Miracle-dz/UniFAR-FTUs huggingface dataset:
Matrix approximation and projective clustering via volume sampling

Frieze et al. [17] proved that a small sample of rows of a given matrix <i>A</i> contains a low-rank approximation <i>D</i> that minimizes ||<i>A - D</i>||<i>F</i> to within small additive error, and the sampling can be done efficiently using just two passes over the matrix [12]. In this paper, we generalize this result in two ways. First, we prove that the additive error drops exponentially by iterating the sampling in an adaptive manner. Using this result, we give a pass-efficient algorithm for computing low-rank approximation with reduced additive error. Our second result is that using a natural distribution on subsets of rows (called <i>volume</i> sampling), there exists a subset of <i>k</i> rows whose span contains a factor (<i>k</i> + 1) relative approximation and a subset of <i>k</i> + <i>k</i>(<i>k</i> + 1)/ε rows whose span contains a 1+ε relative approximation. The existence of such a small certificate for multiplicative low-rank approximation leads to a PTAS for the following projective clustering problem: Given a set of points <i>P</i> in R<sup><i>d</i></sup>, and integers <i>k, j</i>, find a set of <i>j</i> subspaces <i>F</i><inf>1</inf>, . , <i>F</i><inf><i>j</i></inf>, each of dimension at most <i>k</i>, that minimize Σ<inf><i>p</i>∈P</inf>min<inf><i>i</i></inf> <i>d(p, F</i><inf><i>i</i></inf>)<sup>2</sup>.
Low‐rank approximation of tensors via sparse optimization

The goal of this paper is to find a low‐rank approximation for a given nth tensor. Specifically, we give a computable strategy on calculating the rank of a given tensor, based on approximating the solution to an NP‐hard problem. In this paper, we formulate a sparse optimization problem via an l1‐regularization to find a low‐rank approximation of tensors. To solve this sparse optimization problem, we propose a rescaling algorithm of the proximal alternating minimization and study the theoretical convergence of this algorithm. Furthermore, we discuss the probabilistic consistency of the sparsity result and suggest a way to choose the regularization parameter for practical computation. In the simulation experiments, the performance of our algorithm supports that our method provides an efficient estimate on the number of rank‐one tensor components in a given tensor. Moreover, this algorithm is also applied to surveillance videos for low‐rank approximation.
Exercise-induced dehydration alters pulmonary function but does not modify airway responsiveness to dry air in athletes with mild asthma

This study is the first to investigate the effect of whole body dehydration on airway responsiveness. Our data suggest that the airway response to dry air hyperpnea in athletes with mild asthma and/or exercise-induced bronchoconstriction is not exacerbated in a state of mild dehydration. On the basis of recorded alterations in lung volumes, however, exercise-induced dehydration appears to compromise small airway function.
Mandibular segmental defect regenerated with macroporous biphasic calcium phosphate, collagen membrane, and bone marrow graft in dogs.

OBJECTIVE To reconstruct segmental mandibulectomy using calcium phosphate ceramics and collagen membrane with a delayed bone marrow grafting in experimental animals. DESIGN Defects of segmental mandibulectomy were filled with calcium phosphate granules and wrapped with a collagen membrane in 4 dogs and left empty as a control in 2 dogs. Two months later, a bone marrow graft was injected into the center of the implants. Animals were humanely killed after a 16-week delay. SUBJECTS Six adult beagles were included in this study. INTERVENTION Segmental mandibulectomy. MAIN OUTCOME MEASURE Bone ingrowth and material resorption in the reconstructed segment. RESULTS Successful osseous colonization bridged the whole length of the defects. The good new bone formation at the center and the periosteum-like formation at the periphery suggest the osteoinductive role of the bone marrow graft and the healing scaffold role of the membrane. CONCLUSIONS This model succeeded in regenerating a large segmental defect in the mandible. An investigation with a postimplantation radiation delivery schedule is required with the use of this model, which should be considered as a preclinical study for a bone tissue engineering approach in patients with cancer-related bone defects.
Optimal dose of dabigatran for the prevention of thromboembolism with minimal bleeding risk in Korean patients with atrial fibrillation.

