Miracle-dz/UniFAR-FTUs huggingface dataset:
Labour of love: Female juvenile prostitution in the Netherlands

Summary Although the number of young prostitutes increases, little systematic research has been undertaken to gain more insight into the trafficking of these young women. The main object of the present study was to describe the processes (that is, grooming, incorporation, and maintenance) that underlie the trafficking of young women for prostitution. Police records of 16 adolescent prostitutes were analysed. Results show that these prostitutes were recruited by so-called ‘lover boys’ who applied various seduction techniques to make the vulnerable young women fall in love with them. In general, the young women were incorporated into prostitution by means of physical violence. To protect and secure their income and organization, the pimps used a wide range of power and control tactics, of which the use of physical violence can be considered the most effective.
Success of University Student Volunteers in Obtaining Consent for Reviewing Private Health Information for Emergency Research

ABSTRACT This study aimed to determine the success of university student volunteers in obtaining consent from parents to allow review of their child’s personal health information (PHI) for emergency research screening. This study also aimed to examine the variables associated with successful consent. This was a prospective cross-sectional study conducted at a pediatric emergency department (ED). University students, who functioned as delegates of the health information custodian, approached parents for consent. Of 2,506 parents, 1,852 (73.9%) provided consent to allow review of their child’s PHI for research screening. Variables associated with successful consent were high (≥12 months) versus low (<12 months) volunteer experience (OR = 2.0), research related (vs. unrelated) to the child’s chief complaint (OR = 2.0), child treated regularly by specialists at the study institution (OR = 1.7), and ED presentation mid-week vs. weekend (OR = 1.7) and morning vs. evening presentation (OR = 1.4). When approached by a university student volunteer, about 25% of parents declined to have their child’s PHI reviewed for research screening. This model of obtaining consent may put some emergency research at risk for selection bias. Variables that increase the odds of successful consent can be considered in program design to improve the effectiveness of this model.
YAP1 is essential for tumor growth and is a potential therapeutic target for EGFR-dependent lung adenocarcinomas

Epidermal growth factor receptor (EGFR) mutations are found in lung adenocarcinomas leading to tumor cells proliferation and survival. EGFR tyrosine kinase inhibitors (TKIs) that block EGFR activity are effective therapeutics for EGFR-mutant lung adenocarcinoma patients, but TKI-resistance inevitably occurs. The YES-associated protein (YAP1) transcription coactivator has been implicated as an oncogene and is amplified in human cancers and provides tumor cells strong proliferation and survival cues. This study investigated the roles of YAP1 in lung adenocarcinoma by exploring its regulation and functions mediated by EGFR signaling. In this study, we detected a correlation between YAP1 level and EGFR mutation status in lung adenocarcinoma tissues. Using lung adenocarcinoma cell lines, enhanced YAP1 expression and activity mediated by EGFR signaling was detected through enhanced protein stability. A SRC family protein, YES, was involved in EGFR-regulated YAP1 expression and this pathway was crucial for proliferation in EGFR-dependent cells. Small molecules that reduced YAP1 levels by mechanisms bypassing EGFR signaling were effective in reducing viability in EGFR-dependent cells including those with EGFR T790M, the major cause of TKI-resistance. These observations unveiled the significance of YAP1 in EGFR mutant lung adenocarcinomas and identified YAP1 as a promising therapeutic target for EGFR-dependent lung adenocarcinoma patients, including those with EGFR T790M-caused TKI resistance.
Extracellular matrix metalloproteinase inducer is expressed in the proximal tubular epithelial cells of the human kidney

Aim: Matrix metalloproteinases (MMP) affect matrix remodelling, and extracellular matrix metalloproteinase inducer (EMMPRIN) has been reported to increase the levels of several MMP. However, the expression of EMMPRIN in the human kidney and its regulatory mechanisms are not well known. In this study, we examined EMMPRIN expression in the human kidney with the biopsied specimens, cultured proximal tubular epithelial cells (PTEC) and human mesangial cells (HMC).
Deaf Jokes and Sign Language Humour

