Miracle-dz/UniFAR-FTUs huggingface dataset:
WESPE: Weakly Supervised Photo Enhancer for Digital Cameras

Low-end and compact mobile cameras demonstrate limited photo quality mainly due to space, hardware and budget constraints. In this work, we propose a deep learning solution that translates photos taken by cameras with limited capabilities into DSLR-quality photos automatically. We tackle this problem by introducing a weakly supervised photo enhancer (WESPE) - a novel image-to-image Generative Adversarial Network-based architecture. The proposed model is trained by under weak supervision: unlike previous works, there is no need for strong supervision in the form of a large annotated dataset of aligned original/enhanced photo pairs. The sole requirement is two distinct datasets: one from the source camera, and one composed of arbitrary high-quality images that can be generally crawled from the Internet - the visual content they exhibit may be unrelated. In this work, we emphasize on extensive evaluation of obtained results. Besides standard objective metrics and subjective user study, we train a virtual rater in the form of a separate CNN that mimics human raters on Flickr data and use this network to get reference scores for both original and enhanced photos. Our experiments on the DPED, KITTI and Cityscapes datasets as well as pictures from several generations of smartphones demonstrate that WESPE produces comparable or improved qualitative results with state-of-the-art strongly supervised methods.
A framework of wound segmentation based on deep convolutional networks

Quantification of the chronic wound size is important in clinical wound treatment as the care for each individual patient is largely based on this assessment. Recently, clinicians usually measure wound area using standardized scale mainly based on visual inspection, which is often subjective and potentially inaccurate. Unfortunatly, automated segmentation of wound area is a challenge task owing to the diverse wound characteristics and the haziness over where wound boundaries lie. To address this problem, we propose a deep convolutional networks based framework named WoundSeg to locate and segment wound areas automatically. Firstly, we establish a newly annotated dataset containing 950 digital images of different chronic wounds, and propose an annotation tool based on watershed algorithm to mask wound regions conveniently for expert clinicians. Then, a light-weight network is built specifically for wound segmentation with limited training data. Finally, morphology operation and skin detection based verification are used to postprocess the predictions of the network. We estimate the generalization error of WoundSeg with 5-fold cross-validation on the above dataset and also on various latest clinic images taken of patients at the wound clinic. Extensive experiments demonstrate the efficiency and effectiveness of the proposed framework which can be considered as a promising approach to replace empirical and imprecise manual measurement for wound areas.
Electrical and Lightning Injuries

The aim of this study was to explore the mechanisms, complications, morbidity, and mortality associated with electrical injuries. Of 5053 acute burn admissions during a 5-year period, 202 patients (4%) had electrical burn injuries. Their mean age was 27.5 years (range, 3–71 years). Ninety-eight percent were male, and the extent of burn ranged from 1% to 70% TBSA (mean, 10.5 ± 10.7% TBSA). High-voltage electricity caused 54% of the electrical injuries. Forty-two percent were caused by low-voltage currents and 4% by lightning. A total of 217 surgical procedures were performed on 202 patients Fifteen patients (7.4%) required amputation. All patients who had abnormal electrocardiograms underwent cardiac monitoring. Four had cardiac complications. Mean hospital stay was 13.9 ± 14.6 days (range, 1–90). Four patients (2%) died. Electrical burn injuries continue to be a serious problem of modern society. Climbing power poles is the most common mechanism for high-voltage injury. Special consideration is required to prevent this type of injury in our region.
Very young women (<35 years) with operable breast cancer: features of disease at presentation.

