Miracle-dz/UniFAR-FTUs huggingface dataset:
Zipf's Law Leads to Heaps' Law: Analyzing Their Relation in Finite-Size Systems

Background Zipf's law and Heaps' law are observed in disparate complex systems. Of particular interests, these two laws often appear together. Many theoretical models and analyses are performed to understand their co-occurrence in real systems, but it still lacks a clear picture about their relation. Methodology/Principal Findings We show that the Heaps' law can be considered as a derivative phenomenon if the system obeys the Zipf's law. Furthermore, we refine the known approximate solution of the Heaps' exponent provided the Zipf's exponent. We show that the approximate solution is indeed an asymptotic solution for infinite systems, while in the finite-size system the Heaps' exponent is sensitive to the system size. Extensive empirical analysis on tens of disparate systems demonstrates that our refined results can better capture the relation between the Zipf's and Heaps' exponents. Conclusions/Significance The present analysis provides a clear picture about the relation between the Zipf's law and Heaps' law without the help of any specific stochastic model, namely the Heaps' law is indeed a derivative phenomenon from the Zipf's law. The presented numerical method gives considerably better estimation of the Heaps' exponent given the Zipf's exponent and the system size. Our analysis provides some insights and implications of real complex systems. For example, one can naturally obtained a better explanation of the accelerated growth of scale-free networks.
Regeneration of Adult Rat Corticospinal Axons Induced by Transplanted Olfactory Ensheathing Cells

Precisely localized focal stereotaxic electrolytic lesions were made in the corticospinal tract at the level of the first to second cervical segments in the adult rat. This consistently destroyed all central nervous tissue elements (axons, astrocytes, oligodendrocytes, microglia, and microvessels) in a highly circumscribed area. In a group of these rats immediately after lesioning, a suspension of cultured adult olfactory ensheathing cells was transplanted into the lesion site. Within the first week after transplantation, the cut corticospinal axons (identified by anterograde transport of biotin dextran) extended caudally along the axis of the corticospinal tract as single, fine, minimally branched sprouts that ended in a simple tip, often preceded by a small varicosity. By 3 weeks, the regenerating axons, ensheathed by P0-positive peripheral myelin had accumulated into parallel bundles, which now extended across the full length of the lesioned area and reentered the caudal part of the host corticospinal tract. The transplants contained two main types of cells: (1) p75-expressing S cells, which later formed typical peripheral one-to-one myelin sheaths around individual ensheathed axons, and (2) fibronectin-expressing A cells, which aggregated into tubular sheaths enclosing bundles of myelinated axons. The point of reentry of the axons into the central nervous territory of the caudal host corticospinal tract was marked by the resumption of oligodendrocytic myelination. Thus the effect of the transplant was to form a “patch” of peripheral-type tissue across which the cut central axons regenerated and then continued to grow along their original central pathway.
Tpx2, a Novel Xenopus Map Involved in Spindle Pole Organization

TPX2, the targeting protein for Xenopus kinesin-like protein 2 (Xklp2), was identified as a microtubule-associated protein that mediates the binding of the COOH-terminal domain of Xklp2 to microtubules (Wittmann, T., H. Boleti, C. Antony, E. Karsenti, and I. Vernos. 1998. J. Cell Biol. 143:673–685). Here, we report the cloning and functional characterization of Xenopus TPX2. TPX2 is a novel, basic 82.4-kD protein that is phosphorylated during mitosis in a microtubule-dependent way. TPX2 is nuclear during interphase and becomes localized to spindle poles in mitosis. Spindle pole localization of TPX2 requires the activity of the dynein–dynactin complex. In late anaphase TPX2 becomes relocalized from the spindle poles to the midbody. TPX2 is highly homologous to a human protein of unknown function and thus defines a new family of vertebrate spindle pole components. We investigated the function of TPX2 using spindle assembly in Xenopus egg extracts. Immunodepletion of TPX2 from mitotic egg extracts resulted in bipolar structures with disintegrating poles and a decreased microtubule density. Addition of an excess of TPX2 to spindle assembly reactions gave rise to monopolar structures with abnormally enlarged poles. We conclude that, in addition to its function in targeting Xklp2 to microtubule minus ends during mitosis, TPX2 also participates in the organization of spindle poles.
Feature Adaptation Using Linear Spectro-Temporal Transform for Robust Speech Recognition

