Miracle-dz/UniFAR-FTUs huggingface dataset:
SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity

Persistent infections by sedentary plant-parasitic nematodes are a major threat to important food crops all over the world. These roundworms manipulate host plant cell morphology and physiology to establish sophisticated feeding structures. Key modifications to plant cells during their transition into feeding structures are largely attributed to the activity of effectors secreted by the nematodes. The SPRYSEC effectors were initially identified in the potato cyst nematodes Globodera rostochiensis and G. pallida, and are characterized by a single SPRY domain, a non-catalytic domain present in modular proteins with different functions. The SPRY domain is wide-spread among eukaryotes and thought to be involved in mediating protein–protein interactions. Thus far, the SPRY domain is only reported as a functional domain in effectors of plant-parasitic nematodes, but not of other plant pathogens. SPRYSEC effectors have been implicated in both suppression and activation of plant immunity, but other possible roles in nematode virulence remain undefined. Here, we review the latest reports on the structure, function, and sequence diversity of SPRYSEC effectors, which provide support for a model featuring these effectors as a versatile protein-binding platform for the nematodes to target a wide range of host proteins during parasitism.
Robust $H_{\infty}$  Filtering for Time-Delay Systems With Probabilistic Sensor Faults

In this paper, a new robust H infin filtering problem is investigated for a class of time-varying nonlinear system with norm-bounded parameter uncertainties, bounded state delay, sector-bounded nonlinearity and probabilistic sensor gain faults. The probabilistic sensor reductions are modeled by using a random variable that obeys a specific distribution in a known interval [alpha,beta], which accounts for the following two phenomenon: 1) signal stochastic attenuation in unreliable analog channel and 2) random sensor gain reduction in severe environment. The main task is to design a robust H infin filter such that, for all possible uncertain measurements, system parameter uncertainties, nonlinearity as well as time-varying delays, the filtering error dynamics is asymptotically mean-square stable with a prescribed H infin performance level. A sufficient condition for the existence of such a filter is presented in terms of the feasibility of a certain linear matrix inequality (LMI). A numerical example is introduced to illustrate the effectiveness and applicability of the proposed methodology.
Translations of new public management: a decentred approach to school governance in four OECD countries

ABSTRACT Despite the prevalence of corporate and performative models of school governance within and across different education systems, there are various cases of uneven, hybrid expressions of New Public Management (NPM) that reveal the contingency of global patterns of rule. Adopting a ‘decentred approach’ to governance (Bevir, M. 2010. “Rethinking Governmentality: Towards Genealogies of Governance.” European Journal of Social Theory 13 (4): 423–441), this paper compares the development of NPM in four OECD countries: Australia, England, Spain, and Switzerland. A focus of the paper is how certain policy instruments are created and sustained within highly differentiated geo-political settings and through different multi-scalar actors and authorities yet modified to reflect established traditions and practices.
Green Synthesis of Silver Nanoparticles Using Pinus eldarica Bark Extract

Recently, development of reliable experimental protocols for synthesis of metal nanoparticles with desired morphologies and sizes has become a major focus of researchers. Green synthesis of metal nanoparticles using organisms has emerged as a nontoxic and ecofriendly method for synthesis of metal nanoparticles. The objectives of this study were production of silver nanoparticles using Pinus eldarica bark extract and optimization of the biosynthesis process. The effects of quantity of extract, substrate concentration, temperature, and pH on the formation of silver nanoparticles are studied. TEM images showed that biosynthesized silver nanoparticles (approximately in the range of 10–40 nm) were predominantly spherical in shape. The preparation of nano-structured silver particles using P. eldarica bark extract provides an environmentally friendly option, as compared to currently available chemical and/or physical methods.
Mechanical Characterization of Aluminium Silicon Carbide Composite

Conventional materials like Steel, Brass, Aluminium etc will fail without any indication. Cracks initiation, propagation will takes place with in a short span. Now a day to overcome this problem, conventional materials are replaced by Aluminium alloy materials. Aluminium alloy materials found to the best alternative with its unique capacity of designing the materials to give required properties. In this paper tensile strength experiments have been conducted by varying mass fraction of SiC (5%, 10%, 15%, and 20%) with Aluminium. The maximum tensile strength has been obtained at 15% SiC ratio. Mechanical and Corrosion behavior of Aluminium Silicon Carbide alloys are also studied.
What Fraction of Stock Option Grants to Top Executives Have Been Backdated or Manipulated?

