Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional Organization of Vestibular Commissural Connections in Frog

Central vestibular neurons receive substantial inputs from the contralateral labyrinth through inhibitory and excitatory brainstem commissural pathways. The functional organization of these pathways was studied by a multi-methodological approach in isolated frog whole brains. Retrogradely labeled vestibular commissural neurons were primarily located in the superior vestibular nucleus in rhombomeres 2/3 and the medial and descending vestibular nucleus in rhombomeres 5–7. Restricted projections to contralateral vestibular areas, without collaterals to other classical vestibular targets, indicate that vestibular commissural neurons form a feedforward push–pull circuitry. Electrical stimulation of the contralateral coplanar semicircular canal nerve evoked in canal-related second-order vestibular neurons (2°VN) commissural IPSPs (∼70%) and EPSPs (∼30%) with mainly (∼70%) disynaptic onset latencies. The dynamics of commissural responses to electrical pulse trains suggests mediation predominantly by tonic vestibular neurons that activate in all tonic 2°VN large-amplitude IPSPs with a reversal potential of −74 mV. In contrast, phasic 2°VN exhibited either nonreversible, small-amplitude IPSPs (∼40%) of likely dendritic origin or large-amplitude commissural EPSPs (∼60%). IPSPs with disynaptic onset latencies were exclusively GABAergic (mainly GABAA receptor-mediated) but not glycinergic, compatible with the presence of GABA-immunopositive (∼20%) and the absence of glycine-immunopositive vestibular commissural neurons. In contrast, IPSPs with longer, oligosynaptic onset latencies were GABAergic and glycinergic, indicating that both pharmacological types of local inhibitory neurons were activated by excitatory commissural fibers. Conservation of major morpho-physiological and pharmacological features of the vestibular commissural pathway suggests that this phylogenetically old circuitry plays an essential role for the processing of bilateral angular head acceleration signals in vertebrates.
An axiomatic approach to characterizing and relaxing strategyproofness of one-sided matching mechanisms

We study one-sided matching mechanisms where agents have vNM utility functions and report ordinal preferences. We first show that in this domain strategyproof mechanisms are characterized by three intuitive axioms: swap monotonicity, upper invariance, and lower invariance. Our second result is that dropping lower invariance leads to an interesting new relaxation of strategyproofness, which we call partial strategyproofness. In particular, we show that mechanisms are swap monotonic and upper invariant if and only if they are strategyproof on a restricted domain where agents have sufficiently different valuations for different objects. Furthermore, we show that this domain restriction is maximal and use it to define a single-parameter measure for the degree of strategyproofness of a manipulable mechanism. We also provide an algorithm that computes this measure. Our new partial strategyproofness concept finds applications in the incentive analysis of non-strategyproof mechanisms, such as the Probabilistic Serial mechanism, different variants of the Boston mechanism, and the construction of new hybrid mechanisms.
Risk factors for initial lung metastasis from breast invasive ductal carcinoma in stages I-III of operable patients.

OBJECTIVE The aim of this study was to evaluate high-risk factors for initial lung metastases from breast invasive ductal carcinomas in operable patients with Stages I-III invasive ductal carcinoma. METHODS Data of all patients who underwent radical mastectomy were reviewed retrospectively, and they were confirmed with invasive ductal breast cancer between January 2003 and December 2007. Routine clinical examination data of patients included in the study at primary diagnosis, adjuvant modes and first metastasis sites were recorded. Possible risk factors were easily identified from patients. Twenty-eight potential risk factors were investigated. Finally, 78 patients with complete data in the potential factors were found eligible, and univariate and multivariate analyses were conducted. RESULTS Univariate analyses showed that the status of estrogen receptor (ER) and progesterone receptor (PR) and the status of the epidermal growth factor receptor-2 (Her2) were high-risk factors for invasive ductal breast cancer metastasis to the lung as the first organ. P values were, respectively, 0.045, 0.049 and 0.026. Multivariate analyses showed that the pN3 stage needs to be combined with vascular invasion to predict initial lung metastasis. The status of ER and PR was also viewed in combination with p53 negative to predict lung metastasis. Further analyses demonstrated that a subtype of four negative in breast cancer was significantly associated with initial lung metastasis. CONCLUSIONS Patients with pN3 stage and vascular invasion were more likely to develop lung metastasis. A new subtype with Her2 negative, both ER-negative and PR negative combination with p53 negative, had a great tendency to develop initial lung metastasis in breast invasive ductal cancer patients.
Beliefs, Attitudes, and Practices of Breastfeeding Mothers From a Periurban Community in South Africa

