Miracle-dz/UniFAR-FTUs huggingface dataset:
Aberrant Methylation of CDH13 is a Potential Biomarker for Predicting the Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer

Background CDH13 is a novel tumor suppressor gene often inactivated by aberrant promoter methylation in human cancers. Previous studies have shown that CDH13 methylation correlated with advanced disease and poor prognosis in non-muscle invasive bladder cancer (NMIBC). The aim of the current study was to investigate the correlations between CDH13 methylation and disease recurrence as well as progression of NMIBC. Material/Methods The methylation status of CDH13 in 178 NMIBC samples and 38 normal bladder epithelial tissues was examined by methylation-specific PCR (MSP), and then correlated with clinicopathological features. Results We found that CDH13 methylation occurs frequently in NMIBC, and significantly correlates with high grade, advanced stage, larger tumor size, and tumor recurrence and progression. Moreover, patients with methylated CDH13 exhibited significantly shorter recurrence-free survival (P<0.0001) and progression-free survival (P=0.0060) than patients with unmethylated CDH13. In addition, a multivariate Cox proportional hazard model analysis suggests that CDH13 methylation is an independent predictor for the recurrence (P=0.0043) and progression (P=0.0016) of NMIBC after initial transurethral resection. Conclusions Our findings demonstrate that CDH13 methylation is a frequent event in NMIBC, and is associated with unfavorable tumor features. It should be used as an independent predictor for the recurrence and progression of NMIBC, and may be useful for the design of individualized therapeutic modalities.
Mechanisms of Coordination in Distributed Neural Circuits: Encoding Coordinating Information

We describe synaptic connections through which information essential for encoding efference copies reaches two coordinating neurons in each of the microcircuits that controls limbs on abdominal segments of the crayfish, Pacifastacus leniusculus. In each microcircuit, these coordinating neurons fire bursts of spikes simultaneously with motor neurons. These bursts encode timing, duration, and strength of each motor burst. Using paired microelectrode recordings, we demonstrate that one class of nonspiking neurons in each microcircuit's pattern-generating kernel—IPS—directly inhibits the ASCE coordinating neuron that copies each burst in power-stroke (PS) motor neurons. This inhibitory synapse parallels IPS's inhibition of the same PS motor neurons. Using a disynaptic pathway to control its membrane potential, we demonstrate that a second type of nonspiking interneuron in the pattern-generating kernel—IRSh—inhibits the DSC coordinating neuron that copies each burst in return-stroke (RS) motor neurons. This inhibitory synapse parallels IRS's inhibition of the microcircuit's RS motor neurons. Experimental changes in the membrane potential of one IPS or one IRSh neuron simultaneously changed the strengths of motor bursts, durations, numbers of spikes, and spike frequency in the simultaneous ASCE and DSC bursts. ASCE and DSC coordinating neurons link the segmentally distributed microcircuits into a coordinated system that oscillates with the same period and with stable phase differences. The inhibitory synapses from different pattern-generating neurons that parallel their inhibition of different sets of motor neurons enable ASCE and DSC to encode details of each oscillation that are necessary for stable, adaptive synchronization of the system.
Quality of life and severity of skin changes in the dynamics of psoriasis

Introduction Psoriasis is a chronic skin disease with periods of recurrence and remission. The skin changes which are typical of this disease can have a considerable effect on the patient's psychological state, self-esteem and body image. It can also affect the patient's functioning in all areas of life and quality of life. Aim The present study characterized the patient needs to improve the quality of life in specified areas in patients depending on the severity of psoriatic changes. Material and methods The study was conducted in two stages on 100 patients aged from 18 to 66. A dermatological examination was conducted in stage one. Patients’ dermatological condition was assessed with the Psoriasis Area and Severity Index (PASI). Clinical and socio-economic information was collected in stage two using a questionnaire, a medical interview and a standardized questionnaire measuring quality of life, the WHOQOL-BREF. Results The following factors had the greatest effect on the general quality of life and quality of health ratings in the studied sample: severity of psoriatic changes, duration of the most recent recurrence and sex. Severity of psoriatic changes had a negative effect on the patient's somatic, psychological, environmental and social functioning. Duration of the most recent recurrence had a negative effect on social functioning. Practical implications of this study allow dermatologists to determine the appropriate therapeutic intervention which improves the quality of life of these patients on the one hand, and will increase patient's involvement in the process of treatment on the other hand. Conclusions Quality of life is more impaired by more severe chronic skin disease.
A Framework for Supporting Students with Learning Disabilities in Spanish Courses: Connecting Learning Characteristics and Instructional Methods

