Miracle-dz/UniFAR-FTUs huggingface dataset:
Is Dutch native English? Linguistic analysis by 2‐month‐olds

A variant of the non-nutritive habituation/dishabituation sucking method was used to test 2-month-old English infants’ perception of languages. This method tests for the spontaneous interest of the baby to a change in the stimulus. English and Japanese were clearly discriminated. The difference between French and Japanese was equally clearly not of interest to babies using this procedure, the babies behaving as though both languages were classified simply as ‘foreign’. In order to further specify babies’ representation of native and foreign language, we used Dutch, which shares a number of suprasegmental features with English. The results from our last 2 experiments indicate that a portion of our 6–12 week-old babies consider Dutch as native, suggesting that we tapped in a transition period where the babies are still refining the suprasegmental specification of their native language.
Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.

Previous in vivo turnover studies suggested that retarded clearance of low density lipoproteins (LDL) from the plasma of some hypercholesterolemic patients is due to LDL with defective receptor binding. The present study examined this postulate directly by receptor binding experiments. The LDL from a hypercholesterolemic patient (G.R.) displayed a reduced ability to bind to the LDL receptors on normal human fibroblasts. The G.R. LDL possessed 32% of normal receptor binding activity (approximately equal to 9.3 micrograms of G.R. LDL per ml were required to displace 50% of 125I-labeled normal LDL, vs. approximately equal to 3.0 micrograms of normal LDL per ml). Likewise, the G.R. LDL were much less effective than normal LDL in competing with 125I-labeled normal LDL for cellular uptake and degradation and in stimulating intracellular cholesteryl ester synthesis. The defect in LDL binding appears to be due to a genetic abnormality of apolipoprotein B-100: two brothers of the proband possess LDL defective in receptor binding, whereas a third brother and the proband's son have normally binding LDL. Further, the defect in receptor binding does not appear to be associated with an abnormal lipid composition or structure of the LDL: the chemical and physical properties of the particles were normal, and partial delipidation of the LDL did not alter receptor binding activity. Normal and abnormal LDL subpopulations were partially separated from plasma of two subjects by density-gradient ultracentrifugation, a finding consistent with the presence of a normal and a mutant allele. The affected family members appear to be heterozygous for this disorder, which has been designated familial defective apolipoprotein B-100. These studies indicate that the defective receptor binding results in inefficient clearance of LDL and the hypercholesterolemia observed in these patients.
Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

SUMMARY Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymphoproliferation and lymphomagenesis. In this review, we describe the biology of EBV and the host immune response. We review the diagnosis of EBV infection and discuss the characteristics and pathogenesis of infectious mononucleosis. These topics are approached in the context of developing therapeutic and preventative strategies.
Maximal accumulative respiration strain for the assessment of hepatic fibrosis

Early detection and grading of liver fibrosis are important for the treatment of chronic hepatitis. As the gold standard for the assessment of hepatic fibrosis, liver biopsy is invasive, and may cause hemorrhage and infection. Therefore, it is very important to develop noninvasive clinical methods for fibrosis assessment. In this paper, B-mode videos of the liver during peaceful respiration were acquired from two groups of people (8 healthy volunteers and 7 patients with biopsy-proven grade 4 fibrosis). All the videos were captured from the sagittal plane under the ensisternum where the hepatic tissue motion was almost in the imaging plane. After selecting a region of interest (ROI) in the hepatic tissue, the average strain of the hepatic tissue in the ROI was calculated from each adjacent frames. After that the accumulative strain during the whole respiration cycle was computed. Then the maximal accumulative respiration strain (MARS) during the respiration cycle was obtained. Significant difference between the MARS of these two groups was found. The mean MARS of the healthy group and fibrosis group were 29.45 and 15.19, respectively. The results indicated that the MARS was correlated to the hepatic fibrosis, and might be a potential parameter for hepatic fibrosis assessment.
Footedness across the Age Span among Brazilian Right- and Left-Handers

