Miracle-dz/UniFAR-FTUs huggingface dataset:
The NGAL Test for early diagnosis of acute kidney injury

s reviewed: 62 Exclusion criteria: case studies, editorials, letters, reviews, conference proceedings/abstracts, animal studies, and non-English language studies Studies for review: 1 About this briefing Medtech innovation briefings summarise the published evidence and information available for individual medical technologies. The briefings provide information to aid local decision-making by clinicians, managers, and procurement professionals. Medtech innovation briefings aim to present information and critically review the strengths and weaknesses of the relevant evidence, but contain no recommendations and are not formal NICE guidance. Changes after publication February 2014: Minor maintenance Development of this briefing This briefing was developed for NICE by the KITEC KHP External Assessment Centre (EAC). The Interim process and methods statement sets out the process NICE uses to select topics, and how the briefings are developed, quality assured and approved for publication. Project team KITEC KHP EAC Medical Technologies Evaluation Programme, NICE Peer reviewers and contributors • James Clinch, Technical Adviser, KITEC KHP. • Elizabeth Morris, Technical Adviser, KITEC KHP. The NGAL Test for early diagnosis of acute kidney injury (MIB3) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-andconditions#notice-of-rights). Page 31 of 32 • Muralikrishnan Radhakrishnan Kartha, Health Economist, KITEC KHP. • Stephen Keevil, Centre Director, KITEC KHP. • Cornelius Lewis, Centre Director, KITEC KHP. Specialist commentators The following specialist commentators provided comments on a draft of this briefing: • Dr Ashley Garner, Principal Clinical Biochemist, Leeds Teaching Hospitals NHS Trust • Dr Edmund Lamb, Consultant Clinical Scientist, East Kent Hospitals University NHS Foundation Trust • Dr David Milford, Consultant Nephrologist, Birmingham Children's Hospital NHS Foundation Trust • Dr Sheetal Bhojani, Paediatric Nephrology Trainee, NHS Greater Glasgow &Clyde Copyright © National Institute for Health and Care Excellence, 2014. All rights reserved. NICE copyright material can be downloaded for private research and study, and may be reproduced for educational and not-for-profit purposes. No reproduction by or for commercial organisations, or for commercial purposes, is allowed without the written permission of NICE. ISBN: 978-1-4731-0460-0 The NGAL Test for early diagnosis of acute kidney injury (MIB3) © NICE 2020. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-andconditions#notice-of-rights). Page 32 of 32
Reducing overweight and obesity: closing the gap between primary care and public health.

BACKGROUND Although overweight and obesity are major risk factors for ill health and premature death, leading to significant increases in workload and prescribing costs, primary health care providers continue to find managing overweight and obesity a difficult business. OBJECTIVES Six questions are addressed in an attempt to close the gap between primary care activities and public health goals to reduce overweight and obesity: what is overweight and obesity; what is the health impact of overweight and obesity; is individually directed advice effective in reducing overweight and obesity; can we increase the involvement of primary care in reducing overweight and obesity; how can public health actions complement the role of primary care; and how do we chose cost-effective interventions? METHOD Systematic reviews and key texts were identified from literature searches to provide a narrative summary to answer the six questions. RESULTS Overweight is defined as a body mass index (BMI) of > or = 25 and obesity as a BMI of > or = 30 where BMI = weight (kg)/height (m(2)). There is a positive relationship between the level of BMI and a wide range of conditions, including cancers and cardiovascular diseases. There is evidence that individually directed advice can reduce overweight and obesity or its risk. There is mixed evidence for the effectiveness of strategies in increasing the involvement of primary care in reducing overweight and obesity. There are many examples of public health actions that complement the role of primary care in reducing overweight and obesity. Overall cost-effective policy analyses have not been done per se for overweight and obesity but have shown that a combination of personal and non-personal interventions can be effective and cost-effective in reducing cardiovascular events. CONCLUSION The gap between primary care and public health in reducing overweight and obesity can be closed, but it requires sustained political support and investment.
Adult lung stem cells and their contribution to lung tumourigenesis

