Miracle-dz/UniFAR-FTUs huggingface dataset:
Human infancy and parenting in global perspective: specificity

We address three long-standing fundamental questions about early human development and parental caregiving within a specificity framework using data from 796 infant–mother dyads from 11 societies worldwide. Adopting a cross-society view opens a vista on universal biological origins of, and contextual influences on, infant behaviours and parenting practices. We asked: how do infant behaviours and parenting practices vary across societies? How do infant behaviours relate to other infant behaviours, and how do parent practices relate to other parent practices? Are infant behaviours and parent practices related to one another? Behaviours of firstborn five-month infants and parenting practices of their mothers were microanalysed from videorecords of extensive naturally occurring interactions in the home. In accord with behavioural specificity, biological expectations and cultural influences, we find that infants and mothers from diverse societies exhibit mean-level society differences in their behaviours and practices; domains of infant behaviours generally do not cohere, nor do domains of maternal practices; and only specific infant behaviours and mother practices correspond. Few relations were moderated by society.
The importance of model horizontal resolution for improved estimation of Snow Water Equivalent in a mountainous region of Western Canada

Accurate estimation of snow water equivalent (SWE) over high mountainous regions is essential to 30 support water resource management. Due to the sparse distribution of in situ observations, models have been used to estimate SWE. However, the influence of horizontal resolution on the accuracy of simulations remains poorly understood. This study evaluates the potential of the Weather Research and Forecasting (WRF) model at horizontal resolutions of 9, 3 and 1 km to estimate the daily values of SWE over the mountainous South Saskatchewan River Basin (SSRB) in Western Canada, for a representative 35 water year, 2017-18. Results show an accumulation period from October 2017 to the annual peak in April 2018, followed by a melting period to the end of water year. All WRF simulations tend to underestimate annual SWE, with largest biases (up to 58 kg/m 2 , i.e. relatively 24%) at higher elevations and coarser horizontal resolution. The two higher-resolution simulations capture the magnitude (and timing) of peak SWE very accurately, with only a 3 to 6% low bias for 1 km and 3 km simulations, respectively. This 40 demonstrates that a 3 km resolution may be appropriate for estimating SWE accumulation across the region. A relationship is identified between model elevation bias and SWE biases, suggesting that the smoothing of topographic features at lower horizontal resolution leads to lower grid cell elevations, warmer temperatures, and lower SWE. Overall, high resolution WRF simulations can provide reliable SWE values as an accurate input for hydrologic modeling over a sparsely monitored mountainous catchment.
Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

The articular surface plays an essential role in load transfer across the joint, and conditions that produce increased load transfer or altered patterns of load distribution accelerate the development of osteoarthritis (OA). Current knowledge segregates the risk factors into two fundamental mechanisms related to the adverse effects of “abnormal” loading on normal cartilage or “normal” loading on abnormal cartilage. Although chondrocytes can modulate their functional state in response to loading, their capacity to repair and modify the surrounding extracellular matrix is limited in comparison to skeletal cells in bone. This differential adaptive capacity underlies the more rapid appearance of detectable skeletal changes, especially after acute injuries that alter joint mechanics. The imbalance in the adaptation of the cartilage and bone disrupts the physiological relationship between these tissues and further contributes to OA pathology. This review focuses on the specific articular cartilage and skeletal features of OA and the putative mechanisms involved in their pathogenesis.
Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

Significance Glioblastoma is an incurable brain tumor. It is characterized by intratumoral phenotypic and genetic heterogeneity, but the functional significance of this heterogeneity is unclear. We devised an integrated functional and genomic strategy to obtain single cell-derived tumor clones directly from patient tumors to identify mechanisms of aggressive clone behavior and drug resistance. Genomic analysis of single clones identified genes associated with clonal phenotypes. We predict that integration of functional and genomic analysis at a clonal level will be essential for understanding evolution and therapeutic resistance of human cancer, and will lead to the discovery of novel driver mechanisms and clone-specific cancer treatment. Glioblastoma (GBM) is a cancer comprised of morphologically, genetically, and phenotypically diverse cells. However, an understanding of the functional significance of intratumoral heterogeneity is lacking. We devised a method to isolate and functionally profile tumorigenic clones from patient glioblastoma samples. Individual clones demonstrated unique proliferation and differentiation abilities. Importantly, naïve patient tumors included clones that were temozolomide resistant, indicating that resistance to conventional GBM therapy can preexist in untreated tumors at a clonal level. Further, candidate therapies for resistant clones were detected with clone-specific drug screening. Genomic analyses revealed genes and pathways that associate with specific functional behavior of single clones. Our results suggest that functional clonal profiling used to identify tumorigenic and drug-resistant tumor clones will lead to the discovery of new GBM clone-specific treatment strategies.
Active Flow Control on a Square-Back Road Vehicle

