Miracle-dz/UniFAR-FTUs huggingface dataset:
Single-Stage Revision for Periprosthetic Hip Infection Using Antibiotic Loaded Impaction Graft

Background Staged revision for periprosthetic infection of the hip is an accepted and widely used technique by many surgeons. However, single-stage exchange of the hip prosthesis remains an attractive option to others because of the advantages of reduced morbidity, shorter treatment time and hospital stay in addition to the reduced cost of treatment. Hypothesis Single-stage revision for periprosthetic hip infection can achieve excellent results if a specific protocol for patients’ selection and management is followed. Methods 52 patients with evidence of periprosthetic infection had preoperative aspiration of the affected hip. The infecting organisms were identified in 33/52 and single-stage revision was performed. The remaining 19 patients had a 2-stage exchange arthroplasty. Patients in the single-stage revision protocol had antibiotic loaded morsellized bone graft, a cemented cup and a long cementless stem. Results At an average follow up of 6 (range 4-8) years postoperatively, only 1 case of persistent infection was found in the single-stage group – a 97% rate of eradicating infection was achieved. Discussion Single-stage exchange achieves excellent success rate in patients with periprosthetic infection when a specific protocol for patient selection and management is followed.
FoxP3+RORγt+ T Helper Intermediates Display Suppressive Function against Autoimmune Diabetes

Recently, traces of double-positive FoxP3+RORγt+ T cells were identified and viewed as dual programming differentiation intermediates geared toward development into T regulatory or Th17 cells. In this study, we report that FoxP3+RORγt+ intermediates arise in the NOD mouse T cell repertoire prior to inflammation and can be expanded with tolerogen without further differentiation. Furthermore, FoxP3+RORγt+ cells express both CD62L and membrane-bound TGFβ and use the former to traffic to the pancreas and the latter to suppress effector T cells both in vitro and in vivo. The cells perform these functions as FoxP3+RORγt+ intermediates, despite being able to terminally differentiate into either FoxP3+RORγt− T regulatory or FoxP3−RORγt+ Th17 cells on polarization. These previously unrecognized observations extend plasticity to both differentiation and function and indicate that the intermediates are poised to traffic to sites of inflammation and target diverse pathogenic T cells, likely without prior conditioning by effector T cells, thus broadening efficacy against autoimmunity.
Voronoi State Management for Peer-to-Peer Massively Multiplayer Online Games

State management is a basic requirement for multiuser virtual environments (VEs) such as massively multiplayer online games (MMOGs). Current MMOGs rely on centralized server-clusters that possess inherent scalability bottlenecks and are expensive to adopt and deploy. In this paper, we propose Voronoi state management (VSM) to maintain object states for peer-to-peer-based virtual worlds. By dynamically partitioning the VE with Voronoi diagrams and aggregating game states of overloaded nodes onto superpeers, VSM supports existing consistency control to enable scalable, load balanced, and fault tolerant VE state management. As both client and server-side resources are utilized collaboratively, VSM also integrates both client-server and peer-to-peer VE designs in a unified approach.
6LoWPAN security: adding compromise resilience to the 802.15.4 security sublayer

6LoWPAN is a protocol stack for seamlessly integrating 802.15. 4-based wireless sensor networks with IPv6 networks. The security of 6LoWPAN widely depends on the 802.15. 4 security sublayer. This sublayer also supports pairwise keys so as to mitigate node compromises. Currently, the establishment of pairwise keys is however unspecified. Moreover, broadcast keys are shared among multiple nodes, which is not compromise resilient. In this paper, we propose two energy-efficient and DoS-resilient 802.15. 4 add-ons to fill these gaps: First, a pairwise key establishment scheme, which is adaptable to different 6LoWPAN networks and threat models. Second, an easy-to-implement and compromise-resilient protocol for authenticating broadcast frames. Together, our add-ons contain the effects of node compromises and provide a basis for detecting compromised nodes autonomously. We implemented both add-ons in Contiki and tested them on TelosB motes.
The Case for Service Provider Deployment of Super-Peers in Peer-to-Peer Networks

