Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality of Patient-Provider Communication Among Cancer Survivors: Findings From a Nationally Representative Sample

Purpose: Although patient-provider communication is an essential component of health care delivery, little is known about the quality of these discussions among patients with cancer. Methods: Data are from the 2011 Medical Expenditure Panel Survey Experiences with Cancer survey among 1,202 adult cancer survivors. We evaluated discussions with any provider after a cancer diagnosis about: (1) follow-up care; (2) late or long-term treatment effects; (3) lifestyle recommendations, such as diet, exercise, and quitting smoking; and (4) emotional or social needs. Using a response scale ranging from “did not discuss” to “discussed in detail,” a summary score was constructed to define communication quality as high, medium, or low. Patient factors associated with the quality of provider discussions were examined using multivariable polytomous logistic regression analyses. Results: At the time of the survey, approximately one half of the patients (46%) were either within 1 year (24.1%) or between 1 and 5 years (22.0%) of treatment. More than one third of cancer survivors reported that they did not receive detailed communication about follow-up care, and more than one half reported that they did not receive detailed communication regarding late or long-term effects, lifestyle recommendations, or emotional and social needs. Only 24% reported high-quality communication for all four elements, indicating that the vast majority experienced suboptimal communication. In multivariable analysis, survivors reporting a high communication quality with providers included those who were within 1 year of treatment, between the ages of 18 and 64 years, non-Hispanic black or other ethnicity, and married. Conclusion: Study findings demonstrate gaps in the communication quality experienced by cancer survivors in the United States and help identify survivors for targeted interventions.
Proportional Rankings

In this paper we extend the principle of proportional representation to rankings. We consider the setting where alternatives need to be ranked based on approval preferences. In this setting, proportional representation requires that cohesive groups of voters are represented proportionally in each initial segment of the ranking. Proportional rankings are desirable in situations where initial segments of different lengths may be relevant, e.g., hiring decisions (if it is unclear how many positions are to be filled), the presentation of competing proposals on a liquid democracy platform (if it is unclear how many proposals participants are taking into consideration), or recommender systems (if a ranking has to accommodate different user types). We study the proportional representation provided by several ranking methods and prove theoretical guarantees. Furthermore, we experimentally evaluate these methods and present preliminary evidence as to which methods are most suitable for producing proportional rankings.
The Effect of Asymmetric Information on Product Market Outcomes

We explore how asymmetric information in financial markets affects outcomes in product markets. Difference-in-difference tests around brokerage house merger/closure events (which increase asymmetric information through reductions in analyst coverage) indicate worse industry-adjusted sales growth for shocked firms than for their peers. Our results are consistent with Bolton and Scharfstein's (1990) tradeoff between investor agency concerns and predation risk. Further support is found in stronger treatment effects among firms with ex ante greater agency concerns, financing constraints, asymmetric information, and those operating in ex ante more competitive (fluid) product market spaces. Our results are concentrated in industries where we can clearly identify either net firm entry or exit.
The Effect of an Inhaled Corticosteroid on Glucose Control in Type 2 Diabetes

Objective: To determine the effect of inhaled corticosteroid (ICS) therapy on glucose control in adults with type 2 diabetes mellitus and coexisting asthma or chronic obstructive pulmonary disease (COPD). Design: A prospective randomized, double-blind, double-dummy placebo-controlled, crossover investigation of inhaled steroids and oral leukotriene blockers. Setting: A United States Department of Veterans Affairs Health Care System outpatient setting. Participants: Adults with type 2 diabetes and asthma or COPD. Methods: Subjects (n=12) were randomized to receive either inhaled fluticasone propionate (440 μg twice daily) and oral placebo, or inhaled placebo and oral montelukast (10 mg/day). After 6 weeks, subjects were switched to the opposite therapy for 6 weeks. The primary outcome measure was the change in the percentage of glycosylated hemoglobin (%HbA1c) at 6 weeks relative to the baseline value. Results: Ten patients completed the study. The difference between the mean within-subject changes in %HbA1c associated with 6-week periods of fluticasone and the mean changes associated with montelukast therapy was small but statistically significant (mean difference=0.25; P<0.025). Neither fluticasone nor oral montelukast therapy for 6 weeks led to a significantly different mean % HbA1c compared with the relevant baseline (mean differences=0.11 and −0.14, respectively). Conclusion: The absence of a clinically significant within-subject difference in the changes in %HbA1c associated with fluticasone versus oral montelukast therapy, or between either therapy or baseline does not warrant recommending changes in therapy for asthma or diabetes in patients with these co-morbid conditions. However, we suggest that clinicians carefully monitor blood glucose control when diabetic patients initiate ICS, especially with higher dosages.
Correlation between sweat glucose and blood glucose in subjects with diabetes.

