Miracle-dz/UniFAR-FTUs huggingface dataset:
Occlusive Fungal Tracheitis in 4 Captive Bottlenose Dolphins (Tursiops truncatus)

Respiratory disease is common in dolphins, primarily affecting pulmonary parenchyma and sparing large airways. Over a 10-year period, 4 captive adult bottlenose dolphins succumbed to chronic, progressive respiratory disease with atypical recurrent upper respiratory signs. All dolphins had severe, segmental to circumferential fibrosing tracheitis that decreased luminal diameter. Histologically, tracheal cartilage, submucosa, and mucosa were distorted and replaced by extensive fibrosis and pyogranulomatous inflammation centered on fungal hyphae. In 3 of 4 cases, hyphae were morphologically compatible with Aspergillus spp and confirmed by culture in 2 cases. Amplification of fungal DNA from tracheal tissue was successful in one case, and sequences had approximately 98% homology to Aspergillus fumigatus. The remaining case had fungi compatible with zygomycetes; however, culture and polymerase chain reaction were unsuccessful. Lesions were evaluated immunohistochemically using antibodies specific to Aspergillus spp. Aspergillus-like hyphae labeled positively, while presumed zygomycetes did not. These cases represent a novel manifestation of respiratory mycoses in bottlenose dolphins.
Framing the Problem of Sex Trafficking

News media play an important role in explaining the issue of sex trafficking and may influence discourse among the public and policymakers. Understanding the ways that mass media address sex trafficking has implications for the news industry and the global status of women. This study, a quantitative content analysis, analyzed news coverage of sex trafficking in major US newspapers to understand how the issue was framed during a year of coverage. Using Entman's typology to classify the function of frames, the study focused on how news coverage defined the problem of sex trafficking and identified the remedy. The study found that news coverage of trafficking was overwhelmingly framed as a crime issue (episodic not thematic) and proposed no remedies. Most news coverage favored official sources. Survivors of trafficking and their advocates were the least heard-from sources. The authors argue ultimately that if media are to fulfill their watchdog role where trafficking is concerned, a wider range of news frames and sources is needed.
Charge‐Transport Anisotropy Due to Grain Boundaries in Directionally Crystallized Thin Films of Regioregular Poly(3‐hexylthiophene)

Figure 1: Phase mode AFM image of directionally crystallized P3HT, revealing the unique grain structure. The white arrow indicates the direction of the fiber axis and polymer chain axis. The scan is 4 by 4 μm. (Left) The cartoon shows a possible orientation of crystallites within the directionally crystallized film, as derived from XRD. Red crystallites are “edge-on” with their pi-pi stacking repeat in the plane of the substrate. Grey crystallites are termed “face-on,” with their pi-pi stacking repeat out of the plane of the substrate. In this cartoon of the grains, the longest axis is long the polymer chain backbone (001), the next longest along the alkyl-stacking direction (100) and the shortest along the pi-pi stacking direction (010), see Figure 2b for reference. (Right) Charge Transport Anisotropy Due to Grain Boundaries in Directionally Crystallized Thin Films of Regio-Regular Poly(3-hexylthiophene)
An exploratory study of eye typing fundamentals: dwell time, text entry rate, errors, and workload

Although eye typing (typing on an on-screen keyboard via one's eyes as they are tracked by an eye tracker) has been studied for more than three decades now, we still know relatively little about it from the users' point of view. Standard metrics such as words per minute and keystrokes per character yield information only about the effectiveness of the technology and the interaction techniques developed for eye typing. We conducted an extensive study with almost five hours of eye typing per participant and report on extended qualitative and quantitative analysis of the relationship of dwell time, text entry rate, errors made, and workload experienced by the participants. The analysis method is comprehensive and stresses the need to consider different metrics in unison. The results highlight the importance of catering for individual differences and lead to suggestions for improvements in the interface.
The Effects of Task Involvement Load on L2 Incidental Vocabulary Learning: A Meta‐Analytic Study

This meta-analytic study provides a systematic statistical synthesis of the effects of output tasks on second or foreign incidental vocabulary learning. A total of 12 studies were included in this meta-analysis. Five mediator variables were examined: design quality, types of output task, time on task, genres of text, and text-target word ratios. Results show that language learners who completed an output task outperformed those who only read a text. Results also support the involvement load hypothesis: Language learners who performed a task with a higher degree of involvement load, gained more vocabulary. Studies with high and medium levels of design quality were more likely to detect statistically significant differences among groups with different output tasks, compared to studies with a low level of design quality. Furthermore, results indicate that time on task had positive effects on vocabulary learning. Learners who read a combination of expository and narrative text gained more vocabulary than those who only read either an expository or narrative text. Learners who read a text with text-target word ratios of less than or equal to 2% did not learn significantly more vocabulary than those who read a text with a ratio of 2% to 5%. [ABSTRACT FROM AUTHOR]
Discrepant Attentional Biases Toward Sexual Stimuli