This paper describes the humor of Deaf communities, arguing that the humor is related primarily to the dominant visual experience of Deaf people, but also influenced by their knowledge of humor traditions in the hearing society at large. Sign language humor in America and Britain may be seen in the creation of new visual signs, the witty reanalysis of existing signs and in bilingual games in which English is manipulated within sign languages. The content of Deaf humor supports the in-group of community members who embrace their signing collective Deaf identity and denigrates out-group people, including deaf people who do not belong to the community and hearing people who are often seen as a threat to the community. Many of these jokes also make reference to sign language. We conclude that the visual nature of Deaf humor is one of its key characteristics and ask what else this can tell us about the Deaf cultural way of interacting with and presenting the world.
TV Viewing, Perceived Similarity, Coviewing, and Mental Well-Being Among African American, Latino, and White Children

Research among adults has demonstrated concurrent and prospective negative associations between TV viewing and mental health, yet little research has examined these associations among African American and Latino youth or examined the role of children’s involvement with TV and parental mediation of TV viewing via coviewing. The purpose of the present study is to examine associations between TV viewing, perceived similarity, and coviewing and mental well-being in African American, Latino, and White children. Results from Healthy Passages™, a study of 4,824 African American (30%), Latino (47%), and White (23%) fifth graders, indicated that TV viewing and perceived similarity were negatively associated with mental well-being among most groups of children, and coviewing was positively associated with mental well-being among Latinos. This study extends findings from adult research on media exposure and mental well-being into a diverse sample of fifth graders and illuminates the role of perceived similarity and coviewing.
Changes of Alpha1-Antitrypsin Levels in Allergen-induced Nasal Inflammation

Objectives Alpha1-antitrypsin (AAT) is the main inhibitor of human neutrophil elastase, and plays a role in counteracting the tissue damage caused by elastase in local inflammatory conditions. The study evaluated the involvement of AAT in nasal allergic inflammation. Methods Forty subjects with mono-sensitization to Dermatophagoides pteronyssinus (Dpt) were enrolled. Twenty allergic rhinitis patients frequently complained of nasal symptoms such as rhinorrhea, stuffiness, sneezing, and showed positive responses to the nasal provocation test (NPT) with Dpt (Group I). The other 20 asymptomatic patients showed sensitization to Dpt but negative NPT (Group II). The levels of AAT, eosinophil cationic protein (ECP), and Dpt-specific IgA antibodies were measured in the nasal lavage fluids (NLFs), collected at baseline, 10 minutes, 30 minutes, 3 hours, and 6 hours after the NPT. Nasal mucosa AAT expression was evaluated with immunohistochemical staining from Group I and Group II. Results At baseline, only the Dpt-specific IgA level was significantly increased in the NLFs of Group I compared with Group II, while ECP and AAT levels were not significantly different between two groups. After Dpt provocation, AAT, ECP, and Dpt-specific IgA levels were significantly increased in the NLFs of Group I during the early and late responses. The protein expression level of AAT was mostly found in the infiltrating inflammatory cells of the nasal mucosa, which was significantly increased in Group I compared to Group II. Conclusion The increment of AAT showed a close relationship with the activation of eosinophils induced by allergen-specific IgA in the NLFs of patients with allergic rhinitis after allergen stimulation. These findings implicate AAT in allergen-induced nasal inflammation.
On invariant measures

Given a measurable transformation on a measure space one can ask whether or not there is an equivalent measure that is invariant under the transformation. This problem is discussed very thoroughly in Halmos' Lectures on ergodic theory, pp. 81-90, 97. The first result along these lines is due to E. Hopf who obtained necessary and sufficient conditions for the existence of a finite invariant measure. The condition is that the whole space is "bounded," i.e. that the space is not a "copy" of a subset of strictly smaller measure. ("Copy" is defined below.) Recently Hajian and Kakutani (the paper is not yet published) showed that Hopf s condition is equivalent to the nonexistence of a set of nonzero measure having infinitely many disjoint images under the powers of the transformation. In [3] Halmos proved that there was a sigma-finite invariant measure if and only if the space was the union of a countable number of "bounded" sets. It was not known however whether or not every transformation had this property. Our example shows that there are transformations that admit no equivalent invariant measures.
A Sex-Specific MicroRNA-96/5-Hydroxytryptamine 1B Axis Influences Development of Pulmonary Hypertension.

