Miracle-dz/UniFAR-FTUs huggingface dataset:
Measurement invariance of the Behavioural Regulation in Sport Questionnaire when completed by young athletes across five European countries

The purpose of this study was (1) to examine the factorial validity of the Behavioural Regulation Sport in Questionnaire (BRSQ) when completed by young soccer players in the Promoting Adolescent Physical Activity (PAPA) project (9-15 years old) in 5 European countries (France: n = 1248, Greece: n = 1507, Norway: n = 1397, Spain: n = 2245, and England: n = 1372) and (2) test the measurement invariance of its latent factors across these 5 countries. First, we tested the exploratory structural equation model (ESEM) factor analyses, allowing cross-loadings between factors, against the traditional independent clusters confirmatory factor analysis model (ICM-CFA), with all cross-loadings constrained to zero. The ESEM showed very Good Fit Indices, whereas the ICM-CFA was not tenable across countries. Second, the ESEM was used as the baseline model for the tests of factor loading (metric) invariance and factor loading plus thresholds (scalar) invariance. The five factors obtained from the analysis were scalar invariant and interpretable across the five countries (languages) as intrinsic motivation, identified, introjected and external regulations, and amotivation, in line with the tenets of self-determination theory). This study contributes to methodological advances in sport psychology, as it is the first time an adaptation of the BRSQ for young participants has been factor analysed comparing the more flexible ESEM to the usual ICM-CFA. Our data clearly favour using the more flexible weak dimensionality model (ESEM) and suggest a fresh interpretation of previous results may be required.
Situated Game Level Editing in Augmented Reality

Level editors let end-users create custom levels and content within a given video game. In this paper, we explore the concept and design of Augmented reality game level editors. These new types of editors are not only spatial and embodied, but also situated, as they enable users to tailor games to the unique characteristics and emotional value of their own space. We present the design and implementation of a prototype level editor that runs on the Microsoft HoloLens. The editor enables users to add virtual content in their homes and add interactions through spatial trigger-action game-logic programming. We had pairs of students create games with the prototype and play each other's games. They reported that games are fun to make, play, and watch others play. Based on the design and evaluation, we propose guidelines for Augmented reality game-authoring tools for end users.
Medication labeling practices at in-patient hospital pharmacies: the present dilemma in Pakistan

Drug labels provide first hand information to the patients as well as it provides a unique identity to the medical product Misreading the label inadequate information on label inappropriate labeling font writing style and its placement on the dosage form are the few of the barriers identified for inappropriate labeling practices Objective The main objective of the present study was to assess current labeling practices in inpatient departments of health care facilities among public and private sectors in twin cities of Pakistan Methodology A descriptive cross sectional study design was used A total of twenty healthcare facilities were randomly selected i e from public and from private sectors As per WHO criteria thirty encounters per facility were observed ISMP guidelines were used to develop a structured observation form After data collection data was recorded on structured observation form containing pre determined set of indicators After data collection data was cleaned coded and entered in SPSS version Descriptive statistics of frequency and percentages were calculated Kruskal Wallis and Mann Whitney tests p le were performed to find out differences among variables Results Out of total hospitals visited only were having proper IPD pharmacy setup in public sector while in private sector were having proper IPD pharmacy setup Significant differences p le were found among the labeling practices carried for label identification label instruction and label layout with respect to city sector gender designation age experience and dosage form Labeling practices carried in private sector and healthcare facilities located in Islamabad were comparatively better than the public sector and healthcare facilities located in Rawalpindi Pharmacists had relatively more compliance with the standard labeling guidelines Conclusion The present study concluded that the labeling practices carried at the hospital pharmacies were not up to the mark Although labeling practices in terms of labeling identification was appropriately mentioned but labeling instructions and layout were not in compliance with the standard labeling guidelines This might be due to lack of availability implementation of national standard labeling guidelines lack of interest knowledge and training of dispensers regarding good labeling practices nbsp
Analysis of 3-D Tongue Motion From Tagged and Cine Magnetic Resonance Images.

