Miracle-dz/UniFAR-FTUs huggingface dataset:
An In Vitro Potency Assay for Monitoring the Immunomodulatory Potential of Stromal Cell-Derived Extracellular Vesicles

The regenerative and immunomodulatory activity of mesenchymal stromal cells (MSCs) is partially mediated by secreted vesicular factors. Extracellular vesicles (EVs) exocytosed by MSCs are gaining increased attention as prospective non-cellular therapeutics for a variety of diseases. However, the lack of suitable in vitro assays to monitor the therapeutic potential of EVs currently restricts their application in clinical studies. We have evaluated a dual in vitro immunomodulation potency assay that reproducibly reports the inhibitory effect of MSCs on induced T-cell proliferation and the alloantigen-driven mixed leukocyte reaction of pooled peripheral blood mononuclear cells in a dose-dependent manner. Phytohemagglutinin-stimulated T-cell proliferation was inhibited by MSC-derived EVs in a dose-dependent manner comparable to MSCs. In contrast, inhibition of alloantigen-driven mixed leukocyte reaction was only observed for MSCs, but not for EVs. Our results support the application of a cell-based in vitro potency assay for reproducibly determining the immunomodulatory potential of EVs. Validation of this assay can help establish reliable release criteria for EVs for future clinical studies.
Effect of liming on nickel bioavailability and toxicity to oat and soybean grown in field soils containing aged emissions from a nickel refinery

Remediation of soils elevated in trace metals so that the soils may provide ecosystems services is typically achieved through pH adjustment or addition of sorbents. The present study aimed to generate higher‐tier in situ toxicity data for elevated nickel (Ni) in soils with and without lime addition and to explore the effect of liming on soil chemistry and bioavailability of Ni to plants. A multiyear study of agronomic yield of field‐grown oat and soybean occurred in 3 adjacent fields that had received air emissions from a Ni refinery for 66 yr. The soil Ni concentration in the plots ranged between 1300 mg/kg and 4900 mg/kg, and each field was amended with either 50 Mg/ha, 10 Mg/ha, or 0 Mg/ha (or tonnes/ha) of crushed dolomitic limestone. As expected, liming raised the pH of the soils and subsequently reduced the plant availability of Ni. Toxicity thresholds (effective concentrations causing 50% reduction in growth) for limed soils supported the hypothesis that liming reduces toxicity. Relationships were found between relative yield and soil cation exchange capacity and between relative yield and soil pH, corroborating findings of the European Union Risk Assessments and the Metals in Asia studies, respectively. Higher tier ecotoxicity data such as these are a valuable contribution to risk assessment for Ni in soils. Environ Toxicol Chem 2017;36:1110–1119. © 2016 SETAC
Colorant-free coloration and superhydrophilic modification of poly(ethylene terephthalate) fabric surface by H2O2 and nano-TiO2 ultraviolet photocatalysis

In the paper, synchronous colorant-free coloration and superhydrophilic modification of poly(ethylene terephthalate) (PET) fabric surface were successfully investigated. PET fabric surface treated by nano-TiO2-H2O2/ultraviolet light becomes both a brilliant kelly with a color strength (K/S) value of 3.0147 and superhydrophilic with a water contact angle of 0° in a short time. The coloration parameters were optimized and PET fabric can be uniformly colored without colorant used. The wash fastness, rub fastness and light fastness of treated PET fabric were similar to the control PET fabric. The mechanical properties of modified PET fabric were hardly affected. The chemical structure of modified PET surface was investigated by X-ray photoelectron spectroscopy (XPS) and attenuated total reflectance Fourier transform infrared spectra, demonstrating –COOH, >C = O, −NO and –NO2 new groups. The mechanisms of coloration and superhydrophilic modification of PET surface were proposed. Scanning electron microscopy images showed that new materials were formed on the surface of modified PET fibers. X-ray diffraction and thermogravimetric analysis indicated that the crystallinity increased a little and the thermal stability of modified PET fibers clearly increased. This novel method exhibited highly efficient and eco-friendly advantages for both coloration and superhydrophilic modification of PET fabric surface.
Simple and aneurysmal bone cyst: Aspects of jaw pseudocysts based on an experience of Brazilian pathology service during 53 years

