Miracle-dz/UniFAR-FTUs huggingface dataset:
Robust optimization for intensity modulated radiation therapy treatment planning under uncertainty

The recent development of intensity modulated radiation therapy (IMRT) allows the dose distribution to be tailored to match the tumour's shape and position, avoiding damage to healthy tissue to a greater extent than previously possible. Traditional treatment plans assume that the target structure remains in a fixed location throughout treatment. However, many studies have shown that because of organ motion, inconsistencies in patient positioning over the weeks of treatment, etc, the tumour location is not stationary. We present a probabilistic model for the IMRT inverse problem and show that it is identical to using robust optimization techniques, under certain assumptions. For a sample prostate case, our computational results show that this method is computationally feasible and promising—compared to traditional methods, our model has the potential to find treatment plans that are more adept at sparing healthy tissue while maintaining the prescribed dose to the target.
Altered diastolic function and aortic stiffness in Alzheimer’s disease

Background Alzheimer’s disease (AD) is closely linked to cardiovascular risk factors. Methods Echocardiographic studies were performed, including left ventricular diastolic functions, left and right atrial conduction times, and arterial stiffness parameters, namely stiffness index, pressure-strain elastic modulus, and distensibility, on 29 patients with AD and 24 age-matched individuals with normal cognitive function. Results The peak mitral flow velocity of the early rapid filling wave (E) was lower, and the peak velocity of the late filling wave caused by atrial contraction (A), deceleration time of peak E velocity, and isovolumetric relaxation time were higher in the AD group. The early myocardial peak (Ea) velocity was significantly lower in AD patients, whereas the late diastolic (Aa) velocity and E/Ea ratio were similar between the two groups. In Alzheimer patients, stiffness index and pressure-strain elastic modulus were higher, and distensibility was significantly lower in the AD group compared to the control. Interatrial electromechanical delay was significantly longer in the AD group. Conclusion Our findings suggest that patients with AD are more likely to have diastolic dysfunction, higher atrial conduction times, and increased arterial stiffness compared to the controls of same sex and similar age.
Interannual and interdecadal variability of the summertime western North Pacific subtropical high

The western North Pacific Subtropical High (WNPSH) in summer exhibits significant 2–3 years and 3–5 years oscillations with interdecadal variability. The 2–3‐year oscillation is most evident after 1990. It is accompanied by anomalous meridional overturning circulation characterized by warm SST anomalies (SSTA) and ascending motion in the maritime continent and anomalous descending motion near the Philippine Sea, and by evolving warm to cold SSTA in the central‐eastern Pacific from the preceding winter to the summer. The 3–5‐year oscillation is most pronounced during the 1980s. It is accompanied by anomalous descending motion over the maritime continent and warm SSTA in the central‐eastern equatorial Pacific that persists from the preceding winter to the summer; the complementary cooling and descending motion in the western Pacific are related to anomalous east‐west circulation associated with ENSO.
An approach to assess the quality of collaboration in technology-mediated design situations

Our objective is to measure and compare the quality of collaboration in technology-mediated design activities. Our position is to consider collaboration as multidimensional. We present a method to assess quality of collaboration which is composed of seven dimensions concerning communication processes such as grounding, coordination processes, task-related processes, symmetry of individual contributions as well as motivational processes. This method is used in a study aiming to compare the quality of collaboration in architectural design. In this experimental study, design situations vary according to technology-mediation - co-presence with an augmented reality (AR) environment versus distance with AR and visio-conferencing -, and according to number of participants - pairs versus groups of four architects -. Our results show that distinctive dimensions of collaboration are affected by the technology mediation and/or the number of co-designers. We discuss these results with respect to technology affordances such as visibility and group factors.
Chronic Pain Management: American Society of Anesthesiologists Closed Claims Project