The fabulous results of convolution neural networks in image-related tasks, attracted attention of text mining, sentiment analysis and other text analysis researchers. It is however difﬁcult to ﬁnd enough data for feeding such networks, optimize their parameters, and make the right design choices when constructing network architectures. In this paper we present the creation steps of two big datasets of song emotions. We also explore usage of convolution and max-pooling neural layers on song lyrics, product and movie review text datasets. Three variants of a simple and ﬂexible neural network architecture are also compared. Our intention was to spot any important patterns that can serve as guidelines for parameter optimization of similar models. We also wanted to identify architecture design choices which lead to high performing sentiment analysis models. To this end, we conducted a series of experiments with neural architectures of various conﬁgurations. Our results indicate that parallel convolutions of ﬁlter lengths up to three are usually enough for capturing relevant text features. Also, max-pooling region size should be adapted to the length of text documents for producing the best feature maps. Top results we got are obtained with feature maps of lengths 6 to 18. An improvement on future neural network models for sentiment analysis, could be generating sentiment polarity prediction of documents using aggregation of predictions on smaller excerpt of the entire text.
Formin 2 regulates the stabilization of filopodial tip adhesions in growth cones and affects neuronal outgrowth and pathfinding in vivo

Growth cone filopodia are actin-based mechanosensory structures that are essential for chemoreception and the generation of contractile forces necessary for directional motility. However, little is known about the influence of filopodial actin structures on substrate adhesion and filopodial contractility. Formin 2 (Fmn2) localizes along filopodial actin bundles and its depletion does not affect filopodia initiation or elongation. However, Fmn2 activity is required for filopodial tip adhesion maturation and the ability of filopodia to generate traction forces. Dysregulation of filopodia in Fmn2-depleted neurons leads to compromised growth cone motility. Additionally, in mouse fibroblasts, Fmn2 regulates ventral stress fiber assembly and affects the stability of focal adhesions. In the developing chick spinal cord, Fmn2 activity is required cell-autonomously for the outgrowth and pathfinding of spinal commissural neurons. Our results reveal an unanticipated function for Fmn2 in neural development. Fmn2 regulates structurally diverse bundled actin structures, parallel filopodial bundles in growth cones and anti-parallel stress fibers in fibroblasts, in turn modulating the stability of substrate adhesions. We propose Fmn2 as a mediator of actin bundle integrity, enabling efficient force transmission to the adhesion sites. Highlighted article: Formin 2 regulates filopodial dynamics required for efficient translocation of neuronal growth cones, while depletion of formin 2 in vivo results in aberrant axonal tracts in the spinal cord.
dur-Transcriptional regulators transforming growth factor-β1 and estrogen-related receptor-α identified as putative mediators of calf rumen epithelial tissue development and function during weaning 1

Molecular mechanisms regulating rumen epithelial development remain largely unknown. To identify gene networks and regulatory factors controlling rumen development, Holstein bull calves (n = 18) were fed milk replacer only (MRO) until 42 d of age. Three calves each were euthanized at 14 and 42 d of age for tissue collection to represent preweaning, and the remaining calves were provided diets of either milk replacer + orchard grass hay (MH; n = 6) to initiate weaning without development of rumen papillae, or milk replacer + calf starter (MG; n = 6) to initiate weaning and development of rumen papillae. At 56 and 70 d of age, 3 calves from the MH and MG groups were euthanized for collection of rumen epithelium. Total RNA and protein were extracted for microarray analysis and to validate detected changes in selected protein expression, respectively. As expected, calves fed MRO had no rumen papillae and development of papillae was greater in MG versus MH calves. Differentially expressed genes between the MRO diet at d 42 (preweaning) versus the MG or MH diets at d 56 (during weaning) were identified using permutation analysis of differential expression. Expression of 345 and 519 transcripts was uniquely responsive to MG and MH feeding, respectively. Ingenuity Pathway Analysis (Qiagen, Redwood City, CA) indicated that the top-ranked biological function affected by the MG diet was the cell cycle, and TFGB1, FBOX01, and PPARA were identified as key transcriptional regulators of genes responsive to the MG diet and associated with development of rumen papillae. Increased expressions of TGFB1 mRNA and protein in response to the MG diet were confirmed by subsequent analyses. The top-ranking biological function affected by the MH diet was energy production. Receptors for IGF-1 and insulin, ESRRA, and PPARD were identified by ingenuity pathway analysis as transcriptional regulators of genes responsive to the MH diet. Further analysis of TGFB1 and ESRRA mRNA expression in rumen epithelium obtained from a separate ontogenic study of Holstein calves (n = 26) euthanized every 7 d from birth to 42 d of age showed increases in transcript expression with advancing age, supporting their roles in mediating rumen epithelial development and function during weaning. Additional evaluation of gene expression in the rumen epithelium of adult cows ruminally infused with butyrate also suggested that observed changes in ESRRA mRNA expression in developing calf rumen may be mediated by increased butyrate concentration. Our results identify TGFB1 and ESRRA as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
Outcome of axillary nerve injuries treated with nerve grafts

