Miracle-dz/UniFAR-FTUs huggingface dataset:
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity

During CNS development, the proliferation of progenitors must be coordinated with the pattern of neuronal subtype generation. In the ventral neural tube, Sonic hedgehog acts as a long range morphogen to organise the pattern of cell differentiation by controlling the activity of Gli transcription factors. Here, we provide evidence that the same pathway also acts directly at long range to promote the proliferation and survival of progenitor cells. Blockade of Shh signaling or inhibition of Gli activity results in cell autonomous decreases in progenitor proliferation and survival. Conversely, positive Gli activity promotes proliferation and rescues the effects of inhibiting Shh signaling. Analysis of neural cells indicates that Shh/Gli signaling regulates the G1 phase of cell cycle and the expression of the anti-apoptotic factor Bcl2. Furthermore, Shh signaling independently regulates patterning, proliferation and survival of neural cells, thus Shh/Gli activity couples these separate cellular responses of progenitors to coordinate neural development.
Infectious mononucleosis: appearance of neutralizing antibody to Epstein-Barr virus measured by inhibition of formation of lymphoblastoid cell lines.

Sera taken before illness and during convalescence from patients with infectious mononucleosis (IM) were examined for their ability to neutralize the capacity of Epstein-Barr virus (EBV) to stimulate formation of lymphoblastoid cell lines from human leukocytes in vitro. Neutralizing activity was not detected in 13 of 15 sera taken before illness and was present at a dilution of 1:4 or higher in all of 24 sera taken after illness. EBV-neutralizing activity was found in sera collected during the first week of illness and was also demonstrated in a serum obtained many years after illness. The titer of neutralizing activity in sera of two patients studied sequentially did not change significantly during the first year after IM. The results demonstrate appearance of EBV-neutralizing antibody in IM and support previous seroepidemiologic studies which indicate that EBV is the etiologic agent of IM.
Progressive TextureVideoStreamingfor Lossy

In this work we present an efficient video compression scheme which supports a fast bit rate adaptation independent of the encoder. The proposed scheme generates an embedded bitstream for each frame or, by appropriate multiplexing, for each group of picture. This rate-scalability is supported by an embedded bitstream which allows decoding at multiple rates, or to be more specific at virtually any rate. This video codec is successfully combined with an unequal erasure protection scheme to reduce the effects of packet losses. An optimized rate allocation scheme to trade-off source rate and redundancy is presented. Experimental results show the potential of the presented combination.
Epidemiology of Haemophilus influenzae type b invasive disease in Wales.

OBJECTIVE--To investigate the epidemiology of invasive disease due to Haemophilus influenzae type b, the clones responsible, and the antibiotic resistance of the isolates. DESIGN--Prospective population based analysis of clinical and epidemiological data collected for Gwynedd during 1980-90 and in the whole of Wales during 1988-90. SETTING--19 hospitals in Wales; all medical microbiology laboratories in Wales participated. PATIENTS--82 patients with confirmed invasive infections caused by H influenzae type b in Gwynedd during 1980-90 and 207 in Wales during 1988-90. MAIN OUTCOME MEASURES--Clinical and epidemiological measures; analysis of the clonal types of the isolates based on the electrophoretic mobilities of 17 metabolic enzymes; and antibiotic resistance. RESULTS--The annual incidence of H influenzae type b infections in Gwynedd was 3.2 cases/100,000 and in Wales was 2.5 cases/100,000. Most cases occurred in children aged under 5 years, the highest annual incidence being in those aged under 1 (84.6/100,000 and 56.9/100,000 in Wales). The cumulative risk of acquiring H influenzae type b disease by the fifth birthday was one in 456 in Gwynedd and one in 578 in Wales. Fifteen per cent of cases in Gwynedd and 7% of those in Wales occurred in adults. Predominant clinical conditions were meningitis in children and pneumonia in adults. In Gwynedd 2/70 (3%) children and 5/12 (42%) adults died. Long term neurological sequelae occurred in 8% (4/48) of children who survived haemophilus meningitis. Children presenting with infection were usually the youngest members of their family. No secondary household cases were identified. 100 of 128 (78%) strains were of a single clone, electrophoretic type 12.5, and 4/207 (1.9%) isolates from Wales were resistant to both ampicillin and chloramphenicol. CONCLUSIONS--The annual rate of infection in children aged under 5 in four Welsh counties was 12-44% higher than that previously published for the United Kingdom. The study emphasises the potential value of a vaccine effective in early infancy and provides baseline data to assess its efficacy after its introduction. Alternatives to ampicillin and chloramphenicol should be used as first line, empirical treatment for severe infections that might be caused by H influenzae type b in Wales.
Telling Tales: Enacting Family Relationships in Joint Storytelling About Difficult Family Experiences

