Miracle-dz/UniFAR-FTUs huggingface dataset:
APOB gene signal peptide deletion polymorphism is not associated with infertility in Indian men.

Apolipoprotein B (APOB) plays a key role in lipoprotein metabolism and plasma lipid transport. It has been shown that about two-thirds of male mice heterozygous for ApoB were infertile. Moreover, a 3-codon deletion polymorphism (rs11279109) in the signal peptide region of the APOB gene has been shown to be a risk factor for infertility in Slovenian men, but its association with infertility in Indian men has not been evaluated to date. Hence, in the present study, we have genotyped this polymorphism in 545 Indian men, including 294 infertile and 251 fertile men. Our results show that the distribution of this deletion polymorphism was consistent with the Hardy-Weinberg equilibrium in both infertile and fertile men. No statistically significant difference was observed in the distribution of the APOB signal peptide deletion polymorphism between infertile and fertile men (chi(2) = 0.156, P = . 925 for genotypes; chi(2) = 0.015, P = . 903 for alleles). Moreover, no significant difference was observed when infertile and fertile men were categorized on the basis of presence (D/D and D/W genotypes) or absence (W/W genotypes) of deletion (odds ratio, 0.955; 95% confidence interval, 0.644-01.418; P = .820). Our study concludes that the APOB gene deletion polymorphism is not a risk factor for the development of infertility in Indian men.
The effects of knowledge on security technology adoption: Results from a quasi-experiment

We conducted a quasi-experiment through an online survey to investigate the effects of information security knowledge on users' adoption of security technologies. We found that knowledge can affect adoption decision in multiple ways. On the one hand, knowledge tends to increase a user's self-efficacy in using the technology, which in turn increases the perceived usefulness of the technology, consistent with the Technology Acceptance Model (TAM). On the other hand, users who are knowledgeable about information security are less likely to come up with a poor adoption decision. These findings suggest that firms may need to use different strategies when trying to market security technologies to users with different knowledge levels. Furthermore, a firm that produces useful security technologies may wish to spend resources to educate users in order to increase their self-efficacy and their perceived usefulness of the technologies.
Differential effects of strain, circadian cycle, and stimulation pattern on LTP and concurrent LTD in the dentate gyrus of freely moving rats

Because long‐term potentiation (LTP) and long‐term depression (LTD) are thought to be involved in learning and memory, it is important to delineate factors that modulate their induction and persistence, especially as studied in freely moving animals. Here, we investigated the effects of rat strain, circadian cycle, and high‐frequency stimulation (HFS) pattern on LTP and concurrently induced LTD in the dentate gyrus (DG). Comparison of two commonly used rat strains revealed that medial perforant path field EPSP‐population spike (E‐S) coupling and LTP were greater in Long‐Evans than Sprague‐Dawley rats. Circadian cycle experiments conducted in Long‐Evans rats revealed greater E‐S coupling and enhanced LTP during the dark phase. Interestingly, concurrent LTD in the lateral perforant path did not significantly differ across strains or circadian cycle. Testing HFS protocols during the dark phase revealed that theta burst stimulation (100 Hz bursts at 5 Hz intervals) was ineffective in eliciting either LTP or concurrent LTD in DG, whereas 400 Hz bursts delivered at theta (5 Hz) or delta (1 Hz) frequencies produced substantial LTP and concurrent LTD. Thus, these natural and experimental factors regulate granule cell excitability, and differentially affect LTP and concurrent LTD in the DG of freely moving rats. © 2011 Wiley Periodicals, Inc.
Novel Methods for Surface EMG Analysis and Exploration Based on Multi-Modal Gaussian Mixture Models

This paper introduces a new method for data analysis of animal muscle activation during locomotion. It is based on fitting Gaussian mixture models (GMMs) to surface EMG data (sEMG). This approach enables researchers/users to isolate parts of the overall muscle activation within locomotion EMG data. Furthermore, it provides new opportunities for analysis and exploration of sEMG data by using the resulting Gaussian modes as atomic building blocks for a hierarchical clustering. In our experiments, composite peak models representing the general activation pattern per sensor location (one sensor on the long back muscle, three sensors on the gluteus muscle on each body side) were identified per individual for all 14 horses during walk and trot in the present study. Hereby we show the applicability of the method to identify composite peak models, which describe activation of different muscles throughout cycles of locomotion.
Diagnosis and control of epilepsy in the cat

