Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of hydroelectric project development on the ethnobotany of the Alaknanda river basin of Western Himalaya, India

Background: This study focuses on the ethnoflora used by local communities in the Alaknanda river basin of Uttarakhand state in Western Himalaya, India. The objectives of the study were to collect ethnobotanical information, to assess the impact of hydropower projects on ethnoflora and to suggest conservation and management measures for the protection of ethnoflora. Material and Methods: A well-designed questionnaire based survey was conducted in the ten villages of the study area to collect ethnobotanical information. The conservation status of plants was also evaluated following the IUCN Red list, the Red Data Book of Indian Plants and the CITES criteria. Results: A total of 136 plant species belonging to 61 families and 112 genera were used by local communities for various ethnobotanical purposes. The majority of plant species were used for medicinal purposes (96 spp.), followed by fodder (46 spp.), wild edibles (31 spp.), fuel (29 spp.), timber (17 spp.), fish poison (9 spp.), agriculture implements (6 spp.), fibre (6 spp.), religious use (6 spp.) and handicraft (1 sp.). For the preparation of herbal medicine, rural people of the region use different parts of medicinal plants such as the whole plant (20%) followed by roots/rhizomes/tubers (20%), leaf (18%), fruit (10%), seed (9%), bark (9%), stem (6%), flowers (6%) and resin (2%). Conclusions: Development of hydropower projects will influence the diversity and distribution of ethnoflora in the region. Therefore, for the conservation of the ethnoflora of the area, conservation and management measures have been suggested.
Percentile‐based empirical distribution function estimates for performance evaluation of healthcare providers

Summary. Hierarchical models are widely used to characterize the performance of individual healthcare providers. However, little attention has been devoted to systemwide performance evaluations, the goals of which include identifying extreme (e.g. the top 10%) provider performance and developing statistical benchmarks to define high quality care. Obtaining optimal estimates of these quantities requires estimating the empirical distribution function (EDF) of provider‐specific parameters that generate the data set under consideration. However, the difficulty of obtaining uncertainty bounds for a squared error loss minimizing EDF estimate has hindered its use in systemwide performance evaluations. We therefore develop and study a percentile‐based EDF estimate for univariate provider‐specific parameters. We compute order statistics of samples drawn from the posterior distribution of provider‐specific parameters to obtain relevant assessments of uncertainty of an EDF estimate and its features, such as thresholds and percentiles. We apply our method to data from the Medicare end stage renal disease programme, which is a health insurance programme for people with irreversible kidney failure. We highlight the risk of misclassifying providers as exceptionally good or poor performers when uncertainty in statistical benchmark estimates is ignored. Given the high stakes of performance evaluations, statistical benchmarks should be accompanied by precision estimates.
Climate-Science Communication and the Measurement Problem

This paper examines the science-of-science-communication measurement problem. In its simplest form, the problem reflects the use of externally invalid measures of the dynamics that generate cultural conflict over risk and other policy-relevant facts. But at a more fundamental level, the science-of-science-communication measurement problem inheres in the phenomena being measured themselves. The “beliefs” individuals form about a societal risk such as climate change are not of a piece; rather they reflect the distinct clusters of inferences that individuals draw as they engage information for two distinct ends: to gain access to the collective knowledge furnished by science, and to enjoy the sense of identity enabled by membership in a community defined by particular cultural commitments. The paper shows how appropriately designed “science comprehension” tests — one general, and one specific to climate change — can be used to measure individuals’ reasoning proficiency as collective-knowledge acquirers independently of their reasoning proficiency as cultural-identity protectors. Doing so reveals that there is in fact little disagreement among culturally diverse citizens on what science knows about climate change. The source of the climate-change controversy and like disputes is the contamination of education and politics with forms of cultural status competition that make it impossible for diverse citizens to express their reason as both collective-knowledge acquirers and cultural-identity protectors at the same time.
A Two-Round Variant of EM for Gaussian Mixtures

