Miracle-dz/UniFAR-FTUs huggingface dataset:
A Case of Therapy-related Acute Lymphoblastic Leukemia with t(11;19)(q23;p13.3) and MLL/MLLT1 Gene Rearrangement

Therapy-related ALL (t-ALL) is a rare secondary leukemia that develops after chemotherapy and/or radiotherapy for primary malignancies. Chromosomal 11q23 abnormalities are the most common karyotypic alterations in t-ALL. The t(11;19)(q23;p13) aberration is extremely rare and has not been confirmed at the molecular genetic level. Here, we report a case of t-ALL with t(11;19)(q23;p13.3) and MLL-MLLT1 (alias ENL) gene rearrangement confirmed by cytogenetic analysis, multiplex reverse transcription-PCR (multiplex RT-PCR), and DNA sequencing in a patient who had undergone treatment for breast cancer. A 40-yr-old woman developed acute leukemia 15 months after undergoing 6 cycles of adjuvant chemotherapy (doxorubicin 60 mg/m2 and cyclophosphamide 600 mg/m2), radiation therapy (dose, 5,900 cGy), and anticancer endocrine therapy with tamoxifen. The complete blood cell counts and bone marrow examination showed increased blasts and the blasts showed B lineage immunophenotype (positive for CD19, CD34, and cytoplasmic CD79a). Cytogenetic analysis revealed the karyotype 47,XX,+X,t(11;19)(q23;p13.3)[4]/46,XX[16]. FISH analyses, multiplex RT-PCR, and DNA sequencing confirmed the MLL-MLLT1 gene rearrangement. The patient underwent induction chemotherapy with fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD) and achieved complete remission. Subsequently, she underwent consolidation chemotherapy, but died of brain ischemia in the pons and the region of the middle cerebral artery. To our knowledge, this is the first case report of t-ALL with t(11;19)(q23;p13.3) and the MLL-MLLT1 gene rearrangement.
Detecting short tandem repeats from genome data: opening the software black box

Short tandem repeats, specifically microsatellites, are widely used genetic markers, associated with human genetic diseases, and play an important role in various regulatory mechanisms and evolution. Despite their importance, much is yet unknown about their mutational dynamics. The increasing availability of genome data has led to several in silico studies of microsatellite evolution which have produced a vast range of algorithms and software for tandem repeat detection. Documentation of these tools is often sparse, or provided in a format that is impenetrable to most biologists without informatics background. This article introduces the major concepts behind repeat detecting software essential for informed tool selection. We reflect on issues such as parameter settings and program bias, as well as redundancy filtering and efficiency using examples from the currently available range of programs, to provide an integrated comparison and practical guide to microsatellite detecting programs.
Decoding speech in the presence of other sound sources

Conventional speech recognition is notoriously vulnerable to additive noise, and even the best compensation methods are defeated if the noise is nonstationary. To address this problem, we propose a new integration of bottom-up techniques to identify ‘coherent fragments’ of spectro-temporal energy (based on local features), with the top-down hypothesis search of conventional speech recognition, extended to search also across possible assignments of each fragment as speech or interference. Initial tests demonstrate the feasibility of this approach, and achieve a reduction in word error rate of more than 25% relative at 5 dB SNR over stationary noise missing data recognition.
Segmentation and Punctuation: Developmental Data from Young Writers in a Bilingual Program

Nine first grade, nine second grade, and eight third grade children of migrant farm workers provided the data for a descriptive study of writing development in one bilingual program. Of the many analyses that were performed on the data, the one presented here concerns early segmentation and punctuation. Unconventional seg- mentation was found to have two predominant bases (syntactic and phonological/morphological) and two infrequent bases ("anti"-syntactic and "anti"-phonological/morphological). With the exception of data from a few children, almost all unconventional segmentation honored syntactic or phonological boundaries. Conventionality was achieved first in "major" syntactic units (e.g., propositions, noun phrases) and later in "minor" units (e.g., prepositional phrases). Early invented punctuation patterns focused on the line, the word, or the page and often involved separation. Later patterns were related to "textness. " Both segmentation and punctuation varied with the language of the text, the type of writing, and writing materials. In the United States today, many educators encounter oral and written language development issues in not one, but two or more languages. If there are any universals in language or literacy acquisition (Ferreiro & Teberosky, 1982; Harste, 1980), then data from multi- or other-than-Eng- lish language settings should be useful to educators whose major concern is the English language arts. The data presented here are from a larger study on the development of writing in a bilingual program. In general, the entire study shows that these particular children's knowledge of and performance in writing was greatly influenced by contextual features (teacher beliefs, materials pro- vided, topic, genre, etc.) At the same time, children's writing seemed to develop through internal and individual processes of hypothesis creating/ testing and schema development/tapping. There was no evidence that growth was proceeding from differentially reinforced approximations or
Recovering Bodies: Illness, Disability, and Life Writing

