Miracle-dz/UniFAR-FTUs huggingface dataset:
Description of two novel members of the family Erysipelotrichaceae: Ileibacterium valens gen. nov., sp. nov. and Dubosiella newyorkensis, gen. nov., sp. nov., from the murine intestine, and emendation to the description of Faecalibaculum rodentium.

To better characterize murine intestinal microbiota, a large number (187) of Gram-positive-staining, rod- and coccoid-shaped, and facultatively or strictly anaerobic bacteria were isolated from small and large intestinal contents from mice. Based on 16S rRNA gene sequencing, a total 115 isolates formed three phylogenetically distinct clusters located within the family Erysipelotrichaceae. Group 1, as represented by strain NYU-BL-A3T, was most closely related to Allobaculum stercoricanis, with 16S rRNA gene sequence similarity values of 87.7 %. A second group, represented by NYU-BL-A4T, was most closely related to Faecalibaculum rodentium, with 86.6 % 16S rRNA gene sequence similarity. A third group had a nearly identical 16S rRNA gene sequence (99.9 %) compared with the recently described Faecalibaculum rodentium, also recovered from a laboratory mouse; however, this strain had a few differences in biochemical characteristics, which are detailed in an emended description. The predominant (>10 %) cellular fatty acids of strain NYU-BL-A3T were C16 : 0 and C18 : 0, and those of strain NYU-BL-A4T were C10 : 0, C16 : 0, C18 : 0 and C18 : 1ω9c. The two groups could also be distinguished by multiple biochemical reactions, with the group represented by NYU-BL-A4T being considerably more active. Based on phylogenetic, biochemical and chemotaxonomic criteria, two novel genera are proposed, Ileibacterium valens gen. nov., sp. nov. with NYU-BL-A3T (=ATCC TSD-63T=DSM 103668T) as the type strain and Dubosiella newyorkensis gen. nov., sp. nov. with NYU-BL-A4T (=ATCC TSD-64T=DSM 103457T) as the type strain.
Anticholinergic Exposure and Risk of Pneumonia in Persons with Alzheimer's Disease: A Nested Case-Control Study.

BACKGROUND Risk of pneumonia is increased in persons with Alzheimer's disease (AD). In some studies, anticholinergic drugs (AC) have been associated with an increased pneumonia risk. OBJECTIVE We analyzed the risk of pneumonia associated with ACs in persons with AD. METHODS We performed a nested case-control study using register-based data from a Finnish nationwide MEDALZ cohort including all community-dwelling persons diagnosed with AD during 2005-2011. Cases were identified based on pneumonia diagnoses (n = 12,442) from hospital discharge and causes of death registers. Up to two controls without pneumonia were matched based on time since AD diagnoses, age, and gender for each case; AC use was measured using Anticholinergic Drug Scale. RESULTS Use of AC was associated with an increased risk of pneumonia (adjusted odds ratio (OR) 1.36, 95% confidence interval (CI) 1.29-1.43). However, there was no increased pneumonia risk in persons using level 3 ACs. Incident use was associated with higher risk of pneumonia (OR 2.68, 95% CI 2.15-3.34) than prevalent use (OR 1.48, 95% CI 1.40-1.57). Among persons using cholinesterase inhibitors (AChEIs), risk of pneumonia was increased in persons using also ACs (OR 1.53, 95% CI 1.41-1.66). CONCLUSION ACs were associated with an increased risk of pneumonia in persons with AD, especially at the time of initiation of these drugs. AC use was associated with increased pneumonia risk also in persons using AChEIs. This risk should be carefully considered when treating AD patients.
Dietary patterns are associated with dietary recommendations but have limited relationship to BMI in the Communities Advancing the Studies of Tribal Nations Across the Lifespan (CoASTAL) cohort