Students with learning disabilities are characterized by highly individualized dysfunction of the central nervous system. Current research has suggested that the learning difficulties experienced may be attributable to processing difficulties in working memory, attention, information retrieval, and phonological processing. In educational environments, students with learning disabilities often struggle to meet the demands of the general curriculum and require support or intervention to reveal their potential. Because the demands of learning an unfamiliar language can expose weaknesses and heighten anxiety, individuals with learning disabilities have often avoided or been discouraged from foreign language study. However, research conducted on the use of multi-sensory approaches has indicated that such instruction can help students with learning disabilities to succeed in learning Spanish. A discussion of the relationship between neurological research and multi-sensory teaching provides implications for persons with learning disabilities experiencing meaningful inclusion in Spanish courses. Application of research and associated theory to practice is expressed in the form of examples of general accommodations, existing resources, and learning strategies which provide a framework for students with LD to have positive experiences in Spanish.
Computing Popov Form of Ore Polynomial Matrices

We show that the computation of the Popov form of Ore polynomial matrices can be formulated as a problem of computing the left nullspace of such matrices. While this technique is already known for polynomial matrices, the extension to Ore polynomial matrices is not immediate because multiplication of the matrix entries is not commutative. A number of results for polynomial matrices are extended to Ore polynomial matrices in this paper. This in turn allows nullspace algorithms to be used in Popov form computations when the input matrix has full row rank. In particular, recent fraction-free and modular algorithms for nullspace computation can be used in exact arithmetic setting where coefficient growth is a concern. In the case when the input matrix does not have full row rank, we show that if a degree bound on the minimal unimodular multiplier is known, the Popov form computation can also be reduced to left nullspace computation.
On the short string limit of the folded spinning string in AdS5 x S5

In this paper we generalize the results of arXiv:0806.4758 to non-zero value J of angular momentum in S^5. We compute the 1-loop correction to the energy of the folded spinning string in AdS_5 x S^5 in the particular limit of slow short string approximation. In this limit the string is moving in a near-flat central region of AdS_5 slowly rotating in both AdS_5 and S^5. The one-loop correction should represent the first subleading correction to strong coupling expansion of the anomalous dimension of short gauge theory operators of the form Tr D^S Z^J in the SL(2) sector.
RPL protocol adapted for healthcare and medical applications

This paper focuses on wireless sensor networks (WSNs) for healthcare and medical applications which aim to look after patients by monitoring vital signs, diagnostics and drug administrations. WSNs in such applications are usually composed of different types of small-size battery powered sensors. In fact, wearable sensors are used to collect information about the signs of a person that needs a medical care. Static sensors, deployed inside the hospital or the home building, are used to collect information about indoor environment. The collected data is then transmitted towards the sink. Since some patients can move, WSN topology is hybrid and composed of mobile and static nodes. Routing Protocol for Low Power and Lossy Networks (RPL), an IPv6 distance vector routing protocol designed for static wireless sensor network, can be adapted to our need. So in this paper, we propose to modify RPL in order to fit with an hybrid topology. The performance of the modified protocol is evaluated and compared with the existing RPL protocol. The results show that our protocol optimization for healthcare application offers better performance.
Dynamics of Inflation, Output Growth and Their Uncertainty in the UK: An Empirical Analysis

The aim of this paper is to analyse the dynamics relationships between inflation, output growth, and real and nominal uncertainty using the VARFIMA-BEKK MGARCH model of inflation and output growth and quarterly data for the UK covering the 1957:Q2–2006:Q4 period. The analysis is also done for the three sub-periods determined by considering the structural changes such as the Great Moderation in the series of the UK. Two findings are obtained. First, the evidence obtained from the full period supports a number of important conclusions, one of which is mixed evidence regarding the effect of inflation on inflation uncertainty, another one being strong evidence regarding the positive effect of inflation uncertainty on inflation and output growth. Taking this into account, it is possible to put forward that an essential determinant of economic growth is uncertainty about the inflation rate. The last finding for this period is that output growth uncertainty is a positive determinant of the inflation and output growth rate. Second, the evidence found from the sub-periods is that there are no linkages between inflation, output growth and their volatility.
Economic Cycles, Asymmetric Crises and Tourism Competitiveness: Emerging Versus Mature Destinations

This paper considers the influence of business cycles and economic crises on tourism destinations competitiveness. This competitiveness is measured by its share in world tourism. Analysing a period of forty years, the differential permanent or temporary effects that economic crises has on competitiveness of mature and emerging destinations are observed. Furthermore, it identifies the economic transmission mechanisms operating within this context, analysing them using the framework of the most relevant explanatory models of tourism destination competitiveness. The preliminary results obtained suggest that the effects of these shocks on competitiveness are not neutral. In mature destinations the negative effects are more persistent in highly intensive crises. In emerging destinations with a growing natural trend on tourism demand, the effects of the economic crises are softer and limited, reinforcing the process of convergence between destinations. This effect works through two basic transmission mechanisms: the reduction of internal and external tourism demand and the decrease on investment.
Post-Unification Wage Growth in East Germany

