Miracle-dz/UniFAR-FTUs huggingface dataset:
Tensile and superelastic fatigue characterization of NiTi shape memory cables

This paper discusses the tensile response and functional fatigue characteristics of a NiTi shape memory alloy (SMA) cable with an outer diameter of 5.5 mm. The cable composed of multiple strands arranged as one inner core and two outer layers. The results of the tensile tests revealed that the SMA cable exhibits good superelastic behavior up to 10% strain. Fatigue characteristics were investigated under strain amplitudes ranging from 3% to 7% and a minimum of 2500 loading cycles. The evolutions of maximum tensile stress, residual strains, energy dissipation, and equivalent viscous damping under a number of loading cycles were analyzed. The fracture surface of a specimen subjected to 5000 loading cycles and 7% strain was discussed. Functional fatigue test results indicated a very high superelastic fatigue life cycle for the tested NiTi SMA cable.
Durable engraftment of genetically modified FVIII‐secreting autologous bone marrow stromal cells in the intramedullary microenvironment

Genetically modified FVIII‐expressing autologous bone marrow‐derived mesenchymal stromal cells (BMSCs) could cure haemophilia A. However, culture‐expanded BMSCs engraft poorly in extramedullary sites. Here, we compared the intramedullary cavity, skeletal muscle, subcutaneous tissue and systemic circulation as tissue microenvironments that could support durable engraftment of FVIII‐secreting BMSC in vivo. A zinc finger nuclease integrated human FVIII transgene into PPP1R12C (intron 1) of culture‐expanded primary canine BMSCs. FVIII‐secretory capacity of implanted BMSCs in each dog was expressed as an individualized therapy index (number of viable BMSCs implanted × FVIII activity secreted/million BMSCs/24 hours). Plasma samples before and after implantation were assayed for transgenic FVIII protein using an anti‐human FVIII antibody having negligible cross‐reactivity with canine FVIII. Plasma transgenic FVIII persisted for at least 48 weeks after implantation in the intramedullary cavity. Transgenic FVIII protein levels were low after intramuscular implantation and undetectable after both intravenous infusion and subcutaneous implantation. All plasma samples were negative for anti‐human FVIII antibodies. Plasma concentrations and durability of transgenic FVIII secretion showed no correlation with the therapy index. Thus, the implantation site microenvironment is crucial. The intramedullary microenvironment, but not extramedullary tissues, supported durable engraftment of genetically modified autologous FVIII‐secreting BMSCs.
Optimal design and evaluation of survivable WDM transport networks

This paper proposes an optimal design scheme for survivable wavelength-division multiplexing (WDM) transport networks in which fast restoration can be achieved by using predetermined restoration paths that are independent of failure locations and which have one to one correspondence with working paths. Integer programming-based design problems are formulated to optimally determine working and their corresponding restoration paths, the number of fibers in each span, and the number of optical cross connects (OXCs) in each node. In these optimization problems, total facility cost, which includes not only transmission cost but also cross connection, is minimized. This design scheme can handle the dedicated/shared allocation of spare resources and several parameters, such as the maximum available number of wavelengths per fiber /spl Omega/, the matrix size of each OXC, and cross-connection to transmission cost-coefficient ratio /spl gamma/. Total fiber length, the total number of OXCs, etc., are evaluated from obtained design results for these options and parameters. Numerical examples show that the dependency of total fiber length and the total number of OXCs on /spl gamma/ is relatively small, and cross-connection to transmission cost ratios (/spl gamma/ times the total number of OXCs divided by total fiber length) in the dedicated and shared cases are almost the same for each combination of /spl gamma/ and /spl Omega/.
Hesperidin Displays Relevant Role in the Nutrigenomic Effect of Orange Juice on Blood Leukocytes in Human Volunteers: A Randomized Controlled Cross-Over Study

