Miracle-dz/UniFAR-FTUs huggingface dataset:
miR-486-5p expression pattern in esophageal squamous cell carcinoma, gastric cancer and its prognostic value

Micro RNA (miR)-486-5p is often aberrantly expressed in human cancers. The aim of this study was to identify the prognostic value of miR-486-5p expression in digestive system cancers. Tissue microarrays were constructed with 680 samples including 185 esophageal squamous cell carcinomas (ESCCs), 90 gastric adenocarcinomas (GCs), and 60 digestive system cancer tissues from 10 ESCC, 10 GC, 10 colon, 10 rectum, 10 liver, 10 pancreatic cancer, and corresponding normal tissues. Twenty normal digestive system mucosa tissues from healthy volunteers were included as normal controls. In GC, miR-486-5p expression was decreased in 62.8% of cases (59/94), increased in 33.0% (31/94), and unchanged in 4.2% (4/94); in ESCC its expression was decreased in 66.2% (129/195), increased in 32.3% (63/195), and unchanged in 1.5% (3/195). Expression of miR-486-5p was decreased in 12, and increased in 8, of 20 cases of colon or rectum cancer; decreased in 6, and increased in 4, of 10 cases of liver cancer; and decreased in 8, and increased in 2, of 10 cases of pancreatic cancer. Multivariate and univariate regression analysis demonstrated that low/unchanged miR-486-5p predicted poor prognosis in ESCC (hazard ratio [HR], 4.32; 95% confidence interval [CI], 2.62–7.14; P < 0.001; HR, 3.88; 95% CI, 2.43–6.22; P < 0.001, respectively) and GC (HR, 2.46; 95% CI, 1.35–4.50; P = 0.003; HR, 2.55; 95% CI, 1.39–4.69; P = 0.002, respectively). MiR-486-5p might therefore be an independent tumor marker for evaluating prognosis in patients with ESCC or GC.
Towards an Ontology of Ongoing Thought

Functional outcomes of ongoing thought show both costs and benefits. Yet, the reason for its heterogeneity remains unclear. The executive failure and representational accounts stemmed from different psychological research approaches to understand ongoing thought. The executive failure account examines why changes in ongoing thought happen, while the representational account seeks to explain how humans generate ongoing thought. The attentional system and the default mode network are the common neural processes of both theoretical accounts, but interacting in a contradicting manner. The two accounts can be seen as competing theories of ongoing thought. However, in the family resemblance view (Seli et al., 2018), the two theoretical accounts potentially serve as two component processes of one phenomenon. One possible solution to this conflict could be that under different global neural configurations, the two networks support different cognitive functions. The thesis sets out to present evidence supporting of the family resemblance view and to begin research on the ontology of the component processes in ongoing thought. Neural cognitive hierarchy is the potential explanation of the heterogeneity. The current thesis adopts sparse canonical correlation analysis to incorporate the neural and behavioural aspects of ongoing thought. The data suggests ongoing thought is a collective phenomenon with many types of experience driven by the connectivity patterns in the default mode network. Each type of experience associated with their unique functional outcomes and neural hierarchies at the whole-brain level. Cognitive flexibility and the balance of segregation and integration between the transmodal systems and the rest of the cortex determines the immersive details. The current findings suggested the importance of whole-brain neural hierarchies to ongoing thought. The confirmation of these trait level findings at a state level are necessary to gain more insights into the architecture of the component processes.
HbA1C Variability and the Risk of Renal Status Progression in Diabetes Mellitus: A Meta-Analysis

