Miracle-dz/UniFAR-FTUs huggingface dataset:
Blood pressure and its associated factors among primary school children in suburban Selangor, Malaysia: A cross-sectional survey

Background: Little is known about the relationship of blood pressure (BP) with adiposity indicators, dietary habits, physical activity, and sleep in school children in Malaysia. We aimed to study about the distribution of BP and its associated factors in primary school children. Materials and Methods: A survey was carried out on a random sample of 335 children in five primary schools. BP was measured with a mercury sphygmomanometer. Anthropometry was done by standard methods. Demographic information, dietary habits, physical activity, and duration of sleep were collected by interviews. World Health Organization classification based on body mass index (BMI) and waist circumference (WC) cut-offs were used to define overweight/obesity. Elevated BP was defined according to US reference standards. Results: A total 335 children (144 boys and 191 girls) were examined. Their mean age was 9.18 years (standard deviation [SD] = 0.28). Overall mean systolic blood pressure (SBP) and mean diastolic blood pressure (DBP) were 99.32 mmHg (SD = 10.79) and 67.11 mmHg (SD = 10.76), respectively. Mean BMI and WC were 16.39 (SD = 3.58) and 57.77 cm (SD = 8.98), respectively. The prevalence of pre-hypertension was 12.23% (95% confidence intervals [CIs] 8.73, 15.75) and hypertension was 13.4% (95% CIs 9.78, 17.09). Mean SBP and DBP was higher among overweight and obese children than normal children. By multivariate linear regression analyses, BMI (β = 0.250, P = 0.049) and WC (β = 0.308, P = 0.015) were positively associated with SBP; age (β = 0.111, P = 0.017), BMI (β = 0.320, P = 0.012) were positively associated with DBP but total (weekly) hours of sleep (β = −0.095, P = 0.037) was negatively associated with DBP. Conclusion: BP was associated with BMI and WC. Health promotion activities should be initiated in primary schools.
A foetal energy balance equation based on maternal exercise and diet

Empirical data indicate that the maternal diet composition has a direct impact on foetal fat mass and resulting birth weights. Weight-bearing maternal exercise influences the placental volume, which has also been correlated to birth weight. A foetal energy balance equation, based on the first law of thermodynamics, that incorporates maternal diet and exercise is developed. Model parameters and validity are evaluated using published data.
NF-κB-Dependent Role for Cold-Inducible RNA Binding Protein in Regulating Interleukin 1β

The cold inducible RNA binding protein (CIRBP) responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. CIRBP can bind the 3'untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. Here we used RNA interference and oligonucleotide microarrays to identify potential downstream targets of CIRBP induced in response to UVC. Twenty eight transcripts were statistically increased in response to UVC and these exhibited a typical UVC response. Only 5 of the 28 UVC-induced transcripts exhibited a CIRBP-dependent pattern of expression. Surprisingly, 3 of the 5 transcripts (IL1B, IL8 and TNFAIP6) encoded proteins important in inflammation with IL-1β apparently contributing to IL8 and TNFAIP6 expression in an autocrine fashion. UVC-induced IL1B expression could be inhibited by pharmacological inhibition of NFκB suggesting that CIRBP was affecting NF-κB signaling as opposed to IL1B mRNA stability directly. Bacterial lipopolysaccharide (LPS) was used as an activator of NF-κB to further study the potential link between CIRBP and NFκB. Transfection of siRNAs against CIRBP reduced the extent of the LPS-induced phosphorylation of IκBα, NF-κB DNA binding activity and IL-1β expression. The present work firmly establishes a novel link between CIRBP and NF-κB signaling in response to agents with diverse modes of action. These results have potential implications for disease states associated with inflammation.
Post-Transfusion Occult Hepatitis B (OBI): A Global Challenge for Blood Recipients and Health Authorities

