Miracle-dz/UniFAR-FTUs huggingface dataset:
PGC-1α Downregulation in Steatotic Liver Enhances Ischemia-Reperfusion Injury and Impairs Ischemic Preconditioning.

AIMS Liver steatosis is associated with mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels together with enhanced sensitivity to ischemia-reperfusion (IR) injury and limited response to preconditioning protocols. Here, we sought to determine whether the downregulation in the steatotic liver of peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α), a master regulator of mitochondrial metabolism and ROS that is known to play a role in liver metabolic control, could be responsible for the sensitivity of the steatotic liver to ischemic damage. RESULTS PGC-1α was induced in normal liver after exposure to an IR protocol, which was concomitant with an increase in the levels of antioxidant proteins. By contrast, its induction was severely blunted in the steatotic liver, resulting in a modest induction of antioxidant proteins. Livers of PGC-1α-/- mice on a chow diet were normal, but they exhibited an enhanced sensitivity to IR injury and also a lack of response to ischemic preconditioning (IPC), a phenotype that recapitulated the features of the steatotic liver in terms of liver damage, although the inflammatory response differed between both models. Utilizing an in vitro model of IPC, we found that PGC-1α expression was downregulated in hepatic cells cultured at 1% O2; whereas it was induced after reoxygenation (3% O2), and it was responsible for the recovery of antioxidant gene expression after the ischemic period. Innovation & Conclusion: PGC-1α plays an important role in the protection against IR injury in the liver, which is likely associated with its capacity to induce antioxidant gene expression. Antioxid. Redox Signal. 27, 1332-1346.
Coexistence of celiac disease & type 1 diabetes mellitus in children

Background & objectives: Type 1 diabetes mellitus (T1DM) and celiac disease (CD) tend to co-exist due to similar underlying genetic predisposition. Failure to recognize CD in patients with T1DM predisposes them to complications. The present study was aimed to assess children with T1DM for the presence of CD. Methods: This was a retrospective analysis of the records of children with T1DM attending paediatric endocrinology clinic at a tertiary care hospital in north India from January 2006 to May 2014. All children were screened for CD at the time of diagnosis of T1DM using IgA anti-tissue transglutaminase (anti-tTG) levels in serum. Seropositive children were subjected to upper gastrointestinal endoscopy and duodenal biopsy for histopathological confirmation. The children also underwent thyroid function testing (TFT); those with deranged TFT were evaluated for thyroid-specific antibodies. Results: Positive serology for CD was present in 43 of 126 children with T1DM whose records were reviewed [34.1%; 95% confidence interval (CI): 25.9-43.1]. Confirmed CD was diagnosed in 17 (13.5%; CI: 8.1-20.7) of the children screened and 17 of 40 (42.5%; CI: 27.1-59.1) seropositive participants. Four out of 17 children with coexisting CD and T1DM also had autoimmune thyroiditis with overt hypothyroidism. The children with confirmed CD were more likely to have short stature [odds ratios (OR)-3.16; 95% CI: 1.09-9.20, P<0.05] and hypothyroidism (OR-6.4; 95% CI: 1.52-26.90, P<0.05). Interpretation & conclusions: Our study showed a higher proportion of CD in children with T1DM as compared to that reported in general population. Regular screening of children with T1DM for CD is needed to improve metabolic control and prevent long-term complications.
Piloting and psychometric properties of a patient-reported outcome instrument for young people with achondroplasia based on the International Classification of Functioning Disability and Health: the Achondroplasia Personal Life Experience Scale (APLES)

