Miracle-dz/UniFAR-FTUs huggingface dataset:
Anarchic Society Optimization Based PID Control of an Automatic Voltage Regulator (AVR) System

This paper addresses a robust method for optimal PID control of Automatic Voltage Regulation (AVR) system to damp terminal voltage oscillation following disturbances in power systems. The optimization is carried out by the Anar- chic Society Optimization (ASO) algorithm which is inspired by a social grouping in which members behave anarchically to improve their situation. The optimal tuning problem of the PID gains to control of AVR system against parametric uncer- tainties is formulated as an optimization problem according to time domain based objective function. It is solved by the ASO algorithm which has a strong ability to find the most optimistic results to reduce control system effort and find optimal design. It is carried out under multiple operation conditions to achieve the desired level of terminal voltage regulation. The effec- tiveness of the optimized PID controller with ACO algorithm is investigated under system parameter changes in comparison with the results of PID controller tuned via of the recently reported optimization method like the craziness based Particle Swarm Optimization (PSO) and Vector Evaluated PSO (VEPSO) approaches. The simulation results is depicted to illustrate robust performance of the proposed ASO technique for enhancement transient stability of AVR system that of the other heuristics methods in the literature. The results analysis reveals that the ASO based PID type AVR control system is effective and provides good terminal voltage oscillations damping ability. Moreover, it is superior that of the other PSO method in terms of accuracy, convergence and computational effort.
The Stability of Personality Disorder Diagnoses

Although there has been an increase in the number of studies examining the outcome of patients with personality disorders, little attention has been given to assessing the stability of personality disorder diagnoses. The stability, or lack of stability, of personality disorder diagnoses is an important issue that can be addressed empirically and could play a role in future decisions about the diagnostic nomenclature.
Nanotechnology: public concerns, reasoning and trust in government

Public perceptions of emergent technologies have become increasingly important to understand, in part due to the worldwide backlash against genetically modified foods, which effectively stalled a new industry. In this context, and given the predicted importance of nanotechnology, this article reports an investigation of US citizens' concerns about nanotechnology development. The study investigated both the perceptions of informed citizens and the reasoning basis underlying concerns, as well as explored public concerns in relation to four projected applications of nanotechnology. Two of the applications investigated were thought to be potentially controversial and, thus, perhaps particularly important to formation of public opinion. Results presented here include concerns that were consistent across the study sample, and concerns specific to different regions of the United States. The study found low trust in government to manage risks, and that medical and industrial uses were related to lowest trust in government to manage risks. Higher education levels were also related to lower trust in government to effectively manage risks. Study participants' concerns were largely based on experiential knowledge about past “breakthroughs” whose limitations and negative effects were poorly understood initially, and even when once known, were poorly managed.
Filtering-based automatic cloze test generation

We propose a method to generate high-quality cloze test questions using a computational approach. Previous methods for automatic cloze test generation have contained some problems; specifically, there can be multiple correct answers. We found that approximately 50% of the generated answers have such errors with previous methods, which requires human post-editing was necessary in previous research. We propose an N-gram filtering method that can detect the answer to a given question. We compare the errors of the generated questions before and after applying the filtering methods. We found that our filtering method can select quality distractors by reducing errors in the generated questions. Moreover, when we generate cloze tests using semantic similarity, non-native speakers are very hard to answer the questions.
Identification of Chromosomal Errors in Human Preimplantation Embryos with Oligonucleotide DNA Microarray

