Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Mobile Devices for Teaching Realistic Mathematics in Kindergarten Education

New ICT tools allow children to take advantage of new learning platforms as well aiding them effectively in attaining new knowledge through activities related to their immediate interests and real life scenarios. Nowadays, computers and digital applications are a part of the daily life of children. In kindergarten education, properly designed digital educational activities can become a very powerful educational tool for efficient and effective learning. The utilization of interactive activities may contribute towards the growth of learning incentives as well as proper mental development in particular areas; such as mathematics and science. Mobile devices have new attractive features and provide considerable advantages in the teaching of mathematics in kindergarten education. Our study proposes the integration of mobile devices, running our own specially designed learning activity applications, in kindergarten classrooms. These applications are based on the three levels of Realistic Mathematics Education (RME) targeting fundamental mathematical concepts for the kindergarten level. We intend to gather information on effectiveness of the incorporation of these devices and applications as leaning tools for kindergarteners.
Lycium barbarum Polysaccharide Promotes Maturation of Dendritic Cell via Notch Signaling and Strengthens Dendritic Cell Mediated T Lymphocyte Cytotoxicity on Colon Cancer Cell CT26-WT

Lycium barbarum polysaccharide (LBP) is the major function component of Lycium barbarum L. and has been previously reported to induce the phenotypic and functional maturation of dendritic cells (DCs) as well as activating T lymphocytes. In the current study, the immunologic cytotoxicity promoting effect of LBP was assessed and the underlying mechanism was explored. The impact of LBP on the phenotype, maturation, and immunogenicity of DCs was assessed. The activity of Notch pathway which is involved in the regulation of LBP on DCs was detected. Afterwards, the influence of LBP on cytotoxicity of DC-mediated cytotoxicity T lymphocytes (CTLs) to CT26-WT colon cancer cells was further assessed. Administration of LBP induced the phenotypic and functional maturation of DCs. After being subjected to LBP, the expression of Notch and Jagged and Notch targets Hes1 and Hes5 was all upregulated. The cytotoxicity of DC-mediated CTLs was strengthened by administration of LBP. Additionally, cytotoxicity of DC-mediated CTLs on CT26-WT colon cancer cells also increased with effector-target ratio. In conclusion, LBP could induce the phenotypic and functional maturation of DCs via Notch signaling and promote the cytotoxicity of DC-mediated CTLs, which could be employed as a promising adjuvant for cancer immunotherapy.
Mode II fracture toughening and healing of composites using supramolecular polymer interlayers

This study focuses on the transfer of the healing functionality of supramolecular polymers (SP) to fibre reinforced composites through interleaving. SPs exhibiting self-healing based on hydrogen bonds were formed into films and were successfully incorporated into carbon fibre composites. The effect of the SP interleaves on in-plane fracture toughness and the subsequent healing capability of the hybrid composites were investigated under mode II fracture loading. The fracture toughness showed considerable increase since the maximum load (P max ) of the hybrid composite approximately doubled, and consequently the mode II interlaminar fracture toughness energy (G IIC ) exhibited an increase reaching nearly 100% compared to the reference composite. The healing component was activated using external heat. P max and G IIC recovery after activation were measured, exhibiting a healing efficiency after the first healing cycle close to 85% for P max and 100% for G IIC , eventually dropping to 80% for P max while G IIC was retained around 100% even after the fourth healing cycle. Acoustic Emission activity during the tests was monitored and was found to be strongly reduced due to the presence of the SP.
Capturing the Complexity in Advanced Technology Use: Adaptive Structuration Theory

