Miracle-dz/UniFAR-FTUs huggingface dataset:
Reaction Time and Decision Difficulty in the Perception of Intonation

An experiment was carried out to test the Categorical Perception as well as possible Perceptual Magnet Effects in the two boundary tone categories L% and H% in German, corresponding to statement vs. question interpretation, respectively. Additionally, reaction times (RT) were logged during all subtests to see if they support the results. Analyses revealed that RTs always increased with rising difficulty of the perceptual task, and decreased when the decision process was easy. Task-specific results showed that RT also correlated with the number of possible answers during a perceptual decision, i.e. more answer alternatives resulted in longer RT. Furthermore, female subjects generally reacted faster during all perceptual tasks, although this did not necessarily correlate with the accuracy of the results. Nevertheless, the results confirmed the usefulness of RT to support the analyses and the interpretation of perceptual data. Index Terms: prosody perception, intonation, categorical perception, perceptual magnet effect, reaction time
Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy.

BACKGROUND Few studies have directly compared the renoprotective effects of angiotensin II-receptor blockers and angiotensin-converting-enzyme (ACE) inhibitors in persons with type 2 diabetes. METHODS In this prospective, multicenter, double-blind, five-year study, we randomly assigned 250 subjects with type 2 diabetes and early nephropathy to receive either the angiotensin II-receptor blocker telmisartan (80 mg daily, in 120 subjects) or the ACE inhibitor enalapril (20 mg daily, in 130 subjects). The primary end point was the change in the glomerular filtration rate (determined by measuring the plasma clearance of iohexol) between the baseline value and the last available value during the five-year treatment period. Secondary end points included the annual changes in the glomerular filtration rate, serum creatinine level, urinary albumin excretion, and blood pressure; the rates of end-stage renal disease and cardiovascular events; and the rate of death from all causes. RESULTS After five years, the change in the glomerular filtration rate was -17.5 ml per minute per 1.73 m2 (where the minus sign denotes a decrement) in the telmisartan-treated subjects, as compared with -15.0 ml per minute per 1.73 m2 in the enalapril-treated subjects; the treatment difference was thus -2.6 ml per minute per 1.73 m2 (95 percent confidence interval, -7.1 to 2.0 ml per minute per 1.73 m2)[corrected] The lower boundary of the confidence interval, in favor of enalapril, was greater than the predefined margin of -10.0 ml per minute per 1.73 m2, indicating that telmisartan was not inferior to enalapril. The effects of the two agents on the secondary end points were not significantly different after five years. CONCLUSIONS Telmisartan is not inferior to enalapril in providing long-term renoprotection in persons with type 2 diabetes. These findings do not necessarily apply to persons with more advanced nephropathy, but they support the clinical equivalence of angiotensin II-receptor blockers and ACE inhibitors in persons with conditions that place them at high risk for cardiovascular events.
An Empirical Look at the Earnings of Japanese Men The Significance of College Quality , Occupations and Firm Size

International comparisons have identified several unique features of the Japanese labor market and its impact on earnings, namely tenure and firm-size effects, and the similarity in the structure of earnings between blueand white-collar workers. One feature which has received relatively less attention is that the rate of return (ROR) to college education in Japan is lower in comparison to her Western counterparts. However, in a country where examination hell has become a household word and students and parents alike are obsessed with college quality (or prestige), there is sufficient reason to believe that the dimension of college quality plays a vital role in determining earnings. Individuals have the incentives to get into the better colleges because they sufficiently believe that their efforts (or investments) will be realized through higher rewards. Using a 1995 cross-sectional data of Japanese workers and the mean score on the college entrance examinations attended by each individual as a measure of college quality, I follow Griliches and Mason (1972) and examine in detail the relationship between individual ability, college quality and earnings in the Japanese labor market. While considerable attention is paid to this supply-side relationship, I also investigate the impact of demand-side factors on earnings. My findings suggest that: (i) college quality does significantly improve earnings, (ii) tenure effects are significant and positive only among high-school graduates (and not college graduates), (iii) firm-size differences are manifested as an interaction effect with experience, and (iv) the earnings profiles for blueand white-collar workers are parallel. My estimations reveal that the mean ROR is . 086, but more importantly, that the ROR with respect to college quality ranges from a low of . 031 to a high of . 164. The huge variation in the ROR therefore confirms in part that the obsessive pursuit of college quality is in fact a rational pursuit, and suggests that the mean ROR used in international comparisons undermines the significance of college quality in Japan. Researchers and policymakers in the international community should therefore be reminded that college quality plays a crucial role in shaping both incentives and earnings in the Japanese labor market.
PlGF and VEGF-A Regulate Growth of High-Risk MYCN-Single Copy Neuroblastoma Xenografts via Different Mechanisms

