Miracle-dz/UniFAR-FTUs huggingface dataset:
TBX21: A functional variant predicts improvement in asthma with the use of inhaled corticosteroids

TBX21 encodes for the transcription factor T-bet (T-box expressed in T cells), which influences naïve T lymphocyte development and has been implicated in asthma pathogenesis. Specifically, the T-bet knockout mouse spontaneously develops airway hyperresponsiveness and other changes consistent with asthma. Because airway responsiveness is moderated by the use of inhaled corticosteroids in asthma, it is conceivable that genetic variation in TBX21 may alter asthma phenotypes in a treatment-specific fashion. Here we demonstrate that the nonsynonymous variation in TBX21 coding for replacement of histidine 33 with glutamine is associated with significant improvement in the PC20 (a measure of airway responsiveness) of asthmatic children in a large clinical trial spanning 4 years. We note that this increase occurs only in the children randomized to inhaled corticosteroids and that it dramatically enhances the overall improvement in PC20 associated with inhaled corticosteroid usage. The average PC20 at trial end for subjects on inhaled corticosteroids possessing a variant allele was in the normal range for nonasthmatics. In cellular models, we show that the TBX21 variant increases T helper 1 and decreases T helper 2 cytokine expression comparably with wild type. TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids.
Nationwide longitudinal study of psychological responses to September 11.

CONTEXT The September 11, 2001, attacks against the United States provide a unique opportunity to examine longitudinally the process of adjustment to a traumatic event on a national scale. OBJECTIVE To examine the degree to which demographic factors, mental and physical health history, lifetime exposure to stressful events, September 11-related experiences, and coping strategies used shortly after the attacks predict psychological outcomes over time. DESIGN, SETTING, AND PARTICIPANTS A national probability sample of 3496 adults received a Web-based survey; 2729 individuals (78% participation rate) completed it between 9 and 23 days (75% within 9 to 14 days) after the terrorist attacks. A random sample of 1069 panelists residing outside New York, NY, were drawn from the wave 1 sample (n = 2729) and received a second survey; 933 (87% participation rate) completed it approximately 2 months following the attacks. A third survey (n = 787) was completed approximately 6 months after the attacks. MAIN OUTCOME MEASURES September 11-related symptoms of acute stress, posttraumatic stress, and global distress. RESULTS Seventeen percent of the US population outside of New York City reported symptoms of September 11-related posttraumatic stress 2 months after the attacks; 5.8% did so at 6 months. High levels of posttraumatic stress symptoms were associated with female sex (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.17-2.31), marital separation (OR, 2.55; 95% CI, 1.06-6.14), pre-September 11 physician-diagnosed depression or anxiety disorder (OR, 1.84; 95% CI, 1.33-2.56) or physical illness (OR, 0.93; 95% CI, 0.88-0.99), severity of exposure to the attacks (OR, 1.31; 95% CI, 1.11-1.55), and early disengagement from coping efforts (eg, giving up: OR, 1.68; 95% CI, 1.27-2.20; denial: OR, 1.33; 95% CI, 1.07-1.64; and self-distraction: OR, 1.31; 95% CI, 1.07-1.59). In addition to demographic and pre-September 11 health variables, global distress was associated with severity of loss due to the attacks (beta =.07; P =.008) and early coping strategies (eg, increased with denial: beta =.08; P =.005; and giving up: beta =.05; P =.04; and decreased with active coping: beta = -.08; P =.002). CONCLUSIONS The psychological effects of a major national trauma are not limited to those who experience it directly, and the degree of response is not predicted simply by objective measures of exposure to or loss from the trauma. Instead, use of specific coping strategies shortly after an event is associated with symptoms over time. In particular, disengaging from coping efforts can signal the likelihood of psychological difficulties up to 6 months after a trauma.
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—Traditional Kalman filter (KF) is derived under the well-known minimum mean square error (MMSE) criterion, which is optimal under Gaussian assumption. However, when the signals are non-Gaussian, especially when the system is disturbed by some heavy-tailed impulsive noises, the performance of KF will deteriorate seriously. To improve the robustness of KF against impulsive noises, we propose in this work a new Kalman filter, called the maximum correntropy Kalman filter (MCKF), which adopts the robust maximum correntropy criterion (MCC) as the optimality criterion, instead of using the MMSE. Similar to the traditional KF, the state mean and covariance matrix propagation equations are used to give prior estimations of the state and covariance matrix in MCKF. A novel fixed-point algorithm is then used to update the posterior estimations. A sufficient condition that guarantees the convergence of the fixed-point algorithm is given. Illustration examples are presented to demonstrate the effectiveness and robustness of the new algorithm.
Exploring the chicken embryo as a possible model for studying Listeria monocytogenes pathogenicity

