Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward a Reliable Chipless RFID Humidity Sensor Tag Based on Silicon Nanowires

This paper presents a chipless radio frequency identification (RFID) sensor tag having both identification and sensing capabilities. It is based on one resonant scatterer operating as a signal processing antenna in the 3-7.5 GHz band. The scatterer is used to monitor a physical parameter variation, as well as to identify the remote sensor. To make a resonator sensitive to the humidity, silicon nanowires are deposited on the tag surface using a simple process. The tag needs only one conductive layer so that it can be directly printed on the product to sense and to identify. Measurements done using a bistatic radar configuration in the frequency domain validate this concept. To demonstrate the reliability of such an application, two chipless RFID sensors placed in various environments are simultaneously detected using an anticollision technique based on spectral separation.
A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension.

BACKGROUND Primary pulmonary hypertension is a progressive disease for which no treatment has been shown in a prospective, randomized trial to improve survival. METHODS We conducted a 12-week prospective, randomized, multicenter open trial comparing the effects of the continuous intravenous infusion of epoprostenol (formerly called prostacyclin) plus conventional therapy with those of conventional therapy alone in 81 patients with severe primary pulmonary hypertension (New York Heart Association functional class III or IV). RESULTS Exercise capacity was improved in the 41 patients treated with epoprostenol (median distance walked in six minutes, 362 m at 12 weeks vs. 315 m at base line), but it decreased in the 40 patients treated with conventional therapy alone (204 m at 12 weeks vs. 270 m at base line; P < 0.002 for the comparison of the treatment groups). Indexes of the quality of life were improved only in the epoprostenol group (P < 0.01). Hemodynamics improved at 12 weeks in the epoprostenol-treated patients. The changes in mean pulmonary-artery pressure for the epoprostenol and control groups were -8 percent and +3 percent, respectively (difference in mean change, -6.7 mm Hg; 95 percent confidence interval, -10.7 to -2.6 mm Hg; P < 0.002), and the mean changes in pulmonary vascular resistance for the epoprostenol and control groups were -21 percent and +9 percent, respectively (difference in mean change, -4.9 mm Hg/liter/min; 95 percent confidence interval, -7.6 to -2.3 mm Hg/liter/min; P < 0.001). Eight patients died during the study, all of whom had been randomly assigned to conventional therapy (P = 0.003). Serious complications included four episodes of catheter-related sepsis and one thrombotic event. CONCLUSIONS As compared with conventional therapy, the continuous intravenous infusion of epoprostenol produced symptomatic and hemodynamic improvement, as well as improved survival in patients with severe primary pulmonary hypertension.
A polymorphism in the oestrogen receptor gene explains covariance between digit ratio and mating behaviour

In vertebrates, including humans, the relative length of the second to the fourth digit correlates with sex hormone-dependent behavioural, psychological and physiological traits. However, despite a decade of research, the underlying mechanism linking digit ratio to these sex hormone-dependent traits remains unclear. Previous work suggests that during embryo development, circulating levels of plasma androgens or oestrogens may act through their receptors to affect transcription levels of posterior HOX genes in the developing digits, thereby possibly influencing their relative length. The correlation between digit ratio and sex hormone-dependent traits might thus stem from variation in expression or sensitivity of the sex hormone receptors, or from variation in sex hormone levels in the embryo. Here, we show that in a population of 1156 zebra finches Taeniopygia guttata, a polymorphism in the oestrogen receptor α gene (ESR1) explains 11.3 per cent of the variation in digit ratio, and is also associated with male and female-mating behaviour. By contrast, we found no associations between digit ratio or mating behaviours and polymorphisms in the androgen receptor gene. Thus, our results (i) provide an explanation for the observed significant genetic covariance between digit ratio and male and female mating behaviour and (ii) strongly confirm the indicator function of digit ratio through the oestrogen pathway. Finally, we note that the commonly invoked effect of foetal testosterone on human digit ratio seems to be substantially weaker than the effect described here.
Self-rated health and standard risk factors for myocardial infarction: a cohort study

