Miracle-dz/UniFAR-FTUs huggingface dataset:
Information Embedding on Actions

The problem of optimal actuation for channel and source coding was recently formulated and solved in a number of relevant scenarios. In this class of models, actions are taken at encoders or decoders, either to acquire side information in an efficient way or to control or probe effectively the channel state. In this paper, the problem of embedding information on the actions is studied for both the source and the channel coding setups. In both cases, a decoder is present that observes only a function of the actions taken by an encoder or a decoder of an action-dependent point-to-point link. For the source coding model, this decoder wishes to reconstruct a lossy version of the source being transmitted over the point-to-point link, while for the channel coding problem, the decoder wishes to retrieve a portion of the message conveyed over the link. For the problem of source coding with actions taken at the decoder, a single letter characterization of the set of all achievable tuples of rate, distortions at the two decoders, and action cost is derived, under the assumption that the mentioned decoder observes a function of the actions noncausally, strictly causally or causally. A special case of the problem in which the actions are taken by the encoder is also solved. A single-letter characterization of the achievable capacity-cost region is then obtained for the channel coding setup with actions. Examples are provided that shed light into the effect of information embedding on the actions for the action-dependent source and channel coding problems.
FBS-Radar: Uncovering Fake Base Stations at Scale in the Wild

Base stations constitute the basic infrastructure of today’s cellular networks. Unfortunately, vulnerabilities in the GSM (2G) network protocol enable the creation of fake base stations (FBSes) that are not authorized by network operators. Criminal gangs are using FBSes to directly attack users by sending spam and fraud SMS messages, even if the users have access to 3G/4G networks. In this paper, we present the design, deployment, and evolution of an FBS detection system called FBS-Radar, based on crowdsourced data of nearly 100M users. In particular, we evaluate five different metrics for identifying FBSes in the wild, and find that FBSes can be precisely identified without sacrificing user privacy. Additionally, we present a novel method for accurately geolocating FBSes while incurring negligible impact on end-user devices. Our system protects users from millions of spam and fraud SMS messages per day, and has helped the authorities arrest hundreds of FBS operators.
The Conformational Transition Pathways of ATP-Binding Cassette Transporter BtuCD Revealed by Targeted Molecular Dynamics Simulation

BtuCD is a member of the ATP-binding cassette transporters in Escherichia coli that imports vitamin B12 into the cell by utilizing the energy of ATP hydrolysis. Crystal structures of BtuCD and its homologous protein HI1470/1 in various conformational states support the “alternating access” mechanism which proposes the conformational transitions of the substrate translocation pathway at transmembrane domain (TMD) between the outward-facing and inward-facing states. The conformational transition at TMD is assumed to couple with the movement of the cytoplasmic nucleotide-binding domains (NBDs) driven by ATP hydrolysis/binding. In this study, we performed targeted molecular dynamics (MD) simulations to explore the atomic details of the conformational transitions of BtuCD importer. The outward-facing to inward-facing (O→I) transition was found to be initiated by the conformational movement of NBDs. The subsequent reorientation of the substrate translocation pathway at TMD began with the closing of the periplasmic gate, followed by the opening of the cytoplamic gate in the last stage of the conformational transition due to the extensive hydrophobic interactions at this region, consistent with the functional requirement of unidirectional transport of the substrates. The reverse inward-facing to outward-facing (I→O) transition was found to exhibit intrinsic diversity of the conformational transition pathways and significant structural asymmetry, suggesting that the asymmetric crystal structure of BtuCD-F is an intermediate state in this process.
A Technique for the Microscopic Study of Blood Vessels in Living Striated Muscle (Cremaster)

A technique is described whereby it is possible to study the vessels of a striated muscle (the rat cremaster) in vivo. In the anesthetized rat, a part of the scrotal skin is excised; the cremaster muscle is exposed and studied by epi-illumination. To improve the optical conditions, a white reflecting surface is brought behind the cremaster through the inguinal canal. Twitching of the muscle may be prevented by the use of a neuromuscular blocking agent. It is also possible to study the blood vessels of the fascia overlying the cremaster. The method may also be applied to the rabbit; it is recommended for short-term studies in which topographic requirements prevail. Its advantages and limitations are discussed.
Agreement between veterinary students and anesthesiologists regarding postoperative pain assessment in dogs.

