Miracle-dz/UniFAR-FTUs huggingface dataset:
Group comparison of subjects' predictions of performance and actual experimental performance: Hypnotic deafness and the hidden observer phenomena

In an effort to delineate the identified behavior of suggested deafness and post-deafness responding in the domain of hypnosis, normative data are presented on 189 undergraduates. A procedure which minimizes artifact effects and also provides information about the expectancies towards the performance of the above mentioned behaviors was presented. One hundred twenty (120) subjects were divided into three (3) groups, balanced for sex, experience with hypnosis, and handedness. Experimenters were blind to experimental hypotheses as assessed on preand post-experiment questionnaires. The control group received a pre-inquiry questionnaire that presented the explicit description of the experimental manipulations and requested that they respond within a simulator rationale --"as they think a highly hypnotizable subject would respond" -according to specific scoring criteria. Following the completion of the pre-inquiry questionnaire the control group was administered the Harvard Group Scale of Hypnotic Susceptibility: Form A (H G S H S :A ) . Both experimental groups were administered the HGSHS:A with the addition of a suggestion of deafness, followed by three loud bangs, screams to wake up, and four post-deafness suggestions. In addition one of the experimental groups was presented with the simulator rationale before the presentation of the deafness suggestion. Experimental subjects reported their behavior in the H G SHS:A response booklets which included the explicit description of the manipulations and scoring criteria noted above. The description of the experimental manipulations and the scoring criteria were identical for both the control group and the experimental groups, thus providing a common scale of measurement from which group percentages and mean differences could be calculated. As had been predicted the mean differences between the prediction of performance and actual experimental performance was highly significant. Furthermore, experimental data on the frequency of hypnotic deafness, and the advisability of using subjective reports as correctives for objective scores is presented. Findings are interpreted in terms of research implications that the procedure provides in delineating a specified behavior in the domain of hypnosis. Director: John G. Watkins
Efficacy and Safety of 3 Different Anesthesia Techniques Used in Total Hip Arthroplasty

Background This study compared the efficacy and safety of 3 different anesthesia techniques used in total hip arthroplasty (THA). Material/Methods We allocated 198 patients preparing to undertake THA into 3 groups: general anesthesia group (GA group, n=66), caudal epidural anesthesia group (CEA group, n=66), and spinal-epidural anesthesia group (SEA group, n=66). We compared postoperative adverse effects occurring in patients of the 3 anesthesia groups. The Visual Analog Scale (VAS) score, Minimum Mental State Examination (MMSE) score, and β-amyloid (Aβ) expression were calculated to determine the effects of different anesthesia on the postoperative pain and cognitive dysfunction of patients. Results The CEA and SEA groups had lower rates of perioperative adverse effects than in the GA group. Patients in the GA group required significantly higher administration of analgesics after the surgery than those in CEA and SEA groups. Higher Aβ expression levels and VAS scores, as well as lower MMSE scores, were also seen in the GA group compared with the other 2 groups. Conclusions CEA and SEA were more effective than GA in THA, and CEA seemed to be a better anesthesia technique than SEA.
Using Pronunciation-Based Morphological Subword Units to Improve OOV Handling in Keyword Search

Out-of-vocabulary (OOV) keywords present a challenge for keyword search (KWS) systems especially in the low-resource setting. Previous research has centered around approaches that use a variety of subword units to recover OOV words. This paper systematically investigates morphology-based subword modeling approaches on seven low-resource languages. We show that using morphological subword units (morphs) in speech recognition decoding is substantially better than expanding word-decoded lattices into subword units including phones, syllables and morphs. As alternatives to grapheme-based morphs, we apply unsupervised morphology learning to sequences of phonemes, graphones, and syllables. Using one of these phone-based morphs is almost always better than using the grapheme-based morphs, but the particular choice varies with the language. By combining the different methods, a substantial gain is obtained over the best single case for all languages, especially for OOV performance.
Internal photon and electron dosimetry of the newborn patient---a hybrid computational phantom study

