Miracle-dz/UniFAR-FTUs huggingface dataset:
An investigation of haemocyanin oxygen affinity in the semi-terrestrial crab Ocypode saratan Forsk

SUMMARY The oxygen affinity of the haemocyanin in the supralittoral crab Ocypode saratan was investigated at temperatures between 20 and 35 °C. The effect of L-lactate on dialysed and undialysed haemolymph oxygen affinity was also examined. In general, the temperature sensitivity of the haemocyanin was low: AH was — 3'lkJmoF 1 , between 25 and 30°C. Temperature sensitivity was temperature-dependent, being larger at the extreme temperatures (AH = — 26kjmol~ 1 ). The Bohr effect (AlogPso/ApH) was temperatureindependent and averaged — 0-67. No specific effect of CO2 on oxygen affinity was observed but L-lactate increased oxygen affinity in both dialysed and undialysed haemolymph. The maximal effect of lactate on oxygen affinity was similar in dialysed and undialysed haemolymph, but was evident at a lower lactate concentration (4mmoir 1 ) in dialysed, compared with undialysed, haemolymph (7mmoll~ 1 ). Dialysed haemolymph showed a higher oxygen affinity than undialysed haemolymph at low lactate concentration (<4mmoll~ 1 ). The Bohr effect and buffer value both decreased with increasing lactate concentration in both dialysed and undialysed haemolymph. The physiological implications of these findings are discussed.
From Revolutionary Dreams to Organizational Fragmentation: Disputes over Violence within ETA and Sendero Luminoso

This article examines the evolution of ETA and Shining Path and the leaders' early theoretical justifications for armed action and the views of dissenters. Although both organizations emerged under similar circumstances, members of each differed in how they thought about violent politics. This resulted in different types and amounts of violence. Leaders revised their thinking amid constitutional change, fierce government repression and the entrance of new generations of activists. The two cases corroborate several recent scholarly theses - in particular, hypotheses about the ubiquity of discord and the propensity toward fragmentation within movements that use violence - and suggest new hypotheses about the role of leadership in the evolution of revolutionary movements.
Involvement of IQGAP1, an Effector of Rac1 and Cdc42 GTPases, in Cell-Cell Dissociation during Cell Scattering

ABSTRACT We have previously proposed that IQGAP1, an effector of Rac1 and Cdc42, negatively regulates cadherin-mediated cell-cell adhesion by interacting with β-catenin and by causing the dissociation of α-catenin from cadherin–β-catenin–α-catenin complexes and that activated Rac1 and Cdc42 positively regulate cadherin-mediated cell-cell adhesion by inhibiting the interaction of IQGAP1 with β-catenin. However, it remains to be clarified in which physiological processes the Rac1-Cdc42-IQGAP1 system is involved. We here examined whether the Rac1-IQGAP1 system is involved in the cell-cell dissociation of Madin-Darby canine kidney II cells during 12-O-tetradecanoylphorbol-13-acetate (TPA)- or hepatocyte growth factor (HGF)-induced cell scattering. By using enhanced green fluorescent protein (EGFP)-tagged α-catenin, we found that EGFP–α-catenin decreased prior to cell-cell dissociation during cell scattering. We also found that the Rac1-GTP level decreased after stimulation with TPA and that the Rac1-IQGAP1 complexes decreased, while the IQGAP1–β-catenin complexes increased during action of TPA. Constitutively active Rac1 and IQGAP1 carboxyl terminus, a putative dominant-negative mutant of IQGAP1, inhibited the disappearance of α-catenin from sites of cell-cell contact induced by TPA. Taken together, these results indicate that α-catenin is delocalized from cell-cell contact sites prior to cell-cell dissociation induced by TPA or HGF and suggest that the Rac1-IQGAP1 system is involved in cell-cell dissociation through α-catenin relocalization.
Generalization and Equilibrium in Generative Adversarial Nets (GANs)

We show that training of generative adversarial network (GAN) may not have good generalization properties; e.g., training may appear successful but the trained distribution may be far from target distribution in standard metrics. However, generalization does occur for a weaker metric called neural net distance. It is also shown that an approximate pure equilibrium exists in the discriminator/generator game for a special class of generators with natural training objectives when generator capacity and training set sizes are moderate. This existence of equilibrium inspires MIX+GAN protocol, which can be combined with any existing GAN training, and empirically shown to improve some of them.
Scalable Time-Decaying Adaptive Prediction Algorithm

