Miracle-dz/UniFAR-FTUs huggingface dataset:
Recurrent Postural Vasovagal Syncope: Sympathetic Nervous System Phenotypes

Background— The pathophysiology of vasovagal syncope is poorly understood, and the treatment usually ineffective. Our clinical experience is that patients with vasovagal syncope fall into 2 groups, based on their supine systolic blood pressure, which is either normal (>100 mm Hg) or low (70–100 mm Hg). We investigated neural circulatory control in these 2 phenotypes. Methods and Results— Sympathetic nervous testing was at 3 levels: electric, measuring sympathetic nerve firing (microneurography); neurochemical, quantifying norepinephrine spillover to plasma; and cellular, with Western blot analysis of sympathetic nerve proteins. Testing was done during head-up tilt (HUT), simulating the gravitational stress of standing, in 18 healthy control subjects and 36 patients with vasovagal syncope, 15 with the low blood pressure phenotype and 21 with normal blood pressure. Microneurography and norepinephrine spillover increased significantly during HUT in healthy subjects. The microneurography response during HUT was normal in normal blood pressure and accentuated in low blood pressure phenotype (P=0.05). Norepinephrine spillover response was paradoxically subnormal during HUT in both patient groups (P=0.001), who thus exhibited disjunction between nerve firing and neurotransmitter release; this lowered norepinephrine availability, impairing the neural circulatory response. Subnormal norepinephrine spillover in low blood pressure phenotype was linked to low tyrosine hydroxylase (43.7% normal, P=0.001), rate-limiting in norepinephrine synthesis, and in normal blood pressure to increased levels of the norepinephrine transporter (135% normal, P=0.019), augmenting transmitter reuptake. Conclusions— Patients with recurrent vasovagal syncope, when phenotyped into 2 clinical groups based on their supine blood pressure, show unique sympathetic nervous system abnormalities. It is predicted that future therapy targeting the specific mechanisms identified in the present report should translate into more effective treatment.
Long-term memory motion-compensated prediction

Long-term memory motion-compensated prediction extends the spatial displacement vector utilized in block-based hybrid video coding by a variable time delay permitting the use of more frames than the previously decoded one for motion compensated prediction. The long-term memory covers several seconds of decoded frames at the encoder and decoder. The use of multiple frames for motion compensation in most cases provides significantly improved prediction gain. The variable time delay has to be transmitted as side information requiring an additional bit rate which may be prohibitive when the size of the long-term memory becomes too large. Therefore, me control the bit rate of the motion information by employing rate constrained motion estimation. Simulation results are obtained by integrating long-term memory prediction into an H.263 codec. Reconstruction PSNR improvements up to 2 dB for the Foreman sequence and 1.5 dB for the Mother-Daughter sequence are demonstrated in comparison to the TMN-2.0 H.263 coder. The PSNR improvements correspond to bit-rate savings up to 34 and 30%, respectively. Mathematical inequalities are used to speed up motion estimation while achieving full prediction gain.
Computational model of soft tissues in the human upper airway

This paper presents a three‐dimensional finite element model of the tongue and surrounding soft tissues with potential application to the study of sleep apnoea and of linguistics and speech therapy. The anatomical data was obtained from the Visible Human Project, and the underlying histological data was also extracted and incorporated into the model. Hyperelastic constitutive models were used to describe the material behaviour, and material incompressibility was accounted for. An active Hill three‐element muscle model was used to represent the muscular tissue of the tongue. The neural stimulus for each muscle group was determined through the use of a genetic algorithm‐based neural control model. The fundamental behaviour of the tongue under gravitational and breathing‐induced loading is investigated. It is demonstrated that, when a time‐dependent loading is applied to the tongue, the neural model is able to control the position of the tongue and produce a physiologically realistic response for the genioglossus. Copyright © 2012 John Wiley & Sons, Ltd.
Employee Ownership and Firm Disclosure

