Miracle-dz/UniFAR-FTUs huggingface dataset:
Pure Transvaginal Appendectomy Versus Traditional Laparoscopic Appendectomy: More Procedure Time but Less Length of Hospital Stay.

Annals of Surgery Volume 262, Number 6 P1⁄4 0.38) and mean length of hospital stay (TVA: 1.1 0.1 days vs LA: 1.2 0.1 days, P1⁄4 0.53) were not statistically significant. ’’ They also commented that similar operative times could be attributed to the single incision of the TVA, previous single port experience of the surgeon, and the assistance of the gynecologists. According to my statistical analysis, there were statistically significant differences between the groups by the means of operating time and length of hospital stay. When I compared the operating time with Student t test as mentioned by the authors (TVA—n: 18, mean: 44.4 minutes, standard deviation: 4.5 minutes vs LA—n: 22, mean: 39.8 minutes, standard deviation: 2.6 minutes), the P value was less than 0.001, not 0.38 as published in the journal. Similarly, the P value of length of hospital stay was 0.0034,
Combining the Technology Acceptance Model and Uses and Gratifications Theory to examine the usage behavior of an Augmented Reality Tour-sharing Application

An intelligent tour service system including an augmented reality (AR) tour-sharing Application (APP) and a query-answering server was developed in this study to promote tourist attractions involving local Hakka culture in Thailand. Subsequently, use of this APP to navigate Hakka culture tourist attractions in Thailand was observed. The novel random neural networks (RNNs) were proposed to obtain query-answering services, and the practical experimental results showed that the accuracy of RNNs was 99.51%. This study also integrated the Technology Acceptance Model with Uses and Gratifications Theory to predict the gratification, usage intention, and user attitudes toward marketed attractions of the AR tour-sharing APP. A questionnaire survey was conducted, and 446 valid questionnaires were returned. The following results were obtained: (a) self-presentation and perceived usefulness (PU) directly influenced gratification; (b) perceived entertainment indirectly influenced gratification through perceived ease of use and PU, and information sharing indirectly influenced gratification through PU; and (c) gratification was significantly and positively related to usage intention and attitude toward attractions. Based on these results, suggestions that new technology marketing can be used to promote causes other than Hakka tourist attractions established in Thailand can be contrived. For example, the tour-sharing APP developed in this study could be applied to emphasize the characteristics of Thai Hakka culture; users’ fondness for self-presentation and information sharing can be used for word-of-mouth marketing to attract additional visitors. In addition, this research provides a reference for enterprises and marketers regarding the use of AR tour-sharing APPs to market tourist attractions, and also for future related studies.
Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region

The nucleotide sequence of human thrombospondin (TS) mRNA has been determined from human fibroblast and endothelial cDNAs. The sequence of 5802 bp begins 110 bp upstream from the initiator codon and includes the entire 3' untranslated region (UTR) of the mRNA. The coding region (3510 bp) specifies a protein of 1170 amino acids with all of the known features of the TS subunit (Frazier, W. A. 1987. J. Cell Biol. 105:625- 632). The long 3' UTR of 2166 nucleotides is extremely A/T-rich, particularly in the latter half. It contains 37 TATT or ATTT(A) sequences that have been suggested as mediators of the stability of mRNAs for cytokines, lymphokines, and oncogenes (Shaw, G., and R. Kamen. 1986. Cell. 46:659-667). Another unusual feature of the 3' UTR of TS mRNA is a stretch of 42 nucleotides of which 40 are thymidines (uridine in the mRNA) including an uninterrupted sequence of 26 thymidines. This region is flanked by two sets of direct repeats suggesting that it may be an insertion element of retrotranscriptional origin. Comparison of the 3' untranslated region of TS mRNA with the GenBank data base indicates the greatest degree of similarity with an alpha-interferon gene which contains a number of the TATT/ATTT consensus sites. The degree of similarity between the TS and interferon sequences is the same in regions of the interferon gene corresponding to its coding and noncoding regions suggesting that most of the TS 3' UTR may be derived from an interferon gene or pseudogene. The features of the TS mRNA 3' UTR provide a potential explanation for the rapid regulation of TS message observed in cultured cells in response to PDGF and suggest that TS is a member of a group of proteins which are intimately involved in the control of cell growth and differentiation.
Modelling colour constancy in fish: implications for vision and signalling in water

