Miracle-dz/UniFAR-FTUs huggingface dataset:
Nogo-A Expression After Focal Ischemic Stroke in the Adult Rat

Background and Purpose— The Nogo-A protein is an important inhibitor of axonal remodeling after central nervous system injuries, including ischemic stroke. Interfering with the function of Nogo-A via infusion of a therapeutic anti–Nogo-A antibody after stroke increases neuronal remodeling and enhances functional recovery in rats. In this study, we describe the regional distribution of cortical neurons expressing Nogo-A in normal rats and following middle cerebral artery occlusion (MCAO). Methods— Normal and post-MCAO neuronal Nogo-A expression were described via immunohistochemical analyses. All brains were processed for Nogo-A and parvalbumin expression. The level of Nogo-A expression was scored for each cortical area or white matter structure of interest. The number and fluorescent intensity of layer V neurons in contralesional sensorimotor forelimb cortex were also assessed at each time point. Results— Nogo-A expression was observed in both cortical pyramidal neurons and parvalbumin-positive interneurons. Neuronal expression of Nogo-A changed over time in ipsilesional and contralesional cortical areas after MCAO, becoming globally elevated at 28 days after stroke. Nogo-A expression was not observed to fluctuate greatly in the white matter after stroke, with the exception of a transient increase in Nogo-A expression in the external capsule near the stroke lesion. Conclusions— Neuronal Nogo-A expression is significantly increased at 28 days post-MCAO in all examined brain regions. Because of their robust expression of Nogo-A after stroke lesion, both excitatory and inhibitory neurons represent potential targets for anti–Nogo-A therapies in the poststroke cerebral cortex.
Musical training heightens auditory brainstem function during sensitive periods in development

Experience has a profound influence on how sound is processed in the brain. Yet little is known about how enriched experiences interact with developmental processes to shape neural processing of sound. We examine this question as part of a large cross-sectional study of auditory brainstem development involving more than 700 participants, 213 of whom were classified as musicians. We hypothesized that experience-dependent processes piggyback on developmental processes, resulting in a waxing-and-waning effect of experience that tracks with the undulating developmental baseline. This hypothesis led to the prediction that experience-dependent plasticity would be amplified during periods when developmental changes are underway (i.e., early and later in life) and that the peak in experience-dependent plasticity would coincide with the developmental apex for each subcomponent of the auditory brainstem response (ABR). Consistent with our predictions, we reveal that musicians have heightened response features at distinctive times in the life span that coincide with periods of developmental change. The effect of musicianship is also quite specific: we find that only select components of auditory brainstem activity are affected, with musicians having heightened function for onset latency, high-frequency phase-locking, and response consistency, and with little effect observed for other measures, including lower-frequency phase-locking and non-stimulus-related activity. By showing that musicianship imparts a neural signature that is especially evident during childhood and old age, our findings reinforce the idea that the nervous system's response to sound is “chiseled” by how a person interacts with his specific auditory environment, with the effect of the environment wielding its greatest influence during certain privileged windows of development.
The structure of innate vocalizations in Foxp2-deficient mouse pups

Heterozygous mutations of the human FOXP2 gene are implicated in a severe speech and language disorder. Aetiological mutations of murine Foxp2 yield abnormal synaptic plasticity and impaired motor‐skill learning in mutant mice, while knockdown of the avian orthologue in songbirds interferes with auditory‐guided vocal learning. Here, we investigate influences of two distinct Foxp2 point mutations on vocalizations of 4‐day‐old mouse pups (Mus musculus). The R552H missense mutation is identical to that causing speech and language deficits in a large well‐studied human family, while the S321X nonsense mutation represents a null allele that does not produce Foxp2 protein. We ask whether vocalizations, based solely on innate mechanisms of production, are affected by these alternative Foxp2 mutations. Sound recordings were taken in two different situations: isolation and distress, eliciting a range of call types, including broadband vocalizations of varying noise content, ultrasonic whistles and clicks. Sound production rates and several acoustic parameters showed that, despite absence of functional Foxp2, homozygous mutants could vocalize all types of sounds in a normal temporal pattern, but only at comparably low intensities. We suggest that altered vocal output of these homozygotes may be secondary to developmental delays and somatic weakness. Heterozygous mutants did not differ from wild‐types in any of the measures that we studied (R552H ) or in only a few (S321X ), which were in the range of differences routinely observed for different mouse strains. Thus, Foxp2 is not essential for the innate production of emotional vocalizations with largely normal acoustic properties by mouse pups.
Atmospheric Chemistry and Physics a Novel Model to Predict the Physical State of Atmospheric H 2 so 4 /nh 3 /h 2 O Aerosol Particles

