Miracle-dz/UniFAR-FTUs huggingface dataset:
Variability in State-Dependent Plasticity of Intrinsic Properties during Cell-Autonomous Self-Regulation of Calcium Homeostasis in Hippocampal Model Neurons1,2,3

Abstract How do neurons reconcile the maintenance of calcium homeostasis with perpetual switches in patterns of afferent activity? Here, we assessed state-dependent evolution of calcium homeostasis in a population of hippocampal pyramidal neuron models, through an adaptation of a recent study on stomatogastric ganglion neurons. Calcium homeostasis was set to emerge through cell-autonomous updates to 12 ionic conductances, responding to different types of synaptically driven afferent activity. We first assessed the impact of theta-frequency inputs on the evolution of ionic conductances toward maintenance of calcium homeostasis. Although calcium homeostasis emerged efficaciously across all models in the population, disparate changes in ionic conductances that mediated this emergence resulted in variable plasticity to several intrinsic properties, also manifesting as significant differences in firing responses across models. Assessing the sensitivity of this form of plasticity, we noted that intrinsic neuronal properties and the firing response were sensitive to the target calcium concentration and to the strength and frequency of afferent activity. Next, we studied the evolution of calcium homeostasis when afferent activity was switched, in different temporal sequences, between two behaviorally distinct types of activity: theta-frequency inputs and sharp-wave ripples riding on largely silent periods. We found that the conductance values, intrinsic properties, and firing response of neurons exhibited differential robustness to an intervening switch in the type of afferent activity. These results unveil critical dissociations between different forms of homeostasis, and call for a systematic evaluation of the impact of state-dependent switches in afferent activity on neuronal intrinsic properties during neural coding and homeostasis.
Memory access time as entropy source for RNG

Most modern cryptographic systems cannot function properly without a reliable random number generator [1-8]. There are many approaches to the construction of the RNGs, but they all have several disadvantages. This paper provides a new approach for constructing truly random number generator, based on non-stability of memory access time. The developers have tried to describe methodology for obtaining and filtering random values from Intel-based systems without additional hardware.
An Inflammatory Pseudotumor Arising from Pterygopalatine Fossa with Invasion to the Maxillary Sinus and Orbital Cavity

We report a patient who had an inflammatory pseudotumor (IPT) that invaded to the maxillary sinus and orbital cavity, with the left pterygopalatine fossa as the principal site; this is a very rare case. The patient was an 83-year-old woman who suddenly became aware of impairment in the eyesight and visual field of the left eye. CT images showed a neoplastic lesion that invaded to the maxillary sinus and orbital cavity, with the left pterygopalatine fossa as the principal site, and also showed contrast effects. To obtain a definitive diagnosis from histopathological analysis, the lesion was biopsied, and she was diagnosed as the inflammatory pseudotumor with the immunohistochemical study and multiplex polymerase chain reaction-based clonality assays. The patient had a lymphoid-predominant lesion that responded to radiotherapy but corticosteroids were not effective. It is important to scrutinize the pathology to avoid unnecessary and mutilating surgery.
Intuition in Judgment and Decision Making: Extensive Thinking Without Effort

We claim that intuition is capable of quickly processing multiple pieces of information without noticeable cognitive effort. We advocate a component view stating that intuitive processes in judgment and decision making are responsible for information integration and output formation (e.g., preference, choice), whereas analytic thinking mainly guides input formation such as search, generation, and change of information. We present empirical evidence corroborating this notion and show that integration of information and preference formation works without cognitive control and is unconstrained by the amount of encoded information and cognitive capacity. We discuss the implications of our findings for the bounded rationality perspective and the multiple strategy approach to judgment and decision making. Finally we outline a connectionist framework for integrating intuitive and analytic thought processes.
A Systematic Review of the Evidence Base for Schema Therapy

Schema Therapy is becoming an increasingly popular psychological model for working with individuals who have a variety of mental health and personality difficulties. The aim of this review is to look at the current evidence base for Schema Therapy and highlight directions for further research. A systematic search of the literature was conducted up until January 2011. All studies that had clinically tested the efficacy of Schema Therapy as described by Jeffrey Young (1994 and 2003) were considered. These studies underwent detailed quality assessments based on Scottish Intercollegiate Guidelines Network (SIGN-50) culminating in 12 studies being included in the review. The culminative message (both from the popularity of this model and the medium-to-large effect sizes) is of a theory that has already demonstrated clinically effective outcomes in a small number of studies and that would benefit from ongoing research and development with complex client groups. It is imperative that psychological practice be guided by high-quality research that demonstrates efficacious, evidence-based interventions. It is therefore recommended that researchers and clinicians working with Schema Therapy seek to build on these positive outcomes and further demonstrate the clinical effectiveness of this model through ongoing research.
Spectral and Topographic Microstructure of Brain Alpha Activity During Drowsiness at Sleep Onset and REM Sleep