ABSTRACT Colour vision and colour signals are important to aquatic animals, but light scattering and absorption by water distorts spectral stimuli. To investigate the performance of colour vision in water, and to suggest how photoreceptor spectral sensitivities and body colours might evolve for visual communication, we model the effects of changes in viewing distance and depth on the appearance of fish colours for three teleosts: a barracuda, Sphyraena helleri, which is dichromatic and two damselfishes, Chromis verater and Chromis hanui, which are trichromatic. We assume that photoreceptors light-adapt to the background, thereby implementing the von Kries transformation, which can largely account for observed colour constancy in humans and other animals, including fish. This transformation does not, however, compensate for light scattering over variable viewing distances, which in less than a metre seriously impairs dichromatic colour vision, and makes judgement of colour saturation unreliable for trichromats. The von Kries transformation does substantially offset colour shifts caused by changing depth, so that from depths of 0 to 30 m modelled colour changes (i.e. failures of colour constancy) are sometimes negligible. However, the magnitudes and directions of remaining changes are complex, depending upon the specific spectral sensitivities of the receptors and the reflectance spectra. This predicts that when judgement of colour is important, the spectra of signalling colours and photoreceptor spectral sensitivities should be evolutionarily linked, with the colours dependent on photoreceptor spectral sensitivities, and vice versa. Summary: Models of light propagation in water and visual mechanisms show how changes in depth and distance alter visible spectra, and predict the consequences for fish colour vision and colour signals.
Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society, and American Urological Association: endorsed by the American Society for Radiation Oncology.

Androgen-deprivation therapy (ADT) is a widely used treatment for prostate cancer. Recently, several studies have reported an association between ADT and an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.1-5 These reports have led to increased interest and discussion regarding the metabolic effects of ADT and its possible association with increased cardiovascular risk. In addition, likely as a result of these reports, internists, endocrinologists, and cardiologists are now being consulted regarding the evaluation and management of patients in whom ADT is being initiated. Most of these physicians are not aware of the possible effects of ADT on cardiovascular risk factors or the issues regarding ADT and cardiovascular disease. Therefore, this multidisciplinary writing group has been commissioned to review and summarize the metabolic effects of ADT, to evaluate the data regarding a possible relation between ADT and cardiovascular events in patients with prostate cancer, and to generate suggestions regarding the evaluation and management of patients, both with and without known cardiac disease, in whom ADT is being initiated (Table 1). TABLE 1 Prospective Studies of the Effects of ADT on Cardiac Risk Factors ADT was first used in prostate cancer for patients with overt metastatic disease,7 and it remains the mainstay of therapy for this group. ADT combined with external-beam radiation therapy is a standard of care in the treatment of men with high-risk prostate cancer, on the basis of evidence that shows a survival benefit in multiple randomized controlled trials.8-13 However, ADT is also often used for other prostate cancer states (eg, for prostate volume reduction in men planning to undergo definitive local therapy with brachytherapy, or in the case of rising prostate-specific antigen after definitive local treatment),14,15 and in these cases, its role in prolonging survival is less certain.
Mast Cells Play No Role in the Pathogenesis of Postoperative Ileus Induced by Intestinal Manipulation

