Miracle-dz/UniFAR-FTUs huggingface dataset:
The Capacity to Lead: Major Psychological Differences Between Leaders and Nonleaders

This study returns to the question that occupied “trait approach” scholars in the early days of leadership research: identification of the major capacities required for leadership. The conceptual and methodological progress that has been made in psychology since the trait approach enables us to formulate models and deal with variables that did not exist in the early days of leadership research. We argue that three types of psychological capacities are essential for leadership: (a) self confidence, expressed and measured by three variables—internal locus of control, low level of trait anxiety, and self-efficacy; (b) proactive orientation, expressed by optimism; and (c) capacities required for prosocial relationships, expressed by secure attachment styles. A series of questionnaires was administered to 402 soldiers from Infantry and Armored corps who were nearing the end of 3 months' basic training. A sociometric questionnaire examining the peers' and commanders' evaluations of the soldiers' leadership capacities was used to evaluate each soldier and to classify the soldiers di-chotomously as leaders and nonleaders. The findings reveal significant differences between leaders and nonleaders in all the variables that were defined as psychological capacities to lead. Leaders have more internal locus of control, a lower level of anxiety, higher self-efficacy, and more optimism, and they rank higher in the measure of secure attachment style. Anxiety, locus of control, and attachment style were found to be significant in the regression equation, but trait anxiety was found to be the most discriminant variable. The implications of the findings in the light of relevant psychological models are discussed.
DeepTransport: Prediction and Simulation of Human Mobility and Transportation Mode at a Citywide Level

Traffic congestion causes huge economic loss worldwide in every year due to wasted fuel, excessive air pollution, lost time, and reduced productivity. Understanding how humans move and select the transportation mode throughout a large-scale transportation network is vital for urban congestion prediction and transportation scheduling. In this study, we collect big and heterogeneous data (e.g., GPS records and transportation network data), and we build an intelligent system, namely DeepTransport, for simulating and predicting human mobility and transportation mode at a citywide level. The key component of DeepTransport is based on the deep learning architecture that that aims to understand human mobility and transportation patterns from big and heterogeneous data. Based on the learning model, given any time period, specific location of the city or people's observed movements, our system can automatically simulate or predict the persons' future movements and their transportation mode in the large-scale transportation network. Experimental results and validations demonstrate the efficiency and superior performance of our system, and suggest that human transportation mode may be predicted and simulated more easily than previously thought.
Molecular Characterization of Extended-Spectrum-β-Lactamase-Producing and Plasmid-Mediated AmpC β-Lactamase-Producing Escherichia coli Isolated from Stray Dogs in South Korea

ABSTRACT A total of 47 extended-spectrum-cephalosporin-resistant Escherichia coli strains isolated from stray dogs in 2006 and 2007 in the Republic of Korea were investigated using molecular methods. Extended-spectrum β-lactamase (ESBL) and AmpC β-lactamase phenotypes were identified in 12 and 23 E. coli isolates, respectively. All 12 ESBL-producing isolates carried blaCTX-M genes. The most common CTX-M types were CTX-M-14 (n = 5) and CTX-M-24 (n = 3). Isolates producing CTX-M-3, CTX-M-55, CTX-M-27, and CTX-M-65 were also identified. Twenty-one of 23 AmpC β-lactamase-producing isolates were found to carry blaCMY-2 genes. TEM-1 was associated with CTX-M and CMY-2 β-lactamases in 4 and 15 isolates, respectively. In addition to blaTEM-1, two isolates carried blaDHA-1, and one of them cocarried blaCMY-2. Both CTX-M and CMY-2 genes were located on large (40 to 170 kb) conjugative plasmids that contained the insertion sequence ISEcp1 upstream of the bla genes. Only in the case of CTX-M genes was there an IS903 sequence downstream of the gene. The spread of ESBLs and AmpC β-lactamases occurred via both horizontal gene transfer, accounting for much of the CTX-M gene dissemination, and clonal spread, accounting for CMY-2 gene dissemination. The horizontal dissemination of blaCTX-M and blaCMY-2 genes was mediated by IncF and IncI1-Iγ plasmids, respectively. The clonal spread of blaCMY-2 was driven mainly by E. coli strains of virulent phylogroup D lineage ST648. To our knowledge, this is the first report of blaDHA-1 in E. coli strains isolated from companion animals. This study also represents the first report of CMY-2 β-lactamase-producing E. coli isolates from dogs in the Republic of Korea.
Disruptive information system innovation: the case of internet computing

