Miracle-dz/UniFAR-FTUs huggingface dataset:
Klebsiella meningitis in Taiwan: an overview

Klebsiella infection has been considered to be an uncommon cause of meningitis. To determine its incidence and clinical features, we reviewed the microbiologic records of cerebrospinal fluid (CSF) and blood cultures and the medical records of patients with bacterial meningitis admitted between 1981 and 1995. Klebsiella meningitis was diagnosed in 79 patients with 83 episodes. All patients had klebsiella isolated from CSF and/or blood and typical symptoms and signs of acute bacterial meningitis. Of these, 74 were over 16 years of age and 2 of the 5 children were infants. There was an increased prevalence rate of klebsiella meningitis after 1986. Of the 83 episodes, only 9 occurred between 1981 and 1986, accounting for 7·8% of 115 cases with CSF and/or blood culture-proven acute bacterial meningitis, whereas in 1987–95, there were 74 episodes accounting for 17·7% of 419 bacteriologically proven cases. K. pneumoniae accounted for 69 episodes, K. oxytoca, 11 episodes and K. ozaenae, 3 episodes. Male gender, diabetes mellitus and liver cirrhosis were commonly associated with K. pneumoniae meningitis. Neurosurgical procedures were frequently associated with K. oxytoca meningitis. All three patients with K. ozaenae meningitis had a primary disease of the nasopharyngeal pathway. The mortality rate due to K. pneumoniae was 48·5%, K. oxytoca, 10% and K. ozaenae, 0%. In patients with K. pneumoniae meningitis, poor prognostic factors included age over 60 years, diabetes mellitus, bacteremia and severe neurological deficits on the first day of treatment.
The physics of anomalous (‘rogue’) ocean waves

There is much speculation that the largest and steepest waves may need to be modelled with different physics to the majority of the waves on the open ocean. This review examines the various physical mechanisms which may play an important role in the dynamics of extreme waves. We examine the evidence for these mechanisms in numerical and physical wavetanks, and look at the evidence that such mechanisms might also exist in the real ocean.
Resection of Colorectal Liver Metastases with Extrahepatic Disease

Extrahepatic disease in combination with colorectal liver metastases has long been considered an absolute contraindication for surgery. However, in many reported series, long-term survival is achieved in selected patients with concomitant extrahepatic disease as long as the resection of all metastatic sites is complete. Owing to these results, an increasing number of patients with advanced metastatic colorectal disease are now being referred for surgery. For patients with concomitant liver and lung metastases, sequential resection of both disease sites has proven to be safe, offering a 5-year survival rate of more than 30%. On the contrary, hepatectomy combined with resection of regional lymph node metastases can only provide long-term survival in case of pedicular lymph node involvement. Furthermore, control of the disease by preoperative chemotherapy appears to be crucial. For peritoneal carcinomatosis, aggressive treatment combining cytoreductive surgery and intraperitoneal chemotherapy can offer a chance of prolonged long-term survival to selected patients with limited peritoneal extension. In conclusion, resection of both intra- and extrahepatic colorectal metastases should be considered if resection of all metastatic sites can be complete and the disease is controlled by chemotherapy. Long-term survival in these patients with advanced disease could be achieved if they are managed by experienced multidisciplinary teams.
Epigenetic Analyses and the Distribution of Repetitive DNA and Resistance Genes Reveal the Complexity of Common Bean (Phaseolus vulgaris L., Fabaceae) Heterochromatin

