Miracle-dz/UniFAR-FTUs huggingface dataset:
THE ELEVENTH AND TWELFTH DATA RELEASES OF THE SLOAN DIGITAL SKY SURVEY: FINAL DATA FROM SDSS-III

The third generation of the Sloan Digital Sky Survey (SDSS-III) took data from 2008 to 2014 using the original SDSS wide-field imager, the original and an upgraded multi-object fiber-fed optical spectrograph, a new near-infrared high-resolution spectrograph, and a novel optical interferometer. All of the data from SDSS-III are now made public. In particular, this paper describes Data Release 11 (DR11) including all data acquired through 2013 July, and Data Release 12 (DR12) adding data acquired through 2014 July (including all data included in previous data releases), marking the end of SDSS-III observing. Relative to our previous public release (DR10), DR12 adds one million new spectra of galaxies and quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) over an additional 3000 deg2 of sky, more than triples the number of H-band spectra of stars as part of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE), and includes repeated accurate radial velocity measurements of 5500 stars from the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS). The APOGEE outputs now include the measured abundances of 15 different elements for each star. In total, SDSS-III added 5200 deg2 of ugriz imaging; 155,520 spectra of 138,099 stars as part of the Sloan Exploration of Galactic Understanding and Evolution 2 (SEGUE-2) survey; 2,497,484 BOSS spectra of 1,372,737 galaxies, 294,512 quasars, and 247,216 stars over 9376 deg2; 618,080 APOGEE spectra of 156,593 stars; and 197,040 MARVELS spectra of 5513 stars. Since its first light in 1998, SDSS has imaged over 1/3 of the Celestial sphere in five bands and obtained over five million astronomical spectra.
Macrophage-Derived Factors Stimulate Optic Nerve Regeneration

After optic nerve injury in mature mammals, retinal ganglion cells (RGCs) are normally unable to regenerate their axons and undergo delayed apoptosis. However, if the lens is damaged at the time of nerve injury, many RGCs survive axotomy and regenerate their axons into the distal optic nerve. Lens injury induces macrophage activation, and we show here that factors secreted by macrophages stimulate RGCs to regenerate their axons. When macrophages were activated by intravitreal injections of Zymosan, a yeast cell wall preparation, the number of RGC axons regenerating into the distal optic nerve was even greater than after lens injury. These effects were further enhanced if Zymosan was injected 3 d after nerve crush. In a grafting paradigm, intravitreal Zymosan increased the number of RGCs that regenerated their axons through a 1.5 cm peripheral nerve graft twofold relative to uninjected controls and threefold if injections were delayed 3 d. In cell culture, media conditioned by activated macrophages stimulated adult rat RGCs to regenerate their axons; this effect was potentiated by a low molecular weight factor that is constitutively present in the vitreous humor. After gel-filtration chromatography, macrophage-derived proteins ≥30 kDa were found to be toxic to RGCs, whereas proteins <30 kDa reversed this toxicity and promoted axon regeneration. The protein(s) that stimulated axon growth is distinct from identified polypeptide trophic factors that were tested. Thus, macrophages produce proteins with both positive and negative effects on RGCs, and the effects of macrophages can be optimized by the timing of their activation.
Arabidopsis Ubiquitin Conjugase UBC32 Is an ERAD Component That Functions in Brassinosteroid-Mediated Salt Stress Tolerance[W][OA]

