Miracle-dz/UniFAR-FTUs huggingface dataset:
Why Do Aftershocks Occur Within the Rupture Area of a Large Earthquake?

The mainshock‐aftershock sequence is one of the fundamental characteristics of seismogenesis, yet the physical mechanism of aftershock generation remains poorly understood. The simple explanation that aftershocks are caused by the mainshock's redistribution of strain energy is not always applicable, especially for aftershocks within the mainshock slip area, where strain energy is released. Here we show that the genesis of aftershocks can be modeled using a frictionally heterogeneous fault system. We conducted quasi‐dynamic numerical simulations of fault rupture cycles on a finite fault governed by a rate‐ and state‐dependent friction law. Aftershocks are observed around and within the mainshock rupture area when the frictional heterogeneity varies significantly along the fault. On the other hand, aftershocks are not produced when along‐fault variations in the frictional heterogeneity are small, which mimics the observed lack of aftershocks for repeating earthquakes.
Arylamine-DNA adducts in vitro and in vivo: their role in bacterial mutagenesis and urinary bladder carcinogenesis

Hepatic N-oxidation, followed by N-glucuronidation, has been proposed as a route of metabolic activation for arylamine bladder carcinogens. It is postulated that the N-glucuronides are transported to the bladder lumen where they are hydrolyzed under slightly acidic conditions to release direct-acting carcinogenic and mutagenic N-hydroxyarylamines. In this study, 4-aminobiphenyl (ABP), 1-naphthylamine (1-NA), 2-naphthylamine (2-NA), 2-acetylaminofluorene (AAF), 4-nitrobiphenyl (NBP), benzidine (BZ), and N-acetylbenzidine (ABZ) were administered to male beagle dogs (60 μmole/kg), and the bladder epithelium DNA adducts were quantified at various times after treatment. At 24-48 hr after administration, the order of binding to bladder epithelium DNA was: ABP >> AAF > NBP ≅ 2-NA≅BZ ≅ ABZ >> 1-NA. The level of DNA modification by ABP remained constant for 7 days, whereas 2-NA and AAF residues decreased by 35% and 80%, respectively. The extent and relative persistence of total DNA binding correlated with the compounds' ability to induce bladder tumors in dogs. ABP, AAF, NBP, 2-NA and ABZ administration resulted in DNA binding sufficient for adduct analysis. Enzymatic hydrolysis of the DNA and examination of the adducts by high pressure liquid chromatography indicated that arylamine substitution at C8 of deoxyguanosine was the dominant product. Additional adducts were detected in animals treated with ABP, NBP, and 2-NA. Furthermore, the profiles of adducts obtained in vivo were remarkably similar to the profiles obtained when the N-hydroxy arylamine metabolites of these carcinogens were reacted with DNA in vitro at pH 5.0. To evaluate the mutagenic potential of these arylamine-DNA adducts, Salmonella typhimurium strains TA 1535 and TA 1538 were incubated with N-hydroxy-2-NA, N-hydroxy-2-aminofluorene (AF), N-hydroxy-ABP, and N-hydroxy-ABZ and the resulting DNA adducts and reversions were quantified. Arylamine-C8-deoxyguanosine substitution was correlated with frameshift reversions induced by these agents, with the lesions showing a relative order of mutagenic efficiency of ABZ>AF≅2-NA>ABP. These data suggest that mutagenic N-hydroxyarylamines may be ultimate carcinogens for the bladder epithelium. Furthermore, if one assumes that a mutagenic lesion is important for tumor initiation, then C8-deoxyguanosine substitution by these compounds may be significant for urinary bladder carcinogenesis.
Selective radiation of hematolymphoid tissue delivered by anti-CD45 antibody.