SEIZURES are the one of the most common presentations in the neurological feline patient and can be a daunting prospect for the veterinary clinician. The list of possible differential diagnoses is huge and demands a careful and systematic diagnostic approach. This article steers the practitioner through the work-up and provides guidance on the provision and monitoring of antiepileptic drug therapy in cats.
Fusion helps diversification

A popular strategy for search result diversification is to first retrieve a set of documents utilizing a standard retrieval method and then rerank the results. We adopt a different perspective on the problem, based on data fusion. Starting from the hypothesis that data fusion can improve performance in terms of diversity metrics, we examine the impact of standard data fusion methods on result diversification. We take the output of a set of rankers, optimized for diversity or not, and find that data fusion can significantly improve state-of-the art diversification methods. We also introduce a new data fusion method, called diversified data fusion, which infers latent topics of a query using topic modeling, without leveraging outside information. Our experiments show that data fusion methods can enhance the performance of diversification and DDF significantly outperforms existing data fusion methods in terms of diversity metrics.
Adolescent Depression Prevention Toolkit

3 Introduction . 4 Background . 5 Review of the Literature . 8 Evidence Based Practice Model/Theoretical Framework . 15 Project Design . 16 Project Site and Population . 17 Setting Facilitators and barriers . 17 Goals, Objectives & Outcomes . 17 Implementation Plan/Procedures . 18 Intervention . 19 Evaluation. Data Collection and Analysis . 20 Ethical Considerations/Protection of Human Subjects . 20 Results . 21 Discussion . 27 Conclusion . 33 References . 37 Appendix A. Presentation Outline and Resources.48 B. IRB Approval Letter . 52 ADOLESCENT DEPRESSION PREVENTION TOOLKIT 3
Darwinian Evolution of Entrepreneurial Spirit and the Process of Development

This research suggests that a Darwinian evolution of entrepreneurial spirit played a significant role in the process of economic development and the evolution of inequality within and across societies. The study argues that entrepreneurial spirit evolved nonmonotonically in the course of human history. In early stages of development, the rise in income generated an evolutionary advantage to entrepreneurial, growth promoting traits and their increased representation accelerated the pace of technological advancements and the process of economic development. Natural selection therefore had magnified growth promoting activities in relatively wealthier economies as well as within the upper segments of societies, enlarging the income gap within as well as across societies. In mature stages of development, however, non-entrepreneurial individuals gained an evolutionary advantage, diminishing the growth potential of advanced economies and contribution to the convergence of the intermediate level economies to the advanced ones.
Current Progress and Challenges in the Search for Autism Biomarkers

Autism spectrum disorders (ASD) encompass a range of neurodevelopmental conditions that are clinically and etiologically very heterogeneous. ASD is currently diagnosed entirely on behavioral criteria, but intensive research efforts are focused on identifying biological markers for disease risk and early diagnosis. Here, we discuss recent progress toward identifying biological markers for ASD and highlight specific challenges as well as ethical aspects of translating ASD biomarker research into the clinic.
Wikipedia Link Structure and Text Mining for Semantic Relation Extraction

Wikipedia, a collaborative Wiki-based encyclopedia, has be- come a huge phenomenon among Internet users. It covers huge number of concepts of various fields such as Arts, Geography, History, Science, Sports and Games. Since it is becoming a database storing all human knowledge, Wikipedia mining is a promising approach that bridges the Semantic Web and the Social Web (a. k. a. Web 2.0). In fact, in the previ- ous researches on Wikipedia mining, it is strongly proved that Wikipedia has a remarkable capability as a corpus for knowledge extraction, espe- cially for relatedness measurement among concepts. However, semantic relatedness is just a numerical strength of a relation but does not have an explicit relation type. To extract inferable semantic relations with ex- plicit relation types, we need to analyze not only the link structure but also texts in Wikipedia. In this paper, we propose a consistent approach of semantic relation extraction from Wikipedia. The method consists of three sub-processes highly optimized for Wikipedia mining; 1) fast pre- processing, 2) POS (Part Of Speech) tag tree analysis, and 3) mainstay extraction. Furthermore, our detailed evaluation proved that link struc- ture mining improves both the accuracy and the scalability of semantic relations extraction.
Social change through an urban sport for development initiative? Investigating critical pedagogy through the voices of young people