The common bean (Phaseolus vulgaris L.) is the main representative of its genus and one of most important sources of proteins in African and Latin American countries. Although it is a species with a small genome, its pericentromeric and subtelomeric heterochromatin fractions are interspersed with single-copy sequences and active genes, suggesting a less compartmentalized genome organization. The present study characterized its chromatin fractions, associating the distribution of repetitive sequences and resistance genes with histone and DNA epigenetic modifications with and without biotic stress. Immunostaining with H3K4me3 and H4K5ac were generally associated with euchromatic regions, whereas H3K9me2, H3K27me1, and 5mC preferentially labeled the pericentromeric heterochromatin. The 45S rDNA and centromeric DNA sequences were hypomethylated as were most of the terminal heterochromatic blocks. The largest of them, which is associated with resistance genes, was also hypomethylated after the plants were infected with virulent and avirulent strains of the fungus Colletotrichum lindemuthianum, suggesting no correlation with control of resistance gene expression. The results highlighted the differences between subtelomeric and pericentromeric heterochromatin as well as variation within the pericentromeric heterochromatin.
Credit Card Use After the Final Mortgage Payment: Does the Magnitude of Income Shocks Matter?

We test the hypothesis that consumption smoothing occurs after large, but not small, expected future income shocks. Even though this hypothesis has often been discussed, formal evidence in support of it is rare. We use individual level, monthly, bank account data to examine how expected income shocks from final mortgage payments impact credit card consumption, and the repayment of credit card debt. Our data allows us to identify the exact magnitude and date of final mortgage payments, and also to exploit the random timing of these expected income shocks across individuals. Our results are consistent with the magnitude hypothesis. JEL Classification: E42, G21
Evaluation of Automatic Building Detection Approaches Combining High Resolution Images and LiDAR Data

In this paper, two main approaches for automatic building detection and localization using high spatial resolution imagery and LiDAR data are compared and evaluated: thresholding-based and object-based classification. The thresholding-based approach is founded on the establishment of two threshold values: one refers to the minimum height to be considered as building, defined using the LiDAR data, and the other refers to the presence of vegetation, which is defined according to the spectral response. The other approach follows the standard scheme of object-based image classification: segmentation, feature extraction and selection, and classification, here performed using decision trees. In addition, the effect of the inclusion in the building detection process of contextual relations with the shadows is evaluated. Quality assessment is performed at two different levels: area and object. Area-level evaluates the building delineation performance, whereas object-level assesses the accuracy in the spatial location of individual buildings. The results obtained show a high efficiency of the evaluated methods for building detection techniques, in particular the thresholding-based approach, when the parameters are properly adjusted and adapted to the type of urban landscape considered.
Preferences for Prenatal Tests for Cystic Fibrosis: A Discrete Choice Experiment to Compare the Views of Adult Patients, Carriers of Cystic Fibrosis and Health Professionals

As new technologies enable the development of non-invasive prenatal diagnosis (NIPD) for cystic fibrosis (CF), research examining stakeholder views is essential for the preparation of implementation strategies. Here, we compare the views of potential service users with those of health professionals who provide counselling for prenatal tests. A questionnaire incorporating a discrete choice experiment examined preferences for key attributes of NIPD and explored views on NIPD for CF. Adult patients (n = 92) and carriers of CF (n = 50) were recruited from one children’s and one adult NHS specialist CF centre. Health professionals (n = 70) were recruited via an e-mail invitation to relevant professional bodies. The key attribute affecting service user testing preferences was no miscarriage risk, while for health professionals, accuracy and early testing were important. The uptake of NIPD by service users was predicted to be high and includes couples that would currently decline invasive testing. Many service users (47%) and health professionals (55.2%) thought the availability of NIPD for CF would increase the pressure to undergo prenatal testing. Most service users (68.5%) thought NIPD for CF should be offered to all pregnant women, whereas more health professionals (68.2%) thought NIPD should be reserved for known carrier couples. The implications for clinical practice are discussed.
Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5