Abstract High-resolution frequency methods were used to describe the spectral and topographic microstructure of human spontaneous alpha activity in the drowsiness (DR) period at sleep onset and during REM sleep. Electroencephalographic (EEG), electrooculographic (EOG), and electromyographic (EMG) measurements were obtained during sleep in 10 healthy volunteer subjects. Spectral microstructure of alpha activity during DR showed a significant maximum power with respect to REM-alpha bursts for the components in the 9.7-10.9 Hz range, whereas REM-alpha bursts reached their maximum statistical differentiation from the sleep onset alpha activity at the components between 7.8 and 8.6 Hz. Furthermore, the maximum energy over occipital regions appeared in a different spectral component in each brain activation state, namely, 10.1 Hz in drowsiness and 8.6 Hz in REM sleep. These results provide quantitative information for differentiating the drowsiness alpha activity and REM-alpha by studying their microstructural .
Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions.

BACKGROUND A relation between telomere attrition in early carcinogenesis and activation of DNA damage response (DDR) has been proposed. We explored telomere length and its link with DDR in colorectal multistep carcinogenesis. PATIENTS AND METHODS We studied normal mucosa, low-grade dysplasia (LGD) and high-grade dysplasia (HGD) and invasive carcinoma (IC) in matched human colon specimens by evaluating p-ataxia telangiectasia mutated (ATM), p-checkpoint kinase 2 (Chk2), c-H2AX, TRF1 and TRF2 expressions by immunohistochemistry. FISH was used to assess telomere length. RESULTS Telomeres shortened significantly from normal (N) to LGD and HGD (P < 0.0001; P = 0.012), then increased in length in IC (P = 0.006). TRF1 and TRF2 expressions were diminished from N to LGD and HGD (P = 0.004, P < 0.0001, ns) and were reexpressed at the invasive stage (P = 0.053 and P = 0.046). Phosphorylated ATM, Chk2 and H2AX appeared already in LGD (respectively, P = 0.001, P = 0.002 and P = 0.02). Their expression decreased from HGD to IC (respectively, P = 0.03, P = 0.02 and P = 0.37). These activating phosphorylations were inversely correlated with telomere length and TRF1/2 expression. CONCLUSION In a model of colon multistep carcinogenesis, our data indicate that telomeric length and protein expression levels are inversely correlated with the activation of the DDR pathway.
Shear-induced melting of two-dimensional solids.

We have carried out detailed nonequilibrium molecular-dynamics simulation studies of the shear-induced melting transition of a model two-dimensional solid. We find that the shear melting of the two-dimensional soft-disk solid at temperature [ital T]=1 and density [rho]=1.03 occurs in two stages: (1) a transition from elastic to plastic behavior takes place as soon as any finite shear rate is applied; (2) qualitative changes in structural and dynamic behavior occur near a shear rate of [gamma]=0.07. For [gamma][approx lt]0.07, the system possesses very long-range bond-orientational correlations, and the instantaneous static structure factor exhibits pronounced sixfold anisotropy, with a sixfold pattern that rotates uniformly with time in response to the applied shear. For [gamma][approx gt]0.07, the system behaves like an ordinary two-dimensional liquid under shear in that the ranges of translational and bond-orientational correlations are comparable and the instantaneous static structure factor does not exhibit persistent sixfold anisotropy. We discuss our results in terms of the two competing possibilities of a Kosterlitz-Thouless-Halperin-Nelson-Young two-stage melting scenario or a single first-order melting transition.
The DAPP-BQ in the Netherlands: Factor structure and relationship with basic personality dimensions.

After discarding eight items in the Dutch translation of Livesley’s DAPP-BQ that showed item-total correlations < 0.20 in a sample of 223 normal subjects, Cronbach’s α coefficients were calculated for the remaining items in the 18 scales of this instrument. The ‘Dutch’ α coefficients proved to be satisfactory. Furthermore, the Dutch DAPP-BQ scales were factor analyzed, retaining four factors. Three of these factors proved to be identical (Emotional Dysregulation and Dissocial) or nearly identical (Compulsivity) to the Canadian factors. However, the original factor Inhibition was not the same as the remaining Dutch factor Intimacy Problems. In a sample of 115 students, the estimated scores for the Dutch Dimensional Assessment of Personality Pathology-Basic Questionnaire (DAPP-BQ) factors were correlated with the scales of Van Kampen’s Four-Dimensional Personality Test. As expected, Emotional Dysregulation was found to correlate with Neuroticism, Dissocial with Insensitivity, and Compulsivity with Orderliness. The Intimacy Problems factor proved to be negatively correlated with Extraversion. The results obtained are embedded in the context of the evidence favoring a dimensional model of personality disorder. Furthermore, Livesley’s proposal that separate diagnostic criteria for the existence of a personality disorder must be formulated to supplement the assessment by means of the DAPP-BQ is critically discussed. In a clarifying article about the classification of personality disorders in DSM-III (APA, 1980) and DSM-III-R (American Psychiatric Association [APA], 1987), Livesley, Schroeder, Jackson, & Jang (1994) critically discuss three basic assumptions that underlie this classification. First, the assumption is criticized that normal and abnormal personality belong to qualitatively different domains, implying that personality disorder cannot be considered a variant of normal personality. Their second criticism, which is
A multidimensional measurement approach and analysis of children's motivation for reading, attributional style, and reading achievement

