Miracle-dz/UniFAR-FTUs huggingface dataset:
Two-sided Matching with Incomplete Information∗

Stability in a two-sided matching model with non-transferrable utility and with incomplete information is investigated. Each agent has interdependent preferences which depend on his own type and on the possibly unknown types of agents on the other side of the market. In a one-sided incomplete information model in which workers’ types are private information, a firm joins a worker in a block to a matching only if the firm is better off with all types of the worker interested in the potential block. With anonymous preferences, all strictly individually-rational matching-outcomes are one-sided incomplete-information stable. Thus, in a positive assortative matching model all matching outcomes are incompleteinformation stable including the negative assortative match. An ex post incentive compatible mechanism implements the best complete-information stable matching for workers; this mechanism does not assume anonymous preferences. Extensions to two-sided incomplete information stability are investigated. The set of stable matching-outcomes under two-sided incomplete information are a superset of stable matching-outcomes under one-sided incomplete information, which in turn include complete-information stable matchings. ∗I am grateful to Oleg Baranov, Pradeep Dubey, Federico Echenique, Vijay Krishna, Pino Lopomo, Joe Ostroy, and Marek Pycia for helpful comments. †UCLA Anderson School of Management (sbikhcha@anderson.ucla.edu)
Persistent Detection of Varicella-Zoster Virus DNA in a Previously Healthy Child after Severe Chickenpox

ABSTRACT In immunocompetent children with primary varicella-zoster virus (VZV) infection, peak viral loads are detected in peripheral blood near the onset of the vesicular rash. VZV DNA concentrations normally diminish and become undetectable within 3 weeks after the appearance of the exanthem. Here, we present a previously healthy, human immunodeficiency virus-negative, 4-year-old boy admitted with severe varicella. High viral loads (>340,000 copies/ml) were found in his blood, and the viral loads remained high for at least 1.5 years. Clinical recovery preceded complete clearance of the virus. General and VZV-specific immune reactivity were intact. NK cells and CD8+ T cells were activated during acute infection, and VZV-specific CD4+ T cells were detected at high frequencies. VZV DNA was initially detected in B cells, NK cells, and both CD4+ and CD8+ T cells. In contrast, during the persistent phase of VZV DNA detection, the viral DNA was primarily located in CD8+ T cells. For the first time, we describe the persistent detection of VZV DNA in a previously healthy child.
Hepatocellular carcinoma in qatar.

OBJECTIVE The main aim of this study was to report and discuss epidemiological, etiological, type of treatment and data on survival of the patients with each mode of treatment using available data for patients with hepatocellular carcinoma (HCC) who have been diagnosed at Hamad Medical Corporation during the period March 2004-December 2010 inclusive. MATERIALS AND METHODS Retrospective analysis of 150 patient's data had been done, including demographic, epidemiological, etiological disease status assessment with child Pugh criteria, modes of treatment and treatment related outcome. Patient's various characteristics such as demographic, epidemiological, and other clinical characteristics were summarized using an appropriate descriptive statistics. Univariate Kaplan-Meier survival curve analysis was performed to estimate overall and group wise survival at different time points. Furthermore, the log-rank test was applied to determine any statistical difference in survival among various subgroups. In addition, the multivariate Cox regression method was used to assess the significant effects of various prognostic factors on outcome survival time. RESULTS The mean age of the studied HCC patients was 58.8 years (31-87years) with a male: female ratio of 3:1 (76% Male 24% Female). There were 48 (32%) Qatari and 102 (62%) non-Qatari patients. The underlying etiology HCV was the most common (45%) similar to Western European countries, HBV in (27%), alcoholic liver disease only in 6 (4%), Child-Pugh assessment was A in (33%), B in (37%) and C in (30%), nearly half of the patients (53%) were in advanced stage and had palliative treatment, the other half had chemoembolization in (17%), systemic therapy sorafenib in (13%), surgery (liver resection or transplantation) in (12%) and local ablation in (5%). CONCLUSION HCC is more common in males (ratio M:F 3:1). HCV is the most common underlying cause, similar to the pattern in western European countries. The survivals in our patient were comparable to other studies reported in the literature. Patients who had chemoembolization had the longest median survival [Median = 27 months, 95% CI (20.27- 33.72). Majority of cases (53%) were diagnosed at advanced stage. To improve the outcome of treatment of HCC patients, the number of early and very early stage diagnosis should be increased by improving the implementation and effectiveness of the strategic screening program. KEYWORDS Hepatocellular carcinoma, chemoembolization, radiofrequency, sorafenib, hepatitis C, Hepatitis B.
Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population

