Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of In-Season Strength Maintenance Training Frequency in Professional Soccer Players

Rønnestad, BR, Nymark, BS, and Raastad, T. Effects of in-season strength maintenance training frequency in professional soccer players. J Strength Cond Res 25(10): 2653–2660, 2011–The aim of the present study was to examine the effect of in-season strength maintenance training frequency on strength, jump height, and 40-m sprint performance in professional soccer players. The players performed the same strength training program twice a week during a 10-week preparatory period. In-season, one group of players performed 1 strength maintenance training session per week (group 2 + 1; n = 7), whereas the other group performed 1 session every second week (group 2 + 0.5; n = 7). Only the strength training frequency during the in-season differed between the groups, whereas the exercise, sets and number of repetition maximum as well as soccer sessions were similar in the 2 groups. The preseason strength training resulted in an increased strength, sprint, and jump height (p < 0.05). During the first 12 weeks of the in-season, the initial gain in strength and 40-m sprint performance was maintained in group 2 + 1, whereas both strength and sprint performance were reduced in group 2 + 0.5 (p < 0.05). There was no statistical significant change in jump height in any of the 2 groups during the first 12 weeks of the in-season. In conclusion, performing 1 weekly strength maintenance session during the first 12 weeks of the in-season allowed professional soccer players to maintain the improved strength, sprint, and jump performance achieved during a preceding 10-week preparatory period. On the other hand, performing only 1 strength maintenance session every second week during the in-season resulted in reduced leg strength and 40-m sprint performance. The practical recommendation from the present study is that during a 12-week period, 1 strength maintenance session per week may be sufficient to maintain initial gain in strength and sprint performance achieved during a preceding preparatory period.
Ex vivo biomechanical comparison of a 3.5 mm locking compression plate applied cranially and a 2.7 mm locking compression plate applied medially in a gap model of the distal aspect of the canine radius.

OBJECTIVE To compare a medially applied 2.7 mm locking compression plate (LCP) to a cranially applied 3.5 mm LCP in a cadaveric distal radial fracture gap model. STUDY DESIGN In vitro mechanical testing of paired cadaveric limbs SAMPLE POPULATION Paired radii (n = 8) stabilized with either a 2.7 mm LCP medially or a 3.5 mm LCP cranially. METHODS Simulated distal radial comminuted fractures were created and stabilized with an LCP plate on the cranial surface in 1 limb, and on the medial surface in the contralateral limb. Gap stiffness, gap strain, and failure properties were compared between cranial and medial plate positions. Limb constructs were axially loaded, cyclically through 4 conditions that allowed mediolateral or craniocaudal bending at walk and trot loads, before monotonic failure loading. The effects of plate position on mechanical variables were assessed using paired t-tests. RESULTS Gap stiffness was greater for cranial plate constructs than medial plate constructs for axial loading with mediolateral bending, but lower with craniocaudal bending. However, in loading that facilitated craniocaudal bending the medial plate construct also had bending apparent in the mediolateral direction. Gap strains for the different conditions followed similar trends as stiffness. Cranial plate constructs had significantly higher monotonic stiffness, yield, and failure loads. CONCLUSION The larger, cranially applied LCP was biomechanically superior to the smaller, medially applied LCP in our distal radial fracture gap model, however the medial plate was superior to the cranial plate in cyclic loading allowing craniocaudal bending.
Suppression of the Floral Activator Hd3a Is the Principal Cause of the Night Break Effect in Rice[W]

A short exposure to light in the middle of the night causes inhibition of flowering in short-day plants. This phenomenon is called night break (NB) and has been used extensively as a tool to study the photoperiodic control of flowering for many years. However, at the molecular level, very little is known about this phenomenon. In rice (Oryza sativa), 10 min of light exposure in the middle of a 14-h night caused a clear delay in flowering. A single NB strongly suppressed the mRNA of Hd3a, a homolog of Arabidopsis thaliana FLOWERING LOCUS T (FT), whereas the mRNAs of OsGI and Hd1 were not affected. The NB effect on Hd3a mRNA was maximal in the middle of the 14-h night. The phyB mutation abolished the NB effect on flowering and Hd3a mRNA, indicating that the NB effect was mediated by phytochrome B. Because expression of the other FT-like genes was very low and not appreciably affected by NB, our results strongly suggest that the suppression of Hd3a mRNA is the principal cause of the NB effect on flowering in rice.
Secondary acute myeloid leukemia after successful treatment for osteosarcoma

