Miracle-dz/UniFAR-FTUs huggingface dataset:
Rapid detection of simulated bacteremia by centrifugation and filtration

A centrifugation-filtration procedure was developed to expedite the recovery of microorganisms from blood. Fresh whole human blood was inoculated with various aerobic and facultatively anaerobic microorganisms (3 to 18 per ml). The seeded blood was carefully overlaid on a Ficoll-Hypaque gradient (density, 1.114 g/ml) and centrifuged (400 x g) for 45 min at ambient temperature. The entire gradient (plasma, leukocytes, and Ficoll-Hypaque) was removed and filtered through a 0.22-micrometer membrane filter. The filters were then placed on chocolate agar and incubated at 35 degrees C in humidified air containing 5% CO2. No statistically significant differences were detected between the numbers of microorganisms recovered by filtration and by direct culture of the original inoculum. Most microorganisms were detected within 18 h after filtration. This system has excellent sensitivity and negligible toxicity.
Adjective production by Russian-speaking children with specific language impairment

Research on specific language impairment (SLI) has primarily focused on the acquisition of nouns and verbs. Less attention has been given to other content-word classes, such as adjectives and adverbs. This article investigates adjective production by 7- to 10-year-old Russian-speaking children with SLI and their typically developing (TD) peers and focuses on the production of antonymous adjectives and degree markers in an elicitation experiment. The results show that degree morphology is more impaired in SLI than antonymy. In antonym production, children with SLI were able to catch up with their TD peers by age 8. In the domain of degree, however, the SLI group lagged behind the TD controls across all ages studied. Error analysis indicates that language-impaired children have particular difficulty with agreement inflection and affixal negations. They also substitute adjectives with specific meanings by more general terms. The implications of this study for the morphological-richness hypothesis are discussed.
A REVIEW ON HEPATOPROTECTIVE HERBAL DRUGS

Liver is a vital organ play a major role in metabolism and excretion of xenobiotics from the body. Liver cell injury caused by various toxic chemicals (certain anti-biotic, chemotherapeutic agents, carbon tetrachloride (CCl4), thioacetamide (TAA) etc.), excessive alcohol consumption and microbes is well-studied. The available synthetic drugs to treat liver disorders in this condition also cause further damage to the liver. Hence, Herbal drugs have become increasingly popular and their use is wide-spread. Herbal medicines have been used in the treatment of liver diseases for a long time so the maintenance of a healthy liver is essential for the overall well being of an individual. Liver injury induced by toxins is more common nowadays. Herbal remedies are focused in the pharmaceutical industry to evolve a safe route for liver disorders. Therefore, hepatoprotective natural products such as Andrographic paniculata, Chamomile capitula , Silybum marianum, Coccinia grandis, Flacourtia indica, Wedelia calendulacea, Annona squamosa, Prostechea michuacana, Ficus carica, Lepidium sativum, Sargassum polycystum, Solanum nigrum, swertia chirata, Phyllanthus emblica, Curcuma longa, Picrorhiza kurroa, Azadirachta indica, Aegle marmelos, Cassia roxburghii, Orthosiphon stamineus, Jatropha curcas, Foeniculum vulgare, Trigonella foenum graecum, Eclipta alba, Garcinia mangostana Linn is reviewed. The present review is aimed at compiling data on promising Phytochemical from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.
Understanding Water Storage Practices of Urban Residents of an Endemic Dengue Area in Colombia: Perceptions, Rationale and Socio-Demographic Characteristics