We show that, given data from a mixture of k well-separated spherical Gaussians in Rn, a simple two-round variant of EM will, with high probability, learn the centers of the Gaussians to near-optimal precision, if the dimension is high (n ≫ log k). We relate this to previous theoretical and empirical work on the EM algorithm.
A Working Hypothesis for the Role of the Cerebellum in Impulsivity and Compulsivity

Growing evidence associates cerebellar abnormalities with several neuropsychiatric disorders in which compulsive symptomatology and impulsivity are part of the disease pattern. Symptomatology of autism, addiction, obsessive-compulsive (OCD), and attention deficit/hyperactivity (ADHD) disorders transcends the sphere of motor dysfunction and essentially entails integrative processes under control of prefrontal-thalamic-cerebellar loops. Patients with brain lesions affecting the cortico-striatum thalamic circuitry and the cerebellum indeed exhibit compulsive symptoms. Specifically, lesions of the posterior cerebellar vermis cause affective dysregulation and deficits in executive function. These deficits may be due to impairment of one of the main functions of the cerebellum, implementation of forward internal models of the environment. Actions that are independent of internal models may not be guided by predictive relationships or a mental representation of the goal. In this review article, we explain how this deficit might affect executive functions. Additionally, regionalized cerebellar lesions have been demonstrated to impair other brain functions such as the emergence of habits and behavioral inhibition, which are also altered in compulsive disorders. Similar to the infralimbic cortex, clinical studies and research in animal models suggest that the cerebellum is not required for learning goal-directed behaviors, but it is critical for habit formation. Despite this accumulating data, the role of the cerebellum in compulsive symptomatology and impulsivity is still a matter of discussion. Overall, findings point to a modulatory function of the cerebellum in terminating or initiating actions through regulation of the prefrontal cortices. Specifically, the cerebellum may be crucial for restraining ongoing actions when environmental conditions change by adjusting prefrontal activity in response to the new external and internal stimuli, thereby promoting flexible behavioral control. We elaborate on this explanatory framework and propose a working hypothesis for the involvement of the cerebellum in compulsive and impulsive endophenotypes.
Prolonged Cannabidiol Treatment Lacks on Detrimental Effects on Memory, Motor Performance and Anxiety in C57BL/6J Mice

The Cannabis plant contains more than 100 currently known phytocannabinoids. Regarding the rising consumption of the non-psychotropic phytocannabinoid cannabidiol (CBD) in people’s everyday life (e.g., beauty products, food and beverages), the importance of studies on the influence of CBD on healthy humans and rodents is evident. Therefore, the behavioral profile of CBD was investigated with a battery of behavioral tests, including motor, anxiety, and memory tests after prolonged CBD treatment. Adult C57Bl/6J wildtype (WT) mice were daily intraperitoneally injected with 20 mg/kg CBD for 6 weeks starting at two different points of ages (3 months and 5 months) to compare the influence of prolonged CBD treatment with a washout period (former group) to the effects of long term CBD treatment (current group). Our results show that CBD treatment does not influence motor performance on an accelerating Rotarod test, while it also results in a lower locomotor activity in the open field (OF). No influence of CBD on spatial learning and long term memory in the Morris Water Maze (MWM) was observed. Memory in the Novel Object Recognition test (NORT) was unaffected by CBD treatment. Two different anxiety tests revealed that CBD does not affect anxiety behavior in the Dark-Light Box (DLB) and OF test. Although, anxiety is altered by current CBD treatment in the Elevated Plus Maze (EPM). Moreover, CBD-treated C57Bl/6J mice showed an unaltered acoustic startle response (ASR) compared to vehicle-treated mice. However, current CBD treatment impairs prepulse inhibition (PPI), a test to analyze sensorimotor gating. Furthermore, prolonged CBD treatment did not affect the hippocampal neuron number. Our results demonstrate that prolonged CBD treatment has no negative effect on the behavior of adult C57Bl/6J mice.
PD-L1 Expression and Immune Cell Infiltration in Gastroenteropancreatic (GEP) and Non-GEP Neuroendocrine Neoplasms With High Proliferative Activity

