Miracle-dz/UniFAR-FTUs huggingface dataset:
Adjunctive treatment for cognitive impairment in patients with chronic schizophrenia: a double-blind, placebo-controlled study

Cognitive impairment is closely related to real-life functioning in patients with schizophrenia. The aim of the present study was to evaluate the effects of adjunctive treatment with donepezil on cognition in patients with chronic schizophrenia. This was a 12-week, double-blind, randomized, placebo-controlled study of donepezil as an adjunct to antipsychotic drug therapy in patients with chronic stable schizophrenia. Sixty-one subjects were randomized to receive donepezil 5 mg/day (n=31) and/or placebo (n=30). A nine-test neuropsychological assessment battery was administered at baseline and at the end of the study. At the 12-week end point, the donepezil group showed significant improvements in the Wechsler Memory Scale Third Edition Spatial Span, Brief Visuospatial Memory Test total recall and delayed recall, Trail-Making Test Part A, and Category Fluency Test-animal naming (all P≤0.018). Compared with placebo, donepezil was associated with significant improvement in several cognitive domains, including working memory, speed of information processing, and visual learning and memory (P≤0.008). The results of the present study suggest that adjunctive use of donepezil is beneficial for improving cognitive function in patients with schizophrenia.
TREC 2007 Spam Track Overview

TREC’s Spam Track uses a standard testing framework that presents a set of chronologically ordered email messages a spam filter for classification. In the filtering task, the messages are presented one at at time to the filter, which yields a binary judgement (spam or ham [i.e. non-spam]) which is compared to a humanadjudicated gold standard. The filter also yields a spamminess score, intended to reflect the likelihood that the classified message is spam, which is the subject of post-hoc ROC (Receiver Operating Characteristic) analysis. Four different forms of user feedback are modeled: with immediate feedback the gold standard for each message is communicated to the filter immediately following classification; with delayed feedback the gold standard is communicated to the filter sometime later (or potentially never), so as to model a user reading email from time to time and perhaps not diligently reporting the filter’s errors; with partial feedback the gold standard for only a subset of email recipients is transmitted to the filter, so as to model the case of some users never reporting filter errors; with active on-line learning (suggested by D. Sculley from Tufts University [5]) the filter is allowed to request immediate feedback for a certain quota of messages which is considerably smaller than the total number. Two test corpora – email messages plus gold standard judgements – were used to evaluate subject filters. One public corpus (trec07p) was distributed to participants, who ran their filters on the corpora using a track-supplied toolkit implementing the framework and the four kinds of feedback. One private corporus (MrX 3) was not distributed to participants; rather, participants submitted filter implementations that were run, using the toolkit, on the private data. Twelve groups participated in the track, each submitting up to four filters for evaluation in each of the four feedback modes (immediate; delayed; partial; active).
Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2

Background The lactogenic hormones prolactin (PRL) and placental lactogens (PL) play central roles in reproduction and mammary development. Their actions are mediated via binding to PRL receptor (PRLR), highly expressed in brown adipose tissue (BAT), yet their impact on adipocyte function and metabolism remains unclear. Methodology/Principal Findings PRLR knockout (KO) newborn mice were phenotypically characterized in terms of thermoregulation and their BAT differentiation assayed for gene expression studies. Derived brown preadipocyte cell lines were established to evaluate the molecular mechanisms involved in PRL signaling on BAT function. Here, we report that newborn mice lacking PRLR have hypotrophic BAT depots that express low levels of adipocyte nuclear receptor PPARγ2, its coactivator PGC-1α, uncoupling protein 1 (UCP1) and the β3 adrenoceptor, reducing mouse viability during cold challenge. Immortalized PRLR KO preadipocytes fail to undergo differentiation into mature adipocytes, a defect reversed by reintroduction of PRLR. That the effects of the lactogens in BAT are at least partly mediated by Insulin-like Growth Factor-2 (IGF-2) is supported by: i) a striking reduction in BAT IGF-2 expression in PRLR KO mice and in PRLR-deficient preadipocytes; ii) induction of cellular IGF-2 expression by PRL through JAK2/STAT5 pathway activation; and iii) reversal of defective differentiation in PRLR KO cells by exogenous IGF-2. Conclusions Our findings demonstrate that the lactogens act in concert with IGF-2 to control brown adipocyte differentiation and growth. Given the prominent role of brown adipose tissue during the perinatal period, our results identified prolactin receptor signaling as a major player and a potential therapeutic target in protecting newborn mammals against hypothermia.
Evaluating the role of spectral and envelope characteristics in the intelligibility advantage of clear speech.

