Miracle-dz/UniFAR-FTUs huggingface dataset:
Resting-State Networks and the Functional Connectome of the Human Brain in Agenesis of the Corpus Callosum

The corpus callosum is the largest white matter fiber bundle connecting the two cerebral hemispheres. In this work, we investigate the effect of callosal dysgenesis on functional magnetic resonance imaging (fMRI) resting-state networks and the functional connectome. Since alternate commissural routes between the cerebral hemispheres exist, we hypothesize that bilateral cortical networks can still be maintained in partial or even complete agenesis of the corpus callosum (AgCC). However, since these commissural routes are frequently indirect, requiring polysynaptic pathways, we hypothesize that quantitative measurements of interhemispheric functional connectivity in bilateral networks will be reduced in AgCC compared with matched controls, especially in the most highly interconnected cortical regions that are the hubs of the connectome. Seventeen resting-state networks were extracted from fMRI of 11 subjects with partial or complete AgCC and 11 matched controls. The results show that the qualitative organization of resting-state networks is very similar between controls and AgCC. However, interhemispheric functional connectivity of precuneus, posterior cingulate cortex, and insular-opercular regions was significantly reduced in AgCC. The preserved network organization was confirmed with a connectomic analysis of the resting-state fMRI data, showing five functional modules that are largely consistent across the control and AgCC groups. Hence, the reduction or even complete absence of callosal connectivity does not affect the qualitative organization of bilateral resting-state networks or the modular organization of the functional connectome, although quantitatively reduced functional connectivity can be demonstrated by measurements within bilateral cortical hubs, supporting the hypothesis that indirect polysynaptic pathways are utilized to preserve interhemispheric temporal synchrony.
Analysis/synthesis comparison

We compared six sound analysis/synthesis systems used for computer music. Each system analysed the same collection of twenty-seven varied input sounds, and output the results in Sound Description Interchange Format (SDIF). We describe each system individually then compare the systems in terms of availability, the sound model(s) they use, interpolation models, noise modelling, the mutability of various sound models, the parameters that must be set to perform analysis, and characteristic artefacts. Although we have not directly compared the analysis results among the different systems, our work has made such a comparison possible.
Gender and Prosocial Values During Adolescence: A Research Note

To date, relatively little is known about the prosocial values of adolescents. Research has shown that females attach more importance to certain prosocial values than males do in late adolescence but has not considered whether this gender difference is evident across stages of adolescence and whether it varies by race. We examine values that focus on doing things for others, using data from a nationwide survey of 12- to 17-year-olds. We find that girls place more importance on these prosocial values than boys at younger ages. However, we also find important patterns in this gender difference across racial groups as well as across age. White boys appear to attach less importance to prosocial values than other race and gender groups. Furthermore, the gender gap in prosocial values is larger at older ages, with older adolescent boys placing less importance on prosocial values than younger ones.
Epidemiology of Shoulder Dislocations in High School and Collegiate Athletics in the United States: 2004/2005 Through 2013/2014

