Miracle-dz/UniFAR-FTUs huggingface dataset:
Three-dimensional mandibular motion in skeletal Class III patients

Abstract Objective: The aim of the study was to analyze the characteristics and changes in mandibular condylar motion in patients with skeletal Class III malocclusion. Methods: Using a 3D motion analyzer, mandibular movements were recorded in 9 patients with skeletal Class III malocclusion and 22 control subjects with Angle Class I jaw relationships. Results: Class III patients had a similar interincisor point displacement but a significantly reduced displacement of both condyles on the sagittal and frontal planes, with smaller translation paths than control subjects (right −9.4 mm; left −4.8 mm). The overall condylar rotation component was larger in Class III patients (right +8.8%; left +7.3%). The largest inter-group significant differences were observed in the first 10% of mouth opening, in which Class III patients had a larger rotating component than control subjects (+20%, p < 0.01). Conclusions: Condylar motion was reduced in skeletal Class III patients, in particular in the translational path.
Two‐Year Follow‐Up Magnetic Resonance Imaging and Spectroscopy Findings and Cerebrospinal Fluid Analysis of a Dog with Sandhoff's Disease

A 13‐month‐old female Toy Poodle was presented for progressive ataxia and intention tremors of head movement. The diagnosis of Sandhoff's disease (GM2 gangliosidosis) was confirmed by deficient β‐N‐acetylhexosaminidase A and B activity in circulating leukocytes and identification of the homozygous mutation (HEXB: c.283delG). White matter in the cerebrum and cerebellum was hyperintense on T2‐weighted and fluid‐attenuated inversion recovery magnetic resonance images. Over the next 2 years, the white matter lesions expanded, and bilateral lesions appeared in the cerebellum and thalamus, associated with clinical deterioration. Magnetic resonance spectroscopy showed progressive decrease in brain N‐acetylaspartate, and glycine‐myo‐inositol and lactate‐alanine were increased in the terminal clinical stage. The concentrations of myelin basic protein and neuron specific enolase in cerebrospinal fluid were persistently increased. Imaging and spectroscopic appearance correlated with histopathological findings of severe myelin loss in cerebral and cerebellar white matter and destruction of the majority of cerebral and cerebellar neurons.
Matrix exopolysaccharides; the sticky side of biofilm formation

Abstract The Gram-negative pathogen Pseudomonas aeruginosa is found ubiquitously within the environment and is recognised as an opportunistic human pathogen that commonly infects burn wounds and immunocompromised individuals, or patients suffering from the autosomal recessive disorder cystic fibrosis (CF). During chronic infection, P. aeruginosa is thought to form structured aggregates known as biofilms characterised by a self-produced matrix which encases the bacteria, protecting them from antimicrobial attack and the host immune response. In many cases, antibiotics are ineffective at eradicating P. aeruginosa from chronically infected CF airways. Cyclic-di-GMP has been identified as a key regulator of biofilm formation; however, the way in which its effector proteins elicit a change in biofilm formation remains unclear. Identifying regulators of biofilm formation is a key theme of current research and understanding the factors that activate biofilm formation may help to expose potential new drug targets that slow the onset of chronic infection. This minireview outlines the contribution made by exopolysaccharides to biofilm formation, and describes the current understanding of biofilm regulation in P. aeruginosa with a particular focus on CF airway-associated infections.
Enumerating Active IPv6 Hosts for Large-Scale Security Scans via DNSSEC-Signed Reverse Zones

