Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of the 7th and 8th editions of the American joint committee on cancer TNM classification for patients with stage III gastric cancer.

BACKGROUND AND OBJECTIVES The eighth TNM edition for gastric cancer was released in 2016 and included major revisions, especially of stage III. The purpose of this study was to evaluate the prognostic value of the new AJCC TNM classification in comparison with the 7th edition for stage III gastric cancer. METHODS Clinical and histopathological data on 1,496 patients operated on for stage III GC according to the seventh edition between 2005 and 2013 were analyzed and compared using 7th and 8th classifications. The 2 systems were compared in terms of prognostic performance. RESULTS The stage shifted for 650 (43.45%) patients: from IIIA to IIIB (2 patient, 0.13%), from IIIB to IIIA (214 patients, 14.30%), from IIIB to IIIC (99 patients, 6.62%), and from IIIC to IIIB (335 patients, 22.39%). Cox regression multivariate analysis showed both the 8th and 7th TNM classification were independent prognostic factors. The 8th edition system had higher linear trend and likelihood ratio χ2 scores, and smaller AIC values compared with those for the 7th edition. However, the performance of the eighth edition did not reveal significant improvement compared to the seventh edition (c-index 0.625 vs. c-index 0.616, p=0.085). CONCLUSION The eighth TNM edition may not provide significantly better accuracy in predicting the prognosis of stage III GC. However, to confirm our findings, further studies are warranted.
Comparison of lifestyle in fertile and infertile couples in Kermanshah during 2013

Background: Infertility is a major reproductive health in gynecology. According to the world health organization, there are currently 50-80 million infertile couples in the world. Objective: Considering the critical effects of lifestyle on reproductive health, this study aimed to compare the lifestyle of fertile and infertile couples in Kermanshah during 2013. Materials and Methods: This research is a descriptive cross sectional study that was done on 216 fertile and infertile couples attending Infertility Center and six medical centers that were selected through the convenience sampling. Data were collected using a researcher-made questionnaire containing demographic and fertility-related information and also lifestyle items on nutrition, physical activity, perceived social support, responsibility for health, and inappropriate health behaviors. Descriptive statistics, logistic regression analysis, independent t, chi-square and Generalized Estimating equation were performed to analyze the data. Results: Fertile and infertile women (86.1% and 73. 1% respectively, p= 0. 03) as well as fertile and infertile men were significantly different in terms of physical activity (87% and 96.3% p<0.001, respectively) and perceived social support (p<0.001). Moreover, there was a significant difference between fertile and infertile women in nutrition (p<0.001). Similar differences were observed in responsibility for health and inappropriate health behaviors between fertile and infertile men. However, all of the dimensions of lifestyle, except nutrition, were significantly different between fertile and infertile couples. Conclusion: As lifestyle plays a crucial role in reproductive health, the inappropriate lifestyle of infertile couples has to be modified through effective measures such as awareness promotion, behavioral changes, and development of a healthy environment.
Traffic surveillance from a safety perspective: an ITS data application

Reactive traffic management strategies such as incident detection are becoming less relevant with the advancement of mobile phone usage. Freeway management in the 21st century needs to shift focus toward proactive strategies that include anticipating incidents such as the crashes. "Predicting" crash occurrences would also be the key to traffic safety. A two-step approach to identify freeway locations with high probability of crashes through real-time traffic surveillance data is presented here. For this study historical crash and corresponding traffic data from loop detectors were gathered from a 58-km (36-mile) corridor of Interstate-4. Following an exploratory analysis two types of logistic regression models, i.e., simple and multivariate, were developed. The simple models were used to deduce time-space patterns of variation in crash risk while the multivariate model was chosen for final classification of traffic patterns. As a suggested application for the simple models, their output may be used for preliminary assessment of the crash risk. If there is an indication of high crash risk then the multivariate model may be employed to explicitly classify the data patterns as leading or not-leading to crash occurrence. A demonstration of this two-stage real-time application strategy is also provided in the paper.
Resveratrol levels and all-cause mortality in older community-dwelling adults.

