Miracle-dz/UniFAR-FTUs huggingface dataset:
MIMD synchronization on SIMT architectures

In the single-instruction multiple-threads (SIMT) execution model, small groups of scalar threads operate in lockstep. Within each group, current SIMT hardware implementations serialize the execution of threads that follow different paths, and to ensure efficiency, revert to lockstep execution as soon as possible. These constraints must be considered when adapting algorithms that employ synchronization. A deadlock-free program on a multiple-instruction multiple-data (MIMD) architecture may deadlock on a SIMT machine. To avoid this, programmers need to restructure control flow with SIMT scheduling constraints in mind. This requires programmers to be familiar with the underlying SIMT hardware. In this paper, we propose a static analysis technique that detects SIMT deadlocks by inspecting the application control flow graph (CFG). We further propose a CFG transformation that avoids SIMT deadlocks when synchronization is local to a function. Both the analysis and the transformation algorithms are implemented as LLVM compiler passes. Finally, we propose an adaptive hardware reconvergence mechanism that supports MIMD synchronization without changing the application CFG, but which can leverage our compiler analysis to gain efficiency. The static detection has a false detection rate of only 4%-5%. The automated transformation has an average performance overhead of 8.2%-10.9% compared to manual transformation. Our hardware approach performs on par with the compiler transformation, however, it avoids synchronization scope limitations, static instruction and register overheads, and debuggability challenges that are present in the compiler only solution.
Vitamin K antagonist use and mortality in dialysis patients

Background The risk-benefit ratio of vitamin K antagonists for different CHA2DS2-VASc scores in patients with end-stage renal disease treated with dialysis is unknown. The aim of this study was to investigate the association between vitamin K antagonist use and mortality for different CHA2DS2-VASc scores in a cohort of end-stage renal disease patients receiving dialysis treatment. Methods We prospectively followed 1718 incident dialysis patients. Hazard ratios were calculated for all-cause and cause-specific (stroke, bleeding, cardiovascular and other) mortality associated with vitamin K antagonist use. Results Vitamin K antagonist use as compared with no vitamin K antagonist use was associated with a 1.2-fold [95% confidence interval (95% CI) 1.0-1.5] increased all-cause mortality risk, a 1.5-fold (95% CI 0.6-4.0) increased stroke mortality risk, a 1.3-fold (95% CI 0.4-4.2) increased bleeding mortality risk, a 1.2-fold (95% CI 0.9-1.8) increased cardiovascular mortality risk and a 1.2-fold (95% CI 0.8-1.6) increased other mortality risk after adjustment. Within patients with a CHA2DS2-VASc score ≤1, vitamin K antagonist use was associated with a 2.8-fold (95% CI 1.0-7.8) increased all-cause mortality risk as compared with no vitamin K antagonist use, while vitamin K antagonist use within patients with a CHA2DS2-VASc score ≥2 was not associated with an increased mortality risk after adjustment. Conclusion Vitamin K antagonist use was not associated with a protective effect on mortality in the different CHA2DS2-VASc scores in dialysis patients. The lack of knowledge on the indication for vitamin K antagonist use could lead to confounding by indication.
Interference Between Cognition, Double-Limb Support, and Swing During Gait in Community-Dwelling Individuals Poststroke

Background. Dual tasking can interfere with activity after stroke. Objective. The authors examined the interactions between 3 different cognitive tasks and the swing and double-limb support (DLS) components of the gait cycle in community-dwelling individuals poststroke. Methods. Acquisition of cognitive and gait data were synchronized to study the cognitive—motor interference effects during the different phases of the gait cycle. Participants performed 3 different cognitive tasks in isolation and in combination with walking as well as a single walking task. Tasks were performed continuously for 3 minutes, generating 131 ± 39 gait cycles per person for analysis for each walking trial. Data were analyzed for 8 participants 7.6 ± 4.2 months poststroke. Results. A significant increase was found in the proportion of the gait cycle spent in DLS in dual-task walking because of an increased duration of the DLS phase associated with paretic weight acceptance. There was a significant dual-task effect on nonparetic swing duration: participants reduced the amount of time in paretic single-limb stance in the 3 dual-task conditions. Temporal asymmetry of gait did not increase significantly under dual-task conditions. Reaction times were not affected by whether the stimuli were present during the swing or DLS phase of the gait cycle. Conclusions. The findings from this pilot study provide evidence that cognitive—motor interference during gait may be influenced by the phase of the gait cycle, especially DLS involving paretic weight acceptance, which may affect community ambulators with hemiparetic stroke.
Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Purpose: The oncogenic miR-155 is upregulated in many human cancers, and its expression is increased in more aggressive and therapy-resistant tumors, but the molecular mechanisms underlying miR-155-induced therapy resistance are not fully understood. The main objectives of this study were to determine the role of miR-155 in resistance to chemotherapy and to evaluate anti-miR-155 treatment to chemosensitize tumors. Experimental Design: We performed in vitro studies on cell lines to investigate the role of miR-155 in therapy resistance. To assess the effects of miR-155 inhibition on chemoresistance, we used an in vivo orthotopic lung cancer model of athymic nude mice, which we treated with anti-miR-155 alone or in combination with chemotherapy. To analyze the association of miR-155 expression and the combination of miR-155 and TP53 expression with cancer survival, we studied 956 patients with lung cancer, chronic lymphocytic leukemia, and acute lymphoblastic leukemia. Results: We demonstrate that miR-155 induces resistance to multiple chemotherapeutic agents in vitro, and that downregulation of miR-155 successfully resensitizes tumors to chemotherapy in vivo. We show that anti-miR-155-DOPC can be considered non-toxic in vivo. We further demonstrate that miR-155 and TP53 are linked in a negative feedback mechanism and that a combination of high expression of miR-155 and low expression of TP53 is significantly associated with shorter survival in lung cancer. Conclusions: Our findings support the existence of an miR-155/TP53 feedback loop, which is involved in resistance to chemotherapy and which can be specifically targeted to overcome drug resistance, an important cause of cancer-related death. Clin Cancer Res; 23(11); 2891–904. ©2016 AACR.
Flower-level developmental plasticity to nutrient availability in Datura stramonium: implications for the mating system

