Miracle-dz/UniFAR-FTUs huggingface dataset:
Women younger than 65 years with diabetes mellitus are a high-risk group after myocardial infarction: a report from the Swedish Register of Information and Knowledge about Swedish Heart Intensive Care Admission (RIKS-HIA)

Objective: To analyse gender differences in prognosis, risk factors and evidence-based treatment in patients with diabetes and myocardial infarction. Methods: Mortality in 1995–2002 was analysed in 70 882 Swedish patients (age <80) with a first registry-recorded acute myocardial infarction stratified by gender and age. Owing to gender differences in mortality, specifically characterising patients below the age of 65 years, a more detailed analysis was performed within this cohort of 25 555 patients. In this group, 5786 (23%) were women and 4473 (18%) had diabetes. Differences in clinical and other parameters were adjusted for using a propensity score model. Results: Long-term mortality in diabetic patients aged <65 years was significantly higher in women than men (RR 1.34; 95% CI 1.16 to 1.55). Compared with diabetic men, women had an increased risk factor burden (hypertension 49 vs 43%; RR 1.12; 95% CI 1.05 to 1.20; heart failure 10 vs 8%; RR 1.25; 95% CI 1.03 to 1.53). Diabetic women aged <65 years were less frequently treated with intravenous β-blockade during the acute hospital phase and with angiotensin-converting enzyme inhibitors at hospital discharge. However, this under-use was not associated with the mortality differences, nor was female gender by itself. Conclusion: Women below 65 years of age with diabetes have a poorer outcome than men after a myocardial infarction. This relates to an increased risk factor burden. It is suggested that greater awareness of this situation and improved prevention have the potential to improve what is an unfavourable situation for these women.
Lessons from Medicare’s Demonstration Projects on Disease Management, Care Coordination, and Value-Based Payment

An important part of the national debate about how to manage federal spending in the decades ahead has focused on spending for Medicare, which is expected to account for a large and ever-increasing share of the federal budget. Medicare provides health insurance to almost everyone who is 65 or older and to people under age 65 who receive Social Security Disability Insurance benefits (after a waiting period) or have certain serious health conditions. Many observers point out that improving the effectiveness of Medicare spending might allow both for reductions in federal spending from its projected path and for improved health care for Medicare beneficiaries.
The evaluation of post-school psychological services pathfinders in Scotland (2004-2006)

In April 2004, Post-School Psychological Service (PSPS) Pathfinders were established for a 2-year period in 12 local authorities: Angus, Clackmannanshire, Dundee, Edinburgh, Falkirk, Fife, Glasgow, Midlothian, Perth & Kinross, South Lanarkshire, Stirling and West Lothian. These represented an extension of the existing work of educational psychology services with the 0-19 age group. Provision was also made for 2 Strategic Officers (SOs) to support local services and to work strategically at national level. PSPS works collaboratively with key stakeholders, and in particular with Scotland's Colleges, Careers Scotland, Scottish Enterprise and local training providers.
INCREASED URINARY URONIC ACID EXCRETION IN EXPERIMENTALLY-INDUCED RENAL PAPILLARY NECROSIS IN RATS

We have evaluated the potential of urinary uronic acid measurement as an early indicator in the development of renal papillary necrosis (RPN). Urinary uronic acid was quantified with a range of other urinary biochemical parameters in rats given multiple doses of N-phenylanthranilic acid (NPAA) or mefenamic acid (MFA), each of which induces a dose-related papillary necrosis. In addition, histological examination was also carried out to confirm the development and presence of RPN. NPAA was administered to male wistar rats at p.o. doses of 100, 250, and 500 mg/kg and MFA at p.o. doses of 75, 150, and 300 mg/kg on days 1–4 and 8–11, and urine samples were collected for 16 hours each day. NPAA increased uronic acid excretion two-fold for both medium and high doses from day four. MFA increased uronic acid excretion to two and a half-fold by day 10 in the highest dose administered. Urinary creatinine was equally elevated in a dose-related manner following treatment with either NPAA or MFA. None of the other routine markers (urinary or serum) of nephrotoxicity showed any statistical changes. NPAA produced a dose- and time-related increase in excretion of uronic acid. Evidence of widespread papillary necrosis was seen histologically at the high doses of NPAA or MFA. The significant elevation of uronic acid in urine following treatment with either NPAA or MFA was well ahead of the development of RPN detectable by routine histology, suggesting that uronic acid measurement could serve as an early indicator of RPN. The assessment of urinary uronic acid may therefore provide a novel sensitive and selective marker of identifying the lesion earlier than is currently possible. An increase in urinary uronic acid following NPAA and MFA treatment supports the biochemical basis of these changes as a representative of acid mucopolysaccharides accumulation.
Differential Modulation of TCF/LEF-1 Activity by the Soluble LRP6-ICD

