Miracle-dz/UniFAR-FTUs huggingface dataset:
Galois representations attached to moments of Kloosterman sums and conjectures of Evans

Abstract Kloosterman sums for a finite field $\mathbb{F}_{p}$ arise as Frobenius trace functions of certain local systems defined over $\mathbb{G}_{m,\mathbb{F}_{p}}$. The moments of Kloosterman sums calculate the Frobenius traces on the cohomology of tensor powers (or symmetric powers, exterior powers, etc.) of these local systems. We show that when $p$ ranges over all primes, the moments of the corresponding Kloosterman sums for $\mathbb{F}_{p}$ arise as Frobenius traces on a continuous $\ell$-adic representation of $\text{Gal}(\overline{\mathbb{Q}}/\mathbb{Q})$ that comes from geometry. We also give bounds on the ramification of these Galois representations. All of this is done in the generality of Kloosterman sheaves attached to reductive groups introduced by Heinloth, Ngô and Yun [Ann. of Math. (2) 177 (2013), 241–310]. As an application, we give proofs of conjectures of Evans [Proc. Amer. Math. Soc. 138 (2010), 517–531; Israel J. Math. 175 (2010), 349–362] expressing the seventh and eighth symmetric power moments of the classical Kloosterman sum in terms of Fourier coefficients of explicit modular forms. The proof for the eighth symmetric power moment conjecture relies on the computation done in Appendix B by C. Vincent.
Improved care for diabetes in underserved populations.

UNLABELLED Diabetes mellitus (DM) is a common chronic health condition among the adult population in the United States. DM is more prevalent and complications higher in Latinos, possibly due to inadequate medical and self-care as well as inaccurate culture-bound beliefs. Project Dulce is a nurse-managed DM educational and treatment program designed to measure the effect on clinical outcomes, adherence to American Diabetes Association and American Heart Association standards of care, and cultural beliefs in 210 high risk (HbA1c > 9.5%) and 346 lower risk (HbA1c < 9.5%) indigent Latinos with DM. METHODS All patients were given a 12-week culturally sensitive educational program. Nurse manager/certified diabetes educators working together with primary care providers treated high-risk patients using protocols from Staged Diabetes Management. Physical exam and biochemical markers of DM were followed. Pre- and post-program questionnaires measured changes in diabetes knowledge, cultural beliefs practices, treatment satisfaction, and health locus of control. Chart reviews of Latinos with diabetes (n = 311) not enrolled in Project Dulce provided the case controls. RESULTS After 1 year, the high-risk group showed significant improvements in HbA1c (11.5% to 8.3%, p < 0.0001), total cholesterol (219 to 181 mg/dL, p < 0.00001), SBP (129 to 122 mmHg, p < 0.03), and DBP (79 to 75 mmHg, p < 0.006). Pre- and post-test evaluations showed improved diabetes knowledge (p = .024), treatment satisfaction (p = .001) and internal locus of control (p = 0.04), and fewer inaccurate culture-bound beliefs (p = 0.001). Compliance was 100% in the high-risk group in obtaining HbAlc, lipids, urine microalbumin, and foot exams and 47% in obtaining eye exams, while the case controls had 28%, 46%, 31%, 14%, and 6% respectively. Mean TC and LDL values improved in Project Dulce patients compared to case controls (181 vs 221 Img/dL, p < 0.0001 and 99 vs 1241 mg/dL, p < 0.0004). CONCLUSION Patients enrolled in Project Dulce had significantly improved clinical outcomes, adherence to standards of care, and culture bound beliefs. Nurse managed diabetes management programs that are culturally sensitive may decrease the incidence of complications of diabetes and improve health outcomes.
Correction of analytical results for recovery: a comparison of the method performance characteristics from recent collaborative trials studies for aflatoxin quantification using conventional and robust statistics