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood and is a rapidly growing, highly-vascularized cancer. NBs frequently express angiogenic factors and high tumor angiogenesis has been associated with poor outcomes. Placental growth factor (PlGF) is an angiogenic protein belonging to the vascular endothelial growth factor (VEGF) family and is up-regulated mainly in pathologic conditions. Recently, PlGF was identified as a member of a gene expression signature characterizing highly malignant NB stem cells drawing attention as a potential therapeutic target in NB. In the present study, we sought to investigate the expression of PlGF in NB patients and the effect of PlGF inhibition on high-risk MYCN-non-amplified SK-N-AS NB xenografts. Human SK-N-AS cells, which are poorly differentiated and express PlGF and VEGF-A, were implanted subcutaneously in athymic nude mice. Treatment was done by intratumoral injection of replication-incompetent adenoviruses (Ad) expressing PlGF- or VEGF-specific short hairpin (sh)RNA, or soluble (s)VEGF receptor 2 (VEGFR2). The effect on tumor growth and angiogenesis was analyzed. High PlGF expression levels were observed in human advanced-stage NBs. Down-regulating PlGF significantly reduced NB growth in established NB xenografts by reducing cancer cell proliferation but did not suppress angiogenesis. In contrast, blocking VEGF by administration of Ad(sh)VEGF and Ad(s)VEGFR2 reduced tumor growth associated with decreased tumor vasculature. These findings suggest that PlGF and VEGF-A modulate MYCN-non-amplified NB tumors by different mechanisms and support a role for PlGF in NB biology.
OLAP and statistical databases: similarities and differences (abstract)

During the 1980's there was a lot of activity in the area of Statistical Databases, focusing mostly on socio-economic type applications, such as census data, national production and consumption patterns, etc. In the 1990's the area of On-Line-Analytic Processing (OLAP) was introduced for the analysis of transaction based business data, such as retail stores transactions. Both areas deal with the representation and support of data in a multi-dimensional space. Much of the OLAP literature does not refer to the Statistical Database literature, perhaps because the connection between analyzing business data and socioeconomic data is not obvious. Furthermore, there are papers published in one area or the other whose results can be applied in both application areas.
ICFSIFT: Improving Collection-Specific CBIR with ICF-Based Local Features

We present a new adaptive local feature, ICFSIFT, which utilises SIFT keypoints and Independent Component Analysis. The ICFSIFT feature combines the keypoint detection, and scale and orientation invariance, of SIFT with the collection-specific adaptive properties of Independent Component Filter (ICF) features. We evaluate the performance of this feature for image retrieval on two standard texture collections, comparing with SIFT features and previously published global ICF features. On both collections the ICFSIFT features perform best. We also show that combining these ICFSIFT features with the ICF-based global features further improves CBIR performance.
The effectiveness of interpersonal skills training on the social skill acquisition of moderately and mildly retarded adults.

