Miracle-dz/UniFAR-FTUs huggingface dataset:
The Work of Adult and Pediatric Intensive Care Unit Nurses

Background:Researchers have used various methods to describe and quantify the work of nurses. Many of these studies were focused on nursing in general care settings; therefore, less is known about the unique work nurses perform in intensive care units (ICUs). Objectives:The aim of this study was to observe adult and pediatric ICU nurses in order to quantify and compare the duration and frequency of nursing tasks across four ICUs as well as within two discrete workflows: nurse handoffs at shift change and patient interdisciplinary rounds. Methods:A behavioral task analysis of adult and pediatric nurses was used to allow unobtrusive, real-time observation. A total of 147 hours of observation were conducted in an adult medical–surgical, a cardiac, a pediatric, and a neonatal ICU at one rural, tertiary care community teaching hospital. Results:Over 75% of ICU nurses’ time was spent on patient care activities. Approximately 50% of this time was spent on direct patient care, over 20% on care coordination, 28% on nonpatient care, and approximately 2% on indirect patient care activities. Variations were observed between units; for example, nurses in the two adult units spent more time using monitors and devices. A high rate and variety of tasks were also observed: Nurses performed about 125 activities per hour, averaging a switch between tasks every 29 seconds. Discussion:This study provides useful information about how nurses spend their time in various ICUs. The methodology can be used in future research to examine changes in work related to, for example, implementation of health information technology.
What Does Dual Pathway Wenckebach Mean?

The AV nodal Wenckebach cycles still puzzle clinicians and physiologists a century after their eponymous description.1 Their fingerprint is a progressive increase in PR interval leading to a blocked beat and repeatedly occurring when the atrial cycle length becomes shorter than the functional refractory period of the AV node.2 The phenomenon can be spontaneous and induced by atrial pacing in depressed and normally conducting AV node, respectively. We now learn from Zhang and Mazgalev3 that classical rate-dependent AV nodal Wenckebach cycles sequentially involve conduction in the fast and slow pathway, a landmark observation supporting a new functional significance for these cycles.
A Scalable High-Bandwidth Architecture for Lossless Compression on FPGAs

Data compression techniques have been the subject of intense study over the past several decades due to exponential increases in the quantity of data stored and transmitted by computer systems. Compression algorithms are traditionally forced to make tradeoffs between throughput and compression quality (the ratio of original file size to compressed file size). FPGAs represent a compelling substrate for streaming applications such as data compression thanks to their capacity for deep pipelines and custom caching solutions. Unfortunately, data hazards in compression algorithms such as LZ77 inhibit the creation of deep pipelines without sacrificing some amount of compression quality. In this work we detail a scalable fully pipelined FPGA accelerator that performs LZ77 compression and static Huffman encoding at rates up to 5.6 GB/s. Furthermore, we explore tradeoffs between compression quality and FPGA area that allow the same throughput at a fraction of the logic utilization in exchange for moderate reductions in compression quality. Compared to recent FPGA compression studies, our emphasis on scalability gives our accelerator a 3.0× advantage in resource utilization at equivalent throughput and compression ratio.
Using Lexico-Syntactic Ontology Design Patterns for Ontology Creation and Population

In this paper we discuss the use of information extraction techniques involving lexico-syntactic patterns to generate ontological information from unstructured text and either create a new ontology from scratch or augment an existing ontology with new entities. We refine the patterns using a term extraction tool and some semantic restrictions derived from WordNet and VerbNet, in order to prevent the overgeneration that occurs with the use of the Ontology Design Patterns for this purpose. We present two applications developed in GATE and available as plugins for the NeOn Toolkit: one for general use on all kinds of text, and one for specific use in the fisheries domain.
Photoreceptor signalling is sufficient to explain the detectability threshold of insect aerial pursuers

ABSTRACT An essential biological task for many flying insects is the detection of small, moving targets, such as when pursuing prey or conspecifics. Neural pathways underlying such ‘target-detecting’ behaviours have been investigated for their sensitivity and tuning properties (size, velocity). However, which stage of neuronal processing limits target detection is not yet known. Here, we investigated several skilled, aerial pursuers (males of four insect species), measuring the target-detection limit (signal-to-noise ratio) of light-adapted photoreceptors. We recorded intracellular responses to moving targets of varying size, extended well below the nominal resolution of single ommatidia. We found that the signal detection limit (2× photoreceptor noise) matches physiological or behavioural target-detection thresholds observed in each species. Thus, across a diverse range of flying insects, individual photoreceptor responses to changes in light intensity establish the sensitivity of the feature detection pathway, indicating later stages of processing are dedicated to feature tuning, tracking and selection. Summary: Across four insect species, the smallest target size a photoreceptor can robustly encode is sufficient to explain the detection limit of higher-order, target-detecting neurons or observed behavioural pursuits.
Nonconforming Galerkin methods based on quadrilateral elements for second order elliptic problems

