Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling the effects of fire severity and climate warming on active layer thickness and soil carbon storage of black spruce forests across the landscape in interior Alaska

There is a substantial amount of carbon stored in the permafrost soils of boreal forest ecosystems, where it is currently protected from decomposition. The surface organic horizons insulate the deeper soil from variations in atmospheric temperature. The removal of these insulating horizons through consumption by fire increases the vulnerability of permafrost to thaw, and the carbon stored in permafrost to decomposition. In this study we ask how warming and fire regime may influence spatial and temporal changes in active layer and carbon dynamics across a boreal forest landscape in interior Alaska. To address this question, we (1) developed and tested a predictive model of the effect of fire severity on soil organic horizons that depends on landscape-level conditions and (2) used this model to evaluate the long-term consequences of warming and changes in fire regime on active layer and soil carbon dynamics of black spruce forests across interior Alaska. The predictive model of fire severity, designed from the analysis of field observations, reproduces the effect of local topography (landform category, the slope angle and aspect and flow accumulation), weather conditions (drought index, soil moisture) and fire characteristics (day of year and size of the fire) on the reduction of the organic layer caused by fire. The integration of the fire severity model into an ecosystem process-based model allowed us to document the relative importance and interactions among local topography, fire regime and climate warming on active layer and soil carbon dynamics. Lowlands were more resistant to severe fires and climate warming, showing smaller increases in active layer thickness and soil carbon loss compared to drier flat uplands and slopes. In simulations that included the effects of both warming and fire at the regional scale, fire was primarily responsible for a reduction in organic layer thickness of 0.06 m on average by 2100 that led to an increase in active layer thickness of 1.1 m on average by 2100. The combination of warming and fire led to a simulated cumulative loss of 9.6 kgC m−2 on average by 2100. Our analysis suggests that ecosystem carbon storage in boreal forests in interior Alaska is particularly vulnerable, primarily due to the combustion of organic layer thickness in fire and the related increase in active layer thickness that exposes previously protected permafrost soil carbon to decomposition.
Comparison of AIRS/AMSU temperature and moisture retrievals with matched ERA-interim and radiosonde measurements over East China

The accuracy of the temperature and humidity profiles from the Atmospheric Infrared Sounder (AIRS) and Advanced Microwave Sounding Unit (AMSU) is evaluated using three month of collocated datasets over East China. The AIRS/AMSU retrievals, radiosonde data (RAOB), and the ERA-Interim data from European Center for medium Range Forecast (ECMWF) are used in this validation. This study also compares the AIRS/AMSU retrieved profiles with it only retrieved by AIRS. Results of the entire intercomparison reveal that the RMSE of temperature profiles are in very good agreement with all cases, whilst the relative humidity RMSE show larger difference. Compared with RAOB for the AIRS/AMSU retrievals and ERA-Interim data, it is found that the ERA-Interim temperature and humidity profiles are superior to AIRS retrievals except the humidity in upper troposphere. The accuracy of AIRS/AMSU retrievals is a little bit better than only AIRS retrieved profile product.
Comparative effectiveness study of breast-conserving surgery and mastectomy in the general population: A NCDB analysis

Purpose Recent studies have revealed that breast-conserving surgery (BCS) with radiotherapy (RT) led to better survival than mastectomy in some populations. We compared the efficacy of BCS+RT and mastectomy using the National Cancer Database (NCDB, USA). Methods Non-metastatic breast cancers in the NCDB from 2004–2011 were identified. The Kaplan-Meier method, Coxregression and propensity score analysis were used to compare the overall survival (OS) among patients with BCS+RT, mastectomy alone and mastectomy+RT. Results A total of 160,880 patients with a median follow-up of 43.4 months were included. The respective 8-year OS values were 86.5%, 72.3% and 70.4% in the BCS+RT, mastectomy alone and mastectomy+RT group, respectively (P < 0.001). After exclusion of patients with comorbidities, mastectomy (alone or with RT) remained associated with a lower OS in N0 and N1 patients. However, the OS of mastectomy+RT was equivalent to BCS+RT in N2–3 patients. Among patients aged 50 or younger, the OS benefit of BCS+RT over mastectomy alone was statistically significant (HR1.42, 95% CI 1.16–1.74), but not clinically significant (<5%) in N0 patients, whereas in N2–3 patients, the OS of BCS+RT was equivalent to mastectomy+RT (85.2% vs. 84.8%). The results of the propensity analysis were similar. Conclusions BCS+RT resulted in improved OS compared with mastectomy ± RT in N0 and N1 patients. In N2–3 patients, BCS+RT has an OS similar to mastectomy+RT when patients with comorbidities were excluded. Among patients aged 50 or younger, the OS of BCS+RT is equivalent to mastectomy ± RT.
Measuring clone based reengineering opportunities

