Miracle-dz/UniFAR-FTUs huggingface dataset:
A Decade of Online Advertising Research: What We Learned and What We Need to Know

Since the appearance of the first banner ad, online advertising has evolved significantly and now accounts for a substantial portion of all advertising spending. As online advertising tools proliferate, academic research in this area has also matured over time. To capture these developments, this article offers a synthesis of more than 300 articles on online advertising published in major advertising and marketing journals over the past 10 years. The key literature is summarized around six themes: (1) online advertising effectiveness; (2) online advertising mechanisms; (3) creative elements in online advertising; (4) the role of context in online advertising; (5) online personalization; and (6) search advertising. Knowledge gaps in existing research are identified, and important future research questions are suggested.
Educational Development: Discourse, Identity and Practice

In higher education institutions worldwide, issues relating to quality in teaching and learning have gained prominence over the last two decades as student numbers, and the need to be publicly accountable, have increased. During this time a sizeable community of educational developers has emerged whose work and research focuses on the enhancement of the student experience in higher education. A significant issue for these developers is how change can be effected in organisations with well-established academic cultures and practices, beset by many other priorities and pressures. This first book-length analysis of developers as a community of practice illustrates in their own words the issues they face, their differing orientations to development (given their differing organisational cultures), and how they see their institutional role. What emerges is the contested notion of 'development' itself, and a tribe of developers who, though fragmented, offer a rich variation in their discourse, identity and practice. Drawing upon developers' own voices, the book offers a lively and accessible narrative approach to this rapidly evolving area. It is a useful guide to help individual developers compare their own practice with that of others, and development teams to map the effectiveness of their own centre's provision. Educational Development is essential reading for educational developers, teaching and learning co-ordinators and teaching fellows, as well as senior managers with remits for academic development, and directors of quality assurance. It is also of interest to those in higher education who are concerned with bringing about organisational or cultural change.
Formation of a distinct connexin 43 phosphoisoform in mitotic cells is dependent upon p 34 cdc 2 kinase

The gap junction protein connexin43 is a phosphoprotein that typically migrates as three bands (nonphosphorylated, P1 and P2) during polyacrylamide gel electrophoresis. The electrophoretic mobility of connexin43 from mitotic cells was distinctly reduced to a form (P3) that migrated slower than P2 from Rat1 cells prepared by shakeoff of nocodazole-treated and untreated cultures. Mitotic FT210 cells, which contain a temperature-sensitive mutation in the p34cdc2 kinase, showed abundant levels of the P3 connexin43 when maintained at the permissive temperature where p34cdc2 is active. In contrast, nocodozole-treated FT210 cells grown at the nonpermissive temperature did not contain P3 connexin43. These results indicated that generation of the P3 connexin43 was dependent upon active p34 cdc2/cyclin B kinase. Although the p34cdc2 kinase phosphorylated connexin43 in vitro on peptides containing serine 255, the major phosphotryptic peptides in P3 connexin43 from mitotic cells appeared to be the consequence of another protein kinase(s), which may be activated by the p34cdc2/cyclin B kinase. The P3 connexin43 exhibited a marked redistribution from cell-cell plasma membrane interfaces to multiple, distinctly stained cytoplasmic structures. These events may be part of the dramatic structural changes observed in mitotic cells undergoing cell rounding and cytokinesis. Results of initial studies using inhibitors of protein degradative and synthetic pathways suggested the likelihood that protein degradation and synthesis participate in the disappearance of the P3 connexin43 and restoration of the pattern of connexin43 isoforms observed in nonmitotic cells.
Secondary students' online use and creation of knowledge: Refocusing priorities for quality assessment and learning

