Miracle-dz/UniFAR-FTUs huggingface dataset:
March's Gendered Madness: An Analysis of Print Media Representations of a Female Division I NCAA Women's Basketball Coach - Pat Summitt

This study explores the extent to which national newspaper coverage of a successful female coach reflects the broader gender ideology of society. This study looks specifically at the New York Times, The Washington Post and USA Today’s coverage of six Women’s Division I national basketball tournaments in which Pat Summitt coached the University of Tennessee in the championship game. The years included for analysis are 1996, 1997, 1998, 2000, 2003 and 2004. This rhetorical analysis examines this print coverage of Summitt to determine if, consistent with previous research on media coverage of the female athlete, Summitt’s traditional gender role is privileged over her coaching role. The results suggest that Summitt is characterized in ways that marginalize and trivialize her coaching accomplishments. The findings also suggest that even as women succeed in the male-dominated world of sport, societal pressures require that they be presented as properly gendered heterosexual females. INDEX WORDS: Pat Summitt, Female athletes, Gender stereotypes, Female coaches, Women’s basketball, College basketball, Media coverage, Lesbians and sport, Title IX MARCH’S GENDERED MADNESS: AN ANALYSIS OF PRINT MEDIA REPRESENTATIONS OF A FEMALE DIVISION I NCAA WOMEN’S BASKETBALL COACH— PAT SUMMITT
Influence of Aerobic Training and Combinations of Interventions on Cognition and Neuroplasticity after Stroke

Stroke often aggravated age-related cognitive impairments that strongly affect several aspects of quality of life. However, few studies are, to date, focused on rehabilitation strategies that could improve cognition. Among possible interventions, aerobic training is well known to enhance cardiovascular and motor functions but may also induce beneficial effects on cognitive functions. To assess the effectiveness of aerobic training on cognition, it seems necessary to know whether training promotes the neuroplasticity in brain areas involved in cognitive functions. In the present review, we first explore in both human and animal how aerobic training could improve cognition after stroke by highlighting the neuroplasticity mechanisms. Then, we address the potential effect of combinations between aerobic training with other interventions, including resistance exercises and pharmacological treatments. In addition, we postulate that classic recommendations for aerobic training need to be reconsidered to target both cognition and motor recovery because the current guidelines are only focused on cardiovascular and motor recovery. Finally, methodological limitations of training programs and cognitive function assessment are also developed in this review to clarify their effectiveness in stroke patients.
BCR‐ABL influences the antileukaemic efficacy of alkylphosphocholines

We have compared the antileukaemic efficacy of a series of new i.v. injectable alkylphosphocholines (APC) with their clinically used congeners miltefosine and perifosine. The test system consisted of four leukaemic cell lines carrying the bcr‐abl rearrangement (K‐562, LAMA‐84, CML‐T1 and BV‐173) and two other leukaemic cell lines (HL‐60 and SKW‐3) without this genetic alteration. The prototype of i.v. injectable APC, erucylphosphocholine, was more active against BCR‐ABL‐positive cell lines than the two reference APC. It induced programmed cell death in HL‐60 and SKW‐3 cells after exposure for 24 h, and in bcr‐abl expressing cells after a prolonged incubation period (48 h). LAMA‐84 cells responded to i.v. injectable APC with increased conversion to an adherent, fibroblast‐like phenotype. Experiments with a cell‐free system showed that the target structures of APC are localized within the cytoplasmic compartment. Blockade of ceramide synthase by fumonisin B1 was insufficient to prevent oligonucleosomal DNA fragmentation. Using RT‐PCR we confirmed that K‐562 and LAMA‐84 cells carry the b3a2 fusion type, and CML‐T1 and BV‐173 the b2a2 variant. BV‐173 cells had the lowest level of bcr‐abl mRNA which correlated with their increased sensitivity. Transfection of K‐562 cells with antisense oligonucleotides directed against bcr‐abl caused a specific suppression of K‐562 clonogenicity. Our data indicated that i.v. injectable alkylphosphocholines are potent inducers of apoptosis and display increased antileukaemic efficacy against BCR‐ABL‐positive blasts as compared with miltefosine and perifosine. The expression of BCR‐ABL cannot prevent apoptosis but delays erucylphosphocholine‐induced programmed cell death. Transfection with bcr‐abl directed antisense oligonucleotides reduces the clonogenicity of K‐562 cells.
Electrostatic trapping of metastable NH molecules

