Miracle-dz/UniFAR-FTUs huggingface dataset:
Adult Attachment Styles, Perceived Social Support and Coping Strategies

The relations between adult attachment styles, perceived social support and the use of various coping strategies was examined in a sample of young adults (N = 81). Participants completed measures of adult attachment style, perceived social support from friends and family, and a modified version of the Ways of Coping scale. In addition, participants rated the coping strategies they would most likely use in response to a series of hypothetical vignettes describing social- and achievement-related stressors. Results indicated that secure individuals perceived more available support from friends and family, and sought more social support in response to stress. Although preoccupied adults also sought social support in response to stress, they also tended to use escape/avoidance strategies. Dismissing and fearful individuals were much less likely to seek social support, and were more likely to distance themselves in some contexts. Finally, regression analyses indicated that the link between secure attachment and support-seeking as a coping strategy was mediated, in part, by the perception that support is available from friends and family.
Quantitative Proteomics Reveals Regulation of Dynamic Components within TATA-binding Protein (TBP) Transcription Complexes*S

Affinity purification in combination with isotope labeling of proteins has proven to be a powerful method to discriminate specific from nonspecific interactors. However, in the standard SILAC (stable isotope labeling by amino acids in cell culture) approach dynamic components may easily be assigned as nonspecific. We compared two affinity purification protocols, which in combination revealed information on the dynamics of protein complexes. We focused on the central component in eukaryotic transcription, the human TATA-binding protein, which is involved in different complexes. All known TATA-binding protein-associated factors (TAFs) were detected as specific interactors. Interestingly one of them, BTAF1, exchanged significantly in cell extracts during the affinity purification. The other TAFs did not display this behavior. Cell cycle synchronization showed that BTAF1 exchange was regulated during mitosis. The combination of the two affinity purification protocols allows a quantitative approach to identify transient components in any protein complex.
The Intersection of Trauma, Racism, and Cultural Competence in Effective Work with Aboriginal People: Waiting for Trust

Abstract The consistent failure of initiatives aimed at addressing discrepancies between Australia's Aboriginal and non Aboriginal citizens point to a need to address responses to Aboriginal people by mainstream service providers. This practice paper draws on the experience of Aboriginal and non Aboriginal practitioners in the trauma field to consider the limitations and potential of “cultural competence” as a construct for working with Aboriginal and Torres Strait Islander peoples. Key limitations are the lack of accounting for the trauma and ongoing racism experienced by Aboriginal people, which result in isolation of communities, protection of abusers, and under-use of mainstream services by Aboriginal people. When trauma and racism are addressed, successful and respectful engagement with Aboriginal individuals and communities becomes possible and the potential of cultural competency initiatives can be realised. A three-step process for achieving this at the personal, practice, and agency levels, which has been developed in a collaboration by Aboriginal and non Aboriginal practitioners, is outlined.
JAK-STAT signaling in stem cells and their niches in Drosophila

JAK-STAT signaling is a highly conserved regulator of stem cells and their niches. Aberrant activation in hematopoietic stem cells is the underlying cause of a majority of myeloproliferative diseases. This review will focus on the roles of JAK-STAT activity in three different adult stem cell systems in Drosophila. Tightly controlled levels of JAK-STAT signaling are required for stem cell maintenance and self-renewal, as hyperactivation of the pathway is associated with stem cell overproliferation. JAK-STAT activity is further essential for anchoring the stem cells in their respective niches by regulating different adhesion molecules.
Examining couple agreement about work‐family conflict

– This study aims to explore the nature of couple agreement about work‐family conflict, adding to previous research by explicitly testing the extent to which couples agree when rating work interference with family (WIF) and the influence of this agreement on other outcomes. , – In total, 224 dual‐earner couples were surveyed to assess their own WIF, as well as what they believed to be their partner's level of WIF. Participants also completed questions regarding their organizational commitment. , – Couples agreed when rating their own and their partners' WIF more than they disagreed. As predicted, couples agreed more when rating the female partner's WIF as compared to the male partner's WIF. Finally, couple agreement about WIF moderated the relationship between female WIF and her continuance organizational commitment such that the relationship between the female partner's WIF and her level of continuance commitment was stronger when agreement about her experienced WIF was low. , – This was a convenience sample, and therefore caution should be used when generalizing to a broader population. Second, the research design was cross‐sectional, prohibiting causal inferences and conclusions about couple agreement over time. , – Organizations should consider the perceptions and attitudes of both employees and their partners, as both have implications for work attitudes. Organizations might benefit from considering ways in which they can involve and engage employees' spouses and partners, and could offer flexible schedules as a way to reduce employee work‐to‐family conflict and enhance both employee and partner attitudes toward the organization. , – This paper contributes to the literature by exploring both self and partner perceptions of work‐family conflict and examining couple agreement about this conflict.
BEYOND SIMPLE EXPOSURE