Introduction The main preventive measure against dengue virus transmission is often based on actions to control Ae. Aegypti reproduction by targeting water containers of clean and stagnant water. Household water storage has received special attention in prevention strategies but the evidence about the rationale of this human practice is limited. The objective was to identify and describe water storage practices among residents of an urban area in Colombia (Girardot) and its association with reported perceptions, rationales and socio-demographic characteristics with a mixed methods approach. Methods Knowledge, attitudes and practices and entomological surveys from 1,721 households and 26 semi-structured interviews were conducted among residents of Girardot and technicians of the local vector borne disease program. A multivariate analysis was performed to identify associations between a water storage practice and socio-demographic characteristics, and knowledge, attitudes and practices about dengue and immature forms of the vector, which were then triangulated with qualitative information. Results Water storage is a cultural practice in Girardot. There are two main reasons for storage: The scarcity concern based on a long history of shortages of water in the region and the perception of high prices in water rates, contrary to what was reported by the local water company. The practice of water storage was associated with being a housewife (Inverse OR: 2.6, 95% CI 1.5 -4.3). The use of stored water depends on the type of container used, while water stored in alberca (Intra household cement basins) is mainly used for domestic cleaning chores, water in plastic containers is used for cooking. Conclusions It is essential to understand social practices that can increase or reduce the number of breeding sites of Ae. Aegypti. Identification of individuals who store water and the rationale of such storage allow a better understanding of the social dynamics that lead to water accumulation.
The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat

Nicotine and alcohol use is highly prevalent among patients with serious mental illness, including those with schizophrenia (SCZ), and this co-occurrence can lead to a worsening of medical and psychiatric morbidity. While the mechanistic drivers of co-occurring SCZ, nicotine use and alcohol use are unknown, emerging evidence suggests that the use of drugs during adolescence may increase the probability of developing psychiatric disorders. The current study used the neonatal ventral hippocampal lesion (NVHL) rat model of SCZ, which has previously been shown to have enhanced nicotine behavioral sensitization and, following adolescent alcohol, increased alcohol consumption. Given how commonly alcohol is used by adolescents that develop SCZ, we used the NVHL rat to determine how exposure to adolescent alcohol impacts the development of nicotine behavioral sensitization in adulthood. Male Sprague-Dawley rats underwent the NVHL surgery or a sham (control) surgery and subsequently, half of each group was allowed to drink alcohol during adolescence. Nicotine behavioral sensitization was assessed in adulthood with rats receiving subcutaneous injections of nicotine (0.5 mg/kg) each day for 3 weeks followed by a nicotine challenge session 2 weeks later. We demonstrate that all groups of rats became sensitized to nicotine and there were no NVHL-specific increases in nicotine behavioral sensitization. We also found that NVHL rats appeared to develop sensitization to the nicotine paired context and that adolescent alcohol exposure blocked this context sensitization. The current findings suggest that exposure to alcohol during adolescence can influence behaviors that manifest in the adult NVHL rat (i.e., context sensitization). Interestingly, nicotine behavioral sensitization levels were not altered in the NVHL groups regardless of adolescent alcohol exposure in contrast to prior reports.
Trade, foreign direct investment and economic growth in Asian economies

Despite the increasing role of foreign direct investment (FDI) in economic development, very limited research has been carried out on the causal links between trade, FDI and economic growth in Asian economies. This study examines empirically the inter-play between exports, imports, FDI and economic growth for nine Asian economies by conducting multivariate causality tests in the vector error correction model (VECM) framework. The results reveal two-way causal connections between trade, inward FDI, inward merger and acquisitions (M&As) and growth for most of the sample economies. There is a unidirectional causal link running from outward M&As to growth and trade. These findings suggest that export expansion, import liberalization, FDI inflows and inward M&As are integral elements of the growth process in Asian economies.
Capacity-Achieving PIR Schemes with Optimal Sub-Packetization