BackgroundThe practice of chronic pain management has grown steadily in recent years. The purpose of this study was to identify and describe issues and trends in liability related to chronic pain management by anesthesiologists. MethodsData from 5,475 claims in the American Society of Anesthesiologists Closed Claims Project database between 1970 and 1999 were reviewed to compare liability related to chronic pain management with that related to surgical and obstetric (surgical/obstetric) anesthesia. Acute pain management claims were excluded from analysis. Outcomes and liability characteristics between 284 pain management claims and 5,125 surgical/obstetric claims were compared. ResultsClaims related to chronic pain management increased over time (P < 0.01) and accounted for 10% of all claims in the 1990s. Compensatory payment amounts were lower in chronic pain management claims than in surgical/obstetric anesthesia claims from 1970 to 1989 (P < 0.05), but during the 1990s, there was no difference in size of payments. Nerve injury and pneumothorax were the most common outcomes in invasive pain management claims. Epidural steroid injections accounted for 40% of all chronic pain management claims. Serious injuries, involving brain damage or death, occurred with epidural steroid injections with local anesthetics and/or opioids and with maintenance of implantable devices. ConclusionsFrequency and payments of claims associated with chronic pain management by anesthesiologists increased in the 1990s. Brain damage and death were associated with epidural steroid injection only when opioids or local anesthetics were included. Anesthesiologists involved in home care of patients with implanted devices such as morphine pumps and epidural injections or patient-controlled analgesia should be aware of potential complications that may have severe outcomes.
News Trading and Speed

We compare the optimal trading strategy of an informed speculator when he can trade ahead of incoming news (is “fast”), versus when he cannot (is “slow”). We find that speed matters: the fast speculator's trades account for a larger fraction of trading volume, and are more correlated with short-run price changes. Nevertheless, he realizes a large fraction of his profits from trading on long-term price changes. The fast speculator's behavior matches evidence about high-frequency traders. We predict that stocks with more informative news are more liquid even though they attract more activity from informed high-frequency traders.
Union representation, collective voice and job quality: An analysis of a survey of union members in the UK finance sector

This article seeks to identify whether employee perceptions of job quality are better in instances where an onsite union representative is present. It also seeks to identify whether the relationship between onsite representative presence and job quality is explained by employee perceptions of union collective voice. The analysis, based on a survey of union members in the UK finance sector, demonstrates that employee perceptions of several dimensions of job quality are better where an onsite representative is present, and that this can be explained by the higher perceptions of union collective voice that onsite representatives engender.
On the structure of the Schr\"odinger propagator

We discuss the form of the propagator $U(t)$ for the time-dependent Schr\"odinger equation on an asyptotically Euclidean, or, more generally, asymptotically conic, manifold with no trapped geodesics. In the asymptotically Euclidean case, if $\chi \in \mathcal{C}_0^\infty$, and with $\mathcal{F}$ denoting Fourier transform, $\mathcal{F}\circ e^{-ir^2/2t} U(t) \chi$ is a Fourier integral operator for $t\neq 0. $ The canonical relation of this operator is a ``sojourn relation'' associated to the long-time geodesic flow. This description of the propagator follows from its more precise characterization as a ``scattering fibered Legendrian,'' given by the authors in a previous paper and sketched here. A corollary is a propagation of singularities theorem that permits a complete description of the wavefront set of a solution to the Schr\"odinger equation, restricted to any fixed nonzero time, in terms of the oscillatory behavior of its initial data. We discuss two examples which illustrate some extremes of this propagation behavior.
Programming from Galois Connections — Principles and Applications ( Extended version of reference [ 16 ] )

Problem statements often resort to superlatives such as in eg. “. the smallest such number”, “. the best approximation”, “. the longest such list” which lead to specifications made of two parts: one defining a broad class of solutions (the easy part) and the other requesting one particular such solution optimal in some sense (the hard part). This report introduces a binary relational combinator which mirrors this linguistic structure and exploits its potential for calculating programs by optimization. This applies in particular to specifications written in the form of Galois connections, in which one of the adjoints delivers the optimal solution. The framework encompasses re-factoring of results previously developed by by Bird and de Moor for greedy and dynamic programming, in a way which makes them less technically involved and therefore easier to understand and play with.
Signal recognition particle immunoglobulin g detected incidentally associates with autoimmune myopathy