A MULTIDIMENSIONAL MEASUREMENT ApPROACH AND ANALYSIS OF CHILDREN'S MOTIVATION FOR READING, ATTRIBUTIONAL STYLE, AND READING Sara Michelle Fulmer Brock University, 2008 ACHIEVEMENT Advisor: Professor J. C. Frijters The present study investigates the usefulness of a multi-method approach to the measurement of reading motivation and achievement. A sample of 127 elementary and middle-school children aged 10 to 14 responded to measures of motivation, attributions, and achievement both longitudinally and in a challenging reading context. Novel measures of motivation and attributions were constructed, validated, and utilized to examine the relationship between ~ motivation, attributions, and achievement over a one-year period (Study I). The impact of classroom contexts and instructional practices was also explored through a study of the influence of topic interest and challenge on motivation, attributions, and persistence (Study II), as well as through interviews with children regarding motivation and reading in the classroom (Study III). Creation and validation of novel measures of motivation and attributions supported the use of a self-report measure of motivation in situation-specific contexts, and confirmed a three-factor structure of attributions for reading performance in both hypothetical and situation-specific contexts. A one-year follow up study of children's motivation and reading achievement demonstrated declines in all components of motivation beginning at age 10 through 12, and particularly strong decreases in motivation with the transition to middle school. Past perceived competence for reading predicted current achievement after controlling for past achievement, and showed the strongest relationships with reading-related skills in both elementary and middle school. Motivation and attributions were strongly related, and children with higher motivation
The Politics of Personality Disorder

This research tested the hypothesis that the gender distribution of personality disorders stems from the resemblance between each personality disorder and the role/role-stereotype of the status group for whom the disorder is prevalent. The first study found that undergraduates attributed descriptions of each personality disorder to the gender, social class, and marital status of the group that tends to receive that label; the second study found that the Sadistic and the Self-Defeating Personality Disorders of the DSM-IIIR were attributed to white males and middle-class females, respectively. It is suggested that personality disorders represent the roles/role-stereotypes of both genders.
Assessment of the Reliability and Validity of Student-Lecturer Evaluation Questionnaire: A Case of North West University

The study assessed the reliability and the validity of student-lecturer evaluation questionnaire used at the North West University in South Africa. The questionnaire was first used during the second semester of the year 2011 and was distributed to all students registered and present for lectures for piloting. This tool has not been tested for statistical significance before it could be implemented. It was however circulated on round robin to academics across the University for their inputs before it could be finalised. A total of 442 questionnaires distributed to students on a particular day of the year 2013 was analysed using Statistical Analysis Software version 9.3. Preliminary data analysis results provided enough evidence to conclude that the selected sample was adequate with the correlation matrix confirming the appropriateness of factor analysis. Cronbach’s alpha confirmed that individual and collective constructs in the questionnaire are reliable. Exploratory factor analysis results helped in rearranging the student-lecturer evaluation questionnaire collecting the 26 statements into four factors instead of the original five. The results obtained in this study will be presented to the academic development centre of the university and suggestions based on the findings about the questionnaire will also be given. The tool may also through the permission of the university be recommended to schools in the area. DOI: 10.5901/mjss.2014. v5n14p352
Epidemiology and Clinical Presentations of Respiratory Syncytial Virus Subgroups A and B Detected with Multiplex Real-Time PCR

