Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics of Innovators Adopting a National Personal Health Record in Portugal: Cross-Sectional Study

Background Personal health records (PHRs) are increasingly being deployed worldwide, but their rates of adoption by patients vary widely across countries and health systems. Five main categories of adopters are usually considered when evaluating the diffusion of innovations: innovators, early adopters, early majority, late majority, and laggards. Objective We aimed to evaluate adoption of the Portuguese PHR 3 months after its release, as well as characterize the individuals who registered and used the system during that period (the innovators). Methods We conducted a cross-sectional study. Users and nonusers were defined based on their input, or not, of health-related information into the PHR. Users of the PHR were compared with nonusers regarding demographic and clinical variables. Users were further characterized according to their intensity of information input: single input (one single piece of health-related information recorded) and multiple inputs. Multivariate logistic regression was used to model the probability of being in the multiple inputs group. ArcGis (ESRI, Redlands, CA, USA) was used to create maps of the proportion of PHR registrations by region and district. Results The number of registered individuals was 109,619 (66,408/109,619, 60.58% women; mean age: 44.7 years, standard deviation [SD] 18.1 years). The highest proportion of registrations was observed for those aged between 30 and 39 years (25,810/109,619, 23.55%). Furthermore, 16.88% (18,504/109,619) of registered individuals were considered users and 83.12% (91,115/109,619) nonusers. Among PHR users, 32.18% (5955/18,504) engaged in single input and 67.82% (12,549/18,504) in multiple inputs. Younger individuals and male users had higher odds of engaging in multiple inputs (odds ratio for male individuals 1.32, CI 1.19-1.48). Geographic analysis revealed higher proportions of PHR adoption in urban centers when compared with rural noncoastal districts. Conclusions Approximately 1% of the country’s population registered during the first 3 months of the Portuguese PHR. Registered individuals were more frequently female aged between 30 and 39 years. There is evidence of a geographic gap in the adoption of the Portuguese PHR, with higher proportions of adopters in urban centers than in rural noncoastal districts.
Running head: REDUCUING FALLS WITH HOURLY ROUNDING 1 Reducing Falls with Hourly Rounding

Purpose: To explore if hourly rounding would help reduce the number of falls in adult hospitalized patients. Rationale: Approximately 700,000 to 1,000,000 hospitalized patients fall each year in the United States. A fall could result in lacerations or a fractured hip which has a financial effect on hospitals and increases a patient’s stay and the well-being of the patient. Methods: A literature review was conducted to identify the evidence-based research regarding hourly rounding and reduced number of falls. Results: The literature review showed that hourly rounding had a positive effect on the number of falls in patients who are hospitalized which in turn reduced the number of falls. The literature reviews also recommended addressing patient’s needs by asking the four “P’s”: pain, potty, positioning, and possessions. The reviews also suggested that all patients be rounded on for the first 72 hours and reassessed to determine if hourly rounding was still necessary. Implications: Skagit Valley Hospital is currently upgrading the charting system to EPIC and switching to Morse Falls Scale Assessment to determine a patient’s fall risk, this is the ideal time to educate staff on hourly rounding, introduce the four “P’s”, and hold staff accountable for rounding on patients who are at the highest risk of falls. REDUCING FALLS WITH HOURLY ROUNDING 3 Reducing Falls with Hourly Rounding
What We Observe Is Biased by What Other People Tell Us: Beliefs about the Reliability of Gaze Behavior Modulate Attentional Orienting to Gaze Cues

For effective social interactions with other people, information about the physical environment must be integrated with information about the interaction partner. In order to achieve this, processing of social information is guided by two components: a bottom-up mechanism reflexively triggered by stimulus-related information in the social scene and a top-down mechanism activated by task-related context information. In the present study, we investigated whether these components interact during attentional orienting to gaze direction. In particular, we examined whether the spatial specificity of gaze cueing is modulated by expectations about the reliability of gaze behavior. Expectations were either induced by instruction or could be derived from experience with displayed gaze behavior. Spatially specific cueing effects were observed with highly predictive gaze cues, but also when participants merely believed that actually non-predictive cues were highly predictive. Conversely, cueing effects for the whole gazed-at hemifield were observed with non-predictive gaze cues, and spatially specific cueing effects were attenuated when actually predictive gaze cues were believed to be non-predictive. This pattern indicates that (i) information about cue predictivity gained from sampling gaze behavior across social episodes can be incorporated in the attentional orienting to social cues, and that (ii) beliefs about gaze behavior modulate attentional orienting to gaze direction even when they contradict information available from social episodes.
Inhibition of CD147 (Cluster of Differentiation 147) Ameliorates Acute Ischemic Stroke in Mice by Reducing Thromboinflammation

