Miracle-dz/UniFAR-FTUs huggingface dataset:
Objective Evaluation of Vergence Disorders and a Research-Based Novel Method for Vergence Rehabilitation

Purpose We performed video-oculography to evaluate vergence eye movement abnormalities in students diagnosed clinically with vergence disorders. We tested the efficiency of a novel rehabilitation method and evaluated its benefits with video-oculography cross-correlated with clinical tests and symptomatology. Methods A total of 19 students (20–27 years old) underwent ophthalmologic, orthoptic examination, and a vergence test coupled with video-oculography. Eight patients were diagnosed with vergence disorders with a high symptomatology score (CISS) and performed a 5-week session of vergence rehabilitation. Vergence and rehabilitation tasks were performed with a trapezoid surface of light emitting diodes (LEDs) and adjacent buzzers (US 8851669). We used a novel Vergence double-step (Vd-s) protocol: the target stepped to a second position before the vergence movement completion. Afterward the vergence test was repeated 1 week and 1 month later. Results Abnormally increased intertrial variability was observed for many vergence parameters (gain, duration, and speed) for the subjects with vergence disorders. High CISS scores were correlated with variability and increased latency. After the Vd-s, variability of all parameters dropped to normal or better levels. Moreover, the convergence and divergence latency diminished significantly to levels better than normal; benefits were maintained 1 month after completion of Vd-s. CISS scores dropped to normal level, which was maintained up to 1 year. Conclusions and Translational Relevance: Intertrial variability is the major marker of vergence disorders. The Vd-s research-based method leads to normalization of vergence properties and lasting removal of symptoms. The efficiency of the method is due to the spatiotemporal parameters of repetitive trials that stimulate neural plasticity.
Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations

The present study aimed to determine the expression of erythropoietin (EPO) and the EPO receptor (EPOR) in spiral ganglion neurons (SGNs) in the inner ear of rats of various ages, and the associated neuronal apoptosis and hearing alterations. A total of 15 healthy rats (n=30 ears), were divided into three groups: i) A nominated infant group at post-natal day (PND) 12–14, ii) an adult group at PND 60 and iii) a 3-year postnatal aged group. Auditory brainstem response (ABR) measurements were performed on all rats. EPO and EPOR expression in the inner ear was detected by immunohistochemistry. In situ terminal deoxynucleotidyl transferase dUTP nick end labeling assays were performed to detect the apoptosis of SGNs. The average hearing thresholds of the ABR (decibels above normal hearing level) were 5.625±4.955 in the infant, 15.000±8.498 in the adult and 23.500±13.134 in the aged groups. Hearing thresholds for aged and adult rats increased significantly compared with infant rats. However, the difference in latencies of peak I was not significant (P>0.05). EPO in SGNs was detected during different developmental periods without significant alterations, but were reduced compared with Corti's organ or the stria vascularis. EPOR expression increased significantly from infant to adult stage, and this increased expression was maintained in the aged group. An age-associated increase in the apoptosis of SGNs was detected in all three groups (P=0.0347). The potential neuroprotective effects of EPO in SGNs may not be revealed during the aging process under natural conditions, and may be associated with spontaneous neuronal apoptosis and consequently, hearing diminution. However, the age-associated increase in EPOR in SGNs may exert a role in neuroprotection when necessary, for example in presbycusis.
Focal Adhesion Kinase, a Downstream Mediator of Raf-1 Signaling, Suppresses Cellular Adhesion, Migration, and Neuroendocrine Markers in BON Carcinoid Cells

We have recently reported that activation of the Raf-1/mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase 1/2 (MEK1/2)/ERK1/2 signaling cascade in gastrointestinal carcinoid cell line (BON) alters cellular morphology and neuroendocrine phenotype. The mechanisms by which Raf-1 mediates these changes in carcinoid cells are unclear. Here, we report that activation of the Raf-1 signaling cascade in BON cells induced the expression of focal adhesion kinase (FAK) protein, suppressed the production of neuroendocrine markers, and resulted in significant decreases in cellular adhesion and migration. Importantly, inactivation of MEK1/2 by 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene or abolition of FAK induction in Raf-1–activated BON cells by targeted siRNA led to reversal of the Raf-1–mediated reduction in neuroendocrine markers and cellular adhesion and migration. Phosphorylation site-specific antibodies detected the phosphorylated FAKTyr407, but not FAKTyr397, in these Raf-1–activated cells, indicating that FAKTyr407 may be associated with changes in the neuroendocrine phenotype. Overexpression of constitutively active FAK plasmids (wild-type FAK or FAKTyr397 mutant) into BON cells reduced neuroendocrine markers, whereas the FAKTyr407 mutant plasmid did not show any decrease in the levels of neuroendocrine markers, indicating that phosphorylation of FAK at the Tyr407 residue may be important for these effects. Our results showed for the first time that FAK is an essential downstream effector of the Raf-1/MEK1/2/ERK1/2 signaling cascade and negatively regulated the neuroendocrine and metastatic phenotype in BON cells. Mol Cancer Res; 8(5); 775–82. ©2010 AACR.
Fast Visual Odometry for 3-D Range Sensors

