Miracle-dz/UniFAR-FTUs huggingface dataset:
Service responses to South Asian women who attempt suicide or self-harm: challenges for service commissioning and delivery

This article draws on an investigation of service responses to women of South Asian background who have attempted suicide or self-harm within northwest England to outline policy challenges for adequate provision to this population. This article highlights, in particular, the challenges for service managers arising from and documented within the study, outlining implications for improving policy, service commissioning and provision. We suggest that these omissions have resulted in the distress of South Asian women going unrecognized in the name of respect for cultural diversity, thereby sanctioning policies and practices that further the oppression of South Asian women. Four main issues emerging from the interviews are discussed: 1) the impact of the contract culture on the form and structure of service provision; 2) limitations of current partnership arrangements with South Asian communities; 3) practical and conceptual problems within models of both consultation and change; and, 4) key practical consequences of the covert ways in which the structure and interpretation of service responses work to treat `race' as more important than gender. In terms of specific implications, it is suggested that the current policy focus on addressing service inequalities via recruitment of South Asian workers warrants critical re-evaluation, while training and management development should take as central the intersections of `race', culture, class and gender as systemic issues to be worked with rather than marginal or optional considerations. It is argued that attending to the specific needs and conditions of South Asian women attempting suicide or self-harm by providing integrated culturally and gender-sensitive services highlights good practice for everyone.
Managerial and Customer Costs of Price Adjustment: Direct Evidence from Industrial Markets

We study the price adjustment practices and provide quantitative measurement of the managerial and customer costs of price adjustment using data from a large U.S. industrial manufacturer and its customers. We find that price adjustment costs are a much more complex construct than the existing industrial-organization or macroeconomics literature recognizes. In addition to physical costs (menu costs), we identify and measure three types of managerial costs (information gathering, decision-making, and communication costs) and two types of customer costs (communication and negotiation costs). We find that the managerial costs are more than 6 times, and customer costs are more than 20 times, the menu costs. In total, the price adjustment costs comprise 1.22 of the company's revenue and 20.03 of the company's net margin. We show that many components of the managerial and customer costs are convex, whereas the menu costs are not. We also document the link between price adjustment costs and price rigidity. Finally, we provide evidence of managers' fear of antagonizing customers. I have no answer to the question of how to measure these menu change costs, but these menu cost theories will never be taken seriously until an answer is provided. Edward Prescott (1987, p. 113) Given the large number of theoretical papers that evaluate the implications of price adjustment costs, obtaining direct evidence that such costs are present seems crucial. Margaret Slade (1998, p. 104)
New insights into the allergic march

Purpose of review The allergic march of childhood describes an association between atopic dermatitis, IgE-mediated food allergy, allergic asthma, and allergic rhinitis that begins with an atopic family history. This review summarizes recent insights into the nature of these conditions and their associations. Recent findings In recent years, common allergic diseases have become more prevalent and increased rates of food allergies remain incompletely understood. This review explores a newly described major genetic risk factor, a mutation in the skin matrix protein filaggrin, as it relates to the allergic march of childhood. New paradigms of understanding the interrelationships between atopic dermatitis, food allergy, and asthma are described. A surge of investigative effort has been directed toward the prevention and treatment of food allergy. Risk factors for allergic asthma in young children have been used to predict patient response to treatment. A recent practice parameter on furry animal/pet avoidance updates current understanding of allergen avoidance in modifying allergic phenotypes. Summary Understanding of the interrelationships of atopic diseases allows earlier diagnosis of allergic conditions in at-risk patient populations and may lead to novel approaches to health promotion and disease prevention.
Students' Probabilistic Thinking in Instruction.

