Miracle-dz/UniFAR-FTUs huggingface dataset:
Evolution of the Intergalactic Opacity: Implications for the Ionizing Background, Cosmic Star Formation, and Quasar Activity

We investigate the implications of the intergalactic opacity for the evolution of the cosmic UV luminosity density and its sources. Our main constraint is our measurement of the Lyα forest opacity at redshifts 2 ⩽ z ⩽ 4.2 from 86 high-resolution quasar spectra. In addition, we impose the requirements that H I must be reionized by z = 6 and He II by z ∼ 3 and consider estimates of the hardness of the ionizing background from H I-to-He II column density ratios. The derived hydrogen photoionization rate is remarkably flat over the Lyα forest redshift range covered. Because the quasar luminosity function is strongly peaked near z ∼ 2, the lack of redshift evolution indicates that star-forming galaxies likely dominate the photoionization rate at z ≳ 3. Combined with direct measurements of the galaxy UV luminosity function, this requires only a small fraction fesc ∼ 0.5% of galactic hydrogen-ionizing photons to escape their source for galaxies to solely account for the entire ionizing background. Under the assumption that the galactic UV emissivity traces the star formation rate, current state-of-the-art observational estimates of the star formation rate density appear to underestimate the total photoionization rate at z ∼ 4 by a factor of ~4, are in tension with recent determinations of the UV luminosity function, and fail to reionize the universe by z ∼ 6 if extrapolated to arbitrarily high redshift. A theoretical star formation history peaking earlier fits the Lyα forest photoionization rate well, reionizes the universe in time, and is in better agreement with the rate of z ∼ 4 gamma-ray bursts observed by Swift. Quasars suffice to doubly ionize helium by z ∼ 3 and likely contribute a nonnegligible and perhaps dominant fraction of the hydrogen-ionizing background at their z ∼ 2 peak.
Standard Error Estimation of 3PL IRT True Score Equating With an MCMC Method

A Markov chain Monte Carlo (MCMC) method and a bootstrap method were compared in the estimation of standard errors of item response theory (IRT) true score equating. Three test form relationships were examined: parallel, tau-equivalent, and congeneric. Data were simulated based on Reading Comprehension and Vocabulary tests of the Iowa Tests of Basic Skills®. For parallel and congeneric test forms within valid IRT true score ranges, the pattern and magnitude of standard errors of IRT true score equating estimated by the MCMC method were very close to those estimated by the bootstrap method. For tau-equivalent test forms, the pattern of standard errors estimated by the two methods was also similar. Bias and mean square errors of equating produced by the MCMC method were smaller than those produced by the bootstrap method; however, standard errors were larger. In educational testing, the MCMC method may be used as an additional or alternative procedure to the bootstrap method when evaluating the precision of equating results.
A fast and versatile path index for querying semi-structured data

The richness of semi-structured data allows data of varied and inconsistent structures to be stored in a single database. Such data can be represented as a graph, and queries can be constructed using path expressions, which describe traversals through the graph. Instead of providing optimal performance for a limited range of path expressions, we propose a mechanism which is shown to have consistent and high performance for path expressions of any complexity, including those with descendant operators (path wildcards). We further detail mechanisms which employ our index to perform more complex processing, such as evaluating both path expressions containing links and entire (sub) queries containing path based predicates. Performance is shown to be independent of the number of terms in the path expression, even where these contain wildcards. Experiments show that our index is faster than conventional methods by up to two orders of magnitude for certain query types, is small, and scales well.
Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line.

Development of an estrogen receptor-mediated, chemical-activated luciferase reporter gene-expression (ER-CALUX) assay was attempted by stable transfection of luciferase reporter genes in a number of cell lines. Stable transfection of the chimeric Gal4 estrogen receptor and luciferase gene constructs in MCF-7 breast cancer and Hepa.1c1c7 mouse hepatoma cell lines, as well as transfection of a newly constructed luciferase reporter gene pEREtata-Luc in the ECC-1 human endometrial cell line, resulted in constitutive, non-estradiol-inducible clones. Stable transfection of pEREtata-Luc in the T47D breast cancer cell line, however, resulted in an extremely sensitive, highly responsive cell line. Following a 24-h exposure to estradiol (E2), stably transfected T47D.Luc cells demonstrated a detection limit of 0.5 pM, an EC50 of 6 pM, and a maximum induction of 100-fold relative to solvent controls. No clear reduction in responsiveness has been found over extended culture periods (50 passages). Anti-estrogens ICI 182,780, TCDD, and tamoxifen inhibited the estradiol-mediated luciferase induction. Genistein, nonylphenol, and o,p'DDT were the most potent (pseudo-)estrogens tested in this system (EC50 100, 260, and 660 nM, respectively). Determination of interactive effects of the (pseudo-)estrogens nonylphenol, o,p'DDT, chlordane, endosulfan, dieldrin, and methoxychlor revealed that, in combination with 3 pM E2, (pseudo-)estrogens were additive. Slightly more than additive effects (less than 2-fold) were found for combinations of dieldrin and endosulfan tested in the range of 3 to 6 microM. At these concentrations, the combination of endosulfan and chlordane demonstrated additive interaction. The ER-CALUX assay with T47D cells can provide a sensitive, responsive, and rapid in vitro system to detect and measure substances with potential (anti-)estrogenic activity.
Delays and Factors Related to Cessation of Generalized Convulsive Status Epilepticus

