Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlations between promoter activity and its nucleotide positions in spacing region

Transcription is one of the essential processes for cells to read genetic information encoded in genes, which is initiated by the binding of RNA polymerase to related promoter. Experiments have found that the nucleotide sequence of promoter has great influence on gene expression strength, or promoter activity. In synthetic biology, one interesting question is how we can synthesize a promoter with given activity, and which positions of promoter sequence are important for determining its activity. In this study, based on recent experimental data, correlations between promoter activity and its sequence positions are analyzed by various methods. Our results show that, except nucleotides in the two highly conserved regions, $-35$ box and $-10$ box, influences of nucleotides in other positions are also not neglectable. For example, modifications of nucleotides around position $-19$ in spacing region may change promoter activity in a large scale. The results of this study might be helpful to our understanding of biophysical mechanism of gene transcription, and may also be helpful to the design of synthetic cell factory.
The Asymmetrical Wind of the Candidate Luminous Blue Variable MWC 314

We present the results of long‐term spectropolarimetric and spectroscopic monitoring of MWC 314, a candidate luminous blue variable star. We detect the first evidence of Hα variability in MWC 314 and find no apparent periodicity in this emission. The total R‐band polarization is observed to vary between 2.21% and 3.00% at a position angle consistently around ∼0°, indicating the presence of a time‐variable intrinsic polarization component, and hence an asymmetrical circumstellar envelope. We find suggestive evidence that MWC 314's intrinsic polarization exhibits a wavelength‐independent magnitude varying between 0.09% and 0.58% at a wavelength‐independent position angle covering all four quadrants of the Stokes Q‐U plane. Electron scattering off of density clumps in MWC 314's wind is considered as the probable mechanism responsible for these variations.
The structure of the Hospital Anxiety and Depression Scale in four cohorts of community-based, healthy older people: the HALCyon program

ABSTRACT Background: The Hospital Anxiety and Depression Scale (HADS) is widely used but evaluation of its psychometric properties has produced equivocal results. Little is known about its structure in non-clinical samples of older people. Methods: We used data from four cohorts in the HALCyon collaborative research program into healthy aging: the Caerphilly Prospective Study, the Hertfordshire Ageing Study, the Hertfordshire Cohort Study, and the Lothian Birth Cohort 1921. We used exploratory factor analysis and confirmatory factor analysis with multi-group comparisons to establish the structure of the HADS and test for factorial invariance between samples. Results: Exploratory factor analysis showed a bi-dimensional structure (anxiety and depression) of the scale in men and women in each cohort. We tested a hypothesized three-factor model but high correlations between two of the factors made a two-factor model more psychologically plausible. Multi-group confirmatory factor analysis revealed that the sizes of the respective item loadings on the two factors were effectively identical in men and women from the same cohort. There was more variation between cohorts, particularly those from different parts of the U.K. and in whom the HADS was administered differently. Differences in social-class distribution accounted for part of this variation. Conclusions: Scoring the HADS as two subscales of anxiety and depression is appropriate in non-clinical populations of older men and women. However, there were differences between cohorts in the way that individual items were linked with the constructs of anxiety and depression, perhaps due to differences in sociocultural factors and/or in the administration of the scale.
ADAMTS13 Predicts Renal and Cardiovascular Events in Type 2 Diabetic Patients and Response to Therapy