Introduction: Paraneoplastic autoantibody screening of 150,000 patient sera by tissue‐based immunofluorescence incidentally revealed 170 with unsuspected signal recognition particle (SRP) immunoglobulin G (IgG), which is a recognized biomarker of autoimmune myopathy. Of the 77 patients with available information, 54 had myopathy. We describe the clinical/laboratory associations. Methods: Distinctive cytoplasm‐binding IgG (mouse tissue substrate) prompted western blot, enzyme‐linked immunoassay, and immunoprecipitation analyses. Available histories were reviewed. Results: The immunostaining pattern resembled rough endoplasmic reticulum, and mimicked Purkinje‐cell cytoplasmic antibody type 1 IgG/anti‐Yo. Immunoblotting revealed ribonucleoprotein reactivity. Recombinant antigens confirmed the following: SRP54 IgG specificity alone (17); SRP72 IgG specificity alone (3); both (32); or neither (2). Coexisting neural autoantibodies were identified in 28% (low titer). Electromyography revealed myopathy with fibrillation potentials; 78% of biopsies had active necrotizing myopathy with minimal inflammation, and 17% had inflammatory myopathy. Immunotherapy responsiveness was typically slow and incomplete, and relapses were frequent on withdrawal. Histologically confirmed cancers (17%) were primarily breast and hematologic, with some others. Conclusions: Autoimmune necrotizing SRP myopathy, both idiopathic and paraneoplastic, is underdiagnosed in neurological practice. Serological screening aids early diagnosis. Cancer surveillance and appropriate immunosuppressant therapy may improve outcome. Muscle Nerve 53: 925–932, 2016
Constructive and instructive representation

Abstract Beginning teachers of mathematics are likely to have noted the development of powerful multiple representation software which offers children access to the many modalities through which mathematics is expressed. We argue that embedded, even hidden, within such software are many mathematics conventions, which the naive learner has to unravel in order to construct meaning for those representations. We contrast such representations, which we label as instructive, with those children construct through the use of expressive software; this contrast is seen as analogous to aspects of literacy. We identify various characteristics of these two distinctive forms of representation.
Responsibility for nurturing a child’s wellbeing: teachers teaching mindfulness with children

ABSTRACT A thriving and evolving pool of research and commentary is emerging in relation to the integration of mindfulness techniques in school and out-of-school settings. In the current study the author explored how experienced mindbody wellness instructors make sense of teaching children mindfulness. The methodology of Interpretative Phenomenological Analysis was used to interview eight teachers teaching mindfulness with children from the United States and Australia. Four thematic categories emerged from the analysis and in this article the author discusses findings related to the theme of, Responsibility for Nurturing a Child’s Wellbeing. It was discovered that having a holistic-wellness-orientated vision was an important aspect of how teachers made sense of mindfulness instruction. The findings showed that teaching children mindfulness has the capacity to raise academic performance while synergistically enhancing a child’s spiritual, environmental, emotional, social, creative and physical wellbeing. It is recommended that mindfulness teacher training programs be established in universities to better prepare students to meet the demands of 21st Century education.
The interaction between virtual channel flow control and adaptive routing in wormhole networks

Multiprocessor interconnection networks based on low dimensional mesh or torus topologies and employing wormhole switching have become increasingly popular. Two concepts that have been proposed to improve the performance of such networks are Virtual Channel Flow Control (VCFC) and adaptive routing. Some previous studies have, however, found the latter technique to yield disappointing performance under uniform traffic patterns, while in this work we show that the former technique may result in degraded performance under certain non-uniform traffic patterns. This paper studies the interaction between VCFC and adaptive routing. It is shown that each of these techniques may yield unsatisfactory performance only when used in isolation, and that through their appropriate combination uniformly improved performance can be achieved. The consistent performance improvement and the magnitude of the performance improvement in some cases offers compelling motivation for implementing a combination of VCFC and adaptive routing in future machines.
The Dynamical Systems Properties of the HOG Signaling Cascade

