Miracle-dz/UniFAR-FTUs huggingface dataset:
Kiss Me Deadly: From Finnish Great Depression to Great Recession

We investigate the causes of the Finnish Great Depression, 1990-1993. We find that the collapse of the overheated financial and banking sectors starting in 1989 was the trigger of the economic crisis. Foreign shocks, which include the collapse of trade with USSR in 1991, can account for at most about half of the slump, and these shocks occurred only when the economy was already in free fall. Also, the deleveraging and restructuring process of the financial system substantially prolonged the subsequent recovery. Our methodology involves estimating a structural VAR model with sign and exogeneity restrictions. Importantly, we are able to distinguish between financial shocks affecting the demand for intermediated loans and those shifting the loan supply curve. Hence we also contribute to the discussion on which financial shocks actually matter. Keywords: business cycles, great depressions, financial shocks, sign restrictions, Finland
Representing Small Identically Self-Dual Matroids by Self-Dual Codes

The matroid associated with a linear code is the representable matroid that is defined by the columns of any generator matrix. The matroid associated with a self-dual code is identically self-dual, but it is not known whether every identically self-dual representable matroid can be represented by a self-dual code. This open problem was proposed in [R. Cramer et al., Advances in Cryptology, Lecture Notes in Comput. Sci. 3621, Springer, New York, 2005, pp. 327-343], where it was proved to be equivalent to an open problem on the complexity of multiplicative linear secret sharing schemes. Some contributions to its solution are given in this paper. A new family of identically self-dual matroids that can be represented by self-dual codes is presented. Additionally, we prove that every identically self-dual matroid on at most eight points is representable by a self-dual code.
A geometric solution to the cheap spectral factorization problem

The paper studies the cheap spectral factorization problem in the state space from a strictly geometric viewpoint. A new solution based on the geometric properties of the related Hamiltonian system is proposed and the connection between the H2-optimal model following and the spectral factorization problems is pointed out. A numerical example illustrates the theory and shows the effectiveness of the proposed solution.
Optimal Navigation for Vehicles With Stochastic Dynamics

This brief presents a framework for input-optimal navigation under state constraints for vehicles exhibiting stochastic behavior. The resulting stochastic control law is implementable in real time on vehicles with limited computational power. When control actuation is unconstrained, then convergence with probability 1 can be theoretically guaranteed. When inputs are bounded, the probability of convergence is quantifiable. The experimental implementation on a 5.5 g, 720-MHz processor that controls a bioinspired crawling robot with stochastic dynamics, corroborates the design framework.
What the Bible Says , God Says :

B. B. Warfield’s writings continue to provide a highly influential Reformed Evangelical doctrine of Scripture that is faithful to the historic Christian view of the Bible. Warfield seeks to present the Bible’s own doctrine of Scripture. His conviction that what the Bible says, God says is grounded on the plenary verbal inspiration of Scripture which guarantees its inerrancy. Particular consideration is given to the mode of inspiration and the humanity of the Bible. Following the Westminster divines, Warfield argues for the necessity, clarity, sufficiency, preservation and translation of Scripture. The Bible mediates relationship with Christ and is God speaking to the believer. The doctrine of Scripture is in some sense, or at least ought to be, foundational to all theology, and a particular approach to Scripture is one of the enduring defining characteristics of Evangelical and Reformed theology. We do well, therefore, to re-examine this fundamental doctrine especially if we aspire to be Evangelical and Reformed in our thinking. 184 ECCLESIA REFORMANDA Vol. 1, No. 2
Disaggregating pain and its effect on physical functional limitations.

