Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Influencing the Emergence and Spread of HIV Drug Resistance Arising from Rollout of Antiretroviral Pre-Exposure Prophylaxis (PrEP)

Background The potential for emergence and spread of HIV drug resistance from rollout of antiretroviral (ARV) pre-exposure prophylaxis (PrEP) is an important public health concern. We investigated determinants of HIV drug resistance prevalence after PrEP implementation through mathematical modeling. Methodology A model incorporating heterogeneity in age, gender, sexual activity, HIV infection status, stage of disease, PrEP coverage/discontinuation, and HIV drug susceptibility, was designed to simulate the impact of PrEP on HIV prevention and drug resistance in a sub-Saharan epidemic. Principal Findings Analyses suggest that the prevalence of HIV drug resistance is influenced most by the extent and duration of inadvertent PrEP use in individuals already infected with HIV. Other key factors affecting drug resistance prevalence include the persistence time of transmitted resistance and the duration of inadvertent PrEP use in individuals who become infected on PrEP. From uncertainty analysis, the median overall prevalence of drug resistance at 10 years was predicted to be 9.2% (interquartile range 6.9%–12.2%). An optimistic scenario of 75% PrEP efficacy, 60% coverage of the susceptible population, and 5% inadvertent PrEP use predicts a rise in HIV drug resistance prevalence to only 2.5% after 10 years. By contrast, in a pessimistic scenario of 25% PrEP efficacy, 15% population coverage, and 25% inadvertent PrEP use, resistance prevalence increased to over 40%. Conclusions Inadvertent PrEP use in previously-infected individuals is the major determinant of HIV drug resistance prevalence arising from PrEP. Both the rate and duration of inadvertent PrEP use are key factors. PrEP rollout programs should include routine monitoring of HIV infection status to limit the spread of drug resistance.
Pan-HSV-2 IgG Antibody in Vaccinated Mice and Guinea Pigs Correlates with Protection against Herpes Simplex Virus 2

We lack a correlate of immunity to herpes simplex virus 2 (HSV-2) that may be used to differentiate whether a HSV-2 vaccine elicits robust or anemic protection against genital herpes. This gap in knowledge is often attributed to a failure to measure the correct component of the adaptive immune response to HSV-2. However, efforts to identify a correlate of immunity have focused on subunit vaccines that contain less than 3% of HSV-2's 40,000-amino-acid proteome. We were interested to determine if a correlate of immunity might be more readily identified if 1. animals were immunized with a polyvalent immunogen such as a live virus and/or 2. the magnitude of the vaccine-induced immune response was gauged in terms of the IgG antibody response to all of HSV-2's antigens (pan-HSV-2 IgG). Pre-challenge pan-HSV-2 IgG levels and protection against HSV-2 were compared in mice and/or guinea pigs immunized with a gD-2 subunit vaccine, wild-type HSV-2, or one of several attenuated HSV-2 ICP0 − viruses (0Δ254, 0Δ810, 0ΔRING, or 0ΔNLS). These six HSV-2 immunogens elicited a wide range of pan-HSV-2 IgG levels spanning an ∼500-fold range. For 5 of the 6 immunogens tested, pre-challenge levels of pan-HSV-2 IgG quantitatively correlated with reductions in HSV-2 challenge virus shedding and increased survival frequency following HSV-2 challenge. Collectively, the results suggest that pan-HSV-2 IgG levels may provide a simple and useful screening tool for evaluating the potential of a HSV-2 vaccine candidate to elicit protection against HSV-2 genital herpes.
The Interaction of Coarticulation and Prosody in Sound Change

