Miracle-dz/UniFAR-FTUs huggingface dataset:
South African, urban youth narratives: resilience within community

South African youth in low-income, urbanised communities are exposed to high levels of daily stressors, which increase their risk to negative outcomes. Resiliency can provide avenues for youth to transcend adversity and may contribute to their positive development. To provide a deeper understanding of the pathways that adolescents use to overcome adversity, this paper examined future aspirations of South African youth and how these aspirations were connected to resiliency factors framed by their lived context. A phenomenological approach was used to explore the perceptions of high school students. Fourteen focus groups with girls and boys (N = 112) were conducted. Data were analysed using a thematic approach. Discussions of the harsh conditions undermining the community's future highlighted opportunities for improvement. Community connectedness, hope and altruism were prevalent in youth's responses and could be used to facilitate community and individual resiliency. Our overall findings have important implications for positive youth development efforts.
Down-regulation of GPX 3 is associated with favorable / intermediate karyotypes in de novo acute myeloid leukemia

Decreased glutathione peroxidase 3 (GPX3) expression has been identified in numerous solid tumors. However, GPX3 expression pattern in acute myeloid leukemia (AML) remains poorly known. Our study was intended to explore GPX3 expression status and further analyze the clinical relevance of GPX3 expression in AML. GPX3 mRNA level was detected by real-time quantitative PCR in 122 de novo AML patients and 44 normal controls. GPX3 transcript level was significantly decreased compared with normal controls (P < 0.001). The patients with low GPX3 expression had significantly higher hemoglobin and platelets than those with high GPX3 expression (P = 0.049 and 0.020). The frequency of low GPX3 expression in favorable karyotype (66%, 23/35) and intermediate karyotype (65%, 45/69) was higher than in poor karyotype (29%, 4/14) (P = 0.017). No significant differences were observed in both complete remission and overall survival between the GPX3 low-expressed and high-expressed patients (P > 0.05). Reduced GPX3 expression is associated with favorable/intermediate karyotypes but not with survival in de novo AML patients.
The nature, frequency and course of psychiatric disorders in the first year after traumatic brain injury: a prospective study

Background Psychiatric disorders are common following traumatic brain injury (TBI). However, few studies have examined the course of disorder development and the influence of pre-injury psychiatric history. The present study aimed to examine the frequency of, and association between, psychiatric disorders occurring pre- and post-injury, and to examine the post-injury course of disorders. Method Participants were 102 adults (75.5% male) with predominantly moderate-severe TBI. Participants were initially assessed for pre-injury and current disorders, and reassessed at 3, 6 and 12 months post-injury using the Structured Clinical Interview for DSM-IV Disorders (SCID). Results Over half of the participants had a pre-injury psychiatric disorder; predominantly substance use, mood, and anxiety disorders. In the first year post-injury, 60.8% of participants had a psychiatric disorder, commonly anxiety and mood disorders. Post-injury disorders were associated with the presence of a pre-injury history (p<0.01), with 74.5% of participants with a pre-injury psychiatric history experiencing a post-injury disorder, which commonly presented at initial assessment or in the first 6 months. However, 45.8% of participants without a pre-injury history developed a novel post-injury disorder, which was less likely to emerge at the initial assessment and generally developed later in the year. Conclusions Despite evidence that most post-injury psychiatric disorders represent the continuation of pre-existing disorders, a significant number of participants developed novel psychiatric disorders. This study demonstrates that the timing of onset may differ according to pre-injury history. There seem to be different trajectories for anxiety and depressive disorders. This research has important implications for identifying the time individuals are most at risk of psychiatric disorders post-injury.
Antimicrobial and Probiotic Properties of Yeasts: From Fundamental to Novel Applications