Listeria monocytogenes is a bacterial pathogen capable of causing severe infections in humans, often with fatal outcomes. Many different animal models exist to study L. monocytogenes pathogenicity, and we have investigated the chicken embryo as an infection model: What are the benefits and possible drawbacks? We have compared a defined wild-type strain with its isogenic strains lacking well-characterized virulence factors. Our results show that wild-type L. monocytogenes, already at a relatively low infection dose (~5 × 102 cfu), caused death of the chicken embryo within 36 h, in contrast to strains lacking the main transcriptional activator of virulence, PrfA, or the cytolysin LLO. Surprisingly, strains lacking the major adhesins InlA and InlB caused similar mortality as the wild-type strain. In conclusion, our results suggest that the chicken embryo is a practical model to study L. monocytogenes infections, especially when analyzing alternative virulence pathways independent of the InlA and InlB adhesins. However, the route of infection might be different from a human infection. The chicken embryo model and other Listeria infection models are discussed.
Familial cancer associated with a polymorphism in ARLTS1.

BACKGROUND The finding of hemizygous or homozygous deletions at band 14 on chromosome 13 in a variety of neoplasms suggests the presence of a tumor-suppressor locus telomeric to the RB1 gene. METHODS We studied samples from 216 patients with various types of sporadic tumors or idiopathic pancytopenia, peripheral-blood samples from 109 patients with familial cancer or multiple cancers, and control blood samples from 475 healthy people or patients with diseases other than cancer. We performed functional studies of cell lines lacking ARLTS1 expression with the use of both the full-length ARLTS1 gene and a truncated variant. RESULTS We found a gene at 13q14, ARLTS1, a member of the ADP-ribosylation factor family, with properties of a tumor-suppressor gene. We analyzed 800 DNA samples from tumors and blood cells from patients with sporadic or familial cancer and controls and found that the frequency of a nonsense polymorphism, G446A (Trp149Stop), was similar in controls and patients with sporadic tumors but was significantly more common among patients with familial cancer than among those in the other two groups (P=0.02; odds ratio, 5.7; 95 percent confidence interval, 1.3 to 24.8). ARLTS1 was down-regulated by promoter methylation in 25 percent of the primary tumors we analyzed. Transfection of wild-type ARLTS1 into A549 lung-cancer cells suppressed tumor formation in immunodeficient mice and induced apoptosis, whereas transfection of truncated ARLTS1 had a limited effect on apoptosis and tumor suppression. Microarray analysis revealed that the wild-type and Trp149Stop-transfected clones had different expression profiles. CONCLUSIONS A genetic variant of ARLTS1 predisposes patients to familial cancer.
Static and dynamic pressure profiles of a patellar-tendon-bearing (PTB) socket