Background We previously showed, in healthy, middle-aged, moderately overweight men, that orange juice decreases diastolic blood pressure and significantly improves postprandial microvascular endothelial reactivity and that hesperidin could be causally linked to the observed beneficial effect of orange juice. The objective was to determine the effect of chronic consumption of orange juice on the gene expression profile of leukocytes in healthy volunteers and to assess to what extent hesperidin is involved in the effect of orange juice. Methodology/Principal Findings Volunteers were included in a randomized, controlled, crossover study. Throughout three 4-week periods, volunteers consumed daily: 500 ml orange juice, 500 ml control drink plus hesperidin or 500 ml control drink and placebo. Blood samplings were performed on 10 overnight-fasted subjects after the 4-week treatment period. Global gene expression profiles were determined using human whole genome cDNA microarrays. Both orange juice and hesperidin consumption significantly affected leukocyte gene expression. Orange juice consumption induced changes in expression of, 3,422 genes, while hesperidin intake modulated the expression of 1,819 genes. Between the orange juice and hesperidin consumption groups, 1,582 regulated genes were in common. Many of these genes are implicated in chemotaxis, adhesion, infiltration and lipid transport, which is suggestive of lower recruitment and infiltration of circulating cells to vascular wall and lower lipid accumulation. Conclusions This study shows that regular consumption of orange juice for 4 weeks alters leukocyte gene expression to an anti-inflammatory and anti-atherogenic profile, and hesperidin displays a relevant role in the genomic effect of this beverage. Trial Registration ClinicalTrials.gov NCT 00983086
Bisphenol-A ( BPA ) Alters Plasma Thyroid Hormones and Sex Steroids in Female Pakistani Major Carp ( Catla catla ; Cyprinidae )

Received: Revised: Accepted: Published online: October 10, 2016 March 12, 2017 March 14, 2017 May 09, 2017 In teleosts, steroid synthesis is mainly controlled by hypothalamus-pituitary-gonadal (HPG) axis. A number of compounds released into aquatic environment that have potential to interfere with fish endocrine system. These endocrine disturbing chemicals (EDCs) can disturb piscine endocrine system at every level by interference with HPG axis. Bisphenol-A (BPA) is an estrogenic endocrine disrupting chemical used in production of polycarbonate plastic and epoxy resins. The present study was aimed to investigate the effects of BPA on level of steroid and thyroid hormones in a fresh water cyprinid, Catla catla. Virgin female C. catla, two years of age, were exposed to graded concentration of BPA (10,100 and 1000μg/l) for 14 days, after stipulated time fish were bled and hormone titers were estimated. Plasma level of estradiol significantly increased in response to 100 and 1000μg/l BPA exposure. A significant decrease in plasma testosterone, triiodothyroxin (T3), thyroxin (T4) was recorded after 14 days BPA exposure. Plasma follicle-stimulating hormone (FSH) levels showed significant increase only at 10μg/l BPA exposure. Significant increase in plasma luteinizing hormone (LH) was observed in fish exposed to 1000μg/l of BPA. Change in plasma sex hormone and gonadotropin levels may cause subsequent reproductive dysfunction by interfering with the feedback regulatory mechanisms of the HPG-axis.
Raw Material Equivalents: The Challenges of Accounting for Sustainability in a Globalized World

The indicator domestic material consumption (domestic extraction + imports – exports) is widely used to track the scale, composition, and dynamics of material use. As production increasingly occurs at a spatial distance from the demand it ultimately satisfies, new accounting challenges arise that this indicator may not be able to meet. In response, indicators in raw material equivalents (RME) have been developed to account for material use, no matter where it occurs, associated with final demand. RME indicators are most commonly calculated based on monetary input-output tables with material extensions. The resulting indicators, which are rapidly gaining scientific and political importance, must be interpreted as stemming from a mixed monetary and physical accounting approach. How such an approach differs from a physical accounting approach is shown in this article using an input-output model with a material extension. Neither the physical nor the mixed monetary and physical approach is found to generate results which are incorrect. Instead, the results must be interpreted in light of the assumptions entailed in the approach on which they are based. In making possibilities and limits of interpretation in both cases transparent, RME indicators can more readily be discussed and used by sustainability scientists and practitioners.
The influence of snow sublimation and meltwater evaporation on δ D of water vapor in the atmospheric boundary layer of central Europe