Background and Purpose— Inflammation and thrombosis currently are recognized as critical contributors to the pathogenesis of ischemic stroke. CD147 (cluster of differentiation 147), also known as extracellular matrix metalloproteinase inducer, can function as a key mediator of inflammatory and immune responses. CD147 expression is increased in the brain after cerebral ischemia, but its role in the pathogenesis of ischemic stroke remains unknown. In this study, we show that CD147 acts as a key player in ischemic stroke by driving thrombotic and inflammatory responses. Methods— Focal cerebral ischemia was induced in C57BL/6 mice by a 60-minute transient middle cerebral artery occlusion. Animals were treated with anti-CD147 function–blocking antibody (&agr;CD147) or isotype control antibody. Blood–brain barrier permeability, thrombus formation, and microvascular patency were assessed 24 hours after ischemia. Infarct size, neurological deficits, and inflammatory cells invaded in the brain were assessed 72 hours after ischemia. Results— CD147 expression was rapidly increased in ischemic brain endothelium after transient middle cerebral artery occlusion. Inhibition of CD147 reduced infarct size and improved functional outcome on day 3 after transient middle cerebral artery occlusion. The neuroprotective effects were associated with (1) prevented blood–brain barrier damage, (2) decreased intravascular fibrin and platelet deposition, which in turn reduced thrombosis and increased cerebral perfusion, and (3) reduced brain inflammatory cell infiltration. The underlying mechanism may include reduced NF-&kgr;B (nuclear factor &kgr;B) activation, MMP-9 (matrix metalloproteinase-9) activity, and PAI-1 (plasminogen activator inhibitor-1) expression in brain microvascular endothelial cells. Conclusions— Inhibition of CD147 ameliorates acute ischemic stroke by reducing thromboinflammation. CD147 might represent a novel and promising therapeutic target for ischemic stroke and possibly other thromboinflammatory disorders.
Treatment of hepatocellular carcinoma with portal vein tumor thrombus: advances and challenges

Portal vein tumor thrombus is a frequent, challenging complication in hepatocellular carcinoma. Hepatocellular carcinoma patients with portal vein tumor thrombus may show worse liver function, less treatment tolerance and worse prognosis than patients without portal vein tumor thrombus, and they may be at higher risk of comorbidity related to portal hypertension. Western and some Asian guidelines stratify hepatocellular carcinoma with portal vein tumor thrombus together with metastatic hepatocellular carcinoma and therefore recommend only palliative treatment with sorafenib or other systemic agents. In recent years, more treatment options have become available for hepatocellular carcinoma patients with portal vein tumor thrombus, and an evidence-based approach to optimizing disease management and treatment has become more widespread. Nevertheless, consensus policies for managing hepatocellular carcinoma with portal vein tumor thrombus have not been established. This comprehensive literature review, drawing primarily on studies published after 2010, examines currently available management options for patients with hepatocellular carcinoma and portal vein tumor thrombus.
Cellular correlates of selfish spermatogonial selection†

The mechanisms leading to increased genetic risks for offspring of older fathers have received increased scrutiny with improvements in genomics technologies. For example, there is now convincing genetic evidence that, aside from the approximately linear increase in paternally originating point mutations with age (Kong et al., 2012; Rahbari et al., 2016), there is a steeper age rise for a small subset of mutations conferring gain‐of‐function properties. This is best documented for mutations in the FGFR2, FGFR3, HRAS, PTPN11 and RET genes, all of which act in growth factor receptor‐RAS signalling, a pathway known to be active in spermatogonia and that is commonly dysregulated in cancer (reviewed by Goriely & Wilkie, 2012). The mutations are proposed to provide a selective advantage for proliferation and/or survival to mutant spermatogonia (Goriely et al. 2003), leading to clonal expansion over time: a process that we have termed selfish spermatogonial selection.
Osteoblast–osteoclast interactions

ABSTRACT Bone homeostasis depends on the resorption of bones by osteoclasts and formation of bones by the osteoblasts. Imbalance of this tightly coupled process can cause diseases such as osteoporosis. Thus, the mechanisms that regulate communication between osteoclasts and osteoblasts are critical to bone cell biology. It has been shown that osteoblasts and osteoclasts can communicate with each other through direct cell–cell contact, cytokines, and extracellular matrix interaction. Osteoblasts can affect osteoclast formation, differentiation, or apoptosis through several pathways, such as OPG/RANKL/RANK, RANKL/LGR4/RANK, Ephrin2/ephB4, and Fas/FasL pathways. Conversely, osteoclasts also influence formation of bones by osteoblasts via the d2 isoform of the vacuolar (H+) ATPase (v-ATPase) V0 domain (Atp6v0d2), complement component 3a, semaphorin 4D or microRNAs. In addition, cytokines released from the resorbed bone matrix, such as TGF-β and IGF-1, also affect the activity of osteoblasts. Drugs could be developed by enhancing or restricting some of these interactions. Several reviews have been performed on the osteoblast–osteoclast communication. However, few reviews have shown the research advances in the recent years. In this review, we summarized the current knowledge on osteoblast–osteoclast communication.
Comparing watchful waiting with antidepressants for the management of subclinical depression symptoms to mild–moderate depression in primary care: a systematic review

