Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient and health care professional perspectives on using telehealth to deliver pulmonary rehabilitation

The objective of this study was to identify the necessary features of pulmonary telerehabilitation (P-TR) from the perspectives of individuals living with chronic lung disease and health care professionals (HCPs) who deliver pulmonary rehabilitation (PR). Focus groups were carried out with patients (n = 26) and HCPs (n = 26) to elicit and explore their opinions about the critical elements of in-person PR and ideas for how these elements could be supported using technology. A questionnaire was used to assess technology use, PR experience, and general health status. Four key elements of PR were identified as critical to P-TR: the social aspect of PR; communicating with HCPs for education and support; using biosensors for monitoring and promoting self-knowledge; and the evolution of support with progress over time. A range of technology-enabled devices and programs were suggested as means to recreate aspects of these integral elements. Consultations with patients and HCPs suggest that users are interested in technology and want to ensure it recreates the important aspects of PR. Patients and HCPs identified similar key elements for P-TR. The opinions and suggestions of patients and HCPs should be the driving force of innovation if P-TR is to succeed in improving health outcomes.
Extraction yields and anti-oxidant activity of proanthocyanidins from different parts of grape pomace: effect of mechanical treatments.

INTRODUCTION White grape pomace is not subject to maceration, keeping nearly all polyphenols of grapes, so they represent important sources of bioactive compounds such as proanthocyanidins. Preparation of plant polyphenol extracts is usually performed using raw material powder. However, the fine particles make the further extraction procedure steps more difficult. OBJECTIVE To study the effect of mechanical treatments on extraction yields and anti-oxidant activity from different parts of white grape pomace. METHODS Skins, stems and seeds were isolated from the pomace of white winemaking process. Sequential solvent extraction of polyphenols, first using 80% methanol in water followed by 75% acetone in water, was carried out on both entire and milled (< 1 mm) grape solids; extraction on seed polyphenols was also performed in its squashed form. The phenolic content of each extract was verified by spectrometric and HPLC methods and its anti-oxidant activity was evaluated by the 1,1-diphenyl-2-picrylhydrazyl test. RESULTS More total polyphenols can be extracted from each milled tissue than from its entire form. Seeds present the highest total phenol, oligomeric and polymeric proanthocyanidin content, and similar extraction yield was found between milled and squashed tissues. The HPLC analysis showed no difference in extraction yield of low-molecular-weight proanthocyanidins between milled and entire stems. Anti-oxidant activity showed a positive correlation with total phenol content, galloyled oligomers and polymeric proanthocyanidins. CONCLUSION The use of entire stems and squashed seeds for solvent extraction of polyphenols makes manipulation simpler and more cost-efficient, providing similar extraction yields to using their powdery forms.
Ethanol extract of Hedyotis diffusa willd upregulates G0/G1 phase arrest and induces apoptosis in human leukemia cells by modulating caspase cascade signaling and altering associated genes expression was assayed by cDNA microarray

The authors' previous study has shown that water extract of Hedyotis diffusa Willd (HDW) promoted immune response and exhibited anti‐leukemic activity in BALB/c leukemic mice in vivo. In this study, the anti‐proliferation effects of ethanol extract of H. diffusa Willd (EEHDW) on lung cancer cell lines (A549, H1355, and LLC), leukemia cell lines (HL‐60, WEHI‐3), and a mouse melanoma cell line (B16F10) in vitro were investigated. The results demonstrated that EEHDW suppressed the cell proliferation of A549, H1355, HL‐60, WEHI‐3, and B16F10 cells as well as reduced cell viability in a concentration‐dependent manner. We found that EEHDW inhibited the cell proliferation of HL‐60 cells in concentration‐dependent manner. In addition, EEHDW triggered an arrest of HL‐60 cells at G0/G1 phase and sub‐G1 population (apoptotic cells). EEHDW provoked DNA condensation and DNA damage in HL‐60 cells. The activities of caspase‐3, caspase‐8, and caspase‐9 were elevated in EEHDW‐treated HL‐60 cells. DNA microarray to investigate and display the gene levels related to cell growth, signal transduction, apoptosis, cell adhesion, cell cycle, DNA damage and repair, transcription and translation was also used. These findings suggest that EEHDW may be a potential herbal medicine and therapeutic agent for the treatment of leukemia. © 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 1162–1177, 2015.
Set similarity search beyond MinHash

