Miracle-dz/UniFAR-FTUs huggingface dataset:
Prostate Cancer Cell Lines under Hypoxia Exhibit Greater Stem-Like Properties

Hypoxia is an important environmental change in many cancers. Hypoxic niches can be occupied by cancer stem/progenitor-like cells that are associated with tumor progression and resistance to radiotherapy and chemotherapy. However, it has not yet been fully elucidated how hypoxia influences the stem-like properties of prostate cancer cells. In this report, we investigated the effects of hypoxia on human prostate cancer cell lines, PC-3 and DU145. In comparison to normoxia (20% O2), 7% O2 induced higher expressions of HIF-1α and HIF-2α, which were associated with upregulation of Oct3/4 and Nanog; 1% O2 induced even greater levels of these factors. The upregulated NANOG mRNA expression in hypoxia was confirmed to be predominantly retrogene NANOGP8. Similar growth rates were observed for cells cultivated under hypoxic and normoxic conditions for 48 hours; however, the colony formation assay revealed that 48 hours of hypoxic pretreatment resulted in the formation of more colonies. Treatment with 1% O2 also extended the G0/G1 stage, resulting in more side population cells, and induced CD44 and ABCG2 expressions. Hypoxia also increased the number of cells positive for ABCG2 expression, which were predominantly found to be CD44bright cells. Correspondingly, the sorted CD44bright cells expressed higher levels of ABCG2, Oct3/4, and Nanog than CD44dim cells, and hypoxic pretreatment significantly increased the expressions of these factors. CD44bright cells under normoxia formed significantly more colonies and spheres compared with the CD44dim cells, and hypoxic pretreatment even increased this effect. Our data indicate that prostate cancer cells under hypoxia possess greater stem-like properties.
Imagery, Affect, and Financial Judgment

Traditional theories of finance posit that the pricing of securities in financial markets should be done according to the quality of their underlying technical fundamentals. However, research on financial markets has tended to indicate that factors other than technical fundamentals are often used by market participants to gauge the value of securities. This phenomenon may be quite prevalent in markets for initial public offerings (IPOs), where securities lack a financial history. The imagery and affect associated with securities can be a powerful basis upon which to judge their worth. Advanced business students in a securities analysis course were asked to evaluate a number of industry groups represented on the New York Stock Exchange in terms of a set of judgmental variables. After providing imagery and affective evaluations for each industry group, the participants judged the likelihood that they would invest in companies associated with each industry. Imagery and affective ratings were highly correlated with one another and with the likelihood of investing. Judgments of performance correlated poorly to moderately with actual market performance as measured by weighted average returns for the industry groups studied. The results suggest that imagery and affect are part of a coherent psychological framework for evaluating classes of securities, but that framework may have low validity for predicting performance.
Meningkatkan Kemampuan Berpikir Kritis Matematis Siswa SMK melalui Model Pembelajaran Berbasis Masalah

Mathematics is a subject that can train students in developing critical thinking, logical, creative, effective and systematic as well as assist in the development of personality and reasoning power of a person. Hopefully, with these capabilities that students can face all kinds of challenges in today's modern era. This study aims to determine the increase in critical thinking skills students acquire mathematical learning with problem based learning model in terms of: (a) the whole student, and (b) the level (high, medium, and low) ability of students. This study uses a quantitative approach with the experimental method. The population in this study are all class XI student of SMK Negeri 5 Banda Aceh and a sample of the research is class XI RPL-1 as an experimental class and class XI RPL-2 as the control class. The data were analyzed with the average gain is normalized between the two classes. The results showed that an increase in the ability of critical thinking mathematical students acquire learning with problem based learning model is singnifikansi better than on the ability of critical thinking mathematical students who received conventional learning when viewed from the overall and by level (high, medium, and low) ability of students.
Chronic Pain and Its Determinants: A Population-based Study in Southern Iran

Background Prevalence of chronic pain and its association with demographic characteristics have been reported by different studies from different geographical regions in the world. However, data from many Middle East countries including Iran (especially southern Iran) are scare. The aim of the present study was to demonstrate the prevalence of chronic pain and its association with demographic, psychological and socioeconomic factors in an Iranian population. Methods In this population-based survey, the target population was comprised of subjects aged 20 to 85 years residing in Jahrom, southern Iran during 2009-2011. All eligible subjects were invited to participate in the study. Before a detailed questionnaire was given; face to face interviews were done for each individual. Results There were 719 men and 874 women with an average age of 40.5 years at the onset of the study. Among the study population, 38.9% (620/1,593) complained of chronic pain, of whom 40.8% (253/620) were men and 59.2% (367/620) were women. Foot and joint pain were observed in 31.9%. Hip and spine pain, migraine and tension headaches, heart pain, and abdomen pain were observed in 21.5%, 15.5%, 9.5%, and 8.0% of chronic pain cases, respectively. There was a significant association among the covariables age, sex, overweight, educational level, income, and type of employment with chronic pain as the dependent variable (P < 0.0001). Conclusions Our findings show the prevalence of chronic pain and its association with demographic, psychological and socioeconomic factors. Individuals with low incomes and less education became accustomed to pain due to a lack of knowledge.
Sources of Self-Efficacy as Predictors of EFL Learners’ Course Performance

