Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of data captured by barcode medication administration system using a PDA; aiming at reducing medication errors at point of care in Japanese Red Cross Kochi Hospital

Preventing medication errors by using a barcode administration system has become prevalent in patient safety. Analyses of data captured by bar code systems provide opportunities to understand the actual situation at the point of care. Our study aims at understanding issues of medication safety as well as investigating measures taken to prevent medication accidents, by analyzing data captured by a bar code system and a personal digital assistant (PDA). The barcode administration system named Point-of-Act-System implemented in Japanese Red Cross Kochi Hospital was designed to capture every activity at the bedside. Complete activity data captured by the system, which included injections, treatment and other nursing activity, as well as injection warning data, were used for our analyses. We describe the data and analyze them statistically to find potentially times of risk and to ascertain the relation between busyness and error. The injection warning rate as a whole was 6.1% on average. The results showed there was a negative correlation between the number of injections given and the injection warning rate (-0.48, p<0.05). The warning rate was low during the hours when a large number of injections were administered. The data also showed that a variation in activities being performed has a negative effect on medication safety. A bar code administration system is quite an effective way not only to prevent medication error at point of care, but also to improve patient safety through analyses of data captured by such a system.
Synthesis and Neuroprotective Action of Xyloketal Derivatives in Parkinson’s Disease Models

Parkinson’s disease (PD) is the second most common neurodegenerative disease affecting people over age 55. Oxidative stress actively participates in the dopaminergic (DA) neuron degeneration of PD. Xyloketals are a series of natural compounds from marine mangrove fungus strain No. 2508 that have been reported to protect against neurotoxicity through their antioxidant properties. However, their protection versus 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity is only modest, and appropriate structural modifications are necessary to discover better candidates for treating PD. In this work, we designed and synthesized 39 novel xyloketal derivatives (1–39) in addition to the previously reported compound, xyloketal B. The neuroprotective activities of all 40 compounds were evaluated in vivo via respiratory burst assays and longevity-extending assays. During the zebrafish respiratory burst assay, compounds 1, 9, 23, 24, 36 and 39 strongly attenuated reactive oxygen species (ROS) generation at 50 μM. In the Caenorhabditis elegans longevity-extending assay, compounds 1, 8, 15, 16 and 36 significantly extended the survival rates (p < 0.005 vs. dimethyl sulfoxide (DMSO)). A total of 15 compounds were tested for the treatment of Parkinson’s disease using the MPP+-induced C. elegans model, and compounds 1 and 8 exhibited the highest activities (p < 0.005 vs. MPP+). In the MPP+-induced C57BL/6 mouse PD model, 40 mg/kg of 1 and 8 protected against MPP+-induced dopaminergic neurodegeneration and increased the number of DA neurons from 53% for the MPP+ group to 78% and 74%, respectively (p < 0.001 vs. MPP+ group). Thus, these derivatives are novel candidates for the treatment of PD.
Processing and performance evaluation of hollow microspheres filled epoxy composites

Microspheres filled epoxy composites are fabricated, using two types of hollow glass microspheres, namely, Fillite-500 and K-15. Fillite-500 microspheres are relatively stronger and denser (avg. crushed strength ∼17 MPa and density ∼0.45 kg/m3) than K-15 microspheres (avg. crushed strength ∼2 MPa and density ∼0.15 kg/m3). Each type of microspheres in the range of 10–70 vol% are added into a low viscosity two-part epoxy resin (SC-15) system in several steps and are mixed together meticulously to avoid breakage of the microspheres during mixing. The epoxy/microspheres mixture is then cured at room temperature (about 70°F) inside an oven for 24 h followed by post curing at 200°F for 4 h. One of the objectives of this research is to determine the maximum amount of microspheres that can be mixed uniformly without aid of diluents. Microstructural examinations reveal that the microspheres are fairly distributed uniformly through out the epoxy matrix up to 70 vol% for Fillite-500 and 60 vol% for K-15. It is found that addition of microspheres results in the reduction of density of the neat epoxy up to 28% with Fillite-500 and up to 54% with K-15. Thermo mechanical analysis results show that the coefficient of thermal expansion of epoxy matrix is reduced up to 66% with Fillite-500 and up to 51% with K-15.Compressive behavior for the epoxy/Fillite-500 system is found to be different than the epoxy/K-15 system. Failure analysis results indicate that the failure processes are also different for both the systems. POLYM. COMPOS. , 2008. © 2008 Society of Plastics Engineers
Utilization of prenatal care in poorer and wealthier urban neighbourhoods in Turkey.

