Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of skin tumor promoter-caused induction of epidermal ornithine decarboxylase in SENCAR mice by polyphenolic fraction isolated from green tea and its individual epicatechin derivatives.

Green tea, next to water, is the most popular and commonly consumed beverage in the world, especially in eastern countries. In prior studies we have shown that the polyphenolic fraction isolated from green tea (GTP) exerts antigenotoxic effects in various mutagenicity test systems (Mutat. Res., 223: 273-285, 1989) and that its topical application or oral feeding in drinking water protects against polycyclic aromatic hydrocarbon-induced skin tumor initiation and complete carcinogenesis in SENCAR and BALB/c mice [Cancer Lett. , 42: 7-12, 1988; Carcinogenesis (Lond.), 10: 411-415, 1989] and UV B radiation-induced photocarcinogenesis in SKH-1 hairless mice [Carcinogenesis (Lond.), 12: 1527-1530, 1991]. In the present study we assessed the effect of skin application of GTP to SENCAR mice on 12-O-tetradecanoylphorbol-13-acetate (TPA) and other skin tumor promoter-caused induction of epidermal ornithine decarboxylase (ODC) activity. Topical application of GTP to mouse skin inhibited TPA-induced epidermal ODC activity in a dose-dependent manner. The inhibitory effect of GTP was also dependent on the time of its application relative to TPA treatment. Maximum inhibitory effect was observed when GTP was applied 30 min prior to topical application of TPA. GTP application to animals also inhibited the induction of epidermal ODC activity caused by several structurally different mouse skin tumor promoters. In order to identify which of the specific epicatechin derivatives present in GTP is responsible for these inhibitory effects, they were isolated from GTP and evaluated for their inhibitory effects against TPA-caused induction of epidermal ODC activity. Among these, (-)epigallocatechin-3-gallate (EGCG), which was the major constituent present in GTP by weight, exerted the maximum inhibition. EGCG also showed greater inhibitory effects against TPA-caused induction of epidermal ODC activity when compared with several other naturally occurring polyphenols. The results of this study suggest that GTP, specifically its epicatechin derivative EGCG, could provide anti-tumor-promoting effects against a wide spectrum of skin tumor promoters.
METHYLATION OF DNA MAY BE USEFUL AS A COMPUTATIONAL TOOL: EXPERIMENTAL EVIDENCE

Previously we have explained the abstract concept we call ‘aqueous computing’ and illustrated it with concrete wet lab results. Here, we explore the use of methylase enzymes to ‘write’ on double-stranded DNA molecules at sites where restriction enzymes will cut if, and only if, the sites have not previously been methylated. A site represents the bit zero (False, F) if the site has been methylated and the bit one (True, T) if it has not been methylated. ‘Reading’ is done by attempting a cut at each of the sites. We found 8 commercially available methylases and 8 corresponding restriction enzymes that would not cut after the action of one of the methylases. We were able to confirm that methylation by each of these 8 enzymes individually blocked cleavage only by the restriction enzyme associated with that site and not any other enzyme. We then used these enzymes to approach a 3-variable, 4-clause satisfiability (SAT) problem using either plasmid DNA (pBluescript) or PCR product made from the region containing the restriction enzyme sites on the plasmid. Pairs of methylases were defined to represent each of the states of the operators p, q and r, one methylase for p and another for p’, etc. We methylated the DNA in parallel at the two sites so either the p site was methylated (making p false) or the p’ site was methylated (making p’ false). We did that for the other two variables as well to create a set of logically consistent DNA fragments. Then we applied the 4 clauses using restriction enzymes to cut DNA fragments that did not satisfy them. At the end, we found evidence for intact DNA indicating an answer satisfying all of the clauses. To confirm the state of each of the Boolean operators, we used cleavage by the appropriate restriction enzyme. We found in the computation with both the plasmid and the PCR product, one site pair to show false in both sites; q and q’, for instance. This should not be possible. We suspected incomplete cutting during the clauses by one of these restriction enzymes, specifically BssHII. In summary, we did successfully show the usefulness of DNA methylation in a scheme to do a mathematical computation. Thus, we have added to our arsenal of potential methods of performing DNA computing in the aqueous style.
Assessment of Disordered Thinking in Children and Adolescents: The Rorschach Perceptual- Thinking Index

