Miracle-dz/UniFAR-FTUs huggingface dataset:
Digital Storytelling : Activating Communicative , Narrative and Digital Competences in Initial Teacher Training

Ocnos: Revista de Estudios sobre lectura. Editada por CEPLI; Universidad de Castilla-La Mancha se distribuye bajo una licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0. Internacional Del-Moral, Ma E. , Villalustre, L. y Neira, Ma R. (2016). Relatos digitales: activando las competencias comunicativa, narrativa y digital en la formación inicial del profesorado. Ocnos, 15 (1), 22-41. doi: 10.18239/ocnos_2016. 15.1. 923 Correspondencia: emoral@uniovi.es Palabras clave Competencia comunicativa; competencia lingüística; alfabetización digital; innovación educativa, formación de profesorado.
A Peculiar New Pampatheriidae (Mammalia: Xenarthra: Cingulata) from the Pleistocene of Argentina and Comments on Pampatheriidae Diversity

Pampatheriidae are a group of cingulates native to South American that are known from the middle Miocene to the lower Holocene. Two genera have been recognized between the lower Pleistocene and the lower Holocene: Pampatherium Gervais and Ameghino (Ensenadan, Bonaerian and Lujanian, lower Pleistocene–lower Holocene) and Holmesina Simpson (Blancan, Irvingtonian, upper Pliocene–lower Holocene). They have been mainly differentiated by their osteoderm morphology and cranio-dental characters. These taxa had a wide latitudinal distribution, extending from the southern part of South America (Península Valdés, Argentina) to North America (Florida, USA). In this contribution, we describe a new genus and species of Pampatheriidae for the lower and middle Pleistocene of Buenos Aires Province and for the upper Pleistocene of Santa Fe Province (Argentina). The new taxon is represented by disarticulated osteoderms, one skull element, two thoracic vertebrae and a right femur and patella. It has extremely complex osteoderm ornamentations and particular morphological characters of the cranial element and femur that are not found in any other species of the family. This new taxon, recorded in the lower–middle Pleistocene (Ensenadan Stage/Age) and in the upper Pleistocene–early Holocene (Lujanian Stage/Age), is incorporated to the Pleistocene mammal assemblage of South America. Finally, the Pampatheriidae diversity is greater during the Lujanian Stage/Age than the Ensenadan Stage/Age.
Essays in Technology Management and Policy:Selected Papers of David J Teece

This book examines the manner in which successful firms develop, transfer, protect, and capture value from technological innovation. In essence, it is about “knowledge management”, which lies at the foundation of firm level competitive advantage in today's global economy. The essays contain some of the fundamental contributions to the field of knowledge management by one of its best-known thinkers; they also constitute an immensely practical guide for those managers who wish to look below the surface of what is going on in Silicon Valley and elsewhere.
Gellner and Geertz in Morocco: A Segmentary Debate

Segmentary lineage theory dominated (especially British) anthropology for about 25 years after the Second World War. In its hey-day it was hailed as one of the greatest theoretical achievements of the discipline (Fortes 1953). At that time the theory was applied to describe social structure of dozens of ‘primitive’ societies around the world. Since the beginning of the 1960s the model has repeatedly came under strong criticism and nowadays, in 2003, it commands little attention. In the meantime, starting in the late 1960s several scholars who had conducted their fieldwork in Morocco published monographs that put the country in the center of anthropological debates on the nature of fieldwork (Dwyer 1982; Rabinow 1977), ethnographic writing (Crapanzano 1980; Munson 1984), and Islam (Eickelman 1976; Geertz 1968; Gellner 1981a). One of the monographs, Saints of the Atlas (1969), made its author Ernest Gellner the main advocate of the segmentary model for the years to come. His compelling argument re-invigorated the segmentary debate and re-focused it on political life of pre-modern Arab and Berber tribes of the Middle East and North Africa. Since then several leading anthropologists have presented widely differing views on the issue and their contributions touched upon important theoretical and epistemological issues of the discipline. The purpose of this paper is to analyze and assess that part of the debate whose participants conducted anthropological fieldwork n Morocco.
Accessible Tourism for the Deaf via Mobile Apps