Background: Shoulder dislocations occur frequently in athletes across a variety of sports. This study provides an updated descriptive epidemiological analysis of shoulder dislocations among high school and college athletes and compares injury rates and patterns across these age groups. Hypothesis: There would be no difference in injury rates/patterns between high school and college athletes. Study Design: Descriptive epidemiology study. Level of Evidence: Level 3. Methods: Shoulder dislocation data from the High School Reporting Information Online (RIO) and the National Collegiate Athletic Association (NCAA) Injury Surveillance Program (ISP) databases were analyzed from the 2004/2005 through 2013/2014 (NCAA) or 2005/2006 through 2013/2014 (RIO) academic years in 11 different sports. Rate ratios (RRs) and injury proportion ratios (IPRs) were calculated to make comparisons between age groups. Results: During the study period, 598 shoulder dislocations were reported during 29,249,482 athlete-exposures (AEs) among high school athletes, for an overall shoulder dislocation rate of 2.04 per 100,000 AEs; 352 shoulder dislocations were reported during 13,629,533 AEs among college athletes, for an overall injury rate of 2.58 per 100,000 AEs. College athletes had a higher rate of shoulder dislocation than high school athletes (RR, 1.26; 95% CI, 1.11-1.44). However, the injury rate in football was lower in collegiate than high school athletes (RR, 0.52; 95% CI, 0.43-0.62). Surgery was performed to correct 28.0% of high school and 29.6% of college shoulder dislocations. Shoulder dislocations resulted in longer return-to-play times than other shoulder injuries. Conclusion: Overall, shoulder dislocation rates were higher among collegiate than high school athletes. This may be due to greater contact forces involved in sports at higher levels of play, although the increased rate in high school football warrants additional research. Clinical Relevance: Higher shoulder dislocation rates within collegiate athletics are likely due to the higher level of intensity at this level of play, with stronger and faster athletes resulting in more forceful collisions.
Excluded from school: getting a second chance at a ‘meaningful’ education

In this paper, we draw upon the experiences of a group of young people who have been excluded from mainstream schools in two Australian states to provide an account of the ways in which they have found their way to education in educational sites that are variously referred to as ‘flexible learning centres', ‘second chance schools' and ‘alternative schools'. Whilst often clashing with school authorities in their original schools, these young people described how, when given the opportunity, they were able to engage in more meaningful learning in environments that recognised and accommodated their personal circumstances, and avoided authoritarian rule. A question we address is: What kinds of educational experiences facilitate ‘meaningful learning’ for these students?
Sense of community

This article revisits the theory of sense of community originally developed in 1976 and subsequently presented by McMillan and Chavis (1986). Chavis, Hogge, McMillan, and Wandersman (1986) demonstrated its empirical strength as a theory and developed the Sense of Community Questionnaire. This was essential work in getting the theory used. As reflected in the contents of this special issue, the theory has since stimulated considerable empirical research. © 1996 John Wiley & Sons, Inc.
Exotic Galilean Symmetry and Non-Commutative Mechanics ?

Some aspects of the "exotic" particle, associated with the two-parameter central extension of the planar Galilei group are reviewed. A fundamental property is that it has non-commuting position coordinates. Other and generalized non-commutative models are also discussed. Minimal as well as anomalous coupling to an external electromagnetic field is presented. Supersymmetric extension is also considered. Exotic Galilean symmetry is also found in Moyal field theory. Similar equations arise for a semiclassical Bloch electron, used to explain the anomalous/spin/optical Hall effects.
Physiological effects of resistant starches on fecal bulk, short chain fatty acids, blood lipids and glycemic index.

OBJECTIVE To assess the effects on fecal bulking, fecal short chain fatty acid (SCFA) production, blood lipids and glycemic indices of two different forms of resistant starch (RS2 and RS3) from a high-amylose cornstarch. METHODS Twenty-four healthy subjects (12 men; 12 women) consumed four supplements taken for 2 weeks in random order separated by 2-week washout periods. The supplements were a low-fiber (control) and supplements providing an additional 30 g dietary fiber as wheat bran (high-fiber control) or the equivalent amount of resistant starch analyzed gravimetrically as dietary fiber from RS2 or RS3. Four-day fecal collections and 12-hour breath gas collections were obtained at the end of each period. Fasting blood was taken at the beginning and end of each period. Glycemic indices of supplements were also assessed. RESULTS The wheat bran supplement increased fecal bulk 96+/-14 g/day compared with the low-fiber control (p<0.001) with the mean for both resistant starches also being greater (22+/-8 g/day) than the low-fiber control (p=0.013). On the resistant starch phases, the mean fecal butyrate:SCFA ratio, which has been suggested to have positive implications for colonic health, was significantly above the low-fiber control by 31+/-14% (p=0.035). Resistant starches did not alter serum lipids, urea or breath H2 or CH4. No significant differences in glycemic index were seen between the RS and control supplements. CONCLUSION The potential physiological benefits of the resistant starches studied appear to relate to colonic health in terms of effects on fecal bulk and SCFA metabolism.
Dopamine Signaling Leads to Loss of Polycomb Repression and Aberrant Gene Activation in Experimental Parkinsonism

