Miracle-dz/UniFAR-FTUs huggingface dataset:
Multistep Model of Cervical Cancer: Participation of miRNAs and Coding Genes

Aberrant miRNA expression is well recognized as an important step in the development of cancer. Close to 70 microRNAs (miRNAs) have been implicated in cervical cancer up to now, nevertheless it is unknown if aberrant miRNA expression causes the onset of cervical cancer. One of the best ways to address this issue is through a multistep model of carcinogenesis. In the progression of cervical cancer there are three well-established steps to reach cancer that we used in the model proposed here. The first step of the model comprises the gene changes that occur in normal cells to be transformed into immortal cells (CIN 1), the second comprises immortal cell changes to tumorigenic cells (CIN 2), the third step includes cell changes to increase tumorigenic capacity (CIN 3), and the final step covers tumorigenic changes to carcinogenic cells. Altered miRNAs and their target genes are located in each one of the four steps of the multistep model of carcinogenesis. miRNA expression has shown discrepancies in different works; therefore, in this model we include miRNAs recording similar results in at least two studies. The present model is a useful insight into studying potential prognostic, diagnostic, and therapeutic miRNAs.
Effect of Enrichment of In Vitro Fertilization Medium with Cysteine on Fertilization and Embryo Development in Buffaloes

1 Faculty of Veterinary Medicine, Theriogenology Department, Aswan University, Egypt. 2 Faculty of Veterinary Medicine, Theriogenology Department, Mansoura University, Egypt. 3 Artificial Insemination and Embryo Transfer Department, Animal Reproduction Research Institute, Al Haram, Giza, Egypt. 4 Faculty of Veterinary Medicine, Department of Theriogenology, Veterinary Teaching Hospital, Mansoura University, Egypt. 5 Faculty of Science, Department of Biology, Taif University, Taif, Saudi Arabia.
Reliability analysis of moment redistribution in reinforced concrete beams

Design codes allow a limited amount of moment redistribution in continuous reinforced concrete beams and often make use of lower bound values in the procedure for estimating the moment redistribution factors. Here, based on the concept of demand and capacity rotation, and by means of Monte Carlo simulation, a probabilistic model is derived for the evaluation of moment redistribution factors. Results show that in all considered cases, the evaluated mean and nominal values of moment redistribution factor are greater than the values provided by the ACI code. On the other hand, the 5th percentile value of moment redistribution factor could be lower than those specified by the code. Although the reduction of strength limit state reliability index attributable to uncertainty in moment redistribution factors is not large, it is comparable to the reduction in reliability index resulting from increasing the ratio of live to dead load.
Mitochondrial Lysyl-tRNA Synthetase Independent Import of tRNA Lysine into Yeast Mitochondria

Aminoacyl tRNA synthetases play a central role in protein synthesis by charging tRNAs with amino acids. Yeast mitochondrial lysyl tRNA synthetase (Msk1), in addition to the aminoacylation of mitochondrial tRNA, also functions as a chaperone to facilitate the import of cytosolic lysyl tRNA. In this report, we show that human mitochondrial Kars (lysyl tRNA synthetase) can complement the growth defect associated with the loss of yeast Msk1 and can additionally facilitate the in vitro import of tRNA into mitochondria. Surprisingly, the import of lysyl tRNA can occur independent of Msk1 in vivo. This suggests that an alternative mechanism is present for the import of lysyl tRNA in yeast.
Internet Versus Mailed Questionnaires: A Randomized Comparison

