Miracle-dz/UniFAR-FTUs huggingface dataset:
Finiteness of redundancy, regret, Shtarkov sums, and Jeffreys integrals in exponential families

Disclosed herein are herbicidal pyridine compounds substituted at the 2- or 6-position with an OR2 moiety where R2 is hydrogen, lower alkyl, halomethyl, lower cyanoalkyl, alkenyl or alkynyl, as well as herbicidal compositions and herbicidal use of these compounds.
Seven-Day Bismuth-based Quadruple Therapy as an Initial Treatment for Helicobacter pylori Infection in a High Metronidazole Resistant Area.

BACKGROUND The prevalence of metronidazole-resistant H. pylori is almost 50% in Thailand which severely limits the use of this drug for eradication therapy. The aims of this study were to evaluate the efficacy and safety profiles of 7-day bismuth-based quadruple therapy including metronidazole as an initial treatment for H. pylori infection in a high metronidazole resistance area. MATERIALS AND METHODS This study was performed at Thammasat University Hospital and King Chulalongkorn Memorial Hospital during January 2009 to October 2010. Patients with non-ulcer dyspepsia (NUD) with active H. pylori infection were assigned to receive seven days of quadruple therapy (pantoprazole 40 mg bid, bismuth subsalicylate 1,048 mg bid, amoxicillin 1 gm bid and metronidazole 400 mg tid). H. pylori infection was defined as positive H. pylori culture or two positive tests (rapid urease test and histology). Antibiotic susceptibility test for metronidazole by Epsilometer test (E-test) was performed in all positive cultures. At least four weeks after treatment, 13C urea breath test (13C-UBT) was performed to confirm H. pylori eradication. RESULTS A total of 114 patients were enrolled in this study, 50 males and 64 females with a mean age of 49.8 years. All 114 patients had a diagnosis of NUD. Overall eradication as confirmed by negative 13C-UBT was achieved in 94 out of 114 patients (82.5%). 44 patients had positive cultures and success for E-test. In vitro metronidazole resistance was observed in 22/44 (50%) patients. Eradication rate in patients with metronidazole resistant strains was 16/22 (72.7%) and 20/22 (90.1%) with metronidazole sensitive strains (72.7% vs 90.1%, p-value=0.12; OR=3.75 [95%CI=0.6-31.5]). Minor adverse reactions included nausea, bitter taste, diarrhea and black stools but none of the patients dropped out from the study. CONCLUSIONS Initial treatment with 7-day bismuth-based quadruple therapy including metronidazole, amoxycillin and pantoprazole is highly effective and well tolerated for metronidazole-sensitive H. pylori infections. However, the efficacy markedly decline with metronidazole resistance. Longer duration of this regimen might be required to improve the eradication rate and larger multi-center studies are needed to confirm this hypothesis.
Prognostic use of cardiac troponin T and troponin I in patients with heart failure.

BACKGROUND Troponin T (cTnT) and troponin I (cTnI) are present in the sera of some heart failure (HF) patients and have potential importance as prognostic markers. OBJECTIVE To prospectively evaluate the prognostic value of cTnT and cTnI in well-characterized HF patients and clarify their relationship to other clinical markers of HF severity. METHODS cTnT and cTnI were measured in 78 HF patients (45 inpatients, 33 outpatients) who were followed up prospectively for 12 months. RESULTS Plasma cTnT (> or =0.02 ng/mL) and cTnI (> or =0.3 ng/mL) were detected in 51% and 46% of patients, respectively. These patients were more likely to be inpatients (70% versus 45% for cTnT, 75% versus 43% for cTnI, P<0.05 for both), have a higher plasma creatinine (153 versus 119 micromol/L for cTnT; 157 versus 118 micromol/L for cTnI, P<0.05) and lower plasma sodium (134 versus 138 mmol/L for both, P<0.05). At 12 months, they were more likely to have died or undergone cardiac transplantation (41% versus 14%, P=0.01 for cTnT; 43% versus 15%, P=0.004 for cTnI). After adjustment for New York Heart Association class, plasma sodium and inpatient status, a significant association with events was still evident for both troponins. CONCLUSIONS Both cTnT and cTnI are strongly associated with other clinical indicators of HF severity and remain independent predictors of prognosis after adjustment for these factors. These results indicate a potential role for cTnT and cTnI in the clinical management of HF patients.
Causal Status as a Determinant of Feature Centrality