This paper presents a new dense method to compute the odometry of a free-flying range sensor in real time. The method applies the range flow constraint equation to sensed points in the temporal flow to derive the linear and angular velocity of the sensor in a rigid environment. Although this approach is applicable to any range sensor, we particularize its formulation to estimate the 3-D motion of a range camera. The proposed algorithm is tested with different image resolutions and compared with two state-of-the-art methods: generalized iterative closest point (GICP) [1] and robust dense visual odometry (RDVO) [2]. Experiments show that our approach clearly overperforms GICP which uses the same geometric input data, whereas it achieves results similar to RDVO, which requires both geometric and photometric data to work. Furthermore, experiments are carried out to demonstrate that our approach is able to estimate fast motions at 60 Hz running on a single CPU core, a performance that has never been reported in the literature. The algorithm is available online under an open source license so that the robotic community can benefit from it.
Quantifying Taste: Findings from a survey on media and taste among teenagers from six high schools in Cape Town

Recent studies suggest that young South Africans increasingly use references to popular culture, such as music and fashion, in making racial distinctions. This leads to a reinterpretation of race categories but not to the demise of the importance of race in the way adolescents see themselves and others. It is argued in this paper that the link between race and popular culture is creating and maintaining racialised taste patterns, which in turn causes adolescents to develop racialised media preferences. In other words someone's race, in terms of self-definition, is not only a strong predictor for someone's taste in popular culture (in this paper exemplified by music taste) and media preference (here restricted to radio, television and music television) but also one can find a strong relationship between certain music tastes and media preferences. This argument is supported by the statistical analysis of data from a survey with schoolchildren from six public high schools in the Greater Cape Town Metropolitan Area. The results show that among the participants significant relationships exist between race, music taste and preferences for certain radio, television and music television stations as well as between race and certain music genres. These findings are being discussed against the background of an increasingly segmented mediascape and the question for the attainability of a collective South African identity. It is concluded that racialised media preferences might encourage media producers to target audiences based on race, thus promoting racial difference rather than cross-racial similarities or commonalities.
Robotic-assisted laparoscopic mesh sacrocolpopexy

The current ‘gold standard’ surgical repair for apical prolapse is the abdominal mesh sacrocolpopexy. Use of a robotic-assisted laparoscopic surgical approach has been demonstrated to be feasible as a minimally invasive approach and is gaining popularity amongst pelvic floor reconstructive surgeons. Although outcome data for robotic-assisted sacrocolpopexy (RASC) is only just emerging, several small series have demonstrated anatomic and functional outcomes, as well as complication rates, comparable to those reported for open surgery. The primary advantages thus far for RASC over open surgery include decreased blood loss and shorter hospital stay.
High-Quality Draft Genome Sequence of Desulfovibrio carbinoliphilus FW-101-2B, an Organic Acid-Oxidizing Sulfate-Reducing Bacterium Isolated from Uranium(VI)-Contaminated Groundwater

ABSTRACT Desulfovibrio carbinoliphilus subsp. oakridgensis FW-101-2B is an anaerobic, organic acid/alcohol-oxidizing, sulfate-reducing δ-proteobacterium. FW-101-2B was isolated from contaminated groundwater at The Field Research Center at Oak Ridge National Lab after in situ stimulation for heavy metal-reducing conditions. The genome will help elucidate the metabolic potential of sulfate-reducing bacteria during uranium reduction.
Human-in-the-loop optimisation: Mixed initiative grasping for optimally facilitating post-grasp manipulative actions

