Miracle-dz/UniFAR-FTUs huggingface dataset:
Review on Factors Affecting Targeting Accuracy of Deep Brain Stimulation Electrode Implantation between 2001 and 2015

Background: Accurate implantation of a depth electrode into the brain is of the greatest importance in deep brain stimulation (DBS), and various stereotactic systems have been developed for electrode implantation. However, an updated analysis of depth electrode implantation in the modern era of DBS is lacking. Objective: This study aims at providing an updated review on targeting accuracy of DBS electrode implantation by analyzing contemporary DBS electrode implantation operations from the perspective of precision engineering. Methods: Eligible articles with information on targeting accuracy of DBS electrode implantation were searched in the PubMed database. Results: An average targeting error of DBS electrode implantation is reported to decrease toward 1 mm; the standard deviation of targeting error is decreasing toward 0.5 mm. Targeting accuracy is not only found to be affected by individual surgical steps, but also systematically affected by the architecture of the implantation operation. Conclusion: A systematic strategy should be adopted to further improve the targeting accuracy of depth electrode implantation. Attention should be paid to optimizing the whole electrode implantation operation, which can help minimize error accumulation or amplification throughout the serially connected procedures for DBS electrode implantation.
Rollout Sampling Policy Iteration for Decentralized POMDPs

We present decentralized rollout sampling policy iteration (DecRSPI) — a new algorithm for multi-agent decision problems formalized as DEC-POMDPs. DecRSPI is designed to improve scalability and tackle problems that lack an explicit model. The algorithm uses Monte-Carlo methods to generate a sample of reachable belief states. Then it computes a joint policy for each belief state based on the rollout estimations. A new policy representation allows us to represent solutions compactly. The key benefits of the algorithm are its linear time complexity over the number of agents, its bounded memory usage and good solution quality. It can solve larger problems that are intractable for existing planning algorithms. Experimental results confirm the effectiveness and scalability of the approach.
Static and Differential Quantization Codebook Design for MIMO Precoding Systems

We treat the problem of quantization codebook design for MIMO precoding schemes. We propose a design criterion based on the capacity measure which is different from the maximum mutual-minimum-distance conventionally used to design the codebook. The latter criterion is derived from SNR maximization which is not necessarily the capacity- optimal quantization strategy. While the capacity expression does not directly define a valid distance metric for the design, a bound on the capacity expression can be used to formulate the quantization codebook design. We introduce a new distance metric on the Grassmanian manifold which is used to design the optimal precoder codebook. While the original formulation can be used for the (space) correlated channel model, we propose a differential codebook design in order to track changes in the channel statistics when the channel is correlated in time (or in frequency, e.g., across different tones in OFDM systems). Simulation results has shown considerable improvement through the proposed codebook design both for single user (SU-) and multiple user (MU-) MIMO systems.
Air Curtain Burners: A Tool for Disposal of Forest Residues

Open pile burning (OPB) forest residues have been limited due to several concerns, including atmospheric pollution, risk of fire spread, and weather conditions restrictions. Air Curtain Burner (ACB) systems could be an alternative to OPB and can avoid some of the negative effects that may result from OPB. The main objective was to compare the burning consumption rates and costs of two types of ACB machines, the S-220 and BurnBoss. In addition, we tested a hand-pile burning (HPB) consumption rate for a comparison with BurnBoss unit. The S-220’s burning consumption rates ranged between 5.7 and 6.8 green metric ton (GmT)/scheduled machine hour (SMH) at a cost between US $12.8 and US $10.8/GmT, respectively. Costs were 70% higher when using the BurnBoss unit. Burning residue consumption rates and cost of disposal were considerably different: they were highly dependent on machine size, species, and fuel age of forest residues. Particularly, BurnBoss test burned over 40% more than HPB method and produced clean burn by airflow. The results from this study suggest that ACBs can be a useful tool to dispose of forest residues piled in many forests areas with less concerns of air quality and fire escape risks.
Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice

The coupling of energy homeostasis to thermoregulation is essential to maintain homeothermy in changing external environments. We studied the role of the cold thermoreceptor TRPM8 in this interplay in mice of both sexes. We demonstrate that TRPM8 is required for a precise thermoregulation in response to cold, in fed and fasting. Trpm8−/− mice exhibited a fall of 0.7°C in core body temperature when housed at cold temperatures, and a deep hypothermia (<30°C) during food deprivation. In both situations, TRPM8 deficiency induced an increase in tail heat loss. This, together with the presence of TRPM8-sensory fibers innervating the main tail vessels, unveils a major role of this ion channel in tail vasomotor regulation. Finally, TRPM8 deficiency had a remarkable impact on energy balance. Trpm8−/− mice raised at mild cold temperatures developed late-onset obesity and metabolic dysfunction, with daytime hyperphagia and reduction of fat oxidation as plausible causal factors. In conclusion, TRPM8 fine-tunes eating behavior and fuel utilization during thermoregulatory adjustments to mild cold. Persistent imbalances in these responses result in obesity. SIGNIFICANCE STATEMENT The thermosensitive ion channel TRPM8 is required for a precise thermoregulatory response to cold and fasting, playing an important role in tail vasoconstriction, and therefore heat conservation, as well as in the regulation of ingestive behavior and metabolic fuel selection upon cooling. Indeed, TRPM8-deficient mice, housed in a mild cold environment, displayed an increase in tail heat loss and lower core body temperature, associated with the development of late-onset obesity with glucose and lipid metabolic dysfunction. A persistent diurnal hyperphagia and reduced fat oxidation constitute plausible underlying mechanisms in the background of a deficient thermoregulatory adjustment to mild cold ambient temperatures.
UNIAXIAL COMPRESSION OF UF-FETA CHEESE RELATED TO SENSORY TEXTURE ANALYSIS

Rheological characteristics of seven Feta cheeses with different textures and produced from ultrafiltered milk (UF-Feta cheeses) were evaluated by uniaxial compression and sensory texture analysis. The effect of uniaxial deformation rate (50-2500 mm/min) on four rheological parameters: Stress at fracture (σ f ), Hencky strain at fracture (e f ), deformability modulus (E) and work to fracture (W f ) was examined. Three Principal Components (PC) described 76, 16 and 4% respectively, of the variation in the uniaxial compression data set (4 parameters at 12 deformation rates). Statistically σf, E and W f described the same type of information in the data set. Six sensory texture attributes of the UF-Feta cheeses were evaluated by a sensory texture panel: nonoral firmness, nonoral brittleness, nonoral spreadability, oral crumbliness, oral firmness and oral stickiness. One PC described 93% of the variation in the sensory texture data and grouped the sensory variables into two negatively correlated groups: nonoral firmness nonoral brittleness, oral firmness and oral crumbliness versus nonoral spreadability and oral stickiness. Correlations and Partial Least Squares regression (PLS) between instrumental and sensory texture variables showed that nonoral and oral firmness were the nonoral and oral sensory variables best predicted from instrumental measurements. σ f , E and W f were all able to predict nonoral and oral firmness. Of the instrumental parameters, σf generally gave the best correlation to nonoral firmness at all deformation rates. Above a deformation rate of 50 mm/min correlations between of and nonoral firmness were almost independent of deformation rate, and at any deformation rate correlations between σ f and oral firmness were independent of deformation rate, implying that it is not necessary to do compression testing of UF-Feta cheese at the chewing rate to get a good correlation with sensory evaluation. Using four instrumental variables (σ f, e f , E and W f ) for prediction increased correlations slightly, compared to prediction using σ f alone. However, σ f was preferred as a measure for nonoral firmness because of the simplicity in modelling, and also as a measure for the total variation in the sensory texture quality of UF-Feta cheese because of the high correlations among the sensory variables.
DISTRIBUTION OF DENTAL CARIES AND ITS RELATIONSHIP TO RISK FACTORS

