Miracle-dz/UniFAR-FTUs huggingface dataset:
A Methodology for Selecting Assembly Systems Feeding Policy

– Assembly systems require uninterrupted components' availability to feed workstations. This paper aims to propose a methodology to help managers in evaluating and selecting the most suitable policy for materials delivery to the shop floor. The analysis focuses on three basic policies, namely kitting, just in time kanban‐based continuous supply and line storage, even including class‐based hybrid policies. , – Descriptive models are developed to design components' delivery systems and to compute their performances. Empirical criteria are utilized to associate specific policies to components classes in order to implement customized hybrid line feeding policies. A case study is then included to exemplify the method application and to show its capabilities as a decision making tool. , – Hybrid feeding policies may be preferable to a single feeding policy common to all components. This is shown in a representative case study. However, in general there is a priori superior method and only a comparison of alternative feeding policies based on objective performance measures can determine the best approach in specific industrial applications. , – The methodology is aimed at preliminary sizing and selection of alternative line feeding systems in deterministic environments. It is not intended for detailed performance analysis of assembly systems. , – Production managers are given quantitative decision tools to properly select the components' delivery method at an early decision stage. This allows trade‐offs between alternatives to be explored in order to deploy customized feeding policies differentiated on components basis to better fit specific company requirements. , – The paper extends previous descriptive models for line feeding systems and includes the possibility of hybrid policies.
A crucial role for HVEM and BTLA in preventing intestinal inflammation

The interaction between the tumor necrosis factor (TNF) family member LIGHT and the TNF family receptor herpes virus entry mediator (HVEM) co-stimulates T cells and promotes inflammation. However, HVEM also triggers inhibitory signals by acting as a ligand that binds to B and T lymphocyte attenuator (BTLA), an immunoglobulin super family member. The contribution of HVEM interacting with these two binding partners in inflammatory processes remains unknown. In this study, we investigated the role of HVEM in the development of colitis induced by the transfer of CD4+CD45RBhigh T cells into recombination activating gene (Rag)−/− mice. Although the absence of HVEM on the donor T cells led to a slight decrease in pathogenesis, surprisingly, the absence of HVEM in the Rag−/− recipients led to the opposite effect, a dramatic acceleration of intestinal inflammation. Furthermore, the critical role of HVEM in preventing colitis acceleration mainly involved HVEM expression by radioresistant cells in the Rag−/− recipients interacting with BTLA. Our experiments emphasize the antiinflammatory role of HVEM and the importance of HVEM expression by innate immune cells in preventing runaway inflammation in the intestine.
REE mineralisation and metasomatic alteration in the Olserum metasediments

The Olserum mineralisation is situated in the metasediments of the Vastervik formation, which repre-sents the southernmost continental margin of the Svecokarelian Domain. After deposition between 1.88 – 1.85 Ga these sediments were subsided to a depth of about 10 km and intruded by a series of granitoid melts. The resulting HT/LP metamorphism, with a peak at upper amphibolite facies, transformed the sediments to quartzites, quartzitic gneiss and gneiss. REE mineral-rich magnetite bands and veins occur in the mica-rich quartzite and have been in-terpreted as former heavy mineral-rich alluvial beds that now form placer deposits. Infiltration of enriched hydrothermal fluids into the Vastervik metasediments resulted in assimilation of primary sedimentary minerals, extensive metasomatic alteration and the subsequent reprecipitation of enriched material. At Olserum this process resulted in the formation of REE-bearing, magnetite-rich biotite veins, with monazite and xenotime constituting the main REE-bearing minerals. Subsequent magmatism-associated fluid events resulted in extensive metasomatic alteration, including the enrichment/depletion of REE in monazite/xenotime and the forma-tion of secondary uranium minerals. Electron microprobe analysis suggests that efficient leaching and transport processes, as well as coupled/uncoupled substitution mechanisms, were integral in the alteration of monazite, xeno-time and uraninite. Textural evidence and chemical analysis suggests a close relationship between REE-bearing minerals and U-Th-minerals at Olserum. The close relationship was reflected in the electron microprobe analysis results in this study, with some monazite and xenotime showing significant U and/or Th concentrations and some U-minerals having substantial REE content. Based on electron microprobe dating of monazite and xenotime, metasomatic alteration at Olserum is interpreted to have been largely associated with intrusion of granites belonging to the 1.85-1.65 Ga Transscandinavian Igneous Belt (TIB), and in particular the 1.76-1.81 Ga Smaland granites. However observations also indicate a later thermal event, interpreted as being possibly associated with the 1.46-1.42 Ga Hallandian orogeny.
Extreme Thrombocytosis Presenting in Anti-Neutrophil Cytoplasmic Autoantibodies-Associated Crescentic Glomerulonephritis with Immune Complex Deposits: A Case Report

