Miracle-dz/UniFAR-FTUs huggingface dataset:
Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia.

OBJECTIVE The current literature emphasizes increased risk of adverse outcomes in the presence of proteinuria and hypertension. The objective of this study was to compare the frequency of adverse fetal outcomes in women who developed hypertensive disorders with or without proteinuria. STUDY DESIGN The study design was a secondary analysis of data from women who had preeclampsia in a previous pregnancy (n = 598) who were enrolled in a multicenter trial of aspirin for the prevention of preeclampsia. The women had no history of chronic hypertension or renal disease and were normotensive at study inclusion. The maternal and perinatal outcome variables assessed were preterm delivery at <37 and <35 weeks of gestation, rate of small-for-gestational-age infants, and abruptio placenta. Data were analyzed by using the chi-square test, and women who remained normotensive or who had mild gestational hypertension were considered as a single group because they had similar outcomes. RESULTS As compared to mild preeclampsia, women who developed severe gestational hypertension (without proteinuria) had higher rates of both preterm delivery at <37 weeks of gestation and small-for-gestational-age infants. In addition, when compared to women with mild preeclampsia, for women with severe gestational hypertension, gestational age and birth weight were significantly lower at delivery (P <.003 for both age and birth weight). Moreover, women who developed severe gestational hypertension had higher rates of preterm delivery at <37 weeks of gestation (54.2% vs 17.8%, P =.001) and at <35 weeks of gestation (25.0% vs 8.4%, P =.0161), and delivery of small-for-gestational-age infants (20.8% vs 6.5%, P =.024) when compared to women who remained normotensive or those who developed mild gestational hypertension. There were no statistically significant differences in perinatal outcomes between the normotensive/mild gestational hypertension and the mild preeclampsia groups. Overall, women who had severe gestational hypertension had increased rates of preterm delivery and delivery of small-for-gestational-age infants than women with mild gestational hypertension or mild preeclampsia. In the presence of severe hypertension, proteinuria did not increase the rates of preterm delivery or delivery of small-for-gestational-age infants. CONCLUSIONS In women who have gestational hypertension or preeclampsia, increased rates of preterm delivery and delivery of small-for-gestational-age infants are present only in those with severe hypertension. In these women, the presence of proteinuria does not influence perinatal outcome.
Effect of Sodium Alginate on Dextran Sulfate Sodium- and 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Experimental Colitis in Mice

We evaluated the effects of sodium alginate (AL-Na) on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. DSS was added to the drinking water for 7 days. In another experiment, DSS was added to the drinking water for 5 days and DSS-free water was provided thereafter. In a separated study, colitis was induced by intrarectally administered TNBS. AL-Na, 5-aminosalicylic acid, or prednisolone was orally administered. These colitis models exhibited colonic damage and produced noticeable inflammatory responses and aggravated goblet cell damage. AL-Na significantly ameliorated DSS- and TNBS-induced experimental colitis and prevented goblet cell damage. Prednisolone also suppressed colitis but caused loss of body and spleen weight. In contrast, AL-Na did not provoke these symptoms. These data suggest that AL-Na may be a possible therapeutic agent for the treatment of inflammatory bowel disease.
Strategic Voting Under the Qualified Majority Rule

This is an analysis of strategic voting under the qualified majority rule. Existing formal analyses of the plurality rule predict the complete coordination of strategic voting: A strict interpretation of Duvergers Law. This conclusion is rejected. Unlike previous models, the popular support for each option is not commonly certain. Agents base their vote on both public and private signals of popular support. When private signals are the main source of information, the uniquely stable equilibrium entails only limited strategic voting and hence partial coordination. This is due to the surprising presence of negative feedback: An increase in strategic voting by others reduces the incentive for a rational voter to act strategically. The theory leads to the conclusion that multi-candidate support in a plurality electoral system is perfectly consistent with rational voting behaviour.
Repair of ionizing radiation-induced DNA damage and risk of second cancer in childhood cancer survivors.

The study's purpose was to assess whether individuals who developed a second malignant neoplasm (SMN) after treatment for a first malignant neoplasm (FMN) had a lower ability to repair DNA double-strand breaks (DSBs) using a bioassay with γH2AX intensity as a surrogate endpoint. In a case-control study nested in a cohort of childhood cancer survivors, lymphoblastoid cell lines (LCLs) were established from blood samples collected from 94 cases (SMN) and 94 matched controls (FMN). LCLs were irradiated with ionizing radiation (2 and 5 Gy) and γH2AX intensities measured 1, 3, 5 and 24h post-irradiation. Differences in mean γH2AX intensity between cases and controls were compared using Kruskal-Wallis tests. Generalized linear models for repeated measures and conditional logistic regressions for SMN risk estimates were performed. The mean baseline γH2AX intensity measured without irradiation was 9.1 [95% confidence interval (95% CI): 8.5-9.7] in the LCLs from cases and 6.4 (95% CI: 6.0-6.8) from controls (P < 0.001). Markedly higher γH2AX intensity, particularly at 1 h post-irradiation, was also found in the LCLs from the cases compared with the controls for all FMNs and for different types of FMN. Chemotherapy and radiation doses received by bone marrow and thymus for FMN treatment showed a non-significant effect on γH2AX intensity. This case-control study shows that higher baseline and post-irradiation levels of DNA DSBs, as measured by γH2AX intensity, are associated with the risk of SMN in childhood cancer survivors. Further investigations in a prospective setting are warranted to confirm this association.
The Moral Dimensions of Teaching: Language, Power, and Culture in Classroom Interaction

