Miracle-dz/UniFAR-FTUs huggingface dataset:
Involvement of Phosphatases in Proliferation, Maturation, and Hemoglobinization of Developing Erythroid Cells

Production of RBCs is triggered by the action of erythropoietin (Epo) through its binding to surface receptors (Epo-R) on erythroid precursors in the bone marrow. The intensity and the duration of the Epo signal are regulated by several factors, including the balance between the activities of kinesase and phosphatases. The Epo signal determines the proliferation and maturation of the precursors into hemoglobin (Hb)-containing RBCs. The activity of various protein tyrosine phosphatases, including those involved in the Epo pathway, can be inhibited by sodium orthovanadate (Na3VO4, vanadate). Adding vanadate to cultured erythroid precursors of normal donors and patients with β-thalassemia enhanced cell proliferation and arrested maturation. This was associated with an increased production of fetal hemoglobin (HbF). Increased HbF in patients with β-hemoglobinopathies (β-thalassemia and sickle cell disease) ameliorates the clinical symptoms of the disease. These results raise the possibility that specific and nontoxic inhibitors of phosphatases may be considered as a therapeutic modality for elevating HbF in patients with β-hemoglobinopathies as well as for intensifying the Epo response in other forms of anemia.
The Impact of Relative Standards on the Propensity to Disclose

Two sets of studies illustrate the comparative nature of disclosure behavior. The first set investigates how divulgence is affected by signals about others' readiness to divulge and shows a “herding” effect: Survey respondents are more willing to divulge sensitive information when told that previous respondents have made sensitive disclosures (Study 1a). The authors provide evidence of the process underlying this effect and rule out alternative explanations by showing that information on others' propensity to disclose affects respondents' discomfort associated with divulgence (Study 1b) but not their interpretation of the questions (Study 1c). The second set of studies investigates how divulgence is affected by the order in which inquiries of varying intrusiveness are made and suggests that divulgence is anchored by the initial questions in a survey. People are particularly likely to divulge when questions are presented in decreasing order of intrusiveness and less likely when questions are presented in increasing order (Study 2a). The authors show that the effect arises by affecting people's judgments of the intrusiveness of the inquiries (Study 2b). The effect is altered when, at the outset of the study, privacy concerns are primed (Study 2c) and when respondents are made to consider the relative intrusiveness of a different set of questions (Study 2d). This research helps illuminate how consumers' propensity to disclose is affected by continual streams of requests for personal information and by the equally unavoidable barrage of personal information about others.
Reduced life expectancy in 40 cases of early onset cerebellar ataxia with retained tendon reflexes: a population‐based study

A survival analysis of 40 cases of early onset cerebellar ataxia (EOCA) with retained tendon reflexes was performed. They represent all cases of EOCA diagnosed between 1945 and 1990 among residents of a defined area of Northwestern Italy, followed up to December 31, 1990. The survival rates were respectively 92%, 87% and 77% at 10, 20 and 30‐years, worse than expected in a disease which is usually considered benign. The relative death rate was 4 times higher than expected for the general population. Prognosis was significantly worse for males than for females, whereas the age of onset and the calendar year of onset did not affect survival.
Localization of Function All Over Again

In this special issue of NeuroImage, five leading groups of investigators of human brain function have addressed a key issue of cerebral cortical functional organization, an issue that has been raised and settled in different ways at different times in the history of the brain sciences. The pendulum has swung from localization in the time of Gall and Spurzheim through Fritsch and Hitzig to equipotentiality in the time of Lashley. What is notable about the five sets of studies in this special issue is their focus on both localization issues in the prefrontal cortex and the interaction between noninvasive studies in humans and experimental research at the cellular level traditionally carried out in nonhuman primates. The cooperation between these fields is an extremely positive development providing stimulation and challenge for both fields. Studies in nonhuman primate models benefit from a testing ground for extrapolating findings and theories to the human condition. And conversely, cellular neurophysiology can provide an experimental testing ground for theories of human cognition based on patterns of areal activation under manipulated behavioral conditions. Indeed, the articles in this issue have been forthright
Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative

Purpose: As an approach to evaluate the expression pattern and status of activation of signaling pathways in clinical specimens from head and neck squamous cell carcinoma (HNSCC) patients, we established the Head and Neck Cancer Tissue Array Initiative, an international consortium aimed at developing a high-density HNSCC tissue microarray, with a high representation of oral squamous cell carcinoma. Experimental Design: These tissue arrays were constructed by acquiring cylindrical biopsies from multiple individual tumor tissues and transferring them into tissue microarray blocks. From a total of 1,300 cases, 547 cores, including controls, were selected and used to build the array. Results: Emerging information by the use of phosphospecific antibodies detecting the activated state of signaling molecules indicates that the Akt-mammalian target of rapamycin (mTOR) pathway is frequently activated in HNSCC, but independently from the activation of epidermal growth factor receptor or the detection of mutant p53. Indeed, we identified a large group of tissue samples displaying active Akt and mTOR in the absence of epidermal growth factor receptor activation. Furthermore, we have also identified a small subgroup of patients in which the mTOR pathway is activated but not Akt, suggesting the existence of an Akt-independent signaling route stimulating mTOR. Conclusions: These findings provide important information about the nature of the dysregulated signaling networks in HNSCC and may also provide the rationale for the future development of novel mechanism-based therapies for HNSCC patients.
The collective stance in modeling expertise in individuals and organizations

This paper is concerned with modeling the nature of expertise and its role in society in relation to research on expert systems and enterprise models. It argues for the adoption of a collective stance in which the human species is viewed as a single organism recursively partitioned in space and time into sub-organisms that are similar to the whole. These parts include societies, organizations, groups, individuals, roles, and neurological functions. Notions of expertise arise because the organism adapts as a whole through adaptation of its interacting parts. The phenomena of expertise correspond to those leading to distribution of tasks and functional differentiation of the parts. The mechanism is one of positive feedback from parts of the organism allocating resources for action to other parts on the basis of those latter parts past performance of similar activities. Distribution and differentiation follow if performance is rewarded, and low performers of tasks, being excluded by the feedback mechanism from opportunities for performance of those tasks, seek out alternative tasks where there is less competition. The knowledge-level phenomena of expertise, such as meaning and its representation in language and overt knowledge, arise as byproducts of the communication, coordination and modeling processes associated with the basic exchange-theoretic behavioral model. The model is linked to existing analyses of human action and knowledge in biology, psychology, sociology and philosophy, and is used to analyze the role of information technology in supporting activities in the lifeworld.
European Driver Rules in Vehicle Routing with Time Windows

As of April 2007, the European Union has new regulations concerning driver working hours. These rules force the placement of breaks and rests into vehicle routes when consecutive driving or working time exceeds certain limits. This paper proposes a large neighborhood search method for the vehicle routing problem with time windows and driver regulations. In this method, neighborhoods are explored using a column generation heuristic that relies on a tabu search algorithm for generating new columns (routes). Checking route feasibility after inserting a customer into a route in the tabu search algorithm is not an easy task. To do so, we model all feasibility rules as resource constraints, develop a label-setting algorithm to perform this check, and show how it can be used efficiently to validate multiple customer insertions into a given existing route. We test the overall solution method on modified Solomon instances and report computational results that clearly show the efficiency of our method compared to two other existing heuristics.
Interactive multiple anisotropic scattering in clouds