Background The use of Internet-based questionnaires for collection of data to evaluate patient education and other interventions has increased in recent years. Many self-report instruments have been validated using paper-and-pencil versions, but we cannot assume that the psychometric properties of an Internet-based version will be identical. Objectives To look at similarities and differences between the Internet versions and the paper-and-pencil versions of 16 existing self-report instruments useful in evaluation of patient interventions. Methods Participants were recruited via the Internet and volunteered to participate (N=397), after which they were randomly assigned to fill out questionnaires online or via mailed paper-and-pencil versions. The self-report instruments measured were overall health, health distress, practice mental stress management, Health Assessment Questionnaire (HAQ) disability, illness intrusiveness, activity limitations, visual numeric for pain, visual numeric for shortness of breath, visual numeric for fatigue, self-efficacy for managing disease, aerobic exercise, stretching and strengthening exercise, visits to MD, hospitalizations, hospital days, and emergency room visits. Means, ranges, and confidence intervals are given for each instrument within each type of questionnaire. The results from the two questionnaires were compared using both parametric and non-parametric tests. Reliability tests were given for multi-item instruments. A separate sample (N=30) filled out identical questionnaires over the Internet within a few days and correlations were used to assess test-retest reliability. Results Out of 16 instruments, none showed significant differences when the appropriate tests were used. Construct reliability was similar within each type of questionnaire, and Internet test-retest reliability was high. Internet questionnaires required less follow-up to achieve a slightly (non-significant) higher completion rate compared to mailed questionnaires. Conclusions Among a convenience sample recruited via the Internet, results from those randomly assigned to Internet participation were at least as good as, if not better than, among those assigned mailed questionnaires, with less recruitment effort required. The instruments administered via the Internet appear to be reliable, and to be answered similarly to the way they are answered when they are administered via traditional mailed paper questionnaires.
Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes. Telomere attrition can lead to potentially maladaptive cellular changes, block cell division, and interfere with tissue replenishment. Recent advances in the understanding of human disease processes have clarified the roles of telomere biology, especially in diseases of human aging and in some aging-related processes. Greater overall telomere attrition predicts mortality and aging-related diseases in inherited telomere syndrome patients, and also in general human cohorts. However, genetically caused variations in telomere maintenance either raise or lower risks and progression of cancers, in a highly cancer type–specific fashion. Telomere maintenance is determined by genetic factors and is also cumulatively shaped by nongenetic influences throughout human life; both can interact. These and other recent findings highlight both causal and potentiating roles for telomere attrition in human diseases.
Conspicuous political brand interactions on social network sites

Acquiring “Likes” for a political party or candidate’s Facebook pages is important for political marketers. For consumers, these “Likes” are conspicuous, making their political affiliation visible to their network. This paper aims to examine the roles of the undesired social-self and visibility (conspicuous vs inconspicuous) in predicting consumers’ intention to “Like” political brands. The authors extend knowledge on the undesired social-self and transference of theory from general marketing to a political domain and provide practical advice for political marketers engaging social network sites. ,The authors gather data from two surveys run with Facebook using electorates in the run up to the UK 2015 and US 2016 elections (n = 1,205) on their intention to “Like” political brands under different visibility conditions. ,Data support the theorized relationship of the undesired social-self with social anxiety intention to “Like” when “Liking” is conspicuous. However, data also indicate that all users – irrespective of proximity to the undesired social-self – prefer to “Like” inconspicuously. ,The research is limited by the generalizability of the specific context and the use of self-report measures. ,Political marketers should reconsider promoting conspicuous consumption for that which is more inconspicuous. ,The authors provide the first examination of the undesired social-self in driving behaviour under different visibility conditions. Furthermore, the authors challenge the extension of existing knowledge of the self-concept within political marketing, based on the “norm” for consumers’ to avoid disclosing political views publically.
Unraveling the mysteries of sleep-disordered breathing in children.

The anesthesiologist clearly caused this patient’s vision loss by letting the mean arterial blood pressure drop below 60 mmHg for more than 5 min. This patient is now blind because the anesthesiologist let the patient’s hematocrit level decrease to less than 24% during the case. The person providing the patient’s anesthesia failed to avoid prolonged pressure on the eye, leading to the patient’s ischemic optic neuropathy and blindness.
Article Reference