Previous cross-sectional surveys have reported a decreasing prevalence of left-footedness with increasing age. Bell and Gabbard attributed this pattern to a developmental process wherein the right hemisphere ages earlier than the left, leading to a decline in left-footedness among older individuals. A major flaw in this hypothesis is that age-related data were derived exclusively from right-handed samples. To test the generality of the hypothesis we obtained foot preferences from 1462 right and 172 left-handed Brazilians ranging from 10 to 94 years of age. In only one of the three analyses did dextrals show the predicted age-related decline. Together with accelerating trends towards left-footedness among older males and nonlinear trends among left-handers as a group, these results do not sustain the basic assumptions implicit in the right hemisphere aging hypothesis.
The Impact of a Strong Bank-Firm Relationship on the Borrowing Firm

Commercial banks acquire inside information about the firms they lend to. We study the impact of this informationally privileged position on the borrowing firm using a broad panel of U.S. firms over the 1993--2004 period. We measure the strength of the bank-firm relationship by bank-firm proximity, size of the loan, and the lender's insider potential. We show that a stronger relationship, by inducing better monitoring, improves the borrower's corporate governance. Simultaneously, it makes the bank a potentially more informed agent in the equity market. This information asymmetry increases adverse selection for the other market participants and lowers the firm's stock liquidity. This trade-off between improved corporate governance and greater information asymmetry affects the firm's value. Our results have normative implications for the role of banks in the development of financial markets. The Author 2009. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org. , Oxford University Press.
Disrupted ERK Signaling during Cortical Development Leads to Abnormal Progenitor Proliferation, Neuronal and Network Excitability and Behavior, Modeling Human Neuro-Cardio-Facial-Cutaneous and Related Syndromes

Genetic disorders arising from copy number variations in the ERK (extracellular signal-regulated kinase) MAP (mitogen-activated protein) kinases or mutations in their upstream regulators that result in neuro-cardio-facial-cutaneous syndromes are associated with developmental abnormalities, cognitive deficits, and autism. We developed murine models of these disorders by deleting the ERKs at the beginning of neurogenesis and report disrupted cortical progenitor generation and proliferation, which leads to altered cytoarchitecture of the postnatal brain in a gene-dose-dependent manner. We show that these changes are due to ERK-dependent dysregulation of cyclin D1 and p27Kip1, resulting in cell cycle elongation, favoring neurogenic over self-renewing divisions. The precocious neurogenesis causes premature progenitor pool depletion, altering the number and distribution of pyramidal neurons. Importantly, loss of ERK2 alters the intrinsic excitability of cortical neurons and contributes to perturbations in global network activity. These changes are associated with elevated anxiety and impaired working and hippocampal-dependent memory in these mice. This study provides a novel mechanistic insight into the basis of cortical malformation which may provide a potential link to cognitive deficits in individuals with altered ERK activity.
Elemental composition of marine Prochlorococcus and Synechococcus: Implications for the ecological stoichiometry of the sea

The elemental composition of marine cyanobacteria is an important determinant of the ecological stoichiometry in low‐latitude marine biomes. We analyzed the cellular carbon (C), nitrogen (N), and phosphorus (P) contents of Prochlorococcus (MED4) and Synechococcus (WH8103 and WH8012) under nutrient‐replete and P‐starved conditions. Under nutrient‐replete conditions, C, N, and P quotas (femtogram cell21) of the three strains were 46 ± 4, 9.4 ± 0.9, and 1.0 ± 0.2 for MED4; 92 ± 13, 20 6 3, and 1.8 ± 0.1 for WH8012; and 213 ± 7, 50 ± 2, 3.3 ± 0.5 for WH8103. In P‐limited cultures, they were 61 ± 2, 9.6 ± 0.1, and 0.3 ± 0.1 for MED4; 132 ± 6, 21 ± 2, and 0.5 ± 0.2 for WH8012; and 244 ± 21, 40 ± 4, and 0.8 ± 0.01 for WH8103. P limitation had no effect on the N cell quota of MED4 and WH8012 but reduced the N content of WH8103. The cellular C quota was consistently higher in P‐limited than in nutrient‐replete cultures. All three strains had higher C: P and N: P ratios than the Redfield ratio under both nutrient‐replete and P‐limited conditions. The C:N molar ratios ranged 5–5.7 in replete cultures and 7.1–7.5 in P‐limited cultures; C: P ranged 121–165 in the replete cultures and 464–779 under P limitation; N: P ranged 21–33 in the replete cultures and 59–109 under P limitation. Our results suggest that Prochlorococcus and Synechococcus may have relatively low P requirements in the field, and thus the particulate organic matter they produce would differ from the Redfield ratio (106C : 16N : 1P) often assumed for the production of new particulate organic matter in the sea.
Glucagon Receptor Knockout Mice Display Increased Insulin Sensitivity and Impaired β-Cell Function

