Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic polymorphism of MTHFR A1298C and esophageal cancer susceptibility: a meta-analysis.

BACKGROUND Associations between the methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism and esophageal cancer risk have been reported in many articles recently, but results were controversial. Therefore the present meta-analysis was conducted to to provide a more precise estimation. METHODS Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. RESULTS Finally, six case- control studies involving a total of 1,302 cases and 2,391controls for the A1298C polymorphism were included. The meta-analysis showed that significantly increased risk for Asians (CC versus AA, OR=3.799, 95%CI=1.541-9.365, P=0.004; CCversusCA+AA, OR=3.997, 95%CI=1.614-9.900, P=0.003) and Caucasians (CC versus AA, OR=1.797, 95%CI=1.335-2.418, P=0.000; CC+CA versus AA,OR=1.240, 95%CI=1.031-1.492, P=0.022; CCversusCA+AA, OR=1.693, 95%CI=1.280-2.240, P=0.000). In addition, there was an association with risk for both ESCC (CC versus AA, OR=2.529, 95%CI=1.688-3.788, P=0.000; CCversusCA+AA, OR=2.572, 95%CI=1.761-3.758, P=0.000) and esophageal adenocarcinoma (EAC) (CC versus AA, OR=1.592, 95%CI=1.139-2.227, P=0.007; CC+CA versus AA,OR=1.247, 95%CI=1.016-1.530, P=0.035; CCversusCA+AA, OR=1.466, 95%CI=1.069-2.011, P=0.018). CONCLUSION This meta-analysis suggested associations of the A1298C polymorphism with increased risk of esophageal cancer in both Asians and Caucasians. In addition, we found that the MTHFR A1298C polymorphism might influence risk ofESCC and EAC in the overall studies.
Exocyst Subunit EXO70H4 Has a Specific Role in Callose Synthase Secretion and Silica Accumulation1[OPEN]

Exocyst subunit EXO70H4 localizes to the apical subdomain of the trichome. Here, it is responsible for callose synthase secretion; callose is essential for cell wall silicification. Biogenesis of the plant secondary cell wall involves many important aspects, such as phenolic compound deposition and often silica encrustation. Previously, we demonstrated the importance of the exocyst subunit EXO70H4 for biogenesis of the trichome secondary cell wall, namely for deposition of the autofluorescent and callose-rich cell wall layer. Here, we reveal that EXO70H4-driven cell wall biogenesis is constitutively active in the mature trichome, but also can be activated elsewhere upon pathogen attack, giving this study a broader significance with an overlap into phytopathology. To address the specificity of EXO70H4 among the EXO70 family, we complemented the exo70H4-1 mutant by 18 different Arabidopsis (Arabidopsis thaliana) EXO70 paralogs subcloned under the EXO70H4 promoter. Only EXO70H4 had the capacity to rescue the exo70H4-1 trichome phenotype. Callose deposition phenotype of exo70H4-1 mutant is caused by impaired secretion of PMR4, a callose synthase responsible for the synthesis of callose in the trichome. PMR4 colocalizes with EXO70H4 on plasma membrane microdomains that do not develop in the exo70H4-1 mutant. Using energy-dispersive x-ray microanalysis, we show that both EXO70H4- and PMR4-dependent callose deposition in the trichome are essential for cell wall silicification.
Forests Regenerating after Clear-Cutting Function as Habitat for Bryophyte and Lichen Species of Conservation Concern

The majority of managed forests in Fennoscandia are younger than 70 years old but yet little is known about their potential to host rare and threatened species. In this study, we examined red-listed bryophytes and lichens in 19 young stands originating from clear-cutting (30–70 years old) in the boreal region, finding 19 red-listed species (six bryophytes and 13 lichens). We used adjoining old stands, which most likely never had been clear-cut, as reference. The old stands contained significantly more species, but when taking the amount of biological legacies (i.e., remaining deciduous trees and dead wood) from the previous forest generation into account, bryophyte species number did not differ between old and young stands, and lichen number was even higher in young stands. No dispersal effect could be detected from the old to the young stands. The amount of wetlands in the surroundings was important for bryophytes, as was the area of old forest for both lichens and bryophytes. A cardinal position of young stands to the north of old stands was beneficial to red-listed bryophytes as well as lichens. We conclude that young forest plantations may function as habitat for red-listed species, but that this depends on presence of structures from the previous forest generation, and also on qualities in the surrounding landscape. Nevertheless, at repeated clear-cuttings, a successive decrease in species populations in young production stands is likely, due to increased fragmentation and reduced substrate amounts. Retention of dead wood and deciduous trees might be efficient conservation measures. Although priority needs to be given to preservation of remnant old-growth forests, we argue that young forests rich in biological legacies and located in landscapes with high amounts of old forests may have a conservation value.
THERMAL FRACTURE PHENOMENA IN BITUMINOUS SURFACES