It is generally believed that self-efficacy as a psychological construct contributes to learning process and academic performance. The present study attempted to investigate the possible differences among self-efficacy sources as predictors of EFL learners’ academic achievement in educational settings. To this end, a questionnaire of EFL self-efficacy sources together with Nelson English Proficiency Test were administered among 219 senior EFL learners. The collected data were analyzed using multiple regression analysis. The results indicated that of the four sources of self-efficacy, only enactive mastery experience accounted for a statistically significant portion of the variance with course performance and, therefore, was a positive predictor of students’ course performance. The results of the present study imply that when learners continue to develop self-efficacy, they will have better English performance scores. It is also concluded that what an educational system needs to consider, in addition to general teaching and learning process, is focusing on personality features of learners. The findings of this study can, therefore, provide implications for researchers, teachers, materials developers, and syllabus designers.
A Bispecific Antibody Based Assay Shows Potential for Detecting Tuberculosis in Resource Constrained Laboratory Settings

The re-emergence of tuberculosis (TB) as a global public health threat highlights the necessity of rapid, simple and inexpensive point-of-care detection of the disease. Early diagnosis of TB is vital not only for preventing the spread of the disease but also for timely initiation of treatment. The later in turn will reduce the possible emergence of multi-drug resistant strains of Mycobacterium tuberculosis. Lipoarabinomannan (LAM) is an important non-protein antigen of the bacterial cell wall, which is found to be present in different body fluids of infected patients including blood, urine and sputum. We have developed a bispecific monoclonal antibody with predetermined specificities towards the LAM antigen and a reporter molecule horseradish peroxidase (HRPO). The developed antibody was subsequently used to design a simple low cost immunoswab based assay to detect LAM antigen. The limit of detection for spiked synthetic LAM was found to be 5.0 ng/ml (bovine urine), 0.5 ng/ml (rabbit serum) and 0.005 ng/ml (saline) and that for bacterial LAM from M. tuberculosis H37Rv was found to be 0.5 ng/ml (rabbit serum). The assay was evaluated with 21 stored clinical serum samples (14 were positive and 7 were negative in terms of anti-LAM titer). In addition, all 14 positive samples were culture positive. The assay showed 100% specificity and 64% sensitivity (95% confidence interval). In addition to good specificity, the end point could be read visually within two hours of sample collection. The reported assay might be used as a rapid tool for detecting TB in resource constrained laboratory settings.
Web personal name disambiguation based on reference entity tables mined from the web

Ambiguous personal names are common on the Web, which pose a challenge for many different tasks. The traditional disambiguation employs the clustering methods. However, without reference entity tables, the clustering method can only identify whether two names refer to the same entity, rather than identify which entities they refer to. Furthermore, clustering methods are difficult to achieve robust performance on different names. Some recent disambiguation methods (the link-with-entity-base methods) extract the reference entity tables from online entity bases. The link-with-entity-base methods, however, suffer from the entity base's limited coverage problem, so it can only disambiguate names in a limited coverage. In this paper, to overcome the previous methods' deficiencies, we propose a web-querying method to mine the reference entity tables from the Web automatically with the help of professional category knowledge. Then, we disambiguate personal names by linking them to the personal entities within the mined tables through categorization. The experimental results on the dataset extracted from Freebase show that our web-querying method can effectively mine personal entity with an F-measure 0.90. The disambiguation results on WePS datasets show that our method can achieve more robust and informative performance than the traditional clustering methods; and outperforms the traditional link-with-entity-base methods with a 0.29 improvement in F-measure.
Passive Intermodulation Due to Self-Heating in Printed Transmission Lines