The yeasts constitute a large and heterogeneous group of microorganisms that are currently attracting increased attention from scientists and industry. Numerous and diverse biological activities make them promising candidates for a wide range of applications not limited to the food sector. In addition to their major contribution to flavor development in fermented foods, their antagonistic activities toward undesirable bacteria, and fungi are now widely known. These activities are associated with their competitiveness for nutrients, acidification of their growth medium, their tolerance of high concentrations of ethanol, and release of antimicrobial compounds such as antifungal killer toxins or “mycocins” and antibacterial compounds. While the design of foods containing probiotics (microorganisms that confer health benefits) has focused primarily on Lactobacillus and Bifidobacterium, the yeast Saccharomyces cerevisiae var. boulardii has long been known effective for treating gastroenteritis. In this review, the antimicrobial activities of yeasts are examined. Mechanisms underlying this antagonistic activity as well as recent applications of these biologically active yeasts in both the medical and veterinary sectors are described.
Daily reports of symptoms and negative affect: Not all symptoms are the same

The interplay between state negative affect (SNA) and somatic symptoms is well-established in daily life, but the nature of the association is unclear. Questions remain regarding the role, if any, that SNA plays apart from trait negative affect (TNA), the direction of the association, and whether the relationship with SNA varies according to symptom type. Associations between three constellations of somatic symptoms and SNA were examined in adults (N = 781) queried on eight consecutive evenings. Inter- and intra-individual variation in temporal and concurrent associations were examined, with models including both state and trait negative affect. All symptoms were related to concurrent measures of SNA. Lagged associations varied by symptom type. No lagged analyses including respiratory symptoms were significant. Prior pain symptoms predicted SNA, and prior SNA predicted pain and gastrointestinal symptoms. TNA, however, mediated the association between prior pain symptoms and SNA.
Enhancement of adenovirus transformation by treatment of hamster embryo cells with diverse chemical carcinogens.

Primary hamster embryo cells were treated with various chemical carcinogens before, or after, inoculation with an oncogenic adenovirus, simian adenovirus 7. The viral transformation frequency was increased from 3- to 10-fold by treatment with methyl methanesulfonate, methylazoxy-methanol acetate, N -methyl- N′ -nitro- N -nitrosoguanidine, and N -acetoxy-acetylaminofluorene; but no increase was demonstrated when cells were treated with N -nitrosodiethylamine, N -nitrosodimethylamine, or 2-acetylaminofluorene. The frequency of viral transformation increased linearly with chemical concentration until a maximum level was reached; however, higher concentrations decreased the transformation frequency relative to that observed with lower doses. It is suspected that the chemical carcinogens enhance viral transformation by interacting directly with the host cells, rendering them more susceptible to transformation by virus.
Craniofacial form and function in Metriorhynchidae (Crocodylomorpha: Thalattosuchia): modelling phenotypic evolution with maximum-likelihood methods

Metriorhynchid crocodylomorphs were the only group of archosaurs to fully adapt to a pelagic lifestyle. During the Jurassic and Early Cretaceous, this group diversified into a variety of ecological and morphological types, from large super-predators with a broad short snout and serrated teeth to specialized piscivores/teuthophages with an elongate tubular snout and uncarinated teeth. Here, we use an integrated repertoire of geometric morphometric (form), biomechanical finite-element analysis (FEA; function) and phylogenetic data to examine the nature of craniofacial evolution in this clade. FEA stress values significantly correlate with morphometric values representing skull length and breadth, indicating that form and function are associated. Maximum-likelihood methods, which assess which of several models of evolution best explain the distribution of form and function data on a phylogenetic tree, show that the two major metriorhynchid subclades underwent different evolutionary modes. In geosaurines, both form and function are best explained as evolving under ‘random’ Brownian motion, whereas in metriorhynchines, the form metrics are best explained as evolving under stasis and the function metric as undergoing a directional change (towards most efficient low-stress piscivory). This suggests that the two subclades were under different selection pressures, and that metriorhynchines with similar skull shape were driven to become functionally divergent.
Student Use of Out-of-Class Study Groups in an Introductory Undergraduate Biology Course