Abstract. Information system (IS) innovation can be defined as a novel organizational application of digital computer and information communication technologies (ICT). This paper discusses how modalities of applying ICT technologies in their form and scope exhibit radical breaks, which are introduced herein as ‘disruptive IS innovations’. This notion of disruptive IS innovation is developed by drawing upon and extending Swanson's (1994) theory of IS innovation as well as the concept of radical innovation. Disruptive innovations strongly influence the future trajectory of the adoption and use of ICT in organizational contexts and make the trajectory deviate from its expected course. In doing so, these disruptive innovations distinctly define what an IS is and how it is deployed in order to address current and future organizational and managerial prerogatives. Such changes are triggered breakthroughs in the capability of ICT that lead to the revision and expansion of associated cognitive models (frames) of computing. Disruptive IS innovations are those that lead to changes in the application of ICT that are both pervasive and radical. The pervasive nature implies that innovative activity spans all innovation subsets of the quad‐core model of IS innovation introduced herein. Innovation types include: IS use and development processes; application architecture and capability; and base technologies. Radical in nature, disruptive is innovations depart in significant ways from existing alternatives and lead to deviation from expected use and diffusion trajectory. This paper demonstrates the importance of a concept of disruptive IS innovation by investigating how changes triggered by internet computing (Lyytinen et al., 1998) meet the conditions of a disruptive IS innovation defined herein. The analysis also affirms both the pervasive and radical nature of internet computing and explains how internet computing has fundamentally transformed the application portfolio, development practices and IS services over time. The analysis demonstrates that, with the concept of disruptive IS innovation, we can fruitfully analyse ‘long’ waves of ICT evolution – an issue that has largely been overlooked in the IS community. On a theoretical plane, the paper advocates the view that we need to look beyond linear, unidirectional, and atomistic concepts of the diffusion of IS innovations where innovative activity takes places in a linear fashion by oscillating between small technological innovations and small organizational innovations. In contrast, IS innovation can exhibit fundamental discontinuity; we need to theoretically grasp such disruptive moments. The recent influx of innovation, spurred by internet‐based technology, offers one such moment.
Automated estimation of human emotion from EEG using statistical features and SVM

This paper presents an approach for automated estimation of human emotions from electroencephalogram data. The used features are principally the Hjorth parameters calculated for theta, alpha, beta and gamma bands taken from certain channels. The classification stage is support vector machine. Since the human emotions are modelled as combinations from physiological elements such as arousal, valence, dominance, liking, etc., these quantities are the classifier's outputs. The best achieved correct classification performance is about 80%.
The incidence of Pneumocystis jirovecii pneumonia is not higher in patients receiving dose-dense therapy with rituximab, cyclophosphamide, non-pegylated liposomal doxorubicin, vincristine, and prednisolone and adequate Pneumocystis jirovecii pneumonia prophylaxis

Pneumocystis jirovecii pneumonia (PCP) is a rare but serious complication observed in patients with lymphoma who are undergoing chemotherapy. Cotrimoxazole prophylaxis is used routinely for patients treated with agents leading to severe suppression of the cellular immune system, such as fludarabine and alemtuzumab, and minimizes the risk of developing PCP [1,2]. The risk of PCP is negligible for patients receiving standard CHOP or R-CHOP treatment (cyclophosphamide, adriamycin, vincristine, and prednisone, with or without rituximab, every 3 weeks). For this reason, prophylaxis with co-trimoxazole is not routinely administered to patients with lymphoma receiving 3-weekly CHOP schedules. However, this scenario seems to change dramatically with the administration of dose-dense biweekly CHOP or R-CHOP. Kamel et al. [3] recently reported a high incidence of PCP in patients receiving dose-dense R-CHOP 14 chemotherapy. The authors reported that among 47 patients with newly diagnosed aggressive B-cell nonHodgkin lymphoma (NHL) treated with R-CHOP 14, five (11% of patients) developed microbiologically proven PCP during therapy. This observation of an increased PCP risk with R-CHOP 14 had also been reported in other series [4–6], and, even if other series did not record an increased risk of PCP in intensified protocols [7], PCP came back into the limelight. In an elegant commentary, Tadmor et al. [8] underlined that the most likely cause for the increased risk of PCP in patients receiving dose-dense R-CHOP is the increased intensity of corticosteroid exposure, as well as the cumulative dose of the drug. Nevertheless, B-cell depletion induced by rituximab seems to play a major role, in particular when a dose-dense schedule of rituximab is employed. We consecutively enrolled 36 elderly patients (median age 75 years, range 65–89) with newly diagnosed aggressive B-cell NHL in a multicentric study evaluating the safety and effectiveness of a dose-dense chemotherapy regimen with rituximab, cyclophosphamide, non-pegylated liposomal doxorubicin (Myocet; Cephalon, Frazer, PA, USA), vincristine, and prednisolone (R-COMP 14). All patients gave written informed consent. The study was registered at EMEA (European Medicines Agency) with the EudraCT (European Union Drug Regulating Authorities Clinical Trials) number 2007-005613-19. All patients received dose-dense corticosteroid exposure. All of them received PCP
From the individual to the group: The enhancement of linguistic bias

