Miracle-dz/UniFAR-FTUs huggingface dataset:
Attachment and family systems : conceptual, empirical, and therapeutic relatedness

THEORETICAL OVERVIEW 1. Implications of Attachment Research for the Field of Family Therapy, Robert Marvin FAMILY PERSPECTIVE 2. Family Level Emotional Climate and its Impact on the Flexibility of Relationship Representations, Jean Talbot and James McHale LIFE CYCLE TRANSITIONS: CHILD/ADOLESCENT PERSPECTIVE 3. Attachment Theory Applied to Adolescents, Stacy Cretzmeyer 4. Adolescence and Attachment: From Theory to Treatment Implications, Susan Mackey LIFE CYCLE TRANSITIONS: ADULT PERSEPCTIVE 5. Therapy with Clients' Attachment-Related Love and Work Struggles, Carole Pistole 6. The Systemic Nature of Couple Relationships: An Attachment Perspective, Judy Feeney 7. A Systemic Approach to Restructuring Adult Attachment: The EFT Model of Couples Therapy, Susan M. Johnson and Marlene Best SPECIFIC CLINICAL ISSUES 8. Linking Systems and Attachment Theory: A Conceptual Framework for Marital Violence, Claire Haslam and Phyllis Erdman 9. An Approach to Treatment of Attachment Issues in the Adult and Child Subsystems Through the Use of Thematic Play Therapy in Conjunction with Couples Therapy, Michael R. Carns, Robin English, Leslie Huling, Ann Carns 10. Integrative Systemic Approaches to Attachment-Related Trauma, Sylvia Marotta 11. Attachment Theory and Family Systems Theory as Frameworks for Understanding the Intergenerational Transmission of Family Violence, Pamela Alexander and Stephanie Warner
The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals.

BACKGROUND It has been suggested that a low dietary intake of antioxidant vitamins and minerals increases the incidence rate of cardiovascular disease and cancer. To date, however, the published results of randomized, placebo-controlled trials of supplements containing antioxidant nutrients have not provided clear evidence of a beneficial effect. We tested the efficacy of nutritional doses of supplementation with a combination of antioxidant vitamins and minerals in reducing the incidence of cancer and ischemic cardiovascular disease in the general population. METHODS The Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) study is a randomized, double-blind, placebo-controlled primary prevention trial. A total of 13 017 French adults (7876 women aged 35-60 years and 5141 men aged 45-60 years) were included. All participants took a single daily capsule of a combination of 120 mg of ascorbic acid, 30 mg of vitamin E, 6 mg of beta carotene, 100 mug of selenium, and 20 mg of zinc, or a placebo. Median follow-up time was 7.5 years. RESULTS No major differences were detected between the groups in total cancer incidence (267 [4.1%] for the study group vs 295 [4.5%] for the placebo group), ischemic cardiovascular disease incidence (134 [2.1%] vs 137[2.1%]), or all-cause mortality (76 [1.2%] vs 98 [1.5%]). However, a significant interaction between sex and group effects on cancer incidence was found (P = .004). Sex-stratified analysis showed a protective effect of antioxidants in men (relative risk, 0.69 [95% confidence interval [CI], 0.53-0.91]) but not in women (relative risk, 1.04 [95% CI, 0.85-1.29]). A similar trend was observed for all-cause mortality (relative risk, 0.63 [95% CI, 0.42-0.93] in men vs 1.03 [95% CI, 0.64-1.63] in women; P = .11 for interaction). CONCLUSIONS After 7.5 years, low-dose antioxidant supplementation lowered total cancer incidence and all-cause mortality in men but not in women. Supplementation may be effective in men only because of their lower baseline status of certain antioxidants, especially of beta carotene.
Slow breathing reduces sympathoexcitation in COPD

