Miracle-dz/UniFAR-FTUs huggingface dataset:
New Procedures to Assess Executive Functions in Preschool Children*

Executive functions are difficult to assess in preschool children, yet the preschool period is particularly important, both in the development of behavioral control and of the brain, particularly the prefrontal cortex. Several tasks were adapted from developmental and neuroscience literature and then administered to 98 preschool children (30-, 36-, 42-, 48- and 60-month age groups). Executive function task performance was related largely to age group, but not to sex or intelligence. These tasks, then, were sensitive in this age range and may be useful to delineate distinct cognitive profiles among preschool children with various neurological and developmental disorders.
Autobiographical Memory in Patients with Tinnitus

Studies on psychiatric patients have found that their memories of the past are often unspecific and overgeneral, but the extent to which this is the case for patients with somatic problems has so far only been examined in patients with chronic pain and in patients with diabetes. The present study investigated autobiographical memories in 19 tinnitus patients and 19 controls without tinnitus. Participants were administered the autobiographical memory test (AMT), the Controlled word association test, and self-report measures of depression, anxiety, and tinnitus distress. Compared to control participants, tinnitus patients had difficulty retrieving specific memories and showed longer retrieval latencies. Additionally, tinnitus patients had fewer specific memories to positive cue words. While AMT responses were associated with depression scores, the difference between controls and patients remained significant for positive cue words after controlling for depression scores. Results suggest that cognitive components should be an integral element of the psychological management of tinnitus. The use in future studies of experimental methods such as AMT in health psychology is encouraged.
Student Employment and Higher Education: Empiricism and Contradiction

College student employment has been increasing steadily for at least four decades. At present, approximately 80% of all college students are employed while completing their undergraduate education. Even among students under the age of 24 at 4-year colleges, more than 50% are employed during the school year. Although some general trends are suggested by empirical research completed to date, studies that evaluate student employment and higher education are at times inconsistent and even contradictory. Despite the high prevalence of student employment, no theoretical models have been developed to explain the relationship between employment and student outcomes. This article briefly reviews the student employment–higher education empirical literature. Possible reasons for inconsistencies are suggested, including challenges posed by methodological issues and the absence of theoretical conceptualization. Some concluding suggestions are offered for addressing these empirical challenges.
Continuing Motivation: An Analysis of a Seldom Considered Educational Outcome

One of the more important-but seldom studied-educational outcomes is, what might be termed, continuing motivation. Briefly put, continuing motivation is defined as the tendency to return to and continue working on tasks away from the instructional context in which they were initially confronted. This return is presumably occasioned by a continuing interest in the task and not by external pressure of some kind. Thus, the kindergarten child spends the evening reliving or redoing many of the day's events. Nursery rhymes are repeated again, again-and again! The same figures are redrawn and siblings are coerced to "play school. " And, occasionally the 10-year-old will check out a book on Indians after a social studies unit, consult the family library about a point raised in a class discussion, or proceed to turn the family kitchen into a chemistry lab-all without any direct or noticeable pressure from school, teacher, or parent. Something has happened, possibly in the course of the school day, to create a continuing interest in a given activity. The student has been "turned on" to seek out learning and educational experiences outside the classroom. "Continuing motivation" has been created! Seldom, if ever, has educational research focused on such
The “repertoire”; of information sources

“Information source”; studies presumed that media exposure led to different attitudes and behaviors. Recent research suggests that motivations and interests lead to the selection of a set of information sources. Using ten topics this study focused on the relation of the interest people had in these topics and the sources they selected for information about the topics. As interest in a topic increased so did the number of sources, and as interest changed so did the information “repertoire. ”
Galanin overexpressing transgenic mice

Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT). Performance deficits on learning and memory tasks, impaired long-term potentiation, reduced hippocampal excitability, lower evoked glutamate release, and reduced numbers of choline acetyltransferase immunoreactive neurons in the horizontal limb of the diagonal band were detected in GAL-tg as compared to WT. Changes in sensitivity to nociceptive stimuli were demonstrated in one line. GAL-tg represent a new model for investigating the biological actions of endogenous galanin, and for testing novel therapeutics based on galanin receptor ligands.
Stylometry System - Use Cases and Feasibility Study

Stylometry is a discipline that determines authorship of literary works through the use of statistical analysis and machine learning. While this discipline has been used successfully to determine authorship of famous literary works, the area of analyzing digital content is still relatively new with much more to discover. Since the early to mid 1990’s the explosion of the Internet has opened up new uses for stylometry in the area of email, social networking, and various types of digital content. This paper is divided into two parts. Part I discusses potential uses of stylometry in the area of Internet content and presents four use cases in areas that have had little or no research. Part II evaluates three existing stylometry tools and conducts a feasibility study to determine if the tools can correctly assign authorship of electronic mail to its original author.
Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis

Background Chronic pain is highly prevalent and a significant source of disability, yet its genetic and environmental risk factors are poorly understood. Its relationship with major depressive disorder (MDD) is of particular importance. We sought to test the contribution of genetic factors and shared and unique environment to risk of chronic pain and its correlation with MDD in Generation Scotland: Scottish Family Health Study (GS:SFHS). We then sought to replicate any significant findings in the United Kingdom Biobank study. Methods and Findings Using family-based mixed-model analyses, we examined the contribution of genetics and shared family environment to chronic pain by spouse, sibling, and household relationships. These analyses were conducted in GS:SFHS (n = 23,960), a family- and population-based study of individuals recruited from the Scottish population through their general practitioners. We then examined and partitioned the correlation between chronic pain and MDD and estimated the contribution of genetic factors and shared environment in GS:SFHS. Finally, we used data from two independent genome-wide association studies to test whether chronic pain has a polygenic architecture and examine whether genomic risk of psychiatric disorder predicted chronic pain and whether genomic risk of chronic pain predicted MDD. These analyses were conducted in GS:SFHS and repeated in UK Biobank, a study of 500,000 from the UK population, of whom 112,151 had genotyping and phenotypic data. Chronic pain is a moderately heritable trait (heritability = 38.4%, 95% CI 33.6% to 43.9%) that is significantly concordant in spouses (variance explained 18.7%, 95% CI 9.5% to 25.1%). Chronic pain is positively correlated with depression (ρ = 0.13, 95% CI 0.11 to 0.15, p = 2.72x10-68) and shows a tendency to cluster within families for genetic reasons (genetic correlation = 0.51, 95%CI 0.40 to 0.62, p = 8.24x10-19). Polygenic risk profiles for pain, generated using independent GWAS data, were associated with chronic pain in both GS:SFHS (maximum β = 6.18x10-2, 95% CI 2.84 x10-2 to 9.35 x10-2, p = 4.3x10-4) and UK Biobank (maximum β = 5.68 x 10−2, 95% CI 4.70x10-2 to 6.65x10-2 , p < 3x10-4). Genomic risk of MDD is also significantly associated with chronic pain in both GS:SFHS (maximum β = 6.62x10-2, 95% CI 2.82 x10-2 to 9.76 x10-2 , p = 4.3x10-4) and UK Biobank (maximum β = 2.56x10-2, 95% CI 1.62x10-2 to 3.63x10-2 , p < 3x10-4). Limitations of the current study include the possibility that spouse effects may be due to assortative mating and the relatively small polygenic risk score effect sizes. Conclusions Genetic factors, as well as chronic pain in a partner or spouse, contribute substantially to the risk of chronic pain for an individual. Chronic pain is genetically correlated with MDD, has a polygenic architecture, and is associated with polygenic risk of MDD.
Biosecurity Implications of New Technology and Discovery in Plant Virus Research