Abstract The purpose of this study was to evaluate the pressure distribution at the stump/socket interface in amputees wearing the patellar-tendon-bearing socket. A specially built strain gauged type pressure transducer was used for measuring this pressure distribution in four unilateral transtibial amputees. Pressure and gait parameters were measured simultaneously while they were standing and walking. Pressure profiles were compiled at 10, 25 and 50 per cent of gait cycle and compared with the pressure profiles predicted by Radcliffe in 1961. The subject's anterior-posterior pressure profiles were different from each other. However, at toe-off, each subject exhibited an increase in pressure at the patellar tendon. Their medial-lateral pressure profiles were similar: exhibiting high pressure at the medial proximal and lateral distal regions except for one subject who exhibited high pressure at the lateral proximal region instead. The subjects' pressure profiles did not resemble Radcliffe's anticipated pressure profiles. This was because ground reaction force was not the only factor affecting the resulting pressure profiles.
Sampling short lattice vectors and the closest lattice vector problem

We present a 2/sup O(n)/ time Turing reduction from the closest lattice vector problem to the shortest lattice vector problem. Our reduction assumes access to a subroutine that solves SVP exactly and a subroutine to sample short vectors from a lattice, and computes a (1+/spl epsi/)-approximation to CVP As a consequence, using the SVP algorithm from (Ajtai et al., 2001), we obtain a randomized 2[O(1+/spl epsi//sup -1/)n] algorithm to obtain a (1+/spl epsi/)-approximation for the closest lattice vector problem in n dimensions. This improves the existing time bound of O(n! ) for CVP achieved by a deterministic algorithm in (Blomer, 2000).
Hope, self-efficacy, spiritual well-being and job satisfaction.

TITLE Hope, self-efficacy, spiritual well-being and job satisfaction. AIM This paper is a report of a study of the relations of spiritual well-being, global job satisfaction, and general self-efficacy to hope in Continuing Care Assistants. BACKGROUND Healthcare providers have described their hope as an important part of their work and a form of work motivation. Hope may be an important factor in preventing burnout and improving job satisfaction. METHODS A concurrent triangulation mixed method design was used. Sixty-four Continuing Care Assistants (personal care aides) who registered for a 'Living with Hope' Conference completed a demographic form, Herth Hope Index, Global Job Satisfaction Questionnaire, Spiritual Well-Being Scale, General Self-Efficacy Scale, and a hope questionnaire. Data were collected in 2007. The response rate was 58%. RESULTS Using linear regression, 29.9% of the variance in Herth Hope Index score was accounted for by scores from the General Self-Efficacy Scale and Spiritual Well-Being Scale. General Self-efficacy scores (positive relationship) and Spiritual Well-Being scores (negative relationship) accounted for a significant part of the variance. Qualitative data supported all findings, with the exception of the negative relationship between hope and spiritual well-being; participants wrote that faith, relationships, helping others and positive thinking helped them to have hope. They also wrote that hope had a positive influence on their job satisfaction and performance. CONCLUSION Hope is an important concept in the work life of Continuing Care Assistants. Supportive relationships, adequate resources, encouragement by others, and improving perceptions of self-efficacy (ability to achieve goals in their workplace) may foster their hope.
Photonic generation of continuous THz wave using uni-traveling-carrier photodiode

A uni-traveling-carrier photodiode (UTC-PD) is monolithically integrated with a wideband log-periodic toothed antenna for generating millimeter and submillimeter waves at frequencies of up to terahertz range. A module with a quasi-optical output port fabricated for practical use operates up to 1.5 THz and generates an output power of 2.3 /spl mu/W at 1.04 THz with good linearity. The output power level and the operation frequency are records for wideband PD modules operating at 1.55 /spl mu/m. An investigation of the operational characteristics of the UTC-PD reveals that the effective use of the electron-velocity overshoot in the junction depletion layer is important for maximizing the output power in the terahertz range.
New method based on load flow with step size optimization for calculating the maximum loading point