This paper addresses the problem of mixed initiative, shared control for master-slave grasping and manipulation. We propose a novel system, in which an autonomous agent assists a human in teleoperating a remote slave arm/gripper, using a haptic master device. Our system is designed to exploit the human operator's expertise in selecting stable grasps (still an open research topic in autonomous robotics). Meanwhile, a-priori knowledge of: i) the slave robot kinematics, and ii) the desired post-grasp manipulative trajectory, are fed to an autonomous agent which transmits force cues to the human, to encourage maximally manipulable grasp pose selections. Specifically, the autonomous agent provides force cues to the human, during the reach-to-grasp phase, which encourage the human to select grasp poses which maximise manipulation capability during the post-grasp object manipulation phase. We introduce a task-oriented velocity manipulability cost function (TOV), which is used to identify the maximum kinematic capability of a manipulator during post-grasp motions, and feed this back as force cues to the human during the pre-grasp phase. We show that grasps which minimise TOV result in significantly reduced control effort of the manipulator, compared to other feasible grasps. We demonstrate the effectiveness of our approach by experiments with both real and simulated robots.
Role of competitive interactions in the postnatal development of X and Y retinogeniculate axons

The cat's retinogeniculate pathway is largely composed of X and Y axons, which represent two distinct neuronal streams organized in parallel. Our earlier data, summarized in the previous paper, suggest that the postnatal development of retinogeniculate axon arbors is characterized by competitive interactions between the X and Y axons. Thus, during development, X arbors in lamina A or A1 are initially broad or exuberant before the Y arbors begin to develop adultlike arbors; the X arbors then shrink to their adult form as the Y arbors grow and establish their mature complement of connections; monocular lid suture prevents the rapid growth of Y arbors, which in turn prevents the pruning of X arbors; and monocular enucleation at birth allows X arbors from the remaining eye to retain their exuberance although completely confined to their appropriate lamina A or A1, whereas the Y arbors develop aberrant extensions into adjacent, previously denervated laminae. We now provide additional evidence for the role of competition between retinogeniculate X and Y axons during development. The addition of visual deprivation by lid suture of the remaining eye to monocular enucleation at birth causes no apparent change in the morphology of X arbors in laminae A and A1. In contrast, the Y arbors of such cats continue to form extensive translaminar sprouts in the previously denervated laminae despite severely reduced terminations in the lamina A or A1 normally innervated by the remaining eye. We interpret these new data, in conjunction with our earlier data, as follows. If retinogeniculate X and Y arbors compete for synaptic space during postnatal development, terminations of Y axon can be affected by lid suture only in geniculate laminae where terminations of X axons are also present. Thus, Y axon arbors are severely reduced in deprived lamina A or A1 following lid suture whether or not the other eye is removed. Where X arbors are not present, such as in lamina C or the laminae inappropriate for the remaining eye after removal of the other, the lid suture has no obvious effect on development of the Y arbors.
Dissolution of Arsenic Minerals Mediated by Dissimilatory Arsenate Reducing Bacteria: Estimation of the Physiological Potential for Arsenic Mobilization

The aim of this study was characterization of the isolated dissimilatory arsenate reducing bacteria in the context of their potential for arsenic removal from primary arsenic minerals through reductive dissolution. Four strains, Shewanella sp. OM1, Pseudomonas sp. OM2, Aeromonas sp. OM4, and Serratia sp. OM17, capable of anaerobic growth with As (V) reduction, were isolated from microbial mats from an ancient gold mine. All of the isolated strains: (i) produced siderophores that promote dissolution of minerals, (ii) were resistant to dissolved arsenic compounds, (iii) were able to use the dissolved arsenates as the terminal electron acceptor, and (iii) were able to use copper minerals containing arsenic minerals (e.g., enargite) as a respiratory substrate. Based on the results obtained in this study, we postulate that arsenic can be released from some As-bearing polymetallic minerals (such as copper ore concentrates or middlings) under reductive conditions by dissimilatory arsenate reducers in indirect processes.
Empowerment, motivation, and medical adherence (EMMA): the feasibility of a program for patient-centered consultations to support medication adherence and blood glucose control in adults with type 2 diabetes

Purpose To explore the feasibility of a research-based program for patient-centered consultations to improve medical adherence and blood glucose control in patients with type 2 diabetes. Patients and methods The patient-centered empowerment, motivation, and medical adherence (EMMA) consultation program consisted of three individual consultations and one phone call with a single health care professional (HCP). Nineteen patients with type 2 diabetes completed the feasibility study. Feasibility was assessed by a questionnaire-based interview with patients 2 months after the final consultation and interviews with HCPs. Patient participation was measured by 10-second event coding based on digital recordings and observations of the consultations. Results HCPs reported that EMMA supported patient-centered consultations by facilitating dialogue, reflection, and patient activity. Patients reported that they experienced valuable learning during the consultations, felt understood, and listened to and felt a trusting relationship with HCPs. Consultations became more person-specific, which helped patients and HCPs to discover inadequate diabetes self-management through shared decision-making. Compared with routine consultations, HCPs talked less and patients talked more. Seven of ten dialogue tools were used by all patients. It was difficult to complete the EMMA consultations within the scheduled time. Conclusion The EMMA program was feasible, usable, and acceptable to patients and HCPs. The use of tools elicited patients’ perspectives and facilitated patient participation and shared decision-making.
Learning Operational Space Control

