Miracle-dz/UniFAR-FTUs huggingface dataset:
Perceived Harmfulness of Substance Use: A Pilot Study

Background: Harm ratings of substances help in understanding the perception toward substance use and formulating policies. Evidence of such harm ratings by substance users and their caregivers provides a clearer perspective of those who experience and observe such harm closely. Materials and Methods: Substance users and their caregivers were recruited from the Drug De-addiction and Treatment Centre of PGIMER, Chandigarh. Sociodemographic details of the subjects were noted. The subjects were then asked to rate a list of psychoactive preparations according to the harms they thought the preparation caused. The list of substances was developed taking into consideration substance commonly encountered in the geographical area. The harm ratings were transformed on a scale of 0-100. Results: All subjects were males and majority of them were educated above 10th standard, were not employed and belonged to urban background. Most of them had taken psychoactive substances in their lifetimes but were currently abstinent. Most of the subjects endorsed intravenous drugs as the most harmful, followed by heroin. Beer and chewable tobacco considered the least harmful substances. Greater degree of education was associated with lower harm rankings for heroin, cannabis, dextropropoxyphene, and raw opium; while urban residence was associated with greater harm ratings for cannabis and raw opium. Differences in the harms were perceived for different preparations of the same active compound for alcohol and nicotine. Conclusion: Harm ratings of substances can be a useful guide while formulating policies and allocating resources. Need for further research extending this pilot study is emphasized.
What Does Successful Aging Sound Like? Profiling Communication About Aging

We draw on the recently developed communicative ecology model of successful aging (CEMSA) to examine how adults communicate about aging and how these communication patterns relate to experiences of successful aging. Using latent class analysis across 2 datasets collected in New Zealand and the United States, we identify 3 distinct classes of agers (disengaged, engaged, and bantering) defined by different profiles of communication behavior. Across samples, an engaged profile was generally associated with the most positive experiences of aging, whereas a disengaged profile was associated with the least positive experiences, although these differences were surprisingly small. Our results highlight the diverse ways in which individuals communicatively engage with the process of aging and experience aging as positive and successful.
Measuring Cognitive Function With Age: The Influence of Selection by Health and Survival

Background: Research into the pathophysiology of age-associated cognitive function and decline requires a valid estimate of cognitive function. However, this estimation can be grossly influenced by a selective loss to follow-up. Methods: We investigated the influence of health selection on the estimated age-associated cognitive function and decline by studying the effect on this estimation of study design and of the handling of multiple and missing data. We used linear regression analyses and linear mixed models to assess cognitive function from cross-sectional and longitudinal data. Repeated measures of cognitive function (assessed with dedicated neuropsychological tests) were carried out in 2 independent population-based cohort studies: the Rotterdam Study (3719 participants; mean age 71 years) and the Leiden 85-plus Study (369 participants; age 85 years). Results: The effect of age on cognitive function was greater in cross-sectional analyses when all participants were included than when analyses were restricted to participants with repeated measurements. The decline in cognitive function over 4.6 years of follow-up was intermediate between the cross-sectional estimates from the total sample and from the restricted sample. Moreover, the estimated decline in cognitive function was larger when using a short follow-up than when using the complete follow-up over 5 years. The estimated decline using linear mixed models was similar to analyses including those with a complete follow-up over 5 years. Conclusion: Selection for health and survival results in better age-specific cognitive test scores and less cognitive decline. Statistical methods handling multiple and missing data do not fully correct for this bias.
AN UNUSUAL ZONE SURROUNDING COLISTIN DISCS IN SENSITIVITY TESTS OF SERRATIA MARCESCENS