Peer-to-peer systems have recently introduced the notion of super-peers to improve search performance. While the benefit to end users is clear, it is not immediately evident who, if anyone, would be motivated to act as a super-peer. On the face of it, super-peers bear a much larger traffic burden than normal peers and receive negligible improvement in search performance when compared to any of the nodes they serve. In this paper we present incentives for several actors to deploy super-peers and propose a novel technical mechanism, topic-based search optimization, to increase the effectiveness of super-peers. By caching meta data— as opposed to content—at super-peers, topic-based search optimization has the potential to significantly improve the perceived search performance of a super-peer’s clients with very modest storage and communication overhead at the super-peer itself.
Entropy, Perception, and Relativity

Abstract : In this paper, I expand Shannon's definition of entropy into a new form of entropy that allows integration of information from different random events. Shannon's notion of entropy is a special case of my more general definition of entropy. I define probability using a so-called performance function, which is de facto an exponential distribution. Assuming that my general notion of entropy reflects the true uncertainty about a probabilistic event, I understand that our perceived uncertainty differs. I claim that our perception is the result of two opposing forces similar to the two famous antagonists in Chinese philosophy: Yin and Yang. Based on this idea, I show that our perceived uncertainty matches the true uncertainty in points determined by the golden ratio. I demonstrate that the well-known sigmoid function, which we typically employ in artificial neural networks as a non-linear threshold function, describes the actual performance. Furthermore, I provide a motivation for the time dilation in Einstein's Special Relativity, basically claiming that although time dilation conforms with our perception, it does not correspond to reality. At the end of the paper, I show how to apply this theoretical framework to practical applications. I present recognition rates for a pattern recognition problem, and also propose a network architecture that can take advantage of general entropy to solve complex decision problems.
Characterization of Peripheral Regulatory CD4+ T Cells That Prevent Diabetes Onset in Nonobese Diabetic Mice1

The period that precedes onset of insulin-dependent diabetes mellitus corresponds to an active dynamic state in which pathogenic autoreactive T cells are kept from destroying β cells by regulatory T cells. In prediabetic nonobese diabetic (NOD) mice, CD4+ splenocytes were shown to prevent diabetes transfer in immunodeficient NOD recipients. We now demonstrate that regulatory splenocytes belong to the CD4+ CD62Lhigh T cell subset that comprises a vast majority of naive cells producing low levels of IL-2 and IFN-γ and no IL-4 and IL-10 upon in vitro stimulation. Consistently, the inhibition of diabetes transfer was not mediated by IL-4 and IL-10. Regulatory cells homed to the pancreas and modified the migration of diabetogenic to the islets, which resulted in a decreased insulitis severity. The efficiency of CD62L+ T cells was dose dependent, independent of sex and disease prevalence. Protection mechanisms did not involve the CD62L molecule, an observation that may relate to the fact that CD4+ CD62Lhigh lymph node cells were less potent than their splenic counterparts. Regulatory T cells were detectable after weaning and persist until disease onset, sustaining the notion that diabetes is a late and abrupt event. Thus, the CD62L molecule appears as a unique marker that can discriminate diabetogenic (previously shown to be CD62L−) from regulatory T cells. The phenotypic and functional characteristics of protective CD4+ CD62L+ cells suggest they are different from Th2-, Tr1-, and NK T-type cells, reported to be implicated in the control of diabetes in NOD mice, and may represent a new immunoregulatory population.
Tensile response of steel/CFRP adhesive bonds for the rehabilitation of civil structures