We consider the problem of approximate set similarity search under Braun-Blanquet similarity B(x, y) = |x ∩ y| / max(|x|, |y|). The (b1, b2)-approximate Braun-Blanquet similarity search problem is to preprocess a collection of sets P such that, given a query set q, if there exists x Ε P with B(q, x) ≥ b1, then we can efficiently return x′ Ε P with B(q, x′) > b2. We present a simple data structure that solves this problem with space usage O(n1+ρlogn + ∑x ε P|x|) and query time O(|q|nρ logn) where n = |P| and ρ = log(1/b1)/log(1/b2). Making use of existing lower bounds for locality-sensitive hashing by O'Donnell et al. (TOCT 2014) we show that this value of ρ is tight across the parameter space, i.e., for every choice of constants 0 < b2 < b1 < 1. In the case where all sets have the same size our solution strictly improves upon the value of ρ that can be obtained through the use of state-of-the-art data-independent techniques in the Indyk-Motwani locality-sensitive hashing framework (STOC 1998) such as Broder's MinHash (CCS 1997) for Jaccard similarity and Andoni et al.'s cross-polytope LSH (NIPS 2015) for cosine similarity. Surprisingly, even though our solution is data-independent, for a large part of the parameter space we outperform the currently best data-dependent method by Andoni and Razenshteyn (STOC 2015).
Preserved Neural Event Segmentation in Healthy Older Adults

An important feature of action understanding is that comprehenders segment the perceptual stream into events. Event segmentation dynamically engages a network of brain regions that likely play a role in how events are encoded. Here, in a sample of older adults, we assessed the relationship between changes in brain dynamics during movie watching and event understanding performance. Forty healthy older adults and a comparison sample of 12 younger adults passively viewed short movies of everyday activities while their brain activity was measured with fMRI. Afterward, they segmented the movies into events and performed memory tasks for movie content. The older adults engaged a similar event segmentation network during movie watching as the younger adults. Individual differences analyses revealed that although behavioral measures of event segmentation predicted memory, activity in the segmentation network did not. Intersubject correlation analyses revealed that normative brain dynamics during viewing in the right posterior temporal sulcus and left dorsolateral prefrontal cortex predicted better segmentation performance. These data suggest that these regions play an important role in event understanding, and also that the event segmentation network is preserved in healthy aging.
Development of Children's Use of External Reminders for Hard-to-Remember Intentions.

This study explored under what conditions young children would set reminders to aid their memory for delayed intentions. A computerized task requiring participants to carry out delayed intentions under varying levels of cognitive load was presented to 63 children (aged between 6.9 and 13.0 years old). Children of all ages demonstrated metacognitive predictions of their performance that were congruent with task difficulty. Only older children, however, set more reminders when they expected their future memory performance to be poorer. These results suggest that most primary school-aged children possess metacognitive knowledge about their prospective memory limits, but that only older children may be able to exercise the metacognitive control required to translate this knowledge into strategic reminder setting.
Structural Displacement Measurement Using an Unmanned Aerial System

Vibration‐based Structural Health Monitoring (SHM) is one of the most popular solutions to assess the safety of civil infrastructure. SHM applications all begin with measuring the dynamic response of structures, but displacement measurement has been limited by the difficulty in requiring a fixed reference point, high cost, and/or low accuracy. Recently, researchers have conducted studies on vision‐based structural health monitoring, which provides noncontact and efficient measurement. However, these approaches have been limited to stationary cameras, which have the challenge of finding a location to deploy the cameras with appropriate line‐of‐sight, especially to monitor critical civil infrastructures such as bridges. The Unmanned Aerial System (UAS) can potentially overcome the limitation of finding optimal locations to deploy the camera, but existing vision‐based displacement measurement methods rely on the assumption that the camera is stationary. The displacements obtained by such methods will be a relative displacement of a structure to the camera motion, not an absolute displacement. Therefore, this article presents a framework to achieve absolute displacement of a structure from a video taken from an UAS using the following phased approach. First, a target‐free method is implemented to extract the relative structural displacement from the video. Next, the 6 degree‐of‐freedom camera motion (three translations and three rotations) is estimated by tracking the background feature points. Finally, the absolute structural displacement is recovered by combining the relative structural displacement and the camera motion. The performance of the proposed system has been validated in the laboratory using a commercial UAS. Displacement of a pinned‐connected railroad truss bridge in Rockford, IL subjected to revenue‐service traffic loading was reproduced on a hydraulic simulator, while the UAS was flown from a distance of 4.6 m (simulating the track clearance required by the Federal Railroad Administration), resulting in estimated displacements with an RMS error of 2.14 mm.
Energy-Efficient Hybrid Transceiver Designs for Millimeter Wave Communication Systems