The isolation and characterization of lung stem and progenitor cells represent an important step towards the understanding of lung repair after injury, lung disease pathogenesis and the identification of the target cells of transformation in lung carcinogenesis. Different approaches using prospective isolation of progenitor cells by flow cytometry or lineage-tracing experiments in mouse models of lung injury have led to the identification of distinct progenitor subpopulations in different morphological regions of the adult lung. Genetically defined mouse models of lung cancer are offering new perspectives on the cells of origin of different subtypes of lung cancer. These mouse models pave the way to further investigate human lung progenitor cells at the origin of lung cancers, as well as to define the nature of the lung cancer stem cells. It will be critical to establish the link between oncogenic driver mutations recently discovered in lung cancers, target cells of transformation and subtypes of lung cancers to enable better stratification of patients for improved therapeutic strategies.
Mucinous Cystadenoma: A Rare Abdominal Mass in Childhood

Ovarian masses are uncommon in children. Only 10 - 17 % of them are epithelial tumours. Mucinous cystadenoma in children is a benign cystic ovarian neoplasm, and it is met very rarely in the medical literature. We present a 13-year-old girl with a giant ovarian mucinous cystadenoma.
Developmental foundations of externalizing problems in young children: The role of effortful control

Examined associations between effortful control temperament and externalizing problems in 220 3-year-old boys and girls, controlling for co-occurring cognitive and social risk factors. We also considered possible additive and/or interactive contributions of child dispositional anger and psychosocial adversity, and whether relations between effortful control and early externalizing problems were moderated by child gender. Individual differences in children's effortful control abilities, assessed using behavioral and parent rating measures, were negatively associated with child externalizing problems reported by mothers, fathers, and preschool teachers. These associations were not overshadowed by other cognitive or social risk factors, or by other relevant child temperament traits such as proneness to irritability. Further analyses revealed that associations between externalizing problem behavior and effortful control were specific to components of child problem behavior indexing impulsive-inattentive symptoms. Thus, children's effortful control skills were important correlates of children's early disruptive behavior, a finding that may provide insight into the developmental origins of chronic behavioral maladjustment.This research was supported by a grant from the National Institute of Mental Health (RO1MH57489) to Sheryl Olson and Arnold Sameroff. We are very grateful to the children, parents, teachers, and preschool administrators who participated, and to the many individuals who gave us invaluable help with data collection and coding, especially Gail Benninghoff, Meribeth Gandy Pezda, Lisa Alvarez, Sara Miceli, and Felicia Kleinberg. We also thank the administrators of the University of Michigan Children's Center for their generous assistance, Grazyna Kochanska for allowing us to use her behavioral battery of effortful control tasks, Kathy Murray for helping us with numerous details concerning the behavioral battery, and Mary Rothbart, Jack Bates, Patricia Kerig, and Thomas Power for allowing us to use their parent self-report measures.
Impacts to Productivity in the Painting Trades

The "Painting Trades" include commercial and industrial painters and drywall finishers, which are normally represented by the same labor union for collective bargaining purposes. They are also members of the same construction trade organization, the Finishing Contractors Association (FCA). Labor is the greatest variable cost of performance for these trades and so, labor productivity is a critical concern of these trade contractors. New and evolving technologies for the collecting of labor productivity data have emerged in recent years, however this data cannot be used in absence of some evidence exogenous environmental influences actually impact the trade contractors' productivity. The FCA funded this research to better understand the factors which impact labor productivity and to what degree. The FCA collected data on 140 commercial painting projects, 56 industrial painting projects, and 147 drywall finishing projects. Fifteen productivity variables were derived from a review of the literature and in discussions with an expert panel of industry executives, selected by the FCA Executive Director1. The data was collected by the FCA using an online survey sent to FCA member contractors. Correlation matrices and single linear regression analyses were performed on the data which revealed the majority of the variables were negatively correlated with labor productivity and were statistically significant at very high levels. This is really project and construction management research, however even though the technology now exists to collect production data in the field, without underlying studies, like this one, linking changes in productivity to exogenous impacts, merely collecting data will be unhelpful.
The impact of dieting status and restraint on post-exercise energy intake in overweight females

