Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural Architecture for Persian Named Entity Recognition

Named entity recognition task is a challenging problem specially for languages with low resources of annotated corpora such as Persian. In this paper, we use deep learning approaches to obtain high performance results without using any specific hand-made features and gazetteers. In the recent years, LSTMs have been observed as the most effective solution for sequence prediction problems like NER. For this purpose, we use a LSTM-CRF approach for Persian NER and combine with the pre-trained word embedding. For achieving language independent vector representation, we use character-based representation. By using a bidirectional LSTM, word and character level features automatically detect and the need for most of hand-engineered features eliminates. This model obtains 86.55% F1 score that is the highest score in compare to previous results in Persian language. We also apply this architecture for dataset in [2] and achieve 84.23% F1 score, published result for this dataset is showed 77.45% F1 score.
Skeletal response to treatment with teriparatide (TPD) after bisphosphonate in post-menopausal women with osteoporosis and a high prevalence of secondary risk factors in real-life setting of a metabolic bone clinic; effect of age and vitamin D status

ABSTRACT Purpose: Teriparatide (TPD) is a skeletal anabolic agent used in patients with severe post-menopausal osteoporosis (PMO) and steroid-induced osteoporosis who are at hish risk of fracture. Predictors of therapeutic response to teriparatide in real-life setting are not well characterised. We investigated potential factors associated with teriparatide response in post-menopausal women with established osteoporosis. Methods: We carried out a retrospective survey of 48 women, aged 73.2 [7.5] years with severe osteoporosis and prevalent fractures treated with TPD according to the NICE criteria. BMD was measured at baseline, 6-12 and 18-24 months at the lumbar spine (LS), total hip (TH) and femoral neck (FN). Bone turnover markers, serum 25 (OH)vitamin D were determined at 3-12 and 12-24 months. Results: BMD increased at 6-12 months (% change mean [SEM] 6.5 [1.1] p = 0.004) and 18-24 months (8.45 % [1.2] p<0.001) at the LS. A significant increase in BMD was observed at FN (3.1 [1.3] % p = 0.02). Changes in BMD at the TH was higher in patients younger than 73 years compared to older women (% change in BMD 4.13 [1.64] % v/s -1.7 [1.1] p = 0.007). Baseline 25 (OH) vitamin D correlated with change in P1NP at 3-12 months (r = 0.45 p = 0.049). Conclusions: TPD-induced changes in BMD at the TH appears may be dependent on age. Vitamin D status may influence the early anabolic effect to TPD. Our data suggest that these factors may be important considerations when initiating and optimising treatment with TPD, although further larger studies are needed to confirm these findings.
Estimating the impact of showroom entertainment on the hourly gaming volume of a Las Vegas hotel

Along with the emergence of mega casino-resorts in the gaming industry, researchers have attempted to estimate the indirect gaming contributions of non-gaming casino amenities such as showroom entertainment and restaurants. However, the daily data of aggregate gaming volumes analyzed in previous gaming research did not allow exploring transient gaming volumes associated with casino amenities during a much narrower range of time periods (i.e., hourly). The current investigation addresses this limitation by proposing a model to examine the relationship between showroom headcounts and hourly slot gaming volumes for the hours falling adjacent to the show’s performance time. Considering a major investment in showroom entertainment at many casinos, the current study will help casino operators evaluate the showroom’s slot gaming contribution.
Phenotypic Trait Identification Using a Multimodel Bayesian Method: A Case Study Using Photosynthesis in Brassica rapa Genotypes

