Miracle-dz/UniFAR-FTUs huggingface dataset:
Free Radical‐Generated Neurotoxicity of 6‐Hydroxydopamine

Abstract: Albino rats were lesioned bilaterally with 6‐hydroxydopamine (6‐OHDA) hydrochloride (4 µg/µl, dissolved in saline with 0.1% ascorbic acid) into the striatum, and 72 h after the injection, levels of lipid peroxidation, GSH, superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), lipid class, membrane fluidity, and intracellular calcium concentrations were studied and the results were compared with those in the sham‐operated controls. The malonaldialdehyde level and the level of conjugated dienes were increased by 43 and 40%, respectively, in corpus striatum, and GSH, SOD, and GSH‐Px levels were decreased (24–30%) following 6‐OHDA treatment. Total phospholipid content was also decreased (18%), whereas cholesterol content remained unaffected. Among the different phospholipids only phosphatidylcholine and phosphatidylinositol were decreased in level. Membrane fluidity was decreased (23%), whereas the intracellular calcium concentration was elevated (100%) in corpus striatum compared with control rats. The results suggest that these alterations in membrane‐related events by 6‐OHDA could be due to free radical generation.
Decomposing Discussion Forums using User Roles

Discussion forums are a central part of Web 2.0 and Enterprise 2.0 infrastructures. The health and sustainability of forums is dependent on the information exchange behaviour of its members. Such behaviour needs to be better understood and characterised so that forums can be better managed, new services delivered and opportunities and risks detected. In this paper, we present a method for analysing user communication roles in discussion forums. We analyse the composition of several forums from a medium-sized national bulletin board in terms of these roles, demonstrating similarities between forums based on underlying user behaviour rather than topic. We suggest that analysing the evolution of role composition is an important step in developing a predictive model of forum health.
TASI Lectures on Electroweak Symmetry Breaking from Extra Dimensions

This is a pedagogical introduction into the possible uses and effects of extra dimensions in electroweak (TeV scale) physics, and in particular to models of electroweak symmetry breaking via boundary conditions ("higgsless models"). It is self contained: all the aspects of extra dimensional and electroweak physics used here are reviewed, before we apply these concepts to higgsless models. In the first lecture gauge theories in an extra dimension and on an interval are discussed. In the second lecture we describe the basic structure of higgsless models, while in the third lecture we discuss fermions in extra dimensions and the inclusion of fermions into higgsless models. The final lecture is devoted to the issue of electroweak precision observables in theories beyond the standard model and its applications to extra dimensional theories and in particular the higgsless models.
Connection Overload? A Cross Cultural Study of the Consequences of Social Media Connection

Both positive and negative impacts of specific social media channels have been identified, but their cumulative impacts across media and across cultures have not been examined. A connection overload path model was developed from data gathered in Ireland, the United States, and Korea. The magnitude of connection demands reduced negative affect, while connection habits reduced negative outcomes and negative affect. Difficulties controlling connection habits were related to negative impacts on important life activities, stress, and affect. Cultural differences were interpreted through the individualism-collectivism framework. Collectivists may be buffered from mechanisms that can adversely impact psychological well-being.
Impact of Early Nutrition on Body Composition in Children Aged 9.5 Years Born with Extremely Low Birth Weight

To evaluate body composition, metabolism and growth as well as their interaction with early nutrition in former extremely low birth weight infants (ELBW), we assessed qualitative and quantitative nutritional intake during initial hospitalization and infantile growth parameters in 61 former ELBW infants with a birth weight <1000 g. In two follow-up exams, physical and biochemical development were measured at 5.7 and at 9.5 years. At the second follow-up, in addition to biochemical reassessment, body composition was analyzed by dual-energy x-ray absorptiometry (DEXA). Protein intake between birth and discharge was associated with weight gain in the first six months of life (r = 0.51; p < 0.01). Weight catch-up preceded height catch-up. Protein intake in early infancy correlated highly significantly with abdominal fat mass (r = 0.49; p < 0.05), but not with lean body mass at 9.5 years (r = 0.30; not significant (n.s.). In contrast to nutrient intake, birth weight was associated with lean body mass (r = 0.433; p < 0.001). Early protein and carbohydrate intake were associated with high-density lipoprotein (HDL)-cholesterol, and early catch-up growth correlated with fasting insulin at follow-up. Stepwise linear regression demonstrated that protein intake predicted fat mass (p < 0.05), whereas only gender and birth weight standard deviation score (SDS) contributed significantly to lean body mass variation (p < 0.05). Our results suggest an important impact of early nutrient intake on body composition and metabolism in later childhood in ELBW children.
Progressive cis‐inhibition of telomerase upon telomere elongation