ABSTRACT This article explores the pedagogy of an urban Sport for Development (SfD) initiative in Belgium through the voices of young people. We draw on the critical pedagogy of Paulo Freire, and use qualitative research methods (i.e. observations, informal conversations, in-depth interviews and sharing circles) over a three-year period, to analyse the initiative’s actual pedagogical practice with key Freirean concepts (i.e. ‘banking education’, ‘dialogue’ and ‘dialogical action’) and virtues (e.g. respect for people’s knowledge, rejection of discrimination, caring for people). The findings reveal the presence of several Freirean virtues, emerging dialogue and, for some, action thought. Still, the SfD initiative remains at considerable distance from fully-fledged critical pedagogy. The young people in the SfD initiative nonetheless experience it as a space where they can be themselves, feel at home, gain respect, can learn to reflect and form opinions, and are temporarily freed from daily struggles such as discrimination. We discuss several pathways that could foster the capacity to organise and deliver a programme beyond emerging dialogue and action.
DEVELOPMENT OF ASSESSMENT FOR POTENTIALLY TOXIC ELEMENT CONTAMINATION INDICATOR IN CLOSED LANDFILLS AND PROSPECTIVE GEOSTATISTICAL ANALYSIS

Post-closure management of landfill in Malaysia does not include assessment of the contaminant level in abiotic and biotic factors that inhabit the aged topsoil of closed landfills. Considering the bioaccumulation effect in the ecosystem, post-closure classification with the status of contaminant concentration below the permitted level does not promise safe closure to the ecosystem as time passes. Thus, substantial and constant qualitative analysis of contaminant concentration needs to be developed for sustainable management of landfill post-closure. In this work, heavy metals in common constituents (abiotic and biotic factors) of closed landfills were selected; that is, soil, stagnant water, and common communities of plant species in closed landfills in Selangor, both sanitary and non-sanitary, were studied. The results of the analysis demonstrated that the concentration of Cd was not detected in the soil of both landfills but the highest concentration was present in the leaves of Ageratum conyzoides compared to other plant species at both study sites. A parallel situation was discovered for the non-detection of Cd concentration in stagnant water at Ampar Tenang landfill, but the leaves of A. conyzoides contained this element. The sensitivity and affinity of A. conyzoides for accumulating heavy metals in this study were revealed particularly for Cd. Hence, this study suggests the use of A. conyzoides as a promising trace metals contamination indicator for closed urban landfills. Additionally, Guess-Field Kriging is believed to be a useful geostatistical tool to interpolate potential contamination area by utilising the abiotic and biotic factors as assistant variable to the target variable i.e. soil.
On the nonexistence of time dependent global weak solutions to the compressible Navier-Stokes equations

In this paper we prove the nonexistence of global weak solutions to the compressible Navier-Stokes equations for the isentropic gas in $\Bbb R^N, N\geq 3,$ where the pressure law given by $p(\rho)=a\rho^{\gamma}, $ $a>0, 1 0$, then there exists no finite energy global weak solution which satisfies the integrability conditions $ \rho |x|^2 \in L^1_{\mathrm{loc}} (0, \infty; L^1 (\Bbb R^N))$ and $ v\in L^1_{\mathrm{loc}} (0, \infty; L^{\frac{N}{N-1}} (\Bbb R^N))$.
Variations in the branching pattern of the aortic arch: an African perspective