We report on the Stark deceleration and electrostatic trapping of $^{14}\text{N}\text{H}$ $(a^{1}\ensuremath{\Delta})$ radicals. In the trap, the molecules are excited on the spin-forbidden $A^{3}\ensuremath{\Pi}\ensuremath{\leftarrow}a^{1}\ensuremath{\Delta}$ transition and detected via their subsequent fluorescence to the $X{^{3}\ensuremath{\Sigma}}^{\ensuremath{-}}$ ground state. The $1∕e$ trapping time is $1.4\ifmmode\pm\else\textpm\fi{}0.1\text{ }\text{s}$, from which a lower limit of 2.7 s for the radiative lifetime of the $a^{1}\ensuremath{\Delta}$, $v=0$, $J=2$ state is deduced. The spectral profile of the molecules in the trapping field is measured to probe their spatial distribution. Electrostatic trapping of metastable NH followed by optical pumping of the trapped molecules to the electronic ground state is an important step toward accumulation of these radicals in a magnetic trap.
NVP-BEZ235 as a New Therapeutic Option for Sarcomas

Purpose: To evaluate the in vitro and in vivo effects of NVP-BEZ235, a dual pan-phosphoinositide 3-kinase–mammalian target of rapamycin inhibitor in the three most common musculoskeletal tumors (osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma). Experimental Design: Antiproliferative activity as well as the effects on migration and metastasis were evaluated in a panel of osteosarcoma, Ewing's sarcoma, as well as rhabdomyosarcoma cell lines. Moreover, simultaneous and sequential treatments were done in association with two of the most important conventional drugs in the treatment of sarcoma, doxorubicin and vincristine. Results: NVPBEZ235 effectively blocked the pathway in in vitro and in vivo settings. Under the experimental conditions tested, the compound induced disease stasis, by arresting cells in G1 phase of cell cycle, without remarkable effects on apoptosis. As a consequence, to obtain the maximum exploitation of its therapeutic potential, NVP-BEZ235 has been evaluated in combination with conventional cytotoxic agents, thus showing promising efficacy with either doxorubicin and vincristine. Inhibition of the phosphoinositide 3-kinase/mammalian target of rapamycin pathway increased activation of extracellular signal-regulated kinase 1/2, likely due to the presence of autocrine circuits shifting growth factor signaling toward the mitogen-activated protein kinase pathway. This supports the combined use of NVP-BEZ235 with other small signaling inhibitors. Here, we showed synergistic effects when the compound was associated with a anti–insulin-like growth factor-I receptor tyrosine kinase inhibitor. NVP-BEZ235 also inhibited cell migration and metastasis. Combination with vincristine further potentiated the antimetastatic effects. Conclusions: NVP-BEZ235 displays the features to be considered for sarcoma therapy to potentiate the activity of other anticancer agents. The drug is currently undergoing phase I/II clinical trials in advanced cancer patients. Clin Cancer Res; 16(2); 530–40
Real-Time Implementation of a General Model for Spatial Processing of Sounds

We perceive sounds in a spatial context. Without visual cues, we can often tell the direction or distance from which a sound comes. We also perceive things about the apparent acoustic environment of sounds, such as whether they seem to come from a reverberant cave or a padded cell. Multichannel recordings can portray the spatial characteristics of recorded sounds independent of listening conditions. In ways analogous to looking through windows, we can discern things about one acoustic environment through headphones or loudspeakers while we move about in another. Ideally, spatial processing of sounds would allow us to have complete control over the acoustic environment heard through the loudspeakers. Each sound located within this heard environment could have a specified "size," direction, distance, and apparent motion. We can use computers to gain such control over the spatial characteristics of sounds, but for musical applications we must always specify the acoustic processing we believe will produce the intended psychological effect. Spatial processing therefore involves the simultaneous consideration of two sets of problems: the physical characteristics of a space to be simulated and the psychological characteristics of sounds presented to listeners over loudspeakers. The work described in this article consists of (1) a conceptual model for representing the problem of spatial processing and (2) a description of an implementation of this model in the context of the Cmusic sound synthesis program (Moore 1982). Localization
Radiographic study of the root canal system of mandibular incisors in Palestinian population

