Miracle-dz/UniFAR-FTUs huggingface dataset:
Total Precipitable Water Measurements from GOES Sounder Derived Product Imagery

Abstract Statistics are compiled comparing calculations of total precipitable water (TPW) as given by GOES sounder derived product imagery (DPI) to that computed from radiosonde data for the 12-month period March 1998–February 1999. In order to investigate the impact of the GOES sounder data, these results are evaluated against statistics generated from the comparison between the first guess fields used by the DPI (essentially Eta Model forecasts) and the radiosonde data. It is found that GOES data produce both positive and negative results. Biases in the first guess are reduced for moist atmospheres, but are increased in dry atmospheres. Time tendencies in TPW as measured by the DPI show a higher correlation to radiosonde data than does the first guess. Two specific examples demonstrating differences between the DPI and Eta Model forecasts are given.
Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease

Background Despite the notoriety of Ebola virus disease (EVD) as one of the world’s most deadly infections, EVD has a wide range of outcomes, where asymptomatic infection may be almost as common as fatality. With increasingly sensitive EVD diagnosis, there is a need for more accurate prognostic tools that objectively stratify clinical severity to better allocate limited resources and identify those most in need of intensive treatment. Methods/Principal Findings This retrospective cohort study analyses the clinical characteristics of 158 EVD(+) patients at the GOAL-Mathaska Ebola Treatment Centre, Sierra Leone. The prognostic potential of each characteristic was assessed and incorporated into a statistically weighted disease score. The mortality rate among EVD(+) patients was 60.8% and highest in those aged <5 or >25 years (p<0.05). Death was significantly associated with malaria co-infection (OR = 2.5, p = 0.01). However, this observation was abrogated after adjustment to Ebola viral load (p = 0.1), potentially indicating a pathologic synergy between the infections. Similarly, referral-time interacted with viral load, and adjustment revealed referral-time as a significant determinant of mortality, thus quantifying the benefits of early reporting as a 12% mortality risk reduction per day (p = 0.012). Disorientation was the strongest unadjusted predictor of death (OR = 13.1, p = 0.014) followed by hiccups, diarrhoea, conjunctivitis, dyspnoea and myalgia. Including these characteristics in multivariate prognostic scores, we obtained a 91% and 97% ability to discriminate death at or after triage respectively (area under ROC curve). Conclusions/Significance This study proposes highly predictive and easy-to-use prognostic tools, which stratify the risk of EVD mortality at or after EVD triage.
The Most Recently Discovered Carbonic Anhydrase, CA XV, Is Expressed in the Thick Ascending Limb of Henle and in the Collecting Ducts of Mouse Kidney

Background Carbonic anhydrases (CAs) are key enzymes for physiological pH regulation, including the process of urine acidification. Previous studies have identified seven cytosolic or membrane-bound CA isozymes in the kidney. Recently, we showed by in situ hybridization that the mRNA for the most novel CA isozyme, CA XV, is present in the renal cortex. CA XV is a unique isozyme among mammalian CAs, because it has become a pseudogene in primates even though expressed in several other species. Methodology/Principal Findings In the present study, we raised a polyclonal antibody against recombinant mouse CA XV that was produced in a baculovirus/insect cell expression system, and the antibody was used for immunohistochemical analysis in different mouse tissues. Positive immunoreactions were found only in the kidney, where the enzyme showed a very limited distribution pattern. Parallel immunostaining experiments with several other anti-CA sera indicated that CA XV is mainly expressed in the thick ascending limb of Henle and collecting ducts, and the reactions were most prominent in the cortex and outer medulla. Conclusion/Significance Although other studies have proposed a role for CA XV in cell proliferation, its tightly limited distribution may point to a specialized function in the regulation of acid-base homeostasis.
Catecholaminergic systems in the zebrafish. IV. Organization and projection pattern of dopaminergic neurons in the diencephalon

