Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences of Behavioral and Psychological Symptoms of Dementia in Disease Severity in Four Major Dementias

Background/Aims Behavioral and psychological symptoms of dementia (BPSDs) negatively impact the prognosis of dementia patients and increase caregiver distress. The aims of this study were to clarify the differences of trajectories of 12 kinds of BPSDs by disease severity in four major dementias and to develop charts showing the frequency, severity, and associated caregiver distress (ACD) of BPSDs using the data of a Japan multicenter study (J-BIRD). Methods We gathered Neuropsychiatric Inventory (NPI) data of patients with Alzheimer’s disease (AD; n = 1091), dementia with Lewy bodies (DLB; n = 249), vascular dementia (VaD; n = 156), and frontotemporal lobar degeneration (FTLD; n = 102) collected during a 5-year period up to July 31, 2013 in seven centers for dementia in Japan. The NPI composite scores (frequency × severity) of 12 kinds of items were analyzed using a principal component analysis (PCA) in each dementia. The factor scores of the PCA were compared in each dementia by disease severity, which was determined with Clinical Dementia Rating (CDR). Results Significant increases with higher CDR scores were observed in 1) two of the three factor scores which were loaded for all items except euphoria in AD, 2) two of the four factor scores for apathy, aberrant motor behavior (AMB), sleep disturbances, agitation, irritability, disinhibition, and euphoria in DLB, and 3) one of the four factor scores for apathy, depression, anxiety, and sleep disturbances in VaD. However, no increases were observed in any of the five factor scores in FTLD. Conclusions As dementia progresses, several BPSDs become more severe, including 1) apathy and sleep disturbances in AD, DLB, and VaD, 2) all of the BPSDs except euphoria in AD, 3) AMB, agitation, irritability, disinhibition, and euphoria in DLB, and 4) depression and anxiety in VaD. Trajectories of BPSDs in FTLD were unclear.
Prevalence and relationship between major depressive disorder and lung cancer: a cross-sectional study

Objective The aims of this study were to estimate the prevalence and examine the factors associated with major depressive disorder (MDD) in lung cancer patients. Materials and methods This cross-sectional study was carried out in the oncology clinic of the University Hospital, Chiang Mai University, Thailand. Patients with all stages of lung cancer were included in this study. Demographic data of eligible patients were gathered. The Mini-International Neuropsychiatric Interview, Thai version 5.0. 0 was used to identify MDD. The Thai version of the Personal Health Questionnaire Depression Scale was used to assess depression severity. Results A total of 146 lung cancer patients from the outpatient clinic from July to December 2012 were approached. The 104 patients were included and analyzed in this study. Based on the Mini-International Neuropsychiatric Interview, 14.4% of them were defined as having MDD. Multiple linear regression analysis revealed that Chalder Fatigue Scale, Functional Assessment of Cancer Therapy – Lung, and Pittsburgh Sleep Quality Index scores were significantly correlated with MDD in lung cancer patients. Conclusion The results suggest that MDD is more prevalent in lung cancer patients. In addition, fatigue, poor quality of life, and sleep disturbance may increase associated MDD. Because of the small sample size, further studies should be conducted to confirm these results.
The ACRONYM Model-Based Vision System

ACRONYM Is a model-based image understanding system. It demonstrates mechanisms for interpretation of images with generic object classes and generic viewing conditions, in a way that is generalizable. It incorporates a powerful geometric modeling capability with a high level modeling language for natural communication with the user In terms of object models. A user gives high level descriptions of both generic and specific instances of objects. A rule-based Inference system produces a viewpoint dependent symbolic summary of the predicted appearance of the objects. This geometric reasoning capability enables the system to incorporate and relate knowledge and information at different levels. This summary drives a powerful syntactic matcher to find instances of the objects in preprocessed images.
Ethnicity, social factors, illness and suicide: a follow‐up study of a random sample of the Swedish population

