Miracle-dz/UniFAR-FTUs huggingface dataset:
Circulating microRNAs: novel biomarkers for cardiovascular diseases?

This editorial refers to ‘Circulating microRNAs are new and sensitive biomarkers of myocardial infarction? [†][1], by Y. D'Alessandra et al. , on page 2765 MicroRNAs (miRNAs) comprise short, non-coding RNAs, which are important for many aspects of homeostasis and disease.1,2 MiRNAs are generally considered to act as intracellular endogenous RNAs to control gene expression on a post-translational level. However, recent studies demonstrated that miRNA can be detected in circulating blood and that these circulating miRNAs might be useful disease biomarkers, e.g. for certain forms of cancer.3,4 D'Alessandra and colleagues have now demonstrated that circulating muscle-derived miRNAs might be useful as biomarkers of acute myocardial infarction (AMI)5 ( Figure 1A ). Specifically, the authors showed that muscle-enriched miRNAs, such as miR-1, miR-133a, miR-133b, and miR-499-5p, are elevated in plasma obtained from mice after coronary artery ligation as well as in humans with AMI.5 In line with these findings, other groups recently reported similar results.6,7 In experimental AMI models and in patients, Wang et al. showed that the muscle-enriched miR-1, miR-133a and miR-499 as well as the cardiac-specific miR-208 are elevated in plasma.6 Likewise, miR-499,7 miR-1,8,9 miR-133a/b, and miR-2089 were shown to be increased in small cohorts of humans after AMI. All of these studies suggest that circulating myocardial-derived miRNAs … *Corresponding author. Tel: +49 69 6301 5158, Fax: +49 69 6301 7113, Email: Dimmeler{at}em.uni-frankfurt.de [1]: #fn-2
The relation between math self-concept, test and math anxiety, achievement motivation and math achievement in 12 to 14-year-old typically developing adolescents

espanolEn este estudio se examino la relacion entre el auto concepto matematico, la ansiedad ante los examenes en matematicas, la motivacion de logro y el rendimiento matematico en adolescentes de desarrollo estandar (N = 108) de 12 a 14 anos de un centro de educacion secundaria en Holanda. Los datos fueron obtenidos a partir de una prueba de velocidad de resolucion matematica, un test de motivacion de logro y un cuestionario sobre su experiencia con las matematicas. Se encontro una correlacion positiva entre el auto concepto matematico y los resultados en matematicas en los cuatro dominios evaluados (medidas, relaciones, numeracion y escalas), asi como con las habilidades matematicas automatizadas. Igualmente se encontraron correlaciones negativas significativas entre la ansiedad ante las matematicas y los resultados en esta materia para las tareas de escalas. La ansiedad matematica no resulto ser un mediador en la correlacion entre auto concepto matematico y los resultados en matematicas. Tampoco se encontro correlacion entre motivacion de logro, la ansiedad ante los examenes y los resultados en matematicas. El analisis de regresion indico que el autoconcepto matematico fue la unica variable que explicaba una proporcion significativa de la varianza en los resultados en matematicas. Teniendo en cuenta estos datos, se sugiere que la estimulacion de creencias y sentimientos positivos de los estudiantes sobre su propia competencia en matematicas, puede mejorar el rendimiento en esta materia. espanolThis study examines the relation between math self-concept, test and math anxiety, achievement motivation, and math achievement in typically developing 12 to 14-year-old adolescents (N = 108) from a school for secondary education in the Netherlands. Data was obtained using a math speed test, achievement motivation test, and the math experience questionnaire. A significant positive correlation was found between math self-concept and math achievement in all four math domains (measurement, relations, numbers, and scale), as well as automatized math skills. Furthermore, there was a significant negative correlation between math anxiety and math achievement in the math domain “scale”. Math anxiety was not a mediator in the correlation between math self-concept and math achievement. There was no correlation between achievement motivation, test anxiety, and math achievement. Regression analyses indicated that math self-concept was the only variable that accounted for a significant unique proportion of variance in math scores. Together, these results suggest that stimulating positive feelings and beliefs of students in their own competence in math may lead to better math achievement.
Global Asmptotic Stability for Systems with Friction and Input Backlash

