Miracle-dz/UniFAR-FTUs huggingface dataset:
Distributed core multicast (DCM): a multicast routing protocol for many groups with few receivers

We present a multicast routing protocol called Distributed Core Multicast (DCM). It is intended for use within a large single Internet domain network with a very large number of multicast groups with a small number of receivers. Such a case occurs, for example, when multicast addresses are allocated to mobile hosts, as a mechanism to manage Internet host mobility or in large distributed simulations. For such cases, existing dense or sparse mode multicast routing algorithms do not scale well with the number of multicast groups. DCM is based on an extension of the centre-based tree approach. It uses several core routers, called Distributed Core Routers (DCRs) and a special control protocol among them. DCM aims: (1) avoiding multicast group state information in backbone routers, (2) avoiding triangular routing across expensive backbone links, (3) scaling well with the number of multicast groups. We evaluate the performance of DCM and compare it to an existing sparse mode routing protocol when there is a large number of small multicast groups. We also analyse the behaviour of DCM when the number of receivers per group is not a small number.
Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction. GUSTO-I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) Trial Investigators.

BACKGROUND Ventricular septal defect (VSD) complicating acute myocardial infarction has been studied primarily in small, prethrombolytic-era trials. Our goal was to determine clinical predictors and angiographic and clinical outcomes of this complication in the thrombolytic era. METHODS AND RESULTS We compared enrollment characteristics, angiographic patterns, and outcomes (30-day and 1-year mortality) of patients enrolled in the Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries (GUSTO-I) trial with and without a confirmed diagnosis of VSD. Univariable and multivariable analyses were used to assess relations between enrollment factors and the development of VSD. In all, 84 of the 41 021 patients (0.2%) developed VSD, a smaller percentage than reported in the prethrombolytic era. The median time from symptom onset to VSD diagnosis was 1 day. Enrollment factors most associated with this complication were advanced age, anterior infarction, female sex, and no previous smoking. The infarct artery was more often the left anterior descending and more likely to be totally occluded in patients who developed VSD. Mortality at 30 days was higher in patients with VSDs than in those without this complication (73.8% versus 6.8%, P<0.001). Patients with VSDs selected for surgical repair (n=34) had better outcomes than patients treated medically (n=35; 30-day mortality, 47% versus 94%). CONCLUSIONS Compared with historical control subjects, patients who undergo thrombolysis within 6 hours of infarction onset may have a reduced risk of later VSD. If patients develop this mechanical complication, however, it typically occurs sooner than described in the prethrombolytic era. Despite improvements in medical therapy and percutaneous and surgical techniques, mortality with this complication remains extremely high.
Adaptation in Public and Private Behavior of Ethnic Groups in an American Urban Setting.

This paper addresses itself to the problems of adaptation in both public and private behavior of the ethnic groups in Atlanta and some of the mechanisms that aid in their adaptation to an urban setting. In addition, some problems in applying this information to planning in the city are examined with focus on the role of the anthropologist in action programs. Directions for future research are also briefly explored.
Genetic variation in response to shade in coastal Douglas-fir

Tree improvement programs have generally relied on testing families in open light environments. With increased interest in multiaged silvicultural systems, some people have questioned whether families selected in the open are appropriate for planting in the shade. We grew Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco var. menziesii) families from two climatically distinct seed sources for 2 years under four levels of shade. The response to shade differed for several traits between the two populations and among families within populations. The magnitude of variation associated with the interaction, however, was small compared with the overall effects of genetic selection or of shade. Families selected based on performance in an open light environment resulted in nearly the same response to selection when grown under shade as families selected based on performance in the shade. We conclude that seedlings from families selected in an open light environment are appropriate for use in the low-light environ.
Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum

The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene α-pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic techniques, including high resolution mass spectrum and two-dimentional nuclear magnetic resonance spectroscopic analysis.
Short sleep duration and increased risk of hypertension: a primary care medicine investigation