Self-formed out-of-class study groups may benefit student learning; however, few researchers have quantified the relationship between study group use and achievement or described changes in study group usage patterns over a semester. We related study group use to performance on content exams, explored patterns of study group use, and qualitatively described student perceptions of study groups. A pre- and posttest were used to measure student content knowledge. Internet-based surveys were used to collect quantitative data on exam performance and qualitative data on study group usage trends and student perceptions of study groups. No relationship was found between gains in content knowledge and study group use. Students who participated in study groups did, however, believe they were beneficial. Four patterns of study group use were identified: students either always (14%) or never (55%) used study groups, tried but quit using them (22%), or utilized study groups only late in the semester (9%). Thematic analysis revealed preconceptions and in-class experiences influence student decisions to utilize study groups. We conclude that students require guidance in the successful use of study groups. Instructors can help students maximize study group success by making students aware of potential group composition problems, helping students choose group members who are compatible, and providing students materials on which to focus their study efforts.
Magma Propagation at Piton de la Fournaise From Joint Inversion of InSAR and GNSS

Magma propagation is an unsteady process controlled by magma‐crust interaction. To provide information on its dynamics, we invert complementary ground deformation data spanning the 8 hr preceding the 26 May 2016 eruption at Piton de la Fournaise (PdF) volcano (La Réunion, France). Data are inverted using 3‐D boundary element models combined with a Monte Carlo inversion method. The final geometry of the displacement source is determined based on four interferograms spanning the whole propagation phase while the dynamics of the propagation is inferred from temporal inversion of continuous Global Navigation Satellite System (GNSS) data, using the final geometry as an a priori to constrain the source. The best modeled magma path consists in a 2,700‐m‐long sill located 800 m above sea level and connected to the eruptive fissure by a subvertical dike. The quick opening of the horizontal part of the intrusion could have been favored by limited flank sliding during the early stage of propagation. The intrusion then stalled for ∼5 hr, while pressure increased slightly, until final upward propagation and eruption. Volume budget suggests that the eruption was fed by a single batch of magma quickly disconnected from its source. The delay prior to the eruption may reflect a limited magma supply. Finally, two mechanisms, potentially acting together, might have favored the eruption: a driving role of magmatic gas and/or, as often observed at Piton de la Fournaise, an eastward flank slip.
Comparative analysis of Hox downstream genes in Drosophila

Functional diversification of body parts is dependent on the formation of specialized structures along the various body axes. In animals, region-specific morphogenesis along the anteroposterior axis is controlled by a group of conserved transcription factors encoded by the Hox genes. Although it has long been assumed that Hox proteins carry out their function by regulating distinct sets of downstream genes, only a small number of such genes have been found, with very few having direct roles in controlling cellular behavior. We have quantitatively identified hundreds of Hox downstream genes in Drosophila by microarray analysis, and validated many of them by in situ hybridizations on loss- and gain-of-function mutants. One important finding is that Hox proteins, despite their similar DNA-binding properties in vitro, have highly specific effects on the transcriptome in vivo, because expression of many downstream genes respond primarily to a single Hox protein. In addition, a large fraction of downstream genes encodes realizator functions, which directly affect morphogenetic processes, such as orientation and rate of cell divisions, cell-cell adhesion and communication, cell shape and migration, or cell death. Focusing on these realizators, we provide a framework for the morphogenesis of the maxillary segment. As the genomic organization of Hox genes and the interaction of Hox proteins with specific co-factors are conserved in vertebrates and invertebrates, and similar classes of downstream genes are regulated by Hox proteins across the metazoan phylogeny, our findings represent a first step toward a mechanistic understanding of morphological diversification within a species as well as between species.
Long-Term Care , Formal Home Health Care , and Informal Care

We use the 1993 wave of the AHEAD data set to estimate a gametheoretic model of families decisions concerning time spent caring for elderly individuals and Þnancial transfers for home health care. The outcome is a Nash equilibrium where each family member jointly determines his or her consumption, transfers for formal care, and time allocation  informal care, market work, and leisure. The estimates allow us to decompose the effects of parent and child characteristics into wage effects, quality of care effects, and burden effects. They also allow us to simulate the effects of a broad range of policies of current interest.
Simulated Greenland Surface Mass Balance in the GISS ModelE2 GCM: Role of the Ice Sheet Surface