Security research has made extensive use of exhaustive Internet-wide scans over the recent years, as they can provide significant insights into the overall state of security of the Internet, and ZMap made scanning the entire IPv4 address space practical. However, the IPv4 address space is exhausted, and a switch to IPv6, the only accepted long-term solution, is inevitable. In turn, to better understand the security of devices connected to the Internet, including in particular Internet of Things devices, it is imperative to include IPv6 addresses in security evaluations and scans. Unfortunately, it is practically infeasible to iterate through the entire IPv6 address space, as it is 2^96 times larger than the IPv4 address space. Therefore, enumeration of active hosts prior to scanning is necessary. Without it, we will be unable to investigate the overall security of Internet-connected devices in the future. In this paper, we introduce a novel technique to enumerate an active part of the IPv6 address space by walking DNSSEC-signed IPv6 reverse zones. Subsequently, by scanning the enumerated addresses, we uncover significant security problems: the exposure of sensitive data, and incorrectly controlled access to hosts, such as access to routing infrastructure via administrative interfaces, all of which were accessible via IPv6. Furthermore, from our analysis of the differences between accessing dual-stack hosts via IPv6 and IPv4, we hypothesize that the root cause is that machines automatically and by default take on globally routable IPv6 addresses. This is a practice that the affected system administrators appear unaware of, as the respective services are almost always properly protected from unauthorized access via IPv4. Our findings indicate (i) that enumerating active IPv6 hosts is practical without a preferential network position contrary to common belief, (ii) that the security of active IPv6 hosts is currently still lagging behind the security state of IPv4 hosts, and (iii) that unintended IPv6 connectivity is a major security issue for unaware system administrators.
MPST: A Corpus of Movie Plot Synopses with Tags

Social tagging of movies reveals a wide range of heterogeneous information about movies, like the genre, plot structure, soundtracks, metadata, visual and emotional experiences. Such information can be valuable in building automatic systems to create tags for movies. Automatic tagging systems can help recommendation engines to improve the retrieval of similar movies as well as help viewers to know what to expect from a movie in advance. In this paper, we set out to the task of collecting a corpus of movie plot synopses and tags. We describe a methodology that enabled us to build a fine-grained set of around 70 tags exposing heterogeneous characteristics of movie plots and the multi-label associations of these tags with some 14K movie plot synopses. We investigate how these tags correlate with movies and the flow of emotions throughout different types of movies. Finally, we use this corpus to explore the feasibility of inferring tags from plot synopses. We expect the corpus will be useful in other tasks where analysis of narratives is relevant.
Mg–Ca–Zn bulk metallic glasses with high strength and significant ductility

The development of Mg–Ca–Zn metallic glasses with improved bulk glass forming ability, high strength, and significant ductility is reported. A typical size of at least 3–4 mm amorphous samples can be prepared using conventional casting techniques. By varying the composition, the mass density of these light metal based bulk amorphous alloys ranges from 2.0 to 3.0 g/cm^3. The typical measured microhardness is 2.16 GPa, corresponding to a fracture strength of about 700 MPa and specific strength of around 250–300 MPa cm^3/g. Unlike other Mg- or Ca-based metallic glasses, the present Mg–Ca–Zn amorphous alloys show significant ductility.
The Firm Size Distribution Across Countries and Skill-Biased Change in Entrepreneurial Technology

Development is associated with systematic changes in the firm size distribution. I document that the mean and dispersion of firm size are larger in rich countries, and increased over time for US firms. To analyze the firm size-development link, I construct a frictionless general equilibrium model of occupational choice with skill-biased change in entrepreneurial technology (i.e., technical progress favors better entrepreneurs). The model accounts for key aspects of the US experience with only changes in aggregate technology. It attributes half the variation in mean and dispersion of firm size across countries to technical change. Distortions also affect the size distribution. (JEL J24, L11, L25, L26, O33)
Predictors of Posthepatectomy Ascites with or without Previous Portal Vein Embolization