Results from recently conducted collaborative trials on the determination of aflatoxin B1 in various matrices have been evaluated to establish whether the use of recovery data would result in a distinct change of the relative between-laboratory standard deviation (RSDR) of the corrected data compared with the uncorrected data. In addition, we applied conventional and robust statistics to evaluate whether the impact of the use of recovery data on the estimation of RSDR depended on the statistical method applied for data analysis. This investigation was based on means before and after correction for recovery. The method performance characteristics were calculated using results from naturally contaminated test materials, while the results from test materials fortified with the target analytes were used to estimate the recovery. The study revealed that applying conventional and robust statistics in general led to comparable estimates for RSDR. The comparison about the use of recovery data showed that in most cases, the RSDR obtained from the analysis of aflatoxin B1 decreased after correction of the results for recovery. This tendency was similar when the comparison was done using robust or conventional statistics. However, in three cases, conventional statistics yielded a higher RSDR for the corrected data, whereas robust statistics showed the opposite. Looking carefully at the data, the treatment of conventional statistics indicated that the way outliers are detected and removed could result in an under- or overestimation of RSDR. Applying the law of error propagation revealed that most likely the correlation between the uncorrected data and the recovery rate led to a reduced variability of the data corrected for recovery.
Tannerella forsythia and Pseudomonas aeruginosa in subgingival bacterial samples from parous women.

BACKGROUND Information on the subgingival microbiota in parous women is limited. The present study assessed 74 bacterial species at periodontal sites. METHODS Subgingival bacterial plaque was collected from women > or =6 months after delivery. Bacteria were assessed by the checkerboard DNA-DNA hybridization method. Gingivitis was defined as > or =20% of sites with bleeding on probing (BOP), and periodontitis was defined as radiographic evidence of bone loss and probing depths > or =5.0 mm. RESULTS A total of 197 women (mean age: 29.4 +/- 6.8 years; range: 18 to 46 years) were included in the study. Gingivitis was identified in 82 of 138 subjects without evidence of periodontitis (59.4%). Periodontitis was found in 59 women (32%). Higher bacterial levels in subjects with gingivitis compared to those without evidence of gingivitis were observed for Actinomyces neuii, Bifidobacterium bifidum, Corynebacterium pseudogenitalis, Porphyromonas endodontalis, Prevotella bivia, and Pseudomonas aeruginosa (P <0.001 for each). Higher bacterial levels in subjects with periodontitis compared to those without periodontitis (BOP not accounted for) were found for 32 of 79 species (P <0.001) including Lactobacillus iners, Haemophilus influenzae, Porphyromonas gingivalis, Tannerella forsythia (previously T. forsythensis), Prevotella bivia, P. aeruginosa, and Staphylococcus aureus. Binary univariate logistic regression analysis identified that P. aeruginosa (P <0.001) and T. forsythia (P <0.05) were independently predictive of periodontal status. The odds ratio of having P. aeruginosa at levels > or =1 x 10(5) in the sample and periodontitis was 3.1 (95% confidence interval: 1.6 to 5.9; P <0.001). CONCLUSION In addition to P. gingivalis and T. forsythia, a diverse microbiota, including P. aeruginosa, P. endodontalis, P. bivia, and S. aureus, can be found in subgingival plaque samples from women of child-bearing age with periodontitis.
Certification Enhance Environmental Performance ? Conditions under which Environmental Performance Improvement Occurs

The empirical literature regarding the efficacy of ISO 14001 certification in improving facilities' environmental performance has treated ISO certification as a homogenous phenomenon, that is, there is no difference in the design, development and use of ISO 14001 standards among facilities. This does not hold in practice. Different facilities may have very different ISO 14001 practices, which must have an impact on the linkage between ISO certification and facilities' environmental performance. This study finds that facilities that developed EMSs in the process of ISO certification, that assimilated ISO standards into their daily operations to a larger extent and that included performance elements in their ISO 14001 standards to a larger extent are more likely to report a greater environmental performance improvement and more likely to report that ISO certification contributed to the improvement. This study suggests that the future ISO certification might consider including some performance management elements, and some measures to ensure that facilities assimilate ISO standards into their daily operations. It also suggests that special treatment, such as regulatory flexibility, for ISO certified facilities may be a desirable policy instrument as it could promote the adoption of an EMS by facilities without one, providing the environmental benefits associated with a well grounded EMS.
Airport Terminal Capacity Planning using Delay Time Approximations and Multistage Stochastic Programming