This paper proposes a mechanism by which third-order intermodulation distortion, due to self-heating, is generated in transmission lines. This work shows how transmission lines made of several materials, whose properties are independent of the electric and magnetic fields, can generate important levels of intermodulation distortion. A circuit model supported by finite-element simulations is presented to account for the temperature generation and also for its impact on the nonlinear performance. Closed-form expressions are used to calculate the generated intermodulation products and are derived from the circuit model and compared with simulations. Finally, measurements and simulations of different transmission lines are presented, showing very good agreement.
Regional Inequalities in Lung Cancer Mortality in Belgium at the Beginning of the 21st Century: The Contribution of Individual and Area-Level Socioeconomic Status and Industrial Exposure

Being a highly industrialized country with one of the highest male lung cancer mortality rates in Europe, Belgium is an interesting study area for lung cancer research. This study investigates geographical patterns in lung cancer mortality in Belgium. More specifically it probes into the contribution of individual as well as area-level characteristics to (sub-district patterns in) lung cancer mortality. Data from the 2001 census linked to register data from 2001–2011 are used, selecting all Belgian inhabitants aged 65+ at time of the census. Individual characteristics include education, housing status and home ownership. Urbanicity, unemployment rate, the percentage employed in mining and the percentage employed in other high-risk industries are included as sub-district characteristics. Regional variation in lung cancer mortality at sub-district level is estimated using directly age-standardized mortality rates. The association between lung cancer mortality and individual and area characteristics, and their impact on the variation of sub-district level is estimated using multilevel Poisson models. Significant sub-district variations in lung cancer mortality are observed. Individual characteristics explain a small share of this variation, while a large share is explained by sub-district characteristics. Individuals with a low socioeconomic status experience a higher lung cancer mortality risk. Among women, an association with lung cancer mortality is found for the sub-district characteristics urbanicity and unemployment rate, while for men lung cancer mortality was associated with the percentage employed in mining. Not just individual characteristics, but also area characteristics are thus important determinants of (regional differences in) lung cancer mortality.
Using Auditory Modalities to Develop Rhythmic Competency in Children's Fundamental Movement Skills

Using Auditory Modalities to Develop Rhythmic Competency in Children‟s Fundamental Movement Skills by Sally Suzanne Severy MS, West Virginia University, 1995 BS, West Virginia University, 1994 Doctoral Study Submitted in Fulfillment of the Requirements for the Degree of Doctor of Education Walden University October 2016 Abstract Physical education classrooms often have low levels of moderate to vigorous physical activity levels. This is a problem since many young elementary students are not building a foundation of fundamental movement skills necessary to be lifelong participants in physical activities. This study investigated how elementary physical education teachers used auditory modalities in their classrooms. The research question explored thePhysical education classrooms often have low levels of moderate to vigorous physical activity levels. This is a problem since many young elementary students are not building a foundation of fundamental movement skills necessary to be lifelong participants in physical activities. This study investigated how elementary physical education teachers used auditory modalities in their classrooms. The research question explored the emergence of rhythmic competency in fundamental movement skills to increase overall moderate to vigorous activity levels. This concurrent, mixed-methods, multiple case study used a constructivist paradigm using the schema and dynamic system theories as the underlying motor system theoretical framework. Two research sites were selected: a suburban Maryland public school system and a private liberal arts college located in the same county. The participants included 21 elementary physical education teachers and 6 physical education or exercise science majors from nationally recognized programs. Data were collected from a focus group, interviews, classroom observations, and a 10-item response Likert style survey designed for elementary physical education teachers to recognize current trends in the field of auditory modalities and rhythmic competency. The data were analyzed to identify auditory modality instructional methods for the emergence of rhythmic competencies. The results consisted of a list of best practices for use such as musical rhythms, verbal cues, and sound cues by physical education teachers and specialists. This research promotes positive social change by providing information for successfully planning interventions in the discipline of motor skill and rhythmic development that can lead to overall increased more-vigorous physical activity. Using Auditory Modalities to Develop Rhythmic Competency in Children‟s Fundamental Movement Skills by Sally Suzanne Severy MS, West Virginia University, 1995 BS, West Virginia University, 1994 Doctoral Study Submitted in Fulfillment of the Requirements for the Degree of
The Historical Development of Japanese Investment in Malaysia (1910-2003)

This article discusses the historical development of Japanese investment in Malaysia between the years 1991 and 2003. When Tun Dr. Mahathir Mohamad took over the administration, Japanese investment in the country has been growing rapidly as Japan emerged as the largest trading partner of Malaysia. The consequence of crisis with the British government witness by 1982 Japan’s position in Malaysia has further strengthened through the implementation of the Look East Policy. Through this policy, the Japanese management system and work ethic has been widely publicized to continue the pro-Japanese orientation. Tun Dr. Mahathir Mohamad is responsible in projecting a more positive image of Japan in the 1980s and 1990s. The focus on domestic economic growth with focus on industrial, multi-ethnic community tolerance as well as political stability becomes Malaysia’s foreign policy throughout the administration of Tun Dr Mahathir Mohamad to attract Japanese investment. Although researcher found too many previous studies on Japanese investment in Malaysia, this research will be able to complement previous studies through the collection of the characteristics of Japanese investment in Malaysia during this period for other researchers’ guidance. This study will also collect data from different sources from previous researchers. The different data will also provide new insight to the reader about the history of Japanese investments in this period.
A Linked-Data Model for Semantic Sensor Streams