Aim: To identify predictors of postoperative ascites after liver resection for patients with or without preoperative portal vein embolization (PVE). Methods: Patients undergoing PVE prior to hepatectomy (PVE group; n = 37) were compared with patients who underwent liver resection without PVE (n = 503). Ascites was defined as postoperative daily drainage of clear ascitic fluid exceeding 200 ml/day. Pre-, intra-, and postoperative variables were retrospectively analyzed using uni- and multivariate analyses. Results: Postoperative ascites was present in 13.5% (5/37) of patients who underwent PVE before hepatectomy, compared to 5.8% (29/503) in the group undergoing liver resection without PVE (p = 0.061). In all patients, cirrhosis (OR 54.505, p < 0.001), operation time (OR 1.004, p = 0.014), and the use of the Pringle maneuver (OR 2.336, p = 0.041) were independent risk predictors for ascites in multivariate analysis. In PVE patients, cirrhosis (OR 0.156, p < 0.001) was the only independent significant predictor of ascites after resection. In patients undergoing liver resection without PVE, independent risk factors with multivariate analysis were operation time (OR 1.005, = 0.001) and cirrhosis (OR 26.609, p < 0.001). Conclusion: Operation time and the use of the Pringle maneuver were significant predictors of ascites after hepatectomy. Cirrhosis was a significant risk factor associated with postoperative ascites.
Stochastic Gradient Descent on Highly-Parallel Architectures

There is an increased interest in building data analytics frameworks with advanced algebraic capabilities both in industry and academia. Many of these frameworks, e.g., TensorFlow and BIDMach, implement their compute-intensive primitives in two flavors---as multi-thread routines for multi-core CPUs and as highly-parallel kernels executed on GPU. Stochastic gradient descent (SGD) is the most popular optimization method for model training implemented extensively on modern data analytics platforms. While the data-intensive properties of SGD are well-known, there is an intense debate on which of the many SGD variants is better in practice. In this paper, we perform a comprehensive study of parallel SGD for training generalized linear models. We consider the impact of three factors -- computing architecture (multi-core CPU or GPU), synchronous or asynchronous model updates, and data sparsity -- on three measures---hardware efficiency, statistical efficiency, and time to convergence. In the process, we design an optimized asynchronous SGD algorithm for GPU that leverages warp shuffling and cache coalescing for data and model access. We draw several interesting findings from our extensive experiments with logistic regression (LR) and support vector machines (SVM) on five real datasets. For synchronous SGD, GPU always outperforms parallel CPU---they both outperform a sequential CPU solution by more than 400X. For asynchronous SGD, parallel CPU is the safest choice while GPU with data replication is better in certain situations. The choice between synchronous GPU and asynchronous CPU depends on the task and the characteristics of the data. As a reference, our best implementation outperforms TensorFlow and BIDMach consistently. We hope that our insights provide a useful guide for applying parallel SGD to generalized linear models.
Acute Kidney Injury in Cardiorenal Syndrome Type 1 Patients: A Systematic Review and Meta-Analysis

Background: We evaluated the epidemiology and outcome of acute kidney injury (AKI) in patients with cardiorenal syndrome type 1 (CRS-1) and its subgroups: acute heart failure (AHF), acute coronary syndrome (ACS) and after cardiac surgery (CS). Summary: We performed a systematic review and meta-analysis. CRS-1 was defined by AKI (based on RIFLE, AKIN and KDIGO), worsening renal failure (WRF) and renal replacement therapy (RRT). We investigated the three most common clinical causes of CRS-1: AHF, ACS and CS. Out of 332 potential papers, 64 were eligible - with AKI used in 41 studies, WRF in 25 and RRT in 20. The occurrence rate of CRS-1, defined by AKI, WRF and RRT, was 25.4, 22.4 and 2.6%, respectively. AHF patients had a higher occurrence rate of CRS-1 compared to ACS and CS patients (AKI: 47.4 vs. 14.9 vs. 22.1%), but RRT was evenly distributed among the types of acute cardiac disease. AKI was associated with an increased mortality rate (risk ratio = 5.14, 95% CI 3.81-6.94; 24 studies and 35,227 patients), a longer length of stay in the intensive care unit [LOSICU] (median duration = 1.37 days, 95% CI 0.41-2.33; 9 studies and 10,758 patients) and a longer LOS in hospital [LOShosp] (median duration = 3.94 days, 95% CI 1.74-6.15; 8 studies and 35,227 patients). Increasing AKI severity was associated with worse outcomes. The impact of CRS-1 defined by AKI on mortality was greatest in CS patients. RRT had an even greater impact compared to AKI (mortality risk ratio = 9.2, median duration of LOSICU = 10.6 days and that of LOShosp = 20.2 days). Key Messages: Of all included patients, almost one quarter developed AKI and approximately 3% needed RRT. AHF patients experienced the highest occurrence rate of AKI, but the impact on mortality was greatest in CS patients.
Representative strain of indentation analysis