Suppose a database containing $M$ records is replicated across $N$ servers, and a user wants to privately retrieve one record by accessing the servers such that identity of the retrieved record is secret against any up to $T$ servers. A scheme designed for this purpose is called a private information retrieval (PIR) scheme. In practice, capacity-achieving and small sub-packetization are both desired for PIR schemes, because the former implies the highest download rate and the latter usually means simple realization. For general values of $N,T,M$, the only known capacity-achieving PIR scheme was designed by Sun and Jafar in 2016 with sub-packetization $N^M$. In this paper, we design a linear capacity-achieving PIR scheme with much smaller sub-packetization $dn^{M-1}$, where $d={\rm gcd}(N,T)$ and $n=N/d$. Furthermore, we prove that for any linear capacity-achieving PIR scheme it must have sub-packetization no less than $dn^{M-1}$, implying our scheme has the optimal sub-packetization. Moreover, comparing with Sun and Jafar's scheme, our scheme reduces the field size by a factor of $\frac{1}{Nd^{M-2}}$.
Clostridium butyricum Alleviates Enterotoxigenic Escherichia coli K88-Induced Oxidative Damage Through Regulating the p62-Keap1-Nrf2 Signaling Pathway and Remodeling the Cecal Microbial Community

Clostridium butyricum (CB) can enhance antioxidant capacity and alleviate oxidative damage, but the molecular mechanism by which this occurs remains unclear. This study used enterotoxigenic Escherichia coli (ETEC) K88 as a pathogenic model, and the p62-Keap1-Nrf2 signaling pathway and intestinal microbiota as the starting point to explore the mechanism through which CB alleviates oxidative damage. After pretreatment with CB for 15 d, mice were challenged with ETEC K88 for 24 h. The results suggest that CB pretreatment can dramatically reduce crypt depth (CD) and significantly increase villus height (VH) and VH/CD in the jejunum of ETEC K88-infected mice and relieve morphological lesions of the liver and jejunum. Additionally, compared with ETEC-infected group, pretreatment with 4.4×106 CFU/mL CB can significantly reduce malondialdehyde (MDA) level and dramatically increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels in the serum. This pretreatment can also greatly increase the mRNA expression levels of tight junction proteins and genes related to the p62-Keap1-Nrf2 signaling pathway in the liver and jejunum in ETEC K88-infected mice. Meanwhile, 16S rDNA amplicon sequencing revealed that Clostridium disporicum was significantly enriched after ETEC K88 challenge relative to the control group, while Lactobacillus was significantly enriched after 4.4×106 CFU/mL CB treatment. Furthermore, 4.4×106 CFU/mL CB pretreatment increased the short-chain fatty acid (SCFA) contents in the cecum of ETEC K88-infected mice. Moreover, we found that Lachnoclostridium, Roseburia, Lactobacillus, Terrisporobacter, Akkermansia, and Bacteroides are closely related to SCFA contents and oxidative indicators. Taken together, 4.4×106 CFU/mL CB pretreatment can alleviate ETEC K88-induced oxidative damage through activating the p62-Keap1-Nrf2 signaling pathway and remodeling the cecal microbiota community in mice.
Continuance Intention to Use Government 2.0 Services: The Impact of Citizens' Satisfaction and Involvement

Countries are moving toward adopting government 2.0 to enhance transparency and develop citizensâ€™ involvement and confidence. Although citizensâ€™ involvement and satisfaction are obviously important to the success of government 2.0 services, the literature lacks empirical research that confirms (or refutes) this importance. In this paper, the authors propose and validate a citizen-centric model based on information systems (IS) and consumer behaviour literature to investigate the influence of â€œinvolvementâ€ and â€œsatisfactionâ€ on the continuance intention to use government 2.0 services by using PLS structure equation modelling. A web survey with 392 users of Bahrainâ€™s e-government national portal is conducted to validate the proposed model. The findings confirm that both citizensâ€™ satisfaction and citizensâ€™ involvement have a positive effect on the continuance intention to use government 2.0 services. Also, the authors find that citizensâ€™ involvement is significantly influenced by citizensâ€™ satisfaction. Important theoretical and practical contributions are discussed in the paper.
Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils

Abstract Transient carotid artery occlusion causes ischemia/reperfusion (I/R) injury resulting in neuron and pancreatic β-cell death with consequential post-stroke hyperglycemia, which can lead to diabetes and may accelerate the development of Alzheimer's disease. Antioxidants have been shown to protect against the I/R injury and destruction of neurons. However, it is unknown whether the protection against I/R injury extends to the pancreatic β-cells. Therefore, we investigated whether treatment with ebselen, a glutathione peroxidase mimic, prevents neuronal and β-cell death following I/R in gerbils susceptible to stroke. After 28 days post artery occlusion, there was widespread neuronal cell death in the CA1 of the hippocampus and elevated IL-1β and TNF-α levels. Pretreatment with ebselen prevented the death by 56% and attenuated neurological damage (abnormal eyelid drooping, hair bristling, muscle tone, flexor reflex, posture, and walking patterns). Ischemic gerbils also exhibited impaired glucose tolerance and insulin sensitivity which induced post-stroke hyperglycemia associated with decreased β-cell mass due to increased β-cell apoptosis. Ebselen prevented the increased β-cell apoptosis, possibly by decreasing IL-1β and TNF-α in islets. Ischemia also attenuated hepatic insulin signaling, and expression of GLUT2 and glucokinase, whereas ebselen prevented the attenuation and suppressed gluconeogenesis by decreasing PEPCK expression. In conclusion, antioxidant protection by ebselen attenuated I/R injury of neurons and pancreatic β-cells and prevented subsequent impairment of glucose regulation that could lead to diabetes and Alzheimer's disease.
Bedside to Blueprints: The Role of Nurses in Hospital Design

OBJECTIVE: To explore the role and function of nurses in the healthcare design industry. BACKGROUND: The design of a new hospital requires collaboration among multiple disciplines to develop an environment that allows for high-quality care to be delivered and received. This article investigates the role of nurses as an integral part of the design team when creating optimal spaces for patients and caregivers. While nurses fulfill many roles in healthcare, this investigation focused on the role of nurses as end-users, nurse leaders, and consultants. METHODS: An informal interview method was used to elicit information from 13 members of the healthcare design industry across disciplines and across the United States. Those interviewed included nurses, architects, and consultants. RESULTS: Common themes that emerged from this investigation included the importance of nurses as an integral part of the design team and a continued need to understand optimal utilization to be an effective team member. A number of organizations and events welcome nurses to help foster design innovation and interprofessional collaboration. CONCLUSIONS: The role of the professional nurse continues to expand and there are many opportunities for nurses to step out of their traditional role and into the industry of healthcare design.
Diagnosis, staging, and monitoring of cutaneous T‐cell lymphoma

ABSTRACT: Cutaneous T‐cell lymphoma includes mycosis fungoides and its leukemic variant, the Sézary syndrome. This review discusses the clinical, histopathologic, immunophenotypic and immunogenotypic features of cutaneous T‐cell lymphoma as they apply to the diagnosis, staging and monitoring of this disease.
Modeling logMAR Visual Acuity Scores: Effects of Termination Rules and Alternative Forced-Choice Options

Background. Logarithm of the minimum angle of resolution (logMAR) charts come in a variety of alternative forced-choice (AFC) formats and can be used with a variety of different rules to determine when to stop a subject reading down a chart (termination rules). Methods. Exact calculation and Monte Carlo simulation techniques were used to compare logMAR scores for different termination rules and for infinite-, 26-, 10-, 8-, 4-, and 2-AFC logMAR chart formats. Slope-corrected standard deviation, an index of variability of the underlying ideal threshold, was used as a common metric for the different test conditions. Results. The mean and standard deviation of logMAR scores can be significantly affected by termination rules and AFC format. For different AFC formats, different termination criteria were found to give optimal slope-corrected standard deviations. Conclusion. A number of clinically suitable termination rules are proposed for different AFC format logMAR charts. For letter-by-letter scoring of Bailey-Lovie and EDTRS charts, it is recommended that researchers and practitioners use a termination rule of stopping after four or more mistakes on a line.
Bringing Kaizen to the classroom: lessons learned in an Operations Management course