In this paper, an improved maximum loading point (MLP) calculation method is proposed. The calculation process is based on the properties of the normal vector to the feasibility boundary computed close to MLP, which is calculated by a load flow method with step size optimization (LFSSO). The process is characterized by obtaining consecutive approximations of the MLP within the infeasible region. Since the feasibility boundary contour in the neighborhood of the MLP may not be smooth, some of the computed approximations may fall within the feasible region. In an earlier paper, a mechanism based on binary search was used to drive the operating point back to the infeasible region. A new load curtailment method to improve the proximity towards feasibility boundary guaranteeing that the next solution will lay within the infeasibility region is the main contribution of this paper. Reactive power generation limits are taken into account. The proposed formulation requires information as the normal vector and power mismatches, and results in a better convergence path towards MLP in comparison with the original version of the method presented earlier. Simulation results for IEEE test systems are shown to validate the proposed method.
Modeling and H∞ control for switched linear parameter-varying missile autopilot

This paper presents a new method for designing a gain-scheduled missile autopilot. The nonlinear missile dynamics are modeled as a switched linear parameter-varying (SLPV) system, as is also common for many hybrid system models. A gain-scheduled autopilot for the SLPV system is then designed using a new synthesis technique that is based on a nonsmooth dissipation framework. The proposed algorithm extends previously published Lyapunov-based LPV approaches in three important ways: the SLPV system can provide a more accurate model of the missile dynamics; the nonsmooth Lyapunov function used in the synthesis is a more general class of Lyapunov functions; and the gridding technique typically used to solve the synthesis can be eliminated from the problem. As a result, the new approach yields a reliable gain-scheduled autopilot with better performance than the LPV controllers available in the literature.
Customer involvement and new product performance: The jointly moderating effects of technological and market newness

Purpose The purpose of this paper is to examine the joint influence of technological newness (TN) and market newness (MN) on the relationship between customer involvement (CI) and new product performance. Design/methodology/approach The authors employed hierarchical moderated regression analysis to test the hypothesized relationships using survey data collected from 214 Chinese manufacturing firms. Findings The authors found that the impact of CI on new product performance varies across the different configurations of TN and MN. Specifically, the performance effect of CI is most positive under low TN and high MN, while the performance effect is least positive under low TN and low MN. Originality/value This study enriches CI research by identifying different configurations of product innovativeness that augment or limit the value of CI.
Bradyrhizobium japonicum does not require alpha-ketoglutarate dehydrogenase for growth on succinate or malate

The sucA gene, encoding the E1 component of alpha-ketoglutarate dehydrogenase, was cloned from Bradyrhizobium japonicum USDA110, and its nucleotide sequence was determined. The gene shows a codon usage bias typical of non-nif and non-fix genes from this bacterium, with 89.1% of the codons being G or C in the third position. A mutant strain of B. japonicum, LSG184, was constructed with the sucA gene interrupted by a kanamycin resistance marker. LSG184 is devoid of alpha-ketoglutarate dehydrogenase activity, indicating that there is only one copy of sucA in B. japonicum and that it is completely inactivated in the mutant. Batch culture experiments on minimal medium revealed that LSG184 grows well on a variety of carbon substrates, including arabinose, malate, succinate, beta-hydroxybutyrate, glycerol, formate, and galactose. The sucA mutant is not a succinate auxotroph but has a reduced ability to use glutamate as a carbon or nitrogen source and an increased sensitivity to growth inhibition by acetate, relative to the parental strain. Because LSG184 grows well on malate or succinate as its sole carbon source, we conclude that B. japonicum, unlike most other bacteria, does not require an intact tricarboxylic acid (TCA) cycle to meet its energy needs when growing on the four-carbon TCA cycle intermediates. Our data support the idea that B. japonicum has alternate energy-yielding pathways that could potentially compensate for inhibition of alpha-ketoglutarate dehydrogenase during symbiotic nitrogen fixation under oxygen-limiting conditions.
Frailty Syndrome: A Transitional State in a Dynamic Process