Cary Buzzelli and Bill Johnson reinvigorate the enduring question: What is the place of morality in the classroom? Departing from notions of a morality that can only be abstract and absolute, these authors ground their investigation in analyses of actual teacher-student interactions. This approach illuminates the ways in which language, power and culture impact "the moral" in teaching. Buzzelli and Johnson's study addresses a wide range of moral issues in various classroom contexts. Its practical and diverse examples make it a valuable resource for teachers and teacher development programs.
Compressive Fresnel Holography

Compressive sensing is a relatively new measurement paradigm which seeks to capture the “essential” aspects of a high-dimensional object using as few measurements as possible. In this work we demonstrate successful application of compressive sensing framework to digital Fresnel holography. It is shown that when applying compressive sensing approach to Fresnel fields a special sampling scheme should be adopted for improved results.
Perioperative intravenous iron, with or without erythropoietin, plus restrictive transfusion protocol reduce the need for allogeneic blood after knee replacement surgery

BACKGROUND: Unilateral total knee replacement (TKR) results in a substantial blood loss and 30 to 50 percent of patients receive allogeneic blood transfusion (ABT). Therefore, the effectiveness of a restrictive transfusion trigger (hemoglobin [Hb] level < 8 g/dL) plus stimulation of erythropoiesis was evaluated, with or without blood salvage, for reducing ABT in TKR patients.
Electrochemically Assisted Microbial Production of Hydrogen from Acetate

Hydrogen production via bacterial fermentation is currently limited to a maximum of 4 moles of hydrogen per mole of glucose, and under these conditions results in a fermentation end product (acetate; 2 mol/mol glucose) that bacteria are unable to further convert to hydrogen. It is shown here that this biochemical barrier can be circumvented by generating hydrogen gas from acetate using a completely anaerobic microbial fuel cell (MFC). By augmenting the electrochemical potential achieved by bacteria in this MFC with an additional voltage of 250 mV or more, it was possible to produce hydrogen at the cathode directly from the oxidized organic matter. More than 90% of the protons and electrons produced by the bacteria from the oxidation of acetate were recovered as hydrogen gas, with an overall Coulombic efficiency (total recovery of electrons from acetate) of 60-78%. This is equivalent to an overall yield of 2.9 mol H2/mol acetate (assuming 78% Coulombic efficiency and 92% recovery of electrons as hydrogen). This bio-electrochemically assisted microbial system, if combined with hydrogen fermentation that produces 2-3 mol H2/mol glucose, has the potential to produce ca. 8-9 mol H2/mol glucose at an energy cost equivalent to 1.2 mol H2/mol glucose. Production of hydrogen by this anaerobic MFC process is not limited to carbohydrates, as in a fermentation process, as any biodegradable dissolved organic matter can theoretically be used in this process to generate hydrogen from the complete oxidation of organic matter.
Colour Association with Music Is Mediated by Emotion: Evidence from an Experiment Using a CIE Lab Interface and Interviews

Crossmodal associations may arise at neurological, perceptual, cognitive, or emotional levels of brain processing. Higher-level modal correspondences between musical timbre and visual colour have been previously investigated, though with limited sets of colour. We developed a novel response method that employs a tablet interface to navigate the CIE Lab colour space. The method was used in an experiment where 27 film music excerpts were presented to participants (n = 22) who continuously manipulated the colour and size of an on-screen patch to match the music. Analysis of the data replicated and extended earlier research, for example, that happy music was associated with yellow, music expressing anger with large red colour patches, and sad music with smaller patches towards dark blue. Correlation analysis suggested patterns of relationships between audio features and colour patch parameters. Using partial least squares regression, we tested models for predicting colour patch responses from audio features and ratings of perceived emotion in the music. Parsimonious models that included emotion robustly explained between 60% and 75% of the variation in each of the colour patch parameters, as measured by cross-validated R 2. To illuminate the quantitative findings, we performed a content analysis of structured spoken interviews with the participants. This provided further evidence of a significant emotion mediation mechanism, whereby people tended to match colour association with the perceived emotion in the music. The mixed method approach of our study gives strong evidence that emotion can mediate crossmodal association between music and visual colour. The CIE Lab interface promises to be a useful tool in perceptual ratings of music and other sounds.
β-Alanine dose for maintaining moderately elevated muscle carnosine levels.

