Miracle-dz/UniFAR-FTUs huggingface dataset:
Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model of Myocardial Ischemia-Reperfusion Injury

Kaempferol (KMP), a dietary flavonoid, has antioxidant, anti-inflammatory, and antiapoptotic effects. Hence, we investigated the effect of KMP in ischemia-reperfusion (IR) model of myocardial injury in rats. We studied male albino Wistar rats that were divided into sham, IR-control, KMP-20 + IR, and KMP 20 per se groups. KMP (20 mg/kg; i.p.) was administered daily to rats for the period of 15 days, and, on the 15th day, ischemia was produced by one-stage ligation of left anterior descending coronary artery for 45 min followed by reperfusion for 60 min. After completion of surgery, rats were sacrificed; heart was removed and processed for biochemical, morphological, and molecular studies. KMP pretreatment significantly ameliorated IR injury by maintaining cardiac function, normalizing oxidative stress, and preserving morphological alterations. Furthermore, there was a decrease in the level of inflammatory markers (TNF-α, IL-6, and NFκB), inhibition of active JNK and p38 proteins, and activation of ERK1/ERK2, a prosurvival kinase. Additionally, it also attenuated apoptosis by reducing the expression of proapoptotic proteins (Bax and Caspase-3), TUNEL positive cells, and increased level of antiapoptotic proteins (Bcl-2). In conclusion, KMP protected against IR injury by attenuating inflammation and apoptosis through the modulation of MAPK pathway.
Tying Odysseus to the Mast: Evidence from a Commitment Savings Product in the Philippines

We designed a commitment savings product for a Philippine bank and implemented it using a randomized control methodology. The savings product was intended for individuals who want to commit now to restrict access to their savings, and who were sophisticated enough to engage in such a mechanism. We conducted a baseline survey on 1777 existing or former clients of a bank. One month later, we offered the commitment product to a randomly chosen subset of 710 clients; 202 (28.4 percent) accepted the offer and opened the account. In the baseline survey, we asked hypothetical time discounting questions. Women who exhibited a lower discount rate for future relative to current tradeoffs, and hence potentially have a preference for commitment, were indeed significantly more likely to open the commitment savings account. After twelve months, average savings balances increased by 81 percentage points for those clients assigned to the treatment group relative to those assigned to the control group. We conclude that the savings response represents a lasting change in savings, and not merely a short-term response to a new product.
Equivalence results in the allocation of indivisible objects : A unified view

This paper studies probabilistic mechanisms that allocate indivisible objects to agents by hierarchical exchange using the top-trading cycles algorithm. The main result of this paper is a general technique for proving that seemingly different probabilistic mechanisms are in fact equivalent. This approach simplifies and unifies several equivalence results in the literature. The same technique is used to generalize these results to mechanisms in which the priority structure for each object is given by a tree (instead of a linear ordering of the agents).
Geographic smoothing of solar PV: results from Gujarat

We examine the potential for geographic smoothing of solar photovoltaic (PV) electricity generation using 13 months of observed power production from utility-scale plants in Gujarat, India. To our knowledge, this is the first published analysis of geographic smoothing of solar PV using actual generation data at high time resolution from utility-scale solar PV plants. We use geographic correlation and Fourier transform estimates of the power spectral density (PSD) to characterize the observed variability of operating solar PV plants as a function of time scale. Most plants show a spectrum that is linear in the log–log domain at high frequencies f, ranging from f − 1.23 ? > to f − 1.56 ? > (slopes of −1.23 and −1.56), thus exhibiting more relative variability at high frequencies than exhibited by wind plants. PSDs for large PV plants have a steeper slope than those for small plants, hence more smoothing at short time scales. Interconnecting 20 Gujarat plants yields a f − 1.66 ? > spectrum, reducing fluctuations at frequencies corresponding to 6 h and 1 h by 23% and 45%, respectively. Half of this smoothing can be obtained through connecting 4–5 plants; reaching marginal improvement of 1% per added plant occurs at 12–14 plants. The largest plant (322 MW) showed an f − 1.76 ? > spectrum. This suggests that in Gujarat the potential for smoothing is limited to that obtained by one large plant.
The Impact of Training Data on Automated Short Answer Scoring Performance