A previous study comparing the performance of different platforms for DNA microarray found that the oligonucleotide (oligo) microarray platform containing 385K isothermal probes had the best performance when evaluating dosage sensitivity, precision, specificity, sensitivity and copy number variations border definition. Although oligo microarray platform has been used in some research fields and clinics, it has not been used for aneuploidy screening in human embryos. The present study was designed to use this new microarray platform for preimplantation genetic screening in the human. A total of 383 blastocysts from 72 infertility patients with either advanced maternal age or with previous miscarriage were analyzed after biopsy and microarray. Euploid blastocysts were transferred to patients and clinical pregnancy and implantation rates were measured. Chromosomes in some aneuploid blastocysts were further analyzed by fluorescence in-situ hybridization (FISH) to evaluate accuracy of the results. We found that most (58.1%) of the blastocysts had chromosomal abnormalities that included single or multiple gains and/or losses of chromosome(s), partial chromosome deletions and/or duplications in both euploid and aneuploid embryos. Transfer of normal euploid blastocysts in 34 cycles resulted in 58.8% clinical pregnancy and 54.4% implantation rates. Examination of abnormal blastocysts by FISH showed that all embryos had matching results comparing microarray and FISH analysis. The present study indicates that oligo microarray conducted with a higher resolution and a greater number of probes is able to detect not only aneuploidy, but also minor chromosomal abnormalities, such as partial chromosome deletion and/or duplication in human embryos. Preimplantation genetic screening of the aneuploidy by DNA microarray is an advanced technology used to select embryos for transfer and improved embryo implantation can be obtained after transfer of the screened normal embryos.
GABRG2 C588T gene polymorphisms might be a predictive genetic marker of febrile seizures and generalized recurrent seizures: a case-control study in a Romanian pediatric population

Introduction This case-control study aimed to assess two single nucleotide polymorphisms of the gene encoding the GABRG2 protein – GABRG2 (3145 G>A) and GABRG2 rs 211037 Asn196Asn (C588T) – in a cohort of pediatric patients from Romania, and evaluate their possible impact on drug-resistant forms of generalized epilepsy and recurrent febrile seizures. Material and methods One hundred and fourteen children with idiopathic generalized epilepsy (group 1) or febrile seizures (group 2) were compared to 153 controls. Peripheral blood samples were assessed using polymerase chain reaction-restriction fragment length polymorphism analysis, with results interpreted based on the disappearance of a restriction site in the C allele (122 bp) compared to the T allele (100 bp + 22 bp). Results A significant association was found with the TT homozygous genotype and T allele for both febrile seizures and epilepsy for the C588T locus, while GABRG2 G>A 3145 showed no significant association with any type of seizure. The TT homozygous genotype of GABRG2 Asn196Asn polymorphism was more frequent in patients with a history of febrile seizures (p = 0.0001), without a significant association identified for GABRG2-G>A 3145. Composite analysis showed associations with epilepsy for CC-AG (p = 0.02) and CT-AG (p = 0.007) with the CC-AA combination as reference. Conclusions C588T polymorphism of the GABRG2 gene might be a predictive genetic marker in triggering febrile convulsions. GABRG2 rs211037 TT homozygotes and T allele variants have an increased risk for developing febrile seizures. Recurrent crises and repeated episodes of seizures are more frequent in the GABRG2 Asn196Asn TT genotype polymorphism, with a 45 and 8 times higher risk of developing idiopathic generalized epilepsy and recurrent febrile seizures, respectively.
Selection Criteria for Postdoctoral Fellowships in Clinical Neuropsychology

A survey addressing the specific selection criteria used by postdoctoral fellowship programs in clinical neuropsychology was mailed to the 64 programs listed in The Clinical Neuropsychologist (Cripe, 1995). A total of 50 replies were received, yielding a response rate of 78%. Data suggest that the five most important selection criteria are (1) general clinical experience, (2) formal interview, (3) experience with neuropsychological assessment, (4) familiarity with the applicant's supervisor and informal contacts, and (5) experience with intelligence measures. Preferences of approach to assessment, degree type, and degree specialty were also identified.
The meaning of post-apartheid Zulu media