BACKGROUND The objectives of this study are to identify the individual- and neighbourhood-level determinants of utilization of prenatal care, and to identify self-reported reasons for not receiving prenatal care in Turkey. METHODS A household-based cluster sample of 1249 women who had a child less than two years old were interviewed in five Turkish cities. Multilevel regression analysis was run to predict the influences of individual- and neighbourhood-level characteristics on utilization of prenatal care. RESULTS Utilization of prenatal care and the quality of the care received were found to be significantly lower in poorer neighbourhoods. Using multilevel regression analysis (two levels), educational level, income, parity and having health insurance were found to be individual-level determinants, while quality of care offered and stability of the local population were found to be neighbourhood-level determinants of utilization of prenatal care. The most frequent self-reported reason for receiving no prenatal care was 'not having any complaint', and the second was 'insufficient financial resources'. CONCLUSION There was a big difference between poor and wealthy neighbourhoods in utilization of prenatal care. This difference was partly due to a contextual effect of neighbourhood status; but mostly due to individual-level variables. Improving the quality of prenatal care may increase not only the benefits of prenatal care, but also its utilization, especially in the public sector. Health and social policies have to take into account diversity among individuals and neighbourhoods in the course of efforts to improve service quality.
An Efficient Resource-constrained Global Scheduling Technique For Superscalar And Vliw Processors

We describe a new algorithm for parallelization of sequential code that eliminates anti and output dependences by renaming registers on an as-needed basis during scheduling. A dataflow attribute at the beginning of each basic block indicates what operations are available for moving up through this basic block. Scheduling consists of choosing the best operation from the set of opemtions that can move to a point, moving the instances of the opemtion to the point, making bookkeeping copies for edges that join the moving path but are not on it, and updating the dataflow attributes of basic blocks only on the paths that were tmversed by the instances of the moved opemtions. The code motions are done globally without going through atomic transformations of percolation scheduling, for better eficiency. For performing the code motions, we use an intermediate representation that is directly executable as sequential RISC code, rather than VLIW de. As a result, the new algorithm can be used to generate parallelized code for multiple ALU superscalar processors as well. The enhanced pipeline scheduling algorithm for software pipelining of arbitrary code is reformulated within the framework of the new sequential RISC representation. The new algorithm has been implemented, and preliminary results on AIX utilities indicate that it requires significantly less compilation time than the percolation scheduling approach.
Radiotelemetric Study of Habitat Use by the Arboreal Snake Hoplocephalus stephensii (Elapidae) in Eastern Australia

Abstract Simply classifying a species as “arboreal” may tell us little about the ways that it uses above-ground habitats. For example, some species of arboreal snakes select exposed positions on branches, others lie among foliage, and yet others exploit crevices within the trunk. These different structural niches may involve fundamentally different patterns not only of habitat selection criteria but also of morphological, behavioral, and ecological traits. We implanted miniature radio-transmitters in 16 adult Stephens' banded snakes (Hoplocephalus stephensii) in a forest managed for timber production in northeastern New South Wales, and relocated these snakes regularly over a two-year period to clarify their patterns of habitat use. Unlike the vast majority of Australian elapid species, H. stephensii are primarily arboreal. Radio-tracked snakes were in trees on > 80% of observations, generally hidden within hollows. The snakes remained inactive in trees for three to five months during winter each year. Snakes in wet sclerophyll forest sometimes foraged in tall sedges, whereas snakes in rain forest spent little time on the ground. Attributes of 139 trees used by the snakes were compared with those of 1437 trees in randomly selected plots. Snakes selected old, large trees with many hollows or extensive vine cover. Except for being above ground, the retreat sites used by these arboreal elapids were structurally similar to those used by their terrestrial relatives. The tree attributes important to H. stephensii thus differ profoundly from those important to many other species of arboreal snakes.
The Spectrum of Malignancies among Adult HIV Cohort in Poland between 1995 and 2012: A Retrospective Analysis of 288 Cases

