Miracle-dz/UniFAR-FTUs huggingface dataset:
Stanozolol in Chronic Urticaria: A Double Blind, Placebo Controlled Trial

H1‐type antihistamines drugs are mainstays in the management of chronic urticaria. For patients with refractory, chronic, idiopathic urticaria who have failed to benefit from conventional therapy, other safe therapeutic modalities are required. To evaluate the role of stanozolol as an adjunctive therapeutic agent with H1‐antihistamine in refractory chronic idiopathic urticaria, we conducted this study. Fifty‐eight patients with chronic refractory urticaria were enrolled in this trial and were randomly assigned to two groups (A and B). Patients in group A received 2 mg stanozolol twice daily along with cetrizine 10 mg daily. Patients in group B received cetrizine 10 mg daily and placebo tablets twice daily. The improvement was monitored by estimation of severity score. Of the 58 patients, 26 in group A and 24 in group B could be evaluated. At the end of 12 weeks, 17 patients in group A showed marked to complete resolution as compared to 7 patients in group B (chi‐square p<0.01). The intention to treat analysis p value was a found to be <0.007. There was a highly significant decrease in mean severity score at 12 weeks (p<0.001) in group A patients. The present study demonstrated that stanozolol is an effective and safe adjuvant therapy for treatment of chronic refractory urticaria.
INDIRECT DETECTION OF DECEPTION: LOOKING FOR CHANGE

In this study, we examined the effectiveness of using indirect methods to detect liars. College students viewed a video in which half of the people told some lies and half of the people were entirely truthful. Participants were either asked to detect the liars in the video or they were asked to identify people in the video whose behavior, mannerisms, or speech changed. Participants using the indirect lie detection method of looking for behavioral change were more accurate in their categorizations of liars and nonliars than were participants who were directly and explicitly looking for liars.
Post-Totalitarian Leadership: Elites in the German Federal Republic

A good deal has been heard in recent years concerning the “liberation” of peoples living under totalitarian rule, but the question of who are the men who succeed to the leadership of a state after the fall of its totalitarian rulers has received relatively little attention. Such observations as have been made on the subject, whether by political opponents of a totalitarian regime or by professional social scientists, have tended to follow implicitly—if not explicitly—the theory of alternating elites. There is assumed to be, on the one hand, a more or less homogeneous totalitarian elite, and, on the other, an actual or potential counter-elite, representing the political antithesis to the totalitarian elite. The stability of the rule of the former is said to vary inversely with the degree of organization of the latter. The totalitarian elite is variously identified with the holders of high positions in the totalitarian system, with the “responsible leaders,” with an entire ruling class, or simply with those individuals who are said to be influential in the determination of national policy. The counter-elite is identified with the active overt and covert opponents of the totalitarian elite—resistance leaders, the “vanguard of the proletariat,” prominent exiles, and “men on whose backs in concentration camps the lash has written the new gospel in blood and tears. ” Both elite and counter-elite are thus seen as directly, actively involved in the totalitarian system, either as its leaders or as its opponents. Revolution, in this schema, is identified with the destruction of the totalitarian elite and its replacement by the counter-elite. Or, conversely, the destruction of the totalitarian elite is an act of revolution and will result in the emergence of the counter-elite to power. It is an attractively simple thesis, and it warrants investigation.
Informational Frictions and Commodity Markets

This paper develops a model to analyze information aggregation in commodity markets. Through centralized trading, commodity prices aggregate dispersed information about the strength of the global economy among goods producers whose production has complementarity, and serve as price signals to guide producers' production decisions and commodity demand. Our analysis highlights important feedback effects of informational noise originating from supply shocks and futures market trading on commodity demand and spot prices, which are ignored by existing empirical studies and policy discussions.
Cervical phIGFBP‐1 in the evaluation of the risk of preterm delivery

