Miracle-dz/UniFAR-FTUs huggingface dataset:
Parkinson's disease detection using ensemble techniques and genetic algorithm

Parkinson's disease (PD) is a neurological disorder which progress by time. People suffering from PD experience shortage of Dopamine which is a chemical present in brain nerve cells. The symptoms of PD are tremor, rigidity, and slowness of movements and people with PD experience more severity by time progress. Therefore, the automation in early detection of PD is an important issue. In the literature, different classification methods have been proposed. Also, due to the high dimension of extracted features of voice, many feature selection algorithms have been developed. In this paper, we aim to propose a method for early detection of PD from voice recordings. The Genetic algorithm is used to select the optimal set of features which can reduce feature vector dimension from 22 to 6 features. We have achieved 96.55% and 98.28% detection rate by employing AdaBoost and Bagging algorithms for classification process, respectively.
Light Alloys Structural Behaviour in Severe Environmental Conditions

High strength-to-mass ratio light alloys, such as 7075-T6 aluminium alloys and Ti-6Al-4V titanium alloys, are commonly adopted for high performance structural components in the aeronautic, automotive and maritime sectors. For this reason, it is crucial to investigate the effects of the external environment on their mechanical properties, to avoid dramatic component failure. In the present work, experimental tests were performed on Ti-6Al-4V and 7075-T6 light alloys. Ti-6Al-4V notched flat dogbone specimens, with Kt = 1.18, were tested for quasi-static and SCC effects in a methanol-water aggressive environment at different concentrations. Rotating bending R = -1fatigue tests were performed on 7075-T6 in air and methanol environment, to evaluate the effects of an aggressive environment on the fatigue strength at 200’000 cycles. The influence of DLC and WC/C PVD coatings on fatigue limit at 200’000 cycles has been evaluated in air and aggressive environment, to assess their mechanical and protective effects on the 7075-T6 substrate
A 12-week integrative exercise program improves self-reported mindfulness and interoceptive awareness in war veterans with posttraumatic stress symptoms.

OBJECTIVE Innovative approaches to the treatment of war-related posttraumatic stress disorder (PTSD) are needed. We report on secondary psychological outcomes of a randomized controlled trial of integrative exercise (IE) using aerobic and resistance exercise with mindfulness-based principles and yoga. We expected-in parallel to observed improvements in PTSD intensity and quality of life-improvements in mindfulness, interoceptive bodily awareness, and positive states of mind. METHOD A total of 47 war veterans with PTSD were randomized to 12-week IE versus waitlist. Changes in mindfulness, interoceptive awareness, and states of mind were assessed by self-report standard measures. RESULTS Large effect sizes for the intervention were observed on Five-Facet Mindfulness Questionnaire Non-Reactivity (d = .85), Multidimensional Assessment of Interoceptive Awareness Body Listening (d = .80), and Self-Regulation (d = 1.05). CONCLUSION In a randomized controlled trial of a 12-week IE program for war veterans with PTSD, we saw significant improvements in mindfulness, interoceptive bodily awareness, and positive states of mind compared to a waitlist.
Nutritional programming of gastrointestinal tract development. Is the pig a good model for man?

The consequences of early-life nutritional programming in man and other mammalian species have been studied chiefly at the metabolic level. Very few studies, if any, have been performed in the gastrointestinal tract (GIT) as the target organ, but extensive GIT studies are needed since the GIT plays a key role in nutrient supply and has an impact on functions of the entire organism. The possible deleterious effects of nutritional programming at the metabolic level were discovered following epidemiological studies in human subjects, and confirmed in animal models. Investigating the impact of programming on GIT structure and function would need appropriate animal models due to ethical restrictions in the use of human subjects. The aim of the present review is to discuss the use of pigs as an animal model as a compromise between ethically acceptable animal studies and the requirement of data which can be interpolated to the human situation. In nutritional programming studies, rodents are the most frequently used model for man, but GIT development and digestive function in rodents are considerably different from those in man. In that aspect, the pig GIT is much closer to the human than that of rodents. The swine species is closely comparable with man in many nutritional and digestive aspects, and thus provides ample opportunity to be used in investigations on the consequences of nutritional programming for the GIT. In particular, the ‘sow–piglets’ dyad could be a useful tool to simulate the ‘human mother–infant’ dyad in studies which examine short-, middle- and long-term effects and is suggested as the reference model.
Fuelling quasars with hot gas

