Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive training of self-initiation of semantic encoding strategies in schizophrenia: A pilot study

Available cognitive remediation interventions have a significant but relatively small to moderate impact on episodic memory in schizophrenia. The present study aimed to evaluate the efficacy and feasibility of a brief novel episodic memory training targeting the self-initiation of semantic encoding strategies. To select patients with such deficits, 28 participants with schizophrenia performed our Semantic Encoding Memory Task (SEMT) that provides a measure of self-initiated semantic encoding strategies. This task identified a deficit in 13 participants who were then offered two 60-minute training sessions one week apart. After the training, patients performed an alternate version of the SEMT. The CVLT-II (a standardised measure of semantic encoding strategies) and the BVMT-R (a control spatial memory task) were used to quantify memory pre- and post-training. After the training, participants were significantly better at self-initiating semantic encoding strategies in the SEMT (p = .004) and in the CVLT-II (p = .002). No significant differences were found in the BVMT-R. The current study demonstrates that a brief and specific training in memory strategies can help patients to improve a deficient memory process in schizophrenia. Future studies will need to test this intervention further using a randomised controlled trial, and to explore its functional impact.
Physical Activity Measured by Accelerometry and its Associations With Cardiac Structure and Vascular Function in Young and Middle‐Aged Adults

Background Physical activity is associated with several health benefits, including lower cardiovascular disease risk. The independent influence of physical activity on cardiac and vascular function in the community, however, has been sparsely investigated. Measures and Results We related objective measures of moderate‐ to vigorous‐intensity physical activity (MVPA, assessed by accelerometry) to cardiac and vascular indices in 2376 participants of the Framingham Heart Study third generation cohort (54% women, mean age 47 years). Using multivariable regression models, we related MVPA to the following echocardiographic and vascular measures: left ventricular mass, left atrial and aortic root sizes, carotid–femoral pulse wave velocity, augmentation index, and forward pressure wave. Men and women engaged in MVPA 29.9±21.4 and 25.5±19.4 min/day, respectively. Higher values of MVPA (per 10‐minute increment) were associated with lower carotid–femoral pulse wave velocity (estimate −0.53 ms/m; P=0.006) and lower forward pressure wave (estimate −0.23 mm Hg; P=0.03) but were not associated with augmentation index (estimate 0.13%; P=0.25). MVPA was associated positively with loge left ventricular mass (estimate 0.006 loge [g/m2]; P=0.0003), left ventricular wall thickness (estimate 0.07 mm; P=0.0001), and left atrial dimension (estimate 0.10 mm; P=0.01). MVPA also tended to be positively associated with aortic root dimension (estimate 0.05 mm; P=0.052). Associations of MVPA with cardiovascular measures were similar, in general, for bouts lasting <10 versus ≥10 minutes. Conclusions In our community‐based sample, greater physical activity was associated with lower vascular stiffness but with higher echocardiographic left ventricular mass and left atrial size. These findings suggest complex relations of usual levels of physical activity and cardiovascular remodeling.
Predictors of persistent methicillin-resistant Staphylococcus aureus bacteraemia in patients treated with vancomycin.

OBJECTIVES The high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) coupled with an increase in vancomycin use have induced vancomycin tolerance in MRSA, adversely affecting the outcome of MRSA bacteraemia. This study aimed to identify predictors of persistent MRSA bacteraemia (PMRSAB) in patients treated with vancomycin. METHODS A retrospective, case-control study was performed at a university hospital in Korea from January 2006 to February 2009. Subjects included 96 patients who had MRSA bacteraemia and received vancomycin under therapeutic drug monitoring. We compared the clinical characteristics, management and outcomes of cases with PMRSAB (>or=7 days, n = 31) with controls with non-PMRSAB (<or=3 days, n = 32). Vancomycin MICs were determined by the Vitek 2 system. RESULTS Of 96 patients with MRSA bacteraemia, MRSA isolates from 21 patients (21.9%) showed a vancomycin MIC of 2 mg/L. Independent predictors of PMRSAB were: retention of implicated medical devices [odds ratio (OR), 10.35; 95% confidence interval (CI), 1.03-104.55]; MRSA infection of at least two sites (OR, 10.24; 95% CI, 1.72-61.01); and vancomycin MIC of 2 mg/L (OR, 6.34; 95% CI, 1.21-33.09). The frequency of side effects and mean trough serum vancomycin concentrations were not significantly different between the two groups. Sixteen patients with PMRSAB subsequently received teicoplanin +/- arbekacin, linezolid or quinupristin/dalfopristin, due to vancomycin failure or intolerance. CONCLUSIONS To minimize the risk of PMRSAB, early removal of implicated devices and evaluation for metastatic infections should be encouraged. Alternative antibiotic therapy is warranted for infections due to isolates with elevated vancomycin MICs, as well as for the high rates of side effects.
The Association between Alcohol Consumption Patterns and Health-Related Quality of Life in a Nationally Representative Sample of South Korean Adults