In patients with diabetes, impaired ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) proteolysis of highly thrombogenic von Willebrand factor (VWF) multimers may accelerate renal and cardiovascular complications. Restoring physiological VWF handling might contribute to ACE inhibitors’ (ACEi) reno- and cardioprotective effects. To assess how Pro618Ala ADAMTS13 variants and related proteolytic activity interact with ACEi therapy in predicting renal and cardiovascular complications, we genotyped 1,163 normoalbuminuric type 2 diabetic patients from BErgamo NEphrologic DIabetes Complications Trial (BENEDICT). Interaction between Pro618Ala and ACEi was significant in predicting both renal and combined renal and cardiovascular events. The risk for renal or combined events versus reference Ala carriers on ACEi progressively increased from Pro/Pro homozygotes on ACEi (hazard ratio 2.80 [95% CI 0.849–9.216] and 1.58 [0.737–3.379], respectively) to Pro/Pro homozygotes on non-ACEi (4.77 [1.484–15.357] and 1.99 [0.944–4.187]) to Ala carriers on non-ACEi (8.50 [2.416–29.962] and 4.00 [1.739–9.207]). In a substudy, serum ADAMTS13 activity was significantly lower in Ala carriers than in Pro/Pro homozygotes and in case subjects with renal, cardiovascular, or combined events than in diabetic control subjects without events. ADAMTS13 activity significantly and negatively correlated with all outcomes. In patients with diabetes, ADAMTS13 618Ala variant associated with less proteolytic activity, higher risk of chronic complications, and better response to ACEi therapy. Screening for Pro618Ala polymorphism may help identify patients with diabetes at highest risk who may benefit the most from early reno- and cardioprotective therapy.
Modelling and Verifying of Medical Diagnosis System Based on Context-Awareness Framework

Medical Diagnosis System is widely used in health care domain. Nowadays, advent of the era of Medical Diagnosis System means healthcare services at any time and at any places, which leads to advance studying and exploring of Medical Diagnosis Systems based on context-awareness framework. As a typical complex and widely used context aware system, reliable and complete designment of Medical Diagnosis System is espacially important. In this paper, we would analyze the modelling of a Medical Diagnosis System based on context-awareness theory in detail, proposes a new method of modelling, simulation and verification of such system, we would also present a typical illustration of context aware Medical Diagnosis System in this paper.
NFA reduction for regular expressions matching using FPGA

Many algorithms have been proposed to accelerate regular expression matching via mapping of a nondeterministic finite automaton into a circuit implemented in an FPGA. These algorithms exploit unique features of the FPGA to achieve high throughput. On the other hand the FPGA poses a limit on the number of regular expressions by its limited resources. In this paper, we investigate applicability of NFA reduction techniques - a formal aparatus to reduce the number of states and transitions in NFA prior to its mapping into FPGA. The paper presents several NFA reduction techniques, each with a different reduction power and time complexity. The evaluation utilizes regular expressions from Snort and L7 decoder. The best NFA reduction algorithms achieve more than 66% reduction in the number of states for a Snort ftp module. Such a reduction translates directly into 66% LUT-FF pairs saving in the FPGA.
A Study of Musical Instrument Classification Using Gaussian Mixture Models and Support Vector Machines

The Cambridge Research Laboratory was founded in 1987 to advance the state of the art in both core computing and human-computer interaction, and to use the knowledge so gained to support the Company's corporate objectives. We believe this is best accomplished through interconnected pursuits in technology creation, advanced systems engineering, and business development. We are multimedia data. We recognize and embrace a technology creation model which is characterized by three major phases: Freedom: The lifeblood of the Laboratory comes from the observations and imaginations of our research staff. It is here that challenging research problems are uncovered (through discussions with customers, through interactions with others in the Corporation, through other professional interactions, through reading, and the like) or that new ideas are born. For any such problem or idea, this phase culminates in the nucleation of a project team around a well-articulated central research question and the outlining of a research plan. Focus: Once a team is formed, we aggressively pursue the creation of new technology based on the plan. This may involve direct collaboration with other technical professionals inside and outside the Corporation. This phase culminates in the demonstrable creation of new technology which may take any of a number of forms—a journal article, a technical talk, a working prototype, a patent application, or some combination of these. The research team is typically augmented with other resident professionals—engineering and business development—who work as integral members of the core team to prepare preliminary plans for how best to leverage this new knowledge, either through internal transfer of technology or through other means. Follow-through: We actively pursue taking the best technologies to the marketplace. For those opportunities which are not immediately transferred internally and where the team has identified a significant opportunity, the business development and engineering staff will lead early-stage commercial development, often in conjunction with members of the research staff. While the value to the Corporation of taking these new ideas to the market is clear, it also has a significant positive impact on our future research work by providing the means to understand intimately the problems and opportunities in the market and to more fully exercise our ideas and concepts in real-world settings. Throughout this process, communicating our understanding is a critical part of what we do, and participating in the larger technical community—through the publication of refereed journal articles and the presentation of our ideas at conferences—is …
Alcohol consumption and heavy drinking: a survey in three Italian villages.

