Miracle-dz/UniFAR-FTUs huggingface dataset:
Impacts of Climate Change on Domestic Tourism in the UK: A Panel Data Estimation

Climate change is likely to have a significant impact on a number of key economic sectors, including tourism. The authors employ panel data techniques on regional tourist and climatic data in the UK to estimate the influence of temperature, precipitation and sunny conditions on domestic tourism. Significant impacts are found, including lagged relationships. The model is then used to estimate the impact of the hot weather of summer 2003 on domestic tourism in the UK, finding a positive impact on revenues ranging between £14.79 million and £30.32 million.
A frequent roundworm Baylisascaris transfuga in overpopulated brown bears (Ursus arctos) in Slovakia: a problem worthy of attention

The genus Baylisascaris (order Ascaridida) includes numerous relatively host-specific nematodes, which are common in intestines of wild mammals. Some of them may have impact on veterinary and public health, as their larvae have the potential to cause visceral, ocular, and/or neural larva migrans in a wide range of mammals, birds, and humans. Baylisascaris transfuga is a parasite occurring in a range of bear species throughout the world. We present the current data on B. transfuga occurrence in brown bears from a relatively restricted territory of the Poľana Protected Landscape Area in Central Slovakia, obtained by traditional methods (faecal examination, morphology). Species affiliation was confirmed by employing molecular markers generating nuclear 28S and mitochondrial cox1 sequences in adult worms. Based on 17 examined samples (15 excrements and two intestines of young bear females), the occurrence of B. transfuga in the surveyed area was assessed as 52.9%. Both bear females were infected with adult and juvenile worms. Due to the high density of bears in the locality, the high infection rate with ascarids, and the huge number of eggs produced by the parasites, it is apparent that the respective environment, including the inhabited areas, might be markedly contaminated by Baylisascaris eggs. The ability of B. transfuga to serve as a zoonotic agent has not been unambiguously proved; however, this attribute should be considered and subjected to further research.
Beyond Organic and Fair Trade? An Analysis of Ecolabel Preferences in the United States

The success of alternative food initiatives indicates increasing interest in changing the way food is produced, processed, and sold. Ecolabels such as organic and Fair Trade have entered the mainstream marketplace, and other voluntary identifiers on products are emerging to address criteria not included in these successful initiatives. Little is known about consumer interests in these criteria, however. To anticipate the direction of food-system changes, as well as assist food producers to meet consumer demands, we conducted a national mail survey to assess preferences for criteria that go “beyond” (or could complement) organic and Fair Trade. We utilized a forced-choice paired-comparisons question format to rank five possibilities (humane, local, living wage, small-scale, U.S. grown) that might feasibly be implemented by food producers. Local was the most popular choice, although humane also received a high level of support. Multilevel logistic regression indicated that local was preferred by rural residents, and that humane was preferred by frequent organic consumers and high-income households. Survey respondents also chose product labels more frequently than other potential sources of information about their food. Preferences for local and humane ecolabel criteria should be placed in perspective, as consumers expressed much higher levels of interest in the more individualized concerns of safety and nutrition. The results suggest, however, that consumers are interested in a food system that addresses broader political and ethical values, which has implications for production, marketing, and movement building for sustainable food systems.
Recombinant Newcastle Disease Virus Expressing a Foreign Viral Antigen Is Attenuated and Highly Immunogenic in Primates

ABSTRACT Paramyxoviruses such as human parainfluenza viruses that bear inserts encoding protective antigens of heterologous viruses can induce an effective immunity against the heterologous viruses in experimental animals. However, vectors based on common human pathogens would be expected to be restricted in replication in the adult human population due to high seroprevalence, an effect that would reduce vector immunogenicity. To address this issue, we evaluated Newcastle disease virus (NDV), an avian paramyxovirus that is serotypically distinct from common human pathogens, as a vaccine vector. Two strains were evaluated: the attenuated vaccine strain LaSota (NDV-LS) that replicates mostly in the chicken respiratory tract and the Beaudette C (NDV-BC) strain of intermediate virulence that produces mild systemic infection in chickens. A recombinant version of each virus was modified by the insertion, between the P and M genes, of a gene cassette encoding the human parainfluenza virus type 3 (HPIV3) hemagglutinin-neuraminidase (HN) protein, a test antigen with considerable historic data. The recombinant viruses were administered to African green monkeys (NDV-BC and NDV-LS) and rhesus monkeys (NDV-BC only) by combined intranasal and intratracheal routes at a dose of 106.5 PFU per site, with a second equivalent dose administered 28 days later. Little or no virus shedding was detected in nose-throat swabs or tracheal lavages following immunization with either strain. In a separate experiment, direct examination of lung tissue confirmed a highly attenuated, restricted pattern of replication by parental NDV-BC. The serum antibody response to the foreign HN protein induced by the first immunization with either NDV vector was somewhat less than that observed following a wild-type HPIV3 infection; however, the titer following the second dose exceeded that observed with HPIV3 infection, even though HPIV3 replicates much more efficiently than NDV in these animals. NDV appears to be a promising vector for the development of vaccines for humans; one application would be in controlling localized outbreaks of emerging pathogens.
The Influence of Human Resource Management Practices on Employee Voluntary Turnover Rates in the Canadian Non Governmental Sector