In this increasingly convergent and digital world, young people are reportedly using new media with high engagement outside school, yet disengaged in those schools where technology access is low or restricted. Such an apparent disconnection is magnified when predictions of their futures are tied to requisites including technological expertise, adaptability to change, innovative capacities and complex problem-solving abilities. Such future oriented capacities challenge traditional views that basic literate and numerate proficiency is sufficient for academic success. They also raise questions about the sufficiency of digital engagement for developing higher order critical and creative skills. Collectively, these future oriented capacities heighten educational imperatives for improving the quality of young people’s learning outcomes in this rapidly changing online world. This article addresses these issues. It draws on diverse literature sources and an Australian research study (2003‐2008) into secondary students’ curricular digital literacies (Appendix A) to present conceptual advances in understandings about how to recognise, talk about and value signs of quality learning in student-created multimodal products. Finally, the article offers an assessment framework with potential for assisting students and teachers to access core concepts and mobilise those essential capacities for enhancing performance when using and creating knowledge online.
THE SPLASH SURVEY: A SPECTROSCOPIC ANALYSIS OF THE METAL-POOR, LOW-LUMINOSITY M31 dSph SATELLITE ANDROMEDA X,

Andromeda X (And X) is a newly discovered low-luminosity M31 dwarf spheroidal galaxy (dSph) found by Zucker et al. in the Sloan Digital Sky Survey (SDSS; York et al.). In this paper, we present the first spectroscopic study of individual red giant branch stars in And X, as a part of the Spectroscopic and Photometric Landscape of Andromeda's Stellar Halo (SPLASH) Survey. Using the Keck II telescope and multiobject DEIMOS spectrograph, we target two spectroscopic masks over the face of the galaxy and measure radial velocities for ∼100 stars with a median accuracy of σv ∼ 3 km s−1. The velocity histogram for this field confirms three populations of stars along the sight line: foreground Milky Way dwarfs at small negative velocities, M31 halo red giants over a broad range of velocities, and a very cold velocity “spike” consisting of 22 stars belonging to And X with vrad = −163.8 ± 1.2 km s−1. By carefully considering both the random and systematic velocity errors of these stars (e.g., through duplicate star measurements), we derive an intrinsic velocity dispersion of just σv = 3.9 ± 1.2 km s−1 for And X, which for its size, implies a minimum mass-to-light ratio of M/LV = 37+26−19 assuming that the mass traces the light. Based on the clean sample of member stars, we measure the median metallicity of And X to be [Fe/H] = −1.93 ± 0.11, with a slight radial metallicity gradient. The dispersion in metallicity is large, σ([Fe/H]phot) = 0.48, possibly hinting that the galaxy retained much of its chemical enrichment products. And X has a total integrated luminosity (MV = −8.1 ± 0.5) that straddles the classical Local Group dSphs and the new SDSS ultra-low luminosity galaxies. The galaxy is among the most metal-poor dSphs known, especially relative to those with MV < −8, and has the second lowest intrinsic velocity dispersion of the entire sample. Our results suggest that And X is less massive by a factor of 4 when compared to Milky Way dSphs of comparable luminosity (e.g., Draco and Ursa Minor). We discuss the potential for better understanding the formation and evolution mechanisms for M31's system of dSphs through (current) kinematic and chemical abundance studies, especially in relation to the Milky Way sample.
Fixing the Growth Illusion: New Directions for Research in Resilience and Posttraumatic Growth

The literature on resilience and posttraumatic growth has been instrumental in highlighting the human capacity to overcome adversity by illuminating that there are different pathways individuals may follow. Although the theme of strength from adversity is attractive and central to many disciplines and certain cultural narratives, this claim lacks robust empirical evidence. Specific issues include methodological approaches of using growth-mixture modeling in resilience research and retrospective assessments of growth. Conceptually, limitations exist in the examination of which outcomes are most appropriate for studying resilience and growth. We discuss new research intended to overcome these limitations, with a focus on prospective longitudinal designs and the value of integrating these disciplines for furthering our understanding of the human capacity to overcome adversity.
Lack of genetic isolation by distance, similar genetic structuring but different demographic histories in a fig‐pollinating wasp mutualism