Background: Several observational studies have reported that higher visit-to-visit blood pressure variability is a risk factor for cognitive impairment and dementia. However, no studies have investigated the association of day-to-day blood pressure variability assessed by home blood pressure measurement with the development of dementia. Methods: A total of 1674 community-dwelling Japanese elderly without dementia, ≥60 years of age, were followed up for 5 years (2007–2012). Home blood pressure was measured 3 times every morning for a median of 28 days. Day-to-day systolic (SBP) and diastolic blood pressure variabilities, calculated as coefficients of variation (CoV) of home SBP and diastolic blood pressure, were categorized into quartiles. The hazard ratios and their 95% confidence intervals of the CoV levels of home blood pressure on the development of all-cause dementia, vascular dementia (VaD), and Alzheimer disease (AD) were computed with a Cox proportional hazards model. Results: During the follow-up, 194 subjects developed all-cause dementia; of these, 47 had VaD and 134 had AD. The age- and sex-adjusted incidences of all-cause dementia, VaD, and AD increased significantly with increasing CoV levels of home SBP (all P for trend <0.05). These associations remained unchanged after adjustment for potential confounding factors, including home SBP. Compared with subjects in the first quartile of CoV levels of home SBP, the risks of the development of all-cause dementia, VaD, and AD were significantly higher in those in the fourth quartile (hazard ratio=2.27, 95% confidence interval=1.45–3.55, P<0.001 for all-cause dementia; hazard ratio=2.79, 95% confidence interval=1.04–7.51, P=0.03 for VaD; hazard ratio=2.22, 95% confidence interval=1.31–3.75, P<0.001 for AD). Similar associations were observed for CoV levels of home diastolic blood pressure. Meanwhile, home SBP levels were significantly associated with the risk of VaD but not with the risks of all-cause dementia and AD. There was no interaction between home SBP levels and CoV levels of home SBP on the risk of each subtype of dementia. Conclusions: Our findings suggest that increased day-to-day blood pressure variability is, independently of average home blood pressure, a significant risk factor for the development of all-cause dementia, VaD, and AD in the general elderly Japanese population.
Experimental hyperhomocysteinaemia: differences in tissue metabolites between homocystine and methionine feeding in a rat model

Aim: Hyperhomocysteinaemia, diagnosed by serum levels, is regarded as an independent risk indicator for cardiovascular events and is associated with various diseases. The pathomechanisms seem to be partly due to concentrations of homocysteine metabolites and their effect on the cellular transmethylation processes.
Signal-Tracing Techniques for In-System FPGA Debugging of High-Level Synthesis Circuits

High-level synthesis (HLS) promises to increase designer productivity in the face of increasing field-programmable gate array sizes, and broaden the market of use, allowing software designers to reap the benefits of hardware implementation. One roadblock to HLS adoption is the lack of an in-system debugging infrastructure. Although designers can run their software code on a workstation, or simulate the register-transfer level, neither can reliably capture the behaviors, and therefore bugs, that may be present in the final system. Debugging hardware circuits in-system requires using signal-tracing to record circuit behavior for later offline analysis. In this paper, we present a debugging architecture, which automatically records key hardware signals, and relates them back to the original software source code. This architecture allows designers to debug HLS circuits in-system, in the context of the original source code. We present several signal-tracing techniques, tailored to HLS circuits, which allow a much longer execution trace to be captured. These techniques include signal compression, dynamically changing which signals are recorded cycle-by-cycle, and offline signal restoration. Compared to using an embedded logic analyzer to perform signal-tracing, our architecture increases the length of execution trace that can be recorded by 127X. For each 100 Kb of trace buffer memory, our architecture can record 15 369 executed lines of C code.
Fast digital locally monotonic regression

