Miracle-dz/UniFAR-FTUs huggingface dataset:
Sexual Dysfunctions in Men and Women with Inflammatory Bowel Disease: The Influence of IBD-Related Clinical Factors and Depression on Sexual Function.

INTRODUCTION Inflammatory bowel disease (IBD) is likely to have an impact on sexual function because of its symptoms, like diarrhea, fatigue, and abdominal pain. Depression is commonly reported in IBD and is also related to impaired sexual function. This study aimed to evaluate sexual function and its association with depression among patients with IBD compared with controls. METHODS IBD patients registered at two hospitals participated. The control group consisted of a general practitioner practice population. The web-based questionnaire included the Female Sexual Function Index (FSFI) for women and the International Index of Erectile Function (IIEF) for men. Other variables evaluated were depression, disease activity, IBD-related quality of life, body image, and fatigue. RESULTS In total, 168 female and 119 male patients were available for analysis (response rate 24%). Overall, patients with IBD did not significantly differ in prevalence of sexual dysfunctions from controls: female patients 52%, female controls 44%, male patients and male controls both 25%. However, men and women with an active disease scored significantly lower than patients in remission and controls, indicating impaired sexual functioning during disease activity. Significant associations were found between active disease, fatigue, depressive mood, quality of life, and sexual function for both male and female patients. The association between disease activity and sexual function was totally mediated by depression. CONCLUSION Male and female IBD patients with an active disease show impaired sexual function relative to patients in remission and controls. Depression is the most important determinant for impaired sexual function in IBD.
Evaluation of guideline for treatment of febrile neutropenia in pediatric cancer at Siriraj Hospital.

BACKGROUND Febrile neutropenia (FN) is a common and important clinical problem in pediatric cancer. Our Institution has developed a clinical practice guideline (CPG) for treatment of FN to assist the clinicians taking care of these patients. OBJECTIVE To evaluate characteristics of FN, sources and causative agents of infection, applicability and effectiveness of the CPG, and factors that associated with response to treatment. MATERIALS AND METHODS The medical records of patients with FN that had completed data from September, 2003 to May, 2005 were reviewed and analysed. RESULTS A total of 148 FN episodes in 90 patients were analysed. The predominant underlying malignancy was acute leukemia. About 50% had absolute neutrophil count (ANC) less than 100 cells/mm3 at the beginning and at reassesment on day 3 of treatment. The causes of infection with microbiological confirmation was 25%. Urinary tract infection was the predominant source of infection and gram negative bacteria was the predominant causative agent. Sixty-two percents responded to initial treatment without changing of antibiotics. Of all episodes, 91.2% were able to complete treatment according to the CPG. The mortality rate was 1.4%. ANC of less than 100 cell/mm3 on day 3 of treatment was the significant risk factor for prolonged duration of fever and unresponsiveness to low risk regimen of antibiotics. ANC of less than 100 cell/mm3 on day 3, having hematologic malignancies, and recurrent fever were associated risks for the need for antifungal agent or referral to infectious diseases specialist or death. The pretreatment ANC more than 100 cells/mm3 was a significant predictor for the responsiveness to low risk regimen without recurrent fever. CONCLUSION Our CPG could practically be applied in FN patients and resulted in low mortality rate.
A multi-criteria content-based filtering system

In this paper we present a novel filtering system, based on a new model which reshapes the aims of content-based filtering. The filtering system has been developed within the EC project PENG, aimed at providing news professionals, such as journalists, with a system supporting both filtering and retrieval capabilities. In particular, we suggest that in tackling the problem of information overload, it is necessary for filtering systems to take into account multiple aspects of incoming documents in order to estimate their relevance to a user's profile, and in order to help users better understand documents, as distinct from solely attempting to either select relevant material from a stream, or block inappropriate material. Aiming to so this, a filtering model based on multiple criteria has been defined, based on the ideas gleamed in the project requirements stage. The filtering model is briefly described in this paper.
Cognitive Aids in Acute Care: Investigating How Cognitive Aids Affect and Support In-hospital Emergency Teams

Cognitive aids - artefacts that support a user in the completion of a task at the time - have raised great interest to support healthcare staff during medical emergencies. However, the mechanisms of how cognitive aids support or affect staff remain understudied. We describe the iterative development of a tablet-based cognitive aid application to support in-hospital resuscitation team leaders. We report a summative evaluation of two different versions of the application. Finally, we outline the limitations of current explanations of how cognitive aids work and suggest an approach based on embodied cognition. We discuss how cognitive aids alter the task of the team leader (distributed cognition), the importance of the present team situation (socially situated), and the result of the interaction between mind and environment (sensorimotor coupling). Understanding and considering the implications of introducing cognitive aids may help to increase acceptance and effectiveness of cognitive aids and eventually improve patient safety.
Parallel developmental trajectories of sensation seeking and regular substance use in adolescents.

