Miracle-dz/UniFAR-FTUs huggingface dataset:
A Reliability Enhancement Mechanism for High-Assurance MLC Flash-Based Storage Systems

Solid State Devices (SDDs) are replacing mechanical data storage devices such as Hard Disk Drives (HDDs). On the other hand the data reliability in these systems is being questioned due to the fast growth in flash technology such as Multi-Level Cell (MLC). Recently it has been revealed that the Bit Error Rate (BER) increases exponentially in MLC flash memories as they experience more flash writes. Additionally RAID in flash-based storage systems has an inherent problem, that all flash devices should not reachend of life at the same time. Diff-RAID [2] overcomes the said problem. However, Diff-RAID mechanism suffers from drastic age-variation especially during the first few replacements, a problem that has been identified and addressed in this research. A new reliability enhancement mechanism for high-assurance MLC flash-based storage systems has been proposed here, and is compared with published Diff-RAID results. Our mechanism has shown promising results. In terms of convergence, the proposed scheme is 7 times faster. Furthermore, no single device crosses 66% of the age (i.e. max. erasure cycles), unlike the Diff-RAID where in the first few replacements, few devices reach 70-80% of age, which is great improvement in terms of data reliability.
Residual lattice strains in plastically deformed poly-crystalline metal aggregates

The residual lattice strain observed by X-ray diffraction methods in plastically extended polycrystalline aggregates has been investigated. It is shown that, if several diffraction lines are examined, the residual lattice strains vary both in magnitude and in sign. It is known that one of the causes of internal stresses in a plastically deformed polycrystalline aggregate is the variation with orientation of the yield tensions of the crystals in the aggregate. Since only grains with certain orientations contribute to a given diffraction line, the lattice strain measured is not the mean strain in all the crystals, which should be zero, but the average of the strains in those crystals with particular orientations, which may be positive or negative. It is considered that this constitutes one of the reasons for the hitherto unexplained observations which have been made on residual lattice strains. Quantitative conclusions from this explanation are in satisfactory agreement with observations.
Channel code blocklength and rate optimization for progressive image transmission

We investigate the problem of selecting blocklength and code rate for progressive image transmission, motivated by turbo coding methods where the performance improves with blocklength. The problem is to balance the tradeoff among error protection, source coding rate, and delay. We propose a general performance measure for evaluating progressive transmission and use dynamic programming to determine the channel code parameters based on the progressive performance. Performance results are provided for the evaluation of the gains over less complex methods as a function of channel error rate.
Development of Novel Real-Time PCR Assays for Detection and Differentiation of Eleven Medically Important Aspergillus and Candida Species in Clinical Specimens

ABSTRACT In the present study, novel real-time PCR assays targeting the fungal ITS2 region were developed for the detection and differentiation of medically important Aspergillus species (Aspergillus fumigatus, Aspergillus flavus, Aspergillus nidulans, Aspergillus niger, and Aspergillus terreus) and Candida species (Candida albicans, Candida dubliniensis, Candida glabrata, Candida krusei, Candida parapsilosis, and Candida tropicalis) using a LightCycler instrument. The combination of a group-specific and a universal primer with five Aspergillus or six Candida species-specific biprobes in one reaction mixture facilitated rapid screening and species differentiation by the characteristic peak melting temperatures of the biprobes. Both assays can be performed either as single assays or simultaneously in the same LightCycler run. The analytical sensitivity using pure cultures and EDTA-anticoagulated blood, cerebrospinal fluid (CSF), and tissue samples spiked with A. fumigatus and C. albicans cell suspensions was shown to be at least 1 CFU per PCR, corresponding to 5 to 10 CFU/ml blood and 10 CFU/200 μl CSF or 0.02 g tissue. To assess the clinical applicability, 26 respiratory samples, 4 tissue samples from the maxillary sinus, and 1 blood sample were retrospectively tested and real-time PCR results were compared with results from culture, histology, or a galactomannan enzyme-linked immunosorbent assay (ELISA). Twenty samples (64.5%) were both culture positive and positive by real-time PCR. Six samples (19.4%) showed no growth of fungi but were positive by real-time PCR. However, all of the tissue samples were positive by both PCR and histology. The blood sample showed no growth of Aspergillus, but aspergillosis was confirmed by positive galactomannan ELISA, histology, and PCR results. The remaining samples (16.1%) were culture and PCR negative; also, no other signs indicating fungal infection were observed. Our data suggest that the Aspergillus and Candida assays may be appropriate for use in clinical laboratories as simple and rapid screening tests for the most frequently encountered Aspergillus and Candida species and might become an important tool in the early diagnosis of fungal infections in the future.
User acceptance factors of hospital information systems and related technologies: Systematic review