Abstract This article explores the relationship between certain South African media corporations, growing post-apartheid Zulu media platforms, the size and diversity of Zulu-speaking media consumers, and the historical socio-cultural construction of ‘Zuluness’. This relationship, this author observes, manifests largely through media corporations’ increasing recognition of Zulu people's pride in Zulu (i.e. the language) and ‘Zuluness’ – all of which are historical products of various forms of socialisation. Coopting this pride, profit-driven media corporations are commodifying Zulu and ‘Zuluness’. This commodification via the establishment of Zulu media outlets is paradoxical: 1) it is a transformation of a public and open Zulu cultural sense of ‘being’ into institutionally determined commodities exchangeable for revenue, for the ultimate benefit of media owners other than the masses of Zulus themselves; 2) it is a form of commoditisation that gives Zulu a linguistic profile that has historically been accorded only to English and Afrikaans. This article's argument is further briefly articulated through various intellectual frames: Graham Murdoch and Peter Golding's conceptualisation of critical political economy of communications and culture (2005); John and Jean Comaroff's anthropological analysis of commercialisation of ethnicity (2009); and, for South African specificity and precedent, through Herman Wasserman's reading of Afrikaans media corporations’ commercialisation of Afrikaans language and identity. Then the question is: What does the explored relationship mean for South Africa's multilingualism?
Treasure in Jars of Clay: The Promise of Weakness as Point of Contact Between the Generations

In churches, as well as society, we have become used to separating the generations; youth and age have little in common, so we are told. This article argues for commonality of vulnerability and weakness between young and old, and explores ways of connecting young and old together. The two authors, one in youth ministry, the other in ageing ministry, bring their knowledge of youth ministry and ageing to the dialogue. The common starting point for the dialogue is St. Paul’s image of treasure in jars of clay. It is argued that this image can equally be applied to both young and old. It is argued that young and old people need each other, for learning, spiritual growth, and support, one for the other. Issues of meaning, materialism, isolation, weakness, and vulnerability form parts of the dialogue. Suggestions arising from St. Paul’s image of treasure in jars of clay are made for making connections between the generations.
An International Contrast of Rates of Placental Abruption: An Age-Period-Cohort Analysis

Background Although rare, placental abruption is implicated in disproportionately high rates of perinatal morbidity and mortality. Understanding geographic and temporal variations may provide insights into possible amenable factors of abruption. We examined abruption frequencies by maternal age, delivery year, and maternal birth cohorts over three decades across seven countries. Methods Women that delivered in the US (n = 863,879; 1979–10), Canada (4 provinces, n = 5,407,463; 1982–11), Sweden (n = 3,266,742; 1978–10), Denmark (n = 1,773,895; 1978–08), Norway (n = 1,780,271, 1978–09), Finland (n = 1,411,867; 1987–10), and Spain (n = 6,151,508; 1999–12) were analyzed. Abruption diagnosis was based on ICD coding. Rates were modeled using Poisson regression within the framework of an age-period-cohort analysis, and multi-level models to examine the contribution of smoking in four countries. Results Abruption rates varied across the seven countries (3–10 per 1000), Maternal age showed a consistent J-shaped pattern with increased rates at the extremes of the age distribution. In comparison to births in 2000, births after 2000 in European countries had lower abruption rates; in the US there was an increase in rate up to 2000 and a plateau thereafter. No birth cohort effects were evident. Changes in smoking prevalence partially explained the period effect in the US (P = 0.01) and Sweden (P<0.01). Conclusions There is a strong maternal age effect on abruption. While the abruption rate has plateaued since 2000 in the US, all other countries show declining rates. These findings suggest considerable variation in abruption frequencies across countries; differences in the distribution of risk factors, especially smoking, may help guide policy to reduce abruption rates.
The transfer of rats from a familiar to a novel environment prolongs the increase of extracellular dopamine efflux induced by CCK8 in the posterior nucleus accumbens

The effects of cholecystokinin octapeptide (CCK8) on extracellular dopamine (DA) and its metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid, were measured in the nucleus accumbens (N. Acc.). The experiments were carried out using in vivo microdialysis in awake rats submitted, or not, to a novel environment, the four-hole box. The exploratory behavior of the animals was studied concurrently in these boxes and in the elevated plus maze. Without CCK8 treatment, the transfer of animals from their home cages to the four-hole box induced a transient increase in DA efflux and also tended to increase its metabolites in the posterior N. Acc. In rats placed in a familiar environment, the administration of 25 pmol of CCK8 in this region immediately enhanced DA release, with levels rapidly returning to normal at the end of the perfusion. In contrast, this treatment produced a longer effect in rats transferred to the four-hole box, since the DA efflux was still increased 80 min after the removal of CCK8. The intra-accumbal administration of CCK8 induced a hypoexploration in the four-hole box. Moreover, an anxiogenic-like effect of CCK8 was found in the elevated plus maze, only in rats submitted to a novel environment (four-hole box). These data show that (1) the postero-accumbens DA neurons can be activated by environmental changes and (2) that the intensity of the CCK8 effects on extracellular DA levels and on anxiety-like responses seems to depend on the activity of these neurons previous to CCK8 treatment. The prolonged DA release induced by CCK8 in animals placed in a new situation could correspond to a biochemical anticipation preparing them to react when faced by another stimulus.
The neurology of eye movements

