Miracle-dz/UniFAR-FTUs huggingface dataset:
Patterns of Species Ranges, Speciation, and Extinction

The exact nature of the relationship among species range sizes, speciation, and extinction events is not well understood. The factors that promote larger ranges, such as broad niche widths and high dispersal abilities, could increase the likelihood of encountering new habitats but also prevent local adaptation due to high gene flow. Similarly, low dispersal abilities or narrower niche widths could cause populations to be isolated, but such populations may lack advantageous mutations due to low population sizes. Here we present a large-scale, spatially explicit, individual-based model addressing the relationships between species ranges, speciation, and extinction. We followed the evolutionary dynamics of hundreds of thousands of diploid individuals for 200,000 generations. Individuals adapted to multiple resources and formed ecological species in a multidimensional trait space. These species varied in niche widths, and we observed the coexistence of generalists and specialists on a few resources. Our model shows that species ranges correlate with dispersal abilities but do not change with the strength of fitness trade-offs; however, high dispersal abilities and low resource utilization costs, which favored broad niche widths, have a strong negative effect on speciation rates. An unexpected result of our model is the strong effect of underlying resource distributions on speciation: in highly fragmented landscapes, speciation rates are reduced.
Lipid-lowering drugs associated with slower motor decline in the elderly adults.

BACKGROUND Vascular risk factors contribute to motor decline in the elderly persons. We investigated the relationship between lipid-lowering drugs (LLDs) use and decline in walking speed (WS) in older adults. METHODS Data on 4,009 community-dwelling men and women, aged ≥65 years at baseline, are drawn from the Dijon (France) center of the Three-City study. "Fast" WS was assessed over 6 m at baseline and at 4, 6, 8, and 10 years of follow-up. Mixed linear models were used to determine the relationship between LLDs and change in WS over the follow-up. RESULTS At baseline, 1,295 (32%) participants used LLDs (statins, n = 643; fibrates, n = 652); mean fast WS was 152.9cm/s and not significantly different between LLDs users and nonusers. In models adjusted for age, sex, cholesterol level, and other covariates, WS decline was 25% slower in LLDs users (difference with nonusers: 0.58cm/s/y, 95% CI: 0.30, 0.86; p < .001). Both fibrates and statins were associated with slower decline, but only the effect of statins was robust in analyses that took missing values into account. The beneficial effect was more pronounced in those on LLDs continuously over the follow-up. CONCLUSION Fast WS declined less in those on LLDs, suggesting that the effect of LLDs, statins in particular, extend beyond that on cardiovascular disease in the elderly persons. However, these effects were modest and their clinical relevance is unclear.
Has the Propensity to Pay Out Declined?

Abstract Recent studies document both a significant decline in firms’ propensity to pay dividends and a significant increase in firms’ propensity to repurchase shares and issue equity over the past 30 years. In this paper we test whether firms’ net cash disbursements to equity holders have declined in a pattern similar to firms’ propensity to pay dividends. Contrary to the evidence using dividends, we find no evidence that the conditional propensity to distribute net cash to equity holders has declined over the past 3 decades. Surprisingly, we find that, conditional on firm characteristics, net payout yields have been increasing over time.
Pterocarpanquinone LQB-118 Induces Apoptosis in Leishmania (Viannia) braziliensis and Controls Lesions in Infected Hamsters

