Miracle-dz/UniFAR-FTUs huggingface dataset:
CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for Weight-Loss in a Mediterranean Population

Objective The goals of this research was (1) to analyze the role of emotional eating behavior on weight-loss progression during a 30-week weight-loss program in 1,272 individuals from a large Mediterranean population and (2) to test for interaction between CLOCK 3111 T/C SNP and emotional eating behavior on the effectiveness of the weight-loss program. Design and Methods A total of 1,272 overweight and obese participants (BMI: 31±5 kg/m2), aged 20 to 65 years, attending outpatient weight-loss clinics were recruited for this analysis. Emotional eating behavior was assessed by the Emotional Eating Questionnaire (EEQ), a questionnaire validated for overweight and obese Spanish subjects. Anthropometric measures, dietary intake and weight-loss progression were assessed and analyzed throughout the 30-week program. Multivariate analysis and linear regression models were performed to test for gene-environment interaction. Results Weight-loss progression during the 30-week program differed significantly according to the degree of emotional eating behavior. Participants classified as ‘very emotional eaters’ experienced more irregular (P = 0.007) weight-loss, with a lower rate of weight decline (−0.002 vs. −0.003, P<0.05) in comparison with less emotional eaters. The percentage of weight-loss was also significantly higher in ‘non-emotional eaters’ (P = 0.009). Additionally, we identified a significant gene-environment interaction associated with weight-loss at the CLOCK 3111 T/C locus (P = 0.017). By dichotomizing the emotional eating behavior score, linear regression analysis indicated that minor C allele carriers with a high emotional score (> = 11), lost significantly less weight than those C carriers with a low emotional score (<11) (P = 0.005). Conclusions Emotional eating behavior associates with weight-loss pattern, progression and total weight-loss. Additionally, CLOCK 3111 T/C SNP interacts with emotional eating behavior to modulate total weight loss. These results suggest that the assessment of this locus and emotional eating behavior could improve the development of effective, long-tern weight-management interventions.
Phosphorous Immobility During Formation of the Layered Sulfate Deposits of the Burns Formation at Meridiani Planum

The relatively high abundance of phosphorous (P) in rocks from the Martian crust makes it a potentially useful element for tracking geochemical processes. Owing to the high solubility of common P‐bearing minerals such as apatite at low pH, P is widely thought to be mobile under acid‐sulfate conditions. Accordingly, transport of P by acidic fluids has been invoked to explain enrichments or depletions of this element in some rocks and soils from Mars. The sediments that compose the layered‐sulfate deposits of the Burns formation at Meridiani Planum were originally derived from a basaltic precursor but appear to have been exposed to acidic, sulfate‐rich fluids at several intervals during their history. Yet, assessment of the chemical composition of the bedrocks indicates that they maintain pristine igneous P:Ti ratios and P abundances similar to Martian basalts, indicating that there has been little or no transport of P into or out of the deposits at any stage in their formation. Potential reservoirs for P in the deposits include basaltic glass, secondary Fe‐ or Al‐phosphate minerals, substitution of PO4 for SO4 in alunite‐jarosite group minerals, or surface adsorption. Although Fe‐phosphates were not among the minerals detected by the Mössbauer spectrometer onboard the Opportunity rover at Meridiani, it might be difficult to detect such minerals even if they are present because they are below the detection limit or have signatures similar to other minerals. Overall, the results demonstrate that P can be immobile even in some acid‐sulfate environments on Mars and Earth.
Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells

Interferon gamma (IFN-gamma), a lymphokine that exerts multiple immunoregulatory effects, has been found to be elevated in the plasma, cerebrospinal fluid, and lymph nodes of human immunodeficiency virus (HIV)-infected individuals and has shown variable effects on HIV replication in acutely infected cells. In the present study, we have demonstrated that IFN-gamma is a potent modulator of HIV expression in persistently infected U1 promonocytic cells in which virus production is characterized by a constitutive state of relative latency. Direct stimulation of U1 cells with IFN-gamma (10-1,000 U/ml) activated HIV expression, as measured by reverse transcriptase (RT) activity in the culture supernatant and increased levels of cell-associated viral protein and mRNAs. These effects on virus expression were not accounted for by the induction of endogenous TNF-alpha secretion, as previously described in U1 cells stimulated with phorbol myristate acetate (PMA). At the ultrastructural level, the stimulatory activity of IFN-gamma was correlated with HIV particle production in intracytoplasmic vacuoles along with the differentiation of U1 into macrophage-like cells. Furthermore, costimulation of U1 cells with IFN-gamma and PMA significantly increased the accumulation of vacuole-associated HIV concomitant with decreasing membrane-associated particles and RT activity production, as compared with cells stimulated with PMA alone. No evidence of spontaneous secretion of intracellular vacuole-associated virus was obtained by kinetic analysis of the RT activity released in the supernatants throughout the culture period unless cells were deliberately disrupted. These findings suggest that vacuole-associated virions likely represent a relatively stable intracellular reservoir of HIV, as previously described in primary macrophages infected in vitro or in infected macrophages in the brains of patients with acquired immune deficiency syndrome. The reduced levels of RT activity observed in the culture supernatants of U1 cells stimulated with PMA in the presence of IFN-gamma were not indicative of a suppressive effect of IFN-gamma on PMA-induced expression of HIV proteins and mRNAs, either directly or mediated by the release of IFN-alpha/beta. This study suggests that IFN-gamma may play an important role as an inducer of HIV expression in infected mononuclear phagocytes.
Orphan status, HIV risk behavior, and mental health among adolescents in rural Kenya.