Low-order nonconforming Galerkin methods will be analyzed for second-order elliptic equations subjected to Robin, Dirichlet, or Neumann boundary conditions. Both simplicial and rectangular elements will be considered in two and three dimensions. The simplicial elements will be based on P 1 , as for conforming elements; however, it is necessary to introduce new elements in the rectangular case. Optimal order error estimates are demonstrated in all cases with respect to a broken norm in H 1 (Ω) and in the Neumann and Robin cases in L 2 (Ω).
The Physiology and Pathophysiology of the Hyperbaric and Diving Environments Impairment of the autonomic nervous function during decompression sickness in swine

Bai Y, Mahon RT, White JC, Brink PR, Chon KH. Impairment of the autonomic nervous function during decompression sickness in swine. J Appl Physiol 106: 1004–1009, 2009. First published January 8, 2009; doi:10.1152/japplphysiol.91246. 2008. —Dysautonomia has been observed in many cardiac diseases; however, its effect in decompression sickness (DCS) has not been well examined largely due to the difficulty in obtaining experimental data in human or animal subjects. In this study, we examine how DCS affects the autonomic nervous system’s (ANS) dynamics in swine. Baseline and post-DCS electrocardiograms were obtained via telemetry recordings and compared. These data were analyzed using both the power spectrum method and our recently developed principal dynamic mode (PDM) analysis. PDM is able to separate the dynamic tones of the sympathetic and parasympathetic nervous systems. Both methods demonstrated a statistically significant decrease ( 55%; P 0.05) in the dynamics of both branches of the autonomic nervous system in the swine with DCS compared with the control condition. In cardiac diseases such as myocardial infarction, ANS imbalance is often associated with a significant increase in sympathetic tone, which may or may not be counterbalanced by parasympathetic nervous activity. However, the effect of DCS is such that both branches of the ANS are depressed 55% compared with the control condition, suggesting impairment, but not imbalance, of the ANS.
Obesity, Autoimmunity, and Double Diabetes in Youth

A few obese youth with type 2 diabetes have evidence of islet cell autoimmunity with autoantibodies toward β-cells typical of type 1 diabetes defining what is called “double diabetes” (DD). The increasingly “obesogenic” environment that favors insulin resistance could account for the development of islet cell autoimmunity through different mechanisms. Therefore, a rising obesity trend seems to have a role (in association with other environmental factors) in the increasing incidence and the changing phenotype of type 1 diabetes in youth. Over the past decade, it has become apparent that more cases of type 1 diabetes are diagnosed in children and adolescents who were overweight or even obese before hyperglycemia developed. Accordingly, diagnosis of type 1 diabetes is not easy to place because of the phenotypic features typically associated with type 2 diabetes. In addition, the increase of obesity observed in children may contribute to the escalation of β-cell destruction, as suggested by the accelerator hypothesis in subjects genetically susceptible to type 1 diabetes. Lifestyle modifications, including diet and exercise, which are relevant for the prevention of type 2 diabetes, may be important modifiable environmental factors also for type 1 diabetes prevention in subjects with DD. A few years ago, the terms “type 1 diabetes” and “type 2 diabetes” replaced “insulin-dependent diabetes” and “non-insulin-dependent diabetes,” respectively. This new nomenclature reflected two distinct forms of the disease in terms of pathogenesis (1). The classification is still maintained, although other subtypes have been included in the latest classification (2). An increase in blood glucose results either from failure of the β-cells to secrete insulin (type 1 diabetes) or reduction in insulin secretion combined with insulin resistance of peripheral tissues (type 2 diabetes), or a combination of both (3). The prevalence of both types of diabetes is rapidly increasing in industrialized countries, and although …
The Ribosomal Database Project: improved alignments and new tools for rRNA analysis

The Ribosomal Database Project (RDP) provides researchers with quality-controlled bacterial and archaeal small subunit rRNA alignments and analysis tools. An improved alignment strategy uses the Infernal secondary structure aware aligner to provide a more consistent higher quality alignment and faster processing of user sequences. Substantial new analysis features include a new Pyrosequencing Pipeline that provides tools to support analysis of ultra high-throughput rRNA sequencing data. This pipeline offers a collection of tools that automate the data processing and simplify the computationally intensive analysis of large sequencing libraries. In addition, a new Taxomatic visualization tool allows rapid visualization of taxonomic inconsistencies and suggests corrections, and a new class Assignment Generator provides instructors with a lesson plan and individualized teaching materials. Details about RDP data and analytical functions can be found at http://rdp.cme. msu.edu/.
Spatial firing properties of hippocampal theta cells