THIS PAPER EXPLORES THE PHENOMENON OF THERMALLY INDUCED CRACKING IN BITUMINOUS SURFACES AS A PROBLEM PRIMARILY ASSOCIATED WITH DESIGN. LOW-TEMPERATURE EFFECTS ON PAVEMENT PERFORMANCE ARE EXAMINED AND THE NEED FOR MODIFYING CURRENT MIXTURE DESIGN PROCEDURES IS DISCUSSED. SINCE ANY SUCH DESIGN REQUIREMENTS WOULD BE CONCERNED WITH FRACTURE SUSCEPTIBILITY, AN APPROXIMATE PROCEDURE FOR CALCULATING THERMALLY INDUCED STRESSES IS PRESENTED WHICH RECOGNIZES THE PROBABLE STIFFNESS AND TEMPERATURE GRADIENTS THAT OCCUR IN FIELD SERVICE. A CONSIDERATION OF FUNDAMENTAL MECHANISMS INVOLVED IS ESSENTIAL TO ADEQUATELY FULFILLING DESIGN OBJECTIVES, CONSEQUENTLY, AN HYPOTHESIS HAS BEEN ADVANCED TO THE EFFECT THAT THERMALLY INDUCED CRACKING OCCURS IN TWO MAIN PHASES. THESE CONSIST ESSENTIALLY OF LIMITED-DEPTH CRACK INITIATION, AND SUBSEQUENT FULL-DEPTH PROPAGATION WITH RISING AIR TEMPERATURES. THE PERTINENT MECHANICS ARE EXPLAINED AND THE HYPOTHESIS APPEARS TO BE COMPATIBLE WITH OBSERVED PHENOMENA. SEVERAL PRACTICAL IMPLICATIONS OF THE HYPOTHESIS ARE DISCUSSED AND THESE RELATE PRIMARILY TO THE DEVELOPMENT OF MIX DESIGNS TO MITIGATE OF REDUCE CRACKING AND TO THE POSSIBLE USE OF 'GOOD' AND 'POOR' ASPHALTS IN THE SAME PAVEMENT STRUCTURE. IT IS SUGGESTED THAT MORE EFFICIENT AND ECONOMICAL USES OF AVAILABLE MATERIALS MAY BE POSSIBLE IN DESIGNING FOR THE LOW-TEMPERATURE CRACKING PROBLEM. /AUTHOR/
High Lewis Number Combustion Wavefronts: A Perturbative Melnikov Analysis

The wavefronts associated with a one‐dimensional combustion model with Arrhenius kinetics and no heat loss are analyzed within the high Lewis number perturbative limit. This situation, in which fuel diffusivity is small in comparison to that of heat, is appropriate for highly dense fluids. A formula for the wavespeed is established by a nonstandard application of Melnikov’s method and slow manifold theory from dynamical systems, and compared to numerical results. A simple characterization of the wavespeed correction is obtained: it is proportional to the ratio between the exothermicity parameter and the Lewis number. The perturbation method developed herein is also applicable to more general coupled reaction‐diffusion equations with strongly differing diffusivities. The stability of the wavefronts is also tested using a numerical Evans function method.
Knowledge and Awareness of HPV Vaccine and Acceptability to Vaccinate in Sub-Saharan Africa: A Systematic Review