Accessible tourism seeks to integrate people with impaired abilities --e.g. mobility, vision, hearing-- in travel and leisure activities. The attention to this field has been growing in the past decade, thanks also to technological advancements in smart devices. This paper illustrates the enterprise of accessible tourism applications for smartphones and tablets, tailored for a Deaf Community audience. Specifically, we designed, developed and tested two apps for visiting indoor/outdoor archaeological sites. The apps were implemented for the National Roman Museum Palazzo Massimo, and the open-air archaeological excavation site of Ostia Antica, both in Rome, Italy. The apps are available for free download/use, and have been awarded the European Excellence Award for Accessible Tourism in Brussels, Belgium (2014).
In Vivo Regulation of NGF-Mediated Functions by Nedd4-2 Ubiquitination of TrkA

Trk neurotrophin receptor ubiquitination in response to ligand activation regulates signaling, trafficking, and degradation of the receptors. However, the in vivo consequences of Trk ubiquitination remain to be addressed. We have developed a mouse model with a mutation in the TrkA neurotrophin receptor (P782S) that results in reduced ubiquitination due to a lack of binding to the E3 ubiquitin ligase, Nedd4-2. In vivo analyses of TrkAP782S indicate that defective ubiquitination of the TrkA mutant results in an altered trafficking and degradation of the receptor that affects the survival of sensory neurons. The dorsal root ganglia from the TrkAP782S knock-in mice display an increased number of neurons expressing CGRP and substance P. Moreover, the mutant mice show enhanced sensitivity to thermal and inflammatory pain. Our results indicate that the ubiquitination of the TrkA neurotrophin receptor plays a critical role in NGF-mediated functions, such as neuronal survival and sensitivity to pain.
Mentoring: A Promising Strategy for Youth Development

nterest in mentoring is at an all-time high, with these programs touted as a way to help kids who seem at risk for trouble get on the right track, and also as a way for successful adults to " give something back " to their communities. But popularity does not necessarily equate with effectiveness, which brings us to a critical question: Do mentoring programs work? Or, to put it another way: Are young people who participate in these programs better off because of this participation? To address these questions, Child Trends reviewed studies of ten youth mentoring programs, including both nationwide and locally based programs. Our conclusions about program impacts are based on experimentally designed evaluations. These evaluations compare youth randomly assigned to a mentor-ing program with a group of similar youth who were not so assigned. Seven studies conducted on five of these programs used an experimental design to evaluate the programs. Our conclusions about effective program approaches, however, are generally based on non-experimental analyses. This Research Brief brings together highlights from these multiple studies. The overarching finding from this research is that mentoring programs can be effective tools for enhancing the positive development of youth. Mentored youth are likely to have fewer absences from school, better attitudes towards school, fewer incidents of hitting others, less drug and alcohol use, more positive attitudes toward their elders and toward helping in general, and improved relationships with their parents. But the research also sounds some cautionary notes. For example, it suggests that mentoring relationships of short duration may do more harm than good. Also, in most programs, mentoring was augmented with other services, such as academic support. We conclude this brief with some considerations that policy makers and practitioners may want to keep in mind as they address the needs of at-risk youth. All children need caring adults in their lives. Although positive, sustained relationships with parents represent a critical resource for children, other adults can provide support that is similar to the support that a parent provides. This support from other adults can either be in addition to that provided by a parent or in place of support that a parent refuses or is unable to give. For example, other adults can provide financial assistance, enhance children's learning skills, and help build their self-esteem and self-control. They can also provide emotional support, advice, and guidance about subjects that adolescents might …
Investor Relations, Firm Visibility, and Investor Following