Background and Aims Studies of phenotypic plasticity in plants have mainly focused on (1) the effect of environmental variation on whole-plant traits related to the number of modules rather than on (2) the phenotypic consequences of environmental variation in traits of individual modules. Since environmental and developmental factors can produce changes in traits related to the mating system, this study used the second approach to investigate whether within-individual variation in herkogamy-related traits is affected by the environment during plant development in two populations of Datura stramonium , an annual herb with a hypothesized persistent mixed mating system, and to determine which morphological traits may promote self-fertilization. Methods Full-sib families of two Mexican populations of D. stramonium , with contrasting ecological histories, were grown under low, mid and high nutrient availability to investigate the effects of genetic, environmental and within-plant flower position on flower size, corolla, stamen and pistil lengths, and herkogamy. Key Results Populations showed differences in familial variation, plasticity and familial differences in plasticity in most floral traits analysed. In one population (Ticumán), the effect of flower position on trait variation varied among families, whereas in the other (Pedregal) the effect of flower position interacted with the nutrient environment. Flower size varied with the position of flowers, but in the opposite direction between populations in low nutrients; a systematic within-plant trend of reduction in flower size, pistil length and herkogamy with flower position increased the probability of self-fertilization in the Pedregal population. Conclusions Besides genetic variation in floral traits between and within populations, environmental variation affects phenotypic floral trait values at the whole-plant level, as well as among flower positions. The interaction between flower position and nutrient environment can affect the plant's mating system, and this differs between populations. Thus, reductions in herkogamy with flower positions may be expected in environments with either low pollinator abundance or low nutrients.
Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy.

BACKGROUND Human immunodeficiency virus (HIV)-infected patients are at increased risk of cardiovascular disease, which may be related to chronic inflammation and endothelial dysfunction despite virological control with antiretroviral therapy. The relationship between carotid intima-media thickness (IMT), a surrogate marker for cardiovascular disease, proinflammatory cytokines, and endothelial activation markers has not been fully explored in HIV-infected patients who are receiving antiretroviral therapy. METHODS We conducted a prospective, cross-sectional, observational study of treated HIV-infected patients and healthy control subjects to evaluate the relationship between carotid IMT, proinflammatory cytokines, endothelial activation biomarkers, and metabolic parameters in treated HIV-infected patients, compared with healthy control subjects. RESULTS We enrolled 73 HIV-infected patients and 21 control subjects. Common carotid artery and internal carotid artery IMT measurements, as well as tumor necrosis factor-alpha, high-sensitivity C-reactive protein, interleukin-6, myeloperoxidase, and soluble vascular cell adhesion molecule-1 levels were higher in the HIV-infected group. High-sensitivity C-reactive protein was the only biomarker that was positively correlated with carotid IMT in both groups. In the HIV-infected group, soluble vascular cell adhesion molecule-1 was positively correlated with all inflammatory cytokine levels. In multiple regression analysis, soluble vascular cell adhesion molecule-1, myeloperoxidase, and tumor necrosis factor-alpha levels were all associated with internal carotid artery IMT in the HIV-infected group, whereas age was associated with both common carotid artery and internal carotid artery IMT. CONCLUSIONS Enhanced endothelial activation, inflammation, and increased carotid IMT occur in HIV-infected patients despite antiretroviral therapy. Inflammatory markers are associated with endothelial activation, and both are associated with internal carotid artery IMT, supporting a potential role of inflammation in endothelial activation and cardiovascular disease in HIV infection.
Early assessment of the 10-step patient engagement framework for patient-centred outcomes research studies: the first three steps