Objective To explore the association between glycated hemoglobin (A1C) variability and renal disease progression in patients with diabetes mellitus. Methods A comprehensive search was performed using the PubMed and Embase databases (up to April 26, 2014). The hazard ratio (HR) was pooled per unit increase in the standard deviation of A1C (A1C-SD) to evaluate the dose-response relationship between A1C-SD and the risk of nephropathy. Results Eight studies with a total of 17,758 subjects provided the HR for A1C-SD and were included in the final meta-analysis. The pooled HR results demonstrated that A1C-SD was significantly associated with the progression of renal status (HR for both T1DM and T2DM 1.43, 95% confidence interval [CI] 1.24–1.64; HR for T1DM 1.70, 95%CI 1.41–2.05; HR for T2DM 1.20, 95%CI 1.12–1.28). A1C-SD was significantly correlated with new-onset microalbuminuria (HR for T1DM 1.63, 95%CI 1.28–2.07; HR for T2DM 1.23, 95%CI 1.08–1.39). These outcomes were also supported in subgroup analyses. Furthermore, sensitivity analyses demonstrated that the results were robust. Conclusions A1C variability is independently associated with the development of microalbuminuria and the progression of renal status in both type 1 and 2 diabetes patients. A standard method for measuring A1C variability is essential for further and deeper analyses. In addition, future studies should assess the effect of reducing A1C variability on nephropathy complication.
Strategic Entrepreneurship and Performance of Small and Medium Scale Enterprises in Aba Metropolis

Strategic entrepreneurship has become dominant in the contemporary world and it is considered an effective tool for economic. Small and medium scale enterprises (SMEs) in Aba metropolis are faced with issues like inadequate information about strategic entrepreneurship, low entrepreneurial innovation which had resulted into low productivity and inefficiency in profit maximization. Little attention have been given into how strategic entrepreneurship contributes to performance of SMEs in Aba metropolis, Abia State. This study examined the effect of strategic entrepreneurship on performance of selected SMEs in Aba metropolis. The study adopted the survey research design. The population of the study consisted of 231 owner/managers of the selected SMEs in the manufacturing, the finance, health and the food and beverages sectors in Aba metropolis. The total enumeration method of sampling was used and data were gathered through the use of a questionnaire. The instrument was validated and the KMO values were greater that 0.5 while the reliability test was 0.875. Data were analyzed using simple linear regression analysis. The results revealed that strategic entrepreneurship variables have effects on the performance variables. The study concluded that strategic entrepreneurship plays an important role in enhancing the performance of SMEs in Aba metropolis. It was therefore recommended that SMEs should pay critical attention to the adoption of strategic entrepreneurship due to its positive effect on performance.
Secondary haemophagocytic lymphohistiocytosis: Experience from the Uppsala University Hospital

Abstract Background. Haemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome characterized by fever, hepatosplenomegaly, cytopenia, and progressive multiple-organ failure. HLH in adults is often secondary to autoimmune diseases, cancer, or infections in contrast to familial HLH. Treatment of secondary HLH is directed against the triggering disease in addition to immunosuppressive therapy, the latter commonly according to the HLH-2004 protocol. Methods. We conducted a retrospective study to identify triggering diseases, disease-specific and immunosuppressive therapy administered, and prognosis in adult patients with secondary HLH. Patient data were collected from October 2010 to January 2015. Results. Ten adult patients with secondary HLH were identified. Seven were men, and the median age at diagnosis was 62 years. Five cases were triggered by malignant disease and five by infection. The median patient fulfilled five of the eight HLH-2004 diagnostic criteria. All patients fulfilled the criteria fever, cytopenia, and ferritin >500 µg/L. Median time from hospital admission to HLH diagnosis was 20 days. Four patients received immunosuppressive therapy according to the HLH-2004 protocol. The prognosis was dismal, especially for the patients with malignancy-associated HLH, of whom all died. Conclusion.HLH should be suspected in patients who present with fever, cytopenia, and ferritin >500 µg/L. Secondary HLH has a dismal prognosis. None of the patients with HLH triggered by malignancy survived. Achieving remission of the triggering disease seems to be important for a favourable outcome as, in all surviving patients, the haemophagocytic syndrome resolved after remission of the underlying infection.
Seasonal Plasticity in Junonia coenia (Nymphalidae): Linking Wing Color, Temperature Dynamics, and Behavior