Variation in the branches of the aortic arch is higher in individuals of African descent. However, published studies are few. The aims were to document variations in the branching pattern of the aortic arch in a South African sample, determine whether these variants are more common than other populations, and determine whether there are any significant differences in the prevalence of variation between males and females. The aortic arch and main branches were dissected in 733 cadavers. All branching patterns were documented and classified as types. Chi-Square tests were used to determine whether there were any significant differences in prevalence of variation between males and females. The diameters of the main branches were measured and compared between sexes.The standard branching pattern was present in 65% of individuals, similar to that reported for other African studies, but lower than other studies from around the world. Variations were more prevalent in males than in females (p = 0.025), while only the diameter of the left vertebral artery, when arising from the arch was significantly larger in females, with no differences between sexes for the other vessel diameters. The results of this study support the hypothesis that variations in the branching pattern of the aortic arch are more common in African individuals. These individuals may be at increased risk of associated although rare, clinical symptoms or iatrogenic injury.
Experiments with Citation Mining and Key-Term Extraction for Prior Art Search

This technical note presents the system built for the IP track of CLEF 2010 based on PATATRAS (PATent and Article Tracking, Retrieval and AnalysiS), the modular search infrastructure initially realized for CLEF IP 2009. We largely reused the system of the previous CLEF IP but at a relatively smaller scale and with the improvement of three main components: • A new citation mining tool based on Conditional Random Fields (CRF). • A key-term extraction module developed for technical and scientific documents and adapted to patent document structures using a vast ranges of metrics, features and a bagged decision tree. • An improvement of our multi-domain terminological database called GRISP. We used the Okapi BM25 and the Indri retrieval models for the prior art task and a KNN model for the automatic classification task under the IPC subclasses. In both tasks, specific final re-ranking techniques were used, including multiple regression models based on SVM. Although the Prior Art task was more challenging and we used a more limited number of retrieval models, we maintained similar results as last year. We performed, however, miserably at the classification task, and we consider that an instance-based KNN algorithm is not competitive with standard classifiers based on preliminary large scale training.
Structural, Optical and Electrical Properties of PVA/PANI/Nickel Nanocomposites Synthesized by Gamma Radiolytic Method

This article reports a simultaneous synthesis of polyaniline (PANI) and nickel (Ni) nanoparticles embedded in polyvinyl alcohol (PVA) film matrix by gamma radiolytic method. The mechanism of formation of PANI and Ni nanoparticles were proposed via oxidation of aniline and reduction of Ni ions, respectively. The effects of dose and Ni ions concentration on structural, optical, and electrical properties of the final PVA/PANI/Ni nanocomposites film were carefully examined. The structural and morphological studies show the presence of PANI with irregular granular microstructure and Ni nanoparticles with spherical shape and diameter less than 60 nm. The average particle size of Ni nanoparticles decreased with increasing dose and decreasing of precursor concentration due to increase of nucleation process over aggregation process during gamma irradiation. The optical absorption spectra showed that the absorption peak of Ni nanoparticles at about 390 nm shifted to lower wavelength and the absorbance increased with increasing dose. The formation of PANI was also revealed at 730 nm absorption peak with the absorbance increasing by the increase of dose. The electrical conductivity increased with increasing of dose and chlorine concentration due to number of polarons formation increases in the PVA/PANI/Ni nanocomposites.
The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion

ABSTRACT Protein arginine methyl transferase 5 (Prmt5) regulates various differentiation processes, including adipogenesis. Here, we investigated adipogenic conversion in cells and mice in which Copr5, a Prmt5- and histone-binding protein, was genetically invalidated. Compared to control littermates, the retroperitoneal white adipose tissue (WAT) of Copr5 KO mice was slightly but significantly reduced between 8 and 16 week/old and contained fewer and larger adipocytes. Moreover, the adipogenic conversion of Copr5 KO embryoid bodies (EB) and of primary embryo fibroblasts (Mefs) was markedly delayed. Differential transcriptomic analysis identified Copr5 as a negative regulator of the Dlk-1 gene, a Wnt target gene involved in the control of adipocyte progenitors cell fate. Dlk-1 expression was upregulated in Copr5 KO Mefs and the Vascular Stromal Fraction (VSF) of Copr5 KO WAT. Chromatin immunoprecipitation (ChIP) show that the ablation of Copr5 has impaired both the recruitment of Prmt5 and &bgr;-catenin at the Dlk-1 promoter. Overall, our data suggest that Copr5 is involved in the transcriptional control exerted by the Wnt pathway on early steps of adipogenesis.
On equivalences of database schemes