BACKGROUND Pain is a common impairment that limits the abilities of older persons. The purposes of this article are to: (i) describe the distribution of pain location using the McGill Pain Map (MPM) in a community-based cohort of aged subjects; (ii) investigate whether individual areas of pain could be sensibly grouped into regions of pain; (iii) determine whether intensity, frequency, and location constitute independent dimensions of pain; and (iv) determine whether these three pain dimensions make differential contributions to the presence of self-reported physical functional limitations. METHODS A total of 833 Mexican American and European American subjects, aged 65-79 years, were enrolled in the San Antonio Longitudinal Study of Aging and were interviewed in their homes between 1992 and 1996. A total of 373 (46%) of the subjects reported having pain in the past week. Physical functional limitations were ascertained using the nine items from the Nagi scale. Three composite scales were created: upper extremity, lower extremity, and total. Pain intensity and frequency were ascertained using the McGill Pain Questionnaire. Pain location was ascertained by using the MPM. RESULTS Pain was reported in every area of the MPM. Using multiple groups confirmatory factor analysis, the 36 areas were grouped into 7 regions of pain: head, arms, hands and wrists, trunk, back, upper leg, and lower leg. Among persons with pain, pain frequency, intensity, and location were weakly associated with each other. Pain regions were primarily independent of each other, yet weak associations existed between 6 of the 21 pair-wise correlations between regions. Pain regions were differentially associated with individual physical functional limitations. Pain in the upper leg was associated with 8 of the 9 physical tasks. In multivariate analyses, age, gender, and ethnic group accounted for only 2-3% of the variance in physical tasks. In multivariate analyses, age, gender, and ethnic group accounted for only 2-3% of the variance in physical functional limitations. Pain intensity accounted for 5-6% of the variance in the composite scores of functional limitation. Pain frequency accounted for 4-5% of the variance in upper extremity limitations but did not contribute to the modeling of lower extremity limitations. In contrast, pain location accounted for 9-14% of the variance in physical functional limitations. CONCLUSIONS We tested a method for ascertaining pain location and clearly demonstrated that pain location is an important determinant of self-reported physical functional limitations. The MPM methodology may be used in population-based studies or in clinical samples that focus on specific impairments and seek to control for pain frequency and intensity. Future studies can link specific diseases with the common impairment of pain and tease out the pathways that lead to other impairments (e.g., weakness), functional limitations, and disability.
Experimental evaluation of on-board, visual mapping of an object spinning in micro-gravity aboard the International Space Station

Spacecraft proximity operations near an unknown and uncooperative and spinning target object is a challenging problem. One of the key steps in ensuring safe operations is building a map of the target object. Additionally, it is useful to estimate the relative position, orientation, linear and angular velocities of the object as well as its center of mass, principal axes of inertia and ratios of inertia so that the object's pose can be accurately propagated forward in time. This paper reviews an approach for building a map of an unknown and spinning object, and presents experimental results of this algorithm when it was run onboard the Synchronized Position Hold Engage Reorient Experimental Satellites (SPHERES) and Visual Estimation for Relative Tracking and Inspection of Generic Objects (VERTIGO) Goggles that are operating within the International Space Station. To the best of the authors' knowledge, this is the first time a solution to a Simultaneous Localization and Mapping (SLAM) problem has been run on a computer that is in space.
Heroes: What They Do and Why We Need Them

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The Emerging Nexus of Active DNA Demethylation and Mitochondrial Oxidative Metabolism in Post-Mitotic Neurons

The variable patterns of DNA methylation in mammals have been linked to a number of physiological processes, including normal embryonic development and disease pathogenesis. Active removal of DNA methylation, which potentially regulates neuronal gene expression both globally and gene specifically, has been recently implicated in neuronal plasticity, learning and memory processes. Model pathways of active DNA demethylation involve ten-eleven translocation (TET) methylcytosine dioxygenases that are dependent on oxidative metabolites. In addition, reactive oxygen species (ROS) and oxidizing agents generate oxidative modifications of DNA bases that can be removed by base excision repair proteins. These potentially link the two processes of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neurons. We review the current biochemical understanding of the DNA demethylation process and discuss its potential interaction with oxidative metabolism. We then summarise the emerging roles of both processes and their interaction in neural plasticity and memory formation and the pathophysiology of neurodegeneration. Finally, possible therapeutic approaches for neurodegenerative diseases are proposed, including reprogramming therapy by global DNA demethylation and mitohormesis therapy for locus-specific DNA demethylation in post-mitotic neurons.
Humoral Response to the Anopheles gambiae Salivary Protein gSG6: A Serological Indicator of Exposure to Afrotropical Malaria Vectors

