Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing socio-economic vulnerability to climate change impacts and environmental hazards in New South Wales and Queensland, Australia.

This article systematically reviews and synthesises academic, peer-reviewed literature to assess the state of knowledge concerning socio-economic vulnerability to climate change impacts and environmental hazards in New South Wales and Queensland, Australia. It focuses upon empirical research that identifies socio-economic factors associated with vulnerable subpopulations. Using systematic review methods, 35 articles met the inclusion criteria. These articles are analysed according to their general characteristics, the methods used, and the factors reported to be associated with socio-economic vulnerability. This body of evidence reveals that (1) the majority of the knowledge about socio-economic vulnerability in New South Wales and Queensland has only recently emerged; (2) more knowledge has been published about Queensland; and (3) extreme temperature is the most researched environmental hazard. Despite increased research activity over time, the number of factors repeatedly demonstrated to influence socio-economic vulnerability is small. Age, gender, place of residence, and pre-existing illness were the most commonly reported factors, although the influence of these factors upon socio-economic vulnerability is complex. There is scope to extend the empirical research base across a broader range of climate-related hazards and to better link findings from the domains of climate change vulnerability and population health.
Signs of dysarthria in adults with 22q11.2 deletion syndrome

The aim of the study was to investigate how adults with 22q11.2 deletion syndrome (22q11DS) performed on dysarthria and intelligibility tests compared with a control group. Ten participants with confirmed 22q11.2 deletion, five males and five females with a mean age of 31 years (range: 19–49), were compared with a control group matched for gender and age (five males and five females, mean age: 32 years, range: 19–49). Assessment of non‐verbal and verbal tasks reflecting respiration, phonation, oral motor function, velopharyngeal function, articulation, and prosody was performed as well as the Swedish Test of Intelligibility (STI). All assessments were made by two raters; inter‐rater and intra‐rater reliability was acceptable. The participants with 22q11DS had significantly more problems than the control group on all investigated dimensions except the STI. Overall, the severity of their speech deviation was rated as mild to moderate. The largest difficulties were found regarding speech respiration, phonation, oral motor function, and velopharyngeal function. The results of the present study suggest that a neurological etiology could be added to the previously described structural etiology explaining the speech difficulties found in 22q11DS. Signs of difficulties in both speech motor planning and speech motor programming were found. Further studies are needed to confirm the results, as are studies of the association between structural brain abnormalities and neurological speech symptoms. For clinical purposes, it is important that clinicians have knowledge about the variable speech symptoms that may occur in individuals with 22q11DS and that they be aware of the complexity of the etiology of such speech symptoms. © 2017 Wiley Periodicals, Inc.
A longitudinal study of self-efficacy and depressive symptoms in youth of a North American Plains tribe1

Abstract We used a 3-year cross-sequential longitudinal design to examine the relations between self-efficacy judgments in three different domains (academic, social, resisting negative peer influences), cultural identity, theories of intelligence, and depressive symptoms. One hundred ninety-eight American Indian youths participated in the study, who all attended a middle school on a reservation in the northern plains of the United States. We conducted multilevel models to examine both between- and within-person associations as well as to investigate lagged within-youth associations. We found that not only did youths with relatively high self-efficacy have lower depressive symptom levels than other youths, but also increases in efficacy beliefs for academic, social, and for resisting negative peer influences predicted decreases in depressive symptoms within youths, even after controlling for previous levels of depressive symptoms as well as both contemporaneous and previous academic achievement. Neither cultural identity nor theories of intelligence moderated the relationship between self-efficacy and depression. As the first evidence that within-youth improvements in self-efficacy has developmental benefits, our findings help fill a long empty niche in the line of studies investigating the impact of efficacy beliefs on depressive symptoms.
A Model for Sedimentation by Tidewater Glaciers

