Miracle-dz/UniFAR-FTUs huggingface dataset:
Inflammation and Acute Phase Proteins in Haemostasis

Inflammation is a very complex reaction to infection or injury the endeavour being to contain the infection and harm to a limited area. The process is associated with the activation of the coagulation system. To think that inflammation occurs and then leads to activation of the coagulation system is not quite true as there is much cross-talk between the two systems. This is a natural host response to cellular damage or infection however an overshooting of this crosstalk between coagulation and inflammation can lead to an exaggerated prothrombotic state and exacerbate the disease process. A wide range of inflammatory conditions such as infec‐ tions, acute respiratory distress syndrome and SIRS (systemic inflammatory response syn‐ drome) following major surgery e.g.cardiac surgery can lead to an uncontrolled inflammatory response and to profound disturbance of the coagulation system leading to an imbalance in the normal anticoagulated state of blood to that of a procoagulant state. When coagulation is compromised it can contribute to the pathogenesis of the inflammatory condition with deposition of fibrin within the microvasculature directly enhancing the inflammatory reaction. This in turn leads to a modulation of protein manufacture mainly via Liver hepatocytes in the upregulation and downregulation of at least twenty factors directly involved in blood coagulation. This process is controlled via cytokines and leads to the imbalance in what are called the haemostatic acute phase proteins. All of which puts the haemostatic system at an increased thrombotic potential [1, 2, 3, 4].
How have careers changed? An investigation of changing career patterns across four generations

Purpose – Popular literature argues that successive generations are experiencing more job changes and changes of employer. The “new careers” literature also proposes that career mobility patterns are becoming more diverse as people engage in more downward and lateral job changes and changes of occupation. The purpose of this paper is to test these assertions by comparing the career mobility patterns across four generations of workers. Design/methodology/approach – The authors analyzed the career mobility patterns of four generations of Canadian professionals (n=2,555): Matures (born prior to 1946); Baby Boomers (1946-1964); Generation Xers (1965-1979) and Millennials (1980 or later). Job mobility, organizational mobility and the direction of job moves were compared across groups through analysis of variance. Findings – Significant differences were observed in job mobility and organizational mobility of the various generations, with younger generations being more mobile. However, despite significant enviro.
‘Ethnics’ and ‘Anglos’ in the Labour Force: Advancing Australia Fair?

Multiculturalism as ideology and policy has been criticised for over-focusing on cultural identities and differences and a lack of focus on the structural inequality of ethno-cultural groups. This paper focuses on the latter issue through a comparative analysis of the workforce integration of immigrants to Australia. Past research has shown that non-English-speaking-background (NESB) immigrants were worse off than both the Australia-born and English-speaking-background (ESB) immigrants in achieving a job status and income corresponding to their educational qualifications. The paper compares 2006 Census data on education level, type of job, length of residence and English proficiency for eight NESB groups, one ESB group (UK) and the Australia-born. The investigation focuses on how well different birthplace groups are able to translate their skills into appropriate jobs, when controlling for English proficiency and length of residence. The main finding confirms that NESB immigrants still have worse employment outcomes than the Australia-born and UK-born overall, but some NESB groups match the success of the Anglophone groups in vocational sector employment. Among the tertiary educated, the employment outcomes of the Australia-born are better than those of all immigrant groups, closely followed by the UK-born and two other European groups.
Should individual fitness increase with heterozygosity?

Natural selection influences not only gamete frequencies in populations but also the multilocus fitness structures associated with segregating gametes. In particular, only certain patterns of multilocus fitnesses are consistent with the maintenance of stable multilocus polymorphisms. This paper offers support for the proposition that, at stable, viability-maintained, multilocus polymorphisms, the fitness of a genotype tends to increase with the number of heterozygous loci it contains. Average fitness always increases with heterozygosity at stable product equilibria (i.e., those without linkage disequilibrium) maintained by either additive or multiplicative fitness schemes. Simulations suggest that it "generally" increases for arbitrary fitness schemes. The empirical literature correlating allozyme heterozygosity with fitness-correlated traits is discussed in the light of these and other theoretical results.
High stakes lies: police and non-police accuracy in detecting deception