This study adopts a broad approach to problems associated with confusion in the literature on media orientations and political processes. Three different dependent variables representing cognition, attitude and behavior are examined in relation to multiple measures of media dependence: time spent, reliance, exposure to content, level of attention and gratifications sought. Results suggest complex relationships between media use and the dependent variables and again confirm an integrative role for television that is often hidden in analyses based on simple exposure time.
Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia

Thalassemia is the world’s most common form of inherited anemia, and in economically undeveloped countries still accounts for tens of thousands of premature deaths every year. [1][1] The accumulation of free excess α-globin chains in red blood cells and their precursors, as a result of the
[The prevalence of low back pain in hospital staff and its relationship with chronic fatigue syndrome and occupational factors].

OBJECTIVES This study aimed to investigate the occurrence of low back pain in hospital employees during the previous year and its correlation with demographic data, occupational factors and chronic fatigue syndrome. METHODS All participants provided information on their socio-demographic background, occupational characteristics, their experience of low back pain during the previous year, and chronic fatigue syndrome. RESULTS The study included 365 volunteers (221 male and 144 female). The mean age was 33.1 ± 7.2. Of the 365 participants, 218 (59.7%) had experienced low back pain in the last year. No statistically significant difference was detected in age, height, weight, level of education, smoking habits, occupation, professional working hours, shift work or levels of income between the groups with and without low back pain. Low back pain was more frequent (p<0.05) in male workers. Chronic fatigue syndrome was statistically significant in the group suffering from low back pain (p<0.05), of whom 21.5% had chronic fatigue syndrome. We detected a statistically significant relationship (p<0.05) between chronic fatigue syndrome, occupational duration and shift work. CONCLUSION To the best of our knowledge, this is the first to show the relationship between low back pain and chronic fatigue syndrome in hospital employees. Shift work and length of time in occupation are risk factors for chronic fatigue syndrome.
Tracing discourses of health and the body: exploring pre-service primary teachers' constructions of ‘healthy’ bodies

Contemporary notions of childhood overweight and obesity have become increasingly influential in curriculum and pedagogy in school-based Health and Physical Education (HPE). Teachers' delivery of HPE subject matter and related school practices are likely to have a considerable impact on the attitudes and beliefs of the children they teach, particularly in the primary school. It thus becomes important to consider the ways of thinking about and doing health (discourse positions on health) that teachers bring to their teaching of HPE. This paper examines pre-service teachers' positions in relation to the health discourses to better understand what teachers, in this case beginning teachers, bring to their teaching of HPE and interactions with children in primary schools. It draws on a Foucauldian approach to discourse analysis to analyse pre-service teachers' qualitative survey and interview responses to questions about meanings of health. Three key positions emerged, signifying Agreement, Disagreement and Negotiated positions in relation to the dominant discourses of health and the body.
‘Sham Surgery’ Control Groups: Ethics and Context

The use of placebo controls in surgical research, or ‘sham surgery’ as it sometimes described, raises a number of ethical issues. Despite such issues, sham surgery is presently being employed, albeit very rarely, in surgical research. In this paper, the ethical implications of such control groups are discussed in the context of research into various conditions, including Parkinson's Disease and arthritis. Conflicting ethical considerations include: i) patients' best interests in relation to the harms and risks involved; ii) the need for more rigorous methods in surgical research, and iii) the question of patient autonomy. Contextual features which may influence the ethical acceptability of a specific sham-controlled surgical trial are discussed.
A Review of Strategic Process Research

This article reviews research on the process of strategic management reported over the last six years in seven leading journals. Nine " 'streams" of work are identified and critiqued. The field is described as giving continuing attention to the possibilities and problems of strategic planning and decision making, but also moving into new areas of research-especially the problem of how the attention of decision makers is directed toward specific agendas for action. We recommend more studies that simultaneously consider strategy formulation and implementation and more studies that attempt to integrate methods and concerns across the various areas of process research. Finally, we recommend that future research give simultaneous attention to the content as well as the process of strategy.
Open Call-by-Value (Extended Version)

The elegant theory of the call-by-value lambda-calculus relies on weak evaluation and closed terms, that are natural hypotheses in the study of programming languages. To model proof assistants, however, strong evaluation and open terms are required, and it is well known that the operational semantics of call-by-value becomes problematic in this case. Here we study the intermediate setting -- that we call Open Call-by-Value -- of weak evaluation with open terms, on top of which Gregoire and Leroy designed the abstract machine of Coq. Various calculi for Open Call-by-Value already exist, each one with its pros and cons. This paper presents a detailed comparative study of the operational semantics of four of them, coming from different areas such as the study of abstract machines, denotational semantics, linear logic proof nets, and sequent calculus. We show that these calculi are all equivalent from a termination point of view, justifying the slogan Open Call-by-Value.
Estereotipos sobre la vejez y su relación con la formación en gerontología: un estudio intergeneracional.