This study examined the relationship between alcohol consumption and health-related quality of life (HRQOL) in a nationally representative sample of middle-aged to older South Koreans. Data collected from 3,408 men and 3,361 women aged ≥ 40 years were obtained from the 2010 and 2011 Korea National Health and Nutrition Examination Survey. Based on the World Health Organization guidelines, the participants were categorized into zones I (0–7), II (8–15), III (16–19), or IV (20–40) according to their Alcohol Use Disorders Identification Test (AUDIT) scores, with a higher zone indicating a higher level of alcohol consumption. Data collected from the AUDIT and EuroQol 5-Dimension (EQ-5D) test were subjected to multiple regression analysis in order to examine the relationship between alcohol consumption patterns and health-related quality of life, and to identify intersex and interzone differences. Significant intersex differences were found for the mean total AUDIT and EQ-5D scores and the proportion of participants rating their pain/discomfort and impairment in mobility and usual activities as “moderate” or “severe” (p < 0.001). The analysis of the EQ-5D scores by alcohol consumption pattern and sex suggested the existence of an inverted U-shaped relationship between the total AUDIT and EQ-5D scores. The HRQOL of moderate alcohol drinkers was higher than that of non-drinkers and heavy drinkers. The results of this study will be valuable in designing appropriate interventions to increase the HRQOL impaired by the harmful use of alcohol, in comparing HRQOL among different countries, and in implementing alcohol-related health projects.
Caveolin 1 Modulates Aldosterone‐Mediated Pathways of Glucose and Lipid Homeostasis

Background Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav‐1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav‐1 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav‐1–null mice and humans with a prevalent variant in the CAV1 gene. Methods and Results In mouse studies, cav‐1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high‐ to low‐density lipoprotein (all P<0.001 versus wild type). Moreover, cav‐1 knockout mice displayed hypertriglyceridemia and higher mRNA levels for resistin, retinol binding protein 4, NADPH oxidase 4, and aldose reductase in liver and/or fat tissues. MR blockade with eplerenone significantly decreased glycemia (P<0.01), total cholesterol (P<0.05), resistin (P<0.05), and described enzymes, with no effect on insulin or triglycerides. In the human study, we analyzed the CAV1 gene polymorphism rs926198 in 556 white participants; 58% were minor allele carriers and displayed higher odds of insulin resistance (odds ratio 2.26 [95% CI 1.40–3.64]) and low high‐density lipoprotein (odds ratio 1.54 [95% CI 1.01–3.37]). Aldosterone levels correlated with higher homeostatic model assessment of insulin resistance and resistin and lower high‐density lipoprotein only in minor allele carriers. CAV1 gene expression quantitative trait loci data revealed lower cav‐1 expression in adipose tissues by the rs926198 minor allele. Conclusions Our findings in mice and humans suggested that decreased cav‐1 expression may activate the effect of aldosterone/MR signaling on several pathways of glycemia, dyslipidemia, and resistin. In contrast, hyperinsulinemia and hypertriglyceridemia are likely mediated by MR‐independent mechanisms. Future human studies will elucidate the clinical relevance of MR blockade in patients with genotype‐mediated cav‐1 deficiency.
Wettability of smooth and rough surfaces of perfluoroacrylate copolymers

In this study, it was primarily shown that random copolymers of perfluoroacrylates can have sufficient hydrophobicity to be effectively employed for the production of ultrahydrophobic surfaces via electrospinning. Presence of small molar amounts of perfluoroacrylate in the copolymer chain resulted in the formation of rather hydrophobic copolymers surfaces that had lower surface free energy than poly(tetrafluoroethylene) due to the orientation of fluorinated groups to the solid-vapor interface on the outermost surface layer. The surface energy measurements of the copolymers indicated that amphiphilic copolymers may have lower surface free energy than the copolymers of perfluoroacrylates with non-polar monomers due to the higher excess of the fluorinated groups on the surface. However, it was also shown for the ultrahydrophobic surfaces of amphiphilic copolymers that reorientation of polar groups to the solid-liquid interface due to water contact on the protrusion tops, where the long interval solid-liquid contact took place, can increase the threshold water sliding angle on the surface remarkably while the high advancing contact angles were maintained for long days. The former was detected to be a direct result of the enhanced adhesive bonds between the three phase contact line and the tops of the solid protrusions, which prevented the receding of the drops; while the latter was attributed to the preserved composite surface structure by the inability of water in penetrating through the hydrophobic walls of the cavities. Consequently, ultrahydrophobicity was lost while superhydrophobic character was preserved. This result one more time showed that high advancing contact angle values do not indicate water repellence all the time. Due to the stability of the styrene-perfluoroacrylate copolymer surface against water exposure, this polymer was chosen to study for further improvements such as enhancing the ultrahydrophobic character. Experiments showed that the effect of applied voltage in electrospinning on the water repellence of surfaces electrospun at low solution concentrations is remarkable. By increasing the applied voltage to high values, a surface on which the microtopology was composed of nanometric beads covering the micron level roughness everywhere was produced. The resultant surface showed no contact angle hysteresis and was perfectly non-wetting, and exhibited no adhesion with water while a pendant drop was made to touch and retreat from the surface.
A Fault Tolerant Efficient Scheduling Method for Improved Network Delay in Distributed Sensor Networks

