Miracle-dz/UniFAR-FTUs huggingface dataset:
Generic Fibrational Induction

This paper provides an induction rule that can be used to prove properties of data structures whose types are inductive, i.e., are carriers of initial algebras of functors. Our results are semantic in nature and are inspired by Hermida and Jacobs’ elegant algebraic formulation of induction for polynomial data types. Our contribution is to derive, under slightly different assumptions, a sound induction rule that is generic over all inductive types, polynomial or not. Our induction rule is generic over the kinds of properties to be proved as well: like Hermida and Jacobs, we work in a general fibrational setting and so can accommodate very general notions of properties on inductive types rather than just those of a particular syntactic form. We establish the soundness of our generic induction rule by reducing induction to iteration. We then show how our generic induction rule can be instantiated to give induction rules for the data types of rose trees, definite hereditary sets, and hyperfunctions. The first of these lies outside the scope of Hermida and Jacobs’ work because it is not polynomial, and as far as we are aware, no induction rules have been known to exist for the second and third in a general fibrational framework. Our instantiation for hyperfunctions underscores the value of working in the general fibrational setting since this data type cannot be interpreted as a set.
The connections between horizontal cells and photoreceptors in the retina of the cat: Electron microscopy of Golgi preparations

Electron microscopy of Golgi preparations reveals that the dendritic terminals of horizontal cells in the cat's retina are connected only to cones. The axon terminals of these horizontal cells connect exclusively to rods. Dendritic and axonal terminals of horizontal cells penetrate the photoreceptor endings to become lateral elements of the invaginations. In addition this study suggests that each cone is in contact with more than one horizontal cell and that each rod connects to more than one axon terminal system. The horizontal cells of the cat are similar to those of the rhesus monkey in that the rod and cone connections are segregated to different portions of these cells.
AA-Dedupe: An Application-Aware Source Deduplication Approach for Cloud Backup Services in the Personal Computing Environment

The market for cloud backup services in the personal computing environment is growing due to large volumes of valuable personal and corporate data being stored on desktops, laptops and smart phones. Source deduplication has become a mainstay of cloud backup that saves network bandwidth and reduces storage space. However, there are two challenges facing deduplication for cloud backup service clients: (1) low deduplication efficiency due to a combination of the resource-intensive nature of deduplication and the limited system resources on the PC-based client site, and (2) low data transfer efficiency since post-deduplication data transfers from source to backup servers are typically very small but must often cross a WAN. In this paper, we present AA-Dedupe, an application-aware source deduplication scheme, to significantly reduce the computational overhead, increase the deduplication throughput and improve the data transfer efficiency. The AA-Dedupe approach is motivated by our key observations of the substantial differences among applications in data redundancy and deduplication characteristics, and thus is based on an application-aware index structure that effectively exploits this application awareness. Our experimental evaluations, based on an AA-Dedupe prototype implementation, show that our scheme can improve deduplication efficiency over the state-of-art source-deduplication methods by a factor of 2-7, resulting in shortened backup window, increased power-efficiency and reduced cost for cloud backup services.
Spintronics in cluster-assembled nanostructures

In the last years, the progressive miniaturization of magnetic storage devices has imposed the necessity to understand how the physical properties are modified with respect to the bulk when the dimensions are reduced at the nanometric scale. For this reason an accurate method of preparation and characterization of nanostructures is extremely important. This work focuses on the magnetic and transport properties of cluster-assembled nanostructures, namely cobalt nanoparticles embedded in copper matrices. Our setup allows us to independently control the mean cluster size, the concentration and the chemical composition. The cobalt cluster production is based on magnetron sputtering and gas phase aggregation. The performance of the source permits a wide range of cluster masses, from one to several thousand atoms. As a first step we studied the role of inter-particle interactions in the transport and magnetic properties, increasing the cobalt nanoparticle concentration (from 0.5% to 2.5% and 5%). Our results demonstrate the necessary precautions and constitute a solid basis for further studies of the spintronic properties of granular systems. Finally, in order to describe the intrinsic magnetic properties of cluster-assembled nanostructures, we prepared strongly diluted samples (_0.5%) for different cluster sizes from 1.9 nm to 5.5 nm. We found that the magnetic properties are size-dependent. Using a complete magnetic characterization, sensitive to the change in the effective magnetic anisotropy, we show that the magnetic anisotropy is dominated by the contributions of the surface or of the shape of the nanoparticles
Comparing inspection strategies for software requirement specifications