Background Jaw pseudocysts are benign osseous lesions of unclear etiology. Among these, the simple bone cyst (SBC) and aneurysmal bone cyst (ABC) are intriguing bone pathologies still rarely studied together. This retrospective study aimed to present the long-term case series of patients with jaw pseudocysts focusing on the clinical, radiographic, and transoperative aspects. Material and Methods A retrospective case series of patients with SBC and ABC was performed. Clinical, radiographic, and transoperative aspects of both pseudocysts were reviewed from the histopathological archives of 20,469 cases between 1959-2012. All descriptive data were summarized. Results Of 354 (15.25%) bone pathologies, 54 cases of jaw pseudocysts were found, with 42 (11.86%) SBC and 12 (3.39%) ABC cases. For both lesions, most of the sample were young Caucasian women with an asymptomatic posterior mandible lesion with undetermined time of evolution and none trauma history. A unique radiolucent scalloped lesion presenting an empty cavity were also observed for both conditions. However, some atypical findings were found for SBC including: the expansion of bone cortical, tooth resorption, displacement of the mandibular canal, and recurrence. The absence of painful symptoms and the lack of classical blood-filled cavity were observed in some cases of ABC. Conclusions The SBC and ABC are bone pathologies with few retrospective studies, no previous studies on the two conditions, varied nomenclature, and atypical aspects in some cases. Therefore, the knowledge of clinical, imaging, and transoperative features of such pseudocysts are clinically valuable as diagnosis hypothesis of radiolucent lesions of the jaws. Key words:Simple bone cyst, aneurysmal bone cyst, pseudocysts, jaws.
Rituximab as first-line treatment for acquired thrombotic thrombocytopenic purpura

Objective To investigate the efficacy and safety of rituximab (RTX) as first-line treatment of acquired thrombotic thrombocytopenic purpura (aTTP). Methods Twenty-five patients with acute aTTP and/or severe a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) deficiency were admitted to our centre from April 2009 to March 2015. Fourteen patients received RTX plus standard therapy (plasma exchange and corticosteroids) at acute episodes. Haemoglobin, platelet count, schistocytes, lactate dehydrogenase levels, ADAMTS13 activity and its inhibitors, and the ratio of B lymphocytes in the peripheral blood, were monitored. The number of plasma exchange (PEXs), total plasma volume, remission time, relapse ratio, and adverse effects were recorded. Results The median number of PEXs was 5 (2–17) sessions and median total plasma volume was 168.43 ml/kg (62.86–469.52 ml/kg). Patients achieved haematological remission at a median of 15 days (5–22 days), and the median time of immunological remission was 2 weeks (2–8 weeks) with a median follow-up of 13 months (3–61 months). ADAMTS13 activity significantly increased after 2 weeks. The B lymphocyte percentage in peripheral blood was reduced 1 week after the first dose of RTX infusion compared with before treatment (2.21% ± 5.23% vs 18.47% ± 7.34%, P = 0.000 [the result of statistical software]), and began to gradually increase 9 months later. Severe adverse effects and relapsing TTP were not observed during therapy and follow-up. However, one patient who had sustained immunological remission died of severe pneumonia 7 months later. Conclusion Although our study was limited by its small sample number and it was a non-controlled, clinical trial, it showed potential benefits of RTX therapy for acute aTTP. RTX may be administered as a first-line therapy for lowering patients’ relapse rate in the long term. Randomized, controlled trials of RTX for aTTP are required.
Certainty in Heisenberg’s Uncertainty Principle: Revisiting Definitions for Estimation Errors and Disturbance

