Miracle-dz/UniFAR-FTUs huggingface dataset:
Morphological Development of the Pulmonary Vascular Bed in Fetal Lambs

The morphological development that accompanies increasing pulmonary blood flow and decreasing pulmonary vascular resistance with advancing gestational age has not been delineated. To study this point we developed a method of comparing pulmonary arterial vessels of the same generations in fetal lambs. Pulmonary arteries were perfused with glutaraldehyde solution at pressures appropriate for gestational age and then injected with an India ink-gelatin-Micropaque mixture. Using the dissecting microscope and serially prepared sections we studied successively smaller generations of arteries. We assessed the medial width/external diameter ratio in a total of 825 vessels from six fetal lambs of 85 to 140 days gestation. In fifth generation, or resistance vessels, this ratio remained constant over the gestational period studied (N = 529, Y = 0.16, slope = 0.0003). We measured the volume of 17–34 randomly selected sections from each of the six fetuses, counted the total number of fifth and sixth generation vessels in these sections, and calculated the total number of these vessels per right lung. This number increased from 0.10 × 106 to 4.08 × 106 with increasing gestational age. The number of vessels per unit volume increased from 7.2 × 103/ml to 61.8 × 103/ml of right lung over this gestational period. The results indicate that increased pulmonary blood flow and decreased pulmonary vascular resistance with advancing gestation are due to an increase in the total number of vessels and increased vasomotor reactivity is related to an increase in the total amount of smooth muscle while the thickness of muscle in individual vessels remains constant.
The metaphors we study by: the doctorate as a journey and/or as work

The ‘journey’ metaphor has come to the fore as a way of conveying the student's experience of change, difficulty and progress in doctoral studies. The use of this metaphor is critically assessed through the application of a classic journey tale, John Bunyan's The Pilgrim's Progress, as a parallel to the doctoral process. An alternative case is then presented for considering the doctorate as a form of work, while recognising that work, in this context, is also a metaphor. There are, however, different kinds of work and thus different kinds of doctorate. Here, rather than pursuing the contemporary distinction made between ‘traditional’ and professional doctorates, it is argued that it is important to understand the doctoral student experience as multi-faceted and complex, with many variants, indicating the relevance of a range of metaphorical descriptions.
Sleep disturbance in Sanfilippo syndrome: a parental questionnaire study

Aims: To determine the incidence, manifestations, and best management of sleep disturbance in Sanfilippo syndrome (mucopolysaccharidosis (MPS) type III). Methods: Families were ascertained through the MPS societies of Australasia, the UK, and the USA. Questionnaires were sent by mail and were answered anonymously. Identical questions regarding sleep disturbance were asked about unaffected siblings to provide control data. Sleep disturbance was quantified by a total sleep disturbance score. Results: A total of 141 responses were received; 91.5% of children with Sanfilippo syndrome had sleep disturbance and this was significantly higher than for their unaffected sibs; 77.5% of parents had used medication for this problem, with melatonin and antihistamines being most commonly used. Melatonin and benzodiazepines were reported as the most efficacious. Many different environmental modifications had been employed for this problem and some parents reported success with behavioural therapies. Conclusions: Sleep disturbance is common, severe, and difficult to manage in Sanfilippo syndrome. Based on the parental responses and its safety profile, melatonin is the first line drug that should be tried. Behavioural therapy should be tried in all with Sanfilippo syndrome and sleep disturbance.
Comparison of Empirical Data from Two Honeynets and a Distributed Honeypot Network

In this paper we present empirical results and speculative analysis based on observations collected over a two month period from studies with two high interaction honeynets, deployed in a corporate and an SME (small to medium enterprise) environment, and a distributed honeypots deployment. All three networks contain a mixture of Windows and Linux hosts. We detail the architecture of the deployment and results of comparing the observations from the three environments. We analyze in detail the times between attacks on different hosts, operating systems, networks or geographical location. Even though results from honeynet deployments are reported often in the literature, this paper provides novel results analyzing traffic from three different types of networks and some initial exploratory models. This research aims to contribute to endeavours in the wider security research community to build methods, grounded on strong empirical work, for assessment of the robustness of computer-based systems in hostile environments.
PD-L1 immunohistochemical assays for assessment of therapeutic strategies involving immune checkpoint inhibitors in non-small cell lung cancer: a comparative study