Introduction We describe a female patient with extreme reactive thrombocytosis (RT) in anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated crescentic glomerulonephritis (CGN) with immune complex deposits, which has never been reported before. Case Presentation A female adolescent with symptoms of oliguria and gross hematuresis had serious renal function impairment (crescent formation and immune complex deposits in renal pathology examination with positive serum ANCA) and extreme thrombocytosis. We made a diagnosis of CGN and RT. After treatment with Prednisone, Cyclophosphamide, and plasmapheresis, the symptoms of oliguria and gross hematuresis were relieved remarkably and the serum creatinine and platelet count declined significantly. Conclusions The diagnosis of thrombocytosis is not easy in all cases. The coexistence of ANCA and the immune complex in CGN may cause a severe inflammatory state, leading to extreme RT. The roles that the immune complex and ANCA play on the effect of the platelet count and function in CGN need further research.
A model for continuing pharmacy education.

OBJECTIVE To develop and implement a continuing pharmacy education (CPE) program at Kaiser Permanente Colorado (KPCO) DESIGN: To address the continuing education needs of its diverse pharmacy staff, an internal continuing pharmacy education (CPE) program was developed. The pharmacy department became an accredited provider by the Accreditation Council for Pharmacy Education (ACPE). Live, interactive, and evidence-based CPE programs, presented by highly qualified internal staff members, utilized videoconferencing and a Web-based learning management system. Cross-accreditation of medical and pharmacy educational programs was offered to KPCO staff members. ASSESSMENT Annual needs assessments were conducted to ensure the provision of relevant educational topics and to assess learning needs. To demonstrate outcomes of the CPE programs, 2 methods were utilized: objective effectiveness assessment and knowledge acquisition assessment. This program met the objectives for CPE activities a large majority of the time (usually over 90%), demonstrated statistically significant (p < 0.05) improvement in knowledge from before to after the CPE activity in 11 of 13 questions asked, and minimized the cost to acquire CPE credit for both the pharmacy department and its staff members. CONCLUSION The KPCO continuing pharmacy education program has developed a high quality and cost-favorable system that has resulted in significant improvements in attendee knowledge.
Constraints on the uptake of labeled palmitate by the heart. The barriers at the capillary and sarcolemmal surfaces and the control of intracellular sequestration.

