Miracle-dz/UniFAR-FTUs huggingface dataset:
Crawling to Collapse: Ecologically Unsound Ornamental Invertebrate Fisheries

Background Fishery management has historically been an inexact and reactionary discipline, often taking action only after a critical stock suffers overfishing or collapse. The invertebrate ornamental fishery in the State of Florida, with increasing catches over a more diverse array of species, is poised for collapse. Current management is static and the lack of an adaptive strategy will not allow for adequate responses associated with managing this multi-species fishery. The last decade has seen aquarium hobbyists shift their display preference from fish-only tanks to miniature reef ecosystems that include many invertebrate species, creating increased demand without proper oversight. The once small ornamental fishery has become an invertebrate-dominated major industry supplying five continents. Methodology/Principal Findings Here, we analyzed the Florida Marine Life Fishery (FLML) landing data from 1994 to 2007 for all invertebrate species. The data were organized to reflect both ecosystem purpose (in the wild) and ecosystem services (commodities) for each reported species to address the following question: Are ornamental invertebrates being exploited for their fundamental ecosystem services and economic value at the expense of reef resilience? We found that 9 million individuals were collected in 2007, 6 million of which were grazers. Conclusions/Significance The number of grazers now exceeds, by two-fold, the number of specimens collected for curio and ornamental purposes altogether, representing a major categorical shift. In general, landings have increased 10-fold since 1994, though the number of licenses has been dramatically reduced. Thus, despite current management strategies, the FLML Fishery appears to be crawling to collapse.
In vitro anti-bacterial and anti-adherence effects of Lactobacillus delbrueckii subsp bulgaricus on Escherichia coli

Considering the emergence of antibiotic resistance, scientists are interested in using new antimicrobial agents in the treatment of infectious diseases including infections of the enteric systems. Lactic acid bacteria have the great potential to produce antimicrobial compounds that inhibit and control pathogenic bacteria. The aim of this study was to determine the anti-bacterial and anti-adherence properties of Lactobacillus delbrueckii subsp bulgaricus against Escherichia coli. The antibacterial activity of L. delbrueckii was investigated using disc diffusion and spot on lawn methods. In vitro anti-adhesion effect of L. delbrueckii against E. coli was examined using Caco-2 cells. In anti-adhesion assay, three competition conditions including competitive inhibition, adhesion inhibition, and displacement were examined. In spot on lawn method the zone of growth inhibition of E. coli by L. delbrueckii was 21.1 mm. The cell free supernatant of L. delbrueckii showed a good antibacterial activity against E. coli which was mainly related to lactic acid produced by L. delbrueckii. When two bacteria added simultaneously (competitive inhibition) degree of inhibition of E. coli binding by L. delbrueckii was 77%. In adhesion inhibition assay, L. delbrueckii was able to exclude E. coli adherence by around 43.5%. Displacement assay showed that L. delbrueckii had strong displacement ability toward E. coli and reduction of E. coli attachment by bound L. delbrueckii was 81.3%. The results suggest that L. delbrueckii may be able to inhibit E. coli infection in the gut; however more studies including in vivo studies need to be performed.
Selection of the best maintenance approach in the maritime industry under fuzzy multiple attributive group decision-making environment

Many maintenance approaches have been developed and applied successfully in a variety of sectors such as aviation and nuclear industries over the years. Some of those have also been employed in the maritime industry such as condition-based maintenance; however, choosing the best maintenance approach has always been a big challenge due to the involvement of many attributes and alternatives which can also be associated with multiple experts and vague information. In order to accommodate these aspects, and as part of an overall novel Reliability and Criticality Based Maintenance strategy, an existing fuzzy multiple attributive group decision-making technique is employed in this study, which is further enhanced with the use of Analytical Hierarchy Process to obtain a better weighting of the maintenance attributes used. The fuzzy multiple attributive group decision-making technique has three distinctive stages, namely rating, aggregation and selection in which multiple experts’ subjective judgments are processed and aggregated to be able to arrive at a ranking for a finite number of maintenance options. To demonstrate the applicability in a real-life industrial context, the technique is exemplified by selecting the best maintenance approach for shipboard equipment such as the diesel generator system of a vessel. The results denote that preventive maintenance is the best approach closely followed by predictive maintenance, thus steering away from the ship corrective maintenance framework and increasing overall ship system reliability and availability.
correlate with coordinated hormone-induced gene regulation Distinct structural transitions of chromatin topological domains Material Supplemental