Abstract Objective Traditional food systems in indigenous groups have historically had health-promoting benefits. The objectives of the present study were to determine if a traditional dietary pattern of Pacific Northwest Tribal Nations (PNwT) could be derived using reduced rank regression and if the pattern would be associated with lower BMI and current Dietary Reference Intakes. Design The baseline data from the Communities Advancing the Studies of Tribal Nations Across the Lifespan (CoASTAL) cohort were used to derive dietary patterns for the total sample and those with plausibly reported energy intakes. Setting Pacific Northwest Coast of Washington State, USA. Subjects Adult PNwT members of the CoASTAL cohort with laboratory-measured weight and height and up to 4 d of dietary records (n 418). Results A traditional dietary pattern did not evolve from the analysis. Moderate consumption of a sweet drinks dietary pattern was associated with lower BMI while higher consumption of a vegetarian-based dietary pattern was associated with higher BMI. The highest consumers of the vegetarian-based dietary pattern were almost six times more likely to meet the recommendations for dietary fibre. Conclusions Distinct dietary patterns were found. Further exploration is needed to confirm whether the lack of finding a traditional pattern is due to methodology or the loss of a traditional dietary pattern among this population. Longitudinal assessment of the CoASTAL cohort's dietary patterns needs to continue.
Transcatheter Aortic Valve Replacement in Patients with Cirrhosis

Patients with cirrhosis who undergo cardiac operation with extracorporeal circulation are at high risk for operative morbidity and mortality. Transcatheter aortic valve replacement (TAVR) can obviate the need for cardiopulmonary bypass and may reduce operative morbidity in comparison to standard aortic valve replacement (SAVR) in select patients.
p16/Ki-67 co-expression associates high risk human papillomavirus persistence and cervical histopathology: a 3-year cohort study in China

Purpose To evaluate the association of p16/Ki-67 co-expression and persistence of high-risk human papillomavirus (HR-HPV) infection as well as cervical abnormalities. Methods We performed a 3-year cohort study among which 2498 Chinese women aged 25 to 65 years were screened by different HPV tests in 2011. 690 women who were positive at any of the tests and a random sample of 164 women with all negative results received colposcopy, cervical specimens for cobas HPV test (Roche diagnostics) were collected before colposcopy; of this group, 737 cervical specimens were collected to perform cobas, Liquid-based cytology, HPV E6 test (Arbor Vita Corporation) and p16/Ki-67 dual staining (Roche diagnostics) in 2014. Colposcopy and biopsies was performed on women with any abnormal result. Results Compared to women without HR-HPV persistent infection, women in the HR-HPV persistence group had a higher risk of p16/Ki-67 positive, with an adjusted Odds Ratio(OR) and 95% confidence interval (CI) of 6.29 (4.07-9.72); moreover, adjusted odds ratio for women who had HPV16/18 persistent infection was nearly 4-folder higher than women with other 12 HR-HPV persistent infection (adjusted OR = 17.15, 95% CI: 7.11-41.33 vs adjusted OR = 4.68, 95% CI: 2.89-7.58). Additionally, p16/Ki-67 positivity rate significantly increased with the severity of the cytological and histological abnormalities, and resulted strongly associated with a CIN2+ diagnosis (OR = 16.03, 95% CI: 4.46-57.59). Conclusions p16/Ki-67 co-expressions associated strongly with HR-HPV persistence, especially with HPV16/18, and the presence of a CIN2+ lesion. Therefore, p16/Ki-67 could be considered as a suitable biomarker for cervical cancer screening, particularly in HPV-based screening programs.
A High-Performance Gate Engineered InGaN Dopingless Tunnel FET

