Miracle-dz/UniFAR-FTUs huggingface dataset:
Pistachio Nut Consumption Modifies Systemic Hemodynamics, Increases Heart Rate Variability, and Reduces Ambulatory Blood Pressure in Well‐Controlled Type 2 Diabetes: a Randomized Trial

Background Managing cardiovascular risk factors is important for reducing vascular complications in type 2 diabetes, even in individuals who have achieved glycemic control. Nut consumption is associated with reduced cardiovascular risk; however, there is mixed evidence about the effect of nuts on blood pressure (BP), and limited research on the underlying hemodynamics. This study assessed the effect of pistachio consumption on BP, systemic hemodynamics, and heart rate variability in adults with well‐controlled type 2 diabetes. Methods and Results We enrolled 30 adults (40 to 74 years) with type 2 diabetes in a randomized, crossover, controlled feeding study. After a 2‐week run‐in period, participants consumed a low‐fat control diet (27% fat) containing low‐fat/high‐carbohydrate snacks and a moderate‐fat diet (33% fat) containing pistachios (20% of total energy) for 4 weeks each, separated by a 2‐week washout. Following each diet period, we assessed BP, systemic hemodynamics, and heart rate variability at rest and during acute mental stress, and, in a subset of participants (n=21), 24‐hour ambulatory BP. BP at rest and during stress did not differ between treatments. The pistachio diet significantly reduced total peripheral resistance (−3.7±2.9%, P=0.004), increased cardiac output (3.1±2.3%, P=0.002), and improved some measures of heart rate variability (all P<0.05). Systolic ambulatory BP was significantly reduced by 3.5±2.2 mm Hg (P=0.046) following the pistachio diet, with the greatest reduction observed during sleep (−5.7±2.6 mm Hg, P=0.052). Conclusions A moderate‐fat diet containing pistachios modestly improves some cardiovascular risk factors in adults with well‐controlled type 2 diabetes. Clinical Trial Registration URL: www.clinicaltrials. gov. Unique identifier: NCT00956735.
Comparison of the Shaping Ability of WaveOne Reciprocating Files with or without Glide Path in Simulated Curved S-shaped Root Canals

Objectives: The aim was to compare the shaping ability of WaveOne reciprocating files with or without glide path in simulated curved S-shaped root canals. Materials and Methods: Forty ISO #15, 0.02 taper, clear resin Endo Training Bloc-S blocks were studied. The simulated curved S-shaped canals were dyed using ink, preinstrumentation images were scanned, and resin blocks were prepared and divided into Group A: PathFile and WaveOne and Group B: WaveOne. All canals were postoperatively scanned. Pre- and postoperative images were superimposed and evaluated at 12 defined measuring points. The efficacy of the systems was compared based on the amount and direction of canal transportation, centering ability, amount of material removed, and presence of canal aberrations. Mann–Whitney U-test and independent t-test were used for statistical comparison. Results: Both systems produced transportation at all levels and straightened the curved S-shaped canals. No significant differences in the amount and direction of transportation and amount of material removed were observed between the groups at each level (P > 0.05). However, Group A had significantly greater centering ability at the coronal straight zone (P = 0.018) and apical curvature (P = 0.014) levels than did Group B. Moreover, Group B showed more canal aberrations than did Group A. Conclusion: Within the limitations of the present study, the creation of a glide path with the PathFile system improved the centering ability of the WaveOne reciprocating file in the apical and straight coronal portions of the simulated curved S-shaped root canals and reduced the incidence of canal aberrations.
Case‐control study of risk factors for cervical neoplasia in Denmark. I: Role of the “male factor” in women with one lifetime sexual partner

Possible risk factors for cervical cancer were investigated in 645 women, 20–49 years of age from Copenhagen, with histologically confirmed cervical cancer or carcinoma in situ and in 614 controls drawn at random from the female population of the same area. To study the role of the “male factor”, monogamous cases and controls together with their husbands were invited for further examination. This included a personal interview, a blood sample for analysis of herpes simplex virus antibodies, and a penile swab for papillomavirus analysis. In total, 41 case couples and 90 control couples were enrolled (89% and 92% of eligibles, respectively). The most significant risk determinants were a history of genital warts in the male (RR = 17.9 for ever vs. never) and ever having used condoms (RR = 0.2). Other potentially important factors, although not statistically significant, were ever having visited prostitutes (RR = 2.6, p = 0.14), circumcision (RR = 0.3, p=0.18), and a history of genital warts in the female (RR = 4.6, p= 0.09). Having a husband with a history of multiple sexual partners was also associated with an increased crude risk, but when adjustment was made for husband ever having had genital warts, use of condom, and age, no significant excess risk was observed. Human papillomavirus DNA, which was tested for with ViraPap and ViraType, was detected in one of the controls, and in only 2 case husbands. This study points to the importance of “high‐risk males” for the development of cervical cancer in their sexual partner; the results support the infectious nature of the disease.
Adhesions and Adhesiolysis: The Role of Laparoscopy

