Miracle-dz/UniFAR-FTUs huggingface dataset:
Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults.

BACKGROUND Selenium, an essential trace element involved in defense against oxidative stress, may prevent cancer and cardiovascular disease. We evaluated the association between selenium levels and all-cause and cause-specific mortality in a representative sample of US adults. METHODS Serum selenium levels were measured in 13,887 adult participants in the Third National Health and Nutrition Examination Survey. Study participants were recruited from 1988 to 1994 and followed up for mortality for up to 12 years. RESULTS The mean serum selenium level was 125.6 ng/mL. The multivariate adjusted hazard ratios comparing the highest (> or = 130.39 ng/mL) with the lowest (< 117.31 ng/mL) serum selenium level tertile were 0.83 (95% confidence interval [CI], 0.72-0.96) for all-cause mortality, 0.69 (95% CI, 0.53-0.90) for cancer mortality, and 0.94 (95% CI, 0.77-1.16) for cardiovascular mortality. However, based on spline regression models, the association between serum selenium levels and all-cause and cancer mortality was nonlinear, with an inverse association at low selenium levels (< 130 ng/mL) and a modest increase in mortality at high selenium levels (> 150 ng/mL). There was no association between serum selenium levels and cardiovascular mortality. CONCLUSIONS In a representative sample of the US population, we found a nonlinear association between serum selenium levels and all-cause and cancer mortality. Increasing serum selenium levels were associated with decreased mortality up to 130 ng/mL. Our study, however, raises the concern that higher serum selenium levels may be associated with increased mortality.
Incidental detection of sinus mucosal abnormalities on CT and MRI imaging of the head.

PURPOSE To investigate the prevalence of incidental sinus abnormalities on CT and MRI imaging of the head, and identify if there is any correlation between patient symptomatology and image findings. MATERIALS AND METHODS One hundred and fifteen patients who underwent head CT or MRI for non-sinus related indications were included in this study, with image findings being analysed based on the Lund-Mackay Grading System (LMS). These were compared with their symptomatology based on the SNAQ-11 questionnaire. Two reviewers who were blinded to the patients' SNAQ-11 scores analysed the images. Patients were also referred to an ENT surgeon for anterior rhinoscopy in an attempt to seek a correlation between symptomatology and/or imaging findings against clinical assessment. RESULTS The prevalence of incidental sinus abnormalities is between 14.8% and 37% for CT and 29.5% and 85.2% for MRI, depending upon the cutoff LMS used. There was no significant difference in the incidence rate between the different age groups or genders. Asymptomatic patients had a significantly lower incidence rate of sinus mucosal abnormalities (8.2-57.1%) when compared to the symptomatic patients (33.3-66.7%) (P<0.01). A significant correlation was found between the MRI sinus findings and patients' symptoms (r=0.59, P<0.001) with no correlation demonstrated in the CT group. The mean LM score for the patients with clinical sinusitis was 6.2, while the normal patients had a mean LM score of 2.2. CONCLUSIONS MRI is more sensitive than CT to detect sinus mucosal abnormalities. A significant correlation is noticed between MRI findings and patients' symptomatology.
LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation

Leucine-rich-alpha-2-glycoprotein 1 (LRG1) has been shown to be involved in various human malignancies. Whether it plays a role in colorectal cancer (CRC) development remains unclear. Here, we investigated whether and through what mechanism LRG1 functions in human CRC cells. The plasma level of LRG1 was significantly increased in CRC patients, but it was remarkably decreased in patients with resected colorectal cancers. Meanwhile, both mRNA and protein levels of LRG1 were remarkable overexpressed in CRC tissues than normal tissues. The knockdown of LRG1 significantly inhibited cell proliferation, induced cell cycle arrest at the G0/G1 phase, and promoted apoptosis in SW480 and HCT116 cells in vitro. In addition, LRG1 silencing led to the downregulation of the levels of key cell cycle factors, such as cyclin D1, B, and E and anti-apoptotic B-cell lymphoma-2(Bcl-2). However, it up-regulated the expression of pro-apoptotic Bax and cleaved caspase-3. Furthermore, RUNX1 could be induced by LRG1 in a concentration-dependent manner, while the knockdown of RUNX1 blocked the promotion of the proliferation and inhibition of apoptosis induced by LRG1. Collectively, these findings indicate that LRG1 plays a crucial role in the proliferation and apoptosis of CRC by regulating RUNX1 expression. Thus, LRG1 may be a potential detection biomarker as well as a marker for monitoring recurrence and therapeutic target for CRC.
Development and Validation of a Vitamin D Status Prediction Model in Danish Pregnant Women: A Study of the Danish National Birth Cohort