Aims We aim to determine the optimal dose of dabigatran in Korean patients with atrial fibrillation (AF). Methods and results We analysed 1834 patients with non-valvular AF, classified into a warfarin group (n = 990), dabigatran 150 mg group (D150, n = 294), and 110 mg group (D110, n = 550). The D110 group was further classified into patients concordant (co-D110, n = 367) and patients discordant (di-D110, n = 183) with guidelines to dose reduction. Propensity-matched 1-year clinical outcomes were then compared. Efficacy outcomes were defined as thromboembolism composed of new-onset stroke or systemic embolism. Safety outcomes were major bleeding. Both D150 and D110 had comparable efficacies as warfarin. However, only D110 significantly lowered the risk of major bleeding [hazard ratio (HR) 0.19, 95% confidence interval (CI) 0.07-0.55, P = 0.002]. In a subgroup analysis according to guideline-concordant indications for dose reduction, both co-D110 and di-D110 displayed a comparable efficacy as warfarin. Both co-D110 (HR 0.22, 95% CI 0.06-0.76, P = 0.017) and di-D110 (HR 0.11, 95% CI 0.02-0.81, P = 0.030) significantly lowered incidences of major bleeding. There were no differences in the efficacy and safety between di-D110 and D150, and net clinical outcomes were similar. Conclusion Although D150 and D110 had a comparable efficacy, only D110 lowered the risk of major bleeding in Korean AF patients compared with warfarin. Even the guideline-discordant use of dabigatran 110 mg demonstrated a similar efficacy and safety compared with D150. However, further prospective randomized trials are needed in order to comprehensively evaluate whether D150 or D110 is the optimal dosage in Asian patients with AF.
Dynamical Mechanism of Hyperpolarization-Activated Non-specific Cation Current Induced Resonance and Spike-Timing Precision in a Neuronal Model

Hyperpolarization-activated cyclic nucleotide-gated cation current (Ih) plays important roles in the achievement of many physiological/pathological functions in the nervous system by modulating the electrophysiological activities, such as the rebound (spike) to hyperpolarization stimulations, subthreshold membrane resonance to sinusoidal currents, and spike-timing precision to stochastic factors. In the present paper, with increasing gh (conductance of Ih), the rebound (spike) and subthreshold resonance appear and become stronger, and the variability of the interspike intervals (ISIs) becomes lower, i.e., the enhancement of spike-timing precision, which are simulated in a conductance-based theoretical model and well explained by the nonlinear concept of bifurcation. With increasing gh, the stable node to stable focus, to coexistence behavior, and to firing via the codimension-1 bifurcations (Hopf bifurcation, saddle-node bifurcation, saddle-node bifurcations on an invariant circle, and saddle homoclinic orbit) and codimension-2 bifurcations such as Bogdanov-Takens (BT) point related to the transition between saddle-node and Hopf bifurcations, are acquired with 1- and 2-parameter bifurcation analysis. The decrease of variability of ISIs with increasing gh is induced by the fast decrease of the standard deviation of ISIs, which is related to the increase of the capacity of resisting noisy disturbance due to the firing becomes far away from the bifurcation point. The enhancement of the rebound (spike) with increasing gh builds up a relationship to the decrease of the capacity of resisting disturbance like the hyperpolarization stimulus as the resting state approaches the bifurcation point. The “typical”-resonance and non-resonance appear in the parameter region of the stable focus and node far away from the bifurcation points, respectively. The complex or “strange” dynamics, such as the “weak”-resonance for the stable node near the transition point between the stable node and focus and the non-resonance for the stable focus close to the codimension-1 and −2 bifurcation points, are discussed.
A cross-sectional survey of nutrition labelling use and its associated factors on parents of school students in Shanghai, China

