Miracle-dz/UniFAR-FTUs huggingface dataset:
Christian Therapists' and Clients' Perceptions of Religious Psychotherapy in Private and Agency Settings

This study investigates the work of seven mental health professionals with 27 adult clients using data from 92 sessions. Therapists were in private practice or agencies. Therapists and clients (a) identified presenting problems, (b) rated improvement in therapy since its onset, and (c) estimated severity of problems both (retrospectively) at the onset of therapy and(later) at the beginning of the study. Each week, therapists and clients reported on the use or non-use of 20 spiritual guidance techniques and rated the helpfulness of the session. Therapists saw a range of problems, most often involving marriage and family and personal-emotional concerns. Agency and private therapists saw people with different types of problems. Therapists also reported using spiritual guidance techniques at different frequencies. Therapists used spiritual guidance techniques differently with clients of differing religious intensity. Clients and therapists are cautioned that Christian therapists may differ substantially in use of spiritual guidance techniques, expertise, and therapy outcome; consequently, Christian counseling should not be treated as a unitary phenomenon.
The Spaces between Us: A Queer?Intersectional Analysis of the Narratives of Black Gay International Students.

The experiences of international students along the lines of race and ethnicity, sexuality, gender, and nationality are virtually unknown. This study utilizes experiencecentered narrative inquiry to explore the experiences of Black gay international students, and how they are racialized and sexualized in American higher education. Using a Queer and Intersectional framework, this study highlighted power structures and processes that continue to marginalize Black gay international students in the U.S. and in their home countries. Their narratives reflected significant moments or events that were important to them and how they understand their identities and realities. This study provides a strong foundation to continue the exploration of the lives of LGBTQ international students. The findings of the study offer the foundation for establishing several conclusions. It is important to note that these findings are specific and could be different if it were four other Black gay international students or varied if they attended other institutions. The findings showed that Black gay international students perform and experience their race and sexuality as connected, even in cases when they experience some dissonance due to negative experiences. The findings of the study included 1) construction of personal counter-spaces produced by resistive performances by participants 2) the problematizing race 3) tensions created by sexuality and 4) the positions within liminal national spaces.
Teachers’ Emotions in Teacher Development: Do They Matter?

This paper examines the emotions that eight teachers experienced during intervention research project on the transformation of their teaching practices. During the program which we designed, the teachers were trained to transform their teaching practices so that they would include more features of dialogic education. In this paper, we analyze data from repeated interviews with teachers who participated in our project. Based on qualitative analysis of our data, we differentiated among four groups of teachers, each with a unique self-understanding. The groups included teachers who were: perfect, eager to learn, in a good mood, and uncertain. Our paper shows that each group experienced specific emotions during the program. The only group that did not experience negative emotions was teachers in a good mood. These teachers also implemented the fewest changes in their teaching practices. Our results thus show that a lack of negative emotions limited the efficacy of teacher development.
Pharmacodynamics of Selective Androgen Receptor Modulators

The present study aimed to identify selective androgen receptor modulators (SARMs) with in vivo pharmacological activity. We examined the in vitro and in vivo pharmacological activity of four chiral, nonsteroidal SARMs synthesized in our laboratories. In the in vitro assays, these compounds demonstrated moderate to high androgen receptor (AR) binding affinity, with K i values ranging from 4 to 37 nM, and three of the compounds efficaciously stimulated AR-mediated reporter gene expression. The compounds were then administered subcutaneously to castrated rats to appraise their in vivo pharmacological activity. Androgenic activity was evaluated by the ability of these compounds to maintain the weights of prostate and seminal vesicle, whereas levator ani muscle weight was used as a measure of anabolic activity. The maximal response (E max) and dose for half-maximal effect (ED50) were determined for each compound and compared with that observed for testosterone propionate (TP). Compounds S-1 and S-4 demonstrated in vivo androgenic and anabolic activity, whereas compounds S-2 and S-3 did not. The activities of S-1 and S-4 were tissue-selective in that both compounds stimulated the anabolic organs more than the androgenic organs. These two compounds were less potent and efficacious than TP in androgenic activity, but their anabolic activity was similar to or greater than that of TP. Neither S-1 nor S-4 caused significant luteinizing hormone or follicle stimulating hormone suppression at doses near the ED50 value. Thus, compounds S-1 and S-4 were identified as SARMs with potent and tissue-selective in vivo pharmacological activity, and represent the first members of a new class of SARMs with selective anabolic effects.
Polarization of ILC2s in Peripheral Blood Might Contribute to Immunosuppressive Microenvironment in Patients with Gastric Cancer

