Miracle-dz/UniFAR-FTUs huggingface dataset:
HER2 Testing in Gastric and Gastroesophageal Junction Cancers: A New Therapeutic Target and Diagnostic Challenge

Adenocarcinomas of the stomach and gastroesophageal junction represent a major cause of cancer morbidity and mortality world wide. Complete surgical resection is the mainstay of treatment for nonmetastatic disease; however, many patients are not diagnosed until their disease is either locally advanced or metastatic and therefore unresectable. Clearly, there is an unmet clinical need for new therapeutic strategies, treatment options, and novel therapeutic targets. In a recent trial (Trastuzumab for GAstric cancer), patients assigned to the trastuzumab treatment protocol showed an improved overall survival over those not receiving treatment. Trastuzumab has recently been approved for treatment of advanced gastric and gastroesophageal junction cancers. Pathologists and diagnostic laboratories must be prepared for this new category of specimens requiring human epidermal growth factor receptor 2 testing, and have an awareness of the interpretive differences between breast and gastric cancers.
High-Speed High-Output Solid-Rotor Induction-Motor Technology for Gas Compression

This paper investigates the suitability of solid-rotor induction-motor technology for a natural-gas-compression application with a high power output. To this end, a new solid-rotor design for an 8-MW 6.6-kV 12 000-min-1 motor without any copper parts in the rotor was developed, and the motor performance was tested. In this paper, solid-rotor material selection, rotor slitting, and the end effects of the purely solid rotor are discussed. A frequency-dependent end-effect correction factor is introduced, and a method for the rotor-end-leakage correction is presented. The performance of the proposed end-effect correction factor is verified by comparing the calculated torque and power factor with the measured values.
Dependence of Tensile Bending Strength of Rammed Earth on Used Clay Composition and Amount of Mixture Water

Clay is a traditional construction material which has got to background with introduction of modern materials to building practice. There is not proper material available for clay constructions design due to a lack of proper examination of its mechanical properties. This article focuses on tensile bending strength of rammed earth. The mechanical properties depend on the amount of mixture water and on the amount and type of clay minerals. The clay minerals play role of the binder similarly like a cement in concrete. This paper is focused on the tensile bending strength and its dependence on the composition and quantity of clay mineral and its dependence on the amount of mixture water. Five earth mixtures were tested. Mechanical properties were examined on small test bodies made of these mixtures. The mechanical properties of the five mixtures are compared at the end of the paper.
ICU Physician-Based Determinants of Life-Sustaining Therapy During Nights and Weekends: French Multicenter Study From the Outcomerea Research Group*

Objective: Patient- and organization-related factors are the most common influences affecting the ICU decision-making process. Few studies have investigated ICU physician-related factors and life-sustaining treatment use during nights and weekends, when staffing ratios are low. Here, we described patients admitted during nights/weekends and looked for physician-related determinants of life-sustaining treatment use in these patients after adjustment for patient- and center-related factors. Design: Multicenter observational cohort study of admission procedures during nights/weekends shifts. Subjects: ICU physicians working nights/weekends in 6 French ICUs. Interventions: None. Measurements and Main Results: Patient characteristics and intensity of care were extracted from the prospective Outcomerea database. Physician characteristics were age, gender, religion and religiosity, ICU experience, specialty, being a permanent ICU staff member, degree in ethics, and degree in intensive care. We used hierarchical mixed models to adjust on center, physician random effects, and admission patient characteristics. Of 156 physicians contacted, 119 (77%) participated. Patients admitted during nights/weekends were younger and had fewer comorbidities and lower treatment intensity during the shift. ICU physicians who are younger than 35 years used more renal replacement therapy (odds ratio, 1.04; 95% CI, 1–1.07; p = 0.04), invasive mechanical ventilation (odds ratio, 1.09; 95% CI, 1.1–1.19; p = 0.04), and vasopressors (odds ratio, 1.16; 95% CI, 1.09–1.23; p < 0.0001). Internal or emergency medicine as the primary specialty was associated with invasive mechanical ventilation (odds ratio, 1.14; 95% CI, 1.04–1.24; p = 0.004) and vasopressor use (odds ratio, 1.09; 95% CI, 1.02–1.17; p = 0.01). Noninvasive ventilation was used less often by physicians with more than 10 years of night/weekend shifts and more often by those with religious beliefs (odds ratio, 1.05; 95% CI, 1.01–1.08; p = 0.008). Conclusions: Patients admitted during nights/weekends were younger and had fewer comorbidities. Age, specialty, ICU experience, and religious beliefs of the physicians were significantly associated life-sustaining treatments used.
Smoking and smoking cessation in relation to mortality in women.