This study evaluates the outcome of axillary nerve injuries treated with nerve grafting. Thirty-six patients were retrospectively reviewed after a mean of 53 months (minimum 12 months). The mean interval from injury to surgery was 6.5 months. Recovery of deltoid function was assessed by the power of both abduction and retropulsion, the deltoid bulk and extension lag. The deltoid bulk was almost symmetrical in nine of 34 cases, good in 22 and wasted in three. Grade M4 or M5* was achieved in 30 of 35 for abduction and in 32 of 35 for retropulsion. There was an extension lag in four patients. Deltoid bulk continued to improve with a longer follow-up following surgery. Nerve grafting to the axillary nerve is a reliable method of regaining deltoid function when the lesion is distal to its origin from the posterior cord.
Nutrition Journal Effect of a Natural Extract of Chicken Combs with a High Content of Hyaluronic Acid (hyal-joint ® ) on Pain Relief and Quality of Life in Subjects with Knee Osteoarthritis: a Pilot Randomized Double-blind Placebo-controlled Trial

Background: Intra-articular hyaluronic acid represents a substantive addition to the therapeutic armamentarium in knee osteoarthritis. We examined the effect of dietary supplementation with a natural extract of chicken combs with a high content of hyaluronic acid (60%) (Hyal-Joint ®) (active test product, AP) on pain and quality of life in subjects with osteoarthritis of the knee.
Comorbidities of chronic obstructive pulmonary disease

Purpose of review Defining the nature of the association between chronic obstructive pulmonary disease (COPD) and other chronic conditions is of primary importance to improve the health status of COPD patients through the optimal care of comorbidities. We aimed at providing a reasoned guide to understand, recognize and treat comorbidity of COPD with the perspective of shifting from comorbidity to multimorbidity. Recent findings Select comorbidities, such as atherosclerotic disease, depression, chronic kidney disease, cognitive impairment, obstructive sleep apnea syndrome, lung cancer, osteoporosis, diabetes, heart failure, sarcopenia, aortic aneurysm, arrhythmias and pulmonary embolism are highly prevalent among older COPD patients. Several concerns may affect the management of older COPD patients with comorbidity (e.g. the use of &bgr;-blockers in patients with COPD and cardiovascular diseases or concerns about the cardiovascular safety of inhaled COPD drugs). Summary Evidence suggests that systemic inflammation may be the link between COPD and comorbidities, but this issue is still debated. Whatever the mechanism underlying comorbidities in COPD may be, it has an important clinical, prognostic and therapeutic impact. Nevertheless, clinical practice guidelines do not take into account comorbidities in their recommendations. Additionally, clinical trials investigating COPD treatment in the context of multimorbidity and considering geriatric outcomes are also distinctly lacking.
The soluble mannose receptor (sMR) is elevated in alcoholic liver disease and associated with disease severity, portal hypertension, and mortality in cirrhosis patients

Background and aims Hepatic macrophages (Kupffer cells) are involved in the immunopathology of alcoholic liver disease (ALD). The mannose receptor (MR, CD206), expressed primarily by macrophages, mediates endocytosis, antigen presentation and T-cell activation. A soluble form, sMR, has recently been identified in humans. We aimed to study plasma sMR levels and its correlation with disease severity and survival in ALD patients. Methods We included 50 patients with alcoholic hepatitis (AH), 68 alcoholic cirrhosis (AC) patients (Child-Pugh A (23), B (24), C (21)), and 21 healthy controls (HC). Liver status was described by the Glasgow Alcoholic Hepatitis Score (GAHS), Child-Pugh (CP) and MELD-scores, and in AC patients the hepatic venous pressure gradient (HVPG) was measured by liver vein catheterisation. We used Kaplan-Meier statistics for short-term survival (84-days) in AH patients and long-term (4 years) in AC patients. We measured plasma sMR by ELISA. Results Median sMR concentrations were significantly elevated in AH 1.32(IQR:0.69) and AC 0.46(0.5) compared to HC 0.2(0.06) mg/L; p<0.001 and increased in a stepwise manner with the CP-score (p<0.001). In AC sMR predicted portal hypertension (HVPG ≥10 mmHg) with an area under the Receiver Operator Characteristics curve of 0.86 and a high sMR cut-off (>0.43 mg/l) was associated with increased mortality (p = 0.005). Conclusion The soluble mannose receptor is elevated in alcoholic liver disease, especially in patients with AH. Its blood level predicts portal hypertension and long-term mortality in AC patients.
Practice of Cardiac Auscultation: Clinical perspectives and its implications on computer aided diagnosis