Adaptive variable structure control (VSC) of a class of nonlinear dynamic systems with backlash hysteresis affecting the input is considered in this paper. Utilizing the solution properties of the nonlinear differential equation that models backlash hysteresis, a robust adaptive VSC controller is developed and used to achieve global asymptotic tracking without the need to use an adaptive backlash inverse controllers. Simulation studies utilizing the proposed controller on a one degree-of-freedom system suffering from input backlash elucidate the robustness and performance aspects of this approach
Computation by oscillations: Implications of experimental data for theoretical models of grid cells

Recordings in awake, behaving animals demonstrate that cells in medial entorhinal cortex (mEC) show “grid cell” firing activity when a rat explores an open environment. Intracellular recording in slices from different positions along the dorsal to ventral axis show differences in intrinsic properties such as subthreshold membrane potential oscillations (MPO), resonant frequency, and the presence of the hyperpolarization‐activated cation current (h‐current). The differences in intrinsic properties correlate with differences in grid cell spatial scale along the dorsal–ventral axis of mEC. Two sets of computational models have been proposed to explain the grid cell firing phenomena: oscillatory interference models and attractor‐dynamic models. Both types of computational models are briefly reviewed, and cellular experimental evidence is interpreted and presented in the context of both models. The oscillatory interference model has variations that include an additive model and a multiplicative model. Experimental data on the voltage‐dependence of oscillations presented here support the additive model. The additive model also simulates data from ventral neurons showing large spacing between grid firing fields within the limits of observed MPO frequencies. The interactions of h‐current with synaptic modification suggest that the difference in intrinsic properties could also contribute to differences in grid cell properties due to attractor dynamics along the dorsal to ventral axis of mEC. Mechanisms of oscillatory interference and attractor dynamics may make complementary contributions to the properties of grid cell firing in entorhinal cortex. © 2008 Wiley‐Liss, Inc.
On Behalf of the Hermes–collaboration

Single–spin asymmetries in semi–inclusive pion production are measured by the HERMES experiment for the first time, with a transversely polarised hydrogen target. Two different sine–dependencies are extracted which can be related to the quark distributions transversity h1(x) and the Sivers function f ⊥ 1T (x).
Explaining Organizational Employee Computer Abuse Through an Extended Health Belief Model

This study is set out to examine the determinants that drive preventive/protective as well as abusive behaviors among employees in the context of information security by extending the health belief model - a model set out to explain and predict healthy behaviors in human beings. A field experiment, accompanied by an online surveys in two financial organizations in the US and India is conducted, measuring employees’ actual security behaviors. We identified factors (perceived susceptibility, perceived barriers, and self-efficacy) that have the largest effect on employee’s security behaviors. We offer several theoretical contributions and implications for practice.
Intersection Types from a Proof-theoretic Perspective

In this work we present a proof-theoretical justification for the intersection type assignment system IT by means of the logical system Intersection Synchronous Logic ISL. ISL builds classes of equivalent deductions of the implicative and conjunctive fragment of the intuitionistic logic NJ. ISL results from decomposing intuitionistic conjunction into two connectives: a synchronous conjunction, that can be used only among equivalent deductions of NJ, and an asynchronous one, that can be applied among any sets of deductions of NJ. A term decoration of ISL exists so that it matches both: the IT assignment system, when only the synchronous conjunction is used, and the simple types assignment with pairs and projections, when the asynchronous conjunction is used. Moreover, the proof of strong normalization property for ISL is a simple consequence of the same property in NJ and hence strong normalization for IT comes for free.
On stochastic proximal gradient algorithms