One of the major problems in categorization research is the lack of systematic ways of constraining feature weights. We propose one method of operationalizing feature centrality, a causal status hypothesis which states that a cause feature is judged to be more central than its effect feature in categorization. In Experiment 1, participants learned a novel category with three characteristic features that were causally related into a single causal chain and judged the likelihood that new objects belong to the category. Likelihood ratings for items missing the most fundamental cause were lower than those for items missing the intermediate cause, which in turn were lower than those for items missing the terminal effect. The causal status effect was also obtained in goodness-of-exemplar judgments (Experiment 2) and in free-sorting tasks (Experiment 3), but it was weaker in similarity judgments than in categorization judgments (Experiment 4). Experiment 5 shows that the size of the causal status effect is moderated by plausibility of causal relations, and Experiment 6 shows that effect features can be useful in retrieving information about unknown causes. We discuss the scope of the causal status effect and its implications for categorization research.
PCR-Based Simple Subgrouping Is Validated for Classification of Gliomas and Defines Negative Prognostic Copy Number Aberrations in IDH Mutant Gliomas

Genetic subgrouping of gliomas has been emphasized recently, particularly after the finding of isocitrate dehydrogenase 1 (IDH1) mutations. In a previous study, we investigated whole-chromosome copy number aberrations (CNAs) of gliomas and have described genetic subgrouping based on CNAs and IDH1 mutations. Subsequently, we classified gliomas using simple polymerase chain reaction (PCR)-based methods to improve the availability of genetic subgrouping. We selected IDH1/2 and TP53 as markers and analyzed 237 adult supratentorial gliomas using Sanger sequencing. Using these markers, we classified gliomas into three subgroups that were strongly associated with patient prognoses. These included IDH mutant gliomas without TP53 mutations, IDH mutant gliomas with TP53 mutations, and IDH wild-type gliomas. IDH mutant gliomas without TP53 mutations, which mostly corresponded to gliomas carrying 1p19q co-deletions, showed lower recurrence rates than the other 2 groups. In the other high-recurrence groups, the median progression-free survival (PFS) and overall survival (OS) of patients with IDH mutant gliomas with TP53 mutations were significantly longer than those of patients with IDH wild-type gliomas. Notably, most IDH mutant gliomas with TP53 mutations had at least one of the CNAs +7q, +8q, −9p, and −11p. Moreover, IDH mutant gliomas with at least one of these CNAs had a significantly worse prognosis than did other IDH mutant gliomas. PCR-based mutation analyses of IDH and TP53 were sufficient for simple genetic diagnosis of glioma that were strongly associated with prognosis of patients and enabled us to detect negative CNAs in IDH mutant gliomas.
Bankruptcy and the Market for Mortgage and Home Improvement Loans

This paper investigates the relationship between bankruptcy exemptions and the availability of credit for mortgage and home improvement loans. We develop a combined model of debtors' decisions to file for bankruptcy and to default on their mortgages and show that the theory predicts positive relationships between both the homestead and personal property exemption levels and the probability of borrowers being denied mortgage (secured) and home improvement loans. We test these predictions empirically and find strong and statistically significant support when evidence from cross-state variation in bankruptcy exemption levels is used. Applicants for mortgages are 2 percentage points more likely to be turned down for mortgages and 5 percentage points more likely to be turned down for home improvement loans if they live in states with unlimited rather than low homestead exemptions. These relationships also hold when we introduce state fixed effects into the model.
The axiomatic approach to the problem of sharing the revenue from bundled pricing