Introduction Intestinal manipulation (IM) during abdominal surgery results in intestinal inflammation leading to hypomotility or ileus. Mast cell activation is thought to play a crucial role in the pathophysiology of postoperative ileus (POI). However, this conclusion was mainly drawn using mast cell-deficient mouse models with abnormal Kit signaling. These mice also lack interstitial cells of Cajal (ICC) resulting in aberrant gastrointestinal motility even prior to surgery, compromising their use as model to study POI. To avoid these experimental weaknesses we took advantage of a newly developed knock-in mouse model, Cpa3Cre/+, devoid of mast cells but with intact Kit signaling. Design The role of mast cells in the development of POI and intestinal inflammation was evaluated assessing gastrointestinal transit and muscularis externa inflammation after IM in two strains of mice lacking mast cells, i.e. KitW-sh/W-sh and Cpa3Cre/+ mice, and by use of the mast cell stabilizer cromolyn. Results KitW-sh/W-sh mice lack ICC networks and already revealed significantly delayed gastrointestinal transit even before surgery. IM did not further delay intestinal transit, but induced infiltration of myeloperoxidase positive cells, expression of inflammatory cytokines and recruitment of monocytes and neutrophils into the muscularis externa. On the contrary, Cpa3Cre/+ mice have a normal network of ICC and normal gastrointestinal. Surprisingly, IM in Cpa3Cre/+ mice caused delay in gut motility and intestinal inflammation as in wild type littermates mice (Cpa3+/+). Furthermore, treatment with the mast cell inhibitor cromolyn resulted in an inhibition of mast cells without preventing POI. Conclusions Here, we confirm that IM induced mast cell degranulation. However, our data demonstrate that mast cells are not required for the pathogenesis of POI in mice. Although there might be species differences between mouse and human, our results argue against mast cell inhibitors as a therapeutic approach to shorten POI.
AN INTRODUCTION TO THE POST-CRITICAL BELIEF SCALE: INTERNAL STRUCTURE AND EXTERNAL RELATIONSHIPS

Recently, Fontaine, Duriez, Luyten and Hutsebaut (2003) have shown that the Post-Critical Belief Scale (PCBS; Duriez, Fontaine & Hutsebaut, 2000) captures the two orthogonal bipolar dimensions of Exclusion versus Inclusion of Transcendence and Literal versus Symbolic along which Wulff (1991, 1997) organized the various possible approaches to religion. This chapter outlines the original and valuable contribution of the PCBS to the field of the psychology of religion by showing how the PCBS sheds a new light on several hotly debated topics within he psychology of religion.
A comparison of the effects of suxamethonium and tubocurarine in patients in London and New York.

SUMMARY The effects of suxamethonium and tubocurarine were studied in London and New York patients anaesthetized with thiopentone, nitrous oxide and halothane. The action of tha muscle relaxants were assessed by measurement of the twitch respone of the adductor pollicis muscle to supramaximal stimulation of the ulnar nerve. The duration of action of suxamethonium (1 mg/kg) was less in London patients than in a comparable group of New York patients. With tubocurarine (0.1 mg/kg) the magnitude and duration of action was less in London than in New York patients. In a group of Amercian patients at a United States Air Force (USAF) hospital the magnitude and duration of action of tubocurarine (0.1 mg/kg) was similar to that seen in New York patients. It was also observed that the response to tubocurarine (0.1 mg/kg) was affected by the prior administration of suxamethonium (1 mg/kg). Both the magnitude and duartion of action of tuborcurarine were greater in patients who had previously received suxamethonium than in those who had not.
Correspondence Between Verbal Behavior About Reinforcers and Performance Under Schedules of Reinforcement.

Important advancements have been made in the identification of reinforcers over the past decade. The use of preference assessments has become a systematic way to identify preferred events that may function as reinforcers for an individual's behavior. Typically, preference assessments require participants to select stimuli through verbal surveys or engagement with stimuli as preferred or non-preferred. Not all studies go on to directly test the effects of the preferred stimuli, and even fewer studies directly test for the effects of the non- preferred stimuli. The present study systematically identified preferred and non-preferred stimuli in adult human subjects by verbal report and then proceeded to test the effects of both verbally reported preferred and non preferred events on single and concurrent schedules of reinforcement. The results are discussed in terms of contemporary concerns regarding preference and reinforcer assessments.
The role of symptom distress and goal attainment in promoting aspects of psychological recovery for consumers with enduring mental illness