Indentation analysis based on the concept of representative strain offers an effective way of obtaining mechanical properties, especially work-hardening behavior of metals, from reverse analysis of indentation load–displacement data, and does not require measuring of the projected contact area. The definition of representative strain adopted in previous studies [e.g., Dao et al., Acta Mater. 49 , 3899 (2001)] has a weak physical basis, and it works only for a limited range in some sense of engineering materials. A new indentation stress-state based formulation of representation is proposed in this study, which is defined as the plastic strain during equi-biaxial loading. Extensive numerical analysis based on the finite element method has shown that with the new formulation of representative strain and representative stress, the critical normalized relationship between load and material parameters is essentially independent of the work-hardening exponent for all engineering materials, and the results also hold for three distinct indenter angles. The new technique is used for four materials with mechanical properties outside the applicable regime of previous studies, and the reverse analysis has validated the present analysis. The new formulation based on indentation stress-state based definition of representative strain has the potential to quickly and effectively measure the mechanical properties of essentially all engineering materials as long as their constitutive behavior can be approximated into a power-law form.
Activity recognition based on semantic spatial relation

We propose an approach to recognize group activities which involve several persons based on modeling the interactions between human bodies. Benefitted from the recent progress in pose estimation [1], we model the activities as the interactions between the parts belong to the same person (intra-person) and those between the parts of different persons (inter-person). Then a unified, discriminative model which integrates both types of interactions is developed. The experiments on the UT-Interaction Dataset [2] show the promising results and demonstrate the power of the interacting models.
Follicular lymphomas and their transformation: Past and current research

ABSTRACT Introduction: Follicular lymphoma (FL) is the second most common type of non-Hodgkin lymphoma (NHL). Histological transformation (HT) refers to the evolution of a clinically indolent NHL to a clinically aggressive one, defined as those lymphomas in which survival is limited to a few months when untreated. Areas covered: HT is associated with rapid progression of lymphadenopathy, infiltration of extranodal sites, development of systemic symptoms, and elevated serum level of lactate dehydrogenase (LDH). It is frequently related to a poor prognosis, and the median survival after transformation is less than 2 years. Transformation to diffuse large B cell lymphoma (DLBCL) in patients with FL occurs at an annual rate of approximately 3% for the first 15 years, after which the risk of HT falls for reasons that remain unclear. Expert commentary: Although it has long been assumed that transformation reflects the emergence of an aggressive subclone of cells from the primary FL, recent studies suggest that FL transformation might also arise by divergent evolution from a more immature common progenitor cell. Studies on genomic changes and DNA sequencing have shed some light onto the process of transformation. Nowadays, we know that HT is a complex process where several molecular pathways are involved.
Systematic Review Methodology for the Fatigue in Emergency Medical Services Project