There is a growing need for the development and implementation of new methods for the rapid and cost-effective rehabilitation of deteriorating steel structural components to offset the drawbacks related to welding and/or bolting in the field. Carbon fiber reinforced polymer (CFRP) composites provide a potential alternative as externally bonded patches for strengthening and repair of metallic structural members for building and bridge systems. This paper describes results of an investigation of tensile and fatigue response of steel/CFRP joints simulating scenarios of strengthening and crack-patching. It is shown that appropriately designed schemes, even when fabricated with levels of inaccuracy as could be expected in the field, can provide significant strain relief and load transfer capability. A simplified elasto-plastic closed form solution for stress analysis is presented, and validated experimentally. It is shown that the bond development length remains constant in the linear range, whereas it increases as the adhesive is deformed plastically. Fatigue resistance is shown to be at least comparable with the requirements for welded cover plates without attendant decreases in stiffness and strength.
Regulation of a renal urea transporter with reduced salinity in a marine elasmobranch, Raja erinacea

SUMMARY Marine elasmobranchs retain urea and other osmolytes, e.g. trimethylamine oxide (TMAO), to counterbalance the osmotic pressure of seawater. We investigated whether a renal urea transporter(s) would be regulated in response to dilution of the external environment. A 779 bp cDNA for a putative skate kidney urea transporter (SkUT) was cloned, sequenced and found to display relatively high identity with facilitated urea transporters from other vertebrates. Northern analysis using SkUT as a probe revealed three signals in the kidney at 3.1, 2.8 and 1.6 kb. Upon exposure to 50% seawater, the levels of all three SkUT transcripts were significantly diminished in the kidney (by 1.8- to 3.5-fold). In response to environmental dilution, renal tissue osmolality and urea concentration decreased, whereas water content increased. There were no significant differences in osmolyte and mRNA levels between the dorsal–lateral bundle and ventral sections of the kidney. Taken together, these findings provide evidence that the downregulation of SkUT may play a key role in lowering tissue urea levels in response to external osmolality.
Formal Languages: Origins and Directions

Origins of the theory of formal languages and automata are surveyed starting from 1936 with the work of Turing and Post. Special attention is given to the machine translation projects of the 1950s and early 1960s and associated work in mathematical linguistics. The development of the Chomsky hierarchy of grammars, machines, and languages from 1956 to 1964 is traced. It is observed that the same important ideas emerged independently for the automatic analysis and translation of both natural and artificial languages. Since 1964, formal language theory is part of theoretical computer science. A few of the directions since 1964 are considered: restrictions and extensions of context-free grammars and pushdown store automata, unifying frameworks, and complexity questions.
Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade

ABSTRACT Rap2 is a member of the Ras family of GTPases and exhibits 60% identity to Rap1, but the function and regulation of Rap2 remain obscure. We found that, unlike the other Ras family proteins, the GTP-bound active form exceeded 50% of total Rap2 protein in adherent cells. Guanine nucleotide exchange factors (GEFs) for Rap1, C3G, Epac (or cyclic AMP [cAMP]-GEF), CalDAG-GEFI, PDZ-GEF1, and GFR efficiently increased the level of GTP-Rap2 both in 293T cells and in vitro. GTPase-activating proteins (GAPs) for Rap1, rap1GAPII and SPA-1, stimulated Rap2 GTPase, but with low efficiency. The half-life of GTP-Rap2 was significantly longer than that of GTP-Rap1 in 293T cells, indicating that low sensitivity to GAPs caused a high GTP/GDP ratio on Rap2. Rap2 bound to the Ras-binding domain of Raf and inhibited Ras-dependent activation of Elk1 transcription factor, as did Rap1. The level of GTP-Rap2 in rat 3Y1 fibroblasts was decreased by the expression of v-Src, and expression of a GTPase-deficient Rap2 mutant inhibited v-Src-dependent transformation of 3Y1 cells. Altogether, Rap2 is regulated by a similar set of GEFs and GAPs as Rap1 and functions as a slowly responding molecular switch in the Rap1 signaling cascade.
Donor-Control of Scavenging Food Webs at the Land-Ocean Interface

