Miracle-dz/UniFAR-FTUs huggingface dataset:
Idiopathic non-cirrhotic intrahepatic portal hypertension in the West: a re-evaluation in 28 patients

Background: Non-cirrhotic portal hypertension of unknown cause is a poorly understood condition attributed to obstructive portal venopathy. Aim: To reassess the manifestations, course, and causes, with special attention to thrombosis. Methods: Analysis of a cohort of 28 patients. Results: Gastrointestinal bleeding occurred in 11 patients. Liver failure developed at the time of concurrent disease in eight patients, including all four patients who died. Portal vein thrombosis developed in 13 patients. A prothrombotic disorder was found in 12 of 23 fully investigated patients. Hepatoportal sclerosis was observed in 11 patients (with associated perisinusoidal fibrosis and/or nodular regenerative hyperplasia in six); periportal fibrosis, perisinusoidal fibrosis, nodular regenerative hyperplasia, or a combination thereof were observed in other patients. A morphometric evaluation showed an increased number of portal vessels in patients with hepatoportal sclerosis. There was no relation between pathological results and haemodynamic findings or prothrombotic disorders. Conclusions: Outcome was related to associated conditions. Overlap in pathological, haemodynamic, and causal features suggests a single entity, with prothrombotic disorders as major causal factors, and injury to sinusoids as well as to portal venules as the primary mechanism. Activated coagulation could mediate vascular injury in the absence of thrombosis. Anticoagulation should be considered.
Cross-Modal Interactions between Audition, Touch, and Vision in Endogenous Spatial Attention: ERP Evidence on Preparatory States and Sensory Modulations

Recent behavioral and event-related brain potential (ERP) studies have revealed cross-modal interactions in endogenous spatial attention between vision and audition, plus vision and touch. The present ERP study investigated whether these interactions reflect supramodal attentional control mechanisms, and whether similar cross-modal interactions also exist between audition and touch. Participants directed attention to the side indicated by a cue to detect infrequent auditory or tactile targets at the cued side. The relevant modality (audition or touch) was blocked. Attentional control processes were reflected in systematic ERP modulations elicited during cued shifts of attention. An anterior negativity contralateral to the cued side was followed by a contralateral positivity at posterior sites. These effects were similar whether the cue signaled which side was relevant for audition or for touch. They also resembled previously observed ERP modulations for shifts of visual attention, thus implicating supramodal mechanisms in the control of spatial attention. Following each cue, single auditory, tactile, or visual stimuli were presented at the cued or uncued side. Although stimuli in task-irrelevant modalities could be completely ignored, visual and auditory ERPs were nevertheless affected by spatial attention when touch was relevant, revealing cross-modal interactions. When audition was relevant, visual ERPs, but not tactile ERPs, were affected by spatial attention, indicating that touch can be decoupled from cross-modal attention when task-irrelevant.
Influence of Cultural Meaning System and Socioeconomic Change on Indecisiveness in Three Cultures

Psychologists have debated two external factors that influence human behaviors: current socioeconomic changes and historically shared cultural meaning systems. By conducting triangular comparisons among Hong Kong Chinese, mainland Chinese, and European Canadians, the current study examined whether these two factors differentially influence people’s indecisiveness. We found that (a) Hong Kong Chinese participants’ level of indecisiveness was highest, and there were no differences between the two other groups; (b) dialectical beliefs facilitated participants’ indecisiveness whereas optimism toward the future attenuated it across cultures and both factors explained cultural variations in indecisiveness; and (c) different from European Canadians’ optimism, optimism about the future promoted by perception of current rapid societal change made mainland Chinese more decisive. The importance of within-region analyses to disentangle varying factors in decision-making processes is discussed.
Comparative Phylogenetic Studies on Schistosoma japonicum and Its Snail Intermediate Host Oncomelania hupensis: Origins, Dispersal and Coevolution

Background Schistosoma japonicum causes major public health problems in China and the Philippines; this parasite, which is transmitted by freshwater snails of the species Oncomelania hupensis, causes the disease intestinal schistosomiasis in humans and cattle. Researchers working on Schistosoma in Africa have described the relationship between the parasites and their snail intermediate hosts as coevolved or even as an evolutionary arms race. In the present study this hypothesis of coevolution is evaluated for S. japonicum and O. hupensis. The origins and radiation of the snails and the parasite across China, and the taxonomic validity of the sub-species of O. hupensis, are also assessed. Methodology/Principal Findings The findings provide no evidence for coevolution between S. japonicum and O. hupensis, and the phylogeographical analysis suggests a heterochronous radiation of the parasites and snails in response to different palaeogeographical and climatic triggers. The results are consistent with a hypothesis of East to West colonisation of China by Oncomelania with a re-invasion of Japan by O. hupensis from China. The Taiwan population of S. japonicum appears to be recently established in comparison with mainland Chinese populations. Conclusions/Significance The snail and parasite populations of the western mountain region of China (Yunnan and Sichuan) appear to have been isolated from Southeast Asian populations since the Pleistocene; this has implications for road and rail links being constructed in the region, which will breach biogeographical barriers between China and Southeast Asia. The results also have implications for the spread of S. japonicum. In the absence of coevolution, the parasite may more readily colonise new snail populations to which it is not locally adapted, or even new intermediate host species; this can facilitate its dispersal into new areas. Additional work is required to assess further the risk of spread of S. japonicum.
Mentoring in Health Services Management: Reflections on an Evolving Training Ground

