Miracle-dz/UniFAR-FTUs huggingface dataset:
Localized pointwise error estimates for mixed finite element methods

In this paper we give weighted, or localized, pointwise error estimates which are valid for two different mixed finite element methods for a general second-order linear elliptic problem and for general choices of mixed elements for simplicial meshes. These estimates, similar in spirit to those recently proved by Schatz for the basic Galerkin finite element method for elliptic problems, show that the dependence of the pointwise errors in both the scalar and vector variables on the derivative of the solution is mostly local in character, or conversely that the global dependence of the pointwise errors is weak. This localization is more pronounced for higher order elements. Our estimates indicate that localization occurs except when the lowest order Brezzi-DouglasMarini elements are used, and we provide computational examples showing that the error is indeed not localized when these elements are employed.
Maize Profilin Isoforms Are Functionally Distinct

Profilin is an actin monomer binding protein that, depending on the conditions, causes either polymerization or depolymerization of actin filaments. In plants, profilins are encoded by multigene families. In this study, an analysis of native and recombinant proteins from maize demonstrates the existence of two classes of functionally distinct profilin isoforms. Class II profilins, including native endosperm profilin and a new recombinant protein, ZmPRO5, have biochemical properties that differ from those of class I profilins. Class II profilins had higher affinity for poly-L-proline and sequestered more monomeric actin than did class I profilins. Conversely, a class I profilin inhibited hydrolysis of membrane phosphatidylinositol-4,5-bisphosphate by phospholipase C more strongly than did a class II profilin. These biochemical properties correlated with the ability of class II profilins to disrupt actin cytoplasmic architecture in live cells more rapidly than did class I profilins. The actin-sequestering activity of both maize profilin classes was found to be dependent on the concentration of free calcium. We propose a model in which profilin alters cellular concentrations of actin polymers in response to fluctuations in cytosolic calcium concentration. These results provide strong evidence that the maize profilin gene family consists of at least two classes, with distinct biochemical and live-cell properties, implying that the maize profilin isoforms perform distinct functions in the plant.
IMLEMENTASI SIMULASI PhET DAN KIT SEDERHANA UNTUK MENGAJARKAN KETERAMPILAN PSIKOMOTOR SISWA PADA POKOK BAHASAN ALAT OPTIK

Penelitian ini bertujuan untuk menuntaskan hasil belajar psikomotor fisika siswa dengan penerapan simulasi PhET dan KIT sederhana pada siswa. Hasil penelitian menunjukkan bahwa keterlaksanaan pembelajaran berjalan dengan baik sesuai dengan RPP, hasil psikomotor kelas eksperimen 1 dengan menggunakan simulasi PhET dan kelas eksperimen 2 dengan menggunakan KIT sederhana dapat menuntaskan hasil belajar siswa, serta respon siswa terhadap pembelajaran positif. Berdasarkan hasil temuan di atas dapat disimpulkan bahwa implementasi simulasi PhET dan KIT sederhana untuk mengajarkan keterampilan psikomotor siswa pada pokok bahasan alat optik dapat menuntaskan hasil belajar psimotor siswa. This study aims to resolve learning outcomes physics psychomotor of students with the application of PhET simulations and simple KIT on students. The results showed that implementation of learning going well according to the lesson plan, student who are in the experimental class 1 using PhET simulation and the experimental class 2 using a simple KIT could complete the learning outcomes, and student respond to learning was positive. According to the finding above it could be conclude that the implementation PhET simulation and simple KIT to teach psychomotor skills of students on the subject of optical can to complete psychomotor learning outcomes of students.
MEMS Sensor Technologies for Human Centred Applications in Healthcare, Physical Activities, Safety and Environmental Sensing: A Review on Research Activities in Italy

