Miracle-dz/UniFAR-FTUs huggingface dataset:
Co-Located Collaborative Visual Analytics around a Tabletop Display

Co-located collaboration can be extremely valuable during complex visual analytics tasks. We present an exploratory study of a system designed to support collaborative visual analysis tasks on a digital tabletop display. Fifteen participant pairs employed Cambiera, a visual analytics system, to solve a problem involving 240 digital documents. Our analysis, supported by observations, system logs, questionnaires, and interview data, explores how pairs approached the problem around the table. We contribute a unique, rich understanding of how users worked together around the table and identify eight types of collaboration styles that can be used to identify how closely people work together while problem solving. We show how the closeness of teams' collaboration and communication influenced how they performed on the task overall. We further discuss the role of the tabletop for visual analytics tasks and derive design implications for future co-located collaborative tabletop problem solving systems.
Process mining with the HeuristicsMiner algorithm

The basic idea of process mining is to extract knowledge from event logs recorded by an information system. Until recently, the information in these event logs was rarely used to analyze the underlying processes. Process mining aims at improving this by providing techniques and tools for discovering process, organizational, social, and performance information from event logs. Fuelled by the omnipresence of event logs in transactional information systems (cf. WFM, ERP, CRM, SCM, and B2B systems), process mining has become a vivid research area [1, 2]. In this paper we introduce the challenging process mining domain and discuss a heuristics driven process mining algorithm; the so-called “HeuristicsMiner” in detail. HeuristicsMiner is a practical applicable mining algorithm that can deal with noise, and can be used to express the main behavior (i.e. not all details and exceptions) registered in an event log. In the experimental section of this paper we introduce benchmark material (12.000 different event logs) and measurements by which the performance of process mining algorithms can be measured.
The Infinite Tree

Historically, unsupervised learning techniques have lacked a principled technique for selecting the number of unseen components. Research into non-parametric priors, such as the Dirichlet process, has enabled instead the use of infinite models, in which the number of hidden categories is not fixed, but can grow with the amount of training data. Here we develop the infinite tree, a new infinite model capable of representing recursive branching structure over an arbitrarily large set of hidden categories. Specifically, we develop three infinite tree models, each of which enforces different independence assumptions, and for each model we define a simple direct assignmentsampling inference procedure. We demonstrate the utility of our models by doing unsupervised learning of part-of-speech tags from treebank dependency skeleton structure, achieving an accuracy of 75.34%, and by doing unsupervised splitting of part-of-speech tags, which increases the accuracy of a generative dependency parser from 85.11% to 87.35%.
Motoric Cognitive Risk Syndrome Subtypes and Cognitive Profiles.

BACKGROUND The motoric cognitive risk (MCR) syndrome, characterized by slow gait and cognitive complaints, is a simple and easily accessible clinical approach to identify older adults at high risk for transitioning to dementia. This study aims to define subtypes of MCR based on individual quantitative gait variables and to compare their neuropsychological profiles and risk factors as well risk for incident cognitive impairment. METHODS MCR was diagnosed in 314 community-residing, nondemented, older adults aged 65 and older (56% women) based on the presence of cognitive complaints and slow gait velocity (MCRv). Four new subtypes of MCR were defined by substituting slow gait with short stride length (MCRsl), slow swing time (MCRsw), high stride length variability (MCRslv), and high swing time variability (MCRswv). MCR subtypes were not mutually exclusive. RESULTS A total of 25 participants (8%) met criteria for MCRv, 20 for MCRsl (6.4%), 15 for MCRsw (4.8%), 16 for MCRslv (5.1%), 12 for MCRswv (3.8%), and 266 participants (84.7%) did not meet criteria for any MCR subtype. At baseline, MCRv was associated with deficits in attention and language as well as in overall cognitive status. MCRswv was associated with deficits in all cognitive domains including memory. Obesity and sedentariness were risk factors of MCRv, MCRsl, and MCRsw. MCRv status predicted incident cognitive impairment in global cognition (odds ratio: 3.59, p = .016), whereas MCRswv status predicted incident cognitive impairment in memory (odds ratio: 4.24, p = .048). CONCLUSIONS MCR subtypes based on individual gait parameters show commonalities and differences in cognitive profiles and risk factors. Future studies should investigate whether the MCR subtypes predict different subtypes of dementia.
Natural and anthropogenic influences recorded in sediments from the Krka river estuary (Eastern Adriatic coast), evaluated by statistical methods