Previous results demonstrate that the hybrid synthetic pterocarpanquinone LQB-118 presents antileishmanial activity against Leishmania amazonensis in a mouse model. The aim of the present study was to use a hamster model to investigate whether LQB-118 presents antileishmanial activity against Leishmania (Viannia) braziliensis, which is the major Leishmania species related to American tegumentary leishmaniasis. The in vitro antileishmanial activity of LQB-118 on L. braziliensis was tested on the promastigote and intracellular amastigote forms. The cell death induced by LQB-118 in the L. braziliensis promastigotes was analyzed using an annexin V-FITC/PI kit, the oxidative stress was evaluated by 2′,7′-dichlorodihydrofluorescein diacetate (H2DCFDA) and the ATP content by luminescence. In situ labeling of DNA fragments by terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) was used to investigate apoptosis in the intracellular amastigotes. L. braziliensis-infected hamsters were treated from the seventh day of infection with LQB-118 administered intralesionally (26 µg/kg/day, three times a week) or orally (4,3 mg/kg/day, five times a week) for eight weeks. LQB-118 was active against the L. braziliensis promastigotes and intracellular amastigotes, producing IC50 (50% inhibitory concentration) values of 3,4±0,1 and 7,5±0,8 µM, respectively. LQB-118 induced promastigote phosphatidylserine externalization accompanied by increased reactive oxygen species production and ATP depletion. Intracellular amastigote DNA fragmentation was also observed, without affecting the viability of macrophages. The treatment of L. braziliensis-infected hamsters with LQB-118, either orally or intralesionally, was effective in the control of lesion size, parasite load and increase intradermal reaction to parasite antigen. Taken together, these results show that the antileishmanial effect of LQB-118 extends to L. braziliensis in the hamster model, involves the induction of parasite apoptosis and shows promising therapeutic option by oral or local routes in leishmaniasis.
Preferred Arguments are Harder to Compute than Stable Extension

Based on an abstract framework for nonmonotonic reasoning, Bondarenko et at. have extended the logic programming semantics of admissible and preferred arguments to other nonmonotonic formalisms such as circumscription, autoepisternic logic and default logic. Although the new semantics have been tacitly assumed to mitigate the computational problems of nonmonotonic reasoning under the standard semantics of stable extensions, it seems questionable whether they improve the worst-case behaviour. As a matter of fact, we show that credulous reasoning under the new semantics in propositional logic programming and prepositional default logic has the same computational complexity as under the standard semantics. Furthermore, sceptical reasoning under the admissibility semantics is easier - since it is trivialised to monotonic reasoning. Finally, sceptical reasoning under the preferability semantics is harder than under the standard semantics.
Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the adult trout and tract‐tracing observations on the connections of the nuclei of the isthmus

The distribution of cholinergic neurons and fibers was studied in the brain and rostral spinal cord of the brown trout and rainbow trout by using an antiserum against the enzyme choline acetyltransferase (ChAT). Cholinergic neurons were observed in the ventral telencephalon, preoptic region, habenula, thalamus, hypothalamus, magnocellular superficial pretectal nucleus, optic tectum, isthmus, cranial nerve motor nuclei, and spinal cord. In addition, new cholinergic groups were detected in the vascular organ of the lamina terminalis, the parvocellular and magnocellular parts of the preoptic nucleus, the anterior tuberal nucleus, and a mesencephalic tegmental nucleus. The presence of ChAT in the magnocellular neurosecretory system of trout suggests that acetylcholine is involved in control of hormone release by neurosecretory terminals. In order to characterize the several cholinergic nuclei observed in the isthmus of trout, their projections were studied by application of 1,1`‐dioctadecyl‐3,3,3`,3`‐tetramethylindocarbocyanine perchlorate (DiI) to selected structures of the brain. The secondary gustatory nucleus projected mainly to the lateral hypothalamic lobes, whereas the nucleus isthmi projected to the optic tectum and parvocellular superficial pretectal nucleus, as previously described in other teleost groups. In addition, other isthmic cholinergic nuclei of trout may be homologs of the mesopontine system of mammals. We conclude that the cholinergic systems of teleosts show many primitive features that have been preserved during evolution, together with characteristics exclusive to the group. J. Comp. Neurol. 428:450–474, 2000. © 2000 Wiley‐Liss, Inc.
Eyes on the Prize: A Longitudinal Study of Action–State Orientation, Affect, and Academic Self-Regulation

