Miracle-dz/UniFAR-FTUs huggingface dataset:
When Backpressure Meets Predictive Scheduling

Motivated by the increasing popularity of learning and predicting human user behavior in communication and computing systems, in this paper, we investigate the fundamental benefit of predictive scheduling, i.e., predicting and pre-serving arrivals, in controlled queueing systems. Based on a lookahead-window prediction model, we first establish a novel queue-equivalence between the predictive queueing system with a fully efficient scheduling scheme and an equivalent queueing system without prediction. This result allows us to analytically demonstrate that predictive scheduling necessarily improves system delay performance and drives it to zero with increasing prediction power. It also enables us to exactly determine the required prediction power for different systems and study its impact on tail delay. We then propose the Predictive Backpressure (PBP) algorithm for achieving optimal utility performance in such predictive systems. PBP efficiently incorporates prediction into stochastic system control and avoids the great complication due to the exponential state space growth in the prediction window size. We show that PBP achieves a utility performance that is within O(ε) of the optimal, for any ε > 0, while guaranteeing that the system delay distribution is a shifted-to-the-left version of that under the original Backpressure algorithm. Hence, the average delay under PBP is strictly better than that under Backpressure, and vanishes with increasing prediction window size. This implies that the resulting utility-delay tradeoff with predictive scheduling can beat the known optimal [O(ε),O(log(1/ε))] tradeoff for systems without prediction. We also develop the Predictable-Only PBP (POPBP) algorithm and show that it effectively reduces packet delay in systems where traffic can only be predicted but not pre-served.
Unsupervised Word Sense Disambiguation Rivaling Supervised Methods

This paper presents an unsupervised learning algorithm for sense disambiguation that, when trained on unannotated English text, rivals the performance of supervised techniques that require time-consuming hand annotations. The algorithm is based on two powerful constraints---that words tend to have one sense per discourse and one sense per collocation---exploited in an iterative bootstrapping procedure. Tested accuracy exceeds 96%.
The Mitogenic Function of Hepatitis B Virus X Protein Resides within Amino Acids 51 to 140 and Is Modulated by N- and C-Terminal Regulatory Regions

ABSTRACT The hepatitis B virus (HBV) X protein (pX) is implicated in hepatocarcinogenesis by an unknown mechanism. pX variants encoded by HBV genomes found integrated in genomic DNA from liver tumors of patients with hepatocellular carcinoma (HCC) generally lack amino acids 134 to 154. Since deregulation of mitogenic pathways is linked to oncogenic transformation, herein we define the pX region required for mitogenic pathway activation. A series of pX deletions was used to construct tetracycline-regulated pX-expressing cell lines. The activation of the mitogenic pathways by these pX deletions expressed in the constructed cell lines was measured by transient transreporter assays, effects on endogenous cyclin A expression, and apoptosis. Conditional expression of pX51-140 in AML12 clone 4 cell line activates the mitogenic pathways, induces endogenous cyclin A expression, and sensitizes cells to apoptosis, similar to wild-type (WT) pX. By contrast, pX1-115 is inactive, supporting the idea that amino acids 116 to 140 are required for mitogenic pathway activation. Moreover, this pX deletion analysis demonstrates that WT pX function is modulated by two regions spanning amino acids 1 to 78 and 141 to 154. The N-terminal X1-78, expressed via a retroviral vector in WT pX-expressing 4pX-1 cells, coimmunoprecipitates with WT pX, indicating this pX region participates in protein-protein interactions leading to pX oligomerization. Interestingly, pX1-78 interferes with WT pX in mediating mitogenic pathway activation, endogenous gene expression, and apoptosis. The C-terminal pX region spanning amino acids 141 to 154 decreases pX stability, determined by pulse-chase studies of WT pX and pX1-140, suggesting that increased stability of naturally occurring pX variants lacking amino acids 134 to 154 may play a role in HCC development.
Overlapping Neural Systems Represent Cognitive Effort and Reward Anticipation