This paper describes a semantic modelling scheme, a naming convention and a data distribution mechanism for sensor streams. The proposed solutions address important challenges to deal with large-scale sensor data emerging from the Internet of Things resources. While there are significant numbers of recent work on semantic sensor networks, semantic annotation and representation frameworks, there has been less focus on creating efficient and flexible schemes to describe the sensor streams and the observation and measurement data provided via these streams and to name and resolve the requests to these data. We present our semantic model to describe the sensor streams, demonstrate an annotation and data distribution framework and evaluate our solutions with a set of sample datasets. The results show that our proposed solutions can scale for large number of sensor streams with different types of data and various attributes.
Reference Cluster Normalization Improves Detection of Frontotemporal Lobar Degeneration by Means of FDG-PET

Positron emission tomography with [18F] fluorodeoxyglucose (FDG-PET) plays a well-established role in assisting early detection of frontotemporal lobar degeneration (FTLD). Here, we examined the impact of intensity normalization to different reference areas on accuracy of FDG-PET to discriminate between patients with mild FTLD and healthy elderly subjects. FDG-PET was conducted at two centers using different acquisition protocols: 41 FTLD patients and 42 controls were studied at center 1, 11 FTLD patients and 13 controls were studied at center 2. All PET images were intensity normalized to the cerebellum, primary sensorimotor cortex (SMC), cerebral global mean (CGM), and a reference cluster with most preserved FDG uptake in the aforementioned patients group of center 1. Metabolic deficits in the patient group at center 1 appeared 1.5, 3.6, and 4.6 times greater in spatial extent, when tracer uptake was normalized to the reference cluster rather than to the cerebellum, SMC, and CGM, respectively. Logistic regression analyses based on normalized values from FTLD-typical regions showed that at center 1, cerebellar, SMC, CGM, and cluster normalizations differentiated patients from controls with accuracies of 86%, 76%, 75% and 90%, respectively. A similar order of effects was found at center 2. Cluster normalization leads to a significant increase of statistical power in detecting early FTLD-associated metabolic deficits. The established FTLD-specific cluster can be used to improve detection of FTLD on a single case basis at independent centers – a decisive step towards early diagnosis and prediction of FTLD syndromes enabling specific therapies in the future.
ATTITUDES OF EFL LEARNERS TOWARDS THE INTERNET

Related literature indicates that the Internet has an important role and great potential in foreign language learning. It is also obvious that attitudes of learners affect learning process significantly. This study aimed to investigate the attitudes of foreign language learners and to find the relationship between attitudes and subject variables. A background questionnaire, a test on Internet information and a survey were administered to 115 foreign language learners. Data gathered were analyzed statistically. The results showed that EFL learners had positive attitudes towards the Internet except some items such as addiction, socialization and shopping. It was implicated that positive attitudes would contribute to foreign language learning via the Internet after overcoming some potential problems and disadvantages.
Non-LTE Calculation for the Be Star Decretion Disk

The non-LTE state of the hydrogen gas in isothermal transonic decretion disks around a B1V star has been calculated by an iterative method in order to explore the basic physical process in the disk. This dynamical model is characterized by a density law in the equatorial plane of ρ(R) ∝ R −3.5 . The continuous radiation is calculated with theiteration in the integral form, while we adopt a single-flight escape probability for lines. We describe the non-LTE state, the radiation flow and conversion in the disk. We conclude that the stellar Balmer continuum plays a key role in the non-LTE state of the disk. The examination of the local energy gain and loss suggests that the disk temperature has double minima along the equatorial plane in the optically thick case: the intermediate region caused by deficient ultraviolet radiation and the outer Lyman α cooling region. We have also calculated some observable quantities, such as the spectral energy distribution, the UBV colors, the infrared excess and the Balmer line profiles. Our calculations with the mass loss rate less than 10 −10 M⊙ yr −1 reproduce the observed continuum quantities. However, we could not get large Hα emission strength observed in Be stars. We suggest that the density gradient of the Be star disk is slower than that of the isothermal decretion disk.