The aim of this longitudinal study was to determine the influence of ethnicity, social factors and self‐reported long‐term somatic and psychiatric illness on suicide in a random sample of the Swedish population. The study is based on face‐to‐face interviews conducted between 1979 and 1985 with a random sample of the Swedish population consisting of 47 762 Swedish‐born subjects and 4407 individuals born elsewhere. The sample has been followed via register data concerning cases of suicide (suicides and undetermined deaths) until 31 December 1993. In total, 102 males and 46 females committed suicide prior to this date. Living alone and self‐reported somatic illness with impaired health status were very strong risk factors for suicide, with risk ratios of 2.15 (CI, 1.51–3.05) and 1.80 (1.19–2.72), respectively. Ethnicity, defined as being born outside Sweden, had a risk ratio of 1.87 (1.18–2.97) in a model controlled for sex and age. However, this risk decreased with increasing age in the final model. Furthermore, an increased risk of suicide was found among female subjects living in rented flats and among male subjects irrespective of form of tenure, as well as among residents of large urban areas. Respondents with a self‐reported long‐term psychiatric illness with impaired health status also had a high risk of suicide, which decreased with increasing age. The main finding of this study is that somatic diseases and psychiatric disorders, which are known risk factors for suicide, may be revealed in surveys conducted by interviewers without medical training. Thus self‐reported psychiatric and somatic illness appear to have a good potential for predicting suicide, even if the prevalence of psychiatric disorders is to some extent underestimated.
TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

Significance Microglia (brain macrophages) become rapidly activated in most neuropsychiatric disorders. A popular concept is that a single pathogenic stimulus, such as bacterial lipopolysaccharide (LPS) through Toll-like receptor 4 (TLR4), is sufficient to induce a reactive proinflammatory phenotype in microglia that exerts neurotoxicity. This concept is biologically risky, however. Here we provide evidence that chronic activation with either LPS or the leukocyte cytokine IFN-γ induces different reactive phenotypes in microglia of postnatal hippocampal tissue. Notably, these phenotypes only moderately alter diverse neuronal functions. In contrast, coactivation of TLR4 and IFN-γ receptors results in massive neural dysfunction and death. Thus, activation of TLR4 in microglia in situ requires concomitant IFN-γ signaling from other host immune cells to induce neurodegeneration. Microglia (tissue-resident macrophages) represent the main cell type of the innate immune system in the CNS; however, the mechanisms that control the activation of microglia are widely unknown. We systematically explored microglial activation and functional microglia–neuron interactions in organotypic hippocampal slice cultures, i.e., postnatal cortical tissue that lacks adaptive immunity. We applied electrophysiological recordings of local field potential and extracellular K+ concentration, immunohistochemistry, design-based stereology, morphometry, Sholl analysis, and biochemical analyses. We show that chronic activation with either bacterial lipopolysaccharide through Toll-like receptor 4 (TLR4) or leukocyte cytokine IFN-γ induces reactive phenotypes in microglia associated with morphological changes, population expansion, CD11b and CD68 up-regulation, and proinflammatory cytokine (IL-1β, TNF-α, IL-6) and nitric oxide (NO) release. Notably, these reactive phenotypes only moderately alter intrinsic neuronal excitability and gamma oscillations (30–100 Hz), which emerge from precise synaptic communication of glutamatergic pyramidal cells and fast-spiking, parvalbumin-positive GABAergic interneurons, in local hippocampal networks. Short-term synaptic plasticity and extracellular potassium homeostasis during neural excitation, also reflecting astrocyte function, are unaffected. In contrast, the coactivation of TLR4 and IFN-γ receptors results in neuronal dysfunction and death, caused mainly by enhanced microglial inducible nitric oxide synthase (iNOS) expression and NO release, because iNOS inhibition is neuroprotective. Thus, activation of TLR4 in microglia in situ requires concomitant IFN-γ receptor signaling from peripheral immune cells, such as T helper type 1 and natural killer cells, to unleash neurotoxicity and inflammation-induced neurodegeneration. Our findings provide crucial mechanistic insight into the complex process of microglia activation, with relevance to several neurologic and psychiatric disorders.
Selective and irreversible cell cycle inhibition by diphenyleneiodonium