The canonical Wnt/β-catenin (Wnt) pathway is a master transcriptional regulatory signaling pathway that controls numerous biological processes including proliferation and differentiation. As such, transcriptional activity of the Wnt pathway is tightly regulated and/or modulated by numerous proteins at the level of the membrane, cytosol and/or nucleus. In the nucleus, transcription of Wnt target genes by TCF/LEF-1 is repressed by the long Groucho/TLE co-repressor family. However, a truncated member of the Groucho/TLE family, amino terminal enhancer of Split (AES) can positively modulate TCF/LEF-1 activity by antagonizing long Groucho/TLE members in a dominant negative manner. We have previously shown the soluble intracellular domain of the LRP6 receptor, a receptor required for activation of the Wnt pathway, can positively regulate transcriptional activity within the Wnt pathway. In the current study, we show the soluble LRP6 intracellular domain (LRP6-ICD) can also translocate to the nucleus in CHO and HEK 293T cells and in contrast to cytosolic LRP6-ICD; nuclear LRP6-ICD represses TCF/LEF-1 activity. In agreement with previous reports, we show AES enhances TCF/LEF-1 mediated reporter transcription and further we demonstrate that AES activity is spatially regulated in HEK 293T cells. LRP6-ICD interacts with AES exclusively in the nucleus and represses AES mediated TCF/LEF-1 reporter transcription. These results suggest that LRP6-ICD can differentially modulate Wnt pathway transcriptional activity depending upon its subcellular localization and differential protein-protein interactions.
Questioning the continuum: specialization in rock climbing

Recreation specialization was originally conceived as a behavioral continuum ranging from general to more particular behaviors within an activity. It was assumed that an individual progressed from one subactivity to another in a hierarchical order. In recent years the practicality of such ordering has come under doubt; it may be possible to specialize in individual subactivities without progressing through a hierarchy. The objective of this research was to examine specialization in the activity of rock climbing by testing whether the arrangement of subactivities along a continuum was appropriate or whether an alternate conception of specialization should be employed.
Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR

Indomethacin, a cyclooxygenase‐1 and ‐2 inhibitor widely used in the clinic for its potent anti‐inflammatory/analgesic properties, possesses antiviral activity against several viral pathogens; however, the mechanism of antiviral action remains elusive. We have recently shown that indomethacin activates the double‐stranded RNA (dsRNA)‐dependent protein kinase R (PKR) in human colon cancer cells. Because of the important role of PKR in the cellular defence response against viral infection, herein we investigated the effect of indomethacin on PKR activity during infection with the prototype rhabdovirus vesicular stomatitis virus. Indomethacin was found to activate PKR in an interferon‐ and dsRNA‐independent manner, causing rapid (< 5 min) phosphorylation of eukaryotic initiation factor‐2 α‐subunit (eIF2α). These events resulted in shutting off viral protein translation and blocking viral replication (IC50 = 2 μM) while protecting host cells from virus‐induced damage. Indomethacin did not affect eIF2α kinases PKR‐like endoplasmic reticulum‐resident protein kinase (PERK) and general control non‐derepressible‐2 (GCN2) kinase, and was unable to trigger eIF2α phosphorylation in the presence of PKR inhibitor 2‐aminopurine. In addition, small‐interfering RNA‐mediated PKR gene silencing dampened the antiviral effect in indomethacin‐treated cells. The results identify PKR as a critical target for the antiviral activity of indomethacin and indicate that eIF2α phosphorylation could be a key element in the broad spectrum antiviral activity of the drug.
Alternative Education Options: A Descriptive Study of California Continuation High Schools