ABSTRACT. The common buckeye, Junonia coenia (Hübner), is a North American nymphalid that shows seasonal wing color plasticity. Throughout much of its range the ventral hindwings are tan in the spring and summer and dark red in autumn. Although this species has long been used as a model to study the physiology and genetics of plasticity, the function of its seasonal color variation is still largely unknown. Here we investigate the effect of buckeye wing color on wing and body temperature and ask to what extent seasonal plasticity is associated with behavioral differences. By using real time infrared imaging of different seasonal morphs from a laboratory colony of North Carolina J. coenia, we observed that red autumnal butterflies warm up faster and reach higher final temperatures than tan summer butterflies. Furthermore, behavioral trials at field sites revealed that red butterflies are less physically active than tan butterflies. Based on our findings, we propose that the dark red wing coloration of autumn morphs could be useful for helping individuals reach higher body temperatures faster while basking on colder days. We also speculate that lower activity levels of autumnal butterflies may help conserve energy.
Arabic Text Classification Using Support Vector Machines

Text classification (TC) is the process of classifying documents into a predefined set of categories based on their content. Arabic language is highly inflectional and derivational language which makes text mining a complex task. In this paper we applied the Support Vector Machines (SVM) model in classifying Arabic text documents. The results compared with the other traditional classifiers Bayes classifier, K-Nearest Neighbor classifier and Rocchio classifier. Two experiments used to test the different classifiers. The first uses the training set as the test set, and the second uses Leave one testing method. Experimental results performed on a set of 1132 document show that Rocchio classifier gives better results when the size of feature set is small while SVM outperform the other classifiers when the size of the feature set is large enough. Classification rate exceeds 90% when using more than 4000 feature. Leave one method gives more realistic results over the use of training set as a test set.
Self-regulatory mode (locomotion and assessment), well-being (subjective and psychological), and exercise behavior (frequency and intensity) in relation to high school pupils’ academic achievement

Background. Self-regulation is the procedure implemented by an individual striving to reach a goal and consists of two inter-related strategies: assessment and locomotion. Moreover, both subjective and psychological well-being along exercise behaviour might also play a role on adolescents academic achievement. Method. Participants were 160 Swedish high school pupils (111 boys and 49 girls) with an age mean of 17.74 (sd = 1.29). We used the Regulatory Mode Questionnaire to measure self-regulation strategies (i.e., locomotion and assessment). Well-being was measured using Ryff’s Psychological Well-Being Scales short version, the Temporal Satisfaction with Life Scale, and the Positive Affect and Negative Affect Schedule. Exercise behaviour was self-reported using questions pertaining to frequency and intensity of exercise compliance. Academic achievement was operationalized through the pupils’ mean value of final grades in Swedish, Mathematics, English, and Physical Education. Both correlation and regressions analyses were conducted. Results. Academic achievement was positively related to assessment, well-being, and frequent/intensive exercise behaviour. Assessment was, however, negatively related to well-being. Locomotion on the other hand was positively associated to well-being and also to exercise behaviour. Conclusions. The results suggest a dual (in)direct model to increase pupils’ academic achievement and well-being—assessment being directly related to higher academic achievement, while locomotion is related to frequently exercising and well-being, which in turn, increase academic achievement.
A novel DNN-HMM-based approach for extracting single loads from aggregate power signals

This paper presents a new supervised approach to extract the power trace of individual loads from single channel aggregate power signals in non-intrusive load monitoring (NILM) systems. Recent approaches to this source separation problem are based on factorial hidden Markov models (FHMM). Drawbacks are the needed knowledge of HMM models for all loads, what is infeasible for large buildings, and the large combinatorial complexity. Our approach trains HMM with two emission probabilities, one for the single load to be extracted and the other for the aggregate power signal. A Gaussian distribution is used to model observations of the single load whereas observations of the aggregate signal are modeled with a Deep Neural Network (DNN). By doing so, a single load can be extracted from the aggregate power signal without knowledge of the remaining loads. The performance of the algorithm is evaluated on the Reference Energy Disaggregation (REDD) dataset.
Far-Infrared Properties of M Dwarfs