Respiratory syncytial virus (RSV) is one of the most important pathogenic infections of children and requires in-depth research worldwide, and especially in developing countries. We used a novel multiplex real-time PCR to test 5483 patients (≤ 14 years old) hospitalized with respiratory illness in Guangzhou, China, over a 3-year period. Of these patients, 729 were positive for RSV-A (51.2%, 373/729) or RSV-B (48.8%, 356/729), but none was infected with both viruses. Two seasonal peaks in total RSV were detected at the changes from winter to spring and from summer to autumn. RSV-B was dominant in 2013 and RSV-A in 2015, whereas RSV-A and RSV-B cocirculated in 2014. The clinical presentations of 645 RSV-positive patients were analyzed. Bronchiolitis, dyspnea, coryza, vomiting, poor appetite, and diarrhea occurred more frequently in RSV-A-positive than RSV-B-positive patients, whereas chill, headache, myalgia, debility, and rash etc. were more frequent in RSV-B-positive than RSV-A-positive patients, suggesting specific clinical characteristics for RSV-A and RSV-B. Coinfectons with other pathogens were common and diverse. Bronchiolitis, fever (≥ 38°C), and poor appetite were more frequent in patients with single RSV infections than in coinfected patients, suggesting the key pathogenic activity of RSV. Analysis of the relationships between the comparative viral load and clinical presentations showed significant differences in bronchiolitis, fever (≥ 38°C), and rash etc. among patients with different viral loads. This study provides a novel rapid method for detecting RSV subgroups, and provides new insights into the epidemiology and clinical implications of RSV.
Minocycline Inhibition of Monocyte Activation Correlates with Neuronal Protection in SIV NeuroAIDS

Background Minocycline is a tetracycline antibiotic that has been proposed as a potential conjunctive therapy for HIV-1 associated cognitive disorders. Precise mechanism(s) of minocycline's functions are not well defined. Methods Fourteen rhesus macaques were SIV infected and neuronal metabolites measured by proton magnetic resonance spectroscopy (1H MRS). Seven received minocycline (4 mg/kg) daily starting at day 28 post-infection (pi). Monocyte expansion and activation were assessed by flow cytometry, cell traffic to lymph nodes, CD16 regulation, viral replication, and cytokine production were studied. Results Minocycline treatment decreased plasma virus and pro-inflammatory CD14+CD16+ and CD14loCD16+ monocytes, and reduced their expression of CD11b, CD163, CD64, CCR2 and HLA-DR. There was reduced recruitment of monocyte/macrophages and productively infected cells in axillary lymph nodes. There was an inverse correlation between brain NAA/Cr (neuronal injury) and circulating CD14+CD16+ and CD14loCD16+ monocytes. Minocycline treatment in vitro reduced SIV replication CD16 expression on activated CD14+CD16+ monocytes, and IL-6 production by monocytes following LPS stimulation. Conclusion Neuroprotective effects of minocycline are due in part to reduction of activated monocytes, monocyte traffic. Mechanisms for these effects include CD16 regulation, reduced viral replication, and inhibited immune activation.
Impoverishing experience: the problem of teacher education in England

Pre‐service teacher education in England has been essentially school‐based since 1992. The article offers a critique of this design from the perspective of a practitioner and researcher working in one of its most influential schemes. The fundamental problem described concerns an impoverished understanding of experience that underpins how beginning teachers are intended to learn in schools. The problem is not one of evaluating experience as adequate in terms of exemplary practices, but about the capacity within the teacher education system for critically examining the meaning of experience in order to develop professional knowledge. The article suggests that the ontological and epistemological dimensions of experience need to be brought into a dialogue if the potential of experiential learning for pre‐service teachers is to be realised.
Differential temporal and spatial expression of immediate early genes in retinal neurons after ischemia-reperfusion injury.

PURPOSE To investigate genes that are up- and downregulated in rat retinal ischemia-reperfusion injury systematically by using an oligonucleotide microarray system and to determine temporal and spatial expression changes of some genes that showed upregulation in the analysis. METHODS Retinal ischemia was induced in rats by increasing intraocular pressure to 110 mm Hg for 1 hour. Gene expression at 12 hours after reperfusion was compared with that in the control retina by using oligonucleotide microarrays that display a total of 8800 genes and expressed sequence tags (ESTs). Temporal and spatial expression changes of immediate early genes and cell-cycle-related genes were studied by using real-time polymerase chain reaction (PCR) and immunohistochemical methods. RESULTS At 12 hours after reperfusion, 135 genes and ESTs were found to be up- or downregulated. The upregulated genes were classified into seven groups: (1) immediate early genes; (2) cell-cycle-related genes; (3) stress-responsive protein genes; (4) cell-signaling protein genes; (5) cell-adhesion and cell surface protein genes; (6) genes for translation and protein turnover; and (7) genes for metabolism. Real-time PCR analyses showed peaks of Fra-1 expression at 6 hours after reperfusion, whereas those for c-Jun, Jun B, and cyclin D1 were at 24 hours. Fra-1 and Jun B immunoreactivities were found in Müller cells, whereas c-Jun and cyclin D1 immunoreactivities were found in apoptotic retinal neurons. CONCLUSIONS Gene expression changes after a retinal ischemia-reperfusion injury were profiled by using an oligonucleotide microarray system. Seven groups of genes were found to be upregulated by the injury. Among the immediate early genes, Fra-1 and Jun B immunoreactivities were found in Müller cells whereas c-Jun and cyclin D1 immunoreactivities were found in apoptotic retinal neurons.