Miracle-dz/UniFAR-FTUs huggingface dataset:
Routing Protocols in Vehicular Ad Hoc Networks: A Survey and Future Perspectives

Vehicular Ad hoc Network (VANET), a subclass of mobile ad hoc networks (MANETs), is a promising approach for the intelligent transportation system (ITS). The design of routing protocols in VANETs is important and necessary issue for support the smart ITS. The key difference of VANET and MANET is the special mobility pattern and rapidly changeable topology. It is not effectively applied the existing routing protocols of MANETs into VANETs. In this investigation, we mainly survey new routing results in VANET. We introduce unicast protocol, multicast protocol, geocast protocol, mobicast protocol, and broadcast protocol. It is observed that carry-and-forward is the new and key consideration for designing all routing protocols in VANETs. With the consideration of multi-hop forwarding and carry-and-forward techniques, min-delay and delay-bounded routing protocols for VANETs are discussed in VANETs. Besides, the temporary network fragmentation problem and the broadcast storm problem are further considered for designing routing protocols in VANETs. The temporary network fragmentation problem caused by rapidly changeable topology influence on the performance of data transmissions. The broadcast storm problem seriously affects the successful rate of message delivery in VANETs. The key challenge is to overcome these problems to provide routing protocols with the low communication delay, the low communication overhead, and the low time complexity. The challenges and perspectives of routing protocols for VANETs are finally discussed.
SOFTWARE ENGINEERING PROCESS AND ITS IMPROVEMENT IN THE ACADEMY

Changes in software technology and models for software development require commensurate change in the education of software developers. One way of teaching software engineering is to organize a course around a project similar to a real industrial project. The educational community itself is increasingly moving from lecture-format courses to team projects, problem-solving, direct involvement with actual development, and other formats that require students to exercise the ideas they are learning. In this paper we investigate the software engineering process improvement at Kaunas University of Technology to let students experience the realistic software engineering problems and environments during their software engineering education. Organizing the software engineering process we implemented some key practices of repeatable level of Capability Maturity Model.
Visualization of the Opening Process of a Discharge Reed Valve in the Presence of Oil

Oil in circulation in refrigeration systems generally degrades their thermodynamic and reliability performance. The vast majority of compressors used in the residential, automotive and light commercial air conditioning and refrigeration use pressure actuated reeds as the discharge valves. These valves are the gateway for the oil to leave the compressor to the rest of the system. This work is focused on the breakup process of the film that is formed between a reed valve and its seat. Emphasis is given on visualization of the breakup pattern and determination of the critical valve lift and velocity at which the film breaks during typical compressor operation. Preliminary experiments were carried out outside of the compressor environment, using a typical valve plate from a reciprocating compressor for household refrigerators. Observations of the breakup pattern show that the liquid film does not remain continuous until breakup into ligaments and droplets. In fact the stretched liquid film is first broken up into equally spaced liquid columns and then by means of the drag force promoted by the vapor flow due to the pressure difference it is blown away from the valve edge and starts the atomization process into a fine mist. Additional experiments were also carried out with two different oil viscosities (32cSt & 120cSt), and four different operating frequencies ranging from 30Hz-60Hz in a scroll type compressor operating under typical residential air conditioning conditions. High speed videos were utilized to quantify the droplet cloud velocities, and also valve critical lift before oil is ejected from the gap between valve and seat. The droplet cloud velocity is compared to a calculation using a compressor thermodynamic model to estimate the vapor velocity at the discharge valve.
Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)

Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large and diverse family of natural products. They possess interesting biological properties such as antibiotic or anticancer activities, making them attractive for therapeutic applications. In contrast to polyketides and non-ribosomal peptides, RiPPs derive from ribosomal peptides and are post-translationally modified by diverse enzyme families. Among them, the emerging superfamily of radical SAM enzymes has been shown to play a major role. These enzymes catalyze the formation of a wide range of post-translational modifications some of them having no counterparts in living systems or synthetic chemistry. The investigation of radical SAM enzymes has not only illuminated unprecedented strategies used by living systems to tailor peptides into complex natural products but has also allowed to uncover novel RiPP families. In this review, we summarize the current knowledge on radical SAM enzymes catalyzing RiPP post-translational modifications and discuss their mechanisms and growing importance notably in the context of the human microbiota.
A statistical mechanical analysis of postural sway using non-Gaussian FARIMA stochastic models