This paper reports on a laboratory experiment on the use of decomposition strategies in software requirements inspections. The experiment follows on from the work of (Porter et al., 1995) who compared the use of scenarios with ad hoc and checklist techniques, finding (among other things) that the scenario technique was superior. This experiment compares the scenario technique with inspection strategies which are self-set by the inspection team prior to the inspection but after they have seen the documents to be inspected. The specification used was a system developed by a software company for a client in the commercial sector. It was found that the commercial scenarios developed for the experiment were not superior to self-set strategies. This suggests that the benefits to be derived from scenarios are derived through the decomposition process and that experienced people may be able to derive strategies that are at least as good, if not better, than a provided set of scenarios. An advantage we noticed with the provided scenarios was the manner in which this technique could be used to focus the reviewers' attention on particular defect types. This could be used to advantage in industry. The overall findings of this experiment supports and extends the earlier research on inspections.
Livestock Pricing In The Northern Kenyan Rangelands

This paper uses detailed, transactions-level data and a structural-heteroskedasticity-in-mean model to identify the determinants of livestock producer prices for pastoralists in the drylands of northern Kenya. The empirical results confirm the importance of animal characteristics, periodic events that predictably shift local demand or supply, and especially rainfall on the prices pastoralists receive for animals. Price risk premia are consistently negative in these livestock markets. The imposition of quarantines has a sharp negative effect on expected producer prices in the pastoral areas, revealing a distributionally regressive approach to animal disease control in Kenya.
The Impact of SYNTAX Score of Non-Infarct-Related Artery on Long- Term Outcome among Patients with Acute ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Objective We investigated the impact of the severity of stenosis in a non-infarct-related artery (IRA) on the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods Three hundred one consecutive patients (age: 59.7 ± 13.2 years, 85.5% men) underwent primary PCI during 2009–2012. Receiver operating characteristic curve analysis found the optimal cutoff for non-IRA SYNTAX score (SS) to be 2.5. We divided the patients into two groups according to this cutoff value. Results By multivariable analysis, non-IRA SS (≥2.5) was an independent predictor of major adverse cardiac events (hazard ratio [HR]: 2.15, 95% confidence interval [CI]: 1.21–3.79, P = 0.008) and all-cause mortality (HR: 3.49, 95% CI: 1.13–10.8, P = 0.03). However, the prediction of cardiovascular mortality had only borderline significance (HR: 3.29, 95% CI: 0.90–12.08, P = 0.07). Conclusion STEMI patients treated with primary PCI and moderate to severe non-IRA stenosis (SS ≥2.5) have more subsequent cardiac events. Those populations should be treated with more aggressive preventive and medical management.
Top–Down Attentional Control in Parkinson's Disease: Salient Considerations

Cognitive dysfunction in Parkinson's disease (PD) has been hypothesized to reflect a failure of cortical control. In keeping with this hypothesis, some of the cognitive deficits in PD resemble those seen in patients with lesions in the lateral pFC, which has been associated with top–down attentional control. However, there is no direct evidence for a failure of top–down control mechanisms in PD. Here we fill this gap by demonstrating disproportionate control by bottom–up attention to dimensional salience during attentional set shifting. Patients needed significantly more trials to criterion than did controls when shifting to a low-salient dimension while, remarkably, needing significantly fewer trials to criterion than did controls when shifting to a high-salient dimension. Thus, attention was captured by bottom–up attention to salient information to a greater extent in patients than in controls. The results provide a striking reinterpretation of prior set-shifting data and provide the first direct evidence for a failure of top–down attentional control, resembling that seen after catecholamine depletion in the pFC.
Differential neuroprotective effects of carnosine, anserine, and N‐acetyl carnosine against permanent focal ischemia