This work demonstrates that the Arabidopsis thaliana ubiquitin conjugation enzyme UBC32 is a component of the plant endoplasmic reticulum (ER)-associated protein degradation pathway. Biochemical and genetic studies demonstrate the functional connection between ER-associated protein degradation and brassinosteroid-mediated salt stress signaling. Plants modify their growth and development to protect themselves from detrimental conditions by triggering a variety of signaling pathways, including the activation of the ubiquitin-mediated protein degradation pathway. Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is an important aspect of the ubiquitin-proteasome system, but only a few of the active ERAD components have been reported in plants. Here, we report that the Arabidopsis thaliana ubiquitin-conjugating enzyme, UBC32, a stress-induced functional ubiquitin conjugation enzyme (E2) localized to the ER membrane, connects the ERAD process and brassinosteroid (BR)-mediated growth promotion and salt stress tolerance. In vivo data showed that UBC32 was a functional ERAD component that affected the stability of a known ERAD substrate, the barley (Hordeum vulgare) powdery mildew O (MLO) mutant MLO-12. UBC32 mutation caused the accumulation of bri1-5 and bri1-9, the mutant forms of the BR receptor, BRI1, and these mutant forms subsequently activated BR signal transduction. Further genetic and physiological data supported the contention that UBC32 plays a role in the BR-mediated salt stress response and that BR signaling is necessary for the plant to tolerate salt. Our data indicates a possible mechanism by which an ERAD component regulates the growth and stress response of plants.
Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks

We provide evidence that NMDARs within murine spinal locomotor networks determine the frequency and amplitude of ongoing locomotor-related activity in vitro and that NMDARs are regulated by d-serine and glycine in a synapse-specific and activity-dependent manner. In addition, glycine transporter-1 is shown to be an important regulator of NMDARs during locomotor-related activity. These results show how excitatory transmission can be tuned to diversify the output repertoire of spinal locomotor networks in mammals.
Comparison of Self-Collected and Physician-Collected Vaginal Swabs for Microbiome Analysis

ABSTRACT To our knowledge, no data are available on whether the microbial species composition and abundance sampled with self-collected vaginal swabs are comparable to those of swabs collected by clinicians. Twenty healthy women were recruited to the study during a routine gynecological visit. Eligible women were between 18 and 40 years old with regular menstrual cycles. Participants self-collected a vaginal swab using a standardized protocol and then were examined by a physician, who collected an additional five swabs from the lateral wall of the mid-vagina. In this study, the self-collected and three physician-obtained swabs were analyzed and compared using terminal restriction fragment length polymorphism and sequence analyses of the 16S rRNA genes. Vaginal microbial community comparative statistical analyses of both T-RFLP and 16S rRNA gene sequence datasets revealed that self-collected vaginal swabs sampled the same microbial diversity as physician collected swabs of the mid-vagina. These findings enable large-scale, field-based studies of the vaginal microbiome.
Soil Seed Bank and Plant Community Development in Passive Restoration of Degraded Sandy Grasslands

To evaluate the efficacy of passive restoration on soil seed bank and vegetation recovery, we measured the species composition and density of the soil seed bank, as well as the species composition, density, coverage, and height of the extant vegetation in sites passively restored for 0, 4, 7, and 12 years (S0, S4, S7, and S12) in a degraded grassland in desert land. Compared with S0, three more species in the soil seed bank at depths of 0–30 cm and one more plant species in the community was detected in S12. Seed density within the topsoil (0–5 cm) was five times higher in S12 than that in S0. Plant densities in S7 and S12 were triple and quadruple than that in S0. Plant coverage was increased by 1.5 times (S4), double (S7), and triple (S12) compared with S0. Sorensen’s index of similarity in species composition between the soil seed bank and the plant community were high (0.43–0.63), but it was lower in short-term restoration sites (S4 and S7) than that in no and long-term restoration sites (S0 and S12). The soil seed bank recovered more slowly than the plant community under passive restoration. Passive restoration is a useful method to recover the soil seed bank and vegetation in degraded grasslands.
Retention of three endodontic posts cemented with adhesive resin cement