In this paper, postural sway is modeled using a fractional autoregressive integrated moving average (FARIMA) family of models: the center-of-pressure (COP) motion is viewed in terms of a self-similar, anti-persistent random-walk process, obtained by fractionally summating non-Gaussian random variables, whose correlation structure for small time lags is shaped by a linear time-invariant low-pass filter. The model parameters are: the strength of the stochastic driving, e.g., the root mean square (rms) value of the time-difference COP motion; the DC gain, damping ratio and natural frequency of the filter; the Hurst exponent, which measures the random-walk antipersistence magnitude. In the proposed modeling procedure, a graphical estimator for determining the Hurst exponent is cascaded to a method for matching autoregressive (AR) models to fractionally difference COP motion via higher order cumulants. The effect of the presence or absence of vision on the model parameter values is discussed with regard to data from experiments on healthy young adults.
Shortest Path Discovery Problems: A Framework, Algorithms and Experimental Results

In this paper we introduce and study Shortest Path Discovery (SPD) problems, a generalization of shortest path problems: In SPD one is given a directed edge-weighted graph and the task is to find a the shortest path for fixed source and target nodes such that initially the edge-weights are unknown, but they can be queried. Querying the cost of an edge is expensive and hence the goal is to minimize the total number of edge cost queries executed. In this article we characterize some common properties of sound SPD algorithms, propose a particular algorithm that is shown to be sound and effective. Experimental results on real-world OCR task demonstrate the usefulness of the approach whereas the proposed algorithm is shown to yield a substantial speed-up of the recognition process.
A $W$-band Injection-Locked Frequency Divider Using GaAs pHEMTs and Cascode Circuit Topology

This study presents a W-band injection-locked frequency divider (ILFD) with a wide locking range characteristic by using 0.15 mum GaAs pHEMT techniques. Based on the cascode circuit topology, the oscillation and the injection parts can be designed individually without the trade-off between the input matching and the oscillation condition. Including with a characteristic of the active capacitance in this ILFD, a free-running oscillation frequency about 50 GHz was obtained with a frequency tuning function, in which the tuning range was about 1.2 GHz (50.5-49.3 GHz). By injecting a signal of around 100 GHz into this ILFD, the maximum locking range was measured up to 400 MHz, while the injected power was set to -5 dBm under a 3 V supply with a power consumption of 21 mW in the ILFD core.
DTFC-SVM motion-sensorless control of a PM-assisted reluctance synchronous machine as starter-alternator for hybrid electric vehicles

Permanent magnet-assisted reluctance synchronous machine (PM-RSM) starter alternator systems are credited with good performance for wide speed range in hybrid electric vehicles. This paper proposes a motion-sensorless motor/generator control of PM-RSM from zero speed up to maximum speed, using direct torque and flux control with space vector modulation. A quasioptimal stator flux reference with a flux versus torque functional is proposed. A stator flux observer in wide speed range uses combined voltage-current models for low speeds, and only the voltage model for medium to high speeds, both in proportional-integral closed loop. A novel rotor speed and position observer with a fusion strategy employs signal injection and only one D-module vector filter in stator reference for low speed, combined with a speed observer from the stator flux vector estimation-for medium-high speed. The proposed system is introduced piece by piece and then implemented on a dSpace 1103 control board with a 350-A metal-oxide-semiconductor field-effect transistor-pulse-width modulation converter connected to a 42-Vdc, 55-Ah battery, and a 140-Nm peak torque PM-RSM. Extensive experimental results from very low speed to high speed, regarding observers and drive responses, including artificial loading (motoring and generating), seem very encouraging for future starter-alternator systems
Genistein Ameliorates Cyclophosphamide - Induced Hepatotoxicity by Modulation of Oxidative Stress and Inflammatory Mediators

