Miracle-dz/UniFAR-FTUs huggingface dataset:
A Modeling System to Assess Land Cover Land Use Change Effects on SAV Habitat in the Mobile Bay Estuary

Estuarine ecosystems are largely influenced by watersheds directly connected to them. In the Mobile Bay, Alabama watersheds we examined the effect of land cover and land use (LCLU) changes on discharge rate, water properties, and submerged aquatic vegetation, including freshwater macrophytes and seagrasses, throughout the estuary. LCLU scenarios from 1948, 1992, 2001, and 2030 were used to influence watershed and hydrodynamic models and evaluate the impact of LCLU change on shallow aquatic ecosystems. Overall, our modeling results found that LCLU changes increased freshwater flows into Mobile Bay altering temperature, salinity, and total suspended sediments (TSS). Increased urban land uses coupled with decreased agricultural/pasture lands reduced TSS in the water column. However, increased urbanization or agricultural/pasture land coupled with decreased forest land resulted in higher TSS concentrations. Higher sediment loads were usually strongly correlated with higher TSS levels, except in areas where a large extent of wetlands retained sediment discharged during rainfall events. The modeling results indicated improved water clarity in the shallow aquatic regions of Mississippi Sound and degraded water clarity in the Wolf Bay estuary. This integrated modeling approach will provide new knowledge and tools for coastal resource managers to manage shallow aquatic habitats that provide critical ecosystem services.
Aerial manipulation robot composed of an autonomous helicopter and a 7 degrees of freedom industrial manipulator

This paper is devoted to a system for aerial manipulation, composed of a helicopter and an industrial manipulator. The usage of an industrial manipulator is motivated by practical applications which were identified in different cooperation projects with the industry. We address the coupling between manipulator and helicopter and show that even in case when we have an ideal controller for manipulator and a highperformance controller for helicopter, an unbounded energy flow can be generated by internal forces between helicopter and manipulator if both controllers are used independently. To solve this problem we propose a new kinematical coupling for control by introducing an additional manipulation DoF realized by helicopter rotation around its yaw axis. The new experimental setup and required modifications in the manipulator controller for this purpose are described. Further, we propose dynamical coupling which is implemented by modification of the helicopter controller feeding the interaction force/torque, measured between manipulator base and fuselage, directly to the actuators of the rotor blades. At the end, we present experimental results for aerial manipulation and their analysis.
The role of cultural models of self-worth in vicarious experiences of wrongdoing

Title of Document: The Role of Cultural Models of Self-Worth in Vicarious Experiences of Wrongdoing Sarah Louise Lyons, Master of Science, 2012 Directed By: Professor Michele Gelfand, Department of Psychology This research sought to understand why people from different cultures respond in fundamentally different ways to their own ingroup transgressions. We predicted that in face cultures, where self-worth is defined by one’s reputation, ingroup transgressions would elicit vicarious shame and withdrawal tendencies, especially in public; in dignity cultures, however, where self-worth does not depend on reputation and justice is a focal concern, ingroup transgressions would elicit vicarious guilt and reparative behavior. In Study 1, participants responded to hypothetical ingroup transgressions. In Study 2, sorority and fraternity members recalled a time when a group member committed a wrongdoing. In Study 3, we simulated a real ingroup offense in the lab. We found partial support for our hypotheses in Study 1; face predicted distancing behavior, mediated by image-threat appraisals and shame, but only in public. The results in Studies 2 and 3 were less clear, and suggest evidence for motivated distortion. THE ROLE OF CULTURAL MODELS OF SELF-WORTH IN VICARIOUS EXPERIENCES OF WRONGDOING
Origin and Evolution of the Sodium -Pumping NADH: Ubiquinone Oxidoreductase