Polycomb group (PcG) proteins bind to and repress genes in embryonic stem cells through lineage commitment to the terminal differentiated state. PcG repressed genes are commonly characterized by the presence of the epigenetic histone mark H3K27me3, catalyzed by the Polycomb repressive complex 2. Here, we present in vivo evidence for a previously unrecognized plasticity of PcG-repressed genes in terminally differentiated brain neurons of parkisonian mice. We show that acute administration of the dopamine precursor, L-DOPA, induces a remarkable increase in H3K27me3S28 phosphorylation. The induction of the H3K27me3S28p histone mark specifically occurs in medium spiny neurons expressing dopamine D1 receptors and is dependent on Msk1 kinase activity and DARPP-32-mediated inhibition of protein phosphatase-1. Chromatin immunoprecipitation (ChIP) experiments showed that increased H3K27me3S28p was accompanied by reduced PcG binding to regulatory regions of genes. An analysis of the genome wide distribution of L-DOPA-induced H3K27me3S28 phosphorylation by ChIP sequencing (ChIP-seq) in combination with expression analysis by RNA-sequencing (RNA-seq) showed that the induction of H3K27me3S28p correlated with increased expression of a subset of PcG repressed genes. We found that induction of H3K27me3S28p persisted during chronic L-DOPA administration to parkisonian mice and correlated with aberrant gene expression. We propose that dopaminergic transmission can activate PcG repressed genes in the adult brain and thereby contribute to long-term maladaptive responses including the motor complications, or dyskinesia, caused by prolonged administration of L-DOPA in Parkinson's disease.
Checking the Fact-Checkers in 2008: Predicting Political Ad Scrutiny and Assessing Consistency

Which types of political ads are most likely to draw criticism from fact-checkers? Are fact-checkers consistent in their evaluations of political ads? Examining general election television ads from the 2008 U.S. presidential race, and based upon the evaluations of FactCheck.org, PolitiFact.com, and the Washington Post's Fact Checker, this study demonstrates it was the attack ads from candidates that were most likely to draw scrutiny from the fact-checkers. Most importantly, a high level of agreement between the fact-checkers indicates their success at selecting political claims that can be consistently evaluated. While political advertisers are increasingly using evidence to support their claims, what may be more critical in drawing evaluations from fact-checkers is the verifiability of a claim. The implications of consistent fact-checking on the public, political actors, journalism and democracy are discussed. With the revelation that fact-checking can be consistently practiced, localized efforts at fact-checking need encouragement, particularly as political TV ads increasingly drown out other potential sources of information for the public and increasingly are used in downballot races, local initiatives, referendums and judicial races.
The Role of Retrotransposons in Gene Family Expansions in the Human and Mouse Genomes

Abstract Retrotransposons comprise a large portion of mammalian genomes. They contribute to structural changes and more importantly to gene regulation. The expansion and diversification of gene families have been implicated as sources of evolutionary novelties. Given the roles retrotransposons play in genomes, their contribution to the evolution of gene families warrants further exploration. In this study, we found a significant association between two major retrotransposon classes, LINEs and LTRs, and lineage-specific gene family expansions in both the human and mouse genomes. The distribution and diversity differ between LINEs and LTRs, suggesting that each has a distinct involvement in gene family expansion. LTRs are associated with open chromatin sites surrounding the gene families, supporting their involvement in gene regulation, whereas LINEs may play a structural role promoting gene duplication. Our findings also suggest that gene family expansions, especially in the mouse genome, undergo two phases. The first phase is characterized by elevated deposition of LTRs and their utilization in reshaping gene regulatory networks. The second phase is characterized by rapid gene family expansion due to continuous accumulation of LINEs and it appears that, in some instances at least, this could become a runaway process. We provide an example in which this has happened and we present a simulation supporting the possibility of the runaway process. Altogether we provide evidence of the contribution of retrotransposons to the expansion and evolution of gene families. Our findings emphasize the putative importance of these elements in diversification and adaptation in the human and mouse lineages.
Suicide and the Internalization of Culture: Three Questions