Restrepo and Bovik [1993] developed an elegant mathematical framework in which they studied locally monotonic regressions in R/sup N/. The drawback is that the complexity of their algorithms is exponential in N. In this paper, we consider digital locally monotonic regressions, in which the output symbols are drawn from a finite alphabet, and, by a connection to Viterbi decoding, provide a fast O(|A|/sup 2//spl alpha/N) algorithm that computes any such regression, where |A| is the size of the digital output alphabet, /spl alpha/ stands for lomo-degree, and N is sample size. This is linear in N, and it renders the technique applicable in practice.
Radiation effects on MHD free convective boundary layer flow of nanofluidsover a nonlinear stretching sheet

The present study focuses on the numerical solution of a steady free convective boundary-layer flow of a radiating nanofluid along a non-linear stretching sheet in the presence of transverse magnetic field. The model used for the nanofluid incorporates the effects of Brownian motion and thermophoresis. The governing boundary-layer equations of the problem are formulated and transformed into a non-similar form. The resultant equations are then solved numerically using Runge-Kutta fourth order method along with shooting technique. In the absence of radiation parameter, magnetic parameter and for m = 1 (the non-linear stretching parameter), our results showed a good agreement with those of Anwar et al.[36] and also with that of Khan and Pop [34], for further reduced case. The physics of the problem is well explored for the embedded material parameters through graphs and tables. Further there is a scope of researching the reactions taking place in the mixture and the heat source /sink
Spectral tuning by opsin coexpression in retinal regions that view different parts of the visual field

Vision frequently mediates critical behaviours, and photoreceptors must respond to the light available to accomplish these tasks. Most photoreceptors are thought to contain a single visual pigment, an opsin protein bound to a chromophore, which together determine spectral sensitivity. Mechanisms of spectral tuning include altering the opsin, changing the chromophore and incorporating pre-receptor filtering. A few exceptions to the use of a single visual pigment have been documented in which a single mature photoreceptor coexpresses opsins that form spectrally distinct visual pigments, and in these exceptions the functional significance of coexpression is unclear. Here we document for the first time photoreceptors coexpressing spectrally distinct opsin genes in a manner that tunes sensitivity to the light environment. Photoreceptors of the cichlid fish, Metriaclima zebra, mix different pairs of opsins in retinal regions that view distinct backgrounds. The mixing of visual pigments increases absorbance of the corresponding background, potentially aiding the detection of dark objects. Thus, opsin coexpression may be a novel mechanism of spectral tuning that could be useful for detecting prey, predators and mates. However, our calculations show that coexpression of some opsins can hinder colour discrimination, creating a trade-off between visual functions.
Hsa-miR-15a and Hsa-miR-16-1 Expression Is Not Related to Proliferation Centers Abundance and Other Prognostic Factors in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) is the commonest leukemia in adults. Here, we aimed to evaluate hsa-miR-15a/hsa-miR-16-1 expression in CLL tissues by qPCR and correlate it with the other clinicopathological features and clinical outcome. 40 formalin-fixed paraffin-embedded (FFPE) lymph node samples obtained from CLL/SLL patients were classified into two categories, “PCs rich” and “typical. ” We found a significant common expression level of 4 miRNAs; however, we did not find any significant relationship between PCs presence and miRNAs expression. Moreover, neither the presence of 13q deletion nor the percentage of cells carrying the deletion strictly correlated with miRNAs expression levels, although a significant number of patients with 13q deletion presented hsa-miR-16-1-3p levels below the median value in normal samples (P < 0.05). Finally, although no correlation was found between the expression of each miRNA and other clinicopathological features (Ki67, CD38, ZAP70, and IGVH@ hypermutations), the OS curves showed a positive trend in patients with miRNAs downregulation, though not statistically significant. In conclusion, we showed for the first time that all miRNAs can be successfully studied in FFPE CLL tissues and that del13q and PCs richness do not strictly correspond to miRNAs downregulation; therefore, a specific evaluation may be envisaged at least in patients enrolled in clinical trials.
Modeling and Simulation of the Writing Process on Bit-Patterned Perpendicular Media