PURPOSE Measuring tongue deformation and internal muscle motion during speech has been a challenging task because the tongue deforms in 3 dimensions, contains interdigitated muscles, and is largely hidden within the vocal tract. In this article, a new method is proposed to analyze tagged and cine magnetic resonance images of the tongue during speech in order to estimate 3-dimensional tissue displacement and deformation over time. METHOD The method involves computing 2-dimensional motion components using a standard tag-processing method called harmonic phase, constructing superresolution tongue volumes using cine magnetic resonance images, segmenting the tongue region using a random-walker algorithm, and estimating 3-dimensional tongue motion using an incompressible deformation estimation algorithm. RESULTS Evaluation of the method is presented with a control group and a group of people who had received a glossectomy carrying out a speech task. A 2-step principal-components analysis is then used to reveal the unique motion patterns of the subjects. Azimuth motion angles and motion on the mirrored hemi-tongues are analyzed. CONCLUSION Tests of the method with a various collection of subjects show its capability of capturing patient motion patterns and indicate its potential value in future speech studies.
Secure Attribute-Based Signature Scheme With Multiple Authorities for Blockchain in Electronic Health Records Systems

Electronic Health Records (EHRs) are entirely controlled by hospitals instead of patients, which complicates seeking medical advices from different hospitals. Patients face a critical need to focus on the details of their own healthcare and restore management of their own medical data. The rapid development of blockchain technology promotes population healthcare, including medical records as well as patient-related data. This technology provides patients with comprehensive, immutable records, and access to EHRs free from service providers and treatment websites. In this paper, to guarantee the validity of EHRs encapsulated in blockchain, we present an attribute-based signature scheme with multiple authorities, in which a patient endorses a message according to the attribute while disclosing no information other than the evidence that he has attested to it. Furthermore, there are multiple authorities without a trusted single or central one to generate and distribute public/private keys of the patient, which avoids the escrow problem and conforms to the mode of distributed data storage in the blockchain. By sharing the secret pseudorandom function seeds among authorities, this protocol resists collusion attack out of $N$ from $N-1$ corrupted authorities. Under the assumption of the computational bilinear Diffie-Hellman, we also formally demonstrate that, in terms of the unforgeability and perfect privacy of the attribute-signer, this attribute-based signature scheme is secure in the random oracle model. The comparison shows the efficiency and properties between the proposed method and methods proposed in other studies.
Rates of Microbiologically Diagnosed Infection and Pathogen Detection in Hematopoietic Stem Cell Transplant Patients

ABSTRACT Infections remain a significant cause of mortality in hematopoietic stem cell transplant patients. Evaluations of causes of infection are often unrevealing, and at some sites, increasing rates of antimicrobial resistance have been noticed. We performed a retrospective analysis of infection rates and microbiologic testing yield, or percent of tests ordered to diagnose an infection, in the first 100 days of 30 allogeneic and 56 autologous stem cell transplants performed at San Antonio Military Medical Center from July 2011 to April 2014. Blood stream infections were diagnosed in 11.6% with a yield of 6%. Urinary tract infections were diagnosed in 2.3% with a yield of 3%. Clostridium difficile infections were diagnosed in 9.3% and testing yield was 6%. Incidence of respiratory viruses was 5.8% with 4 rhinoviruses/enteroviruses and 1 influenza virus identified. One Proteus mirabilis urinary isolate was an extended spectrum beta-lactamase producer. Five patients, 13% of allogeneic and 4% of autologous patients, died within the first 100 days post-transplantation. History of bacteremia was present in 60% of patients who died; however, only one died due to a microbiologically diagnosed infection. Improved diagnostic tests and methods are needed to increase yield of detection of infection in hematopoietic stem cell transplant patients.
Responses to High Seawater Temperatures in Zooxanthellate Octocorals