Automatic evaluation of written responses to content-focused assessment items (automated short answer scoring) is a challenging educational application of natural language processing. It is often addressed using supervised machine learning by estimating models to predict human scores from detailed linguistic features such as wordn-grams. However, training data (i.e., human-scored responses) can be difficult to acquire. In this paper, we conduct experiments using scored responses to 44 prompts from 5 diverse datasets in order to better understand how training set size and other factors relate to system performance. We believe this will help future researchers and practitioners working on short answer scoring to answer practically important questions such as, “How much training data do I need? ”
Structure and Function of Human Prepro-orexin Gene*

Orexin-A and -B are recently identified potent orexigenic peptides that are derived from the same precursor peptide and are highly specifically localized in neurons located in the lateral hypothalamic area, a region classically implicated in feeding behavior. We cloned the whole length of the human prepro-orexin gene and corresponding cDNA. The human prepro-orexin mRNA was predicted to encode a 131-residue precursor peptide (prepro-orexin). The human prepro-orexin gene consists of two exons and one intron distributed over 1432 base pairs. The 143-base pair first exon includes the 5′-untranslated region and a small part of the coding region that encodes the first seven residues of the secretory signal sequence. The second exon contains the remaining portion of the open reading frame and 3′-untranslated region. The 3.2 kilobase pairs of the 5′-upstream region from a cloned human prepro-orexin gene promoter is sufficient to direct the expression of the Escherichia coliβ-galactosidase (lacZ) gene in transgenic mice to neurons in the lateral hypothalamic area and adjacent regions. ThelacZ-positive neurons were positively stained with anti-orexin antibody but not with anti-melanin-concentrating hormone antibody. These findings suggest that this genomic fragment contains all the necessary elements for appropriate expression of the gene and will be useful for the targeted expression of the exogenous gene in orexin-containing neurons. These mice might also be useful for examining the molecular mechanisms by which orexin gene expression is regulated.
A Novel Mouse Model of Penetrating Brain Injury

Penetrating traumatic brain injury (pTBI) has been difficult to model in small laboratory animals, such as rats or mice. Previously, we have established a non-fatal, rat model for pTBI using a modified air-rifle that accelerates a pellet, which hits a small probe that then penetrates the experimental animal’s brain. Knockout and transgenic strains of mice offer attractive tools to study biological reactions induced by TBI. Hence, in the present study, we adapted and modified our model to be used with mice. The technical characterization of the impact device included depth and speed of impact, as well as dimensions of the temporary cavity formed in a brain surrogate material after impact. Biologically, we have focused on three distinct levels of severity (mild, moderate, and severe), and characterized the acute phase response to injury in terms of tissue destruction, neural degeneration, and gliosis. Functional outcome was assessed by measuring bodyweight and motor performance on rotarod. The results showed that this model is capable of reproducing major morphological and neurological changes of pTBI; as such, we recommend its utilization in research studies aiming to unravel the biological events underlying injury and regeneration after pTBI.
Scalable and portable web-based multimodal dialogue interaction with geographical databases

We describe work towards developing a scalable and portable framework for enabling map-based multimodal dialogue interaction over the web. Working in the context of a restaurant-guide system, we show how large information databases harvested from the web can be accommodated in our speech recognizer, parser, and web-based GUI. We compare two dynamic language modeling techniques, which calculate context-dependent weights for the large sets of proper nouns associated with geographical entities such as restaurants and streets. We show that the more fine-grained approach results in a 7.8% reduction in concept error rate. Index Terms: multimodal dialogue system, language modeling, restaurants, maps, world wide web
Surveillance for severe community-associated methicillin-resistant Staphylococcus aureus infection

