Miracle-dz/UniFAR-FTUs huggingface dataset:
Infant Demand and Milk Supply. Part 2: The Short-Term Control of Milk Synthesis in Lactating Women

In this second part of our two-part commentary, milk production and milk synthesis are defined and the methods that may be used in their measurement are briefly reviewed. In particular, the rationale for the development of breast volume measurement techniques is described. We review our studies which have employed breast volume measurement techniques and propose a model for the short-term control of milk synthesis in lactating women. According to this model, the breast responds to the degree to which the infant empties the breast at each breastfeed. The frequency of milk removal may not directly affect the rate of milk synthesis except as a function of the mother's ability to store milk.
A light-weight distributed scheme for detecting ip prefix hijacks in real-time

As more and more Internet IP prefix hijacking incidents are being reported, the value of hijacking detection services has become evident. Most of the current hijacking detection approaches monitor IP prefixes on the control plane and detect inconsistencies in route advertisements and route qualities. We propose a different approach that utilizes information collected mostly from the data plane. Our method is motivated by two key observations: when a prefix is not hijacked, 1) the hop count of the path from a source to this prefix is generally stable; and 2) the path from a source to this prefix is almost always a super-path of the path from the same source to a reference point along the previous path, as long as the reference point is topologically close to the prefix. By carefully selecting multiple vantage points and monitoring from these vantage points for any departure from these two observations, our method is able to detect prefix hijacking with high accuracy in a light-weight, distributed, and real-time fashion. Through simulations constructed based on real Internet measurement traces, we demonstrate that our scheme is accurate with both false positive and false negative ratios below 0.5%.
Progressive supranuclear palsy presenting with dynamic aphasia.

BACKGROUND: Progressive supranuclear palsy (PSP) is an akinetic-rigid syndrome of unknown aetiology which usually presents with a combination of unsteadiness, bradykinesia, and disordered eye movement. Speech often becomes dysarthric but language disorders are not well recognised. METHODS: Three patients with PSP (pathologically confirmed in two) are reported in which the presenting symptoms were those of difficulty with language output. RESULTS: Neuropsychological testing showed considerable impairment on a range of single word tasks which require active initiation and search strategies (letter and category fluency, sentence completion), and on tests of narrative language production. By contrast, naming from pictures and from verbal descriptions, and word and sentence comprehension were largely intact. The degree of semantic memory impairment was also slight. CONCLUSIONS: Relatively selective involvement of cognitive processes critical for planning and initiating language output may occur in some patients with PSP. This presentation resembles the phenomenon of "verbal adynamia" or "dynamic aphasia" seen in patients with frontal lobe damage. Although definite cortical changes were present at postmortem examination, it is likely that the neuropsychological deficits reflect functional frontal deafferentation secondary to interruption of frontostriatal feedback loops.
Behavioral Intervention and Non-Uniform Bootstrap Percolation

Bootstrap percolation is an often used model to study the spread of diseases, rumors, and information on sparse random graphs. The percolation process demonstrates a critical value such that the graph is either almost completely affected or almost completely unaffected based on the initial seed being larger or smaller than the critical value. To analyze intervention strategies we provide the first analytic determination of the critical value for basic bootstrap percolation in random graphs when the vertex thresholds are nonuniform and provide an efficient algorithm. This result also helps solve the problem of "Percolation with Coinflips" when the infection process is not deterministic, which has been a criticism about the model. We also extend the results to clustered random graphs thereby extending the classes of graphs considered. In these graphs the vertices are grouped in a small number of clusters, the clusters model a fixed communication network and the edge probability is dependent if the vertices are in close or far clusters. We present simulations for both basic percolation and interventions that support our theoretical results.
Conciliatory gestures promote forgiveness and reduce anger in humans