The new Rorschach Perceptual-Thinking Index (PTI; Exner, 2000a, 2000b) was designed to assess thought disorders more accurately than the Schizophrenia Index (SCZI; Exner, 1993). Using a sample of child and adolescent inpatients, we examined the relation of Rorschach variables (PTI, SCZI, M-, and X - %) to thought disorder indexes on a behavior rating scale (Behavior Assessment System for Children; Reynolds & Kamphaus, 1992) and a self-report measure (Personality Inventory for Youth; Lachar & Gruber, 1995). Results indicate that, when used in a categorical manner, the PTI differentiated between those patients with and without elevated thought disorder scores on the other measures. Of all Rorschach variables, M- was most related to the other measures, indicating that this variable may be a particularly robust indicator of thought disorder among children and adolescents.
The use and efficacy of empirical versus pre-emptive therapy in the management of fungal infections: the HEMA e-Chart Project

Background Neutropenic patients with persistent fever despite antibiotic therapy are managed with empirical or pre-emptive antifungal therapy. The aim of the present study was to evaluate the current clinical use and efficacy of these two approaches in patients with high risk hematologic conditions. Design and Methods An electronic medical record system, the “Hema e-Chart”, was designed and implemented to collect information prospectively on infectious complications, particularly on invasive fungal diseases, in patients with hematologic malignancies treated with chemotherapy and/or autologous or allogenic hemopoietic stem cell transplantation. The patients were enrolled from Hematology units distributed widely across Italy. Results Three hundred and ninety-seven adults with hematologic malignancies treated with chemotherapy with persistent fever and suspected invasive fungal disease were evaluable for the study (190 treated had been treated with empirical antifungal therapy and 207 with preemptive antifungal therapy). There was a significantly lower incidence of proven/probable invasive fungal diseases in patients treated with empirical antifungal therapy (n=14, 7.4%) than in patients treated with pre-emptive therapy (n=49, 23.7%) (P<0.001). The rate of deaths attributable to invasive fungal diseases was significantly lower in subjects treated with empirical antifungal therapy (1 case; 7.1%) than in subjects treated with pre-emptive therapy (11 cases; 22.5%) (P=0.002). Conclusions These data indicate that empirical antifungal treatment decreased the incidence of invasive fungal disease and of attributable mortality with respect to a pre-emptive antifungal approach in neutropenic febrile patients with hematologic malignancies. (ClinicalTrials.gov Identifier: NCT01069887)
Arabidopsis thaliana leaves with altered chloroplast numbers and chloroplast movement exhibit impaired adjustments to both low and high light

The effects of chloroplast number and size on the capacity for blue light-dependent chloroplast movement, the ability to increase light absorption under low light, and the susceptibility to photoinhibition were investigated in Arabidopsis thaliana. Leaves of wild-type and chloroplast number mutants with mean chloroplast numbers ranging from 120 to two per mesophyll cell were analysed. Chloroplast movement was monitored as changes in light transmission through the leaves. Light transmission was used as an indicator of the ability of leaves to optimize light absorption. The ability of leaves to deal with 3 h of high light stress at 10 °C and their capacity to recover in low light was determined by measuring photochemical efficiencies of PSII using chlorophyll a fluorescence. Chloroplast movement was comparable in leaves ranging in chloroplast numbers from 120 to 30 per mesophyll cell: the final light transmission levels after exposure to 0.1 (accumulation response) and 100 μmol photons m−2 s−1 (avoidance response) were indistinguishable, the chloroplasts responded quickly to small increases in light intensity and the kinetics of movement were similar. However, when chloroplast numbers per mesophyll cell decreased to 18 or below, the accumulation response was significantly reduced. The avoidance response was only impaired in mutants with nine or fewer chloroplasts, both in terms of final transmission levels and the speed of movement. Only mutants lacking both blue light receptors (phot1/phot2) or those with drastically reduced chloroplast numbers and severely impacted avoidance responses showed a reduced ability to recover from high light stress.
AN INVESTIGATION OF CRITICAL SUCCESS FACTORS IN THE ADOPTION OF B 2 BEC BY TAIWANESE COMPANIES