Continuation high schools and the students they serve are largely invisible to most Californians. Yet, state school authorities estimate that over 115,000 California high school students will pass through one of the state’s 519 continuation high schools each year, either on their way to a diploma, or to dropping out of school altogether (Austin & Dixon, 2008). 1 Since 1965, state law has mandated that most school districts enrolling over 100 12th grade students make available a continuation program or school that provides an alternative route to the high school diploma for youth vulnerable to academic or behavioral failure. The law provides for the creation of continuation schools ‚designed to meet the educational needs of each pupil, including, but not limited to, independent study, regional occupation programs, work study, career counseling, and job placement services. ‛ It contemplates more intensive services and accelerated credit accrual strategies so that students whose achievement in comprehensive schools has lagged might have a renewed opportunity to ‚complete the required academic courses of instruction to graduate from high school. ‛ 2
Joint Transmitter and Receiver Power Allocation under Minimax MSE Criterion with Perfect and Imperfect CSI for MC-CDMA Transmissions

We investigate the problem of joint transmitter and receiver power allocation with the minimax mean square error (MSE) criterion for uplink transmissions in a multi-carrier code division multiple access (MC-CDMA) system. The objective of power allocation is to minimize the maximum MSE among all users each of which has limited transmit power. This problem is a nonlinear optimization problem. Using the Lagrange multiplier method, we derive the Karush-Kuhn-Tucker (KKT) conditions which are necessary for a power allocation to be optimal. Numerical results indicate that, compared to the minimum total MSE criterion, the minimax MSE criterion yields a higher total MSE but provides a fairer treatment across the users. The advantages of the minimax MSE criterion are more evident when we consider the bit error rate (BER) estimates. Numerical results show that the minimax MSE criterion yields a lower maximum BER and a lower average BER. We also observe that, with the minimax MSE criterion, some users do not transmit at full power. For comparison, with the minimum total MSE criterion, all users transmit at full power. In addition, we investigate robust joint transmitter and receiver power allocation where the channel state information (CSI) is not perfect. The CSI error is assumed to be unknown but bounded by a deterministic value. This problem is formulated as a semidefinite programming (SDP) problem with bilinear matrix inequality (BMI) constraints. Numerical results show that, with imperfect CSI, the minimax MSE criterion also outperforms the minimum total MSE criterion in terms of the maximum and average BERs.
High-dimensional coded matrix multiplication

Coded computation is a framework for providing redundancy in distributed computing systems to make them robust to slower nodes, or stragglers. In [1], the authors propose a coded computation scheme based on maximum distance separable (MDS) codes for computing the product ATB, and this scheme is suitable for the case where one of the matrices is small enough to fit into a single compute node. In this work, we study coded computation involving large matrix multiplication where both matrices are large, and propose a new coded computation scheme, which we call product-coded matrix multiplication. Our analysis reveals interesting insights into which schemes perform best in which regimes. When the number of backup nodes scales sub-linearly in the size of the product, the product-coded scheme achieves the best run-time performance. On the other hand, when the number of backup nodes scales linearly in the size of the product, the MDS-coded scheme achieves the fundamental limit on the run-time performance. Further, we propose a novel application of low-density-parity-check (LDPC) codes to achieve linear-time decoding complexity, thus allowing our proposed solutions to scale gracefully.
The Calpastatin-Derived Calpain Inhibitor CP1B Reduces mRNA Expression of Matrix Metalloproteinase-2 and -9 and Invasion by Leukemic THP-1 Cells