Agronomists have used statistical crop models to predict yield on a genotype-by-genotype basis. Mechanistic models, based on fundamental physiological processes common across plant taxa, will ultimately enable yield prediction applicable to diverse genotypes and crops. Here, genotypic information is combined with multiple mechanistically based models to characterize photosynthetic trait differentiation among genotypes of Brassica rapa. Infrared leaf gas exchange and chlorophyll fluorescence observations are analyzed using Bayesian methods. Three advantages of Bayesian approaches are employed: a hierarchical model structure, the testing of parameter estimates with posterior predictive checks and a multimodel complexity analysis. In all, eight models of photosynthesis are compared for fit to data and penalized for complexity using deviance information criteria (DIC) at the genotype scale. The multimodel evaluation improves the credibility of trait estimates using posterior distributions. Traits with important implications for yield in crops, including maximum rate of carboxylation (Vcmax) and maximum rate of electron transport (Jmax) show genotypic differentiation. B. rapa shows phenotypic diversity in causal traits with the potential for genetic enhancement of photosynthesis. This multimodel screening represents a statistically rigorous method for characterizing genotypic differences in traits with clear biophysical consequences to growth and productivity within large crop breeding populations with application across plant processes.
Infliximab maintains a high degree of clinical response in patients with active psoriatic arthritis through 1 year of treatment: results from the IMPACT 2 trial

Objective: To evaluate the efficacy and safety of infliximab through 1 year in patients with psoriatic arthritis (PsA) enrolled in the IMPACT 2 trial. Methods: In this double blind, placebo controlled, phase III study, 200 patients with active PsA were randomised to receive infusions of infliximab 5 mg/kg or placebo at weeks 0, 2, 6, and every 8 weeks thereafter through 1 year. Patients with persistent disease activity could enter early escape at week 16, and all remaining placebo patients crossed over to infliximab at week 24. Patients randomised to infliximab who had no response or who lost response could escalate their dose to 10 mg/kg starting at week 38. Clinical efficacy was assessed based on the proportion of patients achieving ACR 20 and PASI 75 responses. Major clinical response (that is, maintenance of ACR 70 response for 24 continuous weeks) was assessed for the first time in PsA. Results: Through 1 year of treatment, 58.9% and 61.4% of patients in the randomised infliximab and placebo/infliximab groups, respectively, achieved ACR 20; corresponding figures for PASI 75 were 50.0% and 60.3%. At week 54, major clinical response was achieved by 12.1% of patients in the infliximab group. The safety profile of infliximab through week 54 was consistent with that seen through week 24. Two malignancies occurred: basal cell skin cancer (placebo) and stage I Hodgkin’s lymphoma (infliximab). Conclusion: Infliximab maintains a high degree of clinical efficacy and continues to be well tolerated in patients with PsA through 1 year of treatment.
Effect of object substitution, spontaneous compensation and repetitive training on reaching movements in a patient with optic ataxia

ABSTRACT We report the case of M.B. who demonstrated severe optic ataxia with the right hand following stroke in the left hemisphere. The clinical picture may shed light on both the pathological characteristics of reaching and grasping actions, and potential rehabilitation strategies for optic ataxia. First, M.B. demonstrated a dissociation between severely impaired reaching and relatively spared grasping and tool use skills and knowledge, which confirms that grasping may be more intermingled with non-motoric cognitive mechanisms than reaching. Besides, M.B. ’s reaching performance was sensitive to movement repetition. We observed a substitution effect: Reaching time decreased if M.B. repeatedly reached toward the same object but increased when object identity changed. This may imply that not only object localization but also object identity, is integrated into movement programming in reach-to-grasp tasks. Second, studying M.B. ’s spontaneous compensation strategies ascertained that the mere repetition of reaching movements had a positive effect, to the point M.B. almost recovered to normal level after an intensive one-day repetitive training session. This case study seems to provide one of the first examples of optic ataxia rehabilitation. Reaching skills can be trained by repetitive training even two years post-stroke and despite the presence of visuo-imitative apraxia.
Peer Review in Agricultural Education: Interrater Reliability of Manuscript Reviews for the 2014 National Agricultural Education Research Conference.