The sodium -pumping NADH: ubiquinone oxidoreductase (Na+-NQR) is the main ion pump and the primary entry site for electrons into the respiratory chain of many different types of pathogenic bacteria. This enzymatic complex creates a transmembrane gradient of sodium that is used by the cell to sustain ionic homeostasis, nutrient transport, ATP synthesis, flagellum rotation and other essential processes. Comparative genomics data demonstrate that the nqr operon, which encodes all Na+-NQR subunits, is found in a large variety of bacterial lineages with different habitats and metabolic strategies. Here we studied the distribution, origin and evolution of this enzymatic complex. The molecular phylogenetic analyses and the organizations of the nqr operon indicate that Na+-NQR evolved within the Chlorobi/Bacteroidetes group, after the duplication and subsequent neofunctionalization of the operon that encodes the homolog RNF complex. Subsequently, the nqr operon dispersed through multiple horizontal transfer events to other bacterial lineages such as Chlamydiae, Planctomyces and α, β, γ and δ -proteobacteria. Considering the biochemical properties of the Na+-NQR complex and its physiological role in different bacteria, we propose a detailed scenario to explain the molecular mechanisms that gave rise to its novel redox- dependent sodium -pumping activity. Our model postulates that the evolution of the Na+-NQR complex involved a functional divergence from its RNF homolog, following the duplication of the rnf operon, the loss of the rnfB gene and the recruitment of the reductase subunit of an aromatic monooxygenase.
SHORTENED PEGINTERFERON AND RIBAVIRIN TREATMENT FOR CHRONIC HEPATITIS C

Background: Peginterferon alfa and ribavirin combination therapy is an effective treatment for many patients with chronic hepatitis C virus (HCV). Reducing the length of treatment may be advantageous. We performed a systematic review and economic evaluation to assess shorter treatment duration of this regimen. Methods: We searched fourteen bibliographic databases (including The Cochrane Library, Medline, and Embase) from 2000 to October 2009 and consulted experts and drug manufacturers. Eligible articles were randomized controlled trials (RCTs) selected according to predefined criteria. We undertook an economic evaluation to assess the cost-effectiveness of shortened treatment versus standard treatment in the UK. Results: Six trials were included. In the sub-group of patients who had low viral load (LVL) and a rapid virological response (RVR), there were no statistically significant differences in sustained virological response (SVR) rates between patients who received standard treatment (range, 83 percent to 100 percent) and those who received shortened courses (range 84 percent to 96 percent) (24 weeks for genotype 1, 16 weeks for genotype 2/3). Shortened treatment resulted in cost savings, but in some scenarios also resulted in poorer outcome, compared with standard treatment. This requires a judgment to be made on the value of the quality-adjusted life-year loss resulting from adopting a shorter treatment regimen, if shorter treatment is associated with a lower SVR than standard treatment duration. Conclusions: For chronic HCV patients who have LVL and achieve an RVR, shortened peginterferon and ribavirin combination therapy could be considered as a viable treatment option.
Multimodality Imaging of Abnormal Vascular Perfusion and Morphology in Preclinical 9L Gliosarcoma Model

BACKGROUND This study demonstrates that a dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) perfusion parameter may indicate vascular abnormality in a brain tumor model and reflects an effect of dexamethasone treatment. In addition, X-ray computed tomography (CT) measurements of vascular tortuosity and tissue markers of vascular morphology were performed to investigate the underpinnings of tumor response to dexamethasone. METHODOLOGY/PRINCIPAL FINDINGS One cohort of Fisher 344 rats (N = 13), inoculated intracerebrally with 9L gliosarcoma cells, was treated with dexamethasone (i.p. 3 mg/kg/day) for five consecutive days, and another cohort (N = 11) was treated with equal volume of saline. Longitudinal DSC-MRI studies were performed at the first (baseline), third and fifth day of treatments. Relative cerebral blood volume (rCBV) was significantly reduced on the third day of dexamethasone treatment (0.65 ± .13) as compared to the fifth day during treatment (1.26 ±.19, p < 0.05). In saline treated rats, relative CBV gradually increased during treatment (0.89 ±.13, 1.00 ± .21, 1.13 ± .23) with no significant difference on the third day of treatment (p>0.05). In separate serial studies, microfocal X-ray CT of ex vivo brain specimens (N = 9) and immunohistochemistry for endothelial cell marker anti-CD31 (N = 8) were performed. Vascular morphology of ex vivo rat brains from micro-CT analysis showed hypervascular characteristics in tumors, and both vessel density (41.32 ± 2.34 branches/mm(3), p<0.001) and vessel tortuosity (p<0.05) were significantly reduced in tumors of rats treated with dexamethasone compared to saline (74.29 ± 3.51 branches/mm(3)). The vascular architecture of rat brain tissue was examined with anti-CD31 antibody, and dexamethasone treated tumor regions showed reduced vessel area (16.45 ± 1.36 µm(2)) as compared to saline treated tumor regions (30.83 ± 4.31 µm(2), p<0.001) and non-tumor regions (22.80 ± 1.11 µm(2), p<0.01). CONCLUSIONS/SIGNIFICANCE Increased vascular density and tortuosity are culprit to abnormal perfusion, which is transiently reduced during dexamethasone treatment.
Model-Based Design and Experimental Validation of Control Modules for Neuromodulation Devices