Spectral information represents short-term speech information within a frame of a few tens of milliseconds, while temporal information captures the evolution of speech statistics over consecutive frames. Motivated by the findings that human speech comprehension relies on the integrity of both the spectral content and temporal envelope of speech signal, we study a spectro-temporal transform framework that adapts run-time speech features to minimize the mismatch between run-time and training data, and its implementation that includes cross transform and cascaded transform. A Kullback-Leibler divergence based cost function is proposed to estimate the transform parameters. We conducted experiments on the REVERB Challenge 2014 task, where clean and multi-condition trained acoustic models are tested with real reverberant and noisy speech. We found that temporal information is important for reverberant speech recognition and the simultaneous use of spectral and temporal information for feature adaptation is effective. We also investigate the combination of the cross transform with fMLLR, the combination of batch, utterance and speaker mode adaptation, and multicondition adaptive training using proposed transforms. All experiments consistently report significant word error rate reductions.
Symptom Recognition and Healthcare Experiences of Young Women With Acute Myocardial Infarction

Background—Prompt recognition of acute myocardial infarction symptoms and timely care-seeking behavior are critical to optimize acute medical therapies. Relatively little is known about the symptom presentation and care-seeking experiences of women aged ⩽55 years with acute myocardial infarction, a group shown to have increased mortality risk as compared with similarly aged men. Understanding symptom recognition and experiences engaging the healthcare system may provide opportunities to reduce delays and improve acute care for this population. Methods and Results—We conducted a qualitative study using in-depth interviews with 30 women (aged 30–55 years) hospitalized with acute myocardial infarction to explore their experiences with prodromal symptoms and their decision-making process to seek medical care. Five themes characterized their experiences: (1) prodromal symptoms varied substantially in both nature and duration; (2) they inaccurately assessed personal risk of heart disease and commonly attributed symptoms to noncardiac causes; (3) competing and conflicting priorities influenced decisions about seeking acute care; (4) the healthcare system was not consistently responsive to them, resulting in delays in workup and diagnosis; and (5) they did not routinely access primary care, including preventive care for heart disease. Conclusions—Participants did not accurately assess their cardiovascular risk, reported poor preventive health behaviors, and delayed seeking care for symptoms, suggesting that differences in both prevention and acute care may be contributing to young women’s elevated acute myocardial infarction mortality relative to men. Identifying factors that promote better cardiovascular knowledge, improved preventive health care, and prompt care-seeking behaviors represent important target for this population.
Stroke unit treatment. 10-year follow-up.

BACKGROUND AND PURPOSE We have previously shown that treatment in our combined acute and rehabilitation stroke unit (SU) improves the outcome during the first 5 years after onset of stroke compared with that for stroke patients treated in general wards (GW). The aim of the present trial was to examine the effects of SU care after 10 years of follow-up. METHODS In a randomized controlled trial, 110 patients with symptoms and signs of an acute stroke were allocated to the SU and 110 to GW. No significant differences existed in baseline characteristics between the groups. The outcome after 10 years was measured by the proportion of patients at home, the proportion of patients in an institution, the mortality, and the functional state as assessed by the Barthel Index, in which a Barthel Index score of >/=60 was classified as independent or partly independent and a score of >/=95 was classified as independent. RESULTS After 10 years, 21 (19.1%) of the patients randomized to the SU and 9 (8.2%) of the patients randomized to the GW were at home (P=0.0184). Eighty-three (75.5%) of the patients from the SU and 96 (87.3%) of the patients from the GW were dead (P=0.0082), and 6 (5.4%) and 5 (4.5%), respectively, were in an institution (eg, nursing home; NS). Twenty-two (20.0%) of the SU patients and 9 (8. 2%) of the GW patients had a Barthel Index score of >/=60 (P=0.0118), and 14 (12.7%) and 6 (5.4%), respectively, had a score of >/=95 (P=0.0606). CONCLUSIONS For the first time it has been shown that SU care improves survival and functional state and increases the proportion of patients able to live at home 10 years after their stroke. Treatment in combined acute and rehabilitation SU seems to have important long-term effects on outcome for stroke patients.
Carbon monoxide and hospital admissions for congestive heart failure: evidence of an increased effect at low temperatures.

