally appear, most usually in the form of hairs. While trying to find the border of the skin lesion, these artefacts effect the lesion segmentation methods and also the subsequent classification. Currently, there is a lot of research focus in this area and various methods are presented both for skin lesion segmentation and thin artefacts removal. In this paper, we investigate into three different thin artefacts removal methods and compare their results using two different skin lesion segmentation methods. The segmentation results are compared with ground truth segmentation. In addition, we introduce our novel artefacts removal method, which combined with the Expectation Maximization image segmentation outperforms all the tested methods.
Situational judgement tests for selection

When situational judgement tests (SJTs) began to regain popularity among the scientific community in the 1990s, there was an implicit notion that they captured contextdependent knowledge. In fact, the term ‘situational judgement’ carries the connotation of test‐takers’ responses being more effective when they consider the specifics of the situation. In recent years another perspective has emerged, which views SJTs as capturing relatively context‐independent knowledge (or general domain knowledge; Motowidlo, Crook, Kell & Naemi, 2009; Motowidlo, Hooper & Jackson, 2006a). Although SJTs and their items will often fall somewhere between these two perspectives, we posit in this chapter that it might be useful to distinguish between them. So far, there has been no review of the SJT literature in terms of these two approaches. This is understandable, as over the years the two perspectives have emerged alongside each other. Therefore, the aim of this chapter is to review SJT research according to these two approaches.
Individualized medicine 2010

• Molecular analyses • Mutations – polymorphisms – HapMap ‐ Mutations ‐ Mutations and diseases ‐ Polymorphisms ‐ Polymorphisms and diseases or disease predispositions ‐ HapMap project • Signature analyses – omics ‐ Lymphoma ‐ Breast cancer ‐ Lung cancer ‐ Prostate cancer ‐ Hepatocellular carcinoma ‐ Cholangiocellular carcinoma ‐ Non‐malignant diseases ‐ Conclusions and perspectives
PROGRESSION THROUGH THE RANKS: THE INFLUENCE OF COPING STRATEGIES AND CANDIDATE REACTIONS ON PROMOTIONAL EXAM PERFORMANCE AND ORGANIZATIONAL PERCEPTIONS

This study examined candidate reactions (motivation, performance anxiety, behavioural anxiety, procedural justice, & interactional justice) to promotional exams in a sample of police officers. Reactions were found to be significantly and differentially related to exam performance, organizational respect and recommendation intentions. Reactions also mediated relations between candidate coping strategies and exam performance. Implications of these findings and recommendations for future research are discussed.
An Amplitude Modulation/Demodulation Scheme for Whisker-Based Texture Perception

Whisking rodents can discriminate finely textured objects using their vibrissae. The biomechanical and neural processes underlying such sensory tasks remain elusive. Here we combine the use of model micropatterned substrates and high-resolution videography of rats' whiskers during tactile exploration to study how texture information is mechanically encoded in the whisker motion. A biomechanical modeling of the whisker is developed, which yields quantitative predictions of the spectral and temporal characteristics of the observed whisker kinetics, for any given topography. These texture-induced whisker vibrations are then replayed via a multiwhisker stimulator while recording neuronal responses in the barrel field of the primary somatosensory cortex (S1bf). These results provide a comprehensive description of the transduction process at play during fine texture sensing in rats. They suggest that the sensory system operates through a vibratory amplitude modulation/demodulation scheme. Fine textural properties are encoded in the time-varying envelope of the whisker-resonant vibrations. This quantity is then recovered by neural demodulation, as it effectively drives the spiking-rate signal of a large fraction of S1 cortical neurons. This encoding/decoding scheme is shown to be robust against variations in exploratory conditions, such as the scanning speed or pad-to-substrate distance, thus allowing for reliable tactile discrimination in realistic conditions.
The Impact of Marketing-Induced versus Word-of-Mouth Customer Acquisition on Customer Equity Growth

Companies can acquire customers through costly but fast-acting marketing investments or through slower but cheaper word-of-mouth processes. Their long-term success depends critically on the contribution of each acquired customer to overall customer equity. The authors propose and test an empirical model that captures these long-term effects. An application to a Web hosting company reveals that marketing-induced customers add more short-term value, but word-of-mouth customers add nearly twice as much long-term value to the firm. The authors illustrate their findings with some dynamic simulations of the long-term impact of different resource allocations for acquisition marketing.
Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL Alcohol