Secondary acute myeloid leukemia (sAML) is a rare complication following chemotherapy for osteogenic sarcoma. However, the exact offending drug is difficult to prove as there is no consistent data. It usually develops 2 years after completion of therapy. We report a case of sAML that developed within 8 months of completing the treatment. The patient was treated with cisplatin, doxorubicin and high-dose methotreaxate followed by surgery (amputation). Eight months after completion of therapy, while on follow-up, he presented with leukocytosis and thrombocytopenia and confirmed to have AML.
Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a

Three chimpanzees persistently infected with hepatitis C virus of genotype II/1b were challenged with hepatitis C virus of genotype III/2a and 6 wk later with hepatitis C virus of genotype I/1a. They were tested for titers of total and genotype‐specific hepatitis C virus RNA, as well as for serum transaminase levels, until 52 wk after the first challenge. One chimpanzee (CH489) with intermittent low hepatitis C virus RNA titers of genotype II/1b in serum was superinfected with hepatitis C virus of genotype III/2a between wk 1 and 7 after the challenge; superinfection was accompanied by fluctuating high transaminase levels. Later, the animal was superinfected with hepatitis C virus of genotype I/1a. Superinfection was accompanied by persistently high transaminase levels immediately after the challenge. Hepatitis C virus of genotype I/1a persisted, whereas hepatitis C virus of genotype II/1b was undetectable 22 wk after the challenge and thereafter. In another chimpanzee (CH353) with intermittent low hepatitis C virus RNA titers of genotype II/1b, hepatitis C virus of genotype III/2a induced fluctuating high levels of serum transaminases without revealing itself in serum. Then, HCV of genotype I/1a superinfected her, induced persistently high transaminase levels and took over HCV of genotype II/1b at 22 wk after the challenge and thereafter. The third chimpanzee (CH451) with persistently high HCV RNA titers of genotype II/1b did not reveal HCV RNA of genotype III/2a in serum after the challenge, although transaminases sharply increased. Low‐titered HCV RNA of genotype I/1a was detected at 18 wk after the challenge. He continued to have elevated transaminase levels and high‐titered HCV RNA of genotype II/1b throughout the observation period. These results indicate superinfection with HCV of different genotypes in chimpanzees, newly introduced HCV replacing or being expelled by the predecessor HCV with each infection inducing an episode of liver injury. (Hepatology 1994;20:1131–1136).
A framework for design and validation of face detection systems

A framework for hardware design and validation of face detection systems is discussed. The design begins at a high-level of abstraction by using a software library as the golden reference model. The golden reference model and the baseline model (model under validation) are converted to a transaction level (TLM) description or a register transfer level (RTL) description. The degree of similarity of the detected faces is used to determine whether the model under validation fulfills the prescribed design requirements. The framework is designed for real time high resolution image processing applications and is based on the universal verification methodology (UVM). As a case study, the framework was applied to validate a C++ baseline model written to implement the OpenCV library considered as the golden reference model. In this case both models have been converted to TLM and thus the time required for determining whether the baseline model is valid or not is significantly reduced. Thus one can decide as early as possible if one must proceed with the conversion of baseline model to RTL based on the result of the TLM validation test.
Effects of diurnal variation and prolonged refractoriness on repeated measurements of airways responsiveness to methacholine.