Introduction. This study was designed to identify the delays and factors related to and predicting the cessation of generalized convulsive SE (GCSE). Methods. This retrospective study includes 70 consecutive patients (>16 years) diagnosed with GCSE and treated in the emergency department of a tertiary hospital over 2 years. We defined cessation of SE stepwise using clinical seizure freedom, achievement of burst-suppression, and return of consciousness as endpoints and calculated delays for these cessation markers. In addition 10 treatment delay parameters and 7 prognostic and GCSE episode related factors were defined. Multiple statistical analyses were performed on their relation to cessation markers. Results. Onset-to-second-stage-medication (p = 0.027), onset-to-burst-suppression (p = 0.005), and onset-to-clinical-seizure-freedom (p = 0.035) delays correlated with the onset-to-consciousness delay. We detected no correlation between age, epilepsy, STESS, prestatus period, type of SE onset, effect of the first medication, and cessation of SE. Conclusion. Our study demonstrates that rapid administration of second-stage medication and early obtainment of clinical seizure freedom and burst-suppression predict early return of consciousness, an unambiguous marker for the end of SE. We propose that delays in treatment chain may be more significant determinants of SE cessation than the previously established outcome predictors. Thus, streamlining the treatment chain is advocated.
Stability of fuzzy control systems with bounded uncertain delays

Global exponential stability of fuzzy control systems with delays is studied. These delays in the fuzzy control systems are assumed to be any uncertain bounded continuous functions. Stability of systems with uncertain delays is interesting since in practical applications it is not easy to know the delays exactly. Conditions for global exponential stability of free fuzzy systems with uncertain delays are derived. Criteria for design of nonlinear fuzzy controllers to feedback control the stability of global nonlinear fuzzy systems are given. Theorems are proved via the method of functional differential inequalities analysis.
Analyzing Aviation Safety Reports: From Topic Modeling to Scalable Multi-Label Classification

The Aviation Safety Reporting System (ASRS) is used to collect voluntarily submitted aviation safety reports from pilots, controllers and others. As such it is particularly useful in researching aviation safety deficiencies. In this paper we address two challenges related to the analysis of ASRS data: (1) the unsupervised extraction of meaningful and interpretable topics from ASRS reports and (2) multi-label classification of ASRS data based on a set of predefined categories. For topic modeling we investigate the practical usefulness of Latent Dirichlet Allocation (LDA) when it comes to modeling ASRS reports in terms of interpretable topics. We also utilize LDA to generate a more compact representation of ASRS reports to be used in multi-label classification. For multi-label classification we propose a novel and highly scalable multi-label classification algorithm based on multi-variate regression. Empirical results indicate that our approach is superior to several baseline and state-of-the-art approaches.
Open Surgical versus Minimal Invasive Necrosectomy of the Pancreas—A Retrospective Multicenter Analysis of the German Pancreatitis Study Group

Background Necrotising pancreatitis, and particularly infected necrosis, are still associated with high morbidity and mortality. Since 2011, a step-up approach with lower morbidity rates compared to initial open necrosectomy has been established. However, mortality and complication rates of this complex treatment are hardly studied thereafter. Methods The German Pancreatitis Study Group performed a multicenter, retrospective study including 220 patients with necrotising pancreatitis requiring intervention, treated at 10 hospitals in Germany between January 2008 and June 2014. Data were analysed for the primary endpoints "severe complications" and "mortality" as well as secondary endpoints including "length of hospital stay", "follow up", and predisposing or prognostic factors. Results Of all patients 13.6% were treated primarily with surgery and 86.4% underwent a step-up approach. More men (71.8%) required intervention for necrotising pancreatitis. The most frequent etiology was biliary (41.4%) followed by alcohol (29.1%). Compared to open necrosectomy, the step-up approach was associated with a lower number of severe complications (primary composite endpoint including sepsis, persistent multiorgan dysfunction syndrome (MODS) and erosion bleeding: 44.7% vs. 73.3%), lower mortality (10.5% vs. 33.3%) and lower rates of diabetes mellitus type 3c (4.7% vs. 33.3%). Low hematocrit and low blood urea nitrogen at admission as well as a history of acute pancreatitis were prognostic for less complications in necrotising pancreatitis. A combination of drainage with endoscopic necrosectomy resulted in the lowest rate of severe complications. Conclusion A step-up approach starting with minimal invasive drainage techniques and endoscopic necrosectomy results in a significant reduction of morbidity and mortality in necrotising pancreatitis compared to a primarily surgical intervention.
Can Sadness Be Good for You?: On the Cognitive, Motivational, and Interpersonal Benefits of Mild Negative Affect