The aim of the study The aim of the study was to evaluate the spectrum of AIDS-defining malignancies (ADMs) and non-AIDS-defining malignancies (NADMs) in HIV-infected patients in Poland. Material and methods A retrospective observational study was conducted among HIV-infected adult patients who developed a malignancy between 1995 and 2012 in a Polish cohort. Malignancies were divided into ADMs and NADMs. Non-AIDS-defining malignancies were further categorised as virus-related (NADMs-VR) and unrelated (NADMs-VUR). Epidemiological data was analysed according to demographic data, medical history, and HIV-related information. Results were analysed by OR, EPITools package parameters and Fisher's exact test. Results In this study 288 malignancies were discovered. The mean age at diagnosis was 41.25 years (IQR20-81); for ADMs 38.05 years, and for NADMs-VURs 46.42 years; 72.22% were male, 40.28% were co-infected with HCV. The risk behaviours were: 37.85% IDU, 33.33% MSM, and 24.31% heterosexual. Mean CD4+ at the diagnosis was 282 cells/mm3 (for ADMs 232 and for NADMs-VUR 395). Average duration of HIV infection at diagnosis was 5.69 years. There were 159 (55.2%) ADMs and 129 (44.8%) NADMs, among whom 58 (44.96%) NADMs-VR and 71 (55.04%) NADMs-VUR. The most frequent malignancies were: NHL (n = 76; 26.39%), KS (n = 49; 17.01%), ICC (n = 34; 11.81%), HD (n = 23; 7.99%), lung cancer (n = 18; 6.25%) and HCC (n = 14; 4.86%). The amount of NADMs, NADMs-VURs in particular, is increasing at present. Male gender (OR = 1.889; 95% CI: 1.104–3.233; p = 0.024), advanced age: 50–60 years (OR = 3.022; 95% CI: 1.359–6.720; p = 0.01) and ≥ 60 years (OR = 15.111; 95% CI: 3.122–73.151; p < 0.001), longer duration of HIV-infection and successful HAART (OR = 2.769; 95% CI: 1.675–4.577; p = 0) were independent predictors of NADMs overall, respectively. Conclusions In a Polish cohort NHL was the most frequent malignancy among ADMs, whereas HD was the most frequent among NADMs. Increased incidence of NADMs appearing in elderly men with longer duration of HIV-infection and with better virological and immunological control was confirmed. As HIV-infected individuals live longer, better screening strategies, especially for NADMs-VUR, are needed. The spectrum of cancer diagnoses in Poland currently does not appear dissimilar to that observed in other European populations.
Role of alginate lyase in cell detachment of Pseudomonas aeruginosa

The exopolysaccharide alginate of Pseudomonas aeruginosa was shown to be important in determining the degree of cell detachment from an agar surface. Nonmucoid strain 8822 gave rise to 50-fold more sloughed cells than mucoid strains 8821 and 8830. Alginate anchors the bacteria to the agar surface, thereby influencing the extent of detachment. The role of the P. aeruginosa alginate lyase in the process of cell sloughing was investigated. Increased expression of the alginate lyase in mucoid strain 8830 led to alginate degradation and increased cell detachment. Similar effects were seen both when the alginate lyase was induced at the initial stage of cell inoculation and when it was induced at a later stage of growth. It appears that high-molecular-weight alginate polymers are required to efficiently retain the bacteria within the growth film. When expressed from a regulated promoter, the alginate lyase can induce enhanced sloughing of cells because of degradation of the alginate. This suggests a possible role for the lyase in the development of bacterial growth films.
Microleakage around dental restorations: a summarizing review.

