Miracle-dz/UniFAR-FTUs huggingface dataset:
Cerebral Correlates of Automatic Associations Towards Performance Enhancing Substances

The direct assessment of explicit attitudes toward performance enhancing substances, for example Neuroenhancement or doping in sports, can be affected by social desirability biases and cheating attempts. According to Dual Process Theories of cognition, indirect measures like the Implicit Association Test (IAT) measure automatic associations toward a topic (as opposed to explicit attitudes measured by self-report measures). Such automatic associations are thought to occur rapidly and to evade voluntary control. However, whether or not such indirect tests actually reflect automatic associations is difficult to validate. Electroencephalography (EEG) has a superior time resolution which can differentiate between highly automatic compared to more elaborate processing stages. We therefore used EEG to examine on which processing stages cortical differences between negative or positive attitudes to doping occur, and whether or not these differences can be related to BIAT scores. We tested 42 university students (31 females, 24.43 ± 3.17 years old), who were requested to complete a brief doping IAT (BIAT) on attitudes toward doping. Cerebral activity during doping BIAT completion was assessed using high-density EEG. Behaviorally, participants D-scores exhibited negative attitudes toward doping, represented by faster reaction times in the doping + dislike pairing task. Event-related potentials (ERPs) revealed earliest effects between 200 and 300 ms. Here, a relatively larger occipital positivity was found for the doping + dislike pairing task. Further, in the LPP time range between 400 and 600 ms a larger late positive potential was found for the doping + dislike pairing task over central regions. These LPP amplitude differences were successfully predicting participants' BIAT D-scores. Results indicate that event-related potentials differentiate between positive and negative doping attitudes at stages of mid-latency. However, it seems that IAT scores can be predicted only by the later occurring LPP. Our study is the first to investigate the cerebral correlates that contribute to test scores obtained in the indirect testing of automatic associations toward doping. The implications of our results for the broader NE concept are discussed in light of the conceptual similarity of doping and NE.
Morphology and composition of oxidized InAs nanowires studied by combined Raman spectroscopy and transmission electron microscopy

Any device exposed to ambient conditions will be prone to oxidation. This may be of particular importance for semiconductor nanowires because of the high surface-to-volume ratio and only little is known about the consequences of oxidation for these systems. Here, we study the properties of indium arsenide nanowires which were locally oxidized using a focused laser beam. Polarization dependent micro-Raman measurements confirmed the presence of crystalline arsenic, and transmission electron microscopy diffraction showed the presence of indium oxide. The surface dependence of the oxidation was investigated in branched nanowires grown along the [ 0001 ] and [ 01 1 ¯ 0 ] wurtzite crystal directions exhibiting different surface facets. The oxidation did not occur at the [ 01 1 ¯ 0 ] direction. The origin of this selectivity is discussed in terms transition state kinetics of the free surfaces of the different crystal families of the facets and numerical simulations of the laser induced heating.
Tumor necrosis correlates with angiogenesis and is a predictor of poor prognosis in malignant mesothelioma.

OBJECTIVES Malignant mesothelioma (MM) is a fatal tumor of increasing incidence related to asbestos exposure. Microscopic tumor necrosis (TN) is a poor prognostic factor in solid tumors, but it has not been characterized in MM. We wished to evaluate the incidence of TN in MM and its correlations with clinicopathologic factors, angiogenesis, and survival. METHODS TN was graded in 171 routine formalin-fixed, paraffin-embedded hematoxylin-eosin-stained tumor sections by two independent observers. Angiogenesis was assessed by the microvessel count (MVC) of CD34 immunostained sections. TN was correlated with survival by Kaplan-Meier and log-rank analysis, and stepwise, multivariate Cox models were used to compare TN with angiogenesis and established prognostic factors and prognostic scoring systems. RESULTS TN was identified in 39 cases (22.8%) and correlated with low hemoglobin (p = 0.01), thrombocytosis (p = 0.04), and high MVC (p = 0.02). TN was a poor prognostic factor in univariate analysis (p = 0.008). Patients with TN had a median survival of 5.3 months vs 8.3 months in negative cases. Independent indicators of poor prognosis in multivariate analysis were nonepithelioid cell type (p = 0.0001), performance status > 0 (p = 0.007), and increasing MVC (p = 0.004) but not TN. TN contributed independently to the European Organisation for Research and Treatment of Cancer (EORTC) [p = 0.03] and to the Cancer and Leukemia Group B (CALGB) [p = 0.03] prognostic groups in respective multivariate Cox analyses. CONCLUSIONS TN correlates with angiogenesis and is a poor prognostic factor in MM. TN contributes to the EORTC and CALGB prognostic scoring systems.
MRI-based 3 D Finite Element Analysis and Acoustic Tube Modeling of Vocal Tract for / r / Phoneme