IMPORTANCE Resveratrol, a polyphenol found in grapes, red wine, chocolate, and certain berries and roots, is considered to have antioxidant, anti-inflammatory, and anticancer effects in humans and is related to longevity in some lower organisms. OBJECTIVE To determine whether resveratrol levels achieved with diet are associated with inflammation, cancer, cardiovascular disease, and mortality in humans. DESIGN Prospective cohort study, the Invecchiare in Chianti (InCHIANTI) Study ("Aging in the Chianti Region"), 1998 to 2009 conducted in 2 villages in the Chianti area in a population-based sample of 783 community-dwelling men and women 65 years or older. EXPOSURES Twenty-four-hour urinary resveratrol metabolites. MAIN OUTCOMES AND MEASURES Primary outcome measure was all-cause mortality. Secondary outcomes were markers of inflammation (serum C-reactive protein [CRP], interleukin [IL]-6, IL-1β, and tumor necrosis factor [TNF]) and prevalent and incident cancer and cardiovascular disease. RESULTS Mean (95% CI) log total urinary resveratrol metabolite concentrations were 7.08 (6.69-7.48) nmol/g of creatinine. During 9 years of follow-up, 268 (34.3%) of the participants died. From the lowest to the highest quartile of baseline total urinary resveratrol metabolites, the proportion of participants who died from all causes was 34.4%, 31.6%, 33.5%, and 37.4%, respectively (P = .67). Participants in the lowest quartile had a hazards ratio for mortality of 0.80 (95% CI, 0.54-1.17) compared with those in the highest quartile of total urinary resveratrol in a multivariable Cox proportional hazards model that adjusted for potential confounders. Resveratrol levels were not significantly associated with serum CRP, IL-6, IL-1β, TNF, prevalent or incident cardiovascular disease, or cancer. CONCLUSIONS AND RELEVANCE In older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, or cancer or predictive of all-cause mortality. Resveratrol levels achieved with a Western diet did not have a substantial influence on health status and mortality risk of the population in this study.
Do not resuscitate status, not age, affects outcomes after injury: An evaluation of 15,227 consecutive trauma patients

BACKGROUND: Despite a well‐described association of age and injury with mortality and decreased functional status, inpatient mortality studies have traditionally not included analysis of do not resuscitate (DNR) status. We hypothesized that the increased likelihood of DNR status in older patients alters age‐adjusted mortality rates in trauma. METHODS: The trauma registry was queried for adult patients admitted to our Level I trauma center (January 2005–December 2008) and divided into eight age groups by decade. Ages 15–44 years were collapsed because of the lack of variation. We compared age, case fatality rate, and DNR status by univariate analysis and trends by [chi]2 (p < 0.05). RESULTS: Of the 15,227 adult patients admitted, 13% were elderly (>=65) and 7% died. DNR status was known in 75% of deaths, and 42% of those had active DNR orders on the chart at time of death. DNR likelihood increased with age (p < 0.05), from 5% to 18%. With DNRs excluded, mortality variability across all ages was markedly diminished (4–7%). CONCLUSION: DNR status among trauma patients varies significantly because of inconsistent implementation and meaning between hospitals, and successive decades are more likely to have an active DNR order at time of death. When DNR patients were excluded from mortality analysis, age was minimally associated with an increased risk of death. The inclusion of DNR patients within mortality studies likely skews those analyses, falsely indicating failed resuscitative efforts rather than humane decisions to limit care after injury. LEVEL OF EVIDENCE: Prognostic and epidemiologic study, level IV.
Liver Resection for Hepatocellular Carcinoma Major Hepatic Resection May Suppress the Growth of Tumours Remaining in the Residual Liver

(HCC), which is one of the most common malignant tumours, is still considered as the most radical treatment. Recent advances in surgical techniques for hepatectomy have made surgical intervention a safe and effective treatment for HCC. However, even if the resection is curative, recurrences in the remaining liver frequently occur (Nagao et al, 1990; Yamamoto et al, 1996). Once such recurrences are found, the patient prognosis is poor. In reality, the overall 5 year survival rate of patients with HCC after curative resection has been reported to exceed fifty per cent (Kosuge et al, 1993). Therefore, the prevention of recurrences is important for patients with HCC, however the mechanisms of such recurrences remain unclear. When HCC patients are operated upon, intra-operative manipulation should be as careful as possible in order not to mechanically disperse any possible cancer cells (Ezaki et al, 1989). Despite such careful manipulation, residual microscopic HCC cells undetected by pre-operative imaging for diagnosis, can cause recurrences (Utsunomiya et al, 1992). Other investigators have shown that most recurrent tumours occurred predominantly in the remaining liver near the primary lesion rather than in distant segments (Nagao et al, 1990; Yamamoto et al, 1996). Further, most secondary tumours in the remaining liver after the first hepatic resection were considered to be caused by metastatic recurrence and not by secondary carcinogenesis, the so-called 'multicentric occurrence' (Shimada et al, 1998). These reports allow us to speculate that the most likely causes of HCC recurrence may be due to: (a) the cancer cells dispersed by intra-operative manipulation and (b) existence of HCC in the remaining liver following curative resection, which is the established tumour undetected pre-operatively. Several experiments for acceleration of intra-hepatic tumour growth by partial hepatectomy in animal models have been trying to prove how cancer cells are distributed in the liver following hepatectomy in conjunction with the above explanation (a) However, it is still controversial as to whether partial hepatic resection renders progression or regression of tumour cells (Ono et al, 1986; Castillo et al, 1989). The different timing of hepatectomy before or after administration of different tumour cell lines, via different routes, may cause inconsistent results for these experimental studies. Additionally, very few studies have reported the effect of hepatectomy on established HCC in the residual liver as outlined above in point (b). In the present study using an intra-hepatic tumour implantation model, the effects of hepatic resection on the …
Take a stand on understanding: electrophysiological evidence for stem access in German complex verbs