5. Fractures and fracture disclocations in flexion tend to OCCur more commonly in the upper spine. Immediate skeletal traction is the absolute requirement. 6. Malalignment of the spine in flexion injuries may persist in traction, with locking of the facets which may render it stable, or may recur when traction is removed. Whatever the nature of persistent or recurrent malalignment with enroachment on the anterior aspect of the theca, it should not be allowed to remain, and open reduction of the dislocation and fixation seem imperative, no matter how complete may appear the cord transection sYndrome in the acute stage, whilst the patient remains in traction. In such cases, decompressive laminectomy is eontraindicated because of the position required for operation, which may easily result in added vascular damage; the latter cannot be prevented in most experienced bands, because there is no visual control of the radicular arteries, and even transient occlusion of one of these may increase the already present insufficiency of the anterior spinal artery to the critical level of infarction. Therefore, anterior interbody decompression and fusion with fixation, with the patient operated on in traction and extension, is the method of choice.
Do footfall patterns in forefoot runners change over an exhaustive run?

ABSTRACT The purpose of this study was to investigate possible footfall pattern changes in habitual forefoot runners over a prolonged, exhaustive run. A prolonged run was performed to exhaustion in 14 habitual forefoot runners. Vertical ground reaction forces (VGRFs) and kinematics were collected at the beginning and end of the run. Ankle plantar flexor torque and triceps surae electromyographic activity were measured during pre- and post-run isometric contractions. By run’s end, there was an increase in VGRF loading rate and impact peak magnitude, greater dorsiflexion at foot contact and greater knee flexion angle throughout stance. Ankle plantar flexor torque decreased significantly from pre- to post-run tests. This was accompanied by a decrease in the integrated electromyographic activity (iEMG) output for the lateral and medial gastrocnemius. There were significant changes in landing mechanics for forefoot runners that indicate a transition towards more midfoot footfall patterns. A contributing factor may be ankle plantar flexor muscle fatigue that, at touchdown, is exposed to exaggerated eccentric loading. These findings suggest that a forefoot running pattern may become difficult to maintain in longer endurance events, and thus runners should pay attention to this in training to improve performance and mitigate potential injury.
Examination of Multicultural Counseling Competencies in School Counselors.

The study investigated 227 school counselor’s multicultural counseling competencies (MCC). MCC were measured with a self-report inventory, and with ratings of responses to short vignettes, designed to assess “demonstrated” competency. Results indicated that school counselor self-ratings did not predict demonstrated ratings of MCC. People of color self-reported higher MCC. A significant effect for age and teaching experience was found with two of the four vignettes, with younger counselors and those with less teaching experience having more highly rated responses. Years of counseling experience was also significantly related to responses on one vignette, with less experienced counselors receiving higher ratings.
Double-Layer Plaque Assay for Quantification of Enteroviruses

ABSTRACT We describe here a double-layer plaque assay for the quantification of enteroviruses, combining a monolayer plaque assay and a suspended-cell plaque assay. The double-layer assay provides significantly greater counts than other methods of virus quantification of both suspensions of pure culture viruses and naturally occurring viruses. The counts obtained by this method are approximately one order of magnitude greater than those obtained with the more commonly used method, the monolayer plaque assay. We conclude that the methods available for quantifying viruses rank in efficiency as follows: double-layer plaque assay ≥ suspended-cell plaque assay > counting cytopathogenic virus adsorbed to cellulose nitrate membrane filters ≥ most probable number of cytopathogenic units > monolayer plaque assay. Moreover, the double-layer plaque assay allows the use of two different cell lines in the two layers. Using the human colonic carcinoma cell line CaCo2 facilitates the recovery of a greater number and diversity of naturally occurring enteroviruses in water than the monolayer agar method. In addition, the pretreatment of cells with 5-iodo-2′-deoxyuridine (IDU) prior to the quantification of enteroviruses by the double-layer plaque assay provides significantly higher recoveries than the use of IDU does with the other methods of quantification.
Oral non-Hodgkin’s lymphoma in a patient with rheumatoid arthritis treated with etanercept and methotrexate