This study analyzed 336 peer reviews of 112 manuscripts submitted for possible presentation at the 2014 National Agricultural Education Research Conference (NAERC). There were scoring errors on 6.8% of the reviews; the most frequent errors were failure to record a score or assigning a score above the range of points possible for one or more of the review criteria. The coefficient of variation (CV) for same-paper ratings of manuscript quality ranged from 3.94% to 96.43% with a mean of 19.65% (SD = 15.22%). The interrater reliability for same-paper evaluations of manuscript quality was . 15. The CVs for reviewer same-paper reject-accept recommendations ranged from 0.00% to 98.97% with a mean of 38.80% (SD = 22.72%). The interrater reliability for same-paper reject-accept recommendations was . 09. On 82 (73.21%) manuscripts all three reviewers agreed on the manuscript’s relevance to agricultural education. Mean manuscript quality scores explained 68.3% of the variance in mean reject-accept recommendations leaving 31.7% of the variance unexplained. There were no significant (p > .05) differences by academic rank in ratings of manuscript quality, reject-accept recommendations, or assessments of relevance to agricultural education. The authors offered recommendations for improvement of the NAERC manuscript review process.
Pattern of Antibiotic Prescription for Oral Implant Treatment Among Dentists in Saudi Arabia

Objective: To investigate antibiotic prophylaxis prescription behavior among dentists practicing dental implant surgery in Saudi Arabia. Materials and Methods: An observational questionnaire study was conducted in the period between October 2016 and December 2016. A link to an online previously validated questionnaire was sent to a convenience sample of dentists practicing dental implant placement in the different areas of Saudi Arabia. Absolute frequencies were used to describe the data. Results: One hundred nine completed questionnaires were received. A total of 59.63% (n = 65) of the respondents routinely prescribed prophylactic antibiotics when performing implant surgery. There was a wide variation in the preoperative and postoperative prescription regimens with the majority (67%) starting the antibiotic immediately postoperatively for 3 to 5 days, with no preoperative antibiotic use. Amoxicillin and clavulanic acid combination was the drug of choice for 50.3% of the respondents, whereas 26.6% prescribed amoxicillin as the drug of choice. Conclusion: Although a small study with a low response rate, a wide variation in antibiotic prescribing patterns with respect to the drugs chosen, timing, and duration was found in implant surgery in Saudi Arabia. Dentists should be aware of the risk of antibiotic overuse and start to share in the efforts that aim to reserve the antibiotics to combat life-threatening infections and to reduce development of bacterial resistance to the available antibiotics.
Sound Source Separation Using Spatio-temporal Sound Pressure Distribution Images and Machine Learning

Sound source separation (SSS) using a microphone array is effective in various situations, such as in the recording of target speech in noisy environments. We previously proposed an SSS system using a differential-type array and time-delay neural network (NN). An advantage of the differential-type array was that distortion of the target speech due to the nonlinear property of the NN was prevented. However, the system was only effective for a narrowband signal. For broadband signals (such as speech), a new SSS system is proposed, which extends the previous one in the following two areas. First, the input to the NN is extended to sound pressure distribution images, which are formed based on the microphone outputs. Second, the number of layers in the NN is increased. Computer simulations revealed that the proposed system exhibited higher SSS performance than conventional arrays, including our previous one.
“You Can See How Things Will End by the Way They Begin”: The Contribution of Early Mutual Obligations for the Development of the Psychological Contract

This study explores dynamic processes in the development of the psychological contract, focusing on the interaction of obligations related to the two parties (i.e., employees’ perceptions of both their own and the organization’s obligations fulfillment) on attitudinal outcomes (organizational commitment and turnover intention) during the initial stage of the employment relationship. In a twofold cross-sectional and two-wave study on newly hired correctional police officers, we examined: (a) whether perception of organizational obligations fulfillment moderates the relationship between employee obligations and their attitudes (Study 1, n.500); (b) the direct and moderated influence of perceived obligations at the entrance stage on those in the following months (Study 2, n.223). Results confirmed that, in the eyes of the newcomer, the obligations fulfillment of each of the two parties interact, having an additional effect beyond the main direct effects, in influencing both subsequent obligations perceptions and, through this, the outcome variables. Theoretical and practical implications of the findings are discussed.
Microbial ubiquinones: multiple roles in respiration, gene regulation and oxidative stress management.