Following monetary union with West Germany in 1990, the real wage of East German workers rose 83. I use the German Socio-Economic Panel data to investigate the determinants of wage growth, and assess whether they are consistent with efficient restructuring. Although job-changing rates were initially high, the share of wage growth that accrued to movers was little higher than in the west, suggesting that the incentives to move were too low. For 1990 to 1991, the biggest gainers were low-wage workers generally, and women and the less-educated specifically. For 1991 to 1996, the biggest gainers were women and the better-educated.
Whole Genome Expression Profiles of Yeast RNA Polymerase II Core Subunit, Rpb4, in Stress and Nonstress Conditions* 210

Organisms respond to environmental stress by adopting changes in gene expression at the transcriptional level. Rpb4, a nonessential subunit of the core RNA polymerase II has been proposed to play a role in non-stress-specific transcription and in the regulation of stress response in yeast. We find that in addition to the temperature sensitivity of the null mutant of Rpb4, diploid null mutants are also compromised in sporulation and show morphological changes associated with nitrogen starvation. Using whole genome expression analysis, we report here the effects of Rpb4 on expression of genes during normal growth and following heat shock and nutritional starvation. Our analysis shows that Rpb4 affects expression of a small yet significant fraction of the genome in both stress and normal conditions. We found that genes involved in galactose metabolism were dependent on the presence of Rpb4 irrespective of the environmental condition. Rpb4 was also found to affect the expression of several other genes specifically in conditions of nutritional starvation. The general defect in the absence of Rpb4 is in the expression of metabolic genes, especially those involved in carbon metabolism and energy generation. We report that various stresses are affected byRPB4 and that on overexpression the stress-specific activators can partially rescue the corresponding defects.
In the Shadow of the Welfare State: The Role of Payday Lending in Poverty Survival in Australia

Abstract A defining characteristic of contemporary welfare governance in many western countries has been a reduced role for governments in direct provision of welfare, including housing, education, health and income support. One of the unintended consequences of devolutionary trends in social welfare is the development of a ‘shadow welfare state’ (Fairbanks, 2009; Gottschalk, 2000), which is a term used to describe the complex partnerships between state-based social protection, voluntarism and marketised forms of welfare. Coupled with this development, conditional workfare schemes in countries such as the United States, Canada, the UK and Australia are pushing more people into informal and semi-formal means of poverty survival (Karger, 2005). These transformations are actively reshaping welfare subjectivities and the role of the state in urban governance. Like other countries such as the US, Canada and the UK, the fringe lending sector in Australia has experienced considerable growth over the last decade. Large numbers of people on low incomes in Australia are turning to non-mainstream financial services, such as payday lenders, for the provision of credit to make ends meet. In this paper, we argue that the use of fringe lenders by people on low incomes reveals important theoretical and practical insights into the relationship between the mixed economy of welfare and the mixed economy of credit in poverty survival.
Cognitive processing load during listening is reduced more by decreasing voice similarity than by increasing spatial separation between target and masker speech

We investigated changes in speech recognition and cognitive processing load due to the masking release attributable to decreasing similarity between target and masker speech. This was achieved by using masker voices with either the same (female) gender as the target speech or different gender (male) and/or by spatially separating the target and masker speech using HRTFs. We assessed the relation between the signal-to-noise ratio required for 50% sentence intelligibility, the pupil response and cognitive abilities. We hypothesized that the pupil response, a measure of cognitive processing load, would be larger for co-located maskers and for same-gender compared to different-gender maskers. We further expected that better cognitive abilities would be associated with better speech perception and larger pupil responses as the allocation of larger capacity may result in more intense mental processing. In line with previous studies, the performance benefit from different-gender compared to same-gender maskers was larger for co-located masker signals. The performance benefit of spatially-separated maskers was larger for same-gender maskers. The pupil response was larger for same-gender than for different-gender maskers, but was not reduced by spatial separation. We observed associations between better perception performance and better working memory, better information updating, and better executive abilities when applying no corrections for multiple comparisons. The pupil response was not associated with cognitive abilities. Thus, although both gender and location differences between target and masker facilitate speech perception, only gender differences lower cognitive processing load. Presenting a more dissimilar masker may facilitate target-masker separation at a later (cognitive) processing stage than increasing the spatial separation between the target and masker. The pupil response provides information about speech perception that complements intelligibility data.
Noise Momentum Around the World

We argue that arbitrageurs will strategically limit their initial investment in an arbitrage opportunity in anticipation of further mispricing caused by the deepening of noise traders' misperceptions. Such ‘noise momentum’ is an important determinant of the overall arbitrage process. We design an empirical strategy to capture noise momentum in a two-period generalized error correction model. Applying it to a wide range of international spot-futures market pairs, we document pervasive evidence of noise momentum around the world.
Nitrogen attenuation of terrestrial carbon cycle response to global environmental factors