Although immune checkpoints inhibitors have exhibited promising activity in clinical trials in non-small cell lung cancer (NSCLC) patients, the current programmed cell death-ligand 1 (PD-L1) assays are inconsistent in terms of the staining analysis and scoring system used. To verify the interchangeability of the available PD-L1 assays, we performed immunohistochemistry using three antibody clones used in clinical trials (22C3, SP263, and SP142) and the E1L3N clone as a laboratory developed test for 97 resected NSCLC specimens. Matched tissue microarray specimens were also stained. Staining with 22C3 yielded a greater proportion of stained tumor cells, whereas SP142 staining consistently labelled fewer tumor cells. However, when various cut-off criteria were applied, the positivity rates for PD-L1 were similar, with high concordance, under assay-specific cut-offs. Moreover, seven cases of discordant PD-L1 expression between the resected specimen and matched tissue microarray specimens were observed. In conclusion, despite of inter-assay variability of the PD-L1 status in NSCLC, the positivity rate appears to be similar under assay-specific criteria. Hence, an appropriate clinically defined algorithm or cut-off should be separately applied for each assay. Moreover, multiple biopsy specimens from different tumor areas should be obtained to reduce false results due to intratumoral heterogeneity in PD-L1 expression.
Application of Genome-Wide Single Nucleotide Polymorphism Typing: Simple Association and Beyond

The International HapMap Project and the arrival of technologies that type more than 100,000 SNPs in a single experiment have made genome-wide single nucleotide polymorphism (GW-SNP) assay a realistic endeavor. This has sparked considerable debate regarding the promise of GW-SNP typing to identify genetic association in disease. As has already been shown, this approach has the potential to localize common genetic variation underlying disease risk. The data provided from this technology also lends itself to several other lines of investigation; autozygosity mapping in consanguineous families and outbred populations, direct detection of structural variation, admixture analysis, and other population genetic approaches. In this review we will discuss the potential uses and practical application of GW-SNP typing including those above and beyond simple association testing.
Gastric neuroendocrine carcinoma arising from heterotopic pancreatic tissue

An 85 year old man presented with symptoms of dyspepsia and increase in stool frequency of two months duration. Upper endoscopy revealed an ulcer and the biopsy was interpreted as carcinoma with endocrine features. A formal distal gastrectomy was planned, but intraoperatively, because of the patient’s condition, a wedge resection was performed. Histology revealed a neuroendocrine tumour (grade 1), located mainly in the submucosa, which had caused mucosal attenuation and ulceration. Associated with the tumour and at its periphery was heterotopic pancreatic tissue composed of acini, ducts, and endocrine cells. The tumour was strongly positive for chromogranin and focally for synaptophysin. There was no associated chronic atrophic gastritis or G cell hyperplasia. A discrete focus of high grade neuroendocrine carcinoma (grade 3) within the typical (grade 1) neuroendocrine tumour was also present. This case illustrates a grade 1 neuroendocrine carcinoma, with a small grade 3 focus, arising within or intimately associated with heterotopic pancreatic tissue in the stomach. Although the two entities may be separate, their close topographical association favours the possibility of neuroendocrine carcinoma arising from the heterotopic pancreas. Pathologists should be aware of the occurrence of pancreatic heterotopia in the stomach and the association of carcinoma with it.
Colorectal cancer in young adults: A difficult challenge

Sporadic colorectal cancer (CRC) is traditionally diagnosed after the sixth decade of life, and current recommendations for surveillance include only patients older than 50 years of age. However, an increasing incidence of CRC in patients less than 40 years of age has been reported. This occurrence has been attributed to different molecular features and low suspicion of CRC in young symptomatic individuals. When confronting young-onset CRC with older patients, issues such as biological aggressiveness, stage at diagnosis and clinical outcomes seem to differ in many aspects. In the future, the identification of the molecular profile underlying the early development of sporadic CRC will help to plan tailored screening recommendations and improve management. Besides that, differential diagnosis with CRC linked with hereditary syndromes is necessary to provide adequate patient treatment and family screening. Until we find the answers to some of these doubts, doctors should raise suspicion when evaluating an young adult and be aware of this risk and consequences of a late diagnosis.
Harmonisation by Example: European Laws Against Unfair Commercial Practices

This examination of the implementation of the European Union's Directive on Unfair Commercial Practices in the United Kingdom by the Consumer Protection from Unfair Trading Regulations 2008 assesses the likely impact on the national law governing the marketing practices of rogue traders, including its ambition to simplify and extend legal protection, and the likely success of the Directive in achieving the harmonisation of the laws and practices regulating marketing in Europe. In particular, the discussion evaluates the regulatory strategy of the Directive in its attempt to secure uniform laws through the combination of principles, rules, and concrete examples of prohibited practices. The paper also investigates the likely impact of the Regulations on the private law of contract and tort and the possibilities for improvements in a consumer's personal right of redress.
Is Social Work the Best Educational Degree for Child Welfare Practitioners?