Evidence suggests that managers have an incentive to keep information opaque with the market when negotiating with employees who can extract above-market rents from the firm. We argue that employee ownership should mitigate this incentive to extract above-market rents and, in turn, alleviate the firm’s need to keep information opaque. Consistent with our expectations and using a number of proxies for disclosure, we find that firms whose non-manager employees have strong bargaining power provide less disclosure. However, this effect is mitigated, the greater the equity in company common stock held by non-manager employees. Our results suggest a novel capital market benefit to employee ownership. Specifically, employee ownership for non-manager employees appears to benefit the firm by not only aligning goals between the firm and its employees, but by also increasing disclosure from the firm to all of its stakeholders by mitigating the firm’s need to keep information opaque.
Anxiety disorder comobidity in Bipolar I Disorder: Relationship to depression severity and treatment outcome

The present study investigated the greater symptom severity and poorer treatment response found in patients with bipolar illness and anxiety comorbidity, and examined depression as a potential mediator of this relationship. The sample consisted of 92 patients in an acute episode of Bipolar I Disorder with a current or past history of an anxiety disorder. Diagnoses were based on structured clinical interview, and participants were assessed at pre‐treatment and then randomly assigned to pharmacotherapy alone or pharmacotherapy plus family intervention. Patients were assessed on a monthly basis by blind assessors over 28 months. Compared to patients without anxiety comorbidity, individuals with bipolar disorder and an anxiety disorder possessed greater current symptom severity, even after controlling for depression severity. Logistic regression analysis identified that being female and having higher current depression but not manic severity predicted comorbid anxiety. Comorbid anxiety was associated with poorer treatment response in the sample regardless of treatment type, particularly in subsequent depressive symptoms. Multiple regression analyses indicated that current depression but not manic severity partially mediated the relationship between comorbid anxiety and treatment outcome. Results from the current study investigating comorbid anxiety disorders are consistent with past research limited to anxiety symptoms. Depression only partially accounted for the link between comorbid anxiety and greater symptom severity and poorer treatment response, and examination of other factors is warranted. Because of the clinical relevance of comorbid anxiety in severe affective disorders, treatments designed to specifically address both concerns are needed. Depression and Anxiety 21:71–77, 2005. © 2005 Wiley‐Liss, Inc.
Spike-Based Probabilistic Inference in Analog Graphical Models Using Interspike-Interval Coding

Temporal spike codes play a crucial role in neural information processing. In particular, there is strong experimental evidence that interspike intervals (ISIs) are used for stimulus representation in neural systems. However, very few algorithmic principles exploit the benefits of such temporal codes for probabilistic inference of stimuli or decisions. Here, we describe and rigorously prove the functional properties of a spike-based processor that uses ISI distributions to perform probabilistic inference. The abstract processor architecture serves as a building block for more concrete, neural implementations of the belief-propagation (BP) algorithm in arbitrary graphical models (e.g., Bayesian networks and factor graphs). The distributed nature of graphical models matches well with the architectural and functional constraints imposed by biology. In our model, ISI distributions represent the BP messages exchanged between factor nodes, leading to the interpretation of a single spike as a random sample that follows such a distribution. We verify the abstract processor model by numerical simulation in full graphs, and demonstrate that it can be applied even in the presence of analog variables. As a particular example, we also show results of a concrete, neural implementation of the processor, although in principle our approach is more flexible and allows different neurobiological interpretations. Furthermore, electrophysiological data from area LIP during behavioral experiments are assessed in light of ISI coding, leading to concrete testable, quantitative predictions and a more accurate description of these data compared to hitherto existing models.
A few new facts about the EKG sequence

The EKG sequence is defined as follows: a1 = 1, a2 = 2 and an is the smallest natural number satisfying gcd(an−1, an) > 1 not already in the sequence. The sequence was previously investigated by Lagarias, Rains and Sloane. In particular, we know that (an) is a permutation of the natural numbers and that the prime numbers appear in this sequence in an increasing order. Lagarias, Rains and Sloane performed many numerical experiments on the EKG sequence up to the 10 7 th term and came up with several interesting conjectures. This paper provides proofs for the core part of those conjectures. Namely, let (a ′ ) be the sequence (an) with all terms of the form p and 3p, for p prime, changed to 2p. First, we prove that for any odd prime an = p we have an−1 = 2p. Then we prove that limn→∞ a ′ n n = 1, i.e., we have an ∼ n except for the values of p and 3p for p prime: if an = p then an ∼ n , and if an = 3p then an ∼ 3n 2 .
Chromatic and luminance contrast sensitivities in asymptomatic carriers from a large Brazilian pedigree of 11778 Leber hereditary optic neuropathy.