Background: An extensive review of published articles has revealed a wide divergence of opinions regarding the suitability of different post systems for endodontically treated teeth. As a result the dentist has no clear guidelines concerning the selection of suitable post systems that will provide adequate retention while minimizing subsequent root fracture. This invitro study formulated to compare the retentive abilities of three different post systems (Euro post, Easy post, custom cast post) using adhesive resin cement. Materials and methods: Twenty four intact human mandibular second premolars were selected for this study. These samples were endodonticlly treated, and randomly divided in to three groups of eight teeth each: Group Ι: teeth restored with Euro post (prefabricated parallel sided stainless steel/ serrated posts). Group ΙΙ: teeth restored with custom cast posts design. Group ΙΙΙ: teeth restored with Easy post (prefabricated fiber reinforced composite post/smooth/tapered). Tensile failure loads were measured in the absence of crowns using an instron test machine at across head speed of 5 mm/min. Values were recorded in Newton . Mean values and standard deviations were analyzed with one way ANOVA test and the least significant differences test. Results: Retentive failure loads were recorded for all test specimens; the means and standard deviation for each group were as follows: group Ι: 189±68.9; group ΙΙ:79.13 ±17.80and groupΙΙΙ:65.75±23.61. Conclusion: Endodontically treated teeth restored with Euro post (stainless steel/parallel sided /serrated posts) showed significantly greater retentive forces than teeth restored with cast post and Easy post "fiber reinforced posts (tapered design)", also the difference in the mean retentive failure values between specimens restored with cast post and Easy post was not statistically significant.
Examining the aetiopathogenesis of varicoceles: the relationship between retroperitoneal adipose tissue and testicular venous drainage

This study evaluated the effect of retroperitoneal adipose tissue on testicular venous drainage and tested the nutcracker phenomenon by clinical and imaging findings. A total of 95 patients were included. The patients were evaluated with a detailed medical history and physical examination for varicocele. Their weight, height and waist circumference were also recorded. Body mass index was calculated as weight (kg)/height squared (m2). Pampiniform plexus diameters were measured by scrotal colour Doppler ultrasonography, and retroperitoneal adipose tissue was evaluated by noncontrast abdominal computed tomography. We determined an almost significant correlation between BMI and varicocele presence by physical examination (P = 0.06). However, there was a significant relationship between WC and varicocele identified by physical examination (P = 0.021). There was a positive and significant relationship between BMI and pampiniform plexus diameters. Furthermore, we detected a negative correlation between retroperitoneal adipose tissue measurements and CDU findings. Additionally, there was a significant correlation between WC, pampiniform plexus diameters and CT findings. It is concluded that increasing BMI and increasing WC may play a protective role in the development of varicocele. There is a need for further studies to verify the effect of obesity on varicocele formation.
Effect of Fines on the Properties of Fibre Networks

The fines of mechanical and chemical pulps have a character very distinct from their respective fibre fractions. The fines can be regarded as a special furnish component and the optimum quality and percentage of fines in the sheet depends on the properties of the fibre fraction used. An addition of suitable fines can improve remarkably the properties of a printing paper. This paper deals with the structural, optical and strength properties of fibre networks, as influenced by fibre coarseness and the introduction of different types of fines. The response of these networks to calendering is also studied. Fibre fractions of different coarseness and lignin content are used. Confocal laser scanning microscopy (CLSM) is used to determine the changes in the structure and microscopic roughness of the sheet.
Blueberry Supplemented Diet: Effects on Object Recognition Memory and Nuclear Factor-kappa B Levels in Aged Rats

Abstract It has been reported that an antioxidant-rich, blueberry-supplemented rat diet may retard brain aging in the rat. The present study determined whether such supplementation could prevent impaired object recognition memory and elevated levels of the oxidative stress-responsive protein, nuclear factor-kappa B (NF-κB) in aged Fischer-344 rats. Twelve aged rats had been fed a 2% blueberry supplemented diet for 4 months prior to testing. Eleven aged rats and twelve young rats had been fed a control diet. The rats were tested for object recognition memory on the visual paired comparison task. With a 1-h delay between training and testing, aged control diet rats performed no better than chance. Young rats and aged blueberry diet rats performed similarly and significantly better than the aged control diet group. Levels of NF-κB in five brain regions of the above subjects were determined by western blotting assays. In four regions, aged control diet rats had significantly higher average NF-κB levels than young animals on the control diet. In four regions, aged blueberry diet rats had significantly lower levels of NF-κB than aged control diet rats. Normalized NF-κB levels (averaged across regions and in several individual regions) correlated negatively and significantly with the object memory scores.
SPECTROSCOPIC DETERMINATION OF MASSES (AND IMPLIED AGES) FOR RED GIANTS

