Miracle-dz/UniFAR-FTUs huggingface dataset:
Coexisting Mantle Cell Lymphoma and Prostate Adenocarcinoma

Prostatic mantle cell lymphoma (MCL) is a very rare entity with only 5 reported cases in the literature. We report a case of coexisting MCL and prostate adenocarcinoma (PCa) in an elderly male and review the morphologic features of classic and rare prostatic MCL subtypes. Careful morphologic evaluation and immunohistochemical findings of positive CD5, CD20, and cyclin D1 and negative CD23 and CD3 can guide us to the diagnosis of MCL. Given the fact that transurethral resection of prostate is done quite routinely, this paper draws attention to the manner in which long standing bladder outlet obstruction and postbiopsy prostate specimens with dense lymphoid infiltration can masquerade as lymphoma. It highlights the importance of exercising care while reviewing prostate specimens with evidence of chronic prostatitis so as not to miss this rare neoplasm.
Why Does Higher Variability of Trading Activity Predict Lower Expected Returns?

The paper shows that controlling for the aggregate volatility risk factor eliminates the puzzling negative relation between variability of trading activity and future abnormal returns. I find that variability of other measures of liquidity and liquidity risk is largely unrelated to expected returns. Lastly, I show that the low returns to firms with high variability of trading activity are not explained by liquidity risk or mispricing theories.
Urine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study

OBJECTIVE The predictive value of microalbuminuria (MAU) for kidney damage is limited in type 2 diabetes (T2D). We studied whether a urine proteome specific for sight-threatening proliferative diabetic retinopathy (PDR) is an indicator to predict chronic renal insufficiency (CRI) in patients with T2D. RESEARCH DESIGN AND METHODS A shotgun urine proteomic analysis was performed in patients with MAU and PDR (case subjects) and in patients with MAU and a duration of T2D for >10 years but without any degree of retinopathy (control subjects). In the cohort study, 210 patients with T2D with an estimated glomerular filtration rate (eGFR) ≥80 mL/min/1.73 m2 were followed for a median of 5.3 years. Urine proteins specific for PDR were used for predicting CRI (eGFR <60 mL/min/1.73 m2). RESULTS The top two urine proteins with the highest difference in ratio of case subjects to control subjects were haptoglobin (8.7 times; P < 0.0001) and α-2-macroglobulin (5.7 times; P < 0.0001). In the cohort study, patients with baseline urinary haptoglobin ≥20 ng/min (haptoglobinuria) had a higher incidence of CRI than those without (hazard ratio [95% CI] 3.27 [1.41–7.58]; P = 0.006). The overall CRI rate was 3.2% for patients without haptoglobinuria or MAU, 9.5% for those with MAU, and 13.3% for those with haptoglobinuria. The highest rate for CRI (22.4%) was in patients with both MAU and haptoglobinuria (P < 0.001). CONCLUSIONS Urine haptoglobin, which is specific for PDR, is a novel biomarker and complement to urine albumin for predicting kidney damage in patients with T2D.
Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties

White adipose tissue (WAT) is a complex organ with both metabolic and endocrine functions. Dysregulation of all of these functions of WAT, together with low-grade inflammation of the tissue in obese individuals, contributes to the development of insulin resistance and type 2 diabetes. n-3 polyunsaturated fatty acids (PUFAs) of marine origin play an important role in the resolution of inflammation and exert beneficial metabolic effects. Using experiments in mice and overweight/obese patients with type 2 diabetes, we elucidated the structures of novel members of fatty acid esters of hydroxy fatty acids—lipokines derived from docosahexaenoic acid (DHA) and linoleic acid, which were present in serum and WAT after n-3 PUFA supplementation. These compounds contained DHA esterified to 9- and 13-hydroxyoctadecadienoic acid (HLA) or 14-hydroxydocosahexaenoic acid (HDHA), termed 9-DHAHLA, 13-DHAHLA, and 14-DHAHDHA, and were synthesized by adipocytes at concentrations comparable to those of protectins and resolvins derived from DHA in WAT. 13-DHAHLA exerted anti-inflammatory and proresolving properties while reducing macrophage activation by lipopolysaccharides and enhancing the phagocytosis of zymosan particles. Our results document the existence of novel lipid mediators, which are involved in the beneficial anti-inflammatory effects attributed to n-3 PUFAs, in both mice and humans.
RAS-NANO: A Reliability-Aware Synthesis Framework for Reconfigurable Nanofabrics