Because cell proliferation is subject to checkpoint-mediated regulation of the cell cycle, pharmacophores that target cell cycle checkpoints have been used clinically to treat human hyperproliferative disorders. It is shown here that the flavoprotein inhibitor diphenyleneiodionium can block cell proliferation by targeting of cell cycle checkpoints. Brief exposure of mitotically arrested cells to diphenyleneiodonium induces a loss of the mitotic cell morphology, and this corresponds with a decrease in the levels of the mitotic markers MPM2 and phospho-histone H3, as well as a loss of centrosome maturation, spindle disassembly, and redistribution of the chromatin remodeling helicase ATRX. Surprisingly, this mitotic exit resulted in a tetraploidization that persisted long after drug release. Analogously, brief exposure to diphenyleneiodonium also caused prolonged arrest in G1 phase. By contrast, diphenyleneiodonium exposure did not abrogate S phase, although it did result in a subsequent block of G2 cell cycle progression. This indicates that diphenyleneiodonium selectively targets components of the cell cycle, thereby either causing cell cycle arrest, or checkpoint override followed by cell cycle arrest. These irreversible effects of diphenyleneiodonium on the cell cycle may underlie its potent antiproliferative activity.
Duplication of the IGFBP-2 Gene in Teleost Fish: Protein Structure and Functionality Conservation and Gene Expression Divergence

Background Insulin-like growth factor binding protein-2 (IGFBP-2) is a secreted protein that binds and regulates IGF actions in controlling growth, development, reproduction, and aging. Elevated expression of IGFBP-2 is often associated with progression of many types of cancers. Methodology/Principal Findings We report the identification and characterization of two IGFBP-2 genes in zebrafish and four other teleost fish. Comparative genomics and structural analyses suggest that they are co-orthologs of the human IGFBP-2 gene. Biochemical assays show that both zebrafish igfbp-2a and -2b encode secreted proteins that bind IGFs. These two genes exhibit distinct spatiotemporal expression patterns. During embryogenesis, IGFBP-2a mRNA is initially detected in the lens, then in the brain boundary vasculature, and subsequently becomes highly expressed in the liver. In the adult stage, liver has the highest levels of IGFBP-2a mRNA, followed by the brain. Low levels of IGFBP-2a mRNA were detected in muscle and in the gonad in male adults only. IGFBP-2b mRNA is detected initially in all tissues at low levels, but later becomes abundant in the liver. In adult males, IGFBP-2b mRNA is only detected in the liver. In adult females, it is also found in the gut, kidney, ovary, and muscle. To gain insights into how the IGFBP-2 genes may have evolved through partitioning of ancestral functions, functional and mechanistic studies were carried out. Expression of zebrafish IGFBP-2a and -2b caused significant decreases in the growth and developmental rates and their effects are comparable to that of human IGFBP-2. IGFBP-2 mutants with altered IGF binding-, RGD-, and heparin-binding sites were generated and their actions examined. While mutating the RGD and heparin binding sites had little effect, altering the IGF binding site abolished its biological activity. Conclusions/Significance These results suggest that IGFBP-2 is a conserved regulatory protein and it inhibits growth and development primarily by binding to and inhibiting IGF actions in vivo. The duplicated IGFBP-2 genes may provide additional flexibility in the regulation of IGF activities.
Seizures Triggered by July 4th Fireworks in an 8-Year-Old Girl With Perinatal Stroke

Warnings regarding fireworks displays as a possible seizure-producing stimulus have been around for several years, but there is a lack of well-documented cases. This case describes photic- and/or pattern-induced seizures that appeared to be triggered by July 4 fireworks. This 8-year-old girl with hemiplegic cerebral palsy and known seizure disorder because of perinatal right middle cerebral artery stroke had a cluster of seizures within minutes of the onset of a professional fireworks display. The seizures stopped when the child’s eyes were covered and she was taken away from the scene. The importance of photic- and pattern-induced seizures in children is discussed.
Mermin Non-Locality in Abstract Process Theories