In adverse listening conditions, talkers can increase their intelligibility by speaking clearly [Picheny, M.A., et al. (1985). J. Speech Hear. Res. 28, 96-103; Payton, K. L. , et al. (1994). J. Acoust. Soc. Am. 95, 1581-1592]. This modified speaking style, known as clear speech, is typically spoken more slowly than conversational speech [Picheny, M. A. , et al. (1986). J. Speech Hear. Res. 29, 434-446; Uchanski, R. M. , et al. (1996). J. Speech Hear. Res. 39, 494-509]. However, talkers can produce clear speech at normal rates (clear/normal speech) with training [Krause, J. C. , and Braida, L. D. (2002). J. Acoust. Soc. Am. 112, 2165-2172] suggesting that clear speech has some inherent acoustic properties, independent of rate, that contribute to its improved intelligibility. Identifying these acoustic properties could lead to improved signal processing schemes for hearing aids. Two global-level properties of clear/normal speech that appear likely to be associated with improved intelligibility are increased energy in the 1000-3000-Hz range of long-term spectra and increased modulation depth of low-frequency modulations of the intensity envelope [Krause, J. C. , and Braida, L. D. (2004). J. Acoust. Soc. Am. 115, 362-378]. In an attempt to isolate the contributions of these two properties to intelligibility, signal processing transformations were developed to manipulate each of these aspects of conversational speech independently. Results of intelligibility testing with hearing-impaired listeners and normal-hearing listeners in noise suggest that (1) increasing energy between 1000 and 3000 Hz does not fully account for the intelligibility benefit of clear/normal speech, and (2) simple filtering of the intensity envelope is generally detrimental to intelligibility. While other manipulations of the intensity envelope are required to determine conclusively the role of this factor in intelligibility, it is also likely that additional properties important for highly intelligible speech at normal speech at normal rates remain to be identified.
Evidence for nonvectorial, retrograde transferrin trafficking in the early endosomes of HEp2 cells

We have previously characterized the trafficking of transferrin (Tf) through HEp2 human carcinoma cells (Ghosh, R. N., D. L. Gelman, and F. R. Maxfield, 1994. J. Cell Sci. 107:2177-2189). Early endosomes in these cells are comprised of both sorting endosomes and recycling compartments, which are distinct separate compartments. Endocytosed Tf initially appears in punctate sorting endosomes that also contain recently endocytosed LDL. After short loading pulses, Tf rapidly sorts from LDL with first-order kinetics (t1/2 approximately 2.5 min), and it enters the recycling compartment before leaving the cell (t1/2 approximately 7 min). Here, we report a second, slower rate for Tf to leave sorting endosomes after HEp2 cells were labeled to steady state with fluorescein Tf instead of the brief pulse used previously. We determined this rate using digital image analysis to measure the Tf content of sorting endosomes that also contained LDL. With an 11-min chase, the Tf in sorting endosomes was 24% of steady-state value. This was in excess of the amount expected (5% of steady state) from the rate of Tf exit after short filling pulses. The excess could not be accounted for by reinternalization of recycled cell surface Tf, implying that either some Tf was retained in sorting endosomes, or that Tf was delivered back to the sorting endosomes from the recycling compartment. The former is unlikely since nearly all sorting endosomes contain detectable Tf after an 11-min chase, even though more than one third of the sorting endosomes were formed during the chase time. Furthermore, while observing living cells by confocal microscopy, we saw vesicle movements that appeared to be fluorescent Tf returning from recycling compartments to sorting endosomes. The slow rate of exit after steady-state labeling was similar to the Tf exit rate from the cell, suggesting an equilibration of Tf throughout the early endosomal system by this retrograde pathway. This retrograde traffic may be important for delivering molecules from the recycling compartment, which is a long-lived organelle, to sorting endosomes, which are transient.
Knowledge, Attitude and Practices on HIV/AIDS among Students of Bahir Dar University