OF THE THESIS THE IMPACT OF DIETING STATUS AND RESTRAINT ON POST-EXERCISE ENERGY INTAKE IN OVERWEIGHT FEMALES by Cristina Visona Andersen Florida International University, 2002 Miami, Florida Professor Valerie George, Major Professor This study investigated the impact of an acute bout of physical activity on postexercise energy intake (PE-EI) in overweight females who were dieting with high restraint (D-HR) and non-dieting with either high restraint (ND-HR) or low restraint (ND-LR). PE-EI at lunch and 12-hours after was compared on the exercise (E) and a nonexercise (NE) day. There was a significant interaction (F (2,33)= 4.12, p = 0.025) of dieting/restraint status and condition (E vs. NE day) on the 12-hour El. The D-HR ate 519 ± 596 kcal more on the E than on the NE day; while the ND-HR ate 177 ± 392 kcal less on the E than on the NE day. The results of this study demonstrate that the impact of exercise on PE-EI is determined by both a physiological and psychological response. Dieting status, dietary restraint, level of disinhibition and cognitive factors may influence PE-EI and weight.
The Impact of the London Olympics Announcement on Property Prices

This study estimates the impact of the London 2012 Olympics announcement on property prices. Using a self-constructed dataset of a sample of property transactions, it is estimated that properties in host boroughs are sold between 2.1 and 3.3 per cent higher, depending on the definition of the impact area. A similar investigation based on radius rings suggests that properties up to three miles away from the main Olympic stadium sell for 5 per cent higher. It is estimated that the overall impact on the price of properties in host boroughs amounts to £1.4 billion, having substantial social and financial implications for existing residents.
EPISODIC DEPOSITION OF Mn MINERALS IN COCKADE BRECCIA STRUCTURES IN THREE LOW-SULFIDATION EPITHERMAL DEPOSITS: A MINERAL STRATIGRAPHY AND FLUID-INCLUSION APPROACH

Mineralogical and fluid-inclusion studies have been conducted on Mn-rich breccias from three low-sulfidation epithermal gold deposits, Cirotan (Indonesia), Orcopampa (Peru) and Cavnic (Romania). In these deposits, the manganiferous minerals occur within cockade breccias that precede most of the deposition of sulfide. Cockade breccias consist of a lithic or sulfide nucleus, a few centimeters across, encrusted by several concentric envelopes that can be subdivided into three successive zones. Each zone may be composed of several stacked sequences of deposition. The Mn minerals are mainly clustered within the internal pinkish zone close to the nucleus, that also comprises quartz, “adularia” and sparse sulfides. Within this Mn mineral zone, each sequence begins with the deposition of Mn silicate, close to the rhodonite end-member (MnSiO 3 ), that fully or partially grades into Mn carbonate, close to the rhodochrosite (MnCO 3 ) end-member, before the deposition of the next sequence. The intermediate zone (the quartz–sulfide zone) consists of quartz–sulfide sequences, with minor Mn silicates. Each sequence begins with fine-grained quartz, indicating a high rate of nucleation, which becomes coarser grained and irregular at the end of the sequence. Chlorite and sulfides are associated with quartz at the end of this zone. The external zone of the cockades is characterized by comb quartz, associated with illite, calcite and, sparingly, manganoan dolomite. The mineralogical zonation illustrated by the cockades expresses a general evolution of the depositional process with time, with a progressive Mn-depletion and Ca-enrichment. No kutnohorite has been observed. Fluid inclusions from the three zones are all two-phase aqueous inclusions (L + V). The fluid salinities are similar in all the deposits and do not exceed 2.6 wt% NaCl eq., the final comb quartz from Orcopampa excepted. Two isenthalpic boiling events are recorded in relation with brittle deformation. The replacement of rhodonite by rhodochrosite revealed in each sequence of the Mn mineral zone could result in a temperature drop in relation to these boiling events, which release CO 2 and increase pH.
Usefulness of the Hepatitis C Virus Core Antigen Assay for Screening of a Population Undergoing Routine Medical Checkup