To date, the majority of investigations into accuracy in detecting deception has used low-stakes lies as stimulus materials, and findings from these studies suggest that people are generally poor at detecting deception. The research presented here utilised real-life, high-stakes lies as stimulus materials, to investigate the accuracy of police and non-police observers in detecting deception. It was hypothesised that both police and non-police observers would achieve above chance levels of accuracy in detecting deception, that police officers would be more accurate at detecting deception than non-police observers, that confidence in veracity judgements would be positively related to accuracy and that consensus judgements would predict veracity. One hundred and seven observers (70 police officers and 37 non-police participants) watched 36 videos of people lying or telling the truth in an extremely high-stakes, real-life situation. Police observers achieved mean accuracy in detecting deception of 72%, non-police observers achieved 68% mean accuracy, and confidence in veracity judgements was positively related to accuracy. Consensus judgements correctly predicted veracity in 92% of cases.
Feminist Educational Leadership: Locating the concepts in practice

This article describes a qualitative study of the feminist educational leadership of three co-educational secondary school principals in New Zealand. The findings showed that while each of the women was committed to many of the same ideals, such as leading for social justice, how each went about and achieved that was unique and dependent upon their individual value systems and the cultural and socio-economic mix of the student body they were working with. The women were not passive reactors to the demands of political and school community forces. Rather, they were active and creative in constructing their own feminist leadership practice to effectively meet the needs of their students.
Transnational teaching experiences: an under‐explored territory for transformative professional development

In an increasingly global higher education environment, many universities are taking their educational services overseas. One model of overseas provision is through transnational (offshore) education. Transnational teaching challenges the prevailing understanding of an academic role at every level. Transnational teachers are expected to work in environments, climates and classrooms which are culturally very different to their own. Assumptions about university education are shaken and teachers find themselves having to return to and question the fundamentals of their teaching, learning and assessment practices. This paper argues that the experience of being a transnational teacher and working in a culture very different to one’s own forces reflection which can lead to ‘perspective transformation’; as such it could be a powerful professional development opportunity which should be nurtured and supported. This paper draws on the growing body of published literature on staff experiences of transnational teaching and my own experiences as a transnational teacher to support this argument. It shows that the ‘novel experiences’ of transnational teaching encourage content, process and premise reflection that can, with appropriate support, ultimately improve teaching practice not just in the transnational context, but also back home. Dans un environnement de l’enseignement supérieur de plus en plus globalisé, nombre d’universités étendent leur prestation de services éducatifs outremer. L’éducation transnationale délocalisée (offshore education) est un de ces modèles de prestation de services outremer. L’enseignement transnational pose des défis à la compréhension dominante du rôle académique à tous les niveaux. Les présupposés au sujet de l’éducation universitaire sont remis en question et les enseignants doivent dès lors revoir et remettre en question les fondements de leurs pratiques liées à l’enseignement, à l’apprentissage et à l’évaluation. Cet article défend l’idée que l’expérience de devenir un enseignant transnational et d’œuvrer dans une culture qui est très différente de la sienne force une réflexion qui peut conduire à une « transformation de perspective ». En ce sens, il pourrait s’agir d’une occasion de développement professionnel puissante, laquelle devrait être soutenue et encouragée. L’article repose sur un corpus de documentation en pleine croissance portant sur l’enseignement transnational ainsi que sur mes propres expériences à titre d’enseignement transnational. Il fait la démonstration que des « expériences nouvelles » de l’enseignement transnational encouragent une réflexion au sujet du contenu, du processus et des présupposés, laquelle, en fonction d’un soutien adapté, peut en fin de compte améliorer la pratique enseignante non seulement dans le contexte transnational mais aussi à domicile.
Visualization of NO3−/NO2− Dynamics in Living Cells by Fluorescence Resonance Energy Transfer (FRET) Imaging Employing a Rhizobial Two-component Regulatory System*♦

