Miracle-dz/UniFAR-FTUs huggingface dataset:
A New Frontier in Ultralow Power Wireless Links: Network-on-Chip and Chip-to-Chip Interconnects

This paper explores the general framework and prospects for on-chip and off-chip wireless interconnects implemented for high-performance computing (HPC) systems in the context of micro power wireless design. HPC interconnects demand very high (≥ 10 Gb/s) transmission rates using ultraefficient (~ 1 pJ/bit) transceivers over extremely short (≤ 100 cm) ranges. In an attempt to design such wireless interconnects, first a model for the wireless communication channel properties is developed. The use of CMOS-based energyefficient on-off keying (OOK) transceiver architectures operating in the 60-90 GHz bands is considered as a practical solution. In order to address strict performance requirements of wireless HPC interconnects, and taking advantage of the recent developments in device scaling, compact low-power and innovative circuits based on novel double-gate MOSFETs (DG-MOSFETs) are proposed in the implementation of the architecture. The performance of a compact low-noise amplifier (LNA) design using common source (CS) inductive degeneration with 32 nm DGMOSFETs is investigated by quantitative analysis and simulation. The proposed inductor-less two-stage cascode cascade LNA is optimized for 90 GHz operation and has the advantage of gain switching over its CMOS counterpart without the use of additional switching transistors, which makes it remarkably power efficient and faster. As further examples of efficient and compact DG-MOSFET circuits for OOK transceiver design, a three-stage CS 5 dB tunable power amplifier operating up to 90 GHz, and a novel 90 GHz voltage controlled oscillator are also presented. This is followed by the proposal of an array of four monopole antennas studied using full-wave EM solver.
Trigger factors for familial hemiplegic migraine

Objective: The aim was to identify and describe migraine trigger factors in patients with familial hemiplegic migraine (FHM) from a population-based sample. Methods: 127 FHM patients were sent a questionnaire listing 16 trigger factors. Distinction was made between attacks of hemiplegic migraine (HM) and migraine with aura (MA) or without aura (MO) within each patient. Results: The response rate was 59% (75/127) of whom 57 (76%) had current HM attacks. Sixty-three per cent (47/75) reported at least one factor triggering HM, and 36% (27/75) reported at least one factor that often or always caused HM. Twenty per cent (15/75) reported only HM, whereas FHM in combinations with MA and MO were reported by 80% (60/75). Stress (with attacks either following or during the stress), bright light, intense emotional influences and sleeping too much or too little were the trigger factors mentioned by most. Conclusion: Many FHM patients report trigger factors and one-third reported at least one trigger factor often or always triggering FHM. The typical triggers are the same as for MA. Patients should be educated to avoid these factors. The role of trigger factors in the onset of new or first attacks of FHM remains unknown.
Multifunctional Bismuth‐Doped Nanoporous Silica Glass: From Blue‐Green, Orange, Red, and White Light Sources to Ultra‐Broadband Infrared Amplifiers

Ultra‐broadband luminescent sources that emit light over an extremely wide wavelength range are of great interest in the fields of photonics, medical treatment, and precision measurement. Extensive research has been conducted on materials doped with rare‐earth and transition‐metal ions, but the goal of fabricating an ultra‐broadband emitter has not been attained. We present a facile method to realize this kind of novel light source by stabilizing “active” centers (bismuth) in a “tolerant” host (nanoporous silica glass). The obtained highly transparent materials, in which, unusually, multiple bismuth centers (Bi+, Bi2+, and Bi3+) can be stabilized, emit in an ultra‐broadband wavelength range from blue‐green, orange, red, and white to the near‐infrared region. This tunable luminescence covers the spectral range of the traditional three primary colors (RGB) and also the telecommunications windows.
Type Ia supernova SN 2003du: optical observations