Newly identified nuocytes or group 2 innate lymphoid cells (ILC2s) play an important role in Th2 cell mediated immunity such as protective immune responses to helminth parasites, allergic asthma, and chronic rhinosinusitis. However, the contributions of ILC2s in the occurrence and development of cancer remain unknown. Our previous study found that there was a predominant Th2 phenotype in patients with gastric cancer. In this study, the ILC2s related genes or molecules in PBMC from patients with gastric cancer were measured, and the potential correlation between them was analyzed. The expression levels of RORα, GATA3, T1/ST2, IL-17RB, CRTH2, IL-33, IL-5, and IL-4 mRNA were significantly increased in patients, but no significant changes were found in ICOS, CD45, and IL-13 expression, and there was a positive correlation between RORα or IL-13 and other related factors, such as ICOS and CD45. The increased frequency of ILC2s was also found in PBMC of patients by flow cytometry. In addition, the mRNA of Arg1 and iNOS were also significantly increased in patients. These results suggested that there are polarized ILC2s in gastric cancer patients which might contribute to immunosuppressive microenvironment and closely related to the upregulation of MDSCs and M2 macrophages.
Automorphisms of free groups have asymptotically periodic dynamics

Abstract We show that every automorphism α of a free group Fk of finite rank k has asymptotically periodic dynamics on Fk and its boundary ∂Fk : there exists a positive power α q such that every element of the compactum converges to a fixed point under iteration of α q . Further results about the dynamics of α, as well as an extension from Fk to word-hyperbolic groups, are given in the later sections.
Satellite galaxies and fossil groups in the Millennium Simulation

We use a semianalytic galaxy catalogue constructed from the Millennium Simulation(MS) to study the satellites of isolated galaxies in theCDM cosmogony. The large volume surveyed by the MS (500 3 h 3 Mpc 3 ), together with its unprecedented numerical resolution, e nable the compilation of a large sample of � 80,000 bright (Mr < 20.5) primaries, surrounded by � 178,000 satellites down to the faint magnitude limit (Mr = 17) of our catalogue. This sample allows the characterization, with minimal statistical uncertainty, of the dynam- ical properties of satellite/primary galaxy systems in aCDM universe. The details of this characterization are sensitive to the details of the modeli ng, such as its assumptions on galaxy merging and dynamical friction timescales, but many of its general predictions should be ap- plicable to hierarchical formation models such asCDM. We find that, overall, the satellite population traces the dark matter rather well: its spatial d istribution and kinematics may be approximated by an NFW profile with a mildly anisotropic velo city distribution. Their spatial distribution is also mildly anisotropic, with a well-define d "anti-Holmberg" effect that reflects the misalignment between the major axis and angular momentum of the host halo. Our anal- ysis also highlights a number of difficulties afflicting stud ies that rely on satellite velocities to constrain the primary halo mass. These arise from variations in the star formation efficiency and assembly history of isolated galaxies, which result in a scatter of up to � 2 decades in halo mass at fixed primary luminosity. Our isolation criteri on (primaries may only have com- panions at least 2 mag fainter within 1 h 1 Mpc) contributes somewhat to the scatter, since it picks not only galaxies in sparse environments, but also a number of primaries at the centre of "fossil" groups. We find that the abundance and luminosity fu nction of these unusual systems are in reasonable agreement with the few available observational constraints. Much tighter halo mass-luminosity relations are found when splitting the sample by colour: red primaries inhabit halos more than twice as massive as those surrounding blue primaries, a difference that vanishes, however, when considering stellar mass instead of luminosity. The large scat- ter in the halo mass-luminosity relation hinders the interp retation of the velocity dispersion of satellites stacked according to the luminosity of the pri mary. We find L / σ 3 (the natu- ral scaling expected forCDM) for truly-isolated primaries, i.e., systems where the central galaxy contributes more than 85% of the total luminosity within its virial radius. Less stric t primary selection, however, leads to substantial modificat ion of the scaling relation: blindly stacking satellites of all primaries results in a much shall ower L-σ relation that is only poorly approximated by a power law.
The acoustic correlates of Blackfoot prominence