Entering the nanometer era, a major challenge to current design methodologies and tools is to effectively address the high defect densities projected for nanotechnologies. To this end, we proposed a reconfiguration-based defect-avoidance methodology for defect-prone nanofabrics. It judiciously architects the nanofabric, using probabilistic considerations, such that a very large number of alternative implementations can be mapped into it, enabling defects to be circumvented at configuration time in a scalable way. Building on this foundation, in this paper we propose a synthesis framework aimed at implementing this new design paradigm. A key novelty of our approach with respect to traditional high level synthesis is that, rather than carefully optimizing a single (`deterministic') solution, our goal is to simultaneously synthesize a large family of alternative solutions, so as to meet the required probability of successful configuration, or yield, while maximizing the family's average performance. Experimental results generated for a set of representative benchmark kernels, assuming different defect regimes and target yields, empirically show that our proposed algorithms can effectively explore the complex probabilistic design space associated with this new class of high level synthesis problems
Research on short-term load forecasting based on adaptive hybrid genetic optimization BP neural network algorithm

Short-term load forecasting may impact the plan of the production of the electricity system and the arrangement of the power system short-term operation mode, and it has great economic significance. Some scholars used BP neural network to forecast the short-term load, and they found it has the intrinsic defects. Itpsilas difficult to determine the network structure and it easily run into partial minimum points. Based on genetic algorithmpsilas strong global searching ability and BP neural networkpsilas accurate local searching ability, this paper proposes an adaptive hybrid genetic BP neural network algorithm. It uses genetic algorithm to optimize the BP network initial weight first, then uses the BP neural network to learn by itself according to the data given, to acquire an excellent load forecasting system. In the training of neural network, the over-fitting often appears which affects the result of forecasting. To prevent this problem, the entire data set is divided into training set and validation set randomly. This algorithm was used to predict the load of Sydney. Simulation results indicate that the algorithm improves the forecast accuracy and the performance of the network.
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells

Members of the Runx family of transcriptional regulators are required for the appropriate expression of CD4 and CD8 at discrete stages of T cell development. The roles of these factors in other aspects of T cell development are unknown. We used a strategy to conditionally inactivate the genes encoding Runx1 or Runx3 at different stages of thymocyte development, demonstrating that Runx1 regulates the transitions of developing thymocytes from the CD4(-)CD8(-) double-negative stage to the CD4(+)CD8(+) double-positive (DP) stage and from the DP stage to the mature single-positive stage. Runx1 and Runx3 deficiencies caused marked reductions in mature thymocytes and T cells of the CD4(+) helper and CD8(+) cytotoxic T cell lineages, respectively. Runx1-deficient CD4(+) T cells had markedly reduced expression of the interleukin 7 receptor and exhibited shorter survival. In addition, inactivation of both Runx1 and Runx3 at the DP stages resulted in a severe block in development of CD8(+) mature thymocytes. These results indicate that Runx proteins have important roles at multiple stages of T cell development and in the homeostasis of mature T cells.
Do the hands have it? The facilitation effects of arm and hand gesture on word retrieval in aphasia