Salivary proteins injected by blood feeding arthropods into their hosts evoke a saliva-specific humoral response which can be useful to evaluate exposure to bites of disease vectors. However, saliva of hematophagous arthropods is a complex cocktail of bioactive factors and its use in immunoassays can be misleading because of potential cross-reactivity to other antigens. Toward the development of a serological marker of exposure to Afrotropical malaria vectors we expressed the Anopheles gambiae gSG6, a small anopheline-specific salivary protein, and we measured the anti-gSG6 IgG response in individuals from a malaria hyperendemic area of Burkina Faso, West Africa. The gSG6 protein was immunogenic and anti-gSG6 IgG levels and/or prevalence increased in exposed individuals during the malaria transmission/rainy season. Moreover, this response dropped during the intervening low transmission/dry season, suggesting it is sensitive enough to detect variation in vector density. Members of the Fulani ethnic group showed higher anti-gSG6 IgG response as compared to Mossi, a result consistent with the stronger immune reactivity reported in this group. Remarkably, anti-gSG6 IgG levels among responders were high in children and gradually declined with age. This unusual pattern, opposite to the one observed with Plasmodium antigens, is compatible with a progressive desensitization to mosquito saliva and may be linked to the continued exposure to bites of anopheline mosquitoes. Overall, the humoral anti-gSG6 IgG response appears a reliable serological indicator of exposure to bites of the main African malaria vectors (An. gambiae, Anopheles arabiensis and, possibly, Anopheles funestus) and it may be exploited for malaria epidemiological studies, development of risk maps and evaluation of anti-vector measures. In addition, the gSG6 protein may represent a powerful model system to get a deeper understanding of molecular and cellular mechanisms underlying the immune tolerance and progressive desensitization to insect salivary allergens.
Developing an Area-Wide System for Coordinated Ramp Meter Control

Ramp metering has been broadly accepted and deployed as an effective countermeasure against both recurrent and non-recurrent congestion on freeways. However, many current ramp metering algorithms tend to improve only freeway travels using local detectors’ inputs and overlook the negative impacts on local streets. This may generate two problems: 1) the optimal local settings may not result in a system-wide optimum in terms of traffic operations; and 2) the increased congestion on local streets due to on-ramp overflow may counteract the gains in freeway operations. To address these problems, the authors propose an area-wide ramp metering system to improve the coordination of ramp meters for system-wide optimization and on-ramp overflow minimization. Their experimental results show that their method can offer improved performance in ramp metering operations under tested scenarios and also reduce the likelihood of on-ramp overflow. This novel strategy for active ramp metering is inspired by the principles of a computer network congestion control strategy. In this strategy, certain types of congestion at a targeted freeway location can be significantly reduced by limiting on-ramp vehicle flows to a fraction of ramp demand and then additively increasing rates to avoid ramp queue spillover onto city streets. This approach can be actively used to immediately curb the growth of traffic congestion and therefore shorten travel delays. The effectiveness of this ramp metering approach has been evaluated by microscopic simulation experiments. The authors' experimental results show that their method can reduce system-wide travel delays in the tested scenarios by as much as 28.2% when compared with the Fuzzy Logic ramp metering algorithm, and also reduce the frequency and severity of on-ramp overflow. This indicates that this area-wide algorithm can provide benefit when applied to urban freeway corridors for congestion mitigation.
Kidney Transplantation in Sensitized Recipients; A Single Center Experience

A successful transplantation, across a positive crossmatch barrier, is one of the most persistent long-standing problems in the field of kidney transplant medicine. The aim of this study was to describe seven consecutive living renal transplantations in recipients with positive crossmatch for donors or positive for donor specific antibodies (DSAs). A preconditioning regimen including plasmapheresis and intravenous immunoglobulin was delivered three times a week until the crossmatch and/or DSAs became negative. Mycophenolate mofetil and tacrolimus were started two days before the plasmapheresis. The protocol was modified to include administration of anti-CD 20 antibody (rituximab, 375 mg/m(2)) from the patient number 3 through the patient number 7. All seven patients achieved negative conversion of the crossmatch or DSAs, and the kidney transplantations were successfully performed in all cases. Acute cellular rejection occurred in two patients, which were subclinical and controlled with high dose steroid treatment. Antibody-mediated rejection occurred in one patient, which was easily reversed with plasmapheresis. All recipients attained normal graft function during the 7-24 months of follow up. Our study suggests that sensitized patients can be transplanted successfully with desensitization pretreatment.
Treatment Response and Mortality among Patients Starting Antiretroviral Therapy with and without Kaposi Sarcoma: A Cohort Study

