Miracle-dz/UniFAR-FTUs huggingface dataset:
A Survey of Women and Their Providers Regarding Gestational Weight Gain.

Background: Inappropriate gestational weight gain (GWG) is prevalent in the United States. About 20% of women gain below Institute of Medicine (IOM) recommendations; more than 50% gain above. GWG outside of recommendations is linked to poor birth outcomes and health issues for mother and baby. Counseling by health care providers is important to encourage appropriate GWG. Objective: Assess patient recall of counseling regarding GWG, provider knowledge, and opinions about IOM GWG guidance, and GWG outcomes in a subset of women. Study Design: Cross-sectional, with questionnaires distributed by 8 medical centers across the United States to patients. Questionnaires were distributed to providers and data on maternal body mass index (BMI) and GWG collected at seven sites. Results: A total of 1,157 women returned questionnaires (1,820 maximum possible). A majority at all sites reported a provider discussed their expected GWG with them. Close to half reported that a provider had discussed potential harms from inappropriate GWG. Most of the women (71.2%) considered their obstetrician to be a helpful resource for GWG advice. Most providers (87.5%) reported they were aware of IOM guidelines. As many providers disagreed (18.8%) as agreed (20.8%) that they were successful helping their patients attain appropriate GWG (58.3% were neutral). Physician self-reported confidence was associated with whether they believed they could help their patients avoid excessive GWG. The most common outcome was GWG above recommendations (51.4%). Overweight and obese women were more likely to gain above recommendations. Providers underestimated the proportion of their patients that gained below IOM recommendations (8.5% vs. 18.6%). Conclusions: Providers are aware of the dangers of excessive GWG and a majority of patients report receiving counseling. Providers appear more cognizant of excessive GWG and underestimate inadequate GWG. Most women are not achieving an appropriate GWG, with overweight and obese women especially likely to gain above recommendations.
The Emergence of Conventions in Online Social Networks

The way in which social conventions emerge in communities has been of interest to social scientists for decades. Here we report on the emergence of a particular social convention on Twitter—the way to indicate a tweet is being reposted and to attribute the content to its source. Initially, different variations were invented and spread through the Twitter network. The inventors and early adopters were well-connected, active, core members of the Twitter community. The diffusion networks of these conventions were dense and highly clustered, so no single user was critical to the adoption of the conventions. Despite being invented at different times and having different adoption rates, only two variations came to be widely adopted. In this paper we describe this process in detail, highlighting insights and raising questions about how social conventions emerge.
Calcineurin-Responsive Zinc Finger Transcription Factor CRZ1 of Botrytis cinerea Is Required for Growth, Development, and Full Virulence on Bean Plants

ABSTRACT Recently, we showed that the α subunit BCG1 of a heterotrimeric G protein is an upstream activator of the Ca2+/calmodulin-dependent phosphatase calcineurin in the gray mold fungus Botrytis cinerea. To identify the transcription factor acting downstream of BCG1 and calcineurin, we cloned the gene encoding the B. cinerea homologue of CRZ1 (“CRaZy,” calcineurin-responsive zinc finger transcription factor), the mediator of calcineurin function in yeast. BcCRZ1 is able to partially complement the corresponding Saccharomyces cerevisiae mutant, and the subcellular localization of the green fluorescent protein-BcCRZ1 fusion product in yeast cells depends on the calcium level and calcineurin activity. Bccrz1 deletion mutants are not able to grow on minimal media and grow slowly on media containing plant extracts. Hyphal morphology, conidiation, and sclerotium formation are impaired. The cell wall and membrane integrity, stress response (extreme pH, H2O2, Ca2+, Li+), and ability of the hyphae to penetrate the intact plant surface are affected in the mutants. However, BcCRZ1 is almost dispensable for the conidium-derived infection of bean plants. The addition of Mg2+ restores the growth rate, conidiation, and penetration and improves the cell wall integrity but has no impact on sclerotium formation or hypersensitivity to Ca2+ and H2O2. The expression of a set of recently identified BCG1- and calcineurin-dependent genes is also affected in ΔBccrz1 mutants, confirming that this transcription factor acts downstream of calcineurin in B. cinerea. Since the Bccrz1 mutants still respond to calcineurin inhibitors, we conclude that BcCRZ1 is not the only target of calcineurin.
What Can We Learn about Neighborhood Effects from the Moving to Opportunity Experiment?1