One of the fundamental questions in relation theory is the issue of equivalence between two database schemes. In [BMSU] two such schemes were defined to be equivalent when they have the same set of fixed points under the project-join maps associated with the two schemes. This definition requires in an explicit manner the existence of common universal relations, namely the joins, through which the two schemes exchange information, and the resulting “fiipoint” equivalence is a strong one: Both database schemes are in one-to-one correspondence with the subfamily of universal relations, the joins.
Biological ageing and frailty markers in breast cancer patients

Older cancer patients are a highly heterogeneous population in terms of global health and physiological reserves, and it is often difficult to determine the best treatment. Moreover, clinical tools currently used to assess global health require dedicated time and lack a standardized end score. Circulating markers of biological age and/or fitness could complement or partially substitute the existing screening tools. In this study we explored the relationship of potential ageing/frailty biomarkers with age and clinical frailty. On a population of 82 young and 162 older non-metastatic breast cancer patients, we measured mean leukocyte telomere length and plasma levels of interleukin-6 (IL-6), regulated upon activation, normal T cell expressed and secreted (RANTES), monocyte chemotactic protein 1 (MCP-1), insulin-like growth factor 1 (IGF-1). We also developed a new tool to summarize clinical frailty, designated Leuven Oncogeriatric Frailty Score (LOFS), by integrating GA results in a single, semi-continuous score. LOFS' median score was 8, on a scale from 0=frail to 10=fit. IL-6 levels were associated with chronological age in both groups and with clinical frailty in older breast cancer patients, whereas telomere length, IGF-1 and MCP-1 only correlated with age. Plasma IL-6 should be further explored as frailty biomarker in cancer patients.
Chandra observations of RX J1347.5−1145: the distribution of mass in the most X-ray-luminous galaxy cluster known

We present Chandra observations of RX J1347.5−1145, the most X-ray-luminous cluster of galaxies known. We report the discovery of a region of relatively hot, bright X-ray emission, located approximately 20 arcsec to the south-east of the main X-ray peak at a position consistent with the region of enhanced Sunyaev‐Zel’dovich effect reported recently by Komatsu et al. We suggest that this region contains shocked gas resulting from a recent subcluster merger event. Excluding the data for the south-east quadrant, the cluster appears relatively relaxed. The X-ray gas temperature rises from kT ∼ 6 keV within the central 25 h −1 kpc radius to a mean value of ∼16 keV between 0.1 and 0.5 h −1 Mpc. The mass profile for the relaxed regions of the cluster, determined under the assumption of hydrostatic equilibrium, can be parametrized by a Navarro, Frenk and White model with a scale radius rs ∼ 0.4 h −1 Mpc and a concentration parameter c ∼ 6. The best-fitting Chandra mass model is in good agreement with independent measurements from weak gravitational lensing studies. Strong lensing data for the central regions of the cluster can also be explained by the introduction of an additional mass clump centred on the second brightest galaxy. We argue that this galaxy is likely to have been the dominant galaxy of the recently merged subcluster.
A systematic and practical approach to generating policies from service level objectives

In order to manage a service to meet the agreed upon SLA, it is important to design a service of the required capacity and to monitor the service thereafter for violations at runtime. This objective can be achieved by translating SLOs specified in the SLA into lower-level policies that can then be used for design and enforcement purposes. Such design and operational policies are often constraints on thresholds of lower level metrics. In this paper, we propose a systematic and practical approach that combines fine-grained performance modeling with regression analysis to translate service level objectives into design and operational policies for multi-tier applications. We demonstrate that our approach can handle both request-based and session-based workloads and deal with workload changes in terms of both request volume and transaction mix. We validate our approach using both the RUBiS e-commerce benchmark and a trace-driven simulation of a business-critical enterprise application. These results show the effectiveness of our approach.