Over the past few decades the increased level of public awareness concerning healthcare, physical activities, safety and environmental sensing has created an emerging need for smart sensor technologies and monitoring devices able to sense, classify, and provide feedbacks to users’ health status and physical activities, as well as to evaluate environmental and safety conditions in a pervasive, accurate and reliable fashion. Monitoring and precisely quantifying users’ physical activity with inertial measurement unit-based devices, for instance, has also proven to be important in health management of patients affected by chronic diseases, e.g., Parkinson’s disease, many of which are becoming highly prevalent in Italy and in the Western world. This review paper will focus on MEMS sensor technologies developed in Italy in the last three years describing research achievements for healthcare and physical activity, safety and environmental sensing, in addition to smart systems integration. Innovative and smart integrated solutions for sensing devices, pursued and implemented in Italian research centres, will be highlighted, together with specific applications of such technologies. Finally, the paper will depict the future perspective of sensor technologies and corresponding exploitation opportunities, again with a specific focus on Italy.
[Renal involvement in the human immunodeficiency virus infection].

BACKGROUND AND OBJECTIVE Although renal pathologies are becoming an emergent problem in the population infected by the human immunodeficiency virus (HIV), there is very scarce information about the natural course of this problem. The objective of the present study is to describe renal lesions in an autopsy series of HIV-infected patients never treated with antiretroviral therapies. PATIENTS AND METHOD Autopsy information has been retrospectively retrieved from 61 HIV-infected subjects (mean age, 36,9 [8,4] years; 58,6% drug abusers, 84% males) died in our hospital between 1984 and 1997. None of the patients received antiretroviral therapy. All autopsy and clinical reports were considered, as well as basic analytical parameters about renal function. Renal autopsy samples were specifically reviewed. RESULTS At the time of the last admission, 9.8% of patients had renal insufficiency, who made up 44.3% of patients having renal insufficiency anytime. Infections were the main cause of death (76%). The majority of patients (93.4%) showed histopathological renal abnormalities, which were highly heterogeneous. Renal lesions were mainly located on the tubules (96.7%) and the interstitium (60.7%). Moreover, glomeruli were affected in 55.7% of patients. Most frequent histopathological diagnosis was acute tubular necrosis (16.4%) and septic nephritic abscesses (16.4%), followed by tubulointerstitial nephritis (9%). HIV-associated nephropathy was present in two patients (3.3%). There were no significant differences when considering the existent of renal failure. CONCLUSIONS Renal histological abnormalities are frequent in the natural evolution of HIV infection. There is an important heterogeneity of lesions, mainly involving tubules, interstitium and mesangium. The cause of renal lesions is predominantly septic, according to the chief systemic process. It does not exist any relationship between renal analytical parameters and the presence of renal damage.
Characteristics of Squamous Cell Carcinoma In Situ of the Ear Treated Using Mohs Micrographic Surgery

BACKGROUND Mohs micrographic surgery (MMS) is used to treat squamous cell carcinoma in situ (SCCIS) for tissue conservation. OBJECTIVE To examine characteristics of patients with SCCIS of the external ear treated using MMS. METHODS A retrospective review from 2005 to 2011. RESULTS We identified 173 cases of SCCIS of the ear. The population was 94% male (p < .01), with a mean age of 71. Eight percent (n = 13) of tumors were recurrent after prior treatment. Recurrent tumors occurred exclusively in men and were associated with larger initial size (p = .05), more layers for clearance p = . 059), and larger final defect size (p = .01). Tumors with larger initial area were independently associated with older age (p < .01). Complexity of repair was independently associated with more layers (p < .01), larger initial area (p = .01), and larger final area (p = .02). Sex did not affect repair type. CONCLUSION SCCIS of the ear predominantly affects men in our referral base of 85% to 90% private patients and 10% to 15% veterans. Recurrent tumors were associated with larger initial size and subclinical spread of tumor. Primary tumors on average required 1.6 layers, validating the utility of MMS in this population in delineating the subclinical spread of SCCIS of the ear.
Learning outcomes and program-level evaluation in a four-year undergraduate pharmacy curriculum.