The causal relationship between the geometry of the vocal tract and the speech sound produced can be studied using acoustic models of the human vocal tract. This project involves 3D finite element analysis (FEA) and acoustic tube modeling of the human vocal tract phonating the /r/ sound. This requires extraction of 3D tract geometry information from magnetic resonance images (MRI) of the tract using medical image processing techniques. Results obtained from the FEA simulation can identify a more accurate area funciton extraction method and the correct acoustic tube configuration, permitting important improvements to acoustic tube modeling for the liquid sound /r/. A better understanding of the vocal tract articulation for liquid sound /r/ would be beneficial to clinical applications as well as advancement in speech technology such as speech therapy, speech and speaker verification systems, and speech synthesis technology.
Syntactic categories in the speech of young children: the case of the determiner

ABSTRACT There has been a growing trend in recent years towards the attribution of adult-like syntactic categories to young language-learning children. This is based, at least in part, on studies which claim to have found positive evidence for syntactic phrase structure categories in young children's speech. However, these claims contradict the findings of previous research which suggest that the categories underlying children's early multi-word speech are much more limited in scope. The present study represents an attempt to reconcile the findings of these different lines of research by focusing specifically on Valian's (1986) criteria for attributing the syntactic category of determiner to young children. The aim is, firstly, to replicate Valian's results regarding her determiner criteria on a new sample of seven children between the ages of 1;20 and 2;6; secondly, to investigate the extent to which children show overlap in the contexts in which they use different determiner types; and, thirdly, to compare this with a controlled measure of the overlap shown by competent adult speakers. The results suggest that Valian's criteria for attributing a syntactic determiner category are too generous and could be passed by children with a relatively small amount of limited scope knowledge. They also provide at least some evidence that a limited scope formula account of children's early determiner use may fit the data better than an adult-like syntactic account.
Classifying malignant brain tumours from 1H-MRS data using Breadth Ensemble Learning

In neuro oncology, the accurate diagnostic identification and characterization of tumours is paramount for determining their prognosis and the adequate course of treatment. This is usually a difficult problem per se, due to the localization of the tumour in an extremely sensitive and difficult to reach organ such as the brain. The clinical analysis of brain tumours often requires the use of non-invasive measurement methods, the most common of which resort to imaging techniques. The discrimination between high-grade malignant tumours of different origin but similar characteristics, such as glioblastomas and metastases, is a particularly difficult problem in this context. This is because imaging techniques are often not sensitive enough and their spectroscopic signal is overall too similar. In spite of this, machine learning techniques, coupled with robust feature selection procedures, have recently made substantial inroads into the problem. In this study, magnetic resonance spectroscopy data from an international, multi-centre database were used to discriminate between these two types of malignant brain tumours using ensemble learning techniques, with a focus on the definition of a feature selection method specifically designed for ensembles. This method, Breadth Ensemble Learning, takes advantage of the fact that many of the frequencies of the available spectra convey no relevant information for the discrimination of the tumours. The potential of the proposed method is supported by some of the best results reported to date for this problem.
CADM1/TSLC1 inactivation by promoter hypermethylation is a frequent event in colorectal carcinogenesis and correlates with late stages of the disease

