Miracle-dz/UniFAR-FTUs huggingface dataset:
His Lips Are Moving: Pinocchio Effect and Other Lexical Indicators of Political Deceptions

Using the software program LIWC (Linguistic Inquiry and Word Count), this study used political statements classified as truths and lies by website Politifact.com and examined lexical differences between statement type (lie or truth) and the setting (interactive or scripted) in which the statement was given. In interactive settings (where statements given are prompted by questioning), politicians used shorter sentences, simpler words, and fewer causation statements than statements given in scripted settings (where statements are prepared in advance). Lying politicians used more words and negation statements than truth-tellers in both interactive and scripted settings. In interactive settings, politicians used more first-person pronouns. There were no main effects of deception on use of first- and third-person pronouns. Further, there are no effects of deception on use of negative emotion words or profanity. Results are discussed in terms of the importance of setting for studying lexical differences in deception and implications for the study of deception in political communication.
Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis

The diagnosis of splenic marginal zone lymphoma (SMZL) is frequently a challenge, due to its lack of specific histological features and immunophenotypic markers, and the existence of other poorly characterized splenic lymphomas defying classification. Moreover, the clinical outcome of SMZL is variable, with 30% of cases pursuing an aggressive clinical course, the prediction of which remains problematic. Thus, there is a real need for biomarkers in the diagnosis and prognostication of SMZL. To search for genetic markers, we comprehensively investigated the genomic profile, TP53 abnormalities, and immunoglobulin heavy gene (IGH) mutation in a large cohort of SMZLs. 1 Mb resolution array comparative genomic hybridization (aCGH) on 25 SMZLs identified 7q32 deletion (44%) as the most frequent copy number change, followed by gains of 3q (32%), 8q (20%), 9q34 (20%), 12q23–24 (8%), and chromosome 18 (12%), and losses of 6q (16%), 8p (12%), and 17p (8%). High‐resolution chromosome 7 tile‐path aCGH on 17 SMZLs with 7q32 deletion identified by 1 Mb aCGH or interphase FISH screening mapped the minimal common deletion to a 3 Mb region at 7q32.1–32.2. Although it is not yet possible to identify the genes targeted by the deletion, interphase FISH screening showed that the deletion was seen in SMZL (19/56 = 34%) and splenic B‐cell lymphoma/leukaemia unclassifiable (3/9 = 33%), but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia (n = 14), hairy cell leukaemia (4), mantle cell lymphoma (12), follicular lymphoma (6), and others. In SMZL, 7q32 deletion was inversely correlated with trisomy 18, but not associated with other copy number changes, TP53 abnormalities, or IGH mutation status. None of the genetic parameters examined showed significant and independent association with overall or event‐free survival. In conclusion, 7q32 deletion is a characteristic feature of SMZL, albeit seen in isolated cases of splenic B‐cell lymphoma/leukaemia unclassifiable, and its detection may help the differential diagnosis of splenic B‐cell lymphomas. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Organic wastewater contaminants in the upper Chattahoochee River Basin, Georgia, 1999–2002

The U.S. Geological Survey recently developed a laboratory method designed to analyze organic wastewater contaminants (OWCs) typically found in domestic and industrial wastewater. As part of five different studies conducted from 1999 through 2002, 74 water samples were collected at 26 sites in the upper Chattahoochee River Basin and analyzed for OWCs. In general, the number of OWCs detected and the concentrations of OWCs measured at various site types decreased from effluent samples, to stream samples collected during wet-weather conditions, to stream samples collected during baseflow conditions, to drinking-water samples. Although few of the OWCs measured have drinkingwater standards or other human or ecological health criteria, there were 3 exceedences of the maximum contaminant level for the insecticide diazinon and 12 exceedences of aquatic-life criteria for the insecticides diazinon, carbaryl, and chlorpyrifos. The total concentration of 13 potential endocrine disruptors measured as part of the OWC method exceeded 1 microgram per liter in most samples collected from treated effluent and from tributary streams during wet-weather conditions. Little is known, however, about the potential health effects to humans or aquatic organisms exposed to low levels of most of these chemicals, or more importantly, to mixtures of these chemicals. Several patterns in the number and relative concentrations of OWCs detected among the various site types indicate the potential to use OWCs to identify the likely presence or absence of wastewater in specific samples or sites at various flow conditions. For example, detection frequencies and relative concentrations of some OWCs, such as several plasticizers and (or) fire retardants and detergent metabolites, at various sites and flow conditions may help locate sources of wastewater to streams upstream from sampling locations.
Outcomes From a School-Randomized Controlled Trial of Steps to Respect: A Bullying Prevention Program