BACKGROUND--A number of studies have suggested that diurnal variation in airways responsiveness underlies the circadian rhythm of ventilatory function in asthma. Measurements of airways responsiveness are therefore often performed at standardised times in order to avoid this possible effect, but this is not practical for epidemiological studies. Refractoriness to methacholine has also been reported and this, too, could confound the results of methacholine tests repeated over short intervals. This investigation was carried out to evaluate the possible magnitude of diurnal variation and refractoriness in repeated measures of airways responsiveness to methacholine. METHODS--To investigate diurnal variation in airways responsiveness, 24 asthmatic subjects aged 18-45 underwent five methacholine tests over three days which were not necessarily consecutive: day 1 at 08:00 hours; day 2 at 08:00 hours, 14:00 hours, 20:00 hours; day 3 at 20:00 hours. To investigate refractoriness a retrospective analysis was undertaken of all paired methacholine tests performed in individuals within our unit between 1984 and 1990 where there had been no intervention likely to affect the results. RESULTS--The first investigation revealed no diurnal change in airways responsiveness although there was a change in FEV1. Mean PD20 did, however, increase 1.57 fold from 08:00 hours on day 1 to 08:00 hours on day 2 for subjects studied on consecutive days. The second investigation confirmed that a test interval of up to 24 hours (but not of 48 or more hours) was associated with a refractory index (PD20 test 2/PD20 test 1) of > 1. CONCLUSIONS--No diurnal variation in airways responsiveness was detected for measurements made between 08:00 hours and 20:00 hours, but an interval between successive tests of up to 24 hours was associated with refractoriness. Diurnal variation is not likely to exert an important confounding effect on methacholine tests carried out between 08:00 hours and 20:00 hours, but confounding could result from refractoriness if tests are repeated at intervals up to 24 hours.
Fall in Earth's Magnetic Field Is Erratic

Earth's magnetic field has decayed by about 5% per century since measurements began in 1840. Directional measurements predate those of intensity by more than 250 years, and we combined the global model of directions with paleomagnetic intensity measurements to estimate the fall in strength for this earlier period (1590 to 1840 A.D.). We found that magnetic field strength was nearly constant throughout this time, in contrast to the later period. Extrapolating to the core surface showed that the fall in strength originated in patches of reverse magnetic flux in the Southern Hemisphere. These patches were detectable by directional data alone; the pre-1840 model showed little or no evidence of them, supporting the conclusion of a steady dipole up to 1840.
On Lower and Upper Bounds in Smooth and Strongly Convex Optimization

We develop a novel framework to study smooth and strongly convex optimization algorithms. Focusing on quadratic functions we are able to examine optimization algorithms as a recursive application of linear operators. This, in turn, reveals a powerful connection between a class of optimization algorithms and the analytic theory of polynomials whereby new lower and upper bounds are derived. Whereas existing lower bounds for this setting are only valid when the dimensionality scales with the number of iterations, our lower bound holds in the natural regime where the dimensionality is fixed. Lastly, expressing it as an optimal solution for the corresponding optimization problem over polynomials, as formulated by our framework, we present a novel systematic derivation of Nesterov's well-known Accelerated Gradient Descent method. This rather natural interpretation of AGD contrasts with earlier ones which lacked a simple, yet solid, motivation.
Postural and Anticonvulsant Effects of Inhibition of the Rat Subthalamic Nucleus

The subthalamic nucleus (STN) plays a crucial role as a regulator of basal ganglia outflow by providing excitatory glutamatergic input into the two output nuclei of the basal ganglia, substantia nigra pars reticulata (SNpr), and entopeduncular nucleus. This study examined the effects of suppressing activity in the STN of the awake, behaving rat. Specifically, we evaluated the effects of unilateral and bilateral focal inhibition of STN on posture, locomotion, and susceptibility to limbic motor seizures. Unilateral microinjection of a GABAA receptor agonist (muscimol, 200 pmol) into STN produced a site-dependent contralaterally directed postural asymmetry without locomotor activation. This effect differed from responses produced by the same dose of muscimol placed into SNpr, which included locomotor activation in addition to contralaterally directed postural asymmetry. Locomotor activation and postural asymmetry were obtained also after blockade of glutamate transmission in SNpr by the unilateral application of kynurenate (100 nmol). Our observation that STN inhibition did not induce the locomotor activation characteristic of SNpr inhibition suggests that there are glutamatergic inputs to SNpr, other than those from STN, that are responsible for controlling locomotion. Bilateral, but not unilateral, injection of muscimol (200 pmol) into STN protected against limbic motor seizures evoked either by intravenous bicuculline or by focal application of bicuculline into anterior piriform cortex (area tempestas). These results demonstrate that focal inhibition of STN reproduces the postural asymmetry and anticonvulsant actions that are obtained with the inhibition of SNpr. This provides behavioral support for the concept that STN contributes a crucial tonic excitatory (glutamatergic) drive to the rat SNpr.
Prevalence and cost of hospital medical errors in the general and elderly United States populations