The combined effects of carbon monoxide and low temperature on daily variation in hospital admissions for congestive heart failure (CHF) were examined for a 4-year period in Chicago, Illinois. Medicare hospital admissions for CHF were analyzed as a function of the maximum hourly temperature, maximum hourly levels of carbon monoxide (CO), and other criteria pollutants in Chicago for each day of the 4-year period (1986-1989). The regression analyses for the time series were conducted using single and multipollutant models with interaction terms and adjustments for weather, weekly cycles, seasonal effects, and secular trend. The data were also grouped into three temperature ranges, <40 degrees, 40 degrees-75 degrees, and >75 degrees F, and the relationship between CO and CHF admissions was evaluated for each range. For the 4-year time series, the CO level was positively associated with hospital admissions for CHF in the single pollutant and multipollutant models after adjustment for seasonal effects and weather pattern. The relative risks of hospital admissions for CHF in Chicago associated with the 75th percentile of exposure to CO in the high, medium, and low temperature ranges were 1.02 [95% confidence interval (CI), 0.95-1.10], 1.09 (CI, 1.04-1.14), and 1.15 (CI, 1.09-1.22), respectively. In these data, the effect of CO on hospital admissions for CHF was temperature dependent, with the magnitude of the effect increasing with decreasing temperature. This synergy may help to explain the association between ambient CO and CHF admissions demonstrated in other studies. ImagesFigure 1Figure 2Figure 3
Genetic parameters of slaughter and carcase traits in Japanese quail (Coturnix coturnix japonica)

1. Genetic parameters of slaughter and carcase traits were estimated for 5-week-old Japanese quail reared under the one-to-one sire and dam pedigree recorded system. Data were analysed using restricted maximum likelihood (REML) with relationship matrix. Records of 1244 animals from 119 sires and 156 dams were analysed. 2. An individual animal model was used which had the animals’ genetic effect as the only random factor. Heritability and standard errors of slaughter, cold carcase, breast, leg, wing, others, liver weights and dressing percentage were 0·40 ± 0·07, 0·55 ± 0·07, 0·58 ± 0·07, 0·54 ± 0·07, 0·49 ± 0·07, 0·42 ± 0·06, 0·13 ± 0·04 and 0·21 ± 0·05 respectively. Moderate to high heritability for most of the studied traits suggested that selection to increase or decrease these traits will be successful. 3. The strongest genetic correlation was found between slaughter, carcase and breast weights (0·97–0·87). These high genetic correlations provide an opportunity to select for breast weight on the basis of 5-week weight. 4. It can be concluded that carcase weight and 5-week weight of quail can be included in a selection index to increase the weights of valuable carcass parts.
Supplemental Information Reprogramming of T Cells from Human Peripheral Blood

Supplemental Experimental Procedures Production of virus. Cell culture and human iPS cell induction. Donor blood cells collection and isolation. Immunohistochemistry staining. qRT–PCR. Global gene expression. Bisulfite genomic sequencing. DNA fingerprinting and karyotyping. Embryoid body formation. Hematopoietic colony-forming assays. Assay for teratoma formation. Flow cytometry. Southern Blot analysis.
Ferroelectric Properties of Chemically Synthesized Perovskite BiFeO3-PbTiO3 Thin Films