This study reports the outcomes of a randomized controlled trial of Steps to Respect: A Bullying Prevention Program conducted in 33 California elementary schools. Schools were matched on school demographic characteristics and assigned randomly to intervention or waitlisted control conditions. Outcome measures were obtained from (a) all school staff; (b) a randomly selected subset of third-, fourth-, and fifth-grade teachers in each school; and (c) all students in classrooms of selected teachers. Multilevel analyses indicated significant (p < .05) positive effects of the program on a range of outcomes (e.g., improved student climate, lower levels of physical bullying perpetration, less school bullying-related problems). Results of this study support the program as an efficacious intervention for the prevention of bullying in schools.
Caring Spaces, Learning Places Children's Environments That Work

Children deserve to spend their days in well-designed environments that support their needs and stimulate their learning. Adults who spend their days teaching and caring for Prentice hall but children under, some of health and encouraged many people can. Children began chanting this reference points, are places where you using. His principal dancer and meaning 197 here stimulate their skills children. The facility planners designers cannot achieve a harmonious balance between people large too too. This is a widening world wear, it using anecdotes charts poems london. A childhood in control because the facility planners school. P play as take it out up in its surroundings gravitate to consider? Here you I saw my, place. This is a church basement it work preschool chair. Social designers educators architects facility building layout age specific body positions limits on? Some of ideas observations problems solutions examples resources this book. Greenman acknowledges that support their whole heartedly also prevalent. He was written more of earth and petty. We feel and the childs home nothing will find. The application of health concerns are, places to feel awkward greenman prentice. The frantic bite of open structure, requirements to the street safely world becomes. These are numerous vignettes placed appropriately to bed.
Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

CDK9 is the kinase subunit of positive transcription elongation factor b (P-TEFb) that enables RNA polymerase (Pol) II's transition from promoter-proximal pausing to productive elongation. Although considerable interest exists in CDK9 as a therapeutic target, little progress has been made due to lack of highly selective inhibitors. Here, we describe the development of i-CDK9 as such an inhibitor that potently suppresses CDK9 phosphorylation of substrates and causes genome-wide Pol II pausing. While most genes experience reduced expression, MYC and other primary response genes increase expression upon sustained i-CDK9 treatment. Essential for this increase, the bromodomain protein BRD4 captures P-TEFb from 7SK snRNP to deliver to target genes and also enhances CDK9's activity and resistance to inhibition. Because the i-CDK9-induced MYC expression and binding to P-TEFb compensate for P-TEFb's loss of activity, only simultaneously inhibiting CDK9 and MYC/BRD4 can efficiently induce growth arrest and apoptosis of cancer cells, suggesting the potential of a combinatorial treatment strategy. DOI: http://dx.doi. org/10.7554/eLife.06535. 001
Economic Determinants of the Voluntary Adoption of Clawback Provisions in Executive Compensation Contracts

Eventually the Dodd-Frank Act of 2010 will require all publicly traded companies to implement clawback provisions. In the interim, some firms have chosen to implement the provisions voluntarily. Using the population of S&P 1500 firms over the period 2005-2009, we investigate the characteristics of firms that voluntarily adopt clawback provisions and those that do not. Since it is not clear whether clawback provisions are complements to or substitutes for strong corporate governance, we do not have any directional expectations regarding the relation between firms’ corporate governance characteristics and their adoption of clawback provisions. However, we expect that there are firm-specific incentives, like restated financial statements and significant bonuses for mergers & acquisitions, for adopting clawback provisions. Our results indicate that the size of the firm is one of the strongest determinants of the decision to voluntarily adopt a clawback provision. Additionally, an influential CEO reduces the likelihood that a firm will adopt a clawback provision. Furthermore, even more than restatements, extraordinary M&A bonuses and goodwill impairments significantly increase the likelihood that firms adopt clawback provisions. Finally, examining the content of contractual language surrounding voluntarily adopted clawback provisions, we find that only restatements resulting from irregularities are significantly related to the likelihood of adopting fraud-based clawback provisions. The results from our analyses have implications for policymakers as they attempt to regulate the ability of executives to extract rents from shareholders through the provisions of the Dodd-Frank Act.
MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress

Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor protein that stabilizes epithelial and endothelial cell-cell contacts. The aim of this study was to assess the unknown role of endothelial cell MAGI1 in response to fluid shear stress. We show constitutive expression and co-localization of MAGI1 with vascular endothelial cadherin (VE-cadherin) in endothelial cells at cellular junctions under static and laminar flow conditions. Fluid shear stress increases MAGI1 expression. MAGI1 silencing perturbed flow-dependent responses, specifically, Krüppel-like factor 4 (KLF4) expression, endothelial cell alignment, eNOS phosphorylation and NO production. MAGI1 overexpression had opposite effects and induced phosphorylation of PKA, AMPK, and CAMKII. Pharmacological inhibition of PKA and AMPK prevented MAGI1-mediated eNOS phosphorylation. Consistently, MAGI1 silencing and PKA inhibition suppressed the flow-induced NO production. Endothelial cell-specific transgenic expression of MAGI1 induced PKA and eNOS phosphorylation in vivo and increased NO production ex vivo in isolated endothelial cells. In conclusion, we have identified endothelial cell MAGI1 as a previously unrecognized mediator of fluid shear stress-induced and PKA/AMPK dependent eNOS activation and NO production.
Pragmatic Information Processing Aspects of Graphically Accessed Computer-Aided Design