Blackfoot, an Algonquian language spoken in Alberta and Montana, has been described as a pitch accent language (Frantz and Russell 1989; Frantz 1991; Kaneko 1999). Pitch accent languages mark phonetic prominence with a difference in pitch on the prominent syllable. Beckman (1986) has shown that Japanese (a prototypical pitch accent language) differs from English (a prototypical stress language) in that fundamental frequency (pitch) is the only variable that marks prominence in Japanese, whereas several variables mark prominence in English. These variables include fundamental frequency (F0) peak, amplitude peak, average amplitude, total amplitude and duration. Based on Beckman's analysis of Japanese, we would expect Blackfoot, as a pitch accent language, to mark prominence only with F0, thus patterning with Japanese. However, this analysis shows that in addition to F0, average amplitude was also correlated with prominence in Blackfoot, amplitude peak, total amplitude and duration were not. These results suggest that Blackfoot is different than Japanese in how prominence is marked. However, the results are similar enough to justify the classification of Japanese as a pitch accent language.
Animal Models That Best Reproduce the Clinical Manifestations of Human Intoxication with Organophosphorus Compounds

The translational capacity of data generated in preclinical toxicological studies is contingent upon several factors, including the appropriateness of the animal model. The primary objectives of this article are: 1) to analyze the natural history of acute and delayed signs and symptoms that develop following an acute exposure of humans to organophosphorus (OP) compounds, with an emphasis on nerve agents; 2) to identify animal models of the clinical manifestations of human exposure to OPs; and 3) to review the mechanisms that contribute to the immediate and delayed OP neurotoxicity. As discussed in this study, clinical manifestations of an acute exposure of humans to OP compounds can be faithfully reproduced in rodents and nonhuman primates. These manifestations include an acute cholinergic crisis in addition to signs of neurotoxicity that develop long after the OP exposure, particularly chronic neurologic deficits consisting of anxiety-related behavior and cognitive deficits, structural brain damage, and increased slow electroencephalographic frequencies. Because guinea pigs and nonhuman primates, like humans, have low levels of circulating carboxylesterases—the enzymes that metabolize and inactivate OP compounds—they stand out as appropriate animal models for studies of OP intoxication. These are critical points for the development of safe and effective therapeutic interventions against OP poisoning because approval of such therapies by the Food and Drug Administration is likely to rely on the Animal Efficacy Rule, which allows exclusive use of animal data as evidence of the effectiveness of a drug against pathologic conditions that cannot be ethically or feasibly tested in humans.
P-Match: transcription factor binding site search by combining patterns and weight matrices