Oral non-Hodgkin’s lymphomas (O-NHLs) are a rare group of diverse lymphoid tissue malignancies and represent less than 5% of the oral cavity malignancies and 2% of all extra-nodal NHLs. Oral-NHLs affect the Waldeyer’s-ring, the salivary glands, the bone of the jaws and the oral mucosa, their clinical appearance is very heterogeneous. Among the risk factors for NHLs are immunosuppression (primary or secondary), autoimmunity and inflammation. O-NHLs share the same risk factors. This case report describes a patient with O-NHL which was possibly linked to the combination of methotrexate and etanercept for the treatment of her rheumatoid arthritis. To our knowledge this is probably among the first cases of O-NHL with possible relation to the use of a Tumor Necrosis Factor (TNF) antagonist biological agent (etanercept). This case could contribute to the sensitization of the dentists for the signs and symptoms of this rare malignancy. It also underlines the need for thorough medical history and medication recording for all the dental patients. Key words:Lymphoma (oral) methotrexate, etanercept.
Relationship Characteristics of American Gay and Lesbian Couples

A total of 1,749 self-selected gay men and lesbians representing 560 gay couples and 706 lesbian couples were surveyed concerning their relationships. Respondents had been in their relationships an average of 6 years. Findings form 13 topics relevant to relationships underscore the diversity and complicity of same sex couples. Primary attention is given to distinctions between male and female couples and factors correlated with relationship quality.
Temporal changes of surface wave velocity associated with major Sumatra earthquakes from ambient noise correlation

Detecting temporal changes of the medium associated with major earthquakes has implications for understanding earthquake genesis. Here we report temporal changes of surface wave velocity over a large area associated with 3 major Sumatra earthquakes in 2004, 2005, and 2007. We use ambient noise correlation to retrieve empirical Green's function (EGF) of surface waves between stations. Because the process is completely repeatable, the technique is powerful in detecting possible temporal change of medium. We find that 1 excellent station pair (PSI in Indonesia and CHTO in Thailand) shows significant time shifts (up to 1.44 s) after the 2004 and 2005 events in the Rayleigh waves at 10–20 s but not in the Love waves, suggesting that the Rayleigh time shifts are not from clock error. The time shifts are frequency dependent with the largest shifts at the period band of 11–16 s. We also observe an unusual excursion ∼1 month before the 2004 event. We obtain a total of 17 pairs for June, 2007 to June, 2008, which allow us to examine the temporal and spatial variation of the time shifts. We observed strong anomalies (up to 0.68 s) near the epicenter after the 2007 event, but not in the region further away from the source or before the event or 3 months after the event. The observations are interpreted as stress changes and subsequent relaxation in upper-mid crust in the immediate vicinity of the rupture and the broad area near the fault zone.
Artificial Evolution of Life History and Behavior

We present an individual‐based model that uses artificial evolution to predict fit behavior and life‐history traits on the basis of environmental data and organism physiology. Our main purpose is to investigate whether artificial evolution is a suitable tool for studying life history and behavior of real biological organisms. The evolutionary adaptation is founded on a genetic algorithm that searches for improved solutions to the traits under scrutiny. From the genetic algorithm’s “genetic code,” behavior is determined using an artificial neural network. The marine planktivorous fish Müller’s pearlside (Maurolicus muelleri) is used as the model organism because of the broad knowledge of its behavior and life history, by which the model’s performance is evaluated. The model adapts three traits: habitat choice, energy allocation, and spawning strategy. We present one simulation with, and one without, stochastic juvenile survival. Spawning pattern, longevity, and energy allocation are the life‐history traits most affected by stochastic juvenile survival. Predicted behavior is in good agreement with field observations and with previous modeling results, validating the usefulness of the presented model in particular and artificial evolution in ecological modeling in general. The advantages, possibilities, and limitations of this modeling approach are further discussed.
Delayed primary excision with subsequent modification of radiotherapy dose for intermediate‐risk rhabdomyosarcoma: A report from the Children's Oncology Group Soft Tissue Sarcoma Committee

