Miracle-dz/UniFAR-FTUs huggingface dataset:
Locally Weighted Ensemble Clustering

Due to its ability to combine multiple base clusterings into a probably better and more robust clustering, the ensemble clustering technique has been attracting increasing attention in recent years. Despite the significant success, one limitation to most of the existing ensemble clustering methods is that they generally treat all base clusterings equally regardless of their reliability, which makes them vulnerable to low-quality base clusterings. Although some efforts have been made to (globally) evaluate and weight the base clusterings, yet these methods tend to view each base clustering as an individual and neglect the local diversity of clusters inside the same base clustering. It remains an open problem how to evaluate the reliability of clusters and exploit the local diversity in the ensemble to enhance the consensus performance, especially, in the case when there is no access to data features or specific assumptions on data distribution. To address this, in this paper, we propose a novel ensemble clustering approach based on ensemble-driven cluster uncertainty estimation and local weighting strategy. In particular, the uncertainty of each cluster is estimated by considering the cluster labels in the entire ensemble via an entropic criterion. A novel ensemble-driven cluster validity measure is introduced, and a locally weighted co-association matrix is presented to serve as a summary for the ensemble of diverse clusters. With the local diversity in ensembles exploited, two novel consensus functions are further proposed. Extensive experiments on a variety of real-world datasets demonstrate the superiority of the proposed approach over the state-of-the-art.
The Expression and Significance of Angiopoietin-2 and Glucose Regulated Protein 78 in Colorectal Cancer

Colorectal cancer (CRC) is a severe health problem all over the world. To detect expression of Angiopoietin-2 (Ang-2) and Glucose Regulated Protein78 (GRP78) in colorectal carcinoma tissues, and their correlation with clinical pathological features, we examine expression of Ang-2 and GRP78 by immunohistochemical staining of paraffin-embedded tumor specimens from 70 colorectal cancer patients who underwent curative surgery at Qingdao Central Hospital. Through this experiment, the correlation of Ang-2 and GRP78 expression with clinicopathological parameters of colorectal cancer was analyzed. Ang-2 and GRP78 expression were detected in 68.57% and 74.29% of colorectal carcinoma respectively (P<0.05). Expression of Ang-2 and GRP78 were highly related to differentiation degree, lymph node metastasis, and clinical stages (P<0.05), but no significant correlation to the patients’ age, gender or the site and size of the lump was detected (P>0.05). Ang-2 and GRP78 are over-expressed in colorectal cancer, representing a molecular marker for malignant degree and infiltration metastasis of colorectal cancer. They play an important role in the occurrence and progression of colorectal cancer, thus providing new targets for targeted therapy of colorectal cancer.
Brain structural alterations in obese children with and without Prader‐Willi Syndrome

Prader‐Willi syndrome (PWS) is a genetic imprinting disorder that is mainly characterized by hyperphagia and childhood obesity. Previous neuroimaging studies revealed that there is a significant difference in brain activation patterns between obese children with and without PWS. However, whether there are differences in the brain structure of obese children with and without PWS remains elusive. In the current study, we used T1‐weighted and diffusion tensor magnetic resonance imaging to investigate alterations in the brain structure, such as the cortical volume and white matter integrity, in relation to this eating disorder in 12 children with PWS, 18 obese children without PWS (OB) and 18 healthy controls. Compared with the controls, both the PWS and OB groups exhibited alterations in cortical volume, with similar deficit patterns in 10 co‐varying brain regions in the bilateral dorsolateral and medial prefrontal cortices, right anterior cingulate cortex, and bilateral temporal lobe. The white matter integrities of the above regions were then examined with an analysis method based on probabilistic tractography. The PWS group exhibited distinct changes in the reduced fractional anisotropy of white matter fibers connected to the co‐varying regions, whereas the OB group did not. Our findings indicated that PWS and OB share similar gray matter alterations that are responsible for the development of eating disorders. Additionally, the distinct white matter alterations might explain the symptoms associated with food intake in PWS, including excessive hyperphagia and constant hunger. Hum Brain Mapp 38:4228–4238, 2017. © 2017 Wiley Periodicals, Inc.
Give Me a Chance! Sense of Opportunity Inequality Affects Brain Responses to Outcome Evaluation in a Social Competitive Context: An Event-Related Potential Study