In this study we evaluated the thinking of 3rd-grade students in relation to an instructional program in probability. The instructional program was informed by a researchbased framework that included a description of students' probabilistic thinking. Both an earlyand a delayed-instruction group participated in the program. Qualitative evidence from 4 target students revealed that overcoming a misconception in sample space, applying both part-part and part-whole reasoning, and using invented language to describe probabilities were key patterns in producing growth in probabilistic thinking. Moreover, 51% of the students exhibited the latter 2 learning patterns by the end of instruction, and both groups displayed significant growth in probabilistic thinking following the intervention.
We Really Do Know What You Do: A Comparison of Reports from 11 Year Olds and their Parents in Respect of Parental Economic Activity and Occupation:

It is widely assumed that children, especially younger children and those in poorer circumstances, are unreliable informants of parental occupation and related characteristics, thereby precluding the measurement of social class in much research involving children. In a comparison of reports of parental economic activity and occupation by 11 year olds and their parents in the West of Scotland 11 to 16 Study, the assumption is found to be unwarranted. This school-based study, which used a 'mini-interview' to question children about parental characteristics, found lower levels of missing data among children compared to parents and '(very) good' levels of agreement (as indicated by the Kappa statistic) about both economic activity and occupation. These results, which were similar for boys and girls and those in different material and family circumstances, also suggest that children may sometimes provide more valid reports than parents themselves. Under particular fieldwork conditions, therefore, children as young as 11 from diverse social backgrounds can provide reliable, and possibly very valid, reports of parental socio-economic characteristics. With few additional resources, most studies of child only informants could reproduce that study's fieldwork procedures to obtain good data on social class.
Lens induction by Pax-6 in Xenopus laevis.

Despite extensive study following the pioneering work of Spemann on lens development (Spemann, H. (1901) Verh. Anat. Ges. 15, 61-79) and the subsequent establishment of the concept of embryonic induction, the molecular mechanism of vertebrate lens induction remains largely unknown. Here we report that in Xenopus expression of Pax-6 results in lens formation in a cell autonomous manner. In animal cap experiments, Pax-6 induced expression of the lens-specific marker beta B1-crystallin without inducing the general neural marker NCAM. Ectopic Pax-6 expression also resulted in the formation of ectopic lenses in whole embryos as well as in animal cap explants indicating that in vertebrates, as well as Drosophila (Halder, G., Callaerts, P., and Gehring, W.J. (1995) Science 267, 1788-1792), Pax-6 can direct the development of major components of the eye. Interestingly, ectopic lenses formed in whole embryos without association with neural tissue. Treatments giving rise to anterior neural tissue in animal cap explants resulted in the expression of both beta B1-crystallin and Pax-6. Given the ability of Pax-6 to direct lens formation, we propose that the establishment of Pax-6 expression in the presumptive lens ectoderm during normal development is likely to be a critical response of lens-competent ectoderm to early lens inducers.
A Model-based Study of Relationship between Timing of Second Heart Sound and Systolic Blood Pressure

The onset of second heart sound is triggered by the closure of aortic valve due to the interaction of left ventricle and arterial system. Noninvasive experiments found that RS2 defined by the time delay from the peak of ECG R wave to the onset of the second heart sound had a close inverse correlation with arterial systolic blood pressure. However, no theoretical study has been carried out to investigate the underline connections between them. A modified model of heart-arterial system is proposed in the present study. In this model the heart is described as a pressure source depending on time, ventricular volume, outflow, and heart rate, and the arterial system as a nonlinear system incorporating a pressure-dependent compliance. Simulation results show that the modified model is able to reflect the cardiovascular function qualitatively. The results also demonstrate that RS2 is inversely correlated with aortic blood pressure under the effect of changing peripheral resistance, heart rate and contractility. The present study gives insight into the significant functional relations between the parameters characterizing the cardiovascular system and hemodynamics characteristics and provides an interpretation of the experimental observation on the relationship between RS2 and aortic blood pressure
Glomerular Atrial Natriuretic Factor Receptors in Spontaneously Hypertensive Rats