Objectives We assessed the knowledge and awareness of cervical cancer, HPV and HPV vaccine, and willingness and acceptability to vaccinate in sub-Saharan African (SSA) countries. We further identified countries that fulfill the two GAVI Alliance eligibility criteria to support nationwide HPV vaccination. Methods We conducted a systematic review of peer-reviewed studies on the knowledge and awareness of cervical cancer, HPV and HPV vaccine, and willingness and acceptability to vaccinate. Trends in Diphtheria-tetanus-pertussis (DTP3) vaccine coverage in SSA countries from 1990–2011 were extracted from the World Health Organization database. Findings The review revealed high levels of willingness and acceptability of HPV vaccine but low levels of knowledge and awareness of cervical cancer, HPV or HPV vaccine. We identified only six countries to have met the two GAVI Alliance requirements for supporting introduction of HPV vaccine: 1) the ability to deliver multi-dose vaccines for no less than 50% of the target vaccination cohort in an average size district, and 2) achieving over 70% coverage of DTP3 vaccine nationally. From 2008 through 2011 all SSA countries, with the exception of Mauritania and Nigeria, have reached or maintained DTP3 coverage at 70% or above. Conclusion There is an urgent need for more education to inform the public about HPV, HPV vaccine, and cervical cancer, particularly to key demographics, (adolescents, parents and healthcare professionals), to leverage high levels of willingness and acceptability of HPV vaccine towards successful implementation of HPV vaccination programs. There is unpreparedness in most SSA countries to roll out national HPV vaccination as per the GAVI Alliance eligibility criteria for supporting introduction of the vaccine. In countries that have met 70% DTP3 coverage, pilot programs need to be rolled out to identify the best practice and strategies for delivering HPV vaccines to adolescents and also to qualify for GAVI Alliance support.
Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and/or antiphospholipid antibodies

Objective Studies in mouse models implicate complement activation as a causative factor in adverse pregnancy outcomes (APOs). We investigated whether activation of complement early in pregnancy predicts APOs in women with systemic lupus erythematosus (SLE) and/or antiphospholipid (aPL) antibodies. Methods The PROMISSE Study enrolled pregnant women with SLE and/or aPL antibodies (n=487) and pregnant healthy controls (n=204) at <12 weeks gestation and evaluated them monthly. APOs were: fetal/neonatal death, preterm delivery <36 weeks because of placental insufficiency or preeclampsia and/or growth restriction <5th percentile. Complement activation products were measured on serial blood samples obtained at each monthly visit. Results APO occurred in 20.5% of SLE and/or aPL pregnancies. As early as 12–15 weeks, levels of Bb and sC5b-9 were significantly higher in patients with APOs and remained elevated through 31 weeks compared with those with normal outcomes. Moreover, Bb and sC5b-9 were significantly higher in patients with SLE and/or aPL without APOs compared with healthy controls. In logistic regression analyses, Bb and sC5b-9 at 12–15 weeks remained significantly associated with APO (ORadj=1.41 per SD increase; 95% CI 1.06 to 1.89; P=0.019 and ORadj=1.37 per SD increase; 95% CI 1.05 to 1.80; P=0.022, respectively) after controlling for demographic and clinical risk factors for APOs in PROMISSE. When analyses were restricted to patients with aPL (n=161), associations between Bb at 12–15 weeks and APOs became stronger (ORadj=2.01 per SD increase; 95% CI 1.16 to 3.49; P=0.013). Conclusion In pregnant patients with SLE and/or aPL, increased Bb and sC5b-9 detectable early in pregnancy are strongly predictive of APOs and support activation of complement, particularly the alternative pathway, as a contributor to APOs.
Permanent Magnet Synchronous Machine Hybrid Torque Control

This paper presents a control scheme suitable for systems composed of a continuous process modulated in energy by a power converter with a finite number of topologies. To track the continuous reference values, a topology of the power converter is determined from a criterion based on a process state variable model and taking into account the possible topologies of the power converter. The proposed hybrid control scheme is applied to an electrical motor drive composed of an inverter coupled to a permanent magnet synchronous machine. An evolution which insures a fixed modulation frequency is also proposed. Experimental results validate the feasibility and effectiveness of the proposed schemes.
Enhanced Emission Efficiency of Size-Controlled InGaN/GaN Green Nanopillar Light-Emitting Diodes

Nanopillar InGaN/GaN green light-emitting diode (LED) arrays were fabricated by self-assembled Au nanoparticles patterning and dry etching process. Structure size and density of the nanopillar arrays have been modified by varying the Au film thickness in the nanopatterning process. Fabricated nanopillar LEDs have been characterized by both room temperature and temperature-dependent photoluminescence measurements. A considerable internal quantum efficiency enhancement was achieved which is attributed to the suppressed quantum confined Stark effect derived from the internal strain relaxation. Meanwhile light extraction efficiency can also be enhanced significantly due to the increased light scattering at nanopillar sidewall. Compared to the planar LED, the nanopillar LED demonstrates the greatest external quantum efficiency enhancement by a factor of 4.08. It is believed that this nanopillar fabrication method can serve as an effective approach to increase the luminescence efficiency of LEDs.
CONFIRMATION OF A RETROGRADE ORBIT FOR EXOPLANET WASP-17b