Material Supplemental http://genesdev.cshlp. org/content/suppl/2014/09/29/28.19. 2151.DC1. html References http://genesdev.cshlp. org/content/28/19/2151.full. html#ref-list-1 This article cites 45 articles, 15 of which can be accessed free at: License Commons Creative . http://creativecommons.org/licenses/by-nc/4.0/ at Creative Commons License (Attribution-NonCommercial 4.0 International), as described ). After six months, it is available under a http://genesdev.cshlp. org/site/misc/terms.xhtml six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first
A Genome-Wide Association Study Points out the Causal Implication of SOX9 in the Sex-Reversal Phenotype in XX Pigs

Among farm animals, pigs are known to show XX sex-reversal. In such cases the individuals are genetically female but exhibit a hermaphroditism, or a male phenotype. While the frequency of this congenital disease is quite low (less than 1%), the economic losses are significant for pig breeders. These losses result from sterility, urogenital infections and the carcasses being downgraded because of the risk of boar taint. It has been clearly demonstrated that the SRY gene is not involved in most cases of sex-reversal in pigs, and that autosomal recessive mutations remain to be discovered. A whole-genome scan analysis was performed in the French Large-White population to identify candidate genes: 38 families comprising the two non-affected parents and 1 to 11 sex-reversed full-sib piglets were genotyped with the PorcineSNP60 BeadChip. A Transmission Disequilibrium Test revealed a highly significant candidate region on SSC12 (most significant p-value<4.65.10-10) containing the SOX9 gene. SOX9, one of the master genes involved in testis differentiation, was sequenced together with one of its main regulatory region Tesco. However, no causal mutations could be identified in either of the two sequenced regions. Further haplotype analyses did not identify a shared homozygous segment between the affected pigs, suggesting either a lack of power due to the SNP properties of the chip, or a second causative locus. Together with information from humans and mice, this study in pigs adds to the field of knowledge, which will lead to characterization of novel molecular mechanisms regulating sexual differentiation and dysregulation in cases of sex reversal.
Numerical Analysis of Controlling Welding Deformation of the Wall Plate of Large Cylindrical Structure by Pre-Stress Method

During the welding of the wall plate of cylindrical structure, the edges of cylinder generates obvious wave-like deformation and affects subsequent assembly. In this paper, based on the numerical simulation method, welding deformation controlling by pre-stress method is studied. The effects of the pre-stress level and the welding sequence on the final deformation are discussed. The results show that the level of pre-stress can obviously control the welding deformation of the longitudinal beams, but can not control the welding deformation of transverse beams. Using the selected welding sequence: welding transverse beams firstly, exerting pre-stress, and then welding longitudinal beams, this welding sequence can reduce the wave-like deformation after welding.
Flux Imbalance Analysis and the Sensitivity of Cellular Growth to Changes in Metabolite Pools