INTRODUCTION Chronic β-alanine (BA) supplementation is an increasingly popular nutritional strategy, because it can elevate muscle carnosine content and thereby enhance high-intensity exercise performance. The current study investigated 1) whether sex and body mass are determinants of BA-induced muscle carnosine loading and 2) the optimal maintenance dose for ensuring constantly elevated muscle carnosine stores. METHODS During the loading phase, 34 participants (men and women) were supplemented with 3.2 g (4 × 800 mg) BA per day for 46 d (slightly different loading strategies were applied concerning the effect of meal timing and supplementation form). Thereafter, 19 participants (men and women) continued taking free-powder BA for six more weeks (maintenance phase). The participants were matched and redivided into three groups receiving 0.4, 0.8, and 1.2 g·d(-1) BA, respectively. Muscle carnosine content was measured in the soleus and gastrocnemius muscles using proton magnetic resonance spectroscopy. RESULTS Body mass and sex had only minimal effect on the absolute increase in muscle carnosine. Given the lower baseline values in women, the relative increase for women was higher, indicating that women required less BA for the same relative increase. In addition, a significant negative correlation was observed between body mass and the relative increase in muscle carnosine (r = -0.45, P = 0.007). A maintenance dose of ∼1.2 g·d(-1) BA was the most effective in keeping muscle carnosine content elevated at the postsupplementation level. CONCLUSIONS Sex and body mass did not markedly affect the absolute increase during muscle carnosine loading, although they are determinants for the relative increase. In addition, we established for the first time an effective maintenance dose of ∼1.2 g·d(-1) BA to keep muscle carnosine content elevated at 30%-50% above baseline for a prolonged period.
The association between self-esteem and happiness differs in relationally mobile vs. stable interpersonal contexts

Does a change in the nature of surrounding social context affect the strength of association between self-esteem and happiness? This paper aims to answer this question from a socio-ecological perspective, focusing on the role of relational mobility. Recent research has shown that this association is stronger in societies that are higher in relational mobility, where there is a greater freedom of choice in interpersonal relationships and group memberships. In this study, we tested if this hypothesis could be applied to situational differences within the same physical setting. Using a quasi-experimental design, we tested if the association between self-esteem and happiness was stronger for first-year students at a Japanese university who had just entered the college and thus were in a relatively higher mobility context, than the second-year students at the same university whose relationships tended to be more stable and long-standing. The results showed, as predicted, that the association between self-esteem and happiness was stronger for the first-year students than for the second-year students. Implications for the theory and research on social change are discussed.
Cultural Citizenship and Cosmopolitan Practice: Global Youth Communicate Online

Calls now abound in a range of literatures “philosophy, education, sociology, anthropology, media studies;” to reimagine citizenship and identity in ways befitting a global age. A concept predominant in many such calls is the ancient idea of cosmopolitanism. Refashioned now to serve as a compass in a world that is at once radically interconnected and increasingly divided, a cosmopolitan point of view remains resiliently hopeful, asserting that people can both uphold local commitments and take into consideration larger arenas of concern. This article animates theorizing about cultural citizenship, identity formation, and communication with an examination of what might be considered sites for cosmopolitan practice’ an online international social network and offline local programs designed to engage youth in representing themselves and interacting with the representations of others. Specifically, we report our initial research with a group of teenage girls in India, tracing their participation online and offline and their cosmopolitan imaginings of self and other. We hope that this work with young people worlds away geographically, culturally, and ideologically will speak to English educators in the United States who feel likewise compelled to support their students in developing twenty-first-century literacies’ both the technological competencies and the values, knowledge, and dispositions’needed to participate confidently and critically as citizens of local and global worlds.
Altered Hepatic Gene Expression of Enzymes Involved in Energy Metabolism in the Growth-Retarded Fetal Rat