Sampling of sediment from the fjord floor in front of tidewater glaciers in Glacier Bay, Alaska, has provided information about processes in this restricted glacimarine (Dreimanis 1979) setting. Sediment sampling, in conjunction with oceanographic and glacial dynamics data, has also enabled the discrimination of sediment types and their facies associations. Deposits are strongly controlled by: sea-water characteristics, position and sediment discharge of melt-water streams, iceberg calving, and rate of glacierfront retreat. Five distinct facies associations have been found to reflect glacier-fjord regimes. The facies associations and ice-fjord conditions responsible for them form the basis for constructing a preliminary model for glacimarine sedimentation by tidewater glaciers. The model can be used to predict (i) rapid retreat of an actively calving ice front, (ii) slow retreat or stabilization of a calving ice front at a channel constriction, (iii) stabilization of a melting (very rarely calving) ice front when the glacier base is near tidewater elevation, and (iv) large outwash delta progradation into a fjord when the ice front retreats onto land. This model can be used to interpret facies associations found in a stratigraphic record.
Transvenous Implantable Cardioverter-Defibrillator Lead Reliability: Implications for Postmarket Surveillance

Background As implantable cardioverter-defibrillator technology evolves, clinicians and patients need reliable performance data on current transvenous implantable cardioverter-defibrillator systems. In addition, real-world reliability data could inform postmarket surveillance strategies directed by regulators and manufacturers. Methods and Results We evaluated Medtronic Sprint Quattro, Boston Scientific Endotak, and St Jude Medical Durata and Riata ST Optim leads implanted by participating center physicians between January 1, 2006 and September 1, 2012. Our analytic sample of 2653 patients (median age 65, male 73%) included 445 St Jude, 1819 Medtronic, and 389 Boston Scientific leads. After a median of 3.2 years, lead failure was 0.28% per year (95% CI, 0.19 to 0.43), with no statistically significant difference among manufacturers. Simulations based on these results suggest that detecting performance differences among generally safe leads would require nearly 10 000 patients or very long follow-up. Conclusions Currently marketed implantable cardioverter-defibrillator leads rarely fail, which may be reassuring to clinicians advising patients about risks and benefits of transvenous implantable cardioverter-defibrillator systems. Regulators should consider the sample size implications when designing comparative effectiveness studies and evaluating new technology for preventing sudden cardiac death.
Mental Training Affects Distribution of Limited Brain Resources

The information processing capacity of the human mind is limited, as is evidenced by the so-called “attentional-blink” deficit: When two targets (T1 and T2) embedded in a rapid stream of events are presented in close temporal proximity, the second target is often not seen. This deficit is believed to result from competition between the two targets for limited attentional resources. Here we show, using performance in an attentional-blink task and scalp-recorded brain potentials, that meditation, or mental training, affects the distribution of limited brain resources. Three months of intensive mental training resulted in a smaller attentional blink and reduced brain-resource allocation to the first target, as reflected by a smaller T1-elicited P3b, a brain-potential index of resource allocation. Furthermore, those individuals that showed the largest decrease in brain-resource allocation to T1 generally showed the greatest reduction in attentional-blink size. These observations provide novel support for the view that the ability to accurately identify T2 depends upon the efficient deployment of resources to T1. The results also demonstrate that mental training can result in increased control over the distribution of limited brain resources. Our study supports the idea that plasticity in brain and mental function exists throughout life and illustrates the usefulness of systematic mental training in the study of the human mind.
Paradoxical lessening of autoimmune processes in non‐obese diabetic mice afterinfection with the diabetogenic variant of encephalomyocarditis virus