People are strongly motivated to pursue social equality during social interactions. Previous studies have shown that outcome equality influences the neural activities of monetary feedback processing in socioeconomic games; however, it remains unclear whether perception of opportunity equality affects outcome evaluation even when outcomes are maintained equal. The current study investigated the electrophysiological activities of outcome evaluation in different instructed opportunity equality conditions with event-related potentials (ERPs). Participants were asked to play a competitive dice game against an opponent to win money. Opportunity equality was manipulated in three conditions, depending on whether participants were allowed the opportunity to throw less, equal, or more dice compared to their opponents. Although participants received a winning outcome with approximately 50% chance in all equality conditions, they selectively exhibited sensitivity to the less-dice condition by reporting stronger feelings of unfairness and unpleasantness than in the equal and more-dice conditions. In line with the behavioral results, larger reward positivity amplitudes were elicited by the monetary outcome in the less-dice condition than in the other two conditions, reflecting intensified reward prediction error (RPE) signals under negative emotional arousal. Further, P3 amplitudes were enhanced following reward feedback only in the unequal conditions, perhaps due to the high-level motivational and affective processing associated with resolving conflict between social norms and self-interest. The present findings elucidate the complex temporal course of outcome evaluation processes in different opportunity equality conditions.
Vertical Distraction Osteogenesis Combined With Bilateral 2-Step Osteotomy for Preprosthetic Rehabilitation of Edentulous Mandible

AbstractThe aim of the current study was to appraise the effectiveness of distraction osteogenesis combined with bilateral 2-step osteotomy for the vertical augmentation of atrophic edentulous mandibles.To verify the predictability of this technique, we evaluated bone density and vertical bone gain of a cohort of 27 patients.The intraoral alveolar distractor was placed in the symphyseal area; then, it was left in situ for 2 months after surgery to consolidate the newly formed bone. A total of 189 implants were inserted. The main complications’ issue was tied up to the neurosensory disturbances of the inferior alveolar nerve, which disappeared few months after the surgery.At the end of the distraction osteogenesis, a mean vertical bone gain of 10.5 mm evaluated by comparing preoperative and postoperative computed tomography was reached. Three months after the surgery, the radiologic data indicated that the difference in the mean bone density, recorded in Hounsfield units (HU), between the distracted bone and the preexisting mandibular bone was not statistically significant (P > 0.05). The last measurements done showed that the osseous density in the distraction chamber was higher than the original medullary bone density: the regenerated bones were more dense (876.8 [205.9] HU) than the preexisting medullary bone (312.1 [142.3] HU) and less dense than the preexisting cortical bone (1721.1 [170.4] HU) at the ninth month.In conclusion, this approach appeared to be a viable solution for the improvement of vertical volume in atrophic mandibles.
High-Performance Sparse Matrix-Matrix Products on Intel KNL and Multicore Architectures

Sparse matrix-matrix multiplication (SpGEMM) is a computational primitive that is widely used in areas ranging from traditional numerical applications to recent big data analysis and machine learning. Although many SpGEMM algorithms have been proposed, hardware specific optimizations for multi- and many-core processors are lacking and a detailed analysis of their performance under various use cases and matrices is not available. We firstly identify and mitigate multiple bottlenecks with memory management and thread scheduling on Intel Xeon Phi (Knights Landing or KNL). Specifically targeting multi- and many-core processors, we develop a hash-table-based algorithm and optimize a heap-based shared-memory SpGEMM algorithm. We examine their performance together with other publicly available codes. Different from the literature, our evaluation also includes use cases that are representative of real graph algorithms, such as multi-source breadth-first search or triangle counting. Our hash-table and heap-based algorithms are showing significant speedups from libraries in the majority of the cases while different algorithms dominate the other scenarios with different matrix size, sparsity, compression factor and operation type. We wrap up in-depth evaluation results and make a recipe to give the best SpGEMM algorithm for target scenario. A critical finding is that hash-table-based SpGEMM gets a significant performance boost if the nonzeros are not required to be sorted within each row of the output matrix.
City, University of London Institutional Repository

