Miracle-dz/UniFAR-FTUs huggingface dataset:
Globular Cluster Systems and the Missing Satellite Problem: Implications for Cold Dark Matter Models

We analyze the metallicity distributions of globular clusters belonging to 28 early-type galaxies in the survey of Kundu & Whitmore. A Monte Carlo algorithm that simulates the chemical evolution of galaxies that grow hierarchically via dissipationless mergers is used to determine the most probable protogalactic mass function for each galaxy. Contrary to the claims of Kundu & Whitmore, we find that the observed metallicity distributions are in close agreement with the predictions of such hierarchical formation models. The mass spectrum of protogalactic fragments for the galaxies in our sample has a power-law behavior, n(M) ∝ Mα, with an index of α ≃ -2. This spectrum is indistinguishable from the mass spectrum of dark matter halos predicted by cold dark matter models for structure formation. We argue that these protogalactic fragments—the likely sites of globular cluster formation in the early universe—are the disrupted remains of the "missing" satellite galaxies predicted by cold dark matter models. Our findings suggest that the solution to the missing satellite problem is through the suppression of gas accretion in low-mass halos after reionization, or via self-interacting dark matter, and argue against models with suppressed small-scale power or warm dark matter.
SHIP-1 Increases Early Oxidative Burst and Regulates Phagosome Maturation in Macrophages1

Although the inositol phosphatase SHIP-1 is generally thought to inhibit signaling for Fc receptor-mediated phagocytosis, the product of its activity, phosphatidylinositol 3,4 bisphosphate (PI(3,4)P2), has been implicated in activation of the NADPH oxidase. This suggests that SHIP-1 positively regulates the generation of reactive oxygen species after phagocytosis. To examine how SHIP-1 activity contributes to Fc receptor-mediated phagocytosis, we measured and compared phospholipid dynamics, membrane trafficking, and the oxidative burst in macrophages from SHIP-1-deficient and wild-type mice. SHIP-1-deficient macrophages showed significantly elevated ratios of PI(3,4,5)P3 to PI(3,4)P2 on phagosomal membranes. Imaging reactive oxygen intermediate activities in phagosomes revealed decreased early NADPH oxidase activity in SHIP-1-deficient macrophages. SHIP-1 deficiency also altered later stages of phagosome maturation, as indicated by the persistent elevation of PI(3)P and the early localization of Rab5a to phagosomes. These direct measurements of individual organelles indicate that phagosomal SHIP-1 enhances the early oxidative burst through localized alteration of the membrane 3′-phosphoinositide composition.
Prevalence of antibodies against Toxoplasma gondii and Neospora caninum in dogs

Toxoplasmosis and neosporosis are parasitic diseases of global importance. The present study had the objective to determine the influence of age, sex and breed in the prevalence of antibodies against both diseases in dogs from Brotas city, São Paulo State, Brazil. Blood samples of 342 dogs were collected, and the age, sex and breed of each animal were recorded. The serological diagnosis for toxoplasmosis and neosporosis were performed using the immunofluorescent antibody test (IFAT). The Fischer’s test was used to calculate the association probability of the variables, with α = 5%. For toxoplasmosis the prevalence of antibodies was 26.9% (CI 95% 22.4–31.8%), and for neosporosis 4.97% (CI 95% 3.1–7.8%). The statistical analysis revealed a higher risk of infection for T. gondii in dogs with more than five years.
Gravitational radiation from compact binary systems: Gravitational waveforms and energy loss to second post-Newtonian order.

We derive the gravitational waveform and gravitational-wave energy flux generated by a binary star system of compact objects (neutron stars or black holes), accurate through second post-Newtonian order ($O[(v/c)~4] \sim O[(Gm/rc~2)~2]$) beyond the lowest-order quadrupole approximation. We cast the Einstein equations into the form of a flat-spacetime wave equation together with a harmonic gauge condition, and solve it formally as a retarded integral over the past null cone of the chosen field point. The part of this integral that involves the matter sources and the near-zone gravitational field is evaluated in terms of multipole moments using standard techniques; the remainder of the retarded integral, extending over the radiation zone, is evaluated in a novel way. The result is a manifestly convergent and finite procedure for calculating gravitational radiation to arbitrary orders in a post-Newtonian expansion. Through second post-Newtonian order, the radiation is also shown to propagate toward the observer along true null rays of the asymptotically Schwarzschild spacetime, despite having been derived using flat spacetime wave equations. The method cures defects that plagued previous ``brute- force'' slow-motion approaches to the generation of gravitational radiation, and yields results that agree perfectly with those recently obtained by a mixed post-Minkowskian post-Newtonian method. We display explicit formulae for the gravitational waveform and the energy flux for two-body systems, both in arbitrary orbits and in circular orbits. In an appendix, we extend the formalism to bodies with finite spatial extent, and derive the spin corrections to the waveform and energy loss.
The Formation and Evolution of Planetary Systems (FEPS): Discovery of an Unusual Debris System Associated with HD 12039