An important part of the airport terminal design process is the determination of the optimal design capacities for different areas of the terminal under the uncertainty of future demand levels and expansion costs. Due to the difficulty of this task, most studies in this area either do not account for expandability or focus only on one particular area of the terminal. Furthermore, modeling passenger flow under the transient demand patterns is usually difficult due to the complex structure of an airport terminal. In this study, we aim to remedy these shortcomings first by developing functions to approximate maximum delays in passageways and processing stations during peak periods. We then use these delay functions to propose a multistage stochastic programming approach based on a multicommodity flow network representation of the whole airport terminal. Solution of the proposed model provides optimal capacity requirements for each area in an airport terminal during the initial building phase, as well as the optimal expansion policy under stochastic future demand.
Effect of cardiac exposure by median sternotomy on atrial fibrillation cycle length.

BACKGROUND Epicardial mapping is a powerful tool that has enabled us to gain insight into the electrical phenomena perpetuating atrial fibrillation and has guided the design of surgical and catheter-based therapeutic strategies. However, epicardial data are acquired during abnormal physiological conditions; the patients are anaesthetized, their chests opened, dislocating the heart and exposing it to air of room temperature, and the autonomic tone is modulated due to the surgery. The effect of intra-operative conditions on atrial electrophysiological properties have not been investigated before. Thus in the present study we assessed the atrial cycle length, shown to be an index of atrial refractoriness, and the ventricular rate before and during open-heart surgery in 10 patients with chronic atrial fibrillation and an underlying heart disease. METHODS AND RESULTS Using a newly introduced and validated ECG method known as frequency analysis of fibrillatory ECG (FAF-ECG), the atrial cycle length and the ventricular rate were determined just before surgery. After anaesthesia and median sternotomy, epicardial mapping of the entire right atrial free wall was performed. The mean ventricular rate as well as the dominant atrial fibrillation cycle length consistently increased, the former from 71 to 92 beats x min(-1) (mean of all patients, P<0.05) and the latter from 156 to 172 ms (P<0.05). CONCLUSIONS Atrial fibrillation cycle length, an index of atrial refractoriness, is increased as an effect of anaesthesia and heart exposure during open-heart surgery in patients with chronic atrial fibrillation, implying that atrial activation might be altered, which must be considered when interpreting data from epicardial conduction analysis.
The Inhibitory Receptor PIR-B Negatively Regulates Neutrophil and Macrophage Integrin Signaling1

The Ig-like receptor family member, PIR-B, has been shown to play an inhibitory role in receptor signaling within B cells, mast cells, and dendritic cells. As it has been implicated in integrin-mediated responses, we investigated the effect of loss of the PIR-B protein on integrin-mediated signaling in primary murine myeloid cells. The pir-b−/− neutrophils displayed enhanced respiratory burst, secondary granule release, and a hyperadhesive phenotype when plated on surfaces coated with either extracellular matrix proteins or cellular adhesion molecules in the presence or absence of the soluble inflammatory agonist TNF-α. The pir-b−/− and wild-type cells responded equivalently when stimulated with TNF-α in suspension, indicating that the hyperresponsive phenotype of the pir-b−/− cells during adhesion was due to enhanced integrin signaling. Both wild-type and pir-b−/− neutrophils expressed similar levels of integrin subunits. Primary bone marrow-derived macrophages from pir-b−/− mice were also hyperadhesive and spread more rapidly than wild-type cells following plating on surfaces that cross-linked cellular β2 integrins. Biochemical analysis of macrophages from pir-b−/− mice revealed enhanced phosphorylation and activation of proteins involved in integrin signaling. These observations point to a nonredundant role for PIR-B in the regulation of leukocyte integrin signaling.
Suppression of vestibular nystagmus by forced convergence in normal human subjects.

