Miracle-dz/UniFAR-FTUs huggingface dataset:
Associations between APOE polymorphisms and seven diseases with cognitive impairment including Alzheimer’s disease, frontotemporal dementia, and dementia with Lewy bodies in southeast China

Objective To explore the effect of APOE polymorphisms on patients with cognitive impairments in The Chinese Han population. Materials and methods A total of 1027 cases with Alzheimer’s disease (AD), 40 cases with vascular dementia (VaD), 28 cases with behavioral variant frontotemporal dementia (bvFTD), 54 cases with semantic dementia (SD), 44 cases with dementia with Lewy bodies (DLB), 583 cases with mild cognitive impairment (MCI), and 32 cases with vascular cognitive impairment no dementia (VCIND) were recruited consecutively from memory disorders clinics in Huashan Hospital between January 2010 and December 2014. The 1149 cognitively normal controls were recruited from the community epidemiologic investigations. The APOE genotypes were determined using the TaqMan assay. Results The distribution of genotype and allele frequencies of APOE differed significantly between control and AD or MCI, with &egr;4 increasing the risk of AD and MCI in a dose-dependent pattern and &egr;2 decreasing the risk of AD, but not the risk of MCI. As for VaD, significant differences in the APOE genotype distribution were found compared with the controls. E4/4 increased the risk of VaD and &egr;4 increased the risk of VCIND in women. The allele distribution differed between bvFTD and controls, but genotype and allele frequencies of APOE did not affect the risk of bvFTD, SD, and DLB. Conclusion In The Chinese Han population, APOE &egr;4 increased the risk of AD and MCI in a dose-dependent manner and &egr;2 decreased the risk of AD as reported previously. APOE &egr;4 might increase risk in VaD and female patients with VCIND, but no effects of APOE on bvFTD, DLB, and SD were found.
Social network analysis of mating patterns in American black bears (Ursus americanus)

Nonrandom mating can structure populations and has important implications for population‐level processes. Investigating how and why mating deviates from random is important for understanding evolutionary processes as well as informing conservation and management. Prior to the implementation of parentage analyses, understanding mating patterns in solitary, elusive species like bears was virtually impossible. Here, we capitalize on a long‐term genetic data set collected from black bears (Ursus americanus) (N = 2422) in the Northern Lower Peninsula (NLP) of Michigan, USA. We identified mated pairs using parentage analysis and applied logistic regression (selection) models that controlled for features of the social network, to quantify the effects of individual characteristics, and spatial and population demographic factors on mating dynamics. Logistic regression models revealed that black bear mating was associated with spatial proximity of mates, male age, the time a pair had coexisted, local population density and relatedness. Mated pairs were more likely to contain older males. On average, bears tended to mate with nearby individuals to whom they were related, which does not support the existence of kin recognition in black bears. Pairwise relatedness was especially high for mated pairs containing young males. Restricted dispersal and high male turnover from intensive harvest mortality of NLP black bears are probably the underlying factors associated with younger male bears mating more often with female relatives. Our findings illustrate how harvest has the potential to disrupt the social structure of game species, which warrants further attention for conservation and management.
Multi-Sided Platforms

We study the economic tradeoffs that drive organizations to position themselves closer to or further away from a multi-sided platform (MSP) business model, relative to three traditional alternatives: vertically integrated firms, resellers or input suppliers. These tradeoffs lead to a comprehensive discussion of the defining features of MSPs. The formal model we develop focuses on the MSP versus vertical integration choice, which we interpret in the context of professional services. A key tradeoff emerges between the need to coordinate decisions that generate spillovers across professionals (best achieved by a vertical integrated firm) and the need to both motivate unobservable effort by professionals and ensure professionals adapt their decisions to their private information (best achieved by a MSP). We show how this baseline tradeoff is impacted by the nature of contracts available to the vertically integrated firm and the MSP, and by the possibility of professionals holding pessimistic expectations when deciding whether or not to join the vertically integrated firm or MSP.
Disruption of Lipid Raft Function Increases Expression and Secretion of Monocyte Chemoattractant Protein-1 in 3T3-L1 Adipocytes