Abstract Objective To understand parents’ knowledge and use of nutrition labelling and to explore its associated factors. Design Cross-sectional survey. Setting Two schools providing a nine-year educational programme in Putuo District, Shanghai, China, were selected for the study. Information was included on demographic data and knowledge of the Chinese Food Pagoda. Subjects Students and their parents (n 1770) participated in a questionnaire survey. Results Of questionnaires, 1766 were completed (response rate 99·8 %). Utilization rate of nutrition labelling was 19·3 %. Among 624 parents knowing nutrition labelling, 22·1 % understood all the information included, 70·7 % understood it partially and 7·2 % could not understand it at all. Use of nutrition labelling by parents was related to the following factors (OR; 95 % CI): high educational level of parent (1·465; 1·165, 1·841), parent’s knowledge of the Chinese Food Pagoda (1·333; 1·053, 1·688), parent’s consumption of top three snacks which are unhealthy (1·065; 1·023, 1·109), parent’s assumption that nutrition labelling would affect their choice of food (1·522; 1·131, 2·048), student’s willingness to learn about labels (1·449; 1·093, 1·920) and student’s knowledge and use of labels (2·214; 1·951, 2·513). Conclusions Parents’ knowledge and use of nutrition labelling are still at a lower level, and some information included in the nutrition labels is not understood by parents. The forms of the existing nutrition labelling need to be continuously improved to facilitate their understanding and usefulness. It is necessary to establish nutrition projects focusing on education and use of nutrition labels which help parents and their children make the right choices in selecting foods.
Plasma Phosphatidylcholine Alterations in Cystic Fibrosis Patients: Impaired Metabolism and Correlation with Lung Function and Inflammation

Background: Liver impairment, ranging from steatosis to cirrhosis, is frequent in cystic fibrosis (CF) patients and is becoming increasingly significant due to their improved life expectancy. One aspect of hepatic alterations is caused by increased fecal loss of the essential nutrient choline, following enterohepatic bile phosphatidylcholine (PC) cycle impairment. Hepatic PC synthesis, both de novo and via phosphatidylethanolamine-N-methyl-transferase (PEMT), is essential for very low-density lipoprotein (VLDL) secretion. VLDL-PC in particular contributes to the organism's supply with polyunsaturated fatty acids (LC-PUFA), namely arachidonic (C20:4) and docosahexaenoic acid (C22:6). Consequently, choline deprivation and altered hepatic PC metabolism may affect plasma PC homeostasis and extrahepatic organ function. Objectives: To investigate relationships between altered plasma choline and PC homeostasis and markers of lung function and inflammation in CF. To assess alterations in hepatic choline and PC metabolism of CF patients. Design: Quantification of plasma/serum choline and PC species in adult CF patients compared to controls. Correlation of PC with forced expiratory vital capacity (FEV1) and interleukin 6 (IL-6) concentrations. Analysis of choline and PC metabolism in CF compared to controls, using deuterated choline ([D9-methyl]-choline) labeling in vivo. Results: Mean choline and PC concentrations in CF patients were lower than in controls. Choline and PC concentrations as well as fractions of C22:6-PC and C20:4-PC correlated directly with FEV1, but inversely with IL-6. Plasma concentrations of deuterated PC were decreased for both pathways, whereas only in PC synthesized via PEMT precursor enrichment was decreased. Conclusion: In CF patients, hepatic and plasma homeostasis of choline and PC correlate with lung function and inflammation. Impaired hepatic PC metabolism, exemplarily shown in three CF patients, provides an explanation for such correlations. Larger studies are required to understand the link between hepatic PC metabolism and overall clinical performance of CF patients, and the perspective of choline substitution of these patients.
Repeating Critical Hematology and Coagulation Values Wastes Resources, Lengthens Turnaround Time, and Delays Clinical Action

Objectives To determine the need and impact of repeating critical values in hematology and coagulation. Methods We prospectively evaluated the need for repeating critical values. The cost of this practice was estimated using a workflow analysis. Retrospective chart review before and after removal of this process was performed to assess the clinical impact of removing this practice. Results Over 95% of the repeated values remained critical and all but one of the repeats were within the expected analytical precision of the assays. The practice of repeating critical values delayed turnaround time for these results and wasted resources, most notably manpower. The delay associated with repeating hematology critical values resulted in delayed administration of blood product (RBC units). Conclusions Repeating critical hematology and coagulation results was found to be an unnecessary process that wasted laboratory resources and lengthened turnaround time, delaying clinical intervention.
Comparison of Transjugular Liver Biopsy and Percutaneous Liver Biopsy With Tract Embolization in Pediatric Patients