AIMS We investigated drinking habits, and heavy and problem drinking prevalence in a sample of individuals attending the consulting rooms of local General Practitioners in three Italian villages. METHODS The samples were selected to be representative of the entire population of the three villages. Information on alcohol-drinking patterns was collected using a questionnaire that included a masked form of the CAGE rating scale. According to the frequency of alcohol intake, subjects were grouped in three categories: abstainers, occasional drinkers, and daily drinkers. In agreement with WHO guidelines, 40 g/day for males and 20 g/day for females were taken as cut-off for 'heavy drinking' and consumptions of > 80 g/day for males and 40 g/day for females were used to define 'problem drinking'. RESULTS A total of 2972 individuals were included in the survey (19% of the population). Of these, 44% were abstinent, 20% occasional drinkers, and 36% daily drinkers. Daily drinking was found to be more common in males than in females but heavy drinking was significantly higher in females compared with males (P > or = 0.0001). The problem drinkers were 12% of the entire population and the CAGE-positive subjects (> or = 2 positive answers) were 3.5%. CONCLUSIONS Our data indicate that alcohol drinking is widely diffused in the three communities. A large layer of the population drinks above the WHO-established cut-off. The incidence of heavy and problem drinking seems to have significant gender and regional differences that are important to consider when planning effective prevention programmes.
Accessibility of Cities in the Digital Economy

This paper introduces a new measure to approach the accessibility of places in the frame of the digital economy. Information and Communication Technologies (ICTs) and the Internet are not equally spread around places and this heterogeneity affects spatial configuration. Despite the wide societal changes due to ICTs and the extensive interest in accessibility studies, these two themes have not yet come together in order to study the digital accessibility (DA) of places. Adopting an infrastructural perspective and a potential accessibility framework, a DA measure – embedding different types of impedance distance functions – is calculated for cities in Europe. Spatial Interaction Model and Complex Network Analysis are employed to calibrate and validate the DA results. The outcome of this approach is a new urban hierarchy which reveals a core-periphery pattern in Europe owing to digital accessibility.
SATIRE: A new incremental satisfiability engine

We introduce SATIRE, a new satisfiability solver that is particularly suited to verification and optimization problems in electronic design automation. SATIRE builds on the most recent advances in satisfiability research, and includes two new features to achieve even higher performance: a facility for incrementally solving sets of related problems, and the ability to handle non-CNF constraints. We provide experimental evidence showing the effectiveness of these additions to classical satisfiability solvers.
Large Shareholders and Corporate Control

In a corporation with many small owners, it may not pay any one of them to monitor the performance of the management. We explore a model in which the presence of a large minority shareholder provides a partial solution to this free-rider problem. The model sheds light on the following questions: Under what circumstances will we observe a tender offer as opposed to a proxy fight or an internal management shake-up? How strong are the forces pushing toward increasing concentration of ownership of a diffusely held firm? Why do corporate and personal investors commonly hold stock in the same firm, despite their disparate tax preferences?
Denying Psychological Properties of Girls and Prostitutes

This study examines the negative stereotypes of the category of women and their subcategories through the language of insults. Participants produced a list of epithets induced by the same hypothetical scenario in which the protagonist was presented either as a “prostitute” or as a “girl” (i.e., nonprostitute). Findings showed that the prostitute was addressed with taboo-related insults exaggerating sexual behavior, whereas the girl was mainly given warnings and intellectual insults. The implications of these results are discussed in relation to the underlying processes.
On the Spectral Density of the Wavelet Coefficients of Long‐Memory Time Series with Application to the Log‐Regression Estimation of the Memory Parameter