There are differences in the renal handling of sodium between spontaneously hypertensive rats (SHR) and their normotensive controls. We investigated whether this difference may be associated with changes in plasma and tissue atrial natriuretic factor (ANF) levels and with alterations in glomerular ANF receptors at 4, 8, 12, and 16 weeks of age. Age-matched Wistar-Kyoto (WKY) and Wistar rats were used as normotensive controls. Systolic blood pressure was higher in SHR at 8, 12, and 16 weeks, and cardiac hypertrophy was also present in these animals at 4 weeks. Plasma ANF C- and N-terminal concentrations were greater than in both normotensive groups at 8 and 16 weeks. ANF in the right atrium was higher in SHR than in WKY rats and identical to that in the Wistar group at 4 and 8 weeks. ANF in the left atrium was lower in SHR than in both control groups at week 12. No differences were found in ventricular ANF content. The density of glomerular ANF binding sites increased with age in WKY and Wistar rats but not in SHR. At weeks 8, 12, and 16, both normotensive groups had a higher density of binding sites than SHR, but binding site affinity was greater in SHR at weeks 8 and 12. After incubation with increasing concentrations of ANF, the production of cyclic guanosine monophosphate (cGMP) by isolated glomeruli from 16-week-old rats was lower in SHR than in both normotensive groups. We conclude that the development of hypertension in SHR is associated with higher plasma ANF levels and decreased glomerular ANF receptor density and glomerular cGMP production. Through modulation of ANF glomerular receptors, ANF in SHR, when compared with normotensive counterparts, may contribute to the difference in renal sodium handling.
Genomic profiling of lung adenocarcinoma patients reveals therapeutic targets and confers clinical benefit when standard molecular testing is negative

Background: Identification of clinically relevant oncogenic drivers in advanced cancer is critical in selecting appropriate targeted therapy. Using next-generation sequencing (NGS)-based clinical cancer gene assay, we performed comprehensive genomic profiling (CGP) of advanced cases of lung adenocarcinoma. Methods: Formalin-fixed paraffin-embedded tumors from 51 lung adenocarcinoma patients whose tumors previously tested negative for EGFR/KRAS/ALK by conventional methods were collected, and CGP was performed via hybridization capture of 4,557 exons from 287 cancer-related genes and 47 introns from 19 genes frequently rearranged in cancer. Results: Genomic profiles of all 51 cases were obtained, with a median coverage of 564x and a total of 190 individual genomic alterations (GAs). GAs per specimen was a mean of 3.7 (range 0-10). Cancer genomes are characterized by 50% (80/190) non-synonymous base substitutions, 15% (29/190) insertions or deletion, and 3% (5/190) splice site mutation. TP53 mutation was the most common GAs (15%, n=29/190), followed by CDKN2A homozygous loss (5%, n=10/190), KRAS mutation (4%, n=8/190), EGFR mutation (4%, n=8/190) and MDM2 amplification (2%, n=5/190). As per NCCN guidelines, targetable GAs were identified in 16 patients (31%) (BRAF mutation [n=1], EGFR mutation [n=8], ERBB2 mutation [n=4], MET amplification [n=1], KIF5B-RET rearrangement [n=2], CCDC6-RET rearrangement [n=1], CD74-ROS1 rearrangement [n=1], EZR-ROS1 rearrangement [n=5], and SLC34A2-ROS1 rearrangement [n=1]). Conclusion: Fifty eight percent of patients wild type by standard testing for EGFR/KRAS/ALK have GAs identifiable by CGP that suggest benefit from target therapy. CGP used when standard molecular testing for NSCLC is negative can reveal additional avenues of benefit from targeted therapy.
Promoting preventive behaviors against influenza: Comparison between developing and developed countries

Applying the health belief model, this study examined young adults' intention to adopt preventive behaviors against influenza infection in developing countries (Thailand and Cambodia) and developed countries (the USA and Singapore). Self-efficacy was the only variable significantly related to behavioral intention in the developing countries. In contrast, perceived threat, expected benefits, and media attention were significant predictors in the developed countries. Trust in information sources also had a consistent impact across the two samples. Theoretical and practical implications of the findings are discussed.
Review of simulations of climate variability and change with the GFDL R30 coupled climate model