Vitamin D has been hypothesized to reduce risk of pregnancy complications such as preeclampsia, gestational diabetes mellitus, and preterm delivery. However, many of these outcomes are rare and require a large sample size to study, representing a challenge for cohorts with a limited number of preserved samples. The aims of this study were to (1) identify predictors of serum 25-hydroxy-vitamin D (25(OH)D) among pregnant women in a subsample (N = 1494) of the Danish National Birth Cohort (DNBC) and (2) develop and validate a score predicting 25(OH)D-status in order to explore associations between vitamin D and maternal and offspring health outcomes in the DNBC. In our study sample, 42.3% of the population had deficient levels of vitamin D (<50 nmol/L 25(OH)D) and average levels of 25(OH)D-status were 56.7(s.d. 24.6) nmol/L. A prediction model consisting of intake of vitamin D from diet and supplements, outdoor physical activity, tanning bed use, smoking, and month of blood draw explained 40.1% of the variance in 25(OH)D and mean measured 25(OH)D-level increased linearly by decile of predicted 25(OH)D-score. In total 32.2% of the women were placed in the same quintile by both measured and predicted 25(OH)D-values and 69.9% were placed in the same or adjacent quintile by both methods. Cohen's weighted kappa coefficient (Κ = 0.3) reflected fair agreement between measured 25(OH)D-levels and predicted 25(OH)D-score. These results are comparable to other settings in which vitamin D scores have shown similar associations with disease outcomes as measured 25(OH)D-levels. Our findings suggest that predicted 25(OH)D-scores may be a useful alternative to measured 25(OH)D for examining associations between vitamin D and disease outcomes in the DNBC cohort, but cannot substitute for measured 25(OH)D-levels for estimates of prevalence.
The Research on Multi-task Bundling of Public-Private Partnerships Based on Principal-Agent Model

Under the Financial Crisis, it is important for China to make use of Public-Private Partnerships (PPP) for infrastructure construction. This paper emphasizes multi-task bundling of PPP on the condition of incomplete contracts and asymmetric information, involving the bundling of two tasks of building and operating infrastructures used for the provision of public services, as well as that of three tasks of building, operating and financing infrastructures. It presents a basic model to analyze whether the bundling of different tasks is better than traditional unbundling. It is concluded that, in the incomplete contracts considering the efforts in quality improvement and cost reduction, bundling of the two tasks always strictly dominates unbundling no matter what sign of externality across construction and operation is. It is also concluded that, with the government freely choosing the user charge, bundling of three tasks of building, operating and financing dominates unbundling (that is to say, only bundling two tasks of building and operating).
The two sides of the tactics of influence: agent vs. target

The study reported here focused on both the target and the agent of influence, and examined the differences in their perceptions of the reasons for and the tactics of influence. Following attribution theory, it was hypothesized that agents would give more reasons than targets signifying power over the targets' behaviour and exercise strong tactics to influence their targets. On the other hand, targets would minimize the strong tactics being exercised upon them and emphasize reasons signifying their self-control and agents' dependence on their help. The differences between agents and targets were expected to be more significant for bosses as agents and subordinates as targets than for any other status-perspective combination. A total of 206 middle-level managers participated in the study; 125 of them responded as agents and 81 responded as targets. Kipnis et al.'s (1980) questionnaire, consisting of five reasons for influencing others and 58 tactics of influence, was used. Nine dimensions of influence were found by factor analyses. Results clearly supported the research hypotheses.
Delivery of Prolamins to the Protein Storage Vacuole in Maize Aleurone Cells[W]

This study uses a combination of molecular approaches, in vivo imaging of fluorescent proteins, and structural analysis by electron tomography to study the synthesis and transport of storage proteins in aleurone cells. It describes an unusual autophagic mechanism for the delivery of storage proteins to the vacuole that may be common to cereals. Zeins, the prolamin storage proteins found in maize (Zea mays), accumulate in accretions called protein bodies inside the endoplasmic reticulum (ER) of starchy endosperm cells. We found that genes encoding zeins, α-globulin, and legumin-1 are transcribed not only in the starchy endosperm but also in aleurone cells. Unlike the starchy endosperm, aleurone cells accumulate these storage proteins inside protein storage vacuoles (PSVs) instead of the ER. Aleurone PSVs contain zein-rich protein inclusions, a matrix, and a large system of intravacuolar membranes. After being assembled in the ER, zeins are delivered to the aleurone PSVs in atypical prevacuolar compartments that seem to arise at least partially by autophagy and consist of multilayered membranes and engulfed cytoplasmic material. The zein-containing prevacuolar compartments are neither surrounded by a double membrane nor decorated by AUTOPHAGY RELATED8 protein, suggesting that they are not typical autophagosomes. The PSV matrix contains glycoproteins that are trafficked through a Golgi-multivesicular body (MVB) pathway. MVBs likely fuse with the multilayered, autophagic compartments before merging with the PSV. The presence of similar PSVs also containing prolamins and large systems of intravacuolar membranes in wheat (Triticum aestivum) and barley (Hordeum vulgare) starchy endosperm suggests that this trafficking mechanism may be common among cereals.
Autoimmune Pancreatitis: Possibilities of CT Characterization

