Miracle-dz/UniFAR-FTUs huggingface dataset:
Probing the centre of the large circumstellar disc in M 17

We investigated the nature of the hitherto unresolved elliptical infrared emission in the centre of the ∼20000 au disc silhouette in M 17. We combined high-resolution JHK s L' M'-band imaging carried out with Nasmyth Adaptive Optics System/Coude Near Infrared Camera (NAOS/CONICA) at the Very Large Telescope (VLT) with [Fe n] narrow-band imaging using SOFI [Son of ISAAC (Infrared Spectrograph and Array Camera)] at the New Technology Telescope (NTT). The analysis is supported by Spitzer/GLIMPSE archival data and by already published Spectrograph for Integral Field Observations in the Near Infrared (SINFONI)/VLT Integral Field Spectroscopy data. For the first time, we resolve the elongated central infrared emission into a point source and a jet-like feature that extends to the northeast in the opposite direction of the recently discovered collimated H 2 jet. They are both orientated almost perpendicular to the disc plane. In addition, our images reveal a curved southwestern emission nebula whose morphology resembles that of the previously detected northeastern one. Both nebulae are located at a distance of 1500 au from the disc centre. We describe the infrared point source in terms of a protostar that is embedded in circumstellar material producing a visual extinction of 60 ≤ A v < 82. The observed K s -band magnitude is equivalent to a stellar mass range of 2.8 M ⊙ ≤ M * ≤ 8 M ⊙ adopting conversions for a main-sequence star. Altogether, we suggest that the large M 17 accretion disc is forming an intermediate to high-mass protostar. Part of the accreted material is expelled through a symmetric bipolar jet/outflow.
Like Milk or Wine: Does Firm Performance Improve with Age?

Our empirical literature review shows that little is known about how firm performance changes with age, presumably because of the paucity of data on firm age. For Spanish manufacturing firms, we analyse the firm performance related to firm age between 1998 and 2006. We find evidence that firms improve with age, because ageing firms are observed to have steadily increasing levels of productivity, higher profits, larger size, lower debt ratios, and higher equity ratios. Furthermore, older firms are better able to convert sales growth into subsequent growth of profits and productivity. On the other hand, we also found evidence that firm performance deteriorates with age. Older firms have lower expected growth rates of sales, profits and productivity, they have lower profitability levels (when other variables such as size are controlled for), and also that they appear to be less capable to convert employment growth into growth of sales, profits and productivity.
Fast-responsive link adaptation for IEEE 802.11 WLANs

The mechanism to select one out of multiple available transmission rates at a given time is referred to as link adaptation. The effectiveness of a link adaptation scheme depends on how fast it can respond to the wireless channel variation. In this paper, we propose a truly-adaptive fast-responsive link adaptation scheme for IEEE 802.11 WLAN (wireless LAN). The key idea is to direct the transmitter station's rate-increasing attempts in a controlled manner such that the responsiveness of the link adaptation scheme can be guaranteed with minimum number of rate-increasing attempts. Since our scheme allows the transmitter station to make the link adaptation decision solely based on its local acknowledgment information, it does not require any change to the current 802.11 standard, thus facilitating its deployment with existing 802.11 devices. Our in-depth simulation shows that our scheme yields significantly higher throughput than other existing schemes including single-rate schemes, the ARF (auto rate fallback) scheme and its variants, in various fading channels.
Stability of individual elements under one-parameter semigroups

Let {T(t): t > O} be a C0-semigroup on a Banach space X with generator A, and let x E X. If a(A) n iR is empty and t 4 T(t)x is uniformly continuous, then IIT(t)xII -+ 0 as t -+ oo. If the semigroup is sun-reflexive, a(A) n iR is countable, Pa(A) n iR is empty, and t 4 T(t)x is uniformly weakly continuous, then T(t)x -0 weakly as t --oo . Questions of almost periodicity and of stabilization of contraction semigroups on Hilbert space are also discussed.
Self-Determination and Women's Rights in Muslim Societies