Background: Adhesions commonly result from abdominal and pelvic surgical procedures and may result in intestinal obstruction, infertility, chronic pain, or complicate subsequent operations. Laparoscopy produces less peritoneal trauma than does conventional laparotomy and may result in decreased adhesion formation. We present a review of the available data on laparoscopy and adhesion formation, as well as laparoscopic adhesiolysis. We also review current adjuvant techniques that may be used by practicing laparoscopists to prevent adhesion formation. Database: A Medline search using “adhesions,” “adhesiolysis,” and “laparoscopy” as key words was performed for English-language articles. Further references were obtained through cross-referencing the bibliography cited in each work. Discussion: The majority of studies indicate that laparoscopy may reduce postoperative adhesion formation relative to laparotomy. However, laparoscopy by itself does not appear to eliminate adhesions completely. A variety of adjuvant materials are available to surgeons, and the most recent investigation has demonstrated significant potential for intraperitoneal barriers. Newer technologies continue to evolve and should result in clinically relevant reductions in adhesion formation.
Comparison of large-scale amplitude modulation in turbulent boundary layers, pipes, and channel flows

Recent investigations by Monty et al. [J. Fluid Mech. 632, 431 (2009)] showed that important modal differences exist between channels/pipes and boundary layers, mainly in the largest energetic scales. In addition, Mathis et al. [J. Fluid Mech. 628, 311 (2009)] recently reported and quantified a nonlinear scale interaction in zero-pressure gradient turbulent boundary layers, whereby the large-scale motion amplitude modulates the small-scale motions. In this study, a comparison of this modulation effect of the streamwise velocity component is undertaken for all three flows for matched Reynolds number and measurement conditions. Despite the different large-scale phenomena in these internal and external wall-bounded flows, the results show that their amplitude modulation influence remains invariant in the inner region with some differences appearing in the outer region.
A metric-based analysis of web sites in Serbia: first findings

Web engineering can be defined as a disciplined and systematic approach to development, deployment and maintenance of high-quality web applications. It borrows many principles, processes, methods and tools from software engineering and measurements and metrics are among them. The research on web metrics already done provides evidence that even simple HTML tag based metrics can be useful in evaluating quality attributes of web applications and in information retrieval. In this paper we study a number of web sites in Serbia in terms of HTML metrics gathered from the sites' web pages in order to compare the statistics of metrics with the results coming from a more advanced domain of the Web and presented in a previous work. We want to determine if our web pages are high-quality pages. The study covers web sites from educational and financial topics. Our analysis shows that the results obtained from web sites of banks in Serbia are very close to the results given in the previous work. The foreign banks in Serbia contribute to this mostly. In addition, our analysis finds out that schools of engineering of the University of Belgrade have the best web sites when the statistical features of HTML metrics are compared to those given in the previous work. A special tool for extracting metrics from HTML code automatically, named SMeterH, has been used in our analysis.
Trusting Humans and Avatars: A Brain Imaging Study Based on Evolution Theory

Avatars, as virtual humans possessing realistic faces, are increasingly used for social and economic interaction on the Internet. Research has already determined that avatar-based communication may increase perceived interpersonal trust in anonymous online environments. Despite this trust-inducing potential of avatars, however, we hypothesize that in trust situations, people will perceive human faces differently than they will perceive avatar faces. This prediction is based on evolution theory, because throughout human history the majority of interaction among people has taken place in face-to-face settings. Therefore, unlike perception of an avatar face, perception of a human face and the related trustworthiness discrimination abilities must be part of the genetic makeup of humans. Against this background, we conducted a functional magnetic resonance imaging experiment based on a multiround trust game to gain insight into the differences and similarities of interactions between humans versus human interaction with avatars. Our results indicate that (1) people are better able to predict the trustworthiness of humans than the trustworthiness of avatars; (2) decision making about whether or not to trust another actor activates the medial frontal cortex significantly more during interaction with humans, if compared to interaction with avatars; this brain area is of paramount importance for the prediction of other individuals' thoughts and intentions (mentalizing), a notably important ability in trust situations; and (3) the trustworthiness learning rate is similar, whether interacting with humans or avatars. Thus, the major implication of this study is that although interaction on the Internet may have benefits, the lack of real human faces in communication may serve to reduce these benefits, in turn leading to reduced levels of collaboration effectiveness.
Strategies for prevention of scars: what can we learn from fetal skin?