Surface sediments and cores from the Krka river estuary (Eastern Adriatic coast) were analyzed for their trace-element composition by means of HR ICP-MS (High Resolution Inductively Coupled Plasma Mass Spectrometry). Various statistical analyses were used to evaluate the geochemical composition of these sediments and to establish the degree of anthropogenic influence to the Krka river estuary. Statistical analysis showed clear anthropogenic influence on several spots of the Krka river estuary. Sediments sampled in the Sibenik port demonstrated the highest concentrations of ecotoxic metals as being Cd (34.4 mg/kg), Zn (4010 mg/kg), Pb (253 mg/kg), As (45.3 mg/kg) and Cu (24.6 mg/kg). Calculated Muller’ s geoaccumulation index (Igeo) values, after normalization on average carbonate values are for Cd (4.7), Zn (6.9), Pb (4.2), As (5.5), Cu (2.0). Igeo values after normalization on average shale are for Cd (6.3), Zn (4.9), Pb (3.1), As (1.6), Cu (1.6). It suggests moderately to heavily polluted Sibenik harbor. The pollution source at this location results from long-term phosphate ore unloaded at the port as well as input of untreated wastewaters from the city of Sibenik. Another contaminated area was established in front of the now closed ferromanganese factory, with maximum measured concentrations of Mn (2526 mg/kg), Pb (143 mg/kg) and Ba (255 mg/kg). However, in the major portions of the Krka river estuary concentrations of measured elements were low and varied only due to natural (lithogenic and marine) influences. This indicates that the majority portions of the Krka river estuary is still unpolluted.
Risk of Hip Fractures in Men with Alpha-Blockers: A Nationwide Study Base on Claim Registry

Background Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database. Methods We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR). Results Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker. Conclusions Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
GDE3: the third evolution step of generalized differential evolution

A developed version of generalized differential evolution, GDE3, is proposed. GDE3 is an extension of differential evolution (DE) for global optimization with an arbitrary number of objectives and constraints. In the case of a problem with a single objective and without constraints GDE3 falls back to the original DE. GDE3 improves earlier GDE versions in the case of multi-objective problems by giving a better distributed solution. Performance of GDE3 is demonstrated with a set of test problems and the results are compared with other methods
Patients with heart attacks are not valid models for medial temporal lobe amnesia. A neuropsychological and FDG‐PET study with consequences for memory research

Equating the condition after cardiac arrest with that of medial temporal damage, and consequently medial temporal lobe amnesia, is questioned on the basis of results from a patient who was studied neuropsychologically as well as with static and dynamic imaging methods (MRI, PET) 6–9 months after a heart attack. The patient manifested severe and persistent anterograde and retrograde amnesia, as well as further cognitive deteriorations. While MRI only indicated non‐specific cortical atrophy, PET revealed a severe bilateral affection of the thalamus and of both medial and lateral temporal cortices as well as occipito‐parietal hypometabolism. The neuropsychological status indicates that patients with a diagnosis of cardiac arrest may suffer very severe and persistent cognitive deficits; the imaging analyses show that cardiac arrests may lead to quite severe and widespread brain damage which, however, may not be visible with current magnetic resonance imaging technology, but which is clearly apparent from positron emission tomography. These data suggest that patients with a condition after a heart attack may not be valid models for pure hippocampal—or even medial temporal lobe—pathology, as they may suffer much more widespread brain damage.
Evolution of Gender Differences in Post‐Secondary Human Capital Investments: College Majors