Background: There is considerable disagreement in the literature concerning the function of co‐verbal gesture. Studies of the relationship between speech and gesture have employed an array of methods to investigate the origin and functions of arm and hand gesture. Commonly, these studies have utilised an experimental design to examine possible speech facilitation effects. However there is a need to examine spontaneous gesture production and its effect on speech production, as evidence suggests that natural gesture production is distinct from that produced under test conditions. Aims: To investigate the possible facilitation effects of spontaneously generated arm and hand gestures during word retrieval difficulty in people with aphasia. Methods & Procedures: Conversational samples 20 minutes long were acquired from 18 participants with chronic aphasia. Verbal utterances were transcribed for word retrieval difficulty, resolved word retrieval difficulty, and fluent speech production. The transcription was augmented with all arm and hand gestures produced by the participants. Gestures were segmented into gesture units and classified into types. A second rater classified 20% of the samples for gesture type, occurrence of word retrieval difficulty, and whether the difficulty was successfully resolved or not. Consensus ratings were carried out where disagreement occurred. Variables were paired for comparison using a series of non‐parametric Wilcoxon Signed‐Ranks Tests. Outcomes & Results: Gesture production was significantly higher during instances of word retrieval difficulties. The resolution of word retrieval difficulty was significantly more frequent with a gesture present. Crucially, there was no significant difference between the amounts of gesture produced during resolved, as compared to unresolved, word retrieval difficulties. However performance in the group was variable. Five individuals produced over 50% more gesture during resolved word retrieval events than during unresolved. Post‐hoc examination of the linguistic characteristics of these five participants suggested they had a specific phonological level impairment. Conclusions: Gesture production is multifunctional for people with aphasia. People with mild aphasia, who have the majority of their linguistic resources still accessible, are likely to experience facilitation from gesture production, and hence gesture treatment maybe an appropriate and potent therapy focus. Some individuals with severe language impairment are capable of using many rich, communicative gestures. Such gesture expression should be explored as a viable component of a “total communication” therapeutic approach for those individuals.
Comparison of population based cancer incidence rates among Circassians, Chechans and Arabs in Jordan (1996-2005).

BACKGROUND Cancer is a complex disease caused by multiple factors, both genetic and environmental. It is a major health concern worldwide, in the Middle East and in Jordan specifically and the fourth most common killer in the Middle East. HYPOTHESIS The relative genetic homogeneity of the Circassian and Chechan populations in Jordan results in incidences of cancer that differ from the general Jordanian population, who are mostly Arabs. MATERIALS AND METHODS National Cancer Registry data were obtained for the years 1996-2005 The Chechen and Circassian cancer cases were identified and cancer registry data were divided into three populations. Crude rates were calculated based on the number of cancer cases and estimated populations. RESULTS Breast cancer is the most common cancer type constituting about one third of female cancers in all three populations. Higher crude rates are observed in the Circassian and Chechen populations than in the Arab Jordanian population. The rate ratios (95%CI) in Circassians and Chechens with respect to the Arab Jordanian population are 2.1 (1.48, 2.72) and 1.81 (1.16, 2.85), respectively. Lung cancer is the most common cancer in male Arab Jordanians and Chechens with crude rates of 4.2 and 8.0 per 100,000 respectively. The male to female ratio in these two populations in respective order are 5:1 and 7:1. The lung cancer crude rate in Circassians is 6.5 per 100,000 with a male to female ratio of only 1.6:1. The colorectal cancer crude rates in Arab Jordanians and Chechens are similar at 6.2 and 6.0 per 100,000, respectively, while that in Circassians is twice as high. CONCLUSIONS Considerable ethnic variation exists for cancer incidence rates in Jordan. The included inbred and selected populations offer an ideal situation for investigating genetic factors involved in various cancer types.
Validation of the multicultural personality questionnaire in the context of personnel selection