Code duplication, plausibly caused by copying source code and slightly modifying it, is often observed in large systems. Clone detection and documentation have been investigated by several researchers in the past years. Recently, research focus has shifted towards the investigation of software and process restructuring actions based on clone detection. This paper presents an original definition of a clone classification scheme useful to assess and measure different system reengineering opportunities. The proposed classification considers each group of cloned methods in terms of the meaning of the differences existing between them. The algorithm used for automatic classification of clones is presented together with results obtained by classifying cloned methods and measuring reengineering opportunities in six freely available systems whose total size is about 500 KLOC of Java code.
Performance comparison of spectrum-slicing techniques employing SOA-based noise suppression at the transmitter or receiver

We compare three semiconductor optical amplifier (SOA)-based noise suppression approaches employed in incoherent light spectrum-sliced systems. Although the SOA at the transmitter provides the best absolute noise suppression, it is susceptible to performance degradation in the presence of optical filtering and dispersion. Using the SOA at the receiver can provide good performance while avoiding these limitations, and may provide better value in last-mile access applications.
Identification of Risk Factors for Vascular Thrombosis May Reduce Early Renal Graft Loss: A Review of Recent Literature

Renal graft survival has improved over the past years, mainly owing to better immunosuppression. Vascular thrombosis, though rare, therefore accounts for up to one third of early graft loss. We assess current literature on transplantation, identify thrombosis risk factors, and discuss means of avoiding thrombotic events and saving thrombosed grafts. The incidence of arterial thrombosis was reported to 0.2–7.5% and venous thrombosis 0.1–8.2%, with the highest incidence among children and infants, and the lowest in living donor reports. The most significant risk factors for developing thrombosis were donor-age below 6 or above 60 years, or recipient-age below 5-6 years, per- or postoperative hemodynamic instability, peritoneal dialysis, diabetic nephropathy, a history of thrombosis, deceased donor, or >24 hours cold ischemia. Multiple arteries were not a risk factor, and a right kidney graft was most often reported not to be. Given the thrombosed kidney graft is diagnosed in time, salvage is possible by urgent reoperation and thrombectomy. Despite meticulous attentions to reduce thrombotic risk factors, thrombosis cannot be entirely prevented and means to an early detection of this complication is desirable in order to save the kidneys through prompt reoperation. Microdialysis may be a new tool for this.
High-performance PTFE nanocomposites based on halloysite nanotubes

Abstract Halloysite nanotubes (HNTs)/polytetrafluoroethylene (PTFE) nanocomposites were prepared by the cold compression moulding method. The effects of addition of HNTs (HNTs ‘filling’) on the performances of PTFE were explored using X-ray diffraction, Fourier Transform infrared spectroscopy, scanning electron microscopy and thermogravimetric analysis which showed that HNTs were well dispersed in the PTFE matrix by means of physical mixing at lower contents of 2-5 wt. %; the introduction of HNTs into PTFE could improve the heat stability of the PTFE. Furthermore, the mechanical and tribological performances of the nanocomposites were measured to examine the filling effect. The tensile strength of the HNTs/PTFE nanocomposites at 2-5 wt. % HNTs content increased by ∼3.5% while their wear rates decreased by 55-90% relative to pure PTFE, clear proof of the filling effect of HNTs with a high aspect ratio.
Lightning and radar observations of two storms observed during STEPS

The Severe Thunderstorm Electrification and Precipitation Study (STEPS; Lang et al. 2004) field campaign took place between 17 May 2000 and 20 July 2000 in eastern Colorado and western Kansas. STEPS research aims to identify relationships between microphysics, dynamics and electrification in severe storms on the High Plains, and in particular, investigate positive cloud-toground (CG) lightning production. One specific scientific goal of STEPS, as outlined in the Scientific Overview, is “To understand the formation of precipitation and its influence on electrical development, especially in those storms producing large hail. ” This study focuses on that specific goal by contrasting kinematic, microphysical, and electrical characteristics of two STEPS cases: a positive CG-producing storm and a storm that produced no CG flashes.
Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions.

