Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgical management options and postoperative functional outcomes of petrous apex cholesteatoma

Abstract Conclusion: In cases of petrous apex (PA) cholesteatoma, radical removal should be prioritized over an unreasonable sparing of hearing or facial symmetry. Nevertheless, for patients with serviceable hearing and spared inner ear structures, conservative approaches may be applicable. Restoration of facial nerve (FN) function is achievable by reanimation procedures. Objectives: To analyze clinical manifestations, surgical techniques, and postoperative functional results of PA cholesteatoma. Methods: From 1987 to 2010, 13 cases of PA cholesteatoma underwent operations. Clinical, audiological, and radiological findings, surgical approach, and postoperative functional outcomes were analyzed retrospectively. Results: The most common symptoms were hearing loss and FN paralysis. All PA cholesteatomas extended to the middle ear; 10 (76.9%) through the anterior-superior route, whereas the other 3 (23.1%) were through the posterior-superior route. In 10 patients, labyrinthectomy was inevitable because of inner ear invasion. However, three limited cholesteatomas were removable via the middle cranial fossa or transmastoid approach without changing the bone-conduction threshold. Among six cases with FN paralysis, one underwent interposition graft, two FN decompression, and the others hypoglossal-FN anastomosis. One FN decompression case recovered to House-Brackmann grade I, and all other reanimation cases finally presented with grade IV. There were no major complications or recurrences during the follow-up period.
CAM-MAC: A Cooperative Asynchronous Multi-Channel MAC Protocol for Ad Hoc Networks

Medium access control (MAC) protocols have been studied under different contexts for several years now. In all these MAC protocols, nodes make independent decisions on when to transmit a packet and when to back-off from transmission. In this paper, we introduce the notion of node cooperation into MAC protocols. Cooperation adds a new degree of freedom which has not been explored before. Specifically we study the design of cooperative MAC protocols in an environment where each node is equipped with a single transceiver and has multiple channels to choose from. Nodes cooperate by helping each other select a free channel to use. We show that this simple idea of cooperation has several qualitative and quantitative advantages. Our cooperative asynchronous multi-channel MAC protocol (CAM-MAC) is extremely simple to implement and, unlike other multi-channel MAC protocols, is naturally asynchronous. We conduct extensive simulation experiments. We first compare CAM-MAC with IEEE 802.11b and a version of CAM-MAC with the cooperation element removed. We use this to show the value of cooperation. Our results show significant improvement in terms of number of collisions and throughput for CAM-MAC. We also compare our protocol with MMAC and SSCH and show that CAM-MAC significantly outperforms both of them.
Biological nitrogen fixation: rates, patterns and ecological controls in terrestrial ecosystems

New techniques have identified a wide range of organisms with the capacity to carry out biological nitrogen fixation (BNF)—greatly expanding our appreciation of the diversity and ubiquity of N fixers—but our understanding of the rates and controls of BNF at ecosystem and global scales has not advanced at the same pace. Nevertheless, determining rates and controls of BNF is crucial to placing anthropogenic changes to the N cycle in context, and to understanding, predicting and managing many aspects of global environmental change. Here, we estimate terrestrial BNF for a pre-industrial world by combining information on N fluxes with 15N relative abundance data for terrestrial ecosystems. Our estimate is that pre-industrial N fixation was 58 (range of 40–100) Tg N fixed yr−1; adding conservative assumptions for geological N reduces our best estimate to 44 Tg N yr−1. This approach yields substantially lower estimates than most recent calculations; it suggests that the magnitude of human alternation of the N cycle is substantially larger than has been assumed.
Adolescence and health

Preface ix Chapter 1 Understanding Adolescent Health 1 John Coleman, Leo B. Hendry and Marion Kloep Chapter 2 Young People: Physical Health, Exercise and Recreation 19 Ruth Lowry, John Kremer and Karen Trew Chapter 3 Emotional Health and Well-Being 41 John Coleman Chapter 4 Eating Disorders, Dieting and Body Image 61 Susan Faulkner Chapter 5 Sexual Health 83 Lester Coleman Chapter 6 Substance Use in Adolescence 107 Rutger C.M. E. Engels and Regina van den Eijnden Chapter 7 Getting It Right in Health Services for Young People 123 Aidan Macfarlane and Ann McPherson Chapter 8 Being Different: Adolescents, Chronic Illness and Disability 143 Peter J. Helms Chapter 9 Transitions for Young People with Complex Health Needs 159 Janet McDonagh Chapter 10 Health Promotion and Health Education 177 Donna Mackinnon Chapter 11 Conclusion 199 John Coleman, Leo B. Hendry and Marion Kloep Glossary 209 References 215 Index 231
[The relation between health-related quality of life and pain, depression, anxiety, and functional independence in persons with chronic physical disability].