The authors tested the influence of thirteen human resource management practices on voluntary turnover rates the following year while controlling for workplace size, the presence of a separate human resources management unit, union density, industry, and region. Analysis of data from 4,160 workplaces representative of Canadian industries found that employer-provided training is associated with higher turnover, whereas internal labor markets and formal dispute resolution procedures are associated with lower turnover. The findings are consistent with predictions that some human resource management practices reduce workers' desire to leave and that training may actually make their leaving easier.
Survival of B Lineage Leukemic Cells: Signals from the Bone Marrow Microenvironment

Stromal cells are an essential component of the bone marrow microenvironment that regulate development of immature hematopoietic progenitor cells. Through production of soluble cytokines, and signaling through adhesion molecule interactions, stromal cells impact survival, proliferation, and differentiation of hematopoietic progenitor cells. Similarities between normal pro-B and pre-B cells and B lineage acute lymphoblastic leukemic (ALL) progenitors have been well characterized which provide a model for investigation of the mechanisms by which ALL cells respond to bone marrow microenvironment signals. In addition to providing survival signals to B lineage ALL during initiation of disease, the bone marrow has long been recognized as a "sanctuary site" for leukemic cells during traditional chemotherapy. In the current review, mechanisms by which stromal cells contribute to leukemic cell survival, and the potential impact on treatment efficacy, are discussed. A growing appreciation of the significance of the bone marrow microenvironment in the progression of ALL, and further investigation of the signaling between leukemic progenitors and stromal cells, may contribute to novel treatment strategies aimed at enhancing sensitivity of ALL cells to currently available chemotherapeutic agents.
First voluntary disclosure: is it less opportunistic?

The objective of voluntary disclosure regulation is to mitigate information asymmetry between the management and outside users. However, prior studies on voluntary disclosures provide mixed evidences on managers’ incentives. Using a setting of voluntary non-generally accepted accounting principles earnings per share (GAAP EPS) reporting, this study attempts to examine whether the first non-GAAP EPS reporting is less dominated by opportunistic incentives. Consistent with the predictions of this research, it reveals that the duration to the first adjusted EPS disclosure is not more sensitive to negative transitory items, and moreover investors’ perception on the first non-GAAP EPS is more positive compared to subsequent ones. The less opportunistic behaviour on the first disclosure can be well explained by the management’s awareness of intensified monitoring by outside stakeholders.
Financial Exclusion in the European Union: Addressing Difficulties in Accessing Finance within the Current Integration Framework

This article explores the role of the European Union (EU) in addressing financial exclusion. From a multidisciplinary point of view, we focus on the EU's approach, emphasising the peculiarities derived from the European integration process. In spite of the high level of financial inclusion in the EU in comparison with other regions, there is a substantial percentage of people and small and medium enterprises (SMEs) facing difficulty in accessing financial services; the population at risk of financial exclusion is growing due to increasing unemployment and cuts in social assistance services. This article, after contextualising the problem of financial exclusion in the global context, presents a revision of European initiatives associated with this problem, notably the reform of the financial system and the increasing integration of its internal market. We discuss the extent to which this legislation and related policy recommendations are effective, particularly considering the current framework of economic.
Client Perceptions of the Value of Microinsurance: Evidence from Southern Ghana

The uptake of microinsurance in developing countries falls short of projections, which has recently made stakeholders focus on client value. This article investigates when and why clients of a micro life insurance product in Ghana perceive value, using data from focus group discussions. We show that value depends not only on costs and monetary benefits but also on the service quality, emotions and social benefits that are associated with the product. Perceptions of high or low value can be explained by how expectations compare with actual experiences with the insurance as well as the specific client context. Peers strongly influence each other in their value perceptions. Copyright © 2015 John Wiley & Sons, Ltd.
Proteomic Analysis Reveals a Role for Bcl2-associated Athanogene 3 and Major Vault Protein in Resistance to Apoptosis in Senescent Cells by Regulating ERK1/2 Activation*