The ability to deliver radiation selectively to lymphohematopoietic tissues may have utility in conditions treated by myeloablative regimens followed by bone marrow transplantation. Since the CD45 antigen is the most broadly expressed of hematopoietic antigens, we examined the biodistribution of radiolabeled anti-CD45 monoclonal antibodies in normal mice. Trace 125I or 131I-labeled monoclonal antibodies 30G12 (rat IgG2a), 30F11 (rat IgG2b), and F(ab')2 fragments of 30F11 were injected i.v. at doses of 5 to 1000 micrograms. For both intact antibodies, a higher percentage of injected dose/g (% ID/g tissue) in blood was achieved with higher antibody doses. However, as the dose of antibody was increased, the % ID/g in the target organs of spleen, marrow, and lymph nodes decreased. At doses between 5 and 10-micrograms, % ID/g in these tissues exceeded that in lung, the normal organ with the highest concentration of radiolabel. In contrast, thymus was the only hematopoietic organ in which the % ID/g increased with increasing antibody dose, although at high dose the % ID/g was still far below that achieved in the other hematopoietic organs. Antibody 30F11 F(ab')2 fragments were cleared more quickly than intact antibody from blood and from both target and nontarget organs, although the relationship between increasing antibody dose and decreasing % ID/g in spleen, marrow, and lymph nodes was observed. The time-activity curves for each dose of antibody were used to calculate estimates of radiation absorbed dose to each organ. At the 10-micrograms dose of 30G12, the spleen was estimated to receive a radiation dose that was 13 times more than lung, the lymph nodes 3 to 4 times more, and the bone marrow 3 times more than lung. For each antibody fragment dose, the radiation absorbed dose per MBq 131I administered was lower because the residence times of the fragments were shorter than those of the intact antibody. Thus these estimates suggested that the best "therapeutic ratio" of radiation delivered to target organ as compared to lung was achieved with lower doses of intact antibody. We have demonstrated that radiolabeled anti-CD45 monoclonal antibodies can deliver radiation to lymphohematopoietic tissues with relative selectivity and that the relative uptake and retention in different hematolymphoid tissues change with increasing antibody dose.
A single amino acid determines the subunit-specific spider toxin block of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels.

Joro spider toxin (JSTX) is one of the most potent antagonists of glutamatergic AMPA/KA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate) receptor channels in invertebrates and vertebrates. A differential blocking effect on certain types of glutamatergic synapses--e.g., parallel and climbing fiber synaptic inputs to rat cerebellar Purkinje neurons--has been shown by using a synthetic analog of the spider toxin. By investigating the molecular basis of the JSTX action on the recombinant AMPA/KA receptors GluR1-GluR4 and GluR6 expressed in Xenopus oocytes, we found that submicromolar concentrations of JSTX exert a subunit-specific block. Thus, receptor subunits forming a receptor channel with a linear current-voltage (I-V) relationship (GluR1/2, GluR2/3, and GluR6) were not affected, while receptor subunits with rectifying I-V relationships (GluR1, GluR3, GluR4, and GluR1/3) were reversibly blocked by JSTX. By using receptor-subunit mutants obtained by site-directed mutagenesis, we have identified a single amino acid position (glutamine in the proposed second transmembrane domain) that is critical for the JSTX block. Since this site has previously been shown to control the I-V relationship of the AMPA/KA receptor channel and to participate in the regulation of the channel's permeability for calcium ions, our findings suggest that JSTX binds close to the central pore region of the channel.
Glimpse: Continuous, Real-Time Object Recognition on Mobile Devices

Glimpse is a continuous, real-time object recognition system for camera-equipped mobile devices. Glimpse captures full-motion video, locates objects of interest, recognizes and labels them, and tracks them from frame to frame for the user. Because the algorithms for object recognition entail significant computation, Glimpse runs them on server machines. When the latency between the server and mobile device is higher than a frame-time, this approach lowers object recognition accuracy. To regain accuracy, Glimpse uses an active cache of video frames on the mobile device. A subset of the frames in the active cache are used to track objects on the mobile, using (stale) hints about objects that arrive from the server from time to time. To reduce network bandwidth usage, Glimpse computes trigger frames to send to the server for recognizing and labeling. Experiments with Android smartphones and Google Glass over Verizon, AT&T, and a campus Wi-Fi network show that with hardware face detection support (available on many mobile devices), Glimpse achieves precision between 96.4% to 99.8% for continuous face recognition, which improves over a scheme performing hardware face detection and server-side recognition without Glimpse's techniques by between 1.8-2.5×. The improvement in precision for face recognition without hardware detection is between 1.6-5.5×. For road sign recognition, which does not have a hardware detector, Glimpse achieves precision between 75% and 80%; without Glimpse, continuous detection is non-functional (0.2%-1.9% precision).
NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ

ABSTRACT NF-κB2 (p100/p52), a member of the NF-κB/Rel family of transcription factors, is involved in the regulation of a variety of genes important for immune function. Previously, we have shown that the NF-κB2 gene is regulated in a positive and a negative manner. Two κB elements within the NF-κB2 promoter mediate tumor necrosis factor alpha-inducible transactivation. In addition, we have shown that there exists a transcriptional repression in the absence of NF-κB. To identify a DNA binding activity responsible for this transcriptional repression, we have partially purified a nuclear complex, named Rep-κB. Here we further analyze this putative repressive binding activity. Detailed examination of Rep-κB–DNA interaction revealed the sequence requirements for binding to be almost identical to those of recombination signal binding protein Jκ (RBP-Jκ), the mammalian homolog of the protein encoded by Drosophila suppressor of hairless [Su(H)]. In addition, in electromobility shift assays, Rep-κB binding activity is recognized by an antibody directed against RBP-Jκ. By performing transient-transfection assays, we show that human RBP-Jκ represses basal as well as RelA (p65)-stimulated NF-κB2 promoter activity. Studies in Drosophila melanogaster have shown that Su(H) is implicated in the Notch signaling pathway regulating cell fate decisions. In transient-transfection assays we show that truncated Notch-1 strongly induces NF-κB2 promoter activity. In summary, our data clearly demonstrate that Rep-κB is closely related or identical to RBP-Jκ. RBP-Jκ is a strong transcriptional repressor of NF-κB2. Moreover, this repression can be overcome by activated Notch-1, suggesting that NF-κB2 is a novel putative Notch target gene.
Prevalence and correlates of environmental tobacco smoke exposure among adolescents in Mongolia.

OBJECTIVE To estimate the prevalence and identify correlates of environmental tobacco exposure (ETS) among adolescents in Mongolia. METHODS A cross-sectional study was carried out in 2003 in Mongolia within the framework of the Global Youth Tobacco Survey. Information was obtained on exposure to Environmental tobacco smoke (ETS) in the home and outside home, parental and peer smoking. Demographic characteristics such as age and sex were also obtained. Data were analyzed to obtain frequencies of characteristics. Logistic regression analysis was conducted to assess the association between ETS and relevant predictor variables. RESULTS 73.9% (71.6%-76.1%) males and 71.7% (69.7%-73.7%) females reported being exposed to ETS either in the home or elsewhere. The odds of exposure were 5.85 (3.83-8.92) if both parents were smokers, 3.65(3.10-4.30) if only father smoked and 6.54 (3.48-12.32) if only mother smoked. Older adolescents were more likely to be exposed to ETS than younger adolescents. Prevalence of exposure to ETS within the home was similar between males and females but males had a higher prevalence of exposure outside of the home than females (50.7% and 42.4% respectively (p < 0.001). Overall proportion of adolescents exposed to ETS in the home was higher than those exposed outside suggesting that domestic exposure was the main form of ETS among adolescents in Mongolia. CONCLUSION Exposure to environmental tobacco smoke is high among school going adolescents in Mongolia. Public health interventions aimed to reduce morbidity from tobacco among adolescents should also accord particular attention toward environmental tobacco smoke.
The Retinotopic Organization of the Human Middle Temporal Area MT/V5 and Its Cortical Neighbors

Although there is general agreement that the human middle temporal (MT)/V5+ complex corresponds to monkey area MT/V5 proper plus a number of neighboring motion-sensitive areas, the identification of human MT/V5 within the complex has proven difficult. Here, we have used functional magnetic resonance imaging and the retinotopic mapping technique, which has very recently disclosed the organization of the visual field maps within the monkey MT/V5 cluster. We observed a retinotopic organization in humans very similar to that documented in monkeys: an MT/V5 cluster that includes areas MT/V5, pMSTv (putative ventral part of the medial superior temporal area), pFST (putative fundus of the superior temporal area), and pV4t (putative V4 transitional zone), and neighbors a more ventral putative human posterior inferior temporal area (phPIT) cluster. The four areas in the MT/V5 cluster and the two areas in the phPIT cluster each represent the complete contralateral hemifield. The complete MT/V5 cluster comprises 70% of the motion localizer activation. Human MT/V5 is located in the region bound by lateral, anterior, and inferior occipital sulci and occupies only one-fifth of the motion complex. It shares the basic functional properties of its monkey homolog: receptive field size relative to other areas, response to moving and static stimuli, as well as sensitivity to three-dimensional structure from motion. Functional properties sharply distinguish the MT/V5 cluster from its immediate neighbors in the phPIT cluster and the LO (lateral occipital) regions. Together with similarities in retinotopic organization and topological neighborhood, the functional properties suggest that MT/V5 in human and macaque cortex are homologous.
Reconstructing thermal properties of firn at Summit, Greenland, from a temperature profile time series

