Miracle-dz/UniFAR-FTUs huggingface dataset:
Repeated-root constacyclic codes of length 2ℓmpn

For any different odd primes $\ell$ and $p$, structure of constacyclic codes of length $2\ell^mp^n$ over a finite field $\mathbb F_q$ of characteritic $p$ and their duals is established in term of their generator polynomials. Among other results, all linear complimentary dual and self-dual constacyclic codes of length $2\ell^mp^n$ over $\mathbb F_q$ are obtained.
A Hypomorphic Allele of Aryl Hydrocarbon Receptor-Associated Protein-9 Produces a Phenocopy of the Ahr-Null Mouse

The aryl hydrocarbon receptor-associated protein-9 (ARA9) is a chaperone of the aryl hydrocarbon receptor (AHR). The AHR has been shown to play a late developmental role in the normal closure of a fetal hepatovascular shunt known as the ductus venosus (DV). Given that Ara9-null mice display early embryonic lethality, we generated a hypomorphic Ara9 allele (designated Ara9fxneo) that displays reduced ARA9 protein expression. In an effort to demonstrate the role of ARA9 protein in AHR-mediated DV closure, we used combinations of Ara9 wild-type [Ara9(+/+)], null [Ara9(-/-)], and hypomorphic [Ara9(fxneo/fxneo)] alleles to produce mice with a graded expression of the ARA9 protein. Liver perfusion studies demonstrated that although none of the Ara9(+/+) mice displayed a patent DV, the shunt was observed in 10% of the Ara9(+/fxneo) mice, 55% of the Ara9(+/-) mice, and 83% of the Ara9(fxneo/fxneo) mice. That expression level of ARA9 correlates with the frequency of a phenocopy of the Ahr-null allele supports the conclusion that the ARA9 protein is essential for AHR signaling during development.
Differential Host Cell Gene Expression and Regulation of Cell Cycle Progression by Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus

Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) is a viral endoribonuclease with an unknown function. The regulation of cellular gene expression by nsp11 was examined by RNA microarrays using MARC-nsp11 cells constitutively expressing nsp11. In these cells, the interferon-β, interferon regulatory factor 3, and nuclear factor-κB activities were suppressed compared to those of parental cells, suggesting that nsp11 might serve as a viral interferon antagonist. Differential cellular transcriptome was examined using Affymetrix exon chips representing 28,536 transcripts, and after statistical analyses 66 cellular genes were shown to be upregulated and 104 genes were downregulated by nsp11. These genes were grouped into 5 major signaling pathways according to their functional relations: histone-related, cell cycle and DNA replication, mitogen activated protein kinase signaling, complement, and ubiquitin-proteasome pathways. Of these, the modulation of cell cycle by nsp11 was further investigated since many of the regulated genes fell in this particular pathway. Flow cytometry showed that nsp11 caused the delay of cell cycle progression at the S phase and the BrdU staining confirmed the cell cycle arrest in nsp11-expressing cells. The study provides insights into the understanding of specific cellular responses to nsp11 during PRRSV infection.
Ovarian stimulation by clomiphene citrate and hMG in combination with cetrorelix acetate for ICSI cycles.

BACKGROUND The introduction of GnRH antagonists such as cetrorelix acetate has made possible the simplification of ovarian stimulation. However, the most effective protocol for their administration has not yet been clearly defined. METHODS Forty women with male-factor infertility undergoing 40 ICSI cycles were included in the study. Clomiphene citrate at 100 mg a day was given from cycle day 3 through day 7. hMG at 150 IU was given on cycle days 4, 6 and 8, and was adjusted from day 9 according to the follicular and hormone responses. Cetrorelix acetate at 2.5 mg was administered when the leading follicle reached 14 mm. The remaining 0.5 mg was divided into two 0.25 mg injections for possible later use. Serum FSH, LH, estradiol and progesterone levels were measured daily from the day of cetrorelix acetate injection until hCG was given. RESULTS Serum LH level was suppressed effectively for 4 days. Four patients (10%) needed one or two additional injections of 0.25 mg cetrorelix acetate. No premature LH surge was detected in any of the women treated. Sixteen women became pregnant (40%), of which 14 pregnancies (35%) were ongoing at the time of writing. CONCLUSIONS This study demonstrates that this new protocol is feasible for couples with male-factor infertility undergoing ICSI.
Joint estimation of carrier frequency offset and statistical parameters of the multipath fading channel