The High Osmolarity Glycerol (HOG) MAP kinase pathway in the budding yeast Saccharomyces cerevisiae is one of the best characterized model signaling pathways. The pathway processes external signals of increased osmolarity into appropriate physiological responses within the yeast cell. Recent advances in microfluidic technology coupled with quantitative modeling, and techniques from reverse systems engineering have allowed yet further insight into this already well-understood pathway. These new techniques are essential for understanding the dynamical processes at play when cells process external stimuli into biological responses. They are widely applicable to other signaling pathways of interest. Here, we review the recent advances brought by these approaches in the context of understanding the dynamics of the HOG pathway signaling.
Real-Time Multipedestrian Tracking in Traffic Scenes via an RGB-D-Based Layered Graph Model

Multipedestrian tracking in traffic scenes is challenging due to cluttered backgrounds and serious occlusions. In this paper, we propose a layered graph model in image (RGB) and depth (D) domains for real-time robust multipedestrian tracking. The motivation is to investigate high-level constraints in RGB-D data association and to improve the optimization from the trajectory level to the layer level. To construct a layered graph, we define constraints in the depth domain so that pedestrian objects in the image domain are assigned to proper layers. We use pedestrian detection responses in the RGB domain as graph nodes, and we integrate 3-D motion, appearance, and depth features as graph edges. An online updating depth factor is defined to describe the depth relationships among the observations in and out of the layers, and the occlusion issue is processed with an analytical layer-level strategy. With a heuristic label switching algorithm, multiple pedestrian objects are optimally associated and tracked. Experiments and comparison on five public data sets show that our proposed approach significantly reduces pedestrian's ID switch and improves tracking accuracy in the cases of serious occlusions.
Modified Melodic Intonation Therapy for Acquired Non-Fluent Aphasia

For decades Melodic Intonation Therapy (MIT) has shown good potential within the aphasia population, yet has seldom been used as a frontline treatment, rather placed within a myriad of treatment techniques utilized during aphasia therapy. Debate continues regarding the mechanisms of change from MIT, both therapeutically and neurologically. Modified Melodic Intonation Therapy (MMIT) has developed through the work of Music Therapists and, as the main focus of treatment for non-fluent aphasia, can be an effective means of language re-acquisition for improved speech production. Clinical results from 7 clients with chronic non-fluent aphasia who received MMIT are discussed.
Capsular Types of Klebsiella pneumoniae Revisited by wzc Sequencing

Capsule is an important virulence factor in bacteria. A total of 78 capsular types have been identified in Klebsiella pneumoniae. However, there are limitations in current typing methods. We report here the development of a new genotyping method based on amplification of the variable regions of the wzc gene. Fragments corresponding to the variable region of wzc were amplified and sequenced from 76 documented capsular types of reference or clinical strains. The remaining two capsular types (reference strains K15 and K50) lacked amplifiable wzc genes and were proven to be acapsular. Strains with the same capsular type exhibited ≧94% DNA sequence identity across the variable region (CD1-VR2-CD2) of wzc. Strains with distinct K types exhibited <80% DNA sequence identity across this region, with the exception of three pairs of strains: K22/K37, K9/K45, and K52/K79. Strains K22 and K37 shared identical capsular polysaccharide synthesis (cps) genes except for one gene with a difference at a single base which resulted in frameshift mutation. The wzc sequences of K9 and K45 exhibited high DNA sequence similarity but possessed different genes in their cps clusters. K52 and K79 exhibited 89% wzc DNA sequence identity but were readily distinguished from each other at the DNA level; in contrast, strains with the same capsular type as K52 exhibited 100% wzc sequence identity. A total of 29 strains from patients with bacteremia were typed by the wzc system. wzc DNA sequences confirmed the documented capsular type for twenty-eight of these clinical isolates; the remaining strain likely represents a new capsular type. Thus, the wzc genotyping system is a simple and useful method for capsular typing of K. pneumoniae.
Macular dysfunction in drusen maculopathy assessed with multifocal electroretinogram and optical coherence tomography