Anticipating a potential benefit and how difficult it will be to obtain it are valuable skills in a constantly changing environment. In the human brain, the anticipation of reward is encoded by the Anterior Cingulate Cortex (ACC) and Striatum. Naturally, potential rewards have an incentive quality, resulting in a motivational effect improving performance. Recently it has been proposed that an upcoming task requiring effort induces a similar anticipation mechanism as reward, relying on the same cortico-limbic network. However, this overlapping anticipatory activity for reward and effort has only been investigated in a perceptual task. Whether this generalizes to high-level cognitive tasks remains to be investigated. To this end, an fMRI experiment was designed to investigate anticipation of reward and effort in cognitive tasks. A mental arithmetic task was implemented, manipulating effort (difficulty), reward, and delay in reward delivery to control for temporal confounds. The goal was to test for the motivational effect induced by the expectation of bigger reward and higher effort. The results showed that the activation elicited by an upcoming difficult task overlapped with higher reward prospect in the ACC and in the striatum, thus highlighting a pivotal role of this circuit in sustaining motivated behavior.
Histological Examination of Horse Chestnut Infection by Pseudomonas syringae pv. aesculi and Non-Destructive Heat Treatment to Stop Disease Progression

Since its emergence in Northwest Europe as a pathogen that infects trunks and branches of Aesculus spp. (the horse chestnuts) approximately one decade ago, Pseudomonas syringae pv. aesculi has rapidly established itself as major threat to these trees. Infected trees exhibit extensive necrosis of phloem and cambium, which can ultimately lead to dieback. The events after host entry leading to extensive necrosis are not well documented. In this work, the histopathology of this interaction is investigated and heat-treatment is explored as method to eradicate bacteria associated with established infections. The early wound-repair responses of A. hippocastanum, both in absence and presence of P. s. pv. aesculi, included cell wall lignification by a distinct layer of phloem and cortex parenchyma cells. The same cells also deposited suberin lamellae later on, suggesting this layer functions in compartmentalizing healthy from disrupted tissues. However, monitoring bacterial ingress, its construction appeared inadequate to constrain pathogen spread. Microscopic evaluation of bacterial dispersal in situ using immunolabelling and GFP-tagging of P. s. pv. aesculi, revealed two discriminative types of bacterial colonization. The forefront of lesions was found to contain densely packed bacteria, while necrotic areas housed bacterial aggregates with scattered individuals embedded in an extracellular matrix of bacterial origin containing alginate. The endophytic localization and ability of P. s. pv aesculi to create a protective matrix render it poorly accessible for control agents. To circumvent this, a method based on selective bacterial lethality at 39°C was conceived and successfully tested on A. hippocastanum saplings, providing proof of concept for controlling this disease by heat-treatment. This may be applicable for curing other tree cankers, caused by related phytopathogens.
Reasoning about Human Participation in Self-Adaptive Systems

Self-adaptive systems overcome many of the limitations of human supervision in complex software-intensive systems by endowing them with the ability to automatically adapt their structure and behavior in the presence of runtime changes. However, adaptation in some classes of systems (e.g., Safety-critical) can benefit by receiving information from humans (e.g., Acting as sophisticated sensors, decision-makers), or by involving them as system-level effectors to execute adaptations (e.g., When automation is not possible, or as a fallback mechanism). However, human participants are influenced by factors external to the system (e.g., Training level, fatigue) that affect the likelihood of success when they perform a task, its duration, or even if they are willing to perform it in the first place. Without careful consideration of these factors, it is unclear how to decide when to involve humans in adaptation, and in which way. In this paper, we investigate how the explicit modeling of human participants can provide a better insight into the trade-offs of involving humans in adaptation. We contribute a formal framework to reason about human involvement in self-adaptation, focusing on the role of human participants as actors (i.e., Effectors) during the execution stage of adaptation. The approach consists of: (i) a language to express adaptation models that capture factors affecting human behavior and its interactions with the system, and (ii) a formalization of these adaptation models as stochastic multiplayer games (SMGs) that can be used to analyze human-system-environment interactions. We illustrate our approach in an adaptive industrial middleware used to monitor and manage sensor networks in renewable energy production plants.
Pirogoff amputation for foot trauma: an unusual amputation level: a case report.