A gate engineered InGaN dopingless tunnel FET (DL-TFET) using the charge plasma concept is proposed and investigated by silvaco Atlas simulation. In<sub>0.75</sub>Ga<sub>0.25</sub>N is a direct gap semiconductor, and the effective tunneling mass of electron and hole is smaller than that of silicon, which induces that the drain current and average subthreshold swing (SS<sub>avg</sub>) of InGaN DL-TFET improve <inline-formula> <tex-math notation="LaTeX">$\text {1.3}\times \text {10}^{\text {2}}$ </tex-math></inline-formula> times and 51.1% than that of Si DL-TFET at the overdrive voltage of 0.5 V, respectively. What is more, better device performances are achieved by gate engineering with appropriate “In” fraction, proper space between the gate and source (<inline-formula> <tex-math notation="LaTeX">${L}_{\text {gs}}$ </tex-math></inline-formula>), and appropriate tunneling gate work function (<inline-formula> <tex-math notation="LaTeX">$\Phi _{\text {TG}}$ </tex-math></inline-formula>). The direct-current, RF, and energy-efficient performance studies show that SS<sub>avg</sub> of 7.9 mV/dec, an on-state current (<inline-formula> <tex-math notation="LaTeX">${I}_{ \mathrm{\scriptscriptstyle ON}}$ </tex-math></inline-formula>) of <inline-formula> <tex-math notation="LaTeX">$\text {8.02} \times \text {10}^{-\text {5}}$ </tex-math></inline-formula> A/<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula>, a cutoff frequency (<inline-formula> <tex-math notation="LaTeX">${f}_{T}$ </tex-math></inline-formula>) of 119 GHz, and an energy delay product of 0.64 fJ-ps/<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula> can be obtained in the proposed TFET. This paper indicates that the gate engineered InGaN DL-TFET is a promising TFET for low-power RF and digital logic applications.
A systematic review on identifying risk factors associated with early sexual debut and coerced sex among adolescents and young people in communities

AIMS AND OBJECTIVES To review literature on identifying the risk factors associated with early sexual coerced debut with the aim to facilitate the healthcare workers' planning of relevant health services to improve intervention strategies for delaying of early coerced sexual debut or forced sexual debut (CSD/FSD) in the communities. BACKGROUND Identifying the risk factors associated with coercion at first sex is crucial for developing appropriate sexual and reproductive health information and health promotion in response. However, current knowledge about the risk factors associated with coercion, sexual debut (SD) and delayed SD among young people is limited. Health information programmes are important during adolescence, when young people are developing their values and beliefs about sexual activity and sexual norms. However, little is known about those risk factors on initiation of early sexual debut to plan relevant interventions that can delay SD and prevent CSD/FSD in this population. DESIGN A systematic review. METHODS An extensive literature search using MEDLINE (PubMed), Nursing Journals (PubMed), Web of Science, PsychINFO and CINAHL. RESULTS The search generated 39 published studies that met our inclusion and exclusion criteria. Thirty-two articles passed the quality appraisal and were selected. This review identified six domains of risk factors, categorised as: (1) the individual domain, (2) the family domain, (3) the partner/peer domain, (4) the school domain, (5) the community domain and (6) the cultural domain. These factors highlight the influences on sexual decision-making among adolescents and young people and the timing of their first sexual intercourse. CONCLUSION It is important to use the outcome of this review's categorisation of identified risk factors to facilitate the healthcare workers and plan relevant sexual and reproductive health programmes more accessible to adolescents, especially young females and their parents. There is a need to evaluate the impact of these programmes that can delay SD and prevent CSD/FSD in this population. RELEVANCE TO CLINICAL PRACTICE The results of this study could provide guidance on the planning of effective interventions for delaying of early CSD/FSD in the communities.
Comorbid persistent lower respiratory symptoms and posttraumatic stress disorder 5-6 years post-9/11 in responders enrolled in the World Trade Center Health Registry.

BACKGROUND Co-occurrence of lower respiratory symptoms (LRS) and posttraumatic stress disorder (PTSD) has been increasingly recognized among responders and survivors of the World Trade Center (WTC) disaster. Information is limited on the degree which comorbidity intensifies symptoms and compromises quality of life across exposed groups. METHODS Among responders who completed the first and second Registry surveys, measures of respiratory illness, psychological distress, and diminished quality of life were compared between responders comorbid for LRS and PTSD and responders with only LRS or PTSD. RESULTS Of 14,388 responders, 40% of those with LRS and 57% of those with PTSD were comorbid. When demographic and WTC exposure-related factors were controlled, comorbid responders compared to those with LRS alone were twice as likely to have frequent dyspnea and to have sought care for dyspnea. Compared to responders with PTSD alone, comorbid responders were 2.1 times more likely to report intense re-experiencing of the disaster, 2.5 times more likely to express feelings of significant non-specific psychological distress, and 1.4 times more likely to have received mental health care. Comorbid responders were approximately three times more likely to report only fair or poor general health and more than twice as likely to report being unable to perform usual activities for ≥14 of 30 days before interview. CONCLUSIONS Outcomes in comorbid responders were similar to or more severe than in comorbid survivors. Health care and disaster relief providers must suspect comorbid illness when evaluating responders' respiratory or mental illnesses and consider treatment for both.
Epoxy resin as a new alternative sorbent phase for stir bar sorptive extraction for the determination of triclosan and methyl-triclosan