Contradicting the views commonly held by westerners, many Muslim countries in fact engage in a wide spectrum of reform, with the status of women as a central dimension. This anthology counters the myth that Islam and feminism are always or necessarily in opposition. A multidisciplinary group of scholars examine ideology, practice, and reform efforts in the areas of marriage, divorce, abortion, violence against women, inheritance, and female circumcision across the Islamic world, illuminating how religious and cultural prescriptions interact with legal norms, affecting change in sometimes surprising ways.
Multidisciplinary Care Improves Survival of Patients with Amyotrophic Lateral Sclerosis in the Unique Health System (SUS) in Brazil

Objective: To determine the effectiveness of multi-professional palliative care in patients with amyotrophic lateral sclerosis in Brazilian public health system. Methods: Historic-control study before and after the Reference Center, with records and mortality data of 302 patients treated with riluzole between 2005 and 2015, were retrospectively evaluated and survival curves were analyzed. Results: There were 181 men (59.9%) and 121 women (40.1%) with a diagnostic delay time of 28.1 months for spinal-onset and 20.1 months for bulbar-onset (p=0.003) and a mean survival of 61.7 ± 5.4 months for spinal-onset and 38 ± 3.5 months for bulbar-onset (p=0.01). Electromyography did not confirm the diagnosis in 55.6% of the suspected spinal-onset cases and 36.1% of the bulbar-onset. From 2005 to 2011, mean survival was 33.6 ± 2.4 months, and after multidisciplinary care, 72.2 ± 7.2 months (log-rank: 0.0001). Conclusion: Multidisciplinary care improves the survival of amyotrophic lateral sclerosis patients in the Unique Health System.
Exogenous human recombinant interleukin-10 attenuates hindlimb ischemia-reperfusion injury.

Proinflammatory cytokines have been found to mediate part of the local and distant organ injury after ischemia and reperfusion (I/R). The anti-inflammatory cytokine interleukin-10 (IL-10) inhibits both TNF-alpha and IL-1, and we hypothesized that exogenous human IL-10 may decrease lung and soleus muscle injury after hindlimb I/R. Male Sprague-Dawley rats were randomly assigned to I/R (n = 10); I/R+IL-10 (10 micrograms i.v., n = 10), SHAM (n = 4); or SHAM+IL-10 (10 micrograms i.v., n = 4). Bilateral hindlimb ischemia was produced by tourniquet occlusion for 4 hr and all animals were sacrificed after 4 hr of reperfusion or at comparable times for the SHAMs. Soleus muscle cellular injury was determined by uptake of 99Tc pyrophosphate while soleus muscle capillary permeability, and lung capillary permeability were assessed by uptake of 125I-labeled albumin. Soleus muscle and lung neutrophil infiltration were measured with the myeloperoxidase assay. Serum samples were assessed for TNF-alpha production with the WEHI bioassay. Hindlimb I/R caused significant soleus muscle cellular injury, soleus muscle capillary injury, lung capillary injury, and lung neutrophil infiltration, Pretreatment with exogenous IL-10 significantly reduced soleus muscle capillary permeability and also reduced soleus muscle cellular injury, but not to a statistically significant degree. IL-10 administration also reduced pulmonary capillary permeability despite significantly increased lung neutrophil infiltration. Elevated TNF-alpha levels were found in 66% (4/6) rats in the I/R group versus 30% (3/10) rats in the I/R+IL-10 group. Exogenous IL-10 attenuates both local and distant organ injury after hindlimb I/R potentially independent of neutrophil infiltration.
Development and Stem Cells Research Article