Cell adhesion molecule 1 (CADM1/TSLC1), a putative tumor suppressor involving in cell adhesion, proliferation and apoptosis, is frequently inactivated in several carcinomas due to promoter hypermethylation. But alterations of CADM1/TSLC1 in colorectal carcinogenesis and clinical significance have not been elucidated yet. The aim of this study was to determine the role of functional inactivation of CADM1/TSLC1 gene in colorectal tumorigenesis and its potential as a novel epigenetic marker for clinical assessment of patients with colorectal cancer. We measured CADM1/TSLC1 expression levels in 8 colorectal cancer cell lines, 54 primary colorectal carcinomas and their corresponding non‐cancerous tissues by reverse transcription polymerase chain reaction, western blot analysis and immunohistochemistry. We analyzed CADM1/TSLC1 promoter methylation status by bisulfite genomic sequencing and the methylation special polymerase chain reaction, and evaluated its correlation with clinicopathological characteristics. All statistical tests were 2‐sides. Downregulation of CADM1/TSLC1 expression was observed in 7 of 8 (88%) colorectal cancer cell lines and in 39 of 54 (72%) primary colorectal carcinomas. Hypermethylation of CADM1/TSLC1 promoter region occurred in 6 of 8 (75%) colorectal cancer cell lines and 32 of 54 (59%) primary colorectal carcinomas, and was correlated with advanced colorectal carcinoma. Epigenetic inactivation of CADM1/TSLC1 gene is a frequent alteration in development of colorectal cancer and can be a potential biomarker for molecular staging of patients with colorectal cancer.
Effect of Estimated Plasma Volume Reduction on Renal Function for Acute Heart Failure Differs Between Patients With Preserved and Reduced Ejection Fraction

Background—The prognostic relevance of plasma volume reduction (PVR) in acute heart failure patients remains unclear because of the confounding hemodynamic effect of left ventricular ejection fraction impairment on kidney function. Methods and Results—Subjects enrolled in the West Tokyo Heart Failure Registry were examined. The PV at admission and discharge was estimated from the subjects’ body weight and its deviation from the ideal body weight. Patients in the top tertile of estimated PVR were classified as PVR+. Of the 381 patients with acute heart failure, 181 (47.5%) had heart failure with preserved ejection fraction (HFpEF). Estimated PVR was associated with worsening renal function in the HFpEF (odds ratio, 3.28; 95% confidence interval, 1.55–6.96; P=0.002) but not in the heart failure with reduced ejection fraction cohort (odds ratio, 1.22; 95% confidence interval, 0.61–2.42; P=0.57). This association in the HFpEF cohort remained significant after adjusting for a history of hypertension and diabetes mellitus and the estimated glomerular filtration rate (odds ratio, 3.34; 95% confidence interval, 1.52–7.33; P=0.003). The use of intravenous diuretics was a significant predictor of PVR in the HFpEF and heart failure with reduced ejection fraction groups. Conclusions—The effect of estimated PVR differs by HF type, and the estimated PVR during hospitalization is a predictor of worsening renal function in patients with HFpEF but not in heart failure with reduced ejection fraction. Clinical Trial Registration—URL: http://www.umin. ac.jp/ctr/index-j.html. Unique identifier: UMIN000001549.
Linearization of Magnetic Sensors With a Weakly Pinned Free-Layer MTJ Stack Using a Three-Step Annealing Process

In this paper, a three-step magnetic annealing process is used to linearize magnetic tunnel junctions (MTJs) with two exchange pinning layers: one used to strongly pin the reference synthetic antiferromagnet (SAF) and the other one used to weakly pin the magnetic sensing layer. With respect to a more conventional two-step annealing process, the advantage of the three annealing cycle is to provide independent control over the three relevant internal fields, which apart from the demagnetizing field, control the linear response of large area/low aspect ratio MTJs: the sensing layer soft pinning field (SL-Hex), the sensing layer uniaxial anisotropy field (SL-Hk), and the reference layer strong pinning field (RL-Hex). As a result of the three annealing process, a configuration, where SL-Hk and SL-Hex point both in a direction orthogonal to RL-Hex, can be achieved resulting in very good linearity and low coercivity without compromising the sensitivity of the devices, as desired for applications, such as magnetocardiography that targets the detection of magnetic fields in the pT/Hz0.5 range at room temperature and low frequencies within the 1/f noise.
Packets scheduling for optical SDL LIFO buffers