CONTEXT Smoking is associated with an increased risk of total and cause-specific death, but the rate of mortality risk reduction after quitting compared with continuing to smoke is uncertain. There is inadequate or insufficient evidence to infer the presence or absence of a causal relationship between smoking and ovarian cancer and colorectal cancer. OBJECTIVE To assess the relationship between cigarette smoking and smoking cessation on total and cause-specific mortality in women. DESIGN, SETTING, AND PARTICIPANTS Prospective observational study of 104,519 female participants in the Nurses' Health Study with follow-up from 1980 to 2004. MAIN OUTCOME MEASURE Hazard ratios (HRs) for total mortality, further categorized into vascular and respiratory diseases, lung cancer, other cancers, and other causes. RESULTS A total of 12,483 deaths occurred in this cohort, 4485 (35.9%) among never smokers, 3602 (28.9%) among current smokers, and 4396 (35.2%) among past smokers. Compared with never smokers, current smokers had an increased risk of total mortality (HR, 2.81; 95% confidence interval [CI], 2.68-2.95) and all major cause-specific mortality. The HR for cancers classified by the 2004 surgeon general's report to be smoking-related was 7.25 (95% CI, 6.43-8.18) and 1.58 (95% CI, 1.45-1.73) for other cancers. Compared with never smokers, the HR for colorectal cancer was 1.63 (95% CI, 1.29-2.05) for current smokers and 1.23 (95% CI, 1.02-1.49) for former smokers. A significant association was not observed for ovarian cancer. Significant trends were observed for earlier age at initiation of smoking for total mortality (P = .003), respiratory disease mortality (P = .001), and all smoking-related cancer mortality (P = .001). The excess risk for all-cause mortality decreases to the level of a never smoker 20 years after quitting, with different time frames for risk reduction observed across outcomes. Approximately 64% of deaths among current smokers and 28% of deaths among former smokers were attributable to cigarette smoking. CONCLUSIONS Most of the excess risk of vascular mortality due to smoking in women may be eliminated rapidly upon cessation and within 20 years for lung diseases. Postponing the age of smoking initiation reduces the risk of respiratory disease, lung cancer, and other smoking-related cancer deaths but has little effect on other cause-specific mortality. These data suggest that smoking is associated with an increased risk of colorectal cancer mortality but not ovarian cancer mortality.
A Dual Embedding Space Model for Document Ranking

A fundamental goal of search engines is to identify, given a query, documents that have relevant text. This is intrinsically difficult because the query and the document may use different vocabulary, or the document may contain query words without being relevant. We investigate neural word embeddings as a source of evidence in document ranking. We train a word2vec embedding model on a large unlabelled query corpus, but in contrast to how the model is commonly used, we retain both the input and the output projections, allowing us to leverage both the embedding spaces to derive richer distributional relationships. During ranking we map the query words into the input space and the document words into the output space, and compute a query-document relevance score by aggregating the cosine similarities across all the query-document word pairs. We postulate that the proposed Dual Embedding Space Model (DESM) captures evidence on whether a document is about a query term in addition to what is modelled by traditional term-frequency based approaches. Our experiments show that the DESM can re-rank top documents returned by a commercial Web search engine, like Bing, better than a term-matching based signal like TF-IDF. However, when ranking a larger set of candidate documents, we find the embeddings-based approach is prone to false positives, retrieving documents that are only loosely related to the query. We demonstrate that this problem can be solved effectively by ranking based on a linear mixture of the DESM and the word counting features.
Determinants of Product Innovation in Small Firms