In this paper, we focus on the joint estimation of the carrier frequency offset and statistical parameters of the multipath mobile channel. By modeling the multipath fading channel with a complex bandpass autoregressive (AR) model, we show how the estimates for the frequency offset, Doppler spread, and power profile of the multipath channel can be extracted from the estimated complex AR coefficients obtained via the expectation-maximization algorithm. A main advantage of the proposed joint estimator is that while it has a capability of performing equally well in all scattering environments, it can provide accurate estimates even in high-mobility channel conditions. We also demonstrate how the complexity of the estimator can be significantly reduced, while only slightly trading off performance, by applying the mean field approximation technique. Moreover, we derive a fully adaptive joint synchronization and channel-estimation scheme, as well as a novel Kalman-smoother-based frequency-error detector that can be used in feedback frequency-recovery schemes and is particularly well suited for fast-fading channel conditions. Finally, we revisit the Cramer-Rao lower bound analysis, and show how the Fisher information matrix can be conveniently computed in the presence of a frequency-selective Rayleigh fading channel
On the Difficulty of Clustering Microblog Texts for Online Reputation Management

In recent years microblogs have taken on an important role in the marketing sphere, in which they have been used for sharing opinions and/or experiences about a product or service. Companies and researchers have become interested in analysing the content generated over the most popular of these, the Twitter platform, to harvest information critical for their online reputation management (ORM). Critical to this task is the efficient and accurate identification of tweets which refer to a company distinguishing them from those which do not. The aim of this work is to present and compare two different approaches to achieve this. The obtained results are promising while at the same time highlighting the difficulty of this task.
Smoking and mortality from esophageal cancer in China: A large case‐control study of 19,734 male esophageal cancer deaths and 104,846 living spouse controls

An innovative population‐based case‐control study was conducted in a national mortality survey to assess the hazards of tobacco use on esophageal cancer among Chinese men. Cases were 19,734 males aged 35 years or older, who died of esophageal cancer during 1986–1988. Controls were 104,846 male living spouses of the same age when their wife died (of any cause) during the same period in the same county or city. The absolute esophageal cancer death rates were higher in smokers than those in nonsmokers in all geographical groups. The relative risks for esophageal cancer were 1.88 (95% CI: 1.73–2.05) and 1.39 (95% CI: 1.28–1.50) in urban and rural men, respectively, after adjustment for other relevant covariates including age group (5 years) and locality. When the calculation was restricted to men aged 35–69, the risk ratios for current cigarette smokers increased significantly with increasing number of cigarettes smoked daily and duration of smoking. Tobacco use, in any form, is an important risk factor for esophageal cancer in Chinese men. Selecting living spouses as controls is a unique and useful approach in the design of case‐control studies of cigarette smoking. © 2006 Wiley‐Liss, Inc.
Do Stock Market Liberalizations Cause Investment Booms ?

Stock market liberalizations lead private investment booms. In a sample of 11 developing countries that liberalized their stock markets, 9 experience growth rates of private investment above their non-liberalization median in the first year after liberalizing. In the second and third years after liberalization, this number is 10 of 11 and 8 of 11, respectively. The mean growth rate of private investment in the three years immediately following stock market liberalization exceeds the sample mean by 22 percentage points. The evidence stands in sharp contrast to recent work that suggests capital account liberalization has no effect on investment. JEL classification: F3, F4, G15
Release of peptide YY by neurotransmitters and gut hormones in the isolated, vascularly perfused rat colon.