We revisit the definitions of error and disturbance recently used in error-disturbance inequalities derived by Ozawa and others by expressing them in the reduced system space. The interpretation of the definitions as mean-squared deviations relies on an implicit assumption that is generally incompatible with the Bell-Kochen-Specker-Spekkens contextuality theorems, and which results in averaging the deviations over a non-positive-semidefinite joint quasiprobability distribution. For unbiased measurements, the error admits a concrete interpretation as the dispersion in the estimation of the mean induced by the measurement ambiguity. We demonstrate how to directly measure not only this dispersion but also every observable moment with the same experimental data, and thus demonstrate that perfect distributional estimations can have nonzero error according to this measure. We conclude that the inequalities using these definitions do not capture the spirit of Heisenberg's eponymous inequality, but do indicate a qualitatively different relationship between dispersion and disturbance that is appropriate for ensembles being probed by all outcomes of an apparatus. To reconnect with the discussion of Heisenberg, we suggest alternative definitions of error and disturbance that are intrinsic to a single apparatus outcome. These definitions naturally involve the retrodictive and interdictive states for that outcome, and produce complementarity and error-disturbance inequalities that have the same form as the traditional Heisenberg relation.
Complex observation of scalp fast (40–150 Hz) oscillations in West syndrome and related disorders with structural brain pathology

We investigated the relationship between the scalp distribution of fast (40–150 Hz) oscillations (FOs) and epileptogenic lesions in West syndrome (WS) and related disorders. Subjects were 9 pediatric patients with surgically confirmed structural epileptogenic pathology (age at initial electroencephalogram [EEG] recording: mean 7.1 months, range 1–22 months). The diagnosis was WS in 7 patients, Ohtahara syndrome in 1, and a transitional state from Ohtahara syndrome to WS in the other. In the scalp EEG data of these patients, we conservatively detected FOs, and then examined the distribution of FOs. In five patients, the scalp distribution of FOs was consistent and concordant with the lateralization of cerebral pathology. In another patient, FOs were consistently dominant over the healthy cerebral hemisphere, and the EEG was relatively low in amplitude over the pathological atrophic hemisphere. In the remaining 3 patients, the dominance of FOs was inconsistent and, in 2 of these patients, the epileptogenic hemisphere was reduced in volume, which may result from atrophy or hypoplasia. The correspondence between the scalp distribution of FOs and the epileptogenic lesion should be studied, taking the type of lesion into account. The factors affecting scalp FOs remain to be elucidated.
Fine-Grained Retrieval with Autoencoders

In this paper we develop a representation for fine-grained retrieval. Given a query, we want to retrieve data items of the same class, and, in addition, rank these items according to intra-class similarity. In our training data we assume partial knowledge: class labels are available, but the intra-class attributes are not. To compensate for this knowledge gap we propose using an autoencoder, which can be trained to produce features both with and without labels. Our main hypothesis is that network architectures that incorporate an autoencoder can learn features that meaningfully cluster data based on the intra-class variability. We propose and compare different architectures to construct our features, including a Siamese autoencoder (SAE), a classifying autoencoder (CAE) and a separate classifier-autoencoder (SCA). We find that these architectures indeed improve fine grained retrieval compared to features trained purely in a supervised fashion for classification. We perform experiments on four datasets, and observe that the SCA generally outperforms the other two. In particular, we obtain state of the art performance on fine-grained sketch retrieval.
Prevalence of adult overweight and obesity in 20 European countries, 2014

Background Monitoring obesity and overweight prevalence is important for assessing interventions aimed at preventing or reducing the burden of obesity. This study aimed to provide current data regarding the prevalence of overweight and obesity of adults, from 20 European countries. Methods Participants were 34 814 (16 482 men) adults with mean age 50.8 ± 17.7. Data from European Social Survey round 7, 2014, were analysed. Body mass index (BMI) was calculated from self-reported height and weight. Results The proportion of underweight was only 2%, and 44.9% for normal weight. Overweight and obese accounted for 53.1%. More men than women were overweight (44.7% vs. 30.5%). Older adults were significantly more overweight (42.4%) and obese (20.9%) than middle age and younger adults. Retired people account for a greater proportion of overweight (42.0%) and obese (21.5%), when compared with employed, unemployed and students. People from rural areas were significantly more overweight (39.1 vs. 36.1%) and obese (17.0 vs. 15.3%) than those who lived in urban areas. The estimates indicate that the highest prevalence of overweight was in Czech Republic (45.2%), Hungary (43.7%) and Lithuania (41.7%). For obesity, Slovenia (20.8%), Estonia (19.7%) and the United Kingdom (19.2%) were the countries with the highest prevalence. Conclusion Even though data was self-reported, and individuals tend to overestimate their height and underestimate their weight, the prevalence of overweight and obesity is considered high. More than half of the European population is overweight and obese. This study strengthens and updates the claims of an excessive weight epidemic in Europe.
Kinetics, Mechanism and Theoretical Studies of Norbornene-Ethylene Alternating Copolymerization Catalyzed by Organopalladium(II) Complexes Bearing Hemilabile α-Amino–pyridine