SUMMARY Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has rapidly emerged in the USA as a cause of severe infections in previously healthy persons without traditional risk factors. We describe the epidemiology of severe CA-MRSA disease in the state of Georgia, USA and analyse the risk of death associated with three different clinical syndromes of CA-MRSA disease – pneumonia, invasive disease, and skin and soft-tissue infections (SSTIs). A total of 1670 cases of severe CA-MRSA disease were reported during 2005–2007. The case-fatality rate was 3·4%; sex and race of fatal and non-fatal cases did not differ significantly. While CA-MRSA pneumonia and invasive disease were less common than SSTIs, they were about 15 times more likely to result in death [risk ratio 16·69, 95% confidence interval (CI) 10·28–27·07 and 13·98, 95% CI 7·74–25·27, respectively]. When controlling for age and the presence of other clinical syndromes the odds of death in patients manifesting specific severe CA-MRSA syndromes was highest in those with pneumonia (odds ratio 11·34). Possible risk factors for severe CA-MRSA SSTI and pneumonia included the draining of lesions without medical assistance and an antecedent influenza-like illness.
Vertically uniform formation pathways of tropospheric sulfate aerosols in East China detected from triple stable oxygen and radiogenic sulfur isotopes

Sulfate aerosols (SO42−) in the continental outflow from East China significantly alter the atmospheric sulfur budget across the Pacific Rim, but its formation pathways, especially in the free troposphere (FT), remain poorly understood. Here we analyze stable oxygen (δ17O and δ18O) and radiogenic sulfur (35S) isotopes in SO42− collected at a mountain site in East China to investigate SO42− formation pathways at varying altitudes. We find that Δ17O (=δ17O‐0.52 × δ18O) in SO42− is not correlated with 35S (a direct measure of high‐altitude air masses). This pattern notably differs from the currently known 35S‐Δ17O relation. The result implies that the formation pathway of tropospheric SO42− in East China is vertically uniform, likely due to large emissions and active convection in this region. Our measurements provide unambiguous isotopic constraints for reducing uncertainties in modeling SO42− in the FT over East China, which greatly affects regional climate but current models fail to accurately estimate.
Intramuscular injections of male pheromone 5 alpha-androstenol change the secretory ovarian function in gilts during sexual maturation.

In addition to the standard olfactory pathway typical for signaling pheromones, the existence of a humoral pathway for the priming action of pheromones has been earlier postulated. In this study in vivo experiment was performed to establish whether intramuscular injections of boar pheromone, 5 alpha-androstenol (5 alpha-androst-16-en-3-ol), might change the development and secretory function of the ovarian follicles during sexual maturation of gilts. Gilts from groups I (n=15) and II (n=13) received androstenol (10 microg/gilt/injection; i.m.) three times a week from day 192 to 234 of age. Similar, control gilts (group C; n=13) received saline. Additionally, the nasal cavity of animals from group II was irrigated with zinc sulfate solution to depress olfactory function. The reproductive organs and follicular fluid were collected on day 240 of age. There were no significant differences among groups concerning the weight of the ovary and uterus, the length of the uterine horns and intensity of cytochrome P450(scc) and P450(arom) immunoexpression. However, gilts treated with boar pheromone had a higher (p<0.01) total number of follicles > 3 mm in diameter and a lower index of atresia. In addition, androstenol-treated animals were characterized by higher concentrations of progesterone (the 1-3 mm and 3-6 mm follicles; p<0.01 and 0.001, respectively) and estradiol (follicles 3-6 mm; p<0.001) than those of controls. The results of the present study demonstrate that intramuscular injections of androstenol stimulate the development and secretory function of the ovarian follicles in gilts during sexual maturation. They also support the hypothesis that androstenol, as a priming boar pheromone, may influence reproductive processes in female pigs acting as a chemical signal via humoral pathway.
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network