AIM: The present study investigated the protective effect of the phytoestrogen, genistein (GEN), against (CP)-induced acute hepatotoxicity in rats. MATERIAL AND METHODS: Male adult rats were randomly assigned into five groups. Normal control group received the vehicles; CP group received a single dose of CP (200 mg/kg, i.p). The other three groups received subcutaneous GEN at doses of 0.5, 1 and 2 mg/kg/day, respectively, for 15 consecutive days prior CP injection. Sera and liver tissues were collected forty-eight hours after CP injection for assessment of liver function enzymes (ALT and AST) in rat sera, the hepatic oxidative/nitrosative biomarkers (GSH, MDA and NOx), hepatic interleukin-1β, and myeloperoxidase activity. Immunohistochemistry of cyclooxygenase-2 and histopathological examination of liver tissues were also conducted. RESULTS: The CP-induced acute liver damage was evidenced by elevated serum ALT and AST accompanied by increased hepatic oxidative stress and inflammatory biomarkers. Immunohistochemical outcomes revealed hepatic cyclooxygenase-2 expression in CP group with distortion of liver architecture. GEN-pretreatment significantly ameliorated the deterioration of liver function and exerted significant anti-oxidant and anti-inflammatory activity with a marked decline in hepatic cyclooxygenase-2 expression in a dose dependent-manner. CONCLUSION: The present study demonstrated that the antioxidant and anti-inflammatory activities of GEN might contribute to its protective effects against CP-induced liver damage.
Multiple White Matter Volume Reductions in Patients with Panic Disorder: Relationships between Orbitofrontal Gyrus Volume and Symptom Severity and Social Dysfunction

Numerous brain regions are believed to be involved in the neuropathology of panic disorder (PD) including fronto-limbic regions, thalamus, brain stem, and cerebellum. However, while several previous studies have demonstrated volumetric gray matter reductions in these brain regions, there have been no studies evaluating volumetric white matter changes in the fiber bundles connecting these regions. In addition, although patients with PD typically exhibit social, interpersonal and occupational dysfunction, the neuropathologies underlying these dysfunctions remain unclear. A voxel-based morphometry study was conducted to evaluate differences in regional white matter volume between 40 patients with PD and 40 healthy control subjects (HC). Correlation analyses were performed between the regional white matter volumes and patients' scores on the Panic Disorder Severity Scale (PDSS) and the Global Assessment of Functioning (GAF). Patients with PD demonstrated significant volumetric reductions in widespread white matter regions including fronto-limbic, thalamo-cortical and cerebellar pathways (p<0.05, FDR corrected). Furthermore, there was a significant negative relationship between right orbitofrontal gyrus (OFG) white matter volume and the severity of patients' clinical symptoms, as assessed with the PDSS. A significant positive relationship was also observed between patients' right OFG volumes and their scores on the GAF. Our results suggest that volumetric reductions in widespread white matter regions may play an important role in the pathology of PD. In particular, our results suggest that structural white matter abnormalities in the right OFG may contribute to the social, personal and occupational dysfunction typically experienced by patients with PD.
Requirement for DNA Ligase IV during Embryonic Neuronal Development

The embryonic ventricular and subventricular zones (VZ/SVZ) contain the neuronal stem and progenitor cells and undergo rapid proliferation. The intermediate zone (IZ) contains nonreplicating, differentiated cells. The VZ/SVZ is hypersensitive to radiation-induced apoptosis. Ablation of DNA non-homologous end-joining (NHEJ) proteins, XRCC4 or DNA ligase IV (LigIV), confers ataxia telangiectasia mutated (ATM)-dependent apoptosis predominantly in the IZ. We examine the mechanistic basis underlying these distinct sensitivities using a viable LigIV (Lig4Y288C) mouse, which permits an examination of the DNA damage responses in the embryonic and adult brain. Via combined analysis of DNA breakage, apoptosis, and cell-cycle checkpoint control in tissues, we show that apoptosis in the VZ/SVZ and IZ is activated by low numbers of DNA double-strand breaks (DSBs). Unexpectedly, high sensitivity in the VZ/SVZ arises from sensitive activation of ATM-dependent apoptosis plus an ATM-independent process. In contrast, the IZ appears to be hypersensitive to persistent DSBs. NHEJ functions efficiently in both compartments. The VZ/SVZ and IZ regions incur high endogenous DNA breakage, which correlates with VZ proliferation. We demonstrate a functional G2/M checkpoint in VZ/SVZ cells and show that it is not activated by low numbers of DSBs, allowing damaged VZ/SVZ cells to transit into the IZ. We propose a novel model in which microcephaly in LIG4 syndrome arises from sensitive apoptotic induction from persisting DSBs in the IZ, which arise from high endogenous breakage in the VZ/SVZ and transit of damaged cells to the IZ. The VZ/SVZ, in contrast, is highly sensitive to acute radiation-induced DSB formation.
The MaSuRCA genome assembler