Although much has been accomplished during recent years, it is apparent that a great deal remains to be done for a more comprehensive understanding of the microleakage phenomenon. The techniques used in the past have contributed to a better understanding of the subject. Perhaps the future of microleakage study lies in the development of new techniques, the reapplication of old techniques, or the combination of several that have been reviewed. Use of the electron microprobe or the scanning electron microscope may provide answers to many remaining questions.
Computation of Mixed Type Functional Differential Boundary Value Problems

We study boundary value differential-difference equations where the difference terms may contain both advances and delays. Special attention is paid to connecting orbits, in particular to the model- ing of the tails after truncation to a finite interval, and we reformulate these problems as functional differential equations over a bounded domain. Connecting orbits are computed for several such prob- lems including discrete Nagumo equations, an Ising model, and Frenkel-Kontorova type equations. We describe the collocation boundary value problem code used to compute these solutions, and the numerical analysis issues which arise, including linear algebra, boundary functions and conditions, and convergence theory for the collocation approximation on finite intervals. 1. Introduction. Nonlinear spatially discrete diffusion equations occur as models in many areas of science and engineering. When the underlying mathematical models contain differ- ence terms or delays as well as derivative terms, the resulting differential-difference equations present challenging analytical and computational problems. We demonstrate how functional differential boundary value problems with advances and delays arise from such models and describe a general approach for the numerical computation of solutions. Solutions are approx- imated for several such problems, and the numerical issues arising in their computation are
Plasmodium falciparum malaria in pregnancy: Prevalence of peripheral parasitaemia, anaemia and malaria care-seeking behaviour among pregnant women attending two antenatal clinics in Edo State, Nigeria

Summary This study evaluated malaria care-seeking behaviour, as well as the prevalence of parasitaemia and anaemia among pregnant women attending antenatal clinics of two tertiary healthcare facilities in Edo State, Nigeria. Malaria was highly prevalent in the study group (20% by microscopy and estimated 25% by PCR), but parasitaemia and incidence decreased with increasing number of pregnancies. Although the level of education of the study participants was relatively high, antimalarial control measures during pregnancy were found to be poorly utilised by the women and malaria care-seeking was often delayed. A minority of the interviewed pregnant women said they had received sulphadoxine/pyrimethamine-based intermittent preventive therapy (IPT) during current pregnancy. Moreover, the use of inferior antimalaria treatment (e.g. chloroquine) was frequent. The majority of the pregnant women, mainly primigravidae, were anaemic. Efforts to improve antimalaria healthcare must be intensified, targeting pregnant women, particularly the primigravidae and secundigravidae and the healthcare providers.
Effects of Passive Finger Movement on Cortical Excitability

This study examined the effects of joint angle and passive movement direction on corticospinal excitability. The subjects were 14 healthy adults from whom consent could be obtained. We performed two experiments. In Experiment 1, we measured motor evoked potential (MEP) amplitude, F-wave and M-wave at 0° and 20° adduction during adduction or abduction movement, in the range of movement from 10° abduction to 30° adduction. In Experiment 2, MEPs were measured at static 0° and 20° adduction during passive adduction from 10° adduction to 30° adduction and static 20° adduction. MEP, F-waves and M-waves were recorded from the right first dorsal interosseous (FDI) muscle. Experiment 1 revealed significantly increased MEP amplitude at 0° during passive adduction compared to static 0° (p < 0.01). No other significant differences in MEP, M-wave and F-wave parameters were observed. In Experiment 2, MEP amplitude was significantly higher at 20° adduction during passive adduction compared with static 0° (p < 0.01). Based on these findings, it appears that fluctuations in MEP amplitude values during passive movement are not influenced by joint angle, but rather it is possible that it is due to intracortical afferent facilitation (AF) dependent on afferent input due to the start of movement and interstimulus interval (ISI) of transcranial magnetic stimulation (TMS).
The association between extreme precipitation and waterborne disease outbreaks in the United States, 1948-1994.