Sixteen moderately and mildly retarded adults were selected from a group residential facility and randomly assigned to experimental and control groups. The experimental group received a 12-session interpersonal skills training program consisting of instruction in the following areas: (1) Introduction and Small Talk, (2) Asking for Help, (3) Differing with Others, and (4) Handling Criticism. The social skills instructional package included verbal instruction, modeling, role playing, feedback, contingent incentives, and homework. As a result of this training program, moderately and mildly retarded adults acquired new social skills as evidenced by performance on a situation role play assessment. These gains generalized to untrained role play situations but did not result in significant group differences when assessed in a more natural setting (i.e., local grocery store).
Declarative and Computational Properties of Logic Programs with Aggregates

We investigate the properties of logic programs with aggregates. We mainly focus on programs with monotone and antimonotone aggregates (LPm,aA programs). We define a new notion of unfounded set for (LPm,aA programs, and prove that it is a sound generalization of the standard notion of unfounded set for aggregate-free programs. We show that the answer sets of an LPm,aA program are precisely its unfounded-free models. We define a well-founded operator WP for LPm,aA programs; we prove that its total fixpoints are precisely the answer sets of P, and its least fixpoint WPw(0) is contained in the intersection of all answer sets (if P admits an answer set). WPW(0) is efficiently computable, and for aggregate-free programs it coincides with the well-founded model. We carry out an in-depth complexity analysis in the general framework, including also nonmonotone aggregates. We prove that monotone and anti-monotone aggregates do not increase the complexity of cautious reasoning, which remains in co-NP. Nonmonotone aggregates, instead, do increase the complexity by one level in the polynomial hierarchy. Our results allow also to generalize and speed-up ASP systems with aggregates.
Optimal power allocation for relayed transmissions over Rayleigh-fading channels

Relayed transmission is a way to attain broader coverage by splitting the communication link from the source to the destination into several shorter links/hops. One of the main advantages of this communication technique is that it distributes the use of power throughout the hops. This implies longer battery life and lower interference introduced to the rest of the network. In this context, this paper investigates the optimal allocation of power over these links/hops for a given power budget. All hops are assumed to be subject to independent Rayleigh fading. Outage probability which is the probability that the link quality from source to destination falls below a certain threshold is used as the optimization criterion. Numerical results show that optimizing the allocation of power enhances the system performance, especially if the links are highly unbalanced in terms of their average fading power or if the number of hops is large. Interestingly, they also show that nonregenerative systems with optimum power allocation can outperform regenerative systems with no power optimization.
Parameters Selection for Bivariate Multiscale Entropy Analysis of Postural Fluctuations in Fallers and Non-Fallers Older Adults

Entropy measures are often used to quantify the regularity of postural sway time series. Recent methodological developments provided both multivariate and multiscale approaches allowing the extraction of complexity features from physiological signals; see “Dynamical complexity of human responses: A multivariate data-adaptive framework,” in Bulletin of Polish Academy of Science and Technology, vol. 60, p. 433, 2012. The resulting entropy measures are good candidates for the analysis of bivariate postural sway signals exhibiting nonstationarity and multiscale properties. These methods are dependant on several input parameters such as embedding parameters. Using two data sets collected from institutionalized frail older adults, we numerically investigate the behavior of a recent multivariate and multiscale entropy estimator; see “Multivariate multiscale entropy: A tool for complexity analysis of multichannel data,” Physics Review E, vol. 84, p. 061918, 2011. We propose criteria for the selection of the input parameters. Using these optimal parameters, we statistically compare the multivariate and multiscale entropy values of postural sway data of non-faller subjects to those of fallers. These two groups are discriminated by the resulting measures over multiple time scales. We also demonstrate that the typical parameter settings proposed in the literature lead to entropy measures that do not distinguish the two groups. This last result confirms the importance of the selection of appropriate input parameters.
Increased Expression of Angiogenic and Inflammatory Proteins in the Vitreous of Patients with Ischemic Central Retinal Vein Occlusion