The present contribution tested the general hypothesis that individual tendencies in the choice of terms at different levels of abstraction are enhanced when the same descriptions are formulated by a group. We compared the level of abstraction of individual and collective written judgements about applicants for a job position and found that the selection linguistic bias collectively expressed by hiring committees became more extreme in the direction established by initial individual judgements. Negative terms used to describe rejected applicants became more abstract, and those used to describe selected applicants became more concrete from individual to collective judgements. Conversely, positive terms employed to describe rejected applicants were more concrete in collective than individual judgements. Implications of these findings for the notion of language as a tool that enables coupling between group-shared knowledge and group goals activated by the task at hand are discussed. Copyright © 2011 John Wiley & Sons, Ltd.
Effect of magnetic field on the Yield and Chemical composition of Raphanus sativus L. seedlings

In order to study the effect of silver nanoparticles and magnetic field on Raphanus sativus. experiments were carried out with four treatments in 10 days. Treatments were including (CON) control, (MF) magnetic field with B=1.8 mT for 1h per day in 10 days, (SNPs) silver nanoparticles (50 ppm), (MF+SNPs) magnetic field plus silver nanoparticles. Results showed that silver nanoparticles (SNPs) had the highest yield and chemical composition while rate of yield and chemical composition in group of treated by magnetic field (MF) had the lowest. Experiment treatments had significantly effects on traits such as the plant height, fresh and dry weight, lenght of root and shoot. It seems that silver nanoparticles (50 ppm) had the best effect on Raphanus sativus growth, root and stem length, weight of stem fresh and dry, germination rate, seedling height, phenol, flavonoid, chlorophyll a and b content.
Cytokines Inhibit Sexual Behavior in Female Rats: I. Synergistic Effects of Tumor Necrosis Factor α and Interleukin-1

The secretion of cytokines such as tumor necrosis factor alpha (TNFalpha) and interleukin-1 (IL-1) during immune activation induces sickness behavior. We have previously demonstrated that administration of either lipopolysaccharide (LPS) or IL-1 suppresses sexual behavior in female, but not in male rats. In the present study we sought to determine some of the mechanisms that are involved in mediating the alterations of female sexual behavior during immune activation. We report that sexual motivation of estrous females was reduced by intracerebroventricular administration of either recombinant rat (rr)TNFalpha (7.5 microg/rat) or rrIL-1beta (100 ng/rat), whereas sexual receptivity was altered only by IL-1beta. A significant reduction of both sexual motivation and receptivity was also induced by the combined administration of subthreshold doses of TNFalpha (3 microg/rat) and IL-1beta (20 ng/rat). These findings indicate that TNFalpha and IL-1beta act synergistically to suppress sexual motivation and receptivity. Moreover, LPS (100 microg/kg, ip)-induced reduction of sexual motivation was antagonized by the combined administration of the TNFalpha synthesis blocker pentoxifylline (50 mg/kg, ip) and IL-1 receptor antagonist (10 mg/kg, ip), but not by the administration of each of these substances by itself. In contrast, LPS-induced reduction of sexual receptivity was completely prevented by pentoxifylline. These findings indicate that the effects of LPS on sexual motivation are mediated by the synergistic effects of TNFalpha and IL-1, but only TNFalpha is required for the effect of LPS on receptivity.
Effects of apomorphine on globus pallidus neurons in parkinsonian patients

