Miracle-dz/UniFAR-FTUs huggingface dataset:
Are serotonin transporter knockout mice ‘depressed’?: hypoactivity but no anhedonia

Although the serotonin transporter is a key target for antidepressants, its exact role in depression etiology remains unclear. While serotonin transporter knockout mice are a potential model to examine this problem, their depression profile is unclear in several ‘despair’ tests, and may be confounded by their hypoactivity phenotype (confirmed here by marble-burying and bedding tests). To assess depression in these mice, we evaluated wild-type, heterozygous, and serotonin transporter knockout C57BL/6 male mice on a well-validated, anhedonia-based depression paradigm, the sucrose preference test. Overall, all three genotypes showed similar sucrose preference, indicating an unaltered hedonic state. These results demonstrate that depression-like behavior (unlike hypoactivity) is not a baseline phenotypic feature of serotonin transporter knockout mice, suggesting anew that these mice do not represent a genetic model of depression.
A prospective, randomized comparison of laparoscopic appendectomy with open appendectomy. Laparoscopic Appendectomy Study Group.

BACKGROUND While the advantages of laparoscopic cholecystectomy are clear, the benefits of laparoscopic appendectomy (LA) are more subtle. We conducted a randomized clinical trial to evaluate whether LA is deserving of more widespread clinical application than it has yet received. MATERIALS AND METHODS Two hundred fifty-three patients with a preoperative diagnosis of acute appendicitis were randomized into three groups. LA with an endoscopic linear stapler (LAS) (U.S. Surgical Corp., Norwalk, Connecticut) was performed on 78 patients, LA with catgut ligatures (LAL) on 89, and open appendectomy (OA) on 86. LA was performed with a three-trocar technique. OA was accomplished through a right lower-quadrant transverse incision. Data with normal distributions were analyzed by analysis of variance. Nonparametric data were analyzed with either the Kruskal-Wallis H test or Fisher's exact test. RESULTS The mean operative times for the procedures were 66 +/- 24 minutes (LAS), 68 +/- 25 minutes (LAL), and 58 +/- 27 minutes (OA). The relative brevity of OA compared to LAS and LAL was statistically significant (P < 0.01). Conversion to open procedures was approximately as frequent in the LAS group (n = 5) and the LAL (n = 6). One OA, 2 LAS, and 11 LAL patients experienced vomiting postoperatively (P < 0.05). Two intra-abdominal abscesses occurred in LAS, 4 in LAL, and 0 in OA patients (P = NS). Wound infections were more common following OA (n = 11) than LAL (n = 4) or LAS (n = 0) (P < 0.05, < 0.001). The mean length of postoperative hospital stay was 2.16 +/- 3.2 days (LAS), 2.98 +/- 2.7 days (LAL), and 2.83 +/- 1.6 (OA) (P < 0.05 OA versus LAS). The number of days patients required pain medications overall was not different between groups, but a subgroup analysis of 134 patients who rated their postoperative pain on a visual analogue scale revealed a significantly lower mean level among patients undergoing LA (LAS and LAL) versus OA (P < 0.001). Patients undergoing LA resumed regular activities sooner than those undergoing OA (9 +/- 9 days versus 14 +/- 11 days, P < 0.001). Rates of readmission to the hospital were similar for all procedures. CONCLUSIONS Laparoscopic appendectomy appears to have distinct advantages over open appendectomy. The laparoscopic procedures produced less pain and allowed more rapid return to full activities, and LAS required shorter hospital stays. The only disadvantages to the laparoscopic approach were slightly increased operative time for both procedures, and increased emesis following LAL.
Effect of Peppermint Oil on Serum Lipid Peroxidation and Hepatic Enzymes after Immobility Stress in Mice

This study was undertaken to determine the influences of various doses of peppermint oil on the hepatic en-zymes, alanine transaminase, apartate tranaminase, alkaline phosphotase and gamma glutamyl transferase and the level of malondialdehyde in the serum of mice with and without immobility stress. The mice exposed to drink water, 0.9, 27 and 60 mg/kg peppermint oil from the days 1 to 5 for a period of 4 h before and after immobility stress. Serum MDA in-creased in treatment group II, III and IV after immobility stress. There was a significant decrease in ALT in treatment group III and IV after immobility stress. There were also significant decreases in ALP and GGT in treatment group IV af-ter immobility stress. This result may suggest that, MDA level is higher in immobilization stress group than in the un-immobilized animals in serum and this results show that enzyme activities decreased after immobilization stress.
Sex differences in job attribute preferences

