Miracle-dz/UniFAR-FTUs huggingface dataset:
Early growth and postprandial appetite regulatory hormone responses

Strong epidemiological evidence suggests that slow prenatal or postnatal growth is associated with an increased risk of CVD and other metabolic diseases. However, little is known whether early growth affects postprandial metabolism and, especially, the appetite regulatory hormone system. Therefore, we investigated the impact of early growth on postprandial appetite regulatory hormone responses to two high-protein and two high-fat content meals. Healthy, 65–75-year-old volunteers from the Helsinki Birth Cohort Study were recruited; twelve with a slow increase in BMI during the first year of life (SGI group) and twelve controls. Subjects ate a test meal (whey meal, casein meal, SFA meal and PUFA meal) once in a random order. Plasma glucose, insulin, TAG, NEFA, ghrelin, peptide tyrosine-tyrosine (PYY), glucose-dependent insulinotropic peptide, glucagon-like peptide-1 and a satiety profile were measured in the fasting state and for 4 h after each test meal. Compared with the controls, the SGI group had about 1·5-fold higher insulin responses after the whey meal (P= 0·037), casein meal (P= 0·023) and PUFA meal (P= 0·002). TAG responses were 34–69 % higher for the SGI group, but only the PUFA-meal responses differed significantly between the groups. The PYY response of the SGI group was 44 % higher after the whey meal (P= 0·046) and 115 % higher after the casein meal (P= 0·025) compared with the controls. No other statistically significant differences were seen between the groups. In conclusion, early growth may have a role in programming appetite regulatory hormone secretion in later life. Slow early growth is also associated with higher postprandial insulin and TAG responses but not with incretin levels.
Debugging OWL ontologies

As an increasingly large number of OWL ontologies become available on the Semantic Web and the descriptions in the ontologies become more complicated, finding the cause of errors becomes an extremely hard task even for experts. Existing ontology development environments provide some limited support, in conjunction with a reasoner, for detecting and diagnosing errors in OWL ontologies. Typically these are restricted to the mere detection of, for example, unsatisfiable concepts. We have integrated a number of simple debugging cues generated from our description logic reasoner, Pellet, in our hypertextual ontology development environment, Swoop. These cues, in conjunction with extensive undo/redo and Annotea based collaboration support in Swoop, significantly improve the OWL debugging experience, and point the way to more general improvements in the presentation of an ontology to new users.
Improved prevention of moderately emetogenic chemotherapy‐induced nausea and vomiting with palonosetron, a pharmacologically novel 5‐HT3 receptor antagonist

Palonosetron, a highly selective and potent 5‐HT3 receptor antagonist with a strong binding affinity and a long plasma elimination half‐life (approximately 40 hours), has shown efficacy in Phase II trials in preventing chemotherapy‐induced nausea and vomiting (CINV) resulting from highly emetogenic chemotherapy. The current Phase III trial evaluated the efficacy and safety of palonosetron in preventing acute and delayed CINV after moderately emetogenic chemotherapy.
Insights in the pathogenesis and resistance of Arcobacter: A review

Abstract Arcobacter genus currently comprises 18 recognized species, among which Arcobacter butzleri, Arcobacter cryaerophilus and Arcobacter skirrowii have been associated with human and animal disease. Although these organisms, with special emphasis A. butzleri, are emerging as clinical pathogens, several aspects of their epidemiology and virulence are only starting to be clarified. In vitro human and animal cell culture assays have been used to show that several Arcobacter species can adhere to and invade eukaryotic cells, induce an immune response and produce toxins that damage host cells. In addition, data from genome sequencing highlighted several potential markers that may be helpful candidates for the study and understanding of these mechanisms; however, more work is necessary to clarify the molecular mechanisms involved in Arcobacter virulence. Arcobacter can be considered a relatively robust organism showing to be able to survive in adverse conditions, as the ones imposed by food processing and storage. Moreover, these bacteria have shown increased antibiotic resistance, along with high multidrug resistance. In this review, we seek to update the state-of-the-art concerning Arcobacter distribution, its interaction with the host, the trends of antibiotic resistance, its ability to survive, and finally the use of natural antimicrobials for control of Arcobacter.
Selective Moral Disengagement in the Exercise of Moral Agency