The adipocyte is unique in its capacity to store lipids. In addition to triglycerides, the adipocyte stores a significant amount of cholesterol. Moreover, obese adipocytes are characterized by a redistribution of cholesterol with depleted cholesterol in the plasma membrane, suggesting that cholesterol perturbation may play a role in adipocyte dysfunction. We used methyl-β-cyclodextrin (MβCD), a molecule with high affinity for cholesterol, to rapidly deplete cholesterol level in differentiated 3T3-L1 adipocytes. We tested whether this perturbation altered adipocyte secretion of monocyte chemoattractant protein-1 (MCP-1), a chemokine that is elevated in obesity and is linked to obesity-associated chronic diseases. Depletion of cholesterol by MβCD increased MCP-1 secretion as well as the mRNA and protein levels, suggesting perturbation at biosynthesis and secretion. Pharmacological inhibition revealed that NF-κB, but not MEK, p38 and JNK, was involved in MβCD-stimulated MCP-1 biosynthesis and secretion in adipocytes. Finally, another cholesterol-binding drug, filipin, also induced MCP-1 secretion without altering membrane cholesterol level. Interestingly, both MβCD and filipin disturbed the integrity of lipid rafts, the membrane microdomains enriched in cholesterol. Thus, the depletion of membrane cholesterol in obese adipocytes may result in dysfunction of lipid rafts, leading to the elevation of proinflammatory signaling and MCP-1 secretion in adipocytes.
The Five AhMTP1 Zinc Transporters Undergo Different Evolutionary Fates towards Adaptive Evolution to Zinc Tolerance in Arabidopsis halleri

Gene duplication is a major mechanism facilitating adaptation to changing environments. From recent genomic analyses, the acquisition of zinc hypertolerance and hyperaccumulation characters discriminating Arabidopsis halleri from its zinc sensitive/non-accumulator closest relatives Arabidopsis lyrata and Arabidopsis thaliana was proposed to rely on duplication of genes controlling zinc transport or zinc tolerance. Metal Tolerance Protein 1 (MTP1) is one of these genes. It encodes a Zn2+/H+ antiporter involved in cytoplasmic zinc detoxification and thus in zinc tolerance. MTP1 was proposed to be triplicated in A. halleri, while it is present in single copy in A. thaliana and A. lyrata. Two of the three AhMTP1 paralogues were shown to co-segregate with zinc tolerance in a BC1 progeny from a cross between A. halleri and A. lyrata. In this work, the MTP1 family was characterized at both the genomic and functional levels in A. halleri. Five MTP1 paralogues were found to be present in A. halleri, AhMTP1-A1, -A2, -B, -C, and -D. Interestingly, one of the two newly identified AhMTP1 paralogues was not fixed at least in one A. halleri population. All MTP1s were expressed, but transcript accumulation of the paralogues co-segregating with zinc tolerance in the A. halleri X A. lyrata BC1 progeny was markedly higher than that of the other paralogues. All MTP1s displayed the ability to functionally complement a Saccharomyces cerevisiæ zinc hypersensitive mutant. However, the paralogue showing the least complementation of the yeast mutant phenotype was one of the paralogues co-segregating with zinc tolerance. From our results, the hypothesis that pentaplication of MTP1 could be a major basis of the zinc tolerance character in A. halleri is strongly counter-balanced by the fact that members of the MTP1 family are likely to experience different evolutionary fates, some of which not concurring to increase zinc tolerance.
Size estimation of non-cooperative data collections

With the increasing amount of data in deep web sources (hidden from general search engines behind web forms), accessing this data has gained more attention. In the algorithms applied for this purpose, it is the knowledge of a data source size that enables the algorithms to make accurate decisions in stopping the crawling or sampling processes which can be so costly in some cases [14]. This tendency to know the sizes of data sources is increased by the competition among businesses on the Web in which the data coverage is critical. In the context of quality assessment of search engines [7], search engine selection in the federated search engines, and in the resource/collection selection in the distributed search field [19], this information is also helpful. In addition, it can give an insight over some useful statistics for public sectors like governments. In any of these mentioned scenarios, in the case of facing a non-cooperative collection which does not publish its information, the size has to be estimated [17]. In this paper, the suggested approaches for this purpose in the literature are categorized and reviewed. The most recent approaches are implemented and compared in a real environment. Finally, four methods based on the modification of the available techniques are introduced and evaluated. In one of the modifications, the estimations from other approaches could be improved ranging from 35 to 65 percent.
How commonly is upper gastrointestinal cancer missed at endoscopy? A meta-analysis

Background and study aims: Upper gastrointestinal (UGI) cancer in the Western world usually presents at an advanced stage, when opportunities for curative therapy are limited. The failure to detect subtle, early-stage UGI cancer at endoscopy may contribute to a poor prognosis. We undertook a meta-analysis of studies of endoscopic miss rates for UGI cancer to quantify how often opportunities to diagnose cancer at an earlier stage are missed. Patients and methods: A MEDLINE search was conducted to identify relevant studies, and a meta-analysis was conducted. “Missed” UGI cancer was defined as cancer that had not been diagnosed by UGI endoscopy performed within 3 years before the diagnosis. Random effects meta-analysis was used to determine the event rate of missed UGI cancer. Results: Ten studies were identified that included 3,787 patients with UGI cancer. Four hundred eighty-seven UGI cancers were missed at endoscopy within 3 years before diagnosis. Marked heterogeneity was observed between studies (I 2, 94.4 %; P < 0.001). On random effects meta-analysis, the pooled miss rates were 6.4 % (95 % confidence interval [CI], 4.3 % – 9.5 %) within 1 year and 11.3 % (95 % CI, 7.5 % – 16.6 %) within 3 years before diagnosis. There appeared to be no difference between the miss rates of oesophageal (44 %) and gastric (51 %) cancer (P = 0.42). Conclusion It appears that 11.3 % of UGI cancers are missed at endoscopy up to 3 years before diagnosis. To ameliorate the poor prognosis of patients with UGI cancer in the Western world, efforts should be made to improve the quality of UGI endoscopy and create opportunities for earlier diagnosis.
Ocular Morphology of the Leatherback Sea Turtle ( Dermochelys Coriacea )