Selecting an amputation level involves a choice between maximizing wound-healing potential and optimizing mobility and effective rehabilitation. When leg length is preserved, a patient uses less energy for walking and is more independent and mobile1-3. In 1854, the Russian surgeon Nikolay Ivanovich Pirogoff introduced a technique of foot amputation in which the heel is preserved and used as a base4,5. The forefoot, midfoot, talus, distal part of the calcaneus, and distal tibial articular cartilage are removed. The plantar skin flap is left attached to the calcaneus, which is rotated 90° dorsally to create a sensate weight-bearing surface with minimal loss of leg length, usually <5 cm (Fig. 1). Fig. 1 The amputation technique (lateral view). Since the intact heel pad creates the plantar aspect of the stump, the patient is able to bear full weight on the limb, after bone-healing has occurred, with or without a prosthesis. Pirogoff’s amputation technique and its advantages are not widely appreciated, likely because the original description was written in Russian. Modifications6-9 of the original technique have been introduced, making it difficult to aggregate individual cases. The Pirogoff technique is not suitable for everyone because of potential wound-healing problems, and it is essential that a patent posterior tibial artery be present. The technique may be most applicable for patients with a traumatic injury. Because the malleoli are left in place, they remain somewhat prominent in an otherwise cone-shaped stump, and thus a prosthesis may be worn with less friction and be more rotationally stable than the prostheses used following a standard transtibial amputation. …
Dense v.s. Sparse: A Comparative Study of Sampling Analysis in Scene Classification of High-Resolution Remote Sensing Imagery

Scene classification is a key problem in the interpretation of high-resolution remote sensing imagery. Many state-of-the-art methods, e.g. bag-of-visual-words model and its variants, the topic models as well as deep learning-based approaches, share similar procedures: patch sampling, feature description/learning and classification. Patch sampling is the first and a key procedure which has a great influence on the results. In the literature, many different sampling strategies have been used, {e.g. dense sampling, random sampling, keypoint-based sampling and saliency-based sampling, etc. However, it is still not clear which sampling strategy is suitable for the scene classification of high-resolution remote sensing images. In this paper, we comparatively study the effects of different sampling strategies under the scenario of scene classification of high-resolution remote sensing images. We divide the existing sampling methods into two types: dense sampling and sparse sampling, the later of which includes random sampling, keypoint-based sampling and various saliency-based sampling proposed recently. In order to compare their performances, we rely on a standard bag-of-visual-words model to construct our testing scheme, owing to their simplicity, robustness and efficiency. The experimental results on two commonly used datasets show that dense sampling has the best performance among all the strategies but with high spatial and computational complexity, random sampling gives better or comparable results than other sparse sampling methods, like the sophisticated multi-scale key-point operators and the saliency-based methods which are intensively studied and commonly used recently.
Mycobacterium tuberculosis Population Structures Differ Significantly on Two Indonesian Islands

ABSTRACT Comparison of Mycobacterium tuberculosis genotype distributions in different areas might help to find determinants of the emergence of certain genotypes, such as the Beijing family. In this study, M. tuberculosis isolates originating from patients from two Indonesian islands were genotyped, and possible associations with patients' characteristics and drug resistance were explored. A high degree of genetic diversity was observed among the M. tuberculosis strains, and a significant difference was found in the geographical distribution of genotype families. The predominant Beijing genotype family was isolated from 268 of 813 patients from West Java (33.0%) versus 12 of 84 patients from Timor (14.3%) (P = 0.002). Family F (East African-Indian) (33.3%) and family D (Latin American and Mediterranean) (20.0%) were more prevalent in Timor. No significant associations were found between genotype families and age, vaccination with Mycobacterium bovis BCG, previous treatment, disease localization, or drug resistance. Possible explanations for the differences in the geographical distribution of the M. tuberculosis genotypes are discussed.
Evidence for the Involvement of Testicular Protein CRISP2 in Mouse Sperm-Egg Fusion1