Abstract Objective: The primary objective of this study was to quantify the differences in the prevalence rate and costs of hospital medical errors between the general population and an elderly population aged ≥65 years. Methods: Methods from an actuarial study of medical errors were modified to identify medical errors in the Premier Hospital Database using data from 2009. Visits with more than four medical errors were removed from the population to avoid over-estimation of cost. Prevalence rates were calculated based on the total number of inpatient visits. Results: There were 3,466,596 total inpatient visits in 2009. Of these, 1,230,836 (36%) occurred in people aged ≥ 65. The prevalence rate was 49 medical errors per 1000 inpatient visits in the general cohort and 79 medical errors per 1000 inpatient visits for the elderly cohort. The top 10 medical errors accounted for more than 80% of the total in the general cohort and the 65+ cohort. The most costly medical error for the general population was postoperative infection ($569,287,000). Pressure ulcers were most costly ($347,166,257) in the elderly population. Limitations: This study was conducted with a hospital administrative database, and assumptions were necessary to identify medical errors in the database. Further, there was no method to identify errors of omission or misdiagnoses within the database. Conclusions: This study indicates that prevalence of hospital medical errors for the elderly is greater than the general population and the associated cost of medical errors in the elderly population is quite substantial. Hospitals which further focus their attention on medical errors in the elderly population may see a significant reduction in costs due to medical errors as a disproportionate percentage of medical errors occur in this age group.
Back pain and its correlates among workers in family care.

In order to assess the prevalence of back pain problems among family care workers, and the association of back pain with selected variables, a cross-sectional survey among the 4723 employees of the largest Flemish organization for family care was conducted. A self-administered questionnaire comparable to the standardized Nordic questionnaire on musculoskeletal symptoms was distributed to all employees of the organization. The response rate was 90 per cent (n = 4256) and the study population was almost uniformly composed of females (99.8 per cent). The period prevalence (12 months) amounted to 63 per cent (95 per cent CI: 61.7-64.6) and the point prevalence to 18 per cent (95 per cent CI: 16.5-18.8). Among the respondents suffering from back pain during the past year, 72 per cent suffered from repeated episodes of pain. In 82 per cent low back pain was involved. Twenty-nine per cent of the complaints interrupted their work during the past year, yielding a total number of 23,396 days of sick leave. The mean sick leave for back pain was 36 days and the median 15 days. The frequency of back pain was found to vary according to the regional departments to which the employees belonged, some sections experiencing up to 36 per cent higher period prevalences than the units with the lowest figures. (ABSTRACT TRUNCATED AT 250 WORDS)
EFFECTS OF EPISTASIS ON INFECTIVITY RANGE DURING HOST-PARASITE COEVOLUTION

Understanding how parasites adapt to changes in host resistance is crucial to evolutionary epidemiology. Experimental studies have demonstrated that parasites are more capable of adapting to gradual, rather than sudden changes in host phenotype, as the latter may require multiple mutations that are unlikely to arise simultaneously. A key, but as yet unexplored factor is precisely how interactions between mutations (epistasis) affect parasite evolution. Here, we investigate this phenomenon in the context of infectivity range, where parasites may experience selection to infect broader sets of genotypes. When epistasis is strongly positive, we find that parasites are unlikely to evolve broader infectivity ranges if hosts exhibit sudden, rather than gradual changes in phenotype, in close agreement with empirical observations. This is due to a low probability of fixing multiple mutations that individually confer no immediate advantage. When epistasis is weaker, parasites are more likely to evolve broader infectivity ranges if hosts make sudden changes in phenotype, which can be explained by a balance between mutation supply and selection. Thus, we demonstrate that both the rate of phenotypic change in hosts and the form of epistasis between mutations in parasites are crucial in shaping the evolution of infectivity range.
Influence of selected sociodemographic factors on psychosocial workload of nurses and association of this burden with absenteeism at work.