Hepatitis B is one of the most frequent post-transfusion infections. Occult hepatitis B infection (OBI) is a form of hepatitis B infection in which, despite the presence of HBV-DNA in the serum and hepatocytes of the carrier, HBsAg is absent. In addition to the risk of transmission through the transfusion of infected blood, reactivation of hepatitis B in OBI patients and recipients of their blood can lead to cirrhosis, hepatic cancer, and reactivation of viral replication in the carrier. Therefore, effective assays to assess and screen for OBI in blood donors are of paramount importance and require urgent attention. Recently, several investigations in various regions of Iran have reported OBI in blood donors. In response, there has been a drive to apply more specific, sensitive, and accurate methods for the detection of HBV, which should become an obligatory screening process for all blood transfusion services. In this review, we address the progression of occult hepatitis B and the common problems associated with occult hepatitis B worldwide. Finally, we reflect on the research and screening that is being performed in Iran to deal with this problem.
Evaluation of CYP3A‐mediated drug–drug interactions with romidepsin in patients with advanced cancer

Two multicenter, single‐arm, single‐infusion, open‐label studies were conducted to evaluate the effect of ketoconazole (a strong CYP3A inhibitor) or rifampin (a strong CYP3A inducer) daily for 5 days on the pharmacokinetics (PK) and safety of romidepsin (8 mg/m2 intravenous 4‐hour infusion for the ketoconazole study or a 14 mg/m2 intravenous 4‐hour infusion for the rifampin study) in patients with advanced cancer. Romidepsin coadministered with ketoconazole (400 mg) or rifampin (600 mg) was not bioequivalent to romidepsin alone. With ketoconazole, the mean romidepsin AUC and Cmax were increased by approximately 25% and 10%, respectively. With rifampin, the mean romidepsin AUC and Cmax were unexpectedly increased by approximately 80% and 60%, respectively; this is likely because of inhibition of active liver uptake. For both studies, romidepsin clearance and volume of distribution were decreased, terminal half‐life was comparable, and median Tmax was similar. Overall, the safety profile of romidepsin was not altered by coadministration with ketoconazole or rifampin, except that a higher incidence and greater severity of thrombocytopenia was observed when romidepsin was given with rifampin. The use of romidepsin with rifampin and strong CYP3A inducers should be avoided. Toxicity related to romidepsin exposure should be monitored when romidepsin is given with strong CYP3A inhibitors.
Author Profiling for Vietnamese Blogs

This paper presents the first work in the task of author profiling for Vietnamese blogs. This task is important in threat identification and marketing intelligence. We have developed a Vietnamese Blog Profiling framework to automatically predict age, gender, geographic origin and occupation of weblogs’ authors purely based on language use. The experiments on the blogs corpus we collected show very promising results with accuracy of around 80% across all traits.
Understanding the Relationship between Scaffolding and the Zone of Proximal development

As the focus of Australian educational research has shifted to studying the quality of teacher intervention, the notion of scaffolding is becoming increasingly popular among educators in different areas such as literacy and numeracy, early childhood education and educational psychology for adults. Vygotskian socio-cultural psychology, and the zone of proximal development (ZPD) in particular, is commonly referred to as the theoretical underpinnings of scaffolding. However, the interpretation of the term and its implementation varies significantly from study to study. An oversimplified approach to scaffolding can lead to its interpretation as direct instruction which is a concern. This paper examines the ways that scaffolding has been interpreted, defined and implemented in educational research. The definitions and explanations of scaffolding in modern texts on educational psychology for pre-service teachers are also reviewed. The ways that different aspects of the concept of the zone of proximal development have been reflected and utilised are analysed.
Phenytoin Reduces Calcium Current in the Cardiac Purkinje Fiber

