Miracle-dz/UniFAR-FTUs huggingface dataset:
RP-HPLC Estimation of Ramipril and Telmisartan in Tablets

A rapid high performance liquid chromatographic method has been developed and validated for the estimation of ramipril and telmisartan simultaneously in combined dosage form. A Genesis C18 column having dimensions of 4.6×250 mm and particle size of 5 μm in isocratic mode, with mobile phase containing a mixture of 0.01 M potassium dihydrogen phosphate buffer (adjusted to pH 3.4 using orthophosphoric acid): methanol:acetonitrile (15:15:70 v/v/v) was used. The mobile phase was pumped at a flow rate of 1.0 ml/min and the eluents were monitored at 210 nm. The selected chromatographic conditions were found to effectively separate ramipril (Rt: 3.68 min) and telmisartan (Rt: 4.98 min) having a resolution of 3.84. The method was validated in terms of linearity, accuracy, precision, specificity, limit of detection and limit of quantitation. Linearity for ramipril and telmisartan were found in the range of 3.5-6.5 μg/ml and 28.0-52.0 μg/ml, respectively. The percentage recoveries for ramipril and telmisartan ranged from 99.09-101.64% and 99.45-100.99%, respectively. The limit of detection and the limit of quantitation for ramipril was found to be 0.5 μg/ml and 1.5 μg/ml respectively and for telmisartan was found to be 1.5 μg/ml and 3.0 μg/ml, respectively. The method was found to be robust and can be successfully used to determine the drug content of marketed formulations.
Uptake of Cadmium by Hydroponically Grown, Mature Eucalyptus Camaldulensis Saplings and the Effect of Organic Ligands

The potential suitability of Eucalyptus camaldulensis for Cd phytoextraction was tested in a hydroponic study. Saplings were exposed to 4.5 and 89 μM Cd for one month, with and without EDTA and s,s-EDDS at 0.1, 1, and 5 mM. The saplings’ growth was not affected at the 4.5 μM Cd concentration, yet it decreased 3-fold at 89 μM, and almost all the Cd taken up was immobilized in the roots, reaching 360 and 5300 mg Cd kg−1, respectively (approximately 75% of which was non-washable in acid). The respective Cd root-to-shoot translocation factors were 0.14 and ≈5*10−4. At 0.1 mM concentration, EDTA and EDDS had no effect or even a positive effect on the saplings growth. This was reversed at 1 mM, and the chelants became lethal at the 5 mM concentration. At 89 μM Cd in the growth medium, 0.1 mM EDTA increased Cd translocation into the shoots by almost 10-fold, however it strongly reduced Cd content inside the roots. This hydroponic study indicates the feasibility of E. camaldulensis use for cleanup Cd-contaminated soils at environmental concentrations, both for site stabilization (phytostabilization) and gradual remediation (phytoextraction). EDTA was shown to be much more efficient in enhancing Cd translocation than s,s-EDDS.
A triple layer location management strategy for wireless cellular networks

Location areas is a popular location management scheme in cellular networks. In the location areas scheme, a mobile terminal updates its location whenever it moves into a cell that belongs to a new location area. However, no matter how the location areas are designed, the location update ping-pong effect exists when a mobile terminal moves back and forth between two location areas. The paper defines a new kind of ping-pong effect, referred to as the generalized ping-pong effect, and shows that it accounts for a non-negligible portion of the total location update cost. Although several strategies have been proposed to reduce the ping-pong effect in the literature, they either fail to eliminate the generalized ping-pong effect or introduce a larger paging cost. The paper proposes a triple-layer location management strategy to eliminate the generalized ping-pong effect, therefore greatly reducing the total location update cost. Simulation results show that the triple-layer strategy outperforms the existing schemes designed to reduce the ping-pong effect.
Resolvent of large random graphs