PURPOSE To determine whether asymptomatic 11778 LHON carriers demonstrated impairments in (1) chromatic red/green (R/G) and blue/yellow (B/Y) contrast sensitivity functions (CSF) and in (2) luminance contrast sensitivity functions in the spatial CSF (SCSF) and temporal CSF (TCSF) domains. METHODS Twenty-five carriers (8 male, 17 female; 34.1 +/- 15.1 years of age) of homoplasmic 11778 LHON from the same well-described family and 30 age-matched controls (17 male, 13 female; 29.2 +/- 7.1 years of age) were tested in one eye, randomly selected. Of the 25 eyes tested, 18 had normal fundus, 5 had swelling and microangiopathy, and 2 had temporal pallor. The R/G and B/Y CSFs were obtained after equiluminance correction with bichromatic horizontal sinusoidal gratings at 0.3, 0.7, and 2 cycles per degree (cpd); the SCSFs were obtained with achromatic gratings at 0.3, 2, 6, and 12 cpd; and the TCSFs were obtained at 2, 10, 20, and 33 Hz with sinusoidal modulation of a 2.7 degrees field with a superimposed spatial Gabor function. RESULTS Differences between carriers and controls were statistically significant for all spatial frequencies of chromatic and luminance SCSFs, but not for the TCSFs. R/G equiluminance settings of carriers differed from those of controls (P < 0.001), requiring higher luminance in the green; B/Y equiluminance settings were not statistically different in carriers and controls. Fundus findings did not correlate with CS results. CONCLUSIONS Luminance and chromatic spatial CS losses that affected all tested spatial frequencies, are reported in LHON asymptomatic carriers with the mtDNA 11778 mutation. No losses were found in the temporal CSF. An intriguing finding is that the blue system is substantially spared in this LHON family. These represent subclinical visual impairments in otherwise asymptomatic LHON carriers.
Myocardial Revascularization in New York State: Variations in the PCI-to-CABG Ratio and Their Implications

Background During the past 2 decades, percutaneous coronary intervention (PCI) has increased dramatically compared with coronary artery bypass grafting (CABG) for patients with coronary artery disease. However, although the evidence available to all practitioners is similar, the relative distribution of PCI and CABG appears to differ among hospitals and regions. Methods and Results We reviewed the published data from the mandatory New York State Department of Health annual cardiac procedure reports issued from 1994 through 2008 to define trends in PCI and CABG utilization in New York and to compare the PCI/CABG ratios in the metropolitan area to the remainder of the State. During this 15-year interval, the procedure volume changes for CABG, for all cardiac surgeries, for non-CABG cardiac surgeries, and for PCI for New York State were −40%, −20%, +17.5%, and +253%, respectively; for the Manhattan programs, the changes were similar as follows: −61%, −23%, +14%, and +284%. The average PCI/CABG ratio in New York State increased from 1.12 in 1994 to 5.14 in 2008; however, in Manhattan, the average PCI/CABG ratio increased from 1.19 to 8.04 (2008 range: 3.78 to 16.2). The 2008 PCI/CABG ratios of the Manhattan programs were higher than the ratios for New York City programs outside Manhattan, in Long Island, in the northern counties contiguous to New York City, and in the rest of New York State; their averages were 5.84, 5.38, 3.31, and 3.24, respectively. In Manhattan, a patient had a 56% greater chance of receiving PCI than CABG as compared with the rest of New York State; in one Manhattan program, the likelihood was 215% higher. Conclusions There are substantial regional and statewide differences in the utilization of PCI versus CABG among cardiac centers in New York, possibly related to patient characteristics, physician biases, and hospital culture. Understanding these disparities may facilitate the selection of the most appropriate, effective, and evidence-based revascularization strategy. (J Am Heart Assoc. 2012;1:e001446 doi: 10.1161/JAHA.112.001446.)
The Effect of Alkaline Activator Ratio on the Compressive Strength of Fly Ash-Based Geopolymer Paste