Abstract. In recent years, methods to estimate the memory parameter using wavelet analysis have gained popularity in many areas of science. Despite its widespread use, a rigorous semi‐parametric asymptotic theory, comparable with the one developed for Fourier methods, is still lacking. In this article, we adapt to the wavelet setting, the classical semi‐parametric framework introduced by Robinson and his co‐authors for estimating the memory parameter of a (possibly) non‐stationary process. Our results apply to a class of wavelets with bounded supports, which include but are not limited to Daubechies wavelets. We derive an explicit expression of the spectral density of the wavelet coefficients and show that it can be approximated, at large scales, by the spectral density of the continuous‐time wavelet coefficients of fractional Brownian motion. We derive an explicit bound for the difference between the spectral densities. As an application, we obtain minimax upper bounds for the log‐scale regression estimator of the memory parameter for a Gaussian process and we derive an explicit expression of its asymptotic variance.
Regulation of Rat Cortex Function by D1 Dopamine Receptors in the Striatum

Interactions between the basal ganglia and the cerebral cortex are critical for normal goal-directed behavior. In the present study, we used immediate-early genes (c-fos, zif 268) as functional markers to investigated how basal ganglia output altered by stimulation/blockade of D1 dopamine receptors in the striatum affects cortical function. Systemic administration of the mixed D1/D2 receptor agonist apomorphine (3 mg/kg) increased immediate-early gene expression in the striatum and throughout most of the cortex. Unilateral intrastriatal infusion of the selective D1 receptor antagonist SCH-23390 (0.5–10 μg) blocked this response bilaterally in striatum and cortex in a dose-dependent manner. Even apparently regionally restricted blockade of striatal D1 receptors attenuated gene expression throughout striatum and cortex in both hemispheres. Intrastriatal administration of the D1 antagonist inhibited apomorphine-induced sniffing/whisking, whereas other motor behaviors were unaffected. To determine whether such changes in cortical gene expression could reflect altered cortical function, we examined the effects of blocking striatal D1 receptors on whisker stimulation-evoked immediate-early gene expression in the sensorimotor cortex. Apomorphine increased sensory stimulation-evoked gene expression in the barrel cortex, and intrastriatal infusion of SCH-23390 attenuated this effect. These results suggest that stimulation of D1 dopamine receptors in the striatum exerts a widespread facilitatory effect on cortical function.
Influence of socioeconomic factors on hospital readmissions for heart failure and acute myocardial infarction in patients 65 years and older: evidence from a systematic review

Purpose Cardiovascular diseases are the leading cause of death and disability worldwide. Among these diseases, heart failure (HF) and acute myocardial infarction (AMI) are the most common causes of hospitalization. Therefore, readmission for HF and AMI is receiving increasing attention. Several socioeconomic factors could affect readmissions in this target group, and thus, a systematic review was conducted to identify the effect of socioeconomic factors on the risk for readmission in people aged 65 years and older with HF or AMI. Methods The search was carried out by querying an electronic database and hand searching. Studies with an association between the risk for readmission and at least one socioeconomic factor in patients aged 65 years or older who are affected by HF or AMI were included. A quality assessment was conducted independently by two reviewers. The agreement was quantified by Cohen’s Kappa statistic. The outcomes of studies were categorized in the short-term and the long-term, according to the follow-up period of readmission. A positive association was reported if an increase in the risk for readmission among disadvantaged patients was found. A cumulative effect of socioeconomic factors was computed by considering the association for each study and the number of available studies. Results A total of eleven articles were included in the review. They were mainly published in the United States. All the articles analyzed patients who were hospitalized for HF, and four of them also analyzed patients with AMI. Seven studies (63.6%) were found for the short-term outcome, and four studies (36.4%) were found for the long-term outcome. For the short-term outcome, race/ethnicity and marital status showed a positive cumulative effect on the risk for readmission. Regarding the educational level of a patient, no effect was found. Conclusion Among the socioeconomic factors, mainly race/ethnicity and marital status affect the risk for readmission in elderly people with HF or AMI. Multidisciplinary hospital-based quality initiatives, disease management, and care transition programs are a priority for health care systems to achieve better coordination.
EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations

Epithelial membrane protein 3 (EMP3) is a trans-membrane signaling molecule with important roles in the regulation of apoptosis, differentiation and invasion of cancer cells, but the detailed is largely still unknown. We analyzed the mRNA levels and methylation statuses of EMP3 in 63 primary breast carcinomas and assessed their correlations with clinicopathologic variables. The expression of EMP3 mRNA in primary breast carcinomas was significantly higher than the expression of 20 normal breast tissues (p<10-7). EMP3 overexpression in breast carcinomas was significantly related to histological grade III (p=3.9×10-7), lymph node metastasis (p=0.003), and strong Her-2 expression (p=3.3×10-6). Hypermethylation frequencies of EMP3 were detected in 36.5% of breast carcinomas by methylation-specific polymerase chain reaction. However, no significant correlations were found between methylation status of EMP3 and mRNA expression levels as well as other clinical parameters. In conclusion, EMP3 may be a novel marker of tumor aggressiveness. Overexpression of EMP3 in primary breast carcinoma is not associated with DNA methylation.
Long-term outcomes of limbal relaxing incisions during cataract surgery: aberrometric analysis

Purpose To compare the final changes in corneal wavefront aberration by limbal relaxing incisions (LRIs) after cataract surgery. Methods This prospective cumulative interventional nonrandomized case study included cataract and astigmatic patients undergoing LRIs and phaco with intraocular lens implantation. LRIs were planned using Donnenfeld nomogram. The root mean square of corneal wave aberration for total Z(n,i)(1≤n≤8), astigmatism Z(2,±1), coma Z(3–5–7,±1), trefoil Z(3–5–7,±2), spherical Z(4–6–8,0), and higher-order aberration (HOA) Z(3≤n≤8) was examined before and 3 years after surgery (optical path difference-Scan II [OPD-Scan II)]. Uncorrected distance visual acuity and best-corrected distance visual acuity (CDVA) for distance, keratometric cylinder, and variations in average corneal power were also analyzed. Results Sixty-four eyes of 48 patients were included in the study. Age ranged from 42 to 92 years (70.6±8.4 years). After LRIs, uncorrected distance visual acuity and best-corrected distance visual acuity improved statistically (P<0.01). The keratometric cylinder value decreased by 40.1%, but analysis of KP90 and KP135 polar values did not show any decrease that could be statistically confirmed (P=0.22 and P=0.24). No significant changes were detected in root mean square of total (P=0.61) and HOAs (P=0.13) aberrations. LRIs did not induce alteration in central corneal power confirming a 1:1 coupling ratio. Conclusion LRIs determined a nonsignificant alteration of corneal HOA. Therefore, LRIs can be still considered a qualitatively viable mean in those cases where toric intraocular lenses are contraindicated or not available. Yet, the authors raise the question of nonpersonalized nomograms, as in the present study, LRIs did not reach the preset target cylinder.
Cotangent Bundles with General Natural Kahler Structures

We study the conditions under which an almost Hermitian structure $(G,J)$ of general natural lift type on the cotangent bundle $T^*M$ of a Riemannian manifold $(M,g)$ is K\" ahlerian. First, we obtain the algebraic conditions under which the manifold $(T^*M,G,J)$ is almost Hermitian. Next we get the integrability conditions for the almost complex structure $J$, then the conditions under which the associated 2-form is closed. The manifold $(T^*M,G,J)$ is K\" ahlerian iff it is almost Kahlerian and the almost complex structure $J$ is integrable. It follows that the family of Kahlerian structures of above type on $T^*M$ depends on three essential parameters (one is a certain proportionality factor, the other two are parameters involved in the definition of $J$).