Miracle-dz/UniFAR-FTUs huggingface dataset:
Cytokinetic and molecular pharmacology studies of arabinosylcytosine in metastatic melanoma.

Eighteen patients with metastatic melanoma involving the skin were treated with 5-day courses of arabinosylcytosine (ara-C) every 3 weeks. Of the 13 adequately treated patients, there was 1 excellent objective response which lasted for 8 months and 2 transient partial responses. The ara-C kinase [activating enzyme (K)] and ara-C deaminase [inactivating enzyme (D)] were measured prior to treatment. The K values were higher in the responding patients, and the D values were higher in the nonresponding patients. The K/D ratio was significantly higher in the former patients, compared with that in the latter. Similarly, the proportion of tumor cells in DNA synthesis as determined from labeling indices was highest in the response group. Also, the labeling index percentage was depressed to a greater degree during therapy and remained depressed for a longer period of time after therapy in the patients who responded to treatment, when compared with those who failed to respond. For the nonresponders, recovery of DNA synthesis was complete or nearly complete by Day 21 post therapy. It is concluded from this study that ara-C is inactive in the majority of patients with melanoma, that it has greater activity in females with melanoma compared to males, and that enzyme and cytokinetic studies can be used to predict clinical response to ara-C.
Non Steroidal Anti-Inflammatory Drugs and Inflammatory Bowel Disease

Inflammatory Bowel Diseases (IBD) are an immune mediated chronic or relapsing disorders of the gastrointestinal (GI) tract. IBD is characterized by a chronic intestinal inflammatory process with various components contributing to the pathogenesis of the disease including environmental factors such as smoking or use of Non Steroidal Anti-Inflammatory Drugs (NSAIDS). NSAIDS are among the most commonly used medications for the treatment of various inflammatory conditions. The main factor limiting NSAIDS use is the concern for the development of gastrointestinal toxicity including mucosal injury. A possible association between the use of NSAIDS and the onset or relapse of IBD has been repeatedly suggested. This article will review the current concepts and evidence of the relationship between IBD and NSAIDS.
Occupational Health Hazards among Healthcare Workers in Kampala, Uganda

Objective. To assess the occupational health hazards faced by healthcare workers and the mitigation measures. Methods. We conducted a cross-sectional study utilizing quantitative data collection methods among 200 respondents who worked in 8 major health facilities in Kampala. Results. Overall, 50.0% of respondents reported experiencing an occupational health hazard. Among these, 39.5% experienced biological hazards while 31.5% experienced nonbiological hazards. Predictors for experiencing hazards included not wearing the necessary personal protective equipment (PPE), working overtime, job related pressures, and working in multiple health facilities. Control measures to mitigate hazards were availing separate areas and containers to store medical waste and provision of safety tools and equipment. Conclusion. Healthcare workers in this setting experience several hazards in their workplaces. Associated factors include not wearing all necessary protective equipment, working overtime, experiencing work related pressures, and working in multiple facilities. Interventions should be instituted to mitigate the hazards. Specifically PPE supply gaps, job related pressures, and complacence in adhering to mitigation measures should be addressed.
Steady-State Availability of k-out-of-n:G System with Single Repair

This paper presents a solution and computer program for steady-state availability of a k-out-of-n:G system with single repair. Techniques and methodologies are commonly treated in text books to solve one and two element availabilities. This paper provides both the solution for k-out-of-n system availability and a FORTRAN source program for calculating the availability. The managers of mass transit and computer systems can put n elements on line with the assurance that, on the average, at least k elements will actually be available to complete the mission.
The Eclectic Paradigm as an Envelope for Economic and Business Theories of MNE Activity: The Selected Essays of John H. Dunning, Volume I

This paper updates some of the author's thinking on the eclectic paradigm of international production, and relates it to a number of mainstream, but context-specific economic and business theories. It suggests that by dynamizing the paradigm, and widening it to embrace asset-augmenting foreign direct investment and MNE, activity it may still claim to be the dominant paradigm explaining the extent and pattern of the foreign value added activities of firms in a globalizing, knowledge intensive and alliance based market economy.
Meaningfulness, Commitment, and Engagement:The Intersection of a Deeper Level of Intrinsic Motivation

The problem and the solution. The work motivation literature suggests the existence of a level of motivation that goes beyond the commonly known typologies of intrinsic and extrinsic motivation. The purpose of this article is to explore that deeper level of intrinsic motivation, meaningfulness, and to discuss the connections between meaning of work and meaning at work, represented by the concepts of employee commitment and engagement. This multidimensional approach combines the individual and psychological aspects of work motivation with the contextual and cultural factors that influence employee motivation.
The Stem Family in Ireland