We estimate that 13.6% of all option grants to top executives during the period 1996--2005 were backdated or otherwise manipulated. Our study primarily focuses on grants that were unscheduled and at-the-money, of which we estimate that 18.9% were manipulated. The fraction is 23.0% before the new two-day filing requirement took effect on August 29, 2002, and 10.0% afterward. For the minority of grants that are not filed within the required two-day window, the fraction of manipulated grants remains as high as 19.9%. We further find a higher frequency of manipulation among tech firms, small firms, and firms with high stock price volatility. In addition, firms that use smaller (non-big-five) auditing firms are more likely to file their grants late. Finally, at the firm level, we estimate that 29.2% of firms manipulated grants to top executives at some point between 1996 and 2005.
Small renal masses in the elderly: Contemporary treatment approaches and comparative oncological outcomes of nonsurgical and surgical strategies

Over the last decades, there has been a significant stage migration in renal cell carcinoma and especially older patients are getting diagnosed more frequently with low stage disease, such as small renal masses ≤4 cm of size. Considering the particular risk profile of an older population, often presenting with a nonnegligible comorbidity profile and progressive renal dysfunction, treatment approaches beyond aggressive radical surgical procedures have come to the fore. We sought to give a contemporary overview of the available different treatment strategies for incidental small renal masses in an elderly population with the focus on comparative oncological outcomes of nonsurgical and surgical modalities.
Scikit-learn: Machine Learning Without Learning the Machinery

Machine learning is a pervasive development at the intersection of statistics and computer science. While it can benefit many data-related applications, the technical nature of the research literature and the corresponding algorithms slows down its adoption. Scikit-learn is an open-source software project that aims at making machine learning accessible to all, whether it be in academia or in industry. It benefits from the general-purpose Python language, which is both broadly adopted in the scientific world, and supported by a thriving ecosystem of contributors. Here we give a quick introduction to scikit-learn as well as to machine-learning basics.
Modeling and Verification for Cross-Department Collaborative Business Processes Using Extended Petri Nets

Recently, cross-department business processes are becoming more and more complex. Different kinds of coordination patterns exist among different departments, which make modeling and analysis work more difficult. To our best knowledge, there is no formal method to give systematic modeling and verification for the cross-department processes when considering different kinds of coordination patterns among different departments. This paper proposes such a method based on Petri nets. The WF-net model extended with resource and message factors, RM_WF_Net for short, is first introduced. Then, the formal model of tasks is proposed and its coordination relations are given. Next, RM_WF_Net modeling for intradepartment processes is investigated and cross-department coordination patterns, including message interaction pattern, resource interaction pattern, task collaboration pattern, procedure abstract, service outsourcing pattern, and process activation pattern, are formally defined. The soundness of the RM_WF_Net is verified based on the reachability graph. A running case of the cross-department medical diagnosis business process is given to validate our proposed method.
2D Gaze Estimation Based on Pupil-Glint Vector Using an Artificial Neural Network

Gaze estimation methods play an important role in a gaze tracking system. A novel 2D gaze estimation method based on the pupil-glint vector is proposed in this paper. First, the circular ring rays location (CRRL) method and Gaussian fitting are utilized for pupil and glint detection, respectively. Then the pupil-glint vector is calculated through subtraction of pupil and glint center fitting. Second, a mapping function is established according to the corresponding relationship between pupil-glint vectors and actual gaze calibration points. In order to solve the mapping function, an improved artificial neural network (DLSR-ANN) based on direct least squares regression is proposed. When the mapping function is determined, gaze estimation can be actualized through calculating gaze point coordinates. Finally, error compensation is implemented to further enhance accuracy of gaze estimation. The proposed method can achieve a corresponding accuracy of 1.29°, 0.89°, 0.52°, and 0.39° when a model with four, six, nine, or 16 calibration markers is utilized for calibration, respectively. Considering error compensation, gaze estimation accuracy can reach 0.36°. The experimental results show that gaze estimation accuracy of the proposed method in this paper is better than that of linear regression (direct least squares regression) and nonlinear regression (generic artificial neural network). The proposed method contributes to enhancing the total accuracy of a gaze tracking system.
Structure of the Sardinia Channel: crustal thinning and tardi-orogenic extension in the Apenninic-Maghrebian orogen; results of the Cyana submersible survey (SARCYA and SARTUCYA) in the western Mediterranean

