Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancement of memory in rats with Centella asiatica

Numerous medicinal plants are mentioned in ancient Indian literature as cognition enhan-cers. Among these plants, Centella asiatica (CeA) has been used to improve memory. This study demonstrated the effect of CeA on learning ability and memory in male Wistar rats. The rats were trained at various periods by intragastric administration of CeA to the test group at a dosage of 2mg / 0.5 ml of distilled water/day (12mg/ kg body weight) for 10 days and compared with the control group by an Operant conditioning technique, n = 6 in both groups. The two important parameters studied were latency period and the total number of bar pressings which correspond to memory retention and task learning respectively. The re-sults were analyzed using the paired Student’s t-test. The CeA treated group showed a sig-nificant decrease in the latency period as compared to controls which suggested an im-provement in retaining the learnt task as good retention of memory (P < 0.05). The number of bar pressings did not change significantly in the test group, due to lack of CeA action on the learning process. The results conclude that the CeA had facilitated the retention of a learnt task for a longer period as good retension of memory but did not accelerated the learning process as expected.
On detection and annihilation of spherical virus embedded in a fluid matrix at low and moderate Reynolds number

Effect of high and low Reynolds number is studied on low frequency vibrational modes of a spherical virus embedded in the aqueous medium. We have used an analytical approach based on fluid dynamic and classical Lamb theory to calculate the vibrational modes of a virus with material parameters of lysozyme crystal in water. The obvious size effect on the vibrational modes is observed. The estimated damping time which is of the order of picosecond varies with Reynolds number and shows a high value for a critical Reynolds number. The stationary eigenfrequency regions are observed for every quantum number l and n suggesting the most probable Re ranges for acoustic treatment of viruses in order to detect or annihilate the virus using corresponding viruswater configuration.
Canopy-scale biophysical controls of transpiration and evaporation in the Amazon Basin

Abstract. Canopy and aerodynamic conductances (gC and gA) are two of the key land surface biophysical variables that control the land surface response of land surface schemes in climate models. Their representation is crucial for predicting transpiration (λET) and evaporation (λEE) flux components of the terrestrial latent heat flux (λE), which has important implications for global climate change and water resource management. By physical integration of radiometric surface temperature (TR) into an integrated framework of the Penman–Monteith and Shuttleworth–Wallace models, we present a novel approach to directly quantify the canopy-scale biophysical controls on λET and λEE over multiple plant functional types (PFTs) in the Amazon Basin. Combining data from six LBA (Large-scale Biosphere-Atmosphere Experiment in Amazonia) eddy covariance tower sites and a TR-driven physically based modeling approach, we identified the canopy-scale feedback-response mechanism between gC, λET, and atmospheric vapor pressure deficit (DA), without using any leaf-scale empirical parameterizations for the modeling. The TR-based model shows minor biophysical control on λET during the wet (rainy) seasons where λET becomes predominantly radiation driven and net radiation (RN) determines 75 to 80 % of the variances of λET. However, biophysical control on λET is dramatically increased during the dry seasons, and particularly the 2005 drought year, explaining 50 to 65 % of the variances of λET, and indicates λET to be substantially soil moisture driven during the rainfall deficit phase. Despite substantial differences in gA between forests and pastures, very similar canopy–atmosphere "coupling" was found in these two biomes due to soil moisture-induced decrease in gC in the pasture. This revealed the pragmatic aspect of the TR-driven model behavior that exhibits a high sensitivity of gC to per unit change in wetness as opposed to gA that is marginally sensitive to surface wetness variability. Our results reveal the occurrence of a significant hysteresis between λET and gC during the dry season for the pasture sites, which is attributed to relatively low soil water availability as compared to the rainforests, likely due to differences in rooting depth between the two systems. Evaporation was significantly influenced by gA for all the PFTs and across all wetness conditions. Our analytical framework logically captures the responses of gC and gA to changes in atmospheric radiation, DA, and surface radiometric temperature, and thus appears to be promising for the improvement of existing land–surface–atmosphere exchange parameterizations across a range of spatial scales.
Single-nucleotide polymorphisms related to fluoroquinolone and aminoglycoside resistance in Mycobacterium avium isolates