OBJECTIVE To examine orphan status, mental health, social support, and HIV risk among adolescents in rural Kenya. METHODS Randomly selected adolescents aged 10-18 years completed surveys assessing sexual activity, sex-related beliefs and self-efficacy, mental health, social support, caregiver-child communication, time since parental death, and economic resources. Analysis of covariance and regression analyses compared orphans and nonorphans; orphan status was tested as a moderator between well-being and HIV risk. RESULTS Orphans reported poorer mental health, less social support, and fewer material resources. They did not differ from nonorphans on HIV risk indicators. Longer time since parental death was associated with poorer outcomes. In moderator analyses, emotional problems and poorer caregiver-youth communication were more strongly associated with lower sex-related self-efficacy for orphans. CONCLUSIONS Orphans are at higher risk for psychosocial problems. These problems may affect orphans' self-efficacy for safer sex practices more than nonorphans. Decreased HIV risk could be one benefit of psychosocial interventions for orphans.
Detaching from the negative by reappraisal: the role of right superior frontal gyrus (BA9/32)

The ability to reappraise the emotional impact of events is related to long-term mental health. Self-focused reappraisal (REAPPself), i.e., reducing the personal relevance of the negative events, has been previously associated with neural activity in regions near right medial prefrontal cortex, but rarely investigated among brain-damaged individuals. Thus, we aimed to examine the REAPPself ability of brain-damaged patients and healthy controls considering structural atrophies and gray matter intensities, respectively. Twenty patients with well-defined cortex lesions due to an acquired circumscribed tumor or cyst and 23 healthy controls performed a REAPPself task, in which they had to either observe negative stimuli or decrease emotional responding by REAPPself. Next, they rated the impact of negative arousal and valence. REAPPself ability scores were calculated by subtracting the negative picture ratings after applying REAPPself from the ratings of the observing condition. The scores of the patients were included in a voxel-based lesion-symptom mapping (VLSM) analysis to identify deficit related areas (ROI). Then, a ROI group-wise comparison was performed. Additionally, a whole-brain voxel-based-morphometry (VBM) analysis was run, in which healthy participant's REAPPself ability scores were correlated with gray matter intensities. Results showed that (1) regions in the right superior frontal gyrus (SFG), comprising the right dorsolateral prefrontal cortex (BA9) and the right dorsal anterior cingulate cortex (BA32), were associated with patient's impaired down-regulation of arousal, (2) a lesion in the depicted ROI occasioned significant REAPPself impairments, (3) REAPPself ability of controls was linked with increased gray matter intensities in the ROI regions. Our findings show for the first time that the neural integrity and the structural volume of right SFG regions (BA9/32) might be indispensable for REAPPself. Implications for neurofeedback research are discussed.
Detection and interpretation of anomalies in building energy use through inverse modeling

This article presents a study in which three inverse modeling techniques were applied to hourly heating and cooling load data extracted from 35 office buildings in Ottawa, Canada. These modeling techniques were three-parameter change point models, regression trees, and artificial neural networks. The change point models were trained with outdoor temperature data, whereas the other two models were trained with four regressors: outdoor temperature, wind speed, horizontal solar irradiance, and a binary work hours indicator. The correlations among the change point model parameters of individual buildings were analyzed. The sensitivity of heating and cooling load intensities to the four regressors was examined. The models were used to identify several types of energy use anomalies. The anomalies detected by different modeling techniques were generally in agreement. The results indicate that nearly half of the buildings did not have effective after-hours schedules to save energy. In all but three buildings, the cooling change point temperature was lower than the heating change point temperature—indicating a simultaneous heating and cooling problem. Moreover, a few buildings with anomalies potentially related to high air infiltration or overventilation, high thermal conductance, and high solar heat gains during summer were identified.
Seroprevalence and Risk Factors of Chlamydia Infection in Domestic Rabbits (Oryctolagus cuniculus) in China