Online learning is used in a wide range of real applications, e.g., predicting ad click-through rates (CTR) and personalized recommendations. Based on the analysis of users' behaviors in Video-On-Demand (VoD) recommender systems,we discover that the most recent users' actions can better reflect users' current intentions and preferences. Under this observation, we thereby propose a novel time-decaying online learning algorithm derived from the state-of-the-art FTRL-proximal algorithm, called Time-Decaying Adaptive Prediction (TDAP) algorithm. To scale Big Data, we further parallelize our algorithm following the data parallel scheme under both BSP and SSP consistency model. We experimentally evaluate our TDAP algorithm on real IPTV VoD datasets using two state-of-the-art distributed computing platforms, TDAP achieves good accuracy: it improves at least 5.6% in terms of prediction accuracy, compared to FTRL-proximal algorithm; and TDAP scales well: it runs 4 times faster when the number of machines increases from 2 to 10.
Role of E-selectin for diagnosing myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia

Backgrounds Effects of myocardial injury on E-selectin remain unclear. Thus, we investigated the diagnostic value of E-selectin for myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia. Methods In this prospective and blinded clinical study, plasma E-selectin, cardiac troponin I, creatine kinase isoenzyme MB, interleukin-6 and tumor necrosis factor alpha concentrations were measured in paediatric patients with mycoplasma pneumoniae pneumonia (MPP group, n = 138). The control group comprised 120 healthy children. The definition of cardiac injury was based on cardiac troponin I or CK-MB (with or possibly without abnormal electrocardiogram evidence). Diagnostic value of E-selectin for myocardial injury was determined by analysing receiver operating characteristic curves. Results Among the 138 mycoplasma pneumoniae pneumonia patients, 40 patients were identified with myocardial injury, while 98 patients were identified without myocardial injury. Plasma E-selectin concentrations were: 40.22 ± 4.80 ng/mL, in patients with myocardial injury; 18.55 ± 2.16 ng/mL, in patients without myocardial injury and 12.39 ± 3.27 ng/mL, in healthy children. For the 40 patients identified with myocardial injury, area under the receiver operating characteristic curve value for plasma E-selectin concentrations was 0.945 (95% CI: 0.899–0.991), and optimal diagnostic cut-off value was 29.93 ng/mL (positive likelihood ratio = 72.5). Conclusion E-selectin was shown to be an effective index for myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia, and its role in other causes of myocardial injury warrants further investigation.
Pseudomonas syringae hijacks plant stress chaperone machinery for virulence

Plant heat shock protein Hsp70 is the major target of HopI1, a virulence effector of pathogenic Pseudomonas syringae. Hsp70 is essential for the virulence function of HopI1. HopI1 directly binds Hsp70 through its C-terminal J domain and stimulates Hsp70 ATP hydrolysis activity in vitro. In plants, HopI1 forms large complexes in association with Hsp70 and induces and recruits cytosolic Hsp70 to chloroplasts, the site of HopI1 localization. Deletion of a central P/Q-rich repeat region disrupts HopI1 virulence but not Hsp70 interactions or association with chloroplasts. Thus, HopI1 must not only bind Hsp70 through its J domain, but likely actively affects Hsp70 activity and/or specificity. At high temperature, HopI1 is dispensable for P. syringae pathogenicity, unless excess Hsp70 is provided. A working hypothesis is that Hsp70 has a defense-promoting activity(s) that HopI1 or high temperature can subvert. Enhanced susceptibility of Hsp70-depleted plants to nonpathogenic strains of P. syringae supports a defense-promoting role for Hsp70.
Male-biased transmission of deleterious mutations to the progeny in Arabidopsis thaliana