Abstract CRISP2, originally known as Tpx-1, is a cysteine-rich secretory protein specifically expressed in male haploid germ cells. Although likely to be involved in gamete interaction, evidence for a functional role of CRISP2 in fertilization still remains poor. In the present study, we used a mouse model to examine the subcellular localization of CRISP2 in sperm and its involvement in the different stages of fertilization. Results from indirect immunofluorescence and protein extraction experiments indicated that mouse CRISP2 is an intraacrosomal component that remains associated with sperm after capacitation and the acrosome reaction (AR). In vitro fertilization assays using zona pellucida-intact mouse eggs showed that an antibody against the protein significantly decreased the percentage of penetrated eggs, with a coincident accumulation of perivitelline sperm. The failure to inhibit zona pellucida penetration excludes a detrimental effect of the antibody on sperm motility or the AR, supporting a specific participation of CRISP2 at the sperm-egg fusion step. In agreement with this evidence, recombinant mouse CRISP2 (recCRISP2) specifically bound to the fusogenic area of mouse eggs, as previously reported for rat CRISP1, an epididymal protein involved in gamete fusion. In vitro competition investigations showed that incubation of mouse zona-free eggs with a fixed concentration of recCRISP2 and increasing amounts of rat CRISP1 reduced the binding of recCRISP2 to the egg, suggesting that the proteins interact with common complementary sites on the egg surface. Our findings indicate that testicular CRISP2, as observed for epididymal CRISP1, is involved in sperm-egg fusion through its binding to complementary sites on the egg surface, supporting the idea of functional cooperation between homologous molecules to ensure the success of fertilization.
Locoregional Recurrence of Breast Conserving Surgery after Preoperative Chemotherapy in Korean Women with Locally Advanced Breast Cancer

Purpose Preoperative chemotherapy has been used to increase the rate of breast conserving surgery (BCS) in Caucasian women. However, whether it would also increase the rate of BCS in Korean women has not been verified. The aim of this study was to determine the effectiveness of preoperative chemotherapy to make BCS possible in Korean women who have locally advanced cancer without any increase of locoregional recurrence according to operation methods (BCS vs. mastectomy). Methods From August 2002 to April 2005, 205 patients with stage II or III breast cancer were enrolled in a phase III randomized trial of preoperative chemotherapy. Surgeons decided on the type of surgery (mastectomy or BCS) at initial diagnosis. By randomization, patients received four cycles of either docetaxel/capecitabine or doxorubicin/cyclophosphamide followed by surgery and crossover to the other treatment as postoperative chemotherapy. Results The mean tumor size was 3.29 cm and the mean breast volume was 489 cc at diagnosis. After preoperative chemotherapy, clinical response was shown in 76.0% of the patients. Of the 71 patients planned for a mastectomy at initial diagnosis, 27 patients underwent BCS (38.0%). Clinical T stage after preoperative chemotherapy, pathologic T size and lymphatic invasion were correlated with conversion to BCS. In multivariate analysis, only lymphatic invasion showed statistical significance. Locoregional disease-free survival did not statistically differ between the two operation methods for the patients who were planned for a mastectomy at the initial exam. Conclusion This study showed that preoperative chemotherapy also increased the rate of BCS, while avoiding any increase of locoregional recurrence in Korean women with locally advanced breast cancer.
DSM-IV diagnosed posttraumatic stress disorder in women veterans with and without military sexual trauma

AbstractBACKGROUND: This study compares rates of post-traumatic stress disorder (PTSD) in female veterans who had military sexual trauma (MST) with rates of PTSD in women veterans with all other types of trauma. METHODS: Subjects were recruited at the Women’s Comprehensive Healthcare Center when attending medical or psychiatric appointments or through a mailing; 230 women agreed and 196 completed the study. They completed questionnaires on health and military history, along with the Stressful Life Events Questionnaire (SLEQ). Those who met DSM-IV PTSD Criterion A completed the PTSD Symptom Scale-Interview (PSS-I) on which PTSD diagnoses were based. RESULTS: Ninety-two percent reported at least 1 trauma. Forty-one percent had MST, alone or with other trauma, and 90% had other trauma, with or without MST. Overall, 43% of subjects with trauma had PTSD. Those with MST had higher rates of PTSD than those with other trauma. Sixty percent of those with MST had PTSD; 43% of subjects with other traumas (with or without MST) had PTSD. Military sexual trauma and other trauma both significantly predicted PTSD in regression analyses (P=.0001 and .02, respectively) but MST predicted it more strongly. Prior trauma did not contribute to the relationship between MST and PTSD. DISCUSSION: Findings suggest that MST is common and that it is a trauma especially associated with PTSD.
Noradrenaline Triggers GABAA Inhibition of Bed Nucleus of the Stria Terminalis Neurons Projecting to the Ventral Tegmental Area