Human activity is causing new encounters between viruses and plants. Anthropogenic interventions include changing land use, decreasing biodiversity, trade, the introduction of new plant and vector species to native landscapes, and changing atmospheric and climatic conditions. The discovery of thousands of new viruses, especially those associated with healthy-appearing native plants, is shifting the paradigm for their role within the ecosystem from foe to friend. The cost of new plant virus incursions can be high and result in the loss of trade and/or production for short or extended periods. We present and justify three recommendations for plant biosecurity to improve communication about plant viruses, assist with the identification of viruses and their impacts, and protect the high economic, social, environmental, and cultural value of our respective nations' unique flora: 1) As part of the burden of proof, countries and jurisdictions should identify what pests already exist in, and which pests pose a risk to, their native flora; 2) Plant virus sequences not associated with a recognized virus infection are designated as “uncultured virus” and tentatively named using the host plant species of greatest known prevalence, the word “virus,” a general location identifier, and a serial number; and 3) Invest in basic research to determine the ecology of known and new viruses with existing and potential new plant hosts and vectors and develop host-virus pathogenicity prediction tools. These recommendations have implications for researchers, risk analysts, biosecurity authorities, and policy makers at both a national and an international level.
Framing, Agenda Setting, and Priming: The Evolution of Three Media Effects Models

This special issue of Journal of Communication is devoted to theoretical explanations of news framing, agenda setting, and priming effects. It examines if and how the three models are related and what potential relationships between them tell theorists and researchers about the effects of mass media. As an introduction to this effort, this essay provides a very brief review of the three effects and their roots in media-effects research. Based on this overview, we highlight a few key dimensions along which one can compare, framing, agenda setting, and priming. We conclude with a description of the contexts within which the three models operate, and the broader implications that these conceptual distinctions have for the growth of our discipline. doi:10.1111/j.1460-2466.2006. 00326.x In 1997, Republican pollster Frank Luntz sent out a 222-page memo called ‘‘Language of the 21st century’’ to select members of the U.S. Congress. Parts of the memo soon spread among staffers, members of Congress, and also journalists. Luntz’s message was simple: ‘‘It’s not what you say, it’s how you say it’’ (Luntz, in press). Drawing on various techniques for real-time message testing and focus grouping, Frank Luntz had researched Republican campaign messages and distilled terms and phrases that resonated with specific interpretive schemas among audiences and therefore helped shift people’s attitudes. In other words, the effect of the messages was not a function of content differences but of differences in the modes of presentation. The ideas outlined in the memo were hardly new, of course, and drew on decades of existing research in sociology (Goffman, 1974), economics (Kahneman & Tversky, 1979), psychology (Kahneman & Tversky, 1984), cognitive linguistics (Lakoff, 2004), and communication (Entman, 1991; Iyengar, 1991). But Frank Luntz was the first professional pollster to systematically use the concept of framing as a campaign tool. The Democratic Party soon followed and George Lakoff published Don’t Think of an
Learning From the Birmingham Civil Rights Institute: Documenting Teacher Development

This study explores the extent to which experiences designed to help preservice teachers take advantage of the Birmingham Civil Rights Institute moved them to acquire deeper knowledge of the Civil Rights Movement. The pre-service teachers came from two teacher education programs that differ with respect to situated activity, discourse communities, and authentic practice. Before and after a visiting the museum, undergraduate preservice teachers (n = 49) created concept maps, or “webs,” of the Civil Rights Movement, responded to discussion prompts in small groups, and prepared field-trip activities and follow-up lessons. Analyses of the webs, conversations, activities, and lesson plans revealed that all students gained a considerable amount of information, appreciation, and understanding. Differences in the two groups support the idea of teacher education frameworks that build from the “community of learners” model.
The diagnosis of partial growth hormone deficiency in adults with a putative insult to the hypothalamo-pituitary axis.