Background. To evaluate the accuracy of the decidual phosphorylated isoform of insulin‐like growth factor binding protein‐1 in endocervical secretions to predict premature delivery in symptomatic and asymptomatic pregnant women. Methods. The study included 332 pregnant women: 109 symptomatic patients (study group) and 223 asymptomatic women (control group). For all women, qualitative and quantitative assessment of the decidual phosphorylated isoform of insulin‐like growth factor binding protein‐1 in endocervical secretions was carried out, but the quantitative assay was finally performed in 282 of 332. Student's test, the φ2 test, and Fisher's exact test were used as appropriate. Results. The phosphorylated insulin‐like growth factor binding protein‐1 qualitative test was positive in 35 of 301 women (11.6%) and 11 (31.4%) of them delivered before 37 weeks; in the remaining 266 women with a negative test, there were 11 (4.7%) premature deliveries (relative risk=5.8; 95% CI=3.3–10.3). The mean values of quantitative phosphorylated isoform of insulin‐like growth factor binding protein‐1 were 56.9 µg/l (95% CI=40.7–73.1) in cases of a positive qualitative test and 6.1 µg/l (95% CI=4.0–8.3; p = 0.0001) in women with a negative result. The sensitivity, specificity, positive predictive value, and negative predictive value for phosphorylated isoform of insulin‐like growth factor binding protein‐1 test in symptomatic patients were 69.2%, 90.5%, 50%, and 95.6% respectively, while in the asymptomatic patients they were 22.2%, 91.8%, 11.8%, and 96% respectively. Conclusions. The phosphorylated isoform of insulin‐like growth factor binding protein‐1 in cervical secretions is a potential specific marker for preterm delivery occurring before 37 weeks. This test may have an important role in the management of women presenting with symptoms suggestive of preterm labour.
Ongoing Gas Stripping in the Virgo Cluster Spiral Galaxy NGC 4522

The Virgo Cluster galaxy NGC 4522 is one of the best spiral candidates for intracluster medium–interstellar medium (ICM-ISM) stripping in action. Optical broadband and Hα images from the WIYN telescope of the highly inclined galaxy reveal a relatively undisturbed stellar disk and a peculiar distribution of Hα emission. Ten percent of the Hα emission arises from extraplanar H II regions which appear to lie within filamentary structures ≥3 kpc long above one side of the disk. The filaments emerge from the outer edge of a disk of bright Hα emission which is abruptly truncated beyond 0.35R25. Together the truncated Hα disk and extraplanar Hα filaments are reminiscent of a bow shock morphology, which strongly suggests that ISM of NGC 4522 is being stripped by the gas pressure of the ICM. The galaxy has a line-of-sight velocity of ≃1300 km s-1 with respect to the mean Virgo Cluster velocity and thus is expected to experience a strong interaction with the intracluster gas. The existence of H II regions apparently located above the disk plane suggests that star formation is occurring in the stripped gas, and that newly formed stars will enter the galaxy halo and/or intracluster space. The absence of H II regions in the disk beyond 0.35R25 and the existence of H II regions in the stripped gas suggest that even molecular gas has been effectively removed from the disk of the galaxy.
Implementing Synchronous Models on Loosely Time Triggered Architectures

Synchronous systems offer a clean semantics and an easy verification path at the expense of often inefficient implementations. Capturing design specifications as synchronous models and then implementing the specifications in a less restrictive platform allow to address a much larger design space. The key issue in this approach is maintaining semantic equivalence between the synchronous model and its implementation. We address this problem by showing how to map a synchronous model onto a loosely time-triggered architecture that is fairly straightforward to implement as it does not require global synchronization or blocking communication. We show how to maintain semantic equivalence between specification and implementation using an intermediate model (similar to a Kahn process network but with finite queues) that helps in defining the transformation. Performance of the semantic preserving implementation is studied for the general case as well as for a few special cases.
Key Influences of Cyberbullying for University Students