The extent and cause of male-biased mutation rates, the higher number of mutations in sperm than in eggs, is currently an active and controversial subject. Recent evidence indicates that this male (sperm) bias not only occurs in animals but also in plants. The higher mutation rate in plant sperm was inferred from rates of evolution of neutral DNA regions, and the results were confined to the mitochondria and chloroplasts of gymnosperms. However, the relative transmission rates of deleterious mutations, which have substantial evolutionary consequences, have rarely been studied. Here, an investigation is described by using the hermaphroditic self-compatible flowering plant Arabidopsis thaliana, in which we artificially increased the rate of mutation in pollen (i.e., sperm donor) and maternal (i.e., egg donor) parents, by using two kinds of UV irradiation in parallel and separate experiments, and assessed the deleterious effects on fitness of the F2 generation. The results show that more deleterious induced mutations are transmitted to the progeny by a sperm than by an egg. These findings provide the first experimental evidence that more deleterious mutations are inherited from sperm than from an egg in any organism. Possible causes underlying this male bias are discussed.
Assessment of the oral health status of asthmatic children

ABSTRACT Objectives: To assess the oral health status and salivary composition in a group of children suffering from bronchial asthma. Materials and Methods: The sample consisted of sixty asthmatic children, sixty healthy negative controls, and sixty healthy positive controls of both sexes with age ranging from 4 to 12 years old. The asthmatics were grouped according to disease severity into mild, moderate, or severe asthmatic. All the children were clinically examined to assess their dental caries experience (decayed, indicated for extraction, and filled primary tooth [def] and decayed-missing-filled permanent tooth [DMF]), dental erosion condition (tooth wear index), and gingival health condition (gingival index [GI]). Salivary samples were collected and assessed for salivary flow rate, salivary pH, and the level of calcium, sodium, and potassium. Results: The results of this study revealed that asthmatic children presented significantly higher def, DMF score, and GI mean values compared to the control groups. Severe asthmatics significantly presented the highest def and GI score. Salivary analysis revealed reduced stimulated salivary flow rate and altered salivary pH. In addition, significantly elevated mean salivary calcium level found to be associated with higher GI mean score. Conclusions: Children suffering from bronchial asthma should receive special dental preventive attention as presented with greater risk for oral and dental diseases as compared to the healthy controls.
Bit rate matching for energy efficient optical networks

Energy consumption of WDM transmitter/receiver, ROADM, IP routers, EDFA, DCM . is firstly performed. Then, considering a point to point link and a meshed network, an energy per bit consumption analysis permits to conclude which bit rate (40Gb/s, 100Gb/s or mixed line rate 40/100Gb/s) is better adapted to optimize the energy efficiency of the considered systems.
Stress-Induced Capacitance of Partially Depleted MOSFETs from Ring Oscillator Delay

SUMMARY In the current study, stress-induced capacitance determined by direct measurement on MOSFETs was compared with that determined by indirect simulation through the delay of CMOS ring oscillators (ROs) fabricated side by side with MOSFETs. External compressive stresses were applied on � 110� silicon-on-insulator (SOI) n-/p-MOSFETs with the ROs in a longitudinal configuration. The measured gate capacitance decreased as the compressive stress on SOI increased, which agrees with the result of the capacitance difference between measured and simulated delay of the ROs. The oscillation frequency shift of the ROs should mainly be attributed to oxide capacitance, aside from the change in mobility of the n-/p-MOSFETs. The result suggests that the stress-induced gate capacitance of partially depleted MOSFETs is an important factor for the capacitance shift in a circuit and that ROs can be used in a vehicle to determine mechanical stress-induced gate capacitance in MOSFETs.
Psikolojik Sermayenin Çalışanların Duygu Gösterimleri Ve İşe Yabancılaşmalarına Etkileri: Sağlık Sektöründe Bir Araştırma