Abstract. Post-depositional fractionation of stable water isotopes due to fractionating surface evaporation introduces uncertainty to various isotope applications such as the reconstruction of paleotemperatures, paleoaltimetry, and the investigation of groundwater formation. In this study, we investigate isotope fractionation at snow-covered moisture sources by combining 17 months of observations of isotope concentration ratios [HD16O] ∕ [H216O] in low-level water vapor in central Europe with a new Lagrangian isotope model. The isotope model is capable of reproducing variations of the observed isotope ratios with a correlation coefficient R of 0.82. Observations from 38 days were associated with cold snaps and moisture uptake in snow-covered regions. Deviations between modeled and measured isotope ratios during the cold snaps were related to differences in skin temperatures (Tskin). Analysis of Tskin provided by the Global Data Assimilation System (GDAS) of the NCEP implies the existence of two regimes of Tskin with different types of isotope fractionation during evaporation: a cold regime with Tskin
Lower fasting blood glucose in neurofibromatosis type 1

Studies indicate a lower occurrence of diabetes mellitus (DM) in patients with neurofibromatosis type 1 (NF1). Fasting blood glucose (FBG) level is the main criterion used to diagnose DM and glucose intolerance. Therefore, this study compared FBG level between adults with NF1 and non-NF1 controls. We selected clinical records of 57 out of 701 individuals attending the Neurofibromatosis Outpatient Reference Center of the Clinics Hospital of the Federal University of Minas Gerais in Brazil. The selected patients with NF1 were matched to non-NF1 controls selected from the Brazilian Longitudinal Study of Adult Health according to sex, age (range, 35–74 years) and BMI at a ratio of 1:3. In both groups, individuals with DM were excluded. Median FBG level in the NF1 group (86 mg/dl (range, 56–127 mg/dl)) was lower than that in the non-NF1 control group (102 mg/dl (range, 85–146 mg/dl)) (P<0.001). Prevalence of FBG level ≥100 mg/dl in the NF1 group (16%) was lower than that in the non-NF1 control group (63%) (P<0.05). The chance of a high FBG level was 89% lower in the NF1 group (odds ratio, 0.112; 95% CI, 0.067–0.188) (P<0.05). In conclusion, adults with NF1 showed a lower FBG level and a lower prevalence of high FBG level compared with non-NF1 controls.
Two-dimensional ferroelectricity and switchable spin-textures in ultra-thin elemental Te multilayers

New ferroelectric materials with satisfactory performance at the nanoscale are critical for the ever-developing microelectronics industry. Here, we report two-dimensional (2D) ferroelectricity in elemental tellurium multilayers, which exhibit spontaneous in-plane polarization due to the interlayer interaction between lone pairs. The magnitude of the polarization reaches about 1.02 × 10−10 C m−1 per layer, which can be detected by current experimental technology as recently done for the 2D FE compound SnTe. The spontaneous ferroelectric polarization can be preserved for the bilayer Te film even above room temperature. Also, we show that due to the strong spin–orbit coupling of Te, there appear nontrivial valley-dependent spin-textures for the hole carriers, and the textures are coupled with the direction of FE polarization, which is tunable by an external electric field. Our findings not only introduce the concept of ferroelectricity in elemental systems, but also broaden the family of the 2D ferroelectric materials and offer a promising platform for novel electronic and spintronic applications.
An Assessment of Carbon Storage in China’s Arboreal Forests

In the years 2009–2013, China carried out its eighth national survey of forest resources. Based on the survey data, this paper used a biomass conversion function method to evaluate the carbon stores and carbon density of China’s arboreal forests. The results showed that: (1) By age group, the largest portion of carbon stores in China’s arboreal forests are in middle-aged forests. Over-mature forests have the least carbon storage; (2) By origin, natural forests of all age groups have higher carbon storage and carbon density than man-made forest plantations. The carbon density of natural forests and forest plantations increases gradually with the age of the trees; (3) By type (dominant tree species), the 18 most abundant types of arboreal forest in China account for approximately 94% of the nation’s total arboreal forest biomass and carbon storage. Among these, broadleaf mixed and Quercus spp. form the two largest portions. Taxus spp. forests, while comprising a very small portion of China’s forested area, have very high carbon density; (4) By region, the overall arboreal forest carbon storage is highest in the southwest part of China, and lowest in the northwest. However, because of differences in land use and forest coverage ratios, regions with arboreal forests of high carbon density are not necessarily the same regions that have high overall carbon storage; (5) By province, Heilongjiang, Yunnan, Tibet, Sichuan, Inner Mongolia, and Jilin have rather high carbon storage. The arboreal forests in Tibet, Jilin, Xinjiang, Sichuan, Yunnan, and Hainan have a rather high carbon density. This paper’s evaluation of carbon storage in China’s arboreal forests is a valuable reference for interpreting the role and function of Chinese ecosystems in coping with global climate change.
Mangiferin Attenuate Sepsis-Induced Acute Kidney Injury via Antioxidant and Anti-Inflammatory Effects