Chronic angina, a condition that impairs quality of life and is associated with decreased life expectancy, affects &6.4 million Americans.1 Current therapies that reduce angina frequency and nitrate consumption and increase the threshold at which demand-induced myocardial ischemic symptoms become evident include drugs (nitrates, β-blockers, calcium antagonists), exercise conditioning, enhanced external counterpulsation, and coronary revascularization.1–3 Several new investigational drugs are being tested for the treatment of chronic angina.4–9 This review will focus on sustained-release ranolazine, a drug that reduces angina symptoms, with a mechanism of action different from that of currently available pharmacological therapies.8–29 Ranolazine was approved on January 27, 2006, in the United States for use in patients with chronic angina who continue to be symptomatic on β-blockers, calcium antagonists, or nitrates. Ranolazine ([(+) N -(2,6-dimethylphenyl)-4(2-hydroxy-3-(2-methoxyphenoxy)-propyl)-1-piperazine acetamide dihydrochloride]) is an active piperazine derivative that was patented in 1986 and is available in an oral and intravenous form (Figure 1). The immediate-release ranolazine (not in current use) had an average terminal elimination half-life ranging from 1.4 to 1.9 hours and a 10-fold peak/trough difference with dosing of 240 to 400 mg 3 times per day.19 Early studies with immediate-release ranolazine provided evidence of antiischemic/antianginal properties in patients with chronic angina without clinically significant changes in heart rate or blood pressure and are reviewed elsewhere.20–24 Unless otherwise stated, the remainder of this review refers to sustained-release ranolazine. Figure 1. Chemical structure and metabolism of ranolazine. Reprinted with permission from J Clin Pharmacol . 2005;45:422–433.17 Ranolazine (Ranexa; CV Therapeutics Inc, Palo Alto, Calif) is manufactured in a sustained-release form that has a prolonged absorption phase with maximal plasma concentrations (Cmax) typically seen 4 to 6 hours after administration. The average terminal elimination half-life is &7 hours after multiple dosing to steady state, and the …
AN INFLAMMATION METER TO REVEAL THE PRESENCE AND EXTENT OF INFLAMMATION IN OLDER PATIENTS

and no significant difference in muscle area (Table 1) . We found a strong linear correlation between bone and muscle area in both groups of women (Figure 1). Women with osteoporotic fractures had bone areas lower than expected given their muscle areas. In linear regression analyses fitted separately for the two groups (Figure l), we found similar slopes (2.98 vs 2.73) but significantly different intercepts (32.29 vs 113.84; P < .0001). These findings suggest that the reduction in bone mass often observed in women with osteoporotic fractures is attributable to a primary bone-related pathophysiologic process. The bone/muscle ratio may help to identify women with true osteoporosis from those in whom reduction in bone mass is merely the consequence of severe sarcopenia in the context of ageassociated frailty and not a primary disturbance of bone metabolism.
Resistance Artery Creatine Kinase mRNA and Blood Pressure in Humans

Hypertension remains the main risk factor for cardiovascular death. Environmental and biological factors are known to contribute to the condition, and circulating creatine kinase was reported to be the main predictor of blood pressure in the general population. This was proposed to be because of high resistance artery creatine kinase-BB rapidly regenerating ATP for vascular contractility. Therefore, we assessed whether creatine kinase isoenzyme mRNA levels in human resistance arteries are associated with blood pressure. We isolated resistance-sized arteries from omental fat donated by consecutive women undergoing uterine fibroid surgery. Blood pressure was measured in the sitting position. Vessels of 13 women were included, 6 normotensive and 7 hypertensive, mean age 42.9 years (SE, 1.6) and mean systolic/diastolic blood pressure, 144.8 (8.0)/86.5 (4.3) mm Hg. Arteriolar creatine kinase isoenzyme mRNA was assessed using quantitative real-time polymerase chain reaction. Normalized creatine kinase B mRNA copy numbers, ranging from 5.2 to 24.4 (mean, 15.0; SE, 1.9), showed a near-perfect correlation with diastolic blood pressure (correlation coefficient, 0.9; 95% confidence interval, 0.6–1.0) and were well correlated with systolic blood pressure, with a 90% relative increase in resistance artery creatine kinase B mRNA in hypertensives compared with normotensives, normalized copy numbers were, respectively, 19.3 (SE, 2.0) versus 10.1 (SE, 2.1), P=0.0045. To our knowledge, this is the first direct evidence suggesting that resistance artery creatine kinase mRNA expression levels concur with blood pressure levels, almost doubling with hypertension. These findings add to the evidence that creatine kinase might be involved in the vasculature’s pressor responses.
Institutions influence preferences: Evidence from a common pool resource experiment