Senescence is a prominent solid tumor response to therapy in which cells avoid apoptosis and instead enter into prolonged cell cycle arrest. We applied a quantitative proteomics screen to identify signals that lead to therapy-induced senescence and discovered that Bcl2-associated athanogene 3 (Bag3) is up-regulated after adriamycin treatment in MCF7 cells. Bag3 is a member of the BAG family of co-chaperones that interacts with Hsp70. Bag3 also regulates major cell-signaling pathways. Mass spectrometry analysis of the Bag3 Complex revealed a novel interaction between Bag3 and Major Vault Protein (MVP). Silencing of Bag3 or MVP shifts the cellular response to adriamycin to favor apoptosis. We demonstrate that Bag3 and MVP contribute to apoptosis resistance in therapy-induced senescence by increasing the level of activation of extracellular signal-regulated kinase1/2 (ERK1/2). Silencing of either Bag3 or MVP decreased ERK1/2 activation and promoted apoptosis in adriamycin-treated cells. An increase in nuclear accumulation of MVP is observed during therapy-induced senescence and the shift in MVP subcellular localization is Bag3-dependent. We propose a model in which Bag3 binds to MVP and facilitates MVP accumulation in the nucleus, which sustains ERK1/2 activation. We confirmed that silencing of Bag3 or MVP shifts the response toward apoptosis and regulates ERK1/2 activation in a panel of diverse breast cancer cell lines. This study highlights Bag3-MVP as an important complex that regulates a potent prosurvival signaling pathway and contributes to chemotherapy resistance in breast cancer.
From focal sepsis to periodontal medicine: a century of exploring the role of the oral microbiome in systemic disease

The oral microbiome is established within a few minutes after birth and consists of stable multi‐species communities that engage in a dynamic equilibrium with the host immune system. Dental caries, endodontic infections and periodontal diseases are bacterially driven diseases that are caused by dysbiotic microbiomes. Over a century ago, the focal infection theory implicated these infections in the aetiology of several systemic diseases, ranging from arthritis to neurodegenerative diseases. However, a lack of concrete evidence, combined with the urgency with which clinicians embraced this approach without regard for appropriate case selection, led to its demise within 30 years. In the last decade of the 20th century, the concept of periodontal medicine was introduced to explain the correlations that were being observed between periodontitis and cardiovascular disease, rheumatoid arthritis, Alzheimer's disease, pulmonary disease, pre‐term delivery of low birth weight infants and metabolic disease. It was proposed that periodontal pathobionts played a causal role in the initiating or exacerbating certain diseases either by direct invasion or by stimulating a florid immune‐inflammatory response that extended into the systemic circulation. This review will examine the strength of current evidence in establishing a causal link between oral pathobionts and systemic disease.
Stem cell transplant: An experience from eastern India

Abstract Background: Hematopoietic stem cell transplant using human leukocyte antigen (HLA)-matched sibling or unrelated bone marrow, or related or unrelated cord blood has been performed successfully to treat patients with different types of hematological malignancies, genetic disorders and hereditary immune deficiencies. Since 1983, stem cell transplantation has been carried out in different institutes of India. But, till then, no transplantation was performed in eastern India. Materials and Methods: Our present study is reporting for the first time stem cell transplantation in eastern India. From August 2000 to June 2011 (with a 3-year gap for up-gradation), we have performed a total of 22 transplants. Thirteen patients (M:F:9:4) with indications of aplastic anemia, thalassaemia, acute myeloid leukemia and chronic myeloid leukemia underwent allogenic transplant, whereas autologous transplant was performed for nine patients (M:F:2:1) of multiple myeloma, Hodgkin′s and non-Hodgkin′s lymphoma and neuroblastoma. The median age of the patients was 19.6 years, with a range of 5 years 8 months to 52 years. Fourteen patients received myeloablative conditioning regime whereas eight patients received immunosuppressive and less myeloablative protocol. Sources of stem cells in case of allogenic transplant are bone marrow and related or unrelated umbilical cord blood and in case of autologous transplant, these are peripheral blood stem cells or self-bone marrow. Standard prophylactic medication was followed prior to transplants. Results: A disease-free survival of 68.18% and overall survival of 86.3% were seen at the median follow-up period of 4.6 years. Common post-transplant complications were mucositis, infection, venoocclusive disease, graft versus host disease, hemorrhagic cystitis, etc. Conclusion: The use of cord blood as a source of stem cells has been proved inferior as compared with the bone marrow stem cell source in cases of thalassaemia in our institute and thus is not recommended for thalassaemia. But, it has been proved to be a very useful and effective stem cell source (both related and unrelated cord blood) in cases of aplastic anemia and other immunological disorders.
Affordable Rental Housing: Lost, Stolen and Strayed

This paper contributes to an exploration of the potential causes (as distinct from existence) of social and spatial polarisation. It focuses on the changing provision of low-rent housing in a spatial context, and hence on the role that the private rental market plays in the residential choices available to lower income households. The paper applies multinomial logit estimation to panel data to determine the factors that affect the probability that an existing rental dwelling remains at the same real rent value over the decade from 1991 to 2001, filters down or up or exits from the private rental market. It tests the hypothesis that the outcome is affected by neighbourhood characteristics.
Secondary equity offerings as a leading indicator of market performance