RATIONALE Females are predisposed to pulmonary arterial hypertension (PAH); evidence suggests that serotonin, mutations in the bone morphogenetic protein receptor (BMPR) II gene, and estrogens influence development of PAH. The 5-hydroxytryptamine 1B receptor (5-HT1BR) mediates human pulmonary artery smooth muscle cell (hPASMC) proliferation. OBJECTIVES We aimed to determine whether selected microRNAs (miRNAs) expressed in PASMCs are influenced by sex, BMPR-II mutations, and estrogens, and contribute to PASMC proliferation in PAH. METHODS Expression levels of miRNAs targeting genes related to PAH, estrogen, and serotonin were determined by quantitative RT-PCR in hPASMCs and mouse PASMCs harboring a heterozygous mutation in BMPR-II (BMPR-II(R899X+/-) PASMCs). miRNA-96 targets 5-HT1BR and was selected for further investigation. miRNA target validation was confirmed by luciferase reporter assay. Precursor miRNA-96 was transfected into hPASMCs to examine effects on proliferation and 5-HT1BR expression. The effect of a miRNA-96 mimic on the development of hypoxic pulmonary hypertension in mice was also assessed. MEASUREMENTS AND MAIN RESULTS miRNA-96 expression was reduced in BMPR-II(R899X+/-) PASMCs from female mice and hPASMCs from female patients with PAH; this was associated with increased 5-HT1BR expression and serotonin-mediated proliferation. 5-HT1BR was validated as a target for miRNA-96. Transfection of precursor miRNA-96 into hPASMCs reduced 5-HT1BR expression and inhibited serotonin-induced proliferation. Restoration of miRNA-96 expression in pulmonary arteries in vivo via administration of an miRNA-96 mimic reduced the development of hypoxia-induced pulmonary hypertension in the mouse. CONCLUSIONS Increased 5-HT1BR expression may be a consequence of decreased miRNA-96 expression in female patient PASMCs, and this may contribute to the development of PAH.
Functional Analysis of the Rat I Sodium Channel inXenopus Oocytes

Voltage-gated sodium channels in the mammalian CNS initiate and propagate action potentials when excitatory inputs achieve threshold membrane depolarization. There are multiple sodium channel isoforms expressed in rat brain (types I, II, III, 6, and NaG). We have constructed a full-length cDNA clone encoding type I and compared the electrophysiological properties of type I (Rat1) and II (Rat2) channels in the absence and presence of the two accessory subunits β1 and β2. Injection intoXenopus oocytes of RNA encoding Rat1 resulted in functional sodium currents that were blocked by tetrodotoxin, with Kapp = 9.6 nm. Rat1 sodium channels had a slower time course of fast inactivation than Rat2. Coexpression of β1 accelerated inactivation of both Rat1 and Rat2, resulting in comparable inactivation kinetics. Rat1 recovered from fast inactivation more rapidly than Rat2, regardless of whether β1 or β2 was present. The voltage dependence of activation was similar for Rat1 and Rat2 without the β subunits, but it was more positive for Rat1 when β1 and β2 were coexpressed. The voltage dependence of inactivation was more positive for Rat1 than for Rat2, and coexpression with β1 and β2 accentuated that difference. Finally, sodium current amplitudes were reduced by 7–9% for both Rat1 and Rat2 channels when protein kinase A phosphorylation was induced. It has been suggested previously that Rat1 and Rat6 channels mediate transient and maintained sodium conductances, respectively, in Purkinje cells, and the electrophysiological properties of Rat1 currents are consistent with a role for this channel in mediating the rapidly inactivating, transient current.
Single-Session/Walk-In Therapy with Mexican-American Clients