The subtle relationship between feeling and thinking, affect and cognition has fascinated philosophers and writers since time immemorial, yet, empirical research on this topic was relatively neglected by psychologists until recently. There have been many claims emphasising the beneficial cognitive and behavioural consequences of positive affect. Many recent works suggest that negative affect may also facilitate optimal performance in many situations, consistent with evolutionary theories suggesting the adaptive signalling function of various affective states. This paper reviews traditional and current psychological theories linking affect to social thinking and behaviour. A variety of empirical studies from our laboratory will also be presented, demonstrating that in many situations, negative affect promotes optimal performance in cognitive and social tasks, including tasks such as memory, social judgements, motivation, and strategic interpersonal behaviours. These results will be interpreted in terms of a dual‐process theory that predicts that negative affect promotes a more accommodative, vigilant, and externally focused thinking strategy. The relevance of these findings for recent affect–cognition theories will be discussed, and the practical implications of negative affect promoting improved social thinking and performance in a number of applied fields will be considered.
Wall-layer models for large-eddy simulations

The numerical simulation of high Reynolds number flows is hampered by model accuracy if the Reynolds-averaged Navier–Stokes (RANS) equations are used, and by computational cost if direct or large-eddy simulations (LES) that resolve the near-wall layer are employed. The cost of a calculation scales like the Reynolds number to the power 3 for direct numerical simulations, or 2.4 for LES, making the resolution of the wall layer at high Reynolds number infeasible even with the most advanced computers. In LES, an attractive alternative to compute high-Re flows is the use of wall-layer models, in which only the outer layer is resolved, while the near-wall region is modeled. Three broad classes of approaches are presently used: bypassing this region altogether using wall functions, solving a separate set of equations in the near-wall region, weakly coupled to the outer flow, or simulating the near-wall region in a global, Reynolds-averaged, sense. These approaches are discussed and their ranges of applicability are highlighted. Various unresolved issues in wall-layer modeling are presented.
Institutionalism: On the Need to Firm up Notions of Social Structure and the Human Subject

Within (old) institutionalist theorizing there has been a widespread tendency for institutions and technology to be treated in a somewhat dichotomous fashion, with the former regarded as synonymous with constraint, rigidity, or stasis and the latter associated with change and dynamics. Very often this dichotomy is associated with Thorstein Veblen (being referred to as the "Veblen dichotomy") even though on close scrutiny of Veblen's texts it is easy enough to find commentaries seemingly at odds with it. Reliance upon the dichotomy in question has been most apparent within the dominant North American strand of institutionalist thinking, with some contributors even prepared to argue that it constitutes the tradition's central analytic tool or defining core (see, e.g., Waller 1982; Munkirs 1988; Klein and Miller 1996). However, not all institutionalists have accepted the dichotomy as formulated, even within the North American movement. Indeed in recent years, especially,l there appears to be a significant amount of dissent within this grouping (see, e.g., Ramstad 1995; Wisman and Smith 1999) as well as endeavor to reformulate aspects of the dichotomy (see, e.g., Tool 1979; Miller 1992; Bush 1987, 1989; Waller 1987; Dugger 1995). I think it is fair to say, though, that most dissenters and reformers have rested content largely with identifying substantive limitations of the dichotomy as traditionally formulated or else with questioning the legitimacy of associating it with Veblen. Rather less effort, it seems to me, has been directed to explaining the widespread acceptance of the dichotomy within the institutionalist tradition or for the commonplace association of it with Veblen. Here I want to focus on these latter two issues in particular, starting with the question of why the dichotomy has emerged and been as widely accepted as it has. I believe
Attention Performance Measured by Attention Network Test Is Correlated with Global and Regional Efficiency of Structural Brain Networks