This text focuses on the writing by and about people with illness or disability - and in particular HIV/AIDS, breast cancer, deafness and paralysis - challenging the stigmas attached to their conditions by telling their lives in their own ways and on their own terms. Discussing memoirs, diaries, collaborative narratives, photo documentaries, essays and other forms of life writing, G. Thomas Couser shows that these books are not primarily records of medical conditions; they are a means for individuals to recover their bodies (or those of loved ones) from marginalization and impersonal medical discourse. Responding to the recent growth of illness and disability narratives in the United States - such works as Juliet Wittman's "Breast Cancer Journal", John Hockenberry's "Moving Violations", Paul Monette's "Borrowed Time: An AIDS Memoir" and Lou Ann Walker's "A Loss for Words: The Story of Deafness in a Family" - Couser addresses questions of both poetics and politics. He examines why and under what circumstances individuals choose to write about illness or disability, what role plot plays in such narratives; how and whether closure is achieved; who assumes the prerogative of narration; which conditions are most often represented; and which literary conventions lend themselves to representing particular conditions. By tracing the development of new subgenres of personal narrative in our time, this book explores how explicit consideration of illness and disability has enriched the repertoire of life writing. In addition, Couser's discussion of medical discourse joins the current debate about whether the biomedical model is entirely conducive to human care for ill and disabled people. With its sympathetic critique of the testimony of those most affected by these conditions, "Recovering Bodies" contributes to an understanding of the relations among bodily dysfunction, cultural conventions and identity in contemporary America.
Supporting Exploration Awareness in Information Visualization

When users want to continue an analysis performed in the past, done by themselves or by a collaborator, they need an overview of what has been done and found so far. Such an overview helps them to gain a shared knowledge about each otherspsila analysis strategy and continue the analysis. We aim to support users in this process, and thereby support their exploration awareness. We present an information visualization framework with three linked processes: overview, search and retrieve for this purpose. First, we present a userpsilas information interest model that captures key aspects of the exploration process. Exploration overview, and keyword and similarity based search mechanisms are designed based on these key aspects. A metadata view is used to visualize the search results and help users to retrieve specific visualizations from past analysis. Finally, we present three case studies and discuss the support offered by the framework for developing exploration awareness.
PLL-Less Nonlinear Current-Limiting Controller for Single-Phase Grid-Tied Inverters: Design, Stability Analysis, and Operation Under Grid Faults

A nonlinear controller for single-phase grid-tied inverters, that can operate under both a normal and a faulty grid with guaranteed closed-loop stability, is proposed. The proposed controller acts independently from the system parameters, does not require a phase-locked loop, and can achieve the desired real power regulation and unity power factor operation. Based on nonlinear input-to-state stability theory, it is analytically proven that the inverter current always remains below a given value, even during transients, independently from grid variations or faults (short circuit or voltage sag). The desired performance and stability of the closed-loop system are rigorously proven since the controller has a structure that does not require any switches, additional limiters, or monitoring devices for its implementation. Therefore, nonlinear stability of a grid-tied inverter with a given current-limiting property is proven for both normal and faulty grid conditions. The effectiveness of the proposed approach is experimentally verified under different operating conditions of the grid.
Azithromycin for the treatment of pertussis

A prospective, open label, noncomparative trial was conducted to assess the efficacy of a 5-day course of azithromycin in bacteriologic eradication of pertussis. Patients received azithromycin 10 mg/ kg/day on Day 1 and then 5 mg/kg/day for the next 4 days. Nasopharyngeal specimens for culture and PCR testing were used to identify Bordetella pertussis at enrollment and at Day 2 to 3 and 14 to 21 after start of treatment. Of 121 subjects enrolled with clinical pertussis, 29 were culture-positive and 5 additional subjects were PCR-positive at diagnosis. Eradication of B. pertussis from the nasopharynx occurred in 33 (97%) of 34 culture/PCR-positive patients by the second to third day of azithromycin treatment; the 1 positive case was by PCR only; 100% were culture/PCR-negative at the Day 14 to 21 follow-up visit.
Long-term sustained remission in a cohort study of patients with rheumatoid arthritis: choice of remission criteria