OBJECTIVE To determine the successful implementation and effectiveness of program-level learning outcomes for a 4-year bachelor of science pharmacy degree program. METHODS A comprehensive and iterative program evaluation framework was implemented and quantitative and qualitative data were gathered. RESULTS The critical factors in the successful development and implementation of program-level learning outcomes in this context were program accreditation, the leadership qualities of the curriculum chair, a strong and adequately resourced curriculum team that was able to engage and mobilize the faculty learning community, and scholarly approaches to curriculum reform. CONCLUSION An integrated range of institutional and programmatic strategies enhance the implementation of program-level learning outcomes in a 4-year undergraduate curriculum.
Primary antifungal prophylaxis with micafungin in patients with haematological malignancies: real‐life data from a retrospective single‐centre observational study

Mould‐active antifungal prophylaxis is increasingly used in patients at risk for invasive fungal disease. Between June 2011 and June 2012, one hundred patients with various haematological malignancies at risk for invasive fungal disease received primary antifungal prophylaxis with intravenous micafungin at a daily dosage of 50 mg during neutropenia. The median number of days on micafungin prophylaxis was 14 (range, 6–48 d). The incidence of proven and probable breakthrough invasive fungal diseases (bIFDs) was 6% and 3%, respectively. There were two bloodstream infections caused by yeasts or yeast‐like fungi (Candida krusei, Trichosporon asahii) in two patients during the neutropenic phase after allogeneic haematopoietic stem cell transplantation. Four proven bIFDs caused by non‐Aspergillus moulds and three cases of probable pulmonary bIFDs were documented during the neutropenic phase after induction/consolidation chemotherapy for acute leukaemia. Colonisation with Candida spp. was documented in 51% of the patients with none of the isolates being in vitro micafungin resistant. Compared to a historical control, receiving primary prophylaxis with posaconazole micafungin is at least as effective in preventing IFD. In both cohorts, bIFDs were exclusively caused by emerging pathogens with a highly preserved in vitro sensitivity to amphotericin B.
Optimization-based strategy in multiple-channel magnetic resonance systems operating at 128 MHz to reduce radiofrequency heating induced by active implantable medical devices

This paper presents a strategy, based on optimization techniques, to design the radiofrequency excitations in a multiple-channel magnetic resonance system operating at 128 MHz, in order to enhance radiofrequency magnetic field 1 homogeneity while reducing the estimated mean induced power deposited (Pind) by an active implantable medical device. Numerical examples on an implanted patient with a generic implant in different locations of a deep brain stimulator undergoing head/brain imaging are presented. Results from these examples show that more degrees of freedom (number of channels) can provide reduced induced deposited power while maintaining a high homogeneity.
Work in the Spirit: Toward a Theology of Work

Work in the limelight Meaning of work Economic framework Contemporary World of Work: The Problem of Work: Importance of work Transformation of work Crisis of work Toward a Theology of Work: Theology of work On crafting a theology of work Theology of work and new creation Work, Spirit, and New Creation: Work and new creation Spirit, work, and environment Spirit, work, and human needs Spirit, work, and unemployment Alienation and Humanization of Work: Character of alienation Reasons for concern.
Right Supramarginal Gyrus Is Crucial to Overcome Emotional Egocentricity Bias in Social Judgments

Humans tend to use the self as a reference point to perceive the world and gain information about other people's mental states. However, applying such a self-referential projection mechanism in situations where it is inappropriate can result in egocentrically biased judgments. To assess egocentricity bias in the emotional domain (EEB), we developed a novel visuo-tactile paradigm assessing the degree to which empathic judgments are biased by one's own emotions if they are incongruent to those of the person we empathize with. A first behavioral experiment confirmed the existence of such EEB, and two independent fMRI experiments revealed that overcoming biased empathic judgments is associated with increased activation in the right supramarginal gyrus (rSMG), in a location distinct from activations in right temporoparietal junction reported in previous social cognition studies. Using temporary disruption of rSMG with repetitive transcranial magnetic stimulation resulted in a substantial increase of EEB, and so did reducing visuo-tactile stimulation time as shown in an additional behavioral experiment. Our findings provide converging evidence from multiple methods and experiments that rSMG is crucial for overcoming emotional egocentricity. Effective connectivity analyses suggest that this may be achieved by early perceptual regulation processes disambiguating proprioceptive first-person information (touch) from exteroceptive third-person information (vision) during incongruency between self- and other-related affective states. Our study extends previous models of social cognition. It shows that although shared neural networks may underlie emotional understanding in some situations, an additional mechanism subserved by rSMG is needed to avoid biased social judgments in other situations.
Chamaerops humilis L. var. argentea André date palm seed oil: a potential dietetic plant product.