Current hypotheses of basal ganglia dysfunction in Parkinson's disease (PD) propose that neuronal hypoactivity in the globus pallidus externus (GPe), and hyperactivity in the output nuclei and the external and internal portions of the globus pallidus internus (GPi, e and GPi, i, respectively), result in the cardinal symptoms of PD. To test this theory, the nonselective D1‐ and D2‐dopamine receptor agonist apomorphine (30–100 μg/kg SC) was administered to 14 levodoparesponsive PD patients who were off medication (“of” state) while recording neurons in GP. For 15 neurons that were continuously monitored, apomorphine was found to increase the firing rate of 3 neurons in GPe, and decrease the rate of 12 in GPi. The mean firing rates of many different neurons were determined before (n = 285) and at various intervals after (n = 184) the injection of the drug. The mean rates before apomorphine were as follows: GPe, 45 Hz (SD 15, n = 85); GPi, e, 67 Hz (SD 14, n = 125); and GPi, i, 85 Hz (SD 19, n = 75). At 25 to 35 minutes after APO, the rate of GPe neurons had increased to 72 Hz (SD 18, n = 7), the rate of GPi, e neurons had decreased to 39 Hz (SD 15, n = 15), and in GPi, i the rate decreased to 34 Hz (SD 22, n = 18). Eighty minutes after apomorphine administration, the mean firing rates returned to preadministration values. This study supports current models of basal ganglia dysfunction in PD and suggests that the thereapeutic effect of apomorphine results from a normalization of the imbalance of neuronal activity in the direct and indirect pathways.
Spatial cueing by social versus nonsocial directional signals

A cost-benefit analysis was used to investigate whether reflexive effects in a spatial cueing task are stronger when target location is cued by another person's gaze rather than arrows because the relative contribution of attentional shifts versus automatic priming is greater in the case of gaze cues. Across four experiments, nonpredictive arrows triggered rapid facilitatory, inhibition-less priming that peaked at 300-500ms SOA and then died away; across three experiments, nonpredictive gaze cues triggered facilitation-plus-costs at SOAs of 300-400ms or more, suggesting that gaze cues trigger stronger (and longer) attentional effects. At 200 ms SOA, gaze cues triggered facilitation-without-cost, consistent with the view that facilitatory effects accrue more rapidly due to earlier automatic priming, whereas costs are manifest slightly later, when attentional effects come online. There was some evidence that nonpredictive gaze cues trigger long-lasting congruency effects so long as observers maintain their preparedness to respond. Findings support the view that gaze is a unique symbolic directional cue.
Should social choice be based on binary comparisons

This paper argues that social choice from among more than two feasible alternatives should not be based on social choice from two‐alternative subsets. It considers in some detail the case where one alternative ties or beats every other alternative on the basis of simple majorities, and raises the question of whether such an alternative should be chosen. A condition of ‘stochastic unanimity’, introduced in this context, is shown to be incompatible with the simple majority rule when it can apply. This new condition plus a consideration of ties leads into a brief discussion of the use of individual expected utility in social choice theory.
XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.

Based on structural and evolutionary criteria, neuropeptide Y (NPY)b, peptide YY (PYY) and pancreatic polypetide (PP) are closely related polypeptides ([Larhammar, 1996a][1]). They are composed of 36 amino acids each and share considerable amino acid homology, amidated C-terminal ends, and the
Biased exon/intron distribution of cryptic and de novo 3′ splice sites

We compiled sequences of previously published aberrant 3′ splice sites (3′ss) that were generated by mutations in human disease genes. Cryptic 3′ss, defined here as those resulting from a mutation of the 3′YAG consensus, were more frequent in exons than in introns. They clustered in ∼20 nt region adjacent to authentic 3′ss, suggesting that their under-representation in introns is due to a depletion of AG dinucleotides in the polypyrimidine tract (PPT). In contrast, most aberrant 3′ss that were induced by mutations outside the 3′YAG consensus (designated ‘de novo’) were in introns. The activation of intronic de novo 3′ss was largely due to AG-creating mutations in the PPT. In contrast, exonic de novo 3′ss were more often induced by mutations improving the PPT, branchpoint sequence (BPS) or distant auxiliary signals, rather than by direct AG creation. The Shapiro–Senapathy matrix scores had a good prognostic value for cryptic, but not de novo 3′ss. Finally, AG-creating mutations in the PPT that produced aberrant 3′ss upstream of the predicted BPS in vivo shared a similar ‘BPS-new AG’ distance. Reduction of this distance and/or the strength of the new AG PPT in splicing reporter pre-mRNAs improved utilization of authentic 3′ss, suggesting that AG-creating mutations that are located closer to the BPS and are preceded by weaker PPT may result in less severe splicing defects.
Quantitative HBsAg levels do not identify hepatic fibrosis in HBeAg-negative chronic hepatitis B patients