The subject of this paper is the question of the stem family, in the sociological literature and in anthropological studies of Ireland. The notion of the stem family is said to derive from the work of the nineteenth-century French sociologist Frederic Le Play (1806–82). Le Play divided the history of the family into three stages. Ancient societies were supposedly characterized by what he called the ‘patriarchal’ family, in which all the sons were retained within the household, over which the oldest member of the family ruled and in which any number of generations resided. Most of the world's population were said however to have experienced their primary socialization in the ‘stem’ family. The stem family was a threegenerational structure which functioned to retain its original location (land and/or house) by means of dispersing most younger members, while preserving the main family stem by a principle of single inheritance. Parents married off and kept within the group only those children nominated as successors. Finally, there was the modern, ‘unstable’ family which formed upon marriage and dissolved upon the death of the parents.
Learning and Teaching: A Theory of Action Perspective

This article describes learning and teaching activities in large group settings that are informed by a theory of action perspective and examines the epistemological and pedagogical implications for effective management education. The author lays out the underlying tenants of a theory of action perspective most relevant to learning and teaching, explores the implications for action and implementation in the management classroom, and illustrates a case writing process and teaching method that meets the criteria for good theory in action-based education.
Consistency in transcription and labelling of German intonation with GToBI

A diverse set of speech data was labelled in three sites by 13 transcribers with differing levels of expertise, using GToBI, a consensus transcription system for German intonation. Overall inter-transcriber-consistency suggests that, with training, labellers can acquire sufficient skill with GToBI for large-scale database labelling.
Intact Bilateral Resting-State Networks in the Absence of the Corpus Callosum

Temporal correlations between different brain regions in the resting-state BOLD signal are thought to reflect intrinsic functional brain connectivity (Biswal et al., 1995; Greicius et al., 2003; Fox et al., 2007). The functional networks identified are typically bilaterally distributed across the cerebral hemispheres, show similarity to known white matter connections (Greicius et al., 2009), and are seen even in anesthetized monkeys (Vincent et al., 2007). Yet it remains unclear how they arise. Here we tested two distinct possibilities: (1) functional networks arise largely from structural connectivity constraints, and generally require direct interactions between functionally coupled regions mediated by white-matter tracts; and (2) functional networks emerge flexibly with the development of normal cognition and behavior and can be realized in multiple structural architectures. We conducted resting-state fMRI in eight adult humans with complete agenesis of the corpus callosum (AgCC) and normal intelligence, and compared their data to those from eight healthy matched controls. We performed three main analyses: anatomical region-of-interest-based correlations to test homotopic functional connectivity, independent component analysis (ICA) to reveal functional networks with a data-driven approach, and ICA-based interhemispheric correlation analysis. Both groups showed equivalently strong homotopic BOLD correlation. Surprisingly, almost all of the group-level independent components identified in controls were observed in AgCC and were predominantly bilaterally symmetric. The results argue that a normal complement of resting-state networks and intact functional coupling between the hemispheres can emerge in the absence of the corpus callosum, favoring the second over the first possibility listed above.
Analyzing the commitment-loyalty link in service contexts

This study addressed the ill-understood issue of how loyalty develops in service patrons. Although many theorists hold commitment to be an essential part of this process, the link between commitment and loyalty has received little empirical attention. To address this void, the study first portrayed commitment’s root tendency to resist changing preference as a function of three antecedent processes. Second, this portrayal formed the basis for developing a psychometrically sound scale to measure the construct of commitment. Third, the scale was then used in a mediating effects model (M-E-M) to test the commitment-loyalty link. Path analyses found this parsimonious structure to be a significant improvement over rival direct effects models (D-E-Ms). Results found the tendency to resist changing preference to be a key precursor to loyalty, largely explained by a patron’s willingness to identify with a brand. Implications of these findings for loyalty’s development and research are explored.
Physicochemical Properties and Microbial Quality of Tremella aurantialba Packed in Antimicrobial Composite Films

The effects of poly(lactic acid) (PLA)-based film with inorganic antimicrobial nano-TiO2 and nano-Ag on the physicochemical and microbial quality of Tremella aurantialba stored at 4 ± 1 °C for 16 days was investigated. Rosemary essential oil (REO, 9 wt %) was added into PLA film as plasticizer. Low-density polyethylene (LDPE) and PLA film was used as the controls. The experiment measured physicochemical properties and microbial levels, such as weight loss, firmness, vitamin C, color, microbiological quality, and sensory quality. Although Tremella aurantialba packed by nano-composite films had the highest weight loss (4.96% and 5.17%) at the end of storage, it was still in the vicinity of 5%. Tremella aurantialba packed with nano-composite films were significantly (p < 0.05) firmer than those packed by LDPE, PLA, and PLA/REO films. The nano-composite films were more effective in reducing vitamin C and microbial counts and preserving the color of Tremella aurantialba than the other three groups. The overall acceptability of Tremella aurantialba packed by the nano-composite films still remained good and within the limits of marketability after 12 days of storage. The results suggested that the proposed nano-composite films could maintain the quality of Tremella aurantialba and extend its postharvest life.
Respiratory pattern at hospital discharge in asymptomatic preterm infants