BACKGROUND The aim of this study has been to determine if sociodemographic factors: age, sex and duration of employment as well as the presence of chronic comorbidities exert significant effect on subjective assessment of psychosocial working conditions of nurses. Moreover, we analyzed whether the abovementioned variables influenced the level of absenteeism at work during a year preceding the study. MATERIAL AND METHODS The study, conducted between December 2012 and January 2013, included 789 nurses employed at public and private healthcare institutions in Białystok. The participants were surveyed by means of the "Psychosocial Working Conditions" questionnaire. RESULTS Women accounted for significantly higher scores of the Desired Changes Scale and significantly lower values of the Well-being Scale as compared to men. Respondents' age and duration of employment correlated significantly with the scores of the Demands and Desired Changes Scales. Moreover, we documented significant inverse correlations between the age and tenure and the scores of the Social Support and Well-being Scales. Furthermore, duration of employment was inversely correlated with the results of the Control Scale. The respondents with chronic conditions showed significantly higher scores of the Desired Changes Scale and significantly lower values of the Control and Well-being Scales. We found an inverse correlation between the number of sick leave days and the value of the Well-being Scale, which was also the case with a subset of nurses without chronic conditions. CONCLUSIONS Similar to other professional groups, a nursing team management requires the use of human resources management techniques and identification of a person being responsible for coordination of the group and diagnosis of its psychosocial needs.
The Role of Arterioles and the Microcirculation in the Development of Vasospasm after Aneurysmal SAH

Cerebral vasospasm of the major cerebral arteries, which is characterized by angiographic narrowing of those vessels, had been recognized as a main contributor to delayed cerebral ischemia (DCI) in subarachnoid hemorrhage (SAH) patients. However, the CONSCIOUS-1 trial revealed that clazosentan could not improve mortality or clinical outcome in spite of successful reduction of relative risk in angiographic vasospasm. This result indicates that the pathophysiology underlying DCI is multifactorial and that other pathophysiological factors, which are independent of angiographic vasospasm, can contribute to the outcome. Recent studies have focused on microcirculatory disturbance, such as microthrombosis and arteriolar constriction, as a factor affecting cerebral ischemia after SAH. Reports detecting microthrombosis and arteriolar constriction will be reviewed, and the role of the microcirculation on cerebral ischemia during vasospasm after SAH will be discussed.
How heritable is individual susceptibility to death? The results of an analysis of survival data on Danish, Swedish and Finnish twins

Abstract Molecular epidemiological studies confirm a substantial contribution of individual genes to variability in susceptibility to disease and death for humans. To evaluate the contribution of all genes to susceptibility and to estimate individual survival characteristics, survival data on related individuals (eg twins or other relatives) are needed. Correlated gamma-frailty models of bivariate survival are used in a joint analysis of survival data on more than 31 000 pairs of Danish, Swedish and Finnish male and female twins using the maximum likelihood method. Additive decomposition of frailty into genetic and environmental components is used to estimate heritability in frailty. The estimate of the standard deviation of frailty from the pooled data is about 1.5. The hypothesis that variance in frailty and correlations of frailty for twins are similar in the data from all three countries is accepted. The estimate of narrow-sense heritability in frailty is about 0.5. The age trajectories of individual hazards are evaluated for all three populations of twins and both sexes. The results of our analysis confirm the presence of genetic infiuences on individual frailty and longevity. They also suggest that the mechanism of these genetic infiuences may be similar for the three Scandinavian countries. Furthermore, results indicate that the increase in individual hazard with age is more rapid than predicted by traditional demographic life tables.