Miracle-dz/UniFAR-FTUs huggingface dataset:
Are Personality Traits and Relationship Characteristics Reciprocally Related? Longitudinal Analyses of Codevelopment in the Transition out of High School and Beyond

Personality development has been associated with changes in various aspects of social relationships (e.g., contact frequency, emotional closeness, etc.). However, specific patterns of personality-relationship transactions are still not well understood as not many empirical studies have explored major life transitions. Emerging adulthood with its numerous life transitions is crucial for personality and social relationship development. In this study, we looked at personality–relationship transactions in the transition from high school to college, apprenticeship training, and so forth. We used Waves 1 to 3 of the Transformation of the Secondary School System and Academic Careers (TOSCA) study, which measured the Big Five (McCrae & Costa, 2008) and their facets as well as five relationship characteristics in social networks with one’s romantic partner, friends, kin, and others. Our analyses of extended bivariate latent difference score models revealed four main findings: First, there was an imbalance in personality–relationship transaction effects with the majority of effects occurring from personality to change in social relationships rather than in the opposite direction. Furthermore, only a few change-to-change associations occurred. Second, two thirds of the cross-lagged effects derived from personality facets. Third, the majority of effects were found in the second measurement interval (i.e., not during the transition out of high school, but in the time period after this transition). Finally, neuroticism and its facets, as well as conflict frequency and perceived feelings of insecurity in the relationship emerged as the most consistent associations in this age group. Theoretical and empirical implications for personality–relationship transaction patterns are discussed.
The modulation of corticospinal excitability and inhibition following acute resistance exercise in males and females

Abstract Objective: The acute responses to resistance training (RT) between males and females are poorly understood, especially from a neural perspective. Therefore, we aimed to compare the corticospinal and intracortical responses during fatigue and recovery following RT. Methods: Twenty-two participants (12M, 10F) completed one-session of RT (3 × 12 repetition maximum) unilateral leg extensions with 60 s recovery. Single- and paired-pulse transcranial magnetic stimulation measured changes in the motor-evoked potential (MEP), corticospinal silent period (CSP), CSP/MEP ratio, and intracortical facilitation/inhibition (ICF, SICI). The maximal compound wave (MMAX) measured peripheral excitability of the rectus femoris (RF) and maximal voluntary isometric contraction (MVIC) neuromuscular function of the leg extensors. Measures were taken immediately post, 30 min, 1 and 6 h post-training. Results: A significantly greater increase in MEP/MMAX ratio (p = .005) was observed for females immediately post-training compared to males. While no sex differences in MEP/MMAX ratio was observed at 30 min and 1 h post-training, a greater MEP/MMAX ratio for males was observed at 30 min (p < .001), which remained elevated up until 1 h post-training for males when compared to baseline (p = .003). CSP trended to decrease for males compared to females immediately post-training (d = 1.93). MVIC was decreased post-training for males; 14.22% and females; 14.16% (P < .001), with MMAX reduced at 30 min for both groups (P < .001). No differences in the CSP/MEP ratio, SICI or ICF were observed (P > .05). Conclusion: The net output of corticospinal excitability is similar between males and females during fatigue. However, the mechanism in which this is modulated (increased MEP, decreased CSP) appears to be sex-specific.
Evaluation of the utility of chemotaxonomic pigments as a surrogate for particulate DMSP

High‐performance liquid chromatography (HPLC) analysis of accessory pigments, which provides a detailed description of a phytoplankton assemblage over the whole size range, was combined with size fractionation of particulate di‐methylsulfoniopropionate (DMSPp) to assess the origin of DMSPp in the sea. More than 200 surface‐water samples were collected over contrasting regions of the ocean. Concentrations of DMSPp ranged between 6 and 190 nM. The size fraction <10 mm accounted for 65 ± 16% (1 sigma) of DMSPp on average. Concentrations of DMSPp in this size fraction were strongly linearly correlated (r2 = 0.84, n = 189, P < 0.0001) with the sum of concentrations of Hex‐fuco (prymnesiophytes) and But‐fuco (chrysophytes‐pelagophytes), after excluding 17 samples from the Ligurian Sea (Northwestern Mediterranean Sea) taken during the spring and summer seasons of 1993 and 1994. These samples were unusual because of their high DMSP content. Concentrations of Hex‐fuco + But‐fuco appear much better surrogates for DMSPp than for DMS. In the size fraction >10 mm, DMSPp was better correlated with peridinin (dinoflagellates) than fucoxanthin (diatoms) concentrations, but peridinin explained at most 25% of the variability in microplanktonic DMSP. Nearly peridinin‐free (<0.01 mg m−3) surface waters of the Ligurian Sea during spring and summer contained >15 nM of DMSPp in the size fraction >10 mm, i.e., 44 ± 15% of total DMSPp. Thus, the particulate material exhibited considerably more DMSP than expected from the levels of accessory pigments in the Ligurian Sea during the spring and summer seasons of 1993 and 1994. We suggest that this excess of DMSPp was contributed by heterotrophic nano‐ and microorganisms.
TEACHING WRITING RECOUNT TEXT THROUGH PERSONAL JOURNAL WRITING