OBJECTIVE To determine the levels of agreement among first- and second-year veterinary students and experienced anesthesiologists in assessing postoperative pain in dogs from video-recordings. STUDY DESIGN Cross-sectional study. SUBJECTS Twenty-seven veterinary students, five anesthesiologists and 13 canine clinical patients. METHODS Prior to their enrolment in a core anesthesia course, veterinary students volunteered to watch 13 90 second videos of dogs. Dogs were hospitalized in an intensive care unit after a variety of surgical procedures. Students were asked to score the level of the dogs' pain using the Dynamic Interactive Visual Analog Scale and the Short Form of the Glasgow Composite-Measure Pain Scale. The same videotapes were scored by five board-certified anesthesiologists. The differences and agreement between the ratings of anesthesiologists and students, and first- and second-year students were determined with Mann-Whitney U-tests and Fleiss' or Cohen's kappa, respectively. RESULTS Pain scores assigned by students and anesthesiologists differed significantly (p < 0.01). Students assigned higher pain scores to dogs that were given low pain scores by anesthesiologists, and lower pain scores to dogs deemed to be in more pain by anesthesiologists. On average, students assigned higher scores on both scales. CONCLUSIONS AND CLINICAL RELEVANCE Veterinary students early in their training assigned pain scores to dogs that differed from scores assigned by experienced anesthesiologists.
MAPK1 of Leishmania donovani Modulates Antimony Susceptibility by Downregulating P-Glycoprotein Efflux Pumps

ABSTRACT Emergence of resistance to pentavalent antimonials has become a severe obstacle in the treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Mitogen-activated protein kinases (MAPKs) are well-known mediators of signal transduction of eukaryotes, regulating important processes, like proliferation, differentiation, stress response, and apoptosis. In Leishmania, MAPK1 has been shown to be consistently downregulated in antimony-resistant field isolates, suggesting that it has a role in antimony resistance. The present work investigates the molecular mechanism of MAPK1 in antimony resistance in Leishmania donovani. The L. donovani MAPK1 (LdMAPK1) single-allele replacement mutants exhibited increased resistance to Sb(III) (5.57-fold) compared to wild-type promastigotes, while overexpressing parasites became much more susceptible to antimony. The LdMAPK1-mediated drug sensitivity was directly related to antimony-induced apoptotic death of the parasite, as was evidenced by a 4- to 5-fold decrease in cell death parameters in deletion mutants and a 2- to 3-fold increase in MAPK1-overexpressing cells. LdMAPK1-underexpressing parasites also exhibited increased P-glycoprotein (P-gp)-mediated efflux pump activity, while a significant decrease in pump activity was observed in overexpressing cells. This change in efflux pump activity was directly related to expression levels of P-gp in all cell lines. However, episomal complementation of the gene restored normal growth, drug sensitivity, P-gp expression, and efflux pump activity. The data indicate that LdMAPK1 negatively regulates the expression of P-glycoprotein-type efflux pumps in the parasite. The decrease in efflux pump activity with an increase in LdMAPK1 expression may result in increased antimony accumulation in the parasite, making it more vulnerable to the drug.
Ecological IVIS design: using EID to develop a novel in-vehicle information system

New in-vehicle information systems (IVIS) are emerging which purport to encourage more environment friendly or ‘green’ driving. Meanwhile, wider concerns about road safety and in-car distractions remain. The ‘Foot-LITE’ project is an effort to balance these issues, aimed at achieving safer and greener driving through real-time driving information, presented via an in-vehicle interface which facilitates the desired behaviours while avoiding negative consequences. One way of achieving this is to use ecological interface design (EID) techniques. This article presents part of the formative human-centred design process for developing the in-car display through a series of rapid prototyping studies comparing EID against conventional interface design principles. We focus primarily on the visual display, although some development of an ecological auditory display is also presented. The results of feedback from potential users as well as subject matter experts are discussed with respect to implications for future interface design in this field.
Influence of image interactivity on approach responses towards an online retailer