Many studies have investigated the determinants of product innovation in small firms, suggesting product, firm, market and innovation process factors are its key drivers of success. Variations across industries relating to the determinants of product innovation are often expected, but due to a lack of data this is still under-researched. This article explores if composite effects due to broad samples indeed blur one's view. Drawing upon a database of 1250 small firms across 7 industries, we investigate if any differences are found in the presence and impact of various firm-level determinants. Controlling for size and age differences, the analysis reveals some major differences to the extent small firms use innovative practices, and their connection with new product introductions.
Cardiovascular Responses to Dynamic and Static Effort Soon after Myocardial Infarction: Application to Occupational Work Assessment

SUMMARY Static and dynamic work involving the arms and the legs was performed by 40 men seven weeks after myocardial infarction. Leg ergometry produced a significantly higher peak work load, systolic blood pressure (BPs), heart rate (HR), and HR X BPs X 10-2 product (DP) than did arm ergometry: 842 ± 178 vs 546 ± 135 kg-m/min, 176 ± 24 vs 154 ± 19 mm Hg and 256 ± 54 vs 219 ± 48 (SD). Peak heart rates were 145 and 142. Endpoints were primarily muscular and generalized fatigue and dyspnea. Ischemic abnormalities and ventricular ectopy were more frequent with leg ergometry. Sustained forearm lifting elicited higher HR, BPs and DP responses than sustained handgrip contraction: 95 ± 16 vs 91 ± 16 beats/min, 162 ± 18 vs 152 ± 17 mm Hg and 154 ± 33 vs 139 ± 33 (SD). Ischemic ST segment depression and significant ventricular arrhythmias were infrequent with static effort. Dynamic leg testing is superior to dynamic or static arm testing in assessing the capacity of patients to perform physical work tasks after myocardial infarction.
Development / Plasticity / Repair Lmx 1 b , Pet-1 , and Nkx 2 . 2 Coordinately Specify Serotonergic Neurotransmitter Phenotype

Leping Cheng,1,2* Chih-Li Chen,1,2* Ping Luo,1,2 Min Tan,3 Mengsheng Qiu,3 Randy Johnson,4 and Qiufu Ma1,2 1The Dana-Farber Cancer Institute, 2Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, 3Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292, and 4Program in Genes and Development, Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030
PESTICIDAL ACTIVITIES OF MORINGA OLEIFERA SEED OIL EXTRACT TO TRIBOLIUM CASTANEUM AND TRIBOLIUM CONFUSUM ON MILLED

A study of Pesticidal activities of Moringa oleifera seed oil extract to Rust-Red Beetles, Tribolium castaneum and Confused Flour Beetles, Tribolium confusum on milled maize was conducted in the research Laboratory of Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka, Southeastern Nigeria. This study was to investigate the mortality and repellency effects of Moriga oleifera seed oil on the stored product pests. The study was carried out under ambient temperature of 28Oc-32Oc and relative humidity of 72%-80%. The study was conducted using 5 concentration levels of 20%, 10%, 5% 2.5% and 1.25% including a control which corresponded to 200μl/ml, 100μl/ml, 50μl/ml, 25μl/ml, 12.5μl/ml, of the moringa seed oil per milliliter. Mortality and repellency data were recorded and probit analysis carried out to determine the LD50 values. LD50 were determined to be 1. 78μl/ml, 1. 67μl/ml, 1. 67μl/ml, and 1. 9μl/ml, for direct application on Tribolium castaneum, direct application on Tribolium confusum, residual filter paper treatment on Tribolium castaneum and residual filter paper treatment on Tribolium confusum respectively. There were no significant differences in mortality and repellency effects recorded within and between the groups (P≥0.05). The studies showed that moriga seed oil has poor mortality and repellency effects to the insect pests as not more than 6.6% mortality or repellency effects were recorded in any of the treatments.
Improved Balance Confidence and Stability for Elderly After 6 Weeks of a Multimodal Self-Administered Balance-Enhancing Exercise Program