Wireless s ensor networks are now applied in many fields which deal w ith data - centric information or critical mission th at need minimized network delay. At same time, it needs the capability of dealing with faulty situations . In this work, we propose scalable network architecture and an operating mechanism that in nature is tolerant to network structure change caused by fai lure, and extend our application level scheduling algorithm with the capability of heal ing from the failure. The algorithm achieves optimized network delay and get s close form solution that is computational simple to implement. We also look into the signif icance of different nodes' failure in both homogeneous and heterogeneous sensor network. Simulation results imply the effect s of sensing and communication speed on significance of failure in he terogeneous sensor networks .
Friction and output backlash compensation of systems using neural network and fuzzy logic

A friction and output backlash compensator is designed for systems by the fuzzy logic (FL) and the neural network (NN). The classification property of FL system and the function approximation ability of the NN make them the natural candidate for the rejection of errors induced by the friction and output backlash. The tuning algorithms are given for the fuzzy logic parameters and the NN weights, so that the friction and output backlash compensation scheme becomes adaptive, guaranteeing small tracking errors and bounded parameter estimates. Formal nonlinear stability proofs are given to show that the tracking error is small. The NN friction and FL output backlash compensator is simulated on a system to show its efficacy.
Efficient Metabolic Exchange and Electron Transfer within a Syntrophic Trichloroethene-Degrading Coculture of Dehalococcoides mccartyi 195 and Syntrophomonas wolfei

ABSTRACT Dehalococcoides mccartyi 195 (strain 195) and Syntrophomonas wolfei were grown in a sustainable syntrophic coculture using butyrate as an electron donor and carbon source and trichloroethene (TCE) as an electron acceptor. The maximum dechlorination rate (9.9 ± 0.1 μmol day−1) and cell yield [(1.1 ± 0.3) × 108 cells μmol−1 Cl−] of strain 195 maintained in coculture were, respectively, 2.6 and 1.6 times higher than those measured in the pure culture. The strain 195 cell concentration was about 16 times higher than that of S. wolfei in the coculture. Aqueous H2 concentrations ranged from 24 to 180 nM during dechlorination and increased to 350 ± 20 nM when TCE was depleted, resulting in cessation of butyrate fermentation by S. wolfei with a theoretical Gibbs free energy of −13.7 ± 0.2 kJ mol−1. Carbon monoxide in the coculture was around 0.06 μmol per bottle, which was lower than that observed for strain 195 in isolation. The minimum H2 threshold value for TCE dechlorination by strain 195 in the coculture was 0.6 ± 0.1 nM. Cell aggregates during syntrophic growth were observed by scanning electron microscopy. The interspecies distances to achieve H2 fluxes required to support the measured dechlorination rates were predicted using Fick's law and demonstrated the need for aggregation. Filamentous appendages and extracellular polymeric substance (EPS)-like structures were present in the intercellular spaces. The transcriptome of strain 195 during exponential growth in the coculture indicated increased ATP-binding cassette transporter activities compared to the pure culture, while the membrane-bound energy metabolism related genes were expressed at stable levels.
Nanoscale characterization of the biomechanical hardening of bovine zona pellucida