The Neurology of Eye Movements, Edition 5, by R. John Leigh, M.D. and David S. Zee MD Foreword Chapter 1: A Survey of Eye Movements: Characteristics and Teleology Chapter 2: The Ocular Motor Periphery Chapter 3: The Vestibular-Optokinetic System Chapter 4: The Saccadic System Chapter 5: Smooth Visual Tracking and Fixation Chapter 6: Gaze Holding and The Neural Integrator Chapter 7: The Neural Basis for Conjugate Eye Movements Chapter 8: Eye-Head Movements Chapter 9: Vergence Eye Movements Chapter 10: Diagnosis of Peripheral Ocular Motor Palsies And Strabismus Chapter 11: Diagnosis of Nystagmus and Saccadic Intrusions Chapter 12: Diagnosis and Management of Vestibular Disorders Chapter 13: Disorders of Ocular Motility Due To Disease of the Brainstem, Cerebellum and Diencephalon Chapter 14: Disorders of Ocular Motility With Disease Affecting The Basal Ganglia, Cerebral Cortex, And In Systemic Conditions Appendix A: A Summary Scheme for the Bedside Ocular Motor Examination Appendix B: A Summary of Methods for Measuring Eye Movements Appendix C: Tables of Ocular Motor Findings in Hereditary Ataxias Appendix D: Table of Videos and their Legends
School Belonging, Educational Aspirations, and Academic Self-Efficacy among African American Male High School Students: Implications for School Counselors

While academic self-efficacy is widely considered an individual cognitive variable, it may be influenced by a sense of belonging and connection to others in the school community. Using a correlation and multiple regression design, the study in this article examined the relationship between perceptions of school belonging, educational aspirations, and academic self-efficacy among 40 African American male high school students. Results indicated that feeling encouraged to participate and educational aspirations were significant, positive predictors of academic self-efficacy. Other components of perceptions of school belonging were not significant in predicting academic self-efficacy. Recommendations for future research and practical suggestions for school counselors are discussed.
A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts

The prompt identification of chemical molecules with potential effects on liver may help in drug discovery and in raising the levels of protection for human health. Besides in vitro approaches, computational methods in toxicology are drawing attention. We built a structure-activity relationship (SAR) model for evaluating hepatotoxicity. After compiling a data set of 950 compounds using data from the literature, we randomly split it into training (80%) and test sets (20%). We also compiled an external validation set (101 compounds) for evaluating the performance of the model. To extract structural alerts (SAs) related to hepatotoxicity and non-hepatotoxicity we used SARpy, a statistical application that automatically identifies and extracts chemical fragments related to a specific activity. We also applied the chemical grouping approach for manually identifying other SAs. We calculated accuracy, specificity, sensitivity and Matthews correlation coefficient (MCC) on the training, test and external validation sets. Considering the complexity of the endpoint, the model performed well. In the training, test and external validation sets the accuracy was respectively 81, 63, and 68%, specificity 89, 33, and 33%, sensitivity 93, 88, and 80% and MCC 0.63, 0.27, and 0.13. Since it is preferable to overestimate hepatotoxicity rather than not to recognize unsafe compounds, the model's architecture followed a conservative approach. As it was built using human data, it might be applied without any need for extrapolation from other species. This model will be freely available in the VEGA platform.
Inhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oils.