Background. The dose of alcohol used in EUS-CPN is not standardized. The objective was to compare the safety of 20 mL alcohol versus 10 mL alcohol during EUS-CPN for patients with pancreatic cancer-related pain. Methods. 20 patients were selected to receive 10 mL or 20 mL of alcohol during EUS-CPN. Followup was done at baseline, 24 hours, and weekly. Health-related quality of life (HRQoL) was assessed at baseline, week 2, week 4, and every 4 weeks thereafter until pain returned. Results. There were no major complications in both groups. Minor self-limited adverse effects were seen in 6 (30%) subjects and included lightheadedness in 1 (5%), transient diarrhea in 2 (10%), and transient nausea and vomiting in 3. Pain relief was similar in both groups: 80% in the 10 mL group and 100% in the 20 mL group (P = 0.21). The mean (± SD) duration of pain relief in the 10 mL and 20 mL groups was 7.9 ± 10.8 and 8.4 ± 9.2 weeks, respectively. 30% of patients in each group had complete pain relief. Conclusions. EUS-CPN using 20 mL of alcohol is safe. Similar clinical outcomes were seen in both groups. Further investigations to confirm these findings are warranted.
A perfect umma? How ethnicity shapes the organization and operation of Dagestan's jihadist groups

Drawing on unique interviews with former jihadists from Russia's autonomous republic of Dagestan, this article is the first to examine the impact of ethnicity on jihadist groups' methods of organization and operations, primarily in terms of their target selection, local support, and recruitment and leadership policies. It distinguishes between largely monoethnic rural jamaats—or jihadist groups—and multiethnic urban jamaats, pointing to the contested nature of ethnicity, particularly in the latter group. It examines the steps taken by the leadership of urban jamaats to overcome ethnic cleavages and avoid interethnic tension both within the jihadists' ranks and with regard to the local population. The article illustrates that, as a divisive phenomenon in multiethnic urban jamaats, ethnic identity has been deliberately downplayed by the leadership of these groups at the expense of strengthening supra-ethnic Salafi-jihadist identity. The article also highlights the significance of ethnic identity in jihadist groups, in spite of it being contradictory to Salafi-jihadist doctrine.
Diameter of Cayley graphs of permutation groups generated by transposition trees

Let $\Gamma$ be a Cayley graph of the permutation group generated by a transposition tree $T$ on $n$ vertices. In an oft-cited paper \cite{Akers:Krishnamurthy:1989} (see also \cite{Hahn:Sabidussi:1997}), it is shown that the diameter of the Cayley graph $\Gamma$ is bounded as $$\diam(\Gamma) \le \max_{\pi \in S_n}{c(\pi)-n+\sum_{i=1}^n \dist_T(i,\pi(i))},$$ where the maximization is over all permutations $\pi$, $c(\pi)$ denotes the number of cycles in $\pi$, and $\dist_T$ is the distance function in $T$. In this work, we first assess the performance (the sharpness and strictness) of this upper bound. We show that the upper bound is sharp for all trees of maximum diameter and also for all trees of minimum diameter, and we exhibit some families of trees for which the bound is strict. We then show that for every $n$, there exists a tree on $n$ vertices, such that the difference between the upper bound and the true diameter value is at least $n-4$. Observe that evaluating this upper bound requires on the order of $n! $ (times a polynomial) computations. We provide an algorithm that obtains an estimate of the diameter, but which requires only on the order of (polynomial in) $n$ computations; furthermore, the value obtained by our algorithm is less than or equal to the previously known diameter upper bound. This result is possible because our algorithm works directly with the transposition tree on $n$ vertices and does not require examining any of the permutations (only the proof requires examining the permutations). For all families of trees examined so far, the value $\beta$ computed by our algorithm happens to also be an upper bound on the diameter, i.e. $$\diam(\Gamma) \le \beta \le \max_{\pi \in S_n}{c(\pi)-n+\sum_{i=1}^n \dist_T(i,\pi(i))}. $$
A Bovine Cell Line That Can Be Infected by Natural Sheep Scrapie Prions

Cell culture systems represent a crucial part in basic prion research; yet, cell lines that are susceptible to prions, especially to field isolated prions that were not adapted to rodents, are very rare. The purpose of this study was to identify and characterize a cell line that was susceptible to ruminant-derived prions and to establish a stable prion infection within it. Based on species and tissue of origin as well as PrP expression rate, we pre-selected a total of 33 cell lines that were then challenged with natural and with mouse propagated BSE or scrapie inocula. Here, we report the successful infection of a non-transgenic bovine cell line, a sub-line of the bovine kidney cell line MDBK, with natural sheep scrapie prions. This cell line retained the scrapie infection for more than 200 passages. Selective cloning resulted in cell populations with increased accumulation of PrPres, although this treatment was not mandatory for retaining the infection. The infection remained stable, even under suboptimal culture conditions. The resulting infectivity of the cells was confirmed by mouse bioassay (Tgbov mice, Tgshp mice). We believe that PES cells used together with other prion permissive cell lines will prove a valuable tool for ongoing efforts to understand and defeat prions and prion diseases.
Gender Differences in Social Skills, Peer Relationships, and Emotional Correlates in Adults with High Functioning Autism Spectrum Disorders

ii Dedication . iv Acknowledgments. v Vita . vi List of Tables . ix List of Figures . x Chapter 1: Introduction . 1 Chapter 2: Method . 46 Chapter 3: Results . 61 Chapter 4: Discussion . 72 References . 89 Appendix A: Tables and Figures . 104 Appendix B: Questionnaires.121 Appendix C: Consent Forms . 131
Statistical Literacy : Thinking Critically about Statistics Page 0 Statistical literacy : Thinking critically about statistics As published in the Inaugural issue of the Journal “ Of Significance ” Produced by the Association of Public Data Users www . apdu