Therapists working with minority populations frequently encounter clients who have a high probability of not returning after the first session. However, research indicates that a high percentage of clients who choose not to return are satisfied with these unplanned single sessions. Single sessions appear to be a good fit for minority populations. This article demonstrates the value of a single session perspective with two representative Mexican-American, multiproblem case examples. Research is discussed, basic assumptions in our model are highlighted, and we demonstrate how change is created when a meaningful shift in the client's perception occurs. It is suggested that therapists consider approaching clients from a stance of, “Each case has the potential of being a single session,” to create an expectancy for change.
A longitudinal analysis of citizens' attitudes about police

Purpose – Prior research has established the importance of citizens' perceptions of procedural justice in determining their assessments of and satisfaction with police. The present study seeks to contribute to this literature in three ways. First, it aims to test for a link between perceived procedural justice and performance‐based assessments of police officers' ability to control serious crime. Second, it aims to test this link using longitudinal data and controls for existing attitudes to ensure directional validity of the results. Finally, it aims to advance the literature by extending the study of personal experiences and process‐based judgments to non‐urban areas.Design/methodology/approach – The data were gathered using a panel design consisting of two surveys administered three years apart. The data are analyzed using ordinary least squares regression.Findings – The results support the hypothesis that citizens' perceived procedural justice during their personal contact with officers significantly .
Approximate information sources and perceptual variables in interceptive timing.

D. N. Lee suggested that people time actions that involve the interception of a moving target using the information provided by the optic variable tau (τ). Using τ to time interceptions involves approximations that lead to errors in timing not reflected in human performance. Thus, it is to be expected that other perceptual information is used instead of or in addition to τ. Two additional variables are theoretically important: the instantaneous angle between the target and interception point and the target's rate of change of direction. Data suggest that these 2 variables are used in addition to τ. The data also demonstrate that when only the moving target is visible subjects do not rely on τ information alone to time interceptions
Who is a Good Early Childhood Educator? A Critical Study of Differences within a Universal Professional Identity in Early Childhood Education Preparation Programs

This article reports on a qualitative research project that examined ways in which pedagogical discourses within an early childhood education college preparation program construct a universal identity of the “good early childhood educator. ” Drawing upon theoretical explanations of the concept of difference in professional identification, a discursive analysis of the research participants' views indicates that the good early childhood educator is, on the whole, perceived as possessing a single, normative identity that is decontextualized from social relations. Cultural differences are simultaneously recognized, managed and denied through several discursive moves. If, however, diversity in the early childhood education (ECE) workforce is desired, then recognition of the value of difference needs to be integral and central to the construction of a professional early childhood educator identity, so that new social relations in the classroom can be structured.
Association of Subjective and Interpretive Drowsiness with Facial Dynamic Changes in Simulator Driving.

BACKGROUND Major injuries and death in accidents have roots in drowsiness. Sleepiness is a main result of insufficient sleep. It is vital to explore drowsiness and its level. There are various sorts of methods in the forms of subjective and objective approaches. The goal of this study was to detect the association of subjective and interpretive drowsiness with facial dynamic changes. METHODS This experimental study was conducted in the Virtual Reality Lab, in Khaje-Nasir Toosi University of Technology, Tehran Iran on 40 drivers in 2015. Facial dynamic changes (eyes, mouth and eyebrows), Karolinska Sleepiness Scale (KSS) and Observer Rating of Drowsiness (ORD) were applied. The neural network and Viola-Jones were utilized for facial characteristics detection. Statistical analyses were conducted using SPSS version 21. RESULTS Thirty-four drivers got drowsy during the test. They were selected randomly among suburban drivers at the age in a range of 26 to 60 yr old. Descriptive statistics of the dynamic changes in eyebrows, mouth and eyes showed that these features were of meaningful changes with respect to the level of drowsiness during driving. A relationship between the dynamic changes of facial features and ORD was recognized. Moreover, there was a significant relationship between facial expression and drowsiness (P<0.05). CONCLUSIONS Results of KSS and ORD illustrated that there were dynamic changes in eyes and mouth and eyebrow parameters while driver felt sleepy. This research is helpful in a way that specific changes in elements of face could be effective to provide tools to predict drowsiness.
Exploring the atheist personality: well-being, awe, and magical thinking in atheists, Buddhists, and Christians