Food webs near the interface of adjacent ecosystems are potentially subsidised by the flux of organic matter across system boundaries. Such subsidies, including carrion of marine provenance, are predicted to be instrumental on open-coast sandy shores where in situ productivity is low and boundaries are long and highly permeable to imports from the sea. We tested the effect of carrion supply on the structure of consumer dynamics in a beach-dune system using broad-scale, repeated additions of carcasses at the strandline of an exposed beach in eastern Australia. Carrion inputs increased the abundance of large invertebrate scavengers (ghost crabs, Ocypode spp.), a numerical response most strongly expressed by the largest size-class in the population, and likely due to aggregative behaviour in the short term. Consumption of carrion at the beach-dune interface was rapid and efficient, driven overwhelmingly by facultative avian scavengers. This guild of vertebrate scavengers comprises several species of birds of prey (sea eagles, kites), crows and gulls, which reacted strongly to concentrations of fish carrion, creating hotspots of intense scavenging activity along the shoreline. Detection of carrion effects at several trophic levels suggests that feeding links arising from carcasses shape the architecture and dynamics of food webs at the land-ocean interface.
Incomplete remission in depression: role of psychiatric and somatic comorbidity

Depression is one of the most pressing public health issues, because of its high lifetime prevalence and because it is associated with substantial disability. In depressed patients, psychiatric and medical comorbidity is the rule rather than the exception. About 60% to 70% of depressed patients have at least one, while 30% to 40% have two or more, concurrent psychiatric disorders. Among these, anxiety disorders and substance use disorders are the most common axis I comorbidities. Furthermore, two thirds of depressed patients have at least one comorbid medical illness. Among depressed patients, those with a current comorbid psychiatric condition (in particular an anxiety or substance use disorder) or medical illness seem to have an impaired response and remission rate during treatment compared with those patients without comorbidity. However, in depressed patients who all have the same comorbid condition, the relative benefit of an antidepressant compared with placebo appears to be equal to those effects achieved in depressed patients without comorbidity. These findings raise important research and treatment issues regarding the generalizability from randomized controlled trials that tend to exclude patients with comorbidity.
Hyperhomocysteinemia activates NF-kappaB and inducible nitric oxide synthase in the kidney.

BACKGROUND Hyperhomocysteinemia is an independent risk factor for cardiovascular disorders. Injury of multiple organs, including the kidney, was observed in hyperhomocysteinemic individuals. Activation of a transcription factor, namely, nuclear factor kappa B (NF-kappaB), plays an important role in inflammatory response and can exacerbate organ injury. The objective of the present study was to investigate the effect of hyperhomocysteinemia on renal NF-kappaB activation and the consequence of such activation. METHODS Hyperhomocysteinemia was induced in Sprague-Dawley rats after 4 weeks of a high-methionine diet. Activation of NF-kappaB was determined by electrophoretic mobility shift assay. Role of inhibitor protein IkappaBalpha was examined by Western immunoblotting analysis. RESULTS There was a significant increase in the level of phosphorylated IkappaBalpha protein in kidneys of hyperhomocysteinemic rats. This resulted in a decrease in the IkappaBalpha protein level leading to NF-kappaB activation. As a consequence, the expression of inducible nitric oxide synthase (iNOS) mRNA and protein was significantly elevated in kidneys of hyperhomocysteinemic rats. Increased nitric oxide production (150% of the control) resulted in peroxynitrite formation in these kidneys. Pretreatment of rats with a NF-kappaB inhibitor not only abolished NF-kappaB activation, but also reversed hyperhomocysteinemia-induced iNOS expression in the kidney. CONCLUSION Hyperhomocysteinemia alone can activate NF-kappaB and hence induce iNOS-mediated nitric oxide production in the kidney leading to increased peroxynitrite formation. This may represent one of the mechanisms for renal dysfunction in hyperhomocysteinemia.
CFD simulations of flow and heat transfer through the porous interface of a metal foam heat exchanger