Pneumogram (PG) recordings were performed in 87 very low birthweight (VLBW) asymptomatic infants just prior to hospital discharge to determine the relationships between: 1) a prior history of apnea of prematurity (AOP) and cardiorespiratory pattern; and 2) cardiorespiratory pattern at hospital discharge and postconceptional age. Apnea density (A6/D%) and longest apnea were significantly greater in those with (n = 66), versus without (n = 21) a prior history of AOP (P < 0.05 and P < 0.01, respectively). Although PG values for the 21 VLBW infants without a prior history of AOP did not differ significantly from those of full‐term infants, for the 66 VLBW infants with a prior AOP history A6/D% (P < 0.01), episodes of periodic breathing (P < 0.05) and longest apnea (P < 0.001) were significantly greater compared with full‐term infants. Postconceptional age was significantly less in the VLBW infants with A6/D% values above, compared with those within the 95th percentile for normal infants (median age, 36 and 37.5 weeks; P = 0.01). Therefore, respiratory pattern abnormalities in asymptomatic VLBW infants ready for hospital discharge are related to a prior history of AOP and may be significantly higher than in full‐term infants at the postconceptional ages at which hospital discharge now tends to occur.
Ovarian tissue cryopreservation: An update

Ovarian tissue cryopreservation and transplantation have been considered as promising means of fertility preservation for women who have survived cancer, with livebirths being reported from this technique. Ovarian tissue cryopreservation can be offered to patients with different types of cancer. Among the cryoprotectants, glycerol appears to give the poorest results. The techniques of cryopreserving ovarian tissue and alternative approaches have been reviewed in this article. The readers are reminded that this technique is still experimental and informed consent to be obtained from patients after counseling with medical information on the risks involved.
Autonomic-cardiorespiratory regulation: A physiology-based mathematical model

This paper presents a novel physiology-based mathematical model of autonomic-cardiorespiratory regulation described by a set of three nonlinear, coupled differential equations. We improved our previously proposed autonomic-cardiac regulation model by considering neuromechanical and mechanical coupling of cardiovascular and respiration systems including lung stretch-receptor reflex and venous return variation. We also introduced a differential equation describing respiration rate regulation which mainly originates in the medullary respiratory center. The results of simulation experiments suggest that the venous return variation generates a higher perturbation on heart rate and blood pressure than lung stretch-receptor reflex. The proposed model is also powerful in determining and removing direct respiratory impacts on parasympathetic activation tone to accurately extract parasympathetic activity caused by emotional states and environmental conditions.
Driven to abstraction: doctoral supervision and writing pedagogies

The writing of academic abstracts is more than a tiresome necessity of scholarly life. It is a practice that goes beyond genre and technique to questions of writing and identity. In this article we deconstruct a series of abstracts from a variety of refereed journals to ‘read’ for the representation of data, argument, methodology and significance. We describe one strategy for writing abstracts, developed as part of a long‐term project on postgraduate writing pedagogies. We propose that the art of writing abstracts is neglected in the academy, is given scant attention by journal editors, and has produced a motley and often bland array of conventions and genres. We suggest that abstract art should be an important aspect of supervision if graduate students and novice researchers are to stake a claim in the academy.
Interaction of Perirhinal Cortex with the Fornix–Fimbria: Memory for Objects and “Object-in-Place” Memory

Four monkeys (Macaca mulatta) were trained preoperatively in an automated object-in-place memory task in which they learned 20 new scenes in each daily session. In the object-in-place memory task, the correct, rewarded response in each scene is to a particular object of a pair, which always occupies a particular position in a unique background that has been generated using randomly chosen colors and shapes. Each animal then underwent two surgeries, with a period of testing after each. In the first, control surgery, each animal had either a unilateral lesion of the perirhinal cortex or unilateral fornix–fimbria transection, combined with section of the body and splenium of the corpus callosum and the anterior commissure (to prevent interhemispheric transfer of visual information). The disconnection was completed in the second surgery, after which all animals had a unilateral perirhinal cortex ablation in one hemisphere, unilateral fornix–fimbria transection in the contralateral hemisphere, and partial forebrain commissurotomy. The monkeys performance was compared for the learning of 200 scenes, preoperatively and after each surgery. After control surgery, the animals were mildly impaired on the object-in-place task. After disconnection, the animals showed a severe impairment in object-in-place memory. We conclude from this that, in episodic memory, the perirhinal cortex provides input of visual object information to the subiculum, hippocampus, and fornix.
The effect of change of context in Coombs' unfolding theory