Abstract : This research was conducted to find out whether Personal Journal Writing is effective and how effective it is in teaching writing recount text. This research was conducted to the tenth grade students of SMAN 3 Pontianak in Academic Year 2014/2015. In this research, a quasi experimental design was used by the writer. The samples were class XD as the experimental group and the control group was class XE. In this research, the result of t-test computation was 4.57 with degree of freedom is 65 and t-table is 2.00. It showed that the alternative hypothesis (Ha) that teaching writing recount text through personal journal writing is effective is accepted and the effectiveness was strong. In conclusion, personal journal writing can be a good alternative in teaching writing recount text on the tenth grade students of SMAN 3 Pontianak and in other schools which have similar characteristics to SMA Negeri 3 Pontianak. Keywords: Writing, Recount Text, Personal Journal Writing Abstrak: Penelitian ini dilakukan untuk mengetahui apakah Penulisan Jurnal Pribadi efektif dan seberapa efektif Penulisan Jurnal Pribadi dalam mengajar penulisan teks recount. Penelitian ini dilakukan pada siswa kelas 10 SMA Negeri 3 Pontianak tahun ajaran 2014/2015. Metode yang digunakan dalam penelitian ini adalah penelitian quasi-eksperimen. Sampel dari penelitian ini adalah kelas XD sebagai kelompok eksperimen dan kelas XE sebagai grup kontrol. Pada penelitian ini, hasil dari penghitungan uji-t adalah 4,57 dengan derajat kebebasan 65 dan t-table adalah 2,00. Hal ini menunjukkan bahwa hipotesa alternatif yang menyatakan bahwa mengajar penulisan teks recount adalah efektif diterima dan tingkat keefektifitasannya kuat. Kesimpulannya, penulisan jurnal pribadi bisa menjadi alternatif yang baik dalam mengajar menulis teks recount pada kelas 10 SMA Negeri 3 Pontianak dan di sekolah lain yang memunyai persamaan karakteristik dengan SMA Negeri 3 Pontianak. Kata Kunci: Menulis, Teks Recount, Penulisan Jurnal Pribadi
MicroRNA-150 inhibits the proliferation and metastasis potential of colorectal cancer cells by targeting iASPP

In the present study, the function of miR-150 and its downstream target iASPP in the growth and metastasis of colorectal cancer (CRC) cells was investigated. The expression of miR-150 and iASPP was first investigated in clinical CRC samples. Subsequently, the effects of miR-150 overexpression and iASPP inhibition on cell viability, cell cycle distribution, apoptosis, migration and invasion were detected with CCK-8, flow cytometry, scratch and Transwell assays. The interaction between miR-150 and iASPP was confirmed using a dual-luciferase assay. Subsequently, the key role of iASPP in the anti-CRC function of miR-150 was assessed by inducing the expression of the gene in miR-150 overexpressed SW480 cells. In clinical samples, the level of miR-150 was downregulated, while iASPP was induced. Enforced expression of miR-150 decreased the viability, induced G1 cell cycle arrest and apoptosis, and inhibited the migration and invasion of SW480 cells. Knockdown of iASPP exerted a similar effect on SW480 cells to that of the overexpression of miR-150. Dual-luciferase assay demonstrated that miR-150 directly bound to iASPP and inhibited its transcription. The function of miR-150 depended on the inhibition of iASPP; induced expression of iASPP in miR-150-knockdown SW480 and HCT116 cells restored cell viability, migration and invasion while inhibiting G1 cell cycle arrest and apoptosis. Increased expression of miR-150 suppressed viability, proliferation, migration and invasion of SW480 cells. Furthermore, iASPP was a direct target of miR-150 and played a key role in its anti-CRC function. miR-150 may be a promising predictor of prognosis in CRC patients.
Promoting and Harmful Effects of Steroid Hormones on Renal Stem/Progenitor Cell Development