Increases in Sea Surface Temperatures (SSTs) as a result of global warming have caused reef-building scleractinian corals to bleach worldwide, a result of the loss of obligate endosymbiotic zooxanthellae. Since the 1980’s, bleaching severity and frequency has increased, in some cases causing mass mortality of corals. Earlier experiments have demonstrated that zooxanthellae in scleractinian corals from three families from the Great Barrier Reef, Australia (Faviidae, Poritidae, and Acroporidae) are more sensitive to heat stress than their hosts, exhibiting differential symptoms of programmed cell death – apoptosis and necrosis. Most zooxanthellar phylotypes are dying during expulsion upon release from the host. The host corals appear to be adapted or exapted to the heat increases. We attempt to determine whether this adaptation/exaptation occurs in octocorals by examining the heat-sensitivities of zooxanthellae and their host octocoral alcyonacean soft corals – Sarcophyton ehrenbergi (Alcyoniidae), Sinularia lochmodes (Alcyoniidae), and Xenia elongata (Xeniidae), species from two different families. The soft coral holobionts were subjected to experimental seawater temperatures of 28, 30, 32, 34, and 36°C for 48 hrs. Host and zooxanthellar cells were examined for viability, apoptosis, and necrosis (in hospite and expelled) using transmission electron microscopy (TEM), fluorescent microscopy (FM), and flow cytometry (FC). As experimental temperatures increased, zooxanthellae generally exhibited apoptotic and necrotic symptoms at lower temperatures than host cells and were expelled. Responses varied species-specifically. Soft coral hosts were adapted/exapted to higher seawater temperatures than their zooxanthellae. As with the scleractinians, the zooxanthellae appear to be the limiting factor for survival of the holobiont in the groups tested, in this region. These limits have now been shown to operate in six species within five families and two orders of the Cnidaria in the western Pacific. We hypothesize that this relationship may have taxonomic implications for other obligate zooxanthellate cnidarians subject to bleaching.
Reducing the sexual risk behaviors of HIV+ individuals: Outcome of a randomized controlled trial

Testing behavioral interventions to increase safer sex practices of HIV+ individuals has the potential to significantly reduce the number of new infections. This study evaluated a behavioral intervention designed to reduce the sexual risk behaviors of HIV+ individuals. HIV+ individuals (N = 387) who reported engaging in unprotected sex with HIV- or partners of unknown serostatus were randomly assigned to (a) a single counseling session targeting problem areas identified by the participant in 3 possible intervention domains (i.e., condom use, negotiation, disclosure); (b) a single-session comprehensive intervention that covered all 3 intervention domains; (c) the same comprehensive intervention, plus 2 monthly booster sessions; or (d) a 3-session diet and exercise attention-control condition. The median number of unprotectedsex acts decreasedfrom 14 at baseline to6, 6, and4 at 4-, 8-, and 12-month follow-ups, respectively. A repeated measures analysis of variance revealed a significant decrease in unprotected sex acts across all groups across time. A significant Group x Time interaction revealed that the comprehensive-with-boosters group had the most unprotected sex at 8-month follow-up as compared to the other 3 groups. These findings suggest that a brief intervention can result in large reductions in HIV transmission risks among HIV+ individuals, but the relative benefit of one intervention approach over another remains unclear.
Methanogenic Paraffin Biodegradation: Alkylsuccinate Synthase Gene Quantification and Dicarboxylic Acid Production