The aim of this study was to document the breastfeeding practices, beliefs, and attitudes of periurban South African lactating mothers with infants younger than 6 months. None of the mothers (n = 115, mean age 26 ± 6.3 years) reported exclusively breastfeeding their infants, with complementary breastfeeding being the most practiced (78%) feeding mode. Complementary foods were fed to 32% of infants by their first month of life. Perceived inadequate production of breast milk was the most common (90%) reason cited for adding foods and liquids to breastfeeds. Mothers valued use of traditional herbal preparations (muthi), with more then half (56%) of the infants having received their first dose of muthi before 1 month of age. Our study provides important data on breastfeeding practices of women living within resource-poor settings. Development of successful infant-feeding interventions aimed at promoting overall infant health can benefit from knowledge of these breastfeeding patterns.
Developing a clinical decision model: MR spectroscopy to differentiate between recurrent tumor and radiation change in patients with new contrast-enhancing lesions.

OBJECTIVE Differentiation between recurrent neoplasm and postradiation change in patients previously treated for primary brain tumors is often difficult based on imaging features alone. The purpose of this study was to develop a method using alterations in the ratios of standard brain metabolites-choline (Cho), creatine (Cr), and N-acetylaspartate (NAA)-to predict the probability of tumor recurrence in patients previously treated for brain tumors with new contrast-enhancing lesions. MATERIALS AND METHODS Thirty-three patients who had undergone treatment for primary brain tumors in whom routine MRI showed new contrast-enhancing lesions were retrospectively studied. The final diagnosis was assigned using histopathology (n = 13) or imaging follow-up (n = 20; range, 2-27 months). Ratios of three metabolites (Cho, Cr, and NAA) were calculated, and the results were correlated with the final diagnosis using a Wilcoxon's rank sum analysis. A logistic regression model was then used to create a prediction model based on the most statistically significant ratio. RESULTS Elevations of the metabolic ratios Cho/Cr (p < 0.001) and Cho/NAA (p < 0.001) and a decrease in the ratio NAA/Cr (p = 0.018) were found in patients with recurrent tumor (n = 20) versus those with postradiation change (n = 13). A prediction model using the Cho/NAA ratio yielded a sensitivity of 85%, a specificity of 69.2%, and an area under the receiver operating characteristic curve of 0.92. CONCLUSION An elevated Cho/NAA ratio correlated with evidence of tumor recurrence and allowed creation of a prediction rule to aid in lesion classification. The results suggest that MR spectroscopy is a useful tool in assigning patients with nonspecific enhancing lesions to either invasive biopsy or conservative management.
A Framework for Assessing the Costs and Benefits to Developing Countries of TRIPs-Plus Rules in Trade Agreements

This paper looks at a variety of channels through which TRIPS-plus (TPS) provisions of trade agreements can impose costs or provide benefits to developing countries, by imposing stronger patent protections for pharmaceuticals. It describes these costs and benefits and how in principle it might be possible to quantify them. This summary briefly outlines the discussion of each of the main costs and benefits.
Unbounded Innovation with Digitalization : A Case of Digital Camera *