Estimates of radiation absorbed dose to organs of the nuclear medicine patient are a requirement for administered activity optimization and for stochastic risk assessment. Pediatric patients, and in particular the newborn child, represent that portion of the patient population where such optimization studies are most crucial owing to the enhanced tissue radiosensitivities and longer life expectancies of this patient subpopulation. In cases where whole-body CT imaging is not available, phantom-based calculations of radionuclide S values—absorbed dose to a target tissue per nuclear transformation in a source tissue—are required for dose and risk evaluation. In this study, a comprehensive model of electron and photon dosimetry of the reference newborn child is presented based on a high-resolution hybrid-voxel phantom from the University of Florida (UF) patient model series. Values of photon specific absorbed fraction (SAF) were assembled for both the reference male and female newborn using the radiation transport code MCNPX v2.6. Values of electron SAF were assembled in a unique and time-efficient manner whereby the collisional and radiative components of organ dose-–for both self- and cross-dose terms—were computed separately. Dose to the newborn skeletal tissues were assessed via fluence-to-dose response functions reported for the first time in this study. Values of photon and electron SAFs were used to assemble a complete set of S values for some 16 radionuclides commonly associated with molecular imaging of the newborn. These values were then compared to those available in the OLINDA/EXM software. S value ratios for organ self-dose ranged from 0.46 to 1.42, while similar ratios for organ cross-dose varied from a low of 0.04 to a high of 3.49. These large discrepancies are due in large part to the simplistic organ modeling in the stylized newborn model used in the OLINDA/EXM software. A comprehensive model of internal dosimetry is presented in this study for the newborn nuclear medicine patient based upon the UF hybrid computational phantom. Photon dose response functions, photon and electron SAFs, and tables of radionuclide S values for the newborn child-–both male and female-–are given in a series of four electronic annexes available at stacks.iop. org/pmb/57/1433/mmedia. These values can be applied to optimization studies of image quality and stochastic risk for this most vulnerable class of pediatric patients.
Latent class instrumental variables: a clinical and biostatistical perspective

In some two‐arm randomized trials, some participants receive the treatment assigned to the other arm as a result of technical problems, refusal of a treatment invitation, or a choice of treatment in an encouragement design. In some before‐and‐after studies, the availability of a new treatment changes from one time period to this next. Under assumptions that are often reasonable, the latent class instrumental variable (IV) method estimates the effect of treatment received in the aforementioned scenarios involving all‐or‐none compliance and all‐or‐none availability. Key aspects are four initial latent classes (sometimes called principal strata) based on treatment received if in each randomization group or time period, the exclusion restriction assumption (in which randomization group or time period is an instrumental variable), the monotonicity assumption (which drops an implausible latent class from the analysis), and the estimated effect of receiving treatment in one latent class (sometimes called efficacy, the local average treatment effect, or the complier average causal effect). Since its independent formulations in the biostatistics and econometrics literatures, the latent class IV method (which has no well‐established name) has gained increasing popularity. We review the latent class IV method from a clinical and biostatistical perspective, focusing on underlying assumptions, methodological extensions, and applications in our fields of obstetrics and cancer research. Copyright © 2015 John Wiley & Sons, Ltd.
Contributions of bilingualism and public speaking training to cognitive control differences among young adults

The Flanker and Number Stroop tasks, and the Wisconsin Card Sorting Test (WCST) were adopted to examine how bilingualism and public speaking training would contribute to cognitive control differences among young adults. Four groups of participants (of similar cultural and language backgrounds) were tested: monolinguals, general bilinguals, L1 public speaking bilinguals, and L2 public speaking bilinguals. Both ANOVA and multiple regression analyses showed that public speaking experience (esp. in L2) significantly contributed to conflict monitoring as tested in the global reaction times in the Flanker and Number Stroop tasks, whereas bilingualism (L2 verbal fluency, to be more specific) significantly contributed to mental set shifting as tested in the WCST. These results suggest that specific aspects of language experience, either in L1 or in L2, may incur enhancement in specific aspects of cognitive control, which has implications for bilingual advantage research.
New Evidence on the Association between Prediagnostic Thyroid-Stimulating Hormone Levels and Thyroid Cancer Risk

Thyroid-stimulating hormone (TSH) has long been hypothesized to play a role in thyroid cancer development in humans, including as a mediator of the observed associations for ionizing radiation, obesity, smoking, and iodine intake, among other known and suspected risk (and protective) factors, due to
Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

The reelin signaling pathway regulates nervous system function after birth, in addition to its role in regulating neuronal positioning during embryogenesis. The receptor-dependent, reelin-induced tyrosine phosphorylation of the Dab1 docking protein is an established prerequisite for biological responses to this ligand. Here we show that the inactivation of a conditional Dab1 allele reduces process complexity in correctly positioned neurons in the CA1 region of the mouse hippocampus after birth. Reelin stimulation of cultured hippocampal neurons enhances dendritogenesis by approximately twofold and in a manner dependent on Src family kinases. This enhancement is blocked by reducing expression of Crk family proteins, adaptor molecules that interact with Dab1 in a tyrosine phosphorylation-dependent manner. Retrovirally expressed inhibitory RNAs used to reduce Crk and CrkL expression did not block BDNF-enhanced dendritogenesis or influence axonogenesis. Together, this demonstrates that the Crk family proteins are important downstream components of the reelin signaling pathway in the regulation of postnatal hippocampal dendritogenesis.
Prevalence and factors associated with problematic internet use: an Italian survey among L’Aquila students.