Purpose To study the relationship between macular function assessed by multifocal electroretinogram (mfERG) and morphological changes evaluated with optical coherence tomography (OCT) and fundus photography in patients with drusen maculopathy. Methods Ten patients (age 71 ± 5 years) with drusen maculopathy were compared to fifteen healthy control patients (age 67 ± 7 years). One eye per patient was examined with OCT, color fundus pictures, and mfERG (103 hexagons) recorded in nine areas corresponding to the nine areas of the OCT retinal map. Drusen density for every separated area was registered. Results All nine areas in the maculopathy group demonstrated prolonged implicit time compared to healthy controls; the mean value for the maculopathy group was 31.3 milliseconds (95% confidence intervals [CI]: 30.9–31.6) vs 27.9 milliseconds (95% CI: 27.5–28.2; P = 0.006) for the control group. The amplitude in the foveal area was lower in the maculopathy group; the mean value for the maculopathy group was 25.1 nV/deg2 (95% CI: 18.4–31.7) vs 33.9 nV/deg2 (95% CI: 27–40.9; P = 0.03) for the control group. mfERG in the maculopathy group demonstrated no differences in areas with or without drusen. There was no correlation between the retinal thickness assessed with OCT and the mfERG response. Conclusion Eyes with drusen maculopathy demonstrated functional changes compared to healthy controls evaluated with mfERG. Drusen seems to be associated with general macular dysfunction.
Optimal Toeholds in Takeover Contests

We offer an explanation for why raiders do not acquire the maximum possible toehold prior to announcing a takeover bid. By endogenously modeling the target firm's value following an unsuccessful takeover we demonstrate that a raider may optimally acquire a small toehold even if the acquisition does not drive up the pre-tender target price. This occurs because although a larger toehold increases profits if the takeover succeeds it also conveys a higher level of managerial entrenchment and hence a lower firm value if the takeover fails. We derive new predictions regarding the optimal toehold and target value following a failed takeover. We also examine the impact of a rival bidder and dilution.
An Analysis of Quantitative Aspects in the Evaluation of Thematic Segmentation Algorithms

We consider here the task of linear the-matic segmentation of text documents, by using features based on word distributions in the text. For this task, a typical and often implicit assumption in previous studies is that a document has just one topic and therefore many algorithms have been tested and have shown encouraging results on artificial data sets, generated by putting together parts of different documents. We show that evaluation on synthetic data is potentially misleading and fails to give an accurate evaluation of the performance on real data. Moreover, we provide a critical review of existing evaluation metrics in the literature and we propose an improved evaluation metric.
Characterization of Fear Memory Reconsolidation

Reactivation of consolidated memories returns them to a protein synthesis-dependent state. One interpretation of these findings is that the memory reconsolidates after use. Two alternative interpretations are that protein synthesis inhibition facilitates extinction and that postreactivation protein synthesis inhibition leads to an inability to retrieve the consolidated memory. First, using two different approaches, we report that reconsolidation cannot be reduced down to facilitated extinction. We show that the reconsolidation deficit does not show renewal after a contextual shift, whereas an extinguished auditory fear memory does under the same conditions and the deficit occurs regardless of whether the memory is reactivated with an extinction [conditioned stimulus (CS) alone] or a reinforced trial (CS-unconditioned stimulus). To address the issue of whether postreactivation anisomycin leads to an inability to retrieve the consolidated memory, we used two traditional assays for retrieval deficits. First, we demonstrate that the amnesia induced by blockade of reconsolidation does not show any spontaneous recovery. Second, we show that application of reminder shock does not result in the reinstatement of the memory. These findings support the idea that reactivation of consolidated memories initiates a second time-dependent memory formation process.