Ohala (1974, 1981a) has proposed that sound changes can originate in hearers' misinterpretations of synchronic phonetic patterns. This paper applies this idea to sound changes that are conditioned by the prosodic environment, such as the voicing of voiceless fricatives in unstressed syllables in Proto-Germanic. Browman and Goldstein's (1989, 1990) “gestural score” suggests a representation of synchronic patterns in which extreme overlap between gestures of neighboring phoneme segments in casual speech can produce the appearance of a feature change or a segment deletion. Many of the sound changes that are conditioned by prosodic environment can be viewed as a diachronic reinterpretation of just such synchronic fast-speech processes. For example, vowel reduction in unstressed syllables can be viewed as a reinterpretation of undershoot that occurs when the vowel is overlapped to a great extent by the oral gestures for neighboring consonants. Phonetic data are reviewed that support analogous accounts of stop spirantization, voiceless obstruent voicing, and even the insertion of an intrusive stop in clusters such as /ns/ in some prosodic environments.
Surrounded by violence: How do individual perceptions and community context shape views about violence?

In this paper we examine the community- and individual-level characteristics associated with individuals’ perceptions of violence. We use data collected in the Australian Community Capacity Study Wave 3 survey of over 4000 individuals living in 148 local residential communities in Brisbane and employ multilevel models to examine the association between community context, individual perceptions of police effectiveness and the belief that people in one’s community support violence to resolve conflict. We find communities with histories of violent crime and more negative views about police effectiveness tend to be communities where residents perceive their neighbours will support the use of violence to resolve conflict.
Visually Lossless Accuracy of Motion Vector in Overcomplete Wavelet-based Scalable Video Coding

In this paper, we propose a visually lossless accuracy model for scalable coding of motion vectors in overcomplete wavelet-based scalable video codec. By exploiting theory of stationary random process, we first estimate motion compensation errors in spatial domain due to inaccurate motion vectors. We then extend the results to overcomplete wavelet domain, and further derive the errors caused by fraction-pixel motion vectors. Finally, combining with a visibility model of wavelet coefficient errors, we propose a novel algorithm to estimate the accuracy threshold of motion vectors with which motion compensation errors will be invisible. Experimental results show that our algorithm is effective in estimating visually lossless accuracy threshold of motion vectors. The proposed algorithm can also be used in scalable motion estimation in wavelet domain. It can accelerate motion estimation speed by stopping halfway at the accuracy that will not cause any visible errors.
Predicting undergraduates' entrepreneurial intentions: a values approach

A productive area for entrepreneurial research is to investigate the relationship between entrepreneurial values and entrepreneurial activities. In light of this suggestion, the purpose of this study is to test the utility of values theory to predict undergraduate students' entrepreneurial intentions. The results suggest the simultaneous influence of the three salient values of achievement, stimulation and hedonism on undergraduate students' entrepreneurial intentions. The significance of achievement and stimulation compliment earlier studies whereas the significance of hedonism (negatively) extends the notion of entrepreneurial values. Implications from this research are that undergraduate students' entrepreneurial intentions can be promoted by inculcating and activating salient entrepreneurial values. Besides this, an entrepreneurial development programme can specifically target undergraduate students who possessed salient entrepreneurial values for greater effectiveness.
Task-dependent V1 responses in human retinitis pigmentosa.

PURPOSE During measurement with functional MRI (fMRI) during passive viewing, subjects with macular degeneration (MD) have a large unresponsive lesion projection zone (LPZ) in V1. fMRI responses can be evoked from the LPZ when subjects engage in a stimulus-related task. The authors report fMRI measurements on a different class of subjects, those with retinitis pigmentosa (RP), who have intact foveal vision but peripheral visual field loss. METHODS The authors measured three RP subjects and two control subjects. fMRI was performed while the subjects viewed drifting contrast pattern stimuli. The subjects passively viewed the stimuli or performed a stimulus-related task. RESULTS During passive viewing, the BOLD response in the posterior calcarine cortex of all RP subjects was in phase with the stimulus. A bordering, anterior LPZ could be identified by responses that were in opposite phase to the stimulus. When the RP subjects made stimulus-related judgments, however, the LPZ responses changed: the responses modulated in phase with the stimulus and task. In control subjects, the responses in a simulated V1 LPZ were unchanged between the passive and the stimulus-related judgment conditions. CONCLUSIONS Task-dependent LPZ responses are present in RP subjects, similar to responses measured in MD subjects. The results are consistent with the hypothesis that deleting the retinal input to the LPZ unmasks preexisting extrastriate feedback signals that are present across V1. The authors discuss the implications of this hypothesis for visual therapy designed to replace the missing V1 LPZ inputs and to restore vision.
An Accretion Model for the Growth of the Central Black Hole Associated with Ionization Instability in Quasars