The Sardinia Channel is located in a 400 km-long submerged section of the Apennine-Maghrebian branch of the Alpine chain. The Sardinia Channel connects the Algerian-Ligurian-Provencal to the Tyrrhenian oceanic basins. The structure of this region results from the superposition of two tectonic regimes: an earlier crustal thickening and a later crustal thinning. The crustal thickening is the consequence of the shortening which occurred in the late Oligocene-early Miocene during the build up of the Apennine-Maghrebian Orogen. This thickening is coeval with the rotation of the Corsican-Sardinian block and the opening of the Provencal-Algerian back-arc basin. All of these structures, as well as the magmatic arcs in Sardinia and Tunisia, i.e. the Galite Archipelago, are connected to the subduction of the Tethyan Ocean. The crustal thinning is associated with the rifting of the Tyrrhenian Basin, which occurred just before the Messinian salinity crisis and was accompanied by significant erosion throughout the region. This erosion was followed by a period of thermal subsidence linked to the opening of the Tyrrhenian oceanic basin in the Plio-Quaternary, interspersed with minor episodes of compression. On the Sardinian margin, the dives led to the discovery of a submarine volcano, dated at 12.6 Ma, and composed of shoshonitic andesites with lamprophyre inclusions, and to the characterization of the nature and structure of the underlying basement, consisting of tilted blocks of Hercynian metamorphic and granitic rocks and their sedimentary cover. The sea floor morphology reflects this structure. The other areas of the Sardinia Channel explored, i.e. its southern margin and central ridge, belong to the Calabrian-Peloritanian-Kabylian group (CPK). They are composed of a metamorphic and granitic Hercynian basement deformed during the Alpine orogeny, which is stratigraphically overlain by an Oligo-Miocene detrital cover of Peloritanian or Kabylian type, and tectonically overlain by the so-called "flysch nappe". Throughout the CPK domain these formations were subjected during the Oligo-Miocene, at ca. 23 Ma ago, to a first denudation event, and during the Tortonian, ca. 10-8 Ma ago, to a second denudation, which has been connected to the opening of the Tyrrhenian basin. Structures, microstructures and thermochronological data indicate relatively low P-T conditions for the extensional deformations: this suggests that these units remained at shallow depths in the Apennine-Maghrebian Orogen, and were relatively preserved from the Messinian erosion. The age (12.5 Ma) and nature of the volcanic sequence in the Sorelles is closely comparable with the calc-alkaline suite of the Galite Archipelago, Tunisia. Thus, the data gathered during the dives in the Sardinia Channel give new constraints to the reconstruction of the kinematic evolution not only of the region, but also to the entire western Mediterranean.
Why disgust matters

The new synthesis about disgust is that it is a system that evolved to motivate infectious disease avoidance. There are vital practical and intellectual reasons why we need to understand disgust better. Practically, disgust can be harnessed to combat the behavioural causes of infectious and chronic disease such as diarrhoeal disease, pandemic flu and smoking. Disgust is also a source of much human suffering; it plays an underappreciated role in anxieties and phobias such as obsessive compulsive disorder, social phobia and post-traumatic stress syndromes; it is a hidden cost of many occupations such as caring for the sick and dealing with wastes, and self-directed disgust afflicts the lives of many, such as the obese and fistula patients. Disgust is used and abused in society, being both a force for social cohesion and a cause of prejudice and stigmatization of out-groups. This paper argues that a better understanding of disgust, using the new synthesis, offers practical lessons that can enhance human flourishing. Disgust also provides a model system for the study of emotion, one of the most important issues facing the brain and behavioural sciences today.
On the effect of the cosmological expansion on the gravitational lensing by a point mass