The aim of this study was to assess the distribution of caries in the oral cavity and its relationship to risk factors. A total of 115 patients including both males and females were randomly selected for the study. Information about risk factors was collected by face to face interviews. Oral examination was performed to evaluate distribution of caries. Descriptive statistics were used to analyze data. Mean DMFT index of the studied population was calculated to be 5.04. The value was higher in females than males. Prevalence of caries was high in the mandible as compared to maxilla. Most frequently involved teeth were first and second molars and occlusal surface was the commonly affected surface. There was a significant relationship between caries and risk factors. Distribution of dental caries in the oral cavity follows a specific pattern. Risk factors influence the caries susceptibility of the individuals.
The Effect of Changes in Physical Activity on Sedentary Behavior: Results From a Randomized Lifestyle Intervention Trial

Purpose. To investigate whether changes in physical activity (PA) have an impact on sedentary behavior (SB) during a lifestyle intervention. Design. Study design was a randomized trial. Setting/Subjects. Participants (n = 204) were individuals with low PA and high sedentary leisure screen time from the Chicago area. Intervention. Participants were randomized to either increase PA (iPA) or decrease sedentary leisure (dSED). The intervention consisted of decision support, coaching, and financial incentives. For iPA participants, the goal was at least 60 min/d of self-reported moderate-tovigorous-intensity PA (MVPA). For dSED participants the goal was less than 90 min/d of sedentary leisure screen time. Measures. Daily accelerometer-based measures of SB and bout-corrected MVPA were obtained. Analysis. Linear mixed-effects models were fit to estimate the effect of the intervention on MVPA and total SB and to estimate the effect of daily changes in MVPA on daily SB. Results. The iPA participants increased their bout-corrected MVPA by 14 min/d (p < .001) and decreased their total SB by 18 min/d (p < .001). The dSED participants did not significantly change their PA or their total SB. On days when participants exercised, each 10-minute bout of MVPA was associated with a 6-minute decrease in SB on the same day (p < .001). Conclusion. In an intervention study designed to increase MVPA, participants who increase their time spent exercising will obtain much of this time by reducing their SB.
Fish consumption and risk of all-cause and cardiovascular mortality: a dose–response meta-analysis of prospective observational studies

Abstract Objective There are some indications of regional differences in the association between fish consumption and clinical outcomes. We aimed to test the linear and potential non-linear dose–response relationships between fish consumption and risk of all-cause and cardiovascular (CVD) mortality, and possible confounding by region. Design Systematic review and dose–response meta-analysis. Setting Systematic search using PubMed and Scopus, from inception up to September 2016. Subjects Prospective observational studies reporting the estimates of all-cause and CVD mortality in relation to three or more categories of fish intake were included. Random-effects dose–response meta-analysis was conducted. Results Fourteen prospective cohort studies (ten publications) with 911 348 participants and 75 451 incident deaths were included. A 20 g/d increment in fish consumption was significantly and inversely associated with the risk of CVD mortality (relative risk=0·96; 95 % CI 0·94, 0·98; I 2=0 %, n 8) and marginally and inversely associated with the risk of all-cause mortality (relative risk=0·98; 95 % CI 0·97, 1·00; I 2=81·9 %, n 14). Subgroup analysis resulted in a significant association only in the subgroup of Asian studies, compared with Western studies, in both analyses. Analysis of Western studies suggested a nearly U-shaped association, with a nadir at fish consumption of ~20 g/d in analysis of both outcomes. Meanwhile, the associations appeared to be linear in Asian studies. Conclusions There was potential evidence of regional differences in the association between fish consumption and mortality. It may be helpful to examine the associations by considering types of fish consumed and methods of fish preparation.
Polyprotein Processing as a Determinant for In Vitro Activity of Semliki Forest Virus Replicase