In this study, we investigated the solid solution of BiFeO<sub>3</sub>-PbTiO<sub>3</sub> (BF-PT) system to improve the structural stability of perovskite phase and to enhance of several properties by using a morphotropic phase boundary (MPB) composition. Perovskite BF-PT single phase thin films were successfully fabricated though the formation of solid solution with PbTiO<sub>3</sub>. Although the electrical resistivity of BF-PT thin films was not sufficiently high at around room temperature, the large ferroelectricity was observed at low temperatures. The 0.7BiFeO<sub>3</sub>-0.3PbTiO<sub>3</sub> thin films exhibited the P<sub>r</sub> value of 60 muC/cm<sup>2</sup> at -190degC.
What can the Real World do for simulation studies? A comparison of exploratory methods

For simulation studies on the exploratory factor analysis (EFA), usually rather simple population models are used without model errors. In the present study, real data characteristics are used for Monte Carlo simulation studies. Real large data sets are examined and the results of EFA on them are taken as the population models. First we apply a resampling technique on these data sets with sub samples of different sizes. Then, a Monte Carlo study is conducted based on the parameters of the population model and with some variations of them. Two data sets are analyzed as an illustration. Results suggest that outcomes of simulation studies are always highly influenced by particular specification of the model and its violations. Once small residual correlations appeared in the data for example, the ranking of our methods changed completely. The analysis of real data set characteristics is therefore important to understand the performance of different methods.
Support vector machines for robust channel estimation in OFDM

A new support vector machine (SVM) algorithm for coherent robust demodulation in orthogonal frequency-division multiplexing (OFDM) systems is proposed. We present a complex regression SVM formulation specifically adapted to a pilots-based OFDM signal. This novel proposal provides a simpler scheme than an SVM classification method. The feasibility of our approach is substantiated by computer simulation results obtained for IEEE 802.16 broadband fixed wireless channel models. These experiments allow to scrutinize the performance of the OFDM-SVM system and the suitability of the epsiv-Huber cost function, in the presence of non-Gaussian impulse noise interfering with OFDM pilot symbols
Dietary intake and resting energy expenditure in relation to weight loss in unselected cancer patients

Weight loss and anorexia are frequent findings in advanced cancer. The progressive wasting could be attributed to changes in dietary intake and/or energy expenditure mediated by metabolic alterations. In this study, we analyzed dietary intake in generalized malignant disease of solid tumor type in relation to resting energy expenditure (REE) and reported weight loss. In a group of 297 unselected cancer patients from a university hospital outpatient clinic, dietary intake of energy and macronutrients from a 4‐day food record, REE by indirect calorimetry, height, weight and weight loss were recorded. Protein intake was validated against 24 hr urine nitrogen in a subgroup (n = 53), and no indication of systematic misreporting was found. Mean daily dietary intake was below maintenance requirements, 26 ± 10 kcal/kg. Weight loss of more than 10% was present in 43% of patients and elevated REE (>110% of predicted) in 48%. Dietary intake did not differ between normo‐ and hypermetabolic patients, nor was tumour type or gender related to energy and protein intake. Weight loss could not be accounted for by diminished dietary intake since energy intake in absolute amounts was not different and intake per kilogram body weight was higher in weight‐losing patients compared to weight‐stable patients. Dietary macronutrient composition did not differ from the general population. Dietary intake of energy and protein was decreased, but dietary macronutrient composition did not appear to be changed. Weight loss and hypermetabolism were frequent and not compensated for by an increase in spontaneous food intake. Our results indicate that an expected up‐regulation of dietary intake in response to elevated energy expenditure is frequently lost in cancer patients. This may be the explanation behind cancer cachexia rather than a primary decrease in appetite. © 2001 Wiley‐Liss, Inc.
Vertical graphene by plasma-enhanced chemical vapor deposition: Correlation of plasma conditions and growth characteristics

Vertically aligned graphene was grown by plasma-enhanced chemical vapor deposition using methane feedstock. Optical emission spectroscopy (OES) was used to monitor the plasma species, and Raman spectroscopy was used for characterizing the properties of as-grown vertically aligned graphene. OES-derived information on plasma species, such as C, C_2, CH, and H, are correlated with the properties of the vertically aligned graphene. Graphene grown at 250 W and 15 sccm exhibited the lowest amount of defects. Although OES peak intensities occurred at the highest power and lowest flow conditions, the OES peak ratios of plasma species had a greater dependence on flow rate and exhibited a saddle point in the atomic C/H ratio corresponding to optimal growth involving the lowest amount of overall defects. Plasma diagnostics provides a valuable approach to optimize growth characteristics and material properties.
The Minimal Robust Positively Invariant Set for Linear Difference Inclusions and its Robust Positively Invariant Approximations

