Miracle-dz/UniFAR-FTUs huggingface dataset:
THE CURIOUS CASE OF HD 41248. A PAIR OF STATIC SIGNALS BURIED BEHIND RED NOISE

Gaining a better understanding of the effects of stellar-induced radial velocity noise is critical for the future of exoplanet studies since the discovery of the lowest-mass planets using this method will require us to go below the intrinsic stellar noise limit. An interesting test case in this respect is that of the southern solar analog HD 41248. The radial velocity time series of this star has been proposed to contain either a pair of signals with periods of around 18 and 25 days, which could be due to a pair of resonant super-Earths, or a single and varying 25 day signal that could arise due to a complex interplay between differential rotation and modulated activity. In this work, we build up more evidence for the former scenario, showing that the signals are still clearly significant, even after more than 10 yr of observations, and they likely do not change in period, amplitude, or phase as a function of time, the hallmarks of static Doppler signals. We show that over the last two observing seasons, this star was more intrinsically active and the noise reddened, highlighting why better noise models are needed to find the lowest amplitude signals, in particular, models that consider noise correlations. This analysis shows that there is still sufficient evidence for the existence of two super-Earths on the edge of, or locked into, a 7:5 mean motion resonance orbiting HD 41248.
Biochemical and Phosphoproteomic Analysis of the Helix-Loop-Helix Protein E47

ABSTRACT Numerous in vitro as well as genetic studies have demonstrated that the activities of the E2A proteins are regulated at multiple levels, including modulation of DNA binding by the Id proteins, association with the transcriptional modulators p300 and ETO, and posttranslational modifications. Here, we use affinity purification of tagged E47 combined with mass spectrometry in order to show that E47 interacts with the entire ensemble of Id proteins, namely, Id1, Id2, Id3, and Id4. Furthermore, we find that the lysine-specific histone demethylase 1 (LSD1), the protein arginine N-methyltransferase 5 (PRMT5), the corepressor CoREST, and the chaperones of the 14-3-3 family associate with affinity-purified E47. We also identify a spectrum of amino acid residues in E47 that are phosphorylated, including an AKT substrate site. We did, however, find that mutation of the identified AKT substrate site by itself did not perturb B cell development. In sum, these studies show that the entire ensemble of Id proteins has the ability to interact with E47, identify factors that associate with E47, and reveal a spectrum of phosphorylated residues in E47, including an AKT substrate site.
Utilization and acceptance of virtual patients in veterinary basic sciences – the vetVIP-project

Context: In medical and veterinary medical education the use of problem-based and cased-based learning has steadily increased over time. At veterinary faculties, this development has mainly been evident in the clinical phase of the veterinary education. Therefore, a consortium of teachers of biochemistry and physiology together with technical and didactical experts launched the EU-funded project “vetVIP”, to create and implement veterinary virtual patients and problems for basic science instruction. In this study the implementation and utilization of virtual patients occurred at the veterinary faculties in Budapest, Hannover and Lublin. Methods: This report describes the investigation of the utilization and acceptance of students studying veterinary basic sciences using optional online learning material concurrently to regular biochemistry and physiology didactic instruction. The reaction of students towards this offer of clinical case-based learning in basic sciences was analysed using quantitative and qualitative data. Quantitative data were collected automatically within the chosen software-system CASUS as user-log-files. Responses regarding the quality of the virtual patients were obtained using an online questionnaire. Furthermore, subjective evaluation by authors was performed using a focus group discussion and an online questionnaire. Results: Implementation as well as usage and acceptance varied between the three participating locations. High approval was documented in Hannover and Lublin based upon the high proportion of voluntary students (>70%) using optional virtual patients. However, in Budapest the participation rate was below 1%. Due to utilization, students seem to prefer virtual patients and problems created in their native language and developed at their own university. In addition, the statement that assessment drives learning was supported by the observation that peak utilization was just prior to summative examinations. Conclusion: Veterinary virtual patients in basic sciences can be introduced and used for the presentation of integrative clinical case scenarios. Student post-course comments also supported the conclusion that overall the virtual cases increased their motivation for learning veterinary basic sciences.
JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications

Constitutive JAK-STAT pathway activation occurs in most myeloproliferative neoplasms as well as in a significant proportion of other hematologic malignancies, and is frequently a marker of poor prognosis. The underlying molecular alterations are heterogeneous as they include activating mutations in distinct components (cytokine receptor, JAK, STAT), overexpression (cytokine receptor, JAK) or rare JAK2 fusion proteins. In some cases, concomitant loss of negative regulators contributes to pathogenesis by further boosting the activation of the cascade. Exploiting the signaling bottleneck provided by the limited number of JAK kinases is an attractive therapeutic strategy for hematologic neoplasms driven by constitutive JAK-STAT pathway activation. However, given the conserved nature of the kinase domain among family members and the interrelated roles of JAK kinases in many physiological processes, including hematopoiesis and immunity, broad usage of JAK inhibitors in hematology is challenged by their narrow therapeutic window. Novel therapies are, therefore, needed. The development of more selective inhibitors is a questionable strategy as such inhibitors might abrogate the beneficial contribution of alleviating the cancer-related pro-inflammatory microenvironment and raise selective pressure to a threshold that allows the emergence of malignant subclones harboring drug-resistant mutations. In contrast, synergistic combinations of JAK inhibitors with drugs targeting cascades that work in concert with JAK-STAT pathway appear to be promising therapeutic alternatives to JAK inhibitors as monotherapies.
Beamforming Based Receiver Scheme for DVB-T2 System in High Speed Train Environment

In this paper, the received signal from the different base stations (BSs) of the second generation of Terrestrial Digital Video Broadcasting (DVB-T2) in the high-speed-train (HST) scenario is modeled as a fast time-varying signal with the multiple Doppler frequency offsets. The interference caused by the multiple Doppler frequency offsets and the channel variations, and the signal to interference plus noise ratio of the received signal, are derived for the DVB-T2 receiver. The results of the theoretical analysis show that the interference greatly degraded the performance of the DVB-T2 system. To suppress the interference, we proposed a beamforming based receiver scheme for DVB-T2 system. By using the new signal processing scheme for the received signal vector from the antenna array, one can separate the received signal with the multiple Doppler frequency offsets into the multiple signals, each of which is with a single Doppler frequency offset. The separated signals are compensated by the corresponding Doppler frequency offsets and equalized by the estimated channel responses respectively, then combined into a signal to be demodulated. The results of the simulation show that the proposed scheme can effectively suppress the interference and greatly improve the performance of the DVB-T2 system in the HST environment.
The relationship between drainage density, erosion rate, and hilltop curvature: Implications for sediment transport processes

Drainage density is a fundamental landscape metric describing the extent of the fluvial network. We compare the relationship between drainage density (Dd) and erosion rate (E) using the Channel‐Hillslope Integrated Landscape Development (CHILD) numerical model. We find that varying the channel slope exponent (n) in detachment‐limited fluvial incision models controls the relationship between Dd and E, with n > 1 resulting in increasing Dd with E if all other parameters are held constant. This result is consistent when modeling both linear and nonlinear hillslope sediment flux. We also test the relationship between Dd and E in five soil‐mantled landscapes throughout the USA: Feather River, CA; San Gabriel Mountains, CA; Boulder Creek, CO; Guadalupe Mountains, NM; and Bitterroot National Forest, ID. For two of these field sites we compare Dd to cosmogenic radionuclide (CRN)‐derived erosion rates, and for each site we use mean hilltop curvature as a proxy for erosion rate where CRN‐derived erosion rates are not available. We find that there is a significant positive relationship between Dd, E, and hilltop curvature across every site, with the exception of the San Gabriel Mountains, CA. This relationship is consistent with an n exponent greater than 1, suggesting that at higher erosion rates, the transition between advective and diffusive processes occurs at smaller contributing areas in soil‐mantled landscapes.
Transition from Student to Practitioner: The Role of Expectations, Values and Personality

Research into occupational therapy job satisfaction has been driven largely by concerns regarding recruitment and retention. There is a need to develop more robust theoretically sound methodologies for the investigation of job satisfaction within the profession. This article presents the initial findings of a national longitudinal study of Australian occupational therapists. The respondents (n=295) were investigated immediately prior to graduation with respect to their expectations about working as an occupational therapist, their work values and their work preferences. A personality profile was also administered. The findings indicate that students hold inflated expectations about their first job and retain traditional occupational therapy work values. Demographic and personality profiles reflect those of the international student body and can assist in the prediction of student expectations.
A Theoretical Investigation of the Psychoanalytic Process Working Through

This thesis theoretically investigated the psychoanalytic process working through with the purpose of clarifying and refining the concept. The literature on working through and its elements, resistance and interpretation was examined. The concepts of working through of the school of ego psychology, the school of object relations and the school of self psychology were compared. Theoretical analysis involved explaining the working through process by simple analogy. My findings were that working through decreases the patient‟s defensive anxieties through the medium of words. This explanation applies to all three schools. In addition, a model of psychic development was derived, which integrates the theories of the ego school, the object relations school, and the school of self psychology.
Three-Point Statistics from a New Perspective