Semliki Forest virus (SFV) is an arthropod-borne alphavirus that induces membrane invaginations (spherules) in host cells. These harbor the viral replication complexes (RC) that synthesize viral RNA. Alphaviruses have four replicase or nonstructural proteins (nsPs), nsP1–4, expressed as polyprotein P1234. An early RC, which synthesizes minus-strand RNA, is formed by the polyprotein P123 and the polymerase nsP4. Further proteolytic cleavage results in a late RC consisting of nsP1–4 and synthesizing plus strands. Here, we show that only the late RCs are highly active in RNA synthesis in vitro. Furthermore, we demonstrate that active RCs can be isolated from both virus-infected cells and cells transfected with the wild-type replicase in combination with a plasmid expressing a template RNA. When an uncleavable polyprotein P123 and polymerase nsP4 were expressed together with a template, high levels of minus-strand RNA were produced in cells, but RCs isolated from these cells were hardly active in vitro. Furthermore, we observed that the uncleavable polyprotein P123 and polymerase nsP4, which have previously been shown to form spherules even in the absence of the template, did not replicate an exogenous template. Consequently, we hypothesize that the replicase proteins were sequestered in spherules and were no longer able to recruit a template.
Maximizing the Expected Net Present Value of a Project with Phase-Type Distributed Activity Durations: An Efficient Globally Optimal Solution Procedure

We study projects with activities that have stochastic durations that are modeled using phase-type distributions. Intermediate cash flows are incurred during the execution of the project. Upon completion of all project activities a payoff is obtained. Because activity durations are stochastic, activity starting times cannot be defined at the start of the project. Instead, we have to rely on a policy to schedule activities during the execution of the project. The optimal policy schedules activities such that the expected net present value of the project is maximized. We determine the optimal policy using a new continuous-time Markov chain and a backward stochastic dynamic program. Although the new continuous-time Markov chain allows to drastically reduce memory requirements (when compared to existing methods), it also allows activities to be preempted; an assumption that is not always desirable. We prove, however, that it is globally optimal not to preempt activities if cash flows are incurred at the start of an activity. Moreover, this proof holds regardless of the duration distribution of the activities. A computational experiment shows that we significantly outperform current state-of-the-art procedures. On average, we improve computational efficiency by a factor of 600, and reduce memory requirements by a factor of 321.
Contribution of a Comparative Western Blot Method to Early Postnatal Diagnosis of Congenital Syphilis

ABSTRACT Serology has a pivotal role in the diagnosis of congenital syphilis (CS), but problems arise because of the passive transfer of IgG antibodies across the placenta. The aim of this study was to assess the diagnostic value of a comparative Western blot (WB) method finalized to match the IgG immunological profiles of mothers and their own babies at birth in order to differentiate between passively transmitted maternal antibodies and antibodies synthesized by the infants against Treponema pallidum. Thirty infants born to mothers with unknown or inadequate treatment for syphilis were entered in a retrospective study, conducted at St. Orsola-Malpighi Hospital, Bologna, Italy. All of the infants underwent clinical, instrumental, and laboratory examinations, including IgM WB testing. For the retrospective study, an IgG WB assay was performed by blotting T. pallidum antigens onto nitrocellulose sheets and incubating the strips with serum specimens from mother-child pairs. CS was diagnosed in 11 out of the 30 enrolled infants; 9/11 cases received the definitive diagnosis within the first week of life, whereas the remaining two were diagnosed later because of increasing serological test titers. The use of the comparative IgG WB testing performed with serum samples from mother-child pairs allowed a correct CS diagnosis in 10/11 cases. The CS diagnosis was improved by a strategy combining comparative IgG WB results with IgM WB results, leading to a sensitivity of 100%. The comparative IgG WB test is thus a welcome addition to the conventional laboratory methods used for CS diagnosis, allowing identification and adequate treatment of infected infants and avoiding unnecessary therapy of uninfected newborns.
Epigenetics and Trained Immunity.