Moral agency has dual aspects manifested in both the power to refrain from behaving inhumanely and the proactive power to behave humanely. Moral agency is embedded in a broader socio-cognitive self-theory encompassing affective self-regulatory mechanisms rooted in personal standards linked to self-sanctions. Moral functioning is thus governed by self-reactive selfhood rather than by dispassionate abstract reasoning. The self-regulatory mechanisms governing moral conduct do not come into play unless they are activated and there are many psychosocial mechanisms by which moral self-sanctions are selectively disengaged from inhumane conduct. The moral disengagement may centre on the cognitive restructuring of inhumane conduct into a benign or worthy one by moral justification, sanitising language and exonerative social comparison; disavowal of personal agency in the harm one causes by diffusion or displacement of responsibility; disregarding or minimising the injurious effects of one's actions; and attribution of blame to, and dehumanisation of, those who are victimised. Social cognitive theory adopts an interactionist perspective to morality in which moral actions are the products of the reciprocal interplay of personal and social influences. Given the many mechanisms for disengaging moral control at both the individual and collective level, civilised life requires, in addition to humane personal standards, safeguards built into social systems that uphold compassionate behaviour and renounce cruelty.
On the Usefulness or Lack Thereof of Optimality Criteria for Structural Change Tests

Elliott and Müller (2006) considered the problem of testing for general types of parameter variations, including infrequent breaks. They developed a framework that yields optimal tests, in the sense that they nearly attain some local Gaussian power envelop. The main ingredient in their setup is that the variance of the process generating the changes in the parameters must go to zero at a fast rate. They recommended the so-called qL̂L test, a partial sums type test based on the residuals obtained from the restricted model. We show that for breaks that are very small, its power is indeed higher than other tests, including the popular sup-Wald (SW) test. However, the differences are very minor. When the magnitude of change is moderate to large, the power of the test is very low in the context of a regression with lagged dependent variables or when a correction is applied to account for serial correlation in the errors. In many cases, the power goes to zero as the magnitude of change increases. The power of the SW test does not show this non-monotonicity and its power is far superior to the qL̂L test when the break is not very small. We claim that the optimality of the qL̂L test does not come from the properties of the test statistics but the criterion adopted, which is not useful to analyze structural change tests. Instead, we use fixed-break size asymptotic approximations to assess the relative efficiency or power of the two tests. When doing so, it is shown that the SW test indeed dominates the qL̂L test and, in many cases, the latter has zero relative asymptotic efficiency.
SAARC JOURNAL OF EDUCATIONAL RESEARCH

This paper analyzes and determines the various socio-psychological orientations of the undergraduate students at State universities of Iran towards learning English. The study focuses on what is considered as the two most important social psychological variables: attitude and motivation. Domain use is also investigated to know the present linguistics reality of Iran and features important in describing the motivational orientations of students. In effect, the research ultimately shows that students focus on English for its ‘functional role’ (i.e. its utilitarian value) in limited and discrete domain areas where knowledge of English is required. The author contends, therefore, that the Iran linguistic reality impacts these important socio-psychological factors of the learners and ultimately shapes their idea about learning ‘English’. The investigation also demonstrates that the learners learn English for ‘instrumental’ reasons as opposed to previous research conducted in Iran, which concluded that ‘integrative motivation’ as being the dominant motivational orientation for the students to learn English. This study of the social-psychological variables of the students will possibly provide additional insights in better identifying existing motivational challenges and in taking a more realistic perspective about the ELT (English Language Teaching) situation in the country. Finally, some recommendations on future directions for this research area in Iran have been highlighted.
Neural diversity creates a rich repertoire of brain activity

Despite investigations dating back to the 19th century, the functional role of different cell types in the brain remains largely unknown. Using realistic computer simulations, we have recently shown that neural diversity can generate patterns of complex activity that were traditionally interpreted as irreducible noise. Such complex activity may directly contribute to both cognitive and behavioral outcomes, including motor control, perception, and memory.
Relationships among Chinese college students’ defensive pessimism, cultural values, and psychological health

This study examined defensive pessimism, viewed as a self-regulatory strategy in Western cultures, in China among college students, and explored its relationship with Chinese cultural values and students’ psychological health operationalized as adult hope and personal growth initiative. Two-hundred and thirty Chinese students from a comprehensive university in Beijing, China, participated in the study. Data were analyzed by using structural equation modeling. The results showed that all the measures used in the study were valid for our sample. The inferential modeling demonstrated that reflectivity, but not pessimism, subscale of defensive pessimism correlated with Chinese cultural values. Additionally, pessimism and reflectivity predicted psychological health in opposite directions. Reflectivity contributed to hope and positive growth initiative, but pessimism decreased these psychological health indicators. The results seemed to suggest that reflectivity, but not pessimism, captured the essence of defensive pessimism for Chinese college students. Limitations and directions for future research were discussed.
Annual Research Review: Resilience and mental health in children and adolescents living in areas of armed conflict--a systematic review of findings in low- and middle-income countries.