A review is presented of the development and simulation characteristics of the most recent version of a global coupled model for climate variability and change studies at the Geophysical Fluid Dynamics Laboratory, as well as a review of the climate change experiments performed with the model. The atmospheric portion of the coupled model uses a spectral technique with rhomboidal 30 truncation, which corresponds to a transform grid with a resolution of approximately 3.75 longitude by 2.25 latitude. The ocean component has a resolution of approximately 1.875 longitude by 2.25 latitude. Relatively simple formulations of river routing, sea ice, and land surface processes are included. Two primary versions of the coupled model are described, differing in their initialization techniques and in the specification of sub-grid scale oceanic mixing of heat and salt. For each model a stable control integration of near millennial scale duration has been conducted, and the characteristics of both the time-mean and variability are described and compared to observations. A review is presented of a suite of climate change experiments conducted with these models using both idealized and realistic estimates of time-varying radiative forcing. Some experiments include estimates of forcing from past changes in volcanic aerosols and solar irradiance. The experiments performed are described, and some of the central findings are highlighted. In particular, the observed increase in global mean surface temperature is largely contained within the spread of simulated global mean temperatures from an ensemble of experiments using observationally-derived estimates of the changes in radiative forcing from increasing greenhouse gases and sulfate aerosols.
An Examination of Social Validity Within Single-Case Research With Students With Emotional and Behavioral Disorders

In this article, we reviewed social validity in single-case research studies that focused on interventions for students who have either been identified as having, or as at-risk for emotional and behavioral disorders. This review focused on studies from four peer-reviewed journals known to publish single-case research with this population: the Journal of Applied Behavior Analysis, Journal of Emotional and Behavioral Disorders, Journal of Positive Behavior Interventions, and Behavioral Disorders. We reviewed 22 studies published from January 2008 to November 2011 that met inclusion criteria. The purposes of this review were (a) to evaluate how researchers are addressing social validity as defined by Horner and colleagues (2005) and (b) to explore how single-case researchers are measuring social validity. Overall, results indicated that the research studies included in this review addressed socially important questions within typical contexts, but that most did not address social validity explicitly.
Commentary on Beutler et al.'s "Common, Specific, and Treatment Fit Variables in Psychotherapy Outcome"

The “gap” between science and practice is a longstanding and unresolved issue in clinical psychology and related disciplines, which has been articulated by a number of writers from a range of therapy orientations from both sides of the divide (Beutler, Williams, Wakefield, & Entwistle, 1995; Goldfried & Wolfe, 1996). In discussing this issue, Masling (1996) noted that one way to bridge this gap would be to carry out more interesting and informative research. Larry Beutler and colleagues (this issue, pp 255–281) are to be congratulated for doing just that. They provide a great service to the psychological and psychotherapy community by tackling particularly vexing issues that have long consumed the field’s attention and doing so with a creative and interesting approach that is satisfying to both sides of science–practice divide. Using a large data set that combines data from five studies examining seven treatments, Beutler and colleagues examine the relative contribution of both common (e.g., the therapeutic alliance) and specific factors (e.g., therapist directiveness) that have been shown to be related to positive treatment outcomes. They also examined patient characteristics and most creatively the fit or match between patient factors and treatment factors and their impact on
BCG-Induced Dendritic Cell Responses and Suppression of Interleukin-5 Production from T Cells in Atopic Asthmatics

Bacille Calmette-Guérin (BCG) induces potent Th1 responses with the help of interleukin (IL)-10 and IL-12 released from dendritic cells (DCs), and suppresses Th2-associated allergic reactions. However, there are still some controversies on therapeutic effects of BCG in asthmatics. This study investigated whether BCG administration to DCs suppresses IL-5 production from T cells in atopic asthmatics. DCs derived from peripheral blood of subjects were cultured with or without BCG and Dermatophagoides farinae extract. Some DCs were co-cultured with T cells in the presence of BCG or the above culture supernatants. In the atopic asthmatics, BCG significantly increased IL-10 and IL-12 production from DCs. In the presence of D. farinae extract, BCG further increased IL-10 production. BCG-induced IL-10 production was significantly higher in the atopics (n=14) than in the non-atopics (n=9). Both BCG and the BCG-treated DCs culture supernatant significantly increased IFN-γ production from T cells. Both BCG and the supernatant from DCs+BCG+D. farinae co-cultures significantly decreased IL-5 production (all p<0.05), but the supernatant from DCs+BCG co-cultures did not. In conclusion, administration of BCG together with D. farinae extract effectively decreased IL-5 production from T cells, probably through the action of IL-10 and IL-12 released from DCs in D. farinae-sensitive asthmatics.
Durkheim and Criminology: Reconstructing the Legacy