A four-layer model of generic architectural innovation is proposed that explain loose couplings between different layers of digital innovations. We develop the model based on key design features of digital technology – homogenization of digital data, universal programmable digital computer, and the selfreferential nature of digital technology. We show how these features and the new layer architecture affects innovation outcomes (convergence, and digital materiality) and processes (generativity, heterogeneity, locus of innovation, and pace). We illustrate the emergence and evolution of these features by investigating the history of digital camera and its transformation from a single purpose analog product into a complex product laden with multiple meanings consisting of web of loosely coupled capabilities associated with digital imaging. The unbounded, chaotic and dynamic nature of digital innovation was discussed for its implications for future research and practice. * This research was supported by a grant from the U.S. National Science Foundation (#VOSS-0943157). The paper will be presented at the Academy of Management Annual Meeting 2010.
Two-Stream Convolutional Networks for Dynamic Saliency Prediction

In recent years, visual saliency estimation in images has attracted much attention in the computer vision community. However, predicting saliency in videos has received rela- tively little attention. Inspired by the recent success of deep convolutional neural networks based static saliency mod- els, in this work, we study two different two-stream convo- lutional networks for dynamic saliency prediction. To im- prove the generalization capability of our models, we also introduce a novel, empirically grounded data augmenta- tion technique for this task. We test our models on DIEM dataset and report superior results against the existing mod- els. Moreover, we perform transfer learning experiments on SALICON, a recently proposed static saliency dataset, by finetuning our models on the optical flows estimated from static images. Our experiments show that taking motion into account in this way can be helpful for static saliency estimation.
Performance and metabolic responses to a high caffeine dose during prolonged exercise.

The present study examined whether a high caffeine dose improved running and cycling performance and altered substrate metabolism in well-trained runners. Seven trained competitive runners [maximal O2 uptake (VO2max) 72.6 +/- 1.5 ml.kg-1.min-1] completed four randomized and double-blind exercise trials at approximately 85% VO2max; two trials running to exhaustion and two trials cycling to exhaustion. Subjects ingested either placebo (PL, 9 mg/kg dextrose) or caffeine (CAF, 9 mg/kg) 1 h before exercise. Endurance times were increased (P less than 0.05) after CAF ingestion during running (PL 49.2 +/- 7.2 min, CAF 71.0 +/- 11.0 min) and cycling (PL 39.2 +/- 6.5 min, CAF 59.3 +/- 9.9 min). Plasma epinephrine concentration [EPI] was increased (P less than 0.05) with CAF before running (0.22 +/- 0.02 vs. 0.44 +/- 0.08 nM) and cycling (0.31 +/- 0.06 vs. 0.45 +/- 0.06 nM). CAF ingestion also increased [EPI] (P less than 0.05) during exercise; PL and CAF values at 15 min were 1.23 +/- 0.13 and 2.51 +/- 0.33 nM for running and 1.24 +/- 0.24 and 2.53 +/- 0.32 nM for cycling. Similar results were obtained at exhaustion. Plasma norepinephrine was unaffected by CAF at rest and during exercise. CAF ingestion also had no effect on respiratory exchange ratio or plasma free fatty acid data at rest or during exercise. Plasma glycerol was elevated (P less than 0.05) by CAF before exercise and at 15 min and exhaustion during running but only at exhaustion during cycling. Urinary [CAF] increased to 8.7 +/- 1.2 and 10.0 +/- 0.8 micrograms/ml after the running and cycling trials. (ABSTRACT TRUNCATED AT 250 WORDS)
Recovery of Motor Functions following Hemiparetic Stroke: A Clinical and Magnetic Resonance-Morphometric Study

Predictors for the degree of clinical recovery after stroke are still poorly defined. In this study we tried to assess the predictive value of clinical data and of lesion size for motor recovery after ischemic stroke. In 52 hemiparetic patients we monitored the course of clinical recovery by a dedicated score of sensorimotor hand function after their first stroke. The course of the lesion size was measured in proton density magnetic resonance images. Three groups of patients were identified. Patients with moderate initial motor deficit recovered almost completely within 9 days (17/17, group 1). From the patients with severe initial motor deficit, about equal numbers recovered (16/35, group 2) or remained severely impaired during the entire observation period of more than 6 months (19/35, group 3). There was no correlation between changes of lesion size and motor deficit. Logistic regression of probability of good clinical outcome on initial lesion size, initial motor score and subcortical versus cortical location of lesion showed that only the initial motor score was predictive (p = 0.006). A relative improvement of the initial motor score of about 20% in the first 4 weeks after stroke appeared to be a relevant cut point for good outcome. The data indicate that patients with mild initial motor deficits recover well, whereas severely affected patients may differ in outcome. Since lesion size was not correlated with outcome the amount of spared residual function appeared as major determinant for the capacity for motor recovery.
Ability-Performance Relationships in Education and Employment Settings