Cationic methylpalladium complexes bearing hemilabile bidentate α-amino–pyridines can serve as effective precursors for catalytic alternating copolymerization of norbornene (N) and ethylene (E), under mild conditions. The norbornyl palladium complexes in the formula of {[RHNCH2(o-C6H4N)]Pd(C7H10Me)(NCMe)}(BF4) (R = iPr (2a), tBu (2b), Ph (2c), 2,6-Me2C6H3 (2d), 2,6-iPr2C6H3 (2e)) were synthesized via single insertion of norbornene into the corresponding methylpalladium complexes 1a–1e, respectively. Both square planar methyl and norbornyl palladium complexes exhibit facile equilibria of geometrical isomerization, via sterically-controlled amino decoordination–recoordination of amino–pyridine. Kinetic studies of E-insertion, N-insertion of complexes 1 and 2, and the geometric isomerization reactions have been examined by means of VT-NMR, and found in excellent agreement with the results estimated by DFT calculations. The more facile N-insertion in the cis-isomers, and ready geometric isomerization, cooperatively lead to a new mechanism that accounts for the novel catalytic formation of alternating COC.
Creatine kinase rate constant in the human heart measured with 3D‐localization at 7 tesla

We present a new Bloch‐Siegert four Angle Saturation Transfer (BOAST) method for measuring the creatine kinase (CK) first‐order effective rate constant kf in human myocardium at 7 tesla (T). BOAST combines a variant of the four‐angle saturation transfer (FAST) method using amplitude‐modulated radiofrequency pulses, phosphorus Bloch‐Siegert B1+ ‐mapping to determine the per‐voxel flip angles, and nonlinear fitting to Bloch simulations for postprocessing.
The Assessment of Pain in Older People: UK National Guidelines

We are facing a huge increase in the older population over the next 30 years. This brings an anticipated increase in the prevalence of chronic pain and with this comes the challenge of assessment of pain in many varied settings. Our first iteration of this document was published in 2007. But there has been a proliferation of literature and research since then, so we have developed a new set of guidelines. Different patterns and sites of pain were seen in men and women. Age differences suggest that pain prevalence increased with age up to 85 years and then decreased. The available studies on barriers and attitudes to pain management point towards an adherence to bio-medically orientated beliefs about pain, concern amongst clinicians in relation to activity recommendations, and a negative orientation in general towards patients with chronic painful conditions. A multidisciplinary approach to the assessment and treatment of pain is essential, but the assessment is a complex process which is hampered by many communication issues, including cognitive ability and socio-cultural factors. Such issues are part of the UK ageing population. Structured pain education should be implemented that provides all health professionals (whether professionally or non-professionally trained) with standardised education and training in the assessment and management of pain according to level of experience. Although subjective, patient self-report is the most valid and reliable indicator of pain and it may be necessary to ask questions about pain in different ways in order to elicit a response. A number of valid and reliable self-report measures are available and can be used even when moderate dementia exists. The Numerical Rating Scale or verbal descriptors can be used with people who have mild to moderate cognitive impairment. For people with severe cognitive impairment Pain in Advanced Dementia (PAINAD) and Doloplus-2 are recommended. PAINAD and Doloplus-2 scales continue to show positive results in terms of reliability and validity. There has been no recent evaluation of the Abbey pain scale although it is widely used throughout the UK. There is a need for more research into pain assessment using the collaborative role of the multidisciplinary team in all care settings. Self-report questionnaires of function are limited in their ability to capture the fluctuations in capacity and ability. The concentration on items of relevance to the population of interest means that issues of personal relevance can be obscured. Strong associations were seen between pain and depressed mood with each being a risk factor for the other. Additionally, loneliness and social isolation were associated with an increased risk of pain. Clinicians should be cognisant that social isolation and or depressive signs and symptoms may be indicators of pre-existing pain or a predictor of future pain onset. There are a number of evidence based guidelines on pain assessment in older people with or without cognitive impairment from around the world, including Australia and Europe.
Statins for the prevention of contrast-induced acute kidney injury