ABSTRACT This study reviews the literature on the most important acceptance factors associated with Hospital Information Systems (HIS) and related technologies based on user groups’ perspectives (medical staff, hospital management, administrative personnel, patient, medical student, and IT staff), which can assist researchers and hospital management to develop suitable acceptance models to improve the quality of HIS. We conducted searches in online databases with large repositories of academic studies, written in English and fully accessible by the authors. The articles being reviewed are related to health information technology (HIT), clinical information systems (CIS), HIS, electronic medical records (EMR), telemedicine or telehealth, picture archiving and communication systems (PACS), radio frequency identification (RFID), and computerized physician order entry (CPOE), where the use of most of those applications and technologies is highly integrated. A predefined string was used to extract 1,005 articles, and the results were reviewed and checked. The results of this study found 15 user acceptance factors related to HIS and related technologies that were frequently identified by a minimum of five previous studies. These factors were related to individual, technological, and organizational factors. In addition, HIS and related technologies’ user acceptance factors in each user group describe different results.
Notch Ligand Delta-Like 4-Pretreated Dendritic Cells Alleviate Allergic Airway Responses by Enhancing IL-10 Production

The Notch pathway plays a role in the processes of cell proliferation, differentiation, and apoptosis, which affect the development and function of various organs. Dendritic cells (DCs), as professional antigen-presenting cells (APCs), induce T cell activation and promote T cell differentiation by antigen stimulation. Research has shown that Notch ligand delta-like 4 (Dll4) in APCs is associated with stimulation of a Th1-type response. However, the regulatory roles of Dll4 in the activation and function of DCs have yet to be clearly elucidated. In this study, we demonstrated that activation of Dll4-pretreated bone marrow-derived DCs by performing ovalbumin (OVA) stimulation expressed a high level of interleukin (IL)-10 without diminishing IL-12 production. By contrast, the proinflammatory cytokines, IL-1β, IL-6, and tumor necrosis factor (TNF)-α, decreased in Dll4-pretreated DCs by performing either lipopolysaccharide (LPS) or OVA stimulation. Compared to fully mature DCs, lower levels of MHC class II CD40 and higher levels of CD80 and CD86 molecules were expressed in these semi-mature like DCs. Dll4 Notch signaling also enhanced Notch ligand mRNA expression of Dll1, Dll4, and Jagged1 in DCs. Dll4-modified DCs exhibited a reduced capacity to stimulate the proliferation of OVA-specific CD4+ T cells, but actively promoted large amounts of IL-10 production in these activated T cells. Furthermore, immunomodulatory effects of Dll4-modified DCs were examined in an established asthmatic animal model. After adoptive transfer of OVA-pulsed plus Dll4-pretreated DCs in OVA-immunized mice, OVA challenge induced lower OVA-specific immunoglobulin E (IgE) and higher IgG2a antibody production, lower eotaxin, keratinocyte-derived chemokine (KC), IL-5, and IL-13 release in bronchial alveolar lavage fluid, attenuated airway hyper-responsiveness, and promoted higher IL-10 and interferon (IFN)-γ production in the spleen. In summary, our findings elucidate the new role of Dll4 in the phenotype and function of DCs and provide a novel approach for manipulating T cell-driven deleterious immune diseases.
Deamplification of pfmdr1-Containing Amplicon on Chromosome 5 in Plasmodium falciparum Is Associated with Reduced Resistance to Artelinic Acid In Vitro