We explore in this paper the axiomatic approach to the problem of sharing the revenue from bundled pricing. We formalize two models for this problem on the grounds of two different informational bases. In both models, we provide axiomatic rationale for natural rules to solve the problem. We, nonetheless, obtain drastic differences under each scenario, which highlights the importance of setting the appropriate informational basis of the problem.
Quality of life in neurologically healthy children with urinary incontinence

Aim: To bring forward the arguments for active treatment of urine incontinence in otherwise healthy children, a quality‐of‐life (QoL) study was performed. Subjects and methods: A self‐rating QoL questionnaire, child‐adjusted and validated, was completed by 120 neurologically healthy children, aged 6–16 y, with urinary incontinence. Another 239 age‐matched children made up a control group. The two groups were compared both totally and in age‐related subgroups (6–8, 9–12, >12 y) concerning the index for all questions, for universal parts (without questions dealing with incontinence) as well as for specific key domains. Results: The patient group had a significantly lower index than the control group both with and without items related to incontinence (p <0.0001). Social situation, self‐esteem and self‐confidence were most influenced, particularly in the youngest children. Thirty‐one children (13%) of the control group reported incontinence and did not score their QoL as good as their continent peers but better than the study patients.
The Intelligent Welding Gun : Augmented Reality for Experimental Vehicle Construction

This chapter presents the prototypical design and implementation of an Intelligent Welding Gun to help welders in the automotive industry shoot studs with high precision in experimental vehicles. A presentation of the stud welding scenario and the identified system requirements is followed by a thorough exploration of the design space of potential system setups, analyzing the feasibility of different options to place sensors, displays and landmarks in the work area. The setup yielding the highest precision for stud welding purposes is the Intelligent Welding Gun – a regular welding gun with a display attachment, a few buttons for user interactions, and reflective markers to track the gun position from stationary cameras. While welders operate and move the gun, the display shows threedimensional stud locations on the car frame relative to the current gun position. Navigational metaphors, such as notch and bead and a compass, are used to help welders place the gun at the planned stud positions with the required precision. The setup has been tested by a number of welders. It shows significant time improvements over the traditional stud welding process. It is currently in the process of being modified and installed for productional use.
Sound Classification in a Smart Room Environment: an Approach using GMM and HMM Methods

Because of cost or convenience reasons, patients or elderly people would be hospitalized at home and smart information systems would be needed in order to assist human operators. In this case, position and physiologic sensors give already numerous informations, but there are few studies for sound use in patient's habitation. However, sound classification and speech recognition may greatly increase the versatility of such a system: this will be provided by detecting short sentences or words which could characterize a distress situation for the patient. Analysis and classification of sounds emitted in patient's habitation may be useful for patient's activity monitoring. GMMs and HMMs are well suited for sound classification. Until now, GMMs are frequently used for sound classification in smart rooms because of their low computational costs, but HMMs should allow a finer analysis: indeed the use of 3 states HMMs should allow better performances by taking into account the variation of the signal according to time. For this framework a new sound corpus was recorded in experimental conditions. This corpus includes 8 sound classes useful for our application. The choice of needed acoustical features and the two approaches are presented. Then an evaluation is made with the initial corpus and with additional experimental noise. The obtained results are compared. At the end of this framework a segmentation module is presented. This module has the ability of extracting isolated sounds in a record by the means of a wavelet filtering method which allows the extraction in noisy conditions.
Cationic Amino Acids Specific Biomimetic Silicification in Ionic Liquid: A Quest to Understand the Formation of 3-D Structures in Diatoms