OBJECTIVES This study was designed to investigate the relation between health- related quality of life and pain, depression, anxiety, and functional independence. METHODS The study included 82 healthy subjects aged 38.18+/-11.06 and 89 physically disabled subjects aged 37.72+/-16.40. Physical and social characteristics of the subjects such as age, height, length, weight, gender, occupational and marital status, and level of education were recorded. Visual Analogue Scale, Beck Depression Inventory, Beck Anxiety Inventory, Nottingham Health Profile, and Functional Independence Measure were used to evaluate pain, depression, anxiety, quality of life, and functional independence, respectively. RESULTS Compared to healthy individuals, chronically disabled subjects had higher pain, depression and anxiety and lower quality of life scores. Between-group comparison showed that there was a significant difference in pain, depression, anxiety levels and health-related quality of life (p<0.05). Similarly, both healthy and disabled individuals indicated a negative correlation between pain, depression, anxiety and quality of life (p<0.05). CONCLUSION In individuals with chronic disabilities, pain may induce serious psychological problems, negatively affecting quality of life. This study showed that in chronically disabled individuals, there is a strong correlation between pain, depression, anxiety, and quality of life. These results should be considered carefully when planning assessment and rehabilitation programs for individuals with chronic disabilities.
The role of fluorine-18 and strontium-87m scintigraphy in the management of infective spondylitis.

1. An ancillary diagnostic technique using Fluorine-l8 or Strontium-87m is described, and has assisted in the correct diagnosis of fifty-two patients admitted with the provisional diagnosis of infective spondylitis. 2. The technique is of particular value in the assessment of reactivation of chronic spinal infections and in the differential diagnosis of atypical lesions.
Experiences with a two terminal-pair digital impedance bridge

Describes the realization and preliminary tests of a two terminal-pair digital impedance bridge. The bridge, with a very simple architecture, is based on a commercial two-channel digital signal synthesizer, and a synchronous detector. The bridge can perform comparisons between impedances having arbitrary phase and magnitude ratio: its balance is achieved automatically in less than a minute. R-C comparisons with calibrated standard, at kHz frequency and 100 kΩ magnitude level, give ratio errors of the order of 10-5, with potential for further improvements.
Cued to Act on Impulse: More Impulsive Choice and Risky Decision Making by Women Susceptible to Overeating after Exposure to Food Stimuli

There is increasing evidence that individual differences in tendency to overeat relate to impulsivity, possibly by increasing reactivity to food-related cues in the environment. This study tested whether acute exposure to food cues enhanced impulsive and risky responses in women classified on tendency to overeat, indexed by scores on the three factor eating questionnaire disinhibition (TFEQ-D), restraint (TFEQ-R) and hunger scales. Ninety six healthy women completed two measures of impulsive responding (delayed discounting, DDT and a Go No-Go, GNG, task) and a measure of risky decision making (the balloon analogue risk task, BART) as well as questionnaire measures of impulsive behaviour either after looking at a series of pictures of food or visually matched controls. Impulsivity (DDT) and risk-taking (BART) were both positively associated with TFEQ-D scores, but in both cases this effect was exacerbated by prior exposure to food cues. No effects of restraint were found. TFEQ-D scores were also related to more commission errors on the GNG, while restrained women were slower on the GNG, but neither effect was modified by cue exposure. Overall these data suggest that exposure to food cues act to enhance general impulsive responding in women at risk of overeating and tentatively suggest an important interaction between tendency for impulsive decision making and food cues that may help explain a key underlying risk factor for overeating.
Determinants of adult age differences on synthetic work performance.

Synthetic work research is designed to simulate complex work activities by requiring participants to perform several concurrent tasks. The current project consisted of 2 studies in which adults of different ages performed 4 tasks during 25 sessions in a synthetic work situation in 5-min periods across 3 days. Large age differences were evident in the total score in both studies, and they were maintained across all stages of practice. Detailed analyses revealed that with increased age adults in this time management activity were less likely to perform self-paced tasks and to attempt difficult auditory discrimination judgments. Very little independent age-related influences were evident after the initial few sessions on the task. More than 70% of the age-related variance after nearly 2 hr of practice was shared with measures of processing speed obtained before performing the tasks. These results suggest that age-related differences in basic processing efficiency may be responsible for a large proportion of the age-related influences on the performance of moderately complex activities presumed to be similar to those likely to be encountered in a variety of work situations. A potential implication of the results of these studies is that increased age is likely to be a disadvantage in at least the initial phases of performance in many jobs. '
Bitcoin Mining Pools: A Cooperative Game Theoretic Analysis