We consider a model for quasar formation in which massive black holes are formed and fuelled largely by the accretion of hot gas during the process of galaxy formation. In standard hierarchical collapse models, objects about the size of normal galaxies and larger form a dense hot atmosphere when they collapse. We show that if such an atmosphere forms a nearly ‘maximal’ cooling flow, then a central black hole can accrete at close to its Eddington limit. This leads to exponential growth of a seed black hole, resulting in a quasar in some cases. In this model, the first quasars form soon after the first collapses to produce hot gas. The hot gas is depleted as time progresses, mostly by cooling, so that the accretion rate eventually falls below the threshold for advection-dominated accretion, at which stage radiative efficiency plummets and any quasar turns off. A simple implementation of this model, incorporated into a semi-analytical model for galaxy formation, overproduces quasars when compared with observed luminosity functions, but is consistent with models of the X-ray background, which indicate that most accretion is obscured. It produces few quasars at high redshift owing to the lack of time needed to grow massive black holes. Quasar fuelling by hot gas provides a minimum level, sufficient to power most quasars at redshifts between one and two, to which other sources of fuel can be added. The results are sensitive to feedback effects, such as might result from radio jets and other outflows.
Liking Goes With Liking: An Intuitive Congruence Between Preference and Prominence

In a series of 8 experiments, we demonstrate the existence of a “labeling effect” wherein people intuitively relate preferred choices to prominently labeled cues (such as heads as opposed to tails in a coin toss) and vice versa. Importantly, the observed congruence is asymmetric—it does not manifest for nonprominent cues and nonpreferred choices. This is because the congruence is driven by a process of evaluative matching: prominent cues are liked, but nonprominent cues are neutral or at most slightly negative in contrast. When we test prominent, yet truly negatively labeled cues, we indeed find a matching with less liked products. We discuss the theoretical contributions to the study of preferences and decision making, as well as demonstrate the practical implications to researchers and practitioners by using this process to assess intuitive preferences and reduce the compromise effect.
Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy

The Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 1 (SHP-1), a non-receptor protein tyrosine phosphatase, has been reported as a negative regulator of phosphorylated signal transducer and activator of transcription 3 (STAT3) and linked to tumor development. In this present review, we will discuss the importance and function of SHP-1/p-STAT3 signaling in nonmalignant conditions as well as malignancies, its cross-talk with other pathways, the current clinical development and the potential role of inhibitors of this pathway in anticancer therapy and clinical relevance of SHP-1/p-STAT3 in cancers. Lastly, we will summarize and highlight work involving novel drugs/compounds targeting SHP-1/p-STAT3 signaling and combined strategies that were/are discovered in our and our colleagues’ laboratories.
Renal resistance thresholds during hypothermic machine perfusion and transplantation outcomes – a retrospective cohort study