In regenerative medicine much attention is given to stem/progenitor cells for a future therapy of acute and chronic renal failure. However, up to date sound cell biological knowledge about nephron renewal within the diseased kidney is lacking. Of special interest are steroid hormones occurring in the interstitial fluid. It is unknown, if they have promoting or hampering effects on the development of stem/progenitor cells. To investigate the influence of steroid hormones on regenerating tubules a realistic culture system is of great importance. An advanced technique creates an artificial interstitium promoting renal stem/progenitor cells to develop tubules between layers of polyester fleece. During perfusion culture with chemically defined Iscove's Modified Dulbecco's Medium (IMDM) individual steroid hormones can be administered. After a culture period of 13 days the effect on tubule development is analyzed by histochemical methods. Present experiments reveal that substances such as cholesterol and 17-α-hydroxyprogesterone do not exhibit a visible effect on renal stem/progenitor cells. However, atypical aggregation of few SBA-labeled cells in form of islets is found after treatment with progesterone, pregnenolone, 11-deoxycorticosterone and dihydrotestosterone. Numerous SBA-labeled cells within extended clusters are observed after application of testosterone, 17-β-estradiol, corticosterone and dexamethasone. In contrast, application of aldosterone exclusively leads to the formation of numerous intact tubules. In consequence, it is shown that distinct steroid hormones induce a shift in development from intact tubules to atypical cell islets and clusters. Such harmful effects have to be considered, when stem/progenitor cells are exposed after implantation to the interstitial fluid within diseased renal parenchyma.
Daily variation of gene expression in diverse rat tissues

Circadian information is maintained in mammalian tissues by a cell-autonomous network of transcriptional feedback loops that have evolved to optimally regulate tissue-specific functions. An analysis of daily gene expression in different tissues, as well as an evaluation of inter-tissue circadian variability, is crucial for a systems-level understanding of this transcriptional circuitry. Affymetrix gene chip measurements of liver, muscle, adipose, and lung tissues were obtained from a rich time series light/dark experiment, involving 54 normal rats sacrificed at 18 time points within the 24-hr cycle. Our analysis revealed a high degree of circadian regulation with a variable distribution of phases among the four tissues. Interestingly, only a small number of common genes maintain circadian activity in all tissues, with many of them consisting of “core-clock” components with synchronous rhythms. Our results suggest that inter-tissue circadian variability is a critical component of homeostatic body function and is mediated by diverse signaling pathways that ultimately lead to highly tissue-specific transcription regulation.
DNA Markers for Selection of Late Blight Resistant Potato Breeding Lines

Potato late blight, caused by the oomycete Phytophthora infestans, is one of the most devastating diseases in the agricultural sector around the world. Many genes (R genes) conferring resistance to late blight have been identified in various potato species and most of these R genes have been used in potato breeding. The aim of this study was to develop and validate PCR-based assays for the R genes Rpi-blb1, Rpi-blb2, Rpi-blb3 and Rpi-bt1, to distinguish between late blight resistant and late blight susceptible potato progeny in the given breeding background. A total of 100 breeding progeny were screened for the presence of these R genes and tested for resistance against P. infestans mating type A2, genotype US-8 strain, using detached leaf and tuber rot assays. PCR products for the Rpi-blb1 and Rpi-bt1 resistance genes were identified in the resistant progeny but were absent in the susceptible ones; therefore these PCR assays could differentiate between late blight resistant and susceptible plants. Genotypic data from the DNA markers derived from the Rpi-blb1 and Rpi-bt1 genes was found to correlate with the phenotypic data for foliar late blight but not with data for tuber rot. Our results demonstrate that markers derived from these two R genes could be useful for marker-assisted selection (MAS) for foliar late blight resistance in potato breeding programs.
Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients

ST-segment elevation myocardial infarction (STEMI) is the most severe outcome of coronary artery disease. Despite rapid reperfusion of the artery, acute irrigation of the cardiac tissue is associated with increased inflammation. While innate immune response in STEMI is well described, an in-depth characterization of adaptive immune cell dynamics and their potential role remains elusive. We performed a translational study using a controlled porcine reperfusion model of STEMI and the analysis of lymphocyte subsets in 116 STEMI patients undergoing percutaneous coronary intervention (PCI). In the animal model, a sharp drop in circulating T lymphocytes occurred within the first hours after reperfusion. Notably, increased apoptosis of circulating lymphocytes and infiltration of proinflammatory Th1 lymphocytes in the heart were observed 48 h after reperfusion. Similarly, in STEMI patients, a sharp drop in circulating T lymphocyte subsets occurred within the first 24 h post-PCI. A cardiac magnetic resonance (CMR) evaluation of these patients revealed an inverse association between 24 h circulating T lymphocyte numbers and infarction size at 1-week and 6-month post-PCI. Our translational approach revealed striking changes in the circulating and tissue-infiltrating T lymphocyte repertoire in response to ischemia-reperfusion. These findings may help in developing new diagnostic and therapeutic approaches for coronary diseases.
Coralline Hydroxyapatite Orbital Implant (Bio-Eye): Experience with 158 Patients

Purpose To assess the problems seen in 158 patients with coralline hydroxyapatite (HA) orbital implants (Bio-Eye). Methods A consecutive case series of 170 patients receiving coralline HA implanted by two surgeons over a 5-year period were reviewed. The authors analyzed age, type of surgery, implant size, peg system, follow-up duration, time of pegging, problems encountered, and treatment. Results Twelve patients were lost to follow-up after 5 months, leaving 158 patients who were followed from 6 to 130 months (average, 39 months). Problems in unpegged implants occurred in 36 (22.8%) patients. Discharge occurred in 18 (11.4%) patients, implant exposure in 12 (7.6%), socket discomfort in 1 (0.6%), conjunctival thinning in 3 (1.9%), chronic conjunctival swelling in 2 (1.3%), and implant infection in 3 (1.9%). Problems after pegging occurred in 68 (50.7%) of 134 patients: discharge in 27 (20.1%), pyogenic granuloma in 24 (17.9%), conjunctiva overgrowing the peg in 4 (3.0%), implant exposure around the sleeve in 5 (3.7%), clicking in 6 (4.5%), peg on an angle in 2 (1.5%), loose sleeve in 1 (0.7%), peg falling out in 18 (13.4%), popping peg in 1 (0.7%), poor transfer of movement in 3 (2.2%), pain with movement in 1 (0.7%), and implant infection in 2 (1.5%). Conclusions The Bio-Eye orbital implant represents a porous orbital implant that is biocompatible with orbital tissues and allows fibrovascular ingrowth and improved motility when coupled to the overlying artificial eye. It is more expensive than other commercially available porous orbital implants, such as synthetic FCI3 HA, porous polyethylene (Medpor), and aluminum oxide (Bioceramic) implant. Problems encountered with its use are similar to those problems seen in patients with the synthetic FCI3 hydroxyapatite and aluminum oxide orbital implants.
Spreading of Levantine Intermediate Waters by submesoscale coherent vortices in the northwestern Mediterranean Sea as observed with gliders

Since 2007, gliders have been regularly deployed in the northwestern Mediterranean Sea, a crucial region regarding the thermohaline circulation of the Mediterranean Sea. It revealed for the first time very warm (10.48C) and saline (10.1) submesoscale anticyclones at intermediate depth characterized by a small radius ($5 km), high Rossby ($0.3), and Burger ($0.7) numbers. They are likely order of 10 to be formed each year, have a life time order a year and certainly contribute significantly to the spreading of the Levantine Intermediate Waters (LIW) toward the whole subbasin, thus potentially impacting wintertime vertical mixing through hydrographical and dynamical preconditioning. They could be mainly formed by the combined action of turbulent mixing and flow detachment of the northward flow of LIW at the northwestern headland of Sardinia. Upwelling conditions along the western coast of Sardinia associated with a southward geostrophic flow within the upper layers seem to play a key role in their formation process.
Asymptotic expansion of stationary distribution for reflected Brownian motion in the quarter plane via analytic approach