A possible accretion model associated with the ionization instability of quasar disks is proposed to address the growth of the central black hole (BH) harbored in the host galaxy. The evolution of quasars in cosmic time is assumed to change from a highly active state to a quiescent state triggered by the S-shaped ionization instability of the quasar accretion disk. For a given external mass transfer rate Ṁext supplied by the quasar host galaxy, ionization instability can modify the accretion rate in the disk and separate the accretion flows of the disk into three different phases, like an S-shape. We suggest that the bright quasars observed today are those quasars with disks in the upper branch of the S-shaped instability, and the faint or "dormant" quasars are simply these systems in the lower branch. The middle branch is the transition state, which is unstable. We assume the quasar disk evolves according to the advection-dominated inflow-outflow solution (ADIOS) configuration in the stable lower branch of the S-shaped instability, and the Eddington accretion rate is used to constrain the accretion rate in the highly active phase. The mass ratio between a BH and its host galactic bulge is a natural consequence of an ADIOS. Our model also demonstrates that a seed BH (~2 × 106 M☉) similar to those found in spiral galaxies today is needed to produce a BH with a final mass of ~2 × 108 M☉.
A Correlation Analysis of Order Aggressiveness

We give a new definition of order aggressiveness based jointly on three major concepts: time, price and quantity. Using correlations on an original dataset derived by reconstructing limit order book, we analyze to what level aggressiveness on one side affects the aggressiveness on both sides of trading. Besides, we provide further evidence of intraday effects in orders and trades.
Prospective writing: Randomized controlled trial of an intervention for facilitating growth after adversity

Abstract Little is known about how posttraumatic growth (PTG) can be fostered and controversy surrounds how it is best measured. We designed and tested an intervention, prospective writing, to facilitate PTG by encouraging people to explore new possibilities after adversity. Adults (N = 188) with recent adverse experiences were randomly assigned to do prospective writing, factual writing, or no writing weekly for one month. PTG was assessed with both retrospective and current-standing measures. Hierarchical linear modeling and response profile analysis were used to assess the intervention’s impact, and latent growth curve modeling was used to test mediation. Prospective writing participants showed the greatest gains in PTG as assessed by the current-standing measure, but did not reliably show greater retrospective PTG than controls. Although large effect sizes for the mediation paths suggested that engagement with new possibilities may be a plausible mechanism, this result fell short of statistical significance. Prospection-based interventions merit further investigation.
Preschool Teacher Knowledge and Skills: Phonemic Awareness and Instruction.

iii ACKNOWLEDGEMENTS . v LIST OF TABLES . x CHAPTER ONE INTRODUCTION . 1 Early Childhood Educators’ Knowledge and Skills Related to Phonemic Awareness . 7 Statement of Problem . 8 Purpose of the Study . 9 Research Questions . 9 Significance of the Study . 10 Limitations of the Study.10 Definitions of Terms . 11 Summary . 13 CHAPTER TWO REVIEW OF RELATED LITERATURE . 16 Search Procedures for Related Literature . 17 Criteria for Selection . 18 Historical Perspective . 18 National Early Childhood Leadership Perspective . 23 Preschool Phonemic Awareness Instruction . 26 Current Trends in Early Literacy Research . 30 Summary . 34
Chemotherapy plus Erlotinib versus Chemotherapy Alone for Treating Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