Background Improved survival among HIV-infected individuals on antiretroviral therapy (ART) has focused attention on AIDS-related cancers including Kaposi sarcoma (KS). However, the effect of KS on response to ART is not well-described in Southern Africa. We assessed the effect of KS on survival and immunologic and virologic treatment responses at 6- and 12-months after initiation of ART. Methods We analyzed prospectively collected data from a cohort of HIV-infected adults initiating ART in South Africa. Differences in mortality between those with and without KS at ART initiation were estimated with Cox proportional hazard models. Log-binomial models were used to assess differences in CD4 count response and HIV virologic suppression within a year of initiating treatment. Results Between January 2001–January 2008, 13,847 HIV-infected adults initiated ART at the study clinics. Those with KS at ART initiation (n = 247, 2%) were similar to those without KS (n = 13600,98%) with respect to age (35 vs. 35yrs), presenting CD4 count (74 vs. 85cells/mm3) and proportion on TB treatment (37% vs. 30%). In models adjusted for sex, baseline CD4 count, age, treatment site, tuberculosis and year of ART initiation, KS patients were over three times more likely to have died at any time after ART initiation (hazard ratio[HR]: 3.62; 95% CI: 2.71–4.84) than those without KS. The increased risk was highest within the first year on ART (HR: 4.05; 95% CI: 2.95–5.55) and attenuated thereafter (HR: 2.30; 95% CI: 1.08–4.89). Those with KS also gained, on average, 29 fewer CD4 cells (95% CI: 7–52cells/mm3) and were less likely to increase their CD4 count by 50 cells from baseline (RR: 1.43; 95% CI: 0.99–2.06) within the first 6-months of treatment. Conclusions HIV-infected adults presenting with KS have increased risk of mortality even after initiation of ART with the greatest risk in the first year. Among those who survive the first year on therapy, subjects with KS demonstrated a poorer immunologic response to ART than those without KS.
Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index

Background Sleep duration may be an important regulator of body weight and metabolism. An association between short habitual sleep time and increased body mass index (BMI) has been reported in large population samples. The potential role of metabolic hormones in this association is unknown. Methods and Findings Study participants were 1,024 volunteers from the Wisconsin Sleep Cohort Study, a population-based longitudinal study of sleep disorders. Participants underwent nocturnal polysomnography and reported on their sleep habits through questionnaires and sleep diaries. Following polysomnography, morning, fasted blood samples were evaluated for serum leptin and ghrelin (two key opposing hormones in appetite regulation), adiponectin, insulin, glucose, and lipid profile. Relationships among these measures, BMI, and sleep duration (habitual and immediately prior to blood sampling) were examined using multiple variable regressions with control for confounding factors. A U-shaped curvilinear association between sleep duration and BMI was observed. In persons sleeping less than 8 h (74.4% of the sample), increased BMI was proportional to decreased sleep. Short sleep was associated with low leptin (p for slope = 0.01), with a predicted 15.5% lower leptin for habitual sleep of 5 h versus 8 h, and high ghrelin (p for slope = 0.008), with a predicted 14.9% higher ghrelin for nocturnal (polysomnographic) sleep of 5 h versus 8 h, independent of BMI. Conclusion Participants with short sleep had reduced leptin and elevated ghrelin. These differences in leptin and ghrelin are likely to increase appetite, possibly explaining the increased BMI observed with short sleep duration. In Western societies, where chronic sleep restriction is common and food is widely available, changes in appetite regulatory hormones with sleep curtailment may contribute to obesity.