Narratives help people make sense of difficult experiences. In addition, stories provide insight into people's conceptualizations of the world, including their understanding of their family relationships. Given these two functions of storytelling, the ways in which family members tell stories about difficult experiences together should reveal or reflect relational qualities. This project focused on how the family relational context relates to jointly-enacted sense-making behaviors as families tell stories of shared difficult experiences. Findings indicate that interactional sense-making behaviors, in particular coherence and perspective-taking, predict important family relational qualities. This suggests that family qualities affect and are reflected in the likelihood that family members will engage in productive sense-making behaviors as a unit when talking about a shared difficult experience.
Early years, low status? Early years teachers' perceptions of their occupational status

Using survey and interview data from the Teacher Status Project, this paper explores early years teachers' sense of status and compares it with primary and secondary teachers' perceived status. If, as Hoyle has suggested, working with children is an intractable barrier to enhanced status in the eyes of the public, early years teachers are faced with the greatest challenge. At the same time, their closer links with parents and community affords them more opportunity to enhance the esteem in which they are held through the way that they do their work. The data seem to support this view, but it is argued that whilst curriculum guidance, and the recognition of the Foundation Stage have enhanced these teachers' sense of status in the public eye, the effects of the ten‐year strategy could undermine this progress unless an emphasis is placed on the teaching, pedagogical element of their specialist expertise.
Making museum tours better: understanding what a guided tour really is and what a tour guide really does

Tour guiding is much-practised and yet little-studied, particularly within the museum sector. Consequently, we have little understanding of the nature of guided tours and this results in untested assumptions forming the basis of training and practice. Because of this lack of knowledge, we cannot capitalise on the opportunities that tours present for museums to engage with their publics; nor can we counteract the challenges which their design and delivery present for the contemporary museum. This article uses detailed studies of guides-in-practice to show that tours are highly interactive pursuits, as opposed to the somewhat pre-scripted ‘lectures’ that they are often considered to be. As such, this paper intends to respecify what a tour is, how guides are trained and managed, and how electronic museum guides are designed and deployed.
Characteristics of diffuse large B cell lymphomas in rheumatoid arthritis.

OBJECTIVE Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas, with a correlation between RA disease severity and lymphoma risk, most pronounced for diffuse large B cell lymphomas (DLBCLs), which also constitute the majority of RA-associated lymphomas. DLBCLs can be further subdivided into germinal center (GC)-like and non-GC-like subtypes, with different cellular origins and prognoses. This study was undertaken to investigate whether RA displays a specific association with any of the DLBCL subtypes. METHODS We identified 139 patients with DLBCLs within a population-based case-control study of 378 RA patients with lymphoma. The DLBCLs were examined for CD10, Bcl-6, and interferon regulatory factor 4 expression patterns, subclassified into GC and non-GC subtypes, and then correlated with clinical parameters. RESULTS We found a statistically significant predominance of the non-GC subtype (97 patients; 70% of all DLBCLs). These patients more often had an advanced stage of lymphoma at diagnosis and had a worse 5-year overall survival rate (16% versus 33%) compared with patients with the GC subtype. There was a strong association with RA disease activity in both subtypes, with >70% of the GC and non-GC cases occurring in RA patients with the highest overall disease activity scores. CONCLUSION These findings suggest that severe RA is particularly associated with the non-GC subtype of DLBCL, and indicate a critical role of activated peripheral B cells as the cells of origin in these lymphomas.
Sustainable leadership : honeybee practices at a leading Asian industrial conglomerate

Purpose – Avery and Bergsteiner's updated set of 23 sustainable leadership practices derived from sustainable enterprises and five performance outcomes provides a framework to examine the business practices of Thailand's largest conglomerate, Siam Cement Group (SCG). The aim of this paper is to build on and expand Kantabutra and Avery's study based on Avery.Design/methodology/approach – The analysis was conducted by grouping Avery and Bergsteiner's principles into six categories, namely taking a long‐term perspective, investing in people, adapting the organizational culture, being innovative, exhibiting social and environmental responsibility, and behaving ethically. Adopting a multi‐data collection approach, research teams supplemented case study data with non‐participant observations from visits to the conglomerate and its training sessions. Multiple stakeholders were interviewed in semi‐structured interviews. Documentation and information supplied by, or published about, the conglomerate was consulted.
Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement1