Chamaerops humilis L. var. argentea André (C. humilis) date palm seeds are an underutilized source of vegetable oil, and no studies describing their physicochemical characteristics to indicate the potential uses of this seed or seed oil have been reported. The oil content of the seeds is about 10%, mainly composed of oleic acid (38.71%), lauric acid (21.27%), linoleic acid (15.15%), palmitic acid (9.96%), and stearic acid (7.17%). The tocol (tocopherols and tocotrienols) content is 74 mg/100 g, with δ-tocotrienol as the major contributor (31.91%), followed by α-tocotrienol (29.37%), γ-tocopherol (20.16%), and γ-tocotrienol (11.86%). Furthermore, this oil shows high thermal stability. The differential scanning calorimetery curves revealed that the melting and crystallization points are 9.33 °C and -15.23 °C, respectively.
Anxiety in schools : the causes, consequences, and solutions for academic anxieties

Contents: Jerrell C. Cassady: Test Anxiety: Contemporary Theories and Implications for Learning - Mark Brosnan/Peter Goodison: Anxiety, Flow, and Boredom: Optimizing Computer-Based Learning in the Classroom - Molly M. Jameson: Math Anxiety: Theoretical Perspectives on Potential Influences and Outcomes - S. Michael Putman: The Debilitative Effects of Anxiety on Reading Affect - Shari L. Britner: Science Anxiety: Relationship to Achievement, Self-Efficacy, and Pedagogical Factors - Elaine K. Horwitz/Michael Tallon/Han Luo: Foreign Language Anxiety - Jason W. Osborne/David Tillman/Abigail Holland: Stereotype Threat and Anxiety for Disadvantaged Minorities and Women - Rebecca S. Martinez/Thomas J. Huberty: Anxiety in Students with Learning Difficulties and Learning Disabilities - Sal Mendaglio: Anxiety in Gifted Students - Kathryn L. Fletcher/Jerrell C. Cassady: Overcoming Academic Anxieties: Promoting Effective Coping and Self-Regulation Strategies.
Gaze Stripes: Image-Based Visualization of Eye Tracking Data

We present a new visualization approach for displaying eye tracking data from multiple participants. We aim to show the spatio-temporal data of the gaze points in the context of the underlying image or video stimulus without occlusion. Our technique, denoted as gaze stripes, does not require the explicit definition of areas of interest but directly uses the image data around the gaze points, similar to thumbnails for images. A gaze stripe consists of a sequence of such gaze point images, oriented along a horizontal timeline. By displaying multiple aligned gaze stripes, it is possible to analyze and compare the viewing behavior of the participants over time. Since the analysis is carried out directly on the image data, expensive post-processing or manual annotation are not required. Therefore, not only patterns and outliers in the participants' scanpaths can be detected, but the context of the stimulus is available as well. Furthermore, our approach is especially well suited for dynamic stimuli due to the non-aggregated temporal mapping. Complementary views, i.e., markers, notes, screenshots, histograms, and results from automatic clustering, can be added to the visualization to display analysis results. We illustrate the usefulness of our technique on static and dynamic stimuli. Furthermore, we discuss the limitations and scalability of our approach in comparison to established visualization techniques.
Renin, angiotensinogen, and kallikrein gene expression in two-kidney Goldblatt hypertensive rats.