Secondary Equity Offerings as a Leading Indicator of Market Performance examines the perception of an imminent market downturn as a motive behind new dilutive stock issuances. Market conditions, represented by the value of the TSX composite index, are found to have a weak , yet significant relationship with the total gross proceeds of secondary offerings. The paper interprets this relationship as evidence that an influx of seasoned equity offerings is a leading indicator of a market downturn. The paper suggests that this is a result of opportunistic managers cashing in on favourable market conditions in order to insulate their capital holdings while the opportunity is still available. The paper observes a trend in which the leading secondary issuances tend to occur in two distinct peaks. The “dual peak” effect is believed to be a product of herding by managers due to relative risk sensitivity.
Theory of mind deficits for processing counterfactual information in persons with chronic schizophrenia

Background Interpersonal communication problems are common among persons with schizophrenia and may be linked, in part, to deficits in theory of mind (ToM), the ability to accurately perceive the attitudes, beliefs and intentions of others. Particular difficulties might be expected in the processing of counterfactual information such as sarcasm or lies. Method The present study included 50 schizophrenia or schizo-affective out-patients and 44 demographically comparable healthy adults who were administered Part III of The Awareness of Social Inference Test (TASIT; a measure assessing comprehension of sarcasm versus lies) as well as measures of positive and negative symptoms and community functioning. Results TASIT data were analyzed using a 2 (group: patients versus healthy adults)×2 (condition: sarcasm versus lie) repeated-measures ANOVA. The results show significant effects for group, condition, and the group×condition interaction. Compared to controls, patients performed significantly worse on sarcasm but not lie scenes. Within-group contrasts showed that patients performed significantly worse on sarcasm versus lie scenes; controls performed comparably on both. In patients, performance on TASIT showed a significant correlation with positive, but not negative, symptoms. The group and interaction effects remained significant when rerun with a subset of patients with low-level positive symptoms. The findings for a relationship between TASIT performance and community functioning were essentially negative. Conclusions The findings replicate a prior demonstration of difficulty in the comprehension of sarcasm using a different test, but are not consistent with previous studies showing global ToM deficits in schizophrenia.
The Direct and Indirect Effects of Organizational Justice on the Human Factor through Mutual Commitment in Ghana and India: A Comparative Analysis

This study compares the influence of perceived procedural justice, interactional justice, and mutual commitment on the human factor in Ghana and India. The study further compares how mutual commitment mediates the relationship between procedural and interactional justice, and the human factor in the two countries. The findings indicate that the influence of both procedural and interactional justices on mutual commitment in Ghana and India are similar. However, the influence of procedural and interactional justices on the human factor, and the impact of mutual commitment on the human factor in Ghana and India are significantly different. While mutual commitment mediates the relationship between procedural and interactional justice in the two countries, the findings from Ghana is different from that from India. We discuss the implications of our findings.
Settled Tourists: Second Homes as a Part of Tourist Life Stories

In a society of mobile life‐styles, tourism has been fundamentally connected to the idea of being on the move without any firm attachment to any one place. However, it seems that being a tourist may often involve seeking a close relationship with one specific place or region, and wanting to “go steady” with that place or region. Thus, visitors may over time transcend their typical positions and make a place or a region their regular haunt or even “home”. The question posed in the paper is how do people become so attached to their tourist destinations that they eventually want to buy a second home or even move to such a location? The article also discusses the changes in second‐home traditions from simple summer cottages to fully‐equipped second homes and time‐shares situated in regions with which the owners have no social connections, but which have beautiful landscapes and other amenity values. Based on life‐story narratives of Finnish second‐home owners, who mainly got their first contact with the region as tourists, the results show that tourist experiences can be cumulative in a person's life course and place attachment and the sense of home develop in the course of many visits to same place.
Designing BPR support services for small firms

Notes that supporting small to medium‐sized enterprises (SMEs) in their process towards the adoption of business process re‐engineering (BPR) may be essential as the tools and methodologies of BPR were designed for larger companies. Presents a methodology for the design of support services, developed within the context of a European Union (EU) project. The methodology consists of four major steps. The first step consists of an analysis of users’ needs. Since BPR support needs are differentiated and often implicit, an “ad hoc” methodology was developed to make demand explicit and split the potential market into homogeneous segments. The second step identifies the proper services to meet the needs of SMEs. The third step explores current supply of services and the critical success factors of a BPR support centre. Finally, the fourth step defines guidelines for the design of both the support centre and the specific support services. The methodology was developed also on the basis of the case of the Lombard machinery industry. Finally, the paper discusses the transferability of the methodology to other regions and industries.