Preoperative diastolic function predicts the onset of left ventricular dysfunction following aortic valve replacement in high-risk patients with aortic stenosis LICKER, Marc, et al. Abstract INTRODUCTION: Left ventricular (LV) dysfunction frequently occurs after cardiac surgery, requiring inotropic treatment and/or mechanical circulatory support. In this study, we aimed to identify clinical, surgical and echocardiographic factors that are associated with LV dysfunction during weaning from cardiopulmonary bypass (CPB) in high-risk patients undergoing valve replacement for aortic stenosis. METHODS: Perioperative data were prospectively collected in 108 surgical candidates with an expected operative mortality ≥ 9%. All anesthetic and surgical techniques were standardized. Reduced LV systolic function was defined by an ejection fraction
Reputation, Quality Observability, and the Choice of Quality Assurance Systems

Participants in a supply chain of agricultural value-added products face significant challenges. Many of the costly distinctive traits desired by consumers are difficult (if not impossible) to observe even after consumption. A complicating factor, addressed here, is that in some circumstances delivered quality can only be imperfectly learned and/or affected stochastically by producers. Hence, both symmetric and asymmetric informational imperfections may be present. In order for markets for these classes of goods to arise, firms touting the quality of the product need to be trusted. A repeated-purchases model is developed to explore the fundamental economic factors that lie behind the choice of different quality assurance systems and their associated degrees of stringency by firms. Differences in the quality discoverability of a sought-after attribute, attractiveness of a market, and the value placed in the future are among the factors contributing to the implementation of widely diverse systems across participants in different markets. Close attention is paid to the role of reputations in providing the incentives for firms to deliver high-quality goods in an environment of symmetrically imperfect information.
Intravitreal Bevacizumab Followed by Ranibizumab for Neovascular Age Related Macular Degeneration

Purpose: To compare the outcomes after switching from intravitreal bevacizumab (IVB) to intravitreal ranibizumab (IVR) in patients with neovascular age related macular degeneration (ARMD). Material and Methods: A retrospective review of patients with neovascular ARMD, who were switched from treatment with Pro Re Nata (PRN) IVB to PRN IVR, was conducted in a university clinic. IVB (1.25 mg/0.05 ml) and IVR (0.5 mg/0.05 ml) were used. Re- treatment criteria were defined based on an activity scoring (AS) system developed in our clinic. An AS was calculated for each lesion at each visit. AS results and the number of injections before and after switching treatment to IVR were compared. Results: 32 eyes of 31 patients with neovascular ARMD were included in the study. The mean follow-up period was 12.3±4.7 months. The mean duration of IVB treatment was 8.1±3.1 months followed by 4.2±1.6 months with IVR. At the beginning of the study the mean AS was 8.9, (Visual Acuity) VA : 0.99 logMAR, and Central Foveal Thickness (CFT): 312.7±81. 1µ. A month after the last IVB injection, AS became 5.1, VA: 0.69 logMAR, and CFT: 210.4±80. 4µ (p 0.05). Conclusions: This study shows that the improvement in AS, CFT, and VA, achieved with the PRN IVB treatment, seems to be main- tained after switching to IVR.
Tubular adenoma of the common bile duct with uptake in 18F-FDG PET: A case report

A 64-year-old man presented with epigastric discomfort and nausea. Laboratory analyses revealed increased levels of total and direct bilirubin, and increased levels of aminotransferases. Computed tomography revealed the presence of a mass in the distal common bile duct. Endoscopic retrograde cholangiopancreatography and intraductal ultrasonography revealed a 25 mm filling defect in the distal common bile duct, and biopsy of the lesion disclosed the presence of tubular adenoma. Using fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) revealed an increased accumulation of the tracer in the lesion, with a maximum standard uptake value (SUVmax) of 3.3. The patient received a pylorus-preserving pancreatoduodenectomy. The histopathological examination revealed a tubular adenoma with low-grade atypia. The patient remains alive 15 months following the surgery, with no evidence of recurrence of the adenoma. 18F-FDG PET has been successfully applied in clinical practice to detect a wide variety of tumor types, including lymphoma, lung, colon and bile duct cancer. In the present study, a case of bile duct adenoma with low-grade atypia was reported, revealing the uptake of 18F-FDG. 18F-FDG PET may be able to detect premalignant tumors of the bile duct, although whether 18F-FDG PET is able to differentially discriminate between diagnoses of adenoma and carcinoma of the bile duct remains to be fully elucidated, and the assessment of further case studies is required.
Electric otors and Drives in Torsional Vibration Analysis and Design