The physical state of the tropospheric aerosol is largely unknown despite its importance for cloud formation and for the aerosol's radiative properties. Here we use detailed microphysical laboratory measurements to perform a systematic global modelling study of the physical state of the H 2 SO 4 /NH 3 /H 2 O aerosol, which constitutes an important class of aerosols in the free troposphere. The Aerosol Physical State Model (APSM) developed here is based on Lagrangian trajectories computed from ECMWF (European Centre for Medium Range Weather Forecasts) analyses, taking full account of the deliquescence/efflorescence hystere-sis. As input APSM requires three data sets: (i) deliques-cence and efflorescence relative humidities from laboratory measurements, (ii) ammonia-to-sulfate ratios (ASR) calculated by a global circulation model, and (iii) relative hu-midities determined from the ECMWF analyses. APSM results indicate that globally averaged a significant fraction (17–57%) of the ammoniated sulfate aerosol particles contain solids with the ratio of solid-containing to purely liquid particles increasing with altitude (between 2 and 10 km). In our calculations the most abundant solid is letovicite, (NH 4) 3 H(SO 4) 2 , while there is only little ammonium sul-fate, (NH 4) 2 SO 4. Since ammonium bisulfate, NH 4 HSO 4 , does not nucleate homogeneously, it can only form via heterogeneous crystallization. As the ammonia-to-sulfate ratios of the atmospheric H 2 SO 4 /NH 3 /H 2 O aerosol usually do not correspond to the stoichiometries of known crystalline substances, all solids are expected to occur in mixed-phase aerosol particles. This work highlights the potential importance of letovicite, whose role as cloud condensation nucleus (CCN) and as scatterer of solar radiation remains to be scrutinized .
Survival benefits of gastrectomy in gastric cancer patients with stage IV: a population-based study

Objective The aim of the current study is to investigate the role of gastrectomy for survival among metastatic gastric cancer patients. Results We finally identified 12,986 eligible patients with stage IV GC between 2004 and 2012, including 1,981 (15.3%) patients with gastrectomy and 11,005 (84.7%) without surgery. The median overall survival time for patients with and without surgery were 9.0 (95%, 8.3–9.7) and 4.0 (95%, 3.9–4.1) months respectively. Patients who received gastrectomy had a significantly better survival outcome compared with those without surgery (P < 0.05). In the multivariate Cox analysis, gastrectomy was associated with decreased overall mortality (HR, 0.47, 95% CI 0.44–0.49, P < 0.001) and cancer-specific mortality (HR, 0.46, 95% CI 0.44–0.50, P < 0.001). The survival benefits associated with surgery persisted even after performing the propensity score matching analysis (overall survival, HR, 0.47, 95% CI 0.43–0.50, cancer-specific survival, HR, 0.47, 95% CI 0.44–0.50). Conclusions Based on population-based study, we demonstrated that there was a survival advantage of gastrectomy in stage IV GC patients. Further prospective trials need to verify our findings. Materials and Methods We included an eligible cohort of stage IV gastric cancer (GC) patients in the Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2012. The survival difference of patients with and without gastrectomy were assessed by Kaplan–Meier analysis and log-rank test. Multivariate Cox analyses were performed to analyze the effect of gastrectomy on overall and cancer-specific mortality. Furthermore, we performed propensity score matching (PSM) to reduce the potential selection bias.
Blind Adaptive Constrained Reduced-Rank Parameter Estimation Based on Constant Modulus Design for CDMA Interference Suppression