BACKGROUND Peptide YY (PYY) is promptly released from endocrine cells of the distal part of the gut after food intake. To test the possibility that hormones produced by the proximal small intestine or transmitters of the enteric nervous system may take part in the early phase of meal-induced PYY release, various regulatory peptides and neurotransmitters of the gut were administered intra-arterially in the isolated, vascularly perfused rat colon. METHODS A colonic loop was perfused with a Krebs-Henseleit buffer containing 20% washed bovine erythrocytes via the superior mesenteric artery. The release of PYY in portal effluent was measured by radioimmunoassay. RESULTS Cholecystokinin and secretin produced a small release of PYY. In contrast, infusion of gastric inhibitory polypeptide (GIP) over the concentration range 0.25-1 nM for 30 min produced a dose-dependent secretion of PYY with a maximal response at 800% above basal. Tetrodotoxin (TTX) did not modify the GIP-induced PYY release. Bethanechol (10(-5) M, 10(-4) M) produced a PYY release that was maximal at the end of the 30-min infusion period. The beta-adrenergic agonist isoproterenol (10(-7) M, 10(-6) M) caused a prompt release of PYY, followed by a sustained release at a lower value. Calcitonin gene-related peptide (CGRP) (5.10(-9) M and 5.10(-8) M) induced a PYY release with kinetics similar to that found for isoproterenol. Finally, bombesin (10(-9)-10(-7) M) provoked a dose-dependent release of PYY, consisting of an early peak followed by a sustained response. TTX did not modify the bethanechol-, isoproterenol-, CGRP-, and bombesin-induced PYY secretion. CONCLUSION The hormonal peptide GIP and several transmitters of the nervous enteric system may mediate the release of PYY through the occupation of receptors possibly located at the surface of the colonic L-cells.
PHENOMENOLOGICAL STUDY OF LATE-ONSET SCHIZOPHRENIA

The phenomenological presentation of late-onset schizophrenia is a topic of considerable debate. This study aims to look at the clinical presentation of late-onset schizophrenia. Charts of all subjects who received a diagnosis of schizophrenia between January 1990 and December 1993 with age of onset being 45 or more were systematically analysed using the OPCRIT checklist. Of the 89 subjects chosen for analysis, 59 satisfied the ICD-10 DCR criteria for schizophrenia and formed the sample of the study. Of them, 20 were males and 39 were females. The mean age of onset for males was 51.6±5.7 years and for females, 53.2±16.7 years. The commonest phenomenon was persecutory delusion (83%) followed by delusion of influence and hallucinations in any modality (66%each). 53% of the subjects had third person auditory hallucinations, while 42% showed negative symptoms. Delusional perception and thought echo were not found in any subject. The implications of these phenomenological findings are discussed.
Differential role of CSF alpha-synuclein species, tau, and Aβ42 in Parkinson's Disease

There is a great interest in developing cerebrospinal fluid (CSF) biomarkers for diagnosis and prognosis of Parkinson's disease (PD). CSF alpha synuclein (α-syn) species, namely total and oligomeric α-syn (t-α-syn and o-α-syn), have shown to be of help for PD diagnosis. Preliminary evidences show that the combination of CSF t-α-syn and classical Alzheimer's disease (AD) biomarkers—β-amyloid 1–42 (Aβ42), total tau (t-tau), phosphorylated tau (p-tau)—differentiate PD patients from controls, and that reduced levels of Aβ42 represent a predictive factor for development of cognitive deterioration in PD. In this prospective study carried out in 44 PD patients and 25 neurological controls we wanted to verify whether the combination of CSF α-synuclein species—t-α-syn and o-α-syn—and classical AD biomarkers may help in differentiating PD from neurological controls, and if these biomarkers may predict cognitive decline. The median of follow-up duration was 3 years (range: 2–6 years). Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) were used for monitoring cognitive changes along time, being administered once a year. Oligo/total α-syn ratio (o/t-α-syn ratio) confirmed its diagnostic value, significantly contributing to the discrimination of PD from neurological controls. A greater diagnostic accuracy was reached when combining o/t-α-syn and Aβ42/tau ratios (Sens = 0.70, Spec = 0.84, AUC = 0.82; PPV = 0.89, NPV = 0.62, LR+ = 4.40, DOR = 12.52). Low CSF Aβ42 level was associated with a higher rate of MMSE and MoCA decline, confirming its role as independent predictive factor for cognitive decline in PD. None of the other biomarkers assessed (t-tau, p-tau, t-α-syn and o-α-syn) showed to have prognostic value. We conclude that combination of CSF o/t-α-syn and Aβ42/tau ratios improve the diagnostic accuracy of PD. PD patients showing low CSF Aβ42 levels at baseline are more prone to develop cognitive decline.
A Direct Integral Decomposition of the Wavelet Representation