Spectacular advances have been made in recent years in our understanding of the structure and function of the membrane-bound protein complexes in respiratory and photosynthetic electron-transport chains. Perhaps as a result of this focus of attention, there is a temptation to regard quinones as a passive pool of redox carriers whose only function is to shuttle reducing equivalents between more ' interesting' protein complexes. However, it is now clear that quinones play additional vital roles in management of oxidative stress and, apparently, gene regulation. The purpose of this review is to give an overview of the different roles quinones fulfil in the prokaryotic cell with emphasis on Escherichia coli, although recent advances in yeast are also covered. The ubiquinone biosynthetic pathway has now been elucidated in both prokaryotes and lower eukaryotes, and a comparison of the numerous enzymes involved in these pathways is included. The literature cited is necessarily selective, with an emphasis on recent work; reviews have been used to cover early work.
Impact of Coexisting Uterine Adenomyosis on the Survival Outcome of Patients with Endometrial Cancer: A Retrospective Cohort Study

Objective: To determine the effects of uterine adenomyosis on endometrial cancerrecurrence rates. Methods: This retrospective cohort study reviewed all consecutive patients diagnosed with endometrial cancerwho underwent total hysterectomy-based surgical staging at Srinagarind Hospital between January, 2010 and January, 2016. The patientswere divided into two groups:a uterine adenomyosisgroup and a non-adenomyosis group. Patient demographics, type of surgery, histopathology, stage of endometrial cancer, adjuvant treatment, and survival outcomes were compared. Results: A total 350 patients were enrolled, with 132 (37.71%) in the adenomyosis group and 218 (62.29%) in the non-adenomyosis group. Deep myometrial invasion and lymphovascular space invasion (LVSI) were more commonly found among patients who had no adenomyosis compared to those with adenomyosis(52.8% vs 39.4%, P=0.02 and 53.2% vs. 38.6%, P=0.01). There were no significant differences in terms of five-year recurrence-free survival (HR=1.47; 95%CI 0.88-2.44) and five-year overall survival (HR=0.81; 95%CI 0.43-1.53) between the two comparison groups. Conclusion: Coexisting uterine adenomyosis in endometrial cancer wasassociated withdeep myometrial invasion and LVSI but did not have significant impact on survival.
Upregulation of Circulating MiR-21 Expression as a Potential Biomarker for Therapeutic Monitoring and Clinical Outcome in Breast Cancer

Background: Aberrant patterns of microRNA expression have been highlighted as a potential clinical biomarker in breast cancer as the most frequent cancer among women that contributes nearly a quarter of total cancer incidence in 2018. Upregulation of microRNA-21 (miR-21) is associated with adverse clinical outcomes in breast cancer. However, the use of circulating free miR-21 as a non-invasive biomarker for diagnosis and therapeutic monitoring in breast cancer is not well established. We quantified the levels of circulating miR-21 expression and analyzed their correlation with clinicopathological variables and progression-free survival. Materials and Methods: This initial study included a cohort of 102 breast cancer patients of different subtypes and clinicat stages. We also included 15 unrelated healthy women. Venous blood from patients was collected at diagnosis and after treatment of surgery and chemotherapy. MiR-21 expression was quantified from total RNA fraction isolated from patient’s plasma. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to analyzed miR-21 expression. Results: Expression of circulating miR-21 was significantly elevated in breast cancer patients compared to healthy women (median miR-21 expression levels were 7.67±2.2 and 1.28±0.16, respectively; p<0.0001). Significant reduction of miR-21 expression was observed in breast cancer patients after completion of surgery and chemotherapy (median miR-21 expression levels were 7.67±2.2 at diagnosis and 2.16±1.28 after treatment, respectively; p<0.0001). MiR-21 expression was higher in breast cancer patients younger than 40-year-old but was not significantly different according to different histopathological grades and clinical stages at diagnosis. Patients with upregulation of circulating miR-21 were associated with poor progression-free survival (median survival 72 vs 86 weeks, respectively; log-rank (Mantel-Cox) test, p=0.049). Conclusion: MiR-21 expression was upregulated in breast cancer patients and might serve as a therapeutic monitoring marker.
Study on Drilling Resistance Reduction of a Seafloor Robotic Explorer Based on the Drilling Properties of Underwater Ground