CONTEXT Similar to patients with severe GH deficiency (GHD), those with a more moderate impairment of GH secretion [GH insufficiency (GHI)] have abnormal body composition, dyslipidemia, and insulin resistance. Given the inherent problems in the diagnosis of severe GHD, the situation is likely to be even more difficult in individuals with GHI. OBJECTIVE The objective of the study was to examine the utility of GH stimulation tests and GH-dependent proteins in the diagnosis of GHI. DESIGN The study was a cross-sectional, case-controlled study. PATIENTS The study included 31 patients with GHD, 23 with GHI [peak GH 3-7 microg/liter (9-21 mU/liter)], and 30 age- and sex-matched controls. MAIN OUTCOME MEASURES Demographic and biochemical markers of GH status were measured. RESULTS Nineteen of the patients with GHI (83%) had no additional anterior pituitary hormone deficits. Ten GHI patients showed discordant GH status based on the two GH stimulation tests performed. GH status was defined by the highest peak GH value achieved; in four this was to the insulin tolerance test (ITT), four the arginine test, and two the GHRH-arginine test. In five of the six patients in whom GH status was not defined by the ITT, peak GH levels to the ITT were in the range 2.4-2.9 microg/liter. IGF-I values for the GHI adults were significantly lower than the control subjects (121 +/- 48 vs. 162 +/- 75 microg/liter; P < 0.05); however, only six (26%) had values below the 10th percentile of levels seen in the control group. IGF binding protein-3 and acid labile subunit levels of the GHI adults were not significantly different from the controls. CONCLUSION The diagnosis of GHI in an individual is extremely difficult because the patients rarely exhibit additional pituitary hormone deficits, and levels of GH-dependent proteins are normal in the majority. Diagnosis relies heavily on GH stimulation tests and requires two tests in all patients to define GHI; obesity when present is potentially a major confounder.
From risk to resilience

This article considers the rise of therapeutic education in Finland, a phenomenon already acknowledged in Europe, Canada and the United States. In Finland, the therapeutic ethos has been assimilated into educational policies and practices, but the shift to therapisation and especially its consequences have attracted little interest in critical educational research. This article is based on a Foucauldian discourse-analytic methodology and on a previous empirical study. It emphasises the effects of therapeutic interventions in education and focuses on project-based educational practices that deal with young adults who are on the margins of society. The central argument is that therapeutic interventions force young adults to focus more on themselves and lead to an internalisation of the idea that societal problems such as unemployment, a lack of education or criminal behaviour are in fact individual-based.
Kisspeptin regulates steroidogenesis and spermiation in anuran amphibian.

Kisspeptin (Kp) system has a recognized role in the control of gonadotropic axis, at multiple levels. Recently, a major focus of research has been to assess any direct activity of this system on testis physiology. Using the amphibian anuran, Pelophylax esculentus, as animal model, we demonstrate - for the first time in non-mammalian vertebrate - that testis expresses both Kiss-1 and Gpr54 proteins during the annual sexual cycle and that ex vivo 17B-estradiol (E2, 10-6 M) increases both proteins over control group. Since the interstitium is the main site of localization of both ligand and receptor, its possible involvement in the regulation of steroidogenesis has been evaluated by ex vivo treatment of testis pieces with increasing doses of Kp-10 (10-9-10-6 M). Treatments have been carried out in February - when a new wave of spermatogenesis occurs - and affect the expression of key enzymes of steroidogenesis inducing opposite effects on testosterone and estradiol intratesticular levels. Morphological analysis of Kp-treated testes reveals higher number of tubules with spermatozoa detached from Sertoli cells than control group and the expression of connexin 43, the main junctional protein in testis, is deeply affected by the treatment. In spite of the effects on spermatozoa observed ex vivo, in vivo administration of Kp-10 has been unable to induce sperm release in cloacal fluid. In conclusion, we demonstrate Kp-10 effects on steroidogenesis with possible involvement in the balance between testosterone and estradiol levels, and report new Kp-10 activities on spermatozoa-Sertoli cell interaction.
Quality of Extracranial Carotid Evaluation with 256-Section CT