Significance Conflict is a common feature of social life among group-living animals, but many social relationships often retain value even after conflicts have occurred. Consequently, natural selection has likely endowed humans and other animal species with cognitive systems that motivate reconciliation with interaction partners that they perceive as valuable and nonthreatening, notwithstanding prior conflict. In a large sample of people who had recently been harmed by an interaction partner, we found that conciliatory gestures, such as apologies and offers of compensation, accelerated forgiveness and reduced anger toward transgressors, largely by altering victims’ perceptions of their transgressors’ relationship value and exploitation risk. These results give insight into the design logic behind the cognitive systems that motivate human postconflict reconciliation. Conflict is an inevitable component of social life, and natural selection has exerted strong effects on many organisms to facilitate victory in conflict and to deter conspecifics from imposing harms upon them. Like many species, humans likely possess cognitive systems whose function is to motivate revenge as a means of deterring individuals who have harmed them from harming them again in the future. However, many social relationships often retain value even after conflicts have occurred between interactants, so natural selection has very likely also endowed humans with cognitive systems whose function is to motivate reconciliation with transgressors whom they perceive as valuable and nonthreatening, notwithstanding their harmful prior actions. In a longitudinal study with 337 participants who had recently been harmed by a relationship partner, we found that conciliatory gestures (e.g., apologies, offers of compensation) were associated with increases in victims’ perceptions of their transgressors’ relationship value and reductions in perceptions of their transgressors’ exploitation risk. In addition, conciliatory gestures appeared to accelerate forgiveness and reduce reactive anger via their intermediate effects on relationship value and exploitation risk. These results strongly suggest that conciliatory gestures facilitate forgiveness and reduce anger by modifying victims’ perceptions of their transgressors’ value as relationship partners and likelihood of recidivism.
Linopirdine Modulates Calcium Signaling and Stimulus-Secretion Coupling in Adrenal Chromaffin Cells by Targeting M-Type K+ Channels and Nicotinic Acetylcholine Receptors

Adrenal chromaffin cells synthesize and release catecholamines and several other transmitters that play important physiological roles in the coordinated response to stress or danger. The main trigger for secretion is acetylcholine (ACh) released from splanchnic nerve terminals that activates nicotinic ACh receptors (nAChRs) on the chromaffin cells, causing membrane depolarization and Ca2+ entry primarily through voltage-gated Ca2+ channels (Ca-channels). G protein-coupled receptors (GPCRs) can also trigger secretion, and it has been suggested that closure of M-type K+ channels might contribute to this process. However, GPCRs have multiple effects on calcium signaling and secretion, including release of intracellular Ca2+ stores, activation of second messenger pathways and kinases, and Ca2+ entry through store/receptor-operated channels. Hence, the effects of M-channel closure on [Ca2+]i signaling and transmitter release remain unclear. We have investigated the effects of linopirdine, a relatively selective blocker of M-channels, on stimulus-secretion coupling in chromaffin cells. Linopirdine produced a small increase in [Ca2+]i in ∼63% of cells because of influx through Ca-channels. However, this was not sufficient to promote catecholamine release. We also show that linopirdine reduced cholinergic-stimulated increases in [Ca2+]i and secretion, primarily through potent block of nAChRs and a subtle effect on Ca2+ entry via Ca-channels. Hence, our data support the hypothesis that M-channels help control the excitability of chromaffin cells, but additional pathways need to be recruited by GPCRs to trigger catecholamine release. Furthermore, linopirdine potently targets nAChRs to modulate stimulus-secretion coupling in adrenal chromaffin cells.
Hormonal Regulation of CD4+ T-Cell Responses in Coxsackievirus B3-Induced Myocarditis in Mice

ABSTRACT Coxsackievirus B3 infection causes significant cardiac inflammation in male, but not female, B1.Tg. Eα mice. This gender difference in disease susceptibility correlates with selective induction of CD4+ Th1 (gamma interferon-positive) cell responses in animals with testosterone, whereas estradiol promotes preferential CD4+ Th2 (interleukin-4 positive [IL-4+]) cell responses. Differences in immune deviation of CD4+ T cells cannot be explained by variation in B7-1 or B7-2 expression. Infection significantly upregulated both molecules, but no differences were detected between estradiol- and testosterone-treated groups. Significantly increased numbers of activated (CD69+) T cells expressing the γδ T-cell receptor were found in male and testosterone-treated male and female mice. In vivo depletion of γδ+ cells by using monoclonal antibodies inhibited myocarditis and resulted in a shift from a Th1 to Th2 response phenotype. Taken together, our results indicate that testosterone promotes a CD4+ Th1 cell response and myocarditis by promoting increased γδ+ cell activation.
Oxidative stress and thromboxane-dependent platelet activation in inflammatory bowel disease: effects of anti-TNF-α treatment

Summary Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here measured the urinary F2-isoprostane 8-iso-prostaglandin (PG)2α (8-iso-PGF2α), urinary 11–dehydro–thromboxane (TX) B2 (11-dehydro–TXB2) and plasma CD40L in IBD patients, and explored the in vitro action of anti-tumour necrosis factor (TNF)–α antibody infliximab on IBD differentiating megakaryocytes. Urinary and blood samples were collected from 124 IBD patients and 37 healthy subjects. Thirteen IBD patients were also evaluated before and after 6–week infliximab treatment. The in vitro effect of infliximab on patient-derived megakaryocytes was evaluated by immunoflorescence microscopy and by flow cytometry. IBD patients had significantly (p<0.0001) higher urinary 8–iso–PGF2α and 11–dehydro–TXB2 as well as plasma CD40L levels than controls, with active IBD patients displaying higher urinary and plasma values when compared to inactive patients in remission. A 6-week treatment with infliximab was associated with a significant reduction of the urinary excretion of 8–iso–PGF2α and 11–dehydro–TXB2 (p=0.008) and plasma CD40L (p=0.001). Infliximab induced significantly rescued pro-platelet formation by megakaryocytes derived from IBD patients but not from healthy controls. Our findings provide evidence for enhanced in vivo TX–dependent platelet activation and lipid peroxidation in IBD patients. Anti-TNF–α therapy with infliximab down-regulates in vivo isoprostane generation and TX biosynthesis in responder IBD patients. Further studies are needed to clarify the implication of infliximab induced-proplatelet formation from IBD megakaryocytes. Supplementary Material to this article is available online at www.thrombosis-online.com.
Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population