Abstract The article offers an overview of Emile Durkheim's substantial and surprisingly diverse legacy for criminology. This is shown to run the gamut from positivism through to social constructivism. Further, it includes insights into deviance, social control and the law. Although broad in scope and often brilliant, his contribution is perhaps insufficiently acknowledged. Reasons for this oversight are given, as are some indications of future directions for Durkheimian criminology.
Expression of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Metalloproteinase-1 and -2 in Intraductal and Nonintraductal Growth Type of Cholangiocarcinoma

BACKGROUND:The intraductal growth (IG) type of cholangiocarcinoma has a better prognosis than the mass forming (MF) and periductal infiltrating (PI) types. Matrix metalloproteinase (MMP)-2 and MMP-9, regulated by tissue inhibitor of metalloproteinases (TIMP)-2 and TIMP-1, respectively, play important roles in the degradation of the basement membrane during tumor invasion. Alteration in MMPs and TIMPs may regulate the gross morphology of cholangiocarcinoma.METHODS:MMP-2 and MMP-9 were analyzed in 35 cholangiocarcinomas and 4 normal livers with fresh tissue using zymography and real-time reverse transcription-polymerase chain reaction (RT-PCR), and expressions of MMP-2, MMP-9, TIMP-1, and TIMP-2 were evaluated in 76 cholangiocarcinomas by immunohistochemistry.RESULTS:Activity of MMP-2 and its active form were detected in 80% and 57% of cholangiocarcinomas respectively. The total MMP-2, active 62 kDa MMP-2, and MMP-2 mRNA increased 5.4 and 8.2 times, 4.4 and 10.9 times, and 2.9 and 5.8 times in the MF and PI types, respectively, compared to the IG type. The majority of MMP-9 was in the proform and active 82 kDa MMP-9 was detected in 9% of cholangiocarcinomas. MMP-9 revealed no significant difference in relation to the gross types. The balanced expressions of MMP-2/TIMP-2 and MMP-9/TIMP-1 were significantly decreased in the MF and PI types, compared to the IG type. In the normal and nonneoplastic livers, the expressions of MMP-2 and MMP-9 were very low without active forms.CONCLUSIONS:The activities of MMP-2 and loss of balanced expressions of MMP-2/TIMP-2 and MMP-9/TIMP-1 are suggested as playing important roles in invasive growth related to the gross type of cholangiocarcinoma.
Evaluation of Dietary Multiple Enzyme Preparation (Natuzyme) in Laying Hens

The current experiment was designed to evaluate the efficacy of adding the multi-enzyme mixture (Natuzyme) into layers’ diets with different levels of energy and available phosphorus in relation to laying performance, egg qualities, blood cholesterol level, microflora and intestinal viscosity. Two hundred and fifty 43-wk-old Hy-Line commercial layers were divided into five groups with five replicates per group (10 birds per replicate) and fed one of five experimental diets. A corn and soybean meal-based control diet was formulated and used as a control diet. Two experimental control diets were formulated to reduce energy and crude protein contents (rE) or energy, crude protein and phosphorus contents (rEP). In addition, Natuzyme was added into either rE (rE-Natu500) or rEP (rEP-Natu500) diet to reach a concentration of 500 mg per kg of diet. The experiment lasted 8 weeks. There were no significant differences in feed intake, egg production, egg weight, egg qualities such as eggshell color or Haugh unit, total cholesterol, relative organ weights and cecal microflora profiles between any dietary treatments. Natu500 supplementation into the rE diet, but not rEP diet significantly increased egg mass and eggshell qualities such as strength and thickness, but it decreased cecal ammonia concentration and intestinal viscosity in laying hens. In conclusion, the present study shows that adding multiple enzyme preparation could improve performance of laying hens fed energy and protein restricted diets.