Two types of prime movers are continuously applied for rotating machinery: mechanical and electric drives. This tutorial focuses on electric drives, which are actually composed of separate components: electric motor, frequency converter (optional), and electric network including transformers. The main aim of this tutorial is to explain the phenomena of electric drives related to the torsional vibrations. All the components of an electric drive may affect torsional dynamics of the system. Naturally the main concern is torsional excitations. Another aspect is the electromechanical interaction in the air-gap of the motor that produces electromagnetic torsional stiffness and damping. These and other similar phenomena, related to the electric drives, have been observed on test fields and site conditions. The scope of the paper includes the most common induction, synchronous and permanent magnet motors. First, the various rotor structures of electric motors are discussed. Then, the effects of electromagnetic stiffness and damping on the torsional dynamics are introduced. Next, the main electric excitations are presented and their effect on drivetrain dimensioning is discussed. Various modelling and analysis methods are also presented for drive-trains with an electric motor. The previous sections focus on the motor without any frequency converter. The rest of the paper deals with the variable speed drives. First the main voltage source inverter, current source inverter and load commutated inverter drive types, their operational principles and application areas are introduced. Then the harmonic and inter-harmonic torsional excitations are Proceedings of the Forty-Second Turbomachinery Symposium October 1-3, 2013, Houston, Texas
Asthma and allergy as risk factors for suicidal behavior among young adults

ABSTRACT An association between allergic disease, depression and suicidality has been reported. Objective: To explore the relationships between suicidality and asthma, allergy, internet addiction, stress, sleep quality, pain/discomfort, and depression, among emerging adults. Participants: 929 college students completed an online survey between October 2015 and April 2017. Methods: A cross-sectional study using multivariate analysis techniques was implemented. Results: Using structural equation modeling, we found that allergies and stress were directly related to pain/discomfort; pain/discomfort was associated to poor sleep, depression, and suicidality. Sleep quality was also affected by stress; while sleep, stress, pain/discomfort, and internet addiction were directly related to depression (all p < .05). Ultimately, four factors impacted suicidality: stress, pain/discomfort, depression, and, indirectly, sleep quality (all p < .05). Although allergy had some effects, these did not reach statistical significance (p < .09). Conclusion: Findings suggest that allergy might impact suicidality indirectly through increased pain/discomfort, poor sleep, and depression.
Effect of heat conservation during and after major abdominal surgery on muscle protein breakdown in elderly patients.

Changes in mean body temperature and muscle protein metabolism were studied in elderly patients undergoing large bowel surgery. Two groups were studied: in one, efforts were made to maintain the patients normothermic during and after surgery by warming the fresh gases, the i.v. fluids, by placing warmed cotton padding around the exposed parts of the body and by covering the patients with a metallized plastic sheet in the recovery period. The other group received routine management. Otherwise the anaesthetic technique was comparable. The excretion of the amino acid 3-methylhistidine (3-MeH), an indicator of muscle protein breakdown, and urea nitrogen loss were measured in the urine collected the day before, and on the 2nd and 4th postoperative days. Prevention of heat loss during and after surgery caused a significant decrease in muscle protein degradation and nitrogen loss.
Nursing Sensitive Outcomes After Severe Traumatic Brain Injury: A Nationwide Study