Historical abiotic factors such as climatic oscillations and extreme climatic events as well as biotic factors have shaped the structuring of species' genetic diversity. In obligate species‐specific mutualisms, the biogeographic histories of the interacting species are tightly linked. This could be particularly true for nuclear genes in the Ficus‐pollinating wasp mutualistic association as the insects disperse pollen from their natal tree. In this study, we compare spatial genetic structure of plant and pollinator for the Ficus hirta–Valisia javana association throughout southeast China including Hainan Island, for both nuclear and cytoplasmic markers. We show that dispersal of the insect leads to plant and insect presenting similar signatures of lack of genetic isolation by distance for nuclear genes on the continent over a distance of 1000 km. But we also show that the demographic histories of plant and insect are strikingly different. This is in agreement with extreme climatic events leading to transient regional extinctions of the insects, associated with local survival of the plants. We also observe evidence of genetic differentiation for both wasps and fig‐tree between the continent and Hainan Island, although the Qiongzhou Strait is only on average 30 km wide, suggesting that geographic isolation by itself has not been sufficient to generate this differentiation. Hence, our results suggest that in highly dispersive mutualistic systems, isolation‐by‐dispersal limitation across a geographic barrier could be supplemented by isolation by adaptation, and maybe by coevolution, allowing further genetic divergence. In such systems, species may frequently be composed of a single population.
The ACS Virgo Cluster Survey. II. Data Reduction Procedures

The ACS Virgo Cluster Survey is a large program to carry out multicolor imaging of 100 early-type members of the Virgo Cluster using the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope. Deep F475W and F850LP images (≈SDSS g and z) are being used to study the central regions of the program galaxies, their globular cluster systems, and the three-dimensional structure of Virgo itself. In this paper, we describe in detail the data reduction procedures used for the survey, including image registration, drizzling strategies, the computation of weight images, object detection, the identification of globular cluster candidates, and the measurement of their photometric and structural parameters.
How do Regulatory T Cells Work?

CD4+ T cells are commonly divided into regulatory T (Treg) cells and conventional T helper (Th) cells. Th cells control adaptive immunity against pathogens and cancer by activating other effector immune cells. Treg cells are defined as CD4+ T cells in charge of suppressing potentially deleterious activities of Th cells. This review briefly summarizes the current knowledge in the Treg field and defines some key questions that remain to be answered. Suggested functions for Treg cells include: prevention of autoimmune diseases by maintaining self‐tolerance; suppression of allergy, asthma and pathogen‐induced immunopathology; feto‐maternal tolerance; and oral tolerance. Identification of Treg cells remains problematic, because accumulating evidence suggests that all the presently‐used Treg markers (CD25, CTLA‐4, GITR, LAG‐3, CD127 and Foxp3) represent general T‐cell activation markers, rather than being truly Treg‐specific. Treg‐cell activation is antigen‐specific, which implies that suppressive activities of Treg cells are antigen‐dependent. It has been proposed that Treg cells would be self‐reactive, but extensive TCR repertoire analysis suggests that self‐reactivity may be the exception rather than the rule. The classification of Treg cells as a separate lineage remains controversial because the ability to suppress is not an exclusive Treg property. Suppressive activities attributed to Treg cells may in reality, at least in some experimental settings, be exerted by conventional Th cell subsets, such as Th1, Th2, Th17 and T follicular (Tfh) cells. Recent reports have also demonstrated that Foxp3+ Treg cells may differentiate in vivo into conventional effector Th cells, with or without concomitant downregulation of Foxp3.
redicting maize yield in Zimbabwe using dry dekads derived from emotely sensed Vegetation Condition Index