We analyze the effect of the cosmological expansion on the deflection of light caused by a point mass, adopting the McVittie metric as the geometrical description of a pointlike lens embedded in an expanding universe. In the case of a generic, non-constant Hubble parameter $H$ we derive and approximately solve the null geodesic equations, finding an expression for the bending angle $\delta$, which we expand in powers of the mass-to-closest approach distance ratio and of the impact parameter-to-lens distance ratio. It turns out that the leading order of the aforementioned expansion is the same as the one calculated for the Schawarzschild metric and that cosmological corrections contribute to $\delta$ only at sub-dominant orders. We explicitly calculate these cosmological corrections for the case of $H$ constant and find that they provide a correction of order $10^{-11}$ on the lens mass estimate.
Role of prostaglandin E2 in bacterial growth in women with endometriosis.

STUDY QUESTION Can prostaglandin E(2) (PGE(2)) in menstrual and peritoneal fluid (PF) promote bacterial growth in women with endometriosis? SUMMARY ANSWER PGE(2) promotes bacterial growth in women with endometriosis. WHAT IS KNOWN ALREADY Menstrual blood of women with endometriosis is highly contaminated with Escherichia coli (E. coli) compared with that of non-endometriotic women: E. coli-derived lipopolysaccharide (LPS) promotes the growth of endometriosis. STUDY DESIGN, SIZE AND DURATION Case-controlled biological research with a prospective collection of body fluids and endometrial tissues from women with and without endometriosis with retrospective evaluation. PARTICIPANTS/MATERIALS, SETTING AND METHODS PF and sera were collected from 58 women with endometriosis and 28 women without endometriosis in an academic research laboratory. Menstrual blood was collected from a proportion of these women. Macrophages (Mφ) from PF and stromal cells from eutopic endometria were isolated in primary culture. The exogenous effect of PGE(2) on the replication of E. coli was examined in a bacterial culture system. Levels of PGE(2) in different body fluids and in the culture media of Mφ and stromal cells were measured by ELISA. The effect of PGE(2) on the growth of peripheral blood lymphocytes (PBLs) was examined. MAIN RESULTS AND THE ROLE OF CHANCE The PGE(2) level was 2-3 times higher in the menstrual fluid (MF) than in either sera or in PF. A significantly higher level of PGE(2) was found in the MF and PF of women with endometriosis than in control women (P < 0.05 for each). Exogenous treatment with PGE(2) dose dependently increased E. coli colony formation when compared with non-treated bacteria. PGE(2)-enriched MF was able to stimulate the growth of E. coli in a dilution-dependent manner; this effect was more significantly enhanced in women with endometriosis than in control women (P < 0.05). PGE(2) levels in the culture media of LPS-treated Mφ/stromal cells were significantly higher in women with endometriosis than in non-endometriosis (P < 0.05 for each). Direct application of PGE(2) and culture media derived from endometrial Mφ or stromal cells significantly suppressed phytohemagglutinin-stimulated growth of PBLs. LIMITATIONS AND REASONS FOR CAUTION Further studies are needed to examine the association between PGE(2)-stimulated growth of E. coli and endotoxin level and to investigate the possible occurrence of sub-clinical infection within vaginal cavity. WIDER IMPLICATIONS OF THE FINDINGS Our findings may provide some new insights to understand the physiopathology or pathogenesis of the mysterious disease endometriosis and may hold new therapeutic potential. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by grants-in-aid for Scientific Research from the Ministry of Education, Sports, Culture, Science and Technology of Japan. There is no conflict of interest related to this study. TRIAL REGISTRATION NUMBER Not applicable.
Light and Electron Microscopy of the European Beaver (Castor fiber) Stomach Reveal Unique Morphological Features with Possible General Biological Significance