Neurohumoral activation has been shown to be present in hypoxic patients with chronic obstructive pulmonary disease (COPD). The aims of the present study were to investigate whether there is sympathetic activation in COPD patients in the absence of hypoxia and whether slow breathing has an impact on sympathoexcitation and baroreflex sensitivity. Efferent muscle sympathetic nerve activity, blood pressure, cardiac frequency and respiratory movements were continuously measured in 15 COPD patients and 15 healthy control subjects. Baroreflex sensitivity was analysed by autoregressive spectral analysis and the alpha-angle method. At baseline, sympathetic nerve activity was significantly elevated in COPD patients and baroreflex sensitivity was decreased (5.0±0.6 versus 8.9±0.8 ms·mmHg−1). Breathing at a rate of 6 breaths·min−1 caused sympathetic activity to drop significantly in COPD patients (from 61.3±4.6 to 53.0±4.3 bursts per 100 heartbeats) but not in control subjects (39.2±3.2 versus 37.5±3.3 bursts per 100 heartbeats). In both groups, slow breathing significantly enhanced baroreflex sensitivity. In conclusion, sympathovagal imbalance is present in normoxic chronic obstructive pulmonary disease patients. The possibility of modifying these changes by slow breathing may help to better understand and influence this systemic disease.
Self-Regulated Learning and Mathematics Achievement in a Fourth Grade Classroom

This research examines the relationship between self-regulated learning and mathematics achievement. The sample included 10 students enrolled in fourth grade at a small, private elementary school in the Midwest. During the third quarter of the school year, students were taught methods of learning mathematics through self-regulation. The grades were recorded before the implementation at the conclusion of the second quarter and again at the conclusion of the third quarter once self-regulation was implemented. A t-test was used to compare the mathematics scores. There was no significant difference between the second and third quarter mathematics grades. This is an important result as it differed from the findings in research. SELF-REGULATED LEARNING 1 Effective learners maintain many of the same traits. Recent literature has identified these traits as interest, curiosity, taking initiative, high levels of activation, autonomous work, persistence in the face of difficulties, and maintaining self-motivation toward the task at hand (Kuyper, van der Werf, & Lubbers, 2000). Furthermore, Zimmerman (1989) and Perry and VandeKamp (2000) have identified the described criterion which challenges students to take an active role in their personal learning environment and in ownership of their learning, as selfregulated learning. Self-regulated learning (SRL) is defined as a multi-dimensional process involving personal (cognitive and emotional), contextual, and behavioral components (Zimmerman, 1989). Self-regulated learning is viewed as proactive processes that students use to acquire academic skills, such as setting goals, selecting and deploying strategies, and selfmonitoring one’s effectiveness. This is in contrast to a more common reactive event that happens to students due to impersonal forces (Zimmerman, 2008). Teachers who use methods that incorporate self-regulated learning have found that the students are more responsible for the learning in the classroom setting (Middleton & Patrick, 2002). Self-regulated learning instruction can occur in many subject areas. However, according to Metallodou and Vlachou (2007) mathematics is still perceived as a threatening area; one that requires the application of cognitive strategies. The teaching of self-regulatory skills must be instilled in the students to encourage the application of productive study skills and to build ones’ self-efficacy in the area of math. If students in mathematics are going to become self-regulated learners, they need to be presented opportunities that allow them to reveal their thinking and to observe the thinking of others. While conclusive evidence has not been presented to demonstrate that self-regulated learners have overall higher achievement than non-self-regulated learners, Stoeger and Ziegler SELF-REGULATED LEARNING 2 (2008) show a growth rate in homework scores and quizzes in self-regulated learners that exceeded the average. The purpose of this study is to discover the relationship between a selfregulated learning environment and achievement levels in mathematics.
Separated Women's Risk for Violence