Objective The relationships between fluoroquinolone and aminoglycoside resistance and single-nucleotide polymorphisms (SNPs) in gyrA, gyrB, and rpsL genes were investigated in 95 clinical isolates of Mycobacterium avium from China. Methods Fluoroquinolone and aminoglycoside resistance were determined by the broth microdilution method. GyrA, gyrB, and rpsL were sequenced, SNPs were identified, and the corresponding amino acid mutations were recorded. Results The M. avium isolates displayed high levels of ofloxacin (93.68%), ciprofloxacin (92.63%), and streptomycin (65.26%) resistance. Moxifloxacin (18.95%) and amikacin (2.11%) were highly active against the strains. Fluoroquinolone resistance involving gyrA and gyrB gene mutations was identified. For gyrA, the most frequent SNPs were T→C (71/95, 74.74%), followed by A→G (64/95, 67.37%) and T→C (62/95, 65.26%). The amino acid mutations occurred mainly at Gly2444Asp (GGT→GAT) (20/95, 21.05%), Ala2445Ser (GCC→TCC) (20/95, 21.05%), Ala2447Val (GCC→GTC) (20/95, 21.05%), Val2449Ile (GTC→ATC) (20/95, 21.05%), and Glu2450Gln (GAA→CAA) (20/95, 21.05%). Prominent SNPs in gyrB included A→C (69/95, 72.63%), C→T (51/95, 53.68%), and T→G (29/95, 30.53%), and their amino acid substitutions were Ile2160Val (ATT→GTT) (21/95, 22.11%), Ile2160Met (ATT→ATG) (20/95, 21.05%), and Ile2273Leu (ATC→CTC) (11/95, 11.58%). Among the strains with aminoglycoside resistance, SNPs in rpsL were identified mostly at position G→A (73/95, 76.84%). G→C (21/95, 22.11%) was commonly seen. The amino acid mutations primarily involved Ala1539985Thr (GCC→ACC) (19/95, 20.00%), His1539992Asp (CAC→GAC) (19/95, 20.00%), and Gln-1539983Glu (CAG→GAG) (18/95, 18.95%). Conclusion Our study provides valuable information that could be used for the future diagnosis and treatment of M. avium disease.
CRT based multi-secret sharing schemes: revisited

Secret sharing is a cryptographic primitive, which is used to distribute a secret among a set of participants in such a way that an authorised subset of participants can uniquely reconstruct the secret and an unauthorised subset can get no information about the secret. In this paper, we propose multi-stage multi-secret sharing scheme based on Mignotte's sequence and multi-level multi-secret sharing scheme based on Asmuth's Bloom sequence. The advantage of the proposed schemes is that the secret space is larger than that of the existing schemes. There is no leakage of information through public values. Novelty of these schemes is that the participants can reuse their shares for each new set of secrets without refreshing their shares. Moreover, the first scheme can verify the honesty of both the dealer and participants. The correctness of the proposed schemes is discussed and shows that the proposed schemes are computationally secure.
Responses of seagrass communities to fertilization along a gradient of relative availability of nitrogen and phosphorus in a carbonate environment

Patterns of relative nutrient availability in south Florida suggest spatial differences regarding the importance of nitrogen (N) and phosphorus (P) to benthic primary producers. We did a 14‐month in situ fertilization experiment to test predictions of N and P limitation in the subtropical nearshore marine waters of the upper Florida Keys. Six sites were divided into two groups (nearshore, offshore) representing the endpoints of an N: P stoichiometric gradient. Twenty‐four plots were established at each site with six replicates of each treatment (+N, +P, +N+P, control), for a total of 144 experimental plots. The responses of benthic communities to N and P enrichment varied appreciably between nearshore and offshore habitats. Offshore seagrass beds were strongly limited by nitrogen, and nearshore beds were affected by nitrogen and phosphorus. Nutrient addition at offshore sites increased the length and aboveground standing crop of the two seagrasses, Thalassia testudinum and Syringodium filiforme, and growth rates of T. testudinum. Nutrient addition at nearshore sites increased the relative abundance of macroalgae, epiphytes, and sediment microalgae. N limitation of seagrass in this carbonate system was clearly demonstrated. However, added phosphorus was retained in the system more effectively than N, suggesting that phosphorus might have important long‐term effects on these benthic communities. The observed species‐specific responses to nutrient enrichment underscores the need to monitor all primary producers when addressing questions of nutrient limitation and eutrophication in seagrass communities.
Comparative study between natural and synthetic Hydroxyapatite: structural, morphological and bioactivity properties

