Miracle-dz/UniFAR-FTUs huggingface dataset:
Post-Hospital Discharge Care: A Retrospective Cohort Study Exploring the Value of Pharmacist-Enhanced Care and Describing Medication-Related Problems

BACKGROUND Medication-related problems occur at high rates during care transitions. Evidence suggests that pharmacists are well-suited to identify and resolve medication-related problems during hospital admission and at discharge. Additional evidence is needed to understand the impact of face-to-face pharmacist visits in primary care after discharge. The purpose of the study was to describe medication-related problems found during face-to-face pharmacist visits in a medical home after hospital discharge. METHODS A retrospective cohort study was conducted within an academic primary care center staffed by family medicine trained physicians that evaluated patients who attended a hospital follow-up visit with pharmacist-enhanced care (N = 86) versus usual care (N = 86). The primary objective was to describe medication-related problems identified by pharmacists using a modified individualized Medication Assessment and Planning tool for patients receiving pharmacist-enhanced care. Secondary analyses were also conducted to compare 30-day and 60-day hospital readmission and emergency department visit rates in those exposed to pharmacist-enhanced care versus those who were not. RESULTS At baseline, the mean hospitalizations in the prior year were 1.1 ± 1.7 (pharmacist-enhanced care) and 0.76 ± 1.2 (usual care), indicating a low initial readmission risk. Of patients receiving pharmacist-enhanced care, 97.7% were found to have at least 1 medication-related problem, with an average of 4.36 medication-related problems per patient. The 30-day readmission rate was lower, but not significantly different between groups (8.1% for pharmacist-enhanced care versus 12.8% for usual care; adjusted odds ratio (OR), 0.47; 95% confidence interval (CI), 0.16–1.36). LIMITATIONS Limitations include the retrospective cohort study design and small sample size. Medication-related problems were identified and collected prospectively during pharmacist visits. CONCLUSION Medication-related problems are ubiquitous after hospital discharge. Larger prospective studies will be needed to understand the potential value of pharmacist-enhanced care during hospital follow-up visits on readmission rates in low-risk patient populations receiving care within a primary care medical home.
Analyzing Rural Versus Urban Differences in Career Dissatisfaction and Plans to Leave Among Pennsylvanian Physicians.

PURPOSE This study estimates whether physicians in rural Pennsylvania have higher odds of career dissatisfaction and plans to leave patient care in the next 6 years, compared to their urban counterparts. Rural-urban differences were estimated across specific subgroups of physicians (gender, race, and specialty) and with regard to specific sources of career dissatisfaction. METHODS The 2012 Pennsylvania Health Workforce Survey of Physicians allowed for analysis of 17,444 physicians younger than 55 years old actively practicing patient care. Multivariate, logistic regression was performed to estimate the associations with 2 outcome areas: career dissatisfaction and plans to leave patient care in the next 6 years. Controls included rural setting, age, sex, race, work hours, specialty, and practice characteristics. RESULTS Over 12% of under-55 physicians are dissatisfied with their careers and over 18% report plans to leave patient care in the next 6 years. Rural physicians in Pennsylvania have 18.6% higher odds of reporting career dissatisfaction and 29.5% higher odds of leaving patient care in the next 6 years (P < .01 for each) versus their urban counterparts. CONCLUSIONS Rates of dissatisfaction and potential attrition among younger physicians are not insignificant, with a stronger association with rural practice. Given the large number of rural health shortage areas, better understanding this association is important to health care providers and policy makers. Regression results suggest that higher rural odds are related more to physician work (i.e., stress, practice demands, and lack of autonomy) and family situations and less related to income concerns.
Astrocytic GABA transporter GAT‐1 dysfunction in experimental absence seizures

Enhanced thalamic tonic GABA inhibition plays a role in experimental absence seizures. In this study we investigated astrocytic GABA transporter function and gliotransmitter release in an absence seizure rat model. GAT‐1 GABA transporter currents in thalamic astrocytes were reduced in an absence seizure rat model. Spontaneous phasic astrocytic GABA events displayed kinetic differences between absence seizure model rats and non‐epileptic controls. Spontaneous phasic astrocyte glutamate release was not different in absence seizure model rats and non‐epileptic controls.
Efficacy of the Over-the-Scope Clip System for Treatment of Gastrointestinal Fistulas, Leaks, and Perforations: A Korean Multi-Center Study