Abstract Background: This study describes the psychometric testing of the Achondroplasia Personal Life Experience Scale (APLES): a new disease- and functioning-specific health-related quality of life instrument for young people with achondroplasia, which was developed based on the International Classification of Functioning–Children and Youth Version. Method: The qualitative analysis of focus group statements from German patients and parents using the International Classification of Functioning–Children and Youth Version yielded 59 items, which after cognitive debriefing were included in a pilot-test. Psychometric performance was cross-culturally examined in a field- and re-test in Germany and Spain. Results: Cognitive debriefing and pilot-test results suggested to reduce the 59-APLES version to a 35-items version. Field-test data showed acceptable reliability and validity, which further improved after the APLES was shortened to 21 items. Conclusion: Developing a disease-specific instrument within the framework of the International Classification of Functioning allows the universal assessment and comparison of perceived health. Psychometric analysis showed that the APLES fulfills psychometric quality standards and provides a way to assess health-related quality of life from self- and observer report in young persons with achondroplasia. Further studies may use the instrument in clinical research and practice to understand perceived burden and to optimize care. Implications for Rehabilitation Health-related quality of life instruments are useful tools to include in clinical research and/or practice to evaluate treatment effects directly from the patient’s perspective. Cross-culturally developed health-related quality of life measures that are based on the International Classification of Functioning Disability and Health provide the opportunity to assess the health status in a standardized language and to compare it across countries and health professions. All four components of the International Classification of Functioning Disability and Health – Child and Youth Version (“Body Functions & Structures”, “Activities and Participation”, “Environmental Factors”, and “Personal Factors”) have been shown to be relevant in assessing health-related quality of life and functioning in young achondroplasia patients. Results underline the important aspects associated with disproportionate short stature, emphasizing the benefits of a disease-specific instrument.
Predicting Rape Victim Empathy Based on Rape Victimization and Acknowledgment Labeling

Two studies examined rape victim empathy based on personal rape victimization and acknowledgment labeling. Female undergraduates (Study 1, n = 267; Study 2, n = 381) from a Northeast U.S. midsize public university completed the Rape-Victim Empathy Scale and Sexual Experiences Survey. As predicted, both studies found that acknowledged “rape” victims reported greater empathy than unacknowledged victims and nonvictims. Unexpectedly, these latter two groups did not differ. Study 1 also found that acknowledged “rape” victims reported greater empathy than victims who acknowledged being “sexually victimized. ” Findings suggest that being raped and acknowledging “rape” together may facilitate rape victim empathy.
Effects of rates and nitrogen application timing on yield, agronomic characteristics and nitrogen use efficiency in corn.

In order to study effects of rates and nitrogen application timing on yield, agronomic characteristics and nitrogen use efficiency in corn, an experiment was conducted as split plot based on randomized complete block design with three replications at the Research Farm of University of Mohaghegh Ardabili during 2009 cropping season. Nitrogen rates were arranged in main plot with four levels including: 0, 75, 150 and 225 Kg N.ha -1 and nitrogen application timing in sub plots by three levels including: ( 1 /3 in planting + 1 /3 in 8-10 leaf stages + 1 /3 in tasseling initation ), ( ½ planting + ½ in tasseling initiation) and (½ in planting + ¼ in 8-10 leaf stages + ¼ in tasseling initation) as T1, T2 and T3 respectively. Results indicated that qualitative and quantitative yield, agronomic characterstics and nitrogen use efficiency were significantly affected by rates, N application timing and interaction of rates × N application timing. The highest the number of grain per ear, the number of grains per ear row and grain yield at the highest rates of nitrogen fertilizer with N application timing as T1. The number of grain row did not affected by rates of nitrogen fertilizer and N application timing. The highest grain yield (7928.6 Kg.ha -1 ) belonged to treatment combination of 225 Kg N.ha -1 with N application timing as T1. The effect of treatment combination of rates ×N application timing was significant on fertilizer use efficiency. Maximum nitrogen use efficiency (38.16 kg/kg) was obtained in treatment compounds which 75 Kg N.ha -1 as T1 was applied and minimum of it (19.41 kg/kg) was obtained in the treatment compounds which 225 Kg N.ha -1 as T2 was applied. Thus, it is suggested that in order to increasing of qualitative and quantitative yield and some agronomic characterstics such as plant height, cob length and diameter should be applied 225 Kg N.ha -1 as T1. But for increasing of nitrogen use efficiency can be suggested that 75 Kg N.ha -1 as T1 should be applied in conditions of experiment.
Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment

Background Gemcitabine (GEM) is widely used as an anticancer agent in several types of solid tumors. Silver nanoparticles (AgNPs) possess unique cytotoxic features and can induce apoptosis in a variety of cancer cells. In this study, we investigated whether the combination of GEM and AgNPs can exert synergistic cytotoxic effects in the human ovarian cancer cell line A2780. Methods We synthesized AgNPs using resveratrol as a reducing and stabilizing agent. The synthesized nanomaterials were characterized using various analytical techniques. The anticancer effects of a combined treatment with GEM and AgNPs were evaluated using a series of cellular assays. The expression of pro- and antiapoptotic genes was measured using real-time reverse transcription polymerase chain reaction. Apoptosis was confirmed by TUNEL assay. Results In this study, combined treatment with GEM and AgNPs significantly inhibited viability and proliferation in A2780 cells. Moreover, the levels of apoptosis in cells treated with a combination of GEM and AgNPs were significantly higher compared with those in cells treated with GEM or AgNPs alone. Our data suggest that GEM and AgNPs exhibit potent apoptotic activity in human ovarian cancer cells. Combined treatment with GEM and AgNPs showed a significantly higher cytotoxic effect in ovarian cancer cells compared with that induced by either of these agents alone. Conclusion Our study demonstrated that the interaction between GEM and AgNPs was cytotoxic in ovarian cancer cells. Combined treatment with GEM and AgNPs caused increased cytotoxicity and apoptosis in A2780 cells. This treatment may have therapeutic potential as targeted therapy for the treatment of ovarian cancer. To our knowledge, this study could provide evidence that AgNPs can enhance responsiveness to GEM in ovarian cancer cells and that AgNPs can potentially be used as chemosensitizing agents in ovarian cancer therapy.
Marine exotic isopods from the Iberian Peninsula and nearby waters

Effective management of marine bioinvasions starts with prevention, communication among the scientific community and comprehensive updated data on the distribution ranges of exotic species. Despite being a hotspot for introduction due to numerous shipping routes converging at the Strait of Gibraltar, knowledge of marine exotics in the Iberian Peninsula is scarce, especially of abundant but small-sized and taxonomically challenging taxa such as the Order Isopoda. To fill this gap, we conducted several sampling surveys in 44 marinas and provide the first comprehensive study of marine exotic isopods from the Iberian Peninsula, the southern side of the Strait of Gibraltar (northern Africa) and the Balearic Islands. Exotic species included Ianiropsis serricaudis (first record for the Iberian Peninsula and Lusitanian marine province), Paracerceis sculpta (first record for the Alboran Sea ecoregion), Paradella dianae, Paranthura japonica (earliest record for the Iberian Peninsula) and Sphaeroma walkeri. Photographs with morphological details for identification for non-taxonomic experts are provided, their worldwide distribution is updated and patterns of invasion are discussed. We report an expansion in the distribution range of all species, especially at the Strait of Gibraltar and nearby areas. Ianiropsis serricaudis and Paranthura japonica are polyvectic, with shellfish trade and recreational boating being most probable vectors for their introduction and secondary spread. The subsequent finding of the studied species in additional marinas over the years points at recreational boating as a vector and indicates a future spread. We call for attention to reduce lags in the detection and reporting of small-size exotics, which usually remain overlooked or underestimated until the invasion process is at an advanced stage.
Impact of training status on maximal oxygen uptake criteria attainment during running