Experimental estimates from Moving to Opportunity (MTO) show no significant impacts of moves to lower‐poverty neighborhoods on adult economic self‐sufficiency four to seven years after random assignment. The authors disagree with Clampet‐Lundquist and Massey's claim that MTO was a weak intervention and therefore uninformative about neighborhood effects. MTO produced large changes in neighborhood environments that improved adult mental health and many outcomes for young females. Clampet‐Lundquist and Massey's claim that MTO experimental estimates are plagued by selection bias is erroneous. Their new nonexperimental estimates are uninformative because they add back the selection problems that MTO's experimental design was intended to overcome.
Accuracy and Precision of Desktop Spirometers in General Practices

Background: Spirometry has become an essential tool for general practices to diagnose and monitor chronic airways diseases, but very little is known about the performance of the spirometry equipment that is being used in general practice settings. The use of invalid spirometry equipment may have consequences on disease diagnosis and management of patients. Objectives: To establish the accuracy and precision of desktop spirometers that are routinely used in general practices. Methods: We evaluated a random sample of 50 spirometers from Dutch general practices by testing them on a certified waveform generator using 8 standard American Thoracic Society waveforms to determine accuracy and precision. Details about the brand and type of spirometers, year of purchase, frequency of use, cleaning and calibration were inquired with a study-specific questionnaire. Results: 39 devices (80%) were turbine spirometers, 8 (16%) were pneumotachographs, and 1 (2%) was a volume displacement spirometer. Mean age of the spirometers was 4.3 (SD 3.7) years. Average deviation from the waveform generator reference values (accuracy) was 25 ml (95% confidence interval 12–39 ml) for FEV1 and 27 ml (10–45 ml) for FVC, but some devices showed substantial deviations. FEV1 deviations were larger for pneumotachographs than for turbine spirometers (p < 0.0031), but FVC deviations did not differ between the two types of spirometers. In the subset of turbine spirometers, no association between age and device performance was observed. Conclusions: On average, desktop spirometers in general practices slightly overestimated FEV1 and FVC values, but some devices showed substantial deviations. General practices should pay more attention to the calibration of their spirometer.
International Journal of Nanomedicine Dovepress Antibacterial Activity and Cytotoxicity of Multi-walled Carbon Nanotubes Decorated with Silver Nanoparticles

Recently, various nanoscale materials, including silver (Ag) nanoparticles, have been actively studied for their capacity to effectively prevent bacterial growth. A critical challenge is to enhance the antibacterial properties of nanomaterials while maintaining their biocompatibility. The conjugation of multiple nanomaterials with different dimensions, such as spherical nanoparticles and high-aspect-ratio nanotubes, may increase the target-specific antibacterial capacity of the consequent nanostructure while retaining an optimal biocompat-ibility. In this study, multi-walled carbon nanotubes (MWCNTs) were treated with a mixture of acids and decorated with Ag nanoparticles via a chemical reduction of Ag cations by ethanol solution. The synthesized Ag-MWCNT complexes were characterized by transmission electron microscopy, X-ray diffractometry, and energy-dispersive X-ray spectroscopy. The antibacterial function of Ag-MWCNTs was evaluated against Methylobacterium spp. and Sphingomonas spp. In addition, the biocompatibility of Ag-MWCNTs was evaluated using both mouse liver hepatocytes (AML 12) and human peripheral blood mononuclear cells. Finally, we determined the minimum amount of Ag-MWCNTs required for a biocompatible yet effective antibacterial treatment modality. We report that 30 μg/mL of Ag-MWCNTs confers antibacterial function-ality while maintaining minimal cytotoxicity toward both human and animal cells. The results reported herein would be beneficial for researchers interested in the efficient preparation of hybrid nanostructures and in determining the minimum amount of Ag-MWCNTs necessary to effectively hinder the growth of bacteria.
Lupus anticoagulant and venous leg ulceration