Since the University of Chicago Health Management program was first initiated in 1932, programs and health delivery organizations have dealt with the issue of how to best provide a meaningful transition from academia to entry-level management. Today, new challenges face the same old questions: New federal legislation and increased demand for a finite supply of services cause increased revenue and expense pressures and result in the need for a higher performance level by a well-coordinated management team. In addressing these challenges, mentoring is an essential requirement for survival and success in health services. The long-term success of future practitioners will require both an understanding and incorporation of mentoring in their skill set. The University of Virginia Medical Center recently sponsored a health management education summit to examine the role of mentoring in health services administration education. Leading the program were John Westerman, former interim president of Association of University Programs in Healthcare Administration and chief executive officer emeritus of the University of Minnesota Health System, and R. Edward Howell, chief executive officer of the University of Virginia Medical Center. Summit participants included individuals who had completed administrative fellowship training programs. What follows is a review of the discussions during the summit, including a valuation of the health services fellowship as a learning experience as well as structure and essential elements of administrative mentoring programs.
Host Phylogeny Determines Viral Persistence and Replication in Novel Hosts

Pathogens switching to new hosts can result in the emergence of new infectious diseases, and determining which species are likely to be sources of such host shifts is essential to understanding disease threats to both humans and wildlife. However, the factors that determine whether a pathogen can infect a novel host are poorly understood. We have examined the ability of three host-specific RNA-viruses (Drosophila sigma viruses from the family Rhabdoviridae) to persist and replicate in 51 different species of Drosophilidae. Using a novel analytical approach we found that the host phylogeny could explain most of the variation in viral replication and persistence between different host species. This effect is partly driven by viruses reaching a higher titre in those novel hosts most closely related to the original host. However, there is also a strong effect of host phylogeny that is independent of the distance from the original host, with viral titres being similar in groups of related hosts. Most of this effect could be explained by variation in general susceptibility to all three sigma viruses, as there is a strong phylogenetic correlation in the titres of the three viruses. These results suggest that the source of new emerging diseases may often be predictable from the host phylogeny, but that the effect may be more complex than simply causing most host shifts to occur between closely related hosts.
BRIDGING THE GENDER GAP IN ENTREPRENEURSHIP: AN EMPIRICAL ANALYSIS

There is no gender difference between success in establishing a business once both males and females have the same preference to self-employment and attempts towards establishing a new business. However, the gender gap tends to be huge when it comes to individual preferences and attempts to start up an entrepreneurial activity. In this study, we empirically estimate the role of inequality in individual and country attributes between man and woman in the bridging the gender entrepreneurship gap. Using Oaxaca-type decomposition and its extensions, we found that differences in both individual as well as country characteristics largely favor males, while the former play greater role in explaining the gender gap. Empirical results also show differences in return to measured characteristics favor males. Nevertheless, a portion of gender gap that is unexplained by the differences in these characteristics and their coefficients (or return) could still indicate gender discrimination.
Factors adversely associated with breast feeding in New Zealand

Control data from 1529 infants studied in a multicentre case‐control study of sudden infant death in New Zealand were analysed to identify factors that might hinder the establishment and duration of breast feeding. Although 1300 infants (85%) were exclusively breast‐fed at discharge from the obstetric hospital, this fell to 940 (61%) by 4 weeks. Logistic regression was used to identify factors that might adversely influence breast feeding ‘at discharge’,‘at 4 weeks’ and the overall ‘duration’ of breast feeding.
Your Voice Assistant is Mine: How to Abuse Speakers to Steal Information and Control Your Phone