ABSTRACT: We examine the actions and outcomes of investor relations (IR) programs in smaller, less-visible firms. Through interviews with IR professionals, we learn that IR strategies have a common goal of attracting institutional investors and that direct access to management, rather than increased disclosure, is viewed as the key driver of the strategy's success. We test for the effects of IR programs by examining small-cap companies that hired IR firms in a differences-in-differences research design with controls for changes in disclosure and determinants of the decision to initiate IR. Relative to a matched sample of control firms, we find that companies initiating IR programs exhibit greater increases in institutional investor ownership and a shift toward investors that normally would not follow the companies. We also find greater improvements in analyst following, media coverage, and the book-to-price ratio. Our results indicate that IR activities successfully improve visibility, investor following,.
Gazetteer-Independent Toponym Resolution Using Geographic Word Profiles

Toponym resolution, or grounding names of places to their actual locations, is an important problem in analysis of both historical corpora and present-day news and web content. Recent approaches have shifted from rule-based spatial minimization methods to machine learned classifiers that use features of the text surrounding a toponym. Such methods have been shown to be highly effective, but they crucially rely on gazetteers and are unable to handle unknown place names or locations. We address this limitation by modeling the geographic distributions of words over the earth's surface: we calculate the geographic profile of each word based on local spatial statistics over a set of geo-referenced language models. These geo-profiles can be further refined by combining in-domain data with background statistics from Wikipedia. Our resolver computes the overlap of all geo-profiles in a given text span; without using a gazetteer, it performs on par with existing classifiers. When combined with a gazetteer, it achieves state-of-the-art performance for two standard toponym resolution corpora (TR-CoNLL and Civil War). Furthermore, it dramatically improves recall when toponyms are identified by named entity recognizers, which often (correctly) find non-standard variants of toponyms.
Scattering matrices for the quantum N body problem

Let H be a generalized N body Schrödinger operator with very short range potentials. Using Melrose’s scattering calculus, it is shown that the free channel ‘geometric’ scattering matrix, defined via asymptotic expansions of generalized eigenfunctions of H, coincides (up to normalization) with the free channel ‘analytic’ scattering matrix defined via wave operators. Along the way, it is shown that the free channel generalized eigenfunctions of Herbst-Skibsted and Jensen-Kitada coincide with the plane waves constructed by Hassell and Vasy and if the potentials are very short range.
Impact of Facial Conformation on Canine Health: Corneal Ulceration

Concern has arisen in recent years that selection for extreme facial morphology in the domestic dog may be leading to an increased frequency of eye disorders. Corneal ulcers are a common and painful eye problem in domestic dogs that can lead to scarring and/or perforation of the cornea, potentially causing blindness. Exaggerated juvenile-like craniofacial conformations and wide eyes have been suspected as risk factors for corneal ulceration. This study aimed to quantify the relationship between corneal ulceration risk and conformational factors including relative eyelid aperture width, brachycephalic (short-muzzled) skull shape, the presence of a nasal fold (wrinkle), and exposed eye-white. A 14 month cross-sectional study of dogs entering a large UK based small animal referral hospital for both corneal ulcers and unrelated disorders was carried out. Dogs were classed as affected if they were diagnosed with a corneal ulcer using fluorescein dye while at the hospital (whether referred for this disorder or not), or if a previous diagnosis of corneal ulcer(s) was documented in the dogs’ histories. Of 700 dogs recruited, measured and clinically examined, 31 were affected by corneal ulcers. Most cases were male (71%), small breed dogs (mean± SE weight: 11.4±1.1 kg), with the most commonly diagnosed breed being the Pug. Dogs with nasal folds were nearly five times more likely to be affected by corneal ulcers than those without, and brachycephalic dogs (craniofacial ratio <0.5) were twenty times more likely to be affected than non-brachycephalic dogs. A 10% increase in relative eyelid aperture width more than tripled the ulcer risk. Exposed eye-white was associated with a nearly three times increased risk. The results demonstrate that artificially selecting for these facial characteristics greatly heightens the risk of corneal ulcers, and such selection should thus be discouraged to improve canine welfare.
The AGN Outflow in the HDF-S Target QSO J2233–606 from a High-Resolution VLT UVES Spectrum