In this paper we use the concept of wavelet sets, as introduced by X. Dai and D. Larson, to decompose the wavelet representation of the discrete group associated to an arbitrary n×n integer dilation matrix as a direct integral of irreducible monomial representations. In so doing we generalize a result of F. Martin and A. Valette in which they show that the wavelet representation is weakly equivalent to the regular representation for the Baumslag-Solitar groups.
ISPRS Journal of Photogrammetry and Remote Sensing

A wide range of methods for analysis of airborne-and satellite-derived imagery continues to be proposed and assessed. In this paper, we review remote sensing implementations of support vector machines (SVMs), a promising machine learning methodology. This review is timely due to the exponentially increasing number of works published in recent years. SVMs are particularly appealing in the remote sensing field due to their ability to generalize well even with limited training samples, a common limitation for remote sensing applications. However, they also suffer from parameter assignment issues that can significantly affect obtained results. A summary of empirical results is provided for various applications of over one hundred published works (as of April, 2010). It is our hope that this survey will provide guidelines for future applications of SVMs and possible areas of algorithm enhancement. © 2010 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS). Published by
Characterization of H5N1 Influenza Viruses That Continue To Circulate in Geese in Southeastern China

ABSTRACT The H5N1 influenza virus, which killed humans and poultry in 1997, was a reassortant that possibly arose in one type of domestic poultry present in the live-poultry markets of Hong Kong. Given that all the precursors of H5N1/97 are still circulating in poultry in southern China, the reassortment event that generated H5N1 could be repeated. Because A/goose/Guangdong/1/96-like (H5N1; Go/Gd) viruses are the proposed donors of the hemagglutinin gene of the H5N1 virus, we investigated the continued circulation, host range, and transmissibility of Go/Gd-like viruses in poultry. The Go/Gd-like viruses caused weight loss and death in some mice inoculated with high virus doses. Transmission of Go/Gd-like H5N1 viruses to geese by contact with infected geese resulted in infection of all birds but limited signs of overt disease. In contrast, oral inoculation with high doses of Go/Gd-like viruses resulted in the deaths of up to 50% of infected geese. Transmission from infected geese to chickens occurred only by fecal contact, whereas transmission to quail occurred by either aerosol or fecal spread. This difference is probably explained by the higher susceptibility of quail to Go/Gd-like virus. The high degree of susceptibility of quail to Go/Gd (H5N1)-like viruses and the continued circulation of H6N1 and H9N2 viruses in quail support the hypothesis that quail were the host of origin of the H5N1/97 virus. The ease of transmission of Go/Gd (H5N1)-like viruses to land-based birds, especially quail, supports the wisdom of separating aquatic and land-based poultry in the markets in Hong Kong and the need for continued surveillance in the field and live-bird markets in which different types of poultry are in contact with one another.
XPath query containment

Consider an XML publish-subscribe scenario with hundreds of subscribers and tens of thousands of XML documents to be delivered per day. Subscribers specify the documents in which they are interested in by means of XPath [8] expressions. If an expression matches a (part of a) document it is delivered to the subscriber. Naturally, it is desired that the decision to which subscriber a document must be sent should be taken quickly. Although the test whether a single XPath expression matches can be done in polynomial time, it is not efficient to test every such expression for every document. Fortunately, there is a partial order on expressions, i.e., for some expressions p, q it might hold that whenever a document matches p it also matches q (denoted p ⊆0 q). If we already know that a document matches p, we do not need to test q anymore, as it matches automatically. Correspondingly, if we know that q does not match then p will not match either. Hence, the inclusion structure of the XPath expressions should be computed in advance to decrease online computation time. This leads to the algorithmic problem of XPath Query Containment, i.e., checking whether p ⊆0 q (for a different, indexbased approach see, e.g., [6]). The main idea of this article is to describe some of the main algorithmic techniques that have been proposed for XPath Query Containment. These techniques are described in Section 5. Before that, in Sections 2 and 3 the basic definitions on XPath and the
Severe imported malaria in children in France. A national retrospective study from 1996 to 2005