We report the discovery of a debris system associated with the ~30 Myr old G3/5V star HD 12039 using Spitzer Space Telescope observations from 3.6-160 μm. An observed infrared excess (LIR/L* = 1 × 10-4) above the expected photosphere for λ ≳ 14 μm is fit by thermally emitting material with a color temperature of T ~ 110 K, warmer than the majority of debris disks identified to date around Sun-like stars. The object is not detected at 70 μm with a 3 σ upper limit 6 times the expected photospheric flux. The spectrum of the infrared excess can be explained by warm, optically thin material comprised of blackbody-like grains of size ≳7 μm that reside in a belt orbiting the star at 4-6 AU. An alternate model dominated by smaller grains, near the blowout size a ~ 0.5 μm, located at 30-40 AU is also possible but requires the dust to have been produced recently, since such small grains will be expelled from the system by radiation pressure in approximately a few times 102 yr.
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54, in governing the onset of puberty in the mouse. In the adult male and female mouse, kisspeptin (10–100 nm) evoked a remarkably potent, long-lasting depolarization of >90% of gonadotropin-releasing hormone (GnRH)–green fluorescent protein neurons in situ. In contrast, in juvenile [postnatal day 8 (P8) to P19] and prepubertal (P26–P33) male mice, kisspeptin activated only 27 and 44% of GnRH neurons, respectively. This developmental recruitment of GnRH neurons into a kisspeptin-responsive pool was paralleled by an increase in the ability of centrally administered kisspeptin to evoke luteinizing hormone secretion in vivo. To learn more about the mechanisms through which kisspeptin–GPR54 signaling at the GnRH neuron may change over postnatal development, we performed quantitative in situ hybridization for kisspeptin and GPR54 transcripts. Approximately 90% of GnRH neurons were found to express GPR54 mRNA in both juvenile and adult mice, without a detectable difference in the mRNA content between the age groups. In contrast, the expression of KiSS-1 mRNA increased dramatically across the transition from juvenile to adult life in the anteroventral periventricular nucleus (AVPV; p < 0.001). These results demonstrate that kisspeptin exerts a potent depolarizing effect on the excitability of almost all adult GnRH neurons and that the responsiveness of GnRH neurons to kisspeptin increases over postnatal development. Together, these observations suggest that activation of GnRH neurons by kisspeptin at puberty reflects a dual process involving an increase in kisspeptin input from the AVPV and a post-transcriptional change in GPR54 signaling within the GnRH neuron.
To what extent are teaching assistants really managed?: ‘I was thrown in the deep end, really; I just had to more or less get on with it’

ABSTRACT The main aim of this research was to secure a better understanding of how local authorities (LAs), senior leadership teams (SLTs) and teachers in state schools perceive their responsibilities for the deployment, leadership and management of teaching assistants (TAs). Current research in the field – some of which has been highly influential on policy – has largely focused on aspects of TA performance and pupil attainment. Importantly, we have chosen to investigate how TAs and SLTs themselves describe their experiences of management. TAs, teachers, senior leaders in primary schools and LA advisors, across two LAs, were surveyed. Based on 55 questionnaire responses, 23 interviews and 2 focus groups we found evidence of a dislocation of management priorities for effective TA deployment. What emerged was a strong sense of ‘otherness’ felt by many TAs, who believed themselves to be dissociated from their own management. We conclude that TAs make up a workforce that appears to be closely managed but which is in fact often poorly led, resulting in feelings of detachment.
Edinburgh Neural Machine Translation Systems for WMT 16

We participated in the WMT 2016 shared news translation task by building neural translation systems for four language pairs, each trained in both directions: English Czech, English German, English Romanian and English Russian. Our systems are based on an attentional encoder-decoder, using BPE subword segmentation for open-vocabulary translation with a fixed vocabulary. We experimented with using automatic back-translations of the monolingual News corpus as additional training data, pervasive dropout, and target-bidirectional models. All reported methods give substantial improvements, and we see improvements of 4.3--11.2 BLEU over our baseline systems. In the human evaluation, our systems were the (tied) best constrained system for 7 out of 8 translation directions in which we participated.
Up-to-date catalogues of yeast protein complexes