We present a detailed analysis of the intrinsic UV absorption in the central HDF-S target QSO J2233-606, based on a high-resolution, high-S/N (~25-50) spectrum obtained with VLT UVES. This spectrum samples the cluster of intrinsic absorption systems outflowing from the AGN at radial velocities v ≈ -5000 to -3800 km s-1 in the key far-UV diagnostic lines: the lithium-like CNO doublets and H I Lyman series. We fit the absorption troughs using a global model of all detected lines to solve for the independent velocity-dependent covering factors of the continuum and emission-line sources and ionic column densities. This reveals increasing covering factors in components with greater outflow velocity. Narrow substructure is revealed in the optical depth profiles, suggesting that the relatively broad absorption is comprised of a series of multiple components. We perform velocity-dependent photoionization modeling, which allows a full solution to the C, N, and O abundances, as well as the velocity-resolved ionization parameter and total column density. The absorbers are found to have supersolar abundances, with [C/H] and [O/H] ≈ 0.5-0.9, and [N/H] ≈ 1.1-1.3, consistent with enhanced nitrogen production expected from secondary nucleosynthesis processes. Independent fits to each kinematic component give consistent results for the abundances. The lowest ionization material in each of the strong absorbers is modeled with similar ionization parameters. Components of higher ionization (indicated by stronger O VI relative to C IV and N V) are present at velocities just redward of each low-ionization absorber. We explore the implications of these results for the kinematic-geometric-ionization structure of the outflow.
Estimating Visceral Fat Area by Multi-Frequency Bioelectrical Impedance Running title: Estimating Visceral Fat Area by Impedance

1 Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan 2 Department of Exercise Physiology, Utsunomiya University, Tochigi, Japan. 3 Department of Public Health, Dokkyo University, School of Medicine, Tochigi, Japan. 4 Division of Diabetes and Endocrinology, Department of Internal Medicine, Jikei Daisan University Hospital, Tokyo, Japan. 5 Department of Internal Medicine, Sirasawa Hospital, Tochigi, Japan. 6 TANITA Body Weight Scientific Institute, Tokyo, Japan.
Looking upstream to prevent HIV transmission: can interventions with sex workers alter the course of HIV epidemics in Africa as they did in Asia?

Background:High rates of partner change in ‘upstream’ sex work networks have long been recognized to drive ‘downstream’ transmission of sexually transmitted infections (STIs). We used a stochastic microsimulation model (STDSIM) to explore such transmission dynamics in a generalized African HIV epidemic. Methods:We refined the quantification of sex work in Kisumu, Kenya, from the 4-cities study. Interventions with sex workers were introduced in 2000 and epidemics projected to 2020. We estimated the contribution of sex work to transmission, and modelled standard condom and STI interventions for three groups of sex workers at feasible rates of use and coverage. Results:Removing transmission from sex work altogether would have resulted in 66% lower HIV incidence (range 54–75%) and 56% lower prevalence (range 44–63%) after 20 years. More feasible interventions reduced HIV prevalence from one-fifth to one-half. High rates of condom use in sex work had the greatest effect, whereas STI treatment contributed to HIV declines at lower levels of condom use. Interventions reaching the 40% of sex workers with most clients reduced HIV transmission nearly as much as less targeted approaches attempting to reach all sex workers. Declines were independent of antiretroviral therapy rollout and robust to realistic changes in parameter values. Conclusion:‘Upstream’ transmission in sex work remains important in advanced African HIV epidemics even in the context of antiretroviral therapy. As in concentrated Asian epidemics, feasible condom and STI interventions that reach the most active sex workers can markedly reduce the size of HIV epidemics. Interventions targeting ‘transactional’ sex with fewer clients have less impact.
A Hierarchical Model Predictive Control Approach for Signal Splits Optimization in Large-Scale Urban Road Networks