The potential of neuroendocrine neoplasms (NEN) to respond to checkpoint inhibitors is largely unknown and full of great expectations. Immunohistochemical (IHC) studies of programmed cell death ligand 1 (PD-L1) expression in the tumor microenvironment and its implications in predicting the response to checkpoint inhibition is a very active subject. Currently, the combined analysis of PD-L1 expression and tumor-associated immune cell (TAIC) infiltration is considered the best predictive marker of therapeutic response. Here we investigated the expression of PD-L1 on tumor cells (TC) and tumor-infiltrating immune cells (IC) by IHC in 68 NEN samples with a high proliferation rate (Ki-67 >20%) from 57 patients and in 22 samples we correlated it with TAIC density by assessing intratumoral infiltration of CD3+, CD8+, and CD68+ cells. Furthermore, the tumor microenvironment was evaluated according to the classification of Teng et al. We detected PD-L1 expression in 31.6% of NEN G3. Its expression usually was weak and more IC than TC expressed PD-L1. The proportion of tumors positive for PD-L1 was comparable in NEN from different sites of origin but varied depending on tumor differentiation and disease extension. No positive IHC staining was found in 3 well-differentiated neuroendocrine tumors (NETs) with a proliferation rate above 20% (NET G3). When analyzing TAIC, we rarely (18.2%) detected intratumoral CD8+ cells, whereas infiltration by CD3+ and CD68+ cells was more common (45.5 and 59.1%, respectively). By combining CD3+ cells and PD-L1 status, we identified the immune ignorant phenotype of tumor microenvironment as being the most common phenotype, supporting the concept of a preferably combined immunotherapeutic approach in neuroendocrine carcinoma (NEC).
The happiness–income paradox revisited

The striking thing about the happiness–income paradox is that over the long-term —usually a period of 10 y or more—happiness does not increase as a country's income rises. Heretofore the evidence for this was limited to developed countries. This article presents evidence that the long term nil relationship between happiness and income holds also for a number of developing countries, the eastern European countries transitioning from socialism to capitalism, and an even wider sample of developed countries than previously studied. It also finds that in the short-term in all three groups of countries, happiness and income go together, i.e., happiness tends to fall in economic contractions and rise in expansions. Recent critiques of the paradox, claiming the time series relationship between happiness and income is positive, are the result either of a statistical artifact or a confusion of the short-term relationship with the long-term one.
Plural Conjuncts and Syncretism Facilitate Gender Agreement in Serbo-Croatian:Experimental Evidence

The literature on agreement in South Slavic generalizes that conjunct agreement in gender is only possible when all conjuncts are plural (e.g., Bošković, 2009). Marušič et al. (2015) and Arsenijević and Mitić (2016a,b) attest a significant level of patterns contradicting this claim in elicited production experiments. They weaken the earlier generalization to a facilitating role of plural number for conjunct agreement in gender. However, the stimuli in the two respective experiments involve syncretism between the members of conjunction. The syncretism removes the possibility – at Phonological Form at least – that by agreeing with one conjunct, the verb disagrees with the other. It is hence expected to result in a similar surface effect as the facilitation by plurals, which makes it a potential confound variable. We report and discuss the results of an experiment aimed to test both the effect of syncretism and the reality of the facilitating effects of plural number. The results of the experiment yield positive answers to both questions: syncretism is a facilitating factor, but plural number nevertheless has its facilitating effect too – as confirmed by the stimuli without syncretism. Since syncretism is a phenomenon in which phonological information plays a central role, our findings support syntactic models of agreement which extend to the interface with phonology. Moreover, our results reveal a double similarity of conjunct agreement with agreement attraction, in both showing a (stronger) attraction effect of plural number compared to singular, and in being sensitive to syncretism (cf. Badecker and Kuminiak, 2007; Malko and Slioussar, 2013; i.e., Bader and Meng, 2002; Hartsuiker et al., 2003; Slioussar, 2018).
Structural Factors and Policy Change as Related to the Quality of Early Childhood Education and Care for 3–4 Year Olds in the UK