In the diencephalons of the adult zebrafish brain, all catecholamine‐containing neurons are dopaminergic. The organization and projection pattern of these neurons are studied using tyrosine hydroxylase immunocytochemistry. By their locations, 3 neuronal complexes and 17 cell groups are identified on the bases of their morphology, staining intensity, and projection pattern: 1) the preoptic complex (5 groups); 2) the posterior tuberal complex (4 groups); and 3) the hypothalamic complex (5 groups). In addition, three other groups can be distinguished: one group in the ventral thalamus; one in the pretectal area, and one found in the postoptic commissure and above the pituitary stalk in a few brains. Two dopaminergic pathways are defined: 1) the preoptico‐hypophyseal tract runs in close association with the lateral forebrain bundle along the base of the brain between the preoptic area and the pituitary stalk, and neurons of the preoptic complex are major contributors to this pathway; additional fibers come from the large periventricular organ‐associated neurons of the posterior tuberal; 2) the endohypothalamic tract links neurons of the hypothalamic complex and consists mainly of processes from hypothalamic neurons. Axons from neurons of the suprachiasmatic, periventricular organ‐associated, and posterior tuberal nuclei also join this pathways after entering the hypothalamus. Several groups of neurons contact the cerebrospinal fluid. These appear to be primarily local neurons because none have processes that join the two major pathways. The preoptic area, dorsal thalamus, tuberal and hypothalamic areas, optic tectum, and pituitary are the major targets of diencephalic dopaminergic neurons. The dorsal telencephalon does not receive input from these cells. The large periventricular organ‐accompanying neurons have descending projections beyond the diencephalon and isthmus. Some cells of this group terminate in the crista cerebellaris. A few axons also exit the medulla via a branch of the octavolateralis nerve. J. Comp. Neurol. 460:13–37, 2003. © 2003 Wiley‐Liss, Inc.
LLL reducing with the most significant bits

Let B be a basis of a Euclidean lattice, and B an approximation thereof. We give a sufficient condition on the closeness between B and B so that an LLL-reducing transformation U for B remains valid for B. Further, we analyse an efficient reduction algorithm when B is itself a small deformation of an LLL-reduced basis. Applications include speeding-up reduction by keeping only the most significant bits of B, reducing a basis that is only approximately known, and efficiently batching LLL reductions for closely related inputs.
Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.

Cardiac arrest due to torsade de pointes (TdP) in the acquired form of drug-induced long-QT syndrome (LQTS) is a rare but potentially catastrophic event in hospital settings. Administration of a QT-prolonging drug to a hospitalized population may be more likely to cause TdP than administration of the same drug to an outpatient population, because hospitalized patients often have other risk factors for a proarrhythmic response. For example, hospitalized patients are often elderly people with underlying heart disease who may also have renal or hepatic dysfunction, electrolyte abnormalities, or bradycardia and to whom drugs may be administered rapidly via the intravenous route. In hospital units where patients’ electrocardiograms (ECGs) are monitored continuously, the possibility of TdP may be anticipated by the detection of an increasing QT interval and other premonitory ECG signs of impending arrhythmia. If these ECG harbingers of TdP are recognized, it then becomes possible to discontinue the culprit drug and manage concomitant provocative conditions (eg, hypokalemia, bradyarrhythmias) to reduce the occurrence of cardiac arrest. The purpose of this scientific statement is to raise awareness among those who care for patients in hospital units about the risk, ECG monitoring, and management of drug-induced LQTS. Topics reviewed include the ECG characteristics of TdP and signs of impending arrhythmia, cellular mechanisms of acquired LQTS and current thinking about genetic susceptibility, drugs and drug combinations most likely to cause TdP, risk factors and exacerbating conditions, methods to monitor QT intervals in hospital settings, and immediate management of marked QT prolongation and TdP. The term torsade de pointes was coined by Dessertenne in 1966 as a polymorphic ventricular tachycardia characterized by a pattern of twisting points.1 Several ECG features are characteristic of TdP and are illustrated in Figure 1. First, a change in the amplitude and morphology (twisting) of the QRS …
Observation of Atomic Diffusion at Twin-Modified Grain Boundaries in Copper

