Miracle-dz/UniFAR-FTUs huggingface dataset:
Chronic bronchitis in West Sweden – a matter of smoking and social class

Background Although chronic bronchitis is associated with impaired quality of life, hospitalisations and increased mortality, it has been less in focus after the introduction of the term chronic obstructive pulmonary disease (COPD). There are no recent published data on the prevalence of chronic bronchitis from the Scandinavian countries. Aim The main aim of the present study was to estimate the prevalence of chronic bronchitis in West Sweden by using data from a large-scale epidemiological study of the general population. A further aim was to identify current risk factors for chronic bronchitis in a population with a major decrease in the proportion of smokers. Methods From the 18,087 questionnaire responders out of 30,000 invited to participate at the West Sweden Asthma Study, 2,000 subjects were randomly selected and invited to detailed clinical examinations performed during 2009–2013. A total of 1,172 subjects aged 17–79 participated in the examinations which included, among others, spirometry and structured interviews. Chronic bronchitis was defined according to reported symptoms. Results The overall prevalence of chronic bronchitis was 7.2% (men 7.6%; women 6.8% ns), and it was 8.7% in subjects older than age 60. Chronic bronchitis was strongly associated with smoking, defined both as current smoking status and pack-years. Other risk factors were increasing age, low socio-economic class and urban living. Of those with chronic bronchitis, 22% fulfilled the GOLD criteria of COPD. Conclusion The prevalence of chronic bronchitis was somewhat lower than found by studies in Sweden in the 1980s and the prevalence was now similar in men and women. Although smoking was still the dominating risk factor for chronic bronchitis, the relative importance of smoking had decreased parallel with a decreasing smoking prevalence, while the relative importance of other factors than smoking had increased compared to previous studies.
Additive Effects of Intra-articular Injection of Growth Hormone and Hyaluronic Acid in Rabbit Model of Collagenase-induced Osteoarthritis

In a rabbit model of collagenase-induced osteoarthritis, the additive effects of intra-articular recombinant human growth hormone (GH) administration to hyaluronic acid (HA) were evaluated. After intra-articular collagenase injection, mature New Zealand white rabbits (n=30) were divided into 3 groups. Group 1 (control rabbits) received once weekly intra-articular saline injections for 4 weeks. Group 2 rabbits received 6 mg HA injections, and group 3 rabbits were injected with 6 mg HA and 3 mg recombinant human GH. These injections were initiated 4 weeks after collagenase injections. Lameness was observed for 9 weeks after collagenase injections. Macroscopic and histopathological knee joint findings were also evaluated at the end of 9 weeks after collagenase injections. Although all animals had lameness after collagenase injections, the duration and severity of lameness were significantly shorter and less severe in group 3 than group 1 and 2 (P<0.01). Macroscopic scores showed that femoral condyles of group 3 rabbits received significantly less cartilage damage than those of groups 1 and 2 rabbits (P<0.01). Histopathological score was also the lowest in group 3 (P<0.01). These results suggest that co-injection of intra-articular HA and recombinant human GH is more effective than HA injections alone in an osteoarthritis model.
Effects of distinct populations of adenosine receptors in the ventral striatum on cocaine seeking

Drug-associated cues or pharmacological stimuli induce cocaine seeking by enhancing dopamine and glutamate neurotransmission in the nucleus accumbens (NAc). Adenosine is an inhibitory neuromodulator of dopamine and glutamate signaling and represents a viable target for decreasing relapse vulnerability. Postsynaptic adenosine A1 receptors and adenosine A2A receptors co-localize with dopamine receptors on distinct populations of medium spiny neurons in the NAc. The co-localization of dopamine and adenosine receptors is meaningful in that adenosine receptor stimulation antagonizes dopamine receptor signaling and alters the activity of NAc output pathways. Presynaptic adenosine receptors are expressed on glutamate terminals in the NAc where A1 receptors inhibit and A2A receptors enhance glutamate release in the NAc. The overarching goal of these studies was to determine the how distinct populations of adenosine receptors modulate striatal signaling to influence cocaine seeking. Our results indicate that adenosine receptors oppositely modulate cocaine seeking depending on the receptor subtype and their synaptic locale. Postsynaptic adenosine A2A receptor stimulation in the NAc decreases cocaine seeking by disrupting dopamine D2 receptor signaling in the NAc. Postsynaptic blockade of adenosine A2A receptors enhances cocaine seeking by facilitating dopamine D2 receptor signaling. Blockade of
Multimodal music emotion classification using AdaBoost with decision stumps

