Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunological Characterization of the Teleost Adipose Tissue and Its Modulation in Response to Viral Infection and Fat-Content in the Diet

The immune response of the adipose tissue (AT) has been neglected in most animal models until recently, when the observations made in human and mice linking obesity to chronic inflammation and diabetes highlighted an important immune component of this tissue. In the current study, we have immunologically characterized the AT for the first time in teleosts. We have analyzed the capacity of rainbow trout (Oncorhynchus mykiss) AT to produce different immune mediators and we have identified the presence of local populations of B lymphocytes expressing IgM, IgD or IgT, CD8α+ cells and cells expressing major histocompatibility complex II (MHC-II). Because trout AT retained antigens from the peritoneal cavity, we analyzed the effects of intraperitoneal infection with viral hemorrhagic septicemia virus (VHSV) on AT functionality. A wide range of secreted immune factors were modulated within the AT in response to VHSV. Furthermore, the viral infection provoked a significant decrease in the number of IgM+ cells which, along with an increased secretion of IgM in the tissue, suggested a differentiation of B cells into plasmablasts. The virus also increased the number of CD8α+ cells in the AT. Finally, when a fat-enriched diet was fed to the fish, a significant modulation of immune gene expression in the AT was also observed. Thus, we have demonstrated for the first time in teleost that the AT functions as a relevant immune tissue; responsive to peritoneal viral infections and that this immune response can be modulated by the fat-content in the diet.
Beyond resources: Formal models of complexity effects and age differences in working memory

We explore several alternative formal models of working memory capacity limits and of the effect of ageing on these capacity limits. Three models test variations of resource accounts, one assumes a fixed number of free slots in working memory, one is based on decay and processing speed, one attributes capacity limits to interference, and one to crosstalk between associations of content and context representations. The models are evaluated by fitting them to time–accuracy functions of 16 young and 17 old adults working on a numerical memory-updating task under varied memory-load conditions. With increasing complexity (i.e., memory load), both asymptotic accuracy and the rate of approach to the asymptote decreased. Old adults reached lower asymptotes with the more complex tasks, and had generally slower rates. The interference model and the decay model fit the individual time–accuracy functions reasonably well, whereas the other models failed to account for the data. Within the interference model, age effects could be attributed to the older adults' higher susceptibility to interference. Within the decay model, old adults differed from young adults by a higher degree of variability in the activation of working memory contents.
Cost Effectiveness of a Novel Attempt to Reduce Readmission after Ileostomy Creation

Background and Objectives: Dehydration is a common complication after ileostomy creation and is the most frequent reason for postoperative readmission to the hospital. We sought to determine the clinical and economic impact of an outpatient intervention to decrease readmissions for dehydration after ileostomy creation. Methods: All new ileostomates from 09/2011 through 10/2012 at the University of Florida were enrolled to receive an ileostomy education and management protocol and a daily telephone call for 3 weeks after discharge. Counseling and medication adjustments were provided, with a satisfaction survey at the end. Outcomes of these patients were compared to those in a historical control cohort. A cost analysis was conducted to calculate the savings to the hospital. Results: Thirty-eight patients were enrolled. All patients required telephone counseling, and the mean satisfaction score rating was 4.69, on a scale of 1 to 5. The readmission rate for dehydration within 30 days of discharge decreased significantly from 65% before intervention to 16% (5/32 patients) after intervention (P = .002). The length of readmission hospital stay decreased from a mean of 4.2 days before the introduction of the intervention to 3 days after. Cost analysis revealed that the actual total hospital cost of dehydration-specific readmission decreased from $88,858 to $25,037, a saving of $63,821. Conclusion: A standardized ileostomy pathway with comprehensive patient education and outpatient telephone follow-up is cost effective, has a positive influence on patient satisfaction, and reduces dehydration-related readmission rates.
Longitudinal study of wind-up responses after graded spinal cord injuries in the adult rat.

PURPOSE The main objectives of this work were to evaluate the development of neuropathic pain after spinal cord injuries of different severities, and to assess changes in central excitability and plasticity by means of wind-up responses and withdrawal reflexes. METHODS Two groups of rats were subjected to spinal cord contusion with forces of 100 or 200 kdyn applied at T8. Measurements of thermal and mechanical pain thresholds as well as wind-up measurements were performed weekly during two months after injury. Withdrawal reflexes were also assessed electrophysiologically. RESULTS We found that animals with contusion of different severities showed a similar reduction in nociceptive thresholds. All contused animals showed increased wind-up responses compared to intact animals during the first 2 to 6 weeks post injury. The mean increase of wind-up was higher in rats with stronger spinal cord contusion. Results from the withdrawal reflexes did not correlate with nociceptive behaviors nor wind-up responses, highlighting the plasticity of spinal circuits modulation after SCI. CONCLUSION These results indicate that the graded-force spinal cord contusion model is suitable for studying central neuropathic pain, and for assessing changes in wind-up responses. Wind-up measurements can be used as a non-invasive technique to detect changes in central excitability after SCI of different severities.
General Statement on Evaluation