MOTIVATION Second-generation sequencing technologies produce high coverage of the genome by short reads at a low cost, which has prompted development of new assembly methods. In particular, multiple algorithms based on de Bruijn graphs have been shown to be effective for the assembly problem. In this article, we describe a new hybrid approach that has the computational efficiency of de Bruijn graph methods and the flexibility of overlap-based assembly strategies, and which allows variable read lengths while tolerating a significant level of sequencing error. Our method transforms large numbers of paired-end reads into a much smaller number of longer 'super-reads'. The use of super-reads allows us to assemble combinations of Illumina reads of differing lengths together with longer reads from 454 and Sanger sequencing technologies, making it one of the few assemblers capable of handling such mixtures. We call our system the Maryland Super-Read Celera Assembler (abbreviated MaSuRCA and pronounced 'mazurka'). RESULTS We evaluate the performance of MaSuRCA against two of the most widely used assemblers for Illumina data, Allpaths-LG and SOAPdenovo2, on two datasets from organisms for which high-quality assemblies are available: the bacterium Rhodobacter sphaeroides and chromosome 16 of the mouse genome. We show that MaSuRCA performs on par or better than Allpaths-LG and significantly better than SOAPdenovo on these data, when evaluated against the finished sequence. We then show that MaSuRCA can significantly improve its assemblies when the original data are augmented with long reads. AVAILABILITY MaSuRCA is available as open-source code at ftp://ftp.genome. umd.edu/pub/MaSuRCA/. Previous (pre-publication) releases have been publicly available for over a year. CONTACT alekseyz@ipst.umd.edu. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Temporal Trends in the Use and Comparative Effectiveness of Direct Oral Anticoagulant Agents Versus Warfarin for Nonvalvular Atrial Fibrillation: A Canadian Population‐Based Study

Background Direct oral anticoagulants (DOACs) are noninferior to warfarin for stroke prevention in atrial fibrillation (AF). We aimed to determine the population risk of stroke and death in incident AF, stratified by anticoagulation status and type, and the temporal trends of oral anticoagulation practice in the post‐DOAC approval period. Methods and Results We conducted a population‐based cohort study of incident nonvalvular AF cases using administrative health data in Alberta, Canada. We used Cox proportional hazards modeling with anticoagulation status as a time‐varying exposure and adjusted for age (continuous), sex, congestive heart failure, hypertension, diabetes mellitus, prior transient ischemic attack or ischemic stroke, myocardial infarction, peripheral artery disease, and chronic kidney disease. Primary outcome was the composite of stroke and death. Among 34 965 patients with incident AF (56.0% male, median age 73 years), relative to warfarin, DOAC use was associated with decreased risk of all stroke and death (hazard ratio: 0.90; 95% confidence interval, 0.83–0.97) and decreased hemorrhagic stroke (hazard ratio: 0.60; 95% confidence interval, 0.40–0.91]) but a similar risk of ischemic stroke (hazard ratio: 1.12; 95% confidence interval, 0.94–1.34]). During this time period, DOAC use increased rapidly, surpassing warfarin, but the total oral anticoagulation use in the population remained stable, even in the subgroup with the highest thromboembolic risk. Conclusions In a real‐world population‐based study of patients with incident AF, anticoagulation with DOACs was associated with decreased risk of stroke and death compared with warfarin. Despite a rapid uptake of DOACs in clinical practice, the total proportion of AF patients on anticoagulation has remained stable, even in high‐risk patients.
Decelerated IT Innovation: Negotiating Global IT Innovation Initiatives in Local Settings