Grain boundaries affect the migration of atoms and electrons in polycrystalline solids, thus influencing many of the mechanical and electrical properties. By introducing nanometer-scale twin defects into copper grains, we show that we can change the grain-boundary structure and atomic-diffusion behavior along the boundary. Using in situ ultrahigh-vacuum and high-resolution transmission electron microscopy, we observed electromigration-induced atomic diffusion in the twin-modified grain boundaries. The triple point where a twin boundary meets a grain boundary was found to slow down grain-boundary and surface electromigration by one order of magnitude. We propose that this occurs because of the incubation time of nucleation of a new step at the triple points. The long incubation time slows down the overall rate of atomic transport.
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation

Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a particularly strong influence on human growth. Therefore, we performed a genome-wide association study (GWAS) of body height using 2.2 million markers in 10 074 individuals from three Dutch and one German population-based cohorts. Upon genotyping, the 12 most significantly height-associated single nucleotide polymorphisms (SNPs) from this GWAS in 6912 additional individuals of Dutch and Swedish origin, a genetic variant (rs6717918) on chromosome 2q37.1 was found to be associated with height at a genome-wide significance level (Pcombined = 3.4 × 10−9). Notably, a second SNP (rs6718438) located ∼450 bp away and in strong LD (r2 = 0.77) with rs6717918 was previously found to be suggestive of a height association in 29 820 individuals of mainly northwestern European ancestry, and the over-expression of a nearby natriuretic peptide precursor type C (NPPC) gene, has been associated with overgrowth and skeletal anomalies. We also found a SNP (rs10472828) located on 5p14 near the natriuretic peptide receptor 3 (NPR3) gene, encoding a receptor of the NPPC ligand, to be associated with body height (Pcombined = 2.1 × 10−7). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height.
Alleviating linear ecological bias and optimal design with subsample data

Summary. We illustrate that combining ecological data with subsample data in situations in which a linear model is appropriate provides two main benefits. First, by including the individual level subsample data, the biases that are associated with linear ecological inference can be eliminated. Second, available ecological data can be used to design optimal subsampling schemes that maximize information about parameters. We present an application of this methodology to the classic problem of estimating the effect of a college degree on wages, showing that small, optimally chosen subsamples can be combined with ecological data to generate precise estimates relative to a simple random subsample.
Contributions to the Dimensional Assessment of Personality Disorders Using Millon's Model and the Millon Clinical Multiaxial Inventory (MCMI–III)

For over 35 years, Mllion's (1996) model of personality and the Millon Clinical Multiaxial Inventory (Millon, 1977, 1987, 2006) have been useful resources for clinicians to understand and assess personality disorders (PDs) and clinical syndromes in psychiatric patients. In this article, we highlight significant features of the model and test that have proved valuable to personologists in their quest for a more satisfactory taxonomy of PDs based on continuously distributed traits. We also describe Millon's (1996) prototypal domain approach to personality that combines dimensional and categorical elements for the description of PDs and their normal counterparts.
Lost in Transit: Product Replacement Bias and Pricing to Market

The microdata underlying U.S. import and export price indexes exhibit frequent product turnover and highly rigid prices. As a consequence, 40% of products are replaced before a single price change is observed and 70% are replaced after two price changes or less. An aggregate price index that focuses on price changes for identical items over time may, therefore, miss an important component of price adjustment occurring at the time of product replacements. We provide a model of this "product replacement bias" and quantify its importance using U.S. microdata on import and export prices. We show that, accounting for product replacement bias, long-run exchange rate "pass-through" into U.S. import and export price indexes is almost twice as high as conventional estimates suggest, and changes in the terms of trade are roughly 75% more volatile. Our adjustment makes pass-through statistics easier to account for with existing general equilibrium models.
Gingival recession: epidemiology and risk indicators in a university dental hospital in Turkey.