UBVRI photometry and optical spectra of type Ia supernova SN 2003du obtained at the Indian Astronomical Observatory for nearly a year since discovery are presented. The apparent magnitude at maximum was B = 13.53 ± 0.02 mag, and the colour (B − V) = −0.08 ± 0.03 mag. The luminosity decline rate, ∆m15(B) = 1.04 ± 0.04 mag indicates an absolute B magnitude at maximum of M max = −19.34 ± 0.3 mag and the distance modulus to the parent galaxy as µ = 32.89 ± 0.4. The light curve shapes are similar, though not identical, to those of SNe 1998bu and 1990N, both of which had luminosity decline rates similar to that of SN 2003du and occurred in spiral galaxies. The peak bolometric luminosity indicates that ∼0.9 Mmass of 56 Ni was ejected by the supernova. The spectral evolution and the evolution of the Si II and Ca II absorption velocities closely follows that of SN 1998bu, and in general, is within the scatter of the velocities observed in normal type Ia supernovae. The spectroscopic and photometric behaviour of SN 2003du is quite typical for SNe Ia in spirals. A high velocity absorption component in the Ca II (H and K) and IR-triplet features, with absorption velocities of ∼20 000 km s −1 and ∼22 000 km s −1 respectively, is detected in the pre-maximum spectra of days −11 and −7.
Macular hole size as a prognostic factor in macular hole surgery

Background/aim: In 1991 there was a series of successful closures of a macular hole after vitrectomy and membrane peeling. Today this technique has become a standard procedure. The aim of this study was to evaluate the role of optical coherence tomography in diagnosing and staging, as well as in predicting, the functional and anatomical outcome after macular hole surgery. Method: In a prospective study 94 consecutive patients (20 male, 74 female) with a mean age of 67.6 (SD 6.0) years and a macular hole stage II (n = 8), III (n = 72), and IV (n = 14) according to the classification by Gass were examined with optical coherence tomography (OCT) before pars plana vitrectomy. Macular hole diameters were determined at the level of the retinal pigment epithelium (base diameter) and at the minimal extent of the hole (minimum diameter). Calculated hole form factor (HFF) was correlated with the postoperative anatomical success rate and best corrected visual acuity. The duration of symptoms was correlated with base and minimum diameter of the macular hole. Results: In eyes without anatomical closure of the macular hole after one surgical approach (13/94) the base diameter (p1) and the minimum diameter (p2) were significantly larger than in cases with immediate postsurgical closure (p1 = 0.003; p2 = 0.028). There was a significant negative correlation between both the base and the minimum diameter of the hole and the postoperative visual function (p1 = 0.016; p2 = 0.002). In all patients with HFF >0.9 the macular hole was closed following one surgical procedure, whereas in eyes with HFF <0.5 anatomical success rate was 67%. Better postoperative visual outcome correlated with higher HFF (p = 0.050). There was no significant correlation between the duration of symptoms and base or minimum diameters (p1 = 0.053; p2 = 0.164), respectively. Conclusion: Preoperative measurement of macular hole size with OCT can provide a prognostic factor for postoperative visual outcome and anatomical success rate of macular hole surgery. The duration of symptoms did not correlate with the diameters measured. Base and minimum diameters especially seem to be of predictive value in macular hole surgery.
Quality characteristics of bread and cookies enriched with debittered Moringa oleifera seed flour

The effects of replacing wheat flour with 0–15% debittered moringa seed (DBMS) flour on the dough rheology of wheat flour and physical, sensory and chemical properties of bread were studied. Incorporation of an increasing amount of DBMS from 0 to 15% decreased farinograph water absorption, dough stability, amylograph peak viscosity and overall quality of bread. The bread with 10% DBMS had a typical moringa seed taste and was acceptable. Addition of combination of additives improved the dough strength and quality of bread with 10% DBMS flour. Replacement of wheat flour with 10%, 20% and 30% DBMS grits was found to affect cookies quality. Cookies with 20% DBMS grits had the nutty taste of moringa seeds and were acceptable. Bread with 10% DBMS flour and cookies with 20% DBMS grits had more protein, iron and calcium. Incorporating moringa seeds in baked foods may be exploited as a means of boosting nutrition in Africa and Asia where malnutrition is prevalent.
Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans

The identification of quantitative trait loci (QTLs) of small effect size that underlie complex traits poses a particular challenge for geneticists due to the large sample sizes and large numbers of genetic markers required for genomewide association scans. An efficient solution for screening purposes is to combine single nucleotide polymorphism (SNP) microarrays and DNA pooling (SNP-MaP), an approach that has been shown to be valid, reliable and accurate in deriving relative allele frequency estimates from pooled DNA for groups such as cases and controls for 10K SNP microarrays. However, in order to conduct a genomewide association study many more SNP markers are needed. To this end, we assessed the validity and reliability of the SNP-MaP method using Affymetrix GeneChip® Mapping 100K Array set. Interpretable results emerged for 95% of the SNPs (nearly 110 000 SNPs). We found that SNP-MaP allele frequency estimates correlated 0.939 with allele frequencies for 97 605 SNPs that were genotyped individually in an independent population; the correlation was 0.971 for 26 SNPs that were genotyped individually for the 1028 individuals used to construct the DNA pools. We conclude that extending the SNP-MaP method to the Affymetrix GeneChip® Mapping 100K Array set provides a useful screen of >100 000 SNP markers for QTL association scans.
Inferring subjective states through the observation of actions

Estimating another person's subjective confidence is crucial for social interaction, but how this inference is achieved is unknown. Previous research has demonstrated that the speed at which people make decisions is correlated with their confidence in their decision. Here, we show that (i) subjects are able to infer the subjective confidence of another person simply through the observation of their actions and (ii) this inference is dependent upon the performance of each subject when executing the action. Crucially, the latter result supports a model in which motor simulation of an observed action mediates the successful understanding of other minds. We conclude that kinematic understanding allows access to the higher-order cognitive processes of others, and that this access plays a central role in social interactions.
Human immunodeficiency virus type 1 (HIV‐1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages

Human immunodeficiency virus type 1 (HIV‐1) impacts the activation state of multiple lineages of hematopoietic cells. Chronic HIV‐1 infection among individuals with progressive disease can be associated with increased levels of activated signal transducers and activators of transcription (STATs) in peripheral blood mononuclear cells. To investigate interactions between HIV‐1 and CD4+ cells, activated, phosphorylated STAT proteins in nuclear extracts from lymphocytic and promonocytic cell lines as well as primary monocyte‐derived macrophages were measured. Levels of activated STATs increased six‐ to tenfold in HUT78 and U937 cells within 2 h following exposure to virions. The response to virus was dose‐dependent, but kinetics of activation was delayed relative to interleukin‐2 or interferon‐γ. Activation of STAT1, STAT3, and STAT5 occurred with diverse viral envelope proteins, independent of coreceptor use or viral replication. Envelope‐deficient virions had no effect on STAT activation. Monoclonal antibody engagement of CD4 identified a novel role for CD4 as a mediator in the activation of multiple STATs. Results provide a model for HIV‐1 pathogenesis in infected and noninfected hematopoietic cells.
Effects of blood pressure on the prothrombotic risk in 1235 patients with non-valvular atrial fibrillation

Background: Increased levels of plasma von Willebrand factor (vWf, an index of endothelial damage/dysfunction) and soluble P-selectin (sP-sel, an index of platelet activation) concentrations have been reported as indices of the prothrombotic state in both non-valvular atrial fibrillation and hypertension separately. However, the effect of hypertension on the levels of these indices in the setting of atrial fibrillation, and whether increasing severity of hypertension presents an additive prothrombotic risk, is unclear. Methods: Plasma concentrations of vWf and sP-sel were measured by ELISA in 1235 patients with atrial fibrillation, and levels related to a history of hypertension and rising quartiles of systolic, diastolic and pulse pressure in those with and without diabetes mellitus and prior vascular events. Results: Mean plasma vWf was higher among patients with atrial fibrillation with a history of hypertension (149 vs 145 IU/dl, p = 0.005). Also, an increase in the levels of vWf with increasing quartiles of pulse pressure (p = 0.042) was noticed. However, on multivariate analysis, after adjusting for potential confounders, the effects of both hypertension and pulse pressure became non-significant (p = 0.261 and p = 0.5, respectively). Levels of sP-sel were unaffected by a history of hypertension and rising quartiles of systolic and diastolic blood pressure, or pulse pressure. Conclusion: Among patients with atrial fibrillation, patients with hypertension have higher vWf levels, indicating endothelial damage/dysfunction, which is associated with increasing pulse pressure. However, these associations are probably owing to the presence of other associated cardiovascular disease, rather than hypertension itself. Furthermore, platelet activation (sP-sel) was unrelated to hypertension or blood pressure in this atrial fibrillation cohort. Hypertension or blood pressure levels do not seem to have an independent additive affect on the prothrombotic state in atrial fibrillation.
A New reduction of the raw Hipparcos data