Stoichiometric models of metabolism, such as flux balance analysis (FBA), are classically applied to predicting steady state rates - or fluxes - of metabolic reactions in genome-scale metabolic networks. Here we revisit the central assumption of FBA, i.e. that intracellular metabolites are at steady state, and show that deviations from flux balance (i.e. flux imbalances) are informative of some features of in vivo metabolite concentrations. Mathematically, the sensitivity of FBA to these flux imbalances is captured by a native feature of linear optimization, the dual problem, and its corresponding variables, known as shadow prices. First, using recently published data on chemostat growth of Saccharomyces cerevisae under different nutrient limitations, we show that shadow prices anticorrelate with experimentally measured degrees of growth limitation of intracellular metabolites. We next hypothesize that metabolites which are limiting for growth (and thus have very negative shadow price) cannot vary dramatically in an uncontrolled way, and must respond rapidly to perturbations. Using a collection of published datasets monitoring the time-dependent metabolomic response of Escherichia coli to carbon and nitrogen perturbations, we test this hypothesis and find that metabolites with negative shadow price indeed show lower temporal variation following a perturbation than metabolites with zero shadow price. Finally, we illustrate the broader applicability of flux imbalance analysis to other constraint-based methods. In particular, we explore the biological significance of shadow prices in a constraint-based method for integrating gene expression data with a stoichiometric model. In this case, shadow prices point to metabolites that should rise or drop in concentration in order to increase consistency between flux predictions and gene expression data. In general, these results suggest that the sensitivity of metabolic optima to violations of the steady state constraints carries biologically significant information on the processes that control intracellular metabolites in the cell.
Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease

The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors together with the discovery of their endogenous ligands in the late 80s and early 90s, resulted in a major effort aimed at understanding the mechanisms and physiological roles of the endocannabinoid system (ECS). Due to its expression and localization in the central nervous system (CNS), the CB1 receptor together with its endogenous ligands (endocannabinoids (eCB)) and the enzymes involved in their synthesis and degradation, has been implicated in multiple pathophysiological events ranging from memory deficits to neurodegenerative disorders among others. In this review, we will provide a general overview of the ECS with emphasis on the CB1 receptor in health and disease. We will describe our current understanding of the complex aspects of receptor signaling and trafficking, including the non-canonical signaling pathways such as those mediated by β-arrestins within the context of functional selectivity and ligand bias. Finally, we will highlight some of the disorders in which CB1 receptors have been implicated. Significant knowledge has been achieved over the last 30 years. However, much more research is still needed to fully understand the complex roles of the ECS, particularly in vivo and to unlock its true potential as a source of therapeutic targets.
Performance Optimization of All-Terrain Robots: A 2D Quasi-Static Tool

The creation of a rover for a specific task requires designing and selecting the mechanical structure specifically for its mission. This can be done by modelling a chassis and evaluating it with specific criteria, which is the aim of the performance optimization tool presented here. This software makes it possible to compare and improve existing and new designs in a quick and efficient way. The tool presented in this paper is based on a quasi-static approach including optimization of the friction coefficients to model and evaluate the rover
The Battle of the Sexes over Seed Size: Support for Both Kinship Genomic Imprinting and Interlocus Contest Evolution

Outcrossing creates a venue for parental conflict. When one sex provides parental care to offspring fertilized by several partners, the nonproviding sex is under selection to maximally exploit the caring sex. The caring sex may counteradapt, and a coevolutionary arms race ensues. Genetic models of this conflict include the kinship theory of genomic imprinting (parent-of-origin-specific expression of maternal-care effectors) and interlocus conflict evolution (interaction between male selfish signals and female abatement). Predictions were tested by measuring the sizes of seeds produced by within-population crosses (diallel design) and between-population crosses in outcrossing and selfing populations of Arabidopsis lyrata. Within-population diallel crosses revealed substantial maternal variance in seed size in most populations. The comparison of between- and within-population crosses showed that seeds were larger when pollen came from another outcrossing population than when pollen came from a selfing or the same population, supporting interlocus contest evolution between male selfish genes and female recognition genes. Evidence for kinship genomic imprinting came from complementary trait means of seed size in reciprocal between-population crosses independent of whether populations were predominantly selfing or outcrossing. Hence, both kinship genomic imprinting and interlocus contest are supported in outcrossing Arabidopsis, whereas only kinship genomic imprinting is important in selfing populations.
A super cut-off CMOS (SCCMOS) scheme for 0.5-V supply voltage with picoampere stand-by current