A single 2-mg dose of garlic oil applied 30 minutes before a single carcinogenic dose of 7,12-dimethylbenz[a]-anthracene (DMBA) inhibited papilloma production in Sencar mice. The three groups were controls (Group 1), garlic oil applied 30 minutes before DMBA (Group 2), and garlic oil applied 30 minutes after DMBA (Group 3). The percents of mice with papillomas at 20 weeks were 94, 72, and 79, respectively. The decreases in Groups 2 and 3 were significant. The number of papillomas per mouse was 4.2 +/- 0.5 (Group 1), 2.3 +/- 0.8 (Group 2), and 3.4 +/- 0.6 (Group 3). The decrease in Group 2 was significant. A single 5-mg dose of garlic oil maximally inhibited DMBA-induced epidermal DNA synthesis by 86% when applied two hours before the carcinogen. Two-stage promotion in DMBA-initiated Sencar mice was achieved by twice-weekly applications of 8.5 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) for 2 weeks followed by twice-weekly applications of 8.5 nmol of mezerein for 18 weeks. The oils were applied 30 minutes after each promotion by TPA or mezerein. Single doses of 1 mg onion or garlic oil inhibited the first and second stages of promotion. The groups used were control (Group 1), garlic oil applied after stage 1 (Group 2), onion oil applied after stage 1 (Group 3), propenyl sulfide applied after stage 1 (Group 4), garlic oil applied after stage 2 (Group 5), onion oil applied after stage 2 (Group 6), and propenyl sulfide applied after stage 2 (Group 7). The percent of mice with papillomas was significantly decreased by all agents in Groups 2-7. The data are 81, 83, 91, 68, 96, and 86, respectively. The number of papillomas per mouse was significantly reduced by onion and garlic oils but not by propenyl sulfide. The data are 9.4 +/- 0.8, 6.3 +/- 0.7, 7.4 +/- 0.5, 9.2 +/- 1.2, 3.7 +/- 0.9, 6.2 +/- 0.6, and 9.1 +/- 1.4 for Groups 1-7, respectively. Onion and garlic oils inhibited the TPA-stimulated DNA synthesis when given as single doses of 5 mg one hour before TPA. The inhibition by garlic oil was most effective when given one hour before TPA but was evident when given from two hours before to two hours after TPA. These results, and those of others (AS Sadhana, Cancer Lett, 40, 193-197, 1988), who obtained inhibition of initiation, indicate that onion and garlic oils inhibit all stages of mouse skin tumorigenesis. (ABSTRACT TRUNCATED AT 400 WORDS)
Deep ocean nutrients imply large latitudinal variation in particle transfer efficiency

Significance Organic particles that sink to the deep ocean release carbon dioxide in waters that remain out of contact with the atmosphere on long timescales. This paper reconstructs particle flux profiles from large-scale ocean nutrient distributions, revealing systematic regional variations that have proved difficult to detect from direct observations alone. We show that the “transfer efficiency” of organic matter to depth is greatest in high-latitude regions and lowest in the subtropics, and is well explained by variations in phytoplankton community structure. These results suggest a greater sensitivity of atmospheric CO2 to high-latitude carbon export, and predict reduced ocean carbon storage as subtropical communities expand in response to climate warming. The “transfer efficiency” of sinking organic particles through the mesopelagic zone and into the deep ocean is a critical determinant of the atmosphere−ocean partition of carbon dioxide (CO2). Our ability to detect large-scale spatial variations in transfer efficiency is limited by the scarcity and uncertainties of particle flux data. Here we reconstruct deep ocean particle fluxes by diagnosing the rate of nutrient accumulation along transport pathways in a data-constrained ocean circulation model. Combined with estimates of organic matter export from the surface, these diagnosed fluxes reveal a global pattern of transfer efficiency to 1,000 m that is high (∼25%) at high latitudes and low (∼5%) in subtropical gyres, with intermediate values in the tropics. This pattern is well correlated with spatial variations in phytoplankton community structure and the export of ballast minerals, which control the size and density of sinking particles. These findings accentuate the importance of high-latitude oceans in sequestering carbon over long timescales, and highlight potential impacts on remineralization depth as phytoplankton communities respond to a warming climate.