The intricate, hierarchical, highly reproducible, and exquisite biosilica structures formed by diatoms have generated great interest to understand biosilicification processes in nature. This curiosity is driven by the quest of researchers to understand nature's complexity, which might enable reproducing these elegant natural diatomaceous structures in our laboratories via biomimetics, which is currently beyond the capabilities of material scientists. To this end, significant understanding of the biomolecules involved in biosilicification has been gained, wherein cationic peptides and proteins are found to play a key role in the formation of these exquisite structures. Although biochemical factors responsible for silica formation in diatoms have been studied for decades, the challenge to mimic biosilica structures similar to those synthesized by diatoms in their natural habitats has not hitherto been successful. This has led to an increasingly interesting debate that physico-chemical environment surrounding diatoms might play an additional critical role towards the control of diatom morphologies. The current study demonstrates this proof of concept by using cationic amino acids as catalyst/template/scaffold towards attaining diatom-like silica morphologies under biomimetic conditions in ionic liquids.
Role of the Stable Signal Peptide and Cytoplasmic Domain of G2 in Regulating Intracellular Transport of the Junín Virus Envelope Glycoprotein Complex

ABSTRACT Enveloped viruses utilize the membranous compartments of the host cell for the assembly and budding of new virion particles. In this report, we have investigated the biogenesis and trafficking of the envelope glycoprotein (GP-C) of the Junín arenavirus. The mature GP-C complex is unusual in that it retains a stable signal peptide (SSP) as an essential component in association with the typical receptor-binding (G1) and transmembrane fusion (G2) subunits. We demonstrate that, in the absence of SSP, the G1-G2 precursor is restricted to the endoplasmic reticulum (ER). This constraint is relieved by coexpression of SSP in trans, allowing transit of the assembled GP-C complex through the Golgi and to the cell surface, the site of arenavirus budding. Transport of a chimeric CD4 glycoprotein bearing the transmembrane and cytoplasmic domains of G2 is similarly regulated by SSP association. Truncations to the cytoplasmic domain of G2 abrogate SSP association yet now permit transport of the G1-G2 precursor to the cell surface. Thus, the cytoplasmic domain of G2 is an important determinant for both ER localization and its control through SSP binding. Alanine mutations to either of two dibasic amino acid motifs in the G2 cytoplasmic domain can also mobilize the G1-G2 precursor for transit through the Golgi. Taken together, our results suggest that SSP binding masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP-C complex is transported for virion assembly. This quality control process points to an important role of SSP in the structure and function of the arenavirus envelope glycoprotein.
Sustainable water deliveries from the Colorado River in a changing climate

The Colorado River supplies water to 27 million users in 7 states and 2 countries and irrigates over 3 million acres of farmland. Global climate models almost unanimously project that human-induced climate change will reduce runoff in this region by 10–30%. This work explores whether currently scheduled future water deliveries from the Colorado River system are sustainable under different climate-change scenarios. If climate change reduces runoff by 10%, scheduled deliveries will be missed ≈58% of the time by 2050. If runoff reduces 20%, they will be missed ≈88% of the time. The mean shortfall when full deliveries cannot be met increases from ≈0.5–0.7 billion cubic meters per year (bcm/yr) in 2025 to ≈1.2–1.9 bcm/yr by 2050 out of a request of ≈17.3 bcm/yr. Such values are small enough to be manageable. The chance of a year with deliveries <14.5 bcm/yr increases to 21% by midcentury if runoff reduces 20%, but such low deliveries could be largely avoided by reducing scheduled deliveries. These results are computed by using estimates of Colorado River flow from the 20th century, which was unusually wet; if the river reverts to its long-term mean, shortfalls increase another 1–1.5 bcm/yr. With either climate-change or long-term mean flows, currently scheduled future water deliveries from the Colorado River are not sustainable. However, the ability of the system to mitigate droughts can be maintained if the various users of the river find a way to reduce average deliveries.
IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development