The past decade has brought advanced information technologies, which include electronic messaging systems, executive information systems, collaborative systems, group decision support systems, and other technologies that use sophisticated information management to enable multiparty participation in organization activities. Developers and users of these systems hold high hopes for their potential to change organizations for the better, but actual changes often do not occur, or occur inconsistently. We propose adaptive structuration theory (AST) as a viable approach for studying the role of advanced information technologies in organization change. AST examines the change process from two vantage points: (1) the types of structures that are provided by advanced technologies, and (2) the structures that actually emerge in human action as people interact with these technologies. To illustrate the principles of AST, we consider the small group meeting and the use of a group decision support system (GDSS). A GDSS is an interesting technology for study because it can be structured in a myriad of ways, and social interaction unfolds as the GDSS is used. Both the structure of the technology and the emergent structure of social action can be studied.We begin by positioning AST among competing theoretical perspectives of technology and change. Next, we describe the theoretical roots and scope of the theory as it is applied to GDSS use and state the essential assumptions, concepts, and propositions of AST. We outline an analytic strategy for applying AST principles and provide an illustration of how our analytic approach can shed light on the impacts of advanced technologies on organizations. A major strength of AST is that it expounds the nature of social structures within advanced information technologies and the key interaction processes that figure in their use. By capturing these processes and tracing their impacts, we can reveal the complexity of technology-organization relationships. We can attain a better understanding of how to implement technologies, and we may also be able to develop improved designs or educational programs that promote productive adaptations.
V4 lesions in macaques affect both single- and multiple-viewpoint shape discriminations

The role of cortical area V4 in complex shape discriminations was studied by testing the effects of V4 lesions in macaques on the ability to visually discriminate between images of three-dimensional (3D) objects from different viewpoints. Stimuli were presented in pairs in the lower left or lower right visual field quadrants about 4 deg from the fovea, and the monkeys judged on each trial whether the two views were of the same or of different objects. Object similarity was varied to determine a threshold shape difference. V4 lesions caused profound, retinotopic, and apparently permanent disruptions of discrimination, regardless of whether the images represented single or multiple viewpoints. In V4 lesioned portions of the visual field, monkeys could discriminate objects only when they differed much more grossly in shape than was true in control locations. These effects of the lesion were virtually identical for discriminations that had been learned before lesions were placed and for those learned afterwards. As in previous studies, V4 lesions elevated contrast thresholds by approximately a factor of two, but control observations showed that this was not the basis of the disruption of shape discrimination. Manipulation of cues to shape showed that in control locations, monkeys maintained excellent shape discrimination despite a variety of stimulus alterations, whereas in V4 lesioned areas their performance was easily disrupted. This finding suggests that V4 may support visual shape discriminations by facilitating the use of multiple visual cues. However, the fact that single-viewpoint and multiple-viewpoint discriminations were similarly affected indicates that the disruption was not specific to 3D shape discrimination, but may apply to a variety of subtle discriminations.
Comparison of Feature Detection and Matching Approaches: SIFT and SURF

Feature detection and matching are used in image registration, object tracking, object retrieval etc. There are number of approaches used to detect and matching of features as SIFT (Scale Invariant Feature Transform), SURF (Speeded up Robust Feature), FAST, ORB etc. SIFT and SURF are most useful approaches to detect and matching of features because of it is invariant to scale, rotate, translation, illumination, and blur. In this paper, there is comparison between SIFT and SURF approaches are discussed. SURF is better than SIFT in rotation invariant, blur and warp transform. SIFT is better than SURF in different scale images. SURF is 3 times faster than SIFT because using of integral image and box filter. SIFT and SURF are good in illumination changes images.
POLYMER-MATRIX NANOCOMPOSITES, PROCESSING, MANUFACTURING AND APPLICATION: AN OVERVIEW

This review is a relative source for polymer nano composite research, which includes the fundamental properties, different manufacturing methods and various applications of polymer nanocomposite materials. this review article mainly focuses on the various scientific principles and mechanisms which are related to the methods of formulating and processing with a discussion on various commercial applications and also on various health/safety concerns (a major problem for manufacturing and scale-up). Hence, the relative discussion on technology, modeling, characterization, processing, manufacturing, applications and health/safety concerns for polymer nanocomposites is over viewed in this article.
Crystal Loss and Quality Pooling for Unconstrained Face Verification and Recognition