We analyze the convergence of the spectrum of large random graphs to the spectrum of a limit infinite graph. We apply these results to graphs converging locally to trees and derive a new formula for the Stieltjes transform of the spectral measure of such graphs. We illustrate our results on the uniform regular graphs, Erdös‐Rényi graphs and graphs with a given degree sequence. We give examples of application for weighted graphs, bipartite graphs and the uniform spanning tree of n vertices. © 2010 Wiley Periodicals, Inc. Random Struct. Alg. , 2010
Genetic and phenotypic parameter estimates of birth weight in Holstein Friesian calves

In the present research estimation genetic and phenotypic parameters associated with birth weight in Holstein Friesian calves were done. The data of the present research consisted of calving records from 1986 to 1991 of Holstein Friesian raised at the Polatl ı Agriculture Farm. The effects of environmental macro-factors such as birth season, year and sex of calves on the birth weight were investigated. According to the result, the least squares of birth weight were 36.79 ± 0.068 kg. The effects of calving season, year and sex on the birth weight were found to be statistically significant (P < 0.01). Repeatability and heritability estimates for birth weight were 0.07 ± 0.041 and 0.29 ± 0.03.
Unsupervised dictionary learning with double-layer sparse representation

This paper presents a novel double-layer sparse representation (DLSR) approach for unsupervised dictionary learning. In supervised/unsupervised discriminative dictionary learning, classical approaches usually develop a discriminative term for learning multiple sub-dictionaries, each of which corresponds to one-class training image patches. However, in unsupervised scenario, some of the training patches for learning sub-dictionaries of each class are related to more than one class. Thus, we propose a DLSR formulation, in this paper, to impose the first-layer sparsity on the coefficients and the second-layer sparsity on the classes for each training patch, embedding both the reconstructive (via the first-layer) and discriminative (via the second-layer) abilities in the dictionary. To address the proposed DLSR formulation, a simple yet effective algorithm, called DLSR-OMP, is developed in light of the conventional OMP. Finally, the experimental results show the effectiveness of our approach in the reconstruction task of image denoising and the clustering task of texture segmentation.
Immunohistochemical characteristics of polymyositis in patients with HTLV‐1–associated myelopathy and HTLV‐I carriers

The immunohistochemical characteristics of polymyositis in patients with HTLV‐I‐associated myelopathy (HAM) and HTLV‐I carriers were studied. Infiltrating cells were predominantly T cells and were not different from in the control group. All specimens contained positively staining muscle fibers for MHC class I antigens, but class II antigens were also expressed in some muscle fibers in 1 patient with HTLV‐I‐negative polymyositis, 3 patients with HTLV‐I‐positive polymyositis, and all 5 HAM patients with polymyositis. Expression of the neural cell adhesion molecule was lowest in the HAM patients. These findings may suggest a different immune environment in polymyositis with HAM. © 1993 John Wiley & Soncs, Inc.
Auxin Activates the Plasma Membrane H+-ATPase by Phosphorylation during Hypocotyl Elongation in Arabidopsis1[W][OA]

The phytohormone auxin is a major regulator of diverse aspects of plant growth and development. The ubiquitin-ligase complex SCFTIR1/AFB (for Skp1-Cul1-F-box protein), which includes the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX (TIR1/AFB) auxin receptor family, has recently been demonstrated to be critical for auxin-mediated transcriptional regulation. Early-phase auxin-induced hypocotyl elongation, on the other hand, has long been explained by the acid-growth theory, for which proton extrusion by the plasma membrane H+-ATPase is a functional prerequisite. However, the mechanism by which auxin mediates H+-ATPase activation has yet to be elucidated. Here, we present direct evidence for H+-ATPase activation in etiolated hypocotyls of Arabidopsis (Arabidopsis thaliana) by auxin through phosphorylation of the penultimate threonine during early-phase hypocotyl elongation. Application of the natural auxin indole-3-acetic acid (IAA) to endogenous auxin-depleted hypocotyl sections induced phosphorylation of the penultimate threonine of the H+-ATPase and increased H+-ATPase activity without altering the amount of the enzyme. Changes in both the phosphorylation level of H+-ATPase and IAA-induced elongation were similarly concentration dependent. Furthermore, IAA-induced H+-ATPase phosphorylation occurred in a tir1-1 afb2-3 double mutant, which is severely defective in auxin-mediated transcriptional regulation. In addition, α-(phenylethyl-2-one)-IAA, the auxin antagonist specific for the nuclear auxin receptor TIR1/AFBs, had no effect on IAA-induced H+-ATPase phosphorylation. These results suggest that the TIR1/AFB auxin receptor family is not involved in auxin-induced H+-ATPase phosphorylation. Our results define the activation mechanism of H+-ATPase by auxin during early-phase hypocotyl elongation; this is the long-sought-after mechanism that is central to the acid-growth theory.
Preprocessing of 18F-DMFP-PET Data Based on Hidden Markov Random Fields and the Gaussian Distribution