Fetal wound healing occurs rapidly and without scar formation early in gestation. Studying the mechanisms of scarless repair can lead to novel scar‐preventive approaches. In fetal wounds, collagen is deposited early and is fine and reticular with less cross‐linking. Several important differences of fetal vs. postgestational wound‐healing response have been determined, such as the presence of less inflammation, higher hyaluronic acid concentration and a greater ratio of collagen type III to type I. Compared with typical wounds, there are also altered ratios of signaling molecules, such as higher ratios of transforming growth factor (TGF)‐β3 to TGF‐β1 and ‐β2, and matrix metalloproteinases to tissue inhibitors of metalloproteinases. Furthermore, fetal fibroblasts do not exhibit TGF‐β1‐induced collagen production compared with their mature counterparts. Patterning genes (homeobox genes) involved in organogenesis are more active in the fetal period and are believed to be the “first domino” in the fetal cutaneous wound repair regulatory cascade. The recommended scar‐preventive agents, such as Scarguard MD®, silicone gel and sheet, Seprafilm® Bioresorbable Membrane, topical hyaluronan, onion extract, oral tamoxifen and 585‐nm pulsed dye laser are reviewed in this study. Despite the lack of supporting evidence, there is a widespread false presumption that the acceleration of healing with the widely assumed scar‐preventive commercial agents is associated with decreased scar formation. Humans are erroneously inclined to make a negative correlation between the healing rate and the degree of scar formation, while such a correlation does not exist in reality. Despite the importance of scar prevention, no FDA‐approved therapy for this purpose is available in the 21st century, which reflects the important challenges, such as the presence of redundant pathways, that these approaches are facing.
Wnt6 Is Essential for Stromal Cell Proliferation During Decidualization in Mice1

ABSTRACT Postimplantation uterine development involves extensive stromal cell proliferation and decidual transformation with polyploidization, which is essential for normal pregnancy establishment. However, it remains largely unknown how stromal proliferation versus decidual polyploidization is differentially regulated during decidualization. Utilizing Wnt6-mutant mice, we show here that Wnt6 deficiency impairs stromal cell proliferation without much adverse effects on decidual polyploidization. Applying a primary stromal cell culture model, we further reveal that loss of Wnt6 prolongs the cell cycle length via downregulating cyclin B1 expression, thus attenuating stromal cell proliferation. Our study provides the first genetic evidence that Wnt6 is critical for normal stromal cell proliferation in mice, highlighting the concept that there are differential machineries governing the process of stromal cell proliferation versus decidual transformation during early pregnancy. This finding has high clinical relevance because Wnt signaling is known to be important for human implantation and endometrial function.
Cardiac veins: A review of the literature

Cardiac veins have long stood in the shadow of their more extensively studied counterparts, the coronary arteries. The clinical importance of the coronary venous system, nonetheless, should not be underestimated. Intricate and beneficial therapeutic options are increasingly being developed that depend on knowledge of the structure of this venous network. Such interventions have been shown greatly to promote cardiac health, and to enhance the efficacy of cardiac pacing. A comprehensive appreciation of the architecture of the coronary venous system, therefore, is crucial to optimal cardiac care. It is possible to provide an overview of the arrangement of the cardiac veins, with the larger veins draining to the coronary sinus, and thence to the right atrium, but with smaller and minimal veins draining directly to the cavities of the atrial chambers. The venous pathways, nonetheless, are highly variable, making exceptions the commonly accepted rule. As such, unique solutions for imaging, and simple attentiveness to possible venous variations, can greatly enhance clinical outcomes. For example, identifying the diameter, course, and valves of the cardiac veins allows for anticipation of impediments during interventional procedures, and allows for informed clinical decision‐making. Also of significance is awareness of alternate arrangements that may be encountered in terms of venous drainage, and the importance of intramural venous collecting spaces in these patterns. The objective of our review, therefore, is to explore and describe the anatomical distribution of the coronary veins Clin. Anat. 22:129–145, 2009. © 2008 Wiley‐Liss, Inc.
Human metapneumovirus infection in hematopoietic stem cell transplant recipients

M.C. Debur, L.R. Vidal, E. Stroparo, M.B. Nogueira, S.M. Almeida, G.A. Takahashi, I. Rotta, L.A. Pereira, C.S. Silveira, C.M. Bonfim, S.M. Raboni. Human metapneumovirus infection in hematopoietic stem cell transplant recipients. Transpl Infect Dis 2010: 12: 173–179. All rights reserved
Indicator medium for isolation of Campylobacter pylori

The use of a new indicator culture medium, Belo Horizonte medium, is proposed for better colony recognition and a presumptive identification of Campylobacter pylori. This medium, containing brain heart infusion sheep blood agar, was supplemented with 40 mg of 2,3,5-triphenyltetrazolium chloride per liter in addition to vancomycin, nalidixic acid, and amphotericin B. On Belo Horizonte medium, Campylobacter pylori present unique golden colonies.
Adjuvant radiotherapy for stage I endometrial cancer: an updated Cochrane systematic review and meta-analysis.

