Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of differential item functioning on age and gender differences in functional disability.

OBJECTIVES Estimates of group differences in functional disability may be biased if items exhibit differential item functioning (DIF). For a given item, DIF exists if persons in different groups do not have the same probability of responding, given their level of disability. This study examines the extent to which DIF affects estimates of age and gender group differences in disability severity among adults with some functional disability. METHODS Data came from the 1994/1995 National Health Interview Survey Disability Supplement. Analyses focused on 5,750 adult respondents who received help or supervision with at least one of 11 activities of daily living/instrumental activities of daily living tasks. We estimated gender and age group (18-39, 40-69, and 70+) differences in disability, using multiple-indicator/multiple-cause models, which treat functional disability as a latent trait. RESULTS Nine items manifested significant DIF by age or gender; DIF was especially large for "shopping" and "money management. " Without adjusting for DIF, middle-aged persons were less disabled than elderly men, and women were less disabled than men among nonelderly persons. After adjusting for DIF, middle-aged persons did not differ from elderly persons, and gender differences within age groups were not significant. DISCUSSION Comparisons of disability across sociodemographic groups need to take DIF into account. Future research should examine the causes of DIF and develop alternative question wordings that reduce DIF effects.
Modulation of electronic properties of tin oxide nanobelts via thermal control of surface oxygen defects

Nanomaterials made from binary metal oxides are of increasing interest because of their versatility in applications from flexible electronics to portable chemical and biological sensors. Controlling the electrical properties of these materials is the first step in device implementation. Tin dioxide (SnO2) nanobelts (NB) synthesized by the vapor–liquid–solid mechanism have shown much promise in this regard. We explore the modification of devices prepared with single crystalline NBs by thermal annealing in vacuum and oxygen, resulting in a viable field-effect transistor (FET) for numerous applications at ambient temperature. An oxygen annealing step initially increases the device conductance by up to a factor of 105, likely through the modification of the surface defects of the NB, leading to Schottky barrier limited devices. A multi-step annealing procedure leads to further increase of the conductance by approximately 350% and optimization of the electronic properties. The effects of each step is investigated systematically on a single NB. The optimization of the electrical properties of the NBs makes possible the consistent production of channel-limited FETs and control of the device performance. Understanding these improvements on the electrical properties over the as-grown materials provides a pathway to enhance and tailor the functionalities of tin oxide nanostructures for a wide variety of optical, electronic, optoelectronic, and sensing applications that operate at room temperature.
Basic Concepts of Optical Mapping Techniques in Cardiac Electrophysiology

Optical mapping is a tool used in cardiac electrophysiology to study the heart’s normal rhythm and arrhythmias. The optical mapping technique provides a unique opportunity to obtain membrane potential recordings with a higher temporal and spatial resolution than electrical mapping. Additionally, it allows simultaneous recording of membrane potential and calcium transients in the whole heart. This article presents the basic concepts of optical mapping techniques as an introduction for students and investigators in experimental laboratories unfamiliar with it.
Coronary Heart Disease in Women: A Challenge for the 21st Century

Heart disease is the first killer of women in the modern era, regardless of age, race and of ethnicity, although its prevalence rises after menopause. Modern women have professional and housewife responsibilities, consume excess of fat and carbohydrates, smoke, do not exercise regularly and do not have enough time to rest. This situation leads to overweight, dyslipidemia, arterial hypertension, impaired glucose tolerance and diabetes. Women do not often participate in preventive studies and still undergo less intensive and invasive evaluation and treatment for chest pain when compared to men. However, the rate of coronary death is twice higher in women than in men after myocardial infarction and revascularization procedures. The objective of this review is to analyze the main gender differences regarding symptoms, diagnosis, management and prognosis of coronary heart disease and to discuss the influence of hormonal replacement therapy in the prevention of cardiovascular disease in postmenopausal women.
The petrogenesis of type B1 Ca‐Al‐rich inclusions: The spinel perspective