While operational space control is of essential importance for robotics and well-understood from an analytical point of view, it can be prohibitively hard to achieve accurate control in face of modeling errors, which are inevitable in complex robots, e.g., humanoid robots. In such cases, learning control methods can offer an interesting alternative to analytical control algorithms. However, the resulting learning problem is ill-defined as it requires to learn an inverse mapping of a usually redundant system, which is well known to suffer from the property of non-convexity of the solution space, i.e., the learning system could generate motor commands that try to steer the robot into physically impossible configurations. A first important insight for this paper is that, nevertheless, a physically correct solution to the inverse problem does exit when learning of the inverse map is performed in a suitable piecewise linear way. The second crucial component for our work is based on a recent insight that many operational space controllers can be understood in terms of a constraint optimal control problem. The cost function associated with this optimal control problem allows us to formulate a learning algorithm that automatically synthesizes a globally consistent desired resolution of redundancy while learning the operational space controller. From the view of machine learning, the learning problem corresponds to a reinforcement learning problem that maximizes an immediate reward and that employs an expectation-maximization policy search algorithm. Evaluations on a three degrees of freedom robot arm illustrate the feasibility of the suggested approach.
Predominance of Nonatherosclerotic Internal Elastic Lamina Calcification in the Intracranial Internal Carotid Artery

Background and Purpose— Calcification of the intracranial internal carotid artery (iICA) is an independent risk factor for stroke. These calcifications are generally seen as manifestation of atherosclerosis, but histological investigations are limited. The aim of this study is to determine whether calcifications in the iICA are present in atherosclerotic plaques, or in other parts of the arterial wall. Methods— Thirty-nine iICAs were histologically assessed, using digital microscopy to quantify the amount of calcification in the different layers of the arterial wall. Results— Calcifications were found in the intima, around the internal elastic lamina and in the medial layer of the arterial wall. In 71% of the arteries, internal elastic lamina calcification contributed most to the total calcified cross-sectional surface area. Internal elastic lamina calcification was unrelated to the occurrence of atherosclerotic intimal lesions. Intimal calcifications were most often associated with atherosclerotic lesions, but also many noncalcified atherosclerotic lesions were found. Conclusions— In the iICA, calcifications are predominantly present around the internal elastic lamina, suggesting that this nonatherosclerotic type of calcification contributes to the previously observed increased risk of stroke in patients with iICA calcifications.
Model-Driven Generation of Web Applications in UWE

Model-driven engineering (MDE) techniques address rapid changes in Web languages and platforms by lifting the abstraction level from code to models. On the one hand models are transformed for model elaboration and translation to code; on the other hand models can be executable. We demonstrate how both approaches are used in a complementary way in UML-based Web Engineering (UWE). Rule-based transformations written in ATL are defined for all model-to-model transitions, and model-to-code transformations pertaining to content, navigation and presentation. An UWE run-time environment allows for direct execution of UML activity models of business processes.
“Does he need help or can he help himself?” Preschool children’s expectations about others’ instrumental helping versus self-helping

In the present study, we investigated a total of fifty-one 3.5-, 4.5-, and 5.5-year-old children’s expectations about another person’s helping behaviors. We asked children to complete a story in which one person failed to complete his goal (e.g., because an object was misplaced or put out of his reach) while the other person observed the event. We asked whether the children expected the other person to help the protagonist or whether they expected the protagonist to help himself. Children of 3.5 years expected the other person to provide help in the majority of trials. In contrast, the older children were equally likely to predict that the other person would help the protagonist or the protagonist would help himself.
Digital Preservation: Architecture and Technology for Trusted Digital Repositories

Abstract Developing preservation processes for a trusted digital repository will require the integration of new methods, policies, standards, and technologies. Digital repositories should be able to preserve electronic materials for periods at least comparable to existing preservation methods. Modern computing technology in general is barely fifty years old and few of us have seen or used digital objects that are more than ten years old. While traditional preservation practices are comparatively well-developed, lack of experience and lack of consensus raise some questions about how we should proceed with digital-based preservation processes. Can we preserve a digital object for at least one-hundred years? Can we answer questions such as “Is this object the digital original”? or “How old is this digital object”? What does it mean to be a trusted repository of digital materials? A basic premise of this article is that there are many technologies available today that will help us build trust in a digital preservation process and that these technologies can be readily integrated into an operational digital preservation framework.