Background A key principle of patient-centred outcomes research (PCOR) is the engagement of patients and other stakeholders in the research process, but the evidence is still emerging on the impact patient engagement has on the research process. A 10-step framework has been developed to provide methodological guidance for patient engagement throughout the research process. However, the utility of the framework for patient engagement has not been tested in actual research studies. Objective To describe researcher's overall experiences with engaging patients at the beginning of their PCOR research process. Methods Twelve in-depth interviews were conducted face-to-face and by telephone with PCOR researchers between November 2014 and January 2015 at an Academic Health Center in the eastern USA. All data were audiotaped and transcribed, and NVivo 10 software was used for data analysis. Results Four major themes emerged (i) the importance of patient engagement and how it provides 'a perspective you can't get unless you talk to the patient'; (ii) the impact of patient engagement; (iii) challenges and barriers of engagement; and (iv) the realities of patient engagement. Conclusions Researchers' views illustrate the need to re-evaluate patient engagement in PCOR based on current realities. Given the many challenges to engagement that researchers encounter, it may be more productive to redefine the process of patient engagement so that the issues researchers now face are taken into account in future funding announcements, engagement rubrics and methodology frameworks developed.
Evaluation of soil conditions using spectral indices from hyperspectral datasets

Soil condition monitoring is critical job by existing chemical treatments which is essential for crop growth for food production in efficient way. As well as soil is spatially and temporally vary everywhere. In the current scenario, hyperspectral remote sensing datasets are widely used by the researchers which provide the minute details of the earth surface objects especially soils. In that constraint, current study focuses the soil condition evaluation using various narrow band spectral indices derived by the hyperspectral imaging and non-imaging datasets. The Analytical Spectral Device (ASD) Field Spec 4 Spectroradiometer instrument was used for receiving the soil reflectance spectra as a non-imaging data source along with Earth Observing-1 (EO-1) satellite Hyperion sensor imaging data. Phulambri Taluka of Aurangabad district of Maharashtra, India was the tested site of present study. Five narrow band spectral indices were used such as Normalized Soil Moisture Index (NSMI), Normalized Difference Soil Index (NDSI), Desertification Soil Index (DSI), Soil Adjusted Vegetation Index (SAVI) and Normalized Difference Vegetation Index (NDVI) to evaluate the soil condition. The experimental results indicate that, the moisture was less in soil with 0.12 maximum values. The NDSI index was previously used on multispectral datasets where green and short wave bands were fully utilized. In the present study, NDSI index was fist time tested on green band 560nm with two short wave bands 1650nm and 2220nm, where short wave band 1650nm was resulted well rather than 2220nm short wave band. The DSI resulted most of the regions with minimum values, hence the soil was not deserted. SAVI and NDVI resulted very well for both the datasets. The study is beneficial in agricultural planning and management in cost effective and rapid way to evaluate the soil condition.
Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes*

Polycystin complexes, or TRPP-PKD complexes, made of transient receptor potential channel polycystin (TRPP) and polycystic kidney disease (PKD) proteins, play key roles in coupling extracellular stimuli with intracellular Ca2+ signals. For example, the TRPP2-PKD1 complex has a crucial function in renal physiology, with mutations in either protein causing autosomal dominant polycystic kidney disease. In contrast, the TRPP3-PKD1L3 complex responds to low pH and was proposed to be a sour taste receptor candidate. It has been shown previously that the protein partners interact via association of the C-terminal or transmembrane segments, with consequences for the assembly, surface expression, and function of the polycystin complexes. However, the roles of extracellular components, especially the loops that connect the transmembrane segments, in the assembly and function of the polycystin complex are largely unknown. Here, with an immunoprecipitation method, we found that extracellular loops between the first and second transmembrane segments of TRPP2 and TRPP3 associate with the extracellular loops between the sixth and seventh transmembrane segments of PKD1 and PKD1L3, respectively. Immunofluorescence and electrophysiology data further confirm that the associations between these loops are essential for the trafficking and function of the complexes. Interestingly, most of the extracellular loops are also found to be involved in homomeric assembly. Furthermore, autosomal dominant polycystic kidney disease-associated TRPP2 mutant T448K significantly weakened TRPP2 homomeric assembly but had no obvious effect on TRPP2-PKD1 heteromeric assembly. Our results demonstrate a crucial role of these functionally underexplored extracellular loops in the assembly and function of the polycystin complexes.
The Role of Interaction Patterns with Hybrid Electric Vehicle Eco-Features for Drivers’ Eco-Driving Performance