INTRODUCTION During animal development, stem cells progressively lose their multipotency and their progeny's fates are increasingly restricted. Moreover, once cell fate begins to be restricted, including in non-totipotent progenitors, cells maintain their differentiated characteristics and cannot revert to stem cells in vivo, although they can dedifferentiate into stem cells when forced to express certain defined factors in vitro (Takahashi and Yamanaka, 2006). For cell fates to be stably maintained in vivo, the gene expression program must also be maintained. Epigenetic mechanisms, including DNA methylation and histone modifications, are believed to play important roles in maintaining transcriptional programs. Among histone modifications, the roles of histone methylation in the maintenance of cell fate are relatively well understood. For example, in Drosophila, the polycomb genes, which include the genes for the histone methyltransferase, E(z), and for methylated histone binding protein (Polycomb), are required for the maintenance of cell fates through the transcriptional silencing of Hox genes (Ringrose and Paro, 2004). In mammals, an H3K4 histone methyltransferase, MLL, is crucial for the maintenance of memory Th2 cell function (Yamashita et al., 2006). However, unlike histone methylation, the well-described roles of histone acetylation are in transcriptional activation per se and in cell differentiation, but its roles in the maintenance of cell fate are poorly understood. BET-family proteins are evolutionally conserved and have two bromodomains, which recognize acetylated histones (Florence and Faller, 2001; Loyola and Almouzni, 2004). In Saccharomyces cerevisiae, the BET-family protein Bdf1 has an anti-silencing function that prevents the spreading of the SIR silencing complex from the telomere or mating loci (Ladurner et al., 2003). In
Did Pterosaurs Feed by Skimming? Physical Modelling and Anatomical Evaluation of an Unusual Feeding Method

Similarities between the anatomies of living organisms are often used to draw conclusions regarding the ecology and behaviour of extinct animals. Several pterosaur taxa are postulated to have been skim-feeders based largely on supposed convergences of their jaw anatomy with that of the modern skimming bird, Rynchops spp. Using physical and mathematical models of Rynchops bills and pterosaur jaws, we show that skimming is considerably more energetically costly than previously thought for Rynchops and that pterosaurs weighing more than one kilogram would not have been able to skim at all. Furthermore, anatomical comparisons between the highly specialised skull of Rynchops and those of postulated skimming pterosaurs suggest that even smaller forms were poorly adapted for skim-feeding. Our results refute the hypothesis that some pterosaurs commonly used skimming as a foraging method and illustrate the pitfalls involved in extrapolating from limited morphological convergence.
Multiple dimensions of human resource development and organizational performance

Summary Building on strategic human resource management literature, this study investigates the effects of various human resource development (HRD) dimensions on organizational performance. We identify four distinct dimensions of HRD that reflect either quantitative or qualitative approaches from either managerial or employee perspectives. Furthermore, we propose that HRD affects organizational performance by shaping employee outcomes, a prevailing but rarely tested assumption. Multi-source data collected from 207 manufacturing companies at three time points over a 5-year period largely support our theoretical propositions. A series of structural path analyses confirm that HRD improves employee commitment and competence, which in turn determine the financial performance of the organization. The quantitative dimensions of HRD (resource investment in HRD) predict only employee commitment. By contrast, the qualitative dimensions of HRD (management support for, and perceived benefits of, HRD) enhance both employee commitment and competence. Our analysis also demonstrates synergistic interactions between the quantitative and qualitative dimensions of HRD in predicting employee outcomes. This study elaborates the distinct values of different dimensions of HRD and highlights the significance of employee outcomes as the mediating mechanism between HRD and firm performance. Copyright © 2014 John Wiley & Sons, Ltd.
Dual regulation of osteopontin production by TLR stimulation in dendritic cells

OPN, a cytokine produced, among others, by DCs, is involved in inflammation and defense against pathogens. Here, we report that the activation of the MyD88 pathway by TLR2, TLR5, and TLR7/8 agonists or IL‐1β induces high levels of OPN in human DCs. Conversely, LPS and Poly I:C, two TLR3 and TLR4 agonists that engage the TRIF pathway, were ineffective. TLR2 agonists were the strongest OPN inducers, and OPN production was highly stimulated by TLR2‐triggering bacteria (Staphylococcus aureus) but not by TLR4‐triggering Escherichia coli. Costimulation experiments revealed that TLR3 and TLR4 agonists, beyond being inactive by themselves, sharply limited TLR2‐dependent OPN production by activating a TRIF‐dependent inhibition of the MyD88‐dependent OPN production. MyD88 silencing impaired TLR2‐dependent OPN induction, whereas TRIF pathway blockage by chloroquine, dynasore, or TRIF knockdown prevented the TLR3/4 agonist‐mediated inhibition, which was independent from the endogenous production of type I IFN, IL‐29, IL‐10, or TGF‐β. LPS and Poly I:C inhibitory activity was associated with the release of a >10‐kDa protein factor(s). We also demonstrated that the higher OPN levels produced by S. aureus‐treated DCs compared with E. coli‐treated DCs were responsible for a markedly increased production of IL‐17 by CD4+ T cells. These results highlight the biological relevance of the differential OPN induction by TLR2 and TLR4 agonists and emphasize the importance of TLR cross‐talk in OPN induction. This implies that OPN regulation by TLR signaling is critical in shaping inflammatory responses and may modulate IL‐17 production in response to pathogens.
Chromosomes and causation of human cancer and leukemia. XI. Correlation of karyotypes with clinical features of acute myeloblastic leukemia