BACKGROUND Sweat contains glucose that can accurately reflect blood glucose. However, skin surface glucose can confound these measurements. METHODS A perfusion method was used to rapidly harvest sweat from forearm sites on human subjects. The sweat samples were analyzed for glucose by high-performance liquid chromatography methods and compared with the results obtained with a blood glucose meter. RESULTS The results of 23 different studies of seven individual subjects with diabetes show a strong correlation between sweat glucose and blood glucose. CONCLUSION Sweat glucose, when properly harvested to prevent contamination from other sources on the skin's surface, can accurately reflect blood glucose levels.
Skin extensibility and consistency in patients with Ehlers–Danlos syndrome and benign joint hypermobility syndrome

Objectives: The reproducibility of clinical tests for skin extensibility and consistency, essential for differentiating between types of Ehlers–Danlos syndrome (EDS) and benign joint hypermobility syndrome (BJHS), is unknown. Paraclinical methods may provide objective differential diagnostic methods. Methods: Six EDS, 11 BJHS, and 19 controls completed the trial. We analysed the overall inter‐examiner agreement on clinical tests for skin extensibility and consistency, in addition to analyses on suction cup (SC) and soft tissue stiffness meter (STSM) methods. Results: Overall agreement on tests for skin extensibility and consistency varied between 0.44 and 0.72. Extensibility evaluated by SC showed an insignificant difference between EDS patients and controls (p = 0.056). Consistency evaluated by STSM showed significant differences (p = 0.001). Conclusions: Overall inter‐examiner agreement on clinical tests for skin extensibility and consistency was below 0.80, which was required a priori to conduct a reproducibility study. Further refinement of tests and a training phase are necessary. The SC and STSM results are encouraging but must be reproduced in a larger study population.
Mutational spectrum of congenital adrenal hyperplasia in Slovenian patients: a novel Ala15Thr mutation and Pro30Leu within a larger gene conversion associated with a severe form of the disease.

OBJECTIVE To analyse the mutational spectrum, the associated haplotypes and the genotype-phenotype correlation, and to design a reliable and rational approach for CYP21 mutation detection in Slovenian congenital adrenal hyperplasia (CAH) patients. DESIGN Molecular analysis of the CYP21 gene was performed in 36 CAH patients and 79 family members. METHODS Southern blotting, sequence-specific PCR amplification (PCR-SSP), sequence-specific oligonucleotide hybridisation (PCR-SSO) and sequencing were used to detect CYP21 gene deletions, conversions and point mutations. RESULTS CYP21 gene deletion was the most frequent mutation (36.4%). Large gene conversions detectable only by Southern blotting represented 12.1%, and gene conversions involving the promoter region represented 7.6% of the mutated alleles. The most frequent point mutations were: intron 2 splice mutation 16.7%, Ile172Asn mutation 7.6%, Gln318Stop 7.5% and Pro30Leu 12.2% of alleles. A correlation between the genotype and the clinical phenotype similar to those described for large populations was observed. The finding of Pro30Leu mutation linked to a gene conversion could explain the simple virilising (SV) phenotype in compound heterozygotes for the Pro30Leu and a severe mutation. In two siblings with a salt wasting form of CAH (SW-CAH), a novel mutation Ala15Thr was found on the allele characterised by Pro30Leu mutation and gene conversion involving the promoter region. CONCLUSIONS Our genotyping approach allowed reliable diagnosis of CAH in the Slovenian population. The high frequency of CYP21 gene aberrations on Pro30Leu positive alleles justified systematic searching for a gene conversion in the promoter region using the PCR-SSP reaction.
Reproducible RNA Preparation from Sugarcane and Citrus for Functional Genomic Applications