In this work, a study of hydroxyapatite (HAp) powders obtained using both, porcine bones and chemical precursors was carried put. In the case of HAp obtained by means of porcine bones, physical processes as cooking, washing and milling were developed, for removing the organic material from the bones; after that, the powders were submitted to a thermal treatment at 800 °C, during 12 h. This procedure was carried out without adding chemical alkalines that are harmful for the environment and the human health. On the other hand, HAp powders were also synthetized using the chemical precipitation method widely reported, showing successful results. Moreover, both kind of powders were characterized using x ray diffraction, Fourier transformer infrared spectroscopy, scanning electron microscopy and energy dispersive spectroscopy. Furthermore, the bioactivity of the materials was determined using the simulated biological fluid (SBF) method. Results showed that the natural HAp exhibited better crystallographic properties. Moreover, according to these results, HAp obtained from porcine bones contains traces of elements as Na and Mg that are favorable for the bioactivity, according to the materials behavior when they are immersed in SBF. Keywords: Hydroxyapatite, porcine bones, chemical precipitation, simulated biological fluid.
Ecological opportunity and levels of morphological variance within freshwater stickleback populations

The ‘ecological opportunity’ hypothesis predicts that when interspecific competition or predation is reduced, populations will exhibit increases in phenotypic variance as a result of colonization and adaptation to vacant or underutilized ecological niches (i.e. character release). We assessed this hypothesis by examining morphological diversity within stickleback populations in 40 undisturbed lakes from six islands off the mid-coast of British Columbia, Canada. Because larger lakes with well-developed littoral and limnetic zones will have greater trophic niche diversity than smaller lakes with only littoral zones, we predicted a positive association between lake size and variation in trophic morphology. Conversely, reduced vertebrate predation in small bog lakes allows increased variance in defensive structures without costs to fitness. Consistent with both predictions, we observed that phenotypic variance in two traits that are involved in feeding (gape width and pectoral fin length) increased with lake size while variability in defence structures (lateral plate number and dorsal spine length) was inversely related to lake size. Moreover, increased variance in defence morphology was accentuated in populations with severe armour reduction (spine loss, decreased plate overlap), another strong indicator of reduced vertebrate predation. In the majority of cases, these patterns were repeatable among islands, independent from the geographical distance between lakes, and arose from a combination of high variance within each of the sexes and increases in sexual dimorphism. These findings suggest that character release can be trait-specific and reflect the combined effects of competition, predation and habitat heterogeneity. © 2005 The Linnean Society of London, Biological Journal of the Linnean Society, 2005, 86, 297–308.
Abused boys, battered mothers, and male involvement in teen pregnancy.