Summary Background Most leg ulcers occur in patients with venous insufficiency. However, not all patients with venous insufficiency develop leg ulcers. Recent studies have found that factors causing clotting abnormalities, e.g. anticardiolipin antibody (ACA), are associated with leg ulcers. Although lupus anticoagulant, like ACA, belongs to the group of antiphospholipid antibodies, its presence in patients with venous leg ulceration has not been previously reported.
Comparing Single , Dual and Quad-Polarimetric Data at L-band for Classification Purposes in Eastern Amazon

Single, dual, and quad-polarization mode data at spaceborne L-band were evaluated for the classification of seven land use classes in an area with shifting cultivation practices located in the Eastern Amazon (Brazil). We evaluated Advanced Land-Observing Satellite (ALOS) Phased Array L-band Synthetic Aperture Radar (PALSAR) derived backscattering intensity, polarimetric features, interferometric coherence and texture parameters for classification purposes using support vector machines (SVM) and feature selection. Results showed that the forest classes were characterized by low temporal backscattering intensity variability, low coherence and high entropy. Quad polarization mode performed better than dual and single polarizations but overall accuracies remain low and were affected by precipitation events on the date and prior SAR date acquisition. Misclassifications were reduced by integrating Landsat data and an overall accuracy of 85% was attained. We show that in absence of Landsat data, polarimetric features extracted from quad-polarization Lband increase classification accuracies when compared to single and dual polarization alone. We argue that the joint analysis of SAR and their derived parameters with optical data performs even better and thus encourage the further development of joint techniques. Key-words: land use, ALOS/PALSAR, successional forest stages, SVM, polarimetry.
Psychometric Properties of an Instrument to Assess Medicare Beneficiaries' Prescription Drug Plan Experiences

Using data from 335,249 Medicare beneficiaries who responded to the 2007 Medicare Consumer Assessment of Healthcare Providers and Systems (CAHPS®) survey, along with data from 22 cognitive interviews, we investigated the reliability and validity of an instrument designed to assess beneficiaries' experiences with their prescription drug plans. Composite measures derived from the instrument had acceptable internal consistency and sufficient plan-level reliability to inform consumer choice, quality improvement, and payor oversight. These measures were positively associated with members' overall rating of the plan and their willingness to recommend the plan. Moreover, each was independently useful in predicting beneficiaries' global ratings of their plan. This instrument can be an important tool for helping beneficiaries to choose a plan that best meets their needs.
Toxic and growth retarding effects of three plant extracts on Culex pipiens larvae (Diptera: Culicidae)

The toxic and/or development retarding effects on Culex pipiens mosquito larvae by methanol and ether extracts of Azadirachta indica, Rhazya stricta and Syzygium aromaticum were investigated separately. All were found to show biological activity, however, the methanol extracts showed the most profound effects. R. stricta showed marked acute (2 d) and chronic (10 d) toxic effects, having an LC50 and 95% CL of 251(209–326) and 140(110–178); 467(416–699) and 211(198–421) ppm, for the methanol and ether extracts, respectively. Only 3.3% of the larvae pupated and no adults emerged even at the lowest concentration (200 ppm) of methanol extract. Both A. indica extracts were toxic to C. pipiens larvae but at higher concentrations, showing an acute and chronic LC50 and 95% CL of 824(692–980) and 265(111–481); 1620(1380–1892) and 675(514–887) ppm for the methanol and ether extracts, respectively. The methanol extracts of A. indica, at concentrations above 800 ppm, reduced pupation to 3.3% and completely inhibited adult emergence. Both extracts of S. aromaticum were less toxic to the larvae, however their influence on development was remarkable, causing complete inhibition of adult emergence at 200 and 600 ppm concentrations of the methanol and ether extracts, respectively. Future application of these extracts to larval habitats may lead to promising results in mosquito management programmes. Copyright © 1999 John Wiley & Sons, Ltd.
Laser Speckle Imaging of Rat Pial Microvasculature during Hypoperfusion-Reperfusion Damage