To utilize seabed mineral resources, which can be found at the bottom of the ocean, it is necessary to collect and analyze samples. Therefore, we intend to develop a seafloor robotic explorer that can excavate and sample the seafloor soil. In a previous study, we developed an underwater drilling robot. This robot could excavate into the ground while underwater. However, this robot had a problem. The actual time taken to complete the excavation was longer than the expected time to complete the excavation. Therefore, the goal of our current study is to reduce the drilling resistance and therefore shorten the completion time. We adjusted the penetration speed and the rotational speed of the drilling robot. As a result, we succeeded in reducing the drilling resistance, which both lowered the excavation energy by 28% and significantly reduced the completion time.
Multidimensional Constellations for Uplink SCMA Systems—A Comparative Study

Sparse code multiple access (SCMA) is a class of non-orthogonal multiple access (NOMA) that is proposed to support uplink machine-type communication services. In an SCMA system, designing multidimensional constellation plays an important role in the performance of the system. Since the behavior of multidimensional constellations highly depends on the type of the channel, it is crucial to employ a constellation that is suitable for a certain application. In this paper, we first highlight and review the key performance indicators (KPIs) of multidimensional constellations that should be considered in their design process for various channel scenarios. We then provide a survey on the known multidimensional constellations in the context of SCMA systems with their design criteria. The performance of some of those constellations are evaluated for uncoded, high-rate, and low-rate LTE turbo-coded SCMA systems under different channel conditions through extensive simulations. All turbo-coded comparisons are performed for bit-interleaved coded modulation, with a concatenated detection and decoding scheme. Simulation results confirm that multidimensional constellations that satisfy KPIs of a certain channel scenario outperform others. Moreover, the bit error rate performance of uncoded systems, and the performance of the coded systems are coupled to their bit-labeling. The performance of the systems also remarkably depends on the behavior of the multiuser detector at different signal-to-noise ratio regions.
Ultrastructural study of wall ontogeny during zygosporogenesis in Rhizopus stolonifer (Mucoraceae), an amended model

The ultrastructural changes of the zygospore and zygosporangial walls of Rhizopus stolonifer during zygosporogenesis were studied by both scanning and transmission electron microscopy. The mature zygosporangial wall is composed of a primary, secondary, and tertiary layers. The mature zygospore wall is also multilayered. It was observed, in contrast to earlier reports, that the inner surface of the tertiary zygosporangial wall and zygospore wall are originally smooth and become warty at maturity. We suggest that this feature of wall development be added to the conventional model of zygosporogenesis in Rhizopus.
Molecular Mechanisms of Acclimatization to Phosphorus Starvation and Recovery Underlying Full-Length Transcriptome Profiling in Barley (Hordeum vulgare L.)

A lack of phosphorus (P) in plants can severely constrain growth and development. Barley, one of the earliest domesticated crops, is extensively planted in poor soil around the world. To date, the molecular mechanisms of enduring low phosphorus, at the transcriptional level, in barley are still unclear. In the present study, two different barley genotypes (GN121 and GN42)—with contrasting phosphorus efficiency—were used to reveal adaptations to low phosphorus stress, at three time points, at the morphological, physiological, biochemical, and transcriptome level. GN121 growth was less affected by phosphorus starvation and recovery than that of GN42. The biomass and inorganic phosphorus concentration of GN121 and GN42 declined under the low phosphorus-induced stress and increased after recovery with normal phosphorus. However, the range of these parameters was higher in GN42 than in GN121. Subsequently, a more complete genome annotation was obtained by correcting with the data sequenced on Illumina HiSeq X 10 and PacBio RSII SMRT platform. A total of 6,182 and 5,270 differentially expressed genes (DEGs) were identified in GN121 and GN42, respectively. The majority of these DEGs were involved in phosphorus metabolism such as phospholipid degradation, hydrolysis of phosphoric enzymes, sucrose synthesis, phosphorylation/dephosphorylation and post-transcriptional regulation; expression of these genes was significantly different between GN121 and GN42. Specifically, six and seven DEGs were annotated as phosphorus transporters in roots and leaves, respectively. Furthermore, a putative model was constructed relying on key metabolic pathways related to phosphorus to illustrate the higher phosphorus efficiency of GN121 compared to GN42 under low phosphorus conditions. Results from this study provide a multi-transcriptome database and candidate genes for further study on phosphorus use efficiency (PUE).