Carnosine (β‐alanyl‐L‐histidine) has been shown to exhibit neuroprotection in rodent models of cerebral ischemia. In the present study, we further characterized the effects of carnosine treatment in a mouse model of permanent focal cerebral ischemia and compared them with its related peptides anserine and N‐acetylated carnosine. We also evaluated the efficacy of bestatin, a carnosinase inhibitor, in ameliorating ischemic brain damage. Permanent focal cerebral ischemia was induced by occlusion of the middle cerebral artery (pMCAO). Mice were subsequently randomly assigned to receive an intraperitoneal injection of vehicle (0.9% saline), carnosine, N‐acetyl carnosine, anserine, bestatin alone, or bestatin with carnosine. Infarct size was examined using 2,3,5‐triphenyltetrazolium chloride staining 1, 3, and 7 days following pMCAO, and neurological function was evaluated using an 18‐point‐based scale. Brain levels of carnosine were measured in treated mice using high‐performance liquid chromatography 1 day following pMCAO. We demonstrated that treatment with carnosine, but not its analogues, was able to significantly reduce infarct volume and improve neurological function compared with those in vehicle‐treated mice. These beneficial effects were maintained for 7 days post‐pMCAO. In contrast, compared with the vehicle‐treated group, bestatin‐treated mice displayed an increase in the severity of ischemic lesion, which was prevented by the addition of carnosine. These new data further characterize the neuroprotective effects of carnosine and suggest that carnosine may be an attractive candidate for testing as a stroke therapy. © 2008 Wiley‐Liss, Inc.
Molecular Epidemiology of Campylobacter jejuni Populations in Dairy Cattle, Wildlife, and the Environment in a Farmland Area

ABSTRACT We describe a cross-sectional study of the molecular epidemiology of Campylobacter jejuni in a dairy farmland environment, with the aim of elucidating the dynamics of horizontal transmission of C. jejuni genotypes among sources in the area. A collection of 327 C. jejuni isolates from cattle, wildlife, and environmental sources in a 100-km2 area of farmland in northwest England was characterized by multilocus sequence typing. A total of 91 sequence types and 18 clonal complexes were identified. Clonal complexes ST-21, ST-45, and ST-61, which have been frequently associated with human disease, were the most commonly recovered genotypes in this study. In addition, widely distributed genotypes as well as potentially host-associated genotypes have been identified, which suggests that both restricted and interconnecting pathways of transmission may be operating in the dairy farmland environment. In particular, the ST-61 complex and the ST-21 complex were significantly associated with cattle. In contrast, complex strains ST-45, ST-952, and ST-677 were isolated predominantly from wild birds, wild rabbits, and environmental water. A considerable number of novel sequence types have also been identified, which were unassigned to existing clonal complexes and were frequently isolated from wildlife and environmental sources. The segregated distribution of genotypes among samples from different sources suggests that their transmission to humans is perhaps via independent routes. Insight into the dynamics and interactions of C. jejuni populations between important animal reservoirs and their surrounding environment would improve the identification of sources of Campylobacter infection and the design of control strategies.
Toward Improving Digital Attribution Model Accuracy

The accuracy of an attribution model is limited by the assumptions of the model, and the quality and completeness of the data available to the model. Common digital attribution models on the market make a critical, yet hidden, assumption that ads only affect users by directly changing their propensity to convert. These models assume that ad exposure does not change user behavior in other ways, such as driving additional website visits, generating branded searches, or creating awareness and interest in the advertiser. In a previous paper [1], we described a Digital Advertising System Simulation (DASS) for modeling advertising and its impact on user behavior. In this paper, we use this simulation to demonstrate that current models fail to accurately capture the true number of incremental conversions generated by ads that impact user behavior, and introduce an Upstream DataDriven Attribution (UDDA) model to address this shortcoming. We also demonstrate that development beyond UDDA is still required to address a lack of data completeness, and situations that include highly targeting advertising.
V‐Notch Technique for Single‐Edge Notched Beam and Chevron Notch Methods