Brownian motion in (mathbf{R}_+^2) with covariance matrix (Sigma) and drift (mu) in the interior and reflection matrix (R) from the axes is considered. The asymptotic expansion of the stationary distribution density along all paths in (mathbf{R}_+^2) is found and its main term is identified depending on parameters ((Sigma, mu, R)). For this purpose the analytic approach of Fayolle, Iasnogorodski and Malyshev in in [12] and [36], restricted essentially up to now to discrete random walks in (mathbf{Z}_+^2) with jumps to the nearest-neighbors in the interior is developed in this article for diffusion processes on (mathbf{R}_+^2) with reflections on the axes. <script type="text/javascript" src="//cdn.mathjax. org/mathjax/latest/MathJax.js? config=TeX-AMS-MML_HTMLorMML">
Sub-Gaussian estimators of the mean of a random vector

We study the problem of estimating the mean of a random vector $X$ given a sample of $N$ independent, identically distributed points. We introduce a new estimator that achieves a purely sub-Gaussian performance under the only condition that the second moment of $X$ exists. The estimator is based on a novel concept of a multivariate median.
Association Between Progesterone Elevation on the Day of Human Chronic Gonadotropin Trigger and Pregnancy Outcomes After Fresh Embryo Transfer in In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles

Progesterone elevation (PE) during the late follicular phase of controlled ovarian stimulation in fresh embryo transfer in vitro fertilization (IVF)/intracytoplasmic sperm injection cycles has been claimed to be associated with decreased pregnancy rates. However, the evidence is not unequivocal, and clinicians still have questions about the clinical validity of measuring P levels during the follicular phase of stimulated cycles. We reviewed the existing literature aimed at answering four relevant clinical questions, namely (i) Is gonadotropin type associated with PE during the follicular phase of stimulated cycles? (ii) Is PE on the day of human chorionic gonadotropin (hCG) associated with negative fresh embryo transfer IVF/intracytoplasmic sperm injection (ICSI) cycles outcomes in all patient subgroups? (iii) Which P thresholds are best to identify patients at risk of implantation failure due to PE in a fresh embryo transfer? and (iv) Should a freeze all policy be adopted in all the cycles with PE on the day of hCG? The existing evidence indicates that late follicular phase progesterone rise in gonadotropin releasing analog cycles is mainly caused by the supraphysiological stimulation of granulosa cells with exogenous follicle-stimulating hormone. Yet, the type of gonadotropin used for stimulation seems to play no significant role on progesterone levels at the end of stimulation. Furthermore, PE is not a universal phenomenon with evidence indicating that its detrimental consequences on pregnancy outcomes do not affect all patient populations equally. Patients with high ovarian response to control ovarian stimulation are more prone to exhibit PE at the late follicular phase. However, in studies showing an overall detrimental effect of PE on pregnancy rates, the adverse effect of PE on endometrial receptivity seems to be offset, at least in part, by the availability of good quality embryo for transfer in women with a high ovarian response. Given the limitations of the currently available assays to measure progesterone at low ranges, caution should be applied to adopt specific cutoff values above which the effect of progesterone rise could be considered detrimental and to recommend “freeze-all” based solely on pre-defined cutoff points.
Measuring the Utility of Search Engine Result Pages: An Information Foraging Based Measure

Web Search Engine Result Pages (SERPs) are complex responses to queries, containing many heterogeneous result elements (web results, advertisements, and specialised "answers'') positioned in a variety of layouts. This poses numerous challenges when trying to measure the quality of a SERP because standard measures were designed for homogeneous ranked lists. In this paper, we aim to measure the utility and cost of SERPs. To ground this work we adopt the \CWL framework which enables a direct comparison between different measures in the same units of measurement, i.e. expected (total) utility and cost. Within this framework, we propose a new measure based on information foraging theory, which can account for the heterogeneity of elements, through different costs, and which naturally motivates the development of a user stopping model that adapts behaviour depending on the rate of gain. This directly connects models of how people search with how we measure search, providing a number of new dimensions in which to investigate and evaluate user behaviour and performance. We perform an analysis over~1000 popular queries issued to a major search engine, and report the aggregate utility experienced by users over time. Then in an comparison against common measures, we show that the proposed foraging based measure provides a more accurate reflection of the utility and of observed behaviours (stopping rank and time spent).