ABSTRACT Paraffinic n-alkanes (>C17) that are solid at ambient temperature comprise a large fraction of many crude oils. The comparatively low water solubility and reactivity of these long-chain alkanes can lead to their persistence in the environment following fuel spills and pose serious problems for crude oil recovery operations by clogging oil production wells. However, the degradation of waxy paraffins under the anoxic conditions characterizing contaminated groundwater environments and deep subsurface energy reservoirs is poorly understood. Here, we assessed the ability of a methanogenic culture enriched from freshwater fuel-contaminated aquifer sediments to biodegrade the model paraffin n-octacosane (C28H58). Compared with that in controls, the consumption of n-octacosane was coupled to methane production, demonstrating its biodegradation under these conditions. Smithella was postulated to be an important C28H58 degrader in the culture on the basis of its high relative abundance as determined by 16S rRNA gene sequencing. An identified assA gene (known to encode the α subunit of alkylsuccinate synthase) aligned most closely with those from other Smithella organisms. Quantitative PCR (qPCR) and reverse transcription qPCR assays for assA demonstrated significant increases in the abundance and expression of this gene in C28H58-degrading cultures compared with that in controls, suggesting n-octacosane activation by fumarate addition. A metabolite analysis revealed the presence of several long-chain α,ω-dicarboxylic acids only in the C28H58-degrading cultures, a novel observation providing clues as to how methanogenic consortia access waxy hydrocarbons. The results of this study broaden our understanding of how waxy paraffins can be biodegraded in anoxic environments with an application toward bioremediation and improved oil recovery. IMPORTANCE Understanding the methanogenic biodegradation of different classes of hydrocarbons has important applications for effective fuel-contaminated site remediation and for improved recovery from oil reservoirs. Previous studies have clearly demonstrated that short-chain alkanes (C17) that comprise many fuel mixtures. Using an enrichment culture derived from a freshwater fuel-contaminated site, we demonstrate that the model waxy alkane n-octacosane can be biodegraded under methanogenic conditions by a presumed Smithella phylotype. Compared with that of controls, we show an increased abundance and expression of the assA gene, which is known to be important for anaerobic n-alkane metabolism. Metabolite analyses revealed the presence of a range of α,ω-dicarboxylic acids found only in n-octacosane-degrading cultures, a novel finding that lends insight as to how anaerobic communities may access waxes as growth substrates in anoxic environments.
Pediatric Exposures to Topical Benzocaine Preparations Reported to a Statewide Poison Control System

Introduction Topical benzocaine is a local anesthetic commonly used to relieve pain caused by teething, periodontal irritation, burns, wounds, and insect bites. Oral preparations may contain benzocaine concentrations ranging from 7.5% to 20%. Pediatric exposure to such large concentrations may result in methemoglobinemia and secondarily cause anemia, cyanosis, and hypoxia. Methods This is a retrospective study of exposures reported to a statewide poison control system. The electronic health records were queried for pediatric exposures to topical benzocaine treated at a healthcare facility from 2004 to 2014. Cases of benzocaine exposure were reviewed for demographic and clinical information, and descriptive statistical analysis was performed. Results The query resulted in 157 cases; 58 were excluded due to co-ingestants, or miscoding of non-benzocaine exposures. Children four years of age and younger represented the majority of cases (93%) with a median age of 1 year. There were 88 cases of accidental/ exploratory exposure, while 6 cases resulted from therapeutic application or error, 4 cases from adverse reactions, and 1 case from an unknown cause. Asymptomatic children accounted for 75.5% of cases, but major clinical effects were observed in 5 patients. Those with serious effects were exposed to a range of benzocaine concentrations (7.5–20%), with 4 cases reporting methemoglobin levels between 20.2%–55%. Methylene blue was administered in 4 of the cases exhibiting major effects. Conclusion The majority of exposures were accidental ingestions by young children. Most exposures resulted in minor to no effects. However, some patients required treatment with methylene blue and admission to a critical care unit. Therapeutic application by parents or caregivers may lead to adverse effects from these commonly available products.
Priming Risky Choice: Do Risk Preferences Need Inferences?