We model the dynamic effects of external enforcement on the exploitation of a common pool resource. Fitting our model to xperimental data we find that institutions influence social preferences. We solve two puzzles in the data: the increase and later rosion of cooperation when commoners vote against the imposition of a fine, and the high deterrence power of low fines. When nes are rejected, internalization of a social norm explains the increased cooperation; violations (accidental or not), coupled with eciprocal preferences, account for the erosion. Low fines stabilize cooperation by preventing a spiral of negative reciprocation. 2007 Elsevier B.V. All rights reserved.
Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man.

Although insulin stimulates protein synthesis and inhibits protein breakdown in skeletal muscle in vitro, the actual contribution of these actions to its anabolic effects in man remains unknown. Using the forearm perfusion method together with systemic infusion of L-[ring-2,6-3H]phenylalanine and L-[1-14C]leucine, we measured steady state amino acid exchange kinetics across muscle in seven normal males before and in response to a 2-h intraarterial infusion of insulin. Postabsorptively, the muscle disposal (Rd) of phenylalanine (43 +/- 5 nmol/min per 100 ml forearm) and leucine (113 +/- 13) was exceeded by the concomitant muscle production (Ra) of these amino acids (57 +/- 5 and 126 +/- 9 nmol/min per dl, respectively), resulting in their net release from the forearm (-14 +/- 4 and -13 +/- 5 nmol/min per dl, respectively). In response to forearm hyperinsulinemia (124 +/- 11 microU/ml), the net balance of phenylalanine and leucine became positive (9 +/- 3 and 61 +/- 8 nmol/min per dl, respectively (P less than 0.005 vs. basal). Despite the marked increase in net balance, the tissue Rd for both phenylalanine (42 +/- 2) and leucine (124 +/- 9) was unchanged from baseline, while Ra was markedly suppressed (to 33 +/- 5 and 63 +/- 9 nmol/min per dl, respectively, P less than 0.01). Since phenylalanine is not metabolized in muscle (i.e., its only fates are incorporation into or release from protein) these results strongly suggest that in normal man, physiologic elevations in insulin promote net muscle protein anabolism primarily by inhibiting protein breakdown, rather than by stimulating protein synthesis.
Analysis of core sequences in the D-Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis

The D-phenylalanine-activating enzyme tyrocidine synthetase I (TycA) from Bacillus brevis ATCC 8185 was overexpressed in Escherichia coli, purified to homogeneity, and assayed for ATP-PPi exchange and covalent binding of phenylalanine by the thiotemplate mechanism. Amino acid exchanges in four different cores of TycA created by site-directed mutagenesis revealed the amino acid residues involved in aminoacyladenylate formation and in covalent thioester formation. Mutations in the putative ATP-binding site SGTTGKPKG caused a decreased phenylalanine-dependent ATP-PPi exchange activity to 10% of the wild-type level for a Lys-186-to-Arg substitution and an almost complete loss of activity (< 1%) for a Lys-186-to-Thr exchange. Alteration of Asp-401 to Asn in the ATPase motif TGDL of TycA decreased the phenylalanine-dependent ATP-PPi exchange activity to 75% of wild type, while an Asp-401-to-Ser mutation decreased the activity to 10% of the wild-type level. Replacement of Ser-562 in the putative thioester-binding motif LGGDSI to Ala or Gly caused a reduction in trichloroacetic acid-precipitable TycA-[14C]phenylalanine complex to one-third of the wild-type level. However, no cleavable [14C]phenylalanine could be detected after treatment with performic acid, indicating that the resulting mutant was unable to form thioester with phenylalanine. In E. coli, TycA was labeled with beta-[3H]alanine, a precursor of 4'-phosphopantetheine, indicating that TycA is modified with a beta-alanine-containing cofactor.
Relationship between anaerobic capacity estimated using a single effort and 30-s tethered running outcomes