Background/Aims Currently, a new over-the-scope clip (OTSC) system has been introduced. This system has been used for gastrointestinal perforations and fistulas in other countries. The aim of our study is to examine the therapeutic success rate of endoscopic treatment using the OTSC system in Korea. Methods This was a multicenter prospective study. A total of seven endoscopists at seven centers performed this procedure. Results A total of 19 patients were included, with gastrointestinal leakages from anastomosis sites, fistulas, or esophageal perforations due to Boerhaave’s syndrome. Among these, there were three gastrojejunostomy sites, three esophagojejunostomy sites, four esophagogastrostomy sites, one esophagocolonostomy site, one jejuno-jejunal site, two endoscopic full thickness resection site closures, one Boerhaave’s syndrome, two esophago-bronchial fistulas, one gastrocolonic fistula, and one colonopseudocyst fistula. The size of the leakage ranged from 5 to 30 mm. The median procedure time was 16 min. All cases were technically successful. Complete closure of the leak was achieved in 14 of 19 patients using OTSC alone. Conclusions The OTSC system is a safe and effective method for the management of gastrointestinal leakage, especially in cases of anastomotic leakage after surgery.
The redox status of coenzyme Q10 in total LDL as an indicator of in vivo oxidative modification. Studies on subjects with familial combined hyperlipidemia.

Familial combined hyperlipidemia (FCH) is characterized by a familial occurrence of a multiple-type hyperlipidemia, associated with coronary risk. The latter may be related to increased levels of small, dense LDL particles that have been found to be more prone to oxidative modification. We isolated total LDL as fresh as possible from 12 normolipidemic relatives with a buoyant LDL subfraction profile (group 1), 7 normolipidemic subjects with a dense LDL subfraction profile (group 2), and 16 hyperlipidemic FCH subjects with a dense LDL subfraction profile (group 3). In these nonobese and normotensive men, we studied the resistance of total LDL against Cu(2+)-oxidation in vitro. In addition, we analyzed the alpha-tocopherol and the coenzyme Q10 contents of LDL and determined their relation to LDL oxidizability. LDL isolated from group 3 subjects was more susceptible to oxidative modification than LDL from group 1 subjects (lag time: 60.4 +/- 8.1 versus 70.4 +/- 11.4 minutes; P < .05). For the combined groups, the ratio of ubiquinol-10 to polyunsaturated fatty acids in LDL, together with the basal amount of dienes in LDL, were good predictors of the rate of LDL oxidation (R2 = .73, P = .0001). In groups 2 and 3, the redox status of coenzyme Q10 (ubiquinol-10/ubiquinone-10) and the ratio of ubiquinol-10 to alpha-tocopherol in LDL were reduced compared with group 1 (P < .05). The K-value a measure of the LDL density, correlated with the the redox status (r = .37, P < .05). We conclude that in subjects with FCH total LDL is more prone to oxidation, due to the predominance of dense LDL particles. In addition, the decreased redox status of coenzyme Q10 in LDL from subjects with a dense LDL subfraction profile suggests that the LDL in the circulation has already undergone some oxidation.
Changing control and accounting in an African gold mine An emergence of a new despotic control