Gold standard datasets on protein complexes are key to inferring and validating protein–protein interactions. Despite much progress in characterizing protein complexes in the yeast Saccharomyces cerevisiae, numerous researchers still use as reference the manually curated complexes catalogued by the Munich Information Center of Protein Sequences database. Although this catalogue has served the community extremely well, it no longer reflects the current state of knowledge. Here, we report two catalogues of yeast protein complexes as results of systematic curation efforts. The first one, denoted as CYC2008, is a comprehensive catalogue of 408 manually curated heteromeric protein complexes reliably backed by small-scale experiments reported in the current literature. This catalogue represents an up-to-date reference set for biologists interested in discovering protein interactions and protein complexes. The second catalogue, denoted as YHTP2008, comprises 400 high-throughput complexes annotated with current literature evidence. Among them, 262 correspond, at least partially, to CYC2008 complexes. Evidence for interacting subunits is collected for 68 complexes that have only partial or no overlap with CYC2008 complexes, whereas no literature evidence was found for 100 complexes. Some of these partially supported and as yet unsupported complexes may be interesting candidates for experimental follow up. Both catalogues are freely available at: http://wodaklab.org/cyc2008/.
Rotinas produtivas sobre meio ambiente e perspectivas do jornalismo ambiental no Brasil

Demonstra a urgencia de uma comunicacao ambiental mais presente no Brasil, a historia desse movimento e estrategias possiveis para sua efetivacao. A autora apresenta as justificativas para a praxis de um jornalismo ambiental voltado para as politicas publicas da area e que acompanhe o agravamento dos conflitos sociais e ecologicos do planeta. Isso nao implica necessariamente a abordagem de aspectos negativos ou catastrofes apelativas. O reconhecimento de iniciativas sustentaveis e o esforco midiatico de torna-las populares e um dever – ainda mal cumprido – pela maioria dos meios de comunicacao brasileiros. A proposta para o exercicio do jornalismo fundamenta-se em uma mudanca de concepcao para a disseminacao de informacoes que contribuam para o pleno exercicio da cidadania – o que envolve nao apenas um relacionamento mais responsavel com o meio ambiente, mas com assuntos das esferas politica, economica, cultural etc. O modelo compartimentado de informacao nao auxilia o publico a perceber as interconexoes politicas, culturais e economicas dos saberes, que resultam em consequencias ambientais. Estrategias eficazes e coerentes diante das demandas mais essenciais da humanidade se fazem urgentes e significam mudancas de linguagem, conteudo e formatacao das noticias. A autora apresenta ainda um estudo de caso das noticias publicadas sobre a Baia de Guanabara para demonstrar a importância da informacao regional para a sustentabilidade em longo prazo. A informacao localizada proporciona participacao politica e social, viabiliza a cidadania, promove conscientizacao e responsabilizacao sobre os atos que afetam o ambiente comum. Em um pais com serias restricoes educacionais, a midia pode exercer seu papel social da maneira mais concreta ao se deixar guiar pelo lema primordial da ecologia: agir localmente e se comprometer globalmente.
Decentralized Sparsity-Regularized Rank Minimization: Algorithms and Applications

Given a limited number of entries from the superposition of a low-rank matrix plus the product of a known compression matrix times a sparse matrix, recovery of the low-rank and sparse components is a fundamental task subsuming compressed sensing, matrix completion, and principal components pursuit. This paper develops algorithms for decentralized sparsity-regularized rank minimization over networks, when the nuclear- and ℓ1-norm are used as surrogates to the rank and nonzero entry counts of the sought matrices, respectively. While nuclear-norm minimization has well-documented merits when centralized processing is viable, non-separability of the singular-value sum challenges its decentralized minimization. To overcome this limitation, leveraging an alternative characterization of the nuclear norm yields a separable, yet non-convex cost minimized via the alternating-direction method of multipliers. Interestingly, if the decentralized (non-convex) estimator converges, under certain conditions it provably attains the global optimum of its centralized counterpart. As a result, this paper bridges the performance gap between centralized and in-network decentralized, sparsity-regularized rank minimization. This, in turn, facilitates (stable) recovery of the low rank and sparse model matrices through reduced-complexity per-node computations, and affordable message passing among single-hop neighbors. Several application domains are outlined to highlight the generality and impact of the proposed framework. These include unveiling traffic anomalies in backbone networks, and predicting networkwide path latencies. Simulations with synthetic and real network data confirm the convergence of the novel decentralized algorithm, and its centralized performance guarantees.
Cross-Validation of the Discrimination and Calibration Properties of the VRAG-R in a Treated Sexual Offender Sample

The present study featured an examination of the predictive properties of the Violence Risk Appraisal Guide–Revised (VRAG-R) in a treated sample of sexual offenders, using modern risk metrics. The Sex Offender Risk Appraisal Guide (SORAG) and the original Violence Risk Appraisal Guide (VRAG) were examined for comparison purposes. The three measures were rated archivally on 296 treated sexual offenders followed up 17.6 years. VRAG-R scores demonstrated good discrimination of recidivists from nonrecidivists for sexual (area under the curve [AUC] = .60-.67) and violent (AUC = .70-.78) recidivism, and were incremental in the prediction of violent, but not sexual, recidivism after controlling for baseline sexual violence risk and treatment change. The VRAG-R bin structure demonstrated good calibration, although the present sample generated lower 5-year estimates of general violence compared with the normative sample. Application of the VRAG-R in the assessment and management of violence risk, via integration with dynamic risk assessment information, is discussed.
Non-conscious processes in changing health-related behaviour: a conceptual analysis and framework