Background The benefits of watchful waiting (WW) over antidepressants (ADs) for the treatment of depression in primary care (PC) are unclear. Objective We aimed to systematically review the evidence supporting either WW or ADs for the treatment of subclinical depressive symptoms and mild-moderate depression in a PC setting. Methods This systematic review was registered at PROSPERO (42016036345). Four electronic sources (EMBASE, PubMed, PsycINFO, Web of Knowledge) were systematically searched from inception to November 2016 for controlled trials comparing WW and ADs in PC following established guidelines. The studies had to include adult population with new symptoms of subclinical depression or mild-moderate depression. Patients in the intervention group should receive a WW approach, while patients in the control group underwent treatment with ADs. The abstraction form included information on the setting, characteristics of the study population, total sample size, size of the control and intervention groups and date of the study. Outcome measures and variability were extracted. Results The scarcity of studies and the considerable clinical and methodological heterogeneity discouraged us from performing a meta-analysis. Three articles were included and qualitatively synthesized. There was no evidence for the superiority of one treatment option over the other, although two of the studies suggested small differences in favour of ADs when less conservative analyses were conducted (per protocol analysis and analysis not adjusted for missingness predictors). Conclusions Superiority was not demonstrated by either treatment option. More robust evidence is needed to inform recommendations for the management of depressive symptoms in PC.
Applications of Generalizability Theory and Their Relations to Classical Test Theory and Structural Equation Modeling

Although widely recognized as a comprehensive framework for representing score reliability, generalizability theory (G-theory), despite its potential benefits, has been used sparingly in reporting of results for measures of individual differences. In this article, we highlight many valuable ways that G-theory can be used to quantify, evaluate, and improve psychometric properties of scores. Our illustrations encompass assessment of overall reliability, percentages of score variation accounted for by individual sources of measurement error, dependability of cut-scores for decision making, estimation of reliability and dependability for changes made to measurement procedures, disattenuation of validity coefficients for measurement error, and linkages of G-theory with classical test theory and structural equation modeling. We also identify computer packages for performing G-theory analyses, most of which can be obtained free of charge, and describe how they compare with regard to data input requirements, ease of use, complexity of designs supported, and output produced.
Ambient air pollution and stroke.

Stroke is a leading cause of death in the United States1 and worldwide (http://www.who.int) and may lead to considerable neurological sequelae including aphasia, paraplegia, and dementia. The estimated healthcare costs of stroke in the United States exceed $36 billion per year.1 A large body of evidence supports the association between ambient air pollution exposure and increased cardiovascular mortality and morbidity,2 but only recently have several studies specifically demonstrated an association with increased stroke risk. Major sources of air pollution include traffic, power plants and in developing countries, biomass combustion. Both particles and gases are emitted through combustion. Particulate matter with aerodynamic diameter <10 μm (PM10) include ultrafine particles (PM1.0), fine particles (PM2.5), and coarse particles (PM10–2.5). Ultrafine particles are emitted in fresh exhaust and coalesce into PM2.5 within a short time frame. PM2.5 includes both local sources from traffic emissions and domestic heating and regional sources from power plants, biogenic emissions, and traffic, whereas coarse particles are a heterogeneous mixture that include road dust, endotoxins, and suspended crustal matter. CO, NO2, NOx, SO2, and ground-level ozone (O3) are gaseous pollutants emitted as a result of combustion processes. CO is mainly attributed to mobile sources in urban environments, and NO2 and NOx are rapidly formed in emissions from combustion sources such as traffic and power plants. The main source of SO2 is from fossil fuel power plants. Ground-level O3 is formed as a result of atmospheric reactions of NO2 with hydrocarbons in the presence of sunlight and is a major constituent of photochemical smog. Several of the mentioned pollutants are regulated based on evidence of adverse health effects.3 Possible mechanistic pathways including induction of oxidative stress, inflammation, atherosclerosis, and …
Skeletal muscle bioenergetics during all-out exercise: mechanistic insight into the oxygen uptake slow component and neuromuscular fatigue.