We present an outline of a new reduction of the Hipparcos astrometric data, the justifications of which are described in the accompanying paper. The emphasis is on those aspects of the data analysis that are fundamentally different from the ones used for the catalogue published in 1997. The new reduction uses a dynamical modelling of the satellite's attitude. It incorporates provisions for scan-phase discontinuities and hits, most of which have now been identified. Solutions for the final along-scan attitude (the reconstruction of the satellite's scan phase), the abscissa corrections and the instrument model, originally solved simultaneously in the great-circle solution, are now de-coupled. This is made possible by starting the solution iterations with the astrometric data from the published catalogue. The de-coupling removes instabilities that affected great-circle solutions for short data sets in the published data. The modelling-noise reduction implies smaller systematic errors, which is reflected in a reduction of the abscissa-error correlations by about a factor 40. Special care is taken to ensure that measurements from both fields of view contribute significantly to the along-scan attitude solution. This improves the overall connectivity of the data and rigidity of the reconstructed sky, which is of critical importance to the reliability of the astrometric data. The changes in the reduction process and the improved understanding of the dynamics of the satellite result in considerable formal-error reductions for stars brighter than 8th magnitude.
Siegel Modular Forms

Lectures on Siegel modular forms given in Nordfjordeid. Besides a survey on Siegel modular forms it presents the joint work with Carel Faber on vector-valued Siegel modular forms of genus 2 and it gives evidence for a conjecture of Harder on congruences between g=1 and g=2 forms.
Ambient temperature influences aging in an annual fish (Nothobranchius rachovii)

Extending lifespan by lowering ambient temperature in the habitat has been shown in a variety of organisms. Its mechanism, however, remains elusive. In this study, we examined the survivorship and the aging process of the annual fish (Nothobranchius rachovii) reared under high (30 °C), moderate (25 °C) and low (20 °C) ambient temperatures. The results showed that low ambient temperatures prolong survivorship, whereas high ambient temperatures shorten survivorship. At low ambient temperature, expression of senescence‐associated β‐galactosidase, lipofuscin, reactive oxygen species, lipid peroxidation, protein oxidation, mitochondrial density and ADP/ATP ratio were reduced compared with those reared at high and moderate temperatures, whereas catalase activity, Mn‐superoxide dismutase activities, mitochondrial membrane potential and the levels of ATP, ADP, Sirt1 and Forkhead box O expression were elevated. The expression levels of Hsp70 and CIRP showed no significant difference under any of the ambient temperatures tested. We concluded that cellular metabolism, energy utilization and gene expression are altered at lower ambient temperature, which is associated with the extension of lifespan of the annual fish.
APS8, a Polymeric Alkylpyridinium Salt Blocks α7 nAChR and Induces Apoptosis in Non-Small Cell Lung Carcinoma

Naturally occurring 3-alkylpyridinium polymers (poly-APS) from the marine sponge Reniera sarai, consisting of monomers containing polar pyridinium and nonpolar alkyl chain moieties, have been demonstrated to exert a wide range of biological activities, including a selective cytotoxicity against non-small cell lung cancer (NSCLC) cells. APS8, an analog of poly-APS with defined alkyl chain length and molecular size, non-competitively inhibits α7 nicotinic acetylcholine receptors (nAChRs) at nanomolar concentrations that are too low to be acetylcholinesterase (AChE) inhibitory or generally cytotoxic. In the present study we show that APS8 inhibits NSCLC tumor cell growth and activates apoptotic pathways. APS8 was not toxic for normal lung fibroblasts. Furthermore, in NSCLC cells, APS8 reduced the adverse anti-apoptotic, proliferative effects of nicotine. Our results suggest that APS8 or similar compounds might be considered as lead compounds to develop antitumor therapeutic agents for at least certain types of lung cancer.
Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK-3β signaling pathway