Although women in the United States now complete more college degrees than men, the distribution of college majors among college graduates remains unequal, with women about two‐thirds as likely as men to major in business or science. We develop and estimate a dynamic, overlapping generations model of human capital investments and labor supply. We allow for specific college major choices, instead of aggregating these choices to the education level. Results show that changes in skill prices, higher schooling costs, and gender‐specific changes in home value were each important to the long‐term trends.
MiRNAs in β-Cell Development, Identity, and Disease

Pancreatic β-cells regulate glucose metabolism by secreting insulin, which in turn stimulates the utilization or storage of the sugar by peripheral tissues. Insulin insufficiency and a prolonged period of insulin resistance are usually the core components of type 2 diabetes (T2D). Although, decreased insulin levels in T2D have long been attributed to a decrease in β-cell function and/or mass, this model has recently been refined with the recognition that a loss of β-cell “identity” and dedifferentiation also contribute to the decline in insulin production. MicroRNAs (miRNAs) are key regulatory molecules that display tissue-specific expression patterns and maintain the differentiated state of somatic cells. During the past few years, great strides have been made in understanding how miRNA circuits impact β-cell identity. Here, we review current knowledge on the role of miRNAs in regulating the acquisition of the β-cell fate during development and in maintaining mature β-cell identity and function during stress situations such as obesity, pregnancy, aging, or diabetes. We also discuss how miRNA function could be harnessed to improve our ability to generate β-cells for replacement therapy for T2D.
Kinematic strategies for upper arm-forearm coordination in three dimensions.

This study addressed the question of how the three-dimensional (3-D) control strategy for the upper arm depends on what the forearm is doing. Subjects were instructed to point a laser-attached in line with the upper arm-toward various visual targets, such that two-dimensional (2-D) pointing directions of the upper arm were held constant across different tasks. For each such task, subjects maintained one of several static upper arm-forearm configurations, i. e. , each with a set elbow angle and forearm orientation. Upper arm, forearm, and eye orientations were measured with the use of 3-D search coils. The results confirmed that Donders' law (a behavioral restriction of 3-D orientation vectors to a 2-D "surface") does not hold across all pointing tasks, i.e., for a given pointing target, upper arm torsion varied widely. However, for any one static elbow configuration, torsional variance was considerably reduced and was independent of previous arm position, resulting in a thin, Donders-like surface of orientation vectors. More importantly, the shape of this surface (which describes upper arm torsion as a function of its 2-D pointing direction) depended on both elbow angle and forearm orientation. For pointing with the arm fully extended or with the elbow flexed in the horizontal plane, a Listing's-law-like strategy was observed, minimizing shoulder rotations to and from center at the cost of position-dependent tilts in the forearm. In contrast, when the arm was bent in the vertical plane, the surface of best fit showed a Fick-like twist that increased continuously as a function of static elbow flexion, thereby reducing position-dependent tilts of the forearm with respect to gravity. In each case, the torsional variance from these surfaces remained constant, suggesting that Donders' law was obeyed equally well for each task condition. Further experiments established that these kinematic rules were independent of gaze direction and eye orientation, suggesting that Donders' law of the arm does not coordinate with Listing's law for the eye. These results revive the idea that Donders' law is an important governing principle for the control of arm movements but also suggest that its various forms may only be limited manifestations of a more general set of context-dependent kinematic rules. We propose that these rules are implemented by neural velocity commands arising as a function of initial arm orientation and desired pointing direction, calculated such that the torsional orientation of the upper arm is implicitly coordinated with desired forearm posture.
Analgesic efficacy of pre‐operative stellate ganglion block on postoperative pain relief: a randomised controlled trial