Objectives Remission is a widely accepted goal for treatment of rheumatoid arthritis (RA) but has to be sustained to arrest joint damage and disability. However, appropriate criteria for the assessment of sustained remission in long-term studies are not established. Therefore, we have compared the disease activity score calculated on 28 joints (DAS28) remission criterion, the Simplified Disease Activity Index less than 3.3 remission criterion (SDAI Cr) and the new Boolean-based set of criteria (Boolean Cr), and assessed the association of these criteria with radiographic and functional outcome. Design Prospective, long-term observational study of patients with early RA. Setting Secondary level of care; six participating centres from southern Sweden; both urban and rural populations. Participants 698 patients were consecutively included in the study and 527 remained at the 8-year follow-up visit. Almost all patients were Caucasians, of which 64% were women. To be included, a patient, 18 years or older, had to fulfil the 1987 American College of Rheumatology criteria for RA and have a disease duration of no more than 1 year. Results Sustained remission was most common by the DAS28 Cr (14%), while 3% met the Boolean Cr and 5% the SDAI Cr, the latter figures increasing to 9% and 8%, respectively, when the patient’s global assessment was excluded. Radiographic joint damage was common but least pronounced in patients in sustained remission by all criteria. Sustained remission was associated with rapid and lasting improvement in function assessed by the Health Assessment questionnaire, irrespective of criteria. Conclusions The DAS28 Cr acquired more patients in sustained remission compared with the other criteria. In spite of that, radiographic damage and disability were not worse than that seen by other criteria and the patients’ perspective was preserved. The DAS28 Cr may therefore still be used in long-term observational studies until more accurate criteria are available.
Eye-gaze experiments for conversation monitoring

Eye-tracking technology has recently been matured so that its use in studies dealing with unobtrusive and natural user experiments has become easier to conduct. Simultaneously, human computer interactions have become more conversational in style, and more challenging in that they require various human conversational strategies, such as giving feedback and managing turn-taking. In this paper, we focus on eye-gaze in order to investigate turn taking signals and conversation monitoring in naturally occurring dialogues. We seek to build models that deal with the important aspects of which interlocutor the speaker is talking to, and what kind of turn taking signals the partners elicit, and we report the first results of our eye-tracking experiments.
Treating Victims of Torture and Violence: Theoretical Cross-Cultural, and Clinical Implications

Torture is among the most disturbing and psychologically devastating of human behaviors. It dehumanizes its victims, leaving them with serious and lasting psychological wounds. Like other psychological trauma, torture frequently leaves in its wake denial and silence among both perpetrators and their victims. This communicative void creates a public and mental block that can make treatment of torture survivors very difficult. Treating Victims of Torture and Violence is the definitive manual for therapists treating victims of torture, prisoners of war, and casualties of forced migration. Divided into five sections dealing with basic concepts of torture--violence and aggression, the torture syndrome, psychotherapeutic treatment, the cultural psychology of torture syndrome, and cultural psychological treatment-- Treating Victims of Torture and Violence employs both classic psychoanalytic and cognitive- behavioral methods. Realizing that torture victims are frequently from different cultures than those of their therapists, Peter Elsass provides in-depth aid to therapists dealing with a multicultural clientele.
Exposing Parameters of a Trained Dynamic Model for Interactive Music Creation

As machine learning (ML) systems emerge in end-user applications, learning algorithms and classifiers will need to be robust to an increasingly unpredictable operating environment. In many cases, the parameters governing a learning system cannot be optimized for every user scenario, nor can users typically manipulate parameters defined in the space and terminology of ML. Conventional approaches to user-oriented ML systems have typically hidden this complexity from users by automating parameter adjustment. We propose a new paradigm, in which model and algorithm parameters are exposed directly to end-users with intuitive labels, suitable for applications where parameters cannot be automatically optimized or where there is additional motivation - such as creative flexibility - to expose, rather than fix or automatically adapt, learning parameters. In our CHI 2008 paper, we introduced and evaluated MySong, a system that uses a Hidden Markov Model to generate chords to accompany a vocal melody. The present paper formally describes the learning underlying MySong and discusses the mechanisms by which MySong's learning parameters are exposed to users, as a case study in making ML systems user-configurable. We discuss the generalizability of this approach, and propose that intuitively exposing ML parameters is a key challenge for the ML and human-computer-interaction communities.
Planned and reactive agility performance in semiprofessional and amateur basketball players.