P-Match is a new tool for identifying transcription factor (TF) binding sites in DNA sequences. It combines pattern matching and weight matrix approaches thus providing higher accuracy of recognition than each of the methods alone. P-Match is closely interconnected with the TRANSFAC® database. In particular, P-Match uses the matrix library as well as sets of aligned known TF-binding sites collected in TRANSFAC® and therefore provides the possibility to search for a large variety of different TF binding sites. Using results of extensive tests of recognition accuracy, we selected three sets of optimized cut-off values that minimize either false negatives or false positives, or the sum of both errors. Comparison with the weight matrix approaches such as Match™ tool shows that P-Match generally provides superior recognition accuracy in the area of low false negative errors (high sensitivity). As familiar to the user of Match™, P-Match also allows to save user-specific profiles that include selected subsets of matrices with corresponding TF-binding sites or user-defined cut-off values. Furthermore, a number of tissue-specific profiles are provided that were compiled by the TRANSFAC® team. A public version of the P-Match tool is available at .
Learning Knowledge from Relevant Webpage for Opinion Analysis

This paper presents an opinion analysis system based on linguistic knowledge which is acquired from small-scale annotated text and raw topic-relevant Web page. Based on the observation on the annotated opinion corpus, some word-, collocation- and sentence-level linguistic features for opinion analysis are discovered. Supervised and unsupervised learning techniques are developed to learn these features from annotated text and raw relevant Web page, respectively. These features are then incorporated into a classifier based on support vector machine (SVM) to identify opinionated sentences and determine their polarities. Evaluations show that the proposed opinion analysis system, namely OA, achieved promising performance, which shows the effectiveness of linguistic knowledge learning from relevant Web page.
Examine the Relationship between Organizational Happiness and Organizational Spirituality with Organizational Commitment in Administrators and Teachers

The aim of this study was to investigate the relationship between happiness and organizational spirituality and organizational commitment in male teachers. This research method is correlation. The study population included all male teachers and administrators of Bandar Khamir city in 2014. The study sample 105 subjects who were selected by random sampling method. Research Tools is Organizational happiness questionnaire, Spirituality in Work questionnaire and Allen and Meyer's Organizational Commitment Questionnaire. The results showed that there is a positive and significant relationship between happiness and organizational commitment.
Work-Related Maternal Risk Factors and the Risk of Pregnancy Induced Hypertension and Preeclampsia during Pregnancy. The Generation R Study

Objective To study the associations between physically demanding work and occupational exposure to chemicals and hypertensive disorders during pregnancy within a large birth cohort study, the Generation R Study. Methods Associations between occupational characteristics and hypertensive disorders during pregnancy were studied in 4465 pregnant woman participating in a population-based prospective cohort study from early pregnancy onwards in the Netherlands (2002–2006). Mothers who filled out a questionnaire during mid-pregnancy (response 77% of enrolment), were included if they conducted paid employment, had a spontaneously conceived singleton live born pregnancy, and did not suffer from pre-existing hypertension (n = 4465). Questions on physical demanding work were obtained from the Dutch Musculoskeletal Questionnaire and concerned questions on manually handling loads of 25 kg or more, long periods of standing or walking, night shifts, and working hours. To assess occupational exposure to chemicals, job titles and task descriptions were linked to a job-exposure-matrix (JEM), an expert judgment on exposure to chemicals at the workplace. Information on hypertensive disorders during pregnancy was obtained from medical records. Results We observed no consistent associations between any of the work related risk factors, such as long periods of standing or walking, heavy lifting, night shifts, and working hours, nor exposure to chemicals with hypertensive disorders during pregnancy. Conclusion This prospective birth cohort study suggests that there is no association of hypertensive disorders during pregnancy with physically demanding work or exposure to chemicals. However, the low prevalence of PIH and PE, combined with the low prevalence of occupational risk factors limit the power for inference and larger studies are needed to corroborate or refute these findings.
Re-thinking social exclusion in later life: a case for a new framework for measurement