To evaluate the role that cytochrome (CYP) 3A5 plays in hepatic drug metabolism, the substrate selectivity and inhibitory potential of over 60 compounds towards CYP3A4 and CYP3A5 were assessed using Escherichia coli recombinant cell lines. CYP3A4-mediated metabolism predominated for many of the compounds studied. However, a number of drugs gave similar CLint estimates using CYP3A5 compared with CYP3A4 including midazolam (CLint = 3.4 versus 3.3 µl min–1 pmol–1). Significant CYP3A5-mediated metabolism was also observed for several drugs including mifepristone (CLint = 10.3 versus 2.4 µl min–1 pmol–1), and ritonavir (CLint = 0.76 versus 0.47 µl min–1 pmol–1). The majority of compounds studied showed a greater inhibitory potential (IC50) towards CYP3A4 compared with CYP3A5 (eightfold lower on average). A greater degree of time-dependent inhibition was also observed with CYP3A4 compared with CYP3A5. The range of compounds investigated in the present study extends significantly previous work and suggests that CYP3A5 may have a significant role in drug metabolism particularly in populations expressing high levels of CYP3A5 and/or on co-medications known to inhibit CYP3A4.
Cohesion Metrics for Predicting Maintainability of Service-Oriented Software

Although service-oriented computing (SOC) is a promising paradigm for developing enterprise software systems, existing research mostly assumes the existence of black box services with little attention given to the structural characteristics of the implementing software, potentially resulting in poor system maintainability. Whilst there has been some preliminary work examining coupling in a service-oriented context, there has to date been no such work on the structural property of cohesion. Consequently, this paper extends existing notions of cohesion in OO and procedural design in order to account for the unique characteristics of SOC, allowing the derivation of assumptions linking cohesion to the maintainability of service-oriented software. From these assumptions, a set of metrics are derived to quantify the degree of cohesion of service oriented design constructs. Such design level metrics are valuable because they allow the prediction of maintainability early in the SDLC.
Theoretical framework to study exercise motivation for breast cancer risk reduction.

PURPOSE/OBJECTIVES To identify an appropriate theoretical framework to study exercise motivation for breast cancer risk reduction among high-risk women. DATA SOURCES An extensive review of the literature was conducted to gather relevant information pertaining to the Health Promotion Model, self-determination theory, social cognitive theory, Health Belief Model, Transtheoretical Model, theory of planned behavior, and protection motivation theory. DATA SYNTHESIS An iterative approach was used to summarize the literature related to exercise motivation within each theoretical framework. CONCLUSIONS Protection motivation theory could be used to examine the effects of perceived risk and self-efficacy in motivating women to exercise to facilitate health-related behavioral change. IMPLICATIONS FOR NURSING Evidence-based research within a chosen theoretical model can aid practitioners when making practical recommendations to reduce breast cancer risk.
GEOGRAPHIC VARIATION WITHIN AN ISLAND: UNIVARIATE AND MULTIVARIATE CONTOURING OF SCALATION, SIZE, AND SHAPE OF THE LIZARD GALLOTIA GALLOTI

Microgeographic variation of the vegetarian lizard Gallotia galloti within the island of Tenerife is described using univariate analysis, correlation, multiple group principal component analysis, canonical analysis, transects, and contours. The size varies locally in a mosaic pattern while head shape shows a WNW–ESE cline in the south. The scalation (scale and femoral pore counts) has two facets to its geographic variation, both of which are incongruent with the primary variation in the size and shape. The scalation shows categorical variation (stepped cline) between northern and southern populations and also a strong clinal relationship with altitude. The possible causes of this variation are considered and adaptation to current ecological conditions appears to be implicated for at least the altitudinal variation, although the pertinent factors are not obvious. It is apparent that vertebrate populations distributed across small islands do not necessarily offer the advantage of a discrete homogeneous unit for evolutionary studies but can offer the opportunity for studying microgeographic variation.
A Guide to Fully Homomorphic Encryption

Fully homomorphic encryption (FHE) has been dubbed the holy grail of cryptography, an elusive goal which could solve the IT world’s problems of security and trust. Research in the area exploded after 2009 when Craig Gentry showed that FHE can be realised in principle. Since that time considerable progress has been made in finding more practical and more efficient solutions. Whilst research quickly developed, terminology and concepts became diverse and confusing so that today it can be difficult to understand what the achievements of different works actually are. The purpose of this paper is to address three fundamental questions: What is FHE? What can FHE be used for? What is the state of FHE today? As well as surveying the field, we clarify different terminology in use and prove connections between different FHE notions.
Online vs. In-Store Shopping: How Problem Solving Strategies of Decision Support Systems influence Confidence in Purchase Decisions