The response of the seat-type abutment-backfill system under a dynamic excitation and its contribution to the structural system of the entire bridge is usually ignored in practice in Eu-rope, since the designers prefer providing joint gap sizes larger than the required for the design earthquake. In the high seismic hazard areas of the US, various versions of Caltrans Guidelines prescribe a relatively simple way to account for the abutment – backfill interaction. However, the design of Caltrans abutments is based on the ‘fully sacrificial’ approach, wherein the backwall ‘shears off’ at an early stage, while in other countries the detailing of the deck-abutment interface is such that a plastic hinge forms at the base of the backwall which is detailed for ductile behaviour. In all cases, if assessment of the bridge safety beyond the design earthquake is sought (e.g. in fragility analysis), it is essential to properly account for the response of the bridge when the end joint is closed. This paper focuses on seat-type abutments with backwall hinging. In a practical context, a ‘simple’ model in this case consists of a spring-gap element that models the entire abutment-backfill system, while a ‘complex’ model includes explicit modelling of the abutment using beam-column elements, and of the backfill behind it using one or multiple soil springs. For dynamic response-history analysis, dashpots for modelling radiation damping. issues of the arrangement of the spring-dashpot their nonlinear 2000 is used for analysing a typical overpass bridge with seat-type abutments and joints in both the longitudinal and transverse directions, for a number of spectrum compatible records. A series of pushover analyses of the ‘complex’ model are also carried out; their output can be used to define the (single) spring properties of the simple model. Interesting conclusions are drawn, both with regard to the spring configuration and to the difficulties in combining the various nonlinear elements in SAP 2000.
DDR1 and DDR2 physical interaction leads to signaling interconnection but with possible distinct functions

ABSTRACT Discoidin domain receptors 1 and 2 (DDR1 and DDR2) are members of the tyrosine kinase receptors activated after binding with collagen. DDRs are implicated in numerous physiological and pathological functions such as proliferation, adhesion and migration. Little is known about the expression of the two receptors in normal and cancer cells and most of studies focus only on one receptor. Western blot analysis of DDR1 and DDR2 expression in different tumor cell lines shows an absence of high co-expression of the two receptors suggesting a deleterious effect of their presence at high amount. To study the consequences of high DDR1 and DDR2 co-expression in cells, we over-express the two receptors in HEK 293T cells and compare biological effects to HEK cells over-expressing DDR1 or DDR2. To distinguish between the intracellular dependent and independent activities of the two receptors we over-express an intracellular truncated dominant-negative DDR1 or DDR2 protein (DDR1DN and DDR2DN). No major differences of Erk or Jak2 activation are found after collagen I stimulation, nevertheless Erk activation is higher in cells co-expressing DDR1 and DDR2. DDR1 increases cell proliferation but co-expression of DDR1 and DDR2 is inhibitory. DDR1 but not DDR2 is implicated in cell adhesion to a collagen I matrix. DDR1, and DDR1 and DDR2 co-expression inhibit cell migration. Moreover a DDR1/DDR2 physical interaction is found by co-immunoprecipitation assays. Taken together, our results show a deleterious effect of high co-expression of DDR1 and DDR2 and a physical interaction between the two receptors.
Effect of Silicon on the Tolerance of Wheat (Triticum aestivum L.) to Salt Stress at Different Growth Stages: Case Study for the Management of Irrigation Water