Objective: The objective of the present research was to understand drivers’ interaction patterns with hybrid electric vehicles’ (HEV) eco-features (electric propulsion, regenerative braking, neutral mode) and their relationship to fuel efficiency and driver characteristics (technical system knowledge, eco-driving motivation). Background: Eco-driving (driving behaviors performed to achieve higher fuel efficiency) has the potential to reduce CO2 emissions caused by road vehicles. Eco-driving in HEVs is particularly challenging due to the systems’ dynamic energy flows. As a result, drivers are likely to show diverse eco-driving behaviors, depending on factors like knowledge and motivation. The eco-features represent an interface for the control of the systems’ energy flows. Method: A sample of 121 HEV drivers who had constantly logged their fuel consumption prior to the study participated in an online questionnaire. Results: Drivers’ interaction patterns with the eco-features were related to fuel efficiency. A common factor was identified in an exploratory factor analysis, characterizing the intensity of actively dealing with electric energy, which was also related to fuel efficiency. Driver characteristics were not related to this factor, yet they were significant predictors of fuel efficiency. Conclusion: From the perspective of user–energy interaction, the relationship of the aggregated factor to fuel efficiency emphasizes the central role of drivers’ perception of and interaction with energy conversions in determining HEV eco-driving success. Application: To arrive at an in-depth understanding of drivers’ eco-driving behaviors that can guide interface design, authors of future research should be concerned with the psychological processes that underlie drivers’ interaction patterns with eco-features.
Dimensional assessment of DSM-5 social anxiety symptoms among university students and its relationship with functional impairment

Social anxiety disorder is a common condition often associated with severe impairment in educational career. The aim of this paper was to evaluate prevalence rates and correlates of mild, moderate, and severe forms of social anxiety spectrum in a large sample of university students. Overall, 717 university students were assessed with the Social Anxiety Spectrum Self-Report questionnaire. Using two cut-off scores, 61.4% of subjects were classified as low scorers, 10% as medium scorers, and 28.6% as high scorers. Both high and medium scorers reported fears related to social situations. Interpersonal sensitivity and specific phobias were more common among women with low scores. Childhood/adolescence social anxiety features were more common among males with medium scores. Behavioral inhibition was more common among males with high scores. Functional impairment was severe among high scorers and, to a lesser extent, among medium scorers. Social anxiety spectrum is largely represented among university students. Future studies should investigate whether sufferers of social phobia underachieve or end their professional objectives prematurely.
Vitamin D Deficiency in Pregnant Women and Their Infants

Objective: Vitamin D deficiency is a serious health problem despite a general improvement in socio-economic status in Turkey. The aim of this study was to evaluate maternal vitamin D status and its effect on neonatal vitamin D concentrations after a support programme for pregnant women was introduced. A second aim was to identify risk factors for vitamin D deficiency in a district of İstanbul. Methods: A total of 97 pregnant women and 90 infants were included in this study, conducted between January and October 2016. The demographic data, risk factors and daily vitamin intake were recorded. Serum levels of vitamin D, calcium, phosphorus and alkaline phosphatase in all subjects were measured. The mothers and newborns were divided into groups based on their vitamin D levels. The relationship between vitamin D levels and risk factors was analyzed. Results: Mean ± standard deviation vitamin D levels for the women and their infants were found to be 14.82±11.45 and 13.16±7.16 ng/mL, respectively. The number of mothers and infants was significantly higher in the deficient group, and their mean vitamin D levels significantly lower (9.02±1.34 and 8.80±1.06 ng/mL, respectively) (p<0.001, p<0.001). Only 14.4% of pregnant women took 1000-1200 IU/day of vitamin D. When the mother groups were evaluated in terms of risk factors, there were significant differences in daily vitamin intake and clothing style (p<0.001 and p<0.001 respectively). Conclusion: Vitamin D deficiency in pregnant women and their infants is still a serious health problem in Turkey, although a vitamin D support programme during pregnancy has been launched by the department of health.
Some test results for wrinkling of girth-welded line pipe

The paper describes a series of tests on specimens of full size line pipe subjected to constant axial force, constant internal pressure, and monotonically increasing curvatures. Two sizes of pipe, representative of those used in pipelines for transmission of hydrocarbons, were tested. The test specimens all had girth welds at mid-length and the bending curvatures were continued until wrinkles of large amplitude had formed. Measurements Of rotations, displacements, and strains were recorded during the tests. All pressurized specimens developed bulging Wrinkles while unpressurized specimens developed diamond pattern wrinkles. All specimens entered a softening range when the wrinkling deformations became evident. The characteristics of the moment-curvature relationships are studied and the strains at which wrinkling initiates are evaluated for these pipe specimens. Comparisons with previous test results on plain pipe permit the effect of the girth weld on the strains at initiation of wrinkling to be determined.