Anatomical, histological, and ultrastructural studies of the European beaver stomach revealed several unique morphological features. The prominent attribute of its gross morphology was the cardiogastric gland (CGG), located near the oesophageal entrance. Light microscopy showed that the CGG was formed by invaginations of the mucosa into the submucosa, which contained densely packed proper gastric glands comprised primarily of parietal and chief cells. Mucous neck cells represented <0.1% of cells in the CGG gastric glands and 22–32% of cells in the proper gastric glands of the mucosa lining the stomach lumen. These data suggest that chief cells in the CGG develop from undifferentiated cells that migrate through the gastric gland neck rather than from mucous neck cells. Classical chief cell formation (i.e., arising from mucous neck cells) occurred in the mucosa lining the stomach lumen, however. The muscularis around the CGG consisted primarily of skeletal muscle tissue. The cardiac region was rudimentary while the fundus/corpus and pyloric regions were equally developed. Another unusual feature of the beaver stomach was the presence of specific mucus with a thickness up to 950 µm (in frozen, unfixed sections) that coated the mucosa. Our observations suggest that the formation of this mucus is complex and includes the secretory granule accumulation in the cytoplasm of pit cells, the granule aggregation inside cells, and the incorporation of degenerating cells into the mucus.
Stellar populations in the nuclear regions of nearby radio galaxies

ABSTRACT We present optical spectra of the nuclei of seven luminous (P 178MHz >∼10 25 W Hz −1 Sr ) nearby (z < 0.08) radiogalaxies, which mostly correspond tothe FR II class. In two cases, Hydra A and 3C 285, the Balmer and λ4000˚A breakindices constrain the spectral types and luminosity classes of the stars involved, re-vealing that the blue spectra are dominated by blue supergiant and/or giant stars.The ages derived for the last burst of star formation in Hydra A are between 7 and40 Myr, and in 3C 285 about 10 Myr. The rest of the narrow-line radiogalaxies (four)have λ4000˚A break and metallic indices consistent with those of ellipt ical galaxies.The only broad-line radiogalaxy in our sample, 3C 382, has a strong featureless bluecontinuum and broad emission lines that dilute the underlying blue stellar spectra.We are able to detect the Ca II triplet in absorption in the seven objects, with goodquality data for only four of them. The strengths of the absorptions are similar tothose found in normal elliptical galaxies, but these values are both consistent withsingle stellar populations of ages as derived from the Balmer absorption and breakstrengths, and, also, with mixed young+old populations.Key words: galaxies: active – galaxies: starbursts – galaxies: stellar content
How Do Primary Care Physicians Perceive the Role of Nurses in Quality Measurement and Improvement? The Israeli Story

Background Israel has boasted a highly effective national quality monitoring program for community-based health services since 2004. The program involves ongoing monitoring of the quality of selected services provided by Israeli health plans and includes approximately 70 indicators. Objective To analyze Israeli primary care physicians’ (PCPs) perceptions of nurses’ roles in the national quality monitoring program and their contribution to improving health-care quality. Design A cross sectional survey using self-reported questionnaire. Setting Four Israeli health plans, covering 100% of the Israeli population. Participants A representative sample of 1,000 Israeli PCPs. Response rate of 69% (605 out of the 884 physicians who met the study criteria). Methods A questionnaire combined with closed questions on the attitudes and behaviors of the physicians regarding nurses’ involvement in quality monitoring and open questions about the changes that had made in their practice as a result of the quality monitoring program. Results Most respondents (74%) agreed that nurses contribute to practice quality and share responsibility for improving quality measures. Physicians who felt that quality monitoring improved the quality of care and those who supported the program were more likely to consider that nurses shared responsibility for the quality of care. However, in open-ended questions about the changes they made in their practices as a result of the program, they made minimal reference to the importance of nurses and their contribution to improved quality indicators. Conclusion There was a disparity between the closed-ended and open-ended questions regarding the way physicians depicted the role of nurses in quality monitoring and improvement. This disparity may be due to the fact that physicians do not yet fully appreciate the growing involvement of nurses in these areas.