Intrauterine growth retardation (IUGR) resulting from placental insufficiency is a common complication of pregnancy. Bilateral uterine artery ligation of the pregnant rat is a model which mimics intrauterine growth retardation in the human. IUGR rat fetuses have altered hepatic energy and redox states, with reduced fetal hepatic ATP/ADP ratio, increased cytosolic NAD+/NADH ratio, and decreased mitochondrial NAD+/NADH ratio. These critical changes in energy metabolism contribute to IUGR. The effects of these changes at the molecular level are largely unknown. To address these effects we compared hepatic mRNA populations of IUGR and normal fetuses and neonates using mRNA differential display, a polymerase chain reaction-based method for assaying transcriptional differences under various conditions. We isolated and sequenced 18 cDNA products whose mRNA levels were elevated in IUGR compared with normal fetal and neonatal liver. These analyses demonstrated that NADH-ubiquinone oxireductase subunit 4L mRNA (ND-4L) was significantly increased in liver of IUGR fetuses and neonates. This suggested that IUGR may be associated with altered expression of genes involved in the generation of ATP and NADH. Therefore, we measured mRNA levels of adeninenucleotide translocator-2 (ANT-2), glucose-6-phosphate dehydrogenase(G6PD), mitochondrial malate dehydrogenase (MMD), ornithine transcarbamylase(OTC), and phosphofructokinase-2 (PFK-2) using a semiquantitative reverse transcriptase-polymerase chain reaction-based technique. In the IUGR fetus, ND-4L, ANT-2, G6PD, and MMD mRNA levels were significantly elevated; PFK-2 mRNA levels were unchanged, and OTC levels were decreased. In the IUGR newborn rat, mRNA levels of all 6 enzymes were increased suggesting that the metabolic state of the growth retarded newborn remains abnormal after birth. Uteroplacental insufficiency affects the immediate and long-term metabolic milieu of the growth retarded animal, and forces specific adjustments, including the expression of mRNA encoding enzymes involved with hepatic energy production.
Understanding Interactions between Manganese Oxide and Gold That Lead to Enhanced Activity for Electrocatalytic Water Oxidation

To develop active nonprecious metal-based electrocatalysts for the oxygen evolution reaction (OER), a limiting reaction in several emerging renewable energy technologies, a deeper understanding of the activity of the first row transition metal oxides is needed. Previous studies of these catalysts have reported conflicting results on the influence of noble metal supports on the OER activity of the transition metal oxides. Our study aims to clarify the interactions between a transition metal oxide catalyst and its metal support in turning over this reaction. To achieve this goal, we examine a catalytic system comprising nanoparticulate Au, a common electrocatalytic support, and nanoparticulate MnOx, a promising OER catalyst. We conclusively demonstrate that adding Au to MnOx significantly enhances OER activity relative to MnOx in the absence of Au, producing an order of magnitude higher turnover frequency (TOF) than the TOF of the best pure MnOx catalysts reported to date. We also provide evidence that it is a local rather than bulk interaction between Au and MnOx that leads to the observed enhancement in the OER activity. Engineering improvements in nonprecious metal-based catalysts by the addition of Au or other noble metals could still represent a scalable catalyst as even trace amounts of Au are shown to lead a significant enhancement in the OER activity of MnOx.
The Search for the Secure Base: Attachment Theory and Psychotherapy

The Psychological Defense System. The Six Domains of Attachment-based Therapy. Attachment Theory and Psychoanalysis - Finding a Common Language. Attachment in Clinical Practice. An Attachment Perspective on Change in Psychotherapy. Disorganised Attachment and the Basic Fault. Attachment and the 'Storied Self'. Narrative, Psychoanalysis and Attachment. Abuse and Trauma - An Attachment Perspective. Art, Attachment and Psychotherapy. Money and Psychotherapy. Endings in Psychotherapy.
Infrared to millimetre photometry of ultra-luminous ir galaxies: new evidence favouring a 3-stage dust model

Infrared to millimetre spectral energy distributions (SEDs) have been obtained for 41 bright ultra- luminous infrared galaxies (ULIRGs). The observations were carried out with ISOPHOT between 10 and 200 m and supplemented for 16 sources with JCMT/SCUBA at 450 and 850 m and with SEST at 1.3 mm. In addition, seven sources were observed at 1.2 and 2.2 m with the 2.2 m telescope on Calar Alto. These new SEDs represent the most complete set of infrared photometric templates obtained so far on ULIRGs in the local universe. The SEDs peak at 60{100 m and show often a quite shallow Rayleigh-Jeans tail. Fits with one single modied blackbody yield a high FIR opacity and small dust emissivity exponent T >30 K) to cold (30 K >T >10 K) temperatures. This provides evidence for two dust stages, the cool starburst dominated one and the cold cirrus-like one. The third stage with several hundred Kelvin warm dust is identied in the AGN dominated ULIRGs, showing up as a NIR-MIR power- law flux increase. While AGNs and SBs appear indistinguishable at FIR and submm wavelengths, they dier in the NIR-MIR. This suggests that the cool FIR emitting dust is not related to the AGN, and that the AGN only powers the warm and hot dust. In comparison with optical and MIR spectroscopy, a criterion based on the SED shapes and the NIR colours is established to reveal AGNs among ULIRGs. Also the possibility of recognising evolutionary trends among the ULIRGs via the relative amounts of cold, cool and warm dust components is investigated.