This paper proposes a multistage decomposition for blind adaptive parameter estimation in the Krylov subspace with the code-constrained constant modulus (CCM) design criterion. Based on constrained optimization of the constant modulus cost function and utilizing the Lanczos algorithm and Arnoldi-like iterations, a multistage decomposition is developed for blind parameter estimation. A family of computationally efficient blind adaptive reduced-rank stochastic gradient (SG) and recursive least squares (RLS) type algorithms along with an automatic rank selection procedure are also devised and evaluated against existing methods. An analysis of the convergence properties of the method is carried out and convergence conditions for the reduced-rank adaptive algorithms are established. Simulation results consider the application of the proposed techniques to the suppression of multiaccess and intersymbol interference in DS-CDMA systems.
A Neural Knowledge Language Model

Current language models have significant limitations in their ability to encode and decode knowledge. This is mainly because they acquire knowledge based on statistical co-occurrences, even if most of the knowledge words are rarely observed named entities. In this paper, we propose a Neural Knowledge Language Model (NKLM) which combines symbolic knowledge provided by a knowledge graph with the RNN language model. At each time step, the model predicts a fact on which the observed word is to be based. Then, a word is either generated from the vocabulary or copied from the knowledge graph. We train and test the model on a new dataset, WikiFacts. In experiments, we show that the NKLM significantly improves the perplexity while generating a much smaller number of unknown words. In addition, we demonstrate that the sampled descriptions include named entities which were used to be the unknown words in RNN language models.
Infinite matrix representations of robust stability conditions for discrete-time systems

This paper is motivated by the study on clarifying further relationship between the conventional lifting-free scaling and lifting-based noncausal linear periodically time-varying scaling approaches to robust stability analysis. To facilitate such a study, this paper gives the infinite matrix representation counterparts of the robust stability conditions in the separator-type robust stability theorems for these approaches. These counterparts lead to the idea of infinite-dimensional separators, and provide us with a unified framework for studying the mutual relationship between these two approaches. Through the derivation and comparison of explicit forms of infinite-dimensional separators in these two approaches, it is demonstrated that the infinite matrix representation framework leads to a very comprehensible and intuitive study on the mutual relationship between these approaches.
Negotiated Shareholder Value: The German Variant of an Anglo-American Practice

In comparative political economy it has become commonplace to distinguish between two types of corporate governance systems. In shareholder systems, influence over company management is concentrated with institutional investors holding small percentages of companies' shares. In stakeholder systems, influence is shared between large shareholders, employees, the community and suppliers and customers. This paper contributes to the literature addressing recent changes in the German variant of the stakeholder system by proposing a few new concepts. On the level of institutions, it is argued that the stakeholder system is not being replaced by a shareholder system in Germany. Rather, an augmented stakeholder system is emerging through the inclusion of institutional investors in the old stakeholder coalition of interests. On the level of practice, it is argued that negotiated shareholder value is being adopted in Germany. This German variant of shareholder value is distinct from Anglo-American practice because major changes implementing shareholder value must be negotiated within the augmented stakeholder coalition. As a result, performance incentives for employees tend to be less strong than is the case in the USA and UK.
Comparison of 2 family therapies for adolescent anorexia nervosa: a randomized parallel trial.