In previous studies, glucagon receptor knockout mice (Gcgr−/−) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GLP)-1. However, the role of glucagon receptor signaling for the regulation of islet function and insulin sensitivity is unknown. We therefore explored β-cell function and insulin sensitivity in Gcgr−/− and wild-type mice. The steady-state glucose infusion rate during hyperinsulinemic-euglycemic clamp was elevated in Gcgr−/− mice, indicating enhanced insulin sensitivity. Furthermore, the acute insulin response (AIR) to intravenous glucose was higher in Gcgr−/− mice. The augmented AIR to glucose was blunted by the GLP-1 receptor antagonist, exendin-3. In contrast, AIR to intravenous administration of other secretagogues was either not affected (carbachol) or significantly reduced (arginine, cholecystokinin octapeptide) in Gcgr−/− mice. In islets isolated from Gcgr−/− mice, the insulin responses to glucose and several insulin secretagogues were all significantly blunted compared with wild-type mice. Furthermore, glucose oxidation was reduced in islets from Gcgr−/− mice. In conclusion, the present study shows that glucagon signaling is required for normal β-cell function and that insulin action is improved when disrupting the signal. In vivo, augmented GLP-1 levels compensate for the impaired β-cell function in Gcgr−/− mice.
Vasodilator response to systemic but not to local hyperinsulinemia in the human forearm.

Insulin-mediated vasodilation has been proposed as an important determinant of whole-body insulin-stimulated glucose disposal. However, it is not clear whether the vasodilator effect of insulin results from a direct action of the hormone or whether alternative mechanisms are involved. To better characterize the mechanism of insulin-mediated vasorelaxation, we compared forearm blood flow (FBF) responses to local (intra-arterial) and systemic (intravenous, euglycemic clamp) hyperinsulinemia in 10 healthy lean subjects using venous occlusion plethysmography. In addition, we assessed the effect of nitric oxide (NO) synthase inhibition by NG-monomethyl-L-arginine (L-NMMA) on the vasodilator and metabolic responses to hyperinsulinemia. Similar forearm concentrations of insulin were achieved during local and systemic infusion (231+/-39 versus 265+/-22 microU/mL; P=0.54). Of note, FBF did not change significantly in response to local hyperinsulinemia (from 2.6+/-0.3 to 2.4+/-0.3 mL . min-1 . dL-1; P=0.50). In contrast, systemic hyperinsulinemia caused a 52% increase in FBF (from 2.5+/-0.2 to 3. 8+/-0.5 mL . min-1 . dL-1; P<0.004), which was reversed by L-NMMA (FBF decreased from 3.8+/-0.5 to 2.3+/-0.2 mL . min-1 . dL-1; P=0. 004). We conclude that systemic, but not local, hyperinsulinemia induces vasodilation in the forearm. Our findings suggest that insulin-mediated vasodilation is not due solely to a direct stimulatory effect of insulin but involves additional mechanisms activated only during systemic hyperinsulinemia.
The Role of Sustainability Orientation and Sustainable Environmental Performance in Improving Sustainable Economic Performance of the Batik Industry