Background: Students of higher education are more likely to be at risk of HIV/AIDS. Insufficient knowledge, less favorable attitudes and risky sexual practices are the major hindrances to prevent the spread of HIV. Thus, the aim of this study was to assess HIV related knowledge, attitude and practices (KAPs) of University students in Bahir Dar. Methods: A cross sectional study was conducted from January to March/ 2013. A structured questionnaire was used to collect sociodemographic variables and KAPs of students. Mean score and percentage were used to determine the level of KAP. Bivariate analysis was used to compute P- value, odds ratio and Confidence interval. Multivariate analysis was done to correlate KAPs with sociodemographic variables. Authors guided self-administered data collection technique was used. Results: From 817 participants, 45.7% were knowledgeable towards HIV/AIDS. The majority (82.8%) had favorable attitude. Knowledgeable students had more favorable attitudes compared to not-knowledgeable students (87.6% vs 78.6%). Good practices towards HIV/AIDS were observed among 41.7% of respondents. The majority (80.5%) of participants were not confident to discuss about condom use by demonstration. Students who were Knowledgeable and had favorable attitude had a better preventive practices towards HIV/AIDS compared to students who are not-knowledgeable and those who had unfavorable attitudes respectively. Differences in level of education, sex and religion were among the sociodemographic variables that showed statistically significant association with the one or more of the outcome variables. Conclusion: The majority of participating University students were not knowledgeable, had favorable attitude and poor practices towards HIV/AIDS. The study highlighted misconceptions about preventive methods of HIV transmission and risky sexual practices which need to be addressed. Therefore, specified, focused, continued and strengthened education on HIV/AIDS-related issues to bring change in practices, along with knowledge and attitudes has to be given.
Effect of direct-fed fibrolytic enzymes on the digestive characteristics of a forage-based diet fed to beef steers.

A study was conducted to examine the method of delivery of a solution containing cellulases and xylanases on the digestion of a forage-based diet. Five ruminally cannulated beef steers (536 kg BW) were randomly assigned to a control (CON) or one of four enzyme treatments in a 5 x 5 Latin square experiment. Steers were fed a 70:30 (DM basis) grass hay:barley diet. Enzyme-treated rations contained a solution of fibrolytic enzymes at the rate of 1.65 mL/kg of forage DM. Enzyme application treatments were 1) enzyme to forage 24 h before feeding (F-24), 2) enzyme to forage 0 h before feeding (F-0), 3) enzyme to barley 0 h before feeding (B-0), and 4) enzyme infused ruminally 2 h after feeding (RI). Dry matter and NDF intakes were not different (P > .10) across treatments. Ruminal pH was lower and total VFA concentration at 16 h after-feeding was greater (P < .10) for steers fed enzyme treatments compared with CON. Rate of NDF disappearance was greater (P < .05) for enzyme-treated than for untreated grass substrate. Ruminal infusion of enzymes compared with F-24 and F-0 produced lower disappearance of DM at 8 and 32 h (P < .10), NDF at 32 h (P < .10), and DM and NDF at 96 h (P < .05). Rate of DM disappearance of enzyme-treated grass hay was greater (P < .10) for steers fed B-0 than for those fed F-24 and F-0 and for CON than for F-24 and F-0. Total tract digestibility of DM, NDF, and ADF was greater (P < .10) for F-24 and F-0 than for CON. Forage transit time was shorter (P < .10) for B-0 than for F-24 and F-0; however, all other contrasts for particulate passage did not differ (P > .10). Results from this study indicate that direct application of enzymes to forages is capable of improving forage digestion.
The Advanced Computing Systems Association Linking Programs in a Single Address Space Linking Programs in a Single Address Space