We propose using AdaBoost with decision stumps to implement multimodal music emotion classification (MEC) as a more appropriate alternative to the conventional SVMs. By modeling the presence or absence of salient phrases in the lyric texts and seeking for proper thresholds for certain audio signal features, it exploits interdependencies between aspects from both modalities in the multimodal MEC system to make the final classification. It can especially prevent the “short text problem” in lyrics. Our accuracy reached an average of 78.19% for classifying 3766 unique songs into 14 emotion categories, with a statistically significant improvement over the audio-only and lyrics-only monomodal MEC systems. We also show that the proposed AdaBoost with decision stumps method performs statistically better on multimodal MEC than the well-known SVM classifier, which only has an average accuracy of 72.08%.
Accurate developer recommendation for bug resolution

Bug resolution refers to the activity that developers perform to diagnose, fix, test, and document bugs during software development and maintenance. It is a collaborative activity among developers who contribute their knowledge, ideas, and expertise to resolve bugs. Given a bug report, we would like to recommend the set of bug resolvers that could potentially contribute their knowledge to fix it. We refer to this problem as developer recommendation for bug resolution. In this paper, we propose a new and accurate method named DevRec for the developer recommendation problem. DevRec is a composite method which performs two kinds of analysis: bug reports based analysis (BR-Based analysis), and developer based analysis (D-Based analysis). In the BR-Based analysis, we characterize a new bug report based on past bug reports that are similar to it. Appropriate developers of the new bug report are found by investigating the developers of similar bug reports appearing in the past. In the D-Based analysis, we compute the affinity of each developer to a bug report based on the characteristics of bug reports that have been fixed by the developer before. This affinity is then used to find a set of developers that are “close” to a new bug report. We evaluate our solution on 5 large bug report datasets including GCC, OpenOffice, Mozilla, Netbeans, and Eclipse containing a total of 107,875 bug reports. We show that DevRec could achieve recall@5 and recall@10 scores of 0.4826-0.7989, and 0.6063-0.8924, respectively. We also compare DevRec with other state-of-art methods, such as Bugzie and DREX. The results show that DevRec on average improves recall@5 and recall@10 scores of Bugzie by 57.55% and 39.39% respectively. DevRec also outperforms DREX by improving the average recall@5 and recall@10 scores by 165.38% and 89.36%, respectively.
Social and Political Citizenship in European Public Opinion: An Empirical Analysis of T.H. Marshall’s Concept of Social Rights

Normative democratic theory assumes that political systems should ensure civil, political and social rights, and this claim has become more salient since the economic crisis that began in 2008. This conception of citizenship was developed most prominently by T.H. Marshall (1950), and it has been further elaborated by numerous other authors, resulting in a clear division between procedural/electoral democracy concepts and authors emphasizing egalitarian concepts of democracy. We use latent class analysis to assess democratic ideals among European citizens as reported in the 2012 European Social Survey. The findings demonstrate that a majority of Europeans consider political and social rights as equally important, while some citizens predominantly emphasize either political or social rights. Furthermore, the focus on social rights is not limited to those with left-leaning ideologies. Considering current manifestations of discontent about the politics of austerity, we discuss the implications of social citizenship concepts for democratic legitimacy in Europe.
Genetics of early cancer detection behaviours in Australian female twins