We have investigated the effects of phenytoin on the electrical and mechanical activity of isolated calf and dog cardiac Purkinje fibers. Phenytoin (5–100αM) lowers and shortens the plateau phase of the Purkinje fiber action potential and reduces twitch tension. We studied the ionic basis of these effects by combining a conventional rwo-microelectrode voltage clamp procedure with pharmacological techniques that allow separation of time-dependent plateau membrane currents. We find that phenytoin reduces voltage-dependent calcium current in the Purkinje fiber. In addition, this drug slightly reduces two time-dependent outward currents. These effects of phenytoin on membrane current account, at least in part, for its influence on the action potential and twitch tension.
Four Dimensional Digital Tomosynthesis Using on-Board Imager for the Verification of Respiratory Motion

Purpose To evaluate respiratory motion of a patient by generating four-dimensional digital tomosynthesis (4D DTS), extracting respiratory signal from patients' on-board projection data, and ensuring the feasibility of 4D DTS as a localization tool for the targets which have respiratory movement. Methods and Materials Four patients with lung and liver cancer were included to verify the feasibility of 4D-DTS with an on-board imager. CBCT acquisition (650–670 projections) was used to reconstruct 4D DTS images and the breath signal of the patients was generated by extracting the motion of diaphragm during data acquisition. Based on the extracted signal, the projection data was divided into four phases: peak-exhale phase, mid-inhale phase, peak-inhale phase, and mid-exhale phase. The binned projection data was then used to generate 4D DTS, where the total scan angle was assigned as ±22.5° from rotation center, centered on 0° and 180° for coronal “half-fan” 4D DTS, and 90° and 270° for sagittal “half-fan” 4D DTS. The result was then compared with 4D CBCT which we have also generated with the same phase distribution. Results The motion of the diaphragm was evident from the 4D DTS results for peak-exhale, mid-inhale, peak-inhale and mid-exhale phase assignment which was absent in 3D DTS. Compared to the result of 4D CBCT, the view aliasing effect due to arbitrary angle reconstruction was less severe. In addition, the severity of metal artifacts, the image distortion due to presence of metal, was less than that of the 4D CBCT results. Conclusion We have implemented on-board 4D DTS on patients data to visualize the movement of anatomy due to respiratory motion. The results indicate that 4D-DTS could be a promising alternative to 4D CBCT for acquiring the respiratory motion of internal organs just prior to radiotherapy treatment.
Identification and functional characterization of the bovine manganous superoxide dismutase promoter.

Manganous superoxide dismutase (MnSOD) gene expression is stimulated by endotoxin, tumor necrosis factor, and interleukin-1, agents thought to cause cellular damage through intracellular generation of reactive oxygen species. To study the molecular mechanisms underlying the induction of MnSOD mRNA by these stimuli, we cloned a bovine MnSOD cDNA and used it to isolate the promoter region of the bovine MnSOD gene. A 14 kb genomic DNA fragment (lambda BS1) containing the first and second exons and 5' flanking region of the gene was characterized. The transcription start site was determined by primer extension and S1 nuclease protection assays and found to be 88 bp upstream of the translation initiation codon. The sequence of approximately 1 kb of DNA upstream of the start site was determined and examined for potential regulatory elements. DNA immediately upstream of the transcription start site was GC-rich and contained two AP-2 and eight Sp-1 consensus sequences. It did not contain either a CCAAT or TATA box. A 956 bp fragment of this DNA fragment was transcriptionally active when fused to a luciferase reporter gene and transfected into both bovine pulmonary artery endothelial and hamster insulinoma tumor cells. Transfection analysis of three additional deletion mutants, whose 5' end-points were -317, -182, and -70 bp, respectively, showed a step-like reduction in transfection efficiency, suggesting the presence of regulatory elements throughout this DNA fragment that contribute to transcriptional activity of the MnSOD promoter. Despite the high homology of the bovine MnSOD cDNA to other mammalian MnSODs, the promoter sequences of bovine and rat MnSOD genes showed a virtual lack of similarity. (ABSTRACT TRUNCATED AT 250 WORDS)
Risk factors for fatal and nonfatal repetition of suicide attempts: a literature review