Background: Pancreatitis is defined as an inflammatory disease of the pancreas, leading to morphological and pathological changes. Recently, an autoimmune pathogenesis of this disease has been proposed. This type of pancreatitis should be differentiated from other pancreatic diseases, since appropriate therapy is effective and morphological changes and pancreatic function can recover to normal levels. Aim of the Study: To assess the possibility of distinguishing autoimmune pancreatitis from other pancreatic diseases with an analogous clinical presentation on the basis of CT findings alone. Methods: The CT images of 7 patients with proven autoimmune pancreatitis, along with those of 20 patients with other pancreatic diseases, but with an analogous clinical presentation, were retrospectively evaluated in a blinded fashion by 2 radiologists. In particular, the radiologists had to search for the typical signs of autoimmune pancreatitis. Discordant cases were further analyzed in the presence of a 3rd radiologist. The final diagnosis was acquired by means of a majority or overall consensus. The sensitivity, specificity, positive and negative predictive values of CT were calculated against each of the diseases (autoimmune pancreatitis; other pancreatic diseases), in order to evaluate the diagnostic value of the scan. Results: After the consensus evaluation, the correct diagnosis was reached in 25/27 (92.5%) cases, with only 2/27 wrong diagnoses (autoimmune pancreatitis diagnosed as another pancreatic disease and vice versa). The sensitivity and specificity of CT against autoimmune pancreatitis were 86 and 95%, respectively. The positive and negative predictive values were 89 and 93%, respectively. Conclusion: Patients with autoimmune pancreatitis demonstrate imaging findings that enable the correct diagnosis by dynamic CT, even in the presence of nonspecific clinical symptoms. The precise classification of the disease is extremely important, since simple steroid therapy then represents the correct treatment, and leads to complete recovery.
People with intellectual disability as neighbours: Towards understanding the mundane aspects of social integration

Although people with intellectual disabilities (ID) are increasingly expected to relocate from traditional institutional care to ‘regular’ neighbourhood housing facilities and socially integrate in these neighbourhoods, little is known about how they are perceived and appreciated as neighbours. This paper reports on interviews carried out with 30 neighbours without ID who were neighbours of small-scale care facilities for people with ID. Interviews addressed the neighbours' everyday experiences of neighbouring in general, and neighbouring people with ID in particular. Neighbouring, for these informants, called for a fine balance between friendliness without over-involvement. While they were generally positive about their interactions with their neighbours with ID, it emerged that the formal nature of the care facility and the interaction style of some of the neighbours with ID often contravened informants' assumptions about neighbouring. Informants expressed concern about a possible lack of appropriate distance, reciprocity and accountability among their neighbours with ID. The nature of the care facility, with paid staff, often group activities, formal means of achieving the everyday small tasks which neighbours sometimes do for each other, and a high turnover of residents, all undermined the possibility of a typical neighbourly relationship. In conclusion, we suggest that integration of people with ID into everyday neighbouring relationships raises complex challenges for care organizations that need to find a balance between supporting the needs of people with ID they care for, adequate support and mediation for other neighbours when necessary, and all the while avoid becoming overly involved in neighbouring as a formal partner. Copyright © 2010 John Wiley & Sons, Ltd.
Walking out of two-level social traps (with a little help from my friends)

Studies of iterated prisoner's dilemmas (IPD) have shown that agents can escape the social trap of mutual defection by focusing on future gains or by learning from prior experiences. This terrain has been well charted. Yet only recently has attention turned to how groups of agents engage in an IPD scenario against other groups, a scenario that the author dubs “two-level social traps. ” This article investigates the impact of group size on the performance of groups in a two-group IPD based on Michael W. Macy's STOCHASTIC LEARNING MODEL OF SOCIAL EXCHANGE. The findings of the study suggest that when a democratic (majoritarian) decision rule is used, larger groups perform better in moving from an uncooperative equilibrium to a cooperative equilibrium. The proposed explanation for this is that larger groups reduce uncertainty in the random processes of strategy selection.
Laughing at Absence: Instinct Magazine and the Hyper-Masculine Gay Future?