Abstract The ubiquitous proteases u- and m-calpain are Ca2+dependent cysteine endopeptidases. Besides involvement in a variety of physio(patho)logical processes, recent studies suggest a pivotal role of calpains in differentiation of hematopoietic cells and tumor cell invasion. However, the precise actions of calpains and their endogenous inhibitor, calpastatin, in these processes are only partially understood. Here we have studied the role of the calpain/calpastatin system in the invasion of leukemic cells under basal and differentiation-stimulating conditions. To further differentiate the human leukaemic cell line THP-1 (monocytic), the cells were treated for 24 hours with the differentiation-stimulating reagents phorbol 12-myristate 13-acetate (PMA) and dimethyl sulfoxide (DMSO). Macrophage- and granulocyte-like differentiation was confirmed by induction of vimentin expression as well as by microscopic and fluorescence assisted cytometric analysis. Extracellular matrix (ECM) invasion of both the basal and differentiation stimulated cells in a Matrigel assay was inhibited by pre-incubation of the cells with the specific calpain inhibitor CP1B for 24 hours. Inhibition of invasiveness correlated with decreased mRNA expression and secretion of the matrix metalloproteinases MMP-2 and MMP-9. In contrast, addition of CP1B only during the invasion process did neither influence transmigration nor MMP release. This is the first report showing that the calpain/calpastatin system mediates MMP-mRNA expression of the leukemic THP-1 cells and as a consequence their invasiveness.
Transcriptional Phase Variation at the flhB Gene of Pseudomonas putida DOT-T1E Is Involved in Response to Environmental Changes and Suggests the Participation of the Flagellar Export System in Solvent Tolerance

ABSTRACT Frameshift mutations in a poly(G) track at the flhB gene of Pseudomonas putida DOT-T1E are responsible for the diminished swimming of this strain on semisolid medium, which contrasts with the high swimming ability of P. putida KT2440, which does not exhibit a poly(G) track at the flhB gene. We previously showed that a mutant lacking FlhB was more sensitive to solvents than the wild-type strain (Segura et al., J. Bacteriol., 183:4127-4133, 2001). In this study, we show that swimming ability correlates with solvent tolerance in P. putida DOT-T1E, so that growth conditions favoring a functional flhB gene (growth on semisolid medium) resulted in increased innate tolerance to a sudden toluene shock.
Inflammatory cytokines and childhood obstructive sleep apnoea.

OBJECTIVE To evaluate serum cytokine concentrations in children with and without obstructive sleep apnoea (OSA) and to investigate the effects of OSA treatment on cytokines. MATERIALS AND METHODS Consecutive children with habitual snoring and symptoms suggestive of OSA were recruited. They completed a sleep apnoea symptom questionnaire, underwent physical examination and overnight polysomnography (PSG). OSA was diagnosed if obstructive apnoea index (OAI) >1. A blood sample was collected for analysis of IL-6, IL-8, and TNF-alpha after PSG. RESULTS One hundred forty-two children (97 males) with a median (IQR) age of 11.1 years (9.0-12.8) were recruited. The commonest presenting symptoms were nocturnal mouth breathing, prone sleeping position and poor attention at school. Forty-seven children were found to have OSA and they had higher serum IL-6 [0.1 (0.1-0.4) vs 0.1 (0.1-0.1) pg/mL, P = 0.001] and IL-8 [1.7 (1.0-2.3) vs 1.3 (0.9-1.7) pg/mL, P = 0.029] concentrations compared to their non-OSA counterparts. Multiple regression analysis indicated that OAI was significantly associated with both IL-6 (r = 0.351, P <0.001) and IL-8 (r = 0.266, P = 0.002). Sixteen children underwent treatment and there was significant reduction in mean (SD) serum IL-8 after intervention [pre vs post levels of 1.9 (1.0) vs 1.1 (0.6) pg/mL, P = 0.001] independent of weight loss. CONCLUSION Children with OSA had elevated levels of pro-inflammatory cytokines that normalised following treatment suggesting that the inflammatory response is potentially reversible. Early detection and intervention may be beneficial.
To break a coralline: mechanical constraints on the size and survival of a wave-swept seaweed