BACKGROUND AND PURPOSE: To date, no systematic evaluation of image quality has been performed on the 256-section multidetector CT scanner for extracranial carotid evaluations. We evaluated image quality, patient dose, and examination time and compared these parameters with a 64-section multidetector CT. MATERIALS AND METHODS: We reviewed extracranial CTA scans obtained on a 256-detector CT scanner in 50 consecutive patients. Image quality was analyzed for artifacts and vessel contrast opacification from the aortic arch to the skull base, dose to patient, and scan time. Results were compared with a control group of 50 patients imaged on a 64-section CT scanner. A Fisher exact test was used to analyze both groups with respect to vessel contrast opacification and presence of artifacts, and a Student t test was used to assess differences in patient dose between the 2 groups. RESULTS: Quantitative and qualitative evaluations revealed >95% acceptable vessel opacification at all levels measured on the 256-section scanner. Scan time was improved (4 seconds on 256-channel). There were fewer artifacts related to metallic streak on the 256-channel CTA study, and DLP was lower on the 256-channel CTA (113.9 versus 159.8 mGy). CONCLUSIONS: The 256-channel CTA imaging protocol for carotid arteries yielded similar vessel contrast opacification compared with the 64-channel CTA but with fewer metallic artifacts, a modest decrease in scan time, similar image quality, and a statistically significant reduction in radiation dose of 10%.
More on James and the Physical Basis of Emotion

We first present a reconstruction of James’s theory of emotion (JATE) and then argue for four theses: (a) Despite constructivist elements, James’s views are overall in line with basic emotions theory. (b) JATE does not exclude an influence of emotion on intentional action even in its original formulation; nevertheless, this influence is quite limited. It seems possible, however, to repair this problem of the theory. (c) Cannon’s theory of emotion is a centralized version of JATE that inherits from the latter theory a potentially fatal flaw, the insufficient physiological differentiation of emotions. (d) The core claim of JATE, that emotions are bodily feelings, is very likely false.
Role ambiguity and volunteer board member performance in nonprofit sport organizations

We explore the relationship between multidimensional role ambiguity and individual board member performance within nonprofit voluntary sport organizations. Role ambiguity accounted for 29 percent of the variance in perceived board member performance, and ambiguity about one's responsibilities was the strongest predictor. These findings extend our understanding of the drivers of individual board member performance within voluntary sport organizations and the multidimensional nature of role ambiguity. The study supports previous arguments that knowing what to do is fundamental to one's performance, and more critical than knowing how to do it, and what difference it makes.
Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells.

Ribosomal S6 kinases (RSKs) are directly regulated by extracellular signal-regulated kinase (ERK) signaling and are implicated in cell growth, survival, motility and senescence. The present study observed that RSK1 was overexpressed in primary untreated leukemia patient bone marrow samples compared with the expression at the complete remission stage, using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In addition, a high RSK1 expression (relative expression ≥10) was associated with a significantly shorter overall survival (P=0.038) compared with that in patients with low RSK1 expression (relative expression <10). The current study also investigated the effect of luteolin, a novel p90 ribosomal S6 kinase (RSK) inhibitor extracted from Reseda odorata L. , which shows strong biochemical functions including anti-allergy, anti-inflammation and anti-cancer functions, in MOLM-13 and Kasumi-1 leukemic cells. The cell viability, apoptosis and migration ability analysis were assessed by performing a cell counting kit-8 assay, Annexin V-FITC/PI double staining and migration filter assay, respectively. The results indicated that luteolin inhibited the growth of the leukemic cell lines through induction of apoptosis, while the migration ability was also suppressed. Overexpression of RSK1 by plasmid transfection was found to decrease the luteolin-induced apoptosis and migration capabilities. By contrast, knockdown of the RSK1 expression by small interfering RNA appeared to induce the same effect as luteolin on MOLM-13 and Kasumi-1 leukemic cells. In conclusion, these results suggest that luteolin inhibits leukemic cell proliferation and induces apoptosis by inhibition of the RSK1 pathways.