Abstract Early detection of cervical and breast cancers is an important component of women's health strategy. Screening programmes, health professional interventions and preventive behaviours such as breast self-examination provide the means to this end. Our twin study sought to identify the relative influence of environmental and genetic factors on liability to early cancer detection behaviours, including use of cervical smear tests, mammograms, and breast examination. Additive genetic and random environmental effects models gave the best, most parsimonious fit to the data for each early cancer detection behaviour. The heritability of liability to Pap smear use was 66%, mammogram use 50%, breast examination by a doctor or nurse 38% and breast self-examination 37%. Genetic influences were behaviour-specific; there was no evidence for a common genetic influence on the four behaviours. Potential covariates investigated included age, amount of contact between co-twins, educational level and personality traits such as harm avoidance, novelty seeking, reward dependence, neuroticism, anxiety, depression, self-esteem, perceived control, interpersonal dependency and ways of coping. None were significant. The study was carried out before the implementation of national screening programmes with media campaigns to increase participation rates. Hence follow-up investigation, including data on regularity of behaviours, would be informative
Discovery and Characterization of a Potent and Selective Inhibitor of Aedes aegypti Inward Rectifier Potassium Channels

Vector-borne diseases such as dengue fever and malaria, which are transmitted by infected female mosquitoes, affect nearly half of the world's population. The emergence of insecticide-resistant mosquito populations is reducing the effectiveness of conventional insecticides and threatening current vector control strategies, which has created an urgent need to identify new molecular targets against which novel classes of insecticides can be developed. We previously demonstrated that small molecule inhibitors of mammalian Kir channels represent promising chemicals for new mosquitocide development. In this study, high-throughput screening of approximately 30,000 chemically diverse small-molecules was employed to discover potent and selective inhibitors of Aedes aegypti Kir1 (AeKir1) channels heterologously expressed in HEK293 cells. Of 283 confirmed screening ‘hits’, the small-molecule inhibitor VU625 was selected for lead optimization and in vivo studies based on its potency and selectivity toward AeKir1, and tractability for medicinal chemistry. In patch clamp electrophysiology experiments of HEK293 cells, VU625 inhibits AeKir1 with an IC50 value of 96.8 nM, making VU625 the most potent inhibitor of AeKir1 described to date. Furthermore, electrophysiology experiments in Xenopus oocytes revealed that VU625 is a weak inhibitor of AeKir2B. Surprisingly, injection of VU625 failed to elicit significant effects on mosquito behavior, urine excretion, or survival. However, when co-injected with probenecid, VU625 inhibited the excretory capacity of mosquitoes and was toxic, suggesting that the compound is a substrate of organic anion and/or ATP-binding cassette (ABC) transporters. The dose-toxicity relationship of VU625 (when co-injected with probenecid) is biphasic, which is consistent with the molecule inhibiting both AeKir1 and AeKir2B with different potencies. This study demonstrates proof-of-concept that potent and highly selective inhibitors of mosquito Kir channels can be developed using conventional drug discovery approaches. Furthermore, it reinforces the notion that the physical and chemical properties that determine a compound's bioavailability in vivo will be critical in determining the efficacy of Kir channel inhibitors as insecticides.
Aspiration paradoxes: working-class student conceptions of power in ‘engines of social mobility’

Abstract This paper examines the relationship between ‘aspiration’ and identity as rendered within discourses of power. Focusing on the deeply ingrained values of a group of 23 white working-class boys from South London (aged 14–16), the research critically considers the conception of power within a neoliberal era which produces both new subjectivities and new counter-narratives. The research examines a group of boys who fully acknowledge that post-compulsory education would enhance their power in society but who simultaneously articulated how accruing power made them feel uncomfortable. There exists a tension between the working-class values inculcated in the community and the neoliberal prerogatives of the school; as a result, their shared habitus engages in a continual process of reconciling competing and contrasting conceptions of what it is to be powerful.
Practical Management of Complex Regional Pain Syndrome