This paper offers numerical modelling of a waste heat recovery system. A thin layer of metal foam is attached to a cold plate to absorb heat from hot gases leaving the system. The heat transferred from the exhaust gas is then transferred to a cold liquid flowing in a secondary loop. Two different foam PPI (Pores Per Inch) values are examined over a range of fluid velocities. Numerical results are then compared to both experimental data and theoretical results available in the literature. Challenges in getting the simulation results to match those of the experiments are addressed and discussed in detail. In particular, interface boundary conditions specified between a porous layer and a fluid layer are investigated. While physically one expects much lower fluid velocity in the pores compared to that of free flow, capturing this sharp gradient at the interface can add to the difficulties of numerical simulation. The existing models in the literature are modified by considering the pressure gradient inside and outside the foam. Comparisons against the numerical modelling are presented. Finally, based on experimentally-validated numerical results, thermo-hydraulic performance of foam heat exchangers as waste heat recovery units is discussed with the main goal of reducing the excess pressure drop and maximising the amount of heat that can be recovered from the hot gas stream.
Sex Differences in the Heritability of Resilience

Abstract We examine the heritability of psychological resilience among US adults aged 25 to 74 years. Using monozygotic and same sex dizygotic twin pairs from the National Survey of Mid-Life Development in the United States (MIDUS) we show that positive affect is equally heritable among men (h2 = .60) and women (h2 = .59). We then estimate the heritability of positive affect after controlling for an exhaustive list of social and inter-personal stressors, and we operationalize the residual for positive affect as resilience. According to this specification, the heritability of resilience is higher among men (h2 = .52) compared to women (h2 = .38). We show that self-acceptance is one of the most important aspects of psychological functioning that accounts for the heritability of resilience among both men and women. However, compared to women, men appear to derive additional benefits from environmental mastery that may enable otherwise sex-neutral resilient tendencies to manifest.
Role of adenosine in oligodendrocyte precursor maturation

Differentiation and maturation of oligodendroglial cells are postnatal processes that involve specific morphological changes correlated with the expression of stage-specific surface antigens and functional voltage-gated ion channels. A small fraction of oligodendrocyte progenitor cells (OPCs) generated during development are maintained in an immature and slowly proliferative or quiescent state in the adult central nervous system (CNS) representing an endogenous reservoir of immature cells. Adenosine receptors are expressed by OPCs and a key role of adenosine in oligodendrocyte maturation has been recently recognized. As evaluated on OPC cultures, adenosine, by stimulating A1 receptors, promotes oligodendrocyte maturation and inhibits their proliferation; on the contrary, by stimulating A2A receptors, it inhibits oligodendrocyte maturation. A1 and A2A receptor-mediated effects are related to opposite modifications of outward delayed rectifying membrane K+ currents (IK) that are involved in the regulation of oligodendrocyte differentiation. Brain A1 and A2A receptors might represent new molecular targets for drugs useful in demyelinating pathologies, such as multiple sclerosis (MS), stroke and brain trauma.
The effect of aromatase inhibitor letrozole incorporated in gonadotrophin-releasing hormone antagonist multiple dose protocol in poor responders undergoing in vitro fertilization

Objective To evaluate whether letrozole incorporated in a gonadotrophin-releasing hormone (GnRH) antagonist multiple dose protocol (MDP) improved controlled ovarian stimulation (COS) and in vitro fertilization (IVF) results in poor responders who underwent IVF treatment. Methods In this retrospective cohort study, a total of 103 consecutive IVF cycles that were performed during either the letrozole/GnRH antagonist MDP cycles (letrozole group, n=46) or the standard GnRH antagonist MDP cycles (control group, n=57) were included in 103 poor responders. COS results and IVF outcomes were compared between the two groups. Results Total dose and days of recombinant human follicle stimulating hormone (rhFSH) administered were significantly fewer in the letrozole group than in the control group. Duration of GnRH antagonist administered was also shorter in the letrozole group. The number of oocytes retrieved was significantly higher in the letrozole group. However, clinical pregnancy rate per cycle initiated, clinical pregnancy rate per embryo transfer, embryo implantation rate and miscarriage rate were similar in the two groups. Conclusion The letrozole incorporated in GnRH antagonist MDP may be more effective because it results comparable pregnancy outcomes with shorter duration and smaller dose of rhFSH, when compared with the standard GnRH antagonist MDP.