The mass of a star is arguably its most fundamental parameter. For red giant stars, tracers luminous enough to be observed across the Galaxy, mass implies a stellar evolution age. It has proven to be extremely difficult to infer ages and masses directly from red giant spectra using existing methods. From the Kepler and apogee surveys, samples of several thousand stars exist with high-quality spectra and asteroseismic masses. Here we show that from these data we can build a data-driven spectral model using The Cannon, which can determine stellar masses to ∼0.07 dex from apogee dr12 spectra of red giants; these imply age estimates accurate to ∼0.2 dex (40%). We show that The Cannon constrains these ages foremost from spectral regions with CN absorption lines, elements whose surface abundances reflect mass-dependent dredge-up. We deliver an unprecedented catalog of 70,000 giants (including 20,000 red clump stars) with mass and age estimates, spanning the entire disk (from the Galactic center to kpc). We show that the age information in the spectra is not simply a corollary of the birth-material abundances and , and that, even within a monoabundance population of stars, there are age variations that vary sensibly with Galactic position. Such stellar age constraints across the Milky Way open up new avenues in Galactic archeology.
Asynchronous Stochastic Proximal Optimization Algorithms with Variance Reduction

Regularized empirical risk minimization (R-ERM) is an important branch of machine learning, since it constrains the capacity of the hypothesis space and guarantees the generalization ability of the learning algorithm. Two classic proximal optimization algorithms, i.e., proximal stochastic gradient descent (ProxSGD) and proximal stochastic coordinate descent (ProxSCD) have been widely used to solve the R-ERM problem. Recently, variance reduction technique was proposed to improve ProxSGD and ProxSCD, and the corresponding ProxSVRG and ProxSVRCD have better convergence rate. These proximal algorithms with variance reduction technique have also achieved great success in applications at small and moderate scales. However, in order to solve large-scale R-ERM problems and make more practical impacts, the parallel versions of these algorithms are sorely needed. In this paper, we propose asynchronous ProxSVRG (Async-ProxSVRG) and asynchronous ProxSVRCD (Async-ProxSVRCD) algorithms, and prove that Async-ProxSVRG can achieve near linear speedup when the training data is sparse, while Async-ProxSVRCD can achieve near linear speedup regardless of the sparse condition, as long as the number of block partitions are appropriately set. We have conducted experiments on a regularized logistic regression task. The results verified our theoretical findings and demonstrated the practical efficiency of the asynchronous stochastic proximal algorithms with variance reduction.
Asymptotic analysis and extinction in a stochastic Lotka-Volterra model

with positive xo, yo and positive parameters a, b, c, b describes a behavior of a predator-prey system in terms of the prey and predator "intensities" xt and yt. Here, a is the rate of increase of prey in the absence of predator, b is a rate of decrease of predator in the absence of prey while the rate of decrease in prey is proportional to the number of predators byt, and similarly the rate of increase in predator is proportional to the number of prey cxt [see, e.g., May (1976)]. The system (1.1) is one of the simplest nonlinear systems. Since the population numbers are discrete, a description of the predatorprey model in terms of continuous intensities xt, yt is based implicitly on a natural assumption that the numbers of both populations are large, and the intensities are obtained by a normalization of population numbers by a large parameter K. Thus (1.1) is an approximation, an asymptotic description of the interaction between the predator and prey. Although this model may capture some essential elements in that interaction, it is not suitable to answer questions of extinction of populations, as the extinction never occurs in the deterministic model; see Figure 1 for the pair xt, yt in the phase plane. We introduce here a probabilistic model which has as its limit the deterministic Lotka-Volterra model, evolves in continuous time according to the same local interactions and allows evaluating asymptotically the time for extinction of prey species. There is a vast amount of literature on the Lotka-Volterra model, and a history of research on stochastic perturbations of this system both exact, approx-
Identification of a 30-Base Pair Regulatory Element and Novel DNA Binding Protein That Regulates the Human GLUT4 Promoter in Transgenic Mice*