AIM In this study we examined the prevalence of internet addiction (IA) and its associated factors in a sample of Italian students. MATERIALS AND METHODS This is an observational study that involved 1403 students aged 15-24 and conducted in L’Aquila, Italy. 1129 students accepted to participate in our study and completed the Internet Addiction Test: 41% were male and the mean age of total sample was 19±2.8 years. RESULTS The prevalence of “average user” was 51% (95% CI: 48-54). The prevalence of “problematic user” was 23% (95% CI: 21-26). Among the students with a problematic use, 8 were addicted, the 0.7% in the whole sample. There was a significant age difference (p=0.029), but no gender difference (p=0.311) between “average users” and “problematic users”. The association of internet use and educational level (School or University) was not significant (p=0.704). DISCUSSION Our results showed that about one student out of 100 had an IA. Gender and educational level were not significantly associated with IA. Instead, we found a strong association with age: there was not a decrease of internet use during a lifetime, with negative consequences on quality of life. CONCLUSION Our study reported a percentage of 30% of problematic internet use among students. These findings suggest the importance of early detection among youth and of structured interventions that should be carried out to prevent abnormal global life functioning.
CRISPR/Cas9-mediated genome editing in a reef-building coral

Significance Coral reefs are biodiversity hotspots of great ecological, economic, and aesthetic importance. Their global decline due to climate change and other anthropogenic stressors has increased the urgency to understand the molecular bases of various aspects of coral biology, including the interactions with algal symbionts and responses to stress. Recent genomic and transcriptomic studies have yielded many hypotheses about genes that may be important in such processes, but rigorous testing of these hypotheses will require the generation of mutations affecting these genes. Here, we demonstrate the efficient production of mutations in three target genes using the recently developed CRISPR/Cas9 gene-editing technique. By clarifying aspects of basic coral biology, such genetic approaches should also provide a more solid foundation for coral-conservation efforts. Reef-building corals are critically important species that are threatened by anthropogenic stresses including climate change. In attempts to understand corals’ responses to stress and other aspects of their biology, numerous genomic and transcriptomic studies have been performed, generating a variety of hypotheses about the roles of particular genes and molecular pathways. However, it has not generally been possible to test these hypotheses rigorously because of the lack of genetic tools for corals. Here, we demonstrate efficient genome editing using the CRISPR/Cas9 system in the coral Acropora millepora. We targeted the genes encoding fibroblast growth factor 1a (FGF1a), green fluorescent protein (GFP), and red fluorescent protein (RFP). After microinjecting CRISPR/Cas9 ribonucleoprotein complexes into fertilized eggs, we detected induced mutations in the targeted genes using changes in restriction-fragment length, Sanger sequencing, and high-throughput Illumina sequencing. We observed mutations in ∼50% of individuals screened, and the proportions of wild-type and various mutant gene copies in these individuals indicated that mutation induction continued for at least several cell cycles after injection. Although multiple paralogous genes encoding green fluorescent proteins are present in A. millepora, appropriate design of the guide RNA allowed us to induce mutations simultaneously in more than one paralog. Because A. millepora larvae can be induced to settle and begin colony formation in the laboratory, CRISPR/Cas9-based gene editing should allow rigorous tests of gene function in both larval and adult corals.
Learning from Others' HIV Testing: Updating Beliefs and Responding to Risk.

An individual who takes an HIV test can be informed about their own status and risk. Similarly, when friends, family or neighbors learn of a person's HIV status, they may update their beliefs about HIV infection among people they know. Using an experiment conducted in rural Malawi which randomly assigned incentives to learn HIV results, we find that as people in the community learn their HIV results, individuals revise their beliefs downward about deaths attributable to HIV/AIDS. We find corresponding behavioral responses with a significant decrease in condom use and no significant increase in multiple partnerships among those who are HIV-negative.
MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small noncoding RNAs targeting multiple mRNAs, has revealed a new level of gene expression regulation. To determine whether miRNAs play a role in the malignant transformation of plasma cells (PCs), we have used both miRNA microarrays and quantitative real time PCR to profile miRNA expression in MM-derived cell lines (n = 49) and CD138+ bone marrow PCs from subjects with MM (n = 16), monoclonal gammopathy of undetermined significance (MGUS) (n = 6), and normal donors (n = 6). We identified overexpression of miR-21, miR-106b∼25 cluster, miR-181a and b in MM and MGUS samples with respect to healthy PCs. Selective up-regulation of miR-32 and miR-17∼92 cluster was identified in MM subjects and cell lines but not in MGUS subjects or healthy PCs. Furthermore, two miRNAs, miR-19a and 19b, that are part of the miR-17∼92 cluster, were shown to down regulate expression of SOCS-1, a gene frequently silenced in MM that plays a critical role as inhibitor of IL-6 growth signaling. We also identified p300-CBP-associated factor, a gene involved in p53 regulation, as a bona fide target of the miR106b∼25 cluster, miR-181a and b, and miR-32. Xenograft studies using human MM cell lines treated with miR-19a and b, and miR-181a and b antagonists resulted in significant suppression of tumor growth in nude mice. In summary, we have described a MM miRNA signature, which includes miRNAs that modulate the expression of proteins critical to myeloma pathogenesis.
Modelling quality dynamics, business value and firm performance in a big data analytics environment