Maize is a key crop contributing to food security in Southern Africa yet accurate estimates of maize yield prior to harvesting are scarce. Timely and accurate estimates of maize production are essential for ensuring food security by enabling actionable mitigation strategies and policies for prevention of food shortages. In this study, we regressed the number of dry dekads derived from VCI against official ground-based maize yield estimates to generate simple linear regression models for predicting maize yield throughout Zimbabwe over four seasons (2009–10, 2010–11, 2011–12, and 2012–13). The VCI was computed using Normalized Difference Vegetation Index (NDVI) time series dataset from the SPOT VEGETATION sensor for the period 1998–2013. A significant negative linear relationship between number of dry dekads and maize yield was observed in each season. The variation in yield explained by the models ranged from 75% to 90%. The models were evaluated with official ground-based yield data that was not used to generate the models. There is a close match between the predicted yield and the official yield statistics with an error of 33%. The observed consistency in the negative relationship between number of dry dekads and ground-based estimates of maize yield as well as the high explanatory power of the regression models suggest that VCI-derived dry dekads could be used to predict maize yield before the end of the season thereby making it possible to plan strategies for dealing with food deficits or surpluses
How Words Capture Visual Experience: the Perspective from Cognitive Neuroscience

Would it be better to sit in silence? To think everything, to feel everything, to say nothing? This is the way of the orange gourd. This is the habit of the rock in the river, over which the water pours all night and all day. But the nature of man is not the nature of silence. Words are the thunders of the mind. Words are the refinements of the flesh. Words are the responses to the thousand curvaceous moments—we just manage it—sweet and electric, words flow from the brain and out the gate of the mouth. We make books of them, out of hesitations and grammar. We are slow, and choosy. This is the world.
Perceptual Learning vs . Context-Sensitive Retrieval : Why do people judge green lines to be shorter / longer than red lines of the same length ?

The mechanisms of perceptual learning and contextually sensitive retrieval were recently suggested as possible explanations of the effect of irrelevant information on judgment: the judgment of the same stimulus was reported to depend on its irrelevant characteristics. The reported experiments test the chances for a perceptual learning explanation of the effect. Experiment 1 successfully induces the effect of irrelevant dimension in judgment of line lengths, while Experiment 2, performed immediately after the first experiment, tests the possibility that the perceptual learning mechanisms have led to a “rerepresentation” of the line length depending on its color and thus the participants will actually see the red lines as shorter/longer then the red ones. Since Experiment 2 failed to demonstrate any significant difference in perception of the stimulus length depending on its color, the possibility that perceptual learning mechanisms underlie the effect of irrelevant dimension was not empirically supported for the moment.
HIV Viremia and T-Cell Activation Differentially Affect the Performance of Glomerular Filtration Rate Equations Based on Creatinine and Cystatin C

Background Serum creatinine and cystatin C are used as markers of glomerular filtration rate (GFR). The performance of these GFR markers relative to exogenously measured GFR (mGFR) in HIV-positive individuals is not well established. Methods We assessed the performance of the chronic kidney disease epidemiology collaboration equations based on serum concentrations of creatinine (eGFRcr), cystatin C (eGFRcys) and both biomarkers combined (eGFRcr-cys) in 187 HIV-positive and 98 HIV-negative participants. Measured GFR was calculated by plasma iohexol clearance. Bias and accuracy were defined as the difference between eGFR and mGFR and the percentage of eGFR observations within 30% of mGFR, respectively. Activated CD4 and CD8 T-cells (CD38+ HLA-DR+) were measured by flow cytometry. Results The median mGFR was >100 ml/min/1.73 m2 in both groups. All equations tended to be less accurate in HIV-positive than in HIV-negative subjects, with eGFRcr-cys being the most accurate overall. In the HIV-positive group, eGFRcys was significantly less accurate and more biased than eGFRcr and eGFRcr_cys. Additionally eGFRcys bias and accuracy were strongly associated with use of antiretroviral therapy, HIV RNA suppression, and percentages of activated CD4 or CD8 T-cells. Hepatitis C seropositivity was associated with larger eGFRcys bias in both HIV-positive and HIV-negative groups. In contrast, eGFRcr accuracy and bias were not associated with HIV-related factors, T-cell activation, or hepatitis C. Conclusions The performance of eGFRcys relative to mGFR was strongly correlated with HIV treatment factors and markers of T-cell activation, which may limit its usefulness as a GFR marker in this population.
Competitive caching of contents in 5G edge cloud networks