Objectives: Compelling evidence from laboratory-based and population-based studies link sleep loss to negative cardiovascular health outcomes. However, little is known about the association between sleep duration and hypertension in primary care health settings, independently of other well controlled clinical and biochemical characteristics. We investigated the association between sleep duration and the prevalence of hypertension adjusting for 21 potential confounding factors in a noncontrolled primary care sample. Methods: The sample included 1046 French adults older than 40 years (mean age, 55.5 years), who visited any of the general practitioners of primary care centers in the Paris area. Blood pressure (BP) readings, blood samples and standardized health and sleep questionnaires were performed on each participant. Hypertension inclusion criteria were either high BP measurements (SBP ≥140 mmHg or DBP ≥90 mmHg) or the use of antihypertensive medications. Sleep duration was recorded as the self-reported average number of hours of sleep per night during the week. Logistic regressions were performed to test the association between hypertension and sleep duration adjusted for sociodemographic, clinical, biochemical, lifestyle, psychological and sleep disorder covariates. Results: Compared to the group sleeping 7 h, individuals sleeping 5 h or less had an increased odds ratio (OR) for the prevalence of hypertension [OR = 1.80, 95% confidence interval (1.06–3.05)], after adjusting for 21 potential confounders which did not markedly attenuate this association. Conclusion: Our data provide further epidemiologic evidence that with no specific selection in primary care medicine, usual short-sleep duration increases the risk of hypertension prevalence in adults over 40 years.
Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial

Abstract Objective To determine the impact of a community based Helicobacter pylori screening and eradication programme on the incidence of dyspepsia, resource use, and quality of life, including a cost consequences analysis. Design H pylori screening programme followed by randomised placebo controlled trial of eradication. Setting Seven general practices in southwest England. Participants 10 537 unselected people aged 20-59 years were screened for H pylori infection (13C urea breath test); 1558 of the 1636 participants who tested positive were randomised to H pylori eradication treatment or placebo, and 1539 (99%) were followed up for two years. Intervention Ranitidine bismuth citrate 400 mg and clarithromycin 500 mg twice daily for two weeks or placebo. Main outcome measures Primary care consultation rates for dyspepsia (defined as epigastric pain) two years after randomisation, with secondary outcomes of dyspepsia symptoms, resource use, NHS costs, and quality of life. Results In the eradication group, 35% fewer participants consulted for dyspepsia over two years compared with the placebo group (55/787 v 78/771; odds ratio 0.65, 95% confidence interval 0.46 to 0.94; P = 0.021; number needed to treat 30) and 29% fewer participants had regular symptoms (odds ratio 0.71, 0.56 to 0.90; P = 0.05). NHS costs were £84.70 (£74.90 to £93.91) greater per participant in the eradication group over two years, of which £83.40 ($146; €121) was the cost of eradication treatment. No difference in quality of life existed between the two groups. Conclusions Community screening and eradication of H pylori is feasible in the general population and led to significant reductions in the number of people who consulted for dyspepsia and had symptoms two years after treatment. These benefits have to be balanced against the costs of eradication treatment, so a targeted eradication strategy in dyspeptic patients may be preferable.
Meropenem versus Cefuroxime plus Gentamicin for Treatment of Serious Infections in Elderly Patients