Background: Acute kidney injury (AKI) is a frequent and serious complication of sepsis. A growing body of evidence now suggests that inflammatory reactions and tubular dysfunction induced by oxidative stress involved in the mechanisms of the disease. This study aimed to determine the role of anti-inflammatory and anti-oxidant activities of mangiferin (MA) in sepsis-induced AKI. Methods: We investigated the effects of MA on apoptosis of rat kidney proximal tubular cell (RPTC), together with renal function and morphological alterations of mice undergoing cecal-ligation and puncture (CLP). The levels of oxidative stress in kidney tissues were also determined. Moreover, we mainly focus on the effects of MA in regulating the production of NLRP3 and Nrf2 in the present study. Results: The exposure to LPS (5 Vg/ml) yielded a signiﬁcant increase of apoptosis in RPTC cells, which was largely inhibited by MA pretreatment. MA attenuates renal dysfunction and ameliorates the morphological changes in the septic mice induced by CLP. MA inhibits oxidative stress, decreases serum levels of IL-1F and IL-18, and prevents tubular epithelial cells apoptosis in kidneys of CLP mice model. Data in this study also suggest that MA promotes Nrf2 expression and suppresses renal NLRP3 inflammasome activation. Conclusion: In summary, MA protects against sepsis-induced AKI through NLRP3 inflammasome inhibition and Nrf2 up-regulation. Thus, the mangiferin could thus be a promising candidate for development of a multi-potent drug. i 2014 S. Karger AG, Basel
Conservative management versus endovascular or open surgery in the spectrum of type B aortic dissection.

Background Type B aortic dissection is a life-threatening acute aortic condition often with acute ischemic signs or symptoms. With initial management focusing on alleviating malperfusion and pain, and avoiding propagation of dissection or rupture both systolic blood and pulse pressure should be reduced initially by an aggressive medical approach. In the setting of persistent signs of complications endovascular strategies have replaced open surgery and led to a fourfold increase in early survival and better long-term outcomes. Methods An electronic health database search was performed on articles published between January 2006 and July 2017. Publications were included in this review if (I) the index aortic pathology was type B aortic (distal) dissection; (II) when medical management, open surgical replacement or thoracic endovascular aortic repair were among those options; (III) when at least one of all basic outcome criteria such as survival, spinal cord ischemia and cerebrovascular accident was reported; (IV) when ≥15 serial patients were included. A total of 62 studies were eligible and analysed. Results Our manuscript has summarized data collected over 12 years on management specific outcomes in the setting of distal aortic dissection and provides an up-to-date interpretation of the published evidence. For complicated cases, treated acutely, the 30-day or in-hospital mortality was 7.3% when managed by endovascular means, whereas the pooled rate for 30-day or in-hospital mortality was 19.0% when subjected to open repair. For acute uncomplicated type B dissection usually treated with blood pressure lowering medications, the pooled 30-day or in-hospital mortality rate was 2.4%. Survival rates at 5 years averaged at 60% (40% mortality). Freedom from any aortic event ranged from 34.0% to 83.9%, underlining an inherent risk of progression and late complications. For chronic complicated type B dissection, the rates of stroke, paraplegia and operative mortality following endovascular repair ranged from 5% to 13%, 2% to 13% and 2 to 13%, respectively, while 5-year survival rates after open repair ranged from 60% to 90%. In chronic uncomplicated type B dissection almost 90% of patients survive initial hospitalization and were subjected to medical management with a 5-year survival of 50-80%. However, up to 20-55% of medically treated patients develop aneurysmal degeneration after 5 years with an unknown risk of rupture. Conclusions Currently, the less invasive strategy of endovascular repair (as compared to open surgery) provides improved 30-day or in-hospital survival in the setting of complicated acute type B aortic dissection and may seek broad application. Open surgical aortic reconstruction should be left to experienced aortic centres if endovascular management is not an option.
The Combination of a Low-Dose Chemotherapeutic Agent, 5-Fluorouracil, and an Adenoviral Tumor Vaccine Has a Synergistic Benefit on Survival in a Tumor Model System