The lexical representation of complex words in Indo-European languages is generally assumed to depend on semantic compositionality. This study investigated whether semantically compositional and noncompositional derivations are accessed via their constituent units or as whole words. In an overt visual priming experiment (300 ms stimulus onset asynchrony, SOA), event-related potentials (ERPs) were recorded for verbs (e.g., ziehen, “pull”) that were preceded by purely semantically related verbs (e.g., zerren, “drag”), by morphologically related and semantically compositional verbs (e.g., zuziehen, “pull together”), by morphologically related and semantically noncompositional verbs (e.g., erziehen, “educate”), by orthographically similar verbs (e.g., zielen, “aim”), or by unrelated verbs (e.g., tarnen, “mask”). Compared to the unrelated condition, which evoked an N400 effect with the largest amplitude at centro-parietal recording sites, the N400 was reduced in all other conditions. The rank order of N400 amplitudes turned out as follows: morphologically related and semantically compositional ≈ morphologically related and semantically noncompositional < purely semantically related < orthographically similar < unrelated. Surprisingly, morphologically related primes produced similar N400 modulations—irrespective of their semantic compositionality. The control conditions with orthographic similarity confirmed that these morphological effects were not the result of a simple form overlap between primes and targets. Our findings suggest that the lexical representation of German complex verbs refers to their base form, regardless of meaning compositionality. Theories of the lexical representation of German words need to incorporate this aspect of language processing in German.
Epigenetic Mechanism Underlying the Development of Polycystic Ovary Syndrome (PCOS)-Like Phenotypes in Prenatally Androgenized Rhesus Monkeys

The pathogenesis of polycystic ovary syndrome (PCOS) is poorly understood. PCOS-like phenotypes are produced by prenatal androgenization (PA) of female rhesus monkeys. We hypothesize that perturbation of the epigenome, through altered DNA methylation, is one of the mechanisms whereby PA reprograms monkeys to develop PCOS. Infant and adult visceral adipose tissues (VAT) harvested from 15 PA and 10 control monkeys were studied. Bisulfite treated samples were subjected to genome-wide CpG methylation analysis, designed to simultaneously measure methylation levels at 27,578 CpG sites. Analysis was carried out using Bayesian Classification with Singular Value Decomposition (BCSVD), testing all probes simultaneously in a single test. Stringent criteria were then applied to filter out invalid probes due to sequence dissimilarities between human probes and monkey DNA, and then mapped to the rhesus genome. This yielded differentially methylated loci between PA and control monkeys, 163 in infant VAT, and 325 in adult VAT (BCSVD P<0.05). Among these two sets of genes, we identified several significant pathways, including the antiproliferative role of TOB in T cell signaling and transforming growth factor-β (TGF-β) signaling. Our results suggest PA may modify DNA methylation patterns in both infant and adult VAT. This pilot study suggests that excess fetal androgen exposure in female nonhuman primates may predispose to PCOS via alteration of the epigenome, providing a novel avenue to understand PCOS in humans.
EFFECTS OF MICROHABITAT AND MICROCLIMATE SELECTION ON ADULT SURVIVORSHIP OF THE LESSER PRAIRIE-CHICKEN

Abstract Populations of the lesser prairie-chicken (Tympanuchus pallidicinctus), an endemic grouse of the south-central United States, have declined precipitously. This species occurs in short- and mixed-grass prairies with sandy soils. Apart from perennial grasses of short stature, prairie-chicken habitat is characterized by dryland shrubs of the sand shinnery community, particularly the shinnery oak (Quercus havardii) and sand sagebrush (Artemisia filifolia). We measured microhabitat and microclimate characteristics at bird-centered and random points at the southwestern (New Mexico) and northeastern (Oklahoma) edges of the species' range. We estimated survival by locating radio-tagged prairie-chickens (n = 544) from April 1999 to June 2003. We found that lesser prairie-chickens used sites within the sand shinnery community that had a higher cover and greater density of shrubs (ANOVA: P < 0.0001). Microclimate differed substantially between occupied and random sites (MANOVA: P < 0.0001), and prairie-chicken survival was higher in microhabitat that was cooler, more humid, and less exposed to the wind. Survivorship was higher for adults that chose microhabitat with a higher cover of shrubs and grasses and a higher density of vegetation. Survivorship was higher for prairie-chickens that used sites with >20% cover of shrubs than for those choosing 10–20% cover; in turn, survivorship was higher for prairie-chickens choosing 10–20% cover than for those choosing <10% cover (Cox regression: P < 0.05). Whereas vegetation may recover following moderate habitat disturbance, land managers applying herbicides or otherwise removing shrubs should understand the potentially negative effects of reduced shrub cover on adult survivorship of lesser prairie-chickens.
Interactive relighting of dynamic refractive objects