The technique of a V-shaped notch with very sharp root radius was used with the single-edge notched beam and chevron notch methods to evaluate fracture toughness of ceramics. These methods are improved techniques using a V-shaped diamond wheel. The single-edge precracked beam and chevron notch techniques were also used to compare with these methods. The material used is a gas-pressured Si3N4. The fracture toughness measured by these techniques showed quite small scatters and coincided with one another quite well, except for the usual chevron notch method.
Exercise as a treatment for depression

1. The participant will be able to recognize the benefits of exercise as a treatment for depression in their patients. 2. The participant will be able to understand the need to maintain or improve fitness levels in injured or immobile athletes in order to decrease the potential onset of depression. 3. The participant will be able to explain the basic exercise prescription that will help in the reduction of symptoms of depression. 4. The participant will be able to understand the physiologic and psychologic mechanisms through which exercise may reduce symptoms of depression.
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Aβ toxicity

Cells that have evolved to produce large quantities of secreted proteins to serve the integrated functions of complex multicellular organisms are equipped to compensate for protein misfolding. Hepatocytes and plasma cells have well developed chaperone and proteasome systems to ensure that secreted proteins transit the cell efficiently. The number of neurodegenerative disorders associated with protein misfolding suggests that neurons are particularly sensitive to the pathogenic effects of aggregates of misfolded molecules because those systems are less well developed in this lineage. Aggregates of the amyloidogenic (Aβ1–42) peptide play a major role in the pathogenesis of Alzheimer's disease (AD), although the precise mechanism is unclear. In genetic studies examining protein–protein interactions that could constitute native mechanisms of neuroprotection in vivo, overexpression of a WT human transthyretin (TTR) transgene was ameliorative in the APP23 transgenic murine model of human AD. Targeted silencing of the endogenous TTR gene accelerated the development of the neuropathologic phenotype. Intraneuronal TTR was seen in the brains of normal humans and mice and in AD patients and APP23 mice. The APP23 brains showed colocalization of extracellular TTR with Aβ in plaques. Using surface plasmon resonance we obtained in vitro evidence of direct protein–protein interaction between TTR and Aβ aggregates. These findings suggest that TTR is protective because of its capacity to bind toxic or pretoxic Aβ aggregates in both the intracellular and extracellular environment in a chaperone-like manner. The interaction may represent a unique normal host defense mechanism, enhancement of which could be therapeutically useful.
Bullying, Cyberbullying, and Suicide

Empirical studies and some high-profile anecdotal cases have demonstrated a link between suicidal ideation and experiences with bullying victimization or offending. The current study examines the extent to which a nontraditional form of peer aggression—cyberbullying—is also related to suicidal ideation among adolescents. In 2007, a random sample of 1,963 middle-schoolers from one of the largest school districts in the United States completed a survey of Internet use and experiences. Youth who experienced traditional bullying or cyberbullying, as either an offender or a victim, had more suicidal thoughts and were more likely to attempt suicide than those who had not experienced such forms of peer aggression. Also, victimization was more strongly related to suicidal thoughts and behaviors than offending. The findings provide further evidence that adolescent peer aggression must be taken seriously both at school and at home, and suggest that a suicide prevention and intervention component is essential within comprehensive bullying response programs implemented in schools.
Research of Human-simulated Intelligent Controller in Industrial Control

The author has discussed the principle of human-simulated intelligent controller (HSIC) and it’s application in industrial control. The improved HSIC compensates and consumes the system according to different conditions combined by error and error change rate. Because the parameter tuning of HSIC is completed in programmable logic controller, the control strategy of HSIC is simple than that of PID algorithm and the system response speed is more quickly. The author suggests that the parameters of HSIC should be optimized to decrease the complex degree of parameter tuning process and to reduce system overshoot dramatically.
Predictive Value of Aurora-A/STK15 Expression for Late Stage Epithelial Ovarian Cancer Patients Treated by Adjuvant Chemotherapy