Abstract An empirical investigation of Coombs' unfolding theory was conducted in which basic assumptions of the theory were tested. The primary concern was to investigate the effects upon individuals' preference judgements when the presented set of scaled stimuli was changed. Two types of judgemental tasks were used to assess these possible contextual effects: rank order and paired comparisons, and two different sets of scaled stimuli were presented. A reliability measure was also taken as apparent context effects could merely be due to lack of reliability. The obtained data supported the basic assumptions of Coombs' theory, and subjects' responses were highly reliable, thus little confounding should have occurred. The change of context effects, however, were contrary to the prediction of Coombs' theory. Strong evidence for these context effects was found for both sets of stimuli and both kinds of tasks implemented. Implications of these findings are discussed and doubts are raised concerning the usefulne.
Commitment and Dyadic Coping in Long-Term Relationships

Background: Previous research focused on relationship commitment as the outcome of high satisfaction, poor alternatives, and high investments. We propose that commitment is a prerequisite in highly satisfied couples, fostering relationship maintenance behavior such as positive dyadic coping. Method: Structural equation models identified the relationship between commitment, relationship satisfaction, and dyadic coping with data from 201 heterosexual couples with an average relationship length of 34 years. Results: The common fate model confirmed that relationship satisfaction mediated the effects between commitment and dyadic coping on a latent dyadic level. Additional analyses revealed that women’s satisfaction was mainly responsible for mediating effects between both partners’ commitment and dyadic coping. Conclusions: Findings support the essentiality of commitment for couples’ maintenance strategies and for consistency in long-term relationships.
Tourists’ Perceptions of Relational Quality Service Attributes: A Cross-Cultural Study

This article presents the results of a study examining cultural differences between Asian and Western tourists’ perceptions of relational quality service provided by guest-contact employees. It was hypothesized that Asian tourists (high power distance cultures) will give significantly lower ratings for relational quality when compared to their Western counterparts (low power distance cultures). Based on a study of international tourists visiting Hong Kong, it was found that Asian tourists gave significantly lower ratings for all the relational quality service attributes compared to their Western counterparts. In a logistic regression analysis using respondents’ favorable or unfavorable service experiences as the dichotomous dependent variable, quality of interpersonal relationships was a key factor in determining the Asian customers’ service-encounter evaluation, while Western customers placed emphasis on goal completion, efficiency, and time savings. The implications of the results on cultural training for tourism and hospitality industry employees are also discussed.
Guilt Appeals and Prosocial Behavior: An Experimental Analysis of the Effects of Anticipatory Versus Reactive Guilt Appeals on the Effectiveness of Blood Donor Appeals

This study investigates the effectiveness of guilt-arousing communication in promoting prosocial behavior. By analyzing the distinct effects of anticipatory versus reactive guilt appeals, we contribute to the discussion of guilt appeals as drivers of prosocial behavior, especially blood donation. Research on persuasive communication provides the theoretical basis of our study and we validate our hypotheses by means of two 2 × 2 factorial between-subjects designs. We find that anticipatory rather than reactive guilt appeals are more effective in generating prosocial action tendencies. Compared to noninformational reference group influences, messages endorsed by members of informational reference groups yielded more favorable attitudinal responses. Besides their significant main effect, two-sided messages reinforce the favorable impact of anticipatory guilt appeals. The study concludes with practical implications for nonprofit organizations and public blood donor services as well as avenues for future research.
Hardware Support for Accelerating Data Movement in Server Platform

Data movement (memory copies) is a very common operation during network processing and application execution on servers. The performance of this operation is rather poor on today's microprocessors due to the following aspects: 1) Several long-latency memory accesses are involved because the source and/or the destination are typically in memory, 2) latency hiding techniques, such as out-of-order execution, hardware threading, and prefetching, are not very effective for bulk data movement, and 3) microprocessors move data at register (small) granularity. In this paper, we show this overhead of bulk data movement and propose the use of dedicated copy engines to minimize it. We present a detailed analysis of copy engine architectures along two dimensions: 1) on-die versus off-die and 2) synchronous versus asynchronous. These copy engine architectures are superior to traditional direct memory access (DMA) engines because they are tightly coupled to the core architecture and enable lower overhead communication and signaling. We describe the hardware support required to implement these copy engines and integrate them into server platforms. We perform a detailed case study to evaluate the performance of these copy engines. The evaluation is based on an execution-driven simulator, which was extended with detailed models of copy engines. Our simulation results show that copy engines are effective in reducing the bulk data movement overhead and, hence, hold significant promise for high-performance server platforms