Goal: The goal of this paper is to propose a model-based control design framework, adapted to the development of control modules for medical devices. A particular example is presented in which instantaneous heart rate is regulated in real-time, by modulating, in an adaptive manner, the current delivered to the vagus nerve by a neuromodulator. Methods: The proposed framework couples a control module, based on a classical PI controller, a mathematical model of the medical device, and a physiological model representing the cardiovascular responses to vagus nerve stimulation (VNS). In order to analyze and evaluate the behavior of the device, different control parameters are tested on a “virtual population,” generated with the model, according to the Latin Hypercube sampling method. In particular, sensitivity analyses are applied for the identification of a domain of interest in the space of the control parameters. The obtained control parameter domain has been validated in an experimental evaluation on six sheep. Results: A range of control parameters leading to accurate results was successfully estimated by the proposed model-based design method. Experimental evaluation of the control parameters inside such a domain led to the best compromise between accuracy and time response of the VNS control. Conclusion: The feasibility and usefulness of the proposed model-based design method were shown, leading to a functional, real-time closed-loop control of the VNS for the regulation of heart rate.
Non-coeliac gluten sensitivity: piecing the puzzle together

The avoidance of wheat- and gluten-containing products is a worldwide phenomenon. While coeliac disease is well-established, much remains unknown about whether gluten can be a trigger of gastrointestinal and/or extra-intestinal symptoms in patients without coeliac disease. In this article, we discuss the latest scientific evidence and our current understanding for the possible mechanisms of this largely ambiguous group, termed ‘non-coeliac gluten sensitive’ (NCGS). We can conclude that NCGS should be regarded as an independent disease outside of coeliac disease and wheat allergy, and that the number of patients affected is likely to be limited. Many questions remain unanswered and it needs to be verified whether the elimination of dietary gluten alone is sufficient for the control of symptoms, and to understand the overlap with other components of wheat.
Polysemy, Aspect and Modality in Brazilian Portuguese: The Case for a Cognitive Explanation of Grammar - eScholarship

Polysemy, Aspect and Modality in Brazilian Portuguese: The Case for a Cognitive Explanation of Grammar By Maria-Margarida Martins Salomao M.A. (Federal University of Rio de Janeiro, Brazil) 1977 M.A. (University of California) 1980 DISSERTATION Submitted in partial satisfaction of the requirements for the degree of DOCTOR OF PHILOSOPHY in LINGUISTICS in the GRADUATE DIVISION of the UNIVERSITY OF CALIFORNIA at BERKELEY Approved; ! hair iiLi it/li LL) i00 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
The Value of Supplemental Prognostic Tests for the Preoperative Assessment of Idiopathic Normal-pressure Hydrocephalus