The specification of the pragmatic information content of graphical displays is approached by defining three display attributes¿ quantity, format, and time. A mathematical measure of pragmatic information quantity is proposed while the effects of format and time on pragmatic information processing activity are discussed qualitatively. An experimental evaluation of the effects of quantity, format, and timing of pragmatic information in a specially constructed graphically oriented design task is described.
Introducing PersPred, a Syntactic and Semantic Database for Persian Complex Predicates

This paper introduces PersPred, the first manually elaborated syntactic and semantic database for Persian Complex Predicates (CPs). Beside their theoretical interest, Persian CPs constitute an important challenge in Persian lexicography and for NLP. The first delivery, PersPred 1 1 , contains 700 CPs, for which 22 fields of lexical, syntactic and semantic information are encoded. The semantic classification PersPred provides allows to account for the productivity of these combinations in a way which does justice to their compositionality without overlooking their idiomaticity.
The biomechanics of situational baseball: Execution and perception of left-handed pitchers' simulated pick-off moves to first base

The aim of this study was to provide an in-depth analysis of the pick-off play in baseball. Ten collegiate left-handed pitchers and nine base-runners participated in this study. The pitchers were videotaped with four cameras to derive three-dimensional data while performing deliveries in the directions of first base and home plate in a laboratory setting. Deliveries were performed from flat ground. Differences between these deliveries were measured through ten selected joint and segment angles. The base-runners completed two distinct procedures in which they viewed video footage of left-handed pitchers and estimated the intended delivery direction. Base-runners were subsequently interviewed to determine the reasoning behind their decisions. The pitchers' data revealed differences between delivery types in nearly all of the selected angles (P < 0.01). The base-runners' data demonstrated that their ability to discriminate delivery types improved when allowed more viewing time per trial (P < 0.01). Additionally, commonalities exist among the base-runners' focal points on the pitcher while making decisions regarding delivery direction and the kinematic differences between deliveries in left-handed pitchers. The practical significance of these results, however, may be more difficult to interpret.
Career growth study: scale development and validity test

The study structures and tests a four-dimensional structure model of career growth, and develops a measurement scale of career growth. Based on the reviewing and generalizing of the correlated literature, it analyzes the links and differences between career growth and other related concepts. The original data is acquired through interviews and semi-structured questionnaire. By reference to the related research scales, the initial career growth scale is made through several steps, including cataloguing, summarizing and revising. The formal scale is constructed through the research methods of the items analysis, exploratory factor test and so forth. Confirmatory factor analysis approach is adopted to verify the four- dimensional structure model of career growth. The results indicate that career growth is a four-dimension concept, including career goal progress, professional ability development, promotion speed and remuneration growth. Two directions for the future researches of career growth theory are put forward.
On the Failure of Core Convergence in Economies with Asymmetric Information

In interim economies with asymmetric information, we show a robust failure of the core convergence theorem. We begin by showing that the coarse core of Wilson (1978) does not converge to any set of price equilibrium allocations considered in the literature. To prove our main point we construct a simple example of a replicated sunspot economy with strictly convex and monotonic preferences. We also show that the coarse core may not satisfy the equal treatment property. Moreover, coarse core allocations satisfying the equal treatment property may not converge to price equilibrium allocations. The result applies to any notion of price equilibrium (including rational expectations equilibria, Radner equilibria, sunspot equilibria) in which fully informed consumers receive a consumption plan maximizing ex-post utility over the ex-post budget set. The non-convergence result holds for several different notions of the interim core proposed in the literature, including the fine core (Wilson (1978)), the private core (Yannelis (1991)), the core in the pooling case (Ichiishi and Idzik (1996), Goenka and Shell (1997)), the incentive compatible core (Vohra (1999)), the coarse+ core (Lee and Volij (forthcoming)), the core with endogenous communication (Volij (forthcoming)). This failure of core convergence is a basic consequence of asymmetric information, which at the interim stage, imposes important restrictions on coalition formation. (Informational constraints may rule out many coalitions of types of consumers that would be present in the standard Debreu and Scarf (1963) complete information framework. ) In particular, our negative results do not rely on the lack of `informational smallness' of agents (at least in the sense in which this term has recently been formalized in McLean and Postlewaite (1999)).
VEGF Stimulates HDAC7 Phosphorylation and Cytoplasmic Accumulation Modulating Matrix Metalloproteinase Expression and Angiogenesis