Abstract— Minor element variations in MgAl2O4 spinel from the type B1 calcium‐aluminum‐rich inclusion (CAI) Allende TS‐34 confirm earlier studies in showing correlations between the minor element chemistry of spinels with their location within the inclusion and with the chemistry of host silicate phases. These correlations result from a combination of crystallization of a liquid produced by re‐melting event(s) and local re‐equilibration during subsolidus reheating. The correlation of the Ti and V in spinel inclusions with the Ti and V in the adjacent host clinopyroxene can be qualitatively explained by spinel and clinopyroxene crystallization prior to melilite, following a partial melting event. There are, however, difficulties in quantitative modeling of the observed trends, and it is easier to explain the Ti correlation in terms of complete re‐equilibration. The correlation of V in spinel inclusions with that in the adjacent host clinopyroxene also cannot be quantitatively modeled by fractional crystallization of the liquid produced by re‐melting, but it can be explained by partial re‐equilibration. The distinct V and Ti concentrations in spinel inclusions in melilite from the edge regions of the CAI are best explained as being affected by only a minor degree of re‐equilibration. The center melilites and included spinels formed during crystallization of the liquid produced by re‐melting, while the edge melilites and included spinels are primary. The oxygen isotope compositions of TS‐34 spinels are uniformly 16O‐rich, regardless of the host silicate phase or its location within the inclusion. Similar to other type B1 CAIs, clinopyroxene is 16O‐rich, but melilite is relatively 16O‐poor. These data require that the oxygen isotope exchange in TS‐34 melilite occurred subsequent to the last re‐melting event.
Peripheral extracorporeal membrane oxygenation system as salvage treatment of patients with refractory cardiogenic shock: preliminary outcome evaluation.

The novel Permanent Life Support (PLS; Maquet, Jostra Medizintechnik AG, Hirrlingen, Germany) as peripheral veno-arterial extracorporeal membrane oxygenation (ECMO) support system has been investigated as treatment for patients with refractory cardiogenic shock (CS). Between January 2007 and July 2011, 73 consecutive adult patients were supported on peripheral PLS ECMO system at our institution (55 men; age 60.3 ± 11.6 years, range: 23-84 years). Indications for support were failure to wean from cardiopulmonary bypass in the setting of postcardiotomy (n = 50) and primary donor graft failure (n = 8), post-acute myocardial infarction CS (n = 12), and CS on chronic heart failure (n = 3). Mean support time was 10.9 ± 7.6 days (range: 2-34 days). Overall, 26 (35.6%) patients died on ECMO. Among survivors on ECMO, 44 (60.2%) patients were successfully weaned from support, and three (4.1%) were switched to a mid-long-term ventricular assist device. Thirty-three (45.2%) were successfully discharged. The following variables were significantly different if survivors and nonsurvivors on ECMO were compared: age (P = 0.04), female gender (P < 0.01), cardiopulmonary resuscitation before ECMO (P < 0.01), lactate level before ECMO (P = 0.01), number of platelets, fresh frozen plasma units, and packed red blood cells (PRBCs) transfused during ECMO support (P = 0.03, P = 0.02, and P < 0.01), blood lactate level (P = 0.01), and creatine kinase isoenzyme MB (CK-MB) relative index 72 h after ECMO initiation (P < 0.001), and multiple organ failure on ECMO (P < 0.01). Stepwise logistic regression identified blood lactate level and CK-MB relative index at 72 h after ECMO initiation, and number of PRBCs transfused on ECMO as significant predictors of mortality on ECMO (P = 0.011, odds ratio [OR] = 2.48; 95% confidence interval [CI] = 1.11-3.12; P = 0.012, OR = 2.81, 95% CI = 1.026-2.531; and P = 0.012, OR = 1.94, 95% CI = 1.02-5.21; respectively). Patients with an initial poor hemodynamic status could benefit by rapid peripheral installation of PLS ECMO. The blood lactate level, CK-MB relative index, and PRBCs transfused should be strictly monitored during ECMO support.
The Feasibility, Acceptability, and Efficacy of Delivering Internet-Based Self-Help and Guided Self-Help Interventions for Generalized Anxiety Disorder to Indian University Students: Design of a Randomized Controlled Trial