Instinct is a nationally distributed gay male magazine that relies on the strategies of humor and irony, encouraging their readers to not take life too seriously. Mirroring the sarcasm of popular straight men's magazines from the 1990s, such as Maxim, Instinct casts its audience in the role of the hyper-masculine queer, reifying masculine control of female sexuality, while constructing the fantasy of sexual domination over straight men and “older” gay men. This article provides an ideological analysis of Instinct, focusing on the themes of gay aging, representations of “young” and “old,” the sexualizing of older gay men, and the absent discussion of future to further understand how the concepts of age, aging, and the future are constructed in gay popular discourse. While defending itself through the justification of “harmless fun” and mocking its critics as “sad losers” who are not in an the joke, Instinct reinscribes ideologies of youthism, myths of gay male aging, and leaves the future as a question to be avoided.
The Copper Transporter RAN1 Is Essential for Biogenesis of Ethylene Receptors in Arabidopsis*

Plants utilize ethylene as a hormone to regulate multiple developmental processes and to coordinate responses to biotic and abiotic stress. In Arabidopsis thaliana, a small family of five receptor proteins typified by ETR1 mediates ethylene perception. Our previous work suggested that copper ions likely play a role in ethylene binding. An independent study indicated that the ran1 mutants, which display ethylene-like responses to the ethylene antagonist trans-cyclooctene, have mutations in the RAN1 copper-transporting P-type ATPase, once again linking copper ions to the ethylene-response pathway. The results presented herein indicate that genetically engineered Saccharomyces cerevisiae expressing ETR1 but lacking the RAN1 homolog Ccc2p (Δccc2) lacks ethylene-binding activity. Ethylene-binding activity was restored when copper ions were added to the Δccc2 mutants, showing that it is the delivery of copper that is important. Additionally, transformation of the Δccc2 mutant yeast with RAN1 rescued ethylene-binding activity. Analysis of plants carrying loss-of-function mutations in ran1 showed that they lacked ethylene-binding activity, whereas seedlings carrying weak alleles of ran1 had normal ethylene-binding activity but were hypersensitive to copper-chelating agents. Altogether, the results show an essential role for RAN1 in the biogenesis of the ethylene receptors and copper homeostasis in Arabidopsis seedlings. Furthermore, the results indicate cross-talk between the ethylene-response pathway and copper homeostasis in Arabidopsis seedling development.
Market Making with Asymmetric Information and Inventory Risk

Market makers in some financial markets often make offsetting trades and have significant market power. We develop a market making model that captures these market features as well as other important characteristics such as information asymmetry and inventory risk. In contrast to the existing literature, a market maker in our model can optimally shift some trades with some investors to other investors by adjusting bid or ask. As a result, we find that consistent with empirical evidence, expected bid–ask spreads may decrease with information asymmetry and bid–ask spreads can be positively correlated with trading volume.
The Corporatization of Research in Australian Higher Education

The recent public policy trend emphasising markets and economic logic among public sector institutions, including universities, has led to the introduction of greater managerialism and formal demonstrations of efficiency and effectiveness. Such moves require a definition of inputs, outputs and outcomes as a means to renderingthese activities visible and measurable.In Australian universities, recent changes to higher education policy (particularly research and science policy) have tightened control by Federal Government over academic professional activities and increased the drive to render professional activities calculable (simple, standardized) for the allocation of scarce resources.This paper focuses on the narrowing of definitions in two particular areas, namely, research publication and the funding of postgraduate research degree completions. The paper argues that such policy strategies reinforce selectivity of styles of research, types of research problems undertaken, and favour the research approaches of some disciplines over others (that is, "big" science over "small" science and science over humanities and social science). A further consequence is tighter central control over both higher education institutions and academic professionals. Academics experience a drive to define their activity as either teaching or research, as opposed to teaching and research. This policy drive leads to a narrowing of professional activity into discreet categories. A further consequence of this drive on the part of the Federal Government may be the definition of higher education institutions into one of three categories, as either "teaching" or "research" universities, with a third group predominately "teaching" but undertaking some "research". As with other performance-based funding mechanisms, this may lead to a significant re-allocation of resources and standing amongst Universities in Australia.
Non-anthropocentric Reasoning in Children: Its incidence when they are confronted with ecological dilemmas

This study used an individual structured interview to (1) verify the incidence of non-anthropocentric reasoning in 123 children attending the 3rd and 4th years in three primary schools in the Lisbon area (Portugal), when they are confronted with ecological dilemmas and (2) establish those places they frequented which permit animal contact. The results show a greater incidence of non-anthropocentric reasoning than that obtained in other international studies. This may be related to the focus of the questions asked, which invited children to imagine themselves as another animal or to present situations where human interaction is unfair. This incidence was found independently of gender, school origin and whether or not pets were owned, even with the more biologically complex animals. School year was the only variable proven to make a difference in conceptually more demanding questions. We also verified that the children's general past experience of nature is essentially aligned to ‘controlled environments depending on ongoing human management’, confirming a decline in direct contact with ‘natural and semi-natural environments’. However, this type of experience does not seem to exert a negative influence on their non-anthropocentric reasoning.