Objective The Leatherback sea turtle is the largest extant reptile and the sole member of the family Dermochelyidae. Here, the eye of this critically endangered marine turtle was investigated to determine the anatomy, optics, and optical sensitivity. Animals studied Three Leatherback sea turtles, Dermochelys coriacea. Results The eye is small in proportion to body size of the adult compared to other vertebrates, with prominence of the retractor bulbi and pyramidalis muscles. The nictitans shows extensive folding of the bulbar conjunctiva as an apparent mechanism to increase the surface area for mucus secretion. The intraocular anatomy is consistent with an eye adapted to aquatic vision with minimal curvature of the cornea, a near-spherical lens, deep ciliary cleft and highly vascularized ciliary body. The optical sensitivity, a measure of the sensitivity to light of a given optical system, is higher than in other marine turtles studied but lower than those found in teleost fish that share a habitat with the Leatherback sea turtle. Conclusions The Leatherback sea turtle shows ocular features that are characteristic of Chelonians with similarities to aquatic mammals. The calculated optical sensitivity suggests that compared to pelagic fishes, for instance, the Leatherback sea turtle eye is not particularly well adapted for vision in dim light even though this species is known to venture into deep, dark waters, and might feed at night.
A case study of environmental factors influencing teaching assistant job satisfaction

Teaching assistants (TAs) play an integral role in teaching computer science undergraduates in North America. We report lessons in lab TA management, based on a case study which identified environmental factors affecting TAs' job satisfaction. These factors were identified through a series of semi-structured interviews about 23 lab sections taught at the University of British Columbia. We corroborated this with observational sampling of eight different TAs. Identified physical factors affecting job satisfaction include the layout and lighting of the lab rooms. Temporal factors include the intensity and length of the lab sessions. Having a positive social environment (in particular, support from team teaching and staff meetings) was also found to improve job satisfaction.
Instructional Efficiency of the Integration of Graphing Calculators in Teaching and Learning Mathematics.

This quasi-experimental study with non-equivalent control group post-test only design was conducted to investigate the effects of using graphing calculators in mathematics teaching and learning on Form Four Malaysian secondary school students’ performance and their meta-cognitive awareness level. Graphing calculator strategy refers to the use of TI-83 Plus graphing calculator in teaching and learning of Straight Lines topic. The experimental group underwent learning using graphing calculator while the control group underwent learning using conventional instruction. Three instruments were used in this study namely, Straight Lines Achievement Test, Paas Mental Effort Rating Scale and Metacognitive Awareness Survey. The data were analysed using independent t-test and planned comparison test. The findings indicated that the graphing calculators’ instruction enhanced students’ performance and induced higher levels of metacognitive awareness among students. Less mental effort were invested during the learning and test phases and hence increased 3-dimensional instructional efficiency index in learning of Straight Lines topic. Hence it can be implied that integrating the use of graphing calculators in teaching and learning of mathematics was more efficient than the conventional instruction strategy. Even though some students experience difficulties in using graphing calculators initially during learning, they responded overwhelmingly that graphing calculators improves their understanding of the Straight Lines topic. Hence, the usage of the graphing calculator lends as an effective strategy in teaching and learning of mathematics.
Fusimotor control of spindle sensitivity regulates central and peripheral coding of joint angles

Proprioceptive afferents from muscle spindles encode information about peripheral joint movements for the central nervous system (CNS). The sensitivity of muscle spindle is nonlinearly dependent on the activation of gamma (γ) motoneurons in the spinal cord that receives inputs from the motor cortex. How fusimotor control of spindle sensitivity affects proprioceptive coding of joint position is not clear. Furthermore, what information is carried in the fusimotor signal from the motor cortex to the muscle spindle is largely unknown. In this study, we addressed the issue of communication between the central and peripheral sensorimotor systems using a computational approach based on the virtual arm (VA) model. In simulation experiments within the operational range of joint movements, the gamma static commands (γs) to the spindles of both mono-articular and bi-articular muscles were hypothesized (1) to remain constant, (2) to be modulated with joint angles linearly, and (3) to be modulated with joint angles nonlinearly. Simulation results revealed a nonlinear landscape of Ia afferent with respect to both γs activation and joint angle. Among the three hypotheses, the constant and linear strategies did not yield Ia responses that matched the experimental data, and therefore, were rejected as plausible strategies of spindle sensitivity control. However, if γs commands were quadratically modulated with joint angles, a robust linear relation between Ia afferents and joint angles could be obtained in both mono-articular and bi-articular muscles. With the quadratic strategy of spindle sensitivity control, γs commands may serve as the CNS outputs that inform the periphery of central coding of joint angles. The results suggest that the information of joint angles may be communicated between the CNS and muscles via the descending γs efferent and Ia afferent signals.
a powerful and independent prognostic indicator in chronic myeloid leukemia