Abstract It is well known that women are at an increased risk for violence during separation. Existing research does not provide an understanding of why separated women are more at risk. The following study helps to fill this gap through an empirical examination of indicators derived from potential explanations for the relationship between separation and violence. Using Statistics Canada's 1999 General Social Survey (GSS), the study employs both descriptive and multivariate statistical analyses to examine the following variables: continuation of previous violence; immigrant status; youth; power; jealousy; and Aboriginal status. These risk factors accounted for over half of the variance in separation violence. This was largely due to the impact of age and Aboriginal status. The findings also showed that women without a previous history of violence were not protected from experiencing separation violence. The article concludes with a discussion of the findings.
Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

Huntington disease (HD) is a progressive neurodegenerative monogenic disorder caused by expansion of a polyglutamine stretch in the huntingtin (Htt) protein. Mutant huntingtin triggers neural dysfunction and death, mainly in the corpus striatum and cerebral cortex, resulting in pathognomonic motor symptoms, as well as cognitive and psychiatric decline. Currently, there is no effective treatment for HD. We report that intraventricular infusion of ganglioside GM1 induces phosphorylation of mutant huntingtin at specific serine amino acid residues that attenuate huntingtin toxicity, and restores normal motor function in already symptomatic HD mice. Thus, our studies have identified a potential therapy for HD that targets a posttranslational modification of mutant huntingtin with critical effects on disease pathogenesis.
Complex Care: Ventilation Management When Brain Injury and Acute Lung Injury Coexist

ABSTRACT The purpose of this article is to explore the management of coexisting brain insult and acute lung injury to help guide clinicians in balancing what may appear to be competing goals. First, contemporary management of mechanically ventilated patients with either brain or lung injury diagnoses is reviewed, followed by a review of intracranial pressure and acute lung injury/acute respiratory distress syndrome. The article ends with a discussion of a literature review regarding possible treatment balance when the two conditions coexist.
Cerebellar Brain-Derived Neurotrophic Factor–TrkB Defect Associated with Impairment of Eyeblink Conditioning in StargazerMutant Mice

In the spontaneous ataxic mutant mouse stargazer, there is a selective reduction of brain-derived neurotrophic factor (BDNF) mRNA expression in the cerebellum. BDNF protein levels in the cerebellum are reduced by 70%. Despite normal levels of full-length and truncated TrkB receptor, constitutive and neurotrophin-4/5-induced tyrosine phosphorylation was significantly reduced in several signal transduction molecules, including phospholipase-Cγ1, erk1, and erk2. Morphological examination revealed an increased number of external granule cells at postnatal day 15 and the presence of abnormal neurons resembling immature granule cells in the adult. These abnormalities are associated with a severe impairment in the acquisition of classical eyeblink conditioning, indicating cerebellar malfunction. Our data suggest that normal BDNF expression and TrkB signal transduction in the cerebellum are necessary for learning and plasticity in this model.
Corporate psychopaths : organisational destroyers

Introduction - Corporate Psychopaths as Organisational Destroyers The Origins of Corporate Psychopaths Corporate Psychopaths, Bullying, Conflict and Unfair Supervision in the Workplace The Influence of Corporate Psychopaths on Corporate Social Responsibility and Organisational Commitment to Employees Corporate Psychopaths and Organisational Constraints Corporate Psychopaths and Workload Corporate Psychopaths and Job Satisfaction The Organisational Seniority of Corporate Psychopaths Corporate Psychopaths and Organisational Type Corporate Psychopaths and Withdrawal from Work Critical Incidents in the Behaviour of Corporate Psychopaths Encouragement of Corporate Psychopaths by Organisations 206 Corporate Psychopaths compared to other Dark Leadership Personalities: Antisocial Personalities, Dissocial Personalities, Psychotics, Sociopaths, Narcissists and Machiavellians The Corporate Psychopaths Theory of the Global Financial Crisis Ethical Issues Involving Corporate Psychopaths
Impact of prior invasive aspergillosis on outcome in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplant

Invasive aspergillosis (IA) is a major cause of morbidity in patients with hematological malignancies, and a major impediment to the success of allogeneic stem cell transplant (allo-SCT). The aim of this single-center retrospective study was to determine the impact of pre-transplant IA on the outcome of allo-SCT after reduced-intensity conditioning (RIC). Twenty-eight cases of proven or probable IA were diagnosed prior to RIC allo-SCT at the Paoli-Calmettes Institute Cancer Center between January 2000 and January 2008. These cases were identified among 360 patients undergoing allo-SCT. IA was defined according to EORTC criteria. Patients had predominantly (82%) acute myeloid leukemia, were diagnosed with IA at a median of 8 months (range, 1–16) pre-transplant, and received antifungal therapy for a median of 5 months (range, 1–13). IA therapy included: voriconazole (71%); single-agent itraconazole (14%); and a combination of agents (14%). Secondary prophylaxis against aspergillosis was maintained during conditioning and post-transplant in 89% of patients. After transplant, only three patients (11%) had reactivation of their IA and one patient developed disseminated fusariosis. The latter four patients experienced severe acute GVHD treated with high-dose corticosteroids. None of these patients died of IA. Eighteen patients (64%) are still alive, with a median follow-up of 23.5 months (range, 12.6–48.5). Overall survival at 2 years was 59% (95% CI, 43–83%). These data suggest that patients with adequately controlled IA can tolerate RIC allo-SCT without significant post-transplant complications.
Determine reasons for repeat drinking and driving

Amy Berning served as the Contracting Officer's Technical Representative (COTR) for this study. Highway Traffic Safety Administration, in the interest of information exchange. The opinions, findings and conclusions expressed in this publication of those of the author(s) and not necessarily those of the Department of Transportation or the National Highway Traffic Safety Administration. The United States Government assumes no liability for it contents or use thereof. If trade or manufacturers' names or products are mentioned, it is because they are considered essential to the object of the publication and should not be construed as an endorsement. The United States Government does not endorse products or manufacturers. This report was not originally formatted for electronic release. As such, there may be problems with spacing, page numbering and/or graphs and tables. If you would like a printed copy of this report, limited copies are available from NHTSA's Office of Program Development and Evaluation. Please send your request to Ms. ACKNOWLEDGMENTS The authors are grateful to the many individuals who worked on this project. We would especially like to thank the following individuals for promoting the implementation of the study in their respective locations: We are most grateful to all of the counselors and probation officers who conducted the interviews. The interviewers in all three project sites should be commended for persevering despite sometimes discouraging days filled with refusals and missed appointments by potential participants. The efforts of all of the interviewers and supporting staff are greatly appreciated. We thank all who assisted in the planning, implementation, interview process and analyses of data in connection with this study. This document reports the results of a study on why some individuals repeatedly drive while under the influence or intoxicated, even after being convicted of DWI. Through qualified interviewers (trained counselors and probation officers in the substance abuse field), we were able to ask repeat offenders directly about their experiences with the legal and adjudication process, as well as learn about their personal backgrounds. All of the information used for analyses during the course of this project was obtained from audio taped recordings of " one-on-one " interviews with individuals convicted of driving under the influence, or while intoxicated or impaired. Most interviews were approximately one hour in duration. One hundred and eighty-two (182) interviews were conducted at three project sites (Phoenix, Arizona; Pittsburgh, Pennsylvania; and the 18th Judicial District in Colorado) between February and …
Language and Space