Acute myeloblastic leukemia (AML) patients with chromosomal abnormalities in their bone marrow cells were divided into those with minor karyotypic abnormalities (MIKA) and those with major karyotypic abnormalities (MAKA). One of the largest subgroups in the MIKA group was shown to have cytologic characteristics typical of so‐called “classical” AML and a “prototypic” karyotype, which has been shown to be due to translocation between chromosomes #8 and #21. A missing Y chromosome in AML was mostly associated with this karyotype. Patients of the MAKA group were usually erythroleukemic, had no or very few normal metaphases among the abnormal ones in the marrow, and almost invariably showed karyotypic instability. Karyotypic differences did not affect the patients' survival after the initiation of chemotherapy as much as did the presence or absence of normal metaphases. However, the karyotypes do appear to be relevant to the decision as to whether a patient should be administered chemotherapy when no normal metaphases are found on the initial bone marrow examination.
Percutaneous Implanted Paddle Lead for Spinal Cord Stimulation: Technical Considerations and Long‐Term Follow‐Up

Objectives: Spinal cord stimulation (SCS) is an established method for treatment of chronic pain. Cylindrical‐type leads can be implanted percutaneously. In contrast, paddle leads (lamitrode) require more invasive surgery (i.e., laminotomy or laminectomy) for placement into the epidural space, thereby offering several advantages over percutaneous leads (octrode), including less lead migration and better paresthesia coverage. The goal of this study was to prospectively demonstrate the safety and efficacy of a percutaneous paddle lead for SCS.
Relationship between thermotolerance and hydrophobin‐like proteins in aerial conidia of Beauveria bassiana and Paecilomyces fumosoroseus as fungal biocontrol agents

Aims: This study was to illustrate the relationship between the thermotolerance and the contents of hydrophobin‐like or formic‐acid‐extractable (FAE) proteins in aerial conidia of Beauveria bassiana and Paecilomyces fumosoroseus produced on rice‐based substrate.
Affect and Decision Making in Troubled Information Technology Projects

Over the past two decades, several studies have investigated the factors that lead to and away from individuals’ reporting of truthful status information on IT projects. These studies have typically considered the reporting decisions of an individual who is aware of negative status information that is attributed to others’ errors. These previous studies have seldom examined the situation in which the individual is considering whether to report information about his or her own self-committed error on the project. In this study, we consider this largely unexamined phenomenon. In this context, we focus on the influences that different affective states and a personality trait (conscientiousness) can have on error reporting decisions. Specifically, we investigate how different moods (i.e., positive vs. negative) and conscientiousness can influence error reporting decisions in the context of an IT project. Based on the results from a controlled laboratory experiment, we find that individuals in a negative mood are more willing to report their errors compared to individuals in a positive mood. Conscientiousness also positively influences individuals’ willingness to report errors, and it also has an indirect effect through costbenefit differential (i.e., one’s perceptions of benefits relative to costs). Additionally, mood is found to moderate the relationship between conscientiousness and willingness to report. We discuss the implication of our findings and directions for future research and for practice.
The Role of Overlap and End State in Perceiving and Remembering Events