We study a perturbed version of the proximal gradient algorithm for which the gradient is not known in closed form and should be approximated. We address the convergence and derive a non-asymptotic bound on the convergence rate for the perturbed proximal gradient, a perturbed averaged version of the proximal gradient algorithm and a perturbed version of the fast iterative shrinkage-thresholding (FISTA) of \cite{becketteboulle09}. When the approximation is achieved by using Monte Carlo methods, we derive conditions involving the Monte Carlo batch-size and the step-size of the algorithm under which convergence is guaranteed. In particular, we show that the Monte Carlo approximations of some averaged proximal gradient algorithms and a Monte Carlo approximation of FISTA achieve the same convergence rates as their deterministic counterparts. To illustrate, we apply the algorithms to high-dimensional generalized linear mixed models using $\ell_1$-penalization.
Orbital dynamics of three‐dimensional bars – I. The backbone of three‐dimensional bars. A fiducial case

In this series of papers we investigate the orbital structure of three-dimensional (3D) models representing barred galaxies. In the present introductory paper we use a fiducial case to describe all families of periodic orbits that may play a role in the morphology of three-dimensional bars. We show that, in a 3D bar, the backbone of the orbital structure is not just the x1 family, as in two-dimensional (2D) models, but a tree of 2D and 3D families bifurcating from x1. Besides the main tree we have also found another group of families of lesser importance around the radial 3:1 resonance. The families of this group bifurcate from x1 and influence the dynamics of the system only locally. We also find that 3D orbits elongated along the bar minor axis can be formed by bifurcations of the planar x2 family. They can support 3D bar-like structures along the minor axis of the main bar. Banana-like orbits around the stable Lagrangian points build a forest of 2D and 3D families as well. The importance of the 3D x1-tree families at the outer parts of the bar depends critically on whether they are introduced in the system as bifurcations in z or in z˙.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KECELAKAAN KERJA PADA PEKERJA BENGKEL MOBIL KOTA KENDARI TAHUN 2016

Kecelakaan kerja merupakan salah satu permasalahan yang sering terjadi pada pekerja dan juga pada pengusaha.Kecelakaan kerja ini biasanya terjadi karena faktor dari pekerja itu sendiri dan lingkungan kerja yang dalam hal ini adalahdari pihak pengusaha. Tujuan penelitian ini untuk mengetahui hubungan durasi kerja, kelelahan kerja, sikap kerja,pengetahuan k3 dan penggunaan APD dengan kecelakaan kerja pada pekerja bengkel mobil Kota Kendari Tahun 2016.Metode penelitian ini adalah penelitian observasional analitik dengan pendekatan cross sectional yang bertujuan untukmendapatkan gambaran mengenai faktor yang berhubungan dengan kejadian kecelakaan kerja pada pekerja bengkel mobilkota kendari. Penelitian ini dilaksanakan pada 18 Januari – 3 Februari 2016 sampai selesai dengan lokasi penelitian padabengkel mobil Tipe A di Kota Kendari. Adapun sampel dalam penelitian ini yaitu seluruh total populasi berjumlah 49 orang.Hasil penelitian menunjukkan bahwa tidak terdapat hubungan antara durasi kerja dengan kecelakaan kerja dimana P>α, terdapat hubungan antara kelelahan kerja dengan kecelakaan kerja dimana nilai P< α dengan nilai hubungan keduavariabel bernilai sedang (phi=0,471), terdapat hubungan antara sikap kerja dengan kecelakaan kerja dimana nilai Pvalue <α dengan nilai hubungan kedua variabel bernilai kuat (phi=0,582), terdapat hubungan antara pengetahuan K3 dengankecelakaan kerja dimana nilai Pvalue < α dengan nilai hubungan kedua variabel bernilai kuat (phi=0,655) dan terdapathubungan antara penggunaan APD dengan kecelakaan kerja dimana nilai Pvalue < α dengan nilai hubungan kedua variabelbernilai sedang (phi=0,418). Sebaiknya para pekerja bengkel mobil lebih diperhatikan dalam aspek durasi kerja, sikap kerja,pengetahuan k3 dan penggunaan APD agar terhindar dari hal-hal yang tidak diinginkan.Kata kunc i: Kecelakaan Kerja, Durasi Kerja, Kelelahan Kerja, Sikap Kerja, Pengetahuan K3, Penggunaan APD, Bengkel Mobil.Value
Determinants of Entrepreneurial Attitudes in Relation to Students of Economics and Non-Economics (Determinanty postaw przedsiebiorczych studentow kierunkow ekonomicznych i nieekonomicznych)