Objective To investigate the relationship between self-rated health, adjusted for standard risk factors, and myocardial infarction. Design Population-based prospective cohort study. Setting Enrolment took place between 1990 and 2004 in Västerbotten County, Sweden Participants Every year, persons in the total population, aged 40, 50 or 60 were invited. Participation rate was 60%. The cohort consisted of 75 386 men and women. After exclusion for stroke or myocardial infarction before, or within 12 months after enrolment or death within 12 months after enrolment, 72 530 persons remained for analysis. Mean follow-up time was 13.2 years. Outcome measures Cox regression analysis was used to estimate HRs for the end point of first non-fatal or fatal myocardial infarction. HR were adjusted for age, sex, systolic blood pressure, total cholesterol, smoking, diabetes, body mass index, education, physical activity and self-rated health in the categories very good; pretty good; somewhat good; pretty poor or poor. Results In the cohort, 2062 persons were diagnosed with fatal or non-fatal myocardial infarction. Poor self-rated health adjusted for sex and age was associated with the outcome with HR 2.03 (95% CI 1.45 to 2.84). All categories of self-rated health worse than very good were statistically significant and showed a dose–response relationship. In a multivariable analysis with standard risk factors (not including physical activity and education) HR was attenuated to 1.61 (95% CI 1.13 to 2.31) for poor self-rated health. All categories of self-rated health remained statistically significant. We found no interaction between self-rated health and standard risk factors except for poor self-rated health and diabetes. Conclusions This study supports the use of self-rated health as a standard risk factor among others for myocardial infarction. It remains to demonstrate whether self-rated health adds predictive value for myocardial infarction in combined algorithms with standard risk factors.
Linear Differential Operators for Polynomial Equations

Given a squarefree polynomial P? k0x,y ], k0a number field, we construct a linear differential operator that allows one to calculate the genus of the complex curve defined by P= 0 (when P is absolutely irreducible), the absolute factorization of P over the algebraic closure of k0, and calculate information concerning the Galois group of P over ___ k0(x) as well as overk0 (x).
Phase Unwrapping Using Interlaced Fringes for Phase-Shifting Techniques

A novel phase-unwrapping algorithm is proposed by using interlaced fringe in optical 3-D measurement. In the measurement, a four-step phase-shift method including four sinusoidal fringes with 90° phase shift is used. On top of these four fringes, an interlaced fringe is encoded. In the measurement, all these designed fringes are projected onto the tested object, and fringe images are acquired by charge-coupled device cameras. Then, four fringe-different images with zero-valued fringes can be obtained by subtracting the interlaced fringe image from the other four sinusoidal fringe images; thus, the position and the characteristic of each fringe can be distinguished. Combined with the composition of the encoding interlaced fringe, the order of the fringes can be obtained. The whole process needs only one assistant interlaced fringe image. Experiment result shows that the proposed algorithm can get the 3-D information rapidly and exactly and has more robustness.
Regeneration in a Degenerating Brain: Potential of Allopregnanolone as a Neuroregenerative Agent

Confronting the efficacy of a regenerative therapeutic is the degenerative environment that is characterized by neuronal loss, physical plague and glial scar barriers and inflammation. But perhaps more fundamental from a regenerative perspective, are changes in the biochemical milieu of steroid and peptide growth factors, cytokines and neurotransmitter systems. Data from multiple levels of analysis indicate that gonadal steroid hormones and their metabolites can promote neural health whereas their decline or absence are associated with decline in neural health and increased risk of neurodegenerative disease including Alzheimer’s. Among the steroids in decline, is allopregnanolone (APα), a neurosteroid metabolite of progesterone, which was found to be reduced in the serum [1,2] and plasma [3] and brain of aged vs. young subjects [4]. Further, Alzheimer disease (AD) victims showed an even further reduction in plasma and brain levels of APα relative to age-matched neurologically normal controls [1,4,5]. Our earlier work has shown that APα is a neurogenic agent for rodent hippocampal neural progenitors and for human neural progenitor cells derived from the cerebral cortex [6]. Our ongoing research seeks to determine the neurogenic potential of APα in the triple transgenic mouse model of Alzheimer’s disease (3xTgAD) as AD related pathology progresses from imperceptible to mild to severe. Initial analyses suggest that neurogenic potential changes with age in nontransgenic mice and that the neurogenic profile differs between non-transgenic and 3xTgAD mice. Comparative analyses indicate that APα modifies neurogenesis in both non-transgenic and 3xTgAD mice. Preliminary data suggest that APα may modify Alzheimer’s pathology progression. Together the data indicate that APα may maintain the regenerative ability of the brain and modify progression of AD related pathology. Challenges for efficacy of regenerative agents within a degenerative milieu are discussed.
Assessment of Social Participation in Three Measurement Times in Children with Traumatic Brain Injuries (TBI) Based on Parental Perceptions