Linking and loading are the final steps in preparing a program for execution. This paper assesses issues concerning dynamic and static linking in traditional as well as single-address-space operating systems (SASOS). Related loading issues are also addressed. We present the dynamic linking model implemented in the Mungi SASOS and discuss its strengths and limitations. Bench-marking shows that dynamic linking in a SASOS carries significantly less overhead than dynamic linking in SGI's Irix operating system. The same performance advantages could be achieved in Unix systems, if they reserved a portion of the address space for dynamically linked libraries, and ensured that each library is always mapped at the same address.
Epstein–Barr virus and post‐transplant lymphoproliferative disease

Abstract: There is convincing evidence that Epstein–Barr virus (EBV) is associated with post‐transplant lymphoproliferative disease (PTLD). Primary EBV infection following transplantation occurs in as many as 90% of cases of PTLD in children and pretransplant EBV seronegativity is a recognized risk factor for developing PTLD. Other risk factors include young age at the time of transplant, the type of transplant that the recipient receives and the type and intensity of immunosuppression. The clinical presentation is often nonspecific and tissue biopsy is necessary to establish the diagnosis. There appears to be a correlation between PTLD and EBV viral load measured by polymerase chain reaction (PCR) of the peripheral blood and quantitative PCR may be a useful guide in the management of PTLD. Antiviral drugs and cytomegalovirus‐immunoglobulin G may have a role in preventing PTLD. Because PTLD results from functional over‐immunosuppression, the initial treatment is reduction of immunosuppression. Antiviral agents, interferon, immuno‐based monoclonal therapy, cell‐based therapy and chemotherapy also have a potential role in treating this disorder. At the present time there is no standardized approach to the evaluation and treatment of PTLD.
Refinancing Risk and Cash Holdings: Refinancing Risk and Cash Holdings

Although a firm’s use of shorter-term debt can potentially help it to reduce agency costs of debt and align managers’ interests with those of shareholders, the use of this type of debt increases the firm’s refinancing risk. We hypothesize that firms with debt that has a shorter maturity hold larger cash reserves to reduce important costs they could incur if they have difficulty refinancing their debt. Using a simultaneous equations framework that accounts for the joint determination of cash holdings and debt maturity, we find that firms that shorten (lengthen) the maturity of their debt increase (decrease) their cash holdings. Additionally, we document that U.S. firms have markedly shortened the maturity of their debt over the 1980-2008 period and that this can explain a large fraction of the increase in the cash holdings of these firms over this period. We also show that the market value of a dollar of cash holdings is higher for firms whose debt has a shorter maturity. Further, the inverse associations between the maturity of a firm’s debt with the level and market value of its cash holdings are more pronounced during periods when credit market conditions are tighter and refinancing risk is consequently higher. Finally, we show that larger cash holdings help to mitigate underinvestment problems resulting from refinancing risk. Overall, our findings suggest that refinancing risk is a key determinant of corporate cash holdings. * We thank Malcolm Baker, Travis Box, Murillo Campello, Amar Gande, Kathy Kahle, Swaminathan Kalpathy, and seminar participants at McGill University, Texas Tech University, Virginia Tech University, the University of Arizona, and the 2011 University of Innsbruck – Financial Markets and Risk conference for helpful comments. We also thank Douglas Fairhurst for excellent research assistance.
Electrocardiographic Abnormalities in Trypanosoma cruzi Seropositive and Seronegative Former Blood Donors