In recent years, the performance of face verification and recognition systems based on deep convolutional neural networks (DCNNs) has significantly improved. A typical pipeline for face verification includes training a deep network for subject classification with softmax loss, using the penultimate layer output as the feature descriptor, and generating a cosine similarity score given a pair of face images or videos. The softmax loss function does not optimize the features to have higher similarity score for positive pairs and lower similarity score for negative pairs, which leads to a performance gap. In this paper, we propose a new loss function, called Crystal Loss, that restricts the features to lie on a hypersphere of a fixed radius. The loss can be easily implemented using existing deep learning frameworks. We show that integrating this simple step in the training pipeline significantly improves the performance of face verification and recognition systems. We achieve state-of-the-art performance for face verification and recognition on challenging LFW, IJB-A, IJB-B and IJB-C datasets over a large range of false alarm rates (10-1 to 10-7).
GATA4 Variants in Individuals With a 46,XY Disorder of Sex Development (DSD) May or May Not Be Associated With Cardiac Defects Depending on Second Hits in Other DSD Genes

Disorders of sex development (DSD) consist of a wide range of conditions involving numerous genes. Nevertheless, about half of 46,XY individuals remain genetically unsolved. GATA4 gene variants, mainly related to congenital heart defects (CHD), have also been recently associated with 46,XY DSD. In this study, we characterized three individuals presenting with 46,XY DSD with or without CHD and GATA4 variants in order to understand the phenotypical variability. We studied one patient presenting CHD and 46,XY gonadal dysgenesis, and two patients with a history of genetically unsolved 46,XY DSD, also known as male primary hypogonadism. Mutation analysis was carried out by candidate gene approach or targeted gene panel sequencing. Functional activity of GATA4 variants was tested in vitro on the CYP17 promoter involved in sex development using JEG3 cells. We found two novel and one previously described GATA4 variants located in the N-terminal zinc finger domain of the protein. Cys238Arg variant lost transcriptional activity on the CYP17 promoter reporter, while Trp228Cys and Pro226Leu behaved similar to wild type. These results were in line with bioinformatics simulation studies. Additional DSD variations, in the LRP4 and LHCGR genes, respectively, were identified in the two 46,XY individuals without CHD. Overall, our study shows that human GATA4 mutations identified in patients with 46,XY DSD may or may not be associated with CHD. Possible explanations for phenotypical variability may comprise incomplete penetrance, variable sensitivity of partner genes, and oligogenic mechanisms.
The effect of an eye health promotion program on the health protective behaviors of primary school students

INTRODUCTION: Undiagnosed and uncorrected refractive errors in childhood can negatively affect the development of vision and cause students to have low academic success and even quit school before graduation. This study aims to determine the effects of an eye health promotion program on the health protective behaviors of primary school students. MATERIALS AND METHODS: This experimental study using a pretest-posttest design with a control group was conducted in three public primary schools in Aydın, a city in the Western Anatolia Region of Turkey, between April and November 2014. The eye health promotion program was provided by the researchers to the experimental Group 2 days in 4 weeks. The data were analyzed using the t-test, Chi-square analysis, the Mann–Whitney U-test, the Wilcoxon signed-rank test, and the McNemar test. RESULTS: The average age of the students was identified as 9.0 ± 3.64 years. The students wearing glasses all in the experimental group and 53.3% in the control group were found to always wear their glasses after the education program was completed (P < 0.05). These students, 97.9% in the experimental group and 58.1% in the control group underwent eye examinations from an ophthalmologist (P < 0.05). The eye health protective behaviors of the experimental group were found to have positively changed in the final follow-up, compared to the control group (P < 0.05). CONCLUSION: The eye health promotion program was found to be effective in improving eye health protective behaviors within the experimental group.
Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines

The most common mutation of CFTR, affecting approximately 90% of CF patients, is a deletion of phenylalanine at position 508 (F508del, ΔF508). Misfolding of ΔF508-CFTR impairs both its trafficking to the plasma membrane and its chloride channel activity. To identify small molecules that can restore channel activity of ΔF508-CFTR, we synthesized and evaluated eighteen novel hydroxypyrazoline analogues as CFTR potentiators. To elucidate potentiation activities of hydroxypyrazolines for ΔF508-CFTR, CFTR activity was measured using a halide-sensitive YFP assay, Ussing chamber assay and patch-clamp technique. Compounds 7p, 7q and 7r exhibited excellent potentiation with EC50 value <10 μM. Among the compounds, 7q (a novel CFTR potentiator, CP7q) showed the highest potentiation activity with EC50 values of 0.88 ± 0.11 and 4.45 ± 0.31 μM for wild-type and ΔF508-CFTR, respectively. In addition, CP7q significantly potentiated chloride conductance of G551D-CFTR, a CFTR gating mutant; its maximal potentiation activity was 1.9 fold higher than the well-known CFTR potentiator genistein. Combination treatment with CP7q and VX-809, a corrector of ΔF508-CFTR, significantly enhanced functional rescue of ΔF508-CFTR compared with VX-809 alone. CP7q did not alter the cytosolic cAMP level and showed no cytotoxicity at the concentration showing maximum efficacy. The hydroxypyrazolines may be potential development candidates for drug therapy of cystic fibrosis.
Redistribution of caveolae during mitosis

Caveolae form a specialized platform within the plasma membrane that is crucial for an array of important biological functions, ranging from signaling to endocytosis. Using total internal reflection fluorescence (TIRF) and 3D fast spinning-disk confocal imaging to follow caveola dynamics for extended periods, and electron microscopy to obtain high resolution snapshots, we found that the vast majority of caveolae are dynamic with lifetimes ranging from a few seconds to several minutes. Use of these methods revealed a change in the dynamics and localization of caveolae during mitosis. During interphase, the equilibrium between the arrival and departure of caveolae from the cell surface maintains the steady-state distribution of caveolin-1 (Cav1) at the plasma membrane. During mitosis, increased dynamics coupled to an imbalance between the arrival and departure of caveolae from the cell surface induces a redistribution of Cav1 from the plasma membrane to intracellular compartments. These changes are reversed during cytokinesis. The observed redistribution of Cav1 was reproduced by treatment of interphase cells with nocodazole, suggesting that microtubule rearrangements during mitosis can mediate caveolin relocalization. This study provides new insights into the dynamics of caveolae and highlights precise regulation of caveola budding and recycling during mitosis.
Characteristics of Nutrient Uptake and Utilization of Super Hybrid Rice Under Different Fertilizer Application Rates

【Objective】Characteristics of nitrogen (N), phosphors (P) and potassium (K) uptake and their utilization of super hybrid rice were studied. 【Method】 Field experiments with super hybrid rice Zhunliangyou 527 and Liangyou 293 were conducted in five locations of Hunan province in 2004 and 2005. Fertilizer application rates were designed as the treatments of low rate (135 kg N·ha-1, 29.7 kg P·ha-1, 112.1 kg K·ha-1), medium rate (180 kg N·ha-1, 39.6 kg P·ha-1, 149.4 kg K·ha-1) and high rate ( 225 kg N·ha-1, 49.5 kg P·ha-1, 186.8 kg K·ha-1) by using randomized complete block design with 4 replications. Aboveground plants were sampled to measure the dry matter weight, NPK content, NPK uptake rate, NPK harvest index and nutrient use efficiency at heading and maturity stage. 【Result】 No significant differences of plant NPK content at heading and maturity stage were found between two tested varieties and among 3 fertilizer application rates. And the variation range of plant NPK content among 5 locations was relatively smaller than that of the actual yield as well as the NPK uptake rate. The differences of plant NPK uptake rates among the locations were mainly due to the differences of the dry matter production. With the increase of the actual yield, the harvest index of NPK showed an increased tendency and the requirements for NPK nutrients to produce 1 000 kg grain yield showed a declined tendency. The highest actual yield was recorded in Guidong site but the plant NPK nutrient content and their uptake rates were at the medium level among 5 locations. 【Conclusion】 There was no significant differences in plant NPK content and uptake rate for super hybrid rice in the range of fertilizer application rates of 135-225 kg N·ha-1, 29.7- 49.5 kg P·ha-1, 112.1-186.8 kg K·ha-1. With the increase of actual yield of super hybrid rice, the uptake and use efficiency of fertilizer NPK nutrients increased. Therefore, thehigh use efficiency of fertilizer nutrients was associated with the high yield performance of super hybrid rice.
Reflectance variation in the blue tit crown in relation to feather structure

