Miracle-dz/UniFAR-FTUs huggingface dataset:
OptionGAN: Learning Joint Reward-Policy Options using Generative Adversarial Inverse Reinforcement Learning

Reinforcement learning has shown promise in learning policies that can solve complex problems. However, manually specifying a good reward function can be difficult, especially for intricate tasks. Inverse reinforcement learning offers a useful paradigm to learn the underlying reward function directly from expert demonstrations. Yet in reality, the corpus of demonstrations may contain trajectories arising from a diverse set of underlying reward functions rather than a single one. Thus, in inverse reinforcement learning, it is useful to consider such a decomposition. The options framework in reinforcement learning is specifically designed to decompose policies in a similar light. We therefore extend the options framework and propose a method to simultaneously recover reward options in addition to policy options. We leverage adversarial methods to learn joint reward-policy options using only observed expert states. We show that this approach works well in both simple and complex continuous control tasks and shows significant performance increases in one-shot transfer learning.
Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population.

BACKGROUND Work from our laboratory has proven that increased titers of anti-heat shock protein 60 (HSP60) antibodies are associated with atherosclerosis and that HSP60-reactive T-cells are present in atherosclerotic lesions. Recent studies from others demonstrated that HSP60 directly activates endothelial cells and macrophages. METHODS AND RESULTS To explore the possibility that HSP60 exists in the circulation, where it could exert its functions, we performed a population-based study with 826 subjects aged 40 to 79 years. The following items were measured in all participants: serum soluble HSP60 (sHSP60); anti-Escherichia coli lipopolysaccharide; anti-HSP65, anti-Chlamydia and anti-Helicobacter pylori antibodies; and a variety of acute phase reactants (C-reactive protein, alpha(1)-antitrypsin, and ceruloplasmin) and markers of systemic inflammation. Carotid atherosclerosis was assessed twice (1990 and 1995), and 15 other risk factors were evaluated. Our data show that levels of sHSP60 were significantly elevated in subjects with prevalent/incident carotid atherosclerosis and that these levels were correlated with common carotid artery intima/media thickness. Multiple logistic regression analysis documented these associations as independent of age, sex, and other risk factors. Interestingly, sHSP60 was also correlated with anti-lipopolysaccharide, anti-Chlamydia and anti-HSP60 antibodies, various markers of inflammation, and the presence of chronic infections. The risk of atherosclerosis associated with high sHSP60 levels was amplified when subjects had clinical and/or laboratory evidence of chronic infections. CONCLUSIONS Our data provide the first evidence of a strong correlation between sHSP60 and atherosclerosis, suggesting that sHSP60 may play important roles in activating vascular cells and the immune system during the development of atherosclerosis.
Intellectual Development and the Organization of Knowledge.

L'etude de l'organisation du savoir autant que la formation aux techniques de bibliotheconomie et de traitement de l'information a des consequences sur le developpement intellectuel des etudiants. L'auteur envisage l'amelioration de l'enseignement dispense dans les ecoles de bibliothecaires a partir des recherches menees dans les domaines de l'education, de l'organisation sociale et de la logique
Synchronization with audio and visual stimuli: Exploring multisensory integration and the role of spatio-temporal information

Information lies at the very heart of the interaction between an individual and their environment, which has led many researchers to argue that the coupling constraining rhythmic coordination is informational. In an attempt to address this informational basis for perception-action this thesis explored the specific information from a given environmental stimulus that is used to control our actions. Namely, participants in the three studies synchronized wrist-pendulum movements with auditory and visual stimuli with different spatio-temporal structures. The aim of this thesis was to establish the role of spatial and temporal information in the control of rhythmic actions. Study 1 revealed that the presence of spatial information significantly improved synchronization with a continuous visual stimulus. Interestingly, the absence of spatial information still produced good levels of coordination indicating a resilience of motor coordination to adapt to changes in the environment. Study 2 expanded on these findings using an auditory stimulus, revealing that the supplementation of spatial information did not have a significant impact on synchronization with this modality. When these auditory and visual stimuli were combined in bimodal conditions there appeared to be no benefit over the unimodal conditions and instead there was a strong bias towards the visual stimuli in these multisensory conditions. The first experiment from Study 3 specifically addressed the role of perceiving relative direction for visual and auditory stimuli by partially occluding these stimuli. While perceiving relative direction at the endpoints of a stimulus’ trajectory was important for both modalities, the auditory modality relied more heavily on this information. The second experiment revealed that when information is occluded in one modality another modality can effectively “fill-in” for the missing information and help to stabilise coordination. The results from the three studies in this thesis clearly indicate that spatial information plays a different role in synchronizing with visual compared to auditory stimuli. These differences are more than likely related to the fact that spatial information is more easily perceived with visual compared to auditory stimuli. Additionally, comparing the bimodal results from study 2 and 3 appears to indicate that the integration of sensory information for improving motor coordination may be mediated by task difficulty. Future research may look to address the specific role that task difficulty plays in multisensory integration.
Interlingual Annotation of Multilingual Text Corpora