The lateral part of the ventral bed nucleus of the stria terminalis (vlBNST) is a critical site for the antiaversive effects of noradrenergic drugs during opioid withdrawal. The objective of the present study is to identify the cellular action(s) of noradrenaline in the vlBNST after withdrawal froma5d treatment with morphine. The vlBNST is a heterogeneous cell group with multiple efferent projections. Therefore, neurons projecting to the midbrain were identified by retrograde transport of fluorescent microspheres injected in the ventral tegmental area (VTA). Whole-cell voltage clamp recordings of these neurons and of those sharing physiological properties were done in brain slices. Noradrenaline activated α1-adrenergic receptors to increase GABAA-IPSC frequency. Noradrenaline produced a similar increase in GABAA-IPSCs during acute opioid withdrawal, but this increase resulted from activation ofβ-adrenergic receptors, adenylyl cyclase, and protein kinase A, as well as α1-adrenergic receptors. Given that neurons in the vlBNST send an excitatory projection to the VTA, noradrenaline may reduce excitatory drive to mesolimbic dopamine cells. This mechanism might contribute to the withdrawal-induced inhibition of dopamine neurons and explain how noradrenergic drugs microinjected into the vlBNST reduce aversive aspects of opioid withdrawal.
Efficiency of energy and protein deposition in swine measured by dual energy X-ray absorptiometry (DXA)

Abstract. A series of studies were conducted using dual energy X-ray absorptiometry (DXA) to measure energy and protein deposition in pigs. In an initial validation study DXA was compared directly with slaughter analysis as a method for measuring energy deposition in pigs. During growth from 30 to 60 kg the mean value for carcass energy deposition measured by DXA was 251 MJ compared to 249 MJ by chemical analysis (R 2 =0.94). Subsequently it was shown that both compensatory growth and the addition of ractopamine to the diet resulted in an improvement in efficiency of protein deposition (PE), however, ractopamine also resulted in a reduction in the efficiency of energy deposition (k g ). Another study was conducted to compare the efficiency of utilization of dietary energy and protein by control and IGF-I transgenic pigs in response to dietary conjugated linoleic acid (CLA). Addition of CLA to the diet resulted in a reduction in k g , though there was no difference in k g based on genotype or sex. The PE was higher (P NN ), heterozygous ( Nn ) or homozygous stress sensitive ( nn ). During growth from 30 to 60 kg or 60 to 90 kg there were no differences in the efficiency of either energy or protein deposition. In conclusion, DXA can be used to replace the comparative slaughter technique for measuring energy and protein deposition in pigs, thus this approach is useful for identifying differences in energy and protein deposition in pigs of different genotypes or when subjected to various dietary treatments.
Adaptive Dissection Based Subword Segmentation of Printed Arabic Text

Numerous segmentation and recognition techniques have been proposed in literature for Arabic OCR system. Correct and efficient segmentation of Arabic text into characters is considered to be a fundamental problem. While OCR systems for other languages do not need segmentation for printed text for successful recognition, it is essential to design robust and powerful segmentation algorithms or employ segmentation free recognition schemes for printed Arabic text. Even more, in recognition of handwritten characters, segmentation is considered to be indispensable. Most of current segmentation technique suffers from over segmentation and under segmentation in addition to not being adaptive in nature. In this paper, we have proposed a new sub-word segmentation scheme, which is independent of font size and font type.