Nitrate (NO3−) and nitrite (NO2−) are the physiological sources of nitric oxide (NO), a key biological messenger molecule. NO3−/NO2− exerts a beneficial impact on NO homeostasis and its related cardiovascular functions. To visualize the physiological dynamics of NO3−/NO2− for assessing the precise roles of these anions, we developed a genetically encoded intermolecular fluorescence resonance energy transfer (FRET)-based indicator, named sNOOOpy (sensor for NO3−/NO2− in physiology), by employing NO3−/NO2−-induced dissociation of NasST involved in the denitrification system of rhizobia. The in vitro use of sNOOOpy shows high specificity for NO3− and NO2−, and its FRET signal is changed in response to NO3−/NO2− in the micromolar range. Furthermore, both an increase and decrease in cellular NO3− concentration can be detected. sNOOOpy is very simple and potentially applicable to a wide variety of living cells and is expected to provide insights into NO3−/NO2− dynamics in various organisms, including plants and animals.
Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognoses.

We studied the status of chromosomes 1 and 19 in 363 astrocytic and oligodendroglial tumors. Whereas the predominant pattern of copy number abnormality was a concurrent loss of the entire 1p and 19q regions (total 1p/19q loss) among oligodendroglial tumors and partial deletions of 1p and/or 19q in astrocytic tumors, a subset of apparently astrocytic tumors also had total 1p/19q loss. The presence of total 1p/19q loss was associated with longer survival of patients with all types of adult gliomas independent of age and diagnosis (P = .041). The most commonly deleted region on 19q in astrocytic tumors spans 885 kb in 19q13.33-q13.41, which is telomeric to the previously proposed region. Novel regions of homozygous deletion, including a part of DPYD (1p21.3) or the KLK cluster (19q13.33), were observed in anaplastic oligodendrogliomas. Amplifications encompassing AKT2 (19q13.2) or CCNE1 (19q12) were identified in some glioblastomas. Deletion mapping of the centromeric regions of 1p and 19q in the tumors that had total 1p/19q loss, indicating that the breakpoints lie centromeric to NOTCH2 within the pericentromeric regions of 1p and 19q. Thus, we show that the copy number abnormalities of 1p and 19q in human gliomas are complex and have distinct patterns that are prognostically predictive independent of age and pathological diagnosis. An accurate identification of total 1p/19q loss and discriminating this from other 1p/19q changes is, however, critical when the 1p/19q copy number status is used to stratify patients in clinical trials.
Boundedness of sublinear operators on product Hardy spaces and its application

Let $p\in(0, 1]$. In this paper, the authors prove that a sublinear operator $T$ (which is originally defined on smooth functions with compact support) can be extended as a bounded sublinear operator from product Hardy spaces $H^p({{\mathbb R}^n\times{\mathbb R}^m})$ to some quasi-Banach space ${\mathcal B}$ if and only if $T$ maps all $(p, 2, s_1, s_2)$-atoms into uniformly bounded elements of ${\mathcal B}$. Here $s_1\ge\lfloor n(1/p-1)\rfloor$ and $s_2\ge\lfloor m(1/p-1)\rfloor$. As usual, $\lfloor n(1/p-1)\rfloor$ denotes the maximal integer no more than $n(1/p-1)$. Applying this result, the authors establish the boundedness of the commutators generated by Calder\'on-Zygmund operators and Lipschitz functions from the Lebesgue space $L^p({{\mathbb R}^n\times{\mathbb R}^m})$ with some $p>1$ or the Hardy space $H^p({{\mathbb R}^n\times{\mathbb R}^m})$ with some $p\le1$ but near 1 to the Lebesgue space $L^q({{\mathbb R}^n\times{\mathbb R}^m})$ with some $q>1$.
Quantification of duodenogastric reflux in Barrett's esophagus.