This work investigates how we organize complex, multiple and overlapping events. Two hypotheses have been proposed in investigating the cognitive principles that potentially constrain how humans construct event temporal relations. The end state bias hypothesis focuses on the end points of events. The overlap hypothesis focuses on whether events overlap or not in time. Participants viewed animations of fish swimming events at immediate versus delayed retention intervals, and judged temporal relations. Simulations manipulated the end states of events. The results consistently provided support for the overlap hypothesis, and the simulations suggested that there were vestiges of the end state in constructing event temporal relations.
Standardized Patient and Standardized Interdisciplinary Team Meeting: Validation of a New Performance‐Based Assessment Tool

The interdisciplinary team (IDT) approach is critical in the care of elderly adults. Performance‐based tools to assess IDT skills have not been well validated. A novel assessment tool, the standardized patient (SP) and standardized interdisciplinary team meeting (SIDTM), consisting of two stations, was developed. First, trainees evaluate a SP hospitalized after a fall. Second, trainees play the role of the physician in a standardized IDT meeting with a standardized registered nurse (SRN) and standardized medical social worker (SMSW) for discharge planning. The SP‐SIDTM was administered to 52 fourth‐year medical students (MS4s) and six geriatric medicine fellows (GMFs) in 2011/12. The SP, SRN, and SMSW scored trainee performance on dichotomous checklists of clinical tasks and Likert scales of communication skills, which were compared according to level of training using t‐tests. Trainees rated the SP‐SIDTM experience as moderately difficult, length of time about right, and believability moderate to high. Reliability was high for both cases (Cronbach α = 0.73–0.87). Interobserver correlation between SRN and SMSW checklist scores (correlation coefficient (r) = 0.82, P < . 001) and total scores (r = 0.69, P < .001) were high. The overall score on the SP‐SIDTM case was significantly higher for GMF (75) than for MS4 (65, P = .002). These observations support the validity of this novel assessment tool.
Motor control and sensory motor integration : issues and directions

INTRODUCTION. Motor control and sensory-motor integration (D.J. Glencross+). NEURAL CONTROL AND DISABILITIES OF SENSORY MOTOR INTEGRATION. Modeling the cerebellum: From adaptation to coordination (M.A. Arbib et al.). Interaction of the basal ganglia and supplementary motor area in the elaboration of movement (R. Iansek et al.). Motor control considerations for the rehabilitation of gait in Parkinson's Disease (M.E. Morris et al.). COMPUTATIONAL AND DYNAMIC MODELS OF MOTOR COORDINATION. Adaptive optimal control of human tracking (P.D. Neilson et al.). Testing dynamical and cognitive models of rhythmic pattern production (J. Pressing). Temporal coordination of human gait (B. Abernethy et al.). AQUISITION & DYNAMICS OF INTERLIMB COORDINATION. The contribution of spontaneous movements in the acquisition of motor coordination in infants (J.P. Piek). Going around in circles: The dynamics of bimanual circling (J.J. Summers et al.). Asymmetries in the dynamics of interlimb coordination (R.G. Carson et al.). Learning a dynamic limb synergy (N. O'Dwyer). KINAESTHETIC AND VISUO-MOTOR COORDINATION. Adaptation of arm movements to altered loads: Implications for sensorimotor transformations (G.K. Kerr, R.N. Marshall). The use of virtual environments in perception-action research: Grasping the impossible and controlling the improbable (J.P. Wann, S.K. Rushton). Trajectory modifications in response to superseding step stimuli (N.C. Barrett, R.T. Kane). Limiting motions in prehension (P.J. Bate, R. Hoffman). OVERVIEW AND FUTURE DIRECTIONS. Perspectives on motor control and sensory-motor integration (J.P. Piek, N.C. Barrett). INDEXES. Author index. Subject index.
Feature Learning for Activity Recognition in Ubiquitous Computing

Feature extraction for activity recognition in context-aware ubiquitous computing applications is usually a heuristic process, informed by underlying domain knowledge. Relying on such explicit knowledge is problematic when aiming to generalize across different application domains. We investigate the potential of recent machine learning methods for discovering universal features for context-aware applications of activity recognition. We also describe an alternative data representation based on the empirical cumulative distribution function of the raw data, which effectively abstracts from absolute values. Experiments on accelerometer data from four publicly available activity recognition datasets demonstrate the significant potential of our approach to address both contemporary activity recognition tasks and next generation problems such as skill assessment and the detection of novel activities.