In many developed countries it is now the norm for preschool children to spend time outside the home in early childhood education and care (ECEC). Research indicates that attending ECEC can promote longer-term positive life outcomes, which is more likely when the ECEC is of higher quality. In a UK Study of 600 ECEC group settings for 3-4 year olds, staff qualifications were predictive of quality at private (for profit) settings. For voluntary (not for profit) settings, which were more homogenous in staff qualifications, having a staff training plan and a better staff to child ratio were found to be significant predictors of quality. However, state funded nursery classes / schools, which tend to have less favourable staff to child ratios than private and voluntary settings, also tended to have higher process quality ratings, where the presence of more highly qualified staff apparently allowed quality to be maintained with a larger number of children per staff member. A comparison of equivalent quality data from separate UK studies, conducted before and after a period of substantial policy change in relation to ECEC quality, indicated that policy change may have powerful effects in improving ECEC quality with implications for long-term child, and potentially adult, well-being.
Artificial Structural Color Pixels: A Review

Inspired by natural photonic structures (Morpho butterfly, for instance), researchers have demonstrated varying artificial color display devices using different designs. Photonic-crystal/plasmonic color filters have drawn increasing attention most recently. In this review article, we show the developing trend of artificial structural color pixels from photonic crystals to plasmonic nanostructures. Such devices normally utilize the distinctive optical features of photonic/plasmon resonance, resulting in high compatibility with current display and imaging technologies. Moreover, dynamical color filtering devices are highly desirable because tunable optical components are critical for developing new optical platforms which can be integrated or combined with other existing imaging and display techniques. Thus, extensive promising potential applications have been triggered and enabled including more abundant functionalities in integrated optics and nanophotonics.
Higher Protein Density Diets Are Associated With Greater Diet Quality and Micronutrient Intake in Healthy Young Adults

Objective: This study characterized habitual dietary protein intake in healthy young adults entering military service and explored whether diet protein density is associated with diet quality and micronutrient intake. Methods: An FFQ was used to estimate habitual dietary intake and calculate HEI scores in 276 males [mean(SD), age:21.1y(3.8)] and 254 females [age:21.2y(3.7)]. Multivariate-adjusted MANCOVA and ANCOVA models were used to identify associations between protein density quartiles and HEI scores and micronutrient intake. Higher HEI components scores for sodium, refined grains, and empty calories indicate lower intake; higher scores for all other components indicate higher intakes. Results: Mean(SD) energy-adjusted protein intakes were 29.3(3.2), 36.0(1.4), 40.8(1.3), and 47.9(3.9) g/1,000 kcal for protein density quartiles 1–4, respectively. For males, empty calorie scores as well as dark green and orange vegetable scores were higher in quartiles 3 and 4 than 1 and 2 (all, p < 0.05). Scores for total vegetable, dairy, and total protein foods were lower in quartile 1 vs. quartiles 2, 3, and 4 (all, p < 0.05). Sodium scores decreased as quartiles increased (p < 0.001). Total HEI, fruit, whole grains, seafood and plant protein, fatty acids, and refined grain scores did not differ. For females, total HEI, vegetable, and total protein foods scores were higher in quartiles 3 and 4 than 1 and 2 (all, p < 0.05). Empty calorie scores increased as quartile increased (p < 0.05). Dairy scores were higher in quartiles 2, 3, and 4 than 1 (p < 0.05). Whole fruit scores were lowest in quartile 1 (p < 0.05). Whole grain as well as seafood and plant protein scores were higher in quartile 4 vs. 1 (both, p < 0.05). Sodium scores decreased as quartile increased (p < 0.001). Fatty acids scores did not differ. For males and females, micronutrient intakes progressively increased across quartiles with the exception of calcium and vitamin C, (all, p < 0.05). Intakes remained nearly the same when controlled for fruit and vegetable intake. Conclusion: These cross-sectional data suggest that habitually consuming a higher protein density diet is associated with better scores for some, but not all, diet quality components in males, better overall diet quality scores in females, and greater intakes of micronutrients in both male and female healthy, young adults entering military service.
Point-and-Shoot Memories