This paper aims to determine the most tolerant growth stage(s) of wheat to salinity stress with the addition of silicon. The aim was to investigate whether saline water could be used instead of good quality water for irrigation without implicating a greater risk to crop production. Local wheat cv. Gimmiza 11 was germinated and grown in sand cultures. Four different NaCl salinity levels were used as treatments: 0, 60, 90 and 120 mM. This was in the presence of 0 and 0.78 mM Si which added as sodium meta- silicate (Na2SiO3·9H2O). Both the NaCl and Si treatments were carried out using a full strength nutrient solution that was adjusted at pH 6.0 and used for irrigation in four replications. The application of Si with the saline nutrient media significantly enhanced superoxide dismutase (SOD) and catalase (CAT) activities in plant leaves at the booting stage compared to the other stages. This was associated with a marked decline in the H2O2 content. At the booting stage, the Si treatment promoted CAT activity in 120 mM NaCl-stressed leaves compared to the leaves treated with only 120 mM NaCl solution. SOD showed greater prevalence at the booting stage when Si was added into the saline media, and it also revealed maximum activity at the milky stage with salinity stress. This was associated with a smaller reduction in shoot fresh and dry weights, greater reduction in the leaf Na+ content and an increase in the K+ content, which ultimately increased the cytosolic K+/Na+ ratio. Chlorophyll a and b and carotenoid (total photosynthetic pigments) were also higher at the booting stage of salt-stressed plants treated with Si compared to other stages. Accordingly, Si application enhanced the salt tolerance of wheat and reduced the inhibitory effect of Na+ and oxidative stress damage as growth proceeded towards maturity, particularly at the booting stage. This shows that saline water can be used for wheat irrigation at the booting stage (much water is consumed) when good quality water is not available for supplemental irrigation. A field study is needed to confirm the greenhouse results.
ENTRY INTO MOTHERHOOD AMONG ADOLESCENT GIRLS IN TWO INFORMAL SETTLEMENTS IN NAIROBI, KENYA

Summary The contribution of adolescents' childbearing to total fertility rates in many sub-Saharan African countries is higher than in other parts of the world. In this paper, data collected from 897 female adolescents aged 15–19 years are analysed to investigate patterns and determinants of entry into motherhood in two informal settlements in Nairobi, Kenya, using Kaplan–Meier estimates and Cox regression models. About 15% of these adolescents have had a child. The findings show that marriage, being out of school and having negative models in peer, family and school contexts are associated with early childbearing among females aged 15–17 years. For adolescents aged 18–19 years, school attendance considerably delays entry into motherhood while marriage hastens its timing. Furthermore, older adolescents with high levels of social controls (parental monitoring or perceived peer orientation to or approval of prosocial behaviours) and individual controls (high religiosity and positive orientation to schooling) are likely to delay childbearing. Programmes aiming to reduce risky sexual behaviours that could lead to childbearing among adolescents should be introduced very early, and before the onset of sexual activity. Also, the findings underscore the need to identify and address the risky factors and reinforce the protective ones in order to improve sexual and reproductive health outcomes of adolescent girls in Nairobi slum settlements.
Analysis of Outcomes of the NRS 2002 in Patients Hospitalized in Nephrology Wards

Introduction: Malnutrition is a common problem among hospitalized patients. In chronic kidney disease, it affects up to 50% of the population. Undernourishment has an adverse effect on prognosis and prolongs convalescence. The aim of the study was to test the effectiveness of NRS (Nutrition Risk Screening) -2002 in the assessment of risk of malnutrition for patients hospitalized in nephrology wards. The aim was to develop clinical characteristics of malnourished patients and to assess the relationship between nutritional status and patient outcome. Methods: The analysis included 292 patients, consecutively admitted to nephrology wards. NRS-2002 was assessed in comparison to subjective global assessment. Associations with patient characteristics and outcome were evaluated. Results: Out of all the respondents, 119 patients (40%) suffered from malnutrition. The NRS-2002 showed a very strong relationship with Subjective Global Assessment (SGA) (p < 0.0001). Malnourished patients were older, were characterized by a significantly lower body mass index (BMI), and had a much longer hospitalization duration. In multiple regression analysis, the presence of malnutrition proved to be an independent predictor of the duration of hospital stay. CONCLUSIONS: Malnutrition is highly prevalent among patients hospitalized in nephrology wards, and it affects the length of hospitalization. Identification of malnourished patients and patients at serious risk of malnutrition progression allows the implementation of appropriate nutritional intervention.
Time‐resolved investigation of Cu(In,Ga)Se2 growth and Ga gradient formation during fast selenisation of metallic precursors