We have constrained the value for thermal diffusivity of near-surface snow and firn at Summit Station, Greenland, using a Fourier-type analysis applied to hourly temperature measurements collected from eight thermistors in a closed-off, air-filled borehole between May 2004 and July 2008. An implicit, finite-difference method suggests that a bulk diffusivity of ∼25 ± 3m2 a−1 is the most reasonable for representing macroscale heat transport in the top 30 m of firn and snow. This value represents an average diffusivity and, in a conduction-only model, generates temperature series whose phase shifts with depth most closely match those of the Summit borehole data (rms difference between measurements and model output is ∼6 days). This bulk value, derived numerically and corroborated analytically, is useful over large tracts of the Greenland ice sheet where density and microstructure are unknown.
Specific microbial gene abundances and soil parameters contribute to C, N, and greenhouse gas process rates after land use change in Southern Amazonian Soils

Ecological processes regulating soil carbon (C) and nitrogen (N) cycles are still poorly understood, especially in the world’s largest agricultural frontier in Southern Amazonia. We analyzed soil parameters in samples from pristine rainforest and after land use change to pasture and crop fields, and correlated them with abundance of functional and phylogenetic marker genes (amoA, nirK, nirS, norB, nosZ, nifH, mcrA, pmoA, and 16S/18S rRNA). Additionally, we integrated these parameters using path analysis and multiple regressions. Following forest removal, concentrations of soil C and N declined, and pH and nutrient levels increased, which influenced microbial abundances and biogeochemical processes. A seasonal trend was observed, suggesting that abundances of microbial groups were restored to near native levels after the dry winter fallow. Integration of the marker gene abundances with soil parameters using path analysis and multiple regressions provided good predictions of biogeochemical processes, such as the fluxes of NO3, N2O, CO2, and CH4. In the wet season, agricultural soil showed the highest abundance of nitrifiers (amoA) and Archaea, however, forest soils showed the highest abundances of denitrifiers (nirK, nosZ) and high N, which correlated with increased N2O emissions. Methanogens (mcrA) and methanotrophs (pmoA) were more abundant in forest soil, but methane flux was highest in pasture sites, which was related to soil compaction. Rather than analyzing direct correlations, the data integration using multivariate tools provided a better overview of biogeochemical processes. Overall, in the wet season, land use change from forest to agriculture reduced the abundance of different functional microbial groups related to the soil C and N cycles; integrating the gene abundance data and soil parameters provided a comprehensive overview of these interactions. Path analysis and multiple regressions addressed the need for more comprehensive approaches to improve our mechanistic understanding of biogeochemical cycles.
Markov Chain Monte Carlo Estimation of Exponential Random Graph Models

This paper is about estimating the parameters of the exponential random graph model, also known as the p∗ model, using frequentist Markov chain Monte Carlo (MCMC) methods. The exponential random graph model is simulated using Gibbs or MetropolisHastings sampling. The estimation procedures considered are based on the Robbins-Monro algorithm for approximating a solution to the likelihood equation. A major problem with exponential random graph models resides in the fact that such models can have, for certain parameter values, bimodal (or multimodal) distributions for the sufficient statistics such as the number of ties. The bimodality of the exponential graph distribution for certain parameter values seems a severe limitation to its practical usefulness. The possibility of bior multimodality is reflected in the possibility that the outcome space is divided into two (or more) regions such that the more usual type of MCMC algorithms, updating only single relations, dyads, or triplets, have extremely long sojourn times within such regions, and a negligible probability to move from one region to another. In such situations, convergence to the target distribution is extremely slow. To be useful, MCMC algorithms must be able to make transitions from a given graph to a very different graph. It is proposed to include transitions to the graph complement as updating steps to improve the speed of convergence to the target distribution. Estimation procedures implementing these ideas work satisfactorily for some data sets and model specifications, but not for all.
Mineral paragenesis on Mars: The roles of reactive surface area and diffusion