Bitcoin is an innovative decentralized cryptocurrency whose core security relies on a "proof of work" procedure, which requires network participants to repeatedly compute hashes on inputs from a large search space. Finding one of the rare inputs that generates an extremely low hash value is considered a successful attempt, allowing miners to approve new transactions and, in return, to collect rewards in bitcoins. This reward allocation, which provides the incentive for miners to participate, is a random process with a large variance. Miners who desire a steady income thus often participate in mining pools that divide among their members the earned rewards, and reduce this variance. Mining pools are slightly better at coordinating participants due to lower-latency communication, a fact which implies that they manage to collect slightly higher rewards. We examine dynamics of pooled mining and the rewards that pools manage to collect, and use cooperative game theoretic tools to analyze how pool members may share these rewards. We show that for some network parameters, especially under high transaction loads, it is difficult or even impossible to distribute rewards in a stable way: some participants are always incentivized to switch between pools.
Return to the ED and hospitalisation following minor injuries among older persons treated in the emergency department: predictors among independent seniors within 6 months.

BACKGROUND minor traumatic injuries among independent older people have received little attention to date, but increasingly the impact of such injuries is being recognised. OBJECTIVES we assessed the frequency and predictors of acute health care use, defined as return to the emergency department (ED) or hospitalisation. STUDY DESIGN national multicentre prospective observational study. SETTING eight Canadian teaching EDs between April 2009 and April 2013. PARTICIPANTS a total of 1,568 patients aged 65-100 years, independent in basic activities of daily living, discharged from ED following a minor traumatic injury. METHODS trained assessors measured baseline data including demographics, functional status, cognition, comorbidities, frailty and injury severity. We then conducted follow-up telephone interviews at 6 months to assess subsequent acute health care use. We used log-binomial regression analyses to identify predictors of acute health care use, and reported relative risks and 95% CIs. RESULTS participants' mean age was 77.0, 66.4% female, and their injuries included contusions (43.5%), lacerations (25.1%) and fractures (25.4%). The cumulative rate of acute health care use by 6 months post-injury was 21.5% (95% CI: 19.0-24.3%). The strongest predictors of acute health care use within 6 months were cognitive impairment, RR = 1.6 (95% IC: 1.2-2.1) and the mechanism of injury including pedestrian struck or recreational injuries, RR = 1.6 (95% CI 1.2-2.2). CONCLUSIONS among independent community living older persons with a minor injury, cognitive impairment and mechanism of injury were independent risk factors for acute healthcare use. Future studies should look at whether tailored discharge planning can reduce the need for acute health care use.
New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain

In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
Biomarkers of Inflammation and Axonal Degeneration/Damage in Patients with Newly Diagnosed Multiple Sclerosis: Contributions of the Soluble CD163 CSF/Serum Ratio to a Biomarker Panel

Background Expression of soluble CD163 (sCD163), a macrophage/microglia biomarker, is increased in inflammatory conditions, and sCD163 levels in the cerebrospinal fluid (CSF) have recently been shown to be elevated in patients with multiple sclerosis (MS): the sCD163 CSF/serum ratio was elevated in patients with relapsing-remitting MS (RRMS), primary progressive MS (PPMS), and clinically isolated syndrome (CIS) compared with symptomatic controls. Objective To investigate the contributions of the sCD163 CSF/serum ratio to a biomarker panel focusing on inflammation and axonal degeneration in newly diagnosed MS; thus optimising a diagnostic biomarker panel for MS. Methods After a full MS diagnostic work-up, including collection of paired samples of CSF and serum, 125 patients were included in this study. Patients were divided into groups based on their diagnosis, and patients with normal clinical and paraclinical findings were defined as symptomatic controls. Serum and CSF levels, ratios, and indices of sCD163, CXCL13, osteopontin, neopterin, and CSF levels of neurofilament light polypeptide were determined by enzyme-linked immunosorbent assays (ELISAs). For sCD163 the results constitute a post-hoc analysis of already published data. Results All tested biomarkers, notably the sCD163 ratio, the CXCL13 ratio, the NEO ratio, the CSF level of NfL, the IgG index, and the serum level of OPN, were significantly correlated to RRMS, PPMS, and/or CIS. The individual biomarkers in single tests had a lower performance than the IgG index, however, their combined receiver operating characteristic (ROC) curve demonstrated excellent diagnostic discriminatory power. Conclusion The biomarker panel showed distinct profiles for each patient group and could be a valuable tool for clinical differentiation of MS subgroups. The combined ROC analysis showed that sCD163 contributes positively as a diagnostic marker to a panel of established MS biomarkers. Patients with PPMS were demonstrated to have significantly elevated levels of both inflammatory and degenerative markers.
Rational Combination Therapy of Vintafolide (EC145) with Commonly Used Chemotherapeutic Drugs