We asked whether the hypoxia-regulated factor, insulin-like growth factor binding protein-3 (IGFBP3), could modulate stem cell factor receptor (c-kit+), stem cell antigen-1 (sca-1+), hematopoietic stem cell (HSC), or CD34+ endothelial precursor cell (EPC) function. Exposure of CD34+ EPCs to IGFBP3 resulted in rapid differentiation into endothelial cells and dose-dependent increases in cell migration and capillary tube formation. IGFBP3-expressing plasmid was injected into the vitreous of neonatal mice undergoing the oxygen-induced retinopathy (OIR) model. In separate studies, GFP-expressing HSCs were transfected with IGFBP3 plasmid and injected into the vitreous of OIR mice. Administering either IGFBP3 plasmid alone or HSCs transfected with the plasmid resulted in a similar reduction in areas of vasoobliteration, protection of the developing vasculature from hyperoxia-induced regression, and reduction in preretinal neovascularization compared to control plasmid or HSCs transfected with control plasmid. In conclusion, IGFBP3 mediates EPC migration, differentiation, and capillary formation in vitro. Targeted expression of IGFBP3 protects the vasculature from damage and promotes proper vascular repair after hyperoxic insult in the OIR model. IGFBP3 expression may represent a physiological adaptation to ischemia and potentially a therapeutic target for treatment of ischemic conditions.
Effect of protein intake during gestation on mammary development of primiparous sows.

The effect of protein intake during gestation on mammary development was evaluated using 17 Landrace x Yorkshire gilts. On d 25 of gestation, gilts were allocated to dietary treatments consisting of levels of protein to achieve lysine intakes of approximately 4, 8, or 16 g/d. Diets provided similar amounts of ME (6.5 Mcal/d) and all other nutrients. On d 105 of gestation, gilts were bled through venipuncture to collect blood samples for analyses of blood metabolites (glucose, NEFA, blood urea nitrogen [BUN]), and metabolic hormones (insulin and IGF-I). Gilts were slaughtered between d 105 and 110 of gestation for complete collection of mammary glands. All mammary glands were carefully removed and separated from each other along the midline. One side was weighed, immediately frozen in liquid nitrogen, and stored at -70 degrees C until further processing. Frozen glands were sliced, and parenchymal tissue was separated and pooled across glands within sow, homogenized, and analyzed for DNA, RNA, and protein concentrations as indices of mammary development. Results showed no effect (P > . 10) of level of lysine intake on amount of mammary parenchymal tissue or on concentration or total amount of DNA, RNA, and protein. This experiment did not detect differences between treatments in mammary development as measured by nucleic acids and protein. Therefore, there was no effect of the amount of protein intake by gilts on mammary development. Regression analyses failed to detect any relationships between measures of mammary development and levels of metabolites or metabolic hormones.
A mechanism for the destruction of pinosomes in cultured fibroblasts. Piranhalysis

The destruction of large pinosomes was examined with phase-contrast microscopy in cultured mouse fibroblasts. In areas of rapid pinosome breakdown, lysosomes were observed to repeatedly collide with pinosomes without fusing, tearing off small pieces until the pinosomes became smaller and denser. This segmentation of pinosomes by lysosomal collision has been named "piranhalysis. "
Causal Relationships between Perceived Enjoyment and Perceived Ease of Use: An Alternative Approach

Identifying causal relationships is an important aspect of scientific inquiry. Causal relationships help us to infer, predict, and plan. This research investigates the causal relationships between two constructs, perceived enjoyment (PE) and perceived ease of use (PEOU), within the nomological net of user technology acceptance. PE has been theorized and empirically validated as either an antecedent or a consequence of PEOU. We believe that there are two reasons that account for this ambiguity the conceptual coupling of PE and PEOU and the limitations of covariance-based statistical methods. Accordingly, we approach this inconsistency by providing more theoretical reasoning and employing an alternative statistical method, namely Cohen’s path analysis. Specifically, as suggested by previous research on the difference between utilitarian and hedonic systems, we propose the conditional dominance of causal directions. Empirical results from two studies using different technologies and user samples support the theoretical claim that the PE∆PEOU causal direction outweighs the PEOU∆PE direction for utilitarian systems. There are both theoretical and the methodical contributions of this research. The approach applied in this research can be generalized to study causal relationships between conceptually coupled variables, which otherwise may be overlooked by confirmatory methods. We encourage researchers to pay attention to causal directions in addition to causal connectedness.