We present high-precision radial velocity observations of WASP-17 throughout the transit of its close-in giant planet, using the MIKE spectrograph on the 6.5 m Magellan Telescope at Las Campanas Observatory. By modeling the Rossiter–McLaughlin effect, we find the sky-projected spin–orbit angle to be λ = 167.4 ± 11.2 deg. This independently confirms the previous finding that WASP-17b is on a retrograde orbit, suggesting it underwent migration via a mechanism other than just the gravitational interaction between the planet and the disk. Interestingly, our result for λ differs by 45 ± 13 deg from the previously announced value, and we also find that the spectroscopic transit occurs 15 ± 5 minutes earlier than expected, based on the published ephemeris. The discrepancy in the ephemeris highlights the need for contemporaneous spectroscopic and photometric transit observations whenever possible.
THE SCOPE AND GENERALITY OF AUTOMATIC AFFECTIVE BIASES IN POLITICAL THINKING: REPLY TO THE SYMPOSIUM

Abstract Our response to this symposium on our 2006 paper centers on three questions. First, what motivations exist in the political wild, and do our experimental manipulations realistically capture them? We agree that strong accuracy motivations are likely (but not certain) to reduce biases, but we are not at all confident that the real world supplies stronger accuracy motivations than our subjects received. Second, how can we square our findings of stubbornly persistent beliefs and attitudes with the well-established literatures on framing and persuasion, which find political opinion to be more malleable? We argue that our John Q. Public theory of political information accounts for both persistence and persuasion and explains when we should expect one or the other. Citizens will be more responsive to contextual information or persuasive appeals when prior feelings are weak, knowledge is sparse, and information is encountered outside of awareness. Resistance to information or arguments is most likely when prior feelings are strong, attitudes are embedded within dense knowledge networks, and appeals are consciously perceived. Third, is belief persistence driven by feelings and emotions, as we claim, or is it more the result of a conviction that one's priors are accurate? We suggest that the distinctions that stand behind this question are suspect. We see in some of our commentators a tendency to align accuracy motivation, central processing, and cognition on one side of the dual-processing framework, with directional motivation, peripheral processing, and feelings on the other side. On the contrary, we argue that beliefs in the truth of one's priors often result from feelings and wishes and are themselves sources of motivated bias in processing new information. Moreover, directional motivations are also often a source of central processing, so it is not easy to disentangle these processes.
Antibiotic-induced population fluctuations and stochastic clearance

13 Effective antibiotic use that minimizes treatment failures remains a challenge. A better understanding of 14 how bacterial populations respond to antibiotics is necessary. Previous studies of large bacterial 15 populations established the current deterministic framework of pharmacodynamics. Here, characterizing 16 the dynamics of population extinction, we demonstrated the stochastic nature of eradicating bacteria with 17 antibiotics. Antibiotics known to kill bacteria (bactericidal) induced population fluctuations. Thus, at high 18 antibiotic concentrations, the dynamics of bacterial clearance were heterogeneous . At l w concentrations , 19 clearance still occurred with a non-zero probability . These striking outcomes of population fluctuations 20 were well captured by our probabilistic model . Our model further suggested a strategy to facilitate 21 eradication by increasing extinction probability . We experimentally tested this prediction for antibiotic22
Career Barriers among Information Technology Undergraduate Majors

Structural changes in the economy have created an employment environment that dictates hiring selectivity within the information technology (IT) field. Higher employer expectations combined with a tighter career market have introduced challenging career barriers for IT undergraduate majors. Swanson and Woitke (1997) defined career barriers as “events or conditions, either within the person or in his or her environment, that make career progress difficult” (p. 434). The purpose of this study was to examine the perceived likelihood of encountering certain career barriers and, if the barriers were encountered, the degree to which the barriers would hinder undergraduate IT majors’ career progress. The findings of this study support recent research (Luzzo & McWhirter, 2001) that found women perceived significantly greater career barriers than men did, especially for career choice. Ethnic minorities perceived greater barriers to finding a job, job performance, and career balance than non-minorities.
6 million spam tweets: A large ground truth for timely Twitter spam detection