The lack of optical buffer is still one of the main problems that hinder the development of all optical network. The current works on this topic mainly focus on the emulation of optical buffers by using bufferless switch fabric and fiber delay line (SDL). Recent advances have shown the feasibility of emulating many kinds of optical buffers, such as First In First Out (FIFO) buffer, priority buffer etc. The Last In First Out (LIFO) buffer is another important network component that can be used for congestion control and providing quality of service guarantee in the network. In [1] Huang et al. introduced a recursive construction of LIFO buffer with buffer size B by using no less than 9 log B delay lines. In this paper, we explore a more effective construction of optical LIFO buffer from SDL and the feedback switch architecture. Based on such an architecture, a scheduling algorithm is proposed to emulate the LIFO buffer of size B with 2 log B delay lines.
Mechanics of peristaltic locomotion and role of anchoring

Limbless crawling is a fundamental form of biological locomotion adopted by a wide variety of species, including the amoeba, earthworm and snake. An interesting question from a biomechanics perspective is how limbless crawlers control their flexible bodies in order to realize directional migration. In this paper, we discuss the simple but instructive problem of peristalsis-like locomotion driven by elongation–contraction waves that propagate along the body axis, a process frequently observed in slender species such as the earthworm. We show that the basic equation describing this type of locomotion is a linear, one-dimensional diffusion equation with a time–space-dependent diffusion coefficient and a source term, both of which express the biological action that drives the locomotion. A perturbation analysis of the equation reveals that adequate control of friction with the substrate on which locomotion occurs is indispensable in order to translate the internal motion (propagation of the elongation–contraction wave) into directional migration. Both the locomotion speed and its direction (relative to the wave propagation) can be changed by the control of friction. The biological relevance of this mechanism is discussed.
Prediction model for adult height of small for gestational age children at the start of growth hormone treatment.

CONTEXT GH treatment is approved for short children born small for gestational age (SGA). The optimal dose is not yet established. OBJECTIVE Our objective was to develop a model for prediction of height at the onset of puberty and of adult height (AH). DESIGN AND SETTING Two GH studies were performed in short SGA children. PATIENTS/INTERVENTION A total of 150 SGA children with height sd scores (SDS) less than -2, age 3 yr or older, no signs of catch-up growth, available height at the onset of puberty, and at least 1 yr of GH treatment before the onset of puberty were studied. In one study, patients were randomly assigned to either 0.033 or 0.067 mg/kg x d; in the other study all received 0.033 mg/kg x d. In 71 children, AH was reached. MAIN OUTCOME MEASURES Height SDS at the onset of puberty and AH SDS were calculated. RESULTS Determinants positively related to height SDS at the onset of puberty were: height SDS at the start; target height SDS; and GH dose, whereas age at the start and female gender were negatively related. Positively related to AH SDS were: height SDS and chronological age--bone age at the start; target height SDS; and GH dose, whereas serum IGF binding protein (IGFBP)-3 SDS at the start was negatively related. There was a significant interaction between GH dose and IGFBP-3 SDS, indicating a smaller GH dose effect for higher levels of IGFBP-3. The final model explained 57% of the variance in height SDS at the onset of puberty and 41% of AH SDS. CONCLUSIONS The prediction model for height SDS at the onset of puberty and AH SDS of short SGA children treated with GH provides useful information about the expected long-term growth. Because GH dosage is one of the determinants, the model aids in determining the optimal GH dose for each child.
Quality of Life One Year after Coronary Artery Bypass Graft Surgery