There are at least two types of response to stimuli: an automatic response that happens before conscious thought (a Type 1 response) and a deliberative, intentional response (a Type 2 response). These responses are related to behavior associated with the affective loading of the stimulus presented. Prior research has shown, for example, that a Type 1 tendency to spend more time looking at fear-provoking stimuli is associated with higher levels of general anxiety, while a Type 2 tendency to spend more time looking away from happy faces is associated with higher levels of depressive symptoms. Some stimuli categories elicit mixed responses, indicated by discrepant Type 1 and Type 2 responses. For example, alcoholics in recovery tend to look toward alcohol-themed pictures in the first 200 milliseconds, then look away. This suggests that alcoholics in recovery have an automatic draw to alcohol that is overridden by the conscious application of a cognitive schema to avoid alcohol. Sexual response studies to date have measured Type 1 and Type 2 responses separately; however, no study has yet measured both types of response within the same person. This study was the first to examine both Type 1 and Type 2 responses to erotic stimuli within the same individual as a test of within-individual variation of attentional responses to sexual stimuli. Results do not support a connection between either attentional bias or conflicting Type 1 and Type 2 responses and sexual desire or distress. Implications of these non-findings are discussed in theoretical and methodological contexts, and future research is suggested.
Clinical outcomes and patient satisfaction following total joint replacement in haemophilia – 23‐year experience in knees, hips and elbows

Summary. Joint replacement surgery is an available option for end‐stage haemophilic arthropathy. However, reports with long‐term follow‐up are limited. Moreover, patient satisfaction in this setting has never been measured. We share our institution’s experience with joint arthroplasty in haemophilic arthropathy and report on clinical outcomes and patient satisfaction. Between 1985 and 2007, 65 consecutive joints in 45 patients (mean age: 48.6; range: 22–83) underwent joint replacement surgery. Of these, 40 total knee replacements in 31 patients, 18 total hip replacements in 16 patients and 6 total elbow replacements in 3 patients were included. Average follow‐up was 10.7 years (2.4–24.3). Charts were reviewed retrospectively and patients were asked to return for clinical assessment and completion of questionnaires. According to the Knee Society clinical score, postoperative results were good to excellent in 83% of knees. According to the Harris Hip Score, results were good to excellent in 31% of hips. According to the Mayo Elbow Performance Score, results were good to excellent in 83% of elbows. Complication rates are higher than in the non‐haemophilic population, while prosthesis survival rates are lower. Patient satisfaction with pain relief is higher than satisfaction with functional improvement. For 88% of joints, patients are willing to have the same operation again. This study confirms previous knowledge on the role of total joint arthroplasty in haemophilic arthropathy. Despite high complication rates and modest functional outcomes, the operations are valuable for achieving pain relief. In general, patients find that risks are outweighed by the benefits.
Tibial plateau levelling osteotomy in eleven cats with cranial cruciate ligament rupture

Summary Objective: To report the surgical procedure, intra- and postoperative complications, and short-term follow-up of tibial plateau levelling osteotomy (TPLO) in feline patients with cranial cruciate ligament (CrCL) rupture using a 2.0 or 2.4 mm Synthes® TPLO plate. Study design: Prospective study. Material and methods: Eleven cats with a CrCL rupture were included in the study. Inspection of intra-articular structures was carried out via arthroscopy or arthrotomy. Each patient was re-examined one and 10 days after surgery. Orthopaedic examination and follow-up radiographs were obtained four to 12 weeks postoperatively. Results: Two meniscopathies and one partial CrCL rupture were detected. Minor intra- operative complications occurred in five cats (suboptimal positioning of the plate [n = 3], proximal fibular fracture [n = 1], a visible osteotomy gap [n = 1]). Postoperatively, minor complications were detected in three cats (mild patellar desmitis [n = 2], superficial wound infection [n = 1]). No additional surgical reintervention, graded as major complication, was necessary. Four to eight weeks postoperatively, all cats showed no to mild intermittent lameness. Complete bone union was apparent within four to 12 weeks. Owners reported a high level of comfort and mobility during the last follow-up. Conclusion: The preliminary results of this study support the use of TPLO in cats, but larger case numbers are needed to evaluate its practicability, as well as long-term outcome (>1 year), especially evaluating the development and the clinical relevance of osteoarthritis. Supplementary Material to this article is available online at http://dx.doi. org/10.3415/VCOT-15-11-0184.
A phase I trial of intrahepatic Verapamil and doxorubicin. Regional therapy to overcome multidrug resistance

Background. Verapamil can modulate multidrug resistance in vitro, but only at levels that are not tolerable when administered systemically. Regional strategies of drug administration may permit the delivery of high concentrations of a drug to specific areas with lower systemic levels. Colorectal cancers typically express the multidrug resistance phenotype.
Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators

We performed a systematic characterization of the hepatic vitamin A storage in mammals and birds of the Svalbard archipelago and Greenland. The liver of top predators, including polar bear, arctic fox, bearded seal, and glaucous gull, contained about 10–20 times more vitamin A than the liver of all other arctic animals studied, as well as their genetically related continental top predators. The values are also high compared to normal human and experimental animals like mouse and rat. This massive amount of hepatic vitamin A was located in large autofluorescent lipid droplets in hepatic stellate cells (HSCs; also called vitamin A‐storing cells, lipocytes, interstitial cells, fat‐storing cells, or Ito cells). The droplets made up most of the cells' cytoplasm. The development of such an efficient vitamin A‐storing mechanism in HSCs may have contributed to the survival of top predators in the extreme environment of the arctic. These animals demonstrated no signs of hypervitaminosis A. We suggest that HSCs have capacity to take‐up and store large amounts of vitamin A, which may play a pivotal role in maintenance of the food web, food chain, biodiversity, and eventually ecology of the arctic. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
All together now? College students' preferred project group grading procedures.