Complex regional pain syndrome (CRPS) describes a diversity of painful conditions following trauma, coupled with abnormal regulation of blood flow and sweating, trophic changes, and edema of skin. The excruciating pain and diverse autonomic dysfunctions in CRPS are disproportionate to any inciting and recovering event. CRPS type I is formerly identified as “reflex sympathetic dystrophy. ” CRPS type II is the new term for “causalgia” that always coexists with documented nerve injury. The present diagnostic criteria of CRPS I and II depend solely on meticulous history and physical examination without any confirmation by specific test procedure (or gold standard). There are only few clinical studies with large-scale randomized trials of pharmacologic agents on the treatment of CRPS. Bisphosphonates have been studied in multiple controlled trials, based on theoretical benefit of bone resorption, to offer pain relief and functional improvement in patients with CRPS. Many current rationales in treatment of CRPS (such as topical agents, antiepileptic drugs, tricyclic antidepressants, and opioids) are mainly dependent on efficacy originate in other common conditions of neuropathic pain. There are additional innovative therapies on CRPS that are still in infancy. No wonder all the treatment of individual CRPS case nowadays is pragmatic at best. Although the interventional therapies in CRPS (such as nerve blockade, sympathetic block, spinal cord and peripheral nerve stimulation, implantable spinal medication pumps, and chemical and surgical sympathectomy) may offer more rapid response, yet it is still controversial with unpredictable outcome. Nevertheless, we need to start pain management immediately with the ambition to restore function in every probable case of CRPS. An interdisciplinary setting with comprehensive approach (pharmacologic, interventional, and psychological in conjunction with rehabilitation pathway) has been proposed as protocol in the practical management of CRPS. It is crucial to have a high sensitivity value combined with a fair specificity in revising diagnostic criteria of CRPS. The validation and consensus for new rationalized diagnostic criteria of CRPS could facilitate further research to enhance clinical outcome including quality of life. These endeavors to minimize suffering from CRPS would certainly be appreciated by many patients and their loved ones.
Disks around hot stars in the Trifid nebula

We report on mid-IR observations of the central region in the Trid nebula, carried out with ISOCAM in several broad-band infrared lters and in the low resolution spectroscopic mode provided by the circular variable lter. Analysis of the emission indicates the presence of a hot dust component (500 to 1000 K) and a warm dust component at lower temperatures (150 200 K) around several members of the cluster exciting the HII region, and other stars undetected at optical wavelengths. Complementary VLA observations suggest that the mid-IR emission could arise from a dust cocoon or a circumstellar disk, evaporated under the ionization of the central source and the exciting star of the nebula. In several sources the 9:7 m silicate band is seen in emission. One young stellar source shows indications of crystalline silicates in the circumstellar dust.
An X-ray view of the active nucleus in NGC 4258

XMM-Newton observed the Seyfert 1.9 galaxy NGC 4258 in December 2000. At energies above 2 keV a hard nuclear point source is resolved that can be tted by a highly absorbed power-law spectrum (NH= (8:0 0:4) 10 22 cm 2 , photon index 1:64 0:08) with an unabsorbed luminosity of 7.510 40 erg s 1 in the (2{ 10) keV band. No narrow iron K emission line is detected (90% upper limit of equivalent widthEW 40 eV). The nuclear emission flux was observed to remain constant over the observation. A short archival Chandra observation taken in March 2000 further constrains the hard emission to a point source coincident with the radio nucleus. A point source3 00 southwest of the nucleus does not contribute signicantly. Spectral results of the Chandra nuclear source are comparable (within the limited statistics) to the XMM-Newton parameters. The comparison of our iron line upper limit with reported detections indicates variability of the line EW. These results can be explained by the relatively low nuclear absorption of NGC 4258 (which is in the range expected for its intermediate Seyfert type) and some variability of the absorbing material. Reflection components as proposed to explain the large iron line EW of highly absorbed Seyfert 2 galaxies and/or variations in the accretion disk are however imposed by the time variability of the iron line flux.
RAD sequencing resolves fine-scale population structure in a benthic invertebrate: implications for understanding phenotypic plasticity