ABSTRACT We studied the usefulness of the recently designed Trak-C assay for the detection and quantification of the hepatitis C virus (HCV) core antigen (Ag) for the screening of HCV infection in 4,201 subjects selected from 74,150 consecutive volunteers undergoing routine medical checkups. Subjects were selected for screening because they had risk factors (group II, n = 321) and/or elevated alanine transaminase activity (group I, n = 3847). Initially, the anti-HCV antibody assay and the Trak-C assay were performed on each patient. Subsequently, the Trak-C assay was performed only when the anti-HCV enzyme immune assay (EIA) was positive. Positive samples were further evaluated for anti-HCV antibodies by a third-generation strip immunoblot assay and for HCV RNA. Four samples (1.2%) from group II and 113 (2.9%) from group I were anti-HCV EIA positive. We also tested 33 subjects who previously tested positive for anti-HCV in our medical center. Among the 150 anti-HCV EIA-positive samples, the HCV core Ag result was in accord with the HCV RNA result in 146 cases (97.3%). When the EIA result was positive, the HCV core Ag concentration and the HCV RNA load were correlated (r2 = 0.78; P < 0.001). Four samples with low viral loads were Trak-C negative but HCV RNA positive. Among the 2,395 anti-HCV EIA-negative serum samples collected during the first part of the study, 17 (0.7%) were found to contain very low levels of HCV core Ag (<8.5 pg/ml, the cutoff value being 1.5 pg/ml). All these samples were HCV RNA negative and considered to be false positives. This was confirmed by HCV core Ag neutralization analysis. The HCV core Ag assay is a useful method in the screening strategy of HCV infection and provides a reliable means of distinguishing between current and cleared HCV infections that is well correlated with HCV RNA testing.
The Interplay Of Cultural Syndromes And Personality In Predicting Life Satisfaction

This study explored how personality and cultural variables influence subjective well-being (SWB) in two different U.S. ethnic groups: Asian Americans and European Americans. Structural equation modeling analyses supported a hypothesized culture? personality model of SWB, in which the cultural syndromes of individualism and collectivism predict variations on personality dispositions (Big Five), which, in turn, influence life satisfaction through self- and relational esteem. Despite ethnic mean-level differences found for many of the variables, none of the pathways in the culture? personality model of SWB differed across our two ethnic groups. Furthermore, the culture? personality model of SWB fit the data more adequately than a competing personality? culture model of SWB, in which personality dispositions preceded cultural syndromes in predicting life satisfaction. A consistent finding was the stronger weight of self-esteem (compared with relational esteem) in predicting life satisfaction for both ethnic groups. Results are discussed in the context of acculturation theory and recent cultural psychology views.
Common Degradative Pathways of Morpholine, Thiomorpholine, and Piperidine by Mycobacterium aurum MO1: Evidence from1H-Nuclear Magnetic Resonance and Ionspray Mass Spectrometry Performed Directly on the Incubation Medium

ABSTRACT In order to see if the biodegradative pathways for morpholine and thiomorpholine during degradation by Mycobacterium aurumMO1 could be generalized to other heterocyclic compounds, the degradation of piperidine by this strain was investigated by performing1H-nuclear magnetic resonance directly with the incubation medium. Ionspray mass spectrometry, performed without purification of the samples, was also used to confirm the structure of some metabolites during morpholine and thiomorpholine degradation. The results obtained with these two techniques suggested a general pathway for degradation of nitrogen heterocyclic compounds by M. aurum MO1. The first step of the degradative pathway is cleavage of the C—N bond; this leads formation of an intermediary amino acid, which is followed by deamination and oxidation of this amino acid into a diacid. Except in the case of thiodiglycolate obtained from thiomorpholine degradation, the dicarboxylates are completely mineralized by the bacterial cells. A comparison with previously published data showed that this pathway could be a general pathway for degradation by other strains of members of the genus Mycobacterium.
Association between Atmospheric Fine Particulate Matter and Hospital Admissions for Chronic Obstructive Pulmonary Disease in Southwestern Taiwan: A Population-Based Study