This paper describes a multi-site project to annotate six sizable bilingual parallel corpora for interlingual content. After presenting the background and objectives of the effort, we will go on to describe the data set that is being annotated, the interlingua representation language used, an interface environment that supports the annotation task and the annotation process itself. We will then present a preliminary version of our evaluation methodology and conclude with a summary of the current status of the project along with a number of issues which have arisen.
Proposition of a Theoretical Model for Missing Data Imputation using Deep Learning and Evolutionary Algorithms

In the last couple of decades, there has been major advancements in the domain of missing data imputation. The techniques in the domain include amongst others: Expectation Maximization, Neural Networks with Evolutionary Algorithms or optimization techniques and K-Nearest Neighbor approaches to solve the problem. The presence of missing data entries in databases render the tasks of decision-making and data analysis nontrivial. As a result this area has attracted a lot of research interest with the aim being to yield accurate and time efficient and sensitive missing data imputation techniques especially when time sensitive applications are concerned like power plants and winding processes. In this article, considering arbitrary and monotone missing data patterns, we hypothesize that the use of deep neural networks built using autoencoders and denoising autoencoders in conjunction with genetic algorithms, swarm intelligence and maximum likelihood estimator methods as novel data imputation techniques will lead to better imputed values than existing techniques. Also considered are the missing at random, missing completely at random and missing not at random missing data mechanisms. We also intend to use fuzzy logic in tandem with deep neural networks to perform the missing data imputation tasks, as well as different building blocks for the deep neural networks like Stacked Restricted Boltzmann Machines and Deep Belief Networks to test our hypothesis. The motivation behind this article is the need for missing data imputation techniques that lead to better imputed values than existing methods with higher accuracies and lower errors.
A New Approximation for Effective Hamiltonians for Homogenization of a class of Hamilton-Jacobi Equations

We propose a new formulation to compute effective Hamiltonians for homogenization of a class of Hamilton–Jacobi equations. Our formulation utilizes an observation made by Barron and Jensen [Comm. Partial Differential Equations, 15 (1990), pp. 1713–1742] about viscosity supersolutions of Hamilton–Jacobi equations. The key idea is to link the effective Hamiltonian to a suitable effective equation. The main advantage of our formulation is that only one auxiliary equation needs to be solved in order to compute the effective Hamiltonian H¯(p) for all p. Error estimates and stability are proved and numerical examples are presented to demonstrate the performance.
Abnormal amygdala activation profile in pedophilia

j Abstract Despite considerable public interest research in neurobiological correlates of pedophilia is scarce. Since amygdala activation is central for emotional valuation, arousal, and salience, we investigated the activation profile of this structure in 10 male subjects with pedophilia (exclusively attracted to boys), all convicted sex-offenders and sentenced to forensic psychiatric treatment along with ten male heterosexual matched controls. We used a sexually non-explicit functional Magnetic Resonance Imaging (fMRI) paradigm with images of men, women, boys or girls randomly embedded in neutral target/non-target geometrical symbols. We applied statistical parametric mapping (SPM2) and SPSS 14 for image processing and analysis. While controls activated significantly less to pictures of children compared to adults, the activation profile was reversed in subjects with pedophilia, who exhibited significantly more activation to children than adults. The highest activation was observed for boys in the patient group, and for women in control participants. Our data show enhanced activation to children’s pictures even in an incidental context and suggest the provocative hypothesis that a normally present mechanism for reduced emotional arousal for children relative to adults is reversed in pedophilia, suggesting a neural substrate associated with deviant sexual preference in this condition. More extensive research in this field would be of benefit for both the victims and the offenders.
Continuous-time non-linear flatness-based predictive control: an exact feedforward linearisation setting with an induction drive example

A general flatness-based framework for non-linear continuous-time predictive control is presented. It extends the results of Fliess and Marquez (2000) to the non-linear case. The mathematical setting, which is valid for multivariable systems, is provided by the theory of flatness-based exact feedforward linearisation introduced by the authors (Hagenmeyer and Delaleau 2003b). Thereby differential flatness does not only yield an easy calculation of the predicted trajectories considering the respective system constraints, but allows to use simple linear feedback parts in a two-degree-of-freedom control structure. Moreover, this formalism permits one to handle non-minimum phase systems, and furthermore to deal with parameter uncertainties and exogenous perturbations. Respective robustness analysis tools are available. Finally, an induction drive example is discussed in detail and experimental results for this fast electro-mechanical system are presented.
Axenfeld-Rieger Syndrome Associated with Congenital Glaucoma and Cytochrome P4501B1 Gene Mutations