Purpose: The aim of the study was to compare safety and efficacy of transjugular liver biopsy (TJLB) and percutaneous liver biopsy (PLB) with tract embolization in pediatric patients with liver disease. Materials and Methods: TJLB and PLB between December 2009 and October 2015 were retrospectively reviewed. Primary endpoints were adequate sampling and complication rate. Patient age, weight, coagulation factors, ascites, blood transfusions, adequacy of biopsy sample, number of biopsy samples, and complications were compared. Results: There were 39 TJLB (average age 10.6 years) and 120 PLB (average age 7.1 years) (P value <0.05). Average weight was 40.2 kg for TJLB and 26.8 kg for PLB (P value <0.05). Average platelets were 155 for TJLB and 252 for PLB (P value <0.05). Average international normalized ratio was 1.7 for TJLB and 1.3 for PLB (P value <0.05). Mean postbiopsy hematocrit decrease was 0.8 and 0.9, for TJLB and PLB, respectively. Mean postbiopsy hemoglobin decrease was 0.3 in both groups. Number of core biopsy samples was 4.5 and 4.3, for TJLB and PLB, respectively. There was 1 biopsy yielding insufficient sample in each group. TJLB had 1 (2.6%) complication of supraventricular tachycardia. PLB had 4 (3.3%) complications, with 1 hemoperitoneum, 1 hypotension, 1 patient with decreased hemoglobin, and 1 patient with bilious drainage from the biopsy site. Conclusions: TJLB and PLB with gelatin sponge pledget tract embolization are both safe and effective for the diagnosis of hepatic disease in pediatric patients. To avoid radiation, PLB may be considered as first-line approach in the pediatric population, even in the setting of coagulopathy.
Surgical treatment versus conventional chest tube drainage in primary spontaneous pneumothorax: a randomized controlled trial†

OBJECTIVES Primary spontaneous pneumothorax frequently recurs after chest tube management. Evidence is lacking whether patients may benefit from surgery following their first episode. METHODS We performed a multicentre, randomized trial and enrolled young, otherwise healthy patients admitted with their first episode of primary spontaneous pneumothorax and treated using conventional chest tube drainage. Patients underwent high-resolution computed tomography on fully expanded lungs, and using web-based randomization, we assigned patients to continued conservative chest tube treatment or chest tube treatment followed by video-assisted thoracoscopic surgery (VATS) with the resection of bullae/blebs and mechanical pleurodesis. Patients were stratified into 2 groups based on the presence of bullae ≥1 cm on high-resolution computed tomography. The primary end point was readmission with ipsilateral recurrence. Secondary end points were complications and length of hospitalization. RESULTS Between 1 August 2009 and 4 November 2016, we screened 457 patients, of whom 373 were eligible for inclusion and 181 were enrolled: male/female ratio = 5.0. We identified 88 patients with blebs <1 cm: 50 were randomly assigned to chest tube treatment and 38 to VATS. Ninety-three patients had bullae ≥1 cm: 43 were randomly assigned to chest tube treatment and 50 to VATS. Forty-three (23.8%) patients experienced recurrence during the follow-up period. Overall, recurrence was significantly lower following VATS when compared with conventional chest tube treatment (P = 0.0012). When stratified by bullae size, VATS proved significantly better for bullae ≥1 cm (P = 0.014). We observed a size-response relationship with increased risk of recurrence for larger bullae (P = 0.013). CONCLUSIONS Surgery was an effective treatment to prevent recurrence in patients with their first presentation of primary spontaneous pneumothorax and should be the standard of care when high-resolution computed tomography demonstrates bullae ≥2 cm. Clinical trial registration ClinicalTrial.gov: NCT 02866305.
Impact of Structured Rounding Tools on Time Allocation During Multidisciplinary Rounds: An Observational Study

Background Recent research has shown evidence of disproportionate time allocation for patient communication during multidisciplinary rounds (MDRs). Studies have shown that patients discussed later during rounds receive lesser time. Objective The aim of our study was to investigate whether disproportionate time allocation effects persist with the use of structured rounding tools. Methods Using audio recordings of rounds (N=82 patients), we compared time allocation and communication breakdowns between a problem-based Subjective, Objective, Assessment, and Plan (SOAP) and a system-based Handoff Intervention Tool (HAND-IT) rounding tools. Results We found no significant linear dependence of the order of patient presentation on the time spent or on communication breakdowns for both structured tools. However, for the problem-based tool, there was a significant linear relationship between the time spent on discussing a patient and the number of communication breakdowns (P<.05)––with an average of 1.04 additional breakdowns with every 120 seconds in discussion. Conclusions The use of structured rounding tools potentially mitigates disproportionate time allocation and communication breakdowns during rounds, with the more structured HAND-IT, almost completely eliminating such effects. These results have potential implications for planning, prioritization, and training for time management during MDRs.
On the Weight of Halfspaces over Hamming Balls