We present a new technique for interactive relighting of dynamic refractive objects with complex material properties. We describe our technique in terms of a rendering pipeline in which each stage runs entirely on the GPU. The rendering pipeline converts surfaces to volumetric data, traces the curved paths of photons as they refract through the volume, and renders arbitrary views of the resulting radiance distribution. Our rendering pipeline is fast enough to permit interactive updates to lighting, materials, geometry, and viewing parameters without any precomputation. Applications of our technique include the visualization of caustics, absorption, and scattering while running physical simulations or while manipulating surfaces in real time.
Clinical study of a monophasic pill containing 20 microg ethinylestradiol and 150 microg desogestrel in Thai women.

OBJECTIVES To evaluate the contraceptive reliability and clinical effects of a monophasic oral contraceptive containing 20 microg ethinylestradiol and 150 microg desogestrel (Mercilon) in Thai women. METHOD The study was carried out at the Family Planning Clinic of King Chulalongkorn Memorial Hospital, Bangkok, Thailand. One hundred and forty six healthy women of fertile age were enrolled and treated with the study oral contraceptives for 12 cycles. Clinical data of vaginal bleeding, side effects, blood pressure and body weight were assessed periodically. RESULTS One thousand four hundred and twenty five cycles were evaluated. No conception occurred. The cycles were almost regular. The incidence of irregular bleeding was highest in the first cycle, after the third cycle, the value was below 4 per cent. Side effects were very few. There was no change in blood pressure. A slight decrease in mean body weight was observed. CONCLUSION The oral contraceptive containing 20 microg ethinylestradiol and 150 microg desogestrel has high contraceptive efficacy, good cycle control and minimal side effects.
Distribution and Variability of Satellite‐Derived Signals of Isolated Convection Initiation Events Over Central Eastern China

This study combined measurements from the Chinese operational geostationary satellite Fengyun‐2E (FY‐2E) and ground‐based weather radars to conduct a statistical survey of isolated convection initiation (CI) over central eastern China (CEC). The convective environment in CEC is modulated by the complex topography and monsoon climate. From May to August 2010, a total of 1,630 isolated CI signals were derived from FY‐2E using a semiautomated method. The formation of these satellite‐derived CI signals peaks in the early afternoon and occurs with high frequency in areas with remarkable terrain inhomogeneity (e.g., mountain, water, and mountain‐water areas). The high signal frequency areas shift from northwest CEC (dry, high altitude) in early summer to southeast CEC (humid, low altitude) in midsummer along with an increasing monthly mean frequency. The satellite‐derived CI signals tend to have longer lead times (the time difference between satellite‐derived signal formation and radar‐based CI) in the late morning and afternoon than in the early morning and night. During the early morning and night, the distinction between cloud top signatures and background terrestrial radiation becomes less apparent, resulting in delayed identification of the signals and thus short and even negative lead times. A decline in the lead time is observed from May to August, likely due to the increasing cloud growth rate and warm‐rain processes. Results show increasing lead times with increasing landscape elevation, likely due to more warm‐rain processes over the coastal sea and plain, along with a decreasing cloud growth rate from hill and mountain to the plateau.
Characterizing Post-Glossectomy Speech Using Real-time MRI

We use real-time magnetic resonance imaging (rtMRI) as a tool to investigate post-glossectomy speech by examining articulatory behavior. Our data reveal that listeners perceive speech produced by postoperative partial-glossectomy patients whose surgical procedure most affected the base of tongue to be typical, while speech produced by patients whose procedure affected the oral tongue is perceived to be atypical. Mechanisms of both preservation and compensation are exhibited by post-glossectomy patients whose speech is deemed atypical by listeners. These patients employ the preservative behavior of maintaining durational differences in tense and lax vowels, as well as range of F1 (vowel height). Range of F2 (vowel backness), however, is severely reduced. Compensatory behavior is exhibited when coronal tongue movement has been impeded and is exemplified by (i) production of labial stops in place of target coronal stops and laterals and (ii) frication being produced by formation of a constriction between the tongue dorsum and palate, in place of alveolar fricative /s/.
Clarifying Search: A User-Interface Framework for Text Searches

Current user interfaces for textual database searching leave much to be desired: individually, they are often confusing, and as a group, they are seriously inconsistent. We propose a four- phase framework for user-interface design: the framework provides common structure and terminology for searching while preserving the distinct features of individual collections and search mechanisms. Users will benefit from faster learning, increased comprehension, and better control, leading to more effective searches and higher satisfaction.