The present data provide support for the reliability of the Multicultural Personality Questionnaire among a sample of job applicants (n=264). Factor analysis confirmed five factors: Cultural Empathy, Open‐Mindedness, Social Initiative, Flexibility, and Emotional Stability. Moreover, the data largely support the construct validity of the MPQ. Correlations with the Big Five were in the expected direction, and as predicted, Cultural Empathy and Social Initiative were both positively related to socially oriented vocational interests and Flexibility to artistic interests. Against our predictions, Cultural Empathy, Open‐Mindedness, and Flexibility appeared to be related to verbal intelligence. A comparable pattern of relations of the Big Five with intelligence and vocational interests was found. Finally, the MPQ scales predicted variance in an indicator of overall behaviour above the Big Five, supporting its incremental validity. Copyright © 2003 John Wiley & Sons, Ltd.
Hepatocellular Carcinoma More Than 3 cm in Diameter: A Systematic Review of Transcatheter Arterial Chemoembolization Plus Percutaneous Ethanol Injection versus Transcatheter Arterial Chemoembolization Alone

Objective. To identify the efficiency and safety of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol (PEI) for patients with hepatocellular carcinoma (HCC) more than 3 cm in diameter in comparison with those of transcatheter arterial chemoembolization monotherapy. Methods. All databases were searched up to February 22, 2013. The literature retrieval was conducted through Pubmed, Web of Science, and Cochrane Library. We also searched Chinese databases, including Chinese National Knowledge Infrastructure (CNKI), Chinese Biology Medicine (CBM), Wanfang database, and VIP Database for Chinese Technical Periodicals without language limitations. Results. Based on the criteria, we found 12 RCTs including 825 patients. Our results showed that TACE combined with PEI therapy compared with TACE monotherapy improved overall survival and tumor response. Conclusion. The combination of TACE and PEI compared with TACE monotherapy improved overall survival rates and tumor response of patients with large HCC. Besides, larger and more methodologically rigorous clinical trials are needed to confirm this outcome.
Role of Glycolytic Products in Damage to Ischemic Myocardium: Dissociation of Adenosine Triphosphate Levels and Recovery of Function of Reperfused Ischemic Hearts

The mechanism of irreversible damage to ischemic myocardium was investigated in the perfused rat heart. The time of transition from reversible to irreversible damage to contractile function was accelerated by accumulation of glycolytic products and increases in extracellular calcium. Both of these effects were largely independent of adenine nucleotide levels in the tissue. With zero coronary flow and 1.25 nut calcium the decrease in ability of the heart to recover ventricular function with reperfusion after 30 minutes of ischemia was directly correlated with accumulation of glycolytic products (as estimated by tissue lactate) during ischemia. The extent of lactate accumulation during ischemia was varied by preperfusing the hearts for 0, 10, or 15 minutes under anoxic, high coronary flow conditions to deplete tissue glycogen prior to ischemia, and by adding lactate back to the perfusate of these hearts during the ischemic period. Recovery of ventricular function was inversely related to tissue lactate during ischemia and varied from 28 to 92percent;, even though there was little or no change in tissue levels of residual adenosine triphosphate. Increasing extracellular calcium accelerated the time of onset of irreversible damage with little or no change in residual adenosine triphosphate levels. At any given calcium concentration, the time-dependent declines in the ability of the heart to recover ventricular function was also largely independent of adenosine triphosphate levels. These studies suggest a major role of anaerobic glycolytic products (lactate, hydrogen ion, or NADH) in ischemic damage to the heart that is unrelated to loss of tissue adenine nucleotides. With zero or low flow ischemia, this effect may result in irreversible damage to the myocardium before adenine nucleotides are reduced to critically low levels.
The Waning Effect of Sibship Composition on School Attainment in Hong Kong

L'organisation familiale traditionnelle a Hong Kong favorisait l'education des garcons au detriment de celle des filles. Cet article, a partir d'une comparaison de donnees recueillies en 1981 et 1991, examine l'effet des politiques publiques sur l'egalite des chances dans le milieu familial ; les effets sur les resultats scolaires de la taille de la fratrie, de la repartition fille-garcon et du rang de naissance sont pris en compte afin de mettre en evidence la sociologie de la culture et de l'economie familiales a hong Kong. Le niveau d'education des meres ainsi que la presence de soeurs plus âgees influent sur l'egalite des sexes mais le niveau de revenu de la famille influe plus encore sur l'inegalite et le retrait du soutien economique de l'Etat renforce cette inegalite.
Spastin mutations in sporadic adult‐onset upper motor neuron syndromes