Aim: The aim of this study was to survey the root canal morphology of mandibular incisor teeth in a Palestinian population using radiographic approach. Materials and Methods: Five hundred and twenty two extracted mandibular incisor teeth were randomly collected from Palestinian population. The teeth were radiographed from a mesiodistal direction and examined for the presence of a second canal and for the type of canal configuration. Results: All teeth had single root. Three hundred and sixty nine teeth (70.7%) had one canal (type I Vertucci classification). The rest (29.3%) had a second canal (type II and III). Conclusion: Mandibular central and lateral teeth were mostly found to have one root and Type I canal system.
"White coat hypertension" in adolescents: increased values of urinary cortisol and endothelin.

OBJECTIVE To investigate whether "white coat hypertension" (WCH) in adolescents is an innocent phenomenon or is associated with early changes of the vascular system and/or increased stress response, reflected in the urinary endothelin and cortisol values, respectively. STUDY DESIGN The study group included 36 subjects, 14 with WCH (8 males and 6 females) aged 12.9 +/- 3 years and 22 normotensive control subjects (12 males and 10 females) aged 13 +/- 3.5 years. WCH was defined as systolic and/or diastolic blood pressure (BP) > or =95th percentile for age, sex, and height and with reported normal BP measurements at home. Urinary endothelin (UET1), urinary free cortisol (UFC), and plasma renin levels were determined by radioimmunoassay; and urinary albumin levels were determined by nephelometry. For statistical analysis, the Mann Whitney U test, Spearman correlation coefficient, and multivariate analysis of variance/multivariate analysis of covariance were used, as applicable. RESULTS The 24-hour values of UET1 and UFC were greater in male subjects with WCH than in male control subjects (P =.02), whereas no such difference was found in female subjects. The difference in UFC values in male subjects was accounted for by the day values. In subjects with WCH, and not in control subjects, a positive correlation of UET1 to UFC (r = 0.59, P =.027), diastolic BP (r = 0.55, P =.04), and mean BP (r = 0.65, P =.012) was detected. CONCLUSIONS Our data indicate that WCH in adolescence may not be an innocent phenomenon and may represent a prelude to permanent idiopathic hypertension of adulthood.
Gallbladder Hypoplasia, a Congenital Abnormality of the Gallbladder: A Case Report

Patient: Male, 62 Final Diagnosis: Gallbladder hypoplasia Symptoms: Abdominal pain Medication: — Clinical Procedure: — Specialty: Surgery Objective: Congenital defects/diseases Background: There are different variations in the anatomy of the gallbladder. Congenital abnormalities of the gallbladder such as agenesis and hypoplasia are rare conditions and difficult to diagnose with imaging studies. Patients are usually asymptomatic or have symptoms that mimic gallstone disease. The diagnosis is often made intraoperatively and is established by histopathological examination. Case Report: We report a case of a 62-year-old male who had cholelithiasis symptoms and was falsely diagnosed with gallstone disease by abdominal ultrasound scan. The patient underwent an operation which revealed a rudimentary gallbladder. The histology result showed hypoplastic gallbladder tissue. Conclusions: This case suggests that surgeons need to take into consideration congenital anomalies of the gallbladder intraoperatively in order to avoid any iatrogenic injury to biliary tract during a routine laparoscopic cholecystectomy. Intraoperative cholangiography can be a useful tool to avoid unnecessary surgical risky interventions.
Endometrial stromal sarcoma in combination with mixed type endometrial carcinomas