While long chain free fatty acids (FFA) are known to be a major fuel of the mammalian myocardium, little is known about the processes which limit their uptake in the intact heart. Conventional biochemical techniques necessitate the destruction of membrane barriers which could be significant in vivo. Steady state extraction techniques yield information only on net extraction. The necessary information for the demonstration of rate-limiting steps can only be obtained by a technique that preserves the structure of the organ and yet is sensitive to processes with rate constants on the order of tenths of a second. The multiple indicator dilution technique is ideal for this type of investigation. Using a perfused in situ dog heart, we made simultaneous injections of I-albumin (intravascular reference), C-sucrose (capillary surface and interstitial space reference), and H-palmitate (a representative of the long chain free fatty acids) into the left coronary artery and collected samples rapidly from the coronary sinus. The activity of each isotope in the venous samples was divided by the activity per milliliter in the injection to give the outflow fraction per milliliter and plotted vs. time to give the normalized coronary sinus concentration-time curve for each tracer. The curves were analyzed by a two-barrier model, which includes both the constraints at the capillary and muscle cell surfaces and an irreversible sequestration reaction inside the myocyte for palmitate. The capillary permeability of palmitate was only 2to 3-fold greater than that for sucrose; the palmitate entered the myocyte, whereas the sucrose did not; and the intracellular sequestration of palmitate was found to take place at a rate inversely proportional to the arterial lactate concentration. Normally some palmitate returns to the interstitial space and capillary after entering the cell. Toxic doses of flavaspidic acid or dinitrophenol changed this. They caused virtually complete sequestration of all the palmitate that entered the cell. The data indicate that the capillary endothelium is a major barrier to the extraction of FFA, that the activity of the reaction catalyzed by long chain fatty acyl thiokinase is controlled by the blood lactate concentration, and that flavaspidic acid and the uncoupler dinitrophenol in some way accelerate FFA activation.
Two Improved Approaches to Fault Detection with Unknown Inputs

Abstract This paper addresses the fault detection problem based on H ∞ performance and L 2 -gain performance. Two improved approaches compared with the recent results (Wang et al., 2005, Ding et al., 2000) are presented. One uses the inverse transfer function and state space representation to consider the H ∞ performance. The other uses dilated matrix formulation to handle different Lyapunov matrices based on L 2 -gain performance. All these conditions can be efficiently solved by LMI techniques.
The Social Network of Contemporary Popular Musicians

In this paper, we analyze two social network datasets of contemporary musicians constructed from allmusic.com (AMG), a music and artists' information database: one is the collaboration network in which two musicians are connected if they have performed or produced an album together, and the other is the similarity network in which they are connected if they were musically similar according to the music experts. We find that, while both networks exhibit typical features of social networks such as high transitivity (clustering), we find that they differ significantly in some key network features such as the degree and the betweenness distributions. We believe that this highlights the fundamental differences in the construction mechanism (self-organized collaboration and human-perceived similarity) of the new networks.
Infection by Toxoplasma gondii Induces Amoeboid-Like Migration of Dendritic Cells in a Three-Dimensional Collagen Matrix

Toxoplasma gondii, an obligate intracellular parasite of humans and other warm-blooded vertebrates, invades a variety of cell types in the organism, including immune cells. Notably, dendritic cells (DCs) infected by T. gondii acquire a hypermigratory phenotype that potentiates parasite dissemination by a ‘Trojan horse’ type of mechanism in mice. Previous studies have demonstrated that, shortly after parasite invasion, infected DCs exhibit hypermotility in 2-dimensional confinements in vitro and enhanced transmigration in transwell systems. However, interstitial migration in vivo involves interactions with the extracellular matrix in a 3-dimensional (3D) space. We have developed a collagen matrix-based assay in a 96-well plate format that allows quantitative locomotion analyses of infected DCs in a 3D confinement over time. We report that active invasion of DCs by T. gondii tachyzoites induces enhanced migration of infected DCs in the collagen matrix. Parasites of genotype II induced superior DC migratory distances than type I parasites. Moreover, Toxoplasma-induced hypermigration of DCs was further potentiated in the presence of the CCR7 chemotactic cue CCL19. Blocking antibodies to integrins (CD11a, CD11b, CD18, CD29, CD49b) insignificantly affected migration of infected DCs in the 3D matrix, contrasting with their inhibitory effects on adhesion in 2D assays. Morphological analyses of infected DCs in the matrix were consistent with the acquisition of an amoeboid-like migratory phenotype. Altogether, the present data show that the Toxoplasma-induced hypermigratory phenotype in a 3D matrix is consistent with integrin-independent amoeboid DC migration with maintained responsiveness to chemotactic and chemokinetic cues. The data support the hypothesis that induction of amoeboid hypermigration and chemotaxis/chemokinesis in infected DCs potentiates the dissemination of T. gondii.
Mars global atmospheric oscillations - Annually synchronized, transient normal-mode oscillations and the triggering of global dust storms