The rate of growth or retreat of the Greenland and Antarctic ice sheets remains a highly uncertain component of future sea level change. Here we examine the simulation of Greenland ice sheet surface mass balance (GrIS SMB) in a development branch of the ModelE2 version of the NASA Goddard Institute for Space Studies (GISS) general circulation model (GCM). GCMs are often limited in their ability to represent SMB compared with polar region regional climate models. We compare ModelE2‐simulated GrIS SMB for present‐day (1996–2005) simulations with fixed ocean conditions, at a spatial resolution of 2° latitude by 2.5° longitude (~200 km), with SMB simulated by the Modèle Atmosphérique Régionale (MAR) regional climate model (1996–2005 at a 25‐km resolution). ModelE2 SMB agrees well with MAR SMB on the whole, but there are distinct spatial patterns of differences and large differences in some SMB components. The impacts of changes to the ModelE2 surface are tested, including a subgrid‐scale representation of SMB with surface elevation classes. This has a minimal effect on ice sheet‐wide SMB but corrects local biases. Replacing fixed surface albedo with satellite‐derived values and an age‐dependent scheme has a larger impact, increasing simulated melt by 60%–100%. We also find that lower surface albedo can enhance the effects of elevation classes. Reducing ModelE2 surface roughness length to values closer to MAR reduces sublimation by ~50%. Further work is required to account for meltwater refreezing in ModelE2 and to understand how differences in atmospheric processes and model resolution influence simulated SMB.
The epidemiology of hepatoblastoma

Few causes of hepatoblastoma have been conclusively identified, mainly due to the extreme rarity of the disease. Inherited conditions including Familial Adenomatous Polyposis and Beckwith–Wiedemann Syndrome dramatically raise risk of hepatoblastoma but account for few cases overall. A small number of case–control studies investigating risk factors for sporadic hepatoblastoma have been conducted to date. Although most of these studies feature fewer than 200 cases, several clues have emerged. Most notably there is a roughly 20‐fold increased risk of hepatoblastoma among children with very low birth weight (<1,500 g) and a doubling of risk among those with moderately low birth weight (1,500–2,500 g). A modicum of evidence points to a possible role of parental tobacco use prior to or during pregnancy in the causation of hepatoblastoma as well. Pediatr Blood Cancer 2012; 59: 776–779. © 2012 Wiley Periodicals, Inc.
Multi-scale reconstruction of implicit surfaces with attributes from large unorganized point sets

We present a new method for the multi-scale reconstruction of implicit surfaces with attributes from large unorganized point sets. The implicit surface is reconstructed by subdividing the global domain into overlapping local subdomains using a perfectly balanced binary tree, reconstructing the surface parts in the local subdomains from non-disjunct subsets of the points by variational techniques using radial basis functions, and hierarchically blending together the surface parts of the local subdomains by using a family of functions called partition of unity. The subsets of the points in the inner nodes of the tree for intermediate resolutions are obtained by thinning algorithms. The reconstruction is particularly robust since the number of data points in the partition of unity blending zones can be specified explicitly. Furthermore, the new reconstruction method is valid for discrete datasets in any dimension, so we can use it also to reconstruct continuous functions for the surface's attributes. In a short discussion, we evaluate the advantages and drawbacks of our reconstruction method compared to existing reconstruction methods for implicit surfaces.
Increased dopamine DRD4 receptor mRNA expression in lymphocytes of musicians and autistic individuals: bridging the music-autism connection.