The majority of intermediate‐risk rhabdomyosarcoma (RMS) patients have gross residual disease (Group III) after their first operative procedure. It is currently not known if local control rates can be maintained when, following induction chemotherapy, the radiation therapy (RT) dose is decreased after a delayed primary excision (DPE). To answer this question we evaluated patients enrolled on COG D9803 (1999–2005) who had Group III tumors of the bladder dome, extremity or trunk (thorax, abdomen and pelvis) were candidates for DPE at Week 12 if the primary tumor appeared resectable. RT dose was then adjusted by the completeness of DPE: no evidence of disease 36 Gy, microscopic residual 41.4 Gy and gross residual disease (GRD) 50.4 Gy. A total of 161 Group III patients were evaluated (24 bladder dome, 63 extremity and 74 trunk). Seventy‐three patients (45%) underwent DPE which achieved removal of all gross disease in 61 (84%) who were then eligible for reduced RT dose (43/73 received 36 Gy, 19/73 received 41.4 Gy). The local 5‐year failure rate (0% for bladder dome, 7% for extremity and 20% for trunk) was similar to IRS‐IV, which did not encourage DPE and did not allow for DPE adapted RT dose reduction. In conclusion, DPE was performed in 45% of Group III RMS patients with tumors at select anatomic sites (bladder dome, extremity and trunk) and 84% of those who had DPE were eligible for RT dose reduction. Local control outcomes were similar to historic results with RT alone.
Evolution of sperm structure and energetics in passerine birds

Spermatozoa exhibit considerable interspecific variability in size and shape. Our understanding of the adaptive significance of this diversity, however, remains limited. Determining how variation in sperm structure translates into variation in sperm performance will contribute to our understanding of the evolutionary diversification of sperm form. Here, using data from passerine birds, we test the hypothesis that longer sperm swim faster because they have more available energy. We found that sperm with longer midpieces have higher levels of intracellular adenosine triphosphate (ATP), but that greater energy reserves do not translate into faster-swimming sperm. Additionally, we found that interspecific variation in sperm ATP concentration is not associated with the level of sperm competition faced by males. Finally, using Bayesian methods, we compared the evolutionary trajectories of sperm morphology and ATP content, and show that both traits have undergone directional evolutionary change. However, in contrast to recent suggestions in other taxa, we show that changes in ATP are unlikely to have preceded changes in morphology in passerine sperm. These results suggest that variable selective pressures are likely to have driven the evolution of sperm traits in different taxa, and highlight fundamental biological differences between taxa with internal and external fertilization, as well as those with and without sperm storage.
Grassland Ecology: An Analysis of Wolf Totem from an Ecological Perspective

Much discussion has been done on Jiang Rong’s presentation of the national character of the Chinese in Wolf Totem, so that it overshadows an equally important aspect of the novel: the grassland ecology. Thus, we aim to contrast the different attitudes towards nature of the nomadic Mongols on the one pole, and the Han Chinese, the migrant and young Mongols on the other. Besides, we try to summarize the nomads’s ecosophy as reflected in the novel. Ecotheory, especially Arne Naess’ ecosophy T offers a very efficient tool for our exploration. One problem yet to be solved, however, is the regression of the traditional ecosophy engendered by the challenges from different social forces such as politics and economy. Thus, how to preserve the traditional positive ecosophy needs efforts from all parties apart from the ecologists. Key words : Grassland ecology; Nomadic Mongols; Ecosophy; Regression
Risk Factors associated with Early Childhood Caries.