In this study, using a soluble CD200-Ig fusion protein, we provide evidence that murine dendritic cells (DCs) possess a functional CD200R, whose engagement results in the reinforcement or appearance of immunosuppressive properties in these cells. In particular, the plasmacytoid subset (CD11c+B220+120G8+) of splenic DCs (pDCs) is induced by CD200-Ig to express the enzyme IDO, which initiates the tolerogenic pathway of tryptophan catabolism. As a result, pDCs are capable of suppressing Ag-specific responses in vivo when transferred into recipient hosts after treatment with CD200-Ig. IDO induction in pDCs through CD200R engagement requires type I IFNR signaling. Although the release of IFN-α may contribute to the full expression of CD200-Ig activity, autocrine IFN-α is unlikely to mediate alone the effects of CD200R engagement. These data prospect novel functions for both pDCs and the CD200-CD200R pair in the mouse. At the same time, these data underscore the possible unifying role of the IDO mechanism in immune tolerance.
Concurrent design happens at the interfaces

Abstract Concurrent engineering is often viewed either from a technical point of view—that is, as a problem that can be solved by creating and integrating computer-based tools—or from an organizational point of view—that is, as a problem that can be solved by creating and reorganizing teams of designers. In this paper we argue that concurrent engineering requires both technical and organizational solutions, and we call the result concurrent design. We believe that the essence of concurrent design is the myriad of interactions that occur at the interfaces among all of the members of a design team and all their tools. Solving either the technical or organizational problems by assuming away the interactions will not solve the problems of concurrent design. In this paper we present two case studies of concurrent design in practice that have changed our assumptions about design and which have changed our research agenda. We also present the evolution of concurrent design research at the Carnegie Mellon Engineering Design Research Center. In our research, we have designed, manufactured, and used our own tools as well as observed their use by others—where the tools include mobile computers, design analysis programs, and information organization tools. Through this process, we have learned about design education and design practice, and we have uncovered new issues for design research. We see the interactions among design research, practice, and education as essential to understanding concurrent design.
The Effects of Knowledge, Motivation, and Type of Message on Ad Processing and Product Judgments

We examined the effects of knowledge, motivation, and the type of message on ad processing and on product judgments. The data suggest that, regardless of subjects' prior knowledge, they could be motivated to process message information in detail. However, experts and novices differed in the types of information that prompted detailed message processing. Experts are more likely to process a message in detail when given only attribute information, while novices are more likely to do so when given benefit (or benefit and attribute) information. Experts and novices also differed in how they processed messages; experts' detailed message processing was evaluative, while novices' was more literal. Copyright 1990 by the University of Chicago.
Iceland and the Nordic Model of Consensus Democracy

The Nordic countries – including Iceland – have been portrayed in the political-science literature as consensual democracies, enjoying a high degree of legitimacy and institutional mechanisms which favour consensus-building over majority rule and adversarial politics. In this explorative article the author argues that consensus politics, meaning policy concertation between major interest groups in society, a tendency to form broad coalitions in important political issues and a significant cooperation between government and opposition in Parliament, is not an apt term to describe the political reality in Iceland during the second half of the 20th century. Icelandic democracy is better described as more adversarial than consensual in style and practice. The labour market was rife with conflict and strikes more frequent than in Europe, resulting in strained government–trade union relationship. Secondly, Iceland did not share the Nordic tradition of power-sharing or corporatism as regards labour market policies or macro-economic policy management, primarily because of the weakness of Social Democrats and the Left in general. Thirdly, the legislative process did not show a strong tendency towards consensus-building between government and opposition with regard to government seeking consultation or support for key legislation. Fourthly, the political style in legislative procedures and public debate in general tended to be adversarial rather than consensual in nature.
Surgical treatment of lower limb ischemia in diabetic patients – long-term results