Background: Conceptualizations of recovery involve more than just symptom amelioration and include the development of hope, meaning and self-identity. Goal attainment increases wellbeing within non-clinical samples and mental health consumers report its facilitative value for psychological recovery. There is a lack of empirical data regarding the impact of goal progress/attainment on mental health outcome for consumers with enduring mental illness. Aims: (i) To examine whether baseline measures of symptoms, functioning and recovery are associated with greater goal progress, and (ii) to examine the impact of goal attainment on improvements in mental health outcome. Method: Seventy-one consumers with enduring mental illness who were receiving case-management support from mental health services in eastern Australia participated in the study. Level of attainment for case-management goals was examined against mental health outcome measures for the corresponding goal-setting period. Results: Path modelling indicated that goal attainment mediated the relationship between baseline (pre-goal setting) levels of symptom distress and progress on recovery constructs; hope, self-confidence, sense of purpose and positive identity. Conclusions: When symptoms are perceived as less distressing consumers are better able to progress toward their case-management goals, which in turn promotes aspects of psychological recovery.
A comparative analysis of embryo implantation potential in patients with severe teratozoospermia undergoing in-vitro fertilization with a high insemination concentration or intracytoplasmic sperm injection.

The objective of this study was to assess fertilization, implantation and pregnancy rates in infertile patients with severe teratozoospermia [P (poor prognosis) pattern sperm morphology assessed by strict criteria] treated by in-vitro fertilization (IVF) using a high insemination concentration (HIC), or by intracytoplasmic sperm injection (ICSI). This was a retrospective cohort study performed in an academic tertiary institution. The outcome of 115 consecutive ICSI cycles was compared to that of a similar number of cycles of IVF with HIC performed during a similar time frame and matched by woman's age and basal serum (cycle day 3) follicle stimulating hormone concentrations. The inclusion criteria were sperm morphology </=4% normal forms (P pattern) and >/=1x10(6) total motile spermatozoa per ejaculate. The diploid fertilization rate in the HIC-IVF group was 86% and in the ICSI group 68% (P < 0.05). Importantly, an equal number of embryos was transferred to both groups of patients. The morphological quality of the embryos (proportion of transfers having superior morphology embryo scores) was significantly better in the ICSI group than in the patients receiving HIC-IVF. Although there was a clear trend for better implantation and pregnancy rates in the ICSI group, these differences were not statistically significant. We conclude that, although HIC-IVF resulted in a higher fertilization rate than ICSI in patients with severe teratozoospermia, ICSI produced a significantly higher proportion of morphologically superior embryos with a tendency towards a higher implantation potential. Therefore, teratozoospermic patients having adequate numbers of motile spermatozoa should be offered ICSI as an alternative to modified (HIC) IVF treatment.
PRÁCTICAS EDUCATIVAS PATERNAS Y PROBLEMAS INTERNALIZANTES Y EXTERNALIZANTES EN ADOLESCENTES ESPAÑOLES

Parenting practices and internalizing and externalizing problems in Spanish adolescents. The goal of this study was to analyze the relationship between parenting practices and internalizing and externalizing problems presented by a group of adolescents according to their gender. Four hundred and sixty-nine secondary school students (aged between 12 and 18) participated in this study. The adolescents presented differences in perception of the educational practices of both parents as a function of their gender. Negative parenting practices were positively related to adolescents' internalizing and externalizing problems, whereas positive practices were negatively related to externalizing problems. Moreover, differences between boys and girls were found in predictor variables of problems, and the predictive power of the variables was higher for externalizing problems.
Responsiveness of the activities of daily living scale of the knee outcome survey and numeric pain rating scale in patients with patellofemoral pain.

OBJECTIVE To assess internal and external responsiveness of the Activity of Daily Living Scale of the Knee Outcome Survey and Numeric Pain Rating Scale on patients with patellofemoral pain. DESIGN One group pre-post design. SUBJECTS A total of 60 individuals with patellofemoral pain (33 women; mean age 29.9 (standard deviation 9.6) years). METHODS The Activity of Daily Living Scale and the Numeric Pain Rating Scale were assessed before and after 8 weeks of physical therapy program. Patients completed a global rating of change scale at the end of therapy. The standardized effect size, Guyatt responsiveness index, and the minimum clinical important difference were calculated. RESULTS Standardized effect size of the Activity of Daily Living Scale was 0.63, Guyatt responsiveness index was 1.4, area under the curve was 0.83 (95% confidence interval: 0.72, 0.94), and the minimum clinical important difference corresponded to an increase of 7.1 percentile points. Standardized effect size of the Numeric Pain Rating Scale was 0.72, Guyatt responsiveness index was 2.2, area under the curve was 0.80 (95% confidence interval: 0.70, 0.92), and the minimum clinical important difference corresponded to a decrease of 1.16 points. CONCLUSION Information from this study may be helpful to therapists when evaluating the effectiveness of rehabilitation intervention on physical function and pain, and to power future clinical trials on patients with patellofemoral pain.
A coding polymorphism of the kallikrein 1 gene is associated with essential hypertension: a tagging SNP-based association study in a Chinese Han population