Chlamydia spp. are obligate intracellular bacteria distributed all over the world, known to cause various forms of diseases in animals and humans. In the present study, a serological survey was conducted to detect the seroprevalence and risk factors associated with rabbit chlamydiosis in northeast China, including Liaoning province, Jilin province, Heilongjiang province, and Inner Mongolia Autonomous Region. Antibodies to Chlamydia were determined by indirect hemagglutination assay (IHA). The overall seroprevalence was estimated at 17.88% in total of 800 blood samples. The Chlamydia seroprevalence varied in domestic rabbits from different factors, and genders of domestic rabbits were considered as major risk factors associated with Chlamydia infection. Our study revealed a widespread and high prevalence of Chlamydia infection in domestic rabbits in northeast China, with higher exposure risk in female domestic rabbits. These findings suggested the potential importance of domestic rabbits in the transmission of zoonotic Chlamydia infection, and thus Chlamydia should be taken into consideration in diagnosing rabbit diseases. To our knowledge, there is no report of Chlamydia infection in domestic rabbits in China and the results extend the host range for Chlamydia, which has important implications for public health and the local economy.
Eigenvalue bounds on the pseudocodeword weight of expander codes

Four different ways of obtaining low-density parity-check codes from expander graphs are considered. For each case, lower bounds on the minimum stopping set size and the minimum pseudocodeword weight of expander (LDPC) codes are derived. These bounds are compared with the known eigenvalue-based lower bounds on the minimum distance of expander codes. Furthermore, Tanner's parity-oriented eigenvalue lower bound on the minimum distance is generalized to yield a new lower bound on the minimum pseudocodeword weight. These bounds are useful in predicting the performance of LDPC codes under graph-based iterative decoding and linear programming decoding.
Synaptic Kainate Receptors in Interplay with INaP Shift the Sparse Firing of Dentate Granule Cells to a Sustained Rhythmic Mode in Temporal Lobe Epilepsy

Dentate granule cells, at the gate of the hippocampus, use coincidence detection of synaptic inputs to code afferent information under a sparse firing regime. In both human patients and animal models of temporal lobe epilepsy, mossy fibers sprout to form an aberrant glutamatergic network between dentate granule cells. These new synapses operate via long-lasting kainate receptor-mediated events, which are not present in the naive condition. Here, we report that in chronic epileptic rat, aberrant kainate receptors in interplay with the persistent sodium current dramatically expand the temporal window for synaptic integration. This introduces a multiplicative gain change in the input–output operation of dentate granule cells. As a result, their sparse firing is switched to an abnormal sustained and rhythmic mode. We conclude that synaptic kainate receptors dramatically alter the fundamental coding properties of dentate granule cells in temporal lobe epilepsy.
Does the age-related positivity effect in autobiographical recall reflect differences in appraisal or memory?

OBJECTIVES Two studies examined the extent to which the age-related positivity effect in autobiographical recall is the result of age differences in appraisal and memory. METHODS In Study 1, older and younger participants reported 1 pleasant and 1 unpleasant event for 5 days. Participants attempted to recall those events a week later. In Study 2, older and younger participants imagined that positive, negative, and neutral hypothetical events had occurred either to themselves or to an acquaintance and were later asked to recall those events. RESULTS In Study 1, younger adults reported a complete set of positive and negative events. Older adults reported a pleasant event each day, but 38% did not report an unpleasant event on at least 1 day. A week later, older and younger adults were equally likely to recall the events they had reported. In Study 2, older adults who imagined events happened to themselves rated events as more positive in valence than younger adults did. Older and younger adults were equally likely to remember pleasant and unpleasant events at the end of the study. DISCUSSION The data suggest that the age-related positivity effect resides in the appraisal rather than the recall of autobiographical events.
Coevolution of T‐cell receptors with MHC and non‐MHC ligands

The structure and amino acid diversity of the T‐cell receptor (TCR), similar in nature to that of Fab portions of antibodies, would suggest that these proteins have a nearly infinite capacity to recognize antigen. Yet all currently defined native T cells expressing an α and β chain in their TCR can only sense antigen when presented in the context of a major histocompatibility complex (MHC) molecule. This MHC molecule can be one of many that exist in vertebrates, presenting small peptide fragments, lipid molecules, or small molecule metabolites. Here we review the pattern of TCR recognition of MHC molecules throughout a broad sampling of species and T‐cell lineages and also touch upon T cells that do not appear to require MHC presentation for their surveillance function. We review the diversity of MHC molecules and information on the corresponding T‐cell lineages identified in divergent species. We also discuss TCRs with structural domains unlike that of conventional TCRs of mouse and human. By presenting this broad view of TCR sequence, structure, domain organization, and function, we seek to explore how this receptor has evolved across time and been selected for alternative antigen‐recognition capabilities in divergent lineages.
Mid-Miocene uplift of the northern Qilian Shan as a result of the northward growth of the northern Tibetan Plateau