ABSTRACT The purpose of this three-year research project was to identify the educational and training needs of public child welfare case managers and recommend baccalaureate programs that would best meet those needs. Surveys, focus groups, and content analyses were used to identify the learning needs. The social work curricula were found to contain the most comprehensive match of skill development and theoretical and values content with the learning needs of case managers.
Neuromuscular control and exercise-related leg pain in triathletes.

UNLABELLED Previous studies have shown that cycling can directly influence neuromuscular control during subsequent running in some highly trained triathletes. A relationship between this altered neuromuscular control of running and musculoskeletal pain and injury has been proposed; however, this link has not been investigated. PURPOSE This study aimed to evaluate the influence of cycling on neuromuscular control during subsequent running in highly trained triathletes with and without exercise-related leg pain (ERLP). METHODS Participants were 34 highly trained triathletes: 10 triathletes with a history of ERLP and 24 training-matched control triathletes with no history of ERLP. Knee and ankle kinematics and leg muscle recruitment were compared between a baseline run (no prior exercise) and a transition run (preceded by cycling; i.e., run vs cycle run). RESULTS Knee and ankle joint kinematics were not different between baseline and transition runs for any triathletes: absolute mean difference (+/-95% confidence interval) was 1.49 degrees +/- 0.17 degrees. However, muscle recruitment was different between baseline and transition runs, defined by absolute mean difference in EMG amplitude > or = 10%, in 5 of 24 control triathletes (11/130 muscles exhibited altered recruitment) and in 5 of 10 triathletes with a history of ERLP (12/50 muscles exhibited altered recruitment). This represents a relative risk of 2.40 (0.89-6.50; P = 0.089) when defined by athletes and 2.62 (1.34-6.01; P < 0.01) when defined by muscles. The magnitude of change in muscle recruitment between baseline and transition runs was not different between control (14.10% +/- 2.34%) and ERLP triathletes (16.31% +/- 3.64%; P = 0.41). CONCLUSIONS This study demonstrates an association between ERLP in triathletes and their neuromuscular control when running off the bike.
Visual acuity loss in patients with age-related macular degeneration measured using a novel high-pass letter chart

Background/aims Conventional Logarithm of the Minimum Angle of Resolution (logMAR) acuity is the current gold standard for assessing visual function in age-related macular degeneration (AMD). However, visual acuity (VA) often remains ‘normal’ when measured with these charts, even with advanced retinal changes. We wished to investigate how VA measurements with the Moorfields Acuity Chart (MAC), which employs high-pass filtered letters, compares to conventional letter charts in subjects with AMD. Methods Monocular best-corrected VA measurements and test–retest variability (TRV) were compared for conventional and MAC charts in 38 normal observers (mean age 52.1 years) and 80 patients (mean age 80.6 years) with varying degrees of acuity loss owing to AMD. Methods of Bland–Altman and ordinary least-squares regression were employed for data analysis. Results A proportional bias was confirmed between conventional and MAC measurements (r2=0.133, p=0.001) such that MAC acuity was −0.45 logMAR ‘worse’ at the 0.00 logMAR acuity level, but only −0.26 logMAR ‘worse’ at the 1.00 logMAR level. The mean bias was much smaller in the normal subject group (−0.16 logMAR). Similar TRV (ranging from ±0.09 to ±0.12 logMAR) was found for both charts in both subject groups. Conclusions VA measurements with the MAC chart appear to be more sensitive to functional loss in AMD compared with conventional letter charts, with similar TRV. Simulations indicate this may be because the high-pass filtered letters are more vulnerable to undersampling as a result of retinal cell loss in the disease process.
Radiofrequency Ablation of Complex Fractionated Atrial Electrograms (CFAE): Preferential Sites of Acute Termination and Regularization in Paroxysmal and Persistent Atrial Fibrillation

Introduction: Complex fractionated atrial electrograms (CFAE) have been described as a new target for ablation of atrial fibrillation (AF). This prospective study evaluates the acute effects of CFAE ablation in patients with paroxysmal or persistent AF and analyzes the preferential anatomic sites where these effects occur.
Group work as an incentive for learning – students’ experiences of group work

Group work is used as a means for learning at all levels in educational systems. There is strong scientific support for the benefits of having students learning and working in groups. Nevertheless, studies about what occurs in groups during group work and which factors actually influence the students’ ability to learn is still lacking. Likewise, the question of why some group work is successful and other work results in the opposite is still unsolved. The aim of this article is to add to the current level of knowledge and understandings regarding the essence behind successful group work in higher education. This research is focused on the students’ experiences of group work and learning in groups, which is an almost non-existing aspect of research on group work prior to the beginning of the 21st century. A primary aim is to give university students a voice in the matter by elucidating the students’ positive and negative points of view and how the students assess learning when working in groups. Furthermore, the students’ explanations of why some group work ends up being a positive experience resulting in successful learning, while in other cases, the result is the reverse, are of interest. Data were collected through a study-specific questionnaire, with multiple choice and open-ended questions. The questionnaires were distributed to students in different study programs at two universities in Sweden. The present result is based on a reanalysis and qualitative analysis formed a key part of the study. The results indicate that most of the students’ experiences involved group work that facilitated learning, especially in the area of academic knowledge. Three important prerequisites (learning, study-social function and organization) for group work that served as an effective pedagogy and as an incentive for learning were identified and discussed. All three abstractions facilitate or hamper students’ learning, as well as impact their experiences with group work.
DEPARTMENT OF DECISION SCIENCES AND INFORMATION MANAGEMENT (KBI)