BACKGROUND Breast cancer rarely occurs in young women. Our knowledge about disease presentation, prognosis and treatment effects are largely dependent upon older series. MATERIALS AND METHODS We evaluated biological features and stage at presentation for 1427 consecutive premenopausal patients aged < or = 50 years with first diagnosis of invasive breast cancer referred to surgery at the European Institute of Oncology from April 1997 to August 2000. A total of 185 patients (13%) were aged < 35 years ('very young') and 1242 (87%) were aged 35-50 years ('less young'). The expression of estrogen receptors (ER), progesterone receptors (PgR), presence of vascular invasion (VI), grading (G), expression of Ki-67, HER2/neu overexpression, pathological stage according to TNM staging system (pTNM), pathological tumor size and number of axillary lymph node involvement were evaluated. RESULTS Compared with less young patients, the very young patient group had a higher percentage of tumors classified as ER negative (P < 0.001), PgR negative (P = 0.001), higher expression of Ki-67 > or = 20% of cells stained; 62.2% versus 53%, (P < 0.001), vascular or lymphatic invasion (48.6% versus 37.3%, P = 0.006), and pathological grade 3 (P < 0.0001). There was no difference between the two groups for pT, pathological tumor size (pN) and number of positive lymph nodes. CONCLUSIONS We conclude that compared with less young premenopausal patients, very young women have a greater chance of having an endocrine-unresponsive tumor, and are more likely to present with a higher grade, more extensively proliferating and vessel invading disease. Pathological tumor size, nodal status and number of positive axillary lymph-nodes have a similar distribution among the younger and the older cohorts, thus not supporting previous data indicating more advanced disease in younger patients at diagnosis of operable disease.
Retracted: High‐speed FSK modulator using switched‐capacitor resonators

The above article, published online on 30 September 2015 in Wiley Online Library (http://www.onlinelibrary.wiley.com), has been retracted by agreement between the journal Editor in Chief, Ángel Rodríguez‐Vázquez, and John Wiley & Sons, Ltd. Following an investigation by the institution of the author, the retraction has been agreed because a co‐author was not informed of the submission and did not provide consent for it to proceed. In addition, the co‐author was not acknowledged in the manuscript itself. The article is to be retracted at the request of the co‐author.
Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during Plasmodium gametogenesis

Malaria transmission relies on the production of gametes following ingestion by a mosquito. Here, we show that Ca2+-dependent protein kinase 4 controls three processes essential to progress from a single haploid microgametocyte to the release of eight flagellated microgametes in Plasmodium berghei. A myristoylated isoform is activated by Ca2+ to initiate a first genome replication within twenty seconds of activation. This role is mediated by a protein of the SAPS-domain family involved in S-phase entry. At the same time, CDPK4 is required for the assembly of the subsequent mitotic spindle and to phosphorylate a microtubule-associated protein important for mitotic spindle formation. Finally, a non-myristoylated isoform is essential to complete cytokinesis by activating motility of the male flagellum. This role has been linked to phosphorylation of an uncharacterised flagellar protein. Altogether, this study reveals how a kinase integrates and transduces multiple signals to control key cell-cycle transitions during Plasmodium gametogenesis. DOI: http://dx.doi. org/10.7554/eLife.26524. 001
Characteristics of lower stratospheric transport as inferred from the age of air spectrum

Abstract. Trace gas transport in the lower stratosphere is investigated by analyzing seasonal and inter-annual variations of the age of air spectrum – the probability distribution of stratospheric transit times. Age spectra are obtained using the Lagrangian transport model CLaMS driven by ERA-Interim winds, and using a boundary-impulse-response method based on multiple tracer pulses. Seasonal age spectra show large deviations from an idealized stationary unimodal shape. Multiple modes emerge in the spectrum throughout the stratosphere, strongest at high latitudes, caused by the interplay of seasonally varying tropical 5 upward mass flux, stratospheric transport barriers and recirculation. The annual mean spectrum, on the other hand, is found to be well described by an idealized stationary spectrum. Inter-annual variations in transport (e.g., QBO, ENSO) cause significant modulations of the age spectrum shape. In fact, one particular QBO phase may determine the spectrum’s mode during the following 2-3 years. Interpretation of the age spectrum in terms of transport contributions due to the residual circulation and mixing is generally not straightforward. Advection by the residual circulation turns out to represent the dominant pathway in 10 the deep tropics and in the winter hemisphere extratropics above 500K, controlling the modal age in these regions. In contrast, in the summer hemisphere, particularly in the lowermost stratosphere, mixing represents the most probable pathway controlling the modal age. Analysis of the full age spectrum compared to mean age is highly beneficial for separating the effects of different transport processes, and is strongly recommended as a diagnostic for model inter-comparisons.
Immunotherapy in viral warts with intradermal Bacillus Calmette–Guerin vaccine versus intradermal tuberculin purified protein derivative: A double-blind, randomized controlled trial comparing effectiveness and safety in a tertiary care center in Eastern India