In perceiving the appropriate place of evaluation in modern education, consideration must be given to the purposes which a program of evaluation may serve. At present the purposes most commonly emphasized in schools and colleges are the grading of students, their grouping and promotion, reports to parents, and financial reports to the board of education or to the board of trustees. A comprehensive program of evaluation should serve a broader range of purposes than these. One important purpose of evaluation is to make a periodic check on the effectiveness of the educational institution, and thus to indicate the points at which improvements in the program are necessary. Another important purpose of evaluation which is frequently not recog nized is to validate the hypotheses upon which the educational institution operates. A school or college organizes its curriculum on the basis of a plan which seems to the staff to be satisfactory, but in reality we do not yet know enough about curriculum construction to be sure that a given plan will work satisfactorily in a particular community. On that account, the curriculum of each school or college is based upon hypotheses, that is, the best judgments the staff can make on the basis of information it has. In some cases these hypotheses are not valid, and the educational institution 492
A scheduling and pipelining algorithm for hardware/software systems

Given a hardware/software-partitioned specification and an allocation (number and type) of processors, we present an algorithm to (1) map each of the software behaviors (or tasks) to processors, (2) pipeline the system specification, and (3) schedule the behaviors in each pipe stage amongst selected hardware components and processors, so as to satisfy a throughput constraint at minimal hardware cost. Thus, to achieve high performance, not only are critical tasks implemented as pipelined hardware architectures, but the system is also divided into concurrently executing stages. Furthermore, to offset the cost of this increased concurrency, non-critical sections are implemented on processors or as cheaper hardware blocks. Our experiments demonstrate the feasibility of our approach and the necessity of system pipelining in high-performance design.
Diagnostic Performance of a 10-Minute Gadolinium-Enhanced Brain MRI Protocol Compared with the Standard Clinical Protocol for Detection of Intracranial Enhancing Lesions

A total of 53 patients underwent MR imaging consisting of 5 basic fast precontrast sequences plus standard and accelerated versions of the same postcontrast T1WI sequences. Two neuroradiologists assessed the image quality and the final diagnosis for each set of postcontrast sequences and compared their performances. The 10-minute brain MR imaging protocol with contrast was comparable in diagnostic performance with the standard protocol in an inpatient motion-prone population, with the additional benefits of reducing acquisition times and image artifacts. BACKGROUND AND PURPOSE: The development of new MR imaging scanners with stronger gradients and improvement in coil technology, allied with emerging fast imaging techniques, has allowed a substantial reduction in MR imaging scan times. Our goal was to develop a 10-minute gadolinium-enhanced brain MR imaging protocol with accelerated sequences and to evaluate its diagnostic performance compared with the standard clinical protocol. MATERIALS AND METHODS: Fifty-three patients referred for brain MR imaging with contrast were scanned with a 3T scanner. Each MR image consisted of 5 basic fast precontrast sequences plus standard and accelerated versions of the same postcontrast T1WI sequences. Two neuroradiologists assessed the image quality and the final diagnosis for each set of postcontrast sequences and compared their performances. RESULTS: The acquisition time of the combined accelerated pre- and postcontrast sequences was 10 minutes and 15 seconds; and of the fast postcontrast sequences, 3 minutes and 36 seconds, 46% of the standard sequences. The 10-minute postcontrast axial T1WI had fewer image artifacts (P < .001) and better overall diagnostic quality (P < .001). Although the 10-minute MPRAGE sequence showed a tendency to have more artifacts than the standard sequence (P = .08), the overall diagnostic quality was similar (P = .66). Moreover, there was no statistically significant difference in the diagnostic performance between the protocols. The sensitivity, specificity, and accuracy values for the 10-minute protocol were 100.0%, 88.9%, and 98.1%. CONCLUSIONS: The 10-minute brain MR imaging protocol with contrast is comparable in diagnostic performance with the standard protocol in an inpatient motion-prone population, with the additional benefits of reducing acquisition times and image artifacts.
Aquaporin‐3 gene and protein expression in sun‐protected human skin decreases with skin ageing

Backgroud/Objectives: Aquaporin 3 (AQP3) is a protein implicated in skin hydration. AQP3 null mice have relatively dry skin, reduced skin elasticity, and delayed recovery of barrier function after removal of the stratum corneum which is also present in skin of old people. A feature of skin aging is the change in both water content and barrier function of the skin. We investigated the expression of aquaporin 3 in non sun‐exposed human skin, normal human keratinocytes and fibroblasts from different age groups to further understand the relationship between AQP3 and intrinsic skin aging.
Effects of person and situation expectations on explanation seeking and causal attributions