This study applied piecewise latent growth modeling to longitudinal survey data from 2 different samples of adolescents (N=1,002 and N=1,206) to examine the hypothesis that development of sensation seeking in middle school would predict development of substance use (cigarettes, alcohol, and marijuana) in middle school and high school. Results showed that sensation seeking had strong predictive value for both concurrent and distal marijuana and alcohol use in both samples; however, initial level of sensation seeking predicted initial level of cigarette use during high school in 1 sample only. White participants scored consistently higher on both initial level and rate of increase in sensation seeking than did participants of other ethnicities. Advantages of this methodology are discussed in the context of substance use research.
PCN-Based Flow Termination with Multiple Bottleneck Links

Pre-congestion notification (PCN) is a new packet marking scheme based on which simple measurement-based admission control (AC) and flow termination (FT) are implemented. FT is useful for traffic management in unexpected events, e.g., when admitted flows lead to overload on a link after rerouting which may be due to a link or node failure. While AC is a classic flow control function, FT is new and only little understood so far. The limited literature on FT focuses mainly on a single overloaded link. However, when a link or node fails, redirected traffic is likely to cause overload on multiple backup links (bottlenecks) at the same time. As the packet marking probability for flows traversing multiple bottlenecks is larger than for flows traversing only the most severe bottleneck, more traffic is possibly terminated than needed, i.e. overtermination occurs. This paper quantifies potential overtermination in case of multiple bottlenecks for different FT mechanisms which are currently discussed by the IETF.
Toward a New Geometric Distance to the Active Galaxy NGC 4258. I. VLBI Monitoring of Water Maser Emission

We report a 3 yr, 18 epoch, VLBI monitoring study of H2O masers in the subparsec, warped, accretion disk within the NGC 4258 AGN. Our immediate goals are to trace the geometry of the underlying disk, track rotation via measurement of proper motion, and ascertain the radii of masers for which centripetal acceleration may be measured separately. The monitoring includes ~4 times as many epochs, ~3 times denser sampling, and tighter control over sources of systematic error than earlier VLBI investigations. Coverage of a ~2400 km s-1 bandwidth has also enabled mapping of molecular material ~30% closer to the black hole than accomplished previously, which will strengthen geometric and dynamical disk models. Through repeated observation we have also measured for the first time a 5 μas (1 σ) thickness of the maser medium. Assuming that this corresponds to the thickness of the accretion disk, hydrostatic equilibrium requires a disk plane temperature of ≈600 K. Our long-term goal is a geometric distance to NGC 4258 that is accurate to ~3%, a ~2 times improvement over the current best estimate. A geometric estimate of distance can be compared to distances obtained from analysis of Cepheid light curves, with the intent to recalibrate the extragalactic distance scale with reduced systematic uncertainties. This is the first paper in a series. We present here VLBI observations, data reduction, and temporal and spatial characteristics of the maser emission. Later papers will report estimation of orbital acceleration and proper motion, modeling of disk 3D geometry and dynamics, and estimation of a "maser distance. " Estimation of a "Cepheid distance" is presented in a parallel paper series.
The evolution of SMBH spin and AGN luminosities for z < 6 within a semi-analytic model of galaxy formation

Understanding how Active Galactic Nuclei (AGN) evolve through cosmic time allows us to probe the physical processes that control their evolution. We use an updated model for the evolution of masses and spins of supermassive black holes (SMBHs), coupled to the latest version of the semi-analytical model of galaxy formation GALFORM using the Planck cosmology and a high resolution Millennium style dark matter simulation to make predictions for AGN and SMBH properties for $0 < z < 6$. We compare the model to the observed black hole mass function and the SMBH versus galaxy bulge mass relation at $z=0$, and compare the predicted bolometric, hard X-ray, soft X-ray and optical AGN luminosity functions to observations at $z < 6$, and find that the model is in good agreement with the observations. The model predicts that at $z<2$ and $L_{\mathrm{bol}} < 10^{43} \mathrm{ergs^{-1}}$, the AGN luminosity function is dominated by objects accreting in an Advection Dominated Accretion Flow (ADAF) disc state, while at higher redshifts and higher luminosities the dominant contribution is from objects accreting via a thin disc or at super-Eddington rates. The model also predicts that the AGN luminosity function at $z<3$ and $L_{\mathrm{bol}} < 10^{44} \mathrm{ergs^{-1}}$ is dominated by the contribution from AGN fuelled by quiescent hot halo accretion, while at higher luminosities and higher redshifts, the AGN luminosity function is dominated by the contribution from AGN fuelled by starbursts triggered by disc instabilities. We employ this model to predict the evolution of SMBH masses, Eddington ratios, and spins, finding that the median SMBH spin evolves very little for $0<z<6$.
Relationship between occupational stress, emotional intelligence, and self-efficacy among faculty members in faculty of nursing Zagazig University, Egypt