It is hard to imagine a world without mobile phones, PDAs, and wireless/Broadband access on PCs. With the prevalence of electronic communication tools, people (including students) are finding it harder to live without them. Not surprisingly, these electronic communication tools provide benefits that enrich students’ scholarly and social experiences. However, evidence also shows that the usage of electronic communication tools can result in negative behaviour such as cyberbullying. This study, building on prior research findings, develops a conceptual model to explore influences other than psychological factors, which lead to individuals displaying cyberbullying behaviour. We collected data from 134 university students, and our analysis indicates that 62% of the representative sample had experienced cyberbullying in the past year, and 40% of our respondents have conducted actions which can be constituted as cyberbullying behaviour in the past year. Our study also suggests that technology usage and social pressure are additional factors that influence a person to conduct cyberbullying related actions. Results from this study can provide directions to concerned parties, to develop strategies and policies to reduce this social problem to a minimum.
Inter-annual variability influences the eco-evolutionary dynamics of range-shifting

Understanding the eco-evolutionary dynamics of species under rapid climate change is vital for both accurate forecasting of biodiversity responses and for developing effective management strategies. Using an individual-based model we demonstrate that the presence and form (colour) of inter-annual variability in environmental conditions can impact the evolution of dispersal during range shifts. Under stable climate, temporal variability typically results in higher dispersal. However, at expanding margins, inter-annual variability actually inhibits the evolution of higher emigration propensities by disrupting the spatial sorting and natural selection processes. These results emphasize the need for future theoretical studies, as well as predictive modelling, to account for the potential impacts of inter-annual variability.
How to Bite Your Tongue Without Blowing Your Top: Implicit Evaluation of Emotion Regulation Predicts Affective Responding to Anger Provocation

People frequently have to control their emotions to function in life. However, mounting evidence suggests that deliberate emotion regulation often is costly. This presents a dilemma: Is it better to let emotions go or to pay the price of exerting costly control? In two studies, the authors explore whether emotion regulatory processes associated with implicit positive evaluation of emotion regulation might provide the benefits of successful emotion regulation without the costs. In Study 1, the authors introduce a measure of implicit evaluation of emotion regulation (ER-IAT). Study 2 examined whether this measure is associated with actual emotional responses to an anger provocation. It was found that greater ER-IAT scores were associated with lesser anger experience, fewer negative thoughts, lessened self-reported effortful emotion regulation, and an adaptive pattern of cardiovascular responding. These findings suggest that implicit positive evaluation of emotion regulation is associated with successful, automatic, and physiologically adaptive down-regulation of anger.
Comparison of Transient Heart Rate Reduction Associated with Acupuncture Stimulation in Supine and Sitting Subjects

We investigated the difference in transient heart rate reduction associated with brief acupuncture in 20 healthy subjects at rest in a supine and in a sitting position. After the subjects had been at rest for about 20 minutes, acupuncture needling using the sparrow-pecking method, in which the needle is moved vertically lifting and thrusting, was performed for one minute at the Shousanli point on the right forearm (LI10). The procedure was carried out with the subjects in a supine position and in a sitting position. The position for stimulation of each subject, either supine or sitting, was selected at random, and on different days. The results showed that the average heart rate reduction associated with stimulation in supine subjects was 3.6±0.19 (mean ± standard error {SE}) beats per minute (bpm), while that for sitting subjects was about 7.0±1.07 (mean ± SE) bpm, indicating that stimulation reduces heart rate to a greater degree in subjects who are sitting (p<0.05, Mann-Whitney test). These results would be consistent with a mechanism involving reduced sympathetic drive to the heart, as sympathetic nerve activity has more influence on the heart rate in the sitting than in the supine position.
Polygons and adhesion plaques and the disassembly and assembly of myofibrils in cardiac myocytes