Atheists are America’s least trusted group, and stereotypes about them abound: Atheists are non-conformist, sceptical, cynical, and joyless, rarely experiencing awe. Atheists (N = 42) were recruited from the American atheist website and compared to Christians (N = 22) and Buddhists (N = 18). Groups were highly similar in their reported well-being, empathy, and other personality scales, but differed strongly on scales assessing Spirituality and Magical Ideation, where atheists rejected the concepts of spirituality and magical beliefs. Responding to the question, “Have you ever felt wonderment or felt as if you were part of something greater than yourself? ,” 71% said “yes,” citing Nature (54%), Science, (30%), Music/Art (12%), and Human cooperation (8%). Respondents explained their lack of belief as deriving from a preference for logic and rationality, suggesting an intellectual component to atheism. Findings thus support the stereotype of atheists as logical, sceptical, and non-conformist, but not as cynical and joyless.
The expressivity of universal timed CCP: undecidability of Monadic FLTL and closure operators for security

The timed concurrent constraint programing model (tcc) is a declarative framework, closely related to First-Order Linear Temporal Logic (FLTL), for modeling reactive systems. The universal tcc formalism (utcc) is an extension of tcc with the ability to express mobility. Here mobility is understood as communication of private names as typically done for mobile systems and security protocols. This paper is devoted to the study of 1) the expressiveness of utcc and 2) its semantic foundations. As applications of this study, we also state 3) a noteworthy decidability result for the wellestablished framework of FLTL and 4) bring new semantic insights into the modeling of security protocols. More precisely, we show that in contrast to tcc, utcc is Turingpowerful by encoding Minsky machines. The encoding uses a monadic constraint system allowing us to prove a new result for a fragment of FLTL: The undecidability of the validity problem for monadic FLTL without equality and function symbols. This result refutes a decidability conjecture for FLTL from a previous paper. It also justifies the restriction imposed in previous decidability results on the quantification of flexible-variables. We shall also show that as in tcc, utcc processes can be semantically represented as partial closure operators. The representation is fully abstract wrt the input-output behavior of processes for a meaningful fragment of the utcc. This shows that mobility can be captured as closure operators over an underlying constraint system. As an application we identify a language for security protocols that can be represented as closure operators over a cryptographic constraint system.
Beneficence in psycho-social research and the role of containment

Within the context of research ethics beneficence consistently receives less attention than non-maleficence and research ‘benefits’ are predominantly understood in tangible, intentional terms. Scanter attention has been given to the more subtle aspects of the research process that elicit less tangible, and often unexpected, benefits for research participants. Drawing on a study conducted with social workers in two childcare social work settings, this article outlines how psycho-social approaches to research – and specifically the concept of containment – can provide fruitful theoretical and conceptual frameworks for the development of more complex understandings of beneficence in the research process. The article concludes by proposing that there is scope to enhance the experience and quality of research if, from the outset, attention to containment is embedded within the research process. Realizing ‘containing’ research involves firstly, recognizing the capacity of researchers to retain an observational stance of ‘negative capability’ that attends to research processes and secondly, understanding the importance of social researchers being contained through appropriate support systems that help to manage the anxiety inherent in social work research contexts specifically, and human relations research, more broadly.