Although all-out exercise protocols are commonly used, the physiological mechanisms underlying all-out exercise performance are still unclear, and an in-depth assessment of skeletal muscle bioenergetics is lacking. Therefore, phosphorus magnetic resonance spectroscopy (31P-MRS) was utilized to assess skeletal muscle bioenergetics during a 5-min all-out intermittent isometric knee-extensor protocol in eight healthy men. Metabolic perturbation, adenosine triphosphate (ATP) synthesis rates, ATP cost of contraction, and mitochondrial capacity were determined from intramuscular concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), diprotonated phosphate ([Formula: see text]), and pH. Peripheral fatigue was determined by exercise-induced alterations in potentiated quadriceps twitch force (Qtw) evoked by supramaximal electrical femoral nerve stimulation. The oxidative ATP synthesis rate (ATPOX) attained and then maintained peak values throughout the protocol, despite an ~63% decrease in quadriceps maximal force production. ThusATPOX normalized to force production (ATPOX gain) significantly increased throughout the exercise (1st min: 0.02 ± 0.01, 5th min: 0.04 ± 0.01 mM·min-1·N-1), as did the ATP cost of contraction (1st min: 0.048 ± 0.019, 5th min: 0.052 ± 0.015 mM·min-1·N-1). Additionally, the pre- to postexercise change in Qtw (-52 ± 26%) was significantly correlated with the exercise-induced change in intramuscular pH (r = 0.75) and [Formula: see text] concentration (r = 0.77). In conclusion, the all-out exercise protocol utilized in the present study elicited a "slow component-like" increase in intramuscular ATPOX gain as well as a progressive increase in the phosphate cost of contraction. Furthermore, the development of peripheral fatigue was closely related to the perturbation of specific fatigue-inducing intramuscular factors (i.e., pH and [Formula: see text] concentration). NEW & NOTEWORTHY The physiological mechanisms and skeletal muscle bioenergetics underlying all-out exercise performance are unclear. This study revealed an increase in oxidative ATP synthesis rate gain and the ATP cost of contraction during all-out exercise. Furthermore, peripheral fatigue was related to the perturbation in pH and deprotonated phosphate ion. These findings support the concept that the oxygen uptake slow component arises from within active skeletal muscle and that skeletal muscle force generating capacity is linked to the intramuscular metabolic milieu.
Modulation and coding for the Gaussian collision channel

We study signal-space coding for coherent slow frequency-hopped communications over a Gaussian multiple-access collision channel (G-MACC). We define signal sets and interleavers having maximum collision resistance. The packet-error probability and the spectral efficiency obtained by these signal sets concatenated with outer block coding and hard (error-only) decoding is evaluated without assuming perfect interleaving. Closed-form expressions are provided and computer simulations show perfect agreement with analysis. The structure of good interleavers is also discussed. More generally, we present expressions for the information outage probability and for the achievable (ergodic) rate of the G-MACC at hand, under various assumptions on user coding and decoding strategies. The outage probability yields the limiting packet-error probability with finite interleaving depth (delay-limited systems). The achievable rate yields the limiting system spectral efficiency for large interleaving depth (delay-unconstrained systems). Comparisons with other classical multiple-access schemes are provided.
Public Sound Objects: a shared environment for networked music practice on the Web

The Public Sound Objects (PSOs) project consists of the development of a networked musical system, which is an experimental framework to implement and test new concepts for online music communication. The PSOs project approaches the idea of collaborative musical performances over the Internet by aiming to go beyond the concept of using computer networks as a channel to connect performing spaces. This is achieved by exploring the internet's shared nature in order to provide a public musical space where anonymous users can meet and be found performing in collective sonic art pieces. The system itself is an interface-decoupled musical instrument, in which a remote user interface and a sound processing engine reside with different hosts in an extreme scenario where a user can access the synthesizer from any place in the world using the World Wide Web. Specific software features were implemented in order to reduce the disruptive effects of network latency, such as dynamic adaptation of the musical tempo to communication latency measured in real time and consistent sound panning with the object's behaviour at the graphical user interface.
Geospatial analysis of controls on subglacial bedform morphometry in the New York Drumlin Field – implications for Laurentide Ice Sheet dynamics

The outline and trend of 6566 subglacial bedforms in the New York Drumlin Field have been digitized from digital elevation data. A spatial predictive model has been used to extend values of bedform elongation over an area measuring 200 km × 110 km. The resulting surface is used in conjunction with depth‐to‐bedrock data and an assumed duration of ice residence to test three proposed controls on bedform elongation. Upon comparison, the resulting display of morphometry is best explained by differences in ice velocity across the field of study. The existence of multiple zones of fast‐moving ice located along the southern margin of the Laurentide Ice Sheet is implied by the observed patterns of bedform elongation and orientation. We present two interpretations that are consistent with the observations. First, enhanced basal sliding caused by decreasing effective pressure near a calving margin is suggested as a possible mechanism by which localized fast ice flow is initiated and maintained. Second, topographically controlled ice streams likely occupied the fjord‐like troughs of the Appalachian Upland northern rim. Contrary to previous understanding of the Laurentide southern margin in New York State, the resulting palaeoglaciological reconstruction illustrates a dynamic mosaic of ice stream and/or outlet glacier activity. Copyright © 2009 John Wiley & Sons, Ltd.