Two studies examined whether photographing objects impacts what is remembered about them. Participants were led on a guided tour of an art museum and were directed to observe some objects and to photograph others. Results showed a photo-taking-impairment effect: If participants took a photo of each object as a whole, they remembered fewer objects and remembered fewer details about the objects and the objects’ locations in the museum than if they instead only observed the objects and did not photograph them. However, when participants zoomed in to photograph a specific part of the object, their subsequent recognition and detail memory was not impaired, and, in fact, memory for features that were not zoomed in on was just as strong as memory for features that were zoomed in on. This finding highlights key differences between people’s memory and the camera’s “memory” and suggests that the additional attentional and cognitive processes engaged by this focused activity can eliminate the photo-taking-impairment effect.
Rhizobium etli Produces Nitrous Oxide by Coupling the Assimilatory and Denitrification Pathways

More than two-thirds of the powerful greenhouse gas nitrous oxide (N2O) emissions from soils can be attributed to microbial denitrification and nitrification processes. Bacterial denitrification reactions are catalyzed by the periplasmic (Nap) or membrane-bound (Nar) nitrate reductases, nitrite reductases (NirK/cd1Nir), nitric oxide reductases (cNor, qNor/ CuANor), and nitrous oxide reductase (Nos) encoded by nap/nar, nir, nor and nos genes, respectively. Rhizobium etli CFN42, the microsymbiont of common bean, is unable to respire nitrate under anoxic conditions and to perform a complete denitrification pathway. This bacterium lacks the nap, nar and nos genes but contains genes encoding NirK and cNor. In this work, we demonstrated that R. etli is able to grow with nitrate as the sole nitrogen source under aerobic and microoxic conditions. Genetic and functional characterization of a gene located in the R. etli chromosome and annotated as narB demonstrated that growth under aerobic or microoxic conditions with nitrate as nitrogen source as well as nitrate reductase activity requires NarB. In addition to be involved in nitrate assimilation, NarB is also required for NO and N2O production by NirK and cNor, respectively, in cells grown microoxically with nitrate as the only N source. Furthermore, β-glucuronidase activity from nirK::uidA and norC::uidA fusions, as well as NorC expression and Nir and Nor activities revealed that expression of nor genes under microoxic conditions also depends on nitrate reduction by NarB. Our results suggest that nitrite produced by NarB from assimilatory nitrate reduction is detoxified by NirK and cNor denitrifying enzymes that convert nitrite into NO which in turn is reduced to N2O, respectively.
Live to Work or Work to Live? An Age-Moderated Mediation Model on the Simultaneous Mechanisms Prompted by Workaholism Among Healthcare Professionals

The “aging population” implies an increased proportion of older professionals and a growing demand for healthcare services. Healthcare professionals are often highly committed to their work which can be reflected in high levels of workaholism, being a double-edged sword that can prompt both positive and negative mechanisms, differently affecting younger and older healthcare workers. The present study aims to gain insights into the relationships between healthcare professionals' age, workaholism and job satisfaction, by estimating the sequential mediating roles of workload perceptions and emotional exhaustion. We used original survey data, including information on 750 healthcare professionals. Overall, the negative relationship between workaholism and job satisfaction was shown to be sequentially (and partially) mediated by workload perceptions and emotional exhaustion. Multi-Group SEM analyses revealed differences across three age groups (under 35; between 35 and 50; over 50). Only in the two younger age groups, we found a direct and positive relationship between workaholism and job satisfaction. In all age groups, we found the negative relationship between workaholism and job satisfaction to be sequentially (and partially) mediated by workload perceptions and emotional exhaustion. The indirect effects were relatively stronger in the younger age group. Workaholism can prompt both a “gain spiral” and “a loss spiral” among healthcare professionals. The first reflects workaholism to function as a job resource fostering job satisfaction (only for the two younger age groups). The second reflects workaholism to function as a job demand reducing job satisfaction. This mechanism was shown to be stronger with an increasing age.