Abstract Action–state orientation (ASO) describes the ability to plan, initiate, and complete intended activities. Action-oriented individuals, compared to state-oriented, are better able to focus their efforts and therefore move toward goals. While Kuhl (1994) posits that affect mediates the relationship between personality traits like ASO and successful self-regulation, ASO scholarship rarely examines the role of affect, and no ASO studies have examined self-regulation over time. We address these limitations by examining students’ academic self-regulation over a semester. HLM analyses show that action- versus state-oriented people exhibit better academic self-regulation as expected. However, we found no support for affect as a mediator.
The Impact of Immigration on the Structure of Male Wages: Theory and Evidence from Britain

Immigration to the UK has risen in the past 10 years and has had a measurable effect on the supply of different types of labour. But, existing studies of the impact of immigration on the wages of native-born workers in the UK (e.g. Dustmann, Fabbri and Preston, 2005) have failed to find any significant effect. This is something of a puzzle since Card and Lemieux, (2001) have shown that changes in the relative supply of educated natives do seem to have measurable effects on the wage structure. This paper offers a resolution of this puzzle – natives and immigrants are imperfect substitutes, so that an increase in immigration reduces the wages of immigrants relative to natives. We show this using a pooled time series of British cross-sectional micro data of observations on male wages and employment from the mid-1970s to the mid-2000s. This lack of substitution also means that there is little discernable effect of increased immigration on the wages of native-born workers.
Prediction and management of drug reaction with eosinophilia and systemic symptoms (DRESS)

Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a lifethreatening, drug-induced, multi-organ system reaction, which is characterized by sequential reactivations of herpesviruses [1,2]. Because this syndrome is initiated by fever of >38°C and maculopapular morbilliform exanthema, viral infections could be a potential consideration at onset. The delayed onset of clinical symptoms of DiHS/DRESS, usually 2–6 weeks after starting therapy, often causes the potential diagnostic delay (Figure 1). Paradoxical worsening of clinical symptoms often occurs 3–4 days after withdrawal of the causative drug, a quite unusual finding for drug eruption: owing to increasing concern of infections, unnecessary empirical antibiotic therapy may be started, thereby increasing the risk of developing additional sensitization to these drugs. Importantly, patients with DiHS/DRESS often show unexplained cross-reactivity to multiple drugs with different chemical structures, including nonsteroidal anti-inflammatory drugs (NSAIDs) [1,3]. A detailed drug history is very important to identify the causative drugs. This editorial presents a management-based approach to the diagnosis and treatment.
Risk of reading difficulty among students with a history of speech or language impairment: Implications for Student Support Teams

ABSTRACT Many students with a history of speech or language impairment have an elevated risk of reading difficulty. Specific subgroups of these students remain at risk of reading problems even after clinical manifestations of a speech or language disorder have diminished. These students may require reading intervention within a general education system of supports and services. The first part of this article describes three speech-language disorders that place elementary students at risk of reading problems: functional speech disorders, childhood apraxia of speech, and specific language impairment. Emphasis is given to research findings on the reading outcomes of students with these disorders. The second part of the article provides recommendations within an RTI framework that will assist Student Support Teams in identifying, monitoring, and supporting these students.
Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation

Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), is associated with obesity and metabolic disorders. The mass and function of adipose tissue are largely dependent on adipogenesis. The impact of low-frequency IH on adipogenesis is unknown. Sprague-Dawley rats were subjected to IH (4 min for 10% O2 and 2 min for 21% O2) or intermittent normoxia (IN) for 6 weeks. The degree of adipogenic differentiation was evaluated by adipogenic transcriptional factors, adipocyte-specific proteins, and oily droplet production in both subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). Upregulation of proadipogenic markers (CEBPα, PPARγ, and FABP4) and downregulation of antiadipogenic markers CHOP in line with smaller size of adipocytes were found in IH-exposed SAT. In vitro experiments using human preadipocytes (HPAs) of subcutaneous lineage during differentiation phase, subjected to IH (1% O2 for 10 min and 21% O2 for 5 min; 5% CO2) or IN treatment, were done to investigate the insulin-like growth factor 1 receptor (IGF-1R)/Akt pathway in adipogenesis. IH promoted the accumulation of oily droplets and adipogenesis-associated markers. IGF-1R kinase inhibitor NVP-AEW541 attenuated the proadipogenic role in IH-exposed HPAs. In summary, relatively low frequency of IH may enhance adipogenesis preferentially in SAT.
Telecommuting, Residential Location, and Commute-Distance Traveled: Evidence from State of California Employees