BACKGROUND The relationship between boyhood exposure to physical abuse, sexual abuse, or to a battered mother and subsequent risk of impregnating a teenage girl has not previously been examined. METHODS In a retrospective cohort study set in a primary care clinic for adult members of a large health maintenance organization, questionnaire responses from 4127 men were analyzed. Respondents provided the age of the youngest female whom they had impregnated, their own ages at the time, and information regarding childhood exposure to physical or sexual abuse and battered mothers. We calculated the prevalence and adjusted odds ratio (OR) for having impregnated a teenage girl according to these 3 adverse childhood experiences, regardless of the male's age at the time of impregnation. Using logistic regression, ORs were adjusted for the male's age at time of survey, race, and education. RESULTS Nineteen percent of the men reported that they had ever impregnated a teenage girl. During childhood, 32% of respondents had been physically abused, 15% sexually abused, and 11% had battered mothers. Compared with respondents reporting no abuse, frequent physical abuse or battering of mothers increased the risk of involvement in teen pregnancy by 70% (OR: 1.7; 95% confidence interval [CI]: 1.2-2.5) and 140% (OR: 2.4; 95% CI: 1.1-5.0), respectively. Sexual abuse as a boy at age 10 years or younger increased the risk of impregnating a teenage girl by 80% (OR: 1.8; 95% CI: 1.3-2.4); sexual abuse with violence increased the risk by 110% (OR: 2.1; 95% CI: 1.2-3.4). We found a dose-response relationship between the number of types of exposures and the risk of impregnating a teenage girl; men who reported all 3 types of exposures were more than twice as likely to have been involved than those with no exposures (OR: 2.2; 95% CI: 1.4-3.5). CONCLUSIONS Boyhood exposure to physical or sexual abuse or to a battered mother is associated with an increased risk of involvement in a teen pregnancy-during both adolescence and adulthood. Because these exposures are common and interrelated, boys and adult men who have had these experiences should be identified via routine screening by pediatricians and other health care providers and counseled about sexual practices and contraception. Such efforts may prevent teen pregnancy and the intergenerational transmission of child abuse and domestic violence.
Effects of Alkaloid Rich Extract of Citrullus colocynthis Fruits on Artemia Salina and Human Cancerous (MCF-7 AND HEPG-2) Cells

In the present research the anti-cancer effect of alkaloid rich extract of Citrullus colocynthis fruits was investigated. The cytotoxic effect were evaluated in two phase, initially the effect of the extract were demonstrated on brine shrimp lethality assay (on freshly hatched napolii of Artemia salina). The effect of the extract exhibited strong cytotoxic effect (LC50=3.30µg/mL) due to its potent cytotoxicity components. On the second stage its anti cancer activity has been analysed on human cancerous cells. Initially the effect has been evaluated on MCF-7 cells which exhibited significant reduction in cell viability in dose dependant manner (LC50=17.2µg/mL) in very low concentration at 5µg/mL, 10µg/mL, 20µg/mL. Similar effect has been observed in human hepatoma cells (HepG-2), proved to be potent anti-cancer moiety (LC50=12.54µg/mL). These effects were observed maintained even after 48 and 72 hours (time dependant manner).
On out-of-band emissions of quantized precoding in massive MU-MIMO-OFDM

We analyze out-of-band (OOB) emissions in the massive multi-user (MU) multiple-input multiple-output (MIMO) downlink. We focus on systems in which the base station (BS) is equipped with low-resolution digital-to-analog converters (DACs) and orthogonal frequency-division multiplexing (OFDM) is used to communicate to the user equipments (UEs) over frequency-selective channels. We demonstrate that analog filtering in combination with simple frequency-domain digital predistortion (DPD) at the BS enables a significant reduction of OOB emissions, but degrades the signal-to-interference-noise-and-distortion ratio (SINDR) at the UEs and increases the peak-to-average power ratio (PAR) at the BS. We use Bussgang's theorem to characterize the tradeoffs between OOB emissions, SINDR, and PAR, and to study the impact of analog filters and DPD on the error-rate performance of the massive MU-MIMO-OFDM downlink. Our results show that by carefully tuning the parameters of the analog filters, one can achieve a significant reduction in OOB emissions with only a moderate degradation of error-rate performance and PAR.
Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study

Purpose To evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing signs and symptoms of dry eye disease (DED) in a large patient population. Methods A retrospective chart review at 10 clinical sites was done of patients with refractory DED who received CAM and completed at least 3 months of follow-up. Data collected were demographics; medical history including previous and current ocular treatment, diagnosis, clinical presentations, comorbidity, duration and frequency of treatment with CAM; and concomitant medications. The primary outcome was the change in dry eye workshop (DEWS) score after treatment. Results A total of 97 eyes of 84 patients exhibited severe dry eye despite maximal medical treatments including topical artificial tears, cyclosporine-A, serum, antibiotics, and steroids. Patients manifested with superficial punctate keratitis (86%), filamentary keratitis (13%), exposure keratitis (19%), neurotrophic keratitis (2%), and corneal epithelial defect (7%). After CAM treatment for 5.4±2.8 days, 74 (88%) patients demonstrated an improved ocular surface along with a notable reduction of the severity as the overall DEWS score was significantly reduced from 3.25±0.5 at baseline to 1.44±0.6 at 1 week, 1.45±0.6 at 1 month, and 1.47±0.6 at 3 months (p<0.001). Ten eyes (10%) required repeated treatment to complete healing. Apart from discomfort during CAM placement, there were no adverse events. Conclusion Placement of CAM is promising to enhance the recovery of ocular surface health and reduce signs and symptoms in patients with moderate-to-severe DED.
Plant diversity enhances productivity and soil carbon storage