A super cut-off CMOS (SCCMOS) scheme is proposed and demonstrated by measurement to achieve high-speed and low stand-by current CMOS VLSIs in sub-1-V supply voltage regime. By overdriving the gate of a cut-off MOSFET, the SCCMOS suppresses leakage current below 1 pA per logic gate in a stand-by mode while high-speed operation in an active mode is possible with low-threshold voltage of 0.1-0.2 V. The SCCMOS pushes the low-voltage operation limit 0.2 V further down compared with conventional schemes while maintaining the same stand-by current level.
DESCRIPTION OF A NEW EIMERIA SP. AND ASSOCIATED LESIONS IN THE KIDNEYS OF DOUBLE-CRESTED CORMORANTS (PHALOCROCORAX AURITUS)

A new Eimeria sp. is described as the cause of an outbreak of renal coccidiosis in double-crested cormorants (Phalacrocorax auritus) in Georgia. Sporulated oocysts were spherical to subspherical and measured 16.1 × 16.5 (13.8–18 × 14–19) μm, with an average length–width ratio of 1:1. Oocyst wall was thin (1 μm), greenish, and pitted on the outer surface. Micropyle, micropylar cap, Stieda body, and polar bodies were absent. Small oocyst residuum (4–8 granules) was usually absent but occasionally present. Sporocysts were oval and measured 6.6 × 9.3 (6–7 × 8–10.5) μm, with an average length–width ratio of 1:1.4. A sporocyst residuum was present, located in between sporozoites, and was composed of numerous granules of unequal size. A small refractile body was present in each sporozoite. Collecting duct and distal renal tubular epithelial cells were distended by large oocysts in their cytoplasm, and many oocysts were present in the lumen of dilated tubules. Various stages of meronts, gamonts, and developing oocysts were present in other renal tubular epithelial cells. Multiple infections of parasitized cells were frequently observed, with cells containing up to 12 gamonts or developing oocysts. The importance of this Eimeria sp. on double-crested cormorant populations is not known. But in this case, significant lesions and mortality were associated with infection.
Ten year secular declines in the cardiorespiratory fitness of affluent English children are largely independent of changes in body mass index

Secular changes in body mass index (BMI) and cardiorespiratory fitness (20 m shuttle-run test performance) were assessed in 10-year-old children from an affluent area of England in 1998 (n = 303; 158 boys and 145 girls) and 2008 (n = 315; 158 boys and 157 girls). Girls’ BMI did not change over the 10 year period. There was a significant increase in boys’ BMI (p = 0.02). Cardiorespiratory fitness declined significantly (p<0.001) in both boys (7%) and girls (9%). This study shows a large and worrying decline in cardiorespiratory fitness in children from an affluent area of England.
Poselet Key-Framing: A Model for Human Activity Recognition

In this paper, we develop a new model for recognizing human actions. An action is modeled as a very sparse sequence of temporally local discriminative key frames - collections of partial key-poses of the actor(s), depicting key states in the action sequence. We cast the learning of key frames in a max-margin discriminative framework, where we treat key frames as latent variables. This allows us to (jointly) learn a set of most discriminative key frames while also learning the local temporal context between them. Key frames are encoded using a spatially-localizable pose let-like representation with HoG and BoW components learned from weak annotations, we rely on structured SVM formulation to align our components and mine for hard negatives to boost localization performance. This results in a model that supports spatio-temporal localization and is insensitive to dropped frames or partial observations. We show classification performance that is competitive with the state of the art on the benchmark UT-Interaction dataset and illustrate that our model outperforms prior methods in an on-line streaming setting.
The Theory of Localist Representation and of a Purely Abstract Cognitive System: The Evidence from Cortical Columns, Category Cells, and Multisensory Neurons