Abstract Background: Guidance for managing fatigue in the Emergency Medical Services (EMS) setting is limited. The Fatigue in EMS Project sought to complete multiple systematic reviews guided by seven explicit research questions, assemble the best available evidence, and rate the quality of that evidence for purposes of producing an Evidence Based Guideline (EBG) for fatigue risk management in EMS operations. Methods: We completed seven systematic reviews that involved searches of six databases for literature relevant to seven research questions. These questions were developed a priori by an expert panel and framed in the Population, Intervention, Comparison, and Outcome (PICO) format and pre-registered with PROSPERO. Our target population was defined as persons 18 years of age and older classified as EMS personnel or similar shift worker groups. A panel of experts selected outcomes for each PICO question as prescribed by the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. We pooled findings, stratified by study design (experimental vs. observational) and presented results of each systematic review in narrative and quantitative form. We used meta-analyses of select outcomes to generate pooled effects. We used the GRADE methodology and the GRADEpro software to designate a quality of evidence rating for each outcome. Results: We present the results for each systematic review in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). More than 38,000 records were screened across seven systematic reviews. The median, minimum, and maximum inter-rater agreements (Kappa) between screeners for our seven systematic reviews were 0.66, 0.49, and 0.88, respectively. The median, minimum, and maximum number of records retained for the seven systematic reviews was 13, 1, and 100, respectively. We present key findings in GRADE Evidence Profile Tables in separate publications for each systematic review. Conclusions: We describe a protocol for conducting multiple, simultaneous systematic reviews connected to fatigue with the goal of creating an EBG for fatigue risk management in the EMS setting. Our approach may be informative to others challenged with the creation of EBGs that address multiple, inter-related systematic reviews with overlapping outcomes.
In Vitro Activity of Aztreonam-Avibactam against Enterobacteriaceae and Pseudomonas aeruginosa Isolated by Clinical Laboratories in 40 Countries from 2012 to 2015

ABSTRACT The combination of the monobactam aztreonam and the non-β-lactam β-lactamase inhibitor avibactam is currently in clinical development for the treatment of serious infections caused by metallo-β-lactamase (MBL)-producing Enterobacteriaceae, a difficult-to-treat subtype of carbapenem-resistant Enterobacteriaceae for which therapeutic options are currently very limited. The present study tested clinically significant isolates of Enterobacteriaceae (n = 51,352) and Pseudomonas aeruginosa (n = 11,842) collected from hospitalized patients in 208 medical center laboratories from 40 countries from 2012 to 2015 for in vitro susceptibility to aztreonam-avibactam, aztreonam, and comparator antimicrobial agents using a standard broth microdilution methodology. Avibactam was tested at a fixed concentration of 4 μg/ml in combination with 2-fold dilutions of aztreonam. The MIC90s of aztreonam-avibactam and aztreonam were 0.12 and 64 μg/ml, respectively, for all Enterobacteriaceae isolates; >99.9% of all isolates and 99.8% of meropenem-nonsusceptible isolates (n = 1,498) were inhibited by aztreonam-avibactam at a concentration of ≤8 μg/ml. PCR and DNA sequencing identified 267 Enterobacteriaceae isolates positive for MBL genes (NDM, VIM, IMP); all Enterobacteriaceae carrying MBLs demonstrated aztreonam-avibactam MICs of ≤8 μg/ml and a MIC90 of 1 μg/ml. Against all P. aeruginosa isolates tested, the MIC90 of both aztreonam-avibactam and aztreonam was 32 μg/ml; against MBL-positive P. aeruginosa isolates (n = 452), MIC90 values for aztreonam-avibactam and aztreonam were 32 and 64 μg/ml, respectively. The current study demonstrated that aztreonam-avibactam possesses potent in vitro activity against a recent, sizeable global collection of Enterobacteriaceae clinical isolates, including isolates that were meropenem nonsusceptible, and against MBL-positive isolates of Enterobacteriaceae, for which there are few treatment options.
The BEIR VII Estimates of Low-Dose Radiation Health Risks Are Based on Faulty Assumptions and Data Analyses: A Call for Reassessment

The 2006 National Academy of Sciences Biologic Effects of Ionizing Radiation (BEIR) VII report is a well-recognized and frequently cited source on the legitimacy of the linear no-threshold (LNT) model—a model entailing a linear and causal relationship between ionizing radiation and human cancer risk. Linearity means that all radiation causes cancer and explicitly excludes a threshold below which radiogenic cancer risk disappears. However, the BEIR VII committee has erred in the interpretation of its selected literature; specifically, the in vitro data quoted fail to support LNT. Moreover, in vitro data cannot be considered as definitive proof of cancer development in intact organisms. This review is presented to stimulate a critical reevaluation by a BEIR VIII committee to reassess the validity, and use, of LNT and its derived policies.