Objectives: This paper reports on the findings of a population-based study to evaluate the relationship between atmospheric fine particulate matter (PM2.5) levels and hospital admissions for chronic obstructive pulmonary disease (COPD) in southwestern Taiwan over a three-year period, 2008–2010. Methods: Data on hospital admissions for COPD and PM2.5 levels were obtained from the National Health Insurance Research database (NHIRD) and the Environmental Protection Administration from 2008 to 2010, respectively. The lag structure of relative risks (RRs) of hospital admissions for COPD was estimated using a Poisson regression model. Results: During the study period, the overall average hospitalization rate of COPD and mean 24-h average level of PM2.5 was 0.18% and 39.37 μg/m3, respectively. There were seasonal variations in PM2.5 concentrations in southwestern Taiwan, with higher PM2.5 concentrations in both spring (average: 48.54 μg/m3) and winter (49.96 μg/m3) than in summer (25.89 μg/m3) and autumn (33.37 μg/m3). Increased COPD admissions were significantly associated with PM2.5 in both spring (February–April) and winter (October–January), with the relative risks (RRs) for every 10 μg/m3 increase in PM2.5 being 1.25 (95% CI = 1.22–1.27) and 1.24 (95% CI = 1.23–1.26), respectively, at a lag zero days (i.e., no lag days). Lag effects on COPD admissions were observed for PM2.5, with the elevated RRs beginning at lag zero days and larger RRs estimates tending to occur at longer lags (up to six days, i.e., lag 0–5 days). Conclusions: In general, findings reveal an association between atmospheric fine particulate matter (PM2.5) and hospital admissions for COPD in southwestern Taiwan, especially during both spring and winter seasons.
Investigation of Research towards Efficient Social Peer-to-Peer Networks

Peer-to-peer (P2P) networks attract attentions worldwide with their great success in file sharing networks (e.g. Napster, Gnutella, BitTorrent, and Kazaa). In the last decade, numerous studies have been devoted to the problem of resource discovery in P2P networks. However, efficient resource discovery remains a key challenge for large-scale P2P networks. An investigation of existing research on resource discovery towards efficient social P2P networks will be given in this paper.
Married Women in Missions: The Effects of Cross-Cultural and Self Gender-Role Expectations on Well-Being, Stress, and Self-Esteem

The present study explored the effects of self-expectations and societal expectations of the host culture on the well-being of 37 married missionary women. The results did not support a relationship between the expectations of the host culture, and well-being. Homemakers appeared to be more relaxed and to experience life as more satisfying and interesting than women involved more actively in the missions task. The congruence of roles with self-expectations, role satisfaction, and freedom in choosing a role emerged as highly related to several indices of well-being. These findings highlight the centrality of freedom in choosing a role, and suggest that important subcultural differences in self-expectations exist in the Christian subculture which should be taken into account in research on women's issues.
Nurturing parenting capability: the early years [Wider Benefits of Learning Research Report No. 30]

This report examines parenting from babyhood to early childhood. We first consider what previous studies have revealed about the nature of good parenting and the determinants of parenting in the early years. Using data from the Avon Longitudinal Study of Parents and Children we then set out to establish whether the individual characteristics of mothers and children, and factors such as mothers’ social networks and marital relations, predict certain types of parenting behaviours. We do this by examining how 1,136 mothers interacted with their child when asked to share a picture book with them. This observation exercise, which measured parental warmth and teaching behaviours, took place when the child was aged one, then again at age five. Lastly, we address the implications of our findings for policy and practice.