Purpose: The aim of this study was to measure social participation in children with traumatic brain injuries (TBI) on their parental perceptions, retrospectively for the pre-injury period, at the beginning of rehabilitation and one year after return to school. Methods: This study was conducted among 17 children aged 5 to 17 years old with moderate or severe TBI and their parents. Social participation was assessed using the LIFE-H for Children (1.0). Results: A significant decrease (p ≤ 0.001) in the level of accomplishment of life habits was found for all categories between the measurements taken pre-injury and at the beginning of rehabilitation. Significant differences (p ≤ 0.002) related to the increase in the life habit accomplishment scores were also found between measurements taken at the beginning of rehabilitation and one year after return to school. Conclusion: TBI significantly affected the accomplishment of life habits of the participants compared to their pre-injury level. The assessment of social participation at various times provides a report on the client’s progress and allows clinicians to update his or her intervention plan, to plan follow-ups or to end the intervention. This knowledge must be considered by anyone involved in helping these children to achieve their greatest social participation.
Synthesis and Evaluation of ATP-Binding Site Directed Potential Inhibitors of Nucleoside Triphosphatases/ Helicases and Polymerases of Hepatitis C and other Selected Flaviviridae Viruses

5′-O-(4-fluorosulphonylbenzoyl)-esters of ribavirin (FSBR), adenosine (FSBA), guanosine (FSBG) and inosine (FSBI) were obtained by acylation of the 5′-OH of adenosine, guanosine, inosine, and ribavirin with 4-fluorosulphonylbenzoyl chloride (FSBCl) in HMPA. The above derivatives were tested as inhibitors of nucleoside triphosphatase (NTPase)/helicase activities of Flaviviridae: hepatitis C virus (HCV), West Nile virus (WNV), Japanese encephalitis virus (JEV) and dengue virus (DENV) and polymerase activity of HCV and WNV. When the unwinding activity of viral NTPase/helicases was tested under standard conditions, only weak inhibition was obtained with FSBI (IC50≥120 μM) and in the case of FSBG even an activation was seen. The preincubation of the NTPase/helicases with the 5′-O-FSB derivatives increased the inhibitory effect. Screening of the 5′-O-FSB derivatives on inhibition of the WNV and HCV RNA polymerases employing GTP or UTP substrates revealed rather modest inhibitory effect. FSBI exhibited the highest inhibitory activity against WNV (IC50=70 μM with UTP substrate) and HCV polymerase (IC50=80 μM with GTP substrate). Other 5′-O-FSB derivatives were very weak inhibitors or completely failed to show any activity against HCV and WNV enzymes. In contrast to the NTPase/helicases the preincubation of the polymerases did not influence the inhibition.
Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians.

We sequenced all nine exons and exon-intron junctions of the CYP2A6 gene from 33 Japanese and 28 Caucasians. We found twenty one single nucleotide polymorphisms (SNPs) including four SNPs causing amino acid substitutions, one silent SNP in exon 5, one SNP in a 5'-flanking region, four SNPs in a 3'-untranslated region, and eleven SNPs in introns. The four mutations (13G>A and 86G>A in exon 1, and 2134A>G and 2161C>T in exon 4) causing amino acid substitutions (Gly(5)Arg, Ser(29)Asn, Lys(194)Glu, and Arg(203)Ser), respectively, were as follows: SNP, 020719Kiyotani004; GENE NAME, CYP2A6; ACCESSION NUMBER, NG_000008. 4; LENGTH, 25 base; 5'-ATGCTGGCCTCAG/AGGATGCTTCTGG-3'. SNP, 020719Kiyotani005; GENE NAME, CYP2A6; ACCESSION NUMBER, NG_000008. 4; LENGTH, 25 base; 5'-AGCAGAGGAAGAG/ACAAGGGGAAGCT-3'. SNP, 020719Kiyotani011; GENE NAME, CYP2A6; ACCESSION NUMBER, NG_000008. 4; LENGTH, 25 base; 5'-CGCTTTGACTATA/GAGGACAAAGAGT-3'. SNP, 020719Kiyotani012; GENE NAME, CYP2A6; ACCESSION NUMBER, NG_000008. 4; LENGTH, 25 base; 5'-CTGTCACTGTTGC/TGCATGATGCTAG-3'. New alleles having these SNPs were designated as CYP2A6( *)13-CYP2A6( *)16.
Alignment time-scale of the microquasar GRO J1655−40