Previous research about sensor based attacks on Android platform focused mainly on accessing or controlling over sensitive components, such as camera, microphone and GPS. These approaches obtain data from sensors directly and need corresponding sensor invoking permissions. This paper presents a novel approach (GVS-Attack) to launch permission bypassing attacks from a zero-permission Android application (VoicEmployer) through the phone speaker. The idea of GVS-Attack is to utilize an Android system built-in voice assistant module -- Google Voice Search. With Android Intent mechanism, VoicEmployer can bring Google Voice Search to foreground, and then plays prepared audio files (like "call number 1234 5678") in the background. Google Voice Search can recognize this voice command and perform corresponding operations. With ingenious design, our GVS-Attack can forge SMS/Email, access privacy information, transmit sensitive data and achieve remote control without any permission. Moreover, we found a vulnerability of status checking in Google Search app, which can be utilized by GVS-Attack to dial arbitrary numbers even when the phone is securely locked with password. A prototype of VoicEmployer has been implemented to demonstrate the feasibility of GVS-Attack. In theory, nearly all Android (4.1+) devices equipped with Google Services Framework can be affected by GVS-Attack. This study may inspire application developers and researchers to rethink that zero permission doesn't mean safety and the speaker can be treated as a new attack surface.
How can managers promote salespeople’s person-job fit? The effects of cooperative learning and perceived organizational support

Purpose – This paper aims to examine the impact of salespeople’s subjective person-job fit on the salespeople’s intention to quit. Moreover, this study further investigates how the subjective person – job fit could be influenced by the cooperative learning and support in the organization. Person-job fit is an important issue for salespeople’s career development. However, the antecedents of salespeople’s person-job fit seem to have been under-investigated in the management literature. Design/methodology/approach – A questionnaire survey is used as a research instrument, and Taiwan’s full-time life insurance salespeople took part in the investigation. The hypotheses were tested by using partial least squares and structural equation modeling tool (SmartPLS 2.0). Findings – The results confirmed that poor subjective person-job fit would significantly increase the salespeople’s intention to quit. Yet, the results also suggested that cooperative learning and organizational support are the mechanisms that reduce.
Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation

Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels mediate pacemaker currents in the atrium. The microRNA (miR) families miR-1 and miR-133 regulate the expression of multiple genes involved in myocardial function, including HCN channels. It was hypothesized that age-dependent changes in HCN2, HCN4, miR-1 and miR-133 expression may contribute to age-associated atrial fibrillation, and therefore the correlation between expression levels, among adult (≤65 years) and aged patients (≥65 years), and sinus rhythm was determined. Right atrial appendage samples were collected from 60 patients undergoing coronary artery bypass grafting. Reverse transcription-quantitative polymerase chain reaction (PCR) and western blot analyses were performed in order to determine target RNA and protein expression levels. Compared with aged patients with sinus rhythm, aged patients with atrial fibrillation exhibited significantly higher HCN2 and HCN4 channel mRNA and protein expression levels (P<0.05), but significantly lower expression levels of miR-1 and miR-133 (P<0.05). In addition, aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR-1 and -133 (P<0.05), compared with those of adult patients with sinus rhythm. Expression levels of HCN2 and HCN4 increased with age, and a greater increase was identified in patients with age-associated atrial fibrillation compared with that in those with aged sinus rhythm. These electrophysiological changes may contribute to the induction of ectopic premature beats that trigger atrial fibrillation.
Gaming at a LAN event: the social context of playing video games

An exploratory survey was undertaken about the appeal of playing video games at a Local Area Network (LAN) event where personal computers are linked in order to play both face-to-face and online. First, we wanted to know who the visitors of a LAN event were, because there is hardly any research available about this class of gamers. Second, we wanted to know why they participated in a LAN event. The survey showed that LAN gamers were almost exclusively male, with a mean age of 19.5 years. They devoted about 2.6 hours each day to gaming. They were motivated by social contact and a need to know more about games. The competition motive was third in the total sample. A subgroup of heavy gamers obtained a higher score on competition. This article emphasizes the importance of the social context of gaming and interprets its results as a nuance of the stereotype of the solitary, adolescent gamer.
Certifiably Optimal Low Rank Factor Analysis

Factor Analysis (FA) is a technique of fundamental importance that is widely used in classical and modern multivariate statistics, psychometrics and econometrics. In this paper, we revisit the classical rank-constrained FA problem, which seeks to approximate an observed covariance matrix ($\boldsymbol\Sigma$), by the sum of a Positive Semidefinite (PSD) low-rank component ($\boldsymbol\Theta$) and a diagonal matrix ($\boldsymbol\Phi$) (with nonnegative entries) subject to $\boldsymbol\Sigma - \boldsymbol\Phi$ being PSD. We propose a flexible family of rank-constrained, nonlinear Semidefinite Optimization based formulations for this task. We introduce a reformulation of the problem as a smooth optimization problem with convex compact constraints and propose a unified algorithmic framework, utilizing state of the art techniques in nonlinear optimization to obtain high-quality feasible solutions for our proposed formulation. At the same time, by using a variety of techniques from discrete and global optimization, we show that these solutions are certifiably optimal in many cases, even for problems with thousands of variables. Our techniques are general and make no assumption on the underlying problem data. The estimator proposed herein, aids statistical interpretability, provides computational scalability and significantly improved accuracy when compared to current, publicly available popular methods for rank-constrained FA. We demonstrate the effectiveness of our proposal on an array of synthetic and real-life datasets. To our knowledge, this is the first paper that demonstrates how a previously intractable rank-constrained optimization problem can be solved to provable optimality by coupling developments in convex analysis and in discrete optimization.
Characterization of a Bacillus anthracis spore coat-surface protein that influences coat-surface morphology.