In order to gain insight into the interaction between autoimmunity and viral infection in the onset of insulin‐dependent diabetes, non‐obese diabetic (NOD) micewhich spontaneously develop autoimmune diabetes were inoculated with the diabetogenic variant of the encephalomyocarditis virus (EMCV‐D) before the onset of the disease. The pre‐diabetic period was divided into two phases: the early phase (days 88 to 116) during which development of spontaneous diabetes is rare and the late phase (day 123 to 200) during which the incidence of spontaneous diabetes is high. As controls ICR mice of common ancestry were also inoculated. During the early phase diabetes was observed in 4/10 inoculated, 0/13 control NOD and 7/13 inoculated ICR males vs. 6/12 inoculated, 1/11 control NOD and 0/15 inoculated ICR females. However, in NOD female, virus‐induced diabetes prevalence was variable from one experiment to another. In parallel the flow cytometric analysis showed a high percentage of L3T4+ T lymphocytes in the pancreas of inoculated female NOD mice 10 days after the infection. At this time a large proportion of both L3T4+ and Ly‐2+ cells expressed the interleukin 2 receptor. During the late phase no new case of diabetes occurred in inoculated NOD mice but one case was observed in control NOD males and five in control NOD females. This prevention of autoimmune diabetes was constantly found in other experiments. Insulitis was milder in inoculated NOD mice of both sexes than in control NOD. Adoptive transfer of diabetes into irradiated 8‐week‐old males by splenocytes from 28‐week‐old females was successful in five out seven attempts with control splenocytes and in zero out of six attempts with splenocytes from inoculated mice. This immunosuppression was specific as the ability of lymphocytes to respond to soluble or allogeneic antigens was preserved.
Do Rating Agencies Cater? Evidence from Rating-Based Contracts

I examine whether rating agencies cater to borrowers with rating-based performance-priced loan contracts (PPrating firms). I use data from Moody׳s Financial Metrics on its quantitative adjustments for off-balance-sheet debt and qualitative adjustments for soft factors. In the cross-section and for borrowers experiencing adverse economic shocks, I find that these adjustments are more favorable for PPrating firms than for other firms, consistent with rating agencies catering to the PPrating borrowers. I find that this catering is muted in two circumstances when rating agencies׳ reputational costs are higher than usual: (1) near the investment grade and prime short-term rating thresholds and (2) when Fitch Ratings also provides a rating.
Usefulness of transcranial color-coded sonography in the diagnosis of cerebral vasospasm.

BACKGROUND AND PURPOSE The noninvasive diagnosis of cerebral vasospasm with the use of conventional transcranial Doppler ultrasonography (TCD) is based on a velocity study of the middle cerebral artery (MCA). The authors report a prospective comparative study between transcranial color-coded sonography (TCCS), conventional transcranial Doppler (TCD), and angiography in the diagnosis of cerebral vasospasm after surgical treatment for aneurysm. METHODS Thirty consecutive patients underwent routine angiography after surgical treatment for intracranial aneurysm. The distribution of vasospasm was determined after a prospective calculation of the angiographic diameter of the MCA, internal carotid artery (ICA), and anterior cerebral artery (ACA). The blood flow velocities (systolic and maximum) of the MCA, ICA, and ACA were evaluated by TCCS and TCD. RESULTS The correlation between mean maximum velocity and angiographic diameter was significant for the MCA (r=-0.637, P<0.0001), ICA (r=-0.676, P<0.0001), and ACA (r=-0.425, P<0.01). TCCS sensitivity and specificity were higher than those for TCD for MCA (100% and 93%, respectively) and ICA (100% and 96.6%, respectively). For ACA, the sensitivity and specificity were 71.4% and 84.8%, respectively. CONCLUSIONS The authors suggest that TCCS is useful for accurate monitoring of cerebral vasospasm in the MCA and ICA. In the ACA, TCCS monitors the hemodynamic state of the anterior part of the circle of Willis, which could expose the patient to a delayed ischemic deficit.
Hematopoietic growth factors in aplastic anemia patients treated with immunosuppressive therapy-systematic review and meta-analysis