In yeast, the constant length of telomeric DNA results from a negative regulation of telomerase by the telomere itself. Here we follow the return to equilibrium of an abnormally shortened telomere. We observe that telomere elongation is restricted to a few base pairs per generation and that its rate decreases progressively with increasing telomere length. In contrast, in the absence of telomerase or in the presence of an over‐elongated telomere, the degradation rate linked to the succession of generations appears to be constant, i.e. independent of telomere length. Together, these results indicate that telomerase is gradually inhibited at its site of action by the elongating telomere. The implications of this finding for the dynamics of telomere length regulation are discussed in this study.
T Cell Receptor (TCR) Antagonism without a Negative Signal: Evidence from T Cell Hybridomas Expressing Two Independent TCRs

Antagonist peptides inhibit T cell responses by an unknown mechanism. By coexpressing two independent T cell receptors (TCRs) on a single T cell hybridoma, we addressed the question of whether antagonist ligands induce a dominant-negative signal that inhibits the function of a second, independent TCR. The two receptors, Vα2Vβ5 and Vα2Vβ10, restricted by H-2Kb and specific for the octameric peptides SIINFEKL and SSIEFARL, respectively, were coexpressed on the same cell. Agonist stimulation demonstrated that the two receptors behaved independently with regard to antigen-induced TCR downregulation and intracellular biochemical signaling. The exposure of one TCR (Vα2Vβ5) to antagonist peptides could not inhibit a second independent TCR (Vα2Vβ10) from responding to its antigen. Thus, our data clearly demonstrate that these antagonist ligands do not generate a dominant-negative signal which affects the responsiveness of the entire cell. In addition, a kinetic analysis showed that even 12 h after engagement with their cognate antigen and 10 h after reaching a steady-state of TCR internalization, T cells were fully inhibited by the addition of antagonist peptides. The window of susceptibility to antagonist ligands correlated exactly with the time required for the responding T cells to commit to interleukin 2 production. The data support a model where antagonist ligands can competitively inhibit antigenic peptides from productively engaging the TCR. This competitive inhibition is effective during the entire commitment period, where sustained TCR engagement is essential for full T cell activation.
Distribution of Carbonic Anhydrase Isozyme VI in the Developing Bovine Parotid Gland

The distribution of bovine carbonic anhydrase isozyme VI (CA-VI), purified from bovine saliva, was studied immunohistochemically using antiserum against bovine CA-VI in bovine parotid glands during fetal and postnatal development. A weak expression of CA-VI in undifferentiated epithelial cells and ductal cells was observed in a 4- to 5-month-old fetus with a 26-cm crown-rump length. The reaction in both acinar and ductal cells subsequently persisted during late gestation and birth. Although anti-CA-VI reactivity was still seen in both regions immediately following birth, the reactivity had almost completely disappeared from most duct segments by 1 month following birth. Changes in the localization and time-dependent expression of the isozyme in parotid glands may reflect changes in the biological function of structurally closely related isozymes.
The representation of Islam in British museums

In addressing the subject of the representation of Islam in museums, this work undertakes to examine both its production and consumption. The production of representation and the creation of identity are achieved in museums through the medium of the display of material, whilst consumption occurs through the medium of visiting and the meaning made by visitors. In order to evaluate such production displays of Islamic material in museums are the subject of critical analysis. This research has a qualitative element and seeks to tap into the perceptions of museum visitors of current museum displays. Given the role played by museums in the construction of identity the questions underpinning this are firstly, what are the messages they receive about the world of Islam and secondly, what do these displays say about the Islamic world past and present?
The Psychobiology of Gene Expression: Neuroscience and Neurogenesis in Hypnosis and the Healing Arts

The new neuroscience discoveries about enriching life experiences, neurogenesis, and gene expression are poised to profoundly expand our understanding of psychotherapy and the holistic healing arts. We are just beginning to learn how the brain, the body, and our genes interact in ordinary everyday life to create our lives. Here, acclaimed author and pioneer of new approaches to mindbody communication Ernest Rossi introduces the new science of psychosocial genomics and explores how it will profoundly change our understanding of the pathways of communication among mind, body, and spirit. Integrating modern molecular medicine with traditional holistic healing art and spiritual rites, Rossi documents dramatically new approaches to optimize creativity in psychotherapy and therapeutic hypnosis with both individuals and groups. Part I reviews significant leading-edge neuroscience research on the psychobiology of gene expression and neurogenesis that leads to a new vision of the role of consciousness and creativity in the humanities and the healing arts. Part II explores how to creatively facilitate the psychodynamics of gene expression, neurogenesis, and healing in therapeutic hypnosis, psychotherapy, and human relationships in general. The Psychobiology of Gene Expression illustrates, step-by-step, how to facilitate the natural four-stage creative process on all levels from mind to molecule in our daily work of building a better brain. The book demonstrates how we can use our consciousness and our perception of free will to co-create ourselves in cooperation with nature. Rossi proposes practical approaches to optimize the natural cycles of gene expression in normal consciousness, sleep, dreaming, meditation, and the arts of daily living that are experienced by everyone. A case study spanning two chapters, containing dialog and explanatory commentary, brings the author's work to life and gives readers a deeper appreciation of its clinical application. Rossi's lucid writing style and vivid illustrations inspire this text with a new vision of the creative arts, humanities, and culture in facilitating the optimal development of health, performance, and consciousness.
Tomographic errors from wave front healing: more than just a fast bias