SUMMARY Previous studies have hypothesized that wave-induced drag forces may constrain the size of intertidal organisms by dislodging or breaking organisms that exceed some critical dimension. In this study, we explored constraints on the size of the articulated coralline alga Calliarthron, which thrives in wave-exposed intertidal habitats. Its ability to survive depends critically upon its segmented morphology (calcified segments separated by flexible joints or `genicula'), which allows otherwise rigid fronds to bend and thereby reduce drag. However, bending also amplifies stress within genicula near the base of fronds. We quantified breakage of genicula in bending by applying known forces to fronds until they broke. Using a mathematical model, we demonstrate the mitigating effect of neighboring fronds on breakage and show that fronds growing within dense populations are no more likely to break in bending than in tension, suggesting that genicular morphology approaches an engineering optimum, possibly reflecting adaptation to hydrodynamic stress. We measured drag in a re-circulating water flume (0.23–3.6 m s–1) and a gravity-accelerated water flume, which generates jets of water that mimic the impact of breaking waves (6–10 m s–1). We used frond Reynolds number to extrapolate drag coefficients in the field and to predict water velocities necessary to break fronds of given sizes. Laboratory data successfully predicted frond sizes found in the field, suggesting that, although Calliarthron is well adapted to resist breakage, wave forces may ultimately limit the size of intertidal fronds.
Using collection descriptions to enhance an aggregation of harvested item-level metadata

As an increasing number of digital library projects embrace the harvesting of item-level descriptive metadata, issues of description granularity and concerns about potential loss of context when harvesting item-level metadata take on greater significance. Collection-level description can provide valuable context for item-level metadata records harvested from disparate and heterogeneous providers. This paper describes an ongoing experiment using collection-level description in concert with item-level metadata to improve quality of search and discovery across an aggregation of metadata describing resources held by a consortium of large academic research libraries. We present details of approaches implemented so far and preliminary analyses of the potential utility of these approaches. The paper concludes with a brief discussion of related issues and future work plans
Genetic links between the acute‐phase response and arthritis development in rats

Abstract Objective The acute‐phase inflammatory response is closely correlated with the development of rheumatoid arthritis, but the pathophysiologic role of its specific components is largely unknown. We investigated the genetic control of the acute‐phase protein response in pristane‐induced arthritis (PIA), which is a chronic erosive arthritis model in rats. Methods Plasma levels of the acute‐phase proteins interleukin‐6 (IL‐6), α1‐acid glycoprotein (orosomucoid), fibrinogen, and α1‐inhibitor3 were quantified in 3 strains of rats during the development and progression of disease: DA and LEW.1F, which are susceptible to arthritis, and E3, which is resistant. Genetic linkage analysis was performed on an F2 intercross between E3 and DA to determine the genetic control of the acute‐phase response in arthritis. Elevated levels of α1‐acid glycoprotein were associated with acute inflammation, whereas levels of IL‐6 were increased during the entire course of the disease. Results Using these acute‐phase markers as quantitative traits in linkage analysis revealed a colocalization of loci controlling the acute‐phase response and regions previously shown to control the development of arthritis in chromosomes 10, 12, and 14. In addition, 2 loci that were not associated with arthritis were found to regulate serum levels of the acute‐phase protein Apr1 (acute‐phase response 1) at the telomeric end of chromosome 12 and Apr2 on chromosome 5. Conclusion The PIA model in rats is a useful tool for understanding some of the pathways leading to chronic erosive arthritis. The analysis of acute‐phase proteins in PIA and its application as quantitative traits for studying the genetics of arthritis will promote the understanding of the genetic regulation of the acute‐phase response.
Monolingually Derived Phrase Scores for Phrase Based SMT Using Neural Networks Vector Representations

In this paper, we propose two new features for estimating phrase-based machine translation parameters from mainly monolingual data. Our method is based on two recently introduced neural network vector representation models for words and sentences. It is the first time that these models have been used in an end to end phrase-based machine translation system. Scores obtained from our method can recover more than 80% of BLEU loss caused by removing phrase table probabilities. We also show that our features combined with the phrase table probabilities improve the BLEU score by absolute 0.74 points.