Bu arastirmada, psikolojik sermayenin, duygusal emek ve ise yabancilasma uzerine etkileri arastirilmistir. Ayrica psikolojik sermaye ile ise yabancilasma arasinda duygusal emegin aracilik rolune bakilmistir. Bu maksatla, Ankara’da ozel ve kamu saglik sektorunde gorev yapan 187 katilimcidan anket yoluyla elde edilen verilerden istifade edilmistir. Calismada degiskenler arasi iliskiler ve etkileri korelâsyon ve regresyon analizleri ile ortaya konurken, degiskenlere ait olceklerin dogrulanmasi esnasinda yapisal esitlik modeli kullanilmistir. Bulgulara gore, psikolojik sermayenin duygusal emek alt boyutlari ile ise yabancilasma uzerinde onemli etkilere sahip oldugu gorulmustur. Ozellikle oz yeterliligi yuksek olanlar ile umutlu ve iyimser calisanlarin yuzeysel rol yapmalari ile ise yabancilasmalari dusuk iken, dogal duygu gosterimleri yuksek olarak tespit edilmistir. Psikolojik sermayenin genel olarak ise yabancilasmayi engelledigi gorulmustur. Ayrica, katilimcilarin duygusal emeklerinin psikolojik sermaye ve ise yabancilasma arasinda anlamli aracilik rolune rastlanilmamistir. Anahtar Kelimeler: Psikolojik Sermaye, Duygusal Emek, Ise Yabancilasma Jel Kodlari: D23, M12 ABSTRACT In this study, the effects of psychological capital to emotional displays and work alienation are examined. And if available, the mediating role of emotional labor between psychological capital and work alienation are also observed. For this purpose, data are obtained and analyzed from 187 private and public hospital employees working in Ankara. The relations and effects between variables are presented by correlation and regression analyses. The validity of scales is measured with structural equation model. According to the findings, it is seen that psychological capital of hospital employees has significant effects on their emotional labor sub-dimensions and work alienation. Particularly, it is found that when self-efficacy is sufficient and hope and optimism are high, the employees’ surface acting and work alienation are low, but natural emotional displays are high. In general, it is found that psychological capital restrains work alienation. And also, it is observed that participants’ emotional labor do not have any mediating role between psychological capital and work alienation. Key Words: Psychological Capital , Emotional Labor, Work Alienation Jel Codes : D23, M12
Forecasting data centers power consumption with the Holt-Winters method

Data centers are rapidly increasing in the last few years and this trend will continue in the future due to the market demand for virtual infrastructures, cloud services and IoT applications. The whole ICT sector is faced with an energy efficiency challenge and data centers represent a significant share of all ICT-related emissions. Improving energy efficiency has therefore become a critical objective for ICT infrastructures and equipment suppliers. To mitigate the electrical energy demand used both for computing and for cooling, many scheduling and planning methods have been proposed. All of them can benefit from accurate predictions of the workload. In this paper we demonstrate how forecasting tools can remarkably increase the energy efficiency of a data center.
Why Hypotheses Informed by Observation Are Often Wrong: Results of Randomized Controlled Trials Challenge Chronic Disease Management Strategies Based on Epidemiological Evidence

For researchers and clinicians engaged in the important business of trying to prevent cardiovascular events in patients with type 2 diabetes, 2010 was a year of eyeopening surprises. The revelations began early with the March 2010 release of results from the blood pressure control component of the ACCORD randomized controlled trial (RCT). 2 Initiated in 2001 by the National Heart Lung and Blood Institute (NHLBI), ACCORD was an important landmark clinical trial for patients with type 2 diabetes and risk factors for cardiovascular disease; it represented the first large, experimental investigation of several key treatment guidelines that were based on sound epidemiological evidence but had never been subjected to the more rigorous test of an RCT. 3 ACCORD study subjects had type 2 diabetes, with a hemoglobin A1c level of at least 7.5%, and met cardiovascular risk criteria including (a) aged 40 years or older with cardiovascular disease or (b) aged 55 years or older with atherosclerosis, albuminuria, left ventricular hypertrophy, or at least 2 cardiovascular disease risk factors (obesity, smoking, dyslipidemia, or hypertension). 2 Of the 10,251 ACCORD study subjects, 4,733 met clinical criteria for inclusion in the blood pressure control component of the trial (systolic blood pressure [SBP] between 130 and 180 millimeters mercury [mmHg], taking 3 or fewer antihypertensive medications, and “the equivalent of a 24-hour protein excretion rate of less than 1.0 [grams]”). Patients were randomized to “intensive” therapy targeted to SBP less than 120 mmHg (n = 2,362) or “standard” therapy targeted to SBP less than 140 mmHg (n = 2,371). Patients were treated using “strategies that are currently available in clinical practice” and “drug classes … shown to result in a reduction in cardiovascular events among participants with diabetes. ” 2 At 1-year follow-up, mean SBPs were 119.3 (95% confidence interval [CI] = 118.9-119.7) mmHg and 133.5 (95% CI = 133.1-133.8) mmHg in the intensive- and standard-therapy groups, respectively, a difference that was “significant and sustained” throughout the study. However, in a mean 4.7 years of follow-up, the SBP differences did not translate into significant improvements in the primary endpoint outcome, a composite of nonfatal myocardial infarction (MI), nonfatal stroke, or cardiovascular death; annual rates were 1.87% in intensive therapy and 2.09% in standard therapy (hazard ratio [HR] = 0.88, 95% CI = 0.73-1.06, P = 0.20). Additionally, serious adverse events attributable to antihypertensive treatment, including hypotension, bradycardia or arrhythmia, and hyperkalemia, were more common in the intensive- than standard-therapy arm (3.3% vs. 1.3%, respectively, P < 0.001). 2
CT Findings of Axillary Tuberculosis Lymphadenitis: A Case Detected by Breast Cancer Screening Examination