Frailty has long been considered synonymous with disability and comorbidity, to be highly prevalent in old age and to confer a high risk for falls, hospitalization and mortality. However, it is becoming recognized that frailty may be a distinct clinical syndrome with a biological basis. The frailty process appears to be a transitional state in the dynamic progression from robustness to functional decline. During this process, total physiological reserves decrease and become less likely to be sufficient for the maintenance and repair of the ageing body. Central to the clinical concept of frailty is that no single altered system alone defines it, but that multiple systems are involved. Clinical consensus regarding the phenotype which constitutes frailty, drawing upon the opinions of numerous authors, shows the characteristics to include wasting (loss of both muscle mass and strength and weight loss), loss of endurance, decreased balance and mobility, slowed performance, relative inactivity and, potentially, decreased cognitive function. Frailty is a distinct entity easily recognized by clinicians, with multiple manifestations and with no single symptom being sufficient or essential in its presentation. Manifestations include appearance (consistent or not with age), nutritional status (thin, weight loss), subjective health rating (health perception), performance (cognition, fatigue), sensory/physical impairments (vision, hearing, strength) and current care (medication, hospital). Although the early stages of the frailty process may be clinically silent, when depleted reserves reach an aggregate threshold leading to serious vulnerability, the syndrome may become detectable by looking at clinical, functional, behavioral and biological markers. Thus, a better understanding of these clinical changes and their underlying mechanisms, beginning in the pre-frail state, may confirm the impression held by many geriatricians that increasing frailty is distinguishable from ageing and in consequence is potentially reversible. We therefore provide an update of the physiopathology and clinical and biological characteristics of the frailty process and speculate on possible preventative approaches.
Queueing-based analysis of broadcast optical networks

We consider broadcast WDM networks operating with schedules that mask the transceiver tuning latency. We develop and analyze a queueing model of the network in order to obtain the queue-length distribution and the packet loss probability at the transmitting and receiving side of the nodes. The analysis is carried out assuming finite buffer sizes, non-uniform destination probabilities and two-state MMBP traffic sources; the latter naturally capture the notion of burstiness and correlation, two important characteristics of traffic in high-speed networks. We present results which establish that the performance of the network is a complex function of a number of system parameters, including the load balancing and scheduling algorithms, the number of available channels, and the buffer capacity. We also show that the behavior of the network in terms of packet loss probability as these parameters are varied cannot be predicted without an accurate analysis. Our work makes it possible to study the interactions among the system parameters, and to predict, explain and fine tune the performance of the network.
Consumer Informedness and Firm Information Strategy

Consumer informedness plays a critical role in determining consumer choice in the presence of information technology deployed by competing firms in the marketplace. This paper develops a new theory of consumer informedness. Using data collected through a series of stated choice experiments in two different research contexts, we examine how consumer characteristics and observed behaviors moderate the influence of price and product informedness on consumer choice. The results indicate that different types of consumer informedness amplify different consumer behaviors in specific consumer segments. In particular, we found that price informedness is more influential among consumers in the commodity segment. They exhibit greater trading down behavior, which represents stronger preferences for choosing the products that provide the best price. In contrast, product informedness is more influential among consumers in the differentiated segment. This group exhibits greater trading out behavior, involving stronger preferences for choosing products that best suit their specific needs. These results suggest that firm information strategy should take into account consumers' characteristics, their past observed behaviors, and the impact of consumer informedness. We also discuss the theoretical contributions of this research and its broader implications for firm-level information strategy.
User Association and Scheduling With Hard Deadlines in Heterogeneous Cellular Networks

This letter studies the problem of user association and scheduling in heterogeneous cellular networks under deadline constraints. The objective is to maximize the number of associated users while respecting these constraints. First, we discuss a special case of the problem and present an optimal algorithm. Second, we show that the problem is NP-hard in general and present a constant-factor approximation algorithm to solve it. Finally, we show via simulations that the proposed algorithm performs close-to-optimal and surpasses benchmark heuristic algorithms.