18F-DMFP-PET is an emerging neuroimaging modality used to diagnose Parkinson's disease (PD) that allows us to examine postsynaptic dopamine D2/3 receptors. Like other neuroimaging modalities used for PD diagnosis, most of the total intensity of 18F-DMFP-PET images is concentrated in the striatum. However, other regions can also be useful for diagnostic purposes. An appropriate delimitation of the regions of interest contained in 18F-DMFP-PET data is crucial to improve the automatic diagnosis of PD. In this manuscript we propose a novel methodology to preprocess 18F-DMFP-PET data that improves the accuracy of computer aided diagnosis systems for PD. First, the data were segmented using an algorithm based on Hidden Markov Random Field. As a result, each neuroimage was divided into 4 maps according to the intensity and the neighborhood of the voxels. The maps were then individually normalized so that the shape of their histograms could be modeled by a Gaussian distribution with equal parameters for all the neuroimages. This approach was evaluated using a dataset with neuroimaging data from 87 parkinsonian patients. After these preprocessing steps, a Support Vector Machine classifier was used to separate idiopathic and non-idiopathic PD. Data preprocessed by the proposed method provided higher accuracy results than the ones preprocessed with previous approaches.
Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy

Background—Pluripotent mesenchymal stem cells (MSCs) differentiate into a variety of cells, including cardiomyocytes and vascular endothelial cells. However, little information is available about the therapeutic potency of MSC transplantation in cases of dilated cardiomyopathy (DCM), an important cause of heart failure. Methods and Results—We investigated whether transplanted MSCs induce myogenesis and angiogenesis and improve cardiac function in a rat model of DCM. MSCs were isolated from bone marrow aspirates of isogenic adult rats and expanded ex vivo. Cultured MSCs secreted large amounts of the angiogenic, antiapoptotic, and mitogenic factors vascular endothelial growth factor, hepatocyte growth factor, adrenomedullin, and insulin-like growth factor-1. Five weeks after immunization, MSCs or vehicle was injected into the myocardium. Some engrafted MSCs were positive for the cardiac markers desmin, cardiac troponin T, and connexin-43, whereas others formed vascular structures and were positive for von Willebrand factor or smooth muscle actin. Compared with vehicle injection, MSC transplantation significantly increased capillary density and decreased the collagen volume fraction in the myocardium, resulting in decreased left ventricular end-diastolic pressure (11±1 versus 16±1 mm Hg, P<0.05) and increased left ventricular maximum dP/dt (6767±323 versus 5138±280 mm Hg/s, P<0.05). Conclusions—MSC transplantation improved cardiac function in a rat model of DCM, possibly through induction of myogenesis and angiogenesis, as well as by inhibition of myocardial fibrosis. The beneficial effects of MSCs might be mediated not only by their differentiation into cardiomyocytes and vascular cells but also by their ability to supply large amounts of angiogenic, antiapoptotic, and mitogenic factors.
RECENT DEVELOPMENTS IN VISION, AGING, AND DRIVING: 1988-1994

p p p p p-p p p p-p-~-This report provides a comprehensive review of recent research on age-related changes in vision and visual perception as they relate to concomitant age-related changes in driving behavior. Basic research as well as appliedmuman factors studies have been included in this review. The primary focus of the report is on work conducted since 1988-the year in which TRB Special Report 218 on improving the mobility and safety of older drivers was published. (203 references) 17.
The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus

Gestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. This study sought to determine the treatment effects of dietary supplementation with myo-inositol (MI) and vitamins B2, B6, B12, and D in a mouse model of GDM (pregnant db/+ dams). In addition, the individual effects of vitamin B2 were examined. Suboptimal B2 increased body weight and fat deposition, decreased GLUT4 adipose tissue expression, and increased expression of inflammatory markers. MI supplementation reduced weight and fat deposition, and reduced expression of inflammatory markers in adipose tissue of mice on suboptimal B2. MI also significantly reduced the hyperleptinemia observed in db/+ mice, when combined with supplemented B2. MI was generally associated with adipose tissue markers of improved insulin sensitivity and glucose uptake, while the combination of vitamins B2, B6, B12, and D was associated with a reduction in adipose inflammatory marker expression. These results suggest that supplementation with MI and vitamin B2 could be beneficial for the treatment/prevention of GDM.
Microarchitectures for Managing Chip Revenues under Process Variations

As transistor feature sizes continue to shrink intothe sub-90nm range and beyond, the effects of process variationson critical path delay and chip yields have amplified. A commonconcept to remedy the effects of variation is speed-binning, bywhich chips from a single batch are rated by a discrete range offrequencies and sold at different prices. In this paper, we discussstrategies to modify the number of chips in different bins andhence enhance the profits obtained from them. Particularly, wepropose a scheme that introduces a small Substitute Cacheassociated with each cache way to replicate the data elementsthat will be stored in the high latency lines. Assuming a fixedpricing model, this method increases the revenue by as much as13.8% without any impact on the performance of the chips.
Implications of the Fourth Industrial Age on Higher Education

Higher education in the fourth industrial revolution (HE 4.0) is a complex, dialectical and exciting opportunity which can potentially transform society for the better. The fourth industrial revolution is powered by artificial intelligence and it will transform the workplace from tasks based characteristics to the human centred characteristics. Because of the convergence of man and machine, it will reduce the subject distance between humanities and social science as well as science and technology. This will necessarily require much more interdisciplinary teaching, research and innovation. This paper explores the impact of HE 4.0 on the mission of a university which is teaching, research (including innovation) and service.
The Effects of Regionalization on Cost and Outcome for One General High‐Risk Surgical Procedure

PurposeThe effects of regionalization of tertiary care were studied by analyzing cost and outcome for pancreaticoduodenectomies in a state in which the majority of these high-risk procedures were performed in one hospital. MethodsUsing Maryland inpatient discharge data via a retrospective study, the authors compared cost and outcome data for a hospital with more than one half of the cases in the state to all other hospital providers as a group and with smaller groupings according to the volume of procedures performed. ResultsHospital mortality, length of stay, and costs were significantly less at the high-volume regional medical center when compared with all other hospitals. Mortality and cost increased as volume decreased when hospitals were grouped according to volume. ConclusionsAn academic medical center, functioning as a high-volume regional provider, can deliver tertiary care services with improved outcomes at lower costs than community hospitals.
DSM-5 diagnosis of Internet Gaming Disorder: Some ways forward in overcoming issues and concerns in the gaming studies field