IMPORTANCE Anorexia nervosa (AN) is a serious disorder with high rates of morbidity and mortality. Family-based treatment (FBT) is an evidence-based therapy for adolescent AN, but less than half of those who receive this approach recover. Hence, it is important to identify other approaches to prevent the development of the chronic form of AN for which there is no known evidence-based treatment. OBJECTIVE To compare FBT with systemic family therapy (SyFT) for the treatment of adolescent-onset AN. DESIGN, SETTING, AND PARTICIPANTS Research in Anorexia Nervosa (RIAN) is a 2-group (FBT and SyFT) randomized trial conducted between September 2005 and April 2012. Interviewers were blinded to the treatment condition. A total of 564 adolescents receiving care at 6 outpatient clinics experienced in the treatment of AN were screened. Of these, 262 adolescents did not meet the inclusion criteria and 138 declined to participate; hence, 164 adolescents (aged 12-18 years) of both sexes meeting the criteria for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, AN (except for amenorrhea) were enrolled. Three participants were withdrawn from FBT and 7 were withdrawn from SyFT after serious adverse events occurred. INTERVENTIONS Two manualized family therapies with 16 one-hour sessions during 9 months. Family-based therapy focuses on the facilitation of weight gain, whereas SyFT addresses general family processes. MAIN OUTCOMES AND MEASURES The primary outcomes were percentage of ideal body weight (IBW) and remission (≥95% of IBW). The a priori hypothesis was that FBT would result in faster weight gain early in treatment and at the end of treatment (EOT). RESULTS There were no statistically significant differences between treatment groups for the primary outcome, for eating disorder symptoms or comorbid psychiatric disorders at the EOT or follow-up. Remission rates included FBT, 33.1% at the EOT and 40.7% at follow-up and SyFT, 25.3% and 39.0%, respectively. Family-based therapy led to significantly faster weight gain early in treatment, significantly fewer days in the hospital, and lower treatment costs per patient in remission at the EOT (FBT, $8963; SyFT, $18 005). An exploratory moderator analysis found that SyFT led to greater weight gain than did FBT for participants with more severe obsessive-compulsive symptoms. CONCLUSIONS AND RELEVANCE The findings of this study suggest that FBT is the preferred treatment for adolescent AN because it is not significantly different from SyFT and leads to similar outcomes at a lower cost than SyFT. Adolescents with more severe obsessive-compulsive symptoms may receive more benefits with SyFT. TRIAL REGISTRATION clinicaltrials.gov Identifier NCT00610753.
Single‐Crystal Boundary Migration in Hot‐Pressed Aluminum Oxide

The growth of sapphire filaments embedded in hot-pressed alumina was studied at 1672°C. In undoped alumina, a constant growth rate of 1.17×10-6 cm/s was observed. The initial growth rate into MgO-doped alumina was 4.6×10-8 cm/s, decreasing with increasing matrix grain size. Observed rates of boundary migration were larger than those of previously reported data.
A Brascamp-Lieb-Luttinger–type inequality and applications to symmetric stable processes

We derive an inequality for multiple integrals from which we conclude various generalized isoperimetric inequalities for Brownian motion and symmetric stable processes in convex domains of fixed inradius. Our multiple integral inequality is a replacement for the classical inequality of H. J. Brascamp, E. H. Lieb and J. M. Luttinger, where instead of fixing the volume of the domain one fixes its inradius.
Regular Multigraphs of High Degree are 1‐Factorizable

Chetwynd and Hilton showed that any regular simple graph with even order n and maximum degree at least \n has chromatic index equal to its maximum degree. We show how to extend this result to general multigraphs, including those of odd order. This also verifies a special case of conjectures by Goldberg and Seymour.
The Comparison of the Efficacy of Blue Light-Emitting Diode Light and 980-nm Low-Level Laser Light on Bone Regeneration

AbstractThe aim of this study is to histologically compare effects of blue light-emitting diode (LED) light (400–490 nm) and Ga–Al–As low-level diode laser light (980 nm) on bone regeneration of calvarial critical-sized defects in rats. Thirty Wistar Albino rats were included in the study. The experimental groups were as follows: blue LED light (400–490 nm) group (LED); 980-nm low-level laser light group (LL); and no-treatment, control group (CL). A critical-sized defect of 8 mm was formed on calvaria of rats. Each animal was sacrificed 21 days after defect formation. Calvarias of all rats were dissected and fixated for histological examination. Histomorphometric measurements of total horizontal length of the newly produced bone tissue, total vertical length of the newly produced bone tissue, and diameter of the newly produced longest bone trabecula were performed with a computer program in micrometers. There was a statistically significant increase in the total horizontal length and total vertical length in LL and LED groups compared to that in the CL group (P < 0.05), while there was no statistical difference between LED and LL groups (P > 0.05). A statistically significant difference was observed in the longest bone trabecula and LL groups compared to that in CL (P < 0.05), but not between LED–CL and LED–LL groups (P > 0.05). In conclusion, blue LED light significantly enhances bone regeneration in critical-sized defects when compared with CL group, but does not have a statistically significant effect on bone regeneration when compared with 980-nm low-level laser light.
Market Timing and Capital Structure