The present study was aimed to in vivo assess the blood flow oscillatory patterns in rat pial microvessels during 30 min bilateral common carotid artery occlusion (BCCAO) and 60 min reperfusion by laser speckle imaging (LSI). Pial microcirculation was visualized by fluorescence microscopy. The blood flow oscillations of single microvessels were recorded by LSI; spectral analysis was performed by Wavelet transform. Under baseline conditions, arterioles and venules were characterized by blood flow oscillations in the frequency ranges 0.005–0.0095 Hz, 0.0095–0.021 Hz, 0.021–0.052 Hz, 0.052–0.150 Hz and 0.150–0.500 Hz. Arterioles showed oscillations with the highest spectral density when compared with venules. Moreover, the frequency components in the ranges 0.052–0.150 Hz and 0.150–0.500 were predominant in the arteriolar total power spectrum; while, the frequency component in the range 0.150–0.500 Hz showed the highest spectral density in venules. After 30 min BCCAO, the arteriolar spectral density decreased compared to baseline; moreover, the arteriolar frequency component in the range 0.052–0.150 Hz significantly decreased in percent spectral density, while the frequency component in the range 0.150–0.500 Hz significantly increased in percent spectral density. However, an increase in arteriolar spectral density was detected at 60 min reperfusion compared to BCCAO values; consequently, an increase in percent spectral density of the frequency component in the range 0.052–0.150 Hz was observed, while the percent spectral density of the frequency component in the range 0.150–0.500 Hz significantly decreased. The remaining frequency components did not significantly change during hypoperfusion and reperfusion. The changes in blood flow during hypoperfusion/reperfusion caused tissue damage in the cortex and striatum of all animals. In conclusion, our data demonstrate that the frequency component in the range 0.052–0.150 Hz, related to myogenic activity, was significantly impaired by hypoperfusion and reperfusion, affecting cerebral blood flow distribution and causing tissue damage.
Major Bleeding, Mortality, and Efficacy of Fondaparinux in Venous Thromboembolism Prevention Trials

Background— Bleeding is a strong predictor of death in patients hospitalized for arterial thrombosis who are treated with antithrombotic therapy, but the prognostic importance of bleeding in patients receiving antithrombotic prophylaxis for venous thromboembolism is uncertain. Methods and Results— Using Cox proportional hazards modeling, we examined the association between major bleeding and death at 30 days using pooled individual patient data from 8 large randomized controlled trials (n=13 085) comparing fondaparinux with control (low-molecular-weight heparin or placebo) for the prophylaxis of venous thromboembolism in hospitalized surgical or medical patients. Patients who developed major bleeding were older, were more likely to be male, had a lower body weight and lower creatinine clearance, and were more likely to be receiving fondaparinux. At 30 days, the risk of death was 7-fold higher among patients with a major bleeding event (8.6% versus 1.7%; adjusted hazard ratio, 6.96; 95% confidence interval, 4.60 to 10.51). There was a consistent pattern of reduced mortality in patients treated with fondaparinux irrespective of whether patients experienced major bleeding (6.8% versus 11.4%; hazard ratio, 0.58; 95% confidence interval, 0.27 to 1.23) or no major bleeding (1.5% versus 1.9%; hazard ratio, 0.77; 95% confidence interval, 0.59 to 1.02; P for heterogeneity=0.47). Conclusions— Major bleeding in hospitalized surgical and medical patients participating in venous thromboembolism prevention trials is a strong predictor of mortality.
Hepatoblastoma and low birth weight: a trend or chance observation?

BACKGROUND Several reports have suggested an association between prematurity and hepatoblastoma (HB). PROCEDURE Data were collected by questionnaires from 105 children with HB enrolled in a Children's Cancer Group (CCG) study. RESULTS Observed over expected rates were increased about 2- and 15+-fold for prematurity (<37 weeks at birth) and low birth weight (<1,000 g) respectively. Similar data were derived from a later CCG study of 36 HB children. CONCLUSIONS Early reports of a possible association between prematurity and HB have been confirmed.
Are central hospitals ready for National Health Insurance? ICD coding quality from an electronic patient discharge record for clinicians.