The aim of this paper is to determine the level of agreement with a series of stereotypes present in our society. These stereotypes are related to sexuality, personality, and cognitive aspects in old people. A sample of 806 people was divided into four groups: youths and older people who had some gerontology education and youths and older people without gerontology education. The analysis carried out shows that gerontology education is extremely relevant to avoid erroneous beliefs about old people. The results reveal the low degree of agreement with the statements: Impotence is usually psychological, but in old men, it is due to age; Old people do not benefit much from education due to their cognitive deficits; Intelligence peaks around the age of 30 and then declines gradually; Sooner or later, old people become senile; Senile people cannot be helped by psychotherapy; Personality is relatively stable in adulthood; and Menopause causes nervous breakdowns.
Direct magnetic resonance detection of myelin and prospects for quantitative imaging of myelin density

Magnetic resonance imaging has previously demonstrated its potential for indirectly mapping myelin density, either by relaxometric detection of myelin water or magnetization transfer. Here, we investigated whether myelin can be detected and possibly quantified directly. We identified the spectrum of myelin in the spinal cord in situ as well as in myelin lipids extracted via a sucrose gradient method, and investigated its spectral properties. High-resolution solution NMR spectroscopy showed the extract composition to be in agreement with myelin’s known chemical make-up. The 400-MHz 1H spectrum of the myelin extract, at 20 °C (room temperature) and 37 °C, consists of a narrow water resonance superimposed on a broad envelope shifted ∼3.5 ppm upfield, suggestive of long-chain methylene protons. Superimposed on this signal are narrow components resulting from functional groups matching the chemical shifts of the constituents making up myelin lipids. The spectrum could be modeled as a sum of super-Lorentzians with a T2* distribution covering a wide range of values (0.008–26 ms). Overall, there was a high degree of similarity between the spectral properties of extracted myelin lipids and those found in neural tissue. The normalized difference spectrum had the hallmarks of membrane proteins, not present in the myelin extract. Using 3D radially ramp-sampled proton MRI, with a combination of adiabatic inversion and echo subtraction, the feasibility of direct myelin imaging in situ is demonstrated. Last, the integrated signal from myelin suspensions is shown, both spectroscopically and by imaging, to scale with concentration, suggesting the potential for quantitative determination of myelin density.
AUTONOMY, SOCIAL IDENTITIES, AND ALIENATION

“Community” and autonomy are both considered to be positive values; the problem is that they conflict. A communitarian theory of alienation and dealienation seeks to make societal adjustments that are suggested by a particular theory of human nature, namely one according to which humans are innately social and require social identities in order to flourish. The remedies are likely to be socially (although not necessarily politically) conservative, with some analogies to the social conservatism of traditional (tribal) societies. On this theory the causes of alienation are what causes a lack of any sense of what one is, or a sense of social exclusion, or the absence of a sense of possession toward one's community or work place.
Automated Genome-Wide Visual Profiling of Cellular Proteins Involved in HIV Infection

Recent genome-wide RNAi screens have identified >842 human genes that affect the human immunodeficiency virus (HIV) cycle. The list of genes implicated in infection differs between screens, and there is minimal overlap. A reason for this variance is the interdependence of HIV infection and host cell function, producing a multitude of indirect or pleiotropic cellular effects affecting the viral infection during RNAi screening. To overcome this, the authors devised a 15-dimensional phenotypic profile to define the viral infection block induced by CD4 silencing in HeLa cells. They demonstrate that this phenotypic profile excludes nonspecific, RNAi-based side effects and viral replication defects mediated by silencing of housekeeping genes. To achieve statistical robustness, the authors used automatically annotated RNAi arrays for seven independent genome-wide RNAi screens. This identified 56 host genes, which reliably reproduced CD4-like phenotypes upon HIV infection. The factors include 11 known HIV interactors and 45 factors previously not associated with HIV infection. As proof of concept, the authors confirmed that silencing of PAK1, Ku70, and RNAseH2A impaired HIV replication in Jurkat cells. In summary, multidimensional, visual profiling can identify genes required for HIV infection.
Differential association of tumour necrosis factor-alpha single nucleotide polymorphism (-308) with tuberculosis and bronchial asthma.