OBJECTIVES Our objective was to assess the role of reflux of duodenal contents in the genesis of Barrett's esophagus. Therefore, we performed a study to quantify duodenogastric reflux, using 99mTc-HIDA quantification in gastric juice after continuous intravenous infusion of the same. METHODS The study contained 20 patients with Barrett's esophagus (10 uncomplicated and 10 complicated by ulcers and/or stenosis), 10 patients with peptic esophagitis without Barrett's esophagus (two grade I, four grade II, and four grade III, according to Savary-Miller), and 10 healthy volunteers who made up the control group. Comparisons were made between the groups. RESULTS When we considered the groups overall, we observed that the 20 patients with Barrett's esophagus had higher reflux rates (p < 0.01) than either the 10 patients with peptic esophagitis without Barrett's esophagus, or the 10 controls. Complicated Barrett's esophagus presented higher reflux rates than uncomplicated Barrett's esophagus, although the differences were not statistically significant. However, on analyzing the results after considering the groups case by case, we see that the mean reflux rate in the Barrett's esophagus groups is due to five patients presenting much higher rates than the rest. CONCLUSIONS Our results suggest that duodenogastric reflux might be involved in the appearance of Barrett's esophagus and its related complications, although only in certain cases. The pathogenesis of Barrett's esophagus is probably multifactorial, and other factors must be involved.
Olfactory memory formation and the influence of reward pathway during appetitive learning by honey bees

SUMMARY Animals possess the ability to assess food quality via taste and via changes in state that occur after ingestion. Here, we investigate the extent to which a honey bee's ability to assess food quality affected the formation of association with an odor stimulus and the retention of olfactory memories associated with reward. We used three different conditioning protocols in which the unconditioned stimulus (food) was delivered as sucrose stimulation to the proboscis (mouthparts), the antennae or to both proboscis and antennae. All means of delivery of the unconditioned stimulus produced robust associative conditioning with an odor. However, the memory of a conditioned odor decayed at a significantly greater rate for subjects experiencing antennal-only stimulation after either multiple- or single-trial conditioning. Finally, to test whether the act of feeding on a reward containing sucrose during conditioning affected olfactory memory formation, we conditioned honey bees to associate an odor with antennal stimulation with sucrose followed by feeding on a water droplet. We observed that a honey bee's ability to recall the conditioned odor was not significantly different from that of subjects conditioned with an antennal-only sucrose stimulus. Our results show that stimulation of the sensory receptors on the proboscis and/or ingestion of the sucrose reward during appetitive olfactory conditioning are necessary for long-term memory formation.
Reduced-complexity techniques for indoor map-aware localization

In this manuscript new reduced complexity localization algorithms exploiting received signal strength measurements and based on the indoor map-aware statistical models illustrated in [1] are developed. Such algorithms exploit search domain reduction techniques and state of the art methods for numerical integration and optimization. Our numerical and experimental results evidence that theirs accuracy is very close to that offered by their optimal counterparts, in spite of their substantially lower computational complexity.
Expression of Ets‐1 transcription factor is correlated with penetrating tumor progression in patients with squamous cell carcinoma of the esophagus

The Ets‐1 transcription factor is proposed to play a role in tumor invasion. To evaluate the biologic significance of Ets‐1 in the progression of squamous cell carcinoma of the esophagus, the authors investigated Ets‐1 expression in tumors from 90 patients using immunohistochemical procedures.
Dyslexia and AD/HD among Swedish Prison Inmates

The aim of this study was to replicate previous findings of an increased frequency of reading and writing disabilities among prison inmates in Sweden and Norway. Furthermore, we wanted to look into the comorbidity of AD/HD and dyslexia and their correlates, i.e. the extent to which the individuals had multiple problems and satisfied criteria for more than one psychiatric disorder. Forty-five inmates with Swedish as native language, age 21-52 years, were examined with interviews, academic achievement neuropsychological and personality questionnaires. Twenty-eight (62%) were diagnosed with dyslexia, in line with our previous study. Childhood hyperactivity was reported by 25 of the inmates (55%) and persisted into adulthood for half of these subjects. No differences between the dyslexic vs nondyslexic inmates regarding personality disorders were observed. The previously obtained socially deviant personality pattern among AD/HD inmates was assessment tests, replicated. When controlling for comorbid AD/HD only one (of 15) personality traits covaried with dyslexia: suspicion. Thus, a substantial number of Swedish prison inmates have reading and writing difficulties as well as AD/HD. There are unmet needs for early diagnoses of neuropsychiatric problems among juveniles at risk, and for remediation of these difficulties among prison inmates.
Enterobacter bacteremia in pediatric patients.