BACKGROUND South Africa (SA)'s planned National Health Insurance reforms require the use of International Statistical Classification of Diseases (ICD) codes for hospitals to purchase services from the proposed National Health Authority. However, compliance with coding at public hospitals in the Western Cape Province has been challenging. A computer application was developed to aid clinicians in integrating ICD coding into the patient hospital discharge process. OBJECTIVE To evaluate the quality of ICD codes captured using the application and predictors thereof in a single hospital department. METHODS After 6 months, the quality of ICD codes was determined by comparing ICD code descriptors with medical concepts in a random sample of original patient records selected over a 6-week period. Patient and personnel characteristics influencing quality of coding, derived from a theoretical framework, were collected. RESULTS Of 223 patient records, 45.3% (95% confidence interval (CI) 38.8 - 51.9) had complete ICD codes. Primary ICD code accuracy was 74.0% (95% CI 67.8 - 79.5). Patient characteristics such as female gender, younger age group and fewer comorbidities, as well as seniority of clinician rank, were significantly associated with ICD coding being complete on adjusted analysis. CONCLUSION The results of this study describe ICD coding quality at a central hospital in SA supported by a computer application and the factors influencing this. More interventions are required to achieve reliable coding data, such as additional ICD coding validation tools, training and oversight of junior clinicians.
Diffuse Attenuation Coefficients for East Antarctic Pack Ice and Snow at Ultraviolet and Visible Wavelengths

Declining stratospheric ozone concentrations have led to higher levels of ultraviolet (UV) B (UVB) radiation at the Earth's surface, particularly in Antarctic spring time. Increased exposure to UVB radiation can decrease the productivity of sea-ice algae, as well as cause damage to organisms living in the clear water beneath the Antarctic pack ice. Conversely, sea-ice algae and other photosynthetic organisms rely on photosynthetically active radiation (PAR) to drive and sustain growth. Field work performed during the 2007 Australian Antarctic Program Sea Ice Physics and Ecosystem eXperiment voyage to the East Antarctic sea-ice zone allowed the estimation of diffuse attenuation coefficients for pack ice and the overlying snow at UV wavelengths (305, 313, 320, 340, 380, and 395 nm) and for PAR. The UV attenuation coefficients were 9.6-12.7 m-1 for snow and 1.57-2.05 m-1 for pack ice. The PAR attenuation coefficients were 10.5 m-1 (snow) and 1.52 m-1 (pack ice). The attenuation coefficients for erythemally weighted UVB radiation were 11.3 m-1 (snow) and 1.82 m-1 (pack ice). The analysis also estimated the reflection coefficient (albedo) of snow as 0.67 for UV wavelengths and 0.68 for PAR, but the snow cover was not always optically thick.
Synthesis and immunogenicity of the rotavirus major capsid antigen using a baculovirus expression system

Rotaviruses are the major pathogens that cause life-threatening diarrhea in young children and animals. We inserted a simian rotavirus SA11 gene 6 cDNA into the genome of the baculovirus Autographa californica nuclear polyhedrosis virus adjacent to the strong polyhedrin promoter. The major capsid antigen (VP6) was expressed in high yields (20 to 150 micrograms/10(6) cells) when Spodoptera frugiperda cells were infected with baculovirus recombinants containing SA11 gene 6 inserts. Reactivity with monospecific polyclonal and monoclonal antibodies suggested that VP6, expressed intracellularly or found in the media, maintained native antigenic determinants. VP6 purified from the media from infected cells also possessed a native oligomeric structure, was immunogenic in guinea pigs, and was able to spontaneously assemble into morphologic subunits. Antisera from immunized guinea pigs failed to neutralize virus in plaque reduction assays, but detected homologous and heterologous rotavirus strains when tested by immunofluorescence, immunoprecipitation, and enzyme-linked immunosorbent assays.