The multipole expansion of spatial three-point statistics is introduced as a tool for investigating and displaying configuration dependence. The novel parameterization renders the relation between bispectrum and three-point correlation function especially transparent as a set of two-dimensional Hankel transforms. It is expected on theoretical grounds that three-point statistics can be described accurately with only a few multipoles. In particular, we show that in the weakly nonlinear regime, the multipoles of the reduced bispectrum, Ql, are significant only up to quadrupole. Moreover, the nonlinear bias in the weakly nonlinear regime only affects the monopole order of these statistics. As a consequence, a simple, novel set of estimators can be constructed to constrain galaxy bias. In addition, the quadrupole to dipole ratio is independent of the bias; thus, it becomes a novel diagnostic of the underlying theoretical assumptions: weakly nonlinear gravity and perturbative local bias. To illustrate the use of our approach, we present predictions based on both power-law and cold dark matter models. We show that the presently favored Sloan Digital Sky Survey/Wilkinson Microwave Anisotropy Probe concordance model displays strong "baryon bumps" in the Ql's. Finally, we sketch out three practical techniques to estimate these novel quantities: they amount to new, and for the first time edge-corrected, estimators for the bispectrum.
Hemifield pattern electroretinogram in ocular hypertension: comparison with frequency doubling technology and optical coherence tomography to detect early optic neuropathy

Background To assess the sensitivity and specificity of hemifield pattern electroretinogram (HF-PERG) for detecting early retinal ganglion cell (RGC) damage in ocular hypertensive (OH) patients. Methods Fifty-two OH patients (mean age 56±9.6 years) with an intraocular pressure (IOP) . 21 mmHg were assessed. All subjects underwent HF-PERG, optical coherence tomography (OCT), and frequency doubling technology (FDT) visual field. Results OH patients showed a significant increase of peak-time of the N95 (P=0.027) compared to controls. The amplitude of the N95 of the lower and upper HF-PERG showed significant differences (P=0.037 and P=0.023, respectively) between the two groups. A significant intraocular (P=0.006) and interocular (P=0.018) asymmetry of N95 amplitude was found. Receiver operating characteristic (ROC) curve analysis revealed a sensitivity of 93% for the N95 of the lower HF-PERG, whereas full-field pattern electroretinogram (PERG) N95 peak-time had a sensitivity of 88%. In OH patients, we found a thinning of OCT - retinal nerve fiber layer (RNFL), especially in the superior and inferior quadrant, although not statistically significant, and a significantly higher FDT pattern standard deviation (FDT-PSD; P=0.001). In the OCT-RNFL inferior quadrant, a sensitivity of 82% was recorded. Finally, the sensitivity of the FDT-PSD was 92%. Conclusion Our study shows that HF-PERG is a very sensitive test for detecting early damage of the RGC.
Cerebrospinal fluid manifestations of the neurologic complications of human immunodeficiency virus infection.

Cerebrospinal fluid (CSF) cytology, white blood cell (WBC) count and protein were evaluated in 32 human immunodeficiency virus (HIV)-infected patients with the acquired immune deficiency syndrome (AIDS) or an AIDS-related complex who manifested a variety of neurologic symptoms. Of 17 patients with AIDS-related encephalitis (ARE), 13 had hypocellular CSFs; elevated WBCs and pleocytosis were noted in 4, multinucleated giant cells in 2 and elevated CSF protein was found in 4 of 8 specimens tested. Three patients with central nervous system (CNS) toxoplasmosis had unremarkable CSF cytology findings, but all had elevated CSF proteins. In five patients with cryptococcal meningitis, cytologic examinations demonstrated organisms in four and elevated proteins in three. Of five patients with primary CNS lymphomas, one had cytology positive for large cell lymphoma; two showed suspicious cells and two manifested "atypical lymphocytes. " Elevated CSF protein was present in four. Other conditions observed included progressive multifocal leukoencephalopathy, tubercular meningitis and cytomegaloviral (CMV) meningitis or encephalitis. Twenty-five percent of patients with ARE manifested pleocytosis with multinucleated giant cells; pleocytosis with CMV inclusions was noted in a CMV viral radiculitis. The CSF cytologic examination in HIV-infected patients with neurologic complications seems helpful in diagnosing cryptococcal meningitis and lymphoma, but less so for diagnosing toxoplasmosis.
Prevention of obesity: a review of interventions

This paper was commissioned by the Foresight programme of the Office of Science and Innovation, Department of Trade and Industry © 2007 Queen’s Printer and Controller of HMSO; published with permission Journal compilation © 2007 The International Association for the Study of Obesity. obesity reviews 8 (Suppl. 1) , 127–130 127 OnlineOpen: This article is available free online at www.blackwell-synergy.com Blackwell Publishing LtdOxford, UKOBRObesity Reviews1467-7881© 2007 Queen's Printer and Controller of HMSO; published with permission; Journal compilation © 2007 The International Association for the Study of Obesity ? 2007 8 127130 Review Article Prevention of obesity T. Brown et al.
Autophagosome–lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome

Autophagy is a multistep membrane traffic pathway. In contrast to autophagosome formation, the mechanisms underlying autophagosome–lysosome fusion remain largely unknown. Here, we describe a novel autophagy regulator, inositol polyphosphate‐5‐phosphatase E (INPP5E), involved in autophagosome–lysosome fusion process. In neuronal cells, INPP5E knockdown strongly inhibited autophagy by impairing the fusion step. A fraction of INPP5E is localized to lysosomes, and its membrane anchoring and enzymatic activity are necessary for autophagy. INPP5E decreases lysosomal phosphatidylinositol 3,5‐bisphosphate (PI(3,5)P2), one of the substrates of the phosphatase, that counteracts cortactin‐mediated actin filament stabilization on lysosomes. Lysosomes require actin filaments on their surface for fusing with autophagosomes. INPP5E is one of the genes responsible for Joubert syndrome, a rare brain abnormality, and mutations found in patients with this disease caused defects in autophagy. Taken together, our data reveal a novel role of phosphoinositide on lysosomes and an association between autophagy and neuronal disease.
Reliability-Centered Maintenance of the Electrically Insulated Railway Joint via Fault Tree Analysis: A Practical Experience Report

Maintenance is an important way to increase system dependability: timely inspections, repairs and renewals can significantly increase a system's reliability, availability and life time. At the same time, maintenance incurs costs and planned downtime. Thus, good maintenance planning has to balance between these factors. In this paper, we study the effect of different maintenance strategies on the electrically insulated railway joint (EI-joint), a critical asset in railroad tracks for train detection, and a relative frequent cause for train disruptions. Together with experts in maintenance engineering, we have modeled the EI-joint as a fault maintenance tree (FMT), i.e. a fault tree augmented with maintenance aspects. We show how complex maintenance concepts, such as condition-based maintenance with periodic inspections, are naturally modeled by FMTs, and how several key performance indicators, such as the system reliability, number of failures, and costs, can be analysed. The faithfulness of quantitative analyses heavily depend on the accuracy of the parameter values in the models. Here, we have been in the unique situation that extensive data could be collected, both from incident registration databases, as well as from interviews with domain experts from several companies. This made that we could construct a model that faithfully predicts the expected number of failures at system level. Our analysis shows that that the current maintenance policy is close to cost-optimal. It is possible to increase joint reliability, e.g. by performing more inspections, but the additional maintenance costs outweigh the reduced cost of failures.
Effects of the infant stool color card screening program on 5‐year outcome of biliary atresia in taiwan

In Taiwan, a screening system using an infant stool color card to promote the early diagnosis of biliary atresia (BA) was established in 2002. This study aimed to investigate the 5‐year outcome of BA before and after using the screening program. BA patients were divided into three cohorts according to their birth dates. The patients in cohort A (n = 89) were born before the stool card screening program (1990‐2000); those in cohort B (n = 28) were screened by the stool card regional screening program (2002‐2003); and those in cohort C (n = 74) were screened by the stool card universal screening program (2004‐2005). The relative odds ratios were computed using logistic regression to compare the different factors affecting survival time. The rate of age at Kasai operation <60 days was 49.4% and 65.7% in cohorts A and B+C, respectively (P = 0.02). The jaundice‐free (total serum bilirubin <2.0 mg/dL) rate 3 months after surgery was 34.8% and 60.8% in cohorts A and B+C, respectively (P < 0.001). The 3‐year jaundice‐free survival rate with native liver was 31.5% in cohort A and 56.9% in cohort B+C (P < 0.001), whereas the 3‐year overall survival rates were 64.0% and 89.2%, respectively (P < 0.001). The 5‐year jaundice‐free survival rate with native liver was 27.3% in cohort A and 64.3% in cohort B (P < 0.001), and the 5‐year overall survival rates were 55.7% and 89.3%, respectively (P < 0.001). Conclusion: The stool color card screening program for BA allows for earlier Kasai operation, which increases the jaundice‐free rate at 3 months postsurgery. With higher surgical success rates, the 3‐ and 5‐year outcome of BA patients in Taiwan improves remarkably. (HEPATOLOGY 2011.)
Segregating the Neural Correlates of Physical and Perceived Change in Auditory Input using the Change Deafness Effect

Psychophysical experiments show that auditory change detection can be disturbed in situations in which listeners have to monitor complex auditory input. We made use of this change deafness effect to segregate the neural correlates of physical change in auditory input from brain responses related to conscious change perception in an fMRI experiment. Participants listened to two successively presented complex auditory scenes, which consisted of six auditory streams, and had to decide whether scenes were identical or whether the frequency of one stream was changed between presentations. Our results show that physical changes in auditory input, independent of successful change detection, are represented at the level of auditory cortex. Activations related to conscious change perception, independent of physical change, were found in the insula and the ACC. Moreover, our data provide evidence for significant effective connectivity between auditory cortex and the insula in the case of correctly detected auditory changes, but not for missed changes. This underlines the importance of the insula/anterior cingulate network for conscious change detection.