ABSTRACT In this multicenter study, the efficacy of and tolerability for meropenem were compared with those for the combination of cefuroxime-gentamicin (±metronidazole) for the treatment of serious bacterial infections in patients ≥65 years of age. A total of 79 patients were randomized; thirty-nine received meropenem (1 g/8 h), and 40 received cefuroxime (1.5 g/8 h) plus gentamicin (4 mg/kg of body weight daily) for 5 to 10 days. Metronidazole (500 mg/6 h) could be added to the cefuroxime-gentamicin regimen for the treatment of intra-abdominal infections (n = 10). Seventy patients were evaluable for clinical efficacy; the primary diagnoses were as follows: pneumonia in 41 patients (20 treated with meropenem, 21 treated with cefuroxime-gentamicin), intra-abdominal infection in 10 patients (7 meropenem, 3 cefuroxime-gentamicin-metronidazole), urinary tract infection (UTI) in 11 patients (6 meropenem, 5 cefuroxime-gentamicin), sepsis syndrome in 7 patients (4 meropenem, 3 cefuroxime-gentamicin), and “other” in 1 patient (cefuroxime-gentamicin). The pathogens isolated from 18 patients with bacteremia were as follows:Staphylococcus spp. (n = 2),Streptococcus spp. (n = 2), members of the family Enterobacteriaceae (n = 11), and Bacteroides spp. (n = 3). A satisfactory clinical response at the end of therapy was achieved in 26 of 37 (70%) and 24 of 33 (73%) evaluable patients treated with meropenem and combination therapy, respectively. Clinical success was achieved in 23 of 31 (74%) and 21 of 28 (75%) evaluable patients with infections other than UTIs, respectively. A satisfactory microbiological response occurred in 15 of 22 (68%) patients in the meropenem group compared with 12 of 19 (63%) treated with combination therapy. Renal failure occurred during therapy in 2 of 39 (5%) meropenem recipients compared with 5 of 40 (13%) of those treated with combination therapy. The findings in this small study indicate that meropenem is as efficacious for and as well tolerated by elderly patients as the combination of cefuroxime-gentamicin (±metronidazole).
On Convexity of Fairness-Aware Energy-Efficient Power Allocation in Spectrum-Sharing Networks

The optimization of energy efficiency (EE) in spectrum-sharing networks has received increasing attention. While much effort has been devoted to the network-side overall EE, the fairness of EE among users has not been adequately concerned. Due to the complicated interference between different users, the global optimality of power allocation problems for achieving proportional, harmonic, and max-min fair EE with guarantees on users' quality of service has not been fully addressed. By introducing auxiliary variables, changing variables, and transforming the objective and constraint functions, we convert the proportional, harmonic as well as max-min fairness-aware problems to convex ones. As a result, mature algorithms, such as interior-point methods, can be applied to achieve the global optimality with considerable efficiency.
Quality of life and self-report in children and adolescents with cognitive disability

XI CHAPTER 1: INTRODUCTION 1 BACKGROUND 1 THESIS RATIONALE 5 Choice of Research Design 5 Choice of Subjects 6 Choice of Data Collection Methods 7 Choice of Measure 7 Choice of Analysis 8 ORIGINALITY OF THE THESIS 9 THESIS ORGANISATION 10 CHAPTER 2: LITERATURE REVIEW 11
TNF-α-308 G / A polymorphism associated with TNF-α protein expression in patients with diabetic nephropathy

Aims: This study was to clarify the regulated effects of TNF-α -308G/A polymorphism on TNF-α and investigate the relationship of -308G/A polymorphisms with diabetic nephropathy (DN) susceptibility. Methods: 86 DN patients and 94 healthy individuals were enrolled in our study. Polymerase chain reaction-sequence specific primer (PCR-SSP) detection technology was used to testify single nucleotide polymorphism (SNP) of TNF-α gene. Enzymelinked immunosorbent assay (ELISA) was used to measure the content of TNF-α protein. Odds ratio (OR) with 95% CI were used to evaluate the association of TNF-α -308G/A polymorphism and DN susceptibility. Results: The level of TNF-α protein was much higher in DN patients compared to that of controls (P < 0.05). For TNF-α -308G/A, G/A genotype could increase the risk for DN (OR = 2.15, 95% CI = 1.08-4.30). Moreover, a allele frequency was found higher in cases compared with controls, which suggested that A allele served as an genetic-susceptibility factor for DN (OR = 1.89, 95% CI = 1.10-3.26). Further analysis indicated that level of TNF-α for individuals with mutant genotype (GA and AA) were higher than that of individuals with wild genotype (P < 0.05). However, AA genotype showed no effects on DN susceptibility (OR = 2.08, 95% CI = 0.56-7.33). Conclusion: TNF-α-308G/A polymorphism was associated with expression level of TNF-α and served as an genetic-susceptibility factor for DN.
Annual and spatial activity of dung flies and carrion in a Mediterranean holm‐oak pasture ecosystem