High-throughput functional genomic procedures depend on the quality of the RNA used. Copurifying molecules can negatively impact the functionality of some plant RNA preparations employed in these procedures. We present a simplified, rapid, and scalable SDS/phenol-based method that provides the high-quantity and -quality RNA required by the newly emerging biotechnology applications. The method is applied to isolating RNA from tissues of two biotechnologically important crop plants, sugarcane and citrus, which provide a challenge due to the presence of fiber, polysaccharides, or secondary metabolites. The RNA isolated by this method is suitable for several downstream applications including northern blot hybridization, microarray analysis, and quantitative RT-PCR. This method has been used in a diverse range of projects ranging from screening plant lines overexpressing mammalian genes to analyzing plant responses to viral infection and defense signaling molecules.
Visualizing competitive behaviors in multi-user virtual environments

We present a system for enhancing observation of user interactions in virtual environments. In particular, we focus on analyzing behavior patterns in the popular team-based first-person perspective game Return to Castle Wolfenstein: Enemy Territory. This game belongs to a genre characterized by two moderate-sized teams (usually 6 to 12 players each) competing over a set of objectives. Our system allows spectators to visualize global features such as large-scale behaviors and team strategies, as opposed to the limited, local view that traditional spectating modes provide. We also add overlay visualizations of semantic information related to the action that might be important to a spectator in order to reduce the information overload that plagues traditional overview visualizations. These overlays can visualize information about abstract concepts such as player distribution over time and areas of intense combat activity, and also highlight important features like player paths, fire coverage, etc. This added information allows spectators to identify important game events more easily and reveals large-scale player behaviors that might otherwise be overlooked.
Antibiotic Treatment Affects Intestinal Permeability and Gut Microbial Composition in Wistar Rats Dependent on Antibiotic Class

Antibiotics are frequently administered orally to treat bacterial infections not necessarily related to the gastrointestinal system. This has adverse effects on the commensal gut microbial community, as it disrupts the intricate balance between specific bacterial groups within this ecosystem, potentially leading to dysbiosis. We hypothesized that modulation of community composition and function induced by antibiotics affects intestinal integrity depending on the antibiotic administered. To address this a total of 60 Wistar rats (housed in pairs with 6 cages per group) were dosed by oral gavage with either amoxicillin (AMX), cefotaxime (CTX), vancomycin (VAN), metronidazole (MTZ), or water (CON) daily for 10–11 days. Bacterial composition, alpha diversity and caecum short chain fatty acid levels were significantly affected by AMX, CTX and VAN, and varied among antibiotic treatments. A general decrease in diversity and an increase in the relative abundance of Proteobacteria was observed for all three antibiotics. Additionally, the relative abundance of Bifidobacteriaceae was increased in the CTX group and both Lactobacillaceae and Verrucomicrobiaceae were increased in the VAN group compared to the CON group. No changes in microbiota composition or function were observed following MTZ treatment. Intestinal permeability to 4 kDa FITC-dextran decreased after CTX and VAN treatment and increased following MTZ treatment. Plasma haptoglobin levels were increased by both AMX and CTX but no changes in expression of host tight junction genes were found in any treatment group. A strong correlation between the level of caecal succinate, the relative abundance of Clostridiaceae 1 family in the caecum, and the level of acute phase protein haptoglobin in blood plasma was observed. In conclusion, antibiotic-induced changes in microbiota may be linked to alterations in intestinal permeability, although the specific interactions remain to be elucidated as changes in permeability did not always result from major changes in microbiota and vice versa.
Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013