Despite much writing and discussion on suicide that gives credence to the importance of a multidimensional perspective, the current view of suicide continues to be strongly person-centered. Examining suicide from a cultural vantage point, three questions are suggested for investigation concerning (1) the internalization of the idea of suicide, (2) individual and collective vulnerability to this idea, and (3) the 'great origin myth' in suicidology. Although the act of killing oneself is ultimately that of an individual, it is argued here that it is less a solo venture than a product of the collectivity of ideas. A deeper understanding of suicide will be realized through theory incorporating the dialectic of person and culture.
Conditions For Self-Confidence Among Boys And Girls Achieving Highly in Chemistry

Both in academic chemistry programs and in career fields that demand knowledge in the area of chemistry, one finds that talented girls and women are generally underrepresented. They often have poorer grades, demonstrate lower levels of self-confidence, and report higher levels of anxiety. The exact causes of these gender differences have not yet been fully understood. The current work is based on the assumption that gender differences in chemistry-relevant variables can be identified as a consequence of gender-specific socialization processes already existent in introductory chemistry courses. In the present study, the self-confidence levels of male and female students was of particular interest. In fact, within a study of 379 eighth-grade boys and girls attending a college preparatory school, it could be shown that even at this early point in time when experiences with chemistry instruction had not yet ocurred, talented girls had significantly lower levels of self-confidence regarding chemistry compared to boys. Several explanatory approaches are examined, and pedagogic consequences are proposed.
Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo

The extracellular segment of the receptor-type type protein tyrosine phosphatase PTPmu, possesses an MAM domain, an immunoglobulin domain, and four fibronectin type-III repeats. It binds homophilically, i.e., PTPmu on the surface of one cell binds to PTPmu on an apposing cell, and the binding site lies within the immunoglobulin domain. The intracellular segment of PTPmu has two PTP domains and a juxtamembrane segment that is homologous to the conserved intracellular domain of the cadherins. In cadherins, this segment interacts with proteins termed catenins to mediate association with the actin cytoskeleton. In this article, we demonstrate that PTPmu associates with a complex containing cadherins, alpha- and beta-catenin in mink lung (MvLu) cells, and in rat heart, lung, and brain tissues. Greater than 80% of the cadherin in the cell is cleared from Triton X-100 lysates of MvLu cells after immunoprecipitation with antibodies to PTPmu; however, the complex is dissociated when lysates are prepared in more stringent, SDS-containing RIPA buffer. In vitro binding studies demonstrated that the intracellular segment of PTPmu binds directly to the intracellular domain of E-cadherin, but not to alpha- or beta-catenin. Consistent with their ability to interact in vivo, PTPmu, cadherins, and catenins all localized to points of cell-cell contact in MvLu cells, as assessed by immunocytochemical staining. After pervanadate treatment of MvLu cells, which inhibits cellular tyrosine phosphatase activity including PTPmu, the cadherins associated with PTPmu are now found in a tyrosine- phosphorylated form, indicating that the cadherins may be an endogenous substrate for PTPmu. These data suggest that PTPmu may be one of the enzymes that regulates the dynamic tyrosine phosphorylation, and thus function, of the cadherin/catenin complex in vivo.
An investigation of teachers' loneliness in the workplace in terms of human values they possess