Objectives This review aimed to identify the evidence for predictors of repetition of suicide attempts, and more specifically for subsequent completed suicide. Methods We conducted a literature search of PubMed and Embase between January 1, 1991 and December 31, 2009, and we excluded studies investigating only special populations (eg, male and female only, children and adolescents, elderly, a specific psychiatric disorder) and studies with sample size fewer than 50 patients. Results The strongest predictor of a repeated attempt is a previous attempt, followed by being a victim of sexual abuse, poor global functioning, having a psychiatric disorder, being on psychiatric treatment, depression, anxiety, and alcohol abuse or dependence. For other variables examined (Caucasian ethnicity, having a criminal record, having any mood disorders, bad family environment, and impulsivity) there are indications for a putative correlation as well. For completed suicide, the strongest predictors are older age, suicide ideation, and history of suicide attempt. Living alone, male sex, and alcohol abuse are weakly predictive with a positive correlation (but sustained by very scarce data) for poor impulsivity and a somatic diagnosis. Conclusion It is difficult to find predictors for repetition of nonfatal suicide attempts, and even more difficult to identify predictors of completed suicide. Suicide ideation and alcohol or substance abuse/dependence, which are, along with depression, the most consistent predictors for initial nonfatal attempt and suicide, are not consistently reported to be very strong predictors for nonfatal repetition.
A Distributed Technique for Dynamic Operator Placement in Wireless Sensor Networks

We present an optimal distributed algorithm to adapt the placement of a single operator in high communication cost networks, such as a wireless sensor network. Our parameter-free algorithm finds the optimal node to host the operator with minimum communication cost overhead. Three techniques, proposed here, make this feature possible: 1) identifying the special, and most frequent case, where no flooding is needed, otherwise 2) limitation of the neighborhood to be flooded and 3) variable speed flooding and eves-dropping. When no flooding is needed the communication cost overhead for adapting the operator placement is negligible. In addition, our algorithm does not require any extra communication cost while the query is executed. In our experiments we show that for the rest of cases our algorithm saves 30%-85% of the energy compared to previously proposed techniques. To our knowledge this is the first optimal and distributed algorithm to solve the 1-median (Fermat node) problem.
Nucleolar stress with and without p53

A veritable explosion of primary research papers within the past 10 years focuses on nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis consuming ~80% of a cell’s energy, nearly all metabolic and signaling pathways lead ultimately to or from the nucleolus. We begin by describing p53 activation upon nucleolar stress resulting in cell cycle arrest or apoptosis. The significance of this mechanism cannot be understated, as oncologists are now inducing nucleolar stress strategically in cancer cells as a potential anti-cancer therapy. We also summarize the human ribosomopathies, syndromes in which ribosome biogenesis or function are impaired leading to birth defects or bone narrow failures; the perplexing problem in the ribosomopathies is why only certain cells are affected despite the fact that the causative mutation is systemic. We then describe p53-independent nucleolar stress, first in yeast which lacks p53, and then in other model metazoans that lack MDM2, the critical E3 ubiquitin ligase that normally inactivates p53. Do these presumably ancient p53-independent nucleolar stress pathways remain latent in human cells? If they still exist, can we use them to target >50% of known human cancers that lack functional p53?
The Role of Networks in Fundamental Organizational Change

Utilizing a grounded-theory approach, this study examines 8 organizations and finds that social networks make a difference in the capability of organizations to implement fundamental organizational change. Specifically, this study examines whether networks enable the learning required for local units to develop the new schemata—understandings, behaviors, and interaction patterns—required to adopt and appropriate planned organization-wide change. A mixture of organization-wide and local learning networks in organizations successfully implemented change, whereas the unsuccessful organizations relied primarily on hierarchical change implementation networks. In accelerated change units compared to those that are lagging, a greater abundance and diversity of networks, strong and weak, internal and external, and across system levels were found. These network connections facilitate change implementation not only by sharing information but also by providing the capabilities to exchange and combine knowledge and by enabling local self-design.
Control of automated behavior: insights from the discrete sequence production task