We undertook a randomised, double‐blind, placebo‐controlled study to compare the analgesic efficacy of pre‐operative stellate ganglion block on postoperative pain relief after upper limb orthopaedic surgery. Patients were administered a 3‐ml injection during ultrasound‐guided stellate ganglion block; 15 patients received lidocaine 2% and 15 patients received 0.9% saline. Following the block, all patients received standardised general anaesthesia. Postoperative analgesia included regular intravenous diclofenac, paracetamol and patient‐controlled analgesia with tramadol for 24 h. Patients were observed at 0, 2, 4, 6, 8, 12 and 24 h after surgery for tramadol consumption, cardiovascular variables and visual analogue scale pain scores at rest and on movement. The mean (SD) hourly tramadol consumption was significantly reduced in the lidocaine group compared with the saline group at 4 h (8.0 (10.1) mg vs 28.0 (12.6) mg, respectively; p = 0.001), 6 h (5.3 (10.8) mg vs 17.3 (12.7) mg, respectively; p = 0.013) and 8 h (5.3 (11.8) mg vs 21.3 (9.1) mg, respectively; p = 0.001). The cumulative 24‐h tramadol consumption was 97.3 (16.6) mg in the lidocaine group and 150.6 (26.0) mg in the saline group (p = 0.001). There were significant differences in the pain visual analogue scale at rest at two time points; at 4 h the median (IQR [range]) visual analogue scale scores were 4 (4–6 [2–8]) in the lidocaine group and 5 (4–6 [2–7]) in the saline group (p = 0.03), and at 6 h visual analogue scale scores were 3 (3–4 [3–6]) and 4 (4–6 [2–7]), respectively (p = 0.04). Pain visual analogue scale on movement was lower in the lidocaine group at all time intervals compared with the saline group, but this did not reach statistical significance. The present study has demonstrated a postoperative tramadol‐sparing and analgesic effect of pre‐operative stellate ganglion block in patients undergoing upper limb orthopaedic surgery under general anaesthesia.
Digital Service Flexibility and Performance of Credit Unions

Despite growth of information technology (IT) enabled services, how IT provides flexibility in service rendering and delivery, remains a relatively unexplored area of research. In this study, we investigate how digital service flexibility (DSF) influences performance of credit unions – an exemplary set of service oriented firms. We identify three dimensions of digital service flexibility: (1) basic digital service flexibility (basic DSF), (2) customer-oriented digital service flexibility (customer DSF), and (2) transaction-oriented digital service flexibility (transaction DSF). We argue that transaction DSF complements the basic DSF in influencing the performance, whereas customer DSF has a negative moderation effect on basic DSF and performance relationship. Using an archival data set, we find empirical support for the hypothesized relationships; and discuss contributions and implications of the findings.
The ghosts of Gondwana and Laurasia in modern liverwort distributions

Recent advances in phylogenetics and, in particular, molecular dating, indicate that transoceanic dispersal has played an important role in shaping plant and animal distributions, obscuring any effect of tectonic history. Taxonomic sampling in biogeographic studies is, however, systematically biased towards vertebrates and higher plants and the possibility remains that a much stronger signature of ancient vicariance might be evident among other organisms, particularly among basal land plants. Here, an explicit Bayesian model‐based approach was used to investigate global‐scale biogeographic patterns among liverwort genera and to determine whether the patterns identified are consistent with the expectations of vicariance or dispersal scenarios. The distribution of each genus was mapped onto the phylograms describing the floristic affinities among areas in order to define the synapomorphic transitions supporting the observed groupings. The probabilities of change in a branch were calculated by implementing the Markov model of BayesTraits. The consistent ambiguity in ancestral state reconstructions returned by the unconstrained, two‐rate model indicated that the overall signal in the data was weak, leading us to test the performance of competing, explicit models. The analyses resolved clades of geographic areas that are mostly consistent with the kingdoms traditionally identified for plants and animals, but with strikingly lower rates of endemism. The major split observed in the phylograms is into almost entirely Laurasian and Gondwanan clades. Other patterns recovered by the analyses, including Wallace's line and the South Atlantic Disjunction, have also traditionally been interpreted in terms of vicariance. These observations contrast with the idea that, in spore‐dispersed organisms like bryophytes and pteridophytes, dispersal obscures evidence of vicariance. However, some discrepancies between the liverwort trees and expectations from a continental drift scenario were observed, such as the sister‐group relationship of the Australian and New Zealand floras, which is supported by the co‐occurrence of many genera, often endemic to these two areas. Together with an interpretation of the results within a phylogenetic context, our analyses suggest that patterns, which are at first sight consistent with an ancient vicariance hypothesis, may, in fact, conceal a complex mixture of relictual distributions and more recent, asymmetrical dispersal events. Our results provide a framework for testing specific evolutionary hypotheses concerning the extremely low levels of endemism in bryophytes and in particular, the significance of dispersal and cryptic diversification.
SIXTH INTERNATIONAL WORKSHOP ON TROPICAL CYCLONES Topic 2 . 2 : Internal influences on Tropical Cyclone formation Rapporteurs :