Alkaline activation of fly ash is a particular procedure in which ash resulting from a power plant combined with a specific alkaline activator creates a solid material when dried at a certain temperature. In order to obtain desirable compressive strengths, the mix design of fly ash based geopolymer pastes should be explored comprehensively. To determine the preliminary compressive strength for fly ash based geopolymer paste using Romanian material source, various ratios of Na2SiO3 solution/ NaOH solution were produced, keeping the fly ash/alkaline activator ratio constant. All the mixes were then cured at 70 °C for 24 hours and tested at 2 and 7 days, respectively. The aim of this paper is to present the preliminary compressive strength results for producing fly ash based geopolymer paste using Romanian material sources, the effect of alkaline activators ratio on the compressive strength and studying the directions for future research.
Relationships among bleeding severity, health‐related quality of life, and platelet count in children with immune thrombocytopenic purpura

Important outcomes for children with immune thrombocytopenic purpura (ITP) include health‐related quality of life (HRQOL) and bleeding severity. A HRQOL instrument for children with ITP, the Kids' ITP Tools (KIT), was recently validated. Secondary analysis of the KIT database was performed to determine relationships among platelet count, bleeding severity and HRQOL. Bleeding severity grade correlated with platelet count in chronic ITP but not in acute ITP. Platelet count and bleeding severity failed to have any statistically significant correlations with the KIT scores. These findings suggest that relationships among outcome measures in children with ITP, using currently available instruments, remain poorly defined. Pediatr Blood Cancer 2009;53:652–654. © 2009 Wiley‐Liss, Inc.
Purification, characterization and nucleotide sequence of the periplasmic C4‐dicarboxylate‐binding protein (DctP) from Rhodobacter capsulatus

A periplasmic binding protein essential for high‐affinity transport of the C4‐dicarboxylates malate, succinate and fumarate across the cytoplasmic membrane of the purple photosynthetic bacterium Rhodobacter capsulatus has been purified to homogeneity and some of its ligand‐binding properties characterized. The protein was not produced in a Tn5 insertion mutant unable to transport C4‐dicarboxylates under aerobic conditions in the dark. Wild‐type DNA corresponding to the location of the transposon insertion site was subcloned and a 1.5kb section sequenced. A complete open reading frame of 999bp was identified that encoded a 333‐residue protein (DctP) with a molecular weight of 36 128 with a 26‐residue amino‐terminal signal peptide. The identity of this protein with the purified dicarboxylate‐binding protein and the position of the predicted signal peptide cleavage site was confirmed by N‐terminal sequencing. No significant homology with other proteins was detected in database searches. A GC‐rich region of dyad symmetry was located 7bp downstream of the dctP translational stop codon. This structure may be of significance in regulating the relative abundance of DctP and other dct gene products which comprise the high‐affinity dicarboxylate transport system in this bacterium.
Stuttered and fluent speech production: An ALE meta‐analysis of functional neuroimaging studies