Work with the discrete sequence production (DSP) task has provided a substantial literature on discrete sequencing skill over the last decades. The purpose of the current article is to provide a comprehensive overview of this literature and of the theoretical progress that it has prompted. We start with a description of the DSP task and the phenomena that are typically observed with it. Then we propose a cognitive model, the dual processor model (DPM), which explains performance of (skilled) discrete key-press sequences. Key features of this model are the distinction between a cognitive processor and a motor system (i.e., motor buffer and motor processor), the interplay between these two processing systems, and the possibility to execute familiar sequences in two different execution modes. We further discuss how this model relates to several related sequence skill research paradigms and models, and we outline outstanding questions for future research throughout the paper. We conclude by sketching a tentative neural implementation of the DPM.
Soluble levels of CD27 and CD30 are associated with risk of non‐Hodgkin lymphoma in three Chinese prospective cohorts

Prospective studies conducted in Western populations have suggested that alterations in soluble CD27 (sCD27) and soluble CD30 (sCD30), two markers indicative of B‐cell activation, are associated with risk of non‐Hodgkin lymphoma (NHL). Given that the characteristics of NHL in East Asia differ from the West and mechanistic commonalities between these populations with respect to the role of intermediate endpoint biomarkers in lymphomagenesis have not been explored, we conducted a pooled nested case‐control study from three prospective studies of Chinese men and women including 218 NHL cases and 218 individually matched controls. Compared with the lowest quartile, ORs (95% CIs) for the second, third and fourth quartiles of sCD27 were 1.60 (0.83–3.09), 1.94 (0.98–3.83) and 4.45 (2.25–8.81), respectively (ptrend = 0.000005). The corresponding ORs for sCD30 were 1.74 (0.85–3.58), 1.86 (0.94–3.67) and 5.15 (2.62–10.12; ptrend = 0.0000002). These associations remained statistically significant in individuals diagnosed with NHL 10 or more years after blood draw. Notably, the magnitude of the associations with NHL risk was very similar to those in Western populations in previous studies. These findings of the similar association between sCD27 or sCD30 and NHL risk across different populations support an important underlying mechanism of B‐cell activation in lymphomagenesis.
Raptor codes

LT-codes are a new class of codes introduced by Luby for the purpose of scalable and fault-tolerant distribution of data over computer networks. In this paper, we introduce Raptor codes, an extension of LT-codes with linear time encoding and decoding. We will exhibit a class of universal Raptor codes: for a given integer k and any real epsiv>0, Raptor codes in this class produce a potentially infinite stream of symbols such that any subset of symbols of size k(1+epsiv) is sufficient to recover the original k symbols with high probability. Each output symbol is generated using O(log(1/epsiv)) operations, and the original symbols are recovered from the collected ones with O(klog(1/epsiv)) operations. We will also introduce novel techniques for the analysis of the error probability of the decoder for finite length Raptor codes. Moreover, we will introduce and analyze systematic versions of Raptor codes, i.e., versions in which the first output elements of the coding system coincide with the original k elements
Graphical models for preference and utility

Probabilistic independence can dramatically simplify the task of eliciting, representing, and computing with probabilities in large domains. A key technique in achieving these benefits is the idea of graphical modeling. We survey existing notions of independence for utility functions in a multi-attribute space, and suggest that these can be used to achieve similar advantages. Our new results concern conditional additive independence, which we show always has a perfect representation as separation in an undirected graph (a Markov network). Conditional additive independencies entail a particular functional form for the utility function that is analogous to a product decomposition of a probability function, and confers analogous benefits. This functional form has been utilized in the Bayesian network and influence diagram literature, but generally without an explanation in terms of independence. The functional form yields a decomposition of the utility function that can greatly speed up expected utility calculations, particularly when the utility graph has a similar topology to the probabilistic network being used.