This study analyzes retrospective data on telecommuting and residential and job location changes over a ten-year period, from 218 employees (62 current telecommuters, 35 former telecommuters, and 121 people who had never telecommuted) of six California state government agencies which had actively participated in the well-known pilot program of 1988–90. We compare estimates of the total commute person-miles traveled by telecommuters with those of nontelecommuters, on a quarterly basis. Key findings include the following. One-way commute distances were higher for telecommuters than for nontelecommuters, consistent with prior empirical evidence and with expectation. Average telecommuting frequency declined over time; several explanations are proposed, but cannot be properly tested with these data. The first two findings notwithstanding, the average quarterly per capita total commute distances were generally lower for telecommuters than for nontelecommuters, indicating that they telecommute often enough to more than compensate for their longer one-way commutes. We cannot say from these results whether the ability to telecommute is itself prompting individuals to move farther away, or whether telecommuting is simply more attractive to people who already live farther from work for other reasons. Even if the first is true, however, and telecommuting is the ‘problem’, it also appears to be the solution: that is, it enables people to achieve a desired but more distant residential location without a net increase in commute travel.
Knowledge organization needs epistemological openness: a reply to Peter Jaenecke

This paper is put up to enter into a discussion about the theses of Peter Jaenecke in Knowl.Org. 94-1. Jaenecke's differentiation of knowledge as «core knowledge», «peripheral knowledge», and «pseudo knowledge» is rejected, since his conception of knowledge is limited to a particular epistemology and knowledge domain. The author argues in favor of an epistemologically open conception of knowledge organization considering knowledge organization as a user-supporting but not as a user and producer controlling task
Separate Perceptual and Neural Processing of Velocity- and Disparity-Based 3D Motion Signals

Although the visual system uses both velocity- and disparity-based binocular information for computing 3D motion, it is unknown whether (and how) these two signals interact. We found that these two binocular signals are processed distinctly at the levels of both cortical activity in human MT and perception. In human MT, adaptation to both velocity-based and disparity-based 3D motions demonstrated direction-selective neuroimaging responses. However, when adaptation to one cue was probed using the other cue, there was no evidence of interaction between them (i.e., there was no “cross-cue” adaptation). Analogous psychophysical measurements yielded correspondingly weak cross-cue motion aftereffects (MAEs) in the face of very strong within-cue adaptation. In a direct test of perceptual independence, adapting to opposite 3D directions generated by different binocular cues resulted in simultaneous, superimposed, opposite-direction MAEs. These findings suggest that velocity- and disparity-based 3D motion signals may both flow through area MT but constitute distinct signals and pathways. SIGNIFICANCE STATEMENT Recent human neuroimaging and monkey electrophysiology have revealed 3D motion selectivity in area MT, which is driven by both velocity-based and disparity-based 3D motion signals. However, to elucidate the neural mechanisms by which the brain extracts 3D motion given these binocular signals, it is essential to understand how—or indeed if—these two binocular cues interact. We show that velocity-based and disparity-based signals are mostly separate at the levels of both fMRI responses in area MT and perception. Our findings suggest that the two binocular cues for 3D motion might be processed by separate specialized mechanisms.
How effective are Los Angeles elementary teachers and schools