Enterobacter has emerged as an important human pathogen, particularly in sick, hospitalized patients. Previous reports of nonepidemic enterobacter bacteremia have focused on adult patients. In this report, the epidemiologic factors, clinical characteristics, treatment, and outcome for 33 patients with enterobacter bacteremia in a large children's hospital during a 5-year period are reviewed. The ratio of males to females was 1.2:1. The patients' ages ranged from 2 days to 24 years, and 18 patients were less than 18 months old. Twenty-two cases were nosocomially acquired; six were polymicrobial in nature. Significantly underlying conditions were present in 32 patients. The biliary tract and central venous catheters were the most common sources of bacteremia. Two-thirds of patients had preceding antibiotic therapy. The overall mortality was 24%; mortality attributable to enterobacter bacteremia was 18%. Statistically significant differences in mortality were associated with an age less than 18 months (P = .031) or thrombocytopenia (P = .017); presence of fever was of borderline significance (P = .098). Enterobacter bacteremia is an important cause of morbidity and mortality in pediatric patients.
Public health pedagogy, border crossings and physical activity at every size

This paper examines the current weight-centric approach to the promotion and practice of physical activity for health. We argue that examining the assumptions and belief systems that drive physical activity promotion may provide a foundation for considering and pursuing appropriate forms of social change in the policy, prescription and practice fields. Counter perspectives and critical voices offering alternative health paradigms are systematically marginalised or silenced in this discourse. We outline the significance of a public pedagogy approach in developing alternative ways of promoting, representing and experiencing physical activity beyond weight focused perspectives. We advocate that physical activity policy makers and practitioners, including those promoting a non weight-centric approach to health need to undertake ‘border crossing’ and work across ‘artificial’ institutional barriers. The paper discusses the principles of a non-weight based, cross-disciplinary Health at Every Size (HAES) approach. It presents a critical examination of the potentials of harnessing a HAES paradigm as an alternative to a weight-loss focused physical activity intervention. At the same time, it argues that even this approach needs to better address the complexities of weight rather than search for singular, universal responses to the problems of healthism.
Regulation of Gonadotropin-Releasing Hormone Gene Expressionin Vivoandin Vitro


The pulsatile release of gonadotropin-releasing hormone (GnRH) into the portal vasculature is responsible for the maintenance of reproductive function. Levels of GnRH decapeptide available for this process can be regulated at transcriptional, posttranscriptional, and posttranslational levels. In the immortalized neuronal GT1 cell lines which synthesize and secrete GnRH, regulation of GnRH biosynthesis has been studied using activators of the protein kinase A (PKA), protein kinase C (PKC), and calcium second messenger systems. These substances, while stimulating GnRH release, cause a universal inhibition of all biosynthetic indices measured to date, including decreases in transcription of the proGnRH gene, GnRH mRNA levels, mRNA stability, and translational efficiency. In contrast, in the animal, the mechanism for the regulation of GnRH gene expression appears to be primarily posttranscriptional, since changes in GnRH mRNA levels often occur in the absence of changes in GnRH primary transcript levels an index of GnRH gene transcription. For example, GnRH mRNA levels increase in response to stimulation with glutamate analogs, while GnRH primary transcript levels are unchanged. However, parallel changes in GnRH mRNA and primary transcript have been observed on proestrus prior to the LH/GnRH surge, suggesting that the regulation of GnRH mRNA levels in vivo involves a complex interplay of transcriptional and posttranscriptional processes.