The purpose of this study is to investigate teachers’ loneliness in the workplace in terms of human values they possess. The research is of the relational survey model. Teachers’ perception of human values forms the independent variables of the research model. The level of teachers’ loneliness in the workplace, on the other hand, constitutes the dependent variables of the research model. The study group of the present research consists of 472 primary education teachers working in the Konya Province of Turkey in 2009 who were selected using the random cluster sampling method. Of the teachers who constituted the sample, 242 were male and 230 were female. Schwartz’ Values Inventory was used to measure teachers’ preferences of human values and Loneliness in the Workplace Scale was used to measure their loneliness in the workplace. The results of the study indicate that there is a negative correlation between teachers’ preferences of human values and the emotional deprivation and social companionship dimensions of loneliness in the workplace. Likewise, teachers’ preferences of values account for variability in the emotional deprivation and social companionship dimensions of loneliness.
Actual, ideal, and expected relatedness with parents across and within cultures

Differences in actual, ideal, and expected relatedness with mothers and fathers were explored across two cultural groups (i.e., university students from the U.S. and Turkey) in Study 1, and across two socioeconomic status (SES) groups (i.e., high school students from the upper and lower SES in Turkey) in Study 2. In both studies associations of perceived relatedness with individualistic and collectivistic value orientations as well as with self-construal types were also explored. Results indicated cultural groups to be quite similar in actual relatedness, but to differ in expected and ideal relatedness, with Turks reporting more relatedness. In Turkey, lower SES adolescents reported more relatedness in ideal and actual conditions than upper SES adolescents, while they did not differ in expected relatedness. Results involving self-types and value orientations pointed to both cross-cultural similarities and within-cultural diversity in relatedness. Theoretical implications of the differential impact of culture, SES, self-construals, and value orientations on actual, ideal, and expected relatedness are discussed.
Writing in Young Deaf Children

The authors conducted an integrative review of the research literature on the writing development, writing instruction, and writing assessment of young deaf children ages 3 to 8 years (or preschool through third grade) published between 1990 and 2012. A total of 17 studies were identified that met inclusion criteria. The analysis examined research problems, theoretical frames, research methodologies, and major findings across the body of work. Findings of the review indicated that much of the research has focused on spelling, and when studies examined writing development, the analyses were limited to the word level. Assessment of writing has been largely ignored. Results also indicated that two primary conceptual frameworks have dominated the field across the 22-year span, with divergent implications for pedagogy and practice. The researchers call for longitudinal studies that examine deaf children’s use of English grammar and syntax within connected discourse.
From an Intrateam to an Interteam Perspective of Effectiveness: The Role of Interdependence and Boundary Activities

The emergence of team-based organizations requires shifting the focus from intrateam to interteam activities in order to understand organizational functioning. This article develops a model of interteam boundary activity and proposes that boundary activity is contingent on interteam goal and task interdependence. In addition, the authors propose that team heterogeneity, interteam power relations, organizational culture, and external environment moderate the relationships between interteam interdependence configuration and boundary activity. The preferred boundary activity further determines whether higher team performance fully translates into higher organizational performance. The article concludes by considering the research and practice challenges implied by the proposed model.
Are Chronic Exposure To Violence and Chronic Violent Behavior Closely Related Developmental Processes During Adolescence?

Five waves of longitudinal data from a sample of minority youth living in extreme poverty were used to examine the impact of chronic exposure to violence on chronic violent behavior. Given the rapid rate of developmental change during adolescence and the lack of multiyear studies of exposure to violence, semiparametric group-based modeling was used to identify trajectories of chronic exposure to violence (7% of youth), chronic violent victimization (9% of youth), chronic vicarious victimization (39% of youth), and chronic violent behavior (12% of youth). The multivariate findings revealed that (a) youth with chronic exposure to violence were 3,150% (or 31.5 times) more likely to engage in chronic violent behavior and (b) chronic vicarious victimization was a significant predictor of chronic violent behavior, after controlling for the effects of chronic violent victimization. The theoretical and policy implications of these findings as well as areas for future research are discussed.