Objective The aim of this study was to investigate the association between common variants in the human tissue kallikrein 1 (KLK1) gene and susceptibility to essential hypertension in Chinese Han. Methods A tagging single nucleotide polymorphism (tSNP) approach was used for a case–control study in 2411 patients with essential hypertension and 2348 controls. All DNA samples and clinical data were collected from the International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Results Based on the HapMap data of Han Chinese in Beijing (CHB) population, two non-synonymous polymorphisms, namely rs5517 (Glu162Lys) and rs5516 (Gln121Glu), were selected as tSNPs which could efficiently tag eight SNPs of the KLK1 gene with R2 larger than 90% for both haplotypes and single locus. Significant differences were found between groups for frequencies of rs5517 A allele (42.48% in cases versus 39.32% in controls, P = 0.0019) and AA genotype [adjusted odds ratio (OR) = 1.25 for AA versus AG/GG, P = 0.0067]. The haplotype composed of the rs5517 A and rs5516 G allele significantly increased the risk of hypertension, with adjusted OR of 1.12 [95% confidence interval (CI), 1.04–1.28, P = 0.0377] when compared with the common haplotype G–C. Diplotype analysis also showed a significant association between the diplotype of AG–AC and essential hypertension (OR = 1.34, 95% CI, 1.07–1.68, P = 0.0096). Conclusions The present study suggested that rs5517 in the KLK1 gene was significantly associated with essential hypertension in a Chinese Han population.
Femtosecond laser keratome creation of partial thickness donor corneal buttons for lamellar keratoplasty.

PURPOSE To evaluate the thickness and diameter accuracy of the IntraLase femtosecond laser in harvesting corneal discs for lamellar keratoplasty. The stromal bed quality of resected corneas was evaluated by scanning electron microscopy. METHODS Two IntraLase units were used to create corneal discs at 225-, 300-, 400-, and 500-microm thickness settings and 7-, 8-, 8.5-, and 9-mm diameter settings (n = 28). Achieved thickness was measured using a digital caliper and achieved diameter was measured using imaging software. Samples were preserved and processed for scanning electron microscopy to observe stromal bed quality. RESULTS On both units, the mean deviation from attempted thickness was -9.5 +/- 8.6 microm (range: +6 to -28 microm). All of the obtained corneal discs were circular (horizontal versus vertical diameters, P > .05). The raster pattern produced a smoother stromal bed compared to the spiral pattern. CONCLUSIONS The IntraLase femtosecond laser keratome provides depth and diameter accuracy even at increased depth settings. Stromal bed was smooth with the raster pattern and can further be smoothed by excimer phototherapeutic keratectomy treatment. Femtosecond laser lamellar keratoplasty is a promising procedure and clinical data are needed to determine effectiveness.
The role of parenting styles and socio-economic status in parents’ knowledge of child development

Early childhood development (ECD) has been recognised to be the most important contributor to long-term social and emotional development. Therefore, positive parenting is paramount to foster quality parent–child interaction. Previous research shows that for parents to adopt a positive parenting style, some degree of parental knowledge is required. The aim of this study was to compare the relationship between knowledge of child development and parenting styles in low and high socio-economic groups of parents in ECD centres. A cross-sectional study was conducted using a correlation-comparative research design. The sample consisted of N = 140 parents with children between two and five years old from low and high socio-economic groups. Descriptive statistics and Pearson correlation were used to analyse the data. The findings also show that there is no correlation between knowledge of child development and authoritative parenting styles. However, correlations do exist between the other variables.