BACKGROUND Researchers focused on mental health of conflict-affected children are increasingly interested in the concept of resilience. Knowledge on resilience may assist in developing interventions aimed at improving positive outcomes or reducing negative outcomes, termed promotive or protective interventions. METHODS We performed a systematic review of peer-reviewed qualitative and quantitative studies focused on resilience and mental health in children and adolescents affected by armed conflict in low- and middle-income countries. RESULTS Altogether 53 studies were identified: 15 qualitative and mixed methods studies and 38 quantitative, mostly cross-sectional studies focused on school-aged children and adolescents. Qualitative studies identified variation across socio-cultural settings of relevant resilience outcomes, and report contextually unique processes contributing to such outcomes. Quantitative studies focused on promotive and protective factors at different socio-ecological levels (individual, family-, peer-, school-, and community-levels). Generally, promotive and protective factors showed gender-, symptom-, and phase of conflict-specific effects on mental health outcomes. CONCLUSIONS Although limited by its predominantly cross-sectional nature and focus on protective outcomes, this body of knowledge supports a perspective of resilience as a complex dynamic process driven by time- and context-dependent variables, rather than the balance between risk- and protective factors with known impacts on mental health. Given the complexity of findings in this population, we conclude that resilience-focused interventions will need to be highly tailored to specific contexts, rather than the application of a universal model that may be expected to have similar effects on mental health across contexts.
The ‘Bravo Mike Syndrome': private security culture and racial profiling in South Africa*

ABSTRACT This article analyses how issues of race influence the occupational culture of the armed response sector, a particular part of the private security industry, in Durban, South Africa. In addition to analysing the racial hierarchy of the industry, this article examines the ‘Bravo Mike Syndrome' – Bravo Mike meaning black male in NATO phonetic alphabet code. The ‘Bravo Mike Syndrome' refers to the racialised imaginaries of criminals and the subsequent policing practices performed by armed response officers to protect clients from this racially constructed dangerous ‘Other’. However, as the majority of armed response officers are ‘Bravo Mikes’ themselves, there is a constant element of friction in their performances. Based on 20 months of ethnographic fieldwork, this article thus analyses how racialised understandings of crime influence, and are reproduced by, private policing practices, thereby contributing to studies on private security occupational cultures and racial profiling.
Child Abuse and Divorce

Summary This article addresses the problem of divorce situations in which there are also allegations of abuse. Its goal is to provide guidance for professionals evaluating these cases. It describes the challenges peculiar to cases where divorce and abuse allegations coexist, relevant research findings, and potential sources of bias. The article suggests a multidisciplinary approach may be the optimal strategy for evaluating these cases. Specific guidelines for evaluation and decision-making are provided.
Selection for Human Immunodeficiency Virus Type 1 Recombinants in a Patient with Rapid Progression to AIDS

ABSTRACT Although human immunodeficiency virus type 1 (HIV-1) recombinants have been found with high frequency, little is known about the forces that select for these viruses or their importance to pathogenesis. Here we document the emergence and dynamics of 11 distinct HIV-1 recombinants in a man who was infected with two subtype B HIV-1 strains and progressed rapidly to AIDS without developing substantial cellular or humoral immune responses. Although numerous frequency oscillations were observed, a single recombinant lineage eventually came to dominate the population. Numerical simulations indicate that the successive recombinant forms displaced each other too rapidly to be explained by any simple model of random genetic drift or sampling variation. All of the recombinants, including several resulting from independent recombination events, possessed the same sequence motif in the V3 loop, suggesting intense selection on this segment of the viral envelope protein. The outgrowth of the predominant V3 loop recombinants was not, however, associated with changes in coreceptor utilization. The final variant was instead notable for having lost 3 of 14 potential glycosylation sites. We also observed high ratios of synonymous-to-nonsynonymous nucleotide changes—suggestive of purifying selection—in all viral populations, with particularly high ratios in newly arising recombinants. Our study, therefore, illustrates the unusual and important patterns of viral adaptation that can occur in a patient with weak immune responses. Although it is hard to tease apart cause and effect in a single patient, the correlation with disease progression in this patient suggests that recombination between divergent viruses, with its ability to create chimeras with increased fitness, can accelerate progression to AIDS.
High-Resolution Imaging of CO Outflows in OMC-2 and OMC-3

A large-scale, high-resolution map of CO (1-0) emission toward the OMC-2 and OMC-3 star-forming regions is presented. The map is a mosaic of 46 fields using the Berkeley-Illinois-Maryland Array (BIMA) and covers ~10′ × 15′ at ~10'' resolution. These data are combined with single-dish FCRAO observations and analyzed to identify and determine the properties of nine protostellar outflows. The BIMA data alone almost completely resolve out the cloud emission at central velocities and only recover 1/20 of the flux in the high-velocity gas, showing that outflows are generally broadly dispersed over ~1' angular scales. All nine identified outflows emanate from known Class 0 or borderline Class 0/I sources, are associated with knots of shocked H2 emission, and have short dynamical times. It is suggested that only the youngest, most spatially compact, and energetic outflows have been found and that more distributed high-velocity gas undetected by BIMA is due to older outflows continuing through the Class I phase of protostellar evolution. The mechanical energy injection rate into the cloud is estimated to be ~1.5 L☉, which is comparable to the turbulent energy dissipation rate. Outflows appear capable, therefore, of sustaining cloud turbulence but a high star formation rate is required, implying a short cloud lifetime of ≤5 Myr.
Brain Structures in Verbal Communication: A Focus on Prosody