Background and aims The current DSM-5 diagnosis of Internet Gaming Disorder (IGD; American Psychiatric Association [APA], 2013) has led to a number of issues and concerns that we highlighted in our recent paper (Kuss, Griffiths, & Pontes, 2017). Experts in the field responded to our evaluation of these issues resulting in six commentaries. Methods In this paper, we offer responses to the six commentaries to move the scientific field forward. All of the responses to our original paper highlighted many conceptual, theoretical, and/or methodological problems with the proposed IGD diagnosis as outlined in the DSM-5. We outline some ways forward in overcoming issues and concerns in the gaming studies field. Results We argue that rather than stigmatizing gaming per se, the role of scientists and practitioners is to establish a clear-cut distinction between someone who may use games excessively but non-problematically and someone who is experiencing significant impairment in their daily lives as a consequence of their excessive gaming. This responsibility needs to be shared by popular media who are often quick to build a moral panic around gaming behaviors, often based on cherry-picking specific case studies and pieces of research which support their headlines. Conclusion Researchers, practitioners, gaming developers, and the media need to work together and collaboratively to build a realistic and comprehensive understanding of gaming as a normal, enjoyable, and often beneficial sociocultural practice, which for a small minority of excessive users may be associated with the experience of addiction-related symptoms that may require professional support.
A novel bulk driven charge pump for low power, low voltage applications

In this article a novel charge pump circuit is introduced. The proposed circuit utilizes a bulk driven cascode current mirror through an adaptive gate bias technique, that results in a high output impedance over a very wide output voltage range, accurate Charge/ Discharge current matching, which minimizes the steady-state phase error in a phase-locked loop (PLL), and low transient glitches. The current variation is less than 0.5 μA or 1% over output range. Therefore proposed circuit stabilizes the loop bandwidth of the charge pump PLL and maximizes the dynamic range. The charge pump is designed and simulated under the power supply of 1.8 V in 0. 18μm CMOS technology to verify the efficiency of the proposed techniques. Monte Carlo process variations and mismatch simulations show that the current variation in the proposed charge pump is very low.
Meige syndrome and pallidal deep brain stimulation

The cause of primary Meige syndrome is unknown, and although gender and age predilections are different from idiopathic torsion dystonia, most investigators consider Meige syndrome a variant of that disorder. Interest in the use of stereotactic brain surgery for refractory forms of dystonia is thus increasing. There is little experience with the use of deep brain stimulation (DBS) in focal dystonias, and reports of its use in Meige syndrome are very rare. We report on a case of Meige syndrome successfully treated with bilateral pallidal DBS. © 2005 Movement Disorder Society
The activity‐induced reduction of myofibrillar Ca2+ sensitivity in mouse skeletal muscle is reversed by dithiothreitol

The aim of this study was to further characterize the reduction of myofibrillar Ca2+ sensitivity in mouse muscle which has been observed after fatigue at 37°C. Muscle bundles and single fibres were isolated from mouse flexor digitorum brevis muscle and studied at 37°C. The single fibres were injected with the Ca2+ indicator indo‐1. Muscle fatigue was produced by 0.4 s tetani repeated at 4 s intervals until force had fallen to less than 50% of initial. Excitation–contraction coupling was assessed by measuring the cytosolic calcium concentration ([Ca2+]i) during tetani, and the maximum Ca2+‐activated force and the myofibrillar Ca2+ sensitivity were estimated from a series of tetani at different stimulation frequencies. Two main results were found. (i) The reduction of Ca2+ sensitivity only occurred when the muscle was intensely stimulated leading to fatigue. When the muscle was rested for 10 min at 37°C there was no significant change in Ca2+ sensitivity. (ii) If the membrane‐permeant thiol‐specific reducing agent dithiothreitol (0.5 mm) was applied to the muscle for 2 min following the fatigue protocol, the reduction in Ca2+ sensitivity was reversed. Dithiothreitol had no effect on Ca2+ sensitivity in unfatigued preparations. There was no effect of fatigue or dithiothreitol on tetanic [Ca2+]i or on the maximum Ca2+‐activated force. These results suggest that intense activity of skeletal muscle at 37°C causes the production of reactive oxygen species which oxidize a target protein. We propose that critical sulphydryl groups on the target protein(s) are converted to disulphide bonds and this reaction reduces Ca2+ sensitivity.