Purpose: To investigate the expression and regulation of the centrosomal kinase Aurora-A/STK15 (AURKA) in epithelial ovarian cancers and to determine the prognostic and predictive value of this marker for patients with late stage epithelial ovarian cancer treated by distinct adjuvant chemotherapies. Experimental Design: Archival resection specimens of epithelial ovarian cancers (n = 115) and nonneoplastic ovaries (n = 28) were analyzed for AURKA mRNA and protein expression by microdissection and quantitative reverse transcriptase-PCR and immunohistochemistry. AURKA DNA copy numbers were measured by fluorescence in situ hybridization in 37 cases. Statistical evaluation was done with respect to clinicopathologic variables, disease-free survival, and overall survival. Results: AURKA mRNA expression was significantly elevated in cancers (P < 0.001) and correlated with AURKA protein expression (P = 0.0134). Overexpression of AURKA protein was detected in 68 of 107 (63.5%) cases and was linked with increased AURKA DNA copy numbers (P = 0.0141) and centromere 20 aneusomy (P = 0.0137). Moreover, AURKA overexpression was associated with improved overall survival in optimal debulked patients receiving taxol/carboplatin therapy (n = 43, P = 0.018). Finally, in an exploratory approach, patients receiving non–taxane-based therapy, AURKA overexpression was predictive for worse overall survival (n = 30, P = 0.049). Conclusions: AURKA overexpression is seen in the majority of late stage epithelial ovarian cancers, most likely due to increased AURKA DNA copy numbers and/or chromosome 20 aneusomy. Importantly, AURKA overexpression may differentially affect taxane and non–taxane-based adjuvant therapy responses. The study sheds new light on AURKA expression and regulation in epithelial cancers in vivo and specifically shows its value as a clinically relevant marker and as a potential therapeutic target per se.
SCCRO (DCUN1D1) Induces Extracellular Matrix Invasion by Activating Matrix Metalloproteinase 2

Purpose: Ectopic expression of squamous cell carcinoma–related oncogene (SCCRO or DCUN1D1) in NIH-3T3 cells induces invasion in vitro and produces highly invasive xenografts in nude mice with a propensity for regional lymphatical metastasis. The aim of this study was to identify the molecular mechanism underlying SCCRO-induced invasion and metastasis. Experimental Design: The molecular mechanism of SCCRO-mediated effects on matrix metalloproteinase-2 (MMP2) levels and activity were assessed using a combination of cell biological and molecular methods, including real-time PCR, reporter assay, RNA interference, and chromatin immunoprecipitation assay. Tumor specimens from primary upper aerodigestive tract carcinomas (n = 89) were examined for levels of SCCRO, MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA by real-time PCR. Results: Overexpression of SCCRO increases MMP2 levels and activity, which is required for SCCRO-induced invasion. Modified McKay assays reveal that SCCRO does not bind to the MMP2 promoter, suggesting that its transcriptional effects are indirect. Deletion or mutation of the activator protein-2 (AP2) and p53 binding element within the MMP2 promoter abrogates SCCRO-driven activation. Ectopic expression of SCCRO increases AP2 levels and promotes the binding of p53 to the MMP2 promoter. Consistent with these findings, SCCRO and MMP2 are coexpressed (P < 0.0001; r2 = 0.58; 95% confidence interval, 0.46-0.69) in primary (upper aerodigestive tract) carcinomas (n = 89), and this coexpression is associated with an increased prevalence of regional nodal metastasis (P = 0.04; relative risk, 1.53). Conclusions: SCCRO-induced invasion involves activation of MMP2 transcription in an AP2- and p53-dependent manner. SCCRO is a potential marker for metastatic progression in affected cancers.