Immunosuppressive therapy is the treatment for aplastic anemia patients ineligible for transplantation. The role of hematopoietic growth factors as adjunct to treatment in these patients is unclear. Findings of this study indicate that the addition of hematopoietic growth factors does not affect mortality, response rate or infections occurrence. Therefore, it should not be recommended routinely as an adjunct to the immunosuppressive therapy for patients with aplastic anemia. Immunosuppressive therapy is the treatment for aplastic anemia patients ineligible for transplantation. The role of hematopoietic growth factors as adjunct to treatment in these patients is unclear. We conducted a systematic review and meta-analysis of randomized controlled trials comparing treatment with immunosuppressive therapy and hematopoietic growth factors to immunosuppressive therapy alone in patients with aplastic anemia. Two reviewers appraised the quality of trials and extracted data. For each trial, results were expressed as relative risks with 95% confidence intervals (CI) for dichotomous data. The addition of hematopoietic growth factors yielded no difference in overall mortality at 100 days, one year and five years [relative risks 1.33 (95% CI 0.56–3.18), relative risks 0.90 (95% CI 0.50–1.63) and relative risks 0.89 (95% CI 0.55–1.46), respectively]. There was no difference in overall hematologic response and in the occurrence of infections. HGF significantly decreased the risk for relapse, relative risks 0.45 (95% CI 0.30–0.68, 3 trials). Hematopoietic growth factors were not associated with higher occurrence of myelodysplastic syndrome and acute myeloid leukemia or paroxysmal nocturnal hemoglobinuria. The addition of hematopoietic growth factors does not affect mortality, response rate or infections occurrence. Therefore, it should not be recommended routinely as an adjunct to the immunosuppressive therapy for patients with aplastic anemia.
Garnet-biotite-clinozoisite gneiss: a new type of diamondiferous metamorphic rock from the Kokchetav Massif

Clinozoisite gneisses were studied from the Barchi-Kol area, located 17 km to the west of the Kumdy-Kol microdiamond deposit at Kokchetav massif (Northern Kazakhstan). As distinct from the deposit, the studied rocks are characterized by predominance of diamonds of octahedral habit. Ultrahigh-pressure mineral assemblages were investigated mainly as inclusions in zircons from these rocks. It is established that nucleation and growth of some zircon grains began at the peak of metamorphism (T = 950–1000°C and P > 40 kbar) and continued while temperature and pressure decreased to T = 650–750°C and P = 10–12 kbar, Ultrahigh-pressure metamorphic conditions for clinozoisite gneisses from the Barchi-Kol area are comparable with those for the Kumdy-Kol microdiamond deposit and correspond to T = 900–1000°C and P > 40 kbar. High P-T of metamorphism and bulkrock composition did not affect the morphology of the diamond crystals. The abundance of fluid or melt is proposed to be responsible for the variable extent of the completeness of cuboid reshape reaction, resulting in the formation of octahedral diamond crystals. The preservation of coesite as inclusions within zircon grains, as well as within garnets, suggests the rapid cooling and fast exhumation of the studied rocks. Based on concentration profiles in garnets from diamondiferous clinozoisite rocks, the duration of retrograde metamorphism is estimated to be less than 0.1 Ma.
Produtividade de cana soca sem queima em função do uso de gesso e vinhaça

Understanding the influence of sugarcane straw over the application dynamic of vinasse and correctives is essential for an effective management of the production system. This study aimed at evaluating soil fertility, stalk yield and technological quality of ratoon sugarcane (2nd cycle), according to vinasse and gypsum application, in an Oxisol, in the Northwest Sao Paulo State, Brazil. The study was carried out with the RB867515 cultivar and the experimental design was randomized blocks with four replications, in a 2x3 factorial scheme, i.e., with and without gypsum (1.0 t ha -1 ) and vinasse application in three doses: 0.0 m 3 ha -1 (control), 100.0 m 3 ha -1 and 200.0 m 3 ha -1 . The gypsum application increased the Ca 2+ , Mg 2+ , SO 4 2- , pH and base saturation and reduced the contents of Al 3+ , in the 0-0.20 m and 0.20-0.40 m layers, and increased the SO 4 2- content in the 0.40-0.60 m layer, after 180 and 360 days, respectively. The gypsum plastering and the vinasse application did not increase the stalk yield nor improved its technologic quality.
Cool and hot executive function in conduct-disordered adolescents with and without co-morbid attention deficit hyperactivity disorder: relationships with externalizing behaviours