Background Generalized anxiety disorder (GAD) is one of the most common mental disorders among university students; however, many students go untreated due to treatment costs, stigma concerns, and limited access to trained mental health professionals. These barriers are heightened in universities in India, where there are scant mental health care services and severe stigma surrounding help seeking. Objective To evaluate the feasibility, acceptability, and efficacy of Internet-based, or “online,” cognitive behavioral therapy (CBT)-based unguided and guided self-help interventions (using the programs GAD Online and Lantern, respectively) to reduce GAD symptoms in students with clinical and subthreshold GAD and, ultimately, reduce the prevalence and incidence of GAD among the student population. Methods Students will be recruited via 3 colleges in Hyderabad, India, and referred for a campus-wide online screening. Self-report data will be collected entirely online. A total of 300 qualifying students will be randomized in a 1:1:1 ratio to receive GAD Online, Lantern, or to be in a wait-list control condition, stratified by clinical and subthreshold GAD symptomatology. Students will complete a postintervention assessment after 3 months and a follow-up assessment 6 months later, at which point students in the wait-list control condition will receive one of the programs. The primary outcome is GAD symptom severity at 3 months postintervention. Secondary outcomes include GAD caseness at 9 months, other anxiety and depression symptoms, self-efficacy, and functional measures (eg, sleep, social functioning) at 3 and 9 months, respectively. Primary analyses will be differences between each of the intervention groups and the wait-list control group, analyzed on an intention-to-treat (ITT) basis using mixed-design ANOVA. Results The study commenced in February 2015. The sample was recruited over a 3-week period at each college. The trial is expected to end in December 2015. Conclusions This trial will be the first to evaluate the use of Internet-based CBT programs compared with a wait-list control group for the treatment of GAD among students in Indian universities. If effective, these programs have the potential to reduce the mental health care treatment gap by providing readily accessible, private, and cost-effective evidence-based care to students with GAD who do not currently receive the treatment they need. Trial Registration ClinicalTrials.gov NCT02410265 http://clinicaltrials.gov/ct2/show/NCT02410265 (Archived by WebCite at http://www.webcitation.org/6ddqH6Rbt).
Resident Training in Developmental/Behavioral Pediatrics: Where Do We Stand?

Approximately 25% to 30% of all complaints to a general pediatrician are developmental or behavioral in origin. Despite this, residency education in developmental/behavioral pediatrics has consistently been rated poorly. Changes were set forth in 1997 to include a mandatory 1-month block rotation in developmental/behavioral pediatrics. This study was a nationwide, cross-sectional, self-administered, mailed survey of pediatricians who completed residency either before or after these changes went into effect. Overall, pediatricians’ comfort level in developmental/behavioral pediatrics was unchanged in the 2 groups. Certain areas (behavior problems, learning disabilities, sleep, and depression/anxiety) of developmental/behavioral pediatrics had lower comfort scores. Our data provide direction for the ongoing refinement of pediatric education that is based on feedback from currently practicing pediatricians.
Identifying clusters of functionally related genes in genomes

MOTIVATION An increasing body of literature shows that genomes of eukaryotes can contain clusters of functionally related genes. Most approaches to identify gene clusters utilize microarray data or metabolic pathway databases to find groups of genes on chromosomes that are linked by common attributes. A generalized method that can find gene clusters regardless of the mechanism of origin would provide researchers with an unbiased method for finding clusters and studying the evolutionary forces that give rise to them. RESULTS We present an algorithm to identify gene clusters in eukaryotic genomes that utilizes functional categories defined in graph-based vocabularies such as the Gene Ontology (GO). Clusters identified in this manner need only have a common function and are not constrained by gene expression or other properties. We tested the algorithm by analyzing genomes of a representative set of species. We identified species-specific variation in percentage of clustered genes as well as in properties of gene clusters including size distribution and functional annotation. These properties may be diagnostic of the evolutionary forces that lead to the formation of gene clusters. AVAILABILITY A software implementation of the algorithm and example output files are available at http://fcg.tamu. edu/C_Hunter/.
An 60 W average power wideband amplifier with envelope tracking for DVB-T applications