This exploratory study examines the relevant business-to-business electronic commerce (B2BEC) critical success factors of adopted by the small and medium-size enterprise (SME) sector in Taiwan. Well known for the vibrancy of this sector, Taiwan is embracing and aggressively promoting information technology and ecommerce (i.e., B2BEC) and this is particularly true among many electronic manufacturing industry leaders. Since the economy of Taiwan is so heavily dependant on the performance of small and medium-size electronic enterprises, enhancing their competitiveness is a major, pressing issue. We present here a conceptual model containing fifteen critical success factors and examine whether or not the SME sector uses them to leverage the Internet and realize the benefits of adopting B2BEC.
Asymmetric expression of Notch/Delta/Serrate is associated with the anterior-posterior axis of feather buds.

We studied the roles of Notch, Delta, and Serrate in vertebrate epithelial appendage morphogenesis using feather as a model and found the following. (1) C-Notch-1, C-Delta-1, and C-Serrate-1 are not expressed at the early placode stage and are therefore not involved in the determination of bud versus interbud compartments. (2) From symmetric short buds to asymmetric long buds, C-Delta-1 and C-Serrate-1 are expressed in the posterior bud mesenchyme in a nested fashion, while C-Notch-1 is expressed as a stripe perpendicular to the anterior-posterior (A-P) axis and positioned posterior to the midpoint. (3) Epithelial-mesenchymal recombination with rotation led to the disappearance of these genes followed by their reappearance with new positions appearing to predict their new morphological orientation. (4) Conditions leading to branched buds (e.g., recombination of later buds) show polarized staining patterns before branching occurs. (5) Conditions leading to symmetrical round buds (e.g., treated with the protein kinase A agonist forskolin) suppress expression of all three genes. These results lead us to hypothesize that Notch, Delta, and Serrate are involved in establishing the A-P asymmetry of feather buds.
Can peer instruction be effective in upper-division computer science courses?

Peer Instruction (PI) is an active learning pedagogical technique. PI lectures present students with a series of multiple-choice questions, which they respond to both individually and in groups. PI has been widely successful in the physical sciences and, recently, has been successfully adopted by computer science instructors in lower-division, introductory courses. In this work, we challenge readers to consider PI for their upper-division courses as well. We present a PI curriculum for two upper-division computer science courses: Computer Architecture and Theory of Computation. These courses exemplify several perceived challenges to the adoption of PI in upper-division courses, including: exploration of abstract ideas, development of high-level judgment of engineering design trade-offs, and exercising advanced mathematical sophistication. This work includes selected course materials illustrating how these challenges are overcome, learning gains results comparing these upper-division courses with previous lower-division results in the literature, student attitudinal survey results (N = 501), and pragmatic advice to prospective developers and adopters. We present three main findings. First, we find that these upper-division courses achieved student learning gains equivalent to those reported in successful lower-division computing courses. Second, we find that student feedback for each class was overwhelmingly positive, with 88% of students recommending PI for use in other computer science classes. Third, we find that instructors adopting the materials introduced here were able to replicate the outcomes of the instructors who developed the materials in terms of student learning gains and student feedback.
Agonist Ligands Expressed by Thymic Epithelium Enhance Positive Selection of Regulatory T Lymphocytes from Precursors with a Normally Diverse TCR Repertoire1