The study of non-locality is fundamental to the understanding of quantum mechanics. The past 50 years have seen a number of non-locality proofs, but its fundamental building blocks, and the exact role it plays in quantum protocols, has remained elusive. In this paper, we focus on a particular flavour of non-locality, generalising Mermin's argument on the GHZ state. Using strongly complementary observables, we provide necessary and sufficient conditions for Mermin non-locality in abstract process theories. We show that the existence of more phases than classical points (aka eigenstates) is not sufficient, and that the key to Mermin non-locality lies in the presence of certain algebraically non-trivial phases. This allows us to show that fRel, a favourite toy model for categorical quantum mechanics, is Mermin local. We show Mermin non-locality to be the key resource ensuring the device-independent security of the HBB CQ (N,N) family of Quantum Secret Sharing protocols. Finally, we challenge the unspoken assumption that the measurements involved in Mermin-type scenarios should be complementary (like the pair X,Y), opening the doors to a much wider class of potential experimental setups than currently employed. In short, we give conditions for Mermin non-locality tests on any number of systems, where each party has an arbitrary number of measurement choices, where each measurement has an arbitrary number of outcomes and further, that works in any abstract process theory.
Generalization of the Unified Analytic Melt-Shear Model to Multi-Phase Materials: Molybdenum as an Example

The unified analytic melt-shear model that we introduced a decade ago is generalized to multi-phase materials. A new scheme for calculating the values of the model parameters for both the cold ( T = 0 ) shear modulus ( G ) and the melting temperature at all densities ( ρ ) is developed. The generalized melt-shear model is applied to molybdenum, a multi-phase material with a body-centered cubic (bcc) structure at low ρ which loses its dynamical stability with increasing pressure (P) and is therefore replaced by another (dynamically stable) solid structure at high ρ . One of the candidates for the high- ρ structure of Mo is face-centered cubic (fcc). The model is compared to (i) our ab initio results on the cold shear modulus of both bcc-Mo and fcc-Mo as a function of ρ , and (ii) the available theoretical results on the melting of bcc-Mo and our own quantum molecular dynamics (QMD) simulations of one melting point of fcc-Mo. Our generalized model of G ( ρ , T ) is used to calculate the shear modulus of bcc-Mo along its principal Hugoniot. It predicts that G of bcc-Mo increases with P up to ∼240 GPa and then decreases at higher P. This behavior is intrinsic to bcc-Mo and does not require the introduction of another solid phase such as Phase II suggested by Errandonea et al. Generalized melt-shear models for Ta and W also predict an increase in G followed by a decrease along the principal Hugoniot, hence this behavior may be typical for transition metals with ambient bcc structure that dynamically destabilize at high P. Thus, we concur with the conclusion reached in several recent papers (Nguyen et al., Zhang et al., Wang et al.) that no solid-solid phase transition can be definitively inferred on the basis of sound velocity data from shock experiments on Mo. Finally, our QMD simulations support the validity of the phase diagram of Mo suggested by Zeng et al.
Search behavior of media professionals at an audiovisual archive: A transaction log analysis

Finding audiovisual material for reuse in new programs is an important activity for news producers, documentary makers, and other media professionals. Such professionals are typically served by an audiovisual broadcast archive. We report on a study of the transaction logs of one such archive. The analysis includes an investigation of commercial orders made by the media professionals and a characterization of sessions, queries, and the content of terms recorded in the logs. One of our key findings is that there is a strong demand for short pieces of audiovisual material in the archive. In addition, while searchers are generally able to quickly navigate to a usable audiovisual broadcast, it takes them longer to place an order when purchasing a subsection of a broadcast than when purchasing an entire broadcast. Another key finding is that queries predominantly consist of (parts of) broadcast titles and of proper names. Our observations imply that it may be beneficial to increase support for finegrained access to audiovisual material, for example, through manual segmentation or content-based analysis.
Discovery of a red supergiant counterpart to RX J004722.4–252051, a ULX in NGC 253.