Mutation of the spastin gene is the single most common cause of pure hereditary spastic paraparesis. In patients with an unexplained sporadic upper motor neuron (UMN) syndrome, clinical distinction between primary lateral sclerosis and sporadic hereditary spastic paraparesis may be problematic. To investigate whether spastin mutations are present in patients with primary lateral sclerosis and sporadic hereditary spastic paraparesis, we screened the spastin gene in 99 Dutch patients with an unexplained, apparently sporadic, adult‐onset UMN syndrome. We found 6 mutations, of which 4 were novel, in the subgroup of 47 patients with UMN symptoms restricted to the legs (13%). Another novel spastin mutation was found in a patient with a rapidly progressive spinal and bulbar UMN syndrome that progressed to amyotrophic lateral sclerosis. In the patients with arm or bulbar UMN symptoms and slow progression, no spastin mutations were found. Our study shows that spastin mutations are a frequent cause of apparently sporadic spastic paraparesis but not of primary lateral sclerosis. Ann Neurol 2005
Beyond human resource management in co‐operatives

Purpose – This paper seeks to critically review developments in the literature spanning personnel management, HRM, learning organization and intellectual capital approaches to employee utilization and development. The purpose being to identify the benefits, limitations and lessons for the management of people in the co‐operative and mutual sectors.Design/methodology/approach – The problem of inadequate Personnel or HRM systems in the majority of co‐operatives has been established by the author over a period of seven years, field work with co‐operative organizations including the international co‐operative alliance (ICA), asian confederation of credit unions (ACCU), and the British society for co‐operative studies. Direct interviews and a sample of HRM and Membership Relations audit forms developed as part of the ongoing field research and special project work have been applied to various co‐operative contexts in all the regions of the ICA.Findings – The findings are that co‐operatives generally are laggin.
Dynamic situation and threat assessment for collision warning systems: the EUCLIDE approach

Situation and threat assessment is considered as the highest level of abstraction in the vehicle tracking processes. In this paper, a broad discussion is introduced on algorithms for active safety functions, whilst a new dynamic algorithm is proposed. This approach handles all objects' states as dynamic stochastic variables and based on a Kalman approach calculates in real time all trajectories respectively. Thus, a reconstruction of the traffic scene can be achieved in order to assess a level of threat for all moving and stationary obstacles in the longitudinal area of the subject vehicle. This approach is adopted in the European co-funded project "EUCLIDE", which develops a vision enhancement and collision warning system merging the functionality of an infrared camera and mmw radar sensor. Results are presented using simulated and real data sets from dedicated sessions.
Does improving joint attention in low‐quality child‐care enhance language development?

This study examined effects of professional development for child‐care staff on language acquisition of children ages 14–36 months. Child‐care staff from 44 child‐care centres agreed to participate in the study. Child‐care staff from one‐half of the child‐care centres were randomly assigned to a one‐time, four‐hour workshop followed by three classroom visits over the subsequent three months. This treatment was designed to increase frequency and quality of joint attention episodes between the child‐care staff and the toddlers. Child‐care staff from the remaining 22 centres were assigned to a wait‐list control group. Toddlers (N = 121) in both the groups (n treatment = 64; n control = 57) were assessed with a measure of language acquisition after six months. While there were no significant differences on total language acquisition between groups, treatment group toddlers whose child‐care providers engaged in more frequent and longer bouts of joint attention acquired more language. The results of this study support that when child‐care staff engage in longer and higher quality bouts of joint attention with toddlers they can affect language acquisition.