The issue of entrepreneurship has become extremely popular in recent years. The reason behind the phenomenon ought to be seen in the growing significance of entrepreneurship in the development of modern economies, emphasis on competence development and individuals’ activity. The literature of the subject discusses academic entrepreneurship with growing frequency. The issue is associated with the changing role of the modern university. At present, universities are becoming the place where students’ attitudes and competences are shaped in the context of challenges posed by the increasingly competitive labor market and innovative economy. The subject matter of the present paper pertains to entrepreneurial competences and attitudes of students representing selected university courses. The objective of the paper is to identify entrepreneurial competences and factors determining pro entrepreneurial attitudes of respondents. The authors attempt to evaluate students’ readiness to undertake vocational activities, especially these associated with self-employment. The study allowed a comparative analysis of respondents’ competences and attitudes with regard to entrepreneurial activities to be conducted. The following research questions were posed: Do the students of the assessed university courses in economy who are considered more inclined and predestined to establish a business feel more prepared to do so and declare higher entrepreneurial competences than remaining respondents? Does the particular course of studies determine the decision pertaining to becoming self-employed?
Truth Value Judgment Task

The following are the stimuli that were used in the truth-value judgement task. Zibun is used as the example reflexive for the sentences commenting on the stories. Zibun-zisin are interchangeable with zibun in all sentences. When kare-zisin was the reflexive, all characters in the story and sentences were of males, and when kanozyo-zisin was the reflexive, all characters were females.
Approach Multiclass SVM Utilizing Genetic Algorithms

In this paper, we investigate and evaluate the performance of a simple approach mult 1 iclass for support vector machine (SVM) method. We present a new architecture, named GASVM, and based en genetic algorithms, in order to achieve high classification efficiency for multiclass problems. The proposed paradigm builds a binary tree, for solving multiclass problems, by genetic algorithms with the aim of obtaining a strategy multiclass SVM with a reasonable and practical complexity in the real problems. Our approach is more accurate in the creation of the tree. Further, in the test phase our contribution, due to its Log complexity, it is much faster than other methods in problems that have big class number. For the evaluation two corpuses are used; TIMIT corpus, where we achieved a recognition rate of 57.54% on the 20 vowels and MNIST datasets who's a recognition rate of 97.73% is achieved. These results are comparable with the state of the arts. In addition, training time and number of support vectors, which determine the duration of the tests, are also reduced compared to other methods. However, these results are unacceptably large for the real application tasks.
Functional and Biochemical Evidence for Heteromeric ATP-gated Channels Composed of P2X1 and P2X5Subunits*

The mammalian P2X receptor gene family encodes two-transmembrane domain nonselective cation channels gated by extracellular ATP. Anatomical localization data obtained by in situ hybridization and immunocytochemistry have shown that neuronal P2X subunits are expressed in specific but overlapping distribution patterns. Therefore, the native ionotropic ATP receptors diversity most likely arises from interactions between different P2X subunits that generate hetero-multimers phenotypically distinct from homomeric channels. Rat P2X1 and P2X5 mRNAs are localized within common subsets of peripheral and central sensory neurons as well as spinal motoneurons. The present study demonstrates a functional association between P2X1 and P2X5subunits giving rise to hybrid ATP-gated channels endowed with the pharmacology of P2X1 and the kinetics of P2X5. When expressed in Xenopus oocytes, hetero-oligomeric P2X1+5 ATP receptors were characterized by slowly desensitizing currents highly sensitive to the agonist α,β-methylene ATP (EC50 = 1.1 μm) and to the antagonist trinitrophenyl ATP (IC50 = 64 nm), observed with neither P2X1 nor P2X5 alone. Direct physical evidence for P2X1+5co-assembly was provided by reciprocal subunit-specific co-purifications between epitope-tagged P2X1 and P2X5 subunits transfected in HEK-293A cells.
Tools to Assist Restrained Eaters: A Query Theory and Regulatory Focus Theory Approach