BACKGROUND It has been suggested that the principal mechanism of nystagmus suppression in the nystagmus blockage syndrome is either adduction of the eye or convergence. We examined this issue using the nystagmus of the vestibulo-ocular reflex (VOR) as a model. METHODS A motorized, computer-controlled rotary chair was used to produce VOR in darkness, using either sinusoidal or velocity step stimulation. Left eye position was monitored and horizontal slow-phase eye velocity was calculated. Subjects were cued to converge or perform other gaze tasks. RESULTS Convergence suppressed nystagmus. With sinusoidal stimulation, nystagmus was nearly extinguished in extreme lateroversion, probably due to mechanical tethering of the eye. However, VOR gain suppression of 47% during convergence was observed even when the monitored eye was close to primary position. With velocity step stimulation, nystagmus was nearly extinguished at moderate angles of adduction. CONCLUSIONS Convergence is sufficient to suppress nystagmus, without vision and without regard to whether the eye is adducted.
Dynamic properties of SOD1 mutants can predict survival time of patients carrying familial amyotrophic lateral sclerosis

One of the reasons for the death of motor neurons of the brain and spinal cord in patients with amyotrophic lateral sclerosis is known to be formation of subcellular protein aggregates that are caused by mutations in the SOD1 gene. Patient survival time was earlier shown to have limiting correlation with thermostability change of SOD1 mutant forms of patients’ carriers. We hypothesized that aggregation of mutant SOD1 may occur not only due to the protein destabilization, but through formation of novel interatomic bonds which stabilize “pathogenic” conformations of the mutant as well. To estimate these effects in the present paper, we performed statistical analysis of occupancy of intramolecular hydrogen bonds, hydrogen bonds between the protein and water molecules, and water bridges with use of molecular dynamics simulation for 38 mutant SOD1 forms. Multiple regression model based on these kinds of bonds demonstrated correlation with patient survival time significantly better (R = .9, p-value < 10−11) than the thermostability of SOD1 mutants only. It was shown that the occupancy of intramolecular hydrogen bonds between amino acid residues is a key determinant (R = .89, p-value < 10−10) in predicting patients’ survival time.
Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential

Noninvasive or minimally invasive prediction of tumor metastatic potential would facilitate individualized cancer management. Studies were performed on a panel of human melanoma xenografts that spanned the full range of metastatic potential measured by an in vivo lung colony assay and an in vitro membrane invasion culture system. Three imaging methods potentially transferable to the clinic [dynamic contrast-enhanced (DCE) MRI, T1ρ-MRI, and low-temperature fluorescence imaging (measurable on biopsy specimens)] distinguished between relatively less metastatic and more metastatic human melanoma xenografts in nude mice. DCE-MRI, analyzed with the shutter-speed relaxometric algorithm and using an arterial input function simultaneously measured in the left ventricle of the mouse heart, yielded a blood transfer rate constant, Ktrans, that measures vascular perfusion/permeability. Ktrans was significantly higher in the core of the least metastatic melanoma (A375P) than in the core of the most metastatic melanoma (C8161). C8161 melanoma had more blood vascular structures but fewer functional blood vessels than A375P melanoma. The A375P melanoma exhibited mean T1ρ values that were significantly higher than those of C8161 melanoma. Measurements of T1 and T2 relaxation times did not differ significantly between these 2 melanomas. The mitochondrial redox ratio, Fp/(Fp + NADH), where Fp and NADH are the fluorescences of oxidized flavoproteins and reduced pyridine nucleotides, respectively, varied linearly with the in vitro invasive potential of the 5 melanoma cell lines (A375P, A375M, A375P10, A375P5, and C8161). This study shows that a harsh microenvironment may promote melanoma metastasis and provides potential biomarkers of metastatic potential.
Worst-Case Power-Constrained Noise for Binary-Input Channels

Additive noise channels with binary-valued inputs and real-valued outputs are considered. The maximum error probability and the minimum channel capacity achieved by any power-constrained noise distribution are obtained. A general framework which applies to a variety of performance measures shows that the least-favorable noise distribution is, in general, a mixture of two lattice probability mass functions. The framework holds for m-ary input constellations on finite-dimensional lattices. >
Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population