ABSTRACT The main objective of this study is to propose a new sorbent phase based on a commercial epoxy resin, for use as an alternative sorbent in the stir bar sorptive extraction (SBSE) technique. The analytes triclosan (TCS) and methyl-triclosan (MTCS) were selected in order to demonstrate the application of the bars, using some water samples as matrices. The extraction conditions of sample volume, stirring time, pH, temperature and ionic strength were evaluated, and for the back extraction, the bars were sonicated using 1.00 mL of acetonitrile for 10 min. The technique of liquid chromatography using a diode array detector was employed for the quantitation. Analytical curves of between 2.50 and 50.0 μg L−1 with r2 of 0.9894 (TCS) and 0.9933 (MTCS), and limit of detection (LOD) values of 0.6 μg L−1 (TCS) and 2.0 μg L−1 (MTCS) were observed. Recovery values between 100.4% and 121.6% were verified for ultrapure water and between 50.3% and 93.8% for wastewater samples, thereby suggesting the possibility of employing the bars for quantitation of TCS and MTCS in aqueous samples. This is the first time that this resin has been applied without the need for the adhesion of any additional sorbent phase, thereby providing a simple and low-cost method. Another feature is that only eight bars were employed in the entire work, and each bar was used approximately 40 times with the same performance without memory effects.
A Comprehensive Review of Wireless Charging Technologies for Electric Vehicles

The profitable commercialization and fast adoption of electrified transportation require fast, economical, and reliable charging infrastructure. This paper provides a comprehensive, state-of-the-art review of all the wireless charging technologies for electric vehicle (EVs), characteristics and standards available in the open literature, as well as sustainable implications and potential safety measures. A comparative overview of conductive charging and wireless charging is followed by a detailed description of static wireless charging, dynamic wireless charging (DWC), and quasi-DWC. Roadblocks, such as coil design of power pads, frequency, power level limitations, misalignment, and potential solutions, are outlined. The standards are then tabulated to deliver a coherent view of the current status, followed by an explanation of the crux of these standards. Necessity and progress in the standardization of wireless charging systems are then deliberated. Vehicle-to-grid application of wireless charging is reviewed followed by an overview of economic analysis, social implications, the effect on sustainability, and safety aspects to evaluate the commercial feasibility of wireless charging. This paper will be highly beneficial to research entities, industry professionals, and investment representatives as a ready reference of the wireless charging system of EVs, with information on important characteristics and standards.
Study on Finite Element Model Updating in Highway Bridge Static Loading Test Using Spatially-Distributed Optical Fiber Sensors

A finite model updating method that combines dynamic-static long-gauge strain responses is proposed for highway bridge static loading tests. For this method, the objective function consisting of static long-gauge stains and the first order modal macro-strain parameter (frequency) is established, wherein the local bending stiffness, density and boundary conditions of the structures are selected as the design variables. The relationship between the macro-strain and local element stiffness was studied first. It is revealed that the macro-strain is inversely proportional to the local stiffness covered by the long-gauge strain sensor. This corresponding relation is important for the modification of the local stiffness based on the macro-strain. The local and global parameters can be simultaneously updated. Then, a series of numerical simulation and experiments were conducted to verify the effectiveness of the proposed method. The results show that the static deformation, macro-strain and macro-strain modal can be predicted well by using the proposed updating model.
Association Between Hyperreflective Dots on Spectral-Domain Optical Coherence Tomography in Macular Edema and Response to Treatment.