Backgrounds Malaria is a leading cause of imported febrile illnesses in pediatric travelers, but few studies have addressed severe imported pediatric malaria. We aimed to determine the risk factors and the features of imported pediatric severe malaria. Methods We conducted a retrospective, descriptive study using the French National Reference Center for Imported Malaria database, in children aged 0–15 years who were hospitalized with a falciparum malaria from January 1st 1996 to December 31th 2005. Uncomplicated and severe cases of falciparum malaria were compared to identify risk factors for severe cases. In the hospitals that reported more than five severe cases during the study period, we evaluated severe cases for prognostic factors and assessed the accuracy WHO criteria for predicting severity. Given the rarity of deaths, adverse outcomes were defined as requiring major therapeutic procedures (MTPs)—e.g., sedation, mechanical ventilation, nasal oxygen therapy, blood transfusions, hemodialysis, fluid resuscitation—or pediatric intensive care unit (PICU) admission. Results Of 4150 pediatric malaria cases included in the study, 3299 were uncomplicated and 851 (20.5%) were severe. Only one death was recorded during this period. Predictors for severe falciparum malaria were: age <2 years (OR = 3.2, 95% CI = 2.5–4.0, p <0.0001) and a travel in the Sahelian region (OR = 1.7, 95% CI = 1.3–2.0, p = 0.0001). Of 422 severe malaria cases, a stay in a Sahelian region, lack of chemoprophylaxis, age <2 years or thrombocytopenia <100 x 10^3/mm^3 predicted adverse outcomes. Except for the hyperparasitemia threshold of 4%, the main WHO 2000 criteria for severe malaria reliably predicted adverse outcomes. In our study, the threshold of parasitemia most predictive of a poor outcome was 8%. Conclusion In imported pediatric malaria, children younger than 2 years deserve particular attention. The main WHO 2000 criteria for severity are accurate, except for the threshold of hyperparasitemia, which should be revised.
Scientific Application Performance on Candidate PetaScale Platforms

After a decade where HEC (high-end computing) capability was dominated by the rapid pace of improvements to CPU clock frequency, the performance of next-generation supercomputers is increasingly differentiated by varying interconnect designs and levels of integration. Understanding the tradeoffs of these system designs, in the context of high-end numerical simulations, is a key step towards making effective petascale computing a reality. This work represents one of the most comprehensive performance evaluation studies to date on modern NEC systems, including the IBM Power5, AMD Opteron, IBM BG/L, and Cray X1E. A novel aspect of our study is the emphasis on full applications, with real input data at the scale desired by computational scientists in their unique domain. We examine six candidate ultra-scale applications, representing a broad range of algorithms and computational structures. Our work includes the highest concurrency experiments to date on five of our six applications, including 32K processor scalability for two of our codes and describe several successful optimizations strategies on BG/L, as well as improved X1E vectorization. Overall results indicate that our evaluated codes have the potential to effectively utilize petascale resources; however, several applications would require reengineering to incorporate the additional levels of parallelism necessary to achieve the vast concurrency of upcoming ultra-scale systems.
Certolizumab pegol for the treatment of Crohn’s disease

In this article we provide a contemporary overview of available clinical data on certolizumab pegol, a pegylated anti-tumor necrosis factor (TNF) alpha agent that comprises a uniquely small protein, and its emerging role as a therapy for Crohn’s disease (CD). The results from a comprehensive clinical trial program suggest that certolizumab pegol offers rapid and sustained remission of moderate to severe CD. Certolizumab pegol is an effective and well-tolerated therapy both in patients who have already received biologics and in patients who are anti-TNF naïve. Benefits of therapy include a stable dosing regimen, which allows for rapid induction of a clinical response followed by long-term maintenance of response and remission under one fixed dose. Treatment with certolizumab pegol has been shown to improve function and quality of life in patients with CD, and insights into the potential mechanisms by which certolizumab pegol effects a response in CD suggest that this agent may have the potential to slow or even modify disease progression. Early therapy is particularly effective and could help control CD progression and lessen the burden of disease on patients.