OBJECTIVE Gingival recession is a common manifestation of periodontal disease, but is also associated with several risk factors. In this study, we investigated prevalence of gingival recession and assessed various risk indicators in a university dental hospital in Turkey. MATERIALS AND METHODS The study group consisted of 831 persons (537 females, 294 males). Gingival recession, dental plaque, calculus, tobacco consumption, toothbrushing frequency, traumatic toothbrushing and high frenum were assessed. Gingival recession scored as present whenever the free gingival margin was apical to the cemento-enamel junction and root surface was exposed. RESULTS Overall, the prevalence of gingival recession was 78.2%. The gingival recession for buccal surfaces measured approximately between 1 and 2 mm was 17.4%. The number of gingival recession site of male subjects was significantly higher than that of the female ones (P < 0.05). The dental calculus and plaque levels of mandibular teeth were significantly higher than those of the maxillary teeth (P < 0.05). The multiple regression analyses showed that age, smoking duration, traumatic toothbrushing and high frenum are significant contributors to gingival recession. CONCLUSIONS Periodontal condition is very high in this population. High level of gingival recession in this population is significantly associated with a high level of dental plaque and calculus, male gender, smoking duration, toothbrushing frequency, traumatic toothbrushing and high frenum.
Identification of three Early Pleistocene tephras in and around the west part of the Musashino Upland, Tokyo, Northeast Japan

In and around the west part of the Musashino Upland, southwest of the Kanto Tectonic Basin, Ob4b-4 (1.62 Ma), Ob4b-1 (1.63 Ma), and Ob3 (1.71–1.78 Ma) tephras in the Kazusa Group, early Quaternary strata, were identified by using characteristic properties such as chemical composition of volcanic glass shards and titanomagnetite, and refractive indices of glass shards, hornblende, cummingtonite, and orthopyroxene. Changes in altitudes of Ob4b-1 identified in four cores and at three outcrops together with those by previous studies indicate geological structure of the Kazusa Group, revealing a gentle northeastward sloping with a gradient of 15/1000 and a prominent discontinuity of the strata along the Tachikawa Fault Zone.
Brain mechanism of response execution and inhibition: an event-related potential study

High-density event-related potentials were directly recorded to examine the electrophysiologic correlates of response execution (simple response), response inhibition (delaying response), and response imagination (imagining response) after response signals were provided. Results indicate that the simple response elicited a more positive event-related brain potential deflection (P370) than did the baseline task between 250 and 400 ms. Furthermore, two generators localized in the temporal-occipital junction and the anterior cingulate cortex contributed to this effect, which is possibly related to the identification and evaluation of stimulus and response monitoring. The delayed response also elicited a more negative event-related brain potential deflection (N470) than did the baseline task between 400 and 500 ms, and one generator localized in the anterior cingulate cortex, which was possibly related to response inhibition.
Estimating mean scatterer spacing with the frequency-smoothed spectral autocorrelation function

The quasiperiodicity of regularly spaced scatterers results in characteristic patterns in the spectra of backscattered ultrasonic signals from which the mean scatterer spacing can be estimated. The mean spacing has been considered for classifying certain biological tissue. This paper addresses the problem of estimating the mean scatterer spacing from backscattered ultrasound signals using the frequency-smoothed spectral autocorrelation (SAC) function. The SAC function exploits characteristic differences between the phase spectrum of the resolvable quasiperiodic scatterers and the unresolvable uniformly distributed (diffuse) scatterers to improve estimator performance over other estimators that operate directly on the magnitude spectrum. Mean scatterer spacing estimates are compared for the frequency-smoothed SAC function and a cepstral technique using an AR model. Simulation results indicate that SAC-based estimates converge more reliably over smaller amounts of data than cepstrum-based estimates. An example of computing an estimate from liver tissue scans is also presented for the SAC function and the AR cepstrum. <<ETX>>
Dose-dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists.