Background: Current therapeutic modalities for viral warts are mostly ablative and are limited by high recurrence rates besides being unsuitable for numerous lesions. Immunotherapy has the potential to overcome these limitations. Aims: The aim of this study was to compare the effectiveness and safety of Bacillus Calmette–Guerin vaccine versus tuberculin purified protein derivative in the immunotherapy of warts. Methods: Patients received three doses of 0.1 ml of Bacillus Calmette–Guerin vaccine or tuberculin purified protein derivative intradermally over the deltoid region at 4-weekly intervals. They were followed-up for another month. Number of warts, complete cure rates and quality of life were assessed. Results: A total of 60 patients were included. Complete clearance was noted in 16 (48.5%) out of 33 patients in the Bacillus Calmette–Guerin group and in 5 (18.5%) out of 27 in the tuberculin purified protein derivative group (P = 0.121). The number of lesions reduced statistically significantly from baseline in both the groups (P < 0.001) from the first follow-up visit onward (P < 0.05). The reduction was statistically significantly more in the Bacillus Calmette–Guerin group than in the tuberculin purified protein derivative group from the second follow-up onward. Dermatologic life quality index improved statistically significantly with both treatments. Adverse events (pain during injection, abscess formation and scarring at injection site) were more frequent with Bacillus Calmette–Guerin. No recurrence was seen after lesions cleared. Limitations: Patients were not followed up for more than 4 weeks after treatment. We could not estimate the cytokine levels or the peripheral blood mononuclear cell proliferation in response to Bacillus Calmette–Guerin/tuberculin purified protein derivative injections. Conclusion: Both intradermal Bacillus Calmette–Guerin and tuberculin purified protein derivative hold promise in the treatment of viral warts. Bacillus Calmette–Guerin may be more effective, though it had more adverse events in our study.
Adequacy of the Ultra-Short-Term HRV to Assess Adaptive Processes in Youth Female Basketball Players

Abstract Heart rate variability has been widely used to monitor athletes’ cardiac autonomic control changes induced by training and competition, and recently shorter recording times have been sought to improve its practicality. The aim of this study was to test the agreement between the (ultra-short-term) natural log of the root-mean-square difference of successive normal RR intervals (lnRMSSD - measured in only 1 min post-1 min stabilization) and the criterion lnRMSSD (measured in the last 5 min out of 10 min of recording) in young female basketball players. Furthermore, the correlation between training induced delta change in the ultra-short-term lnRMSSD and the criterion lnRMSSD was calculated. Seventeen players were assessed at rest pre- and post-eight weeks of training. Trivial effect sizes (-0.03 in the pre- and 0.10 in the post- treatment) were found in the comparison between the ultra-short-term lnRMSSD (3.29 ± 0.45 and 3.49 ± 0.35 ms, in the pre- and post-, respectively) and the criterion lnRMSSD (3.30 ± 0.40 and 3.45 ± 0.41 ms, in the pre- and post-, respectively) (intraclass correlation coefficient = 0.95 and 0.93). In both cases, the response to training was significant, with Pearson’s correlation of 0.82 between the delta changes of the ultra-short-term lnRMSSD and the criterion lnRMSSD. In conclusion, the lnRMSSD can be calculated within only 2 min of data acquisition (the 1st min discarded) in young female basketball players, with the ultra-short-term measure presenting similar sensitivity to training effects as the standard criterion measure.
Interactive effects of perceived racism and coping responses predict a school-based assessment of blood pressure in black youth