Renal resistance (RR), of allografts undergoing hypothermic machine perfusion (HMP), is considered a measure of organ quality. We conducted a retrospective cohort study of adult deceased donor kidney transplant (KT) recipients whose grafts underwent HMP. Our aim was to evaluate whether RR is predictive of death‐censored graft failure (DCGF). Of 274 KT eligible for analysis, 59% were from expanded criteria donor. RR was modeled as a categorical variable, using a previously identified terminal threshold of 0.4, and 0.2 mmHg/ml/min (median in our cohort). Hazard ratios (HR) of DCGF were 3.23 [95% confidence interval (CI): 1.12–9.34, P = 0.03] and 2.67 [95% CI: 1.14–6.31, P = 0.02] in univariable models, and 2.67 [95% CI: 0.91–7.86, P = 0.07] and 2.42 [95% CI: 1.02–5.72, P = 0.04] in multivariable models, when RR threshold was 0.4 and 0.2, respectively. Increasing risk of DCGF was observed when RR over the course of HMP was modeled using mixed linear regression models: HR of 1.31 [95% CI: 1.07–1.59, P < 0.01] and 1.25 [95% CI: 1.00–1.55, P = 0.05], in univariable and multivariable models, respectively. This suggests that RR during HMP is a predictor of long‐term KT outcomes. Prospective studies are needed to assess the survival benefit of patients receiving KT with higher RR in comparison with staying wait‐listed.
Symptom trajectories throughout two family therapy treatments for adolescent anorexia nervosa

OBJECTIVE This study aimed to examine the trajectory of symptom remission and affective functioning throughout the course of two family-based treatments for adolescent anorexia nervosa (AN): conjoint family-based treatment (FBT) and parent-focused treatment (PFT). METHOD Participants were 107 adolescents (Mage = 15.5 years, SD = 1.5) with a primary diagnosis of AN who participated in a randomized clinical trial comparing FBT (N = 55) and PFT (N = 51). Patient weight and self-reported assessments of dietary restraint and positive and negative affect were recorded at regular intervals throughout treatment. RESULTS Multilevel models revealed increases in weight (β = 0.33, p < .001) and positive affect (β = 0.03, p < .001), and decreases in dietary restraint (β = -0.03, p < .001) and negative affect (β = -0.04, p < .001) over the course of treatment. No significant effects emerged by treatment type. DISCUSSION These findings suggest that PFT may bring about comparable trajectories of weight gain and reduced dietary restraint as conjoint FBT, despite adolescents not being directly involved in treatment. These findings also highlight that the exclusively behavioral focus throughout both PFT and FBT is associated with significant increments in positive affect and significant reductions in negative affect.
Effects of an herbicide on physiology, morphology, and fitness of the dung beetle Euoniticellus intermedius (Coleoptera: Scarabaeidae)

Some agrochemical compounds threaten nontarget organisms and their functions in the ecosystem. The authors experimentally evaluated the effects of one of the most common herbicide mixtures used worldwide, containing 2,4‐dichlorophenoxyacetic acid and picloram, on dung beetles, which play fundamental roles in the function of natural and managed ecosystems. The present study employed techniques of physiology and geometric morphometrics, besides including fitness measurements, to assess the effects of the herbicide in the introduced beetle Euoniticellus intermedius. Because herbicide components promote oxidative stress and affect survival in certain insects, the authors predicted negative effects on the beetles. Unexpectedly, no effect of herbicide concentration was found on clutch size, sex ratio, and fluctuating asymmetry, and it even increased physiological condition and body size in exposed beetles. Because the studied species presents 2 male morphs, the authors, for the first time, evaluated the effect of a pollutant on the ratio of these morphs. Contrary to the prediction, the herbicide mixture increased the proportion of major males. Thus, the herbicide does not threaten populations of the studied beetles. The present study discusses how both negative and positive effects of pollutants on wild animals modify natural and sexual selection processes occurring in nature, which ultimately impact population dynamics. The authors recommend the use of physiological and geometric morphometrics techniques to assess the impact of pollutants on nontarget animals. Environ Toxicol Chem 2017;36:96–102. © 2016 SETAC
iDial