The surge of mobile data traffic forces network operators to cope with capacity shortage. The deployment of small cells in 5G networks shall increase radio access capacity. Mobile edge computing technologies can be used to manage dedicated cache memory at the edge of mobile networks. As a result, data traffic can be confined within the radio access network thus reducing latency, round-trip time and backhaul congestion. Such technique can be used to offer content providers premium connectivity services to enhance the quality of experience of their customers on the move. In this context, cache memory in the mobile edge network becomes a shared resource. We study a competitive caching scheme where contents are stored at a given price set by the mobile network operator. We first formulate a resource allocation problem for a tagged content provider seeking to minimize the expected missed cache rate. The optimal caching policy is derived accounting for popularity of contents, spatial distribution of small cells, and caching strategies of competing content providers. Next, we study a game among content providers in the form of a generalized non-smooth Kelly mechanism with bounded strategy sets and heterogeneous players. Existence and uniqueness of the Nash equilibrium are proved. Finally, numerical results validate and characterize the performance of the system.
Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABAA Receptors

Whereas both GABAA receptors (GABAARs) and glycine receptors (GlyRs) play a role in control of dorsal horn neuron excitability, their relative contribution to inhibition of small diameter primary afferent terminals remains controversial. To address this, we designed an approach for quantitative analyses of the distribution of GABAAR-subunits, GlyR α1-subunit and their anchoring protein, gephyrin, on terminals of rat spinal sensory afferents identified by Calcitonin-Gene-Related-Peptide (CGRP) for peptidergic terminals, and by Isolectin-B4 (IB4) for nonpeptidergic terminals. The approach was designed for light microscopy, which is compatible with the mild fixation conditions necessary for immunodetection of several of these antigens. An algorithm was designed to recognize structures with dimensions similar to those of the microscope resolution. To avoid detecting false colocalization, the latter was considered significant only if the degree of pixel overlap exceeded that expected from randomly overlapping pixels given a hypergeometric distribution. We found that both CGRP+ and IB4+ terminals were devoid of GlyR α1-subunit and gephyrin. The α1 GABAAR was also absent from these terminals. In contrast, the GABAAR α2/α3/α5 and β3 subunits were significantly expressed in both terminal types, as were other GABAAR-associated-proteins (α-Dystroglycan/Neuroligin-2/Collybistin-2). Ultrastructural immunocytochemistry confirmed the presence of GABAAR β3 subunits in small afferent terminals. Real-time quantitative PCR (qRT-PCR) confirmed the results of light microscopy immunochemical analysis. These results indicate that dorsal horn inhibitory synapses follow different rules of organization at presynaptic versus postsynaptic sites (nociceptive afferent terminals vs inhibitory synapses on dorsal horn neurons). The absence of gephyrin clusters from primary afferent terminals suggests a more diffuse mode of GABAA-mediated transmission at presynaptic than at postsynaptic sites.
Implicit Instruction, Subtitles, Vocabulary and Listening Comprehension

This current study is focusing on the impact of English movies with English subtitles and Bahasa Indonesia subtitles on content comprehension of English movies through the students’ listening comprehension. Fifty-six (56) students of English subject at the Politeknik Elektronika Negeri Surabaya were selected randomly. Using the quasi-experimental study, a movie entitled Transcendence was selected based on the ESP content and language level difficulty. With two intact groups, they were group A and group B presented the same movie, class A watched it with English subtitle and class B with Bahasa Indonesia subtitle. After watching the movie, the participants answered the relevant multiple-choice vocabulary by listening session questions and content comprehension questions, they answer the questions on the paper. The data gathered were subjected to the statistical procedure of paired sample t-test. The results showed that English subtitle has an impact better than Bahasa Indonesia subtitle. However, this statistical data failed to show that they get greater development on their vocabulary comprehension. Those findings showed that the students’ listening comprehension does not have any impact on their vocabulary comprehension.