Functional neuroimaging studies have indicated the involvement of separate brain areas in three distinct attention systems: alerting, orienting, and executive control (EC). However, the structural correlates underlying attention remains unexplored. Here, we utilized graph theory to examine the neuroanatomical substrates of the three attention systems measured by attention network test (ANT) in 65 healthy subjects. White matter connectivity, assessed with diffusion tensor imaging deterministic tractography was modeled as a structural network comprising 90 nodes defined by the automated anatomical labeling (AAL) template. Linear regression analyses were conducted to explore the relationship between topological parameters and the three attentional effects. We found a significant positive correlation between EC function and global efficiency of the whole brain network. At the regional level, node-specific correlations were discovered between regional efficiency and all three ANT components, including dorsolateral superior frontal gyrus, thalamus and parahippocampal gyrus for EC, thalamus and inferior parietal gyrus for alerting, and paracentral lobule and inferior occipital gyrus for orienting. Our findings highlight the fundamental architecture of interregional structural connectivity involved in attention and could provide new insights into the anatomical basis underlying human behavior.
UvA-DARE ( Digital Academic Repository ) Pooling Objects for Recognizing Scenes without Examples

In this paper we aim to recognize scenes in images without using any scene images as training data. Different from attribute based approaches, we do not carefully select the training classes to match the unseen scene classes. Instead, we propose a pooling over ten thousand of off-the-shelf object classifiers. To steer the knowledge transfer between objects and scenes we learn a semantic embedding with the aid of a large social multimedia corpus. Our key contributions are: we are the first to investigate pooling over ten thousand object classifiers to recognize scenes without examples; we explore the ontological hierarchy of objects and analyze the influence of object classifiers from different hierarchy levels; we exploit object positions in scene images and we demonstrate new scene retrieval scenarios with complex queries. Finally, we outperform attribute representations on two challenging scene datasets, SUNAttributes and Places2.
Nonstranger Victimization and Inmate Maladjustment

Scholars have hypothesized that victimization elicits distinctive effects on women’s pathways to prison and subsequent prison maladjustment, but few researchers have investigated gender differences in this relationship. Using nationally representative samples of men and women housed in state prisons, we examine gender differences in the effects of experiencing different types of nonstranger victimization prior to prison on inmate maladjustment. Results indicate that pre-prison nonstranger victimization affects men’s and women’s maladjustment similarly, with some gender differences—specifically, the effect of being physically assaulted by a nonstranger as an adult on violent misconduct was stronger among men, as was the effect of child abuse on men’s depressive symptoms. Our findings suggest the effects of experiencing nonstranger victimization prior to incarceration on prison maladjustment may be gender-neutral more so than gender-specific. Based on our findings, nonstranger victimization should be deemed important in theories of men’s maladjustment as well as in theories of women’s maladjustment.
Mapping Composition for Matching Large Life Science Ontologies

There is an increasing need to interrelate different life science ontologies in order to facilitate data integration or semantic data analysis. Ontology matching aims at a largely automatic generation of mappings between ontologies mostly by calculating the linguistic and structural similarity of their concepts. In this paper we investigate an indirect computation of ontology mappings that composes and thus reuses previously determined ontology mappings that involve intermediate ontologies. The composition approach promises a fast computation of new mappings with reduced manual effort. Our evaluation for large anatomy ontologies shows that composing mappings via intermediate hub ontologies is not only highly efficient but can also achieve better match quality than with a direct matching of ontologies.
Separability and Eciency for Generic Group Signature Schemes (Extended Abstract)

A cryptographic protocol possesses separability if the par- ticipants can choose their keys independently of each other. This is ad- vantageous from a key-management as well as from a security point of view. This paper focuses on separability in group signature schemes. Such schemes allow a group member to sign messages anonymously on the group's behalf. However, in case of this anonymity's misuse, a trustee can reveal the originator of a signature. We provide a generic fully separa- ble group signature scheme and present an ecient instantiation thereof. The scheme is suited for large groups; the size of the group's public key and the length of signatures do not depend on the number of group member. Its eciency is comparable to the most ecient schemes that do not oer separability and is an order of magnitude more ecient than a previous scheme that provides partial separability. As a side result, we provide ecient proofs of the equality of two discrete logarithms from dierent groups and, more general, of the validity of polynomial relations in among discrete logarithms from dierent groups.
Democracy and the demographic transition

ABSTRACT This article addresses the role of demographic factors in contributing to the emergence of democracy. It maintains that, other things being equal, progress in the demographic transition promotes democratization. The argument is developed with reference to the effects of interrelated changes in mortality, natural increase (i.e. population growth), fertility, and population age structure. Suggestions are also made with respect to how demographic and democratic trends should be gauged. An analysis of data for the period 1970–2005 for 77 countries that were initially non-democratic provides substantial support for the argument. Some implications are discussed, as are future trends in democratization from a demographer’s perspective.