To examine the effects of person and situation expectations on explanation seeking and causal attributions, subjects in the present experiment observed a situation-expected or -unexpected negative act which was person-expected or -unexpected. The results indicated that explanation seeking was instigated by violations of person and situation expectations although the former exerted little influence when the behaviour was situation-unexpected. In addition, regardless of situation expectations, behaviour which confirmed a person expectation was attributed to the actor's dispositions, whereas behaviour which disconfirmed a person expectation was attributed more to the situation. The latter attribution, however, appears to be a provisional judgement which is made pending additional information which would enable a more confident judgement. The results are discussed in relation to the existing models of the attribution process.
MAGAN: Margin Adaptation for Generative Adversarial Networks

We propose the Margin Adaptation for Generative Adversarial Networks (MAGANs) algorithm, a novel training procedure for GANs to improve stability and performance by using an adaptive hinge loss function. We estimate the appropriate hinge loss margin with the expected energy of the target distribution, and derive principled criteria for when to update the margin. We prove that our method converges to its global optimum under certain assumptions. Evaluated on the task of unsupervised image generation, the proposed training procedure is simple yet robust on a diverse set of data, and achieves qualitative and quantitative improvements compared to the state-of-the-art.
Personality and Political Recruitment: Actualization or Compensation?

Summary Two hypotheses have been offered relating self-concept and political participation. The actualization hypothesis predicts that individuals with a positive self-concept will most often be found among the politically active, while the compensation hypothesis states that those with poor self-concepts participate at high rates to overcome their low estimates of self-esteem. These hypotheses are tested using data from a sample of party activists. Three measures of self-esteem are related to office-seeking. Office-seekers differed from nonoffice-seekers on only one of the self-esteem measures. The actualization hypothesis was partially supported.
Variables influencing teachers' decisions to refer children for school psychological assessment services

The present study examined the variables influencing a teacher's decision to refer children suspected of having developmental or behavioral problems. Results indicated that younger children were not referred at a disproportionate rate for school psychological services as compared to their older classmates as suggested by earlier research, height and weight acted as moderator variables with respect to teacher referral patterns, African American children were referred at a disproportionate rate for developmental handicap services than were Caucasian children, and males were referred more than females for behavioral problems. These findings are discussed in terms of attribution and expectancy theories. © 1997 John Wiley & Sons, Inc.
Assessing the living and dead proportions of cold-water coral colonies: implications for deep-water Marine Protected Area monitoring in a changing ocean

Coral growth patterns result from an interplay of coral biology and environmental conditions. In this study colony size and proportion of live and dead skeletons in the cold-water coral (CWC) Lophelia pertusa (Linnaeus, 1758) were measured using video footage from Remotely Operated Vehicle (ROV) transects conducted at the inshore Mingulay Reef Complex (MRC) and at the offshore PISCES site (Rockall Bank) in the NE Atlantic. The main goal of this paper was to explore the development of a simple method to quantify coral growth and its potential application as an assessment tool of the health of these remote habitats. Eighteen colonies were selected and whole colony and dead/living layer size were measured. Live to dead layer ratios for each colony were then determined and analysed. The age of each colony was estimated using previously published data. Our paper shows that: (1) two distinct morphotypes can be described: at the MRC, colonies displayed a ‘cauliflower-shaped’ morphotype whereas at the PISCES site, colonies presented a more flattened ‘bush-shaped’ morphotype; (2) living layer size was positively correlated with whole colony size; (3) live to dead layer ratio was negatively correlated to whole colony size; (4) live to dead layer ratio never exceeded 0.27. These results suggest that as a colony develops and its growth rate slows down, the proportion of living polyps in the colony decreases. Furthermore, at least 73% of L. pertusa colonies are composed of exposed dead coral skeleton, vulnerable to ocean acidification and the associated shallowing of the aragonite saturation horizon, with significant implications for future deep-sea reef framework integrity. The clear visual contrast between white/pale living and grey/dark dead portions of the colonies also gives a new way by which they can be visually monitored over time. The increased use of marine autonomous survey vehicles offers an important new platform from which such a surveying technique could be applied to monitor deep-water marine protected areas in the future.
Therapy for auditory processing impairment in aphasia: An evaluation of two approaches