The batik industry is starting to develop rapidly, and its contribution is improving the Indonesian economy. On the other hand, the batik industry produces waste that pollutes the environment. Batik SMEs do not realize the importance of sustainability orientation, and that some consumers prefer environmentally friendly batik products. The purpose of this study was to examine the relationship between sustainability orientation and sustainable economic performance, both directly and through sustainable environmental performance. The study was conducted in Surabaya, as well as the Regencies of Tuban, Lamongan, Sidoarjo, and Jombang. With the purposive sampling technique, 32 Batik SMEs were selected with 89 respondents. SEM-PLS was the method of data analysis used in this investigation. According to data analysis findings, sustainable economic performance benefits from sustainable environmental performance. Sustainable environmental performance is positively impacted by sustainability orientation. Sustainable economic performance is not directly impacted by sustainability orientation. Sustainability orientation indirectly influences sustainability economic performance through sustainable environmental performance. Increasing sustainability orientation can increase sustainable environmental and economic performance for realising the green batik industry. Keywords: sustainable development, sustainability orientation, sustainable economic performance, green batik industry
Growth vs. Level Effect of Population Change on Economic Development: An Inspection into Human-Capital-Related Mechanisms

This paper studies the different mechanisms and the dynamics through which demography is channeled to the economy. We analyze the role of demographic changes in the economic development process by studying the transitional and the long-run impact of both the rate of population growth and the initial population size on the levels of per capita human capital and income. We do that in an enlarged Lucas–Uzawa model with intergenerational altruism. In contrast to the existing theoretical literature, the long-run level effects of demographic changes, i.e. their impact on the levels of the variables along the balanced growth path, are deeply characterized in addition to the more standard long-run growth effects. We prove that the level effect of the population rate of growth is non-negative (positive in the empirically most relevant case) for the average level of human capital, but a priori ambiguous for the level of per capita income due to the interaction of three transmission mechanisms of demographic shocks, a standard one (dilution) and two non-standard (altruism and human capital accumulation). Overall, the sign of the level effects of population growth depends on preference and technology parameters, but numerically we show that the joint negative effect of dilution and altruism is always stronger than the induced positive human capital effect. The growth effect of population growth depends basically on the attitude to intergenerational altruism and intertemporal substitution. Moreover, we also prove that the long-run level effects of population size on per capita human capital and income may be negative, nil, or positive, depending on the relationship between preferences and technology, while its growth effect is zero. Finally, we show that the model is able to replicate complicated time relationships between economic and demographic changes. In particular, it entails a negative effect of population growth on per capita income, which dominates in the initial periods, and a positive effect which restores a positive correlation between population growth and economic performance in the long term.
Alouatta Trichromatic Color Vision: Cone Spectra and Physiological Responses Studied with Microspectrophotometry and Single Unit Retinal Electrophysiology

The howler monkeys (Alouatta sp.) are the only New World primates to exhibit routine trichromacy. Both males and females have three cone photopigments. However, in contrast to Old World monkeys, Alouatta has a locus control region upstream of each opsin gene on the X-chromosome and this might influence the retinal organization underlying its color vision. Post-mortem microspectrophotometry (MSP) was performed on the retinae of two male Alouatta to obtain rod and cone spectral sensitivities. The MSP data were consistent with only a single opsin being expressed in each cone and electrophysiological data were consistent with this primate expressing full trichromacy. To study the physiological organization of the retina underlying Alouatta trichromacy, we recorded from retinal ganglion cells of the same animals used for MSP measurements with a variety of achromatic and chromatic stimulus protocols. We found MC cells and PC cells in the Alouatta retina with similar properties to those previously found in the retina of other trichromatic primates. MC cells showed strong phasic responses to luminance changes and little response to chromatic pulses. PC cells showed strong tonic response to chromatic changes and small tonic response to luminance changes. Responses to other stimulus protocols (flicker photometry; changing the relative phase of red and green modulated lights; temporal modulation transfer functions) were also similar to those recorded in other trichromatic primates. MC cells also showed a pronounced frequency double response to chromatic modulation, and with luminance modulation response saturation accompanied by a phase advance between 10–20 Hz, characteristic of a contrast gain mechanism. This indicates a very similar retinal organization to Old-World monkeys. Cone-specific opsin expression in the presence of a locus control region for each opsin may call into question the hypothesis that this region exclusively controls opsin expression.
Nutrition-related claims on children's cereals: what do they mean to parents and do they influence willingness to buy?