BACKGROUND People with autistic spectrum disorder (ASD) are affected by a long-life disabling condition, characterized by communication deficits, severe impairments in social functioning, and stereotyped behaviors. Although ASD individuals display several problems in interactions, it has been reported that they may show a peculiar interest in music. Previous studies have suggested a pivotal role for the dopaminergic system in the psychobiology of reward, including the pleasure of music. DESIGN In the present study, we sought to investigate dopamine DRD3 and DRD4 receptor expression in peripheral blood lymphocytes of adult healthy musicians and age- and gender-matched patients with ASD against the background hypothesis that the dopaminergic system may contribute a biological cause to the reward dimensions of the musical experience in both healthy and autistic individuals. RESULTS ANOVA showed significant differences in DRD4 mRNA expression between the groups (P = 0.008). Post-hoc analysis showed significant differences between the control group and both musicians (P < 0.05) and ASD individuals (P < 0.05). No differences were found for DRD3 mRNA expression between the groups. CONCLUSION Our current results provide intriguing preliminary evidence for a possible molecular link between dopamine DRD4 receptor, music and autism, possibly via mechanisms involving the reward system and the appraisal of emotions.
Sustained Endocrine Gland–Derived Vascular Endothelial Growth Factor Levels Beyond the First Trimester of Pregnancy Display Phenotypic and Functional Changes Associated With the Pathogenesis of Pregnancy-Induced Hypertension

Pregnancy-induced hypertension diseases are classified as gestational hypertension, preeclampsia, or eclampsia. The mechanisms of their development and prediction are still to be discovered. Endocrine gland–derived vascular endothelial growth factor (EG-VEGF) is an angiogenic factor secreted by the placenta during the first trimester of human pregnancy that was shown to control trophoblast invasion, to be upregulated by hypoxia, and to be abnormally elevated in pathological pregnancies complicated with preeclampsia and intrauterine growth restriction. These findings suggested that sustaining EG-VEGF levels beyond the first trimester of pregnancy may contribute to pregnancy-induced hypertension. To test this hypothesis, osmotic minipumps delivering EG-VEGF were implanted subcutaneously into gravid OF1 (Oncins France 1) mice on day 11.5 post coitus, which is equivalent to the end of the first trimester of human pregnancy. Mice were euthanized at 15.5 and 18.5 days post coitus to assess (1) litter size, placental, and fetal weights; (2) placental histology and function; (3) maternal blood pressure; (4) renal histology and function; and (5) circulating soluble fms-like tyrosine kinase 1 and soluble endoglin. Increased EG-VEGF levels caused significant defects in placental organization and function. Both increased hypoxia and decreased trophoblast invasion were observed. Treated mice had elevated circulating soluble fms-like tyrosine kinase 1 and soluble endoglin and developed gestational hypertension with dysregulated maternal kidney function. EG-VEGF effect on the kidney function was secondary to its effects on the placenta as similarly treated male mice had normal kidney functions. Altogether, these data provide a strong evidence to confirm that sustained EG-VEGF beyond the first trimester of pregnancy contributes to the development of pregnancy-induced hypertension.
Quantification of regenerative potential in primary human mammary epithelial cells

We present an organoid regeneration assay in which freshly isolated human mammary epithelial cells are cultured in adherent or floating collagen gels, corresponding to a rigid or compliant matrix environment. In both conditions, luminal progenitors form spheres, whereas basal cells generate branched ductal structures. In compliant but not rigid collagen gels, branching ducts form alveoli at their tips, express basal and luminal markers at correct positions, and display contractility, which is required for alveologenesis. Thereby, branched structures generated in compliant collagen gels resemble terminal ductal-lobular units (TDLUs), the functional units of the mammary gland. Using the membrane metallo-endopeptidase CD10 as a surface marker enriches for TDLU formation and reveals the presence of stromal cells within the CD49fhi/EpCAM− population. In summary, we describe a defined in vitro assay system to quantify cells with regenerative potential and systematically investigate their interaction with the physical environment at distinct steps of morphogenesis. Summary: An assay in which single, freshly isolated human mammary epithelial cells are cultured in a matrix environment is developed and used to quantify the regenerative potential of human mammary cells.