Background: Research indicates that perceived racism and coping responses are associated with basal blood pressure (BP) levels and BP reactivity in Black adults. No study could be found, however, that has explored the independent and interactive effects of perceived racism and coping responses in a cohort who probably has the greatest risk of developing primary hypertension—Black youth.Purpose: This study examined the relationship of perceived racism and coping responses to a continuous measure of BP and to a categorical measure of BP status (normal vs. high-normal or high). Methods: The convenience sample consisted of 217 Black youth (M age = 11.4 years, SD = 1.3). Participants reported on perceived racism and coping responses (Accepting It, Self-Blame, Taking Action, and Talking to Someone). BP was assessed with an automated monitor in school.Results: Approximately 32% of the sample had average BP levels that were high-normal or high. Hierarchical linear and logistic regression analyses were used to assess the predictive utility of perceived racism and the four coping responses to the continuous and categorical BP assessments. Although perceived racism and the coping response variables did not emerge as significant independent predictors in the linear or logistic regression analyses, perceived racism interacted with Accepting It (p = .009) in the linear regression analysis predicting systolic BP. Follow-up linear regression analyses indicated that perceived racism was not significantly associated with systolic BP among participants low in Accepting It but was inversely related to systolic BP among participants high in Accepting It. Perceived racism also interacted with Accepting It (p = .016) and Talking to Someone (p = .0009) in the logistic regression analysis predicting BP status. Follow-up logistic regression analyses revealed that (a) perceived racism was not significantly associated with BP status among participants low in Accepting It but was inversely related to BP status among participants high in Accepting It, and (b) perceived racism was inversely associated with BP status among participants low in Talking to Someone but was not significantly related to BP status among participants high in Talking to Someone.Conclusions: The contribution of environmental and psychosocial factors to hypertension risk should be considered when exploring correlates of continuous and categorical assessments of BP in Black youth.
Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration

Total resection of adamantinomatous craniopharyngioma (ACP) is complex and often leads to postoperative recurrence. This is due to the tendency of the tumor to invade the surrounding brain tissue and the generation of a local inflammatory state between the tumor cells and parenchyma. While there is evidence to suggest that interleukin-6 (IL-6) induces craniopharyngioma (CP)-associated inflammation, particularly in ACP, the role of IL-6 in the progression of ACP remains unclear. The results of the present study demonstrated that CP inflammation was associated with pathological classification, extent of surgery, degree of calcification and postoperative hypothalamic status scale. Cytokine antibody arrays were conducted to measure the expression of IL-6 and other inflammatory factors in tumor tissues in response to various levels of inflammatory exposure. IL-6, IL-6 receptor (IL-6R) and glycoprotein 130 expression was detected by immunohistochemistry. In addition, an ELISA was performed to quantify the levels of soluble IL-6R (sIL-6R) in the cystic fluid and supernatants of ACP cells and tumor-associated fibroblasts. These measurements demonstrated that ACP cells produce IL-6 and its associated proteins. In addition, the results revealed that while the viability of ACP cells was not affected, the migration of ACP cells was promoted by IL-6 treatment in a concentration-dependent manner. Conversely, treatment with an IL-6-blocking monoclonal antibody significantly decreased the migration of ACP cells. In addition, IL-6 treatment increased the expression of vimentin and decreased the expression of E-cadherin in a dose-dependent manner. The findings of the present study demonstrate that IL-6 may promote migration in vitro via the classic- and trans-signaling pathways by inducing epithelial-mesenchymal transition in ACP cell cultures.
Mapping Convergent and Divergent Cortical Thinning Patterns in Patients With Deficit and Nondeficit Schizophrenia