This study investigated the job attribute preferences of male and female MBA candidates. Participants were drawn from 27 different MBA programmes in the United States. Factor analysis of the job attributes questionnaire revealed three primary job attribute dimensions: (1) professional growth; (2) work environment; and (3) salary. Contrary to most previous research, females were found to place a greater emphasis on the professional growth dimension than did males. Males, on the other hand, placed greater emphasis on salary considerations. No sex difference was found in participants' ratings of the work environment job attribute dimension. Consistent with earlier research, women were found to place more importance on the calibre of colleagues than did males. In general, both males and females rated job attributes concerning job content as more important than job attributes concerning job context. These results are discussed with respect to earlier research findings. Finally, the generalizability of these findings to other occupational groups is discussed and managerial implications presented.
Gastrointestinal stromal tumors (GISTs) of the stomach: a multicenter, retrospective study of curatively resected gastric GISTs

Purpose The standard treatment for primary localized gastric gastrointestinal stromal tumor (GIST) is surgical resection. The clinical behavior of gastric GIST after surgical resection is extremely variable. We conducted a multicenter, retrospective study of gastric GISTs patients who underwent curative surgical resection to evaluate clinical features and the prognosis of surgically treated gastric GISTs. Methods We performed a retrospective study on 406 consecutive patients who underwent curative resections for localized gastric GIST at four university hospitals in Daegu, Korea, between March 1998 and March 2012. The retrospectively collected medical records were reviewed with respect to clinical parameters including age, gender, tumor location, surgical approach, and recurrence. Results There were 406 patients: 157 males (38.7%) and 249 females (61.3%), with a mean age of 60.8 ± 10.8 (standard deviation) years. The mean tumor size was 4.9 cm (range, 0.3-29 cm). Curative surgical resection was performed in all patients without tumor rupture or spillage. Laparoscopic wedge resections were performed in 156 patients (38.4%) and open resections in 250 patients (61.6%). The tumor size of the laparoscopic wedge resection group was smaller than that of open resection group (3.45 cm vs. 5.46 cm; P < 0.001). There were 11 recurrent cases (2.7%). No recurrence was observed in patients who underwent laparoscopic wedge resections. Conclusion Gastric GISTs had a low recurrence rate after curative resection in our series. Laparoscopic gastric wedge resection is feasible for treating gastric GISTs in selected patients.
DOES A MULTI-STAGE ULTRA-ENDURANCE RUN CAUSE DE- OR HYPER HYDRATION?

We investigated the changes in body mass and parameters of both renal function and fluid metabolism in a case study in a female ultra-endurance runner during the longest multi-stage mountain ultramarathon in Europe, the ‘Swiss Jura Marathon’ in 2008. The female ultra-runner performed the 7 stages with a total distance of 175 km, a total ascent of 5,000 m, and a total descent of 8,000 m within 23:11 h: min, finishing as second female runner. By the end of the race, body mass decreased by 0.3 kg, fat mass by 1.2 kg and skeletal muscle mass by 0.7 kg. Haemoglobin and haematocrit decreased by 4.5% and 7.5 %, respectively, and plasma volume increased by 10 %. Serum osmolality decreased by 3.3%. Parameters of myocellular damage increased substantially (CK + 630 %, LDH + 178 % and GOT + 181 %). Creatinine continuously increased in plasma (+ 23 %) and urine (+ 47 %). Creatinine clearance (– 18.7 %), glomerular filtration rate (– 19.4 %) and serum albumin (– 10.6 %) decreased. Urinary specific gravity decreased after each stage and was increased before each stage. Urinary osmolality decreased after each stage and was increased before each stage. The average daily fluid intake from stage 1 to stage 7 (during performance and rest) was 4.9 l per day. Total body water increased by 1.2 l by the end of the race. The potassium-to-sodium ratio in urine was increased after each stage. We assume that the increase in total body water was due to an increased activity in the renin-angiotensin-aldosterone-system as evidenced by the change in urinary electrolytes after the stages and an increased activity of vasopressin as evidenced by increase of urinary osmolality before the stages.
The Molecular and Physiological Responses of Physcomitrella patens to Ultraviolet-B Radiation1[W][OA]

Ultraviolet-B (UV-B) radiation present in sunlight is an important trigger of photomorphogenic acclimation and stress responses in sessile land plants. Although numerous moss species grow in unshaded habitats, our understanding of their UV-B responses is very limited. The genome of the model moss Physcomitrella patens, which grows in sun-exposed open areas, encodes signaling and metabolic components that are implicated in the UV-B response in flowering plants. In this study, we describe the response of P. patens to UV-B radiation at the morphological and molecular levels. We find that P. patens is more capable of surviving UV-B stress than Arabidopsis (Arabidopsis thaliana) and describe the differential expression of approximately 400 moss genes in response to UV-B radiation. A comparative analysis of the UV-B response in P. patens and Arabidopsis reveals both distinct and conserved pathways.
Is This a Meaningful Learning Experience? Interactive Critical Self-inquiry as Investigation