Purpose To investigate the association between hyperreflective dots (HRDs) on spectral-domain optical coherence tomography (SD-OCT) and response to intravitreal bevacizumab (IVB) or dexamethasone injection in eyes with diabetic macular edema (DME) or macular edema due to retinal vein occlusion (RVO). Methods A retrospective review was conducted involving patients with DME or macular edema due to RVO. Patients with treatment-naïve macular edema were initially treated with three consecutive IVB injections and classified based on the treatment response to bevacizumab. After three consecutive IVB injections, bevacizumab nonresponders were treated using dexamethasone implants and reclassified based on the treatment response. The best-corrected visual acuity, number of HRDs, and outer plexiform layer (OPL) disruptions were analyzed according to the treatment response. Results Eighty-two eyes with DME and 68 eyes with RVO were included in this study. Thirty-six (43.9%) eyes with DME and 22 (32.4%) eyes with RVO were bevacizumab nonresponders. The number of baseline HRDs in bevacizumab nonresponders (16.06 ± 6.60 in DME, 14.23 ± 4.09 in RVO) was significantly greater than that in responders (11.26 ± 3.64, P < 0.001 in DME, 11.17 ± 4.83, P = 0.013 in RVO), and it did not decrease after IVB injections. Unlike the response to bevacizumab, eyes that responded to dexamethasone implant but not to IVB had significantly more HRDs (19.56 ± 6.75) than eyes that did not respond (11.50 ± 3.78, P = 0.006). The OPL disruption rate was significantly higher in bevacizumab nonresponders than in responders (P < 0.001 in DME and P = 0.001 in RVO). Conclusions In patients with DME or macular edema due to RVO, the number of HRDs on SD-OCT may be a predictive indicator of the response to IVB injection or dexamethasone implant. In bevacizumab responders, the number of HRDs on SD-OCT was small. In contrast, more HRDs, which might reflect increased inflammation in the retina, were observed in dexamethasone responders. Therefore, dexamethasone implants might be more effective in DME or RVO eyes with multiple HRDs and OPL disruption on SD-OCT.
Complex permittivity measurements at Ka-Band using rectangular dielectric waveguide

The rectangular dielectric waveguide (RDWG) technique has been developed for the determination of the dielectric constant of materials from effective refractive index measurements in the Q and W bands. This paper describes the use of an optimization method in conjunction with the RDWG technique for the determination of both the dielectric constant and loss tangent of materials at Ka-Band. The effect of the uncertainty in the measured sample thickness is presented.
Bcl-2 delays cell cycle through mitochondrial ATP and ROS

ABSTRACT Bcl-2 inhibits cell proliferation by delaying G0/G1 to S phase entry. We tested the hypothesis that Bcl-2 regulates S phase entry through mitochondrial pathways. Existing evidence indicates mitochondrial adenosine tri-phosphate (ATP) and reactive oxygen species (ROS) are important signals in cell survival and cell death, however, the molecular details of how these 2 processes are linked remain unknown. In this study, 2 cell lines stably expressing Bcl-2, 3T3Bcl-2 and C3HBcl-2, and vector-alone PB controls were arrested in G0/G1 phase by serum starvation and contact inhibition, and ATP and ROS were measured during re-stimulation of cell cycle entry. Both ATP and ROS levels were decreased in G0/G1 arrested cells compared with normal growing cells. In addition, ROS levels were significant lower in synchronized Bcl-2 cells than those in PB controls. After re-stimulation, ATP levels increased with time, reaching peak value 1–3 hours ahead of S phase entry for both Bcl-2 cells and PB controls. Consistent with 2 hours of S phase delay, Bcl-2 cells reached ATP peaks 2 hours later than PB control, which suggests a rise in ATP levels is required for S phase entry. To examine the role of ATP and ROS in cell cycle regulation, ATP and ROS level were changed. We observed that elevation of ATP accelerated cell cycle progression in both PB and Bcl-2 cells, and decrease of ATP and ROS to the level equivalent to Bcl-2 cells delayed S phase entry in PB cells. Our results support the hypothesis that Bcl-2 protein regulates mitochondrial metabolism to produce less ATP and ROS, which contributes to S phase entry delay in Bcl-2 cells. These findings reveal a novel mechanistic basis for understanding the link between mitochondrial metabolism and tumor-suppressive function of Bcl-2.