The recording physics of bit-patterned media is studied for areal densities of around 2 Tbits/inch2 . A model of the writing process, based on the head field gradient and switching field distribution, including various interference fields, is presented to extract the write-head and media parameters which are necessary to attain a wider write margin. Write head field distributions, calculated by the finite-element method, are presented for various head pole structures with side- and trailing-shields to improve head field gradient. Optimization of the pole configuration increased the gradient to over 500 Oe/nm for a head-to-soft magnetic under layer (SUL) spacing of 14 nm. Using the head field distribution, a recording performance analysis by micromagnetic simulation indicated that the write margin was improved. Position and size dispersions of the dots deteriorated the signal-to-noise ratio (SNR) and increased adjacent track erasure (ATE).
Mercator: a fast and simple web server for genome scale functional annotation of plant sequence data.

Next-generation technologies generate an overwhelming amount of gene sequence data. Efficient annotation tools are required to make these data amenable to functional genomics analyses. The Mercator pipeline automatically assigns functional terms to protein or nucleotide sequences. It uses the MapMan 'BIN' ontology, which is tailored for functional annotation of plant 'omics' data. The classification procedure performs parallel sequence searches against reference databases, compiles the results and computes the most likely MapMan BINs for each query. In the current version, the pipeline relies on manually curated reference classifications originating from the three reference organisms (Arabidopsis, Chlamydomonas, rice), various other plant species that have a reviewed SwissProt annotation, and more than 2000 protein domain and family profiles at InterPro, CDD and KOG. Functional annotations predicted by Mercator achieve accuracies above 90% when benchmarked against manual annotation. In addition to mapping files for direct use in the visualization software MapMan, Mercator provides graphical overview charts, detailed annotation information in a convenient web browser interface and a MapMan-to-GO translation table to export results as GO terms. Mercator is available free of charge via http://mapman.gabipd. org/web/guest/app/Mercator.
Adaptive Learning and Monetary Exchange *

This paper investigates three classic questions in monetary theory: How can an intrinsically worthless asset maintain value as a medium of exchange? What are the short-run and long-run eects of a change in the money supply? What is the social cost of a money growth policy? I answer these questions using a microfounded model of monetary exchange that replaces the rational expectations assumption with an adaptive learning rule. First, I show that monetary exchange is a robust arrangement in the sense that agents are able to learn the stationary monetary equilibrium while the nonmonetary equilibrium is unstable under learning. Second, an unanticipated monetary injection has real eects in the short-run because learning the value of money takes time. In the long run, agents successfully learn the value of money, hence money is neutral. Third, under a constant money growth policy, an increase in the growth rate of money increases output in the short-run producing a short-run Phillips curve. A ten percent increase in the money growth rate has a social cost of 0.41 percent of output per year. Alternatively, a ten percent decrease in the money growth rate has a social benet of 0.37 percent of output per year.
Inhibition of TMEM16A Expression Suppresses Growth and Invasion in Human Colorectal Cancer Cells

Metastasis leads to poor prognosis in colorectal cancer patients, and there is a growing need for new therapeutic targets. TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as a calcium-activated chloride channel (CaCC) and is reported to be overexpressed in several malignancies; however, its expression and function in colorectal cancer (CRC) remains unclear. In this study, we found expression of TMEM16A mRNA and protein in high-metastatic-potential SW620, HCT116 and LS174T cells, but not in primary HCT8 and SW480 cells, using RT-PCR, western blotting and immunofluorescence labeling. Patch-clamp recordings detected CaCC currents regulated by intracellular Ca2+ and voltage in SW620 cells. Knockdown of TMEM16A by short hairpin RNAs (shRNA) resulted in the suppression of growth, migration and invasion of SW620 cells as detected by MTT, wound-healing and transwell assays. Mechanistically, TMEM16A depletion was accompanied by the dysregulation of phospho-MEK, phospho-ERK1/2 and cyclin D1 expression. Flow cytometry analysis showed that SW620 cells were inhibited from the G1 to S phase of the cell cycle in the TMEM16A shRNA group compared with the control group. In conclusion, our results indicate that TMEM16A CaCC is involved in growth, migration and invasion of metastatic CRC cells and provide evidence for TMEM16A as a potential drug target for treating metastatic colorectal carcinoma.
Silicon Nanowire Tunneling Field-Effect Transistor Arrays: Improving Subthreshold Performance Using Excimer Laser Annealing