Background Whether a combination of chemotherapy and erlotinib is beneficial for advanced non-small cell lung cancer (NSCLC) remains controversial. This study aimed to summarize the currently available evidence and compare the efficacy and safety of chemotherapy plus erlotinib versus chemotherapy alone for treating advanced NSCLC. Methods EMBASE, PubMed, and the Cochrane Central Register of Controlled Trials were searched for relevant studies. Our protocol was registered in PROSPERO (CRD42014015015). Results Nine randomized controlled trials with a total of 3599 patients were included. Compared to chemotherapy alone, chemotherapy plus erlotinib was superior in PFS (HR = 0.76 [95% CI 0.62, 0.92], P = 0.006), and no statistically significant difference was observed in OS (HR = 0.94 [95% CI 0.86, 1.03], P = 0.16). Intercalated erlotinib plus chemotherapy demonstrated improvements in PFS (HR = 0.67 [95% CI 0.50, 0.91], P = 0.009) and OS (HR = 0.82 [95% CI 0.69, 0.98], P = 0.03). Continuous erlotinib plus chemotherapy treatment failed to demonstrate improvements in PFS (HR = 0.91 [95% CI 0.80, 1.04], P = 0.16) and OS (HR = 0.98 [95% CI 0.89, 1.09], P = 0.75). The association of chemotherapy plus erlotinib with improvement in PFS was significant in never smoking patients (HR = 0.46 [95% CI 0.37, 0.56], P<0.00001) but not in smoking patients (HR = 0.70 [95% CI 0.49, 1.00], P = 0.05). Among patients with EGFR mutant tumors, chemotherapy plus erlotinib demonstrated significant improvements in PFS (HR = 0.31 [95% CI 0.17, 0.58], P = 0.0002) and OS (HR = 0.52 [95% CI 0.30, 0.88], P = 0.01). Among patients with EGFR wild-type tumors, no statistically significant difference was observed with respect to PFS (HR = 0.87 [95% CI 0.70, 1.08], P = 0.21) and OS (HR = 0.78 [95% CI 0.59, 1.01], P = 0.06). Conclusion Combination of chemotherapy and erlotinib is a viable treatment option for patients with NSCLC, especially for patients who never smoked and patients with EGFR mutation-positive disease. In addition, intercalated administration is an effective combinatorial strategy.
STUDY OF THE WEAK INTERACTIONS BY MEANS OF ATOMIC AND MOLECULAR SPECTROSCOPY

The story about the study of the weak interaction of elementary particles demonstrates curious entanglements in modern physics. Weak interactions grow with energy and, thus, it seems impractical to study them at virtually zero energy typical to atomic physics. The typical scale of weak interactions in atomic physics is: 16 10 ≈ ∆E / H where H is the matrix element of the weak interaction and Ry E ≈ ∆ is a typical energy interval. Nevertheless, the high accuracy of atomic theory and the extremely high sensitivity of atomic experiments made it competitive with high-energy physics and its high investments. For the first time it was demonstrated during the study of the parity nonconserving (PNC) weak neutral electron-nucleon currents, which was found to be in agreement with standard model (SM) [1]. Since then, there are two trends in the study of the weak interactions: the continuous growth of the energy and investments in the high-energy physics in order to find new fundamental particles and growth in the accuracy of both theory and experiment in the atomic physics. At present, the sensitivity of atomic methods is high enough to test SM at the level of radiative corrections. The atomic physics can also feel the existence of new particles, such as the second Zboson, or leptoquark on a TeV scale. The experimental search for the permanent electric dipole moments (EDMs) of atoms and molecules provides another powerful tool for study of even weaker interaction, which violates both parity (P) and timereversal invariance (T). In SM Pand T-violation is introduced via CM matrix. This mechanism leads to extremely small EDMs of elementary particles, far beyond the reach of modern experimental techniques. However, virtually all the extensions of SM predict much larger EDMs. In particular, the super-symmetric models and Left-Right models predict EDMs close to the modern experimental limit [2]. In fact, the modern experimental limits on the EDMs of heavy atoms provide the most sensitive tests of these theories. The search for the P-odd and P,T-odd phenomena in atoms and molecules pushed forward atomic and molecular theory as well as experimental techniques. For the interpretation of the first PNC experiments in atoms the 10% accuracy of the theory was sufficient, but now it is vital to provide 1% accuracy in order to test SM at the level of radiation corrections. Here in PNPI, we started to work in this direction in 1981 after detailed discussions in the group of V.M. Lobashev. We were mostly interested in the new possibilities to study P,T-odd interactions in molecules. As a result of those discussions, V.M. Lobashev assigned new experimental group. That group had to start from the very entry-level, as the Petersburg Nuclear Physics Institute had neither equipment nor expertise in molecular beam techniques. It was also imperative to provide a necessary theoretical background in atomic and molecular calculations to support these experiments.
Probing the Shape of the Galactic Halo with Hypervelocity Stars