Background/Aims: Quantitative serum hepatitis B surface antigen (qHBsAg) has been evaluated in limited patient groups as a marker of histological fibrosis. The accurate identification of inactive chronic hepatitis B virus (HBV) carriers from those with active carriers is difficult because of wide and frequent HBV DNA fluctuations. We aimed to assess the utility of qHBsAg in distinguishing histologically significant fibrosis in untreated HBeAg-negative chronic HBV patients. Patients and Methods: qHBsAg levels were measured at baseline as single-point quantification and correlated with virologic and biochemical profiles of consecutive carriers (median, 29; range, 12-110 months). HBeAg-negative patients (n = 75) with HBV DNA <2000 (n = 5), 2000-20,000 (n = 16) and >20,000 IU/mL (n = 54) were included and all had liver biopsy. A qHBsAg cutoff point of 1000 IU/mL was assessed to demonstrate whether it better delineated patients with non-significant histology (F0-1, inflammatory grade A0-1). Results: Mean age of the patients was 39.4 ± 11.4 years and 58 (77.3%) were male. Patients with qHBsAg levels >1000 IU/mL were more likely to be males (84.5%, P = 0.006) or with elevated AST (68.4%, P = 0.0002) and ALT levels (72.4%, P < 0.0001), higher HBV DNA (log10 6.4 ± 1.4, P < 0.0001) and those with F2-4 fibrosis (48.3%, P = 0.028). Serum log10 qHBsAg were significantly lower in patients with HBV DNA <2000 (2.80 ± 1.47) and HBV DNA 2000-20,000 (2.71 ± 0.83) vs. >20,000 IU/mL (3.89 ± 0.61, P < 0.0001). Overall, qHBsAg were not different in patients with F0-1 (3.44 ± 0.91) and F2-4 fibrosis (3.74 ± 0.85, P = 0.161). Serum qHBsAg were higher in patients with significant (A2-3) inflammation (3.85 ± 0.72) compared to A0-1 (3.38 ± 0.95; P = 0.018). Serum qHBsAg demonstrated poor accuracy (AUROC, 0.61, P = 0.111) in identification of F2-4 fibrosis. Conclusion: Serum qHBsAg levels do not help differentiate between those with HBV DNA <2000 or 2000 – 20,000 IU/mL or distinguish patients with significant fibrosis. Moreover, more than half of the patients with non-significant fibrosis have a qHBsAg level greater than 1000 IU/mL.
Rational deprescribing in the elderly.

BACKGROUND Polypharmacy, defined as being prescribed 5 or more medications, has been shown to be associated with a decline in mental and physical functioning in elderly patients. Despite this, elderly patients are currently being prescribed a median of 7 medications, which often causes more harm than benefit, and emphasizes the importance of deprescribing. METHODS Five classes of potentially inappropriate medications for the elderly population, especially for the aging brain, are discussed, including anticholinergics, benzodiazepines, antipsychotics, opioids, and proton pump inhibitors. Recommendations regarding these medications were collected from the 2015 Beer's Criteria, the Screening Tool of Older Person's Prescriptions (STOPP) criteria, the Screening Tool to Alert doctors to the Right Treatment (START) criteria, and the Fit fOR The Aged (FORTA) list. The PubMed database was also searched for the most recent evidence regarding prescription patterns, adverse effects, and recommendations regarding discontinuation of these medications in older adults. RESULTS Anticholinergics, benzodiazepines, antipsychotics, and opioids were all found to have significant adverse effects in the elderly population. All of the discussed medication classes have been shown to be successfully deprescribable. CONCLUSIONS Polypharmacy increases the risk of adverse drug reactions and hospitalizations in geriatric patients. Rational deprescribing of anticholinergics, benzodiazepines, antipsychotics, opioids, and proton pump inhibitors in selected patients may be a good first step to reducing this risk.