ABSTRACT Structural plumage colour is one of the most enigmatic sexually selected traits. The information content of structural colour variation is debated, and the heterogeneity of the findings is hard to explain because the proximate background of within-species colour differences is very scarcely studied. We combined measurements of feather macrostructure and nanostructure to explain within-population variability in blue tit crown reflectance. We found that sexual dichromatism in aspects of crown reflectance was explained only by feather macrostructure, whereas nanostructural predictors accounted for some of the age-related differences in reflectance. Moreover, we found that both mean reflectance and spectral shape traits reflected a combination of quantity and regularity aspects in macrostructure and nanostructure. This rich proximate background provides ample scope for reflectance to convey various types of information on individual quality. Summary: Using spectrometry, photographic analysis of feather macrostructure and transmission electron microscopy, we detect a previously unappreciated role for macrostructure in explaining individual differences in structural plumage colour.
The Serotonin Transporter Gene Polymorphisms and Risk of Ischemic Stroke

Introduction: Serotonin is known as a neurotransmitter; however, it also plays an important role in platelet aggregation as it is released upon platelet activation. The serotonin transporter (SERT) is responsible for the uptake of serotonin into platelets. Functional polymorphisms in the SERT gene may influence platelet activity, as they result in different levels of transporters and thereby different levels of serotonin in platelets. SERT gene polymorphisms have thus been associated with the risk of myocardial infarction. A similar association may exist between SERT gene polymorphisms and stroke. However, to our knowledge, this potential association has not previously been studied. We therefore aimed to investigate the association between polymorphisms in the SERT gene and the risk of ischemic stroke/transitory ischemic attack (TIA). Materials and Methods: We conducted a case-control study including 834 consecutively admitted first-ever Caucasian ischemic stroke patients/TIA from Aarhus University Hospital, Denmark and 571 healthy controls. The control group comprised a sample from the Danish working population, who were all employees in the public sector in the Central Denmark Region. Two polymorphisms, the length variation (short = S/long = L) in the serotonin-transporter-linked polymorphic region and a single-nucleotide (A/G) polymorphism (rs25531) were studied. The genotypes were grouped according to the functional activity: SS, SLG and LGLG (low expression), SLA, LGLA (medium expression), and LALA (high expression). Data were analyzed using logistic regression and results presented as OR with 95% CI. Results: The high-expression genotype was associated with a lower risk of ischemic stroke/TIA when compared to both the medium expression genotype (OR 0.72, 95% CI 0.56–0.93) and the low-expression genotype (OR 0.75, 95% CI 0.55–1.01) as well as the combination of the low and medium expression genotypes (OR 0.73, 95% CI 0.58–0.93). The lower OR estimates associated with the high-expression genotype were consistent across all stroke subtypes, although not statistically significant. The results remained virtually unchanged, although not reaching statistical significance, when adjusting for age and gender. Conclusion: The presence of the high expression SERT genotype (LALA) may be associated with a lower risk of ischemic stroke/TIA. This is, to our knowledge, the first study examining the SERT gene polymorphisms and the risk of stroke. The present results raise interesting considerations for future personalized medicine potential, and we argue that further larger-scale studies with sufficient power to study subgroups according to stroke etiology and stroke-onset age are needed.