Rationale: Endometrial stromal sarcoma (ESS) is rare, representing only approximately 0.2% of all uterine malignancies. Mixed type endometrial carcinomas (MT-ECs) are rare tumors with both type I and II features, and are difficult to diagnose. Cases of ESS and MT-ECs coexisting in the same patient are extremely rare. This study aimed to describe a case of ESS in combination with MT-ECs in a 47-year-old premenopausal woman. Patient concerns: A woman presented to the hospital complaining of occasional abdominal pain and had high tumor markers: cancer antigen (CA) 19–9 (263.6 U/mL) and CA 125 (428.0 U/mL). Transvaginal ultrasound examination revealed a complex mass (12.3 × 9.1 × 6.3 cm) with solid and cystic components on the right rear wall of the uterus. Abdominopelvic computed tomography images showed a pelvic cystic-solid mixed mass. The patient underwent an exploratory midline laparotomy. The mass was hypothesized to be malignant on the uterine posterior wall. Tumor deposits were found on bilateral parametrium. On peritoneal implantation, multiple metastases were seen on the serosal surface of the bowel and greater omentum. A frozen section revealed a spindle cell sarcoma. Diagnoses: Pathological reports following surgery revealed concurrent ESS and MT-ECs. Interventions: The patient underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, total omentectomy, and macroscopic clearance of the tumor. Adjuvant chemotherapy was given. Outcomes: The patient was still alive when this report was written. Lessons: Considering the rarity of ESS in combination with MT-ECs, this study presented an overview of the literature and discussed a number of histological and clinical issues. Nevertheless, etiology and pathogenesis of these tumors need further investigation.
Internet Recruitment of Asian American Breast Cancer Survivors

The purpose of this article is to identify practical issues in Internet recruitment of racial/ethnic minorities by analyzing an Internet intervention study conducted with Asian American breast cancer survivors, and to propose directions for recruitment of racial/ethnic minorities for future Internet research. Six practical issues were identified: (a) a relatively fewer number of Internet communities/groups; (b) hindrances in establishing authenticity; (c) difficulties in gaining entrée from the webmasters or Web site owners of Internet communities/groups; (d) the necessity of racially/ethnically matched research team members; (e) flexibility required in recruitment strategies; and (f) strategies to overcome the low response rate.
Sentence processing strategies in adult bilinguals

Bates and MacWhinney and their colleagues (1981, 1982, 1984) have shown that native speakers depend on a particular set of probabilistic cues to assign formal surface devices in their language to a specified set of underlying functions. The research program encompassed by their approach to language processing has extended from describing crosslinguistic processing differences in even typologically similar languages (e.g., English and Italian, both SVO languages), to charting the pattern of acquisition of grammatical ''rules" in the first language, and more recently to crosslanguage investigations of "characteristic" neurological-based language deficits. A natural extension of this broad experimental effort is in a field that involves issues of both language learning and sentence processing in adults: late second language acquisition. Given the large volume of rlata already collected from monolingual speakers, we are now in a position to begin exploration into bilingual sentence processing strategies. In this chapter we report on sentence processing experiments carried out with adults who speak two or more languages. The notion that cues vary in strength has proven valuable in describing the psychologically relevant features of different kinds of languages; it may also provide a window into the psycholinguistic properties of second language acquisition. Students of language study come from many schools; not all share our assumptions or biases regarding the kinds of questions that are germane to second language acquisition, nor what constitutes an answer to those questions. For this reason, we will briefly review a small part of the history of second language acquisition research that lies behind the work presented here. We will focus on two issues: the influence of first language acquisition research on work in second language learning, and the role of rules in characterizing language acquisition of either kind.
Effects of 8-Wk α-Glucosidase Inhibition on Metabolic Control, C-Peptide Secretion, Hepatic Glucose Output, and Peripheral Insulin Sensitivity in Poorly Controlled Type II Diabetic Patients