In this paper, we consider the design of low-complexity analog-digital hybrid transceivers for a multi-input multi- output (MIMO) millimeter wave (mmWave) communication system operating in a $K-$user interference channel. Our objective is to achieve the energy efficiency by minimizing overall transmit power required for achieving a target mean- square error (MSE) at the receivers. We propose two transceiver designs based on the quality of the available channel state information (CSI). We first present a design that minimizes total transmit power assuming the availability of perfect channel knowledge. Later, we extend it to a robust transceiver design by considering imperfections in CSI. The proposed designs achieve reduced hardware and computational complexity by forming hybrid architecture using sparse signal processing. Hence, achieving similar MSE with lower energy consumption. We evaluate the performance of both the proposed schemes based on various parameters. Furthermore, we demonstrate the resilience of the robust design in presence of errors in CSI and performance of both the designs with various dictionaries.
Effect of body size on the abundance of ectoparasitic mites on the wild rodent Oligoryzomys nigripes

Abstract The abundance of parasites on a host can be affected by several factors; in this study, we investigated the influence of sex and body size of the host rodent Oligoryzomys nigripes on the abundance of ectoparasitic mites (Acari: Mesostigmata). The generalized linear model indicated that body size (indicative of age) of the host rodent O. nigripes significantly contributed to the variation in the abundance of mites on host rodents at the Experimental Station of Itirapina. This trend of increased parasitism on hosts with larger body sizes may be linked to the fact that larger individuals are able to support the coexistence of a larger number of parasites, and being more mobile, are more exposed to infection by parasites.
Analyzing Large-Scale Multiuser Molecular Communication via 3-D Stochastic Geometry

Information delivery using chemical molecules is an integral part of biology at multiple distance scales and has attracted recent interest in bioengineering and communication theory. Potential applications include cooperative networks with a large number of simple devices that could be randomly located (e.g., due to mobility). This paper presents the first tractable analytical model for the collective signal strength due to randomly placed transmitters in a 3-D large-scale molecular communication system, either with or without degradation in the propagation environment. Transmitter locations in an unbounded and homogeneous fluid are modeled as a homogeneous Poisson point process. By applying stochastic geometry, analytical expressions are derived for the expected number of molecules absorbed by a fully absorbing receiver or observed by a passive receiver. The bit error probability is derived under ON/OFF keying and either a constant or adaptive decision threshold. Results reveal that the combined signal strength increases proportionately with the transmitter density, and the minimum bit error probability can be improved by introducing molecule degradation. Furthermore, the analysis of the system can be generalized to other receiver designs and other performance characteristics in large-scale molecular communication systems.
Reliability of Estimation Pile Load Capacity Methods

None of numerous previous methods for predicting pile capacity is known how accurate any of them are when compared with the actual ultimate capacity of piles tested to failure. The author’s of the present paper have conducted such an analysis, based on 130 data sets of field loading tests. Out of these 130 data sets, only 44 could be analysed, of which 15 were conducted until the piles actually reached failure. The pile prediction methods used were: Brinch Hansen’s method (1963), Chin’s method (1970), Decourt’s Extrapolation Method (1999), Mazurkiewicz’s method (1972), Van der Veen’s method (1953), and the Quadratic Hyperbolic Method proposed by Lastiasih et al. (2012). It was obtained that all the above methods were sufficiently reliable when applied to data from pile loading tests that loaded to reach failure. However, when applied to data from pile loading tests that loaded without reaching failure, the methods that yielded lower values for correction factor N are more recommended. Finally, the empirical method of Reese and O’Neill (1988) was found to be reliable enough to be used to estimate the Qult of a pile foundation based on soil data only.
Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response

Inflammation is typically induced in response to a microbial infection. The release of proinflammatory cytokines enhances the stimulatory capacity of antigen-presenting cells, as well as recruits adaptive and innate immune effectors to the site of infection. Once the microbe is cleared, inflammation is resolved by various mechanisms to avoid unnecessary tissue damage. Autoimmunity arises when aberrant immune responses target self-tissues causing inflammation. In type 1 diabetes (T1D), T cells attack the insulin producing β cells in the pancreatic islets. Genetic and environmental factors increase T1D risk by in part altering central and peripheral tolerance inducing events. This results in the development and expansion of β cell-specific effector T cells (Teff) which mediate islet inflammation. Unlike protective immunity where inflammation is terminated, autoimmunity is sustained by chronic inflammation. In this review, we will highlight the key events which initiate and sustain T cell-driven pancreatic islet inflammation in nonobese diabetic mice and in human T1D. Specifically, we will discuss: (i) dysregulation of thymic selection events, (ii) the role of intrinsic and extrinsic factors that enhance the expansion and pathogenicity of Teff, (iii) defects which impair homeostasis and suppressor activity of FoxP3-expressing regulatory T cells, and (iv) properties of β cells which contribute to islet inflammation.
Selection of induction therapy in kidney transplantation