We have experimentally established that the inverse subthreshold slope S of a Si nanowire tunneling field-effect transistor (NW-TFET) array can be within 9% of the theoretical limit when the doping profile along the channel is properly engineered. In particular, we have demonstrated that combining excimer laser annealing with a low-temperature rapid thermal anneal results in an abrupt doping profile at the source/channel interface as evidenced by the electrical characteristics. Gate-controlled tunneling has been confirmed by evaluating S as a function of temperature. The good agreement between our experimental data and simulation allows performance predictions for more aggressively scaled TFETs. We find that Si NW-TFETs can be indeed expected to deliver S-values below 60 mV/dec for optimized device structures.
Increased reactive oxygen species and exhaustion of quiescent CD34-positive bone marrow cells may contribute to poor graft function after allotransplants

Poor graft function (PGF) is a fatal complication following allogeneic haematopoietic stem cell transplantation. However, the underlying mechanism is unclear. Effective cross-talk between haematopoietic stem cells (HSCs) and bone marrow microenvironment is important for normal haematopoiesis. Normal HSCs reside in a hypoxic bone marrow microenvironment that protects them from oxidative stress that would otherwise inhibit their self-renewal and results in bone marrow failure. Whether an increased level of reactive oxygen species (ROS) causes PGF following allotransplant is unclear. Using a prospective case-pair study, we identified increased levels of ROS in CD34+ bone marrow cells in subjects with PGF. Elevated ROS levels was associated with an increased frequency of DNA strand breaks, apoptosis, exhaustion of quiescent CD34+ cells and defective colony-forming unit plating efficiency, particularly in the CD34+CD38− fraction. Up-regulated intracellular p53, p21, caspase-3 and caspase-9 levels (but not p38) were detected in CD34+ cells, particularly in the CD34+CD38− fraction. To further study the potential role of ROS levels in post-transplant haematopoiesis, CD34+ bone marrow cells from subjects with good graft function were treated with H2O2. This increased ROS levels resulting in defective CD34+ cells, an effect partially reversed by N-acetyl-L-cysteine. Moreover, CD34+ bone marrow cells from the donors to subjects with poor or good graft function exhibited comparable haematopoietic reconstitution capacities in the xeno-transplanted NOD-PrkdcscidIL2rgnull mice. Thus, even if the transplanted donors' bone marrow CD34+ cells are functionally normal pre-transplant, ROS-induced apoptosis may contribute to the exhaustion of CD34+ bone marrow cells in subjects with PGF following allotransplant.
SAuth: protecting user accounts from password database leaks

Password-based authentication is the dominant form of access control in web services. Unfortunately, it proves to be more and more inadequate every year. Even if users choose long and complex passwords, vulnerabilities in the way they are managed by a service may leak them to an attacker. Recent incidents in popular services such as LinkedIn and Twitter demonstrate the impact that such an event could have. The use of one-way hash functions to mitigate the problem is countered by the evolution of hardware which enables powerful password-cracking platforms. In this paper we propose SAuth, a protocol which employs authentication synergy among different services. Users wishing to access their account on service S will also have to authenticate for their account on service V, which acts as a vouching party. Both services S and V are regular sites visited by the user everyday (e.g., Twitter, Facebook, Gmail). Should an attacker acquire the password for service S he will be unable to log in unless he also compromises the password for service V and possibly more vouching services. SAuth is an extension and not a replacement of existing authentication methods. It operates one layer above without ties to a specific method, thus enabling different services to employ heterogeneous systems. Finally we employ password decoys to protect users that share a password across services.