Previous studies have shown that complex-spike cells, the most common cell type recorded in the hippocampus of freely moving rats, have the property of spatial firing--that is, a cell will fire rapidly only when the animal is in a particular part of its environment (O'Keefe and Dostrovsky, 1971). In the current study, we analyze the spatial firing of theta cells, the second major class of cells in the hippocampus, which are thought to correspond to nonpyramidal neurons (Fox and Ranck, 1975, 1981). Our purposes were to extend findings from earlier spatial analyses (McNaughton et al., 1983; Christian and Deadwyler, 1986), and to determine whether the spatial firing is cell specific and independent of behavior. Theta cells were recorded from rats in a cylindrical enclosure using techniques previously used for the analysis of spatial firing in complex-spike cells (Muller et al., 1987). The spatial firing patterns of individual neurons appeared as a complex surface with several regions of high and low firing. The ratio of firing from high- to low-rate regions averaged 2.5. These spatial firing patterns were smooth and reproducible, but less so than for complex-spike cells. When a cue card on the wall was moved, theta cell firing patterns remained in register with the cue. Two analyses were performed to determine whether spatial firing patterns were secondary to spatial distributions of behavior. When only locomotor data segments were selected, spatial variations were more clear-cut. In an attempt to test whether theta cells had cell-specific patterns of firing, pairs of theta cells were recorded simultaneously. On all occasions, the firing distribution for each of the cells in a pair was clearly distinctive. These findings support the conclusions that theta cell activity contains a spatial signal that is cell specific and not secondary to other firing correlates.
Electronically excited molecular nitrogen and molecular oxygen in the high-latitude upper atmosphere

Relative vibrational populations of triplet B 3 Π g , W 3 Δ,sub> u , B '3 Σ u − states of N 2 and the b 1 Σ g + state of O 2 are calculated for different altitudes of the high-latitude upper atmosphere during auroral electron precipitation. It is shown that collisional processes cause a wavelength shift in the distribution of relative intensities for 1PG Δ v =3 sequence of N 2 . The calculation of relative populations for vibrational levels v =1–5 of the b 1 Σ g + state in the auroral ionosphere has not given an agreement with experimental results. Preliminary estimation of the contribution of the reaction O 2 + +NO to the production of O 2 ( b 1 Σ g + ) on the basis of a quantum-chemical approximation does not allow for an explanation of the observable vibrational population of the b 1 Σ g + state in the aurora.
Evidence of Hermaphroditism and Sex Ratio Distortion in the Fungal Feeding Nematode Bursaphelenchus okinawaensis

Nematodes have many different reproductive strategies along with their divergent life histories; the ability of hermaphrodite to self- and cross-fertilize is useful for genetic manipulation. Here, we demonstrate the hermaphroditism of the fungal feeding nematode Bursaphelenchus okinawaensis, which was formerly described as a parthenogenetic nematode, and we show its other unique sexual characteristics. To determine that it is hermaphroditic, we performed the following experiments: observation of the pronuclear and chromosome behavior during oogenesis and early embryogenesis; observation of spermatogenesis during the fourth larval stage; investigation of sperm utilization; and investigation of phenotypic segregation after cross-mating using a chemically induced visible mutant. We then investigated the mating preferences and spermatid size difference between males and hermaphrodites. B. okinawaensis males successfully mated only with sperm-depleted old hermaphrodites, and the spermatid sizes of males were almost the same as those of hermaphrodites. Moreover, the sex ratio of cross-fertilized progeny was highly skewed toward hermaphrodites. B. okinawaensis is phylogenetically distant from established model nematodes such as C. elegans and is more closely related to some economically relevant parasitic nematodes. This newly discovered hermaphroditic nematode has great potential for evolutionary and parasitological research.
Characterisation of the transcription factor, SIX5, using a new panel of monoclonal antibodies

SIX5 is a member of the human SIX family of transcription factors, many of which are involved in eye development. However, SIX5 transcripts are known to be present at very low levels in cells and no study has yet convincingly demonstrated detection of endogenous SIX5 protein by Western blotting or immunolocalisation. We have produced a new panel of 18 monoclonal antibodies (mAbs) that recognise at least four different epitopes in order to identify authentic human SIX5 protein in cells and tissues. Phage‐displayed peptide libraries were used to identify individual amino‐acids important for antibody binding within each epitope. Endogenous SIX5 migrated in SDS–PAGE with an apparent Mr of 100 kDa and was present at similar levels in all foetal tissues and cell lines tested. In HeLa cells, it was located in the nucleoplasm with a granular distribution. An mRNA for a shorter splicing isoform of SIX5, with an altered carboxy‐terminus, has been described, but further mAbs specific for this isoform did not detect any endogenous protein. We conclude that the full‐length isoform is the major functional protein in vivo while the putative shorter protein is undetectable and may not be expressed at all. © 2005 Wiley‐Liss, Inc.
Locally testable cyclic codes