Objective To quantify the dose-response associations between total physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events. Design Systematic review and Bayesian dose-response meta-analysis. Data sources PubMed and Embase from 1980 to 27 February 2016, and references from relevant systematic reviews. Data from the Study on Global AGEing and Adult Health conducted in China, Ghana, India, Mexico, Russia, and South Africa from 2007 to 2010 and the US National Health and Nutrition Examination Surveys from 1999 to 2011 were used to map domain specific physical activity (reported in included studies) to total activity. Eligibility criteria for selecting studies Prospective cohort studies examining the associations between physical activity (any domain) and at least one of the five diseases studied. Results 174 articles were identified: 35 for breast cancer, 19 for colon cancer, 55 for diabetes, 43 for ischemic heart disease, and 26 for ischemic stroke (some articles included multiple outcomes). Although higher levels of total physical activity were significantly associated with lower risk for all outcomes, major gains occurred at lower levels of activity (up to 3000-4000 metabolic equivalent (MET) minutes/week). For example, individuals with a total activity level of 600 MET minutes/week (the minimum recommended level) had a 2% lower risk of diabetes compared with those reporting no physical activity. An increase from 600 to 3600 MET minutes/week reduced the risk by an additional 19%. The same amount of increase yielded much smaller returns at higher levels of activity: an increase of total activity from 9000 to 12 000 MET minutes/week reduced the risk of diabetes by only 0.6%. Compared with insufficiently active individuals (total activity <600 MET minutes/week), the risk reduction for those in the highly active category (≥8000 MET minutes/week) was 14% (relative risk 0.863, 95% uncertainty interval 0.829 to 0.900) for breast cancer; 21% (0.789, 0.735 to 0.850) for colon cancer; 28% (0.722, 0.678 to 0.768) for diabetes; 25% (0.754, 0.704 to 0.809) for ischemic heart disease; and 26% (0.736, 0.659 to 0.811) for ischemic stroke. Conclusions People who achieve total physical activity levels several times higher than the current recommended minimum level have a significant reduction in the risk of the five diseases studied. More studies with detailed quantification of total physical activity will help to find more precise relative risk estimates for different levels of activity.
Hybrid Multi-FPGA board evaluation by limiting multi-hop routing

Multi-FPGA Boards (MFBs) have been in use for more than a decade for emulation of the digital circuits in many applications. Key feature of an MFB architecture is its inter-FPGA connections. There are two types of inter-FPGA connections namely: i) fixed connection (FC)-connecting a pair of FPGAs through a dedicated wire between them, ii) programmable connection (PC)-connecting a pair of FPGAs through a programmable switch like Field-Programmable Interconnect Device (FPID). Hence, a PC requires two wires compared to one wire in FC. Khalid et al. (1999) have shown that the MFBs consisting of both the types of connections (hybrid MFBs) are better than other architectures for emulation of the circuits, if the number of PCs are minimum required. Hence, we evaluate the hybrid MFBs for the required number of PCs as an evaluation metric. Availability of technology mapping, partitioning, embedding and routing tools is another important requirement for emulation. A routing tool (multi-hop router) prefers one or more unused FCs (multi-hops) in lieu of one PC. Available multihop routers are specific to MFB architecture and use unlimited hops in the routes. For evaluation, a generic multi-hop router for any hybrid architecture is required which obeys the given limit on maximum number of hops in every route. This paper presents the development of routing tool for the same. A heuristic, a lower bound and an optimal algorithm has been implemented for this purpose. For the test cases, it has been observed that the optimal results (within 3 hours) are achievable by the heuristic (within a minute). Also the results are more precise than the available results.
A constructive interpretation of the full set theory

The interpretation of the ZF set theory reported in this paper is, actually, part of a wider effort, namely, a new approach to the foundation of mathematics, which is referred to as The Cybernetic Foundation. A detailed exposition of the Cybernetic Foundation will be published elsewhere. Our approach leads to a full acceptance of the formalism of the classical set theory, but interprets it using only the idea of potential, but not actual (completed) infinity, and dealing only with finite objects that can actually be constructed. Thus we have a finitist proof of the consistency of ZF. This becomes possible because we set forth a metatheory of mathematics which goes beyond the classical logic and set theory and, of course, cannot be formalized in ZF, yet yields proofs which are as convincing—at least, from the author's viewpoint—as any mathematical proof can be. Our metatheory is based on the following two ideas. Firstly, we define the semantics of the mathematical language using the cybernetical concept of knowledge. According to this concept, to say that a cybernetic system (a human being, in particular) has some knowledge is to say that it has some models of reality. In the Cybernetic Foundation we consider mathematics as the art of constructing linguistic models of reality.
What have we learnt from using real parallel machines to solve real problems?