Study of the disease demographics in human population indicates that cardiac ailments are the primary cause of premature death, and a need for emergent technologies is felt to address the rising trend. However, development of automated heart sound analysis system and its usage at the grassroot levels for cardiac pre-screening have been hindered by the lack proper understanding of the intrinsic characteristics of cardiac auscultation. In this article we present an investigatory report based on a nationwide survey conducted on the practice of cardiac auscultation for determination of its effectiveness in diagnosis. The aims are to achieve better validation of heart sound acquisition methods and use the clinical feedback from cardiologists for improvements in the classification of the cardiac abnormalities. Results obtained from six different classifiers used in the study are illustrated, which show a remarkable specificity using an improvised classification hierarchy, derived based on clinical recommendations. The study addresses the needs for better understanding of the relevancy of heart sound signal parameters, recording transducers, recording location and the inherent complexity associated in interpretation of heart sounds, specially in noisy environments of out-patient departments and primary healthcare centers. Further, the inter-relationship between heart sound and other advance medical imaging modalities, and the need for more focused training in cardiac auscultation among the medical and paramedical staff is investigated.
Development of the Just Culture Assessment Tool: Measuring the Perceptions of Health-Care Professionals in Hospitals

Objectives Given the growing support for establishing a just patient safety culture in health-care settings, a valid tool is needed to assess and improve just patient safety culture. The purpose of this study was to develop a measure of individual perceptions of just culture for a hospital setting. Methods The 27-item survey was administered to 998 members of a health-care staff in a pediatric research hospital as part of the hospital’s ongoing patient safety culture assessment process. Subscales included balancing a blame-free approach with accountability, feedback and communication, openness of communication, quality of the event reporting process, continuous improvement, and trust. The final sample of 404 participants (40% response rate) included nurses, physicians, pharmacists, and other hospital staff members involved in patient care. Confirmatory factor analysis was used to test the internal structure of the measure and reliability analyses were conducted on the subscales. Results Moderate support for the factor structure was established with confirmatory factor analysis. After modifications were made to improve statistical fit, the final version of the measure included 6 subscales loading onto one higher-order dimension. Additionally, Cronbach &agr; reliability scores for the subscales were positive, with each dimension being above 0.7 with the exception of one. Conclusions The instrument designed and tested in this study demonstrated adequate structure and reliability. Given the uniqueness of the current sample, further verification of the JCAT is needed from hospitals that serve broader populations. A validated tool could also be used to evaluate the relation between just culture and patient safety outcomes.
Semantic Fusion Augmentation and Semantic Boundary Detection: A Novel Approach to Multi-Target Video Moment Retrieval

Given an untrimmed video and a natural language query, video moment retrieval (VMR) aims to retrieve video moments described by the query. However, most existing VMR methods assume a one-to-one mapping between the input query and the target video moment (single-target VMR), disregarding the possibility that a video may contain multiple target moments that match the query description (multi-target VMR). Previous methods tackle multi-target VMR by incorporating false negative moments with the original target moment for multi-target training. However, existing methods cannot properly work when no false negative moments exist in the video, or when the identified false negative moments are noisy but are still being utilized as pseudo-labels. In this paper, we propose to tackle multi-target VMR by S emantic F usion A ugmentation and Semantic B oundary D etection ( SFABD ). Specifically, we use feature-level augmentation to generate augmented target moments, along with an intra-video contrastive loss to ensure feature consistency. Meanwhile, we perform semantic boundary detection to adaptively remove all false negatives from the negative set of contrastive loss to avoid semantic confusion. Extensive experiments conducted on Charades-STA, Activ-ityNet Captions, and QVHighlights show that our method achieves state-of-the-art performance on multi-target metrics and single-target metrics. The source code is available at https://github.com/basiclab/SFABD.
The Dynamics of Interest Representation at the U.S. Supreme Court

How do organized interests respond to their opponents’ advocacy activities in a policy venue? Utilizing data on amicus curiae filings at the U.S. Supreme Court, the author estimates vector error correction and vector autoregression models that allow him test whether interests respond, in a dynamic sense, to the efforts of the “other side. ” The author capitalizes on the temporal sequencing of variation in advocacy activity to gain leverage on the causal connection between the behaviors of opposing sets of interests and provides a richer portrait of the dynamics of interest representation in a policy venue. The results reveal that organized interests respond positively to the advocacy activities of their opponents by exhibiting both short-term counteraction and long-term countermobilization, implying that over the long run, interest representation at the Court is responsive and perhaps balanced.