The debate about representation in the brain and the nature of the cognitive system has been going on for decades now. This paper examines the neurophysiological evidence, primarily from single cell recordings, to get a better perspective on both the issues. After an initial review of some basic concepts, the paper reviews the data from single cell recordings – in cortical columns and of category-selective and multisensory neurons. In neuroscience, columns in the neocortex (cortical columns) are understood to be a basic functional/computational unit. The paper reviews the fundamental discoveries about the columnar organization and finds that it reveals a massively parallel search mechanism. This columnar organization could be the most extensive neurophysiological evidence for the widespread use of localist representation in the brain. The paper also reviews studies of category-selective cells. The evidence for category-selective cells reveals that localist representation is also used to encode complex abstract concepts at the highest levels of processing in the brain. A third major issue is the nature of the cognitive system in the brain and whether there is a form that is purely abstract and encoded by single cells. To provide evidence for a single-cell based purely abstract cognitive system, the paper reviews some of the findings related to multisensory cells. It appears that there is widespread usage of multisensory cells in the brain in the same areas where sensory processing takes place. Plus there is evidence for abstract modality invariant cells at higher levels of cortical processing. Overall, that reveals the existence of a purely abstract cognitive system in the brain. The paper also argues that since there is no evidence for dense distributed representation and since sparse representation is actually used to encode memories, there is actually no evidence for distributed representation in the brain. Overall, it appears that, at an abstract level, the brain is a massively parallel, distributed computing system that is symbolic. The paper also explains how grounded cognition and other theories of the brain are fully compatible with localist representation and a purely abstract cognitive system.
Self-Training for Enhancement and Domain Adaptation of Statistical Parsers Trained on Small Datasets

Creating large amounts of annotated data to train statistical PCFG parsers is expensive, and the performance of such parsers declines when training and test data are taken from different domains. In this paper we use selftraining in order to improve the quality of a parser and to adapt it to a different domain, using only small amounts of manually annotated seed data. We report significant improvement both when the seed and test data are in the same domain and in the outof-domain adaptation scenario. In particular, we achieve 50% reduction in annotation cost for the in-domain case, yielding an improvement of 66% over previous work, and a 20-33% reduction for the domain adaptation case. This is the first time that self-training with small labeled datasets is applied successfully to these tasks. We were also able to formulate a characterization of when selftraining is valuable.
The relationship between lactation and the release of prolactin and growth hormone in the goat.

The ability of pituitary hormones to cause udder growth and to initiate milk secretion in the goat was clearly demonstrated when it was shown that both mammary growth and lactation were induced in the ovariectomized virgin goat by twice-daily application of the milking stimulus (Cowie, Knaggs, Tindal & Turvey, 1968). It was further demonstrated that both of these responses were completely abolished in animals in which the pituitary stalk was transected before 'milking' was started. As earlier work had shown that suckling often resulted in a fall in pituitary hormone concentration (see Cowie & Tindal, 1971) it seemed probable that both mammary growth and lactation were initiated by elevated blood levels of pituitary hormones. Concerning the maintenance of milk secretion, partly successful hormonal replacement studies in the hypophysectomized lactating goat were first described by Cowie & Tindal (1961) followed by Gale & Larson (1963). Complete restoration and maintenance of the milk yield was subsequently achieved with a combination of ovine prolactin, bovine GH, tri-iodothyronine, protamine zinc insulin and dexamethasone (Cowie, Knaggs & Tindal, 1964). The presence of prolactin was important for the restoration of the milk yield to the pre-hypophysectomy level but it was not always necessary for the maintenance of lactation at that level (Cowie, 1969). The anterior pituitary hormones prolactin and GH would thus appear to play an essential rôle in the establishment and maintenance of lactation in the goat. Using radioimmunoassays for ovine/caprine prolactin (Hart, and caprine GH (I. C. Hart, S. Andrews A. S. McNeilly, in preparation), it has now been possible to measure the circulating levels of these hormones under a variety of conditions in the goat and thereby attempt