Miglitol (BAYm 1099), an α-glucosidase inhibitor, reduces the postprandial increase of blood glucose and serum insulin levels in type II (non-insulin-dependent) diabetes mellitus, as shown in short-term studies. In this study, the effects of long-term miglitol treatment on metabolic control, C-peptide secretion, hepatic glucose output, and peripheral insulin sensitivity (euglycemic clamp) were tested in 15 type II diabetic patients (8 receiving insulin, 7 receiving oral hypoglycemic agents). For 8 wk they received either miglitol (300 mg/day) or placebo with a double-blind crossover design that had a 4-wk washout period between treatments. Miglitol therapy induced a reduction of postprandial blood glucose levels (miglitol compared with placebo; areas under the curve; P > .002), whereas fasting blood glucose levels were not influenced. Miglitol caused a slight reduction of glycosylated hemoglobin levels (mean ± SE miglitol and placebo 9.50 ± 0.3 and 10.0 ± 0.4%, respectively; P > .05), which was more pronounced in insulin-treated patients. Miglitol caused a reduction of postprandial C-peptide increase (P > .03). Hepatic glucose output (both in the basal state and during euglycemic clamp conditions) and peripheral insulin sensitivity were not influenced by miglitol therapy. Specific side effects were observed in 11 patients; in 6 patients only to a moderate degree. - Long-term miglitol treatment induces a persistent reduction of postprandial blood glucose increase. This effect is more pronounced in type II diabetic patients on insulin therapy, which can cause a moderate improvement of overall metabolic control.
Prosocial capabilities in Alzheimer's patients.

OBJECTIVES To examine the decision making of Alzheimer's patients in a simple, classic game focusing on their capabilities to implement social norms and common social preferences. METHODS Patients with Stage I (very mild and mild) Alzheimer's disease (AD) were asked to participate in a dictator game, a type of game in which a subject has to decide how to allocate a certain amount of money between himself and another person. RESULTS When we compared the results of treatments involving AD patients (at an early stage) with those of identical treatments involving patients with mild cognitive impairment or healthy elderly controls, with similar ages and social backgrounds, we did not find statistically significant differences. DISCUSSION This finding suggests that Stage I AD patients are as capable of making decisions involving basic social norms and preferences as other individuals of their age. Whatever brain structures are affected by the disease, they do not appear to influence, at this early stage, the neural basis for cooperation-enhancing social interactions.
Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells

Phagocytic processing of heat-killed Listeria monocytogenes by peritoneal macrophages resulted in degradation of these bacteria in phagolysosomal compartments and processing of bacterial antigens for presentation to T cells by class II MHC molecules. Within 20 min of uptake by macrophages, Listeria peptide antigens were expressed on surface class II MHC molecules, capable of stimulating Listeria- specific T cells. Within this period, degradation of labeled bacteria to acid-soluble low molecular weight catabolites also commenced. Immunoelectron microscopy was used to evaluate the compartments involved in this processing. Upon uptake of the bacteria, phagosomes containing Listeria fused rapidly with both lysosomes and endosomes. Class II MHC molecules were present in a tubulo-vesicular lysosome compartment, which appeared to fuse with phagosomes, as well as in the resulting phagolysosomes containing internalized Listeria; these compartments were all positive for Lamp 1 and cathepsin D and lacked 46- kD mannose-6-phosphate receptors. In addition, class II MHC and Lamp 1 were co-localized in vesicles of the trans Golgi reticulum, where they were segregated from 46-kD mannose-6-phosphate receptors. Vesicles containing both Listeria-derived components and class II MHC molecules were also observed; some of these may represent vesicles recycling from phagolysosomes, potentially bearing processed immunogenic peptides complexed with class II MHC. These results support a central role for lysosomes and phagolysosomes in the processing of bacterial antigens for presentation to T cells. Tubulo-vesicular lysosomes appear to represent an important convergence of endocytic, phagocytic and biosynthetic pathways, where antigens may be processed to allow binding to class II MHC molecules and recycling to the cell surface.
Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo

Human interferon-inducible protein 10 (IP-10), a member of the alpha chemokine family, inhibits bone marrow colony formation, has antitumor activity in vivo, is chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells. Here we report that IP-10 is a potent inhibitor of angiogenesis in vivo. IP-10 profoundly inhibited basic fibroblast growth factor-induced neovascularization of Matrigel (prepared by H. K. Kleinman) injected subcutaneously into athymic mice. In addition, IP-10, in a dose-dependent fashion, suppressed endothelial cell differentiation into tubular capillary structures in vitro. IP-10 had no effect on endothelial cell growth, attachment, and migration as assayed in vitro. These results document an important biological property of IP-10 and raise the possibility that IP-10 may participate in the regulation of angiogenesis during inflammation and tumorigenesis.