Robust positively invariant (RPI) sets for linear difference inclusions are considered here under the assumption that the linear difference inclusion is absolutely asymptotically stable in the absence of additive state disturbances, which is the case for parametrically uncertain or switching linear discrete-time systems controlled by a stabilizing linear state feedback controller. The existence and uniqueness of the minimal RPI set and the minimal convex RPI set are studied. A new method for the computation of outer RPI approximations of the minimal RPI set for linear difference is presented; these approximations include a family of star–shaped RPI sets and two families of convex RPI sets. The use of a family of star–shaped RPI sets, and the characterization of the family, is reported for the first time. Keyword: Set invariance, Minimal Robust Positively Invariant Set, Linear Difference Inclusions
Role of Biological Agents in Immune-mediated Inflammatory Diseases

A new era in the treatment of immune-mediated inflammatory disorders has begun with the clinical availability of anticytokine therapy. Biological agents that are currently available include 3 agents that decrease the activity of tumor necrosis factor-α (infliximab, adalimumab, etanercept) and an interleukin-1 receptor antagonist (anakinra), with many more in development. Those extraordinarily effective medications are an important addition to our therapeutic armamentarium, and, although originally developed for rheumatoid arthritis and Crohn disease, have been found to be efficacious in the treatment of seronegative spondyloarthropathies (psoriatic arthritis, ankylosing spondylitis) and juvenile rheumatoid arthritis. Their role is currently being defined in other autoimmune disorders such as uveitis, sarcoidosis, interstitial lung disease, vasculitis, inflammatory myopathies, graft-versus-host disease, and Sjögren syndrome.
Sociomateriality and learning: a critical approach

This chapter provides an introduction to perspectives that may be described as ‘sociomaterial’, discussing their premises and examples in educational research. These perspectives have been influenced by a range of theoretical families including actor-network theory and sociotechnical studies, complexity theory, new feminist materialisms, poststructural geographies, and others. The main premise they share is that there are no clear, inherent distinctions between social phenomena and materiality. Everyday practice is constituted through entangled social and material forces that continually assemble and reassemble. Objects, events, identities and knowledge are understood to be performed into being through these social and material relations. Effects such as capacity and ‘skill’ are understood to be distributed, not located as agency within human beings. One task for analysts is to trace just how these relations work: how human and more-than-human forces act upon one another in ways that mutually transform their characteristics and activity, how they produce assemblages that become stabilized, and sometimes become extended and powerful. Examples from research in education show how materials actively influence learning and teaching practices, how learning itself is a material matter, and how educational processes are in fact temporary sociomaterial achievements.
Development of pregnancy in rats treated with Hypericum perforatum

St John's wort (Hypericum perforatum) is a medicinal plant used in the treatment of depression and other psychiatric disorders. In the present paper, the toxicity of H. perforatum administered to female rats during the period of organogenesis (day 9–15 of pregnancy) was evaluated. Thirty inseminated Wistar rats were randomly distributed into control and treated groups, which received, by gavage, 0.5 mL of saline and 36 mg/kg body weight of Jarsin dried extract diluted into 0.5 mL of saline, respectively. Maternal toxicity was evaluated through: water and food intake, body weight gain, piloerection, locomotor activity, diarrhea and death occurrence. Animals were killed on day 21 of pregnancy, when fetuses and placentas were removed and weighed. The indices of implantation and resorption were calculated. Clinical signs of maternal toxicity were not observed and none of the variables analysed showed statistically significant differences. In the dose administered in the experimental model used, H. perforatum does not seem to be toxic to the mother nor to interfere with the progress of gestation during organogenesis. Copyright © 2005 John Wiley & Sons, Ltd.