We report the first description of CT findings of axillary tuberculous lymphadenitis confirmed by the pathological specimen. The breast cancer screening examination is one of the prime methods of detection of axillary tuberculous lymphadenitis. The most common site of axillary tuberculous lymphadenitis is the deep axilla. Screening mammography often fails to cover the whole axilla. The presence on the contrast-enhanced CT of unilateral multiple circumscribed dense nodes, some of which have large and dotted calcifications, might suggest tuberculous lymphadenitis in axillary region.
News from the future: A corpus linguistic analysis of future-oriented, unreal and counterfactual news discourse

This article presents a corpus linguistic analysis of the development in future-oriented political journalism in four Danish newspapers in the period 1997–2013 (N = 2954 full articles = 1,553,038 word tokens). Keyword analysis and concordance analysis are applied within a framework of grammatical-semantic theory of tense and modal verbs and semantic-pragmatic theory of time meaning, modality and speech acts. The results suggest, unexpectedly, that the newspapers – and news reports in particular – seem to have become less future-oriented in the period. At the same time, however, the articles – and particularly news commentary, in itself increasing – might have become slightly more speculative. Thus, the journalists themselves have become the main source of ‘guessing’, that is, predicting and speculating, with the keywords vil (will) and ville (would), including unreal and counterfactual speculations in the past tenses.
Control Design for Trajectory Tracking With Untimed Petri Nets

This technical note is about trajectory tracking for discrete event systems. The main contribution is to compute incrementally control sequences with minimal or near-minimal length based on a partial exploration of the Petri net (PN) reachability graph and inspired by the model predictive control approach. The method is suitable for bounded and unbounded PNs, for PNs with weighted arcs and with some uncontrollable transitions. Finally forbidden markings or regions of markings are easily avoided with the proposed approach that can be used for supervisory control issues.
Interference of Human Spermatozoal Motility by Live Staphylococcus aureus

The aim of this work was to investigate the effect of live Staphylococcus aureus commonly present in the cervix of females on sperm motility and agglutination in vitro. Highly motile samples of spermatozoa (40 x 10 6 /ml) from normozoospermic males were co-incubated for 4h with 10 7 cells/ml of live S. aureus. After 30 minutes, 1, 2 and 4h of incubation, sperm motility and agglutination was checked by light microscopic examination (X 400). From the onset, it was apparent that the live bacteria reduced the motility of spermatozoa. The promptness with which the decreased motility was observed to occur in the live S. aureus group was striking. After 30 minutes of mixing the ejaculate with the live bacteria, decrease in motility and clumping of the spermatozoa was noted. Interestingly, no agglutination and immobilization was observed in other experiments in which the bacteria were killed by heat, lysozyme or antibiotics and mixed with the ejaculate. Certainly, it seems evident that live S. aureus can significantly depress the motility and agglutinate human spermatozoa in vitro. The mechanism by which this alteration takes place is not obvious, however, detrimental effect on sperm motility by live staphylococci may be an as yet unrecognized component of fertility problems.