Background Coronary artery bypass graft (CABG) is a treatment strategy to relieve the symptoms of coronary artery disease (CAD). Based on determining the long term outcome of CABG using SF-36 Health Related Quality Of Life (HRQOL) questionnaire, the present study was conducted in our center to determine the CABG results one-year after the operation. Methods Between March 2005 and August 2009, 112 patients with coronary heart disease (CHD) who underwent coronary artery bypass graft (CABG) were enrolled. Patients completed SF-36 HRQOL general health status questionnaire. Stepwise multiple linear regression models were used to detect independent variables predicting changes in each eight subscales of SF-36 questionnaire. Results The mean age of patients was 61.4±0.9 years and most of them were male with three vessel diseases that were on pump CABG. The mean physical and mental component summary scores were 59.5±0.9 and 60.2±0.9, respectively. Physical functioning (PF) and role physical (RP) improved in males. Regression models showed that there were some statistical models with low R-square to predict role emotional (RE), general health (GH), PF and RP according to ejection fraction after surgery, diabetes, pump type of CABG and male gender. Conclusion CABG has led to higher and more satisfactory outcomes for PF, RP and RE but lower in other scales comparing with normative data of the society and one-year post-operative scores of other studies. It could mostly be attributed to unmodified risk factors and progression of existing comorbidities.
Influences of valley form and land use on large river and floodplain habitats in Puget Sound

In this paper, we use a system‐wide census of large river and floodplain habitat features to evaluate influences of valley form and land use on salmon habitats along 2,237 km of river in the Puget Sound region of Washington State, USA. We classified the study area by geomorphic process domains to examine differences in natural potential to form floodplain habitats among valley types, and by dominant land cover to examine land use influences on habitat abundance and complexity. We evaluated differences in aquatic habitat among strata in terms of metrics that quantify the length of main channels, side channels, braid channels, and area of wood jams. Among geomorphic process domains, habitat metrics standardized by main channel length were lowest in canyons where there is limited channel migration and less potential to create side channels or braids, and highest in post‐glacial and mountain valleys where island‐braided channels tend to form. Habitat complexity was lower in glacial valleys (generally meandering channels) than in post‐glacial valleys. Habitat abundance and complexity decreased with increasing degree of human influence, with all metrics being highest in areas classified as forested and lowest in areas classified as developed. Using multiple‐year aerial photography, we assessed the ability of our methods to measure habitat changes through time in the Cedar and Elwha Rivers, both of which have recent habitat restoration activity. We were able to parse out sources of habitat improvement or degradation through time, including natural processes, restoration, or development. Our investigation indicates that aerial photography can be an effective and practical method for regional monitoring of status and trends in numerous habitats.
Serum Parathyroid Hormone and 25‐Hydroxyvitamin D Concentrations and Risk of Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis

Background Heart failure (HF) is common and is associated with high mortality. We aimed to determine associations of serum parathyroid hormone (PTH) and 25‐hydroxyvitamin D (25[OH]D) with incident HF and left ventricular mass. Methods and Results Among 6459 participants in the community‐based Multi‐Ethnic Study of Atherosclerosis, all of whom were free of prevalent clinical cardiovascular disease, we measured serum concentrations of PTH and 25(OH)D at the baseline examination. In longitudinal analyses, we tested associations of PTH and 25(OH)D with incident HF events, adjudicated by a panel of physicians. In cross‐sectional analyses of a subset of 4763 participants, we tested associations of PTH and 25(OH)D with left ventricular mass, measured by cardiac magnetic resonance imaging at baseline. Multivariable Cox proportional hazard and linear regression models were adjusted for demographics, physical examination measures, comorbidity, kidney function, and other mineral metabolism markers. Mean age was 62 years and 53% of participants were female. There were 180 incident HF events over a median (interquartile range) follow‐up time of 8.46 (7.67 to 8.63) years. Compared with participants with PTH <65 pg/mL, PTH ≥65 pg/mL was associated with a 50% greater risk of incident HF (95% CI: 3% to 210%) and a 5.3 g higher left ventricular mass (95% CI: 2.6, 7.9 g). In contrast, there was no association of 25(OH)D with risk of incident HF or elevated left ventricular mass. Conclusions In a racially/ethnically diverse population without prevalent cardiovascular disease, higher serum PTH concentration was associated with increased left ventricular mass and increased risk of incident HF. Further studies should be pursued to determine whether PTH excess may be a modifiable risk factor for HF.