Twitter has changed the way of communication and getting news for people's daily life in recent years. Meanwhile, due to the popularity of Twitter, it also becomes a main target for spamming activities. In order to stop spammers, Twitter is using Google SafeBrowsing to detect and block spam links. Despite that blacklists can block malicious URLs embedded in tweets, their lagging time hinders the ability to protect users in real-time. Thus, researchers begin to apply different machine learning algorithms to detect Twitter spam. However, there is no comprehensive evaluation on each algorithms' performance for real-time Twitter spam detection due to the lack of large groundtruth. To carry out a thorough evaluation, we collected a large dataset of over 600 million public tweets. We further labelled around 6.5 million spam tweets and extracted 12 light-weight features, which can be used for online detection. In addition, we have conducted a number of experiments on six machine learning algorithms under various conditions to better understand their effectiveness and weakness for timely Twitter spam detection. We will make our labelled dataset for researchers who are interested in validating or extending our work.
Core beliefs in healthy youth and youth at ultra high-risk for psychosis: Dimensionality and links to depression, anxiety, and attenuated psychotic symptoms

Abstract Cognitive theory posits that core beliefs play an active role in developing and maintaining symptoms of depression, anxiety, and psychosis. This study sought to comprehensively examine core beliefs, their dimensionality, and their relationships to depression, anxiety, and attenuated psychotic symptoms in two groups of community youth: a group at ultrahigh risk for psychosis (UHR; n = 73, M age = 18.7) and a matched healthy comparison group (HC; n = 73, M age = 18.1). UHR youth reported significantly more negative beliefs about self and others, and significantly less positive beliefs about self and others. HC youth rarely endorsed negative self-beliefs. Exploratory factor analyses found that HC negative self-beliefs did not cohere as a single factor. We hypothesized specific links between core beliefs and symptoms based on cognitive models of each disorder, and tested these links through regression analyses. The results in the HC group were consistent with the proposed models of depression and anxiety. The results in the UHR group were consistent with proposed models of depression and negative psychotic symptoms, somewhat consistent with a proposed model of positive psychotic symptoms, and not at all consistent with a proposed model of anxiety. These findings add to a growing developmental literature on core beliefs and psychopathology, with important clinical implications.
Model selection and averaging in the assessment of the drivers of household food waste to reduce the probability of false positives

Food waste from households contributes the greatest proportion to total food waste in developed countries. Therefore, food waste reduction requires an understanding of the socio-economic (contextual and behavioural) factors that lead to its generation within the household. Addressing such a complex subject calls for sound methodological approaches that until now have been conditioned by the large number of factors involved in waste generation, by the lack of a recognised definition, and by limited available data. This work contributes to food waste generation literature by using one of the largest available datasets that includes data on the objective amount of avoidable household food waste, along with information on a series of socio-economic factors. In order to address one aspect of the complexity of the problem, machine learning algorithms (random forests and boruta) for variable selection integrated with linear modelling, model selection and averaging are implemented. Model selection addresses model structural uncertainty, which is not routinely considered in assessments of food waste in literature. The main drivers of food waste in the home selected in the most parsimonious models include household size, the presence of fussy eaters, employment status, home ownership status, and the local authority. Results, regardless of which variable set the models are run on, point toward large households as being a key target element for food waste reduction interventions.
Plant Chemistry and Local Adaptation of a Specialized Folivore

Local adaptation is central for creating and maintaining spatial variation in plant-herbivore interactions. Short-lived insect herbivores feeding on long-lived plants are likely to adapt to their local host plants, because of their short generation time, poor dispersal, and geographically varying selection due to variation in plant defences. In a reciprocal feeding trial, we investigated the impact of geographic variation in plant secondary chemistry of a long-lived plant, Vincetoxicum hirundinaria, on among-population variation in local adaptation of a specialist leaf-feeding herbivore, Abrostola asclepiadis. The occurrence and degree of local adaptation varied among populations. This variation correlated with qualitative and quantitative differences in plant chemistry among the plant populations. These findings provide insights into the mechanisms driving variation in local adaptation in this specialized plant-herbivore interaction.