The northern Tibetan Plateau, north of the Qaidam Basin and south of the Hexi Corridor (China), consists of a series of WNWto NW-trending elongated mountain ranges. Deciphering the time-space deformation pattern of these ranges is central to understanding the mechanism of plateau formation and to the controversial issue of whether Tibet has undergone progressive northward growth or synchronous growth since the India-Eurasia collision. Here, we report new constraints on the timing of accelerated uplift of the Tuolai Shan, one of the elongated mountain ranges in the northern Tibetan Plateau. New apatite fission-track data from an elevation transect in the Tuolai Shan provide a definitive tie to rapid cooling that began at 17–15 Ma. We attribute this rapid cooling to accelerated exhumation resulting from thrusting in the hanging wall of the Haiyuan fault in response to progressive northward growth of the plateau. Combining these fission-track data and the published geologic, sedimentological, and thermochronologic data from the northern Qilian Shan and Hexi Corridor, we propose a progressively north-northeastward growth model for the northernmost part of Tibet, suggesting that deformation in the inner Qilian Shan occurred synchronously in the middle Miocene, and subsequently, increasingly further north.
PowerChief: Intelligent power allocation for multi-stage applications to improve responsiveness on power constrained CMP

Modern user facing applications consist of multiple processing stages with a number of service instances in each stage. The latency profile of these multi-stage applications is intrinsically variable, making it challenging to provide satisfactory responsiveness. Given a limited power budget, improving the end-to-end latency requires intelligently boosting the bottleneck service across stages using multiple boosting techniques. However, prior work fail to acknowledge the multi-stage nature of user-facing applications and perform poorly in improving responsiveness on power constrained CMP, as they are unable to accurately identify bottleneck service and apply the boosting techniques adaptively. In this paper, we present PowerChief, a runtime framework that 1) provides joint design of service and query to monitor the latency statistics across service stages and accurately identifies the bottleneck service during runtime; 2) adaptively chooses the boosting technique to accelerate the bottleneck service with improved responsiveness; 3) dynamically reallocates the constrained power budget across service stages to accommodate the chosen boosting technique. Evaluated with real world multi-stage applications, PowerChief improves the average latency by 20.3× and 32.4× (99% tail latency by 13.3× and 19.4×) for Sirius and Natural Language Processing applications respectively compared to stage-agnostic power allocation. In addition, for the given QoS target, PowerChief reduces the power consumption of Sirius and Web Search applications by 23% and 33% respectively over prior work.
Is the EQ–5D fit for purpose in mental health?

Summary The EQ–5D is a widely used questionnaire for calculating quality-adjusted life-years (QALYs) for assessing cost-effectiveness in healthcare. It reflects the impact of common mental health conditions such as mild to moderate depression but seems to be more problematic for use in people with psychotic and severe and complex nonpsychotic disorders.
Differences in Soil Fungal Communities between European Beech (Fagus sylvatica L.) Dominated Forests Are Related to Soil and Understory Vegetation

Fungi are important members of soil microbial communities with a crucial role in biogeochemical processes. Although soil fungi are known to be highly diverse, little is known about factors influencing variations in their diversity and community structure among forests dominated by the same tree species but spread over different regions and under different managements. We analyzed the soil fungal diversity and community composition of managed and unmanaged European beech dominated forests located in three German regions, the Schwäbische Alb in Southwestern, the Hainich-Dün in Central and the Schorfheide Chorin in the Northeastern Germany, using internal transcribed spacer (ITS) rDNA pyrotag sequencing. Multiple sequence quality filtering followed by sequence data normalization revealed 1655 fungal operational taxonomic units. Further analysis based on 722 abundant fungal OTUs revealed the phylum Basidiomycota to be dominant (54%) and its community to comprise 71.4% of ectomycorrhizal taxa. Fungal community structure differed significantly (p≤0.001) among the three regions and was characterized by non-random fungal OTUs co-occurrence. Soil parameters, herbaceous understory vegetation, and litter cover affected fungal community structure. However, within each study region we found no difference in fungal community structure between management types. Our results also showed region specific significant correlation patterns between the dominant ectomycorrhizal fungal genera. This suggests that soil fungal communities are region-specific but nevertheless composed of functionally diverse and complementary taxa.