Successive stages in the disassembly of myofibrils and the subsequent assembly of new myofibrils have been studied in cultures of dissociated chick cardiac myocytes. The myofibrils in trypsinized and dispersed myocytes are sequentially disassembled during the first 3 d of culture. They split longitudinally and then assemble into transitory polygons. Multiples of single sarcomeres, the cardiac polygons, are analogous to the transitory polygonal configurations assumed by stress fibers in spreading fibroblasts. They differ from their counterparts in fibroblasts in that they consist of muscle alpha-actinin vertices and muscle myosin heavy chain struts, rather than of the nonmuscle contractile protein isoforms of stress fiber polygons. EM sections reveal the vertices and struts in cardiac polygons to be typical Z and A bands. Most cardiac polygons are eliminated by day 5 of culture. Concurrent with the disassembly and elimination of the original myofibrils new myofibrils are rapidly assembled elsewhere in the same myocyte. Without exception both distal tips of each nascent myofibril terminate in adhesion plaques. The morphology and composition of the adhesion plaques capping each end of each myofibril are similar to those of the termini of stress fibers in fibroblasts. However, whereas the adhesion complexes involving stress fibers in fibroblasts consist of vinculin/nonmuscle alpha-actinin/beta- and gamma-actins, the analogous structures in myocytes involving myofibrils consist of vinculin/muscle alpha-actinin/alpha-actin. The addition of 1.7-2.0 microns sarcomeres to the distal tips of an elongating myofibril, irrespective of whether the myofibril consists of 1, 10, or several hundred tandem sarcomeres, occurs while the myofibril appears to remain linked to its respective adhesion plaques. The adhesion plaques in vitro are the equivalent of the in vivo intercalated discs, both in terms of their molecular composition and with respect to their functioning as initiating sites for the assembly of new sarcomeres. How 1.7-2.0 microns nascent sarcomeres can be added distally during elongation while the tips of the myofibrils remain inserted into submembranous adhesion plaques is unknown.
Sikap Remaja terhadap Keperawanan dan Perilaku Seksual dalam Berpacaran

Abstrak Laporan Survei Demografi dan Kesehatan Indonesia (SDKI) tahun 2007 dan 2012 menunjukkan terjadinya penurunan jumlah remaja yang memiliki sikap positif terhadap pentingnya mempertahankan keperawanan bagi seorang perempuan. Dari laporan yang sama juga diketahui adanya peningkatan perilaku seksual remaja dalam hal berpegangan tangan, berciuman bibir, petting, dan melakukan hubungan seksual. Penelitian ini bertujuan untuk membuktikan adanya hubungan antara sikap remaja terhadap keperawanan dengan perilaku seksual dalam berpacaran dengan melibatkan usia, jenis kelamin, pendidikan, tempat tinggal, usia pertama kali pacaran, pengetahuan, dan pengaruh teman sebaya sebagai variabel perancu. Penelitian ini merupakan penelitian kuantitatif dengan rancangan potong lintang menggunakan model faktor risiko dari data SDKI 2012 yang dianalisis secara univariat, bivariat, dan multivariat dengan complex samples. Populasi penelitian adalah remaja berusia 15 - 24 tahun, belum menikah, pernah atau sedang berpacaran saat survei dilakukan. Sampel berjumlah 13.013 yang terdiri dari 7.329 laki-laki dan 5.684 perempuan. Hasil menunjukkan 1,1% remaja tidak setuju terhadap pentingnya menjaga keperawanan dan 25,2% remaja memiliki perilaku seksual berisiko. Terdapat hubungan antara sikap, usia, jenis kelamin, pengetahuan, dan pengaruh teman sebaya dengan perilaku seksual. Tidak terdapat interaksi antara sikap dengan usia, jenis kelamin, pendidikan, pengetahuan, dan pengaruh teman sebaya. Variabel pengaruh teman sebaya merupakan variabel perancu yang memengaruhi hubungan antara sikap dengan perilaku seksual. Abstract Indonesia Demographic and Health Survey (IDHS) reports in 2007 and 2012 show a declining number of teenagers who had positive attitude to the importance of maintaining virginity for a woman. The same report also shows an increase of teenage sexual behavior in terms of holding hands, kissing, petting and intercourse. This study aimed to prove any relation of teenage attitudes toward virginity with sexual behavior in dating that involved age, sex, education, domicile, age of first dating, knowledge and peers’influence as confounding variables. This study was quantitative with cross-sectional design using risk factor model based on IDHS 2012 data as analyzed in univariate, bivariate and multivariate with complex samples. Population of study was 15 – 24 year-old teenagers, unmarried, ever or being in a relationship when the survey was conducted. The amount of sample was 13,013 consisting of 7,329 men and 5,684 women. Results showed 1.1% of teenagers disagreed of the importance of maintaining virginity and 25.2% had risky sexual behavior. There was a relation of attitude, age, sex, knowledge and peers’ influence with sexual behavior. Then no interaction found between attitudes with age, sex, education, knowledge and peers’influence. Peers’ influence variable is confounding variable affecting the relation between attitudes and sexual behavior.
The SR-BI Partner PDZK1 Facilitates Hepatitis C Virus Entry