CD4+CD25+ regulatory T lymphocytes play a crucial role in inhibition of autoimmune pathology. In accordance with this physiological role, it is now well established that the repertoire of these lymphocytes is strongly enriched in autospecific cells. However, despite extensive investigation, the thymic mechanisms involved in development of regulatory T cells remain incompletely defined. To address the issue of selection of regulatory T cell precursors in mice with a naturally diverse TCR repertoire, we have analyzed development of superantigen-specific regulatory T cells in hemopoietic chimeras in which endogenous super-antigens are exclusively presented by thymic epithelial cells. Our results demonstrate that recognition of agonist ligands expressed by thymic epithelium does not lead to deletion but substantially enhances development of mature regulatory T cells. Interestingly, also development of a small subpopulation of CD25-expressing T cells lacking expression of the transcription factor Foxp3, thought to be autospecific, is enhanced by expression of the agonist ligand on thymic epithelium. Based on quantitative arguments, we propose that commitment to the regulatory T cell lineage is not dictated by the specificity of precursors, but that recognition of the agonist ligand expressed by thymic epithelium substantially enhances their positive selection.
Blending the Real and Virtual: Activity and Spectatorship in Fantasy Sports

Fantasy sports provide participants with the opportunity to play the role of coach for a team of athletes they select. The better the athletes perform in their real-world competitions, the better the virtual teams they are on will perform. Leagues for fantasy sports started almost 40 years ago and have grown to the point that there are now approximately 30 million participants. Initially using paper and pencil, fantasy sports are now growing rapidly due to the ease of organizing and playing in on-line leagues. The use of computers has changed fantasy leagues from being mostly a group of friends or acquaintances in a local community to potentially being anonymous players from around the world. Newer software is countering the trend towards anonymity with the inclusion of features, such as league newspapers, that provide a greater context surrounding the fantasy leagues. The rhetoric found in descriptions and advertising for fantasy sports emphasizes competition, empowerment, and participation. Looking at the activities of current fantasy sports and the rhetoric surrounding them yields a framework based on their use of real versus virtual action and player versus external control. It is the integration of activity in a virtual game and spectatorship of a real sport that makes fantasy sports a model to explore how other entertainment combining virtual and real world activities may be constructed.
Prediction of Zero Quantized DCT Coefficients in H.264/AVC Using Hadamard Transformed Information

This paper presents an efficient approach for detecting zero quantized discrete cosine transform (ZQDCT) coefficients using the sum of absolute transformed difference (SATD). Previously, all the ZQDCT prediction approaches employ the sum of absolute difference (SAD) available ahead of DCT and quantization (Q) for early detection. However, when the Hadamard transform is enabled for H.264/AVC encoding, only the SATD instead of SAD is available before DCT and Q, and all the prediction approaches can not be directly applied. To solve this problem, the Gaussian distribution is applied to study the integer 4x4 DCT coefficients in H.264/AVC and hence an adaptive scheme with multiple thresholds against SATD is derived to realize different types of DCT and Q implementations. In addition, another two SATD based sufficient conditions are proposed for early detecting zero quantized DC coefficients for the luma components encoded with the intra 16 times 16 mode and the chroma components. The experimental results demonstrate that the proposed approach can greatly reduce the DCT and Q computations and obtain almost the same rate-distortion performance as the original encoder.
Common and Unique Neural Correlates of Autobiographical Memory and Theory of Mind

There is an inconsistency regarding the relationship between thinking about personal past experiences during autobiographical memory (AM) and thinking about other people's mental states during theory of mind (ToM). Neuroimaging studies of AM and ToM consistently report overlap in the brain regions recruited. Lesion data, however, show that amnesic people with AM impairment can have intact ToM, suggesting that distinct neural mechanisms support these abilities [Rosenbaum, R. S. , Stuss, D. T. , Levine, B. , & Tulving, E. Theory of mind is independent of episodic memory. Science, 318, 1257, 2007]. The current fMRI study examined the functional and neural correlates of remembering one's own experiences in response to personal photos (AM condition) and imagining others' experiences in response to strangers' photos (ToM condition). AM and ToM conditions were matched in terms of content and vividness, and were compared directly and to a common baseline. Analyses revealed common activity within frontal and temporal–parietal regions, yet midline structures exhibited greater activity during AM. More specific analyses of event construction and detail elaboration revealed unique activation of the right hippocampus during AM construction, and of lateral regions, such as the right temporo-parietal junction (TPJ) during ToM elaboration. Moreover, a region of left hippocampus/perirhinal cortex appeared to be driven by event vividness. Thus, differences in AM and ToM emerge when a common baseline is used and temporal dynamics are taken into account. Furthermore, the right TPJ and related lateral regions, and not the hippocampus, may be needed for ToM, given that this ability is intact in amnesic people.
Strain in layered nanocrystals