OBJECTIVE:The diagnosis and management of idiopathic normal-pressure hydrocephalus (INPH) remains unclear. Moreover, the value of supplementary tests to predict which patients would benefit from placement of a shunt has not been established. This report develops evidence-based guidelines for the use of supplementary tests as an aid in prognosis. METHODS:MEDLINE searches from 1966 to the present were undertaken by use of the query NPH, normal-pressure hydrocephalus, lumbar drain, CSF [cerebrospinal fluid] tap test, and external CSF drainage in humans. This resulted in 242 articles. To provide a scientific, evidence-based review, we have chosen to restrict our analysis to clinically relevant studies usually consisting of large numbers of shunted NPH patients. Studies that did not specify INPH or secondary NPH were considered in a separate evidentiary table. RESULTS:Evidence-based guidelines for use in supplementary tests have been developed. A positive response to a 40- to 50-ml tap test has a higher degree of certainty for a favorable response to shunt placement than can be obtained by clinical examination. However, the tap test cannot be used as an exclusionary test because of its low sensitivity (26–61%). Determination of the CSF outflow resistance via an infusion test carries a higher sensitivity (57–100%) compared with the tap test and a similar positive predictive value of 75 to 92%. Prolonged external lumbar drainage in excess of 300 ml is associated with high sensitivity (50–100%) and high positive predictive value (80–100%). CONCLUSION:To date, a single standard for the prognostic evaluation of INPH patients is lacking. However, supplemental tests can increase predictive accuracy for prognosis to greater than 90%. Additional multicenter prospective randomized clinical trials are needed.
Prevalence of SAP gene defects in male patients diagnosed with common variable immunodeficiency

The molecular basis of common variable immunodeficiency (CVID) is undefined, and diagnosis requires exclusion of other diseases including X‐linked lymphoproliferative disease (XLP). This rare disorder of immunedysregulation presents typically after Epstein–Barr virus infection and results from defects in the SAP (SLAM associated protein) gene. SAP mutations have been found in a few patients diagnosed previously as CVID, suggesting that XLP may mimic CVID, but no large‐scale analysis of CVID patients has been undertaken. We therefore analysed 60 male CVID and hypogammaglobulinaemic patients for abnormalities in SAP protein expression and for mutations in the SAP gene. In this study only one individual, who was found later to have an X‐linked family history, was found to have a genomic mutation leading to abnormal SAP cDNA and protein expression. These results demonstrate that SAP defects are rarely observed in CVID patients. We suggest that routine screening of SAP may only be necessary in patients with other suggestive clinical features.
Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin

The M band of sarcomeric muscle is a highly complex structure which contributes to the maintenance of the regular lattice of thick filaments. We propose that the spatial coordination of this assembly is regulated by specific interactions of myosin filaments, the M band protein myomesin and the large carboxy‐terminal region of titin. Corresponding binding sites between these proteins were identified. Myomesin binds myosin in the central region of light meromyosin (LMM, myosin residues 1506–1674) by its unique amino‐terminal domain My1. A single titin immunoglobulin domain, m4, interacts with a myomesin fragment spanning domains My4–My6. This interaction is regulated by phosphorylation of Ser482 in the linker between myomesin domains My4 and My5. Myomesin phosphorylation at this site by cAMP‐dependent kinase and similar or identical activities in muscle extracts block the association with titin. We propose that this demonstration of a phosphorylation‐controlled interaction in the sarcomeric cytoskeleton is of potential relevance for sarcomere formation and/or turnover. It also reveals how binding affinities of modular proteins can be regulated by modifications of inter‐domain linkers.
Mapping the recovery stories of drinkers and drug users in Glasgow: quality of life and its associations with measures of recovery capital.

INTRODUCTION AND AIMS The study investigates what 'recovery' means for those who describe themselves as in alcohol or drug recovery. DESIGN AND METHODS The project used multiple methods-snowballing, recruitment through recovery groups and advertisements in local press-to recruit 205 people (107 in alcohol and 98 in heroin recovery) who reported a lifetime dependence on alcohol and/or heroin; had not used their primary substance in the last year and perceived themselves to be either recovered or in recovery. They were interviewed by researchers using a structured questionnaire reported in the current paper and a semi-structured interview reported elsewhere. RESULTS The average time dependent for heroin users was 10.8 years and for drinkers 15.7years, but onset and desistance were earlier for heroin. Longer time since last use of alcohol or heroin was associated with better quality of life. Greater engagement in meaningful activities was associated with better functioning, and was associated with quality of life, followed by number of peers in recovery in the social network. Heroin users in abstinent recovery generally reported better functioning than those in maintained recovery. DISCUSSION AND CONCLUSIONS Recovery experiences vary widely, but better functioning is typically reported after longer periods and is associated with supportive peer groups and more engagement in meaningful activities, and supports models promoting the development of peer networks immersed in local communities.
An empirical investigation of habitual usage and past usage on technology acceptance evaluations and continuance intention