Purpose The paper aims to examine accounting changes in the Ashanti Gold Corporation (AGC) in Ghana over 120 years from pre-colonialism to recent times and whether the framework of management accounting transformations in Hopper et al. (2009) is applicable. Design/methodology/approach Mixed data sources are used, namely, interviews, some observations of practices, historical documentation, company reports and research papers and theses. The results are categorised according to the periods and contextual factors in the Hopper et al. framework to test whether it matches the data collected. Findings Despotic controls with minimal management accounting but stewardship accounting to the head office in London prevailed under colonialism. Upon independence state, capitalist policies descended into politicised state capitalism. Under nationalisation, the performance of mines deteriorated, and accounting became decoupled from operations. In the early 1980s, fiscal crises forced Ghana’s government to turn to the World Bank and International Monetary Fund for loans. This period marked a gradual transformation of AGC into a foreign multinational, organised along divisional lines and currently exercises despotic control through supply chain management that renders labour precarious and is neglectful of corporate social accounting issues. Research limitations/implications The work challenges neo-classical economic prescriptions and analyses of accounting in developed countries by indicating its neglect of the interests of other stakeholders, especially labour and civil society. Accounting is important for development but the article infers other forms may better serve the public interest. Originality/value The paper tests the Hopper et al. framework with respect to a large private multinational in the commodity sector over an extended period, which differs from the case studies drawn on originally.
Behavior Change at the Worksite: Does Social Support Make a Difference?

Purpose. This study examines whether social support for behavior change at work is associated with changes in employee heart disease risk factors. Design. A prospective correlational design was used with data sets collected 12 months apart. Setting. Twenty-five small to medium worksites in Oregon. Subjects. Participants were 689 men and 421 women volunteers who participated in two health assessments at the worksite on company time. Measures. Demographic characteristics, gender, social support, smoking behavior, dietary fat intake, and total blood cholesterol. Results. Employees reporting strong social support at work for not smoking and for limiting dietary fat were less likely to smoke (r = -.11, odds ratio [OR] = .86) and to consume fat in their diets (r = −.10) at baseline. Employees who reported the most change in social support over a 12-month period were most likely to have stopped smoking (r = .15, OR = 1.31). Social support at baseline, however, was unrelated to change in smoking, dietary fat, or total blood cholesterol in a prospective design. Although women reported more social support at work than did men, no differential gender effects of social support were reported on heart disease risk status or change in risk status. Conclusion. Baseline social support at work did not predict future behavior change. The observed association between social support and lifestyle may be better explained as cognitive rationalization than by the impact of social support on behavior.
Cranio-Caudal Kinematic Turn Signature Assessed with Inertial Systems As a Marker of Mobility Deficits in Parkinson’s Disease

Background Turning is a challenging mobility task requiring proper planning, coordination, and postural stability to be executed efficiently. Turn deficits can impair mobility and lead to falls in patients with neurodegenerative disease, such as Parkinson’s disease (PD). It was previously shown that the cranio-caudal sequence involved during a turn (i.e., motion is initiated by the head, followed by the trunk) exhibits a signature that can be captured using an inertial system and analyzed through the Kinematics Theory. The so-called cranio-caudal kinematic turn signature (CCKS) metrics derived from this approach could, therefore, be a promising avenue to develop and track markers to measure early mobility deficits. Objective The current study aims at exploring the discriminative validity and sensitivity of CCKS metrics extracted during turning tasks performed by patients with PD. Methods Thirty-one participants (16 asymptomatic older adults (OA): mean age = 69.1 ± 7.5 years old; 15 OA diagnosed with early PD ON and OFF medication, mean age = 65.8 ± 8.4 years old) performed repeated timed up-and–go (TUG) tasks while wearing a portable inertial system. CCKS metrics (maximum head to trunk angle reached and commanded amplitudes of the head to trunk neuromuscular system, estimated from a sigma-lognormal model) were extracted from kinematic data recorded during the turn phase of the TUG tasks. For comparison purposes, common metrics used to analyze the quality of a turn using inertial systems were also calculated over the same trials (i.e., the number of steps required to complete the turn and the turn mean and maximum velocities). Results All CCKS metrics discriminated between OA and patients (p ≤ 0.041) and were sensitive to change in PD medication state (p ≤ 0.033). Common metrics were also able to discriminate between OA and patients (p < 0.014), but they were unable to capture the change in medication state this early in the disease (p ≥ 0.173). Conclusion The enhanced sensitivity to change of the proposed CCKS metrics suggests a potential use of these metrics for mobility impairments identification and fluctuation assessment, even in the early stages of the disease.
The role of microRNAs in respiratory viral infection: friend or foe?