AIM To evaluate the effect of oxymatrine (OMT) on hepatocyte apoptosis in rats with lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute liver failure (ALF). METHODS LPS/D-GalN was used to establish a model of ALF in rats. To evaluate the effect of OMT, we assessed apoptosis by transmission electron microscopy, and the pathological changes in the liver by light microscopy with hematoxylin and eosin staining. An automated biochemical analyzer was used to measure serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Enzyme-linked immunosorbent assay was used to determine the levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1β. Western blotting was used to detect protein levels in liver tissues. Streptavidin peroxidase immunohistochemistry was used to observe expression of Toll-like receptor (TLR)4, active caspase-3, Bax and Bcl-2. RESULTS All rats in the normal control and OMT-pretreated groups survived. The mortality rate in the model group was 30%. OMT preconditioning down-regulated apoptosis of hepatocytes and ameliorated pathological changes in liver tissue. The levels of AST, ALT, TNF-α and IL-1β in the model group increased significantly, and were significantly reduced by OMT pretreatment. OMT pretreatment down-regulated expression of TLR4 and active caspase-3 and the Bax/Bcl-2 ratio, and up-regulated expression of P-AktSer473 (Akt phosphorylated at serine 473) and P-GSK3βSer9 (glycogen synthase kinase 3β phosphorylated at serine 9) induced by LPS/D-GalN. CONCLUSION OMT inhibits hepatocyte apoptosis by suppressing the TLR4/PI3K/Akt/GSK-3β signaling pathway, which suggests that OMT is an effective candidate for ameliorating acute liver failure.
Gastroprotective Effect of an Aqueous Suspension of Black Cumin Nigella sativa on Necrotizing Agents-Induced Gastric Injury in Experimental Animals

Background/Aim Previous studies on “Black seed” or “Black Cumin” Nigella sativa (NS) have reported a large number of pharmacological activities including its anti-ulcer potential. These studies employed either fixed oil, volatile oil components or different solvent extracts. In folkloric practices, NS seeds are taken as such, in the form of coarse dry powder or the powdered seeds are mixed with water. This study examines the effect of NS aqueous suspension on experimentally induced gastric ulcers and basal gastric secretion in rats to rationalize its use by herbal and Unani medicine practitioners. Materials and Methods The study was conducted at the Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Acute gastric ulceration was produced by various noxious chemicals (80% ethanol, 0.2 M NaOH, 25% NaCl and indomethacin) in Wistar albino rats. Anti-secretory studies were undertaken in a separate group of rats. Gastric wall mucus contents and non-protein sulfhydryl concentration were estimated, and gastric tissue was examined histopathologically. Results An aqueous suspension of Black seed significantly prevented gastric ulcer formation induced by necrotizing agents. It also significantly ameliorated the ulcer severity and basal gastric acid secretion in pylorus-ligated Shay rats. Moreover, the suspension significantly replenished the ethanol-induced depleted gastric wall mucus content levels and gastric mucosal non-protein sulfhydryl concentration. The anti-ulcer effect was further confirmed histopathologically. Conclusion These findings validate the use of Black seed in gastropathies induced by necrotizing agents. The anti-ulcer effect of NS is possibly prostaglandin-mediated and/or through its antioxidant and anti-secretory activities.
Palmprint Recognition across Different Devices

In this paper, the problem of Palmprint Recognition Across Different Devices (PRADD) is investigated, which has not been well studied so far. Since there is no publicly available PRADD image database, we created a non-contact PRADD image database containing 12,000 grayscale captured from 100 subjects using three devices, i.e., one digital camera and two smart-phones. Due to the non-contact image acquisition used, rotation and scale changes between different images captured from a same palm are inevitable. We propose a robust method to calculate the palm width, which can be effectively used for scale normalization of palmprints. On this PRADD image database, we evaluate the recognition performance of three different methods, i.e., subspace learning method, correlation method, and orientation coding based method, respectively. Experiments results show that orientation coding based methods achieved promising recognition performance for PRADD.