The microquasar GRO J1655−40 has a black hole with spin angular momentum apparently misaligned to the orbital plane of its companion star. We analytically model the system with a steady-state disc warped by Lense‐Thirring precession and find the time-scale for the alignment of the black hole with the binary orbit. We make detailed stellar evolution models so as to estimate the accretion rate and the lifetime of the system in this state. The secondary can be evolving at the end of the main sequence or across the Hertzsprung gap. The mass-transfer rate is typically 50 times higher in the latter case but we find that, in both the cases, the lifetime of the mass-transfer state is at most a few times the alignment time-scale. The fact that the black hole has not yet aligned with the orbital plane is therefore consistent with either model. We conclude that the system may or may not have been counter aligned after its supernova kick but that it is most likely to be close to alignment rather than counter alignment now.
Enhanced Nuclei Segmentation and Classification via Category Descriptors in the SAM Model

Segmenting and classifying nuclei in H&E histopathology images is often limited by the long-tailed distribution of nuclei types. However, the strong generalization ability of image segmentation foundation models like the Segment Anything Model (SAM) can help improve the detection quality of rare types of nuclei. In this work, we introduce category descriptors to perform nuclei segmentation and classification by prompting the SAM model. We close the domain gap between histopathology and natural scene images by aligning features in low-level space while preserving the high-level representations of SAM. We performed extensive experiments on the Lizard dataset, validating the ability of our model to perform automatic nuclei segmentation and classification, especially for rare nuclei types, where achieved a significant detection improvement in the F1 score of up to 12%. Our model also maintains compatibility with manual point prompts for interactive refinement during inference without requiring any additional training.
The difference between the upper limbs and the lower limbs in individuals on force output characteristics during stretch-shortening cycle movement

A study was conducted to investigate the difference b tween force output characteristics of the upper and lower limbs in individuals focusing on limb stifthess using a mass-spring model during exercise. Fourteen trained males perfbrmed purely concentric (PC) exercise and two kinds ofstretchshortening cycle (SSC) exercises (counter movement, rebound movement) for both the upper limbs (push-up) and lower limbs ljump). Upper and lower limb forces were assessed using the mean fbrce generated during the concentric phase ofeach exercise. Pre-stretch augmentation (augmentation) was defined as the ratio of the mean force of SSC exercise to the mean force of PC exercise, Upper and lower limb stiffhesses were calculated as the mean force divided by the vertical displacement during the eccentric phase of SSC exercise. The results were as fo11ows: 1) Mean force of SSC exercises were significantly higher than that of PC exercise in both upper and lower limbs. However, augmentation was much higher in the lower limbs than in t-he upper limbs. 2) There were significant negative correlations between stiffhess and mean force (r=-O.661, p<O.05), and stiffhess and augmentation (r=-O.743, p<O.Ol) during rebound push-up. In cgntrast, there were significant positive correlations between stiffhess and mean force (r=O.680, p<O.05), and stifihess and augrnentation (r=O,782, p<O.Ol) during rebound jump. 3) There was a significant correlation between upper mean force and lower mean force during PC exercise (r=O.607, p<O.05), However, there were no significant correlations in counter movement (r=-O.092, ns) and rebound exercise (r=-O.278, ns), These results indicate that ability to utilize the benefit ofSSC movements and optimum limb stiffhess for fbrce 1) MintJk \Jk\eeesfipt#MXil T305-8574 ecblMD<etTIiRIts1.1. 1 2) NVXn{-7pt\k>Sfl15-O056 MMas#tatuh{fi3-151 3) MiE k \esFpt#k f3058574 ecblvaO<C:ntXIthltltl mecaft mpoee= 1. Doctorat Program in Heatth and Sport Sciences, Univexsity of Tlsuicuba i-i-l Tennoctai, 71sukuba, Ibarakt 305-8574 2, Jkxpan hzstitute ofSports Sctences 3-15-1 Nbshigaoiceq Mta-ku, 71)kyo l15-O056 3, litstitute ofHeatth and Sport Sciences, University of 71sukuba 1-1-1 Te7znoctaa 7lsukuba, lbarahi 305-8574 Corresponding author icenji@fatness.taiiku. tsukuba. ec-J'p Japanese Society of Physical Education NII-Electronic Library Service apanese ooiety f hysioal duoation
Everolimus Inhibits Monocyte/Macrophage Migration in Vitro and Their Accumulation in Carotid Lesions of Cholesterol-Fed Rabbits