Observation and analyses of the atmospheric pressure at the surface on Mars for several Martian years has led to the discovery of transient events in the daily pressure variations of an unusual nature. These events last only a few sols (Mars days), appear to repeat on an annual basis to within a few sols, appear to cover a large portion of the hemisphere on the same sol or at least within a few sols, occur in pairs with separations of 20 sols in some instances, are coincident with the annual pressure minimum (i.e., the maximum concentration of carbon dioxide in the southern hemisphere), and consist of spectral components near to, and sometimes identical in, frequency to the diurnal and semidiurnal harmonics. It is suggested that these events are Kelvin, normal-mode, transient, global oscillations. Examination of the initiation of the 1977A, 1977B, and 1982A global dust storms indicate that pseudo-diurnal and some-times pseudo-semidiurnal oscillations exist during the initiation phase and might be involved in triggering the global dust storms, possibly in conjunction with winds due to longer-period circulations. The diurnal harmonic disappears prior to the 1977B global dust storm and is replaced by an oscillation at 1.1 cycles/sol. If the lack of a classical diurnal tide indicates the suppression of convection, this might partially explain the slow growth of the 1977B storm. The daily average pressure during the transient season, which precedes the global dust storm season by almost one fourth of a year, exhibits a different behavior during the global dust storm years than during the nonglobal dust storm years. This implies that the global circulation must differ significantly in these cases and may be related to the presence or absence of global dust storms later in a given year. These analyses suggest that an almost diurnal and an almost semidiurnal, high-frequency global oscillation, different from the classical solar-driven tides, may be quite common on Mars.
Direct detection of wavelike spatial structure at the bottom of the F region and its role on the formation of equatorial plasma bubble

We present hitherto unrevealed wavelike spatial structures, as seen in the 630 nm airglow intensity using a scanning photometer, prior to the occurrence of equatorial plasma bubble (EPB). The dominant wavelengths in the spatial variation of airglow intensity have excellent correspondence with the spatial separations of periodic plume structures in the radar observations, and the amplitudes of the wave perturbations (6–12%) are significantly more than the commonly quoted 5% seed perturbation used in simulation studies. In contrast, no such airglow structure was observed on EPB free evening. Concurrent ionosonde observations made from the magnetic equator, although displayed satellite trace on some occasions, did not show one‐to‐one correspondence between the occurrence of satellite trace and EPB, a finding that is inconsistent with a recent suggestion that satellite trace can be used as a precursor of EPB occurrence. The new findings are discussed in the light of current understanding of the day‐to‐day variability in EPB including its prediction.
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: Leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma

Soft tissue sarcomas (STS) represent a diverse group of histologic subtypes with targetable molecular alterations, often treated as a single disease. Sunitinib malate is a multitargeted receptor tyrosine kinase inhibitor active in other solid tumors carrying similar alterations (i.e., imatinib mesylate‐refractory gastrointestinal stromal tumors). This single‐institution phase II study investigated the safety and efficacy of sunitinib malate in three common STS subtypes. Patients with documented unresectable or metastatic STS (liposarcoma, leiomyosarcoma and malignant fibrous histiocytoma [MFH]), measurable disease, and 3 or less prior lines of therapy were eligible. Treatment consisted of sunitinib malate, 50 mg daily, for 4 weeks every 6 weeks. Forty‐eight patients were enrolled, and 35% were heavily pretreated (≥2 prior lines of chemotherapy). The safety profile resembled previously known sunitinib malate toxicities. Median progression‐free and overall survivals for liposarcoma, leiomyosarcoma, and MFH were 3.9 and 18.6, 4.2 and 10.1 and 2.5 and 13.6 months, respectively. The 3‐month progression‐free rates in the untreated and pretreated (chemotherapy) patients with liposarcoma, leiomyosarcoma and MFH were 75% and 69.2%, 60%, and 62.5% and 25% and 44.4%, respectively. With the caveats that a minority of patients with potentially indolent or low‐grade disease could have been included and the small numbers, a 3‐month progression‐free rate of >40% suggests activity for sunitinib malate at least in liposarcomas and leiomyosarcomas. Thus, we believe that further investigation in these susceptible STS subtypes is warranted.
A Surrogate Assisted Approach for Single-Objective Bilevel Optimization