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Towards a Learning Society — Exploring the Challenge of Applied Information Literacy through Reality-Based Scenarios

Abstract This paper outlines the role of information use in society to illustrate the process of developing a learning society as envisaged by the Information Literacy Research Centre which is located within the Linköping University Library. The section on the theoretical framework discusses learning from different pedagogical perspectives, the importance of reality-based scenarios and also proposes a new model, which could be described as an extension of the well known and often cited Kuhlthau’s Information Search Process (ISP) model. The successful implementation of this new model, Applied Information Literacy Education, is explored through the outlines of the following courses, Civic and Public Communication - the Citizen in the Information Society, and, Health Promoting Organizations. The paper concludes by reflecting on the theoretical and practical implications of applying the extended Kuhlthau’s model, as practice has shown that this approach is useful for pedagogical developmental work, including curriculum development in general, and specifically for information literacy programmes. This is presented as a necessary step for the promotion of a learning society based on information literacy and as a challenge not just for information literacy educators, but for other educators as well.
A Practical Guide to Wavelet Analysis.

A practical step-by-step guide to wavelet analysis is given, with examples taken from time series of the El Nino–Southern Oscillation (ENSO). The guide includes a comparison to the windowed Fourier transform, the choice of an appropriate wavelet basis function, edge effects due to finite-length time series, and the relationship between wavelet scale and Fourier frequency. New statistical significance tests for wavelet power spectra are developed by deriving theoretical wavelet spectra for white and red noise processes and using these to establish significance levels and confidence intervals. It is shown that smoothing in time or scale can be used to increase the confidence of the wavelet spectrum. Empirical formulas are given for the effect of smoothing on significance levels and confidence intervals. Extensions to wavelet analysis such as filtering, the power Hovmoller, cross-wavelet spectra, and coherence are described. The statistical significance tests are used to give a quantitative measure of change.
Configuration selection using code change impact analysis for regression testing

Configurable systems that let users customize system behaviors are becoming increasingly prevalent. Testing a configurable system with all possible configurations is very expensive and often impractical. For a single version of a configurable system, sampling approaches exist that select a subset of configurations from the full configuration space for testing. However, when a configurable system changes and evolves, existing approaches for regression testing select all configurations that are used to test the old versions for testing the new version. As demonstrated in our experiments, this retest-all approach for regression testing configurable systems turns out to be highly redundant. To address this redundancy, we propose a configuration selection approach for regression testing. Formally, given two versions of a configurable system, S (old) and S' (new), and given a set of configurations CS for testing S, our approach selects a subset CS' of CS for regression testing S'. Our study results on two open source systems and a large industrial system show that, compared to the retest-all approach, our approach discards 15% to 60% of configurations as redundant. Our approach also saves 20% to 55% of the regression testing time, while retaining the same fault detection capability and code coverage of the retest-all approach.
Between Anger and Engagement: Donald Trump and Black America

Abstract History suggests that social movements for change are often met with powerful counter-movements. Relying upon movement counter-movement dynamics, this paper examines whether or not contemporary reactionary conservatism—in this case Donald Trump's candidacy in 2016, offers an opportunity for African-American mobilization. Today, the reactionary right presents a threat to racial progress and the black community as it has grown from direct opposition to the election of President Obama, immigration reform, and gay and lesbian rights. With conditions ripe for a movement in response to the right, we examine the mobilizing effect on African-Americans of the threatening political context symbolized by Donald Trump. If African-Americans are to retain political relevance beyond the Obama era, then black turnout will need to reach rates similar to the historic 2008 election. Using the 2016 Black Voter Project (BVP) Pilot Study, we explore African-American political engagement in the 2016 election, a time void of President Obama as a mobilizing figure. We find that African-Americans who hold strong negative opinions of Trump in 2016 voted at rates similar to the historical turnout of 2008, offering a possible strategy to mobilize blacks beyond Obama's presidency. Moreover, the threat that Trump represents significantly drives blacks to engage in politics beyond voting even after accounting for alternative explanations. In the end, Trump and the reactionary movement behind him offers a powerful mobilizing force for an African-American population that can no longer look toward the top of the Presidential ticket for inspiration.