Background Blood donor screening leads to large numbers of new diagnoses of Trypanosoma cruzi infection, with most donors in the asymptomatic chronic indeterminate form. Information on electrocardiogram (ECG) findings in infected blood donors is lacking and may help in counseling and recognizing those with more severe disease. Objectives To assess the frequency of ECG abnormalities in T.cruzi seropositive relative to seronegative blood donors, and to recognize ECG abnormalities associated with left ventricular dysfunction. Methods The study retrospectively enrolled 499 seropositive blood donors in São Paulo and Montes Claros, Brazil, and 483 seronegative control donors matched by site, gender, age, and year of blood donation. All subjects underwent a health clinical evaluation, ECG, and echocardiogram (Echo). ECG and Echo were reviewed blindly by centralized reading centers. Left ventricular (LV) dysfunction was defined as LV ejection fraction (EF)<0.50%. Results Right bundle branch block and left anterior fascicular block, isolated or in association, were more frequently found in seropositive cases (p<0.0001). Both QRS and QTc duration were associated with LVEF values (correlation coefficients −0.159,p<0.0003, and −0.142,p = 0.002) and showed a moderate accuracy in the detection of reduced LVEF (area under the ROC curve: 0.778 and 0.790, both p<0.0001). Several ECG abnormalities were more commonly found in seropositive donors with depressed LVEF, including rhythm disorders (frequent supraventricular ectopic beats, atrial fibrillation or flutter and pacemaker), intraventricular blocks (right bundle branch block and left anterior fascicular block) and ischemic abnormalities (possible old myocardial infarction and major and minor ST abnormalities). ECG was sensitive (92%) for recognition of seropositive donors with depressed LVEF and had a high negative predictive value (99%) for ruling out LV dysfunction. Conclusions ECG abnormalities are more frequent in seropositive than in seronegative blood donors. Several ECG abnormalities may help the recognition of seropositive cases with reduced LVEF who warrant careful follow-up and treatment.
Working memory capacity and fluid abilities: the more difficult the item, the more more is better

The relationship between fluid intelligence and working memory is of fundamental importance to understanding how capacity-limited structures such as working memory interact with inference abilities to determine intelligent behavior. Recent evidence has suggested that the relationship between a fluid abilities test, Raven's Progressive Matrices, and working memory capacity (WMC) may be invariant across difficulty levels of the Raven's items. We show that this invariance can only be observed if the overall correlation between Raven's and WMC is low. Simulations of Raven's performance revealed that as the overall correlation between Raven's and WMC increases, the item-wise point bi-serial correlations involving WMC are no longer constant but increase considerably with item difficulty. The simulation results were confirmed by two studies that used a composite measure of WMC, which yielded a higher correlation between WMC and Raven's than reported in previous studies. As expected, with the higher overall correlation, there was a significant positive relationship between Raven's item difficulty and the extent of the item-wise correlation with WMC.
Behavioral Evidence for Differences in Social and Non-Social Category Learning

When meeting someone for the very first time one spontaneously categorizes the seen person on the basis of his/her appearance. Categorization is based on the association between some physical features and category labels that can be social (character trait…) or non-social (tall, thin). Surprisingly little is known about how such associations are formed, particularly in the social domain. Here, we aimed at testing whether social and non-social category learning may be dissociated. We presented subjects with a large number of faces that had to be rated according to social or non-social labels, and induced an association between a facial feature (inter-eye distance) and the category labels using two different procedures. In a first experiment, we used a feedback procedure to reinforce the association; behavioral measures revealed an association between the physical feature manipulated and abstract non-social categories, while no evidence for an association with social labels could be found. In a second experiment, we used passive exposure to the association between physical features and labels; we obtained behavioral evidence for learning of both social and non-social categories. These results support the view of the specificity of social category learning; they suggest that social categories are best acquired through unsupervised procedures that can be considered as a simplified proxy for group transmission.