In this paper, the development of a DVB-T power amplifier (PA) with enhanced efficiency performance based on the envelope tracking method (ET) is described. The amplifier works in the ultrahigh frequency (UHF) band from 470 to 803 MHz. The PA consists of two coupled push-pull stages of laterally diffused metal oxide semiconductors (LDMOS) that are combined and equipped with a multilevel Supply Modulator to achieve a drain modulation. The results indicate an improved drain efficiency within 14.6 % up to η ≥ 42 % for a 8 MHz coded orthogonal frequency division multiplexing (COFDM) — signal with 9 dB peak-to-average power ratio (PAPR) including the losses of the Supply Modulator. While fulfilling the spectrum mask, the output power is higher than 60 W (470 W peak) for the frequency range from 470–803 MHz.
PRINT MEDIA COVERAGE OF SAME SEX MARRIAGE LAW IN NIGERIA: A CONTENT ANALYSIS OF SUN, THISDAY, GUARDIAN AND VANGUARD NEWSPAPERS

This study dwelt on Print Media Coverage of Same Sex Marriage law in Nigeria. It was aimed at ascertaining the degree of Coverage given to the same sex marriage law passed in 2014 with emphasis on ascertaining the frequency of coverage of the law, placement of the stories in the newspapers, dominant story type used in reporting the stories, and framing of the stories. Purposive sampling technique was adopted in the selection of sample size of 189 out of 360 newspaper published within the period of study. Dailysun, Thisday, Guardian and Vanguard Newspapers were selected and studied for a period of three months from among the 34 registered Nigerian Newspapers in circulation. Findings show that Nigerian dailies gave high volume of coverage to same sex marriage law within the period of study and framed the stories in favour of passage of the bill into law. The research therefore recommends that Nigerian newspapers should strive to adhere to objectivity in the reportage of issues in the society no matter their cultural connotations of such issues.
Diagnosis of Human Visceral Pentastomiasis

Visceral pentastomiasis in humans is caused by the larval stages (nymphs) of the arthropod-related tongue worms Linguatula serrata, Armillifer armillatus, A. moniliformis, A. grandis, and Porocephalus crotali. The majority of cases has been reported from Africa, Malaysia, and the Middle East, where visceral pentastomiasis may be an incidental finding in autopsies, and less often from China and Latin America. In Europe and North America, the disease is only rarely encountered in immigrants and long-term travelers, and the parasitic lesions may be confused with malignancies, leading to a delay in the correct diagnosis. Since clinical symptoms are variable and serological tests are not readily available, the diagnosis often relies on histopathological examinations. This laboratory symposium focuses on the diagnosis of this unusual parasitic disease and presents its risk factors and epidemiology.
Evaluation of gravid traps for the collection of Culex quinquefasciatus, a vector of lymphatic filariasis in Tanzania.

BACKGROUND Although several studies have suggested that gravid traps might be useful for collection of mosquitoes, particularly Culex quinquefasciatus, to monitor transmission of the nematode Wuchereria bancrofti (xenomonitoring), there has not been a study to see which of the currently available gravid traps is most effective in endemic areas. The present study evaluated the comparative efficacy for collection of Cx quinquefasciatus of four commercially available gravid traps: the CDC, Frommer Updraft, Reiter-Cummings and Harris County traps. METHOD Trap evaluations were conducted in two locations in Tanzania, Ifakara and Tanga. Mosquitoes collected were identified to species, sex, and gonotrophic status. RESULTS In both locations, the CDC gravid trap collected the highest number of mosquitoes, the highest number of Cx quinquefasciatus, and the highest proportion of gravid mosquitoes. Although it damaged the highest proportion of mosquitoes as they passed through the trap fan, the CDC gravid trap also contained the highest number of living mosquitoes, when the traps were collected in the morning. The CDC gravid traps collected significantly more phlebotomine sandflies than the other traps and in Tanga, where they were more frequent, the highest number of biting midges. CONCLUSION The effectiveness of all four gravid traps should encourage the sampling of Cx quinquefasciatus where it is an important disease vector or nuisance mosquito. The unexpected collection of phlebotomine sandflies and biting midges indicates that gravid traps might usefully collect other insects, including those of medical importance.
Violent Video Games and Aggression