Background Central retinal vein occlusion (CRVO) is a common disease characterized by a disrupted retinal blood supply and a high risk of subsequent vision loss due to retinal edema and neovascular disease. This study was designed to assess the concentrations of selected signaling proteins in the vitreous and blood of patients with ischemic CRVO. Methods Vitreous and blood samples were collected from patients undergoing surgery for ischemic CRVO (radial optic neurotomy (RON), n = 13), epiretinal gliosis or macular hole (control group, n = 13). Concentrations of 40 different proteins were determined by an ELISA-type antibody microarray. Results Expression of proteins enriched in the vitreous (CCL2, IGFBP2, MMP10, HGF, TNFRSF11B (OPG)) was localized by immunohistochemistry in eyes of patients with severe ischemic CRVO followed by secondary glaucoma. Vitreal expression levels were higher in CRVO patients than in the control group (CRVO / control; p < 0.05) for ADIPOQ (13.6), ANGPT2 (20.5), CCL2 (MCP1) (3.2), HGF (4.7), IFNG (13.9), IGFBP1 (14.7), IGFBP2 (1.8), IGFBP3 (4.1), IGFBP4 (1.7), IL6 (10.8), LEP (3.4), MMP3 (4.3), MMP9 (3.6), MMP10 (5.4), PPBP (CXCL7 or NAP2) (11.8), TIMP4 (3.8), and VEGFA (85.3). In CRVO patients, vitreal levels of CCL2 (4.2), HGF (23.3), IGFBP2 (1.23), MMP10 (2.47), TNFRSF11B (2.96), and VEGFA (29.2) were higher than the blood levels (vitreous / blood, p < 0.05). Expression of CCL2, IGFBP2, MMP10, HGF, and TNFRSF11B was preferentially localized to the retina and the retinal pigment epithelium (RPE). Conclusion Proteins related to hypoxia, angiogenesis, and inflammation were significantly elevated in the vitreous of CRVO patients. Moreover, some markers known to indicate atherosclerosis may be related to a basic vascular disease underlying RVO. This would imply that local therapeutic targeting might not be sufficient for a long term therapy in a systemic disease but hypothetically reduce local changes as an initial therapeutic approach.
Prospective Analysis of Placenta Growth Factor (PlGF) Concentrations in the Plasma of Women with Normal Pregnancy and Pregnancies Complicated by Preeclampsia

Objective: The aim of this study was to analyze if levels of plasma PlGF in the second half of pregnancy have predictive value for the identification of women destined to develop preeclampsia or another complication of pregnancy. Material and Methods: A bank of 1.543 randomly collected plasma samples (22–29 weeks of gestation) was established and PlGF concentrations were quantitated in a prospective longitudinal study in all pregnant women who developed a complication of pregnancy in late gestation (177 of 1.543) and the same number of gestational age matched pregnancies with normal outcome. Results: Plasma PlGF levels in pregnant women rise steadily throughout pregnancy from the level of nonpregnant women (< 50 pg/mL) to levels exceeding 500 pg/mL after 30 weeks of gestation. Just 7.3% of pregnant women with normal outcome of pregnancy had PlGF levels of less than 200 pg/mL beyond 22 weeks of gestation (3.7% beyond 25 weeks of gestation). The rise in plasma PlGF in the second half of pregnancy was significantly attenuated in pregnancies that were complicated by preeclampsia in late gestation. Of all women who developed preeclampsia, 27.3% (12 of 44) had plasma PlGF levels below 200 pg/mL. The attenuation of the rise in plasma PlGF was not evident in other complications of pregnancy (transient hypertension, fetal retardation, pregnancy diabetes, premature contractions, proteinuria without hypertension, infections during pregnancy). Conclusion: The rise in plasma PlGF levels observed in normal pregnancies is significantly attenuated in pregnancies complicated by preeclampsia. Yet, due to the low sensitivity and specificity, plasma PlGF levels in the second half of pregnancy have no predictive value for the identification of individual women destined to develop preeclampsia.
Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor.