We propose an algorithm for the real time realistic simulation of multiple anisotropic scattering of light in a volume. Contrary to previous real-time methods we account for all kinds of light paths through the medium and preserve their anisotropic behavior. Our approach consists of estimating the energy transport from the illuminated cloud surface to the rendered cloud pixel for each separate order of multiple scattering. We represent the distribution of light paths reaching a given viewed cloud pixel with the mean and standard deviation of their entry points on the lit surface, which we call the collector area. At rendering time for each pixel we determine the collector area on the lit cloud surface for different sets of scattering orders, then we infer the associated light transport. The fast computation of the collector area and light transport is possible thanks to a preliminary analysis of multiple scattering in plane-parallel slabs and does not require slicing or marching through the volume. Rendering is done efficiently in a shader on the GPU, relying on a cloud surface mesh augmented with a Hypertexture to enrich the shape and silhouette. We demonstrate our model with the interactive rendering of detailed animated cumulus and cloudy sky at 2--10 frames per second.
Tall Tower Vertical Profiles and Diurnal Trends of Ammonia in the Colorado Front Range

Ammonia (NH3) mixing ratios were measured between the surface and 280 m aboveground level from a moveable carriage at the Boulder Atmospheric Observatory tower in summer 2014 as part of the Front Range Air Pollution and Photochemistry Éxperiment. The campaign median mixing ratio was 3.3 ppb, ranging from below detection limits to 192 ppb. Median vertical profiles show an overall increase in NH3 mixing ratios toward the surface of 6.7 ppb (89%) during the day and 3.9 ppb (141%) at night. In contrast to the overall increasing trend, some individual profiles show decreasing NH3 in the lowest 10 m. This suggests that the local surface is capable of acting as either a source or a sink, depending on the relative amounts of NH3 at the surface, and in advected air parcels. We further use this data set to investigate the variation in diurnal patterns of NH3 as a function of height above the surface. At higher altitudes (100 ± 5 and 280 ± 5 m), NH3 mixing ratios reach a gradual maximum during the day between 9:00 and 16:00 local time, likely driven by changes in source region. At lower altitudes (10 ± 5 m), the daytime maximum begins earlier at about 7:00 local time, followed by a sharper increase at 9:00 local time. At this height we also observe a peak in NH3 mixing ratios during the night, likely driven by the trapping of emitted NH3 within the shallower nocturnal boundary layer.
Three-dimensional evaluation of upper airway following rapid maxillary expansion: a CBCT study.

OBJECTIVES To evaluate, by using cone beam computed tomography, the skeletal, dental, oropharyngeal (OP) airway volume, and nasal passage (NP) volume changes that occur after rapid maxillary expansion (RME). MATERIALS AND METHODS Two groups were selected, each with 35 patients (15 males, 20 females), an RME group (mean age, 14.02 ± 1.46 years) and a control group (mean age, 14.10 ± 1.44 years). The RME group consisted of patients with maxillary constriction who were treated with Hyrax palatal expanders, and the control group comprised age- and sex-matched patients who underwent comprehensive orthodontic treatment without the use of a rapid maxillary expander. RESULTS All of the transverse skeletal (medial orbital width, lateral nasal width, maxillary width, and mandibular width) and interdental (intermolar, interpremolar, and intercanine) parameters were significantly enlarged in the RME group. A statistically significant increase in airway variables was seen in both groups between pretreatment (T0) and final records (T1). The mean increase of NP airway volume for the RME group (1719.9 ± 1510.7 mm(3)) was twofold compared with the control group (813.6 ± 1006.7 mm(3)), and no intergroup significant difference was found for the OP volume. CONCLUSIONS Rapid maxillary expansion creates a significant increase in nasal passage airway volume but no significant change in the oropharyngeal airway volume.
Neuregulins at the neuromuscular synapse: Past, present, and future

At the developing vertebrate neuromuscular junction, neuregulins are growth/differentiation factors essential for terminal Schwann cell survival. Neuregulins have also been thought as the critical signals responsible for the increased transcription of acetylcholine receptor subunit genes at the neuromuscular synapse. This latter role is now highly controversial. This article reviews the evidence that has shaped the views of the neuregulins and how these views have been challenged. The most recent experiments indicate that neuregulin signaling to postsynaptic muscle fibers may modulate, rather than determine, acetylcholine receptor expression at the neuromuscular junction. Based on findings from my lab and those of others, I propose that this modulation might involve novel posttranscriptional molecular mechanisms. Finally, I also suggest that neuregulin signaling may have an important role to play in mediating the response of adult terminal Schwann cells to denervation. © 2007 Wiley‐Liss, Inc.
Immune response after laparoscopic colectomy for cancer: a review