SIGNIFICANCE A growing body of clinical and experimental evidence has challenged the traditional understanding that only the adaptive immune system can mount immunological memory. Recent findings describe the adaptive characteristics of the innate immune system, underscored by its ability to remember antecedent foreign encounters and respond in a nonspecific sensitized manner to reinfection. This has been termed trained innate immunity. Although beneficial in the context of recurrent infections, this might actually contribute to chronic immune-mediated diseases, such as atherosclerosis. Recent Advances: In line with its proposed role in sustaining cellular memories, epigenetic reprogramming has emerged as a critical determinant of trained immunity. Recent technological and computational advances that improve unbiased acquisition of epigenomic profiles have significantly enhanced our appreciation for the complexities of chromatin architecture in the contexts of diverse immunological challenges. CRITICAL ISSUES Key to resolving the distinct chromatin signatures of innate immune memory is a comprehensive understanding of the precise physiological targets of regulatory proteins that recognize, deposit, and remove chemical modifications from chromatin as well as other gene-regulating factors. Drawing from a rapidly expanding compendium of experimental and clinical studies, this review details a current perspective of the epigenetic pathways that support the adapted phenotypes of monocytes and macrophages. FUTURE DIRECTIONS We explore future strategies that are aimed at exploiting the mechanism of trained immunity to improve the prevention and treatment of infections and immune-mediated chronic disorders.
A randomised control trial of walking to ameliorate brain injury fatigue: a NIDRR TBI model system centre-based study

ABSTRACT Fatigue is one of the most commonly reported sequelae after traumatic brain injury (TBI). This study evaluated the impact of a graduated physical activity programme on fatigue after TBI. Using a prospective randomised single-blind crossover design, 123 individuals with TBI, over the age of 18, were enrolled. Interventions included a home-based walking programme utilising a pedometer to track daily number of steps at increasing increments accompanied by tapered coaching calls over a 12-week period. Nutritional counselling with the same schedule of coaching calls served as the control condition. Main outcome measures included: the Global Fatigue Index (GFI), the Barrow Neurological Institute (BNI) Fatigue Scale Overall Severity Index Score, and the Multidimensional Fatigue Inventory (MFI). Step counts improved over time regardless of group assignment. The walking intervention led to a decrease in GFI, BNI Total, and MFI General scores. Participants reported less fatigue at the end of the active part of the intervention (24 weeks) and after a wash out period (36 weeks) as measured by the BNI Overall. The study suggests that walking can be used as an efficient and cost-effective tool to improve fatigue in persons who have sustained a TBI.
Associations of Eating Two Breakfasts With Childhood Overweight Status, Sociodemographics, and Parental Factors Among Preschool Students

Background. School breakfast may contribute to increased risk for obesity because children may be consuming two breakfasts: at home and at school. The purpose of this study is to determine the prevalence of preschoolers consuming two breakfasts and to assess relationships with overweight/obesity and other factors. Method. Head Start parents (n = 273, 84.6% Hispanic) in the southwest completed cross-sectional surveys on child breakfast patterns and parental perceptions of school breakfast and personal breakfast consumption habits. Surveys were linked with sociodemographics and body mass index in Head Start databases in 2013. General estimating equation binomial models (schools as a random effect) were used to assess the relationship between two breakfasts (at home and school) and key variables, adjusting for gender, race, ethnicity, and household income. Results. The prevalence of consuming two breakfasts was 34%. Children’s overweight/obesity status was inversely related to two-breakfast consumption, but it was significant only for the Hispanic subgroup; the odds of being overweight/obese was 60% lower among those who ate two breakfasts (p < .05). The likelihood of consuming a second breakfast increased over twofold among children who woke up before 7 a.m. (p = .004). Among Hispanic families, a significant association was observed between children’s two-breakfast consumption and parental perceptions about whether they perceived the breakfast at Head Start was culturally appropriate (p = .040). Conclusions. Not only was eating two breakfast not associated with obesity, the association was in the opposite of the expected direction and significant for Hispanic participants. Factors such as earlier wake-up time were related to reports of two breakfast intake. While more research is needed, these findings provide information for policy makers and practitioners; caution should be exercised when suggesting that breakfast programs may be related to the consumption of two breakfasts and the risk for childhood obesity, particularly among the preschool students in this study.