We report the mid- and far-infrared properties of nearby M dwarfs. Spitzer MIPS measurements were obtained for a sample of 62 stars at 24 μm, with subsamples of 41 and 20 stars observed at 70 and 160 μm, respectively. We compare the results with current models of M star photospheres and look for indications of circumstellar dust in the form of significant deviations of K-[24 μm] colors and 70 μm/24 μm flux ratios from the average M star values. At 24 μm, all 62 of the targets were detected; 70 μm detections were achieved for 20 targets in the subsample observed, and no detections were seen in the 160 μm subsample. No clear far-infrared excesses were detected in our sample. The average far-infrared excess relative to the photospheric emission of the M stars is at least 4 times smaller than the similar average for a sample of solar-type stars. However, this limit allows the average fractional infrared luminosity in the M-star sample to be similar to that for more massive stars. We have also set low limits (10-4 to 10-9 M⊕ depending on location) for the maximum mass of dust possible around our stars.
Openly gay athletes: contesting hegemonic masculinity in a homophobic environment: Eric Anderson

This research provides the first look into the experiences of openly gay male team sport athletes on ostensibly all-heterosexual teams. Although openly gay athletes were free from physical harassment, in the absence of a formal ban against gay athletes, sport resisted their acceptance and attempted to remain a site of orthodox masculine production by creating a culture of silence surrounding gay athleticism, by segmenting gay men’s identities, and by persistently using homophobic discourse to discredit homosexuality in general. Sports attempt to tolerate gay male athletes when they contribute to the overarching ethos of sport—winning—but try to taint the creation of a gay identity within sport that would see homosexuality and athleticism as compatible. Still, by proving themselves successful in sport, and meeting most other mandates of hegemonic masculinity except for their sexual identity, gay male athletes show that hegemony is not seamless and that there is a possibility of softening hegemonic masculinity in the sporting realm.
Employment Protection, International Specialization, and Innovation

We develop a model to analyze the implications of firing costs on incentives for R & D and international specialization. The key idea is that, to avoid paying firing costs, the country with a rigid labor market will tend to produce relatively secure goods, at a late stage of their product life cycle. Under international trade, an international product cycle emerges where, roughly, new goods are first produced in the low firing cost country and then move to the high firing cost country. We show that in the closed economy, an increase in firing costs does not necessarily imply a reduction in R & D; it crucially depends on the riskiness of R & D activity relative to production activity. In the open economy, however, an increase in firing cost is much more likely to reduce R & D intensity.
Principals and stress: Few coping strategies for abundant stressors

Various job demands continue to be very stressing and exhausting for school administrators who have to work under unprecedented pressure. This qualitative study explores the various stressors school administrators experience and the coping strategies they utilize to manage their stress. Findings show that the various stressors experienced by the school administrators do affect their job performance and their own wellbeing. Principals mentioned three main types of stressors related to work, relationships and time. They also experienced some unpleasant feelings in response to these stressors such as guilt, a sense of unfairness, loneliness, or disappointment. However, their coping strategies comprised of spending time with loved ones and having an outlet outside work. Implications for social emotional skills-based professional development programmes for school administrators are discussed.
Macroeconomic Adjustment to Monetary Union

The move to monetary union in Europe led to convergence of interest rates among the participating countries. This was associated with notable cross-country differences in the behaviour of key macroeconomic aggregates. Compared to the low interest rate countries, former high interest rate countries experienced a boom in domestic demand, a deterioration of the current account and appreciation of the real exchange rate. This paper documents the key stylised facts of this experience and provides a compact two-country model, based on the Blanchard-Yaari setup, to analyze this phenomenon. This model, though simple, is able to broadly capture the main qualitative features of the adjustment. Using this model, we show that the creation of the monetary union leads to an increase in welfare for all generations in both country groups.
NVMKV: A Scalable and Lightweight Flash Aware Key-Value Store