We examine an attempt to implement a joint IT infrastructure between a large multi-national high-technology manufacturing firm and a large mining firm. We identify several occasions where innovation failed and the manufacturing firm could not establish a new network of partnerships with their customers enabled by the introduced IT capabilities. Our study highlights a change in the forms of materiality within used control system technology - a shift from controlling isolated manufacturing devices into controlling networks of "smart" devices connected by Internet computing. While the new networked and ubiquitous computing infrastructure holds a potential for radical service innovation, this potential has not been fulfilled. One of the factors accounting for the failure is that the global IT innovation strategy was not well aligned to the local context and existing networks of actors. To explain this unfolding of events we coin the term "decelerated innovation".
Occurrence of circulating immune complexes in beta-thalassaemia major.

The presence of circulating soluble immune complexes and the level of complement were investigated in sera from 21 patients with beta-thalassaemia major, including both splenectomised and nonsplenectomised patients. A high level of immune complexes was found in half of these cases. Reduced complement levels were seen less frequently. There was no correlation between the presence of circulating immune complexes, decreased complement levels, and thpresence or absence of the spleen. The level of immune complexes increased with the age ofthe individual, i.e. with the duration of the disease.
The Spectrum of Epstein-Barr Virus-Associated Lymphoproliferative Disease in Korea: Incidence of Disease Entities by Age Groups

This study is to identify the spectrum of Epstein-Barr virus (EBV)-positive lymphoproliferative diseases (LPD) and relationships between these diseases in Korea. The EBV status and clinicopathology of 764 patients, including acute EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH), chronic active EBV (CAEBV) infections, B-LPD arising in chronic latent EBV infection, T & natural killer (NK) cell non-Hodgkin's lymphomas (NHL), B-NHLs, and Hodgkin's lymphomas (HD), were analyzed. T or NK cell NHLs were the most common forms of EBV-positive NHLs (107/167, 64%); among these, nasal-type NK/T cell lymphomas were the most common (89/107, 83%). According to the age, Burkitt's lymphoma was the most common in early childhood; in teenagers, chronic (active) EBV infection-associated LPD was the most common type. The incidence of NK/T cell lymphoma began to increase from the twenties and formed the major type of EBV-associated tumor throughout life. Diffuse large B cell lymphoma formed the major type in the sixties and seventies. In conclusion, primary infections in early childhood are complicated by the development of CAEBV infections that are main predisposing factors for EBV-associated T or NK cell malignancies in young adults. In old patients, decreased immunity associated with old age and environmental cofactors may provoke the development of peripheral T cell lymphoma, unspecified, and diffuse large B cell lymphoma.
The Relationships between Anabolic Hormones and Body Composition in Middle-Aged and Elderly Men with Prediabetes: A Cross-Sectional Study

The influence of anabolic hormones and body composition in men with prediabetes (PD) is unknown. In a cross-sectional study we investigated the relationships between total testosterone (TT), calculated free testosterone (cFT), dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor 1 (IGF-1) and body composition assessed using dual-energy X-ray absorptiometry (DXA) method in 84 patients with PD (40–80 years) and 56 men in control group. Patients with PD had lower TT, cFT, and DHEAS levels but similar IGF-1 levels in both groups. Patients with PD presented the higher total and abdominal fat as well as the lower total and abdominal lean than control (p < 0.02, p < 0.01, p < 0.05, and p < 0.02, resp.). We observed negative relationship between TT and total fat (p = 0.014) and positive with abdominal lean mass (p = 0.034), while cFT was negatively associated with abdominal (p = 0.02), trunk (p = 0.024), and leg fat (p = 0.037) and positively associated with total (p = 0.022) and trunk lean (p = 0.024). DHEAS were negatively associated with total fat (p = 0.045), and IGF-1 were positively associated with abdominal (p = 0.003) and leg lean (p = 0.015). In conclusion, the lowered anabolic hormones are involved in body composition rearrangement in men with PD. Further studies are needed to establish whether the androgen replacement therapy would be beneficial in men with PD.