This study uses value-added methods to examine the effectiveness of Los Angeles elementary teachers and schools. The results show that teacher effectiveness varies substantially across the school district. Most of the variance in teacher effectiveness is within schools and not across schools. Traditional measures of teacher quality like experience and advanced degrees are weakly related to teacher effectiveness. Teacher effectiveness is more variable in mathematics than in language arts.
On the other hand: implications of the study of South African sign language for the education of the deaf in South Africa

This article reports on the major themes that have emerged in the South African Sign Language Research Programme jointly sponsored by the South African National Council for the Deaf, the Human Science Research Council, and the University of the Witwatersrand. The article offers some preliminary observations about the nature of South African Sign Language, the research methodologies utilised in the collection of data, and the significance of the results obtained for the education of deaf persons in the new South Africa
Protease-Activated Receptor-1 and Platelet-Derived Growth Factor in Spinal Cord Neurons Are Implicated in Neuropathic Pain after Nerve Injury

Recently, it has been reported that both thrombin-sensitive protease-activated receptor 1 (PAR-1) and platelet-derived growth factor (PDGF) are present not only in platelets, but also in the CNS, which indicates that they have various physiological functions. In this study, we evaluated whether PAR-1/PDGF in the spinal cord could contribute to the development of a neuropathic pain-like state in mice. Thermal hyperalgesia and tactile allodynia induced by sciatic nerve ligation were significantly suppressed by repeated intrathecal injection of hirudin, which is characterized as a specific and potent thrombin inhibitor. Furthermore, a single intrathecal injection of thrombin produced long-lasting hyperalgesia and allodynia, and these effects were also inhibited by hirudin in normal mice. In nerveligated mice, the increase in the binding of [35S]GTPγS to membranes of the spinal cord induced by thrombin and PAR-1-like immunoreactivity (IR) in the spinal cord were each greater than those in sham-operated mice. Thermal hyperalgesia and tactile allodynia induced by sciatic nerve ligation were also suppressed by repeated intrathecal injection of either the PDGF α receptor (PDGFRα)/Fc chimera protein or the PDGFR-dependent tyrosine kinase inhibitor AG17 [(3,5-di-tert-butyl-4-hydroxybenzylidene)-malononitrile]. Moreover, thermal hyperalgesia and tactile allodynia induced by thrombin in normal mice were virtually eliminated by intrathecal pretreatment with PDGFRα/Fc. In immunohistochemical studies, PAR-1-like IR-positive cells in the spinal dorsal horn were mostly colocated on PDGF-like IR-positive neuronal cells. These data provide novel evidence that PAR-1 and PDGF-A-mediated signaling pathway within spinal cord neurons may be directly implicated in neuropathic pain after nerve injury in mice.
Surgery for chronic subdural hematoma in nonagenarians: A Scandinavian population‐based multicenter study

Chronic subdural hematoma (cSDH) is a prevalent condition often seen in the elderly, with surgery being the treatment of choice when symptomatic. So far, few have explored the surgical outcomes in patients 90 years or older. The aim of this study was to investigate outcome after cSDH surgery in nonagenarians (≥90 y/o group) compared to younger adult patients (<90 y/o group).
Relativistic Effects on the Observed AGN Luminosity Distribution and Spectral Shape of Seyfert Galaxies

Recently, Zhang (2005 ApJ, 618, L79) has proposed a model to account for the well-established effect that the fraction of type-II AGNs is anti-correlated with the observed X-ray luminosity; the model consists of an X-ray emitting accretion disk coaligned to the dusty torus within the standard AGN unification model. In this paper the model is refined by including relativistic effects of the observed X-ray radiation from the vicinity of the supermassive black hole in an AGN. The relativistic corrections improve the combined fitting results of the observed luminosity distribution and the type-II AGN fraction, though the improvement is not significant. The type-II AGN fraction prefers non- or mildly spinning black hole cases, and rules out the extremely spinning case.