ABSTRACT Much of the global burden of non-communicable disease is caused by unhealthy behaviours that individuals enact even when informed of their health-harming consequences. A key insight is that these behaviours are not predominantly driven by deliberative conscious decisions, but occur directly in response to environmental cues and without necessary representation of their consequences. Consequently, interventions that target non-conscious rather than conscious processes to change health behaviour may have significant potential, but this important premise remains largely untested. This is in part due to the lack of a practicable conceptual framework that can be applied to better describe and assess these interventions. We propose a framework for describing or categorising interventions to change health behaviour by the degree to which their effects may be considered non-conscious. Potential practical issues with applying such a framework are discussed, as are the implications for further research to inform the testing and development of interventions. A pragmatic means of conceptualising interventions targeted at non-conscious processes is a necessary prelude to testing the potency of such interventions. This can ultimately inform the development of interventions with the potential to shape healthier behaviours across populations.
First 101 Robotic General Surgery Cases in a Community Hospital

Background and Objectives: The general surgeon's robotic learning curve may improve if the experience is classified into categories based on the complexity of the procedures in a small community hospital. The intraoperative time should decrease and the incidence of complications should be comparable to conventional laparoscopy. The learning curve of a single robotic general surgeon in a small community hospital using the da Vinci S platform was analyzed. Methods: Measured parameters were operative time, console time, conversion rates, complications, surgical site infections (SSIs), surgical site occurrences (SSOs), length of stay, and patient demographics. Results: Between March 2014 and August 2015, 101 robotic general surgery cases were performed by a single surgeon in a 266-bed community hospital, including laparoscopic cholecystectomies, inguinal hernia repairs; ventral, incisional, and umbilical hernia repairs; and colorectal, foregut, bariatric, and miscellaneous procedures. Ninety-nine of the cases were completed robotically. Seven patients were readmitted within 30 days. There were 8 complications (7.92%). There were no mortalities and all complications were resolved with good outcomes. The mean operative time was 233.0 minutes. The mean console operative time was 117.6 minutes. Conclusion: A robotic general surgery program can be safely implemented in a small community hospital with extensive training of the surgical team through basic robotic skills courses as well as supplemental educational experiences. Although the use of the robotic platform in general surgery could be limited to complex procedures such as foregut and colorectal surgery, it can also be safely used in a large variety of operations with results similar to those of conventional laparoscopy.
Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval

The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a 1-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information. Together, these findings suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences. DOI: http://dx.doi. org/10.7554/eLife.05025. 001
Towards User-Adaptive Information Visualization

This paper summarizes an ongoing multi-year project aiming to uncover knowledge and techniques for devising intelligent environments for user-adaptive visualizations. We ran three studies designed to investigate the impact of user and task characteristics on user performance and satisfaction in different visualization contexts. Eye-tracking data collected in each study was analyzed to uncover possible interactions between user/task characteristics and gaze behavior during visualization processing. Finally, we investigated user models that can assess user characteristics relevant for adaptation from eye tracking data.
Submucosal Hemangioma of the Trachea in an Infant: Diagnosis and Follow-Up with 3D-CT/Bronchoscopy

Introduction: Infantile hemangiomas of the airway are diagnosed at bronchoscopy as part of the investigation of stridor or other respiratory symptoms. Here, we present three-dimensional computed tomography (3D-CT)/bronchoscopy findings of submucosal subglottic hemangioma missed at bronchoscopy. Case Presentation: We report on the clinical usefulness of 3D-CT/bronchoscopy as the primary diagnostic tool and follow-up method in the evaluation of suspected airway infantile hemangiomas, especially when the hemangioma is the submucosal type. Conclusions: 3D-CT/bronchoscopy will reduce the need for invasive laryngoscopic studies and help to diagnose submucosal hemangiomas undetected on laryngoscope. Additionally, 3D-CT/bronchoscopy will help evaluating the extent of the lesion, degree of airway narrowing, and treatment response.
Investigating the collocational behaviour ofmanandwomanin the BNC using Sketch Engine1

In this paper, I examine the representation of men and women in the British National Corpus (BNC) by focussing on the collocational and grammatical behaviour of the noun lemmas man and woman (i.e., the nouns man/men and woman/women ). Using Sketch Engine (a powerful corpus query tool, which is described) I explore the functional distribution of the target lemmas, and reveal the structured and systematic nature of the differences in the way these terms for adult male and female human beings pattern with other word forms in different grammatical relations.