Wave front healing, in which diffractions interfere with directly travelling waves causing a reduction in recorded traveltime delays, has been postulated to cause a bias towards faster estimated earth models. This paper reviews the theory from the mathematical physics community that explains the properties of diffractions and applies it to a suite of increasingly complicated numerical examples. We focus in particular on the elastic case and on the differences between P and S healing. We find that rather than introducing a systemic fast bias, wave front healing gives a more complicated bias in the results of traveltime tomography, with fast anomalies even manifesting themselves as slow anomalies in some situations. Of particular interest, we find that a negative correlation between the bulk and shear or compressional velocities may result to a large extend from healing.
Reciprocal Interactions between Medial Septum and Hippocampus in Theta Generation: Granger Causality Decomposition of Mixed Spike-Field Recordings

The medial septum (MS) plays an essential role in rhythmogenesis in the hippocampus (HIPP); theta-rhythmic bursts of MS neurons are believed to drive theta oscillations in rats’ HIPP. The MS theta pacemaker hypothesis has solid foundation but the MS-hippocampal interactions during different behavioral states are poorly understood. The MS and the HIPP have reciprocal connections and it is not clear in particular what role, if any, the strong HIPP to MS projection plays in theta generation. To study the functional interactions between MS and HIPP during different behavioral states, this study investigated the relationship between MS single-unit activity and HIPP field potential oscillations during theta states of active waking and REM sleep and non-theta states of slow wave sleep (SWS) and quiet waking (QW), i.e., sleep-wake states that comprise the full behavioral repertoire of undisturbed, freely moving rats. We used non-parametric Granger causality (GC) to decompose the MS-HIPP synchrony into its directional components, MS→HIPP and HIPP→MS, and to examine the causal interactions between them within the theta frequency band. We found a significant unidirectional MS→HIPP influence in non-theta states which switches to bidirectional theta drive during theta states with MS→HIPP and HIPP→MS GC being of equal magnitude. In non-theta states, unidirectional MS→HIPP influence was accompanied by significant MS-HIPP coherence, but no signs of theta oscillations in the HIPP. In theta states of active waking and REM sleep, sharp theta coherence and strong theta power in both structures was associated with a rise in HIPP→MS to the level of the MS→HIPP drive. Thus, striking differences between waking and REM sleep theta states and non-theta states of SWS and QW were primarily observed in activation of theta influence carried by the descending HIPP→MS pathway associated with more regular rhythmic bursts in the MS and sharper MS→HIPP GC spectra without a significant increase in MS→HIPP GC magnitude. The results of this study suggest an essential role of descending HIPP to MS projections in theta generation.
The role of parity status on cigarette smoke-induced modulation of anti-tumor immune mechanisms

Epidemiologic studies indicate that women who smoke cigarettes are more likely to experience adverse reproductive and immunological health effects. Despite these facts, 20–30% of American women still smoke during their reproductive years. As little is known of the relationship between smoking and the immune response during pregnancy, an investigation was conducted using parous and non-parous (virgin) B6C3F1 mice to investigate what role (if any) parity status had on cigarette smoke (CS) induced effects on immune functions important in surveillance against developing tumors. Pregnant mice were exposed to CS for 5 d/wk ( 4 hr/d) from gestational day 4 to parturition; virgin mice were exposed for an equivalent amount of time. Smoke- and parity-associated alterations in pulmonary histology and lung inflammation, along with tumor cell host resistance, and cytotoxic T-lymphocyte (CTL) activity were examined either 24- 48 hr or 5 wk post-exposure/parturition; in the parous mice, gestational parameters were also evaluated. Exposure to CS significantly increased tumor susceptibility in virgin mice first injected with EL4 lymphoma cells at the 5 wk post-exposure timepoint; tumor incidence began to increase in smoke-exposed virgin mice as early as 24– 48 hr post-exposure. Pregnancy itself increased tumor incidence in mice injected with EL4 cells 24– 48 hr after birth, but this effect then dissipated over 5 wk to levels seen in virgin mice. When EL4 injections were first performed at either timepoint in CS-exposed parous mice, the tumor incidence was not significantly different from that in the air-exposed parity-matched controls. CTL activity in CS-exposed parous mice was significantly increased from both nulliparous groups as well as from the parous air control mice examined 5 wk post-exposure. Results suggest that exposure to CS throughout gestation could act in combination with pregnancy-associated changes to up-regulate immune responses, potentially compromising fetal tolerance.
Top-Down Visual Saliency Guided by Captions