MicroRNAs (miRNAs) have emerged as a class of regulatory RNAs in host–pathogen interactions. Aberrant miRNA expression seems to play a central role in the pathology of several respiratory viruses, promoting development and progression of infection. miRNAs may thus serve as therapeutic and prognostic factors for respiratory viral infectious disease caused by a variety of agents. We present a comprehensive review of recent findings related to the role of miRNAs in different respiratory viral infections and discuss possible therapeutic opportunities aiming to attenuate the burden of viral infections. Our review supports the emerging concept that cellular and viral‐encoded miRNAs might be broadly implicated in human respiratory viral infections, with either positive or negative effects on virus life cycle. Copyright © 2016 John Wiley & Sons, Ltd.
Bearing Strength and Stiffness of Concrete Under Reinforcing Bars

Results of an experimental investigation on the bearing strength and stiffness of concrete under dowel bars are summarized. The effect of concrete strength, bar diameter, and location of the bar on concrete were studied. Based on test results, empirical equations are proposed to predict the concrete bearing strength and stiffness under reinforcing bars. Comparisons of analytical and experimental results are presented.
Highly efficient electrochemical hydrogen evolution based on nickel diselenide nanowall film

In this letter, we report on hydrothermal growth of nickel diselenide nanowall film on carbon cloth (NiSe2 NW/CC) through topotactic transformation from a Ni(OH)2 precursor based on anion exchange reactions. When tested as an integrated 3D hydrogen-evolving cathode in strongly acidic media, NiSe2 NW/CC exhibits outstanding catalytic activity superior to its powder counterpart and strong long-term durability. It displays 10 and 100 mA cm−2 at overpotentials of 145 and 183 mV, respectively, with its catalytic activity being retained for 40 h.
Lymphatic fluid: exchange mechanisms and regulation

Abstract Regulation of fluid and material movement between the vascular space of microvessels penetrating functioning organs and the cells therein has been studied extensively. Unanswered questions as to the regulatory mechanisms and routes remain. Significantly less is known about the lymphatic vascular system given the difficulties in seeing, no less isolating, these vessels lying deeper in these same tissues. It has become evident that the exchange microvasculature is not simply a passive biophysical barrier separating the vascular and interstitial compartments but a dynamic, multicellular structure subject to acute regulation and chronic adaptation to stimuli including inflammation, sepsis, diabetes, injury, hypoxia and exercise. Similarly lymphatic vessels range, in their simplest form, from lymphatic endothelium attached to the interstitial matrix, to endothelia and phasic lymphatic smooth muscle that act as Starling resistors. Recent work has demonstrated that among the microvascular lymphatic elements, the collecting lymphatics have barrier properties similar to venules, and thus participate in exchange. As with venules, vasoactive agents can alter both the permeability and contractile properties thereby setting up previously unanticipated gradients in the tissue space and providing potential targets for the pharmacological prevention and/or resolution of oedema.
The canonical semantic network supports residual language function in chronic post‐stroke aphasia

Current theories of language recovery after stroke are limited by a reliance on small studies. Here, we aimed to test predictions of current theory and resolve inconsistencies regarding right hemispheric contributions to long‐term recovery. We first defined the canonical semantic network in 43 healthy controls. Then, in a group of 43 patients with chronic post‐stroke aphasia, we tested whether activity in this network predicted performance on measures of semantic comprehension, naming, and fluency while controlling for lesion volume effects. Canonical network activation accounted for 22%–33% of the variance in language test scores. Whole‐brain analyses corroborated these findings, and revealed a core set of regions showing positive relationships to all language measures. We next evaluated the relationship between activation magnitudes in left and right hemispheric portions of the network, and characterized how right hemispheric activation related to the extent of left hemispheric damage. Activation magnitudes in each hemispheric network were strongly correlated, but four right frontal regions showed heightened activity in patients with large lesions. Activity in two of these regions (inferior frontal gyrus pars opercularis and supplementary motor area) was associated with better language abilities in patients with larger lesions, but poorer language abilities in patients with smaller lesions. Our results indicate that bilateral language networks support language processing after stroke, and that right hemispheric activations related to extensive left hemispheric damage occur outside of the canonical semantic network and differentially relate to behavior depending on the extent of left hemispheric damage. Hum Brain Mapp 38:1636–1658, 2017. © 2016 Wiley Periodicals, Inc.
Understanding the Function of Rays and Wood Density on Transverse Fracture Behaviour of Green Wood in Three Species