Human leukocyte antigen genotyping of 272 Malawian HIV patients receiving nevirapine-containing regimens (of whom 117 had nevirapine hypersensitivity) has shown that HLA-C*04:01 increases the risk of Stevens-Johnson syndrome/toxic epidermal necrolysis, with an odds ratio of 5.17 (95% confidence interval, 2.39–11.18).
YARN HAIRINESS: THE INFLUENCE OF TWIST

In this paper the various causes which determine yarn hairiness are studied with particular reference to the influence of twist. A theory of the causes of hairiness in cotton, worsted and spun rayon yarns, which is based on the work of Morton and Yen concerning the migration of fibres in yarns, is outlined. The hairiness of two-fold and woollen yarns is also studied.
Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock–induced oxidation

Testes of most male mammals present the particularity of being externalized from the body and are consequently slightly cooler than core body temperature (4–8°C below). Although, hypothermia of the testis is known to increase germ cells apoptosis, little is known about the underlying molecular mechanisms, including cold sensors, transduction pathways, and apoptosis triggers. In this study, using a functional knockout mouse model of the cold and menthol receptors, dubbed transient receptor potential melastatine 8 (TRPM8) channels, we found that TRPM8 initiated the cold‐shock response by differentially modulating cold‐and heat‐shock proteins. Besides, apoptosis of germ cells increased in proportion to the cooling level in control mice but was independent of temperature in knockout mice. We also observed that the rate of germ cell death correlated positively with the reactive oxygen species level and negatively with the expression of the detoxifying enzymes. This result suggests that the TRPM8 sensor is a key determinant of germ cell fate under hypothermic stimulation. —Borowiec, A. ‐S. , Sion, B. , Chalmel, F. , Rolland, A.D., Lemonnier, L. , De Clerck, T. , Bokhobza, A. , Derouiche, S. , Dewailly, E. , Slomianny, C. , Mauduit, C. , Benahmed, M. , Roudbaraki, M. , Jégou, B. , Prevarskaya, N. , Bidaux, G. Cold/menthol TRPM8 receptors initiate the cold‐shock response and protect germ cells from cold‐shock–induced oxidation. FASEBJ. 30, 3155–3170 (2016). www.fasebj. org
BINARIES IN GLOBULAR CLUSTERS

Recent observations have shown that globular clusters contain a significant binary population. This is a dramatic change from the conventional view of even a decade ago, which held that globular clusters formed without any binaries at all, since the observed X-ray binaries were understood to be formed through dynamical capture. Over the last few years, a number of different observational techniques have resulted in the detection of a substantial number of binaries most of which are believed to be primordial. When the many selection effects are taken into account, these detections translate into a binary abundance in globular clusters that may be somewhat smaller than those in the Galactic disk and halo, but not by a large factor. Within the current uncertainties, it is even possible that the primoridal binary abundance in globular clusters is comparable to the Galactic disk. We discuss different successful optical search techniques, based on radial-velocity variables, photometric variables, and the positions of stars in the color-magnitude diagram. In addition, we review searches in other wavelengths, which have turned up low-mass X-ray binaries and more recently a variety of radio pulsars. On the theoretical side, we give an overview of the different physical mechanisms through which individual binaries evolve. We discuss the various simulation techniques which recently have been employed to study the effects of a primordial binary population, and the fascinating interplay between stellar evolution and stellar dynamics which derive globular cluster evolution.
Recursive Trust-Region Methods for Multiscale Nonlinear Optimization

A class of trust-region methods is presented for solving unconstrained nonlinear and possibly nonconvex discretized optimization problems, like those arising in systems governed by partial differential equations. The algorithms in this class make use of the discretization level as a means of speeding up the computation of the step. This use is recursive, leading to true multilevel/multiscale optimization methods reminiscent of multigrid methods in linear algebra and the solution of partial differential equations. A simple algorithm of the class is then described and its numerical performance is shown to be numerically promising. This observation then motivates a proof of global convergence to first-order stationary points on the fine grid that is valid for all algorithms in the class.
Knowledge , Attitudes and Practices of HIV-Infected Women on Cervical Cancer Screening at a Church-affiliated Hospital