Background and aim: Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide and laparoscopic colectomy has been established as equivalent to the open approach in terms of oncological results and patients’ safety. Survival benefits have been reported in favor of laparoscopic colectomy (LC) in stage III CRC patients. Different immune responses after surgery, in terms of innate and cellular immunity, may potentially explain some of the reported differences. This review summarizes the literature on differences in immune response after the laparoscopic and the open approach for CRC. Materials and Methods: A literature search of electronic databases was conducted and all studies published on ‘colorectal cancer’, ‘laparoscopic and open colectomy’ ‘immune response’ and ‘surgical stress laparoscopy versus open’ were collected. Among these, the ones referring to CRC and those that had any clinical relevance offering information on perioperative parameters were used. Results: Despite the heterogeneity of studies, they support the view that innate immune response is activated to a greater degree in open colectomy (OC), which may be related to the more extensive trauma and surgical stress. On the other hand, cellular immunity is better preserved after LC. These differences are more pronounced in the immediate postoperative period. Conclusions: LC has been related to decreased up-regulation of innate immunity and better-preserved cellular immunity. The latter may be related to better anti-tumor activity and may be beneficial in terms of oncological survival in a subgroup of LC patients.
Minimally invasive surgery of the anterior skull base: transorbital approaches

Minimally invasive approaches are becoming increasingly popular to access the anterior skull base. With interdisciplinary cooperation, in particular endonasal endoscopic approaches have seen an impressive expansion of indications over the past decades. The more recently described transorbital approaches represent minimally invasive alternatives with a differing spectrum of access corridors. The purpose of the present paper is to discuss transorbital approaches to the anterior skull base in the light of the current literature. The transorbital approaches allow excellent exposure of areas that are difficult to reach like the anterior and posterior wall of the frontal sinus; working angles may be more favorable and the paranasal sinus system can be preserved while exposing the skull base. Because of their minimal morbidity and the cosmetically excellent results, the transorbital approaches represent an important addition to established endonasal endoscopic and open approaches to the anterior skull base. Their execution requires an interdisciplinary team approach.
Vision-based Markov localization across large perceptual changes

Recently, there has been significant progress towards lifelong, autonomous operation of mobile robots, especially in the field of localization and mapping. One important challenge in this context is visual localization under substantial perceptual changes, for example, coming from different seasons. In this paper, we present an approach to localize a mobile robot with a low frequency camera with respect to an image sequence, recorded previously within a different season. Our approach uses a discrete Bayes filter and a sensor model based on whole image descriptors. Thereby it exploits sequential information to model the dynamics of the system. Since we compute a probability distribution over the whole state space, our approach can handle more complex trajectories that may include same season loop-closures as well as fragmented sub-sequences. Throughout an extensive experimental evaluation on challenging datasets, we demonstrate that our approach outperforms state-of-the-art techniques.
Regulation of immune responses by I-J gene products. II. Presence of Both I-Jb and I-Jk suppressor factors in (nonsuppressor x nonsuppressor) F1 mice