The zona pellucida (ZP) is an extracellular membrane surrounding mammalian oocytes. The so-called zona hardening plays a key role in fertilization process, as it blocks polyspermy, which may also be caused by an increase in the mechanical stiffness of the ZP membrane. However, structural reorganization mechanisms leading to ZP's biomechanical hardening are not fully understood yet. Furthermore, a correct estimate of the elastic properties of the ZP is still lacking. Therefore, the aim of the present study was to investigate the biomechanical behaviour of ZP membranes extracted from mature and fertilized bovine oocytes to better understand the mechanisms involved in the structural reorganization of the ZP that may lead to the biomechanical hardening of the ZP. For that purpose, a hybrid procedure is developed by combining atomic force microscopy nanoindentation measurements, nonlinear finite element analysis and nonlinear optimization. The proposed approach allows us to determine the biomechanical properties of the ZP more realistically than the classical analysis based on Hertz's contact theory, as it accounts for the nonlinearity of finite indentation process, hyperelastic behaviour and material heterogeneity. Experimental results show the presence of significant biomechanical hardening induced by the fertilization process. By comparing various hyperelastic constitutive models, it is found that the Arruda–Boyce eight-chain model best describes the biomechanical response of the ZP. Fertilization leads to an increase in the degree of heterogeneity of membrane elastic properties. The Young modulus changes sharply within a superficial layer whose thickness is related to the characteristic distance between cross-links in the ZP filamentous network. These findings support the hypothesis that biomechanical hardening of bovine ZP is caused by an increase in the number of inter-filaments cross-links whose density should be higher in the ZP inner side.
Towards Statistical Guarantees in Controlling Quality Tradeoffs for Approximate Acceleration

Conventionally, an approximate accelerator replaces every invocation of a frequently executed region of code without considering the final quality degradation. However, there is a vast decision space in which each invocation can either be delegated to the accelerator-improving performance and efficiency-or run on the precise core-maintaining quality. In this paper we introduce MITHRA, a co-designed hardware-software solution, that navigates these tradeoffs to deliver high performance and efficiency while lowering the final quality loss. MITHRA seeks to identify whether each individual accelerator invocation will lead to an undesirable quality loss and, if so, directs the processor to run the original precise code. This identification is cast as a binary classification task that requires a cohesive co-design of hardware and software. The hardware component performs the classification at runtime and exposes a knob to the software mechanism to control quality tradeoffs. The software tunes this knob by solving a statistical optimization problem that maximizes benefits from approximation while providing statistical guarantees that final quality level will be met with high confidence. The software uses this knob to tune and train the hardware classifiers. We devise two distinct hardware classifiers, one table-based and one neural network based. To understand the efficacy of these mechanisms, we compare them with an ideal, but infeasible design, the oracle. Results show that, with 95% confidence the table-based design can restrict the final output quality loss to 5% for 90% of unseen input sets while providing 2.5× speedup and 2.6× energy efficiency. The neural design shows similar speedup however, improves the efficiency by 13%. Compared to the table-based design, the oracle improves speedup by 26% and efficiency by 36%. These results show that MITHRA performs within a close range of the oracle and can effectively navigate the quality tradeoffs in approximate acceleration.
Prevalence of Combined Somatic and Mental Health Multimorbidity: Patterns by Age, Sex, and Race/Ethnicity.

BACKGROUND The coexistence of chronic mental health conditions with somatic conditions (somatic-mental multimorbidity, or SMM) is common and has been associated with greater symptom burden and functional impairment, higher costs, and excess mortality. However, most existing literature focused on the co-occurrence of an index mental health condition with specific additional conditions. By contrast, we studied the prevalence and patterns of SMM more broadly considering 19 selected conditions, and we focused on differences by age, sex, and race/ethnicity. METHODS The Rochester Epidemiology Project (REP) records-linkage system was used to identify all residents of Olmsted County, MN, on April 1, 2010. We identified individuals with each of 19 common chronic conditions, including 5 mental health conditions, using the International Classification of Diseases, ninth revision (ICD-9) codes received from any health care provider between April 1, 2005 and March 31, 2010. RESULTS Among the 138,858 residents of the county, 52.4% were women, and 7.9% had SMM. SMM increased steeply with older age, was 1.7 times more common in women, and was lower in Asians compared with whites. Of the 10,903 persons with SMM, 7,739 (71.0%) were younger than 65 years. Depressive and anxiety disorders were the most common conditions involved in SMM. The dyads that were observed more frequently or less frequently than expected by chance varied in composition by age and sex. CONCLUSIONS SMM that reaches medical attention is highly prevalent across all age groups, is more frequent in women, is less frequent in Asians, and encompasses a wide range of conditions.
Research Report - The Relevance of Application Domain Knowledge: The Case of Computer Program Comprehension

The field of software, has, to date, focused almost exclusively on application-independent approaches. In this research, we demonstrate the role of application domain knowledge in the processes used to comprehend computer programs. Our research sought to reconcile two apparently conflicting theories of computer program comprehension by proposing a key role for knowledge of the application domain under examination. We argue that programmers use more top-down comprehension processes when they are familiar with the application domain. When the application domain is unfamiliar, programmers use processes that are more bottom-up in nature. We conducted a protocol analysis study of 24 professional programmers comprehending programs in familiar and unfamiliar application domains. Our findings confirm our thesis.