Abstract Objective To examine parents’ beliefs about the meaning of common front-of-package nutrition-related claims on children's cereals and determine whether the claims would make them more willing to buy the cereals. Design Parents viewed images of box fronts for children's cereals of below-average nutritional quality, as assessed by a validated nutrient profiling model. These boxes featured various nutrition-related claims including ‘supports your child's immunity’, ‘whole grain’, ‘fibre’, ‘calcium and vitamin D’ and ‘organic’. Participants were provided possible meanings for these claims and asked to select any that applied with the option to write in additional meanings. They also indicated how the claim would affect their willingness to buy the product. Setting Online survey. Subjects Parents with children between the ages of 2 and 11 years (n 306) recruited through an online panel. Results The majority of parents misinterpreted the meaning of claims commonly used on children's cereals. They inferred that cereals with claims were more nutritious overall and might provide specific health-related benefits for their children; and these beliefs predicted greater willingness to buy the cereals. Conclusions These findings indicate that common front-of-package nutrition-related claims are potentially misleading, especially when placed on products with high levels of nutrients to limit (e.g. sugar, sodium) and low levels of other nutrients to encourage (e.g. fibre, protein). Additional regulation is needed to protect consumers in the USA.
Towards low-dimensional hole systems in Be-doped GaAs nanowires

GaAs was central to the development of quantum devices but is rarely used for nanowire-based quantum devices with InAs, InSb and SiGe instead taking the leading role. p-type GaAs nanowires offer a path to studying strongly confined 0D and 1D hole systems with strong spin–orbit effects, motivating our development of nanowire transistors featuring Be-doped p-type GaAs nanowires, AuBe alloy contacts and patterned local gate electrodes towards making nanowire-based quantum hole devices. We report on nanowire transistors with traditional substrate back-gates and EBL-defined metal/oxide top-gates produced using GaAs nanowires with three different Be-doping densities and various AuBe contact processing recipes. We show that contact annealing only brings small improvements for the moderately doped devices under conditions of lower anneal temperature and short anneal time. We only obtain good transistor performance for moderate doping, with conduction freezing out at low temperature for lowly doped nanowires and inability to reach a clear off-state under gating for the highly doped nanowires. Our best devices give on-state conductivity 95 nS, off-state conductivity 2 pS, on-off ratio ∼ 10 4 , and sub-threshold slope 50 mV/dec at T = 4 K. Lastly, we made a device featuring a moderately doped nanowire with annealed contacts and multiple top-gates. Top-gate sweeps show a plateau in the sub-threshold region that is reproducible in separate cool-downs and indicative of possible conductance quantisation highlighting the potential for future quantum device studies in this material system.
Minimum-phase impulse response channels

We give a sufficient condition that insures that the impulse response of a channel is of minimum phase. The condition is that the energy of the first path be larger than the power spectral density of all subsequent paths. Establishing a lower bound to the first path energy, this condition is more likely to be met if transmitter and receiver are in line-of-sight. Our results show that the Hilbert transform may give unreliable results, if used to extract the channel phase response from frequency-resolved amplitude measurements when the first path is strongly attenuated.
DEFENSE OF OVIPOSITION SITES BY FEMALE ORIENTAL FRUIT FLIES ( DIPTERA : TEPHRITIDAE )

T OWNES , H. 1969. The genera of Ichneumonidae, part 1. Memoirs of the American Entomological Institute 11: 1-300. V ERHOEFF , C. 1891. Biologische Aphorismen über einige Hymenopteren, Dipteren und Coleopteren. Verh. naturh. Ver. Reinl. 48: 1-80. W AHL , D. B. 1986. Larval structures of oxytorines and their significance for the higher classification of some Ichneumonidae (Hymenoptera). Syst. Entomol. 117-127. W OLF , H. 1953. Beiträge zur Hymenopterenfauna des oberen Lahn-Dill-Sieg-Gebites.