We present two epochs of near-infrared spectroscopy of the candidate red supergiant counterpart to RX J004722.4–252051, a ULX in NGC 253. We measure radial velocities of the object and its approximate spectral type by cross-correlating our spectra with those of known red supergiants. Our VLT/X-shooter spectrum is best matched by that of early M-type supergiants, confirming the red supergiant nature of the candidate counterpart. The radial velocity of the spectrum, taken on 2014 August 23, is 417 ± 4 km s^(−1). This is consistent with the radial velocity measured in our spectrum taken with Magellan/MMIRS on 2013 June 28, of 410 ± 70 km s^(−1), although the large error on the latter implies that a radial velocity shift expected for a black hole of tens of M⊙ can easily be hidden. Using nebular emission lines we find that the radial velocity due to the rotation of NGC 253 is 351 ± 4 km s^(−1) at the position of the ULX. Thus the radial velocity of the counterpart confirms that the source is located in NGC 253, but also shows an offset with respect to the local bulk motion of the galaxy of 66 ± 6 km s^(−1). We argue that the most likely origin for this displacement lies either in a SN kick, requiring a system containing a ≳ 50 M_⊙ black hole, and/or in orbital radial velocity variations in the ULX binary system, requiring a ≳ 100 M_⊙ black hole. We therefore conclude that RX J004722.4–252051 is a strong candidate for a ULX containing a massive stellar black hole.
Antipsychotic-induced metabolic effects in the female rat: Direct comparison between long-acting injections of risperidone and olanzapine

Several antipsychotics have well-known adverse metabolic effects. Studies uncovering molecular mechanisms of such drugs in patients are challenging due to high dropout rates, previous use of antipsychotics and restricted availability of biological samples. Rat experiments, where previously unexposed animals are treated with antipsychotics, allow for direct comparison of different drugs, but have been hampered by the short half-life of antipsychotics in rodents. The use of long-acting formulations of antipsychotics could significantly increase the value of rodent models in the molecular characterization of therapeutic and adverse effects of these agents. However, as long-acting formulations have rarely been used in rodents, there is a need to characterize the basic metabolic phenotype of different antipsychotics. Using long-acting olanzapine injections as a positive control, the metabolic effects of intramuscular long-acting risperidone in female rats were investigated for the first time. Like olanzapine, risperidone induced rapid, significant hyperphagia and weight gain, with concomitant increase in several plasma lipid species. Both drugs also induced weight-independent upregulation of several genes encoding enzymes involved in lipogenesis, but this activation was not confirmed at the protein level. Our findings shed light on the role of drug administration, drug dose and nutritional status in the development of rodent models for adverse metabolic effects of antipsychotic agents.
Algebra of Logic Programming

A declarative programming language has two kinds of semantics The more abstract helps in reasoning about speci cations and correctness while an operational semantics determines the manner of program exe cution A correct program should reconcile its abstract meaning with its concrete interpretation To help in this we present a kind of algebraic semantics for logic pro gramming It lists only those laws that are equally valid for predicate calculus and for the standard depth rst strategy of Prolog An alterna tive strategy is breadth rst search which shares many of the same laws Both strategies are shown to be special cases of the most general strat egy that for tree searching The three strategies are de ned in the lazy functional language Haskell so that each law can be proved by standard algebraic reasoning The laws are an enrichment of the familiar categorical concept of a monad and the links between such monads are explored
Alu elements as regulators of gene expression

Alu elements are the most abundant repetitive elements in the human genome; they emerged 65 million years ago from a 5′ to 3′ fusion of the 7SL RNA gene and amplified throughout the human genome by retrotransposition to reach the present number of more than one million copies. Over the last years, several lines of evidence demonstrated that these elements modulate gene expression at the post-transcriptional level in at least three independent manners. They have been shown to be involved in alternative splicing, RNA editing and translation regulation. These findings highlight how the genome adapted to these repetitive elements by assigning them important functions in regulation of gene expression. Alu elements should therefore be considered as a large reservoir of potential regulatory functions that have been actively participating in primate evolution.