The purpose of the current study was to investigate the relationship between alternative anaerobic capacity method (MAODALT) and a 30-s all-out tethered running test. Fourteen male recreational endurance runners underwent a graded exercise test, a supramaximal exhaustive effort and a 30-s all-out test on different days, interspaced by 48h. After verification of data normality (Shapiro-Wilk test), the Pearson’s correlation test was used to verify the association between the anaerobic estimates from the MAODALT and the 30-s all-out tethered running outputs. Absolute MAODALT was correlated with mean power (r = 0.58; P = 0.03), total work (r = 0.57; P = 0.03), and mean force (r = 0.79; P = 0.001). In addition, energy from the glycolytic pathway (E[La-]) was correlated with mean power (r = 0.58; P = 0.03). Significant correlations were also found at each 5s interval between absolute MAODALT and force values (r between 0.75 and 0.84), and between force values and E[La-] (r between 0.73 to 0.80). In conclusion, the associations between absolute MAODALT and the mechanical outputs from the 30-s all-out tethered running test evidenced the importance of the anaerobic capacity for maintaining force during the course of time in short efforts.
Botulinum toxin versus pneumatic dilatation in the treatment of achalasia: a randomised trial

Background Intrasphincteric injection of botulinum toxin is a new treatment option for achalasia. Aims To compare the immediate and long term efficacy of botulinum toxin with that of pneumatic dilatation. Methods Symptomatic patients with achalasia were randomised to botulinum toxin (22 patients, median age 57 years) or pneumatic dilatation (20 patients, median age 56 years). Symptom scores were assessed initially, and at one, three, six, nine, and 12 months after treatment. Objective assessment included oesophageal manometry initially and at one month, and barium oesophagram initially and at one, six, and 12 months post-treatment. Results Pneumatic dilatation resulted in a significantly (p=0.02) higher cumulative remission rate. At 12 months, 14/20 (70%) pneumatic dilatation and 7/22 (32%) botulinum toxin treated patients were in symptomatic remission (p=0.017). Failure rates were similar initially, but failure over time was significantly (p=0.01) higher after botulinum toxin (50%) than pneumatic dilatation (7%). Pneumatic dilatation resulted in significant (p<0.001) reduction in symptom scores, and lower oesophageal sphincter pressure, oesophageal barium column height, and oesophageal diameter. Botulinum toxin produced significant reduction in symptom scores (p<0.001), but no reduction in objective parameters. Conclusions At one year pneumatic dilatation is more effective than botulinum toxin. Symptom improvement parallels objective oesophageal measurements after pneumatic dilatation but not after botulinum toxin treatment for achalasia.
Prescription to 50-75% isodose line may be optimum for linear accelerator based radiosurgery of cranial lesions.

Purpose The prescribed percentage-isodose-line (PIDL) in linac-based SRS varies among institutions. For plans with similar tumor coverage and conformity index, the one with sharper dose falloff outside the tumor volume would be preferred because the probability of brain necrosis is related to the irradiated volume (for example V12Gy) outside the tumor. The aim of this study is to investigate the optimal isodose line that yields the steepest dose falloff for linac-based SRS using dynamic conformal arc technique (DCA). Methods 30 patients with brain tumors were retrospectively studied. The MLC-based DCA was used for planning. For each patient, 5-7 plans with different PIDLs but similar conformity indices were generated. All plans were normalized such that 95% of target volume receives the prescription dose (PD). Gradient index was calculated. The plan with minimum GI was considered optimal. Results Optimal GI decreases (3.9 to 2.2) as target volumes increases (0.15 to 50.1cm3), and the optimal PIDL shifts to higher percentile. Median optimal PIDL is 40.0±7.2% (range 33.2-53.1%) for targets <1cm3 and 62.3±8.3% (range 44.6-72.9%) for those >1cm3. The average planned PIDL used for treatment was 83.6±3.3%. The lower optimal PIDL results in smaller V0.5PD and higher mean dose to the tumor. Conclusion The optimal PIDL appears to be between 50% and 75% which is lower than the commonly used PIDLs in published studies. Larger targets tend to have higher optimal PIDLs. By choosing an optimal PIDL, we could reduce the volume of irradiated normal brain while delivering higher mean dose to the tumor.