Purpose: When evaluated in patients with ovarian and other cancer, vintafolide (EC145), a potent folate-targeted vinca alkaloid conjugate, displayed a toxicity profile that seemed to be nonoverlapping with many standard-of-care cancer therapeutics. It was, therefore, hypothesized that combining vintafolide with certain approved anticancer drugs may afford greater therapeutic efficacy compared with single-agent therapy. To explore this concept, vintafolide was evaluated in combination with pegylated liposomal doxorubicin (PLD; DOXIL), cisplatin, carboplatin, paclitaxel, docetaxel, topotecan, and irinotecan against folate receptor (FR)–positive models. Experimental Design: FR-expressing KB, M109, IGROV, and L1210 cells were first exposed to graded concentrations of vintafolide, either alone or in combination with doxorubicin (active ingredient in PLD), and isobologram plots and combination index values generated. The vintafolide combinations were also studied in mice bearing various FR-expressing tumors. Results: Vintafolide displayed strong synergistic activity against KB cells when combined with doxorubicin, and no less-than-additive effects resulted when tested against M109, IGROV, and L1210 cells. In contrast, when either desacetylvinblastine hydrazide (DAVLBH; the vinca alkaloid moiety in vintafolide) or vindesine (the vinca alkaloid most structurally similar to DAVLBH) were tested in combination with doxorubicin, less-than-additive antitumor effects were observed. In vivo, all vintafolide drug combinations produced far greater antitumor effect (complete responses and cures) compared with the single agents alone, without significant increase in overall toxicity. Importantly, these benefits were not observed with combinations of PLD and DAVLBH or vindesine. Conclusions: On the basis of these encouraging preclinical results, clinical studies to evaluate vintafolide drug combination therapies are now under way. Clin Cancer Res; 20(8); 2104–14. ©2014 AACR.
Steatosis in Hepatitis C: The Missing Link to Metabolic Abnormalities?

Despite significant advances in hepatitis C (HCV) research over the past 15 yr, a number of infected patients will develop complications and will not respond to antiviral therapy. Metabolic abnormalities and hepatic steatosis in HCV patients emerged recently as cofactors in the development of complications and in failure of therapy and have gained increasing attention of HCV investigators worldwide. Understanding the link between HCV and metabolic abnormalities will certainly provide novel therapeutic targets in the future. In this issue of the journal, a group of investigators demonstrated that the association of hepatic steatosis to metabolic abnormalities in HCV patients is not limited to adults but also present in children. These observations will likely be useful in understanding the applicability of novel approaches to all HCV patients regardless of their age group.
Alterations in the rat forebrain apoptosis following exposure to ionizing radiation

Ionizing radiation commonly used in the radiotherapy of brain tumours can cause adverse side effects to surrounding normal brain tissue. The most significant response of adult brain to radiation damage is induction of apoptosis. The adult mammalian subventricular zone (SVZ) of the brain lateral ventricles (LV) and their subsequent lateral ventricular extension, the rostral migratory stream (RMS), is one of the few areas, which retains the ability to generate new neurons and glial cells throughout life. Taking into account the fact, that ionizing radiation is one of the strongest exogenous factors affecting cell proliferation, the aim of the present study was to investigate the occurrence of radiation-induced apoptosis in this neurogenic region. Adult male Wistar rats were investigated 1, 5 or 10 days after single whole-body gamma irradiation with the dose of 3 Gy. Apoptotic cell death was determined by in situ labelling of DNA nick ends (TUNEL) and fluorescence microscopy evaluation of TUNEL-positive cells. Considerable increase of apoptotic TUNEL-positive cells was observed 24 hrs after irradiation in caudal parts of RMS; i.e. in the vertical arm and elbow of RMS. Initial increase was followed by strong reduction of apoptosis in the RMS and by secondary over-accumulation of apoptotic cells in the animals that survived ten days after exposure. Results showed, that the proliferating population of cells, arisen in SVZ are highly sensitive to radiation-induced apoptosis. This observation should have implications for clinical radiotherapy to avoid complications in therapeutic brain irradiation.
Unweighted Stochastic Local Search can be Effective for Random CSP Benchmarks

We present ULSA, a novel stochastic local search algorithm for random binary constraint satisfaction problems (CSP). ULSA is many times faster than the prior state of the art on a widely-studied suite of random CSP benchmarks. Unlike the best previous methods for these benchmarks, ULSA is a simple unweighted method that does not require dynamic adaptation of weights or penalties. ULSA obtains new record best solutions satisfying 99 of 100 variables in the challenging frb100-40 benchmark instance.