It is well known that firms are more likely to issue equity when their market values are high, relative to book and past market values, and to repurchase equity when their market values are low. We document that the resulting effects on capital structure are very persistent. As a consequence, current capital structure is strongly related to past market values. The results suggest the theory that capital structure is the cumulative outcome of past attempts to time the equity market.
A multiscale computational model of spatially resolved calcium cycling in cardiac myocytes: from detailed cleft dynamics to the whole cell concentration profiles

Mathematical modeling of excitation-contraction coupling (ECC) in ventricular cardiac myocytes is a multiscale problem, and it is therefore difficult to develop spatially detailed simulation tools. ECC involves gradients on the length scale of 100 nm in dyadic spaces and concentration profiles along the 100 μm of the whole cell, as well as the sub-millisecond time scale of local concentration changes and the change of lumenal Ca2+ content within tens of seconds. Our concept for a multiscale mathematical model of Ca2+ -induced Ca2+ release (CICR) and whole cardiomyocyte electrophysiology incorporates stochastic simulation of individual LC- and RyR-channels, spatially detailed concentration dynamics in dyadic clefts, rabbit membrane potential dynamics, and a system of partial differential equations for myoplasmic and lumenal free Ca2+ and Ca2+-binding molecules in the bulk of the cell. We developed a novel computational approach to resolve the concentration gradients from dyadic space to cell level by using a quasistatic approximation within the dyad and finite element methods for integrating the partial differential equations. We show whole cell Ca2+-concentration profiles using three previously published RyR-channel Markov schemes.
A Mathematical Model for Solute Redistribution during Dendritic Solidification

To quantify the solute redistribution during solidification, an approximate solution of the Brody-Flemings model of dendritic solidification has been derived on the assumption of parabolic solidification and a constant partition ratio, and compared with an exact solution of the model. It has been shown that the approximate solution has good accuracy. Further, on the basis of the derived equation, an extended mathematical model is proposed, incorporating a thermal model of solidification into the analysis without assumption on the solidification rate. The extended model includes the treatment of multi-component alloy and δ/γ transformation, the temperature dependence of diffusion coefficients and the estimation of the diffusion path. The extended model provides the results consistent with the available data.
Peritumoral diffusion tensor imaging of high-grade gliomas and metastatic brain tumors.

BACKGROUND AND PURPOSE Diffusion tensor imaging (DTI) is an advanced MR technique that describes the movement of water molecules by using two metrics, mean diffusivity (MD), and fractional anisotropy (FA), which represent the magnitude and directionality of water diffusion, respectively. We hypothesize that alterations in these values within the tissue surrounding brain tumors reflect combinations of increased water content and tumor infiltration and that these changes can be used to differentiate high-grade gliomas from metastatic lesions. METHODS DTI was performed in 12 patients with high-grade gliomas and in 12 with metastatic lesions. DTI measurements were obtained from regions of interest (ROIs) placed on normal-appearing white matter and on the vasogenic edema, the T2 signal intensity abnormality surrounding each tumor. RESULTS The peritumoral region of both gliomas and metastatic tumors displayed significant increases in MD (P <.005) and significant decreases in FA (P <.005) when compared with those of normal-appearing white matter. Furthermore, the peritumoral MD of metastatic lesions measured significantly greater than that of gliomas (P <.005). Peritumoral FA measurements, on the other hand, showed no such discrepancy. CONCLUSION When compared with an internal control, diffusion metrics are clearly altered within the vasogenic edema surrounding both high-grade gliomas and metastatic tumors, reflecting increased extracellular water. Although peritumoral MD can be used to distinguish high-grade gliomas from metastatic tumors, peritumoral FA demonstrated no statistically significant difference. The FA changes surrounding gliomas, therefore, can be attributed not only to increased water content, but also to tumor infiltration.