Purpose of reviewTo highlight the most recently published meta-analyses on the role of statins in the prevention of contrast-induced acute kidney injury (CI-AKI) and to formulate recommendations for clinical practice. Recent findingsNine meta-analyses were published on this topic from January 2015 to April 2016. Significant clinical heterogeneity between studies, regarding study population, treatment protocol, concomitant preventive strategies or dosage and duration of statin therapy was observed. In addition, the definition of CI-AKI was not uniform throughout all studies, and a number of other clinically meaningful endpoints, such as length of hospital stay in patients who developed CI-AKI, as well as adverse events, were rarely analyzed. SummaryDespite some promising results, it is premature to adapt the existing guidelines and implement the preprocedural use of statins in daily clinical practice. At present, low volumes of iso-osmolar or low-osmolar intravascular contrast and adequate intravascular hydration in high-risk patients remain the cornerstone for the prevention of CI-AKI. There is a need for additional well designed randomized controlled trials to clarify these issues and assess the risk vs benefit of statin use for the purpose of CI-AKI prevention.
Laser Shock Peening for Fatigue Resistance

Laser shock peening is developing into a commercial surface enhancement process for increasing the fatigue life of metal components. The process produces deep residual compressive stresses into treated surfaces which inhibit the initiation and propagation of fatigue cracks. The process has been particularly effective in increasing the resistance to foreign object damage in fan and compressor blades of aircraft gas turbine engines. However, the potential application of this process is much broader, encompassing automotive, tooling and dies, and others. Significant effort is being made to lower the cost and increase the throughput of the process, to make it an affordable process for many more applications. This describes the process and reviews the progress being made in the technology, both in material property enhancement and use of the process, and towards reducing cost and increasing throughput.
Starvation promotes odor/feeding-time associations in flies

Starvation causes a motivational state that facilitates diverse behaviors such as feeding, walking, and search. Starved Drosophila can form odor/feeding-time associations but the role of starvation in encoding of “time” is poorly understood. Here we show that the extent of starvation is correlated with the fly's ability to establish odor/feeding-time memories. Prolonged starvation promotes odor/feeding-time associations after just a single cycle of reciprocal training. We also show that starvation is required for acquisition but is dispensable for retrieval of odor/feeding-time memory. Finally, even with extended starvation, a functional circadian oscillator is indispensable for establishing odor/feeding-time memories.
The Effect of Wearing Denture and Changes of Occlusal Position on Body Sway in Edentulous Patient.

To clarify the correlation between the changes in the status of the occlusion system and the systemic posture, an investigation of the states of denture wearing in edentulous and changes in their body sways associated with occlusal support was made, focusing on the postural reflex. Body sway was assessed under four conditions: during clenching, centric occlusion, the rest position wearing upper and lower dentures and during the rest position with no dentures. The following results were obtained:1. The standard deviation in the X component (right-left direction) of body sway was significantly larger during the rest position without dentures than during either of the rest position, centric occlusion, or clenching with dentures.2. The differences in the standard deviations in the Y component (anterior-posterior direction) were not significant among the above four conditions.3. The distance of body sway during the rest position with dentures was significantly larger than any distance during centric occlusion or clenching with dentures, or during the rest position without dentures.