Ga segregation at the backside of Cu(In,Ga)Se2 solar cell absorbers is a commonly observed phenomenon for a large variety of sequential fabrication processes. Here, we investigate the correlation between Se incorporation, phase formation and Ga segregation during fast selenisation of Cu–In–Ga precursor films in elemental selenium vapour. Se incorporation and phase formation are analysed by real‐time synchrotron‐based X‐ray diffraction and fluorescence analysis. Correlations between phase formation and depth distributions are gained by interrupting the process at several points and by subsequent ex situ cross‐sectional electron microscopy and Raman spectroscopy. The presented results reveal that the main share of Se incorporation takes place within a few seconds during formation of In–Se at the top part of the film, accompanied by outdiffusion of In out of a ternary Cu–In–Ga phase. Surprisingly, CuInSe2 starts to form at the surface on top of the In–Se layer, leading to an intermediate double graded Cu depth distribution. The remaining Ga‐rich metal phase at the back is finally selenised by indiffusion of Se. On the basis of a proposed growth model, we discuss possible strategies and limitations for the avoidance of Ga segregation during fast selenisation of metallic precursors. Solar cells made from samples selenised with a total annealing time of 6.5 min reached conversion efficiencies of up to 14.2 % (total area, without anti‐reflective coating). The evolution of the Cu(In,Ga)Se2 diffraction signals reveals that the minimum process time for high‐quality Cu(In,Ga)Se2 absorbers is limited by cation ordering rather than Se incorporation. Copyright © 2014 John Wiley & Sons, Ltd.
Agents, Subsystems, and the Conservation of Information

Dividing the world into subsystems is an important component of the scientific method. The choice of subsystems, however, is not defined a priori. Typically, it is dictated by experimental capabilities, which may be different for different agents. Here, we propose a way to define subsystems in general physical theories, including theories beyond quantum and classical mechanics. Our construction associates every agent A with a subsystem SA, equipped with its set of states and its set of transformations. In quantum theory, this construction accommodates the notion of subsystems as factors of a tensor product, as well as the notion of subsystems associated with a subalgebra of operators. Classical systems can be interpreted as subsystems of quantum systems in different ways, by applying our construction to agents who have access to different sets of operations, including multiphase covariant channels and certain sets of free operations arising in the resource theory of quantum coherence. After illustrating the basic definitions, we restrict our attention to closed systems, that is, systems where all physical transformations act invertibly and where all states can be generated from a fixed initial state. For closed systems, we show that all the states of all subsystems admit a canonical purification. This result extends the purification principle to a broader setting, in which coherent superpositions can be interpreted as purifications of incoherent mixtures.
Efficient Approach to the Structure-Property Relationship of Woven and Braided Fabric-reinforced Composites up to Failure

In the author’s previous work, the woven and braided fabric-reinforced composites were analyzed using fully three-dimensional (3D) formulas of a micromechanics Bridging Model. Although explicit in expression, the 3D formulas require an iteration to determine the bridging elements involved at every load step when the analysis is out of elastic range. This is computationally less effective. In most cases, the woven and braided composites are reinforced with two-dimensional (2D) woven and braided preforms. For these composites, the 2D bridging model formulas may be more suitable. This has indeed been shown in the present paper. By comparing the predicted results of the 2D and the 3D bridging model formulas with the measured data for the stress-strain responses of a number of diamond and regular braided composites up to failure, it has been found that the 2D model is sufficiently accurate. Considering that no iteration is required, the 2D bridging model formulas are more efficient for the failure analysis and strength prediction of composites reinforced with 2D braided as well as woven fabrics.