Cell growth and viability are dependent on the function of the multicatalytic proteinase complex (proteasome), a multisubunit particle that affects progression through the mitotic cycle by degradation of cyclins. Exposure of rodent fibroblasts and human lymphoblasts in culture to benzyloxycarbonyl-leucyl-leucyl-phenylalaninal (Z-LLF-CHO), a cell-permeable peptidyl aldehyde inhibitor of the chymotrypsin-like activity of the proteasome, resulted in the induction of apoptosis in a rapid, dose-dependent fashion. Fibroblasts transformed with ras and myc, lymphoblasts transformed by c-myc alone, and a Burkitt's lymphoma (BL) cell line that overexpresses c-Myc were up to 40-fold more susceptible to apoptosis than were either primary rodent fibroblasts or immortalized nontransformed human lymphoblasts, respectively. To determine whether such preferential apoptosis could impact upon tumor growth in vivo, toxicological studies were performed in mice with severe combined immunodeficiency and showed that mice tolerated single interscapular doses of Z-LLF-CHO without unacceptable toxicity. Severe combined immunodeficient mice bearing s.c. BL tumors in the flank were treated interscapularly with Z-LLF-CHO or a comparable dose of the peptidyl alcohol (Z-LLF-OH), which does not induce proteasome inhibition or apoptosis. Single doses of Z-LLF-CHO induced statistically significant (P < 0.0001) early tumor regression and a significant (P < 0.0001) delay in tumor progression. Analysis of tumor specimens revealed increased apoptosis in BL tumors from mice treated with Z-LLF-CHO. These results, showing a 42% tumor growth delay, indicate that proteasome inhibitors have the potential of curbing the growth of a c-myc-related tumor.
Types and Subtypes of the Posterior Part of the Cerebral arterial Circle in Human Adult Cadavers

The main cerebral distribution center of 15-20% blood flow from the cardiac output is the cerebral arterial circle or circle of Willis, a nonagon of collateral vessels on the human brain base. At about 4 mm stage of the embryo, the primitive internal carotid arteries, which develop as cranial extensions of the paired dorsal aorta, are formed. Paired longitudinal neural arteries appear along the hindbrain and coalesce to form the basilar trunk at the 7to 12-mm stage. The caudal division of the primitive internal carotid artery anastomoses with ipsilateral neural artery and becomes the posterior communicating artery. At the 40-mm stage the posterior cerebral arteries are as extensions of the posterior communicating arteries. The vertebrobasilar system develops and thus participates in the supply of the posterior cerebral artery through the segment between the basilar artery and the post-communicating part of the posterior cerebral artery. In that phase, the component vessels of the circle of Willis all have the same caliber (Silver & Wilkins, 1991). The posterior cerebral artery originates from the basilar bifurcation within the interpeduncular cistern. From its origin the artery curves superior to the corresponding oculomotor nerve in relation to the antero-medial portion of the cerebral peduncle and joins ipsilateral posterior communicating artery (Yasargil, 1984). The posterior communicating artery takes origin from the infero-lateral wall of the cerebral part of the internal carotid artery. It is encased in a sleeve of arachnoid along the course from the carotid cistern to the piercing of the interpeduncular cistern and junction with posterior cerebral artery (Yasargil, 1984). Topographically, the circle of Willis is divided on anterior and posterior parts. The anterior part composes five vascular components – bilateral cerebral parts of internal carotid arteries (communicating and choroid subparts) and the pre-communicating part of anterior cerebral arteries interconnected by the anterior communicating artery; the posterior part composes
Sentinel lymph node biopsy after neoadjuvant chemotherapy for advanced breast cancer: results of Ganglion Sentinelle et Chimiotherapie Neoadjuvante, a French prospective multicentric study.

PURPOSE To determine the detection rate, the false-negative rate, and the accuracy of sentinel lymph node (SLN) detection after neoadjuvant chemotherapy (NAC) for advanced breast cancer. PATIENTS AND METHODS A prospective multicentric study was initiated to evaluate the results of SLN biopsy with the combined method after NAC for advanced large operable breast cancer. RESULTS From September 2003 to March 2007, 195 patients enrolled from 12 institutions were found suitable for evaluation. The detection rate was 90% (176 of 195 patients), and the false-negative rate was 11.5% (six of 52 patients). Patients without axillary palpable nodes (N0) before NAC had a better detection rate compared with patients with axillary suspicious nodes (N1, 94.6% v 81.5%; P = .008). The false-negative rate was not correlated with clinical nodal status before NAC (9.4% v 15%; P = .66). CONCLUSION This study confirms the feasibility of SLN biopsy after NAC in the case of large operable breast cancer. The detection rate, false-negative rate, and accuracy do not differ from those obtained in the case of early breast cancer without NAC, thus demonstrating the feasibility of SLN biopsy after NAC.