This study reports an activation likelihood estimation (ALE) meta‐analysis of imaging studies of chronic developmental stuttering in adults. Two parallel meta‐analyses were carried out: (1) stuttered production in the stutterers; (2) fluent production in the control subjects. The control subjects' data replicated previous analyses of single‐word reading, identifying activation in primary motor cortex, premotor cortex, supplementary motor area, Rolandic operculum, lateral cerebellum, and auditory areas, among others. The stuttering subjects' analysis showed that similar brain areas are involved in stuttered speech as in fluent speech, but with some important differences. Motor areas were over‐activated in stuttering, including primary motor cortex, supplementary motor area, cingulate motor area, and cerebellar vermis. Frontal operculum, Rolandic operculum, and anterior insula showed anomalous right‐laterality in stutterers. Auditory activations, due to hearing one's own speech, were essentially undetectable in stutterers. The phenomenon of efference copy is proposed as a unifying account of the pattern activation revealed within this ALE meta‐analysis. This provides the basis for a stuttering system model that is testable and should help to advance the understanding and treatment of this disorder. Hum. Brain Mapp 25:105–117, 2005. © 2005 Wiley‐Liss, Inc.
Impact of fecal occult blood on obscure gastrointestinal bleeding: observational study.

AIM To elucidate the association between small bowel diseases (SBDs) and positive fecal occult blood test (FOBT) in patients with obscure gastrointestinal bleeding (OGIB). METHODS Between February 2008 and August 2013, 202 patients with OGIB who performed both capsule endoscopy (CE) and FOBT were enrolled (mean age; 63.6 ± 14.0 years, 118 males, 96 previous overt bleeding, 106 with occult bleeding). All patients underwent immunochemical FOBTs twice prior to CE. Three experienced endoscopists independently reviewed CE videos. All reviews and consensus meeting were conducted without any information on FOBT results. The prevalence of SBDs was compared between patients with positive and negative FOBT. RESULTS CE revealed SBDs in 72 patients (36%). FOBT was positive in 100 patients (50%) and negative in 102 (50%). The prevalence of SBDs was significantly higher in patients with positive FOBT than those with negative FOBT (46% vs 25%, P = 0.002). In particular, among patients with occult OGIB, the prevalence of SBDs was higher in positive FOBT group than negative FOBT group (45% vs 18%, P = 0.002). On the other hand, among patients with previous overt OGIB, there was no significant difference in the prevalence of SBDs between positive and negative FOBT group (47% vs 33%, P = 0.18). In disease specific analysis among patients with occult OGIB, the prevalence of ulcer and tumor were higher in positive FOBT group than negative FOBT group. In multivariate analysis, only positive FOBT was a predictive factors of SBDs in patients with OGIB (OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend was evident among patients with occult OGIB who underwent FOBT on the same day or a day before CE. The prevalence of SBDs in positive vs negative FOBT group were 54% vs 13% in patients with occult OGIB who underwent FOBT on the same day or the day before CE (P = 0.001), while there was no significant difference between positive and negative FOBT group in those who underwent FOBT two or more days before CE (43% vs 25%, P = 0.20). CONCLUSION The present study suggests that positive FOBT may be useful for predicting SBDs in patients with occult OGIB. Positive FOBT indicates higher likelihood of ulcers or tumors in patients with occult OGIB. Undergoing CE within a day after FOBT achieved a higher diagnostic yield for patients with occult OGIB.
Misidentification of mental health symptoms in presence of organic diseases and delirium during psychiatric liaison consulting

Abstract Objective: To identify predictors of misidentification of organic mental disorders and delirium in patients undergoing psychiatric liaison consultation. Methods: Data were collected at Santa Casa de São Paulo between July of 2009 and March of 2013. We included in our analysis all inpatients for whom the requesting service judged that a psychiatric consultation was required for a possible mental health condition. Outcomes of interest were the instances of misidentification where a condition was initially deemed to be of a psychiatric nature, whereas the final diagnosis by the liaison psychiatric team was of an organic disease or delirium. Our predictors were the clinical specialty of the requesting service, requester and patient characteristics. A series of generalised linear models were used to evaluate misidentification risks. Results: A total of 947 subjects met our inclusion criteria, 14.6% having a final liaison diagnosis of organic mental disorder and 8.1% of delirium. Older patients were significantly associated with increased risk of misidentification for both organic conditions (OR 3.01 – 95% CI 2.01, 4.5) and delirium (OR 3.92 – 2.4, 6.39). Conclusions: Educational interventions in general hospitals focused on preventing psychiatric misdiagnosis should target in-hospital services where patients tend to be older.