Aims: This study evaluated two forms of discrimination therapy for auditory processing impairment in aphasia. It aimed to determine whether therapy can improve speech perception and/or help participants use semantic information to compensate for their impairment. Changes in listening were also explored by recording the level of facilitation needed during therapy tasks. Finally the study examined the effect of therapy on an everyday listening activity: a telephone message task. Method: The study employed a repeated measures design. Eight participants received 12 sessions each of phonological and semantic–phonological therapy. Both programmes used minimal pair judgement tasks, but the latter embedded such tasks within a meaningful context, so encouraged the strategic use of semantic information (semantic bootstrapping). Experimental measures of auditory discrimination and comprehension were administered twice before therapy, once after each programme, and again six weeks later. The telephone message task was also administered at each time point. Test data were subjected to both group and individual analyses. Records of progress during therapy (i.e., changes in support needed to carry out therapy tasks) were completed during treatment and analysed across the group. Results: Group analyses showed no significant changes in tests of word and nonword discrimination as a result of therapy. One comprehension task improved following therapy, but two did not. There was also no indication that therapy improved the discrimination of treated words, as assessed by a priming task. The facilitation scores indicated that participants needed less support during tasks as therapy progressed, possibly as a result of improved listening. There was a significant effect of time on the telephone message task. Across all tasks there were few individual gains. Conclusions: The results offer little evidence that therapy improved participants’ discrimination or semantic bootstrapping skills. Some changes in listening may have occurred, as indicated by the facilitation scores. Reasons for the null findings are discussed.
Exodus-1 (CCL20): evidence for the participation of this chemokine in spontaneous labor at term, preterm labor, and intrauterine infection.

AIM CCL20, also known as MIP-3 alpha, is a chemokine that participates in chemotaxis of immature dendritic cells, effector/memory T-cells, and B-lymphocytes. The objectives of this study were to determine whether CCL20 can be detected in amniotic fluid (AF) and if AF concentration of this chemokine changes with advancing gestational age, parturition (term and preterm), and intra-amniotic infection/inflammation (IAI). METHODS A cross-sectional study was conducted including the following groups: (1) mid-trimester of pregnancy (n=65); (2) term not in labor (TNL; n=22); (3) term in labor (TIL; n=47); (4) spontaneous preterm labor (PTL) who delivered at term (n=57); (5) spontaneous PTL without IAI who delivered preterm (n=71); and (6) spontaneous PTL with IAI (n=38). AF CCL20 concentrations were determined using ELISA. RESULTS (1) The median AF CCL20 concentration in TNL was higher than that of mid-trimester patients; (2) Women in spontaneous labor at term had a higher median AF concentration of CCL20 than patients at term not in labor; (3) Patients with spontaneous PTL and IAI had a significantly higher median AF concentration of CCL20 than those without IAI who delivered preterm and those who delivered at term. Moreover, women with spontaneous PTL without IAI who delivered preterm had a significantly higher median AF concentration than those with PTL who subsequently delivered at term. CONCLUSIONS (1) CCL20 is a physiologic constituent of AF and its concentration increases as term approaches; (2) spontaneous labor (term and preterm) in the absence of IAI is associated with increased bioavailability of AF CCL20 suggesting that an increase in CCL20 is part of the common pathway of human parturition; (3) patients with IAI had dramatic elevations in the AF CCL20 concentrations suggesting that this chemokine participates in the host response to infection or other stimuli associated with intra-amniotic infection.
A longitudinal examination of the relationship between teacher burnout and depression

This study investigates the longitudinal relationships between burnout and depression among teachers. Middle and high school teachers participated in a 3-wave survey. The results of the latent growth modeling analysis revealed that there was a significant relationship between the initial status of burnout and the initial status of depression. Results also indicated a significant relationship between the change rate of burnout and the change rate of depression. Moreover, the autoregressive cross-lagged modeling revealed a causal relationship such that teacher's burnout leads to subsequent depression symptoms, not vice versa.
The case for using Bridge Certificate Authorities for Grid computing

As Grid deployments increase, the challenge remains to create a scalable, multi‐organizational authentication infrastructure. Public key infrastructures (PKIs) are widely used for authentication in Grids, due in large part to the success of the Globus toolkit, despite the challenges and difficulties both for PKI administrators and users. The Bridge Certificate Authority (CA) is a compromise between a strictly hierarchical PKI and a mesh PKI and achieves many of the benefits of the hierarchical PKI and mesh PKI but has been untested for use with Grid software. This paper reports on the use of a Bridge CA with two representative Grid software packages: the Globus Toolkit v2 and WSRF.NET. We find that both packages support Bridge CAs sufficiently today to be usable in Grid software architectures, although not without limitations. In this paper, and through these experiments, we build the case for using Bridge CAs for Grid computing. Copyright © 2005 John Wiley & Sons, Ltd.
Some Influences on Regional Variation in Frequency of Prescription of Electroconvulsive Therapy

A Republic of Ireland national survey of electroconvulsive therapy (ECT) showed wide inter-hospital variation in ECT rates. Psychiatric admission rates, professional attitudes, and patient turnover were found to predict these rates. No significant association was found between ECT rates and public/private care or other socio-economic factors. A limited examination of British admission data revealed a similar set of correlations, suggesting that the findings may apply in non-profit health-care systems outside the Republic of Ireland.