Monocytes/macrophages recruited into the arterial wall during atherogenesis are crucial in the initiation and progression of atherosclerosis and play a fundamental role in the destabilization process that is the main causal event of acute coronary syndromes. In the present study, we investigated the effect of the mammalian target of rapamycin inhibitor everolimus on macrophage accumulation within carotid lesions elicited by perivascular collar placement in cholesterol-fed rabbits. Everolimus (1.5 mg/kg given 1 day before collaring followed by 1 mg/kg/day for 14 days, administered by oral gavage) markedly decreased lesion macrophage content as compared with vehicle control (-65%; p < 0.01). This effect was associated with a reduction in intimal thickening and occurred in the absence of changes in plasma cholesterol concentrations. To gain insights on the potential mechanism(s) underlying this effect, we investigated the influence of everolimus on chemoattractant-induced migration of human monocytes in vitro. Pretreatment with therapeutic concentrations of everolimus (10 nM) significantly lowered monocyte chemotaxis in response to various chemotactic factors (i.e., monocyte chemoattractant protein-1/CCL2, fractalkine/CX3CL1, interleukin-8/CXCL8, complement fragment 5a, or N-formyl-Met-Leu-Phe) without inducing monocyte cell death. These results suggest that everolimus may favorably influence the atherosclerotic process by affecting the recruitment of monocytes into early lesions.
A pesca artesanal no estuário do rio Curu, Ceará - Brasil: saber local e implicações para o manejo / The artisanal fishery in the Curu river estuary, Ceará Brazil: local knowledge and implications for its management

Resumo Este estudo foi desenvolvido no estuario do rio Curu, distante 96 km a noroeste da capital Fortaleza/CE. Teve como objetivo realizar um diagnostico participativo da pesca artesanal praticada naquele estuario. A pesquisa consistiu de visitas a localidade, entre agosto de 2004 e julho de 2008, bem como de reunioes e 35 entrevistas semi-estruturadas com pescadores locais, abordando seus conhecimentos empiricos sobre as caracteristicas ecologicas do ambiente de atuacao. Os pescadores entrevistados tinham em media 43 anos de idade (± 12,8) e 25 anos de experiencia em pesca no estuario do rio Curu. Cerca de 63% nao possuiam carteira de pescador profissional, nem estavam filiados a Colonia de Pescadores Z-5, do municipio de Paracuru. Os resultados registram o desenvolvimento da pesca realizada no estuario desde 1960, bem como a falta de organizacao do setor pesqueiro na regiao e a diminuicao da producao pesqueira ao longo dos ultimos anos, devido a pesca ilegal e aos impactos e transformacoes ambientais. Sobretudo, ressalta a necessidade da realizacao de atividades para resgate e manutencao do saber empirico local, com finalidade de subsidiar a elaboracao de politicas publicas voltadas a melhoria da qualidade socio-ambiental de pescadores e pescadoras estuarinos no estado do Ceara. Abstract This study was carried in the estuary of the Curu river, distant 96 km northwest of the capital Fortaleza, Ceara, State, Brazil. The main goal of this study was to diagnosis the artisanal fishery practiced in that estuary. The research consisted on local visits, between August 2004 and July 2008; communal meetings and 35 semi-structured interviews with local fishermen, addressing their empirical knowledge about the ecological characteristics of the environment. The fishermen interviewed had on average 43 years old and 25 years of experience on fishing in the Curu estuary. About 63% had no professional documentation as fisherman, neither were members of the representative institution. The results recorded the development of fisheries conducted in the estuary since 1960, the lack of organization on the fishery sector in the region and the decrease of fisheries production in recent years. Most importantly, it highlights the necessity of studies that aim to rescue and maintain the local empirical knowledge, with the purpose to support the development of public policies to improve the social-environmental quality of estuarine fishermen in Ceara State.