Abstract Human communication is made up of three domains: speech, language, and pragmatics, which can be fully specified as a set of rules, units, and practices. Prosodic function spans these domains. Neurolinguistic studies utilizing an array of disparate techniques reveal that many parts of the brain are required for normal communicative function. Speech and language are largely lateralized to the left cerebral hemisphere, while pragmatic competence appears to require an intact right hemisphere. Familiarity agnosias have been associated with right hemisphere dysfunction, leading to an explanation for preserved familiar proper noun recognition in severe aphasia. This model pertains to the adult brain; due to the poorly understood phenomenon of cerebral plasticity, laterality of function in children is established weakly and slowly. The basal ganglia may subserve well-known phrasal structures such as that seen in “automatic speech,” and some kinds of prosodic competence, both in production and perception. A thorough model of language and the brain takes into account two horizontal and one vertical dimension: the left-right dimension of hemispheric model differences; the anterior-posterior dimension reflecting sensory and motor processes; and the vertical interaction of cortical and subcortical processes. All of these participate crucially in the different domains of communication.
PCC: Re-architecting Congestion Control for Consistent High Performance

TCP and its variants have suffered from surprisingly poor performance for decades. We argue the TCP family has little hope of achieving consistent high performance due to a fundamental architectural deficiency: hardwiring packet-level events to control responses. We propose Performance-oriented Congestion Control (PCC), a new congestion control architecture in which each sender continuously observes the connection between its actions and empirically experienced performance, enabling it to consistently adopt actions that result in high performance. We prove that PCC converges to a stable and fair equilibrium. Across many real-world and challenging environments, PCC shows consistent and often 10× performance improvement, with better fairness and stability than TCP. PCC requires no router hardware support or new packet format.
Teachers' Perceptions About Minimal Hearing Loss

A 25-item survey was administered to 45 teachers to identify what they knew about Minimal Hearing Loss (MHL) and to verify or refute five possible misperceptions reported earlier by Goldberg and McCormick Richburg (2004). Results support the importance of an educational audiologist on the service delivery team to help teachers understand the ramifications of MHL and assist in meeting the educational and psychosocial needs of students with this type of loss. Results also suggest areas for in-service education for classroom teachers, especially regarding the issue of preferential seating.
Efficient Differentiation of Steroidogenic and Germ-Like Cells from Epigenetically-Related iPSCs Derived from Ovarian Granulosa Cells

To explore restoration of ovarian function using epigenetically-related, induced pluripotent stem cells (iPSCs), we functionally evaluated the epigenetic memory of novel iPSC lines, derived from mouse and human ovarian granulosa cells (GCs) using c-Myc, Klf4, Sox2 and Oct4 retroviral vectors. The stem cell identity of the mouse and human GC-derived iPSCs (mGriPSCs, hGriPSCs) was verified by demonstrating embryonic stem cell (ESC) antigen expression using immunocytochemistry and RT-PCR analysis, as well as formation of embryoid bodies (EBs) and teratomas that are capable of differentiating into cells from all three germ layers. GriPSCs’ gene expression profiles associate more closely with those of ESCs than of the originating GCs as demonstrated by genome-wide analysis of mRNA and microRNA. A comparative analysis of EBs generated from three different mouse cell lines (mGriPSCs; fibroblast-derived iPSC, mFiPSCs; G4 embryonic stem cells, G4 mESCs) revealed that differentiated mGriPSC-EBs synthesize 10-fold more estradiol (E2) than either differentiated FiPSC- or mESC-EBs under identical culture conditions. By contrast, mESC-EBs primarily synthesize progesterone (P4) and FiPSC-EBs produce neither E2 nor P4. Differentiated mGriPSC-EBs also express ovarian markers (AMHR, FSHR, Cyp19a1, ER and Inha) as well as markers of early gametogenesis (Mvh, Dazl, Gdf9, Boule and Zp1) more frequently than EBs of the other cell lines. These results provide evidence of preferential homotypic differentiation of mGriPSCs into ovarian cell types. Collectively, our data support the hypothesis that generating iPSCs from the desired tissue type may prove advantageous due to the iPSCs’ epigenetic memory.