OBJECTIVE To analyse factors associated with the susceptibility of early childhood caries (ECC), populations with a high risk of ECC were screened and guidance for ECC prevention was proposed. METHODS A total of 392 children aged 24 to 71 months were selected for oral examination in Qingdao. Parents or guardians of the participants completed the questionnaires and decayed missing filled surface (dmfs) were recorded. Differences in caries condition and oral health behaviour in different families were compared. Risk factors related to ECC were screened. The subjects were finally grouped based on the obtained dmfs into three groups: caries-free, ECC and S-ECC (severe ECC). Association of risk factors with the caries status was analysed using the Kruskal-Wallis test, the chi-square test and logistic regression analysis. RESULTS There were significant differences among the caries-free, ECC and S-ECC groups in three parameters: eating too many sweets each day, brushing before and after sleeping, and whether parents helped to brush (P < 0.01). Combined factors such as the parents' level of education, oral health knowledge, attitudes, the family's annual income, the age of children when they start to brush and not brushing regularly were also significantly related to ECC (P < 0.05). No significant differences were observed among the three groups for these factors, including birth condition and nursing state, physical condition of the mother during pregnancy, feeding situation, if a pacifier was used during sleep, duration of brushing, frequency of mouth rinsing after meals each day and brushing with fluoride toothpaste (P > 0.05). CONCLUSION Eating a lot of sweets, an incorrect brushing method, starting brushing at a later stage and not brushing regularly are susceptible factors for ECC. Emphasising oral health knowledge to parents and guardians, conducting proper brushing methods, limiting the frequency of sweets being eaten and avoiding an inappropriate habit of eating sweets are very important factors in the prevention of ECC.
Slope efficiency and dynamic range of traveling-wave multiple-quantum-well electroabsorption modulators

High-performance InGaAsP-InP multiple-quantum-well traveling-wave electroabsorption modulators (EAMs) have been developed for analog optical links. A high slope efficiency of >4/V at 1.55 /spl mu/m for a 300-/spl mu/m-long EAM is measured. A detailed study of the nonlinearity and the spurious-free dynamic range (SFDR) is presented. By optimizing the bias voltage and the input optical power, the SFDR can be improved by 10-30 dB.
Adenosine A1 Receptor Antagonism Abolished the Anti-seizure Effects of Exogenous Ketone Supplementation in Wistar Albino Glaxo Rijswijk Rats

The state of therapeutic ketosis can be achieved by using the ketogenic diet (KD) or exogenous ketone supplementation. It was suggested previously that the adenosinergic system may be involved in the mediating effect of KD on suppressing seizure activity in different types of epilepsies, likely by means of adenosine A1 receptors (A1Rs). Thus, we tested in the present study whether exogenous ketone supplements (ketone ester: KE, 2.5 g/kg/day; ketone salt/KS + medium chain triglyceride/MCT: KSMCT, 2.5 g/kg/day) applied sub-chronically (for 7 days) by intragastric gavage can modulate absence epileptic activity in genetically absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. The number of spike-wave discharges (SWDs) significantly and similarly decreased after both KE and KSMCT treatment between 3rd and 7th days of gavage. Moreover, blood beta-hydroxybutyrate (βHB) levels were significantly increased alike after KE and KSMCT gavage, compared to control levels. The SWD number and βHB levels returned to the baseline levels on the first day without ketone supplementation. To determine whether A1Rs can modify ketone supplement-evoked changes in absence epileptic activity, we applied a non-pro-epileptic dose of a specific A1R antagonist DPCPX (1,3-dipropyl-8-cyclopentylxanthine) (intraperitoneal/i.p. 0.2 mg/kg) in combination with KSMCT (2.5 g/kg/day, gavage). As expected, DPCPX abolished the KSMCT-evoked decrease in SWD number. Thus, we concluded that application of exogenous ketone supplements may decrease absence epileptic activity in WAG/Rij rats. Moreover, our results suggest that among others the adenosinergic system, likely via A1Rs, may modulate the exogenous ketone supplements-evoked anti-seizure effects.
Men Not Included?

SUMMARY This paper explores debates about male presence and influence in lesbian families from a critical psychology standpoint. Critical psychology encompasses a variety of radical approaches to psychological research that reject traditional psychological assumptions, concepts and methods and that seek to challenge and resist normative values. To explore aspects of the discursive terrain of male influence and to demonstrate the merits of a critical psychology of lesbian families, excerpts from an interview with a lesbian couple who are members of a planned lesbian/gay family (two mummies and a daddy) are analysed. These excerpts show that debates about male influence create live dilemmas and tensions for the lesbian couple and have important consequences for how lesbian parents negotiate and do family.