Introduction Lower limb ischemia may cause nonhealing ulcers, infection, amputation and even mortality in diabetic patients. In this study, we review our data of ischemic lower limb revascularization procedures in diabetic patients and present the early, mid- and long-term results. Material and methods From March 2004 to September 2008, 83 patients with lower limb ischemia in Fontaine class III and IV underwent distal arterial bypass procedures. Saphenous vein grafts were used for below-knee arterial bypasses in all patients. In 16 (19%) patients femoropopliteal bypasses were performed with PTFE grafts. Short-term and long-term surgical results were evaluated. Results Ulcer recovery was determined in 36% of patients. Graft patency was 95% and 1 death (1%) occurred in short-term follow-up. In long-term follow-up the total effectiveness rate was 74%. Graft patency was 79% and 6 deaths (7%) occurred during the follow-up. Conclusions Lower limb ischemia is a serious event in patients with diabetes mellitus. The consequences may include increased mortality and morbidity in this particular patient population. However, distal arterial revascularizations are considerably effective procedures to avoid amputation, to eliminate symptoms, to promote ulcer recovery and to help the patient participate in social life with acceptable short, mid- and long-term follow-up results.
Clearing the Fog

This study presents parallel perspectives of a novice teacher's struggle to improve his teaching during his third year as an elementary string teacher. Throughout that year, Jelani met with and was observed by his school district supervisor and a faculty member at the local university. All three of us agreed that we wanted Jelani to succeed, yet we each felt as if wandering in a dense fog, unable to discern a clear route to the hoped-for outcome. Alternating between our voices, we tell the stories of our individual experiences as we worked together, creating here the story of our shared journey through gradually lifting haze. We identified four elements that helped disperse the fog: Jelani's increasing pedagogical content knowledge, his self-confidence and persistence, the opportunity for Jelani to work in the university's String Project classes, and the supervisor's mentoring style.
Lifetime nonnarcotic analgesic use and decline in renal function in women.

BACKGROUND Analgesics are commonly used and may impair kidney function. However, limited prospective information is available on the long-term effects of aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen on renal function. METHODS A total of 1697 women participating in the Nurses' Health Study provided information on a mailed questionnaire in 1999 about lifetime use of acetaminophen, aspirin, and NSAIDs and provided blood samples in 1989 and 2000. The main outcome was change in estimated glomerular filtration rate (GFR) in 11 years. Multivariate logistic regression was used to determine the odds of developing the outcome according to lifetime analgesic intake. RESULTS The mean +/- SD estimated GFR decreased from 88 +/- 17 to 79 +/- 17 mL/min per 1.73 m(2). There were no substantial differences in the unadjusted or estimated GFR levels among the categories of lifetime intake for the 3 analgesic groups at baseline or after 11 years. Acetaminophen use was associated with an increased risk of a GFR decline of at least 30 mL/min per 1.73 m(2) (P trend =.01) and a GFR decline of 30% or greater (P trend<.001), but aspirin and NSAID use were not. Compared with women consuming less than 100 g of acetaminophen, multivariate-adjusted odds ratio (95% confidence intervals) for a decline in GFR of at least 30 mL/min per 1.73 m(2) for women consuming more than 3000 g was 2.04 (1.28-3.24). CONCLUSIONS Higher lifetime use of aspirin and NSAIDs is not associated with renal function decline, but high acetaminophen use may increase the risk of loss of renal function. The absolute risk of renal function decline due to even high lifetime analgesic intake seems to be modest.
Discounting and Averaging in Games across Time scales

We introduce two-level discounted and mean-payoff games played by two players on a perfect-information stochastic game graph. The upper level game is a discounted or mean-payoff game and the lower level game is a (undiscounted) reachability game. Two-level games model hierarchical and sequential decision making under uncertainty across different time scales. For both discounted and mean-payoff two-level games, we show the existence of pure memoryless optimal strategies for both players and an ordered field property. We show that if there is only one player (Markov decision processes), then the values can be computed in polynomial time. It follows that whether the value of a player is equal to a given rational constant in two-level discounted or mean-payoff games can be decided in NP ∩ coNP. We also give an alternate strategy improvement algorithm to compute the value.
A Commentary and an Overview of Key Questions on Corporate Social Performance Measurement

This article has two purposes. First, the author will provide a commentary on Donna Wood’s article on theory, research, passion, and integrity in business and society. This is in response to an invitation to serve as a raconteur onWood’s article. In fulfilling this role, the author will provide summary comments and then remark on each major section of her article. She provides a helpful and engaging overview of the business and society field that provides a backdrop for a consideration of Corporate Social Performance (CSP) theory and measurement. Second, the author will present what he considers to be a few key questions or issues that need to be addressed as we seek to advance CSP measurement.