Objectives . The aims of this study were to assess whether training status influenced maximal physiological and perceptual responses and whether certain maximal criteria were more sensitive for individuals with different levels of training. Methods. Males who were either trained (N=8) or untrained (N=9) underwent a maximal treadmill test to assess whether the criteria to indicate VO2 max were training-specific. Results . VO2 max was significantly higher in the trained (70.0mlO2.kg-1.min-1) compared with the untrained group (54.5 mlO2.kg-1.min-1). Only 11% of the trained and 56% of the untrained individuals achieved a plateau in the oxygen uptake curve. Peak treadmill running speed was significantly faster and total test time significantly longer in the trained group. In contrast, peak lactate, although maximal for both groups, was significantly higher in the untrained group (13.5 mmol.l-1 compared with 10.3 mmol.l-1). The other responses were not different between the groups. Noteworthy is that none of the subjects achieved all of the criteria indicating a maximal effort. The criteria most achieved in both samples were HRmax, RPEmax and Lamax with the latter being the most attained in the untrained group and RPEmax being mostly attained by the trained group. Conclusions . The criteria used to indicate attainment of VO2 max may be limited and may differ when comparing a heterogeneous training sample. Although VO2 max was significantly higher in the trained group, responses were different for O2 plateau attainment and Lamax but similar for the other British Association of Sports Sciences criteria. It may be concluded that the physiological variables coinciding with maximal effort may differ in individuals with different levels of training.
Altruism in Forest Chimpanzees: The Case of Adoption

In recent years, extended altruism towards unrelated group members has been proposed to be a unique characteristic of human societies. Support for this proposal seemingly came from experimental studies on captive chimpanzees that showed that individuals were limited in the ways they shared or cooperated with others. This dichotomy between humans and chimpanzees was proposed to indicate an important difference between the two species, and one study concluded that “chimpanzees are indifferent to the welfare of unrelated group members”. In strong contrast with these captive studies, consistent observations of potentially altruistic behaviors in different populations of wild chimpanzees have been reported in such different domains as food sharing, regular use of coalitions, cooperative hunting and border patrolling. This begs the question of what socio-ecological factors favor the evolution of altruism. Here we report 18 cases of adoption, a highly costly behavior, of orphaned youngsters by group members in Taï forest chimpanzees. Half of the adoptions were done by males and remarkably only one of these proved to be the father. Such adoptions by adults can last for years and thus imply extensive care towards the orphans. These observations reveal that, under the appropriate socio-ecologic conditions, chimpanzees do care for the welfare of other unrelated group members and that altruism is more extensive in wild populations than was suggested by captive studies.
Assessing the Impact of Spectral Resolution on Classification of Lowland Native Grassland Communities Based on Field Spectroscopy in Tasmania, Australia

This paper presents a case study for the analysis of endangered lowland native grassland communities in the Tasmanian Midlands region using field spectroscopy and spectral convolution techniques. The aim of the study was to determine whether there was significant improvement in classification accuracy for lowland native grasslands and other vegetation communities based on hyperspectral resolution datasets over multispectral equivalents. A spectral dataset was collected using an ASD Handheld-2 spectroradiometer at Tunbridge Township Lagoon. The study then employed a k-fold cross-validation approach for repeated classification of a full hyperspectral dataset, a reduced hyperspectral dataset, and two convoluted multispectral datasets. Classification was performed on each of the four datasets a total of 30 times, based on two different class configurations. The classes analysed were Themeda triandra grassland, Danthonia/Poa grassland, Wilsonia rotundifolia/Selliera radicans, saltpan, and a simplified C3 vegetation class. The results of the classifications were then tested for statistically significant differences using ANOVA and Tukey’s post-hoc comparisons. The results of the study indicated that hyperspectral resolution provides small but statistically significant increases in classification accuracy for Themeda and Danthonia grasslands. For other classes, differences in classification accuracy for all datasets were not statistically significant. The results obtained here indicate that there is some potential for enhanced detection of major lowland native grassland community types using hyperspectral resolution datasets, and that future analysis should prioritise good performance in these classes over others. This study presents a method for identification of optimal spectral resolution across multiple datasets, and constitutes an important case study for lowland native grassland mapping in Tasmania.
Helper Data Algorithms for PUF-Based Key Generation: Overview and Analysis