Objective: To develop and assess the efficacy of a multimodal balance-enhancing exercise program (BEEP) designed to be regularly self-administered by community-dwelling elderly. The program aims to promote sensory reweighting, facilitate motor control, improve gaze stabilization, and stimulate continuous improvement by being constantly challenging. Method: Forty participants aged 60 to 80 years performed 6 weeks of BEEP training, on average for 16 min four times weekly, in a randomized one-arm crossover design. Results: One-leg standing time improved 32% with eyes open (EO), 206% with eyes closed (EC) on solid surface, and 54% EO on compliant surface (p < .001). Posturography confirmed balance improvements when perturbed on solid and compliant surfaces with EO and EC (p ≤ .033). Walking, step stool, and Timed Up and Go speeds increased (p ≤ .001), as did scores in Berg Balance and balance confidence scales (p ≤ .018). Discussion: Multimodal balance exercises offer an efficient, cost-effective way to improve balance control and confidence in elderly.
Capacity of sparse wideband channels with partial channel feedback

This paper studies the ergodic capacity of wideband multipath channels with partial/limited channel state feedback. Our work builds on recent results that show a significant capacity gain in the wideband/low-SNR regime when there is perfect channel state information (CSI) at the transmitter and the receiver, relative to the case of perfect CSI at the receiver only. Furthermore, this benchmark capacity gain can be achieved with just one bit of feedback per channel coefficient. However, the input signals used in these works are peaky; that is, they have large peak-to-average power ratios. Signal peakiness requirement is related to channel coherence and many recent measurement campaigns show that, in contrast to previous assumptions, wideband channels exhibit a sparse multipath structure that naturally leads to coherence in time and frequency. In this work, we show that multipath sparsity significantly relaxes the requirement of peaky signalling in attaining the capacity gains with channel state feedback. First, we show that the benchmark capacity gain, with perfect CSI at the transmitter and the receiver, is achievable even under an instantaneous power constraint. In the more realistic non-coherent setting, we study the performance of a training-based signalling scheme with one bit of feedback per channel coefficient. We show that multipath sparsity can be leveraged to achieve the benchmark capacity gain under both average as well as instantaneous power constraints as long as the channel coherence scales at a sufficiently fast rate with the signal space dimension (time-bandwidth product). We also present guidelines for choosing signalling parameters as a function of the channel sparsity parameters to maximally exploit channel state feedback for capacity gains. Copyright © 2008 John Wiley & Sons, Ltd.
Use of internal splinting to realign a noncompliant sternum in a cat with pectus excavatum.

CASE DESCRIPTION A 5.5-month-old female domestic longhair cat was examined because of dorsal deviation of the caudal aspect of the sternum and progressively worsening dyspnea during play activities. CLINICAL FINDINGS A diagnosis of pectus excavatum was made clinically and confirmed radiographically. The cardiac silhouette was shifted into the right hemithorax. The vertebral index (VI) and frontosagittal index (FSI), which are radiographic indices used to grade the extent of the deformity, were 5.2 and 3.0, respectively. Minimum thoracic height was 13 mm at this time. TREATMENT AND OUTCOME The sternal malposition was corrected during surgery; for stabilization, an internal splint was provided by use of a plate that was applied to the ventral side of the sternum. Radiographic indices improved until day 85; at that time, an increase in the distance between plate and sternum was detected, and plate removal was advised. The radiographic indices improved again after plate removal. At 310 days after surgery, VI was 9.6, FSI was 1.6, and minimum thoracic height was 34 mm. No dyspnea was evident during physical examination. CLINICAL RELEVANCE Results of treatment suggest that this technique may be useful as an alternative surgical option for cats with pectus excavatum that have a noncompliant sternum.
Modeling of audiovisual speech perception in noise

We present three models of audiovisual speech perception at varying signal-to-noise ratios (SNR). The first model is Massaro’s Fuzzy Logical Model of Perception (FLMP) applied at each SNR. The second model imposes the constraint that the visual response probabilities are the same regardless of the SNR. Both models describe the data well. Root Mean Squared Error (RMSE) corrected for the numbers of degrees of freedom was smaller for the latter model. In concordance, cross validated paired t-test showed that the latter model was significantly better at predicting individual performance despite the lower number of parameters. In a third model – a weighted FLMP – the SNR is parameterized reducing the number of free parameters substantially. This model fits the data significantly worse than the other two models, but does capture salient features of the change in performance with varying SNR.
Gender Differences in Taiwan University Students' Attitudes toward the Web-based Learning