Deficit schizophrenia (DS) is a homogeneous subtype of schizophrenia characterized by primary and enduring negative symptoms. However, the underlying neuroanatomical substrate of DS remains poorly understood. Here, we collected high-resolution structural magnetic resonance images of 115 participants, including 33 DS patients, 41 nondeficit schizophrenia (NDS) patients, and 41 healthy controls (HCs), and calculated the cortical thickness and surface area for statistical comparisons among the 3 groups. Relative to the control group, both the DS and NDS groups exhibited convergent cortical thinning in the bilateral inferior frontal gyri and the left superior temporal gyrus. The cortical thinning in the right inferior frontal cortex in the patient group was significantly positively correlated with declines of cognitive flexibility and visuospatial memory. Importantly, compared to the NDS group, the DS group exhibited a more widespread cortical thinning pattern, with the most significant differences in the left temporo-parietal junction area. For the surface area measurement, no significant group differences were observed. Collectively, these results highlight the convergent and divergent cortical thinning patterns between patients with DS and NDS, which provide critical insights into the neuroanatomical substrate of DS and improve our understanding of the biological mechanism that contributes to the negative symptoms and cognitive impairments in DS.
Effect of elevated CO 2 on the dynamics of particle-attached and free-living bacterioplankton communities in an Arctic fjord

The increase in atmospheric carbon dioxide (CO2) results in acidification of the oceans, expected to lead to the fastest drop in ocean pH in the last 300 million years, if anthropogenic emissions are continued at present rate. Due to higher solubility of gases in cold waters and increased exposure to the atmosphere by decreasing ice cover, the Arctic Ocean will be among the areas most strongly affected by ocean acidification. Yet, the response of the plankton community of high latitudes to ocean acidification has not been studied so far. This work is part of the Arctic campaign of the European Project on Ocean Acidification (EPOCA) in 2010, employing 9 in situ mesocosms of about 45 000 l each to simulate ocean acidification in Kongsfjorden, Svalbard (78°56.2' N 11°53.6' E). In the present study, we investigated effects of elevated CO2 on the composition and richness of particle attached (PA; >3 μm) and free living (FL; 0.2 μm) bacterial communities by Automated Ribosomal Intergenic Spacer Analysis (ARISA) in 6 of the mesocosms and the surrounding fjord, ranging from 185 to 1050 initial μatm pCO2. ARISA was able to resolve about 20–30 bacterial band-classes per sample and allowed for a detailed investigation of the explicit richness. Both, the PA and the FL bacterioplankton community exhibited a strong temporal development, which was driven mainly by temperature and phytoplankton development. In response to the breakdown of a picophytoplankton bloom (phase 3 of the experiment), number of ARISA-band classes in the PA-community were reduced at low and medium CO2 (∼180–600 μatm) by about 25%, while it was more or less stable at high CO2 (∼ 650–800 μatm). We hypothesise that enhanced viral lysis and enhanced availability of organic substrates at high CO2 resulted in a more diverse PA-bacterial community in the post-bloom phase. Despite lower cell numbers and extracellular enzyme activities in the post-bloom phase, bacterial protein production was enhanced in high CO2-treatments, suggesting a positive effect of community richness on this function and on carbon cycling by bacteria.
Initial severity of depression and efficacy of cognitive-behavioural therapy: individual-participant data meta-analysis of pill-placebo-controlled trials.

BackgroundThe influence of baseline severity has been examined for antidepressant medications but has not been studied properly for cognitive-behavioural therapy (CBT) in comparison with pill placebo.AimsTo synthesise evidence regarding the influence of initial severity on efficacy of CBT from all randomised controlled trials (RCTs) in which CBT, in face-to-face individual or group format, was compared with pill-placebo control in adults with major depression.MethodA systematic review and an individual-participant data meta-analysis using mixed models that included trial effects as random effects. We used multiple imputation to handle missing data.ResultsWe identified five RCTs, and we were given access to individual-level data (n = 509) for all five. The analyses revealed that the difference in changes in Hamilton Rating Scale for Depression between CBT and pill placebo was not influenced by baseline severity (interaction P = 0.43). Removing the non-significant interaction term from the model, the difference between CBT and pill placebo was a standardised mean difference of -0.22 (95% CI -0.42 to -0.02, P = 0.03, I2 = 0%). ConclusionsPatients suffering from major depression can expect as much benefit from CBT across the wide range of baseline severity. This finding can help inform individualised treatment decisions by patients and their clinicians.