The field of molecular ecology is transitioning from the use of small panels of classical genetic markers such as microsatellites to much larger panels of single nucleotide polymorphisms (SNPs) generated by approaches like RAD sequencing. However, few empirical studies have directly compared the ability of these methods to resolve population structure. This could have implications for understanding phenotypic plasticity, as many previous studies of natural populations may have lacked the power to detect genetic differences, especially over micro-geographic scales. We therefore compared the ability of microsatellites and RAD sequencing to resolve fine-scale population structure in a commercially important benthic invertebrate by genotyping great scallops (Pecten maximus) from nine populations around Northern Ireland at 13 microsatellites and 10 539 SNPs. The shells were then subjected to morphometric and colour analysis in order to compare patterns of phenotypic and genetic variation. We found that RAD sequencing was superior at resolving population structure, yielding higher Fst values and support for two distinct genetic clusters, whereas only one cluster could be detected in a Bayesian analysis of the microsatellite dataset. Furthermore, appreciable phenotypic variation was observed in size-independent shell shape and coloration, including among localities that could not be distinguished from one another genetically, providing support for the notion that these traits are phenotypically plastic. Taken together, our results suggest that RAD sequencing is a powerful approach for studying population structure and phenotypic plasticity in natural populations.
Facial expression recognition based on two dimensional feature extraction

In this paper, approaches to facial expression recognition based on two dimension methods are studied. 2D expression feature extraction methods include 2DPCA, 2DLDA and generalized low rank approximation of matrices (GLRAM) which are usually used in face recognition or data compression. After expression features are extracted, support vector machine classifier is used for expression classification. Extensive expression recognition experiments are carried out on Japanese female facial expression database (JAFFE) to study the influence of feature dimension on recognition ratio and the results are also compared with that of the tradition 1D feature extraction methods such as PCA and LDA. Experiment results show that 2D methods are effective in expression recognition application and usually outperform 1D methods.
Stochastic Variance-reduced Gradient Descent for Low-rank Matrix Recovery from Linear Measurements

We study the problem of estimating low-rank matrices from linear measurements (a.k.a., matrix sensing) through nonconvex optimization. We propose an efficient stochastic variance reduced gradient descent algorithm to solve a nonconvex optimization problem of matrix sensing. Our algorithm is applicable to both noisy and noiseless settings. In the case with noisy observations, we prove that our algorithm converges to the unknown low-rank matrix at a linear rate up to the minimax optimal statistical error. And in the noiseless setting, our algorithm is guaranteed to linearly converge to the unknown low-rank matrix and achieves exact recovery with optimal sample complexity. Most notably, the overall computational complexity of our proposed algorithm, which is defined as the iteration complexity times per iteration time complexity, is lower than the state-of-the-art algorithms based on gradient descent. Experiments on synthetic data corroborate the superiority of the proposed algorithm over the state-of-the-art algorithms.
Dermal Exposure to Jet Fuel JP-8 Significantly Contributes to the Production of Urinary Naphthols in Fuel-Cell Maintenance Workers

Jet propulsion fuel 8 (JP-8) is the major jet fuel used worldwide and has been recognized as a major source of chemical exposure, both inhalation and dermal, for fuel-cell maintenance workers. We investigated the contributions of dermal and inhalation exposure to JP-8 to the total body dose of U.S. Air Force fuel-cell maintenance workers using naphthalene as a surrogate for JP-8 exposure. Dermal, breathing zone, and exhaled breath measurements of naphthalene were obtained using tape-strip sampling, passive monitoring, and glass bulbs, respectively. Levels of urinary 1- and 2-naphthols were determined in urine samples and used as biomarkers of JP-8 exposure. Multiple linear regression analyses were conducted to investigate the relative contributions of dermal and inhalation exposure to JP-8, and demographic and work-related covariates, to the levels of urinary naphthols. Our results show that both inhalation exposure and smoking significantly contributed to urinary 1-naphthol levels. The contribution of dermal exposure was significantly associated with levels of urinary 2-naphthol but not with urinary 1-naphthol among fuel-cell maintenance workers who wore supplied-air respirators. We conclude that dermal exposure to JP-8 significantly contributes to the systemic dose and affects the levels of urinary naphthalene metabolites. Future work on dermal xenobiotic metabolism and toxicokinetic studies are warranted in order to gain additional knowledge on naphthalene metabolism in the skin and the contribution to systemic exposure.