ABSTRACT Background: Complications such as infections and conditions after immobilization are frequent after severe traumatic brain injury (TBI) due to compromised bodily functions. Traditionally, bodily functions are core elements in nursing, and therefore nurses in the rehabilitation departments are pivotal in the prevention of complications. Hence, the frequency of complications is an indicator of nursing care quality, which can be included in nursing-sensitive outcome indicators. To do so, it is necessary to know the frequency of the selected complications. Objective: The aim of this study was to quantify complications during the first year after severe TBI. Participants: This study included patients 15 years or older who received subacute neurorehabilitation after severe TBI from 2011 to 2015 (N = 469). Design: This is a register-based follow-up study using data from the Danish Head Trauma Database, a national clinical quality database aimed at monitoring and improving the quality of rehabilitation for patients with severe TBI. Main Measures: The following complications were assessed: urinary tract infection, pneumonia, pressure ulcers, joint contractures, and deep venous thrombosis. The prevalence of each complication was calculated at admission, discharge, and 1 year postinjury and for the period from admission and during subacute rehabilitation. In addition, the frequency of complications that certainly developed during subacute rehabilitation was calculated. Complications were compared between age-specific subgroups using multivariable binominal regression analyses. Results: Urinary tract infections (53%) and pneumonia (32%) were the most common complications in the period from admission and during subacute rehabilitation. Pressure ulcers (18%), joint contractures (18%), and deep venous thrombosis (4%) were less frequent. At discharge and 1 year postinjury, the prevalence was less than 4% for all complications, except for joint contractures (16% and 13% at discharge and 1 year postinjury, respectively). Conclusion: The prevalence of complications was high. The findings are important for future quality improvement of the rehabilitation trajectory and for further studies that explore the high frequency of complications.
Formation of the thermal infrared continuum in solar flares

Observations of the Sun with the Atacama Large Millimeter Array have now started, and the thermal infrared will regularly be accessible from the NSF's Daniel K. Inouye Solar Telescope. Motivated by the prospect of these new data, and by recent flare observations in the mid infrared, we set out here to model and understand the source of the infrared continuum in flares, and to explore its diagnostic capability for the physical conditions in the flare atmosphere. We use the 1D radiation hydrodynamics code RADYN to calculate mid-infrared continuum emission from model atmospheres undergoing sudden deposition of energy by non-thermal electrons. We identify and characterise the main continuum thermal emission processes relevant to flare intensity enhancement in the mid- to far-infrared (2-200 $\mu$m) spectral range as free-free emission on neutrals and ions. We find that the infrared intensity evolution tracks the energy input to within a second, albeit with a lingering intensity enhancement, and provides a very direct indication of the evolution of the atmospheric ionization. The prediction of highly impulsive emission means that, on these timescales, the atmospheric hydrodynamics need not be considered in analysing the mid-IR signatures.
Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein.

BACKGROUND It has been suggested that a protein hydrolysate, as opposed to its intact protein, is more easily digested and absorbed from the gut, which results in greater plasma amino acid availability and a greater muscle protein synthetic response. OBJECTIVE We aimed to compare dietary protein digestion and absorption kinetics and the subsequent muscle protein synthetic response to the ingestion of a single bolus of protein hydrolysate compared with its intact protein in vivo in humans. DESIGN Ten elderly men (mean +/- SEM age: 64 +/- 1 y) were randomly assigned to a crossover experiment that involved 2 treatments in which the subjects consumed a 35-g bolus of specifically produced L-[1-(13)C]phenylalanine-labeled intact casein (CAS) or hydrolyzed casein (CASH). Blood and muscle-tissue samples were collected to assess the appearance rate of dietary protein-derived phenylalanine in the circulation and subsequent muscle protein fractional synthetic rate over a 6-h postprandial period. RESULTS The mean (+/-SEM) exogenous phenylalanine appearance rate was 27 +/- 6% higher after ingestion of CASH than after ingestion of CAS (P < 0.001). Splanchnic extraction was significantly lower in CASH compared with CAS treatment (P < 0.01). Plasma amino acid concentrations increased to a greater extent (25-50%) after the ingestion of CASH than after the ingestion of CAS (P < 0.01). Muscle protein synthesis rates averaged 0.054 +/- 0.004% and 0.068 +/- 0.006%/h in the CAS and CASH treatments, respectively (P = 0.10). CONCLUSIONS Ingestion of a protein hydrolysate, as opposed to its intact protein, accelerates protein digestion and absorption from the gut, augments postprandial amino acid availability, and tends to increase the incorporation rate of dietary amino acids into skeletal muscle protein.