Layered nanocrystals consist of a core of one material surrounded by a shell of a second material. We present computation of the atomistic strain energy density in a layered nanocrystal, using an idealised model with a simple cubic lattice and harmonic interatomic potentials. These computations show that there is a critical size r*s for the shell thickness rs at which the energy density has a maximum. This critical size is roughly independent of the geometry and material parameters of the system. Interestingly, this critical size agrees with the shell thickness at which the quantum yield has a maximum, as observed in several systems and thus leads one to support the hypothesis that maximal quantum yield is strongly correlated with maximal elastic energy density.
Architectural Bias in Recurrent Neural Networks: Fractal Analysis

We have recently shown that when initialized with small weights, recurrent neural networks (RNNs) with standard sigmoid-type activation functions are inherently biased toward Markov models; even prior to any training, RNN dynamics can be readily used to extract finite memory machines (Hammer & Tio, 2002; Tio, eransk, &Beukov, 2002a, 2002b). Following Christiansen and Chater (1999), we refer to this phenomenon as the architectural bias of RNNs. In this article, we extend our work on the architectural bias in RNNs by performing a rigorous fractal analysis of recurrent activation patterns. We assume the network is driven by sequences obtained by traversing an underlying finite-state transition diagram&a scenario that has been frequently considered in the past, for example, when studying RNN-based learning and implementation of regular grammars and finite-state transducers. We obtain lower and upper bounds on various types of fractal dimensions, such as box counting and Hausdorff dimensions. It turns out that not only can the recurrent activations inside RNNs with small initial weights be explored to build Markovian predictive models, but also the activations form fractal clusters, the dimension of which can be bounded by the scaled entropy of the underlying driving source. The scaling factors are fixed and are given by the RNN parameters.
Nostalgia-Evoked Inspiration

Six studies examined the nostalgia–inspiration link and its motivational implications. In Study 1, nostalgia proneness was positively associated with inspiration frequency and intensity. In Studies 2 and 3, the recollection of nostalgic (vs. ordinary) experiences increased both general inspiration and specific inspiration to engage in exploratory activities. In Study 4, serial mediational analyses supported a model in which nostalgia increases social connectedness, which subsequently fosters self-esteem, which then boosts inspiration. In Study 5, a rigorous evaluation of this serial mediational model (with a novel nostalgia induction controlling for positive affect) reinforced the idea that nostalgia-elicited social connectedness increases self-esteem, which then heightens inspiration. Study 6 extended the serial mediational model by demonstrating that nostalgia-evoked inspiration predicts goal pursuit (intentions to pursue an important goal). Nostalgia spawns inspiration via social connectedness and attendant self-esteem. In turn, nostalgia-evoked inspiration bolsters motivation.
Multiple recombinant dengue type 1 viruses in an isolate from a dengue patient

Between 2000 and 2004, dengue virus type 1 (DENV-1) genotypes I and II from Asia were introduced into the Pacific region and co-circulated in some localities. Envelope protein gene sequences of DENV-1 from 12 patients infected on the island of New Caledonia were obtained, five of which carried genotype I viruses and six, genotype II viruses. One patient harboured a mixed infection, containing viruses assigned to both genotypes I and II, as well as a number of inter-genotypic recombinants. This is the first report of a population of dengue viruses isolated from a patient containing both parental and recombinant viruses.