This study explored gender differences on university students' attitudes toward Web-based learning in Taiwan. A Web-based Learning Attitude Survey (WLAS) was developed. The WLAS consisted of five scales, including access, social structure, content, pedagogy, and community relationship toward Web-based learning. By using an online survey, this study gathered the responses of 1,866 Taiwanese university students (940 males and 926 females) whose ages ranged from 18 to 23. The results showed significant gender differences in the aspects of social structure, content, and community relationship involved in Web-based learning. Interestingly, although females might consider the Internet a masculine-dominated technology, they displayed more favorable attitudes than males did regarding the impacts of socioeconomic status (the social structure scale) on students' performance of Web-based learning. Moreover, females possessed more positive attitudes than males toward the helpfulness and variety of the content for Web learning. However, they did not think the virtual interaction on the Internet could develop adequate teacher-student and peer relationships (the community relationship scale). Some follow-up interviews were also conducted with selected students, and the implications derived from this study were discussed.
Efficient Anonymous Multireceiver Certificateless Encryption

To protect receiver privacy, researchers constructed anonymous multireceiver encryption by implanting anonymity in multireceiver encryption. It allows a sender to produce the identical ciphertext for multiple designated receivers. Every designated receiver can decrypt the ciphertext, but does not know who the other designated receivers are. Recently, several anonymous multireceiver identity (ID)-based encryption (AMIBE) schemes were proposed without the utilization of certificates. However, these AMIBE schemes are not efficient because their decryption cost of each receiver grows linearly with the number of the designated receivers. Moreover, all the ID-based cryptographic schemes suffer from the key escrow problem, which has been resolved by using certificateless public key settings. Very recently, Islam et al. proposed an anonymous multireceiver certificateless encryption (AMCLE) scheme. However, the encryption cost of a sender is quadric with the number of designated receivers, whereas the decryption cost of each receiver is linear with the number. In this paper, we propose an efficient AMCLE scheme with constant decryption cost, namely, the required decryption cost of each receiver is independent of the number of receivers. When compared with previously proposed AMIBE and AMCLE schemes, our scheme solves the key escrow problem and improves the efficiency of encryption/decryption significantly as well.
Attitudes toward opioids for refractory dyspnea in COPD among Dutch chest physicians

Dyspnea is the most frequently reported symptom of outpatients with advanced chronic obstructive pulmonary disease (COPD). Opioids are an effective treatment for dyspnea. Nevertheless, the prescription of opioids to patients with advanced COPD seems limited. The aims of this study are to explore the attitudes of Dutch chest physicians toward prescription of opioids for refractory dyspnea to outpatients with advanced COPD and to investigate the barriers experienced by chest physicians toward opioid prescription in these patients. All chest physicians (n = 492) and residents in respiratory medicine (n = 158) in the Netherlands were invited by e-mail to complete an online survey. A total of 146 physicians (response rate 22.5%) completed the online survey. Fifty percent of the physicians reported to prescribe opioids for refractory dyspnea in 20% or less of their outpatients with advanced COPD and 18.5% reported never to prescribe opioids in these patients. The most frequently reported barriers toward prescription of opioids were resistance of the patient, fear of possible adverse effects, and fear of respiratory depression. To conclude, Dutch chest physicians and residents in respiratory medicine rarely prescribe opioids for refractory dyspnea to outpatients with advanced COPD. This reluctance is caused by perceived resistance of the patient and fear of adverse effects, including respiratory adverse effects.
Heuristics for the evaluation of captchas on smartphones

Captchas are used as a security mechanism on the web to distinguish human users from automated programs. However, existing captchas are not well-adapted to mobile devices and may lead users to abandon tasks. Although Web developers have many available captchas, they lack the tools to evaluate if these captchas are suitable for their mobile site. In this paper, we present domain specific usability heuristics for evaluating captchas on smartphones. To assess effectiveness, we compared our proposed heuristics against Nielsen's during evaluations of four captcha schemes on smartphones. The custom heuristics revealed more major problems and more detailed feedback on the problems than Nielsen's.