Precise proper-motion measurements (σμ ~ 10 μas yr-1) of the recently discovered hypervelocity star (HVS) SDSS J090745.0+024507 would yield significant constraints on the axis ratios and orientation of a triaxial model for the Galactic halo. Triaxiality of dark matter halos is predicted by cold dark matter models of galaxy formation and may be used to probe the nature of dark matter. However, unless the distance to this star is determined to better than 10%, these constraints suffer from one-dimensional degeneracies, which we quantify. We show how proper-motion measurements of several HVSs could simultaneously resolve the distance degeneracies of all such stars and produce a detailed picture of the triaxial halo. Additional HVSs may be found from radial velocity surveys or from parallax/proper-motion data derived from Gaia. High-precision proper-motion measurements of these stars using the Space Interferometry Mission (SIM PlanetQuest) would substantially tighten the constraints they yield on the Galactic potential.
Auditory brainstem response to complex sounds predicts self-reported speech-in-noise performance.

PURPOSE To compare the ability of the auditory brainstem response to complex sounds (cABR) to predict subjective ratings of speech understanding in noise on the Speech, Spatial, and Qualities of Hearing Scale (SSQ; Gatehouse & Noble, 2004) relative to the predictive ability of the Quick Speech-in-Noise test (QuickSIN; Killion, Niquette, Gudmundsen, Revit, & Banerjee, 2004) and pure-tone hearing thresholds. METHOD Participants included 111 middle- to older-age adults (range = 45-78) with audiometric configurations ranging from normal hearing levels to moderate sensorineural hearing loss. In addition to using audiometric testing, the authors also used such evaluation measures as the QuickSIN, the SSQ, and the cABR. RESULTS Multiple linear regression analysis indicated that the inclusion of brainstem variables in a model with QuickSIN, hearing thresholds, and age accounted for 30% of the variance in the Speech subtest of the SSQ, compared with significantly less variance (19%) when brainstem variables were not included. CONCLUSION The authors' results demonstrate the cABR's efficacy for predicting self-reported speech-in-noise perception difficulties. The fact that the cABR predicts more variance in self-reported speech-in-noise (SIN) perception than either the QuickSIN or hearing thresholds indicates that the cABR provides additional insight into an individual's ability to hear in background noise. In addition, the findings underscore the link between the cABR and hearing in noise.
Play in the primary school classroom? The experience of teachers supporting children’s learning through a new pedagogy

In Scotland in recent years there has been growing interest in a more play‐based pedagogy commonly described as Active Learning. The research reported in this article is an exploration of moves towards creating an active play‐based learning environment in six Primary 1 classrooms in Scotland and is concerned with (i) the children’s experiences in such a play‐based active learning environment in school and (ii) their teachers’ perspectives on this pedagogical innovation and their roles in supporting the learners. This study examined experiences and perspectives within and across each of the six child‐centred and play‐focused classes. The main findings suggest that the role of the teacher varies between what could be considered as teacher‐intensive and teacher‐initiated activities. ‘Active’ or ‘play‐based’ learning was interpreted differently by teachers; play in some classrooms was peripheral rather than integral to the learning process and curriculum‐embedded.