Standard cancer therapies, particularly those involving chemotherapy, are in need of modifications that both reduce short-term and long-term side effects as well as improve the overall survival of cancer patients. Here we show that combining low-dose chemotherapy with a therapeutic vaccination using an adenovirus encoding a model tumor-associated antigen, ovalbumin (Ad5-OVA), had a synergistic impact on survival in tumor-challenged mice. Mice that received the combinatorial treatment of Ad5-OVA plus low-dose 5-fluorouracil (5-FU) had a 95% survival rate compared to 7% and 30% survival rates for Ad5-OVA alone and 5-FU alone respectively. The presence of 5-FU enhanced the levels of OVA-specific CD8+ T lymphocytes in the spleens and draining lymph nodes of Ad5-OVA-treated mice, a phenomenon that was dependent on the mice having been tumor-challenged. Thus 5-FU may have enhanced survival of Ad5-OVA-treated mice by enhancing the tumor-specific immune response combined with eliminating tumor bulk. We also investigated the possibility that the observed therapeutic benefit may have been derived from the capacity of 5-FU to deplete MDSC populations. The findings presented here promote the concept of combining adenoviral cancer vaccines with low-dose chemotherapy.
Alterations of the viroid regions that interact with the host defense genes attenuate viroid infection in host plant

ABSTRACT Understanding in intimate details how the viroid interaction with host's defense genes is a cornerstone for developing viroid resistant plants. In this present study, small RNAs (sRNA) derived from Potato spindle tuber viroid (PSTVd) were studied in silico in order to detect any interactions with the serine threonine kinase receptor, a transmembrane protein that plays a role in disease resistance in plants. Using molecular biology techniques, it was determined that PSTVd infection negatively affects at least three serine threonine kinase receptors as well as with three other genes that are known to be involved in the overall development of the tomato plants. The transient expression of these putative PSTVd-sRNAs, using the microRNA sequence as a backbone, in tomato plants induced phenotypes similar to viroid infection. Mutants created by altering the sequence of PSTVd in these regions failed to infect the tomato plant. The data presented here illustrates the importance of these regions in viroid survival, and suggests a possible avenue of exploration for the development of viroid resistant plants.
Gamification for Self-Tracking: From World of Warcraft to the Design of Personal Informatics Systems

World of Warcraft (WoW) may be a source of inspiration to enrich the Personal Informatics systems user's experience and, at the same time, improve gamification design. Through the findings of a four-year reflexive ethnography in WoW, I outline how its game design elements support players in making sense of their own data, emphasizing how "game numbers" are turned into meanings. On the basis of the study results, I propose a series of design considerations to be used in the design of self-tracking systems, which recommend to embody data into digital entities, provide different analytical tools depending on the users' expertise through a flexible model, and foster the formation of "communities of practice" in order to support learning processes.
Boolean functions on high-dimensional expanders

We initiate the study of Boolean function analysis on high-dimensional expanders. We give a random-walk based definition of high dimensional expansion, which coincides with the earlier definition in terms of two-sided link expanders. Using this definition, we describe an analogue of the Fourier expansion and the Fourier levels of the Boolean hypercube for simplicial complexes. Our analogue is a decomposition into approximate eigenspaces of random walks associated with the simplicial complexes. We then use this decomposition to extend the Friedgut-Kalai-Naor theorem to high-dimensional expanders. Our results demonstrate that a high-dimensional expander can sometimes serve as a sparse model for the Boolean slice or hypercube, and quite possibly additional results from Boolean function analysis can be carried over to this sparse model. Therefore, this model can be viewed as a derandomization of the Boolean slice, containing only $|X(k-1)|=O(n)$ points in contrast to $\binom{n}{k}$ points in the $(k)$-slice (which consists of all $n$-bit strings with exactly $k$ ones). Our random-walk definition and the decomposition has the additional advantage that they extend to the more general setting of posets, which include both high-dimensional expanders and the Grassmann poset, which appears in recent works on the unique games conjecture.