ABSTRACT Social exclusion is a dynamic multi-dimensional process that is interactive in nature. The complex interplay between domains, whereby each domain can act as a determinant, indicator and/or outcome of social exclusion, hinders understanding of the process and the mechanisms through which social exclusion exists. This article highlights the need to disentangle these pathways and move beyond descriptive accounts of social exclusion, presenting a new working framework that allows direct hypothesis testing of these between-domain relationships. Whilst this working framework can be applied to any population, this article focuses on older adults. Life events that can drive social exclusion such as bereavement and changes in health are more likely to occur in later life, and occur more frequently, increasing the risk of social exclusion for this population. Rooted in the new working framework, this article presents the construction of later life social exclusion measures for use with Understanding Society – the United Kingdom Household Longitudinal Study. The validity of these measures are considered by examining the characteristics of those aged 65 years and over who score the highest, and therefore experience the greatest level of exclusion. This new working framework and developed social exclusion measures provide a platform from which to explore the complex relationships between domains of social exclusion and ultimately provide a clearer understanding of this intricate multi-dimensional process.
Do rapid BMI growth in childhood and early-onset obesity offer cardiometabolic protection to obese adults in mid-life? Analysis of a longitudinal cohort study of Danish men

Objective Some obese individuals have no cardiometabolic abnormalities; they are ‘metabolically healthy, but obese’ (MHO). Similarly, some non-obese individuals have cardiometabolic abnormalities, that is, ‘metabolically at risk, normal weight’ (MANW). Previous studies have suggested that early-onset obesity may be associated with MHO. We aimed to assess whether body mass index (BMI) in childhood and early-onset obesity are associated with MHO. Setting General population longitudinal cohort study, Denmark. Participants From 362 200 young men (mean age 20) examined for Danish national service between 1943 and 1977, all obese men (BMI ≥31 kg/m2, N=1930) were identified along with a random 1% sample of the others (N=3601). Our analysis includes 2392 of these men attending a research clinic in mid-life (mean age 42). For 613 of these men, data on childhood BMI are available. We summarised childhood BMI growth (7–13 years) using a multilevel model. Early-onset obesity was defined as obesity at examination for national service. Outcome measurement We defined metabolic health at the mid-life clinic as non-fasting serum cholesterol <6.6 mmol/L, non-fasting glucose <8.39 mmol/L and pulse pressure <48 mm Hg. Participants were categorised into four groups according to their obesity (BMI ≥30 kg/m2) and metabolic health in mid-life. Results 297 of 1097 (27.1%) of obese men were metabolically healthy; 826 of 1295 (63.8%) non-obese men had at least one metabolic abnormality. There was no evidence that rapid BMI growth in childhood or early-onset obesity was associated with either MHO or the MANW phenotype, for example, among obese men in mid-life, the OR for MHO comparing early-onset obesity with non-early-onset obesity was 0.97 (95% CI 0.85 to 1.10). Conclusions We found no robust evidence that early-onset obesity or rapid BMI growth in childhood is protective for cardiometabolic health.
Estimation of reliability of essay tests in public examinations.

Essay test is an indispensable part of public examinations. However, there does not seem to exist a general method that can be used to estimate its reliability in the routine operation of the examination. The aim of present research is to develop a general model to study the reliability of essay tests due to betweenmarker inconsistencies, within-marker inconsistencies and question choice. The model is making use of multilevel analysis, since data from essay tests naturally fall into a three-level hierarchy: questions within candidates and candidates within markers. For cases where only one score is available for each candidate, the three-level model would degenerate into a two-level model. Analyses using the two-level model and three-level model have been performed to illustrate how between-marker inconsistencies, factors affecting between-marker inconsistencies, within-marker systematic inconsistencies during marking period, and inconsistencies due to question choice can be analysed. By performing a common factor analysis on the covariance matrix of question scores, taking the factor score of the most dominant factor to be the true score, the reliability due to question choice and between-marker variability can be estimated. The study is illustrated by performing analyses on the question scores of the 1985 Hong Kong Advanced Level Physics Paper IIA. The data set comprises 22,544 question scores of 7,844 candidates marked by 18 markers. Parameters are estimated using iterative generalised least square. All the analyses reported in this study achieved convergence within a reasonably short time, using the software ML3E running on a personal computer, showing that the model is practicable in the routine operation of public examinations.