Antigen-specific suppression to poly(Glu50-Tyr50) (GT) is under the control of two complementary immune suppressor (Is) genes located in the major histocompatibility (H-2) complex of the mouse. Suppressor strains of mice produce both suppressor T (Ts) cells and Ts-derived suppressor factors (TsF) that bear antigenic determinants of the I-J subregion of the H-2 complex. Nonsuppressor strains of mice, on the other hand, are not suppressed by GT preimmunization. These nonsuppressor mice, however, can be classified according to those that lack the ability to make GT-specific T cell-derived suppressor factor (GT-TsF) after GT injection (i.e., H-2a, I-Jk mice) and those that lack the ability to be suppressed by the appropriate GT-TsF (i.e., H-2b,g2, I-Jb mice). In the present study, we demonstrate that (H-2a x H- 2b,g2)F1 hybrid mice produce distinct GT-specific suppressor factors of both parental I-J haplotypes. Moreover, only the I-Jb-bearing GT-TsF derived from these F1 hybrid mice is able to induce second-order suppressor cells (Ts2). This is consistent with the observation that injection of GT-TsF1 derived from C57BL/6 (I-Jb) mice into A/J (I-Jk) mice leads to the production of an antigen-specific I-Jk GT-TsF2. Our results suggest that Is gene complementation occurs through a different cellular mechanism that was previously observed for Ir gene complementation. Further, we show that complementing (non-suppressor X nonsuppressor)F1 hybrid mice produce an I-Jb (and not an I-Jk) GT-TsF1 and an I-Jk (not an I-Jb) GT-TsF2, thus suggesting a heterogeneity of Ia loci within the I-J subregion. Data presented in the present study suggest that there may be even more heterogeneity within the I-J subregion than has has been heretofore reported with regard to I-J expression on Ts.
The relationship of Brand Commitment, Brand Credibility, Perceived Quality, Customer Satisfaction and brand loyalty: an empirical study on Stylo shoes

Group advertisement can help build brands, but dependability is what makes them preceding. If people believe they share values with an organization, they will remain loyal to the particular brand. ” There is only one boss ‘the customer’ and he can fire everybody in the company, simply investing money somewhere else, he wants. Keeping in mind that costumers are a challenging aspect for organizations, our study aims to contribute in the brand loyalty. There is a rapid increase seen in the needs of brands in the market, now a day. Customers feel good, safe, proud, sophisticated, satisfied and obliged having brands, explained by research. As customers want brands and the main purpose of this research paper was to study the contribution of brand equity, perceived quality, consumer satisfaction, brand commitment, brand credibility, and brand trust for building brand loyalty. Also, present the role of brand loyalty on brand equity. Our study also explains that how can be the customers remain loyal with a brand and what they need in it and what will be the future of all this. A self-administered questionnaire was developed to collect data from randomly selected 200 female consumers of stylo shoes in Pakistan. We constructed a structural model and tested it. The SPSS analysis was performed in order to check the fit of conceptual model presented. To evaluate the relationship between variables, correlation and regression analysis was also used. The findings of this study demonstrate that all the variables positively and significantly effects brand loyalty. Additionally, the relationship of brand loyalty and brand equity was also seen. This article and its findings have numerous limitations and give directions for future work.
Exogenous hCG activity, but not endogenous LH activity, is positively associated with live birth rates in anovulatory infertility

Objective. To evaluate, retrospectively, the roles of endogenous and exogenous luteinising hormone (LH) activity on live birth rate in ovulation induction cycles. Methods. Associations between LH activity at baseline, end of stimulation and live birth rate were analysed in relation to patient characteristics, baseline and end of stimulation variables in WHO group II anovulatory women (n = 155) stimulated with recombinant follicle-stimulating hormone (rFSH) or highly purified human menopausal gonadotrophin (HP-hMG). HP-hMG provides FSH and exogenous LH activity mainly in the form of human chorionic gonadotrophin (hCG). Results. Serum LH concentrations at baseline or end of stimulation were not predictive of live birth rate in the rFSH group (n = 79) or HP-hMG group (n = 76). Serum hCG concentration at end of stimulation was a significant positive predictor in HP-hMG-treated women. Other variables were not independently predictive of live birth in either of the groups, except for a negative association between serum FSH concentrations at the start of stimulation and live birth in the rFSH-treated group. Conclusions. Endogenous LH concentrations are not predictive of live birth in anovulatory WHO group II patients undergoing ovulation induction with rFSH or HP-hMG. On the other hand, exogenous hCG activity during HP-hMG stimulation is positively associated with treatment outcome.