Forming distinct representations of multiple contexts, places, and episodes is a crucial function of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells. The mutant mice performed normally in contextual fear conditioning, but were impaired in the ability to distinguish two similar contexts. A significant reduction in the context-specific modulation of firing rate was observed in the CA3 pyramidal cells when the mutant mice were transferred from one context to another. These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation.
Epidemiology of chronic obstructive pulmonary disease: a literature review

The aim of this study is to quantify the burden of chronic obstructive pulmonary disease (COPD) – incidence, prevalence, and mortality – and identify trends in Australia, Canada, France, Germany, Italy, Japan, The Netherlands, Spain, Sweden, the United Kingdom, and the United States of America. A structured literature search was performed (January 2000 to September 2010) of PubMed and EMBASE, identifying English-language articles reporting COPD prevalence, incidence, or mortality. Of 2838 articles identified, 299 full-text articles were reviewed, and data were extracted from 133 publications. Prevalence data were extracted from 80 articles, incidence data from 15 articles, and mortality data from 58 articles. Prevalence ranged from 0.2%–37%, but varied widely across countries and populations, and by COPD diagnosis and classification methods. Prevalence and incidence were greatest in men and those aged 75 years and older. Mortality ranged from 3–111 deaths per 100,000 population. Mortality increased in the last 30–40 years; more recently, mortality decreased in men in several countries, while increasing or stabilizing in women. Although COPD mortality increased over time, rates declined more recently, likely indicating improvements in COPD management. In many countries, COPD mortality has increased in women but decreased in men. This may be explained by differences in smoking patterns and a greater vulnerability in women to the adverse effects of smoking.
The cardiotomy reservoir – a preliminary evaluation of a new cell source for cardiovascular tissue engineering

Objectives: Cell sources for cardiovascular tissue engineering (TE) are scant. However, the need for an ideal TE cardiovascular implant persists. We investigated the cardiotomy reservoir (CR) as a potential cell source that is more accessible and less ethically problematic. Methods: CR (n = 10) were removed from the bypass system after surgery. Isolation was performed using different isolation methods: blood samples were taken from the cardiopulmonary bypass and centrifuged at low density. The venous filter screen was cut out and placed into petri dishes for cultivation. The spongelike filter was removed, washed and treated in the same way as the blood samples. After cultivation, cell lines of fibroblasts (FB) and endothelial cells (EC) were obtained for analysis. The cells were seeded on polyurethane patches and analyzed via scanning electron microscopy (SEM), Life/Dead assay and immunohistochemistry. Results: No correlation between age, time of surgery and quality of cells was observed. The successful extraction of FB and was proven by positive staining results for TE-7, CD31 and vWF. Cell morphology, cytoskeleton staining and quantification of proliferation using WST-1 assay resembled the cells of the control group in all ways. The topography of a confluent and vital cell layer after cell seeding was displayed by SEM analysis, Life/Dead Assay and immunohistochemistry. The establishment of an extracellular matrix (ECM) was proven by positive staining for collagen IV, laminin, fibronectin and elastin. Conclusions: Viable FB and EC cell lines were extracted from the CR after surgery. Easy access and high availability make this cell source destined for widespread application in cardiovascular tissue engineering.
The chemistry of the early Universe