Entry of hepatitis C virus (HCV) into hepatocytes is a multi-step process that involves a number of different host cell factors. Following initial engagement with glycosaminoglycans and the low-density lipoprotein receptor, it is thought that HCV entry proceeds via interactions with the tetraspanin CD81, scavenger receptor class B type I (SR-BI), and the tight-junction proteins claudin-1 (CLDN1) and occludin (OCLN), culminating in clathrin-dependent endocytosis of HCV particles and their pH-dependent fusion with endosomal membranes. Physiologically, SR-BI is the major receptor for high-density lipoproteins (HDL) in the liver, where its expression is primarily controlled at the post-transcriptional level by its interaction with the scaffold protein PDZK1. However, the importance of interaction with PDZK1 to the involvement of SR-BI in HCV entry is unclear. Here we demonstrate that stable shRNA-knockdown of PDZK1 expression in human hepatoma cells significantly reduces their susceptibility to HCV infection, and that this effect can be reversed by overexpression of full length PDZK1 but not the first PDZ domain of PDZK1 alone. Furthermore, we found that overexpression of a green fluorescent protein chimera of the cytoplasmic carboxy-terminus of SR-BI (amino acids 479–509) in Huh-7 cells resulted in its interaction with PDZK1 and a reduced susceptibility to HCV infection. In contrast a similar chimera lacking the final amino acid of SR-BI (amino acids 479–508) failed to interact with PDZK1 and did not inhibit HCV infection. Taken together these results indicate an indirect involvement of PDZK1 in HCV entry via its ability to interact with SR-BI and enhance its activity as an HCV entry factor.
What is Trust? A Multidisciplinary Review, Critique, and Synthesis

Despite decades of interdisciplinary research on trust, the literature remains fragmented and balkanized with little consensus regarding its origins. This review documents how this came to be and attempts to offer a solution. Specifically, it evaluates issues of conceptualization found in the trust literature. I recommend that we move away from varieties of trust — multidimensional conceptualizations of trust — and toward a single trust concept built around four basic elements: actor A’s beliefs, actor B’s trustworthiness, the matter(s) at hand, and unknown outcomes. I finish the article by proposing a synthetic structural-cognitive theoretical framework for investigating the causes and consequences of trust in everyday life.
Reliability and Validity of the Korean Version VISA-P Questionnaire for Patellar Tendinopathy in Adolescent Elite Volleyball Athletes

Objective To translate the English Victorian Institute of Sport Assessment for patellar tendinopathy (VISA-P) questionnaire into a Korean version and to determine the reliability and validity of the Korean version. Methods The English VISA-P questionnaire was translated into Korean according to the internationally recommended guidelines. Then, 28 adolescent elite volleyball athletes (average age, 16 years; range, 14 to 19 years) were asked to complete the questionnaire three times (before examination, after examination, and 1 week later) for reliability. They were evaluated through a physical examination and ultrasonography to diagnosis patellar tendinopathy. Results The internal consistency of the VISA-P questionnaire by Cronbach's alpha was 0.80 for the first, 0.78 for the second, and 0.79 for the third assessment. The intraclass correlation coefficient (ICC) between the first and second assessments was 0.97. The ICC between the second and third assessments was 0.96. The mean VISA-P scores were 67.6±15.7 for the patellar tendinopathy group (n=23) and 92.6±8.6 for the normal group (n=5). There were significantly lower VISA-P scores in the patellar tendinopathy group compared to the normal group. Conclusion The translated Korean version VISA-P questionnaire has good internal consistency, test-retest reliability and validity. In addition, this study indicated that most adolescent elite volleyball athletes had patellar tendon problems. Therefore, the Korean version VISA-P is a useful self-administered outcome score of athletes with patellar tendinopathy.