Nitrogen cycle dynamics have the capacity to attenuate the magnitude of global terrestrial carbon sinks and sources driven by CO2 fertilization and changes in climate. In this study, two versions of the terrestrial carbon and nitrogen cycle components of the Integrated Science Assessment Model (ISAM) are used to evaluate how variation in nitrogen availability influences terrestrial carbon sinks and sources in response to changes over the 20th century in global environmental factors including atmospheric CO2 concentration, nitrogen inputs, temperature, precipitation and land use. The two versions of ISAM vary in their treatment of nitrogen availability: ISAM‐NC has a terrestrial carbon cycle model coupled to a fully dynamic nitrogen cycle while ISAM‐C has an identical carbon cycle model but nitrogen availability is always in sufficient supply. Overall, the two versions of the model estimate approximately the same amount of global mean carbon uptake over the 20th century. However, comparisons of results of ISAM‐NC relative to ISAM‐C reveal that nitrogen dynamics: (1) reduced the 1990s carbon sink associated with increasing atmospheric CO2 by 0.53 PgC yr−1 (1 Pg = 1015g), (2) reduced the 1990s carbon source associated with changes in temperature and precipitation of 0.34 PgC yr−1 in the 1990s, (3) an enhanced sink associated with nitrogen inputs by 0.26 PgC yr−1, and (4) enhanced the 1990s carbon source associated with changes in land use by 0.08 PgC yr−1 in the 1990s. These effects of nitrogen limitation influenced the spatial distribution of the estimated exchange of CO2 with greater sink activity in high latitudes associated with climate effects and a smaller sink of CO2 in the southeastern United States caused by N limitation associated with both CO2 fertilization and forest regrowth. These results indicate that the dynamics of nitrogen availability are important to consider in assessing the spatial distribution and temporal dynamics of terrestrial carbon sources and sinks.
Allopregnanolone preferentially induces energy‐rich food intake in male Wistar rats

Obesity is an increasing problem and identification of the driving forces for overeating of energy‐rich food is important. Previous studies show that the stress and sex steroid allopregnanolone has a hyperphagic effect on both bland food and palatable food. If allopregnanolone induces a preference for more palatable or for more energy‐rich food is not known. The aim of this study was to elucidate the influence of allopregnanolone on food preference. Male Wistar rats were subjected to two different food preference tests: a choice between standard chow and cookies (which have a higher energy content and also are more palatable than chow), and a choice between a low caloric sucrose solution and standard chow (which has a higher energy content and is less palatable than sucrose). Food intake was measured for 1 h after acute subcutaneous injections of allopregnanolone. In the choice between cookies and chow allopregnanolone significantly increased only the intake of cookies. When the standard chow was the item present with the highest caloric load, the chow intake was increased and allopregnanolone had no effect on intake of the 10% sucrose solution. The increased energy intakes induced by the high allopregnanolone dose compared to vehicle were very similar in the two tests, 120% increase for cookies and 150% increase for chow. It appears that in allopregnanolone‐induced hyperphagia, rats choose the food with the highest energy content regardless of its palatability.
Internalizing Knowledge and Changing Attitudes to Female Genital Cutting/Mutilation

The process of paradigmatic attitudinal change has been analyzed by the use of multimethods and multileveled internalization theories. Forty-six informants (a network of activists and a group of Gambian women) have described their change of attitude to female genital cutting. This study shows that internalizing a packet of information as adults, that contradicts an old schema of knowledge internalized as children, can be experienced as epistemologically very painful. Activists in Norway who have changed their attitude to FGC have got information from different educational institutions, from seminars and conferences, from work as interpreters in hospitals, and from discussions among families and friends. Information can be received, listened to and subsequently discarded. In order to design FGC-abandonment campaigns, the importance of the internalization process in order for the individual to make an attitudinal change must be understood.
A General Formula for Valuing Defaultable Securities

Previous research has shown that under a suitable no-jump condition, the price of a defaultable security is equal to its risk-neutral expected discounted cash flows if a modified discount rate is introduced to account for the possibility of default. Below, we generalize this result by demonstrating that one can always value defaultable claims using expected risk-adjusted discounting provided that the expectation is taken under a slightly modified probability measure. This new probability measure puts zero probability on paths where default occurs prior to the maturity, and is thus only absolutely continuous with respect to the risk-neutral probability measure. After establishing the general result and discussing its relation with the existing literature, we investigate several examples for which the no-jump condition fails. Each example illustrates the power of our general formula by providing simple analytic solutions for the prices of defaultable securities.