ABSTRACT Amplification of the Plasmodium falciparum multidrug resistance 1 gene (pfmdr1) has been implicated in multidrug resistance, including in vitro resistance to artelinic acid (AL). The stability and fitness of having multiple copies of pfmdr1 are important factors due to their potential effects on the resistance phenotype of parasites. These factors were investigated by using an AL-resistant line of P. falciparum (W2AL80) and clones originating from W2AL80. A rapid reduction in pfmdr1 copy number (CN) was observed in the uncloned W2AL80 line; 63% of this population reverted to a CN of <3 without exposure to the drug. Deamplification of the pfmdr1 amplicon was then determined in three clones, each initially containing three copies of pfmdr1. Interestingly, two outcomes were observed during 3 months without drug pressure. In one clone, parasites with fewer than 3 copies of pfmdr1 emerged rapidly. In two other clones, the reversion was significantly delayed. In all subclones, the reduction in pfmdr1 CN involved the deamplification of the entire amplicon (19 genes). Importantly, deamplification of the pfmdr1 amplicon resulted in partial reversal of resistance to AL and increased susceptibility to mefloquine. These results demonstrate that multiple copies of the pfmdr1-containing amplicon in AL-resistant parasites are unstable when drug pressure is withdrawn and have practical implications for the maintenance and spread of parasites resistant to artemisinin derivatives.
Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells

Cajal-Retzius (CR) cells play a key role in the formation of the cerebral cortex. These pioneer neurons are distributed throughout the cortical marginal zone in distinct graded distributions. Fate mapping and cell lineage tracing studies have recently shown that CR cells arise from restricted domains of the pallial ventricular zone, which are associated with signalling centres involved in the early regionalisation of the telencephalic vesicles. In this study, we identified a subpopulation of CR cells in the rostral telencephalon that expresses Er81, a downstream target of Fgf8 signalling. We investigated the role of the rostral telencephalic patterning centre, which secretes FGF molecules, in the specification of these cells. Using pharmacological inhibitors and genetic inactivation of Fgf8, we showed that production of Fgf8 by the rostral telencephalic signalling centre is required for the specification of the Er81+ CR cell population. Moreover, the analysis of Fgf8 gain-of-function in cultivated mouse embryos and of Emx2 and Gli3 mutant embryos revealed that ectopic Fgf8 signalling promotes the generation of CR cells with a rostral phenotype from the dorsal pallium. These data showed that Fgf8 signalling is both required and sufficient to induce rostral CR cells. Together, our results shed light on the mechanisms specifying rostral CR cells and further emphasise the crucial role of telencephalic signalling centres in the generation of distinct CR cell populations.
Role of Nuclear Factor Erythroid 2–Related Factor 2 in the Oxidative Stress–Dependent Hypertension Associated With the Depletion of DJ-1

Renal dopamine 2 receptor dysfunction is associated with oxidative stress and high blood pressure (BP). We have reported that DJ-1, an oxidative stress response protein, is positively regulated by dopamine 2 receptor in the kidney. The transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) regulates the expression of several antioxidant genes. We tested the hypothesis that Nrf2 is involved in the renal DJ-1–mediated inhibition of reactive oxygen species production. We have reported that silencing dopamine 2 receptor in mouse renal proximal tubule cells decreases the expression of DJ-1. We now report that silencing DJ-1 or dopamine 2 receptor in mouse proximal tubule cells and mouse kidneys decreases Nrf2 expression and activity and increases reactive oxygen species production; BP is also increased in mice in which renal DJ-1 or dopamine 2 receptor is silenced. DJ-1−/− mice have decreased renal Nrf2 expression and activity and increased nitro-tyrosine levels and BP. Silencing Nrf2 in mouse proximal tubule cells does not alter the expression of DJ-1 or dopamine 2 receptor, indicating that Nrf2 is downstream of dopamine 2 receptor and DJ-1. An Nrf2 inducer, bardoxolone, normalizes the systolic BP and renal malondialdehyde levels in DJ-1−/− mice without affecting them in their wild-type littermates. Because Nrf2 ubiquitination is increased in DJ-1−/− mice, we conclude that the protective effect of DJ-1 on renal oxidative stress is mediated, in part, by preventing Nrf2 degradation. Moreover, renal dopamine 2 receptor and DJ-1 are necessary for normal Nrf2 activity to keep a normal redox balance and BP.
Apical Dominance and Shoot Branching. Divergent Opinions or Divergent Mechanisms?1