Although much research has examined information technology (IT) usage that involves deliberate evaluation and decision-making, we know less about automatic use that occurs spontaneously with little conscious effort. In this study we have investigated this issue by studying how habitual usage and past usage may influence the predicting power of perceived ease of use (PEOU) and perceived usefulness (PU) on intention. Using 232 cross-sectional responses from subjects who have continuously used the Google search engine, the results show that as individuals get into the habit of continuously using a system, the predicting power of PU and PEOU on intention is diluted by the addition of either habitual usage or past usage. This indicates that the stronger the habitual use of the Google search engine, the less conscious planning is involved, and the relationship between subjects' evaluations of PU/PEOU and their intention to use weakens. Furthermore, our study shows that past usage, often employed as a proxy of habitual usage, demonstrates a similar effect but differs in the predicting power from habitual usage. This result suggests that researchers may employ habitual usage for studies of post-adoption phenomenon concerning continuous information system usage.
CEO Ambivalence and Responses to Strategic Issues

We examine how executives' ambivalent evaluation of a strategic issue relates to organizational actions taken in response. Ambivalence occurs when a decision maker evaluates an issue as simultaneously positive and negative, a state that has received scant attention in organizational research. We integrate findings in social psychology with the behavioral theory of the firm to suggest how executives' ambivalence prompts wider and more vigorous search for action responses and enables broader participation. Data from a two-wave survey of 104 German CEOs who evaluated the enlargement of the European Union in 2004 and reported their organizations' responses show that organizations whose CEOs evaluated the event as both positive and negative were more likely to take action when both evaluations were also strongly held. The reported actions were also of greater scope, novelty, and riskiness. The study contributes to research on organizational decision making by theorizing the role of top executives' ambivalence and by providing a first systematic test of how ambivalence affects responses to strategic issues.
Activation of the intrarenal renin-angiotensin-system in murine polycystic kidney disease

The mechanism for early hypertension in polycystic kidney disease (PKD) has not been elucidated. One potential pathway that may contribute to the elevation in blood pressure in PKD is the activation of the intrarenal renin‐angiotensin‐system (RAS). For example, it has been shown that kidney cyst and cystic fluid contains renin, angiotensin II (AngII), and angiotensinogen (Agt). Numerous studies suggest that ciliary dysfunction plays an important role in PKD pathogenesis. However, it is unknown whether the primary cilium affects the intrarenal RAS in PKD. The purpose of this study was to determine whether loss of cilia or polycystin 1 (PC1) increases intrarenal RAS in mouse model of PKD. Adult Ift88 and Pkd1 conditional floxed allele mice with or without cre were administered tamoxifen to induce global knockout of the gene. Three months after tamoxifen injection, kidney tissues were examined by histology, immunofluorescence, western blot, and mRNA to assess intrarenal RAS components. SV40 immortalized collecting duct cell lines from hypomorphic Ift88 mouse were used to assess intrarenal RAS components in collecting duct cells. Mice without cilia and PC1 demonstrated increased kidney cyst formation, systolic blood pressure, prorenin, and kidney and urinary angiotensinogen levels. Interestingly immunofluorescence study of the kidney revealed that the prorenin receptor was localized to the basolateral membrane of principal cells in cilia (−) but not in cilia (+) kidneys. Collecting duct cAMP responses to AngII administration was greater in cilia (−) vs. cilia (+) cells indicating enhanced intrarenal RAS activity in the absence of cilia. These data suggest that in the absence of cilia or PC1, there is an upregulation of intrarenal RAS components and activity, which may contribute to elevated blood pressure in PKD.