Cyclic linear codes of block length n over a finite field F/sub q/ are linear subspaces of F/sub q//sup n/ that are invariant under a cyclic shift of their coordinates. A family of codes is good if all the codes in the family have constant rate and constant normalized distance (distance divided by block length). It is a long-standing open problem whether there exists a good family of cyclic linear codes. A code C is r-testable if there exists a randomized algorithm which, given a word x/spl isin//sub q//sup n/, adaptively selects r positions, checks the entries of x in the selected positions, and makes a decision (accept or reject x) based on the positions selected and the numbers found, such that 1) if x/spl isin/C then x is surely accepted; ii) if dist(x,C) /spl ges/ /spl epsi/n then x is probably rejected. ("dist" refers to Hamming distance.) A family of codes is locally testable if all members of the family are r-testable for some constant r. This concept arose from holographic proofs/PCP's. Recently it was asked whether there exist good, locally testable families of codes. In this paper the intersection of the two questions stated is addressed. Theorem. There are no good, locally testable families of cyclic codes over any (fixed) finite field. In fact the result is stronger in that it replaces condition ii) of local testability by the condition ii') if dist (x,C) /spl ges/ /spl epsi/n then x has a positive chance of being rejected. The proof involves methods from Galois theory, cyclotomy, and diophantine approximation.
Legitimizing new practices in primary health care

Background: Finding ways to reinvent primary health care is imperative. One way is to change practices from a physician-focused model to an interdisciplinary team approach where other health professionals (nurses, nurse practitioners, dieticians, rehabilitation therapists, and other qualified primary care providers) collectively take on much stronger roles—often providing services instead of the physician. Health care policy makers and professionals agree that these new practices are a good idea, and yet they have not been widely adopted. Purpose: Our goal was to understand how new interdisciplinary practices became legitimized as the new accepted working standards. Methodology: We conducted a qualitative, longitudinal comparative case study of 8 primary health care innovation sites established to provide services through interdisciplinary teams. We followed changes in practices over a 3-year period by conducting 150 interviews with professionals and managers across the 8 sites. Findings: At the end of 3 years, new practices were adopted in 5 of the sites, but in 3 sites, they were not. We explain the differences by identifying a series of strategies used by managers in the successful sites and compare them with those used in the other 3 sites. Strategies used in the successful sites were (a) gaining full engagement, (b) enticing people to try new practices, (c) encouraging structured disagreement, and (d) staying focused on overall goals. Practice Implications: Managers of health care change initiatives must gain buy-in from professionals, but that is not enough. They must also facilitate trying the new practices as soon as possible. Open disagreement should be carefully encouraged, but any concerns must also be successfully addressed. Finally, managers must keep professionals focused on the overall goals of change rather than allowing paralysis in response to external events.
Optical bound state in the continuum in the one-dimensional photonic crystal slab: Theory and experiment

In this work, we implement CMOS-compatible one-dimensional photonic structure based on silicon-on-insulator wafer supporting optical bound states in the continuum at telecommunication wavelengths - localized optical state with energy lying above the light line of the surrounding space. Such high-Q states are very promising for many potential applications ranging from on-chip photonics and optical communications to biological sensing and photovoltaics.
Not as the crow flies: a historical explanation for circuitous migration in Swainson's thrush (Catharus ustulatus)

Many migratory songbirds follow circuitous migratory routes instead of taking the shortest path between overwintering and breeding areas. Here, we study the migration patterns in Swainson's thrush (Catharus ustulatus), a neartic–neotropical migrant songbird, using molecular genetic approaches. This species is presently separated into genetically distinct coastal and continental populations that diverged during the Late Pleistocene (as indicated by molecular dating), yet appear to have retained ancestral patterns of migration. Low nucleotide diversity, a star–like haplotype phylogeny and unimodal mismatch distributions all support the hypothesis that both the coastal and the continental populations have undergone recent demographic expansions. Nearctic–neotropical banding and genetic data show nearly complete segregation of migratory routes and of overwintering locations: coastal populations migrate along the Pacific Coast to overwintering sites in Central America and Mexico, whereas continental populations migrate along an eastern route to overwintering sites in Panama and South America. Nearctic–neotropical banding data also show that continental birds north, northwest and east of this migratory divide fly thousands of miles east before turning south. We conclude that circuitous migration in the Swainson's thrush is an artefact of a Late Pleistocene range expansion.