Background An understanding of the exact nature of executive function (EF) deficits in conduct disorder (CD) remains elusive because of issues of co-morbidity with attention deficit hyperactivity disorder (ADHD). Method Seventy-two adolescents with CD, 35 with CD + ADHD and 20 healthy controls (HCs) were assessed on a computerized battery of putative ‘cool’ and ‘hot’ EFs. Participants also completed the Child Behaviour Checklist (CBCL). Results In the cool EF tasks such as planning, the CD + ADHD group in particular showed most notable impairments compared to HCs. This pattern was less evident for set shifting and behavioural inhibition but there were significant correlations between errors scores on these tasks and indices of externalizing behaviours on the CBCL across the sample. For hot EF tasks, all clinical groups performed worse than HCs on delay of gratification and poor performance was correlated with externalizing scores. Although there were no notable group differences on the punishment-based card-playing task, there were significant correlations between ultimate payout and externalizing behaviour across groups. Conclusions Overall, our findings highlight the fact that there may be more common than distinguishing neuropsychological underpinnings to these co-morbid disorders and that a dimensional symptom-based approach may be the way forward.
Long-term use of metformin and colorectal cancer risk in type II diabetics: a population-based case–control study

In vitro and animal studies indicate that metformin prevents colorectal cancer (CRC). Epidemiological studies, however, have been equivocal. We undertook this study to assess whether metformin prevents CRC in individuals with type II diabetes. We performed a nested case–control study restricted to Danish citizens with type II diabetes. Data were collected from four Danish nationwide registries. Cases were type II diabetics with a primary CRC between 2000 and 2009, and controls were sampled among subjects with type II diabetes. Long‐term exposure to metformin was defined by the redeeming of prescriptions for a cumulative dose of 2000 g within 5 years prior to the index date. To control for potential confounders, we used unconditional logistic regression. We generated adjusted odds ratios (OR) for the association between metformin and CRC and performed subanalyses for selected subgroups and for the dose–response relation. We identified 2088 cases and 9060 controls during the study period. The association between long‐term metformin use and CRC gave an adjusted OR at 0.83 (95% CI 0.68–1.00). A protective effect on CRC with long‐term use of metformin was only evident for women (OR 0.66 vs. 0.99 for men). There was a significant dose–response association of metformin use >250 defined daily dose (DDD) and for the duration of metformin use >1 year. We found an indication of a protective effect of long‐term metformin use against CRC in type II diabetics, although this effect was only seen in women.
Newborn with Prenatally Diagnosed Choroidal Fissure Cyst and Panhypopituitarism and Review of the Literature

Abstract Little has been reported on fetal diagnosis of choroidal fissure cysts and prediction of the clinical complications that can result. We describe the case of a near-term male infant with prenatally diagnosed choroidal fissure cyst and bilateral clubfeet. His prolonged course in the neonatal intensive care nursery was marked by severe panhypopituitarism, late-onset diabetes insipidus, placement of a cystoperitoneal shunt, and episodes of sepsis. Postnatal genetic evaluation also revealed an interstitial deletion involving most of band 10q26.12 and the proximal half of band 10q26.13. The patient had multiple readmissions for medical and surgical indications and died at 6 months of age. This case represents the severe end of the spectrum of medical complications for children with choroidal fissure cysts. It highlights not only the importance of comprehensive evaluation and multidisciplinary management and counseling in such cases, but also the need for heightened vigilance in these patients.
A symmetrical Cascaded H-bridge Multilevel Inverter used as shunt active power filter for ideal and deteriorated voltage conditions

This paper discusses the use of a Cascaded H-bridge Multilevel Inverter (CHMI) as shunt active power filter (SAPF) for selective disturbing currents compensation. The main feature of the proposed approach is the use of independent DC sources, with reduced DC-link voltages, which makes such a topology an ideal candidate for medium and high power applications with increased reliability. The developed control strategy regulates independent DC-link voltages in each H-bridge cell and allows selective compensation under a variety of voltage conditions without requiring any kind of reference-frame transformation. The selective compensation strategies are based on the decompositions proposed in the Conservative Power Theory (CPT), which result in several current-related terms associated with specific load characteristics. These current components are independent from each other and are used to define different compensation strategies, which can be selective in minimizing particular effects of disturbing loads. In order to validate the possibilities and performance of the proposed control strategies, a three-phase grid with unbalanced nonlinear loading and negligible line impedance was simulated in PSIM considering ideal and deteriorated voltage conditions.