SCOPE Until now, the question of how the ingested doses of chlorogenic acids (CGA) from coffee influence their absorption and metabolism remains unresolved. To assess absorption in the small intestine, we performed a dose-response study with a randomized, double-blinded, crossover design with ileostomist subjects. METHODS AND RESULTS After a polyphenol-free diet, the volunteers consumed, on three separate occasions, coffee with different total CGA contents (high 4525 μmol; medium 2219 μmol; low 1053 μmol). CGA concentrations in plasma, ileal effluent, and urine were subsequently determined by HPLC-DAD-ESI-MS and -ESI-MS/MS. The results show that the consumption of higher CGA concentrations leads to a faster ileal excretion. This corresponds to a renal excretion of 8.0 ± 4.9% (high), 12.1 ± 6.7% (medium), and 14.6 ± 6.8% (low) of total CGA and metabolites. Glucuronidation of CGA became slightly greater with increasing dose. After enzyme treatment, the area under the curve (AUC)(0-8h) for CGA metabolites in plasma was 4412 ± 751 nM × h(0-8) (-1) (high), 2394 ± 637 nM × h(0-8) (-1) (medium), 1782 ± 731 nM × h(0-8) (-1) (low), respectively. Additionally, we were able to identify new metabolites of CGA in urine and ileal fluid. CONCLUSION We conclude that the consumption of high CGA concentrations via coffee might influence the gastrointestinal transit time and consequently affect CGA absorption and metabolism.
Periodicity of hermitian K-groups

Bott periodicity for the unitary, orthogonal and symplectic groups is fundamental to topological K-theory. Analogous to unitary topological K-theory, for algebraic K-groups with finite coefficients similar periodicity results are consequences of the Milnor and Bloch-Kato conjectures, affirmed by Voevodsky, Rost and others. More generally, we prove that periodicity of the algebraic K-groups for any ring implies periodicity for its hermitian K-groups, analogous to orthogonal and symplectic topological K-theory. The proofs use in an essential way higher KSC theories extending those of Anderson and Green. They also provide an upper bound for the higher hermitian K-groups in terms of the higher algebraic K-groups. We also relate periodicity to etale hermitian K-groups by proving ahermitian version of Thomason's etale descent theorem. The results are illustrated in detail for local fields, rings of integers in number fields, smooth complex algebraic varieties, rings of continuous functions on compact spaces, and group rings.
Expression and clinicopathological significance of FSIP1 in breast cancer

Aim To investigate the clinicopathological significance of the expression of fibrous sheath interacting protein 1 (FSIP1) in breast cancer, serum samples, and wound fluid from patients with breast cancer. Methods Wound fluid and serum samples from female patients with primary breast cancer, recurrent and metastatic breast cancer, and benign tumors were analyzed for FSIP1 expression using ELISA. 286 paraffin-embedded surgical specimens from breast cancer patients with at least 5 years of follow-up were included for FSIP1 expression assay using immunohistochemistry. Results Expression of FSIP1 protein was significantly higher in breast cancer tissues compared to tumor-adjacent tissues (p = 0.001). Strong correlation was observed between FSIP1 expression and human epidermal growth factor receptor 2 (Her-2) or Ki67 expression in breast cancer (p = 0.027 and 0.002, respectively). Similarly, serum level of FSIP1 was higher in patients with recurrent and metastatic breast cancer compared to that of primary breast cancer (7, 713 ± 3, 065 vs. 4, 713 ± 3, 065 pg/ml, p = 0.003). Finally, patients with high FSIP1 expression showed a worse post-operative disease-specific survival (p = 0.024). Conclusion FSIP1 may play an important role in the tumorigenesis and invasion of breast cancer and is a potential biomarker for breast cancer diagnosis or prognosis.