Image interactivity allows the customer to create and manipulate visual images of a product on a Web site. We measured the effect of exposure to an image interactivity function from an apparel retailer’s Web site on approach responses towards the retailer. The image interactivity function from the Web site allowed participants to mix and match apparel product images to help determine how well they coordinated. Dependent variables used to tap approach responses were attitude towards the online store, willingness to purchase from the online store, willingness to return to the online store, probability of spending more time than planned shopping on the site, and likelihood of patronizing the online retailer’s bricks‐and‐mortar store. We employed a repeated‐measures experimental design with 103 subjects. Paired t‐tests provided empirical support for the effect of image interactivity on enhancing approach responses towards the retailer. However, differences in approach responses existed between males and femal.
Biochemical Responses to Level-1 Yo-Yo Intermittent Recovery Test in Young Tunisian Football Players

Purpose The aim of this work was to investigate the metabolic and muscle damage responses after the level-1 Yo-Yo intermittent recovery test (YYIRT) in young football players. Methods Fifteen male football players (17.42 ± 0.2 yrs, 69.91 ± 4.4 kg, 178.64 ± 3.8 cm; mean ± SD) participated in this study. Fasting blood samples for various biochemical parameters (i.e. lactate (Lac), glucose (GLC), triglycerides (Tri), creatine kinase (CK), uric acid (UA)) collected from a forearm vein after 5-min of seated rest and 3-min after the test. Moreover, rating of perceived exertion (RPE) and maximal heart rate during and after the YYIRT were recorded. Results Mean levels of the selected biochemical markers were raised after the YYIRT exercise (P<0.001 for the other markers). Moreover, lipid parameters increased significantly after the test (P<0.01 for Tri and P<0.001 for HDL). Conclusion These findings confirm the higher metabolic demand of aerobic as well as anaerobic metabolism and reflect a significant mobilization of purine cycle during the YYIRT. The increase of muscle damage markers also reflects the higher anaerobic solicitation. From these findings, we can conclude the importance of aerobic and anaerobic metabolism during soccer-specific endurance performance (i.e. YYIRT, soccer match).
Differences in temporal order memory among young, middle-aged, and older adults may depend on the level of interference

Age-related changes in temporal order memory have been well documented in older adults; however, little is known about this ability during middle age. We tested healthy young, middle-aged, and older adults on a previously published visuospatial temporal order memory test involving high and low interference conditions. When interference was low, young and middle-aged adults did not differ, but both groups significantly outperformed older adults. However, when interference was high, significant differences were found among all three age groups. The data provide evidence that temporal order memory may begin to decline in middle age, particularly when temporal interference is high.
Analysis of the concept of mutuality.

PURPOSE Mutuality is explored as an interaction style for providers and clients that encourages accountability. SIGNIFICANCE Accountability by both providers and clients is necessary to manage health care costs and outcomes. ORGANIZING FRAMEWORK Walker and Avant's method of concept analysis. SCOPE Literature from 1930 to 1996. Mutuality is compared to autonomy, reciprocity, consumerism, negotiation, participation, collaboration, and paternalism. CONCLUSIONS Mutuality is shown to balance power and respect, and to promote productive provider-client communication. This interaction style for partnership relationships fosters positive and lasting health care outcomes. IMPLICATIONS Nurses are challenged to develop the skill of eliciting give and take, and creative, mutual exchanges.
Context-dependent predictions and cognitive arm control with XCSF