Big data analytics have become an increasingly important component for firms across advanced economies. This paper examines the quality dynamics in big data environment that are linked with enhancing business value and firm performance (FPER). The study identifies that system quality (i.e. system reliability, accessibility, adaptability, integration, response time and privacy) and information quality (i.e. completeness, accuracy, format and currency) are key to enhance business value and FPER in a big data environment. The study also proposes that the relationship between quality and FPER is mediated by business value of big data. Drawing on the resource-based theory and the information systems success literature, this study extends knowledge in this domain by linking system quality, information quality, business value and FPER.
Joint associations of insomnia and sleep duration with prevalent diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Inadequate sleep quantity and quality are associated with a higher risk of type 2 diabetes. This relationship is not well‐examined in US Hispanics/Latinos, and prior analyses may be confounded by sleep apnea. This cross‐sectional study examined joint associations of sleep duration and insomnia with diabetes among diverse US Hispanic/Latinos.
Adverse effects of trichothiodystrophy DNA repair and transcription gene disorder on human fetal development

Moslehi R, Signore C, Tamura D, Mills JL, DiGiovanna JJ, Tucker MA, Troendle J, Ueda T, Boyle J, Khan SG, Oh K‐S, Goldstein AM, Kraemer KH. Adverse effects of trichothiodystrophy DNA repair and transcription gene disorder on human fetal development.
Older Sibling Support of Younger Siblings’ Socio-Emotional Development

Siblings play a critical role in the socialization experiences of their younger siblings. Societal values, standards, and customs are transmitted and created through the process of modeling and the construction of shared meaning. It follows, therefore, that the process of socialization may be culturally dependent. Using multiple case studies of five sibling dyads, we aim to examine the process of initiation and co-construction of second-generation Spanish-speaking children while engaged in free play activities. Examination of fieldnotes, videotapes, and transcriptions suggests that younger siblings initiated more interactions than their older siblings. However, older sibling initiations were more likely to lead to co-construction. Moreover, when younger sibling initiations were successful, this process of co-construction appears to be contingent on the support provided by their more skilled older siblings. We suggest that by serving as models, older siblings are fulfilling their familial responsibility and preparing their younger siblings for school-based social interactions.
Sequencing of whole plastid genomes and nuclear ribosomal DNA of Diospyros species (Ebenaceae) endemic to New Caledonia: many species, little divergence

Background and Aims Some plant groups, especially on islands, have been shaped by strong ancestral bottlenecks and rapid, recent radiation of phenotypic characters. Single molecular markers are often not informative enough for phylogenetic reconstruction in such plant groups. Whole plastid genomes and nuclear ribosomal DNA (nrDNA) are viewed by many researchers as sources of information for phylogenetic reconstruction of groups in which expected levels of divergence in standard markers are low. Here we evaluate the usefulness of these data types to resolve phylogenetic relationships among closely related Diospyros species. Methods Twenty-two closely related Diospyros species from New Caledonia were investigated using whole plastid genomes and nrDNA data from low-coverage next-generation sequencing (NGS). Phylogenetic trees were inferred using maximum parsimony, maximum likelihood and Bayesian inference on separate plastid and nrDNA and combined matrices. Key Results The plastid and nrDNA sequences were, singly and together, unable to provide well supported phylogenetic relationships among the closely related New Caledonian Diospyros species. In the nrDNA, a 6-fold greater percentage of parsimony-informative characters compared with plastid DNA was found, but the total number of informative sites was greater for the much larger plastid DNA genomes. Combining the plastid and nuclear data improved resolution. Plastid results showed a trend towards geographical clustering of accessions rather than following taxonomic species. Conclusions In plant groups in which multiple plastid markers are not sufficiently informative, an investigation at the level of the entire plastid genome may also not be sufficient for detailed phylogenetic reconstruction. Sequencing of complete plastid genomes and nrDNA repeats seems to clarify some relationships among the New Caledonian Diospyros species, but the higher percentage of parsimony-informative characters in nrDNA compared with plastid DNA did not help to resolve the phylogenetic tree because the total number of variable sites was much lower than in the entire plastid genome. The geographical clustering of the individuals against a background of overall low sequence divergence could indicate transfer of plastid genomes due to hybridization and introgression following secondary contact.