Background/Aims An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was performed to estimate the prevalence of CKD in the Korean adult population as defined and classified by the KDIGO guidelines. Methods Cross-sectional samples of the fifth Korean National Health and Nutrition Examination Survey for 2011 to 2012 were examined for adults aged ≥ 19 years. CKD prevalence was determined based on decreased GFR and albuminuria. The GFR was estimated using the CKD Epidemiology Collaboration creatinine equation, and albuminuria was evaluated using the albumin-to-creatinine ratio (ACR) in spot urine. Results Of the 16,576 subjects participating in the survey, 10,636 (4,758 men, 5,878 women) were included in the present study. The prevalence of CKD was estimated as 7.9% (7.8% in 2011 and 8.0% in 2012, p = 0.770). The prevalence of low, moderately increased, high, and very high CKD risk prognosis was 92.0%, 6.3%, 1.1%, and 0.6%, respectively. The prevalence of albuminuria (ACR ≥ 30 mg/g) in individuals with GFR ≥ 60 mL/min/1.73 m2 has reached 5.7%. The odds ratios of hypertension and diabetes to CKD were 3.4 and 3.1 in men, and 2.9 and 2.0 in women (all p < 0.001), respectively. Conclusions A large percentage of CKD patients had albuminuria prior to a decrease in GFR. Regular laboratory tests for albuminuria for the high-risk group, and especially for hypertensive or diabetic patients, might improve detection of CKD at an early stage.
An Empirical Investigation of Passenger Wait Time Perceptions Using Hazard-Based Duration Models

Waiting time in bus stops heavily affects traveler attitude towards public transportation and therefore is an important element for consideration when planning and operating a bus system. Furthermore, what passengers perceive as waiting time is often quite different from their actual waiting time at a bus stop. In this context, we present an empirical investigation of actual and perceived waiting times at bus stops for the case of a large bus network, using hazard-based duration models. The analysis is based on a questionnaire survey undertaken at bus stops of the Athens, Greece, bus network. Results indicate that age, trip purpose, and trip time period seem to have an impact on that perception, with older individuals, work, and education trips being factors that increase perceived waiting time and lead to an overestimation of actual waiting, while perceived waiting time decreases during morning time periods.
Admittance-Adaptive Model-Based Approach to Mitigate Biodynamic Feedthrough

Biodynamic feedthrough (BDFT) refers to the feedthrough of vehicle accelerations through the human body, leading to involuntary control device inputs. BDFT impairs control performance in a large range of vehicles under various circumstances. Research shows that BDFT strongly depends on adaptations in the neuromuscular admittance dynamics of the human body. This paper proposes a model-based approach of BDFT mitigation that accounts for these neuromuscular adaptations. The method was tested, as proof-of-concept, in an experiment where participants inside a motion simulator controlled a simulated vehicle through a virtual tunnel. Through evaluating tracking performance and control effort with and without motion disturbance active and with and without cancellation active, the effectiveness of the cancellation was evaluated. Results show that the cancellation approach is successful: the detrimental effects of BDFT were largely removed.
Histone Modification Pattern of the T-Cellular Herpesvirus Saimiri Genome in Latency

ABSTRACT Herpesvirus saimiri (HVS) subgroup C strains are able to growth transform human T lymphocytes in vitro. The stably persisting and nonintegrating HVS episome represents an optimal prerequisite for the investigation of the epigenetic state of latent herpesvirus genomes in vitro. Quantitative chromatin immunoprecipitation experiments using seven different histone acetylation- or methylation-specific antibodies revealed repressive marks at four lytic gene promoters and a variable pattern at the weakly transcribed LANA/orf73 promoter. The constitutive stpC/tip promoter regulating the viral oncoproteins and, more interestingly, the noncoding repetitive H-DNA elements flanking the coding region, showed a permissive chromatin structure. This study provides an appropriate model for the analysis of epigenetic herpesvirus genome modifications and their dynamics in T cells.