Geochemical models of secondary mineral precipitation on Mars generally assume semiopen systems (open to the atmosphere but closed at the water‐sediment interface) and equilibrium conditions. However, in natural multicomponent systems, the reactive surface area of primary minerals controls the dissolution rate and affects the precipitation sequences of secondary phases, and simultaneously, the transport of dissolved species may occur through the atmosphere‐water and water‐sediment interfaces. Here we present a suite of geochemical models designed to analyze the formation of secondary minerals in basaltic sediments on Mars, evaluating the role of (i) reactive surface areas and (ii) the transport of ions through a basalt sediment column. We consider fully open conditions, both to the atmosphere and to the sediment, and a kinetic approach for mineral dissolution and precipitation. Our models consider a geochemical scenario constituted by a basin (i.e., a shallow lake) where supersaturation is generated by evaporation/cooling and the starting point is a solution in equilibrium with basaltic sediments. Our results show that cation removal by diffusion, along with the input of atmospheric volatiles and the influence of the reactive surface area of primary minerals, plays a central role in the evolution of the secondary mineral sequences formed. We conclude that precipitation of evaporites finds more restrictions in basaltic sediments of small grain size than in basaltic sediments of greater grain size.
Word Embeddings with Multiple Word Prototypes

The project deals with the problem of construction of multiple sense embeddings for different words. We develop several models to tackle the problem consisting of online clustering Methods, methods involving parameter estimation and also look at methods related to word word co-occurrence matrices. The training data used is the April 2010 snapshot of the Wikipedia corpus [18]. Our model uses the popular Word2vec tool [1] to compute single word embeddings. We compare the performance of our approaches with current state of the art models [9] [14]and find that our model is comparable to the state of the art models and even outperforms them in some cases. Our model is extremely efficient and takes less than 6 hours for complete training and computation of senses. We also discuss the possibility of our model giving better (semantically coherent) senses than present models. The main task used for comparing the models is the SCWS task [9]. The comparisons have been done using human judgment of semantic similarity. Under the guidance of Dr. Amitabha Mukherjee Indian Institute of Technology, Kanpur
Modifikasi Resipren dan Bitumen Dalam Peningkatan Kekuatan Aspal

Modifikasi Resipren dan Bitumen dalam Peningkatan Kekuatan Aspal telah dilakukan. Aspal modifier dibuat dalam 7 jenis variasi perbandingan aspal, bitumen, dengan resipren yang telah dilarutkan dengan toluene sebesar 75:20:5 ; 70:20:10 ; 65:20:15 ; 60:20:20 ; 55:20:25 (v/v/b) dalam 100 mL, penambahan agregat pasir halus 300 gram dan agregat kasar kerikil 50 gram, dan diproses dalam ekstruder pada suhu 150oC. Sifat mekanik dan sifat termal aspal modifier yang diuji meliputi kuat tekan, daya serap air, morfologi dengan TEM. Hasil karakterisasi menunjukkan bahwa campuran aspal, bitumen, dan resipren dengan perbandingan 55 : 20 : 25 efektif dalam meningkatkan sifat mekanis dari campuran aspal dimana dihasilkan kekuatan tekan maksimum sebesar 0,974 mPa. Sifat fisik menghasilkan penyerapan air sebesar 0,63%. Hasil uji morfologi dengan TEM memperlihatkan adanya perbedaan setelah bitumen ditambahkan kedalam campuran aspal dan resipren. Recipient and bitumen modifications in asphalt strengthening had been carried out. Asphalt modifier was made in 7 types of comparison of asphalt, bitumen variation, with recipient (dissolved with toluene by 75: 20: 5; 70:20:10; 65:20:15; 60:20:20; 55:20:25 (v/v/b) in 100 mL), 300 grams of fine sand aggregate and 50 grams of coarse gravel aggregate; then processed in an extruder at 150oC. The mechanical properties and thermal properties of the modifier test included compressive strength, water absorption, and morphology with TEM. The characterization results showed that asphalt, bitumen and recipient mixtures with a ratio of 55: 20: 25 were effective in increasing the mechanical properties of the asphalt mixture where the maximum compressive strength was 0.974 mPa. Physical properties produced water absorption of 0.63%. The results of morphological tests with TEM showed that there was a difference after bitumen was added to the asphalt and recipient mixture.