State-of-the-art flash-optimized KV stores frequently rely upon a log structure and/or compaction-based strategy to optimally organize content on flash. However, these strategies lead to excessive I/O, beyond the write amplification generated within the flash itself, with both the application and the flash device constantly rearranging data. In this paper, we explore the other extreme in the design space: minimal data management at the KV store and heavy reliance on the Flash Translation Layer (FTL) capabilities. NVMKV is a scalable and lightweight KV store that leverages advanced capabilities that are becoming available in modern FTLs. We demonstrate that NVMKV (i) performs KV operations at close to native device access speeds for get operations, (ii) outperforms state of the art KV stores by 50%-300%, (iii) significantly improves performance predictability for the YCSB KV benchmark when compared with the popular LevelDB KV store, and (iv) reduces data written to flash by as much as 1.7X and 29X for sequential and random write workloads relative to LevelDB, thereby dramatically increasing device lifetime.
Exact 2-point function in Hermitian matrix model

J. Harer and D. Zagier have found a strikingly simple generating function (1, 2) for exact (all-genera) 1-point correlators in the Gaussian Hermitian matrix model. In this paper we generalize their result to 2-point correlators, using Toda integrability of the model. Remarkably, this exact 2-point correlation function turns out to be an elementary function — arctangent. Relation to the standard 2-point resolvents is pointed out. Some attempts of generalization to 3-point and higher functions are described.
Employees’ self-determined motivation, transformational leadership and work engagement

Abstract While research on the role of employees’ characteristics as core to transformational leadership theory is burgeoning, limited research has focused on the differing aspects of employees’ self-determined motivation as mediating mechanism through which transformational leadership may impact outcomes. Drawing on the self-determined theory of motivation, we build and test a theoretical model linking employees’ perceptions of transformational leadership with engagement through an intervening variable of differing aspects of employees’ self-determined motivation. Data from a sample of 155 participants revealed that employees’ perceptions of transformational leadership were positively related to employees’ self-determined motivation (intrinsic, autonomous, and controlled) and work engagement. Specifically, self-determined motivation (intrinsic, autonomous) was positively linked with work engagement while intrinsic, autonomous and controlled dimensions of self-determined motivation mediated the relationship between transformational leadership and work engagement. We discuss the theoretical and practical implications of the results.
Know Your Preferences: Self-Regulation as Need-Congruent Goal Selection

Theory and research on self-regulation is dominated by a social–cognitive perspective that places an emphasis on postdecisional (i.e., volitional) control processes of goal-maintenance in response to dual-motive conflict. In the current contribution, we focus on research on self-regulation that acknowledges the affective fundamentals of motivated action, and we highlight processes of goal selection as vital parts of self-regulation. From our perspective of motivational competence, affective and cognitive processes work together rather than oppose each other in self-regulation, rendering effortless rather than effortful goal pursuit as the hallmark of efficient human action. A precondition for such motive- and self-congruent goal pursuits is that individuals have insight into their basic preferences and (can) act accordingly. Therefore, we address capacities, such as mindfulness, which may take effect in predecisional (i.e., motivational) action phases, thereby determining all subsequent action processes.
Review Article: Good Governance, Institutions and Economic Development: Beyond the Conventional Wisdom

This article reviews comparative research on institutions and economic performance, identifying analytical gaps in the political economy of growth literature. It also examines core assumptions underpinning the good-governance approach to development. Contrasting experiences of conceptual and policy issues in East Asia and Latin America are discussed. The author suggests future scholarship in this field should distinguish between the rules and the play of the game; move beyond the property rights approach to development; stress the distributional, endogenous nature of institutions; investigate the role of informal constraints and human learning; and consider sources of credible commitment and self-enforcing growth. Focusing on some uncertainties in the accepted wisdom on good governance and development, this article furthers the consolidation of research on the political foundations of prosperity.