Apical dominance is the term used to describe the control of the shoot tip over axillary bud outgrowth (e.g. [Cline, 1997][1]). It is best demonstrated via shoot tip removal (decapitation), which leads to apical dominance. Indeed, decapitation has been widely used to study bud outgrowth. In contrast
Active Galactic Nucleus and Starburst Classification from Spitzer Mid-Infrared Spectra for High-Redshift SWIRE Sources

Spectra have been obtained with the Infrared Spectrograph (IRS) on the Spitzer Space Telescope for 20 sources in the Lockman Hole field of the SWIRE survey. The sample is divided between sources with indicators of an obscured AGN, based primarily on X-ray detections of optically faint sources, and sources with indicators of a starburst, based on optical and near-infrared spectral energy distributions (SEDs), which show a luminosity peak from stellar photospheric emission. Ten of the 11 AGN sources have IRS spectra that show silicate absorption or are power laws; only one AGN source shows PAH emission features. All nine of the sources showing starburst SEDs in the near-infrared show PAH emission features in the IRS spectra. Redshifts are determined from the IRS spectra for all nine starbursts (1.0 < z < 1.9) and 8 of the 11 AGNs (0.6 < z < 2.5). Classification as AGN because of an X-ray detection, the classification as AGN or starburst derived from the photometric SED, and the IRS spectroscopic classification as AGN (silicate absorption) or starburst (PAH emission) are all consistent in 18 of 20 sources. The surface density for starbursts that are most luminous in the mid-infrared is less than that for the most luminous AGNs within the redshift interval 1.7 ≲ z ≲ 1.9. This result implies that mid-infrared source counts at high redshift are dominated by AGNs for fν(24 μm) ≳ 1.0 mJy.
Incidence and Course of Suicidal Ideation and Suicide Attempts in the General Population

Objective: Suicidal ideation and suicide attempts are important indicators of extreme emotional distress. However, little is known about predictors of onset and course of suicidality in the general population. Our study tried to fill this gap by analyzing data from a prospectively followed community sample. Method: Data were derived from the Netherlands Mental Health Survey and Incidence Study (NEMESIS), a 3-wave cohort study in a representative sample (n = 4848) of the Dutch adult general population. Results: The 3-year incidence of suicidal ideation and suicide attempts was 2.7% and 0.9%, respectively. Predictors of first-onset suicidal ideation and suicide attempts were sociodemographic variables (especially the negative change in situation variables), life events, personal vulnerability indicators, and emotional (mood and anxiety) disorders. Comparison of the corresponding odds ratios and confidence intervals revealed that predictors for first-onset suicidal ideation and suicide attempts did not differ significantly. One of the strongest predictors of incident suicide attempts was previous suicidal ideation. Regarding the course of suicidal ideation, it was found that 31.3% still endorsed these thoughts and 7.4% reported having made a suicide attempt 2 years later. Conclusions: Similar predictors were found for first-onset suicidal ideation and suicide attempts. This suggests that suicidal behaviours may be ordered on a continuum and have shared risk factors. While suicidal thoughts may be necessary for, they are not sufficient predictors of, suicidal acts. The course of suicidality in the general population can be characterized by a minority of people having suicidal experiences that develop over time with progressively increasing severity.
On light propagation in helicoidal bianisotropic mediums

We have shown liquid crystals to be members of the more general class of helicoidal bianisotropic mediums (HBMs) and have discussed physical realizations of HBMs as liquid crystals, cross-linked polymer networks and solid thin films. Solutions of the time-harmonic Maxwell postulates for axial propagation in a HBM have been derived in terms of the eigenvalues and eigenvectors of a 4 x 4 matrix. We have given a procedure to obtain the response of a HBM slab to a normally incident plane wave and exemplified our analytical results by application to four mediums.
Wearables in epilepsy and Parkinson's disease—A focus group study

Wearable sensors that measure movement and physiological variables are attractive for clinical evaluation of neurological diseases such as epilepsy and Parkinson's disease (PD). The aim of this study was to explore perceptions regarding the use of wearable technology in disease monitoring and management as reported by individuals with epilepsy and Parkinson's disease as well as health professionals working with these patient groups.
Synthesis of β-Tubulin, Actin, and Other Proteins in Axons of Sympathetic Neurons in Compartmented Cultures