2 Introduction Foreword My own interest in space and language was sparked off by the regularities I observed in the case systems of Finnish and Hungarian. Though the facts are often obvious and have been pointed out many times in the literature, I was surprised to find that most literature is concerned only with the morphological aspects of space, and that there seemed to be very little on semantics. The more I looked into the matter the more I discovered how fascinating the area is; I also learned that there is a lot of material on space and language, but it tends to be somewhat lesser known. There is a noticeable trend to take the linguistics of space more serious also from a theoretical point of view. The present book does not attempt to provide a typological survey, nor is it uniquely theoretical in character. I have tried to create a synthesis between linguistically oriented investigation (involving syntax, morphology and historical development) and formal ones (which include the mathematical structure of space and other spatial concepts). Inevitably, some parts of the book will be hard going for a linguist and they might therefore disapprove of my overly formal stance. Yet, I hope that such readers will benefit nevertheless from this work even if they skip such sections. On the other hand, when formal accounts of meanings can be given I think they should be given. This is what science is about: trying ones best at rendering our ideas precise. The following book grew out of lectures that I gave at the University of Cal-ifornia, Los Angeles. I am indebted to my students, Smith for their input. Also, I benefitted from discussions with Peter Svenonius as well as various people that have been subjected to talks on various aspects of that matter. Introduction 3 Introduction Considering the importance space plays in everyday life, the amount of linguistic research that has gone into space and spatial expressions is rather small. Within semantics, the literature on tense and aspect by far exceeds that on space, not to mention binding theory and other areas. From the perspective of a syntactician, spatial expressions do not seem to offer fundamental insights into language the way binding theory does. Yet, this seems to me to be a prejudice. Investigating the language of space has several advantages: • The domain of space and location is fairly well-understood due …
RECENT DEVELOPMENTS IN QUANTITATIVE MODELS OF SOVEREIGN DEFAULT

The current crisis and discussions, in the euro area in particular, show that sovereign debt crises/defaults are no longer restricted to developing economies. After crises in many Latin American countries, the literature on quantitative dynamic macro-models of sovereign default has been advancing. Current debate should take notice of the findings from this literature - an extensive overview of which has been provided in this paper. This paper also discusses the difficulties involved in, but also possibilities of, integrating this type of model in standard business cycle models (RBC and DSGE models). This is likely to be particularly helpful when using models to analyse upcoming issues in the euro area, such as a suitable (sovereign) insolvency law or the assumption of joint liability.
Potentially Prognostic miRNAs in HPV-Associated Oropharyngeal Carcinoma

Purpose: Deregulation of miRNAs is associated with almost all human malignancies. Human papillomavirus (HPV)-associated oropharyngeal carcinoma (OPC) has a significantly more favorable outcome compared with HPV-negative OPCs; however, the underlying mechanisms are not well understood. Hence, the objectives of this study were to determine whether miRNA expression differed as a function of HPV status and to assess whether such miRNAs provide prognostic value beyond HPV status. Methods: Global miRNA profilings were conducted on 88 formalin-fixed and paraffin-embedded (FFPE) OPC biopsies (p16-positive: 56; p16-negative: 32), wherein the expression levels of 365 miRNAs plus 3 endogenous controls were simultaneously measured using quantitative real-time (qRT)-PCR. Seven FFPE specimens of histologically normal tonsils were used as controls. Results: Overall, 224 miRNAs were expressed in more than 80% of the investigated samples, with 128 (57%) being significantly differentially expressed between tumor versus normal tissues (P < 0.05). Upregulated miR-20b, miR-9, and miR-9* were significantly associated with HPV/p16-status. Three miRNA sets were significantly associated with overall survival (miR-107, miR-151, miR-492; P = 0.0002), disease-free survival (miR-20b, miR-107, miR-151, miR-182, miR-361; P = 0.0001), and distant metastasis (miR-151, miR-152, miR-324-5p, miR-361, miR492; P = 0.0087), which retained significance even after adjusting for p16 status. The associated biologic functions of these miRNAs include immune surveillance, treatment resistance, invasion, and metastasis. Conclusion: We have identified several miRNAs, which associate with HPV status in OPC; furthermore, three candidate prognostic sets of miRNAs seem to correlate with clinical outcome, independent of p16 status. Furthermore, evaluations will offer biologic insights into the mechanisms underlying the differences between HPV-positive versus HPV-negative OPC. Clin Cancer Res; 19(8); 2154–62. ©2013 AACR.