CONTEXT Research indicates that planned and reactive agility are different athletic skills. These skills have not been adequately assessed in male basketball players. PURPOSE To define whether 10-m-sprint performance and planned and reactive agility measured by the Y-shaped agility test can discriminate between semiprofessional and amateur basketball players. METHODS Ten semiprofessional and 10 amateur basketball players completed 10-m sprints and planned- and reactive-agility tests. The Y-shaped agility test involved subjects sprinting 5 m through a trigger timing gate, followed by a 45° cut and 5-m sprint to the left or right through a target gate. In the planned condition, subjects knew the cut direction. For reactive trials, subjects visually scanned to find the illuminated gate. A 1-way analysis of variance (P < .05) determined between-groups differences. Data were pooled (N = 20) for a correlation analysis (P < .05). RESULTS The reactive tests differentiated between the groups; semiprofessional players were 6% faster for the reactive left (P = .036) and right (P = .029) cuts. The strongest correlations were between the 10-m sprints and planned-agility tests (r = .590-.860). The reactive left cut did not correlate with the planned tests. The reactive right cut moderately correlated with the 10-m sprint and planned right cut (r = .487-.485). CONCLUSIONS The results reemphasized that planned and reactive agility are separate physical qualities. Reactive agility discriminated between the semiprofessional and amateur basketball players; planned agility did not. To distinguish between male basketball players of different ability levels, agility tests should include a perceptual and decision-making component.
Licamichauxiioic-A and -B Acids - Two Ent-Kaurene Diterpenoids from Licania Michauxii

Bioassay-guided fractionation allowed the isolation of two new cytotoxic ent-kaurene diterpenoids, licamichauxiioic-A and -B acids (1 and 2) from the root extract of Licania michauxii Prance (Chrysobalanaceae). They were characterized as ent-15-oxo-9(11),16-kauradien-19-oic acid (1) and ent-15-oxo-13(14),16-kauradien-19-oic acid (2) by various spectroscopic methods, in particular, 1D and 2D NMR spectra, and chemical evidence.
Behavioral couples therapy for male substance-abusing patients: a cost outcomes analysis.

The cost outcomes for married or cohabiting substance-abusing male patients (N = 80) who were randomly assigned to receive either behavioral couples therapy (BCT) or individual-based treatment (IBT) were compared. Social costs incurred by patients in several areas (e.g., cost of substance abuse treatment, support from public assistance) during the year before and the year after treatment were estimated. BCT was more cost-beneficial than IBT; although the monetary outlays for delivering IBT and BCT were not different, the average reduction in aggregate social costs from baseline to follow-up was greater for patients who received BCT (i.e., $6,628) than for patients who received IBT (i.e., $1,904). BCT was also more cost-effective than IBT; for each $100 spent on the treatment, BCT produced greater improvements than IBT on several indicators of treatment outcome (e.g., fewer days of substance use, fewer legal problems).
SAVI objects: sharing and virtuality incorporated

Direct sharing and storing of memory objects allows high-performance and low-overhead collaboration between parallel processes or application workflows with loosely coupled programs. However, sharing of objects is hindered by the inability to use subtype polymorphism which is common in object-oriented programming languages. That is because implementations of subtype polymorphism in modern compilers rely on using virtual tables stored at process-specific locations, which makes objects unusable in processes other than the creating process. In this paper, we present SAVI Objects, objects with Sharing and Virtuality Incorporated. SAVI Objects support subtype polymorphism but can still be shared across processes and stored in persistent data structures. We propose two different techniques to implement SAVI Objects and evaluate the tradeoffs between them. The first technique is virtual table duplication which adheres to the virtual-table-based implementation of subtype polymorphism, but duplicates virtual tables for shared objects to fixed memory addresses associated with each shared memory region. The second technique is hashing-based dynamic dispatch which re-implements subtype polymorphism using hashing-based look-ups to a global virtual table. Our results show that SAVI Objects enable direct sharing and storing of memory objects that use subtype polymorphism by adding modest overhead costs to object construction and dynamic dispatch time. SAVI Objects thus enable faster inter-process communication, improving the overall performance of production applications that share polymorphic objects.
Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro

A desmopressin‐induced ACTH increase has been recently suggested to be specific for pituitary‐dependent Cushing's disease. We present the case of a 47‐year‐old woman with Cushing's syndrome due to ectopic ACTH production by a bronchial carcinoid. While CRH failed to induce an ACTH or cortisol response, intravenous administration of desmopressin led to a 47% increase in serum ACTH and a 42% increase in serum cortisol concentration. After surgical removal of the tumour, the desmopressin response became negative. In vitro, ACTH production by tumour cells obtained at surgery was also stimulated by desmopressin but not by CRH. Additional receptor mRNA expression studies using RT‐PCR revealed expression of both V2 and V3 vasopressin receptor subtypes in the carcinoid tumour at a level comparable to that recently described in pituitary corticotroph adenomas. This case illustrates that ACTH stimulation by desmopressin is not specific for pituitary‐dependent Cushing's syndrome as vasopressin receptor subtypes known to interact with desmopressin may also be found in ectopic tumours producing ACTH.