Tools to Assist Restrained Eaters: A Query Theory and Regulatory Focus Theory Approach Sudy Majd For chronic dieters, modern food environments make it very difficult to always behave inline with health goals. Approximately 45 million Americans report never fully being off a diet because they fail to reach their weight loss goals. These individuals are colloquially known as chronic dieters but in the food behavior and literature, these people are known as Restrained Eaters. Restrained Eaters are known for the vacillation between food restraint and disinhibition. Past research has demonstrated that one way to keep Restrained Eaters from reach disinhibition is to prevent or weaken their involuntary physical and cognitive responses to external food cues. In a series of three lab studies, this dissertation tests two novel approaches to influencing the behavior of Restrained Eaters when faced with a hedonic food item. The focus of Study 1 is on using Query Theory to test whether there is an effect of endowment on decision and whether thoughts predict decision. We found a significant effect of endowment on the decision of Restrained and Unrestrained Eaters. Study 2 also uses Query Theory but reverse the natural order in which participants generated thoughts and whether that had an effect on decision. In Study 2, we found changing the natural order of thoughts can reverse the effect of endowment. Studies 3 and 4 reanalyze the data from Studies 1 and 2 using Regulatory Focus Theory. In this reanalysis, we found thoughts coded using regulatory focus also predicted behavior. We use the results from this reanalysis to justify Study 5, which is a test of regulatory focus inductions on decision. We found no significant effect of regulatory focus inductions on the decision of Restrained or Unrestrained Eaters. This research aims to develop interventions that will help Restrained Eaters make decisions that are not overshadowed by external cues or instant gratification, giving them a better chance to reach a sought out goal.
Prayer and Health: Conceptual Issues, Research Review, and Research Agenda

The theoretical and empirical literature on the relationship between prayer and health is critically reviewed. Although empirical research partially confirms that prayer promotes a variety of health outcomes, the empirical literature is characterized by weak methodologies that may contribute to the inconsistency of some findings. Recommendations are made for improving the quality of prayer and health research. An agenda for further empirical investigation of the relationship between prayer and health is proposed.
A Comparison of Three Opportunity-to-Respond Strategies on the Academic Engaged Time Among High School Students Who Present Challenging Behavior

A single subject alternating treatment design across three student-teacher dyads was used to investigate the comparative impact on student academic engaged time of three opportunity-to-respond (OTR) strategies: guided notes, class-wide peer tutoring, and response cards. Participants were three high school students with disabilities with noted behavioral concerns and poor academic performance within mathematics general education courses. Results indicated all OTR interventions were effective in improving percentage of academic engaged time and reducing behavioral disruptions. Using visual analysis and an additional replication phase, response cards proved to the most efficacious in improving student outcomes. Implications for the existing knowledge base on the efficacy of OTR as well as future research within high school settings are discussed.
Interfirm mobility of married women in the Indian IT sector: evidence from Delhi

Abstract Using retrospective work-family survey data and the event-history analysis technique, this paper explores the determinants of interfirm mobility i.e. the factors influencing the firm changing decisions of women in their early careers. In particular, it explores the extent to which family events, such as marriage and first childbirth, affect women’s working duration in firms and, consequently, their decision to change jobs. Based on a sample of 295 married women, drawn from Information Technology-Information Technology Enabled Services (IT-ITES) firms in New Delhi and the National Capital Region, the findings show that, amongst individual-level characteristics, children significantly decline women’s interfirm mobility rates, but marriage does not. Amongst firm-level characteristics, lower levels of job position and promotion significantly increase interfirm mobility, whilst rotating shifts, the IT-ITES sector and good working conditions significantly decline interfirm mobility rates. The study does not find that women are less mobile. It, however, takes longer for mothers to change firms due to childcare responsibilities and the extensive searching is required to find a company with standard working hours. This study concludes that women advance their careers by maximizing both status and income rewards through interfirm mobility. The data, however, cannot demonstrate the exact rewards-gain women receive upon changing employers.