We have previously demonstrated that the important cis-acting elements regulating transcription of the human GLUT4 gene reside within 895 base pairs (bp) upstream of the transcription initiation site (Thai, M. V., Guruswamy, S., Cao, K. T., Pessin, J. E., and Olson, A. L. (1998) J. Biol. Chem. 273, 14285–14292). Our studies demonstrated that an MEF2 binding site within this region was necessary, but not sufficient, for GLUT4 promoter function in transgenic mice. We have identified a second regulatory element (Domain I) that functions cooperatively with the MEF2 domain in regulating GLUT4 transcription. Using a yeast-one hybrid screen, we obtained a partial cDNA and generated an antibody directed against a protein binding specifically to Domain I. Sequence analysis of the partial cDNA indicates that the protein binding to Domain I is a novel protein. The antibody specifically labels two proteins of approximately 70 and 50 kDa in Western blot analysis. These molecular masses correspond to Domain I binding proteins identified by UV-cross-linking nuclear extracts to a Domain I probe. The antibody raised against the Domain I binding protein inhibited formation of a Domain I-protein complex in electrophoretic mobility shift assays. We conclude that we have identified an authentic, novel, Domain I binding protein required for transcriptional regulation of the human GLUT4 promoter.
A critical analysis of undergraduate students' cultural immersion experiences.

PURPOSE This paper is concerned with the impact of an international health promotion experience on the understanding of culture among university students. Such immersion experiences are often cited as a strategy to prepare nurses for culturally appropriate practice. We describe students' epistemic movements over time with respect to cultural perspectives prior to, during and after a field study in Malawi. DESIGN Data were collected at three time points from students in undergraduate nursing (n = 14) and non-nursing (n = 8) programs at a Canadian university. Two essays narrating participants' understanding of culture were submitted by consenting class members. A subgroup of nine participants (four nursing students, five from other disciplines) completed a third narrative following a subsequent field study course in Malawi. METHOD Using narrative analysis, themes and structures in the participants' writing were identified and located within a constructivist or essentialist paradigm of cultural understanding. FINDINGS Overwhelmingly, students' narratives were initially portrayed and informed by an essentialist understanding of culture. Later narratives demonstrated varying degrees of epistemic movement towards more constructivist viewpoints. Narratives that initially exhibited constructivist characteristics tended to display strengthened convictions in that paradigm. CONCLUSION We challenge the claim that an international immersion experience immediately transforms participants into cultural experts; our evidence suggests that students experienced existential growth, but their understanding of culture did not change as a result of their brief stay in a different cultural context. Cultural immersion is a phenomenon that requires more critical analysis and systematic investigation to determine how such experiences contribute to learning about culture among nursing students.
Angular Pattern and Binary Angular Pattern for Shape Retrieval

In this paper, we propose two novel shape descriptors, angular pattern (AP) and binary angular pattern (BAP), and a multiscale integration of them for shape retrieval. Both AP and BAP are intrinsically invariant to scale and rotation. More importantly, being global shape descriptors, the proposed shape descriptors are computationally very efficient, while possessing similar discriminability as state-of-the-art local descriptors. As a result, the proposed approach is attractive for real world shape retrieval applications. The experiments on the widely used MPEG-7 and TARI-1000 data sets demonstrate the effectiveness of the proposed method in comparison with existing methods.
Impulsivity and the Self-Defeating Behavior of Narcissists

Currently prominent models of narcissism (e.g., Morf & Rhodewalt, 2001) primarily explain narcissists' self-defeating behaviors in terms of conscious cognitive and affective processes. We propose that the disposition of impulsivity may also play an important role. We offer 2 forms of evidence. First, we present a meta-analysis demonstrating a strong positive relationship between narcissism and impulsivity. Second, we review and reinterpret the literature on 3 hallmarks of narcissism: self-enhancement, aggression, and negative long-term outcomes. Our reinterpretation argues that impulsivity provides a more parsimonious explanation for at least some of narcissists' self-defeating behavior than do existing models. These 2 sources of evidence suggest that narcissists' quest for the status and recognition they so intensely desire is thwarted, in part, by their lack of the self-control necessary to achieve those goals.