Several studies have investigated the relevance of Decision Support Systems (DSS) on purchase behaviour. Even though these studies show several aspects of the utility of DSS, they are limited to online purchase situations, the use of one DSS strategy and one DSS technology. In this paper, we therefore develop a theoretical model that measures the impact of DSS strategies relative to a given purchase problem and an adequate use of DSS technology on consumers' perceived confidence in purchase decisions for both online and in-store purchase situations. In addition, three mediating decision process variables are considered: perceived DSS personalization, perceived relevance of recommendations, and cognitive trust in DSS competence. As a result, the model not only allows evaluating different kinds of purchase-directed DSS but let researchers also draw conclusions on the appropriate use of technology and decision strategies of one individual DSS, which would in turn have practical implications for the design of DSS-enabled future shopping environments
Cardiac Safety of (Neo)Adjuvant Trastuzumab in the Community Setting: A Single-Center Experience

Background: Trastuzumab improves the survival of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). The incidence and long-term impact of trastuzumab-related cardiotoxicity in the community setting is of great clinical importance. Material and Methods: Patients with HER2-positive BC treated with (neo)adjuvant trastuzumab were retrospectively evaluated. Cardiotoxicity was defined as cardiac death or absolute decrease in left ventricular ejection fraction of at least 10% to a value less than 50%, or symptomatic heart failure. Results: We evaluated 237 patients: median age 53 years (range 27-83 years). 40.5% of these patients had received neoadjuvant and 59.5% adjuvant chemotherapy. The majority (83.9%) were treated with an anthracycline-based regimen. Median exposure to trastuzumab was 8 months (range 2-12 months). Cardiotoxicity was diagnosed in 20.2%, but symptoms only occurred in 3.8%. 41.6% recovered cardiac function. None of the risk factors were associated with cardiotoxicity. Conclusion: The incidence of trastuzumab-related cardiotoxicity found in this study was slightly higher than those reported in randomized clinical trials. Nevertheless, most patients were asymptomatic. We describe the cardiac outcomes of a non-selected population, which possibly reflects those found in the ‘real world'. The risks versus benefits of trastuzumab use remain in favor of treatment, but cardiotoxicity should be monitored.
PRAYER AND RELATIONSHIP WITH GOD II: REPLICATION AND EXTENSION OF THE RELATIONAL PRAYER MODEL

Using the explanatory framework of the Relational Prayer Model, and samples of 77 young adults (aged 18-34) and 54 middle-aged individuals (aged 35-65) that identified themselves as "Christian, " correlational and regression analyses indicated that chronological age was positively related to frequency of engaging in prayers of adoration, confession, thanksgiving, supplication, and contemplation (r's=.14-.25). Age was also positively associated with the mystical experience of the holy/sacred during prayer, positive affect during prayer, and perceptions of intimacy with God (r's=.18, .17, .29). The best predictor of intimacy with Godfor young adults was the prayer of thanksgiving while the prayer of adoration was the best predictor for middle-aged adults. Path analyses indicated that age had more of an indirect than a direct effect on relational intimacy with God while frequency of prayer and affect during prayer had direct effects on relational intimacy with God. Several suggestions for future research were offered.
Expected improvement is equivalent to OCBA

This paper summarizes new theoretical results on the asymptotic sampling rates of expected improvement (EI) methods in fully sequential ranking and selection (R&S). These methods have been widely observed to perform well in practice, and often have asymptotic consistency properties, but rate results are generally difficult to obtain when observations are subject to stochastic noise. We find that, in one general R&S problem, variants of EI produce simulation allocations that are virtually identical to the rate-optimal allocations calculated by the optimal computing budget allocation (OCBA) methodology. This result provides new insight into the good empirical performance of EI under normality assumptions.
Cross-Layer Verification of Type Flaw Attacks on Security Protocols