Two studies examined the relationship between exposure to violent video games and aggression or violence in the laboratory and in real life. Study 1 participants were either randomized or allowed to choose to play a violent or nonviolent game. Although males were more aggressive than females, neither randomized exposure to violent-video-game conditions nor previous real-life exposure to violent video games caused any differences in aggression. Study 2 examined correlations between trait aggression, violent criminal acts, and exposure to both violent games and family violence. Results indicated that trait aggression, family violence, and male gender were predictive of violent crime, but exposure to violent games was not. Structural equation modeling suggested that family violence and innate aggression as predictors of violent crime were a better fit to the data than was exposure to video game violence. These results question the common belief that violent-video-game exposure causes violent acts.
Mesenchymal Stromal Cells and Toll-Like Receptor Priming: A Critical Review

Mesenchymal Stromal Cells (MSCs) are potential cellular candidates for several immunotherapy purposes. Their multilineage potential and immunomodulatory properties make them interesting tools for the treatment of various immunological diseases. However, depending on the local microenvironment, diverse biological functions of MSCs can be modulated. Indeed, during infections such as obtained following TLR-agonist engagement (called as TLR priming), the phenotype, multilineage potential, hematopoietic support and immunomodulatory capacity of MSCs can present critical changes, which could further affect their therapeutic potential. Thus, for appropriate clinical application of MSCs, it is important to well know and understand these effects in particular during infectious episodes and to find the suitable experimental settings to study that. Pre-stimulation of MSCs with a specific TLR ligand may serve as an effective priming step to modulate one of its function to achieve a desired therapeutic issue.
Simultaneous feature selection and classification for relevance feedback in image retrieval

In image retrieval, relevance feedback uses information, obtained interactively from the user, to understand the user's perceptions of a query image and to improve retrieval accuracy. We propose simultaneous relevant feature selection and classification using the samples provided by the user to improve retrieval accuracy. The classifier is defined by a separating hyperplane, while the sparse weight vector characterizing the hyperplane defines a small set of relevant features. This set of relevant features is used for classification and can be used for analysis at a later stage. Mutually exclusive sets of images are shown to the user at each iteration to obtain maximum information from the user. Experimental results show that our algorithm performs better than the feature relevance weighting and feature selection schemes and comparably with the classification scheme using SVMs, in terms of retrieval accuracy, and it has the advantage of being faster than the classification scheme using SVMs.
Immunotherapy with Imiquimod increases the efficacy of Glucantime therapy of Leishmania major infection.

BACKGROUND Leishmaniasis is a complex disease which presents as visceral, cutaneous and mucocutaneous forms. The current treatment options for this infection are very limited and the immunological state of the host appears to play an important role in the efficacy of the treatment. Immunostimulation through immune response activating agents such as Imiquimod is another rational approach for this purpose. OBJECTIVE We assessed the efficacy of immunotherapy with Imiquimod alone or combined with Glucantime for treatment of Leishmania major infection in BALB/c mice. METHODS Treatment efficacy was monitored by determination of thickness and parasite load of infected footpad of mice. RESULTS The footpad thickness revealed that treatment with Imiquimod plus Glucantime has the highest efficacy. The results were confirmed by parasite load of infected footpad. Our data shows that treatment of Leishmania major infection in BALB/c mice by the combined Imiquimod and Glucantime is more efficient than each drug alone. CONCLUSION The combination of Imiquimod with chemotherapy may offer a way for more efficient treatment of leishmaniasis.