Statistical literacy is the ability to read and interpret data: the ability to use statistics as evidence in arguments. Statistical literacy is a competency: the ability to think critically about statistics. This introduction defines statistical literacy as a science of method, compares statistical literacy with traditional statistics and reviews some of the elements in reading and interpreting statistics. It gives more emphasis to observational studies than to experiments and thus to using associations to support claims about causation.
Evaluation of Environmental Safety Concentrations of DMSA Coated Fe2O3-NPs Using Different Assay Systems in Nematode Caenorhabditis elegans

Dimercaptosuccinic acid (DMSA) coating improves the uptake efficiency presumably by engendering the Fe2O3-NPs. In the present study, we investigated the possible environmental safety concentrations of Fe2O3-NPs using different assay systems in nematode Caenorhabditis elegans with lethality, development, reproduction, locomotion behavior, pharyngeal pumping, defecation, intestinal autofluorescence and reactive oxygen species (ROS) production as the endpoints. After exposure from L4-larvae for 24-hr, DMSA coated Fe2O3-NPs at concentrations more than 50 mg/L exhibited adverse effects on nematodes. After exposure from L1-larvae to adult, DMSA coated Fe2O3-NPs at concentrations more than 500 μg/L had adverse effects on nematodes. After exposure from L1-larvae to day-8 adult, DMSA coated Fe2O3-NPs at concentrations more than 100 μg/L resulted in the adverse effects on nematodes. Accompanied with the alterations of locomotion behaviors, ROS production was pronouncedly induced by exposure to DMSA coated Fe2O3-NPs in the examined three assay systems, and the close associations of ROS production with lethality, growth, reproduction, locomotion behavior, pharyngeal pumping, defecation, or intestinal autofluorescence in nematodes exposed to DMSA coated Fe2O3-NPs were confirmed by the linear regression analysis. Moreover, mutations of sod-2 and sod-3 genes, encoding Mn-SODs, showed more susceptible properties than wild-type when they were used for assessing the DMSA coated Fe2O3-NPs-induced toxicity, and the safety concentrations for DMSA coated Fe2O3-NPs should be defined as concentrations lower than 10 μg/L in sod-2 and sod-3 mutant nematodes.
The growth in gambling activity is not just in the US. In recent years 82% of Canadians participated in some form of legalized gambling (Korn and Shaffer 1999), and the hottest destination for new casinos is the island of Macau

Gambling is America‟s favorite pastime by volume. The total amount won from gamblers in the United States in 2006 was over $57 billion. To put that number in perspective, the total sales for movie tickets and music recordings was around $20 billion, and the combined sales of McDonald‟s, Burger King, Wendy‟s and Starbucks was about $28 billion in 2006. Furthermore, revenues from gambling are growing at an average of 10% each year as shown in the bottom row of Table 1.
Diet and sex hormones in girls: findings from a randomized controlled clinical trial.

BACKGROUND Results of several studies have suggested that diet during adolescence may influence the risk of breast cancer in adulthood. We evaluated whether an intervention to lower fat intake among adolescent girls altered their serum concentrations of sex hormones that, in adults, are related to breast cancer development. METHODS We conducted an ancillary hormone study among 286 of the 301 girls who participated between 1988 and 1997 in the Dietary Intervention Study in Children, in which healthy, prepubertal, 8- to 10-year-olds with elevated low-density lipoprotein cholesterol were randomly assigned to usual care or to a behavioral intervention that promoted a low-fat diet. Median time on the intervention was 7 years. Blood samples collected before randomization and at the year 1, year 3, year 5, and last visits were assayed to determine the girls' serum levels of sex hormones. All P values are two-sided. RESULTS At the year 5 visit, girls in the intervention group had 29.8% (95% confidence interval [CI] = 5.4% to 47.9%; P =.02) lower estradiol, 30.2% (95% CI = 7.0% to 47.7%; P =.02) lower non-sex hormone binding globulin-bound estradiol, 20.7% (95% CI = 4.7% to 34.0%; P =.02) lower estrone, and 28.7% (95% CI = 5.1% to 46.5%; P =.02) lower estrone sulfate levels during the follicular phase of the menstrual cycle and 27.2% (95% CI = 5.7% to 53.1%; P =.01) higher testosterone levels during the luteal phase of the menstrual cycle than did girls in the usual care group. At the last visit, the luteal phase progesterone level was 52.9% (95% CI = 20.0% to 72.3%) lower for girls in the intervention group than for girls in the usual care group (P =.007). CONCLUSION Modest reductions in fat intake during puberty are associated with changes in sex hormone concentrations that are consistent with alterations in the function of the hypothalamic-pituitary-ovarian axis. Whether these changes influence breast cancer risk is currently unknown.