Currently available immunosuppressive agents can be classified into three categories: induction agents, maintenance therapy, and treatment for rejection. This review article will focus on induction immunosuppression. There are three antibodies which are used for induction therapy: the lymphocyte‐depleting agents – anti‐thymocyte globulin and alemtuzumab, and basiliximab which is nondepleting. Historically, immunosuppressant selection was solely based on efficacy for prevention of rejection. In the current era of transplantation, it is now common practice in the transplant community to select induction therapy on the basis of risk–benefit considerations for each patient. This article will focus on the efficacy of available induction agents and the selection of induction agent based on donor and recipient risk factors.
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox

High molecular weight homologues of gp91phox, the superoxide-generating subunit of phagocyte nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, have been identified in human (h) and Caenorhabditis elegans (Ce), and are termed Duox for “dual oxidase” because they have both a peroxidase homology domain and a gp91phox domain. A topology model predicts that the enzyme will utilize cytosolic NADPH to generate reactive oxygen, but the function of the ecto peroxidase domain was unknown. Ce-Duox1 is expressed in hypodermal cells underlying the cuticle of larval animals. To investigate function, RNA interference (RNAi) was carried out in C. elegans. RNAi animals showed complex phenotypes similar to those described previously in mutations in collagen biosynthesis that are known to affect the cuticle, an extracellular matrix. Electron micrographs showed gross abnormalities in the cuticle of RNAi animals. In cuticle, collagen and other proteins are cross-linked via di- and trityrosine linkages, and these linkages were absent in RNAi animals. The expressed peroxidase domains of both Ce-Duox1 and h-Duox showed peroxidase activity and catalyzed cross-linking of free tyrosine ethyl ester. Thus, Ce-Duox catalyzes the cross-linking of tyrosine residues involved in the stabilization of cuticular extracellular matrix.
Natural selection on MHC IIβ in parapatric lake and stream stickleback: Balancing, divergent, both or neither?

Major histocompatibility complex (MHC) genes encode proteins that play a central role in vertebrates' adaptive immunity to parasites. MHC loci are among the most polymorphic in vertebrates' genomes, inspiring many studies to identify evolutionary processes driving MHC polymorphism within populations and divergence between populations. Leading hypotheses include balancing selection favouring rare alleles within populations, and spatially divergent selection. These hypotheses do not always produce diagnosably distinct predictions, causing many studies of MHC to yield inconsistent or ambiguous results. We suggest a novel strategy to distinguish balancing vs. divergent selection on MHC, taking advantage of natural admixture between parapatric populations. With divergent selection, individuals with immigrant alleles will be more infected and less fit because they are susceptible to novel parasites in their new habitat. With balancing selection, individuals with locally rare immigrant alleles will be more fit (less infected). We tested these contrasting predictions using three‐spine stickleback from three replicate pairs of parapatric lake and stream habitats. We found numerous positive and negative associations between particular MHC IIβ alleles and particular parasite taxa. A few allele–parasite comparisons supported balancing selection, and others supported divergent selection between habitats. But, there was no overall tendency for fish with immigrant MHC alleles to be more or less heavily infected. Instead, locally rare MHC alleles (not necessarily immigrants) were associated with heavier infections. Our results illustrate the complex relationship between MHC IIβ allelic variation and spatially varying multispecies parasite communities: different hypotheses may be concurrently true for different allele–parasite combinations.
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis of several neurodegenerative diseases. Mutations in the gene encoding SOD1 (superoxide disumutase 1) trigger familial amyotrophic lateral sclerosis (ALS), inducing its misfolding and aggregation and the progressive loss of motoneurons. It is still under debate whether autophagy has a protective or detrimental role in ALS. Here we evaluate the impact of BECN1/Beclin 1, an essential autophagy regulator, in ALS. BECN1 levels were upregulated in both cells and animals expressing mutant SOD1. To evaluate the impact of BECN1 to the pathogenesis of ALS in vivo, we generated mutant SOD1 transgenic mice heterozygous for Becn1. We observed an unexpected increase in life span of mutant SOD1 transgenic mice haploinsufficient for Becn1 compared with littermate control animals. These effects were accompanied by enhanced accumulation of SQSTM1/p62 and reduced levels of LC3-II, and an altered equilibrium between monomeric and oligomeric mutant SOD1 species in the spinal cord. At the molecular level, we detected an abnormal interaction of mutant SOD1 with the BECN1-BCL2L1 complex that may impact autophagy stimulation. Our data support a dual role of BECN1 in ALS and depict a complex scenario in terms of predicting the effects of manipulating autophagy in a disease context.