While John Holland has always envisioned learning classifier systems (LCSs) as cognitive systems, most work on LCSs has focused on classification, datamining, and function approximation. In this paper, we show that the XCSF classifier system can be very suitably modified to control a robot system with redundant degrees of freedom, such as a robot arm. Inspired by recent research insights that suggest that sensorimotor codes are nearly ubiquitous in the brain and an essential ingredient for cognition in general, the XCSF system is modified to learn classifiers that encode piecewise linear sensorimotor structures, which are conditioned on prediction-relevant contextual input. In the investigated robot arm problem, we show that XCSF partitions the (contextual) posture space of the arm in such a way that accurate hand movements can be predicted given particular motor commands. Furthermore, we show that the inversion of the sensorimotor predictive structures enables accurate goal-directed closed-loop control of arm reaching movements. Besides the robot arm application, we also investigate performance of the modified XCSF system on a set of artificial functions. All results point out that XCSF is a useful tool to evolve problem space partitions that are maximally effective for the encoding of sensorimotor dependencies. A final discussion elaborates on the relation of the taken approach to actual brain structures and cognitive psychology theories of learning and behavior.
Structural and microstructural analysis of K–Mg salt layers in the Zechstein 3 of the Veendam Pillow, NE Netherlands: development of a tectonic mélange during salt flow

Abstract In fully developed evaporite cycles, effective viscosity contrasts of up to five orders of magnitude are possible between different layers, but the structures and mechanics in evaporites with such extreme mechanical stratification are not well understood. The Zechstein 3 unit in the Veendam salt pillow in the Netherlands contains anhydrite, halite, carnallite and bischofite, showing this extreme mechanical stratification. The Veendam Pillow has a complex multiphase salt tectonic history as shown by seismic reflection data: salt withdrawal followed by convergent flow into the salt pillow produced ruptures and folds in the underlying Z3-anhydrite–carbonate stringer and deformed the soft Z3-1b layer We analysed a unique carnallite- and bischofite-rich drill core from the soft Z3-1b layer by macroscale photography, bulk chemical methods, X-ray diffraction and optical microscopy. Results show high strain in the weaker bischofite- and carnallite-rich layers, with associated dynamic recrystallisation at very low differential stress, completely overprinting the original texture. Stronger layers formed by alternating beds of halite and carnallite show complex recumbent folding on different scales commonly interrupted by sub-horizontal shear zones with brittle deformation, veins and boudinage. We attribute this tectonic fragmentation to be associated with a softening of the complete Z3-1b subunit during its deformation. The result is a tectonic mélange with cm- to 10 m-size blocks with frequent folds and boudinage. We infer that these structures and processes are common in deformed, rheologically strongly stratified evaporites.
Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids

Background: Anti-citrullinated protein antibodies (ACPA) are specifically and frequently detected in sera of patients with rheumatoid arthritis (RA). Citrullinated fibrin or fibrinogen is a candidate autoantigen of such antibodies. Objective: To investigate the presence of citrullinated fibrinogen (cFBG) in the plasma or synovial fluid of patients with RA and control patients, and to determine cFBG levels and their relationship with serum markers for RA if it is present. Methods: A sandwich enzyme linked immunosorbent assay (ELISA) to measure cFBG was established using monoclonal antibodies cF16.1 and cF252.1, generated by immunising mice with R16Cit and R252Cit, the fibrinogen Aα chain derived sequences with citrulline at position 16 and 252, respectively, and the presence of cFBG was further investigated with immunoprecipitation-western blotting. Results: Positive signals were detected in 11/15 RA synovial fluids (RASFs), but not in osteoarthritis synovial fluids or RA plasma with sandwich ELISA for cFBG using cF16.1 and an anti-modified citrulline (AMC) antibody. The presence of cFBG in RASFs was confirmed by immunoprecipitation-western blotting. Furthermore, most RA sera strongly reacted against R16Cit. No relationship was seen between RASF cFBG levels and C reactive protein or anti-cyclic citrullinated peptide antibody levels of the paired sera. Conclusion: cFBG is detected as a soluble citrullinated autoantigen in RASFs and may therefore be a genuine candidate antigen for ACPA in patients with RA.
Observations of Nonlinear Internal Wave Run-Up to the Surfzone