In recent years, there has been an increasing interest in wood properties, because wood is a commonly used and advanced building material. In this paper, the effect of anatomical characters on the transverse fracture properties of green wood was investigated. The specific fracture energy (Gf J/m) of ash (Fraxinus excelsior), cherry (Prunus avium) and birch (Betula pendula) was evaluated using double edge notched tensile tests. The tests were performed on both earlywood (EW) and latewood (LW) zones in both the radial-tangential (RT) and the tangential-radial (TR) crack propagation systems. Wood anatomy and the failure patterns of each species were also investigated using environmental scanning electron microscopy (ESEM) and light microscopy (LMC). The results showed that the Gf of RT fracture systems was around 1.5 times greater than in the TR one, whereas there were no significant differences between EW and LW zones. ESEM micrographs showed that the RT fracture system had a rougher fracture surface, while the TR had a nearly smooth and flat fracture surface. In particular, the wood of F. excelsior was the toughest, because of its greater percentage of rays and homogenous distribution of ray cells, while P. avium and B. pendula showed a lower Gf due to their smaller percentage of rays with a distinctive arrangement of ray cells.
In and out star formation in z ~ 1.5 quiescent galaxies from rest-frame UV spectroscopy and the far-infrared

We present a sample of 34 spectroscopically confirmed BzK-selected similar to 10(11) M-circle dot quiescent galaxies (pBzK) in the COSMOS field. The targets were initially observed with VIMOS on the VLT to facilitate the calibration of the photometric redshifts of massive galaxies at z greater than or similar to 1.5. Here we describe the reduction and analysis of the data, and the spectrophotometric properties of these pBzK galaxies. In particular, using a spatially resolved median 2D spectrum, we find that the fraction of stellar populations with ages <1 Gyr is at least 3 times higher in the outer regions of the pBzK galaxies than in their cores. This results in a mild age gradient of Delta age <= 0.4 Gyr over similar to 6 kpc and suggests either the occurrence of widespread rejuvenation episodes or that inside- out quenching played a role in the passivization of this galaxy population. We also report on low-level star formation rates derived from the [OII] 3727 angstrom emission line, with SFROII similar to 3.7-4.5 M-circle dot yr (1). This estimate is confirmed by an independent measurement on a separate sample of similarly- selected quiescent galaxies in the COSMOS field, using stacked far-infrared data (SFRFIR similar to 2-4 M-circle dot yr(-1)). This second, photometric sample also displays significant excess at 1.4 GHz, suggestive of the presence of radio-mode AGN activity.
Non-Destructive Infrared Evaluation of Thermo-Physical Parameters in Bamboo Specimens

The estimation of heat conduction properties has considerable importance in the characterization of bamboo with respect to its potential use as an alternative construction material. Even though traditional methods such as hot plates have successfully measured thermal parameters, like thermal diffusivity and conductivity in bamboo samples, it is still necessary to transform the cylindrical bamboo specimen into a piece with special geometry and size. This requirement makes this method impractical in applications where several bamboo specimens need to be measured in their original cylindrical shape. This paper presents the estimation of thermo-physical parameters k and ρ c p in Guadua angustifolia kunth (Guadua a.k.) bamboo through nonlinear least square optimization and infrared thermography. A sensitivity analysis was carried out to determine how the temperature on the bamboo surface is affected by changes in the convection coefficient h, thermal conductivity k, and volumetric heat capacity ρ c p . In spite of the nonlinearity and high correlation in the parameters of the inverse heat conduction problem (IHCP), the estimation of such parameters is robust and consistent with those reported in the literature.