An imbalance in the activity of the vasopressor renin-angiotensin and vasodepressor kallikrein-kinin systems may play an important role in the pathogenesis of hypertension after unilateral renal artery constriction. To test this hypothesis, we examined the expression of the renin, angiotensinogen (Ao), and tissue kallikrein genes 7 and 25 days after placement of a 0.25-mm clip on the left renal artery of rats. One week after clipping, renin mRNA levels were 4.6-fold higher in the clipped and 50% lower in the nonclipped kidneys compared with kidneys from sham-operated rats. At 25 days, renin mRNA levels in the clipped kidneys were not different from sham kidneys, but were suppressed to almost undetectable levels in the nonclipped kidneys. Steady-state Ao mRNA levels in the clipped kidneys were not different from those of nonclipped or sham kidneys at either 7 or 25 days. However, at 25 days, Ao mRNA levels were lower in the liver (70%), left ventricle (55%), and aorta (45%) of clipped than sham-operated rats. The expression of the renal kallikrein gene was unchanged at 7 days and was suppressed by 50% at 25 days. These results are consistent with the notion that activation of the intrarenal renin-angiotensin system occurs during the initial phase of the two-kidney, one-clip hypertension model. The renal kallikrein gene, in marked contrast to renin, becomes downregulated in the chronic phase. The differential regulation of renin-angiotensin and kallikrein genes may be an important pathogenetic factor in renovascular hypertension. (ABSTRACT TRUNCATED AT 250 WORDS)
Campylobacter Enteritis in South Australia

Campylobacter jejuni was isolated on copro–culture from 13 of 224 patients with suspected infectious diarrhoea whose faecal specimens were examined during a three–month period. These organisms were not isolated from 530 specimens received from asymptomatic and healthy individuals. Diarrhoea and cramping abdominal pain generally lasting two to three days were the major symptoms, though occasional patients had a more prolonged illness. Ingestion of Campylobacter resulted in enteric infection with increasing numbers of Campylobacter in the stool. Clinical laboratories should attempt to isolate these organisms from patients with diarrhoea.
Prediction of P-Glycoprotein Substrates by a Support Vector Machine Approach

P-glycoproteins (P-gp) actively transport a wide variety of chemicals out of cells and function as drug efflux pumps that mediate multidrug resistance and limit the efficacy of many drugs. Methods for facilitating early elimination of potential P-gp substrates are useful for facilitating new drug discovery. A computational ensemble pharmacophore model has recently been used for the prediction of P-gp substrates with a promising accuracy of 63%. It is desirable to extend the prediction range beyond compounds covered by the known pharmacophore models. For such a purpose, a machine learning method, support vector machine (SVM), was explored for the prediction of P-gp substrates. A set of 201 chemical compounds, including 116 substrates and 85 nonsubstrates of P-gp, was used to train and test a SVM classification system. This SVM system gave a prediction accuracy of at least 81.2% for P-gp substrates based on two different evaluation methods, which is substantially improved against that obtained from the multiple-pharmacophore model. The prediction accuracy for nonsubstrates of P-gp is 79.2% using 5-fold cross-validation. These accuracies are slightly better than those obtained from other statistical classification methods, including k-nearest neighbor (k-NN), probabilistic neural networks (PNN), and C4.5 decision tree, that use the same sets of data and molecular descriptors. Our study indicates the potential of SVM in facilitating the prediction of P-gp substrates.
Multifrequency Microwave Emission from Forests

Retrieving information on forest biomass and soil under vegetation is crucial for all studies concerning global changes and carbon balance. The capability of microwaves in penetrating vegetation covers is well known, but only few studies have investigated emission from soil under forests and the contribution of single tree elements to total radiation. To further examine quantitatively these aspects a study has been carried out by using ground based multifrequency radiometric observations and model analysis. The results of this study made it possible to evaluate the contribution of the tree components to total emission and their effects on soil moisture measurement.
Time Space Translation: A Hox Mechanism for Vertebrate A-P Patterning

The vertebrate A-P axis is a time axis. The head is made first and more and more posterior levels are made at later and later stages. This is different to the situation in most other animals, for example, in Drosophila. Central to this timing is Hox temporal collinearity (see below). This occurs rarely in the animal kingdom but is characteristic of vertebrates and is used to generate the primary axial Hox pattern using time space translation and to integrate successive derived patterns (see below). This is thus a different situation than in Drosophila, where the primary pattern guiding Hox spatial collinearity is generated externally, by the gap and segmentation genes.