In this paper, we propose a hierarchical model predictive control (MPC) approach for signal split optimization in large-scale urban road networks. To reduce the computational complexity, a large-scale urban road network is first divided into several subnetworks using a network decomposition method. Second, the MPC optimization problem of the large-scale urban road network is presented, in which the interactions between neighboring subnetworks are described with interconnecting constraints. To coordinate the subnetworks, Lagrange multipliers are introduced to deal with interconnecting constraints among subnetworks, and an augmented Lagrange function is constructed. Then, based on dual optimization theory and a decomposition strategy, the dual optimization problem of the original MPC problem is divided into several new subproblems. In addition, we develop a coordination algorithm based on an interaction prediction approach to coordinate the resulted subproblems with a two-level hierarchical structure. Finally, experimental results by means of simulation on a benchmark road network are presented, which illustrate the performance of the proposed approach.
Characterization and Expression Patterns of microRNAs Involved in Rice Grain Filling

MicroRNAs (miRNAs) are upstream gene regulators of plant development and hormone homeostasis through their directed cleavage or translational repression of the target mRNAs, which may play crucial roles in rice grain filling and determining the final grain weight and yield. In this study, high-throughput sequencing was performed to survey the dynamic expressions of miRNAs and their corresponding target genes at five distinct developmental stages of grain filling. In total, 445 known miRNAs and 45 novel miRNAs were detected with most of them expressed in a developmental stage dependent manner, and the majority of known miRNAs, which increased gradually with rice grain filling, showed negatively related to the grain filling rate. Detailed expressional comparisons revealed a clear negative correlation between most miRNAs and their target genes. It was found that specific miRNA cohorts are expressed in a developmental stage dependent manner during grain filling and the known functions of these miRNAs are involved in plant hormone homeostasis and starch accumulation, indicating that the expression dynamics of these miRNAs might play key roles in regulating rice grain filling.
Incorporation of p-53 mutation status and Ki-67 proliferating index in classifying Her2-neu positive gastric adenocarcinoma

ABSTRACT Her2-neu overexpression has a pathogenetic, therapeutic and a controversial prognostic role in gastric cancer. p-53 mutation status and Ki-67 proliferation index are established prognostic markers in many tumors. In this study we evaluated p-53 and Ki-67 in relation to Her2-neu positive and negative gastric adenocarcinoma (GA). This cross-sectional study was carried out at King Fahd Hospital of Imam Abdulrahman bin Faisal University. Fifty cases of GA were retrieved from pathology archives. Clinico-pathological parameters were evaluated. Immunohistochemical protein analysis for Her2-neu, Ki-67 and p-53 was carried out. Fluorescent in situ hybridization (FISH) analysis was done for Her2-neu positive cases showing 2+ immunoexpression. Frequency of Ki-67 and p-53 positivity in Her2-neu positive cases was calculated and compared with those in Her2-neu negative cases. Correlation of clinicopatological parameters with Her2 positive and negative cases, p-53 mutation status and Ki-67 proliferation index was carried out. Her2-neu overexpression was present in 12% (n = 6) cases. A high Ki-67 was seen predominantly in Her2-neu positive cases (83%, n = 5). Her2-neu negative cases (n = 44) showed moderate (31.88%, n = 14) to low (34%, n = 15) Ki-67. Diffuse p-53 positivity was seen predominantly in Her2-neu positive cases (33.33%, n = 2). Focal p-53 was seen mainly in Her2-neu negative cases 56.8% (n = 25). Negative p-53 was seen to be independent of Her2-neu status. Her2-neu positivity is strongly associated with diffuse p-53 mutation status and high Ki-67 proliferation. Her 2-neu negative status is associated with focal p-53 positivity and low to moderate Ki-67 proliferation index. Such stratifications in prognostic markers could not only be predictive in patient’s prognostics but could also form a basis of molecular classification of gastric cancer.