Developmental anomalies of the ocular anterior chamber angle may lead to an incomplete development of the structures that form the conventional aqueous outflow pathway. Thus, disorders that present with such dysfunction tend to be associated with glaucoma. Among them, Axenfeld-Rieger (ARS) malformation is a rare clinical entity with an estimated prevalence of one in every 200,000 individuals. The changes in eye morphogenesis in ARS are highly penetrant and are associated with 50% risk of development of glaucoma. Mutations in the cytochrome P4501B1 (CYP1B1) gene have been reported to be associated with primary congenital glaucoma and other forms of glaucoma and mutations in pituitary homeobox 2 (PITX2) gene have been identified in ARS in various studies. This case was negative for PITX2 mutations and compound heterozygote for CYP1B1 mutations. Clinical manifestations of this patient include bilateral elevated intraocular pressure (>40 mmHg) with increased corneal diameter (>14 mm) and corneal opacity. Patient also had iridocorneal adhesions, anteriorly displaced Schwalbe line, anterior insertion of iris, broad nasal bridge and protruding umbilicus. This is the first study from north India reporting CYP1B1 mutations in Axenfeld-Rieger syndrome with bilateral buphthalmos and early onset glaucoma. Result of this study supports the role of CYP1B1 as a causative gene in ASD disorders and its role in oculogenesis.
An insulinoma with clinical and electroencephalographic features resembling complex partial seizures

We described a female patient with insulinoma who experienced recurrent episodes of automatism, confusion and convulsion. Furthermore, her electroencephalography (EEG) findings resembled the pattern in complex partial seizures with secondary generalization. The interictal EEG showed spikes and sharp waves, as well as focal slowing over the left temporal lobe, and the ictal EEG revealed generalized spikes and sharp waves associated with diffused slowing. She was initially misdiagnosed as pharmacoresistant epilepsy. After the insulinoma was found and surgically removed, her EEG turned normal and she was seizure-free during the 4-year follow-up. This report highlights the need for careful reassessment of all seizures refractory to medication, even for the patients associated with epileptiform discharges on EEG.
Antimicrobial knowledge and confidence amongst final year medical students in Australia

Introduction Inappropriate use of antimicrobials is one of the major modifiable contributors to antimicrobial resistance. There is currently no validated survey tool available to assess knowledge and confidence of medical students in infectious diseases (ID) compared to other diseases states, and little is known about this topic. Materials and methods A cross-sectional survey of final year medical students attending universities around Australia was conducted between August and September, 2015. A survey unique from other published studies was developed to survey satisfaction in education, confidence and knowledge in ID, and how this compared to these factors in cardiovascular diseases. Results Reliability and validity was demonstrated in the survey tool used. Students were more likely to rate university education as sufficient for cardiovascular diseases (91.3%) compared to ID (72.5%), and were more confident in their knowledge of cardiovascular diseases compared to ID (74.38% vs. 53.76%). Students tended to answer more cardiovascular disease related clinical questions correctly (mean score 78%), compared to questions on antimicrobial use (mean score 45%). Conclusions Poor knowledge and confidence amongst final year medical students in Australia were observed in ID. Antimicrobial stewardship agenda should include the provision of additional training in antimicrobial prescribing to the future medical workforce.
NEMESIS: A software approach for computing in presence of soft errors

Soft errors are considered as the main reliability challenge for sub-nanoscale microprocessors. Software-level soft error resilience schemes are desirable because they require no hardware modifications and their protection can be tuned based on the application requirements. However, existing software-level error tolerant schemes do not provide high-level of protection. In this work, we present NEMESIS — a compiler-level fine-grain soft error detection, diagnosis and recovery technique that can provide high degree of error-resiliency. NEMESIS runs three versions of computations and detects soft errors by checking the results of all memory write and branch operations. In the case of mismatch, NEMESIS recovery routine reverts the effect of error from the architectural state of the program and program resumes its normal execution. Our extensive μ-architectural-level fault injection experiments results show that NEMESIS transformation is able to detect all soft errors and recover from 97% of detected errors.
Varying Task Demonstrability to Examine the Roles of Social and Cognitive Factors in Group Transfer Learning

I investigated the importance of cognitive exposure and social interaction for group-to-individual transfer for low-and high-demonstrability tasks. I tested the hypothesis that transfer occurs for high-demonstrability tasks with or without social interaction, but transfer for lowdemonstrability tasks only occurs if subjects engage in social interaction. During the transfer phase, subjects either worked in a small group, which permitted social interaction, or viewed a video of a yolked group, which only permitted the transfer of cognitive processes. Analysis of subjects’ pre-post performance difference indicated that transfer is constant regardless of the level of demonstrability. However, overall transfer for the high demonstrability task exceeds transfer of the low demonstrability task.
The Ablation Properties of CO2 Laser Irradiating to Absorption Media: An In Vitro Study