The proteins needed for growth and maintenance of the axon are generally believed to be synthesized in the cell bodies and delivered to the axons by anterograde transport. However, recent reports suggest that some proteins can also be synthesized within axons. We used [35S]methionine metabolic labeling to investigate axonal protein synthesis in compartmented cultures of sympathetic neurons from newborn rats. Incubation of distal axons for 4 hr with [35S]methionine resulted in a highly specific pattern of labeled axonal proteins on SDS-PAGE, with 4 prominent bands in the 43–55 kDa range. The labeled proteins in axons were not synthesized in the cell bodies, because they were also produced by axons after the cell bodies had been removed. Two of the proteins were identified by immunoprecipitation as actin and β-tubulin. Axons synthesized <1% of the actin and tubulin synthesized in the cell bodies and transported into the axons, and 75–85% inhibition of axonal protein synthesis by cycloheximide and puromycin failed to inhibit axonal elongation. Nonetheless, the specific production by axons of the major proteins of the axonal cytoskeleton suggests that axonal protein synthesis arises from specific mechanisms and likely has biological significance. One hypothetical scenario involves neurons with long axons in vivo in which losses from turnover during axonal transport may limit the availability of cell body synthesized proteins to the distal axons. In this case, a significant fraction of axonal proteins might be supplied by axonal synthesis, which could, therefore, play important roles in axonal maintenance, regeneration, and sprouting.
Cytotoxicity Analysis of Three Bacillus thuringiensis Subsp. israelensis δ-Endotoxins towards Insect and Mammalian Cells

Three members of the δ-endotoxin group of toxins expressed by Bacillus thuringiensis subsp. israelensis, Cyt2Ba, Cry4Aa and Cry11A, were individually expressed in recombinant acrystalliferous B. thuringiensis strains for in vitro evaluation of their toxic activities against insect and mammalian cell lines. Both Cry4Aa and Cry11A toxins, activated with either trypsin or Spodoptera frugiperda gastric juice (GJ), resulted in different cleavage patterns for the activated toxins as seen by SDS-PAGE. The GJ-processed proteins were not cytotoxic to insect cell cultures. On the other hand, the combination of the trypsin-activated Cry4Aa and Cry11A toxins yielded the highest levels of cytotoxicity to all insect cells tested. The combination of activated Cyt2Ba and Cry11A also showed higher toxic activity than that of toxins activated individually. When activated Cry4Aa, Cry11A and Cyt2Ba were used simultaneously in the same assay a decrease in toxic activity was observed in all insect cells tested. No toxic effect was observed for the trypsin-activated Cry toxins in mammalian cells, but activated Cyt2Ba was toxic to human breast cancer cells (MCF-7) when tested at 20 µg/mL.
Open-domain textual question answering techniques

Textual question answering is a technique of extracting a sentence or text snippet from a document or document collection that responds directly to a query. Open-domain textual question answering presupposes that questions are natural and unrestricted with respect to topic. The question answering (Q/A) techniques, as embodied in today's systems, can be roughly divided into two types: (1) techniques for Information Seeking (IS), which localize the answer in vast document collections; and (2) techniques for Reading Comprehension (RC) that answer a series of questions related to a given document. Although these two types of techniques and systems are different, it is desirable to combine them for enabling more advanced forms of Q/A. This paper discusses an approach that successfully enhanced an existing IS system with RC capabilities. This enhancement is important because advanced Q/A, as exemplified by the ARDA AQUAINT program, is moving towards Q/A systems that incorporate semantic and pragmatic knowledge enabling dialogue-based Q/A. Because today's RC systems involve a short series of questions in context, they represent a rudimentary form of interactive Q/A which constitutes a possible foundation for more advanced forms of dialogue-based Q/A.
Strategic Delay in a Real Optimna Model of R&D Competition

This paper considers irreversible investment in competing research projects with uncertain returns under a winner-takes-all patent system. Uncertainty takes two distinct forms: the technological success of the project is probabilistic, while the economic value of the patent to be won evolves stochastically over time. According to the theory of real options uncertainty generates an option value of delay, but with two competing firms the fear of preemption would appear to undermine this approach. In non-cooperative equilibrium two patterns of investment emerge depending on parameter values.