The nature of the relationship between ability and performance is of critical importance for admission decisions in the context of higher education and for personnel selection. Although previous research has supported the more-is-better hypothesis by documenting linearity of ability-performance relationships, such research has not been sensitive enough to detect deviations at the top ends of the score distributions. An alternative position receiving considerable attention is the good-enough hypothesis, which suggests that although higher levels of ability may result in better performance up to a threshold, above this threshold greater ability does not translate to better performance. In this study, the nature of the relationship between cognitive ability and performance was examined throughout the score range in four large-scale data sets. Monotonicity was maintained in all instances. Contrary to the good-enough hypothesis, the ability-performance relationship was commonly stronger at the top end of the score distribution than at the bottom end.
A randomised comparison of cognitive behavioural therapy (CBT) and eye movement desensitisation and reprocessing (EMDR) in disaster-exposed children

Background : Building on previous research with disaster-exposed children and adolescents, a randomised clinical trial was performed in the treatment of trauma-related symptoms. In the current study two active treatments were compared among children in a broad age range and from a wide diversity of ethnic populations. Objective : The primary aim was to compare the effectiveness and efficiency of Cognitive Behavioural Therapy (CBT) and Eye Movement Desensitisation and Reprocessing (EMDR). Design : Children (n=52, aged 4–18) were randomly allocated to either CBT (n=26) or EMDR (n=26) in a disaster mental health after-care setting after an explosion of a fireworks factory. All children received up to four individual treatment sessions over a 4–8 week period along with up to four sessions of parent guidance. Blind assessment took place pre- and post-treatment and at 3 months follow-up on a variety of parent-rated and self-report measures of post-traumatic stress disorder symptomatology, depression, anxiety, and behaviour problems. Analyses of variance (general linear model repeated measures) were conducted on the intention-to-treat sample and the completers. Results : Both treatment approaches produced significant reductions on all measures and results were maintained at follow-up. Treatment gains of EMDR were reached in fewer sessions. Conclusion : Standardised CBT and EMDR interventions can significantly improve functioning of disaster-exposed children. For the abstract in other languages, please see Supplementary files under Reading Tools online
Reward-Based Decision Signals in Parietal Cortex Are Partially Embodied

Recordings in the lateral intraparietal area (LIP) reveal that parietal cortex encodes variables related to spatial decision-making, the selection of desirable targets in space. It has been unclear whether parietal cortex is involved in spatial decision-making in general, or whether specific parietal compartments subserve decisions made using specific actions. To test this, we engaged monkeys (Macaca mulatta) in a reward-based decision task in which they selected a target based on its desirability. The animals' choice behavior in this task followed the molar matching law, and in each trial was governed by the desirability of the choice targets. Critically, animals were instructed to make the choice using one of two actions: eye movements (saccades) and arm movements (reaches). We recorded the discharge activity of neurons in area LIP and the parietal reach region (PRR) of the parietal cortex. In line with previous studies, we found that both LIP and PRR encode a reward-based decision variable, the target desirability. Crucially, the target desirability was encoded in LIP at least twice as strongly when choices were made using saccades compared with reaches. In contrast, PRR encoded target desirability only for reaches and not for saccades. These data suggest that decisions can evolve in dedicated parietal circuits in the context of specific actions. This finding supports the hypothesis of an intentional representation of developing decisions in parietal cortex. Furthermore, the close link between the cognitive (decision-related) and bodily (action-related) processes presents a neural contribution to the theories of embodied cognition.
Microwave System for Head Imaging