What conditions enable educators to engage in meaningful learning experiences with peers and beginning practitioners? This article documents a self-study on our actions-in-practice in a peer mentoring project. The investigation involved an iterative process to improve our knowledge as teacher educators, reflective practitioners, and researchers. Data sets included: video-stimulated reflections; audiotaped reflexive dialogue; individual and shared reflective writings. Data analyzed through the iterative process revealed competing tensions that were not addressed by the triad, leading to a less than meaningful learning experience. We sought to name the dilemmas and document how they impeded meaningful learning; identifying tensions proved useful in data interpretation. The research led us to focus on the tension between collegiality and criticality. Managing this tension requires being authentic with and accepting of the other and working with cognitive dissonances. Collegiality and criticality together promote reflexivity and increase growth, leading to new professional knowledge.
Developmental intersensory interference: Augmented prenatal sensory experience interferes with auditory learning in duck embryos.

Embryos experiencing concurrent waterbed stimulation while being exposed to a mallard maternal call failed to learn the call, whereas embryos experiencing alternating waterbed and auditory stimulation did learn the call. However, when embryos were exposed to a lower level of concurrent waterbed stimulation-one that was closer to the normal level of proximal stimulation-they were able to learn the maternal call. Thus, an augmented level of proximal stimulation that departs less significantly from the normal range does not necessarily cause intersensory interference, even if it is higher than normal, suggesting a threshold that must be exceeded to cause interference
Women Derive Collective Self-Esteem from Their Feminist Identity

Women's self-esteem is more strongly related to social acceptance and inclusion than to accomplishments. We investigated the extent to which women derive self-esteem from being women, that is, from their membership in a collective gender group. We hypothesized and found that women's collective self-esteem (i.e., self-esteem derived from their gender group) would systematically vary for women showing differing degrees of feminist development. Thus, women's self-esteem derived from womanhood seems to depend on the “meaning” of womanhood to the individual woman.
Error correction for diffraction and multiple scattering in free-space microwave measurement of materials

Metamaterials often have sharp resonances in permittivity or permeability at microwave frequencies. The sizes of the inclusions are of the order of millimeters, and this means that it is more convenient to carry out the measurement in free space. Time gating is often used in the free-space method to remove multiple scattering from the antennas and the surrounding objects. However, this lowers the resolution in the frequency domain, making it difficult to resolve the resonances reliably. Diffraction around the sample could also reduce measurement accuracy. A calibration procedure, based on the 16-term error model, which removes the need for time gating by correcting for both multiple scattering and diffraction, is developed. This procedure is tested on carbonyl iron composite and split-ring resonators, and the results are presented.
Building on the Early Years Foundation Stage: developing good practice for transition into Key Stage 1

The Independent Review of the Primary Curriculum and the independent Cambridge Primary Review both highlight the need to re‐think children's educational experiences in English classrooms between the ages of five and seven. Recent government initiatives have led to experiences in these early primary years being adult‐directed and often in whole‐class groups, with little place for the play and self‐initiated learning familiar in the Early Years Foundation Stage, which regulates education from birth to five years. This discontinuity in pedagogy has led to concerns at national and local levels. This article describes the efforts of teachers in one English local authority to develop practice in their classrooms which was less formal and teacher‐led and which responded more to the needs and interests of individual children. It describes the reasons for teacher participation in the project, the barriers that they faced and the outcomes for both teachers and children.
Patient satisfaction with maxillary 3-implant overdentures using different attachment systems opposing mandibular 2-implant overdentures.

BACKGROUND Patient-based outcomes with maxillary overdentures on a minimum number of implants, opposing mandibular 2-implant overdentures are not evident in the literature. PURPOSE To evaluate patient's satisfaction with maxillary 3-implant overdentures, opposing mandibular 2-implant overdentures, using two different attachment systems over the first 2 years of service. MATERIALS AND METHODS Forty participants wearing mandibular 2-implant overdentures for 3 years were randomly allocated to one of two similar implant system groups to receive maxillary 3-implant overdentures. Twenty participants were allocated to splinted and unsplinted attachment system treatment groups for each system. Patient satisfaction with pre-treatment complete maxillary dentures, with maxillary 3-implant overdentures at baseline and annually for 2 years, was measured using visual analogue scale questionnaires and the oral health impact profiles. Palatal coverage of the maxillary overdentures was reduced at the first annual recall. RESULTS Data showed significant improvement in pain reduction, comfort, stability, and function variables of the visual analogue scale after treatment. Analysis by prosthodontic design using visual analogue scale showed no significant difference. The total oral health impact profile-14 scores after treatment for all participants, regardless of prosthodontic design, were significantly lower (more satisfied). The overall oral health impact profile-20E score at baseline was significantly higher (more satisfied) compared with pre-treatment conventional maxillary dentures. No significant changes were observed in the first or second years compared with baseline results. Twenty-two participants (84.6%) preferred reduced palatal coverage, regardless of prosthodontic design, after 1 year. Twenty participants (76.9%) still preferred reduced palatal coverage at the end of the second year. CONCLUSIONS The provision of maxillary 3-implant overdentures to oppose mandibular 2-implant overdentures significantly improve levels of patient satisfaction compared with conventional maxillary dentures.
Contesting civil society: Reflections from El Salvador