Security protocols are often specified at the application layer; however, application layer specifications give little detail regarding message data structures at the presentation layer upon which some implementation-dependent attacks rely. In this paper we present an approach to verifying security protocols in which both the application and presentation layers are modelled. Using the Group Domain of Interpretation protocol as an example, our application layer specification of the protocol is used as input to the AVISPA model checking tool for analysis. Two type flaw attacks are found via model checking which are then verified against the corresponding presentation layer specification, thus identifying the minimal requirements to prevent the attacks.
Lexical Processing of Ambiguous Words: Dominance or Associative Strength?

Four experiments examined the role of meaning frequency (dominance) and associative strength (measured by associative norms) in the processing of ambiguous words in isolation. Participants made lexical decisions to targets words that were associates of the more frequent (dominant) or less frequent (subordinate) meaning of a homograph prime. The first two experiments investigated the role of associative strength at long SOAs (Stimulus Onset Asynchrony) (750 ms.), showing that meaning is facilitated by the targets' associative strength and not by their dominance. The last two experiments traced the role associative strength at short SOAs (250 ms), showing that the manipulation of the associative strength has no effect in the semantic priming. The conclusions are: on the one hand, semantic priming for homographs is due to associative strength manipulations at long SOAs. On the other hand, the manipulation of the associative strength has no effect when automatic processes (short SOAs) are engaged for homographs. A través de cuatro experimentos, se examinó el papel de la frecuencia del significado (dominancia) y de la fuerza asociativa (medida mediante normas asociativas) en el procesamiento de palabras ambiguas aisladas. Los participantes tomaron decisiones léxicas acerca de palabras meta que eran las asociadas del significado más frecuente (dominante) o menos frecuente (subordinado) de un homógrafo primo. Los primeros dos experimentos investigaron el papel de la fuerza asociativa en las SOAs (asincronía del comienzo del estímulo) largas (750 ms), demostrando que el significado se ve facilitado por la fuerza asociativa de la meta y no por su dominancia. Los segundos experimentos trazaron el papel de la fuerza asociativa en las SOAs cortas (250 ms), demostrando que la manipulación de la fuerza asociativa no influye en la ceba semántica. Se concluye que: (a) la ceba semántica para homográficos se debe a las manipulaciones de la fuerza asociativa en las SOAs largas y (b) la manipulación de la fuerza asociativa no tiene ningún efecto cuando los procesos automáticos (SOAs cortas) están ocupados para los homógrafos.
Permissiveness in the learning and development of song syntax in swamp sparrows

Vocal learning in swamp sparrows, Melospiza georgiana, is subject to a host of sensory and motor limitations. One such limitation is that young swamp sparrows almost invariably crystallize their songs with a simple trilled syntax, irrespective of the syntax of vocal models from which they learn. A striking exception to this pattern was recently identified by Podos (1996, Animal Behaviour, 51, 1061-1070), who found that large-scale organizational changes in vocal syntax, including the production of an intermittent or 'broken' syntax, were produced when birds faced limits on vocal performance capacities during motor ontogeny. Our goal in the present study was to determine whether song models with broken syntax could serve as suitable training models for young swamp sparrows, and, if so, if broken syntax could be faithfully reproduced. We hand-reared 10 male swamp sparrows and exposed them to control, rapid and broken song models. Control song models were copied with a high degree of accuracy, as in previous studies. Rapid song models were copied with deficiencies that suggested performance limits on vocal production; such deficiencies included the production of songs with broken syntax and the production of songs in which notes were dropped out as songs progressed. Broken songs proved suitable as training models. Furthermore, copies of broken song models were crystallized either with normal or with broken syntax. These data identify an unexpected direction of permissiveness in the types of songs swamp sparrows will memorize and accurately reproduce, and also point to a possible proximate basis for syntactical changes in the evolution of sparrow songs. Copyright 1999 The Association for the Study of Animal Behaviour.