AbstractThe cross-shore evolution of nonlinear internal waves (NLIWs) from 8-m depth to shore was observed by a dense thermistor array and ADCP. Isotherm oscillations spanned much of the water column at a variety of periods. At times, NLIWs propagated into the surfzone, decreasing temperature by ≈1°C in 5 min. When stratification was strong, temperature variability was strong and coherent from 18- to 6-m depth at semidiurnal and harmonic periods. When stratification weakened, temperature variability decreased and was incoherent between 18- and 6-m depth at all frequencies. At 8-m depth, onshore coherently propagating NLIW events had associated rapid temperature drops (ΔT) up to 1.7°C, front velocity between 1.4 and 7.4 cm s−1, and incidence angles between −5° and 23°. Front position, ΔT, and two-layer equivalent height zIW of four events were tracked upslope until propagation terminated. Front position was quadratic in time, and normalized ΔT and zIW both decreased, collapsing as a linearly decaying funct.
International Journal of Behavioral Development Attachment Working Models as Unconscious Structures: an Experimental Test Attachment Working Models as Unconscious Structures: an Experimental Test

Internal working models of attachment (IWMs) are presumed to be largely unconscious representations of childhood attachment experiences. Several instruments have been developed to assess IWMs; some of them are based on self-report and others on narrative interview techniques. This study investigated the capacity of a self-report measure, the Inventory of Parent and Peer to measure unconscious attachment models. We compared scores on the two attachment instruments to response latencies in an attachment priming task. It was shown that attachment organisation assessed by the AAI correlates with priming effects, whereas the IPPA scales were inversely or not related to priming. The results are interpreted as support for the assumption that the AAI assesses, to a certain degree, unconscious working models of attachment.
Adhesion of microbes using 3‐aminopropyl triethoxy silane and specimen stabilisation techniques for analytical transmission electron microscopy

A variety of adhesive support‐films were tested for their ability to adhere various biological specimens for transmission electron microscopy. Support films primed with 3‐amino‐propyl triethoxy silane (APTES), poly‐l‐lysine, carbon and ultraviolet‐B (UV‐B)‐irradiated carbon were tested for their ability to adhere a variety of biological specimens including axenic cultures of Bacillus subtilis and Escherichia coli and wild‐type magnetotactic bacteria. The effects of UV‐B irradiation on the support film in the presence of air and electrostatic charge on primer deposition were tested and the stability of adhered specimens on various surfaces was also compared. APTES‐primed UV‐B‐irradiated PioloformTM was consistently the best adhesive, especially for large cells, and when adhered specimens were UV‐B irradiated they became remarkably stable under an electron beam. This assisted the acquisition of in situ phase‐contrast lattice images from a variety of biominerals in magnetotactic bacteria, in particular metastable greigite magnetosomes. Washing tests indicated that specimens adhering to APTES‐primed UV‐B‐irradiated PioloformTM were covalently coupled. The electron beam stability was hypothesised to be the result of mechanical strengthening of the specimen and support film and the reduced electrical resistance in the specimen and support film due to their polymerization and covalent coupling.
Assessment of Streptococcus pneumoniae pilus islet-1 prevalence in carried and transmitted isolates from mother–infant pairs on the Thailand–Burma border

Streptococcus pneumoniae pilus islet-1 (PI-1)-encoded pilus enhances in vitro adhesion to the respiratory epithelium and may contribute to pneumococcal nasopharyngeal colonization and transmission. The pilus subunits are regarded as potential protein vaccine candidates. In this study, we sought to determine PI-1 prevalence in carried pneumococcal isolates and explore its relationship with transmissibility or carriage duration. We studied 896 pneumococcal isolates collected during a longitudinal carriage study that included monthly nasopharyngeal swabbing of 234 infants and their mothers between the ages of 1 and 24 months. These were cultured according to the WHO pneumococcal carriage detection protocol. PI-1 PCR and genotyping by multilocus sequence typing were performed on isolates chosen according to specific carriage and transmission definitions. Overall, 35.2% of the isolates were PI-1-positive, but PI-1 presence was restricted to ten of the 34 serotypes studied and was most frequently associated with serotypes 19F and 23F; 47.5% of transmitted and 43.3% of non-transmitted isolates were PI-1-positive (OR 1.2; 95% CI 0.8–1.7; p 0.4). The duration of first-ever infant pneumococcal carriage was significantly longer with PI-1-positive organisms, but this difference was not significant at the individual serotype level. In conclusion, PI-1 is commonly found in pneumococcal carriage isolates, but does not appear to be associated with pneumococcal transmissibility or carriage duration.