Background/Aim: Different studies, in international context, have linked occupational stress to emotional intelligence or self-efficacy of faculty members. However, investigating the relationship between these three constructs in this context was limited. So, the researchers investigated the relationship between occupational stress, emotional intelligence and self-efficacy among faculty members. Method: The study was conducted at the Faculty of Nursing, Zagazig University using a descriptive correlational design. A convenience sample of 91 faculty members working in Faculty of Nursing Zagazig University during the academic year 2011-2012 were recruited for the study. Four tools were used for data collection: Questionnaire about demographic data, Emotional Intelligence Scale, General Self-Efficacy Scale, and Occupational Stress Scale. Results: The study findings indicate that the majority of faculty members experience a high level of occupational stress, while they have a low level of emotional intelligence and self-efficacy. The occupational stress was negatively related with faculty members’ emotional intelligence and self-efficacy. Conclusion and Recommendation: The findings of current study confirm that occupational stress has negative relationships with the faculty members’ emotional intelligence and self-efficacy. Therefore, we suggest that the Faculty of Nursing should keep the stress level of their faculty members lower and help them to stay healthier by holding training courses on emotional intelligence improving their social skills and increase their efficiency at work. Moreover, the perceived self-efficacy can be improved among the faculty members through training programmes and courses this would help the faculty members enhance their stress bearing capacity and also improve their productivity.
Classical hardness of learning with errors

We show that the Learning with Errors (LWE) problem is classically at least as hard as standard worst-case lattice problems. Previously this was only known under quantum reductions. Our techniques capture the tradeoff between the dimension and the modulus of LWE instances, leading to a much better understanding of the landscape of the problem. The proof is inspired by techniques from several recent cryptographic constructions, most notably fully homomorphic encryption schemes.
Protein trans-Splicing To Produce Herbicide-Resistant Acetolactate Synthase

ABSTRACT Protein splicing in trans has been demonstrated both in vivo and in vitro by biochemical and immunological analyses, but in vivo production of a functional protein by trans-splicing has not been reported previously. In this study, we used the DnaE intein from Synechocystis sp. strain PCC6803, which presumably reconstitutes functional DnaE protein bytrans-splicing in vivo, to produce functional herbicide-resistant acetolactate synthase II (ALSII) from two unlinked gene fragments in Escherichia coli. The gene for herbicide-resistant ALSII was fused in frame to DnaE intein segments capable of promoting protein splicing in trans and was expressed from two compatible plasmids as two unlinked fragments. Cotransformation of E. coli with the two plasmids led to production of a functional enzyme that conferred herbicide resistance to the host E. coli cells. These results demonstrate the feasibility of expressing functional genes from two unlinked DNA loci and provide a model for the design of nontransferable transgenes in plants.
TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression

The Transducin-like enhancer of split 1 (TLE1) corepressor protein is overexpressed in human lung tumors and is a putative lung-specific oncogene. However, the molecular mechanism underlying its oncogenic function remains to be delineated. Here, we report an important role of TLE1 in promoting lung tumorigenesis by a mechanism involving induction of anoikis resistance. Using the human lung adenocarcinoma A549 and immortalized bronchial epithelial BEAS-2B cell lines, we observed that TLE1 inhibits anoikis through transcriptional repression of E-cadherin gene. In support of E-cadherin as a downstream target of TLE1 to block anoikis, forced expression of E-cadherin attenuated TLE1-induced anoikis resistance while E-cadherin downregulation decreased the anoikis sensitivity of TLE1 knockdown cells. Furthermore, we determined that E-cadherin expression is transcriptionally induced upon loss of cell attachment and functions as an effector of anoikis. Loss of E-cadherin via the siRNA strategy or exogenous TLE1 expression was sufficient to attenuate anoikis in A549 and BEAS-2B cells. Importantly, we demonstrated that the ZEB1 transcriptional factor is required for TLE1-mediated E-cadherin repression and anoikis resistance. ZEB1 interacted with and recruited the TLE1 to the E-cadherin promoter to impose histone deacetylation and gene silencing. In vivo, TLE1 strongly promoted tumorigenicity of A549 cells in a ZEB1-dependent manner. Underscoring its role in anoikis insensitivity of lung cancer cells, the TLE1-mediated E-cadherin repression was negatively regulated by the tumor suppressor Bcl-2 inhibitor of transcription 1 (Bit1) to effect anoikis. These findings identify the ZEB1/TLE1/E-cadherin transcriptional mechanism as a novel pathway that promotes anoikis resistance and oncogenicity of lung cancer cells.
Relaxing dynamic programming