Bacterial spores are encased in a multilayered proteinaceous shell, called the coat. In many Bacillus spp. , the coat protects against environmental assault and facilitates germination. In Bacillus anthracis, the spore is the etiological agent of anthrax, and the functions of the coat likely contribute to virulence. Here, we characterize a B. anthracis spore protein, called Cotbeta, which is encoded only in the genomes of the Bacillus cereus group. We found that Cotbeta is synthesized specifically during sporulation and is assembled onto the spore coat surface. Our analysis of a cotbeta null mutant in the Sterne strain reveals that Cotbeta has a role in determining coat-surface morphology but does not detectably affect germination. In the fully virulent Ames strain, a cotbeta null mutation has no effect on virulence in a murine model of B. anthracis infection.
The Cardiff Study of All Wales and North West of England Twins (CaStANET): A Longitudinal Research Program of Child and Adolescent Development

Abstract The study of twins and their families provides a highly useful tool for disentangling the genetic and environmental origins of traits. The Cardiff Study of All Wales and North West of England Twins (CaStANET) has followed children and adolescents over time into early adulthood, assessing a wide range of aspects of behavior and psychopathology using self-, parent and teacher reports. Four main waves of data collection have taken place to date, which have provided a wealth of information on the contributions of genetic and environmental risk factors to the psychological health of young people. This article first describes the CaStANET register and subsequently presents some of the findings that have emerged from this resource, with a focus on depression and anxiety, chronic fatigue, attention-deficit/hyperactivity disorder, conduct problems and prosocial behavior. We describe in somewhat more detail the 4th wave of data collection, which has recently been completed and has provided us with extensive information on substance use and problem use as well as associated risk factors in the twins and their families, including longitudinal data on conduct problems and the relations between family members. Because of the wealth of data already collected and the opportunity for genetically informative analyses over time, CaStANET provides a valuable resource for understanding the complexities of the psychological development of young people.
Unrecognised ventricular dysfunction in COPD

While both chronic congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD) impose a substantial disease burden and share aetiological and epidemiological associations, they have largely been studied separately. The aim of our study was to assess the prevalence and the prognostic implications of the coexistence of left ventricular dysfunction in COPD patients and airway obstruction in CHF patients. We used a prospective cohort study including stable ≥60-yr-old patients with echocardiographically confirmed CHF (n=201) and stable ≥60-yr-old patients with clinically and spirometry-confirmed COPD (n=218). All CHF patients underwent routine spirometry, and all COPD patients underwent routine echocardiographic assessment and B-type natriuretic peptide (BNP) measurement. Patients were followed for 2 yrs. The prevalence of airway obstruction among CHF patients was 37.3% and the prevalence of ventricular dysfunction among COPD patients was 17%. The presence of ventricular dysfunction in patients with COPD tended to increase the risk of mortality during follow-up (hazard ratio 2.34, 95% CI 0.99–5.54; p=0.053). The presence of airway obstruction in patients with CHF did not influence survival. CHF and COPD frequently coexist, and ventricular dysfunction worsens survival in patients with COPD. Considering the high prevalence and the prognostic implications of ventricular dysfunction, routine assessment with either BNP or echocardiogram should be considered in COPD patients.
Exploration of short and long term memory in adults who do and do not stutter

The purpose of the present study is to look at short-term and long-term memory differences between persons who do and do not stutter. Adults who do and do not stutter listened to lists of 12 phonologically related, 12 semantically related, and 12 neutral words. Both groups will be required to recall these words immediately and after a 20-minute time delay where participants were presented with interference tasks. It was hypothesized that persons who stutter would demonstrate lower recall than adults who do not stutter on the immediate recall of phonological lists but that no such differences would be observed for the semantic or control lists. Further, that after multiple exposures to these word lists the initial immediate recall differences will dissipate. Taken together, these predictions would lend further support to the notion that phonological working memory is initially more taxing for AWS. No significant differences were seen on short-term or long-term accuracy rates between speaker groups for the phonological, semantic, or control list conditions. AWS saw a significantly higher rate of increase on performance from first to last short-term trials on phonological condition than AWNS counterpart. This difference was not seen for semantic or control conditions.