For $S \subseteq \{0,1\}^n$, a Boolean function $f: S \to \{-1,1\}$ is a halfspace over $S$ if there exist $w \in \mathbb{R}^n$ and $\theta \in \mathbb{R}$ such that $f(x)=\mathrm{sign}(w \cdot x - \theta)$ for all $x \in S$. We give bounds on the size of integer weights $w_1,\dots,w_n \in \mathbb{Z}$ that are required to represent halfspaces over Hamming balls $S = \{x \in \{0,1\}^n : x_1 + \cdots + x_n \leq k\}. $ Such weight bounds for halfspaces over Hamming balls have immediate consequences for the performance of learning algorithms in the common scenario of learning from very high-dimensional categorical examples which are such that only a small number of features are active in each example. We give upper and lower bounds on weight both for exact representation (when $\mathrm{sign}(w \cdot x {-\theta})$ must equal $f(x)$ for every $x \in S$) and for $\varepsilon$-approximate representation (when $\mathrm{sign}(w \cdot x {- \theta})$ may disagree with $f(x)$ for up to an $\varepsilon$ fraction of poin.
Association between serum phospholipid fatty acid levels and adiposity in Mexican women[S]

Fatty acids (FAs) have been postulated to impact adiposity, but few epidemiological studies addressing this hypothesis have been conducted. This study investigated the association between serum phospholipid FAs (S-PLFAs) and indicators of obesity. BMI and waist-to-hip ratio (WHR) were collected from 372 healthy Mexican women included as controls in a case-control study. S-PLFA percentages were determined through gas chromatography. Desaturation indices, SCD-16, SCD-18, FA desaturase (FADS)1, and FADS2, biomarkers of endogenous metabolism, were proxied respectively as 16:1n-7/16:0, 18:1n-9/18:0, 20:4n-6/20:3n-6, and 22:6n-3/20:5n-3. Multiple linear regressions adjusted for relevant confounders and corrected for multiple testing were conducted to determine the association between S-PLFA, desaturation indices, and indicators of adiposity. SCD-16 (β = 0.034, P = 0.001, q = 0.014), palmitoleic acid (β = 0.031, P = 0.001, q = 0.014), and dihomo-γ-linolenic acid (β = 0.043, P = 0.000, q = 0.0002) were positively associated with BMI. Total n-6 PUFAs (β = 1.497, P = 0.047, q = 0.22) and the ratio of n-6/n-3 PUFAs (β = 0.034, P = 0.040, q = 0.19) were positively associated with WHR, while odd-chain FAs (pentadecanoic and heptadecanoic acid) showed negative associations with all the adiposity indicators. In conclusion, increased endogenous synthesis of palmitoleic acid and a high n-6/n-3 ratio are associated with increased adiposity, while odd-chain FAs are associated with decreased adiposity. Further studies are needed to determine the potential causality behind these associations.
Health and Social-Physical Environment Profiles Among Older Adults Living Alone: Associations With Depressive Symptoms.

OBJECTIVES We examined differences in depressive symptoms among people 65 and older who live alone, exploring whether these differences are associated with both health and environmental contexts. METHOD Data are from the 2006 wave of Health Retirement Study (N = 2,956, age range: 65-104). We used a two-step cluster analytical approach to identify subgroups of health-limitation profiles and environmental profiles. Logistic regression models determined associations between subgroups and depressive symptoms. RESULTS Cluster analysis identified four health-profile subgroups (sensory-cognitively impaired, physically impaired, multiply impaired, and healthy) and three different physical-social environmental-profile subgroups (physically average/socially unsupported, physically unsupported/socially supported, and physically supported/socially above average). Compared to members of healthier groups, members of the multiply impaired group were the oldest and were more likely both to live in senior housing and to have depressive symptoms if they lived in a physically average/socially unsupported environment. Members of the sensory-cognitively impaired group were more likely to have depressive symptoms when they lived in a physically unsupported/socially supported environment. DISCUSSION Findings regarding the range of both health and social-physical environmental profiles as well as the associations between person-environment profiles combinations (fit) and depressive symptomatology have important policy and intervention implications.