Smart wearable devices have become pervasive and are playing a more important role in our everyday lives. However, the small screen size and very few buttons make the interaction and control cumbersome and inconvenient. Previous solutions to mitigate this problem either require extra dedicated hardware, or instrument the user's fingers with special purpose sensors, limiting their real-life applications. We present iDial, a novel real time approach that enables a virtual dial plate on the hand back, extending the interaction beyond the small screen of wearable devices. iDial only employs the already built-in microphone and motion sensors of the commercial-off-the-shelf (COTS) device to facilitate interactions between user and wearable, without any extra hardware involved. The key idea is to exploit the acoustic signatures extracted from passive subtle acoustic signals to accurately recognize the virtual keys input on the skin of the hand back. We innovatively locate the virtual keys on the 4 pieces of metacarpal bones to significantly reduce the possibility of casual inputs. iDial also takes advantages of the motion sensor fusion already available inside the wearable to achieve robustness against the ambient noise and human voices efficiently. We design and implement iDial on the Samsung Gear S2 smartwatch. Our extensive experiments show that iDial is able to achieve an average recognition accuracy of 96.7%, and maintain high accuracies across varying user behaviors and different environments. iDial achieves a below 0.5s end-to-end latency with all the computations and processes happening at the cheap commodity wearable.
Evaluating the Difference between Virtual and Paper-Based Clinical Cases in Family Medicine Undergraduate Education

Introduction A “virtual patient” is defined as a computer program which simulates real patients' cases. The aim of this study was to determine whether the inclusion of virtual patients affects the level of factual knowledge of family medicine students at the undergraduate level. Methods This was a case-controlled prospective study. The students were randomly divided into experimental (EG: N = 51) and control (CG: N = 48) groups. The students in the EG were asked to practice diagnosis using virtual patients instead of the paper-based clinical cases which were solved by the students in the CG. The main observed variable in the study was knowledge of family medicine, determined by 50 multiple choice questions (MCQs) about knowledge of family medicine. Results There were no statistically significant differences in the groups' initial knowledge. At the final assessment of knowledge, there were no statistically significant differences between the groups, but there was a statistically significant difference between their initial and final knowledge. Conclusions The study showed that adding virtual patient cases to the curriculum, instead of paper clinical cases, did not affect the level of factual knowledge about family medicine. Virtual patients can be used, but a significant educational outcome is not expected.
Drought consistently alters the composition of soil fungal and bacterial communities in grasslands from two continents

The effects of short‐term drought on soil microbial communities remain largely unexplored, particularly at large scales and under field conditions. We used seven experimental sites from two continents (North America and Australia) to evaluate the impacts of imposed extreme drought on the abundance, community composition, richness, and function of soil bacterial and fungal communities. The sites encompassed different grassland ecosystems spanning a wide range of climatic and soil properties. Drought significantly altered the community composition of soil bacteria and, to a lesser extent, fungi in grasslands from two continents. The magnitude of the fungal community change was directly proportional to the precipitation gradient. This greater fungal sensitivity to drought at more mesic sites contrasts with the generally observed pattern of greater drought sensitivity of plant communities in more arid grasslands, suggesting that plant and microbial communities may respond differently along precipitation gradients. Actinobateria, and Chloroflexi, bacterial phyla typically dominant in dry environments, increased their relative abundance in response to drought, whereas Glomeromycetes, a fungal class regarded as widely symbiotic, decreased in relative abundance. The response of Chlamydiae and Tenericutes, two phyla of mostly pathogenic species, decreased and increased along the precipitation gradient, respectively. Soil enzyme activity consistently increased under drought, a response that was attributed to drought‐induced changes in microbial community structure rather than to changes in abundance and diversity. Our results provide evidence that drought has a widespread effect on the assembly of microbial communities, one of the major drivers of soil function in terrestrial ecosystems. Such responses may have important implications for the provision of key ecosystem services, including nutrient cycling, and may result in the weakening of plant–microbial interactions and a greater incidence of certain soil‐borne diseases.
Fundamental issues that govern the rotation of FRP retrofitted RC columns and beams: The intractable plastic hinge ductility problem