The process of molecule formation in the primor- dial gas is considered in the framework of Friedmann cosmo- logical models from redshift z =1 0 4 to z =0 . First, a com- prehensive analysis of 87 gas phase reaction rates (both col- lisional and radiative) relevant in the physical environment of the expanding universe is presented and critically discussed. On this basis, calculations are carried out of the abundance of 21 molecular species as function of redshift, for different values of the cosmological parameters 0, and H0, evaluating con- sistently the molecular heating and cooling due to H2 ,H D and LiH molecules. One of the major improvements of this work is the use of a better treatment of H recombination that leads to a reduction of a factor 2-3 in the abundance of electrons and H + at freeze-out, with respect to previous studies. The lower residual ionization has a negative effect on the chemistry of the primordial gas in which electrons and protons act as cat- alysts in the formation of the first molecules. We find that in the standard model (h =0 :67, 10 =4 :5, 0 =1 and (D/H) =4 :3 10 5 ), the residual fractional ionization at z =1 is (e= H) =3 :0210 4 , and the main molecular species fractional abundances (H2= H) =1 :1 10 6 , (HD=H 2 )=1 :1 10 3 , (HeH + = H) =6 :2 10 13 , (LiH + = H) =9 :4 10 18 and (LiH=LiH + )=7 :6 10 3 . We devise a reduced chemical network that reproduces with excellent accuracy the numerical results of the complete model and allows to follow the chemical compositions and the thermal properties of a primordial gas in the presence of an external radiation field. Finally, we provide accurate cooling functions of H2, HD and LiH in a wide range of density and temperature that can be conveniently used in a variety of cosmological applications.
Robust hand gesture recognition based on finger-earth mover's distance with a commodity depth camera

The recently developed depth sensors, e.g., the Kinect sensor, have provided new opportunities for human-computer interaction (HCI). Although great progress has been made by leveraging the Kinect sensor, e.g. in human body tracking and body gesture recognition, robust hand gesture recognition remains an open problem. Compared to the entire human body, the hand is a smaller object with more complex articulations and more easily affected by segmentation errors. It is thus a very challenging problem to recognize hand gestures. This paper focuses on building a robust hand gesture recognition system using the Kinect sensor. To handle the noisy hand shape obtained from the Kinect sensor, we propose a novel distance metric for hand dissimilarity measure, called Finger-Earth Mover's Distance (FEMD). As it only matches fingers while not the whole hand shape, it can better distinguish hand gestures of slight differences. The extensive experiments demonstrate the accuracy, efficiency, and robustness of our hand gesture recognition system.
Can sheared surfaces emit light

Abstract We apply a new formalism to calculating emission of light from sheared dielectric surfaces. When the surfaces are smooth, the emission of light requires extreme velocities, but introducing surface roughness with short-period components reduces the extreme demands on velocity so that, for atomic-scale roughness, shear velocities as small as 104 ms−1 will result in light emission. Some order-of-magnitude estimates are given.
A prospective open-label study of glatiramer acetate: over a decade of continuous use in multiple sclerosis patients

A decade of continuous glatiramer acetate (GA) use by relapsing remitting multiple sclerosis (RRMS) patients was evaluated in this ongoing, prospective study, and the neurological status of ‘Withdrawn’ patients was assessed at a 10-year long-term follow-up (LTFU) visit. Modified intention-to-treat (mITT, n=232) patients received ≥ 1 GA dose since 1991; ‘Ongoing’ patients (n=108) continued in November 2003. Of 124 patients, 50 Withdrawn patients returned for LTFU. Patients were evaluated every six months (EDSS). Mean GA exposure was 6.99, 10.1 and 4.26 years for mITT, Ongoing, and Withdrawn/LTFU patients, respectively. While on GA, mITT relapse rates declined from 1.18/year prestudy to ∼1 relapse/5 years; median time to ≥ 1 EDSS point increase was 8.8 years; mean EDSS change was 0.739±1.66 points; 58% had stable/improved EDSS scores; and 24, 11 and 3% reached EDSS 4, 6 and 8, respectively. For Ongoing patients, EDSS increased 0.509±1.65; 62% were stable/improved; and 24, 8 and 1% reached EDSS 4, 6 and 8, respectively. For Withdrawn patients at 10-year LTFU, EDSS increased 2.249±1.86; 28% were stable/improved; and 68, 50 and 10% reached EDSS 4, 6 and 8, respectively. While on GA nearly all patients (mean disease duration 15 years) remained ambulatory. At LTFU, Withdrawn patients had greater disability than Ongoing patients.