BACKGROUND The role of adjuvant radiotherapy in stage I endometrial cancer has changed in recent years. This updated Cochrane systematic review aimed to reexamine the efficacy and toxicity of adjuvant radiotherapy vs no treatment in stage I endometrial cancer. METHODS We searched various databases including The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and the Specialised Register of the Cochrane Gynaecological Cancer Review Group (CGCRG) for randomized controlled trials that met the predefined inclusion criteria. The primary outcome was overall survival (OS); secondary outcomes were endometrial cancer-specific survival, locoregional recurrence, distant recurrence, and toxicity. Hazard ratios (HRs) were estimated and pooled if possible; otherwise, dichotomous data were extracted. All statistical tests were two-sided. RESULTS Of the eight included trials, seven trials (3628 women) compared external beam radiotherapy (EBRT) and no EBRT (or vaginal brachytherapy [VBT]), and one trial (645 women) compared VBT and no additional treatment. EBRT statistically significantly reduced locoregional recurrence compared with no EBRT (or VBT alone) (HR = 0.36, 95% confidence Interval [CI] = 0.25 to 0.52; P < .001), but this did not translate into an improvement in OS (HR = 0.99, 95% CI = 0.82 to 1.20; P = .95), endometrial cancer-specific survival (HR = 0.96, 95% CI = 0.72 to 1.28; P = .80), or distant recurrence rates (risk ratio = 1.04, 95% CI = 0.80 to 1.35; P = .77). EBRT was associated with an increased risk of severe acute toxicity, severe late toxicity, and reduced quality of life scores. CONCLUSIONS EBRT reduces the risk of locoregional recurrence but has no statistically significant impact on cancer-related deaths or OS. However, EBRT is associated with clinically and statistically significant morbidity and a reduction in quality of life.
Collateralization of monoamine neurons: mesotelencephalic dopamine projections to caudate, septum, and frontal cortex

Axonal collateralization of substantia nigra (SN) and ventral tegmental area (VTA) neurons was studied in the rat with the multiple retrograde labeling technique using fluorescent dyes. Injections of nuclear yellow, granular blue, and propidium iodide were made into the caudate- putamen, septum, and frontal cortex and cells were found to be single, double, and triple labeled in the SN-VTA. Cells in the VTA were predominantly single labeled with the three tracers and cells in the medial SN were predominantly double labeled with the tracers. These results suggest that mesotelencephalic neurons in the SN-VTA can be subdivided into two subpopulations on the basis of relative degree of collateralization. The SN axons appear to be highly collateralized to anatomically and functionally distinct telencephalic areas and the VTA axons appear to have a more singular one-to-one type of projection to the same forebrain regions.
Data-Driven Broad-Coverage Grammars for Opinionated Natural Language Generation (ONLG)

Opinionated Natural Language Generation (ONLG) is a new, challenging, task that aims to automatically generate human-like, subjective, responses to opinionated articles online. We present a data-driven architecture for ONLG that generates subjective responses triggered by users’ agendas, consisting of topics and sentiments, and based on wide-coverage automatically-acquired generative grammars. We compare three types of grammatical representations that we design for ONLG, which interleave different layers of linguistic information and are induced from a new, enriched dataset we developed. Our evaluation shows that generation with Relational-Realizational (Tsarfaty and Sima’an, 2008) inspired grammar gets better language model scores than lexicalized grammars ‘a la Collins (2003), and that the latter gets better human-evaluation scores. We also show that conditioning the generation on topic models makes generated responses more relevant to the document content.
Functional insights into the Shigella type III needle tip IpaD in secretion control and cell contact

Type III secretion apparatus (T3SA) are complex nanomachines that insert a translocation pore into the host cell membrane through which effector proteins are injected into the cytosol. In Shigella, the pore is inserted by a needle tip complex that also controls secretion. IpaD is the key protein that rules the composition of the tip complex before and upon cell contact or Congo red (CR) induction. However, how IpaD is involved in secretion control and translocon insertion remains not fully understood. Here, we report the phenotypic analysis of 20 10‐amino acids deletion variants all along the coiled‐coil and the central domains of IpaD (residues 131–332). Our results highlight three classes of T3S phenotype; (i) wild‐type secretion, (ii) constitutive secretion of all classes of effectors, and (iii) constitutive secretion of translocators and early effectors, but not of late effectors. Our data also suggest that the composition of the tip complex defines both the T3SA inducibility state and late effectors secretion. Finally, we shed light on a new aspect regarding the contact of the needle tip with cell membrane by uncoupling the Shigella abilities to escape macrophage vacuole, and to insert the translocation pore or to invade non‐phagocytic cells.