Significance Soil carbon sequestration plays an important role in mitigating anthropogenic increases in atmospheric CO2 concentrations. Recent studies have shown that biodiversity increases soil organic carbon (SOC) storage in experimental grasslands. However, the effects of species diversity on SOC storage in natural ecosystems have rarely been studied, and the potential mechanisms are yet to be understood. The results presented here show that favorable climate conditions, particularly high precipitation, tend to increase both species richness and belowground biomass, which had a consistent positive effect on SOC storage in forests, shrublands, and grasslands. Nitrogen deposition and soil pH generally have a direct negative effect on SOC storage. Ecosystem management that maintains high levels of plant diversity can enhance SOC storage and other ecosystem services that depend on plant diversity. Despite evidence from experimental grasslands that plant diversity increases biomass production and soil organic carbon (SOC) storage, it remains unclear whether this is true in natural ecosystems, especially under climatic variations and human disturbances. Based on field observations from 6,098 forest, shrubland, and grassland sites across China and predictions from an integrative model combining multiple theories, we systematically examined the direct effects of climate, soils, and human impacts on SOC storage versus the indirect effects mediated by species richness (SR), aboveground net primary productivity (ANPP), and belowground biomass (BB). We found that favorable climates (high temperature and precipitation) had a consistent negative effect on SOC storage in forests and shrublands, but not in grasslands. Climate favorability, particularly high precipitation, was associated with both higher SR and higher BB, which had consistent positive effects on SOC storage, thus offsetting the direct negative effect of favorable climate on SOC. The indirect effects of climate on SOC storage depended on the relationships of SR with ANPP and BB, which were consistently positive in all biome types. In addition, human disturbance and soil pH had both direct and indirect effects on SOC storage, with the indirect effects mediated by changes in SR, ANPP, and BB. High soil pH had a consistently negative effect on SOC storage. Our findings have important implications for improving global carbon cycling models and ecosystem management: Maintaining high levels of diversity can enhance soil carbon sequestration and help sustain the benefits of plant diversity and productivity.
Spared Ability to Perceive Direction of Locomotor Heading and Scene-Relative Object Movement Despite Inability to Perceive Relative Motion

Background All contemporary models of perception of locomotor heading from optic flow (the characteristic patterns of retinal motion that result from self-movement) begin with relative motion. Therefore it would be expected that an impairment on perception of relative motion should impact on the ability to judge heading and other 3D motion tasks. Material/Methods We report two patients with occipital lobe lesions whom we tested on a battery of motion tasks. Patients were impaired on all tests that involved relative motion in plane (motion discontinuity, form from differences in motion direction or speed). Despite this they retained the ability to judge their direction of heading relative to a target. A potential confound is that observers can derive information about heading from scale changes bypassing the need to use optic flow. Therefore we ran further experiments in which we isolated optic flow and scale change. Results Patients’ performance was in normal ranges on both tests. The finding that ability to perceive heading can be retained despite an impairment on ability to judge relative motion questions the assumption that heading perception proceeds from initial processing of relative motion. Furthermore, on a collision detection task, SS and SR’s performance was significantly better for simulated forward movement of the observer in the 3D scene, than for the static observer. This suggests that in spite of severe deficits on relative motion in the frontoparlel (xy) plane, information from self-motion helped identification objects moving along an intercept 3D relative motion trajectory. Conclusions This result suggests a potential use of a flow parsing strategy to detect in a 3D world the trajectory of moving objects when the observer is moving forward. These results have implications for developing rehabilitation strategies for deficits in visually guided navigation.