We briefly review some key scientific and parallel processing issues in a selection of some 84 existing applications of parallel machines. We include the MIMD hypercube transputer array, BBN Butterfly, and the SIMD ICL DAP, Goodyear MPP and Connection Machine from Thinking Machines. We use a space-time analogy to classify problems and show how a division into synchronous, loosely synchronous and asynchronous problems is helpful. This classifies problems into those suitable for SIMD or MIMD machines and isolates the asynchronous class as that for which major uncertainties as to possible parallelism exist. Interestingly about half of the scientific applications run excellently on SIMD machines with the other half able to take especial advantage of the MIMD architecture.
Public attitudes toward health information exchange: perceived benefits and concerns.

OBJECTIVES To characterize consumers' attitudes regarding the perceived benefits of electronic health information exchange (HIE), potential HIE privacy and security concerns, and to analyze the intersection of these concerns with perceived benefits. STUDY DESIGN A cross-sectional study. METHODS A random-digit-dial telephone survey of English-speaking adults was conducted in 2010. Multivariate logistic regression models examined the association between consumer characteristics and concerns related to the security of electronic health records (EHRs) and HIE. RESULTS A majority of the 1847 respondents reported they were either "very" or "somewhat" concerned about privacy of HIE (70%), security of HIE (75%), or security of EHRs (82%). Concerns were significantly higher (P <.05) among employed individuals 40 to 64 years old and minorities. Many believed that HIE would confer benefits such as improved coordination of care (89%). Overall, 75% agreed that the benefits of EHRs outweighed risks to privacy and security, and 60% would permit HIE for treatment purposes even if the physician might not be able to protect their privacy all of the time. Over half (52%) wanted to choose which providers access and share their data. CONCLUSIONS Greater participation by consumers in determining how HIE takes place could engender a higher degree of trust among all demographic groups, regardless of their varying levels of privacy and security concerns. Addressing the specific privacy and security concerns of minorities, individuals 40 to 64 years old, and employed individuals will be critical to ensuring widespread consumer participation in HIE.
Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population[S]

We investigated the effects of single nucleotide polymorphisms (SNPs) of the hepatic lipase gene (LIPC) on plasma HDL-cholesterol (HDL-C) levels in Turks, a population with low levels of HDL-C. All exons and six evolutionarily conserved regions from 28 Turkish subjects were sequenced. We found 51 SNPs, nine of which were novel. Those 51 SNPs and SNPs from the National Center for Biotechnology Information dbSNP were evaluated by bioinformatics approaches. The population frequencies and linkage disequilibrium among SNPs from HapMap were combined with results from transcriptional factor prediction tools and the literature to select SNPs for genotyping. We found that five tagging LIPC SNPs, two reported here for the first time, were significantly associated with plasma HDL-C levels in both men and women (n = 2,612). These results were replicated in a separate Turkish cohort (n = 1,164). Plasma HDL-C levels were higher in subjects homozygous for the minor alleles of rs4775041, rs1800588 (–514C>T), and rs11858164 and lower in subjects homozygous for the minor alleles of rs11856322 and rs2242061. These SNPs seemed to have independent and additive effects on plasma HDL-C levels (1.5–5.2 mg/dl). Hepatic lipase activity in a subset (n = 260) of the main cohort was also significantly associated with all five SNPs. Thus, five LIPC SNPs, two novel, are associated with plasma HDL-C levels and hepatic lipase activity in two cohorts of Turkish subjects.