This article assesses the recent embrace of the concept 'civil society' within development discourses, both conceptually and in the context of the construction of civil society in El Salvador. It challenges the tendency to generalise about civil society, warning against its glorification as a panacea. In a critique of the liberal approach to civil society, commonly used among international agencies, the discussion highlights how civil society organisations in El Salvador are fragmented politically, socially, but also geographically. Furthermore, civil society is not a unified entity with its constituent organisations working towards common goals. Nor may it be created or imposed from above by governments or donors. Instead it comprises a diverse range of competing groups grounded in different historical, political and geographical circumstances. While it is suggested that fostering civil society is a useful aspiration, it is essential that the concept also be recognised as contested.
Disruption of the fusion of Leishmania parasitophorous vacuoles with ER vesicles results in the control of the infection

Parasitophorous vacuoles (PV) that harbour Leishmania parasites acquire some characteristics from fusion with host cell vesicles. Recent studies have shown that PVs acquire and display resident endoplasmic reticulum (ER) molecules. We investigated the importance of ER molecules to PV biology by assessing the consequence of blocking the fusion of PVs with vesicles that originate from the early secretory pathway. This was achieved by targeting the N‐ethylmaleimide‐sensitive factor attachment protein receptors (SNAREs) that mediate the fusion of early secretory vesicles. In the presence of dominant negative variants of sec22b or some of its known cognate partners, D12 and syntaxin 18, PVs failed to distend and harboured fewer parasites. These observations were confirmed in studies in which each of the SNAREs listed above including the intermediate compartment ER/Golgi SNARE, syntaxin 5, was knocked down. The knock‐down of these SNARES had little or no measurable effect on the morphology of the ER or on activated secretion even though they resulted in a more significant reduction of PV size. Moreover, the knock‐down of the ER/Golgi SNAREs resulted in significant reduction in parasite replication. Taken together, these studies provide further evidence that PVs acquire ER components by fusing with vesicles derived from the early secretory pathway; disruption of this interaction results in inhibition of the development of PVs as well as the limitation of parasite replication within infected cells.
Death Qualification as Systematic Exclusion of Jurors With Certain Religious and Other Characteristics

The death-qualification process has been criticized because it tends to eliminate certain groups of individuals at a higher rate than others. This study examined whether the process systematically excludes jurors based on religious characteristics, justice philosophy, cognitive processing, and demographics. Results indicated that death qualification can be predicted by religious affiliation, devotionalism, fundamentalism, and Biblical interpretism; but not evangelism. Death qualification is predicted by the belief that murderers deserved to die, but not by beliefs that criminals deserve mercy, forgiveness, or payback. Cognitive processing had no impact on death qualification. Finally, gender and race predicted death qualification, while age and prior jury duty did not. These results are discussed in terms of implications for perceived legitimacy of the system. jasp_698 3218.3234
Extreme learning machine: RBF network case

A new learning algorithm called extreme learning machine (ELM) has recently been proposed for single-hidden layer feedforward neural networks (SLFNs) to easily achieve good generalization performance at extremely fast learning speed. ELM randomly chooses the input weights and analytically determines the output weights of SLFNs. This paper shows that ELM can be extended to radial basis function (RBF) network case, which allows the centers and impact widths of RBF kernels to be randomly generated and the output weights to be simply analytically calculated instead of iteratively tuned. Interestingly, the experimental results show that the ELM algorithm for RBF networks can complete learning at extremely fast speed and produce generalization performance very close to that of SVM in many artificial and real benchmarking function approximation and classification problems. Since ELM does not require validation and human-intervened parameters for given network architectures, ELM can be easily used.
The Archaeological Evidence for Social Evolution

Social evolution can be defined as the appearance of new forms of social or sociopolitical organization. In the case of the prehistoric record, such changes are perhaps most successfully studied when archaeologists collaborate with ethnologists or ethnohistorians. Although ethnologists can provide unequaled detail on agents and institutions, many evolutionary transitions took longer than any ethnologist's lifetime. The archaeological record therefore provides an important proving ground for evolutionary theory. In this review, I synthesize some of the evidence supporting social evolution from both Old World and New World archaeology. I also argue that for the study of social evolution to advance, the field of anthropology must be willing to generalize; to compare and contrast cultures from different parts of the world; and to search for common patterns in the ways human societies responded to similar challenges.