A wideband microwave system for head imaging is presented. The system includes an array of 16 corrugated tapered slot antennas that are installed on an adjustable platform. A switching device is used to enable the antennas to sequentially send a wideband 1-4 GHz microwave signal and capture the backscattered signals. Those signals are recorded using suitably designed virtual instrument software architecture. To test the capability of the system to detect brain injuries, a low-cost mixture of materials that emulate the frequency-dispersive electrical properties of the major brain tissues across the frequency band 1-4 GHz are used to construct a realistic-shape head phantom. A target that emulates a realistic hemorrhage stroke is fabricated and inserted in two different locations inside the fabricated head phantom. A preprocessing algorithm that utilizes the symmetry of the two halves of human head is used to extract the target response from the background reflections. A post-processing confocal algorithm is used to get an image of the phantom and to accurately detect the presence and location of the stroke.
Bounds and Extremal Configurations for the Torsional Rigidity of Coated Fiber Reinforced Shafts

In this paper we derive bounds on the torsional rigidity for coated fiber reinforced shafts. The bounds are used to assess the optimality or suboptimality of fiber reinforcement configurations. This investigation focuses on coated fiber reinforcements with circular cross section. It is shown how the effective antiplane shear modulus and torsional rigidity of each coated fiber are used to determine whether the configuration provides reinforcement above or below that of a homogeneous shaft containing no coated fibers. Simply connected shaft cross sections of arbitrary shape reinforced with any configuration of coated fibers are considered. Precise conditions on the effective antiplane shear modulus and torsional rigidity of each coated fiber are given under which the circular shaft reinforced with a single centered circular coated fiber is either optimal or suboptimal.
A study of the impact of synoptic weather conditions and water vapor on aerosol–cloud relationships over major urban clusters of China

Abstract. The relationships between aerosol optical depth (AOD), cloud cover (CC), and cloud top pressure (CTP) over three major urban clusters in China are studied under different sea level pressure (SLP) and water vapor (WV) regimes using a decade (2003–2013) of MODIS satellite-retrieved data. Over all urban clusters, for all SLP regimes, CC is found to increase with AOD, thus pointing out that the CC dependence on AOD cannot be explained by synoptic covariation, as approximated by SLP, alone. WV is found to have a stronger impact on CC than AOD. This impact is more pronounced at high aerosol load than at low aerosol load. Hence, studies of AOD–CC relationships, based on satellite data, will greatly overestimate the AOD impact on CC in regions where AOD and WV have similar seasonal variations, while they will probably underestimate the AOD impact in regions where AOD and WV have opposite seasonal variations. Further, this impact shows that the hydrological cycle interferes with the aerosol climatic impact and we need to improve our understanding of this interference. Our results also suggest that studies attributing CTP long-term changes to changes in aerosol load might have a WV bias.
Increased Glycolytic ATP Synthesis Is Associated with Tafenoquine Resistance in Leishmania major

ABSTRACT Tafenoquine (TFQ), an 8-aminoquinoline used to treat and prevent Plasmodium infections, could represent an alternative therapy for leishmaniasis. Indeed, TFQ has shown significant leishmanicidal activity both in vitro and in vivo, where it targets Leishmania mitochondria and activates a final apoptosis-like process. In order not to jeopardize the life span of this potential antileishmania drug, it is important to determine the likelihood that Leishmania will develop resistance to TFQ and the mechanisms of resistance induced. To address this issue, a TFQ-resistant Leishmania major promastigote line (R4) was selected. This resistance, which is unstable in a drug-free medium (revertant line), was maintained in intramacrophage amastigote forms, and R4 promastigotes were found to be cross-resistant to other 8-aminoquinolines. A decreased TFQ uptake, which is probably associated with an alkalinization of the intracellular pH rather than drug efflux, was observed for both the R4 and revertant lines. TFQ induces a decrease in ATP synthesis in all Leishmania lines, although total ATP levels were maintained at higher values in R4 parasites. In contrast, ATP synthesis by glycolysis was significantly increased in R4 parasites, whereas mitochondrial ATP synthesis was similar to that in wild-type parasites. We therefore conclude that increased glycolytic ATP synthesis is the main mechanism underlying TFQ resistance in Leishmania.