The annual activity and spatial distribution of Muscidae and Calliphoridae were investigated in a holm‐oak (‘dehesa’) ecosystem in western Spain over two years in pasture and woodland habitats, using wind‐orientated traps baited with a mixture of fresh cattle faeces, liver and sodium sulphide solution. Lucilia sericata (Meigen) was always the dominant species and, with Chrysomya albiceps (Weidemann), Hydrotaea ignava (Harris), Muscina levida (Harris) and Muscina prolapsa (Harris), was more abundant during the second than the first year. By contrast, Calliphora vicina Robineau‐Desvoidy, Calliphora vomitoria (L.), Hydrotaea armipes (Fallén), Hydrotaea penicillata (Rondani) and Hydrotaea dentipes (Fabricius) were more numerous during the first than the second year of the study. In summer, the Diptera sampled were significantly more abundant in a wooded than a pasture area. However, in autumn, while H. penicillata remained significantly more abundant in woodland, L. sericata became more abundant in the pasture, whereas C. vicina was captured in open and wooded areas in similar proportions. During winter and spring the populations sampled were relatively small. The changing patterns of abundance are discussed in relation to differences in climate within and between years.
Restenosis after successful coronary angioplasty in patients with single-vessel disease.

To determine risk factors for restenosis, we studied 998 patients who underwent elective coronary angioplasty (PTCA) to native coronary arteries between July 1980 and July 1984. Restenosis, defined as a luminal narrowing of greater than 50% at follow-up, was present in 302 patients (30.2%). Univariate analysis of 29 factors revealed seven factors related to restenosis: vessel dilated (circumflex coronary artery 18%, right coronary artery 27%, left anterior descending artery 34%; p less than .01), final gradient of 15 mm Hg or less compared with greater than 15 mm Hg (27% vs 38%, p less than .01), duration of angina greater than 2 months compared with angina of shorter duration (27% vs 35%, p = .01), post-PTCA stenosis of 30% or less compared with 31% to 50% (28% vs 36%, p less than .025), stable vs unstable angina (26% vs 34%, p less than .05), presence vs absence of intimal dissection (26% vs 32%, p = .07), and female gender vs male gender (25% vs 32%, p = .08). Multivariate analysis revealed five factors independently related to increased risk of restenosis in the following order of importance: PTCA in the left anterior descending artery, absence of intimal dissection immediately after PTCA, final gradient greater than 15 mm Hg, a large residual stenosis after PTCA, and unstable angina. Restenosis after PTCA is a multifactorial problem. The hemodynamic and angiographic result at the time of PTCA significantly influences long-term outcome, but additional measures aimed at reducing the rate of recurrence of atherosclerotic plaque are required.
Euphorbia hirta Linn. A wonderful miracle plant of mediterranean region: A review

Euphorbia hirta L. belonging to the family Euphorbiaceae which is frequently seen occupying open waste spaces and grasslands, road sides, and pathways in many parts of the world. The aim of the present study investigation was carried out to compile the medicinal properties of different plant parts of E. hirta L. and to compare their traditional uses with scientific evidences. The leaves of E. hirta are found to contain flavonoids, polyphenols, tannins, sterols, alkaloids, glycosides and triterpenoides. The plant has a reputation for increasing milk flow in women because of its milky latex and is used for other female complaints as well as diseases like bronchitis, asthma, eczema, dysentery. It is used as antidiarrheal, antispasmodic, anti-inflammatory, antifungal, anticancer, antimalarial, antiamoebic, antibacterial and
Purified ryanodine receptor from rabbit skeletal muscle is the calcium- release channel of sarcoplasmic reticulum