The idea of dynamic programming is general and very simple, but the "curse of dimensionality" is often prohibitive and restricts the fields of application. This paper introduces a method to reduce the complexity by relaxing the demand for optimality. The distance from optimality is kept within prespecified bounds and the size of the bounds determines the computational complexity. Several computational examples are considered. The first is optimal switching between linear systems, with application to design of a dc/dc voltage converter. The second is optimal control of a linear system with piecewise linear cost with application to stock order control. Finally, the method is applied to a partially observable Markov decision problem (POMDP)
Early onset alcohol use and self-harm: a discordant twin analysis.

BACKGROUND Self-harm has considerable societal and economic costs and has been extensively studied in relation to alcohol involvement. Although early onset alcohol use (EAU) has been causally linked to maladaptive clinical outcomes, its association with self-harm is less well characterized. This study aimed to further examine the link between EAU and both nonsuicidal self-injury (NSSI) and suicide attempt (SA), and elucidate shared familial and causal/individual-specific pathways that explain this co-occurrence. METHODS Using data from 6,082 Australian same-sex twin pairs (1,732 monozygotic [MZ] and 1,309 dizygotic [DZ]), ages 23 to 40, we examined prevalence rates of NSSI and SA among twin pairs concordant and discordant for EAU. Conditional logistic regression, controlling for early clinical covariates and the influence of zygosity on EAU, was used to examine the odds ratio (OR) of self-harm within twin pairs discordant for EAU. RESULTS Prevalence rates of both NSSI and SA were highest among twin pairs concordant for EAU and for twins who reported EAU within discordant twin pairs. Results from discordant twin analyses revealed nearly 4-fold increased odds of SA for the twin who endorsed EAU, and this OR was equal across MZ and DZ twins. EAU also was associated with elevated odds of NSSI (OR = 7.62), although this was only the case for DZ twins in discordant pairs. CONCLUSIONS The equivalent increase in odds of SA for both MZ and DZ twins suggests that causal or individual-specific influences explain the link between EAU and SA. For NSSI, elevated odds for DZ twins and nonsignificant findings for MZ twins implicate correlated genetic factors in the association between EAU and NSSI. Future studies should test mechanisms through which EAU may causally influence SA, as well as examine whether genetic risk for third variables (e.g., negative urgency, stress reactivity) may explain the genetic overlap between EAU and NSSI.
Voice User Interfaces in Schools: Co-designing for Inclusion with Visually-Impaired and Sighted Pupils

Voice user interfaces (VUIs) are increasingly popular, particularly in homes. However, little research has investigated their potential in other settings, such as schools. We investigated how VUIs could support inclusive education, particularly for pupils with visual impairments (VIs). We organised focused discussions with educators at a school, with support staff from local authorities and, through bodystorming, with a class of 27 pupils. We then ran a series of co-design workshops with participants with mixed-visual abilities to design an educational VUI application. This provided insights into challenges faced by pupils with VIs in mainstream schools, and opened a space for educators, sighted and visually impaired pupils to reflect on and design for their shared learning experiences through VUIs. We present scenarios, a design space and an example application that show novel ways of using VUIs for inclusive education. We also reflect on co-designing with mixed-visual-ability groups in this space.
Lung Inflammation, Oxidative Stress and Air Pollution

This is a very relevant chapter in the context of “Lung Inflammation” because it details and discusses an important theme in this area: air pollution. The analyses of epidemiological studies, conducted in various urban centres, have provided coherent evidence that elevated levels of air pollution are associated with an increased risk of respiratory disease and mortality. The whole population is affected, but the active and athletic population is of special concern because of the amount of time they spend training and/or competing outdoors, eliciting high ventilation rates that result in higher pollutants delivery to the lungs. This chapter addresses the systemic effects that inhaled pollutants have as well as the local pulmonary inflammatory processes and oxidative stress. The consequences that these processes may impose to the health and performance of the active population will also be described. The use of antioxidants to counteract the deleterious oxidative stress of exercise when performed in a polluted environment is discussed here too.