The managerial approach of Kaizen is used by different organisations around the world in order to improve the performance of their work processes and operations. Both the Total Quality Management literature and Kaizen have shown different efforts to illustrate the application of this approach in the traditional classroom-style business education. Also, business schools have a clear need for showing consistency between what is being taught in the classroom and what is being done in the day-to-day operations of the organisation. The purpose of this article is to describe the systematic application of Kaizen and its learned lessons during the last three years in the Operations Management (OM) course from the Master in Business Administration graduate programme taught at the Mexican Business School. An exploratory qualitative study was conducted. This research project provides empirical evidence of how Kaizen's continuous improvement cycle (PDCA) enables better results in students who have taken the subject of OM in a business school. The findings in each phase of the cycle show the Kaizen-oriented improvement actions and the results obtained in final grades (exam) and written reports. Finally, the study contributes to the limited existing literature on Kaizen in education and subsequently disseminates this information in order to provide impetus, guidance and support towards improvement in the quality of teaching in a business school.
Ethnic Power Sharing: Three Big Problems

In societies severely divided by ethnicity, race, religion, language, or any other form of ascriptive affiliation, ethnic divisions make democracy difficult, because they tend to produce ethnic parties and ethnic voting. Two commonly proposed methods of amelioration are called consociational and centripetal. Three problems derive from these proposals: The first concerns the adoptability of either of the two principal prescriptions. Under what conditions can either be adopted? The second relates to a possibility inherent in centripetal regimes: the potential degradation of the electoral arrangements that sustain the interethnic coalition. The third derives from a common consequence of the adoption of a consociational regime: Where robust guarantees, including minority vetoes, are adopted, immobilism is a strong possibility, and it may be very difficult to overcome the stasis that immobilism can produce. By examining these three problems, we can uncover some of the frailties inherent in both of the common prescriptions.
TOURISM SENSE‐MAKING: THE ROLE OF THE SENSES AND TRAVEL JOURNALISM

The tourist experience is corporeal and multisensory. Tourism organizations, therefore, need to pay attention to the sensual content of promotional messages conveyed to potential tourists to provide incentives for seeking enriched experiences of place. Together with other image formation agents, travelogues (travel articles published in newspapers and magazines) offer information on and prompt imagination about destinations that help frame visitors' expectations and influence their subsequent travel decisions and behaviors. This article content‐analyzed 199 travelogues about New Zealand to identify relationships between regions and perceptions based on sensory allusions. It was found that the reporting of New Zealand as a whole by visiting journalists tended to utilize an appeal to all senses, but this was not true of individual destinations. It is suggested that urban destinations such as Auckland and Wellington possess potential for a wider sense appeal than is currently used through products based on urban adventure tourism and culinary tourism. An “ideal” itinerary is proposed that would permit journalists to capture a sensory experience of New Zealand.
Drought Concepts and Characterization

Abstract A better knowledge of droughts is required to improve water management in water scarce areas. To appropriately cope with droughts, there is the need to adopt adequate concepts relative to droughts and water scarcity, to properly use drought indices that help characterize them, including ones relative to their severity, and to develop prediction tools that may be useful for early warning and that may reduce the respective lead time needed for appropriate response. In this paper, concepts relative to drought and other water scarcity regimes are discussed aiming both to distinguish droughts from other water scarcity regimes and to base a common understanding of the general characteristics of droughts as hazards and disasters. Three main drought indices are described aiming at appropriate characterization of droughts: the theory of runs, the Palmer Drought Severity Index (PDSI), and the Standardized Precipitation Index (SPI). Their application to local and regional droughts in the region of Alentejo, Portugal is presented focusing on the respective comparison and possible adequateness for drought monitoring. Results indicate some difficulties in using the theory of runs, particularly because it requires a subjective definition of thresholds in precipitation and does not provide a standardized classification of severity. Results show that draught characterization with the PDSI and the SPI produce coherent information, but the PDSI is limited relative to the SPI because it requires more data to perform a soil water balance while the SPI needs only precipitation data, which are more easily available in numerous locations. It is concluded that adopting the SPI is appropriate, but there is advantage in combining different indices to characterize droughts.