Bilevel optimization refers to a hierarchical problem in which optimization needs to be performed at two nested levels, namely the upper level and the lower level. The aim is to identify the optimum of the upper level problem, subject to optimality of the corresponding lower level problem. Several problems from the domain of engineering, logistics, economics, and transportation have inherent nested structure which requires them to be modeled as bilevel optimization problems. Bilevel optimization usually requires inordinate amount of function evaluations since a lower level search needs to be conducted for evaluating each upper level solution. The evaluations are especially high when the problems are not suited for exact techniques and evolutionary techniques are employed instead. Reducing this computational effort has been one of the key pursuits in this domain recently. However, the use of surrogate modeling to achieve this goal has so far been scarcely studied. In this paper, we present a surrogate assisted optimization approach toward addressing this research gap. The approach uses surrogates of multiple types in order to provide flexibility of approximating different types of functions more accurately. The algorithm is further strengthened through the use of selective re-evaluation of promising solutions and periodic nested local search. The performance of the proposed algorithm is presented on twenty five standard benchmark problems. The results are compared with a number of other established evolutionary and hybrid algorithms to demonstrate the efficacy of the proposed approach in obtaining competitive results using relatively fewer function evaluations.
Rate Region of the Quadratic Gaussian Two-Encoder Source-Coding Problem

We determine the rate region of the quadratic Gaussian two-encoder source-coding problem. This rate region is achieved by a simple architecture that separates the analog and digital aspects of the compression. Furthermore, this architecture requires higher rates to send a Gaussian source than it does to send any other source with the same covariance. Our techniques can also be used to determine the sum-rate of some generalizations of this classical problem. Our approach involves coupling the problem to a quadratic Gaussian ldquoCEO problem.rdquo
Central projections from cat suboccipital muscles: A study using transganglionic transport of horseradish peroxidase

Central projections of suboccipital muscle nerves were examined following exposure of cut peripheral nerves to the tracer horseradish peroxidase. Labelled fibers entered the Cl and C2 dorsal roots and accumulated in the dorsolateral part of the dorsal funiculus. Many labelled fibers entered the grey matter of Cl to C3 in ventrally directed bundles which passed medially to the base of the dorsal horn. No terminal labelling was apparent in superficial layers of the dorsal horn. However, labelled fibers ramified extensively throughout, medial parts of the intermediate laminae, in and around the central cervical nucleus. Labelled fibers also projected toward the ventral horn. In cats subjected to ventral root section at the time of peripheral nerve exposure, a modest distribution of reaction product was observed deep in the ventral horn. In cats which did not undergo ventral root section, anterograde projections in the ventral horn were obscured by the simultaneous retrograde filling of motoneurons both in the ventromedial nucleus and on the medial and lateral borders of the gray matter. Labelled axons also coursed rostrally into the medulla where they formed a circumscribed bundle between the main cuneate nucleus and the spinal nucleus of V. Three consistent regions of HRP deposition could be identified at medullary levels. Dense accumulations of reaction product were present in circumscribed regions of the external cuneate nucleus (ECN) throughout its rostrocaudal extent. A second zone of dense labelling occurred in the intermediate nucleus of Cajal, where it appeared to form a continuing column rostral to the central cervical nucleus in C1–C3. Sparse labelling was restricted to a third zone in the ventrolateral part of the main cuaeate nucleus.