The notion that subtle influences, often falling outside awareness, can bias behaviour has a strong grip on both theoretical perspectives and the public imagination. We report three experiments that examined this idea in the context of risky choice. Experiment 1 (N = 100) appeared to find evidence for an interaction whereby participants primed but not reminded of the prime showed an assimilation effect (e.g. participants primed to be risk seeking became more risk seeking) whereas those who were primed and reminded showed a contrast effect (e.g. became less risk seeking). However, two further experiments (N = 180, N = 128) failed to find any evidence for this interaction, and none of the experiments found evidence for the asymmetry in awareness predicted by an ‘unconscious’ assimilation but ‘conscious’ contrast account. The data were analysed using both Null Hypothesis Significance Testing and Bayesian methods, and the implications of the conclusions arising from each are discussed. Whatever one's statistical predilection, the results imply a reduction of confidence in the belief that risk preferences need no inferences. Copyright © 2016 John Wiley & Sons, Ltd.
Broadening the phenotypic spectrum of POP1‐skeletal dysplasias: identification of POP1 mutations in a mild and severe skeletal dysplasia

Processing of Precursor 1 (POP1) is a large protein common to the ribonuclease‐mitochondrial RNA processing (RNase‐MRP) and RNase‐P (RMRP) endoribonucleoprotein complexes. Although its precise function is unknown, it appears to participate in the assembly or stability of both complexes. Numerous RMRP mutations have been reported in individuals with cartilage‐hair hypoplasia (CHH) but, to date, only three POP1 mutations have been described in two families with features similar to anauxetic dysplasia (AD). We present two further individuals, one with severe short stature and a relatively mild skeletal dysplasia and another in whom AD was suspected. Biallelic POP1 mutations were identified in both. A missense mutation and a novel single base deletion were detected in proband 1, p.[Pro582Ser]:[Glu870fs*5]. Markedly reduced abundance of RMRP and elevated levels of pre5.8s rRNA was observed. In proband 2, a homozygous novel POP1 mutation was identified, p.[(Asp511Tyr)];[(Asp511Tyr)]. These two individuals show the phenotypic extremes in the clinical presentation of POP1‐dysplasias. Although CHH and other skeletal dysplasias caused by mutations in RMRP or POP1 are commonly cited as ribosomal biogenesis disorders, recent studies question this assumption. We discuss the past and present knowledge about the function of the RMRP complex in skeletal development.
Modelling the stress–transfer efficiency of carbon–epoxy interfaces

This study involved the investigation of the micromechanics of reinforcement of model carbon fibre–epoxy composites using the technique of remote laser Raman microscopy. The technique allows in situ axial stress monitoring in highly crystalline fibres, such as carbon or Kevlar®. Model composites were subjected to incremental tensile loading, while the stress in the fibre was monitored at each level of applied strain. The stress–transfer regime was studied in the elastic domain using a model single–fibre composite, where a fibre of finite length (i.e. of a length smaller than the coupon gauge length) was embedded along a resin coupon. A shear lag approach was employed to model the stress–transfer efficiency of the interface through the use of the shear–lag parameter β. The stress build–up in the fibre in the presence of energy dissipation mechanisms such as fibre fractures was modelled, and the stress–transfer efficiency was quantified at different levels of applied composite strain. Parallels between the interfacial efficiency of single–fibre systems and practical composites are drawn.
Tools for Predicting the Reliability of Large-Scale Storage Systems

Data-intensive applications require extreme scaling of their underlying storage systems. Such scaling, together with the fact that storage systems must be implemented in actual data centers, increases the risk of data loss from failures of underlying components. Accurate engineering requires quantitatively predicting reliability, but this remains challenging due to the need to account for extreme scale, redundancy scheme type and strength, distribution architecture, and component dependencies. This article introduces CQSim-R, a tool suite for predicting the reliability of large-scale storage system designs and deployments. CQSim-R includes (a) direct calculations based on an only-drives-fail failure model and (b) an event-based simulator for detailed prediction that handles failures of and failure dependencies among arbitrary (drive or nondrive) components. These are based on a common combinatorial framework for modeling placement strategies. The article demonstrates CQSim-R using models of common storage systems, including replicated and erasure coded designs. New results, such as the poor reliability scaling of spread-placed systems and a quantification of the impact of data center distribution and rack-awareness on reliability, demonstrate the usefulness and generality of the tools. Analysis and empirical studies show the tools’ soundness, performance, and scalability.