This study aimed to compare histological affected zone of tissue samples irradiated by defocused CO2 laser at 1, 2, and 3W continuous wave with and without absorption media. The in vitro experiment was conducted in 70 tissue blocks. The samples were randomly allocated into 7 groups: 10 samples each group, namely, the groups irradiated with 1, 2, and 3W, defocused CO2 laser for 5 seconds, the groups irradiated with 1, 2, and 3W, defocused CO2 laser to the absorption media, and the media alone group as a control. Then the samples were stained with Masson's trichrome and measured the affected borders under light microscope at 10 × 10 magnification. There was no histological alteration in the groups irradiated with the defocused CO2 laser to the absorption media while the groups without using the absorption media showed the tissue alteration by photoablation.
Vaccination coverage in French 17-year-old young adults: an assessment of mandatory and recommended vaccination statuses

SUMMARY We aimed to assess vaccination coverage (VC) in 17-year-old French young adults (YAs) participating in one mandatory Day of Defence and Citizenship (DDC). Between June 2010 and May 2011, YAs participating in 43 randomly selected mandatory sessions of the DDC programme in Poitou-Charentes (France) were asked to provide their personal vaccination record. Tetanus, diphtheria, polio, hepatitis B, Haemophilus influenzae b, pertussis, measles, mumps and rubella vaccination status were assessed at ages 2, 6, 13 and 17 years. Of 2610 participants, 2111 (81%) supplied documents for evaluation. Of these, 1838 (87%, M:F sex ratio 0·96) were aged 17 years (9% of the global population of this age in the area). The assessment of the 17-year-olds demonstrated the following rates of complete vaccination: diphtheria-tetanus-polio 83%; measles, mumps and rubella 83%; pertussis 69%; H. influenzae b 61%; human papillomavirus 47%; and hepatitis B 40%. At age 6 years, only 46% had received two doses of the vaccine against measles. The YAs were not aware of their status but were in favour of vaccination. VC in YAs is insufficient, particularly for hepatitis B, pertussis and measles. Combined vaccines and the simplification of vaccination schedules should improve VC. Preventive messages should focus on YAs.
Students’ Perceptions of Fairness in School Settings: A Gender Analysis

In this study, we explored gender differences in students’ perceptions of fairness in two southwestern schools. In particular, we surveyed 358 students in a junior high and 373 in a high school and examined how males and females differed with respect to how they perceived the fairness of their school and classes. Results suggest that gender differences in students’ perceptions of fairness were pervasive. Specifically, in the high school, females more frequently than males reported they felt their school was fair in terms of personal experiences. In contrast, females in the junior high school more frequently than males reported their school was fair in terms of SES and ethnicity differences. Data suggest that some schools may create an environment in which peer norms support school achievement. We predict that students’ perceptions of fairness mediate students outcomes within a classroom context; however, more research is needed to explicitly examine how fairness mediates students’ sense of community and academic performance.
Effects of Intronic and Exonic Polymorphisms of Paraoxonase 1 (PON1) Gene on Serum PON1 Activity in a Korean Population

Paraoxonase 1 (PON1) hydrolyzes a number of toxic organophosphorous compounds and reduces lipid peroxide accumulation, and PON1 genetic polymorphisms in the coding region modulate serum PON1 activity. In this study, we investigated the association between 3 polymorphisms of PON1 located in intron 5 (17899insdelTT and 17974CT) and exon 6 (192QR) and serum PON1 activity. The genetic polymorphisms and serum activity of PON1 were analyzed in 153 healthy Koreans by using a direct sequencing assay and spectrophotometric method, respectively. A significant linkage disequilibrium (LD) was observed between all tested single nucleotide polymorphisms, with the strongest LD observed between 17899insdelTT and 192QR (D' = 0.984). The 17899insdelTT, 17974CT and 192QR genetic polymorphisms were associated with significant differences in serum paraoxonase activity. In multiple regression analyses, smoking, triglyceride level, high-density lipoprotein (HDL) level, and the 17899insdelTT and 192QR genetic polymorphisms were significant determinants of serum paraoxonase activity, while age, smoking, triglyceride level, HDL level, and the 192QR genetic polymorphism were significant determinants of serum arylesterase activity. These results suggest that although the 192QR genetic polymorphism in the coding region of PON1 is primarily associated with serum PON1 activity, the intronic polymorphisms are also involved in serum PON1 activity, and this association may be mediated by LD.