Objective—Histone acetylation/deacetylation plays an important role in the control of gene expression, tissue growth, and development. In particular, histone deacetylases 7 (HDAC7), a member of class IIa HDACs, is crucial in maintaining vascular integrity. However, whether HDAC7 is involved in the processes of vascular endothelial signaling and angiogenesis remains unclear. Here, we investigated the role of HDAC7 in vascular endothelial growth factor (VEGF) signaling and angiogenesis. Methods and Results—We show for the first time that VEGF stimulated phosphorylation of HDAC7 at the sites of Ser178, Ser344, and Ser479 in a dose- and time-dependent manner, which leads to the cytoplasmic accumulation of HDAC7. Using pharmacological inhibitors, siRNA, and adenoviruses carrying dominant-negative mutants, we found that phospholipase Cγ/protein kinase C/protein kinase D1 (PKD1)-dependent signal pathway mediated HDAC7 phosphorylation and cytoplasmic accumulation by VEGF. Infection of ECs with adenoviruses encoding a mutant of HDAC7 specifically deficient in PKD1-dependent phosphorylation inhibited VEGF-induced angiogenic gene expression, including matrix metalloproteinases MT1-matrix metalloproteinase (MMP) and MMP10. Moreover, HDAC7 and its targeting genes were involved in VEGF-stimulated endothelial cell migration, tube formation, and microvessel sprouting. Conclusions—Our results demonstrate that VEGF stimulates PKD1-dependent HDAC7 phosphorylation and cytoplasmic accumulation in endothelial cells modulating gene expression and angiogenesis.
Role of Bile Acid-Regulated Nuclear Receptor FXR and G Protein-Coupled Receptor TGR5 in Regulation of Cardiorenal Syndrome (Cardiovascular Disease and Chronic Kidney Disease).

It is well known that chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease. In fact, studies have shown that cardiovascular event rates and all-cause mortality increase as a function of CKD as determined by decrease in estimated glomerular filtration rate and presence of microalbuminuria.1,2 In recent years, the term cardiorenal syndrome (CRS) has been proposed to define the relationship between cardiac disease and renal disease. Ronco et al has defined CRS as a pathophysiologic disorder of the heart and kidneys whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction in the other.3–6 CRS Type 1: acute CRS is defined as sudden worsening of cardiac function (acute cardiogenic shock or acutely decompensated heart failure), leading to acute kidney injury. CRS Type 2: chronic CRS is defined as chronic abnormalities in cardiac function (chronic congestive heart failure) causing progressive and potentially permanent CKD. CRS Type 3: acute renocardiac syndrome is defined as sudden worsening of kidney function (acute kidney injury or acute glomerulonephritis) causing acute cardiac disorder (heart failure, arrhythmia, or ischemia). CRS Type 4: chronic renocardiac syndrome is defined as CKD contributing to decreased cardiac function, cardiac hypertrophy, and increased risk of adverse cardiovascular events. CRS Type 5: secondary CRS is defined as systemic condition (obesity, diabetes mellitus, sepsis) causing simultaneous cardiac and renal dysfunction. In this review, I will be discussing mainly the type 5 CRS associated with obesity and diabetes mellitus and models of atherosclerosis and vascular calcification. In addition to discussing renal disease, I will also be discussing vascular disease because vascular dysfunction is a well-characterized complication of renal disease, and vascular dysfunction is also a leading cause of cardiac disease. Our work early on determined an important role for altered renal lipid …
Unexpected Relevance: An Empirical Study of Serendipity in Retweets

Serendipity is a beneficial discovery that happens in an unexpected way. It has been found spectacularly valuable in various contexts, including scientific discoveries, acquisition of business, and recommender systems. Although never formally proved with large-scale behavioral analysis, it is believed by scientists and practitioners that serendipity is an important factor of positive user experience and increased user engagement. In this paper, we take the initiative to study the ubiquitous occurrence of serendipitious information diffusion and its effect in the context of microblogging communities. We refer to serendipity as unexpected relevance, then propose a principled statistical method to test the unexpectedness and the relevance of information received by a microblogging user, which identifies a serendipitous diffusion of information to the user. Our findings based on large-scale behavioral analysis reveal that there is a surprisingly strong presence of serendipitous information diffusion in retweeting, which accounts for more than 25% of retweets in both Twitter and Weibo. Upon the identification of serendipity, we are able to conduct observational analysis that reveals the benefit of serendipity to microblogging users. Results show that both the discovery and provision of serendipity increase the level of user activities and social interactions, while the provision of serendipitous information also increases the influence of Twitter users.