BACKGROUND Tumour necrosis factor (TNF)-alpha is a pleiotropic, pro-inflammatory cytokine of 17 kDa, whose gene is localized on the short arm of chromosome 6. It has a G-308A polymorphism in the promoter region, which is known to be associated with its differential production; the A allele being the high producer. The circulating level of TNF-alpha is under genetic control and implicated in the pathophysiology of asthma and tuberculosis. Since raised levels of TNF-alpha have been found in asthma and tuberculosis, we looked for the association of TNF-alpha G-308A polymorphism in patients with these diseases. METHODS A total of 300 blood samples from patients (155 with asthma, 145 tuberculosis) and 211 normal healthy controls were collected. The G-308A polymorphism was studied using amplification refractory mutation system analysis. RESULTS The distribution of G/A alleles in the two patient groups when compared with normal controls revealed a statistically significant association with asthma (p = 0.016) but not with tuberculosis (p = 0.178). CONCLUSION The data support the common variant common disease hypothesis, which emphasizes that common genetic variations may participate as critical players in inciting common diseases.
Chronic Disease Management for Depression in US Medical Practices: Results From the Health Tracking Physician Survey

BackgroundChronic care model (CCM) envisages a multicomponent systematic remodeling of ambulatory care to improve chronic diseases management. Application of CCM in primary care management of depression has traditionally lagged behind the application of this model in management of other common chronic illnesses. In past research, the use of CCM has been operationalized by measuring the use of evidence-based organized care management processes (CMPs). ObjectivesTo compare the use of CMPs in treatment of depression with the use of these processes in treatment of diabetes and asthma and to examine practice-level correlates of this use. Study DesignUsing data from the 2008 Health Tracking Physician Survey, a nationally representative sample of physicians in the United States, we compared the use of 5 different CMPs: written guidelines in English and other languages for self-management, availability of staff to educate patients about self-management, availability of nurse care managers for care coordination, and group meetings of patients with staff. We further examined the association of practice-level characteristics with the use of the 5 CMPs for management of depression. ResultsCMPs were more commonly used for management of diabetes and asthma than for depression. The use of CMPs for depression was more common in health maintenance organizations [adjusted odds ratios (AOR) ranging from 2.45 to 5.98 for different CMPs], in practices that provided physicians with feedback regarding quality of care to patients (AOR range, 1.42 to 1.69), and in practices with greater use of clinical information technology (AOR range, 1.06 to 1.11). ConclusionThe application of CMPs in management of depression continues to lag behind other common chronic conditions. Feedbacks on quality of care and expanded use of information technology may improve application of CMPs for depression care in general medical settings.
Large System Analysis for Amplify & Forward SIMO Multiple Access Channel with Ill-conditioned Second Hop

Relaying has been extensively studied during the last decades and has found numerous applications in wireless communications. The simplest relaying method, namely amplify and forward, has shown potential in MIMO multiple access systems, when Gaussian fading channels are assumed for both hops. However, in some cases ill conditioned channels may appear on the second hop. For example, this impairment could affect cooperative BS systems with microwave link backhauling, which involve strong line of sight channels with insufficient scattering. In this paper, we consider a large system analysis of such as model focusing on both optimal joint decoding and joint MMSE filtering receivers. Analytical methods based on free probability are presented for calculating the ergodic throughput, the MMSE error and the average SINR. Furthermore, the performance degradation of the system throughput is evaluated considering second hop impairments such as ill-conditioning and rank deficiency, while high- and low-SNR limits are calculated for the considered performance metrics. Finally, the cooperative BS system is compared to a conventional channel resource division strategy and suitable operating points are proposed.
Facing the Nonresponse Challenge

This article provides a brief overview of key trends in the survey research to address the nonresponse challenge. Noteworthy are efforts to develop new quality measures and to combine several data sources to enhance either the data collection process or the quality of resulting survey estimates. Mixtures of survey data collection modes and less burdensome survey designs are additional steps taken by survey researchers to address nonresponse.
An Extension Result for Continuous Valuations

It is shown, by a simple and direct proof, that if a bounded valuation on a monotone convergence space is the supremum of a directed family of simple valuations, then it has a unique extension to a Borel measure. In particular, this holds for any directed complete partial order with the Scott topology. It follows that every bounded and continuous valuation on a continuous directed complete partial order can be extended uniquely to a Borel measure. The last result also holds for σ‐finite valuations, but fails for directed complete partial orders in general.