Cervical cancer is the second leading cause of female cancer-related morbidity and mortality globally representing 13% of female cancers and accounting for 11% of the total cancer deaths. Several studies have reported an association between HIV (Human Immunodeficiency Virus Infection) and cervical cancer. About 70% of people living with HIV are in Sub Saharan Africa and Zimbabwe is the fifth worst affected nation. Ironically, since there is no active screening of cervical cancer in HIV-infected people, they have to voluntarily seek cervical cancer screening. Very few women ever get the cervical cancer screening. The aim of the study was to determine the knowledge, attitude and practices of HIV infected women on cervical cancer and cervical cancer screening at Musiso Hospital, Masvingo Province, Zimbabwe. The study was done through a crosssectional survey with a sample of 208randomly selected women at Musiso OI (Opportunistic Infections) Clinic. Data was obtained through a questionnaire. Multiple variable logistic regressions models were also used to assess association between outcomes of interest and socio-demographic characteristics. All open ended questions were analysed using qualitative methods. Forty-five (21.6%) respondents claimed to know what cervical cancer is and 115(55.3%) said cervical cancer is preventable. However, 193 (92.8%) did not know any screening tests. Among the respondents 161 (77.4%) felt at risk of cervical cancer. Eighteen (9.0%) of all participants had screened for cervical cancer before and 200 (96.2%) respondents reported would like to screen for cervical cancer in the future. HIV-infected women have inadequate knowledge and a positive attitude towards cervical cancer screening. Although they are at an increased risk of cervical cancer, very few are ever screened for the cancer. There is need to incorporate cervical cancer screening in routine HIV care. Moreover, HIV positive women should be encouraged to initiate cervical cancer screening.
Pan1 regulates transitions between stages of clathrin-mediated endocytosis

The Saccharomyces cerevisiae endocytic protein Pan1 is critical for coat interactions during three transitions of the endocytic pathway. Pan1 depletion arrests endocytosis and causes actin misregulation, leading to actin flares that are connected to the coat but not the membrane. The Pan1 central region is critical for endocytic and essential functions.
Effect of Acid-Modified Clay on the Microstructure and Performance of Starch Films

In this work, thermoplastic starch-clay composite films were prepared via solution casting method. The use of acid-modified clay including kaolinite (HKAO) and vermiculite (HVER) improved the thermal properties of starch matrix. The structure of films was investigated and characterized by XRD and SEM techniques. The results showed that the well-dispersed clay particles were distributed in the starch matrix. According to TGA, DSC study and water absorption testing, the films with acid-modified clay exhibited higher water resistance and thermal properties compared to those of films containing pristine clay. These results provide the important information with using acid as the clay modifier to obtain starch-based materials with higher performance.
Argo data assimilation into HYCOM with an EnOI method in the Atlantic Ocean

Abstract. An ocean data assimilation system to assimilate Argo temperature (T) and salinity (S) profiles into the HYbrid Coordinate Ocean Model (HYCOM) was constructed, implemented and evaluated for the first time in the Atlantic Ocean (78° S to 50° N and 98° W to 20° E). The system is based on the ensemble optimal interpolation (EnOI) algorithm proposed by Xie and Zhu (2010), especially made to deal with the hybrid nature of the HYCOM vertical coordinate system with multiple steps. The Argo T–S profiles were projected to the model vertical space to create pseudo-observed layer thicknesses (Δ pobs), which correspond to the model target densities. The first step was to assimilate Δ pobs considering the sub-state vector composed by the model layer thickness (Δ p) and the baroclinic velocity components. After that, T and S were assimilated separately. Finally, T was diagnosed below the mixed layer to preserve the density of the model isopycnal layers. Five experiments were performed from 1 January 2010 to 31 December 2012: a control run without assimilation, and four assimilation runs considering the different vertical localizations of T, S and Δ p. The assimilation experiments were able to significantly improve the thermohaline structure produced by the control run. They reduced the root mean square deviation (RMSD) of T and S calculated with respect to Argo independent data in 34 and 44%, respectively, in comparison to the control run. In some regions, such as the western North Atlantic, substantial corrections in the 20 °C isotherm depth and the upper ocean heat content towards climatological states were achieved. The runs with a vertical localization of Δ p showed positive impacts in the correction of the thermohaline structure and reduced the RMSD of T (S) from 0.993 °C (0.149 psu) to 0.905 °C (0.138 psu) for the whole domain with respect to the other assimilation runs.