There is often a perception that FRP retrofitted concrete structures are unable to redistribute stress resultants nor absorb energy due to a lack of rotational capacity because FRP is a brittle material and the interface bond between the FRP plate and concrete is also brittle. However in contrast to this perception, there is clear experimental evidence to show that FRP plating techniques can produce ductile members. Hence, it should be possible to develop ductility design rules for FRP strengthened reinforced concrete structures to considerably widen the application of FRP plating which is the subject of this paper. It is shown that the major problem is not in quantifying the rotational limit due to FRP plate debonding or fracture but in quantifying the rotational limit due to concrete softening which has been an intractable problem for over fifty years.
Protein Phosphatase 2A in the Regulation of Wnt Signaling, Stem Cells, and Cancer

Protein phosphorylation is a ubiquitous cellular process that allows for the nuanced and reversible regulation of protein activity. Protein phosphatase 2A (PP2A) is a heterotrimeric serine-threonine phosphatase—composed of a structural, regulatory, and catalytic subunit—that controls a variety of cellular events via protein dephosphorylation. While much is known about PP2A and its basic biochemistry, the diversity of its components—especially the multitude of regulatory subunits—has impeded the determination of PP2A function. As a consequence of this complexity, PP2A has been shown to both positively and negatively regulate signaling networks such as the Wnt pathway. Wnt signaling modulates major developmental processes, and is a dominant mediator of stem cell self-renewal, cell fate, and cancer stem cells. Because PP2A affects Wnt signaling both positively and negatively and at multiple levels, further understanding of this complex dynamic may ultimately provide insight into stem cell biology and how to better treat cancers that result from alterations in Wnt signaling. This review will summarize literature that implicates PP2A as a tumor suppressor, explore PP2A mutations identified in human malignancy, and focus on PP2A in the regulation of Wnt signaling and stem cells so as to better understand how aberrancy in this pathway can contribute to tumorigenesis.
Real-Time Rotational Activity Detection in Atrial Fibrillation

Rotational activations, or spiral waves, are one of the proposed mechanisms for atrial fibrillation (AF) maintenance. We present a system for assessing the presence of rotational activity from intracardiac electrograms (EGMs). Our system is able to operate in real-time with multi-electrode catheters of different topologies in contact with the atrial wall, and it is based on new local activation time (LAT) estimation and rotational activity detection methods. The EGM LAT estimation method is based on the identification of the highest sustained negative slope of unipolar signals. The method is implemented as a linear filter whose output is interpolated on a regular grid to match any catheter topology. Its operation is illustrated on selected signals and compared to the classical Hilbert-Transform-based phase analysis. After the estimation of the LAT on the regular grid, the detection of rotational activity in the atrium is done by a novel method based on the optical flow of the wavefront dynamics, and a rotation pattern match. The methods have been validated using in silico and real AF signals.
Effects of hypochlorite exposure on morphology and trace organic contaminant rejection by NF/RO membranes

The impacts of membrane degradation due to chlorine attack on the rejection of inorganic salts and trace organic contaminants by nanofiltration (NF) and reverse osmosis (RO) membranes were investigated in this study. The rejection of trace contaminants was examined at environmentally relevant concentrations. Changes in the membrane surface morphology were observed as a result of chlorine exposure. A small increase in rejection was consistently observed with all four membranes selected in this study after being exposed to a low concentration of hypochlorite (100 ppm). In contrast, a higher concentration of hypochlorite (i.e., 2000 ppm) could be detrimental to the membrane separation capacity. Membranes with severe chlorine impact showed a considerable decrease in rejection over filtration time, possibly due to rearrangement of the polyamide chains under the influence of chlorine degradation and filtration pressure. The reported results indicate that loose NF membranes are more sensitive to chlorine exposure than RO membranes. The impact of hypochlorite exposure (both positive and negative) on rejection is dependent on the strength of the hypochlorite solution and is more significant for the neutral carbamazepine compound than the negatively charged sulfamethoxazole. Disciplines Engineering | Science and Technology Studies Publication Details Simon, A. & Nghiem, L. D. (2014). Effects of hypochlorite exposure on morphology and trace organic contaminant rejection by NF/RO membranes. Membrane Water Treatment, 5 (4), 235-250. This journal article is available at Research Online: http://ro.uow. edu.au/eispapers/3108