Security-critical products rely on the secrecy and integrity of their cryptographic keys. This is challenging for low-cost resource-constrained embedded devices, with an attacker having physical access to the integrated circuit (IC). Physically, unclonable functions are an emerging technology in this market. They extract bits from unavoidable IC manufacturing variations, remarkably analogous to unique human fingerprints. However, post-processing by helper data algorithms (HDAs) is indispensable to meet the stringent key requirements: reproducibility, high-entropy, and control. The novelty of this paper is threefold. We are the first to provide an in-depth and comprehensive literature overview on HDAs. Second, our analysis does expose new threats regarding helper data leakage and manipulation. Third, we identify several hiatuses/open problems in existing literature.
LightGBM: A Highly Efficient Gradient Boosting Decision Tree

Gradient Boosting Decision Tree (GBDT) is a popular machine learning algorithm, and has quite a few effective implementations such as XGBoost and pGBRT. Although many engineering optimizations have been adopted in these implementations, the efficiency and scalability are still unsatisfactory when the feature dimension is high and data size is large. A major reason is that for each feature, they need to scan all the data instances to estimate the information gain of all possible split points, which is very time consuming. To tackle this problem, we propose two novel techniques: \emph{Gradient-based One-Side Sampling} (GOSS) and \emph{Exclusive Feature Bundling} (EFB). With GOSS, we exclude a significant proportion of data instances with small gradients, and only use the rest to estimate the information gain. We prove that, since the data instances with larger gradients play a more important role in the computation of information gain, GOSS can obtain quite accurate estimation of the information gain with a much smaller data size. With EFB, we bundle mutually exclusive features (i.e., they rarely take nonzero values simultaneously), to reduce the number of features. We prove that finding the optimal bundling of exclusive features is NP-hard, but a greedy algorithm can achieve quite good approximation ratio (and thus can effectively reduce the number of features without hurting the accuracy of split point determination by much). We call our new GBDT implementation with GOSS and EFB \emph{LightGBM}. Our experiments on multiple public datasets show that, LightGBM speeds up the training process of conventional GBDT by up to over 20 times while achieving almost the same accuracy.
Intracystic interferon-alpha in pediatric craniopharyngioma patients: an international multicenter assessment on behalf of SIOPE and ISPN

Background Craniopharyngiomas are frequent hypothalamo-pituitary tumors in children, presenting predominantly as cystic lesions. Morbidity from conventional treatment has focused attention on intracystic drug delivery, hypothesized to cause fewer clinical consequences. However, the efficacy of intracystic therapy remains unclear. We report the retrospective experiences of several global centers using intracystic interferon-alpha. Methods European Société Internationale d'Oncologie Pédiatrique and International Society for Pediatric Neurosurgery centers were contacted to submit a datasheet capturing pediatric patients with cystic craniopharyngiomas who had received intracystic interferon-alpha. Patient demographics, administration schedules, adverse events, and outcomes were obtained. Progression was clinical or radiological (cyst reaccumulation, novel cysts, or solid growth). Results Fifty-six children (median age, 6.3 y) from 21 international centers were identified. Median follow-up from diagnosis was 5.1 years (0.3-17.7 y). Lesions were cystic (n = 22; 39%) or cystic/solid (n = 34; 61%). Previous progression was treated in 43 (77%) patients before interferon use. In such cases, further progression was delayed by intracystic interferon compared with the preceding therapy for cystic lesions (P = 0.0005). Few significant attributable side effects were reported. Progression post interferon occurred in 42 patients (median 14 mo; 0-8 y), while the estimated median time to definitive therapy post interferon was 5.8 (1.8-9.7) years. Conclusions Intracystic interferon-alpha can delay disease progression and potentially offer a protracted time to definitive surgery or radiotherapy in pediatric cystic craniopharyngioma, yet demonstrates a favorable toxicity profile compared with other therapeutic modalities-important factors for this developing age group. A prospective, randomized international clinical trial assessment is warranted.