The ryanodine receptor of rabbit skeletal muscle sarcoplasmic reticulum was purified as a single 450,000-dalton polypeptide from CHAPS- solubilized triads using immunoaffinity chromatography. The purified receptor had a [3H]ryanodine-binding capacity (Bmax) of 490 pmol/mg and a binding affinity (Kd) of 7.0 nM. Using planar bilayer recording techniques, we show that the purified receptor forms cationic channels selective for divalent ions. Ryanodine receptor channels were identical to the Ca-release channels described in native sarcoplasmic reticulum using the same techniques. In the present work, four criteria were used to establish this identity: (a) activation of channels by micromolar Ca and millimolar ATP and inhibition by micromolar ruthenium red, (b) a main channel conductance of 110 +/- 10 pS in 54 mM trans Ca, (c) a long- term open state of lower unitary conductance induced by ryanodine concentrations as low as 20 nM, and (d) a permeability ratio PCa/PTris approximately equal to 14. In addition, we show that the purified ryanodine receptor channel displays a saturable conductance in both monovalent and divalent cation solutions (gamma max for K and Ca = 1 nS and 172 pS, respectively). In the absence of Ca, channels had a broad selectivity for monovalent cations, but in the presence of Ca, they were selectively permeable to Ca against K by a permeability ratio PCa/PK approximately equal to 6. Receptor channels displayed several equivalent conductance levels, which suggest an oligomeric pore structure. We conclude that the 450,000-dalton polypeptide ryanodine receptor is the Ca-release channel of the sarcoplasmic reticulum and is the target site of ruthenium red and ryanodine.
In Vitro and In Vivo Assessment of Salmonella enterica Serovar Typhimurium DT104 Virulence

ABSTRACT Multidrug-resistant Salmonella enterica serovar Typhimurium phage type DT104 has become a widespread cause of human and other animal infection worldwide. The severity of clinical illness inS. enterica serovar Typhimurium DT104 outbreaks has led to the suggestion that this strain possesses enhanced virulence. In the present study, in vitro and in vivo virulence-associated phenotypes of several clinical isolates of S. enterica serovar Typhimurium DT104 were examined and compared to S. entericaserovar Typhimurium ATCC 14028s. The ability of these DT104 isolates to survive within murine peritoneal macrophages, invade cultured epithelial cells, resist antimicrobial actions of reactive oxygen and nitrogen compounds, and cause lethal infection in mice were assessed. Our results failed to demonstrate that S. enterica serovar Typhimurium DT104 isolates are more virulent than S. enterica serovar Typhimurium ATCC 14028s.
Pedestrian Motion Tracking and Crowd Abnormal Behavior Detection Based on Intelligent Video Surveillance

Pedestrian tracking and detection of crowd abnormal activity under dynamic and complex background us ing I ntelligent V ideo S urveillance (IVS) system are beneficial for security in public places. T his paper present s a pedestrian tracking method combing Histogram of Oriented Gradients (HOG) detection and particle filter . This method regards the particle filter as the tracking framework, identifies the target area according to the result of HOG detection and modifies particle sampling constantly. Our method can track pedestrians in dynamic backgrounds more accurately compared with the traditional particle filter algorithms. Meanwhile, a method to detect crowd abnormal activity is also proposed based on a model of crowd features using Mixture of Gaussian (MOG). This method calculates features of crowd-interest points, then establishes the crowd features model using MOG, conducts self-adaptive updating and detect s a bnormal activity by matching the input feature with model distribution. Experiments show o ur algorithm can efficiently detect abnormal velocity and escape panic in crowds with a high detection rate and a relatively low false alarm rate
The fractured Moon: Production and saturation of porosity in the lunar highlands from impact cratering

We have analyzed the Bouguer anomaly (BA) of ~1200 complex craters in the lunar highlands from Gravity Recovery and Interior Laboratory observations. The BA of these craters is generally negative, though positive BA values are observed, particularly for smaller craters. Crater BA values scale inversely with crater diameter, quantifying how larger impacts produce more extensive fracturing and dilatant bulking. The Bouguer anomaly of craters larger than 93−19+47 km in diameter is independent of crater size, indicating that there is a limiting depth to impact‐generated porosity, presumably from pore collapse associated with either overburden pressure or viscous flow. Impact‐generated porosity of the bulk lunar crust is likely in a state of equilibrium for craters smaller than ~30 km in diameter, consistent with an ~8 km thick lunar megaregolith, whereas the gravity signature of larger craters is still preserved and provides new insight into the cratering record of even the oldest lunar surfaces.