Neural image/video captioning models can generate accurate descriptions, but their internal process of mapping regions to words is a black box and therefore difficult to explain. Top-down neural saliency methods can find important regions given a high-level semantic task such as object classification, but cannot use a natural language sentence as the top-down input for the task. In this paper, we propose Caption-Guided Visual Saliency to expose the region-to-word mapping in modern encoder-decoder networks and demonstrate that it is learned implicitly from caption training data, without any pixel-level annotations. Our approach can produce spatial or spatiotemporal heatmaps for both predicted captions, and for arbitrary query sentences. It recovers saliency without the overhead of introducing explicit attention layers, and can be used to analyze a variety of existing model architectures and improve their design. Evaluation on large-scale video and image datasets demonstrates that our approach achieves comparable captioning performance with existing methods while providing more accurate saliency heatmaps. Our code is available at visionlearninggroup.github. io/caption-guided-saliency/.
Export Markets and Labor Allocation in a Low-Income Country

We study the effects of a positive export shock on labor allocation between the informal, microenterprise sector and the formal firm sector in a low-income country. The United States-Vietnam Bilateral Trade Agreement led to large reductions in US tariffs on Vietnamese exports. We find that the share of manufacturing workers in Vietnam in the formal sector increased by 5 percentage points in response to the US tariff reductions. The reallocation was greater for workers in more internationally integrated provinces and for younger cohorts. We estimate the gap in labor productivity within manufacturing across the informal and formal sectors. This gap and the aggregate labor productivity gain from the export-induced reallocation of workers across the two sectors are reduced when we account for worker heterogeneity, measurement error, and differences in labor intensity of production. (JEL F16, J24, O14, O17, O19, P23, P33)
Deregulating labour markets: how robust is the analysis of recent IMF working papers?

In a series of recent IMF papers, Bernal-Verdugo, Furceri and Guillaume (2012a,2012b), Crivelli, Furceri and Toujas-Bernate (2012), and Furceri (2012) report finding strong evidence that more flexible labour markets are negatively associated with unemployment and positively associated with employment elasticities, and that large-scale reforms of labour market institutions towards flexibility may help reduce unemployment. This paper examines the reliability of the data and of the methodology used in these papers. It reports serious flaws both in the data and in the way they are used, such as employing the suspended World Bank Employing Workers Indicators, or interpreting methodological breaks in series as reform processes. When these breaks in series are accounted for, the majority of reforms identified in Bernal-Verdugo, Furceri and Guillaume (2012a) cannot be replicated. Moreover, the methodology of identifying reforms from the data employed in the latter paper does not capture actual reform processes and ignores the scope and the size of the reforms. Taken together, our findings call into question most of the empirical results of these papers and policy advice based on them.
Effects of grazing on grassland soil carbon: a global review

Soils of grasslands represent a large potential reservoir for storing CO2, but this potential likely depends on how grasslands are managed for large mammal grazing. Previous studies found both strong positive and negative grazing effects on soil organic carbon (SOC) but explanations for this variation are poorly developed. Expanding on previous reviews, we performed a multifactorial meta‐analysis of grazer effects on SOC density on 47 independent experimental contrasts from 17 studies. We explicitly tested hypotheses that grazer effects would shift from negative to positive with decreasing precipitation, increasing fineness of soil texture, transition from dominant grass species with C3 to C4 photosynthesis, and decreasing grazing intensity, after controlling for study duration and sampling depth. The six variables of soil texture, precipitation, grass type, grazing intensity, study duration, and sampling depth explained 85% of a large variation (±150 g m−2 yr−1) in grazing effects, and the best model included significant interactions between precipitation and soil texture (P = 0.002), grass type, and grazing intensity (P = 0.012), and study duration and soil sampling depth (P = 0.020). Specifically, an increase in mean annual precipitation of 600 mm resulted in a 24% decrease in grazer effect size on finer textured soils, while on sandy soils the same increase in precipitation produced a 22% increase in grazer effect on SOC. Increasing grazing intensity increased SOC by 6–7% on C4‐dominated and C4–C3 mixed grasslands, but decreased SOC by an average 18% in C3‐dominated grasslands. We discovered these patterns despite a lack of studies in natural, wildlife‐dominated ecosystems, and tropical grasslands. Our results, which suggest a future focus on why C3 vs. C4‐dominated grasslands differ so strongly in their response of SOC to grazing, show that grazer effects on SOC are highly context‐specific and imply that grazers in different regions might be managed differently to help mitigate greenhouse gas emissions.