This report summarizes work completed since ITWC-V that contributes to an improved understanding of the internal influences on tropical cyclone (TC) formation. The report argues the importance of low-level vorticity enhancement during TC genesis due to convergence in convective regions, both on the individual convective element scale and on the system scale. It is argued that large-scale processes essentially drive TC genesis. These large-scale processes set up a favorable environment, and initiate the mesoscale intensification mechanisms that construct the TC-scale vortex. It is argued that these large-scale processes, and a significant portion of the mesoscale processes, are represented in contemporary global NWP models. However, the finer detail not resolved by these models is believed to be important for a more complete understanding of intrinsic upscale growth mechanisms that can occur in rotating moist convective systems and the TC genesis process in particular. This has been the subject of much research in the past four years.
Acute Traumatic Occupational Hand Injuries: Type, Location, and Severity

The National Electronic Injury Surveillance System reports that the fingers and hand are the most frequent body parts injured at work and treated in hospital emergency departments. In this study, we describe the type, location, and severity of occupational hand injuries among 1166 patients recruited from 23 occupational health clinics in five New England states. Subjects ranged in age from 18 to 77 years, with a mean of 37.2 years (SD, 11.4), and approximately 75% were men. In decreasing order of frequency, subjects were employed in machine trades, service work, structural work, and less frequently, in benchwork, professional, technical managerial and clerical, and sales work. The majority of subjects (83.4%) had a single type of injury: 62.6% were lacerations, 13.1% were crush injuries, 8.0% were avulsions, and 6.1% were punctures. Metal items, such as nails, metal stock, and burrs accounted for 38.4% of the injuries, followed by hand tools with blades and powered machinery (24.4% and 12.3%, respectively). Hand tools with blades were least likely to result in multiple types of injuries, whereas powered machines or nonpowered hand tools were more likely to result in multiple types of injuries than other injury sources. The generalizability of these results should be limited to clinic-based patients employed in similar occupations. The results of this study may suggest possible prevention strategies for acute traumatic hand injuries.
Experimental evolution of resistance to an antimicrobial peptide

A novel class of antibiotics based on the antimicrobial properties of immune peptides of multicellular organisms is attracting increasing interest as a major weapon against resistant microbes. It has been claimed that cationic antimicrobial peptides exploit fundamental features of the bacterial cell so that resistance is much less likely to evolve than in the case of conventional antibiotics. Population models of the evolutionary genetics of resistance have cast doubt on this claim. We document the experimental evolution of resistance to a cationic antimicrobial peptide through continued selection in the laboratory. In this selection experiment, 22/24 lineages of Escherichia coli and Pseudomonas fluorescens independently evolved heritable mechanisms of resistance to pexiganan, an analogue of magainin, when propagated in medium supplemented with this antimicrobial peptide for 600–700 generations.