This paper studies the robust knapsack problem, for which solutions are, up to a certain point, immune to data uncertainty. We complement the works found in the literature where uncertainty affects only the profits or only the weights of the items by studying the complexity and approximation of the general setting with uncertainty regarding both the profits and the weights, for three different objective functions. Furthermore, we develop a scenario-relaxation algorithm for solving the general problem and present computational results.
The Relationship Among Spontaneity, Impulsivity, and Creativity

The present study was designed to investigate two characteristics of spontaneity, its relationship to creativity and to impulsivity. We hypothesized a positive relationship between spontaneity and creativity, consistent with Moreno, 1953 “canon of spontaneity-creativity. ” We also predicted a negative relationship between spontaneity and impulsivity. Participants were graduate and undergraduate students at an independent, urban university in Upper Midwest United States (N = 117) who were administered three inventories measuring spontaneity, impulsivity, and creativity. Results confirmed both predictions. Further, a different pattern of relationships existed between the four subscales measuring impulsivity and spontaneity and the four subscales measuring impulsivity, spontaneity, and creativity. The subscale measuring sensation seeking, however, showed a completely different pattern of relationship to creativity and impulsivity. It correlated positively with both.
Metabolic Activity of Radish Sprouts Derived Isothiocyanates in Drosophila melanogaster

We used Drosophila melanogaster as a model system to study the absorption, metabolism and potential health benefits of plant bioactives derived from radish sprouts (Raphanus sativus cv. Rambo), a Brassicaceae species rich in glucosinolates and other phytochemicals. Flies were subjected to a diet supplemented with lyophilized radish sprouts (10.6 g/L) for 10 days, containing high amounts of glucoraphenin and glucoraphasatin, which can be hydrolyzed by myrosinase to the isothiocyanates sulforaphene and raphasatin, respectively. We demonstrate that Drosophila melanogaster takes up and metabolizes isothiocyanates from radish sprouts through the detection of the metabolite sulforaphane-cysteine in fly homogenates. Moreover, we report a decrease in the glucose content of flies, an upregulation of spargel expression, the Drosophila homolog of the mammalian PPARγ-coactivator 1 α, as well as the inhibition of α-amylase and α-glucosidase in vitro. Overall, we show that the consumption of radish sprouts affects energy metabolism in Drosophila melanogaster which is reflected by lower glucose levels and an increased expression of spargel, a central player in mitochondrial biogenesis. These processes are often affected in chronic diseases associated with aging, including type II diabetes mellitus.
Having the Mind in the Cloud: Organizational Mindfulness and the Successful Use of Desktop as a Service

Increasingly, public organizations require higher levels of reliability and flexibility from information systems (IS) while trying to reduce costs at the same time. Cloud computing is a promising technology to fulfill these requirements. In particular, Desktop as a Service (DaaS), as one facet thereof, offers reliability and flexibility by means of consistent anytime anywhere access to applications and data. Being interested in success characteristics and benefits of DaaS use in governmental agencies, we applied organizational mindfulness (OM) as theoretical lens in our study. By mindfully using reliable IS, such as DaaS, significant negative consequences of errors in governmental agencies can be mitigated. Thus, informed by DeLone and McLean's IS Success Model we conducted a questionnaire-based study in a German State Ministry of Justice to analyze the differences between rather mindful and less mindful DaaS users and the resulting impact on task-related net benefits.
Cross-disciplinary engineering with AutomationML and SysML

Abstract AutomationML (AML) is an emerging standard in the automation domain to represent and exchange artifacts between heterogeneous engineering tools used in different disciplines, such as mechanical and electrical engineering. The Systems Modeling Language (SysML) is a modeling standard influenced by software modeling languages, such as UML, typically adopted in the early phases of engineering processes. This paper investigates commonalities and differences of the structural modeling parts of AML (CAEX) and SysML (block diagrams) in support of establishing tool-independent interoperability. This support for cross-disciplinary modeling is facilitated by a bridge between AML and SysML built on model-driven interoperability techniques. We demonstrate the interoperability between AML and SysML with a case study concerning a lab-sized production system.