OBJECTIVES Rainfall and runoff have been implicated in site-specific waterborne disease outbreaks. Because upward trends in heavy precipitation in the United States are projected to increase with climate change, this study sought to quantify the relationship between precipitation and disease outbreaks. METHODS The US Environmental Protection Agency waterborne disease database, totaling 548 reported outbreaks from 1948 through 1994, and precipitation data of the National Climatic Data Center were used to analyze the relationship between precipitation and waterborne diseases. Analyses were at the watershed level, stratified by groundwater and surface water contamination and controlled for effects due to season and hydrologic region. A Monte Carlo version of the Fisher exact test was used to test for statistical significance. RESULTS Fifty-one percent of waterborne disease outbreaks were preceded by precipitation events above the 90th percentile (P = .002), and 68% by events above the 80th percentile (P = .001). Outbreaks due to surface water contamination showed the strongest association with extreme precipitation during the month of the outbreak; a 2-month lag applied to groundwater contamination events. CONCLUSIONS The statistically significant association found between rainfall and disease in the United States is important for water managers, public health officials, and risk assessors of future climate change.
Factors associated with changing efficacy of emamectin benzoate against infestations of Lepeophtheirus salmonis on Scottish salmon farms.

The availability and use of medicines to control infestations of sea lice on Atlantic salmon, Salmosalar L. , farms in Scotland has changed considerably in the last decade (Lees, Gettinby & Revie 2008b). Whereas hydrogen peroxide and organophosphate compounds were used widely throughout the 1990s and in the early 2000s, only two therapeutants have remained in common use since 2005: topical cypermethrin (Excis; Novartis Animal Health, Camberley, UK) and an oral formulation of emamectin benzoate (SLICE; Schering Plough Animal Health, Uxbridge, UK).
Dual use of a single Wilms' tumor 1 immunohistochemistry in evaluation of ovarian tumors: a preliminary study of 20 cases

Our previous studies revealed that a single Wilms' tumor 1 (WT-1) immunohistochemistry can be used to elucidate both the myoepithelial cells and blood vessels of human breast tumors. As the human ovary is rich in blood vessels, and WT-1 has been used as a biomarker for ovarian tumors, our current study attempted to assess if a single WT-1 immunohistochemistry has dual usages in evaluation of ovarian tumor and endothelial cells. Paraffin-embedded tissue sections were prepared from 20 cases of ovarian tumors. A set of four consecutive sections from each case were subjected to immunohistochemistry with a mouse monoclonal antibody against the human WT-1 protein, a well defined ovarian tumor marker, CA-125, and a endothelial cell phenotypic marker, CD34, respectively. From each case, 4-5 randomly selected fields were photographed, and expression of these molecules in the same structures were compared. Distinct WT-1 immunoreactivities were seen in both ovarian tumor and endothelial cells. Over 90% of WT-1 positive tumor and endothelial cells were positive for CA-125 and CD34, respectively. Similarly, over 90% of CA-125 or CD34 positive cells co-express WT-1 in tumor or endothelial cells, respectively. Our findings suggest that a single WT-1 immunohistochemistry can be used to assess both the tumor cells and micro-vascular density in ovarian tumors. Our findings also suggest that as WT-1 is expressed in both tumor and endothelial cells, the development of therapeutic agents to target WT-1 may provide an effective treatment option for ovarian cancer.
Hormonal factors and respiratory health in women – a review

Sex hormones appear to play an important role in the lung health of women. This is, however, poorly understood and, in most aspects, poorly investigated; and the literature has been contradictory and confusing. This review presents recent research concerning the involvement of sex hormones in respiratory health of adult women, using the population surveys European Community Respiratory Health Survey and Respiratory Health in Northern Europe.