Three hundred sixty undergraduate students were randomly assigned to evaluate 1 of 12 versions of a hypothetical college syllabus from a course in which student project groups were used. As hypothesized, students reported the highest course-enrollment intentions and most positive perceptions of the group grading procedure when both individual and group performance on the group project was evaluated. In addition, students with low grade point averages (GPAs) exhibited stronger course-enrollment intentions than students with high GPAs when group work accounted for a high percentage (50%) of students' course grades and when group performance was evaluated. Contrary to hypotheses, students did not prefer courses in which they had input into the grading of their group work. Implications for the use of group grading procedures are discussed, in addition to future research directions.
Fair play: creating a better learning climate for social work students in social care settings

This paper describes a pilot study and subsequent evaluation undertaken by the author which arose from his experiences as a practice teacher working with a student in a day care facility. The catalyst for the study arose from one student's comments about the confusion he and others on the placement site experienced regarding his role as a social work student in a setting where there was no defined social work role. It led to a study of students' views in a range of settings across South & East Belfast Trust, some of which may be deemed to be ‘social work settings’, i.e. with a defined social work role, while others may be considered ‘social care settings’, i.e. with no defined social work role. The aim of the study and subsequent evaluation was to consider problematic issues which arose for students in social care settings and how the quality of learning opportunities for them could be improved.
Trimeric binding of the 70-kD uncoating ATPase to the vertices of clathrin triskelia: a candidate intermediate in the vesicle uncoating reaction

Clathrin-coated vesicles were uncoated with the 70-kD "uncoating ATPase" from bovine brain, and the molecular products were visualized by freeze-etch electron microscopy. This yielded images of released clathrin triskelia with up to three 70-kD uncoating ATPase molecules bound to their vertices. Likewise, incubation of soluble clathrin triskelia with purified uncoating ATPase also led to trimeric binding of the ATPase to the vertices of clathrin triskelia. However, this occurred only when either EDTA or nonhydrolyzable analogues of ATP were present, in which case the ATPase also appeared to self-associate. When ATP was present instead, no 70-kD ATPases could be found on clathrin triskelia and all ATPases remained monomeric. These observations support the notion that ATP controls an allosteric conversion of the 70- kD uncoating ATPase between two different molecular conformations, an ATP-charged state in which the molecule has relatively low affinity for itself as well as low affinity for clathrin, and an ATP-discharged state in which both of these affinities are high. We presume that in vivo, the latter condition is brought about by ATP hydrolysis and product release, at which point the ATPase will bind tightly to clathrin and/or self-associate. We further propose that these reactions, when occurring in concert within a clathrin lattice, will tend to destabilize it by a mechanism we call "protein polymer competition". We stress the analogies between such a mechanism of uncoating and the ATP-driven events in muscle contraction. Finally, we show that under experimental conditions in which the uncoating ATPase fully removes the coats from brain coated vesicles, identical aliquots of the enzyme do not affect plasmalemmal coated pits in situ. This remarkable selectivity, the mechanism of which remains a complete mystery, is at least consistent with the idea that the 70-kD ATPase indeed plays a role in uncoating coated vesicles after they have formed in vivo.
An ultrasound therapy system for hyperlipidemia prevention

Ultrasound has been widely applied in the field of medical and healthcare. This paper assumes that noninvasive ultrasound reduces blood lipid levels and inhibits thrombosis in vessels. An apparatus with adjustable parameters was designed for ultrasound treatment. The system consists of five parts: ultrasound transducer, waveform generation, matching network, control module and power supply. The apparatus test showed that the system is stable and adjustable. The hyperlipidemia rat models were randomized to control group, medication group (Simvastatin) and ultrasound group (40 KHz, 2.5W/cm2) respectively. The blood lipid concentration of the ultrasound group was lower than the control and medication group (p<;0.05). Noninvasive ultrasonic treatment reduced blood lipid concentration significantly. The animal experiment result preliminary indicated that ultrasound can be a safe and effective method to hyperlipidemia intervention.
Competitor - an offender or victim of doping control as viewed by young athletes

Competitor - an offender or victim of doping control as viewed by young athletes Study aim: To evaluate the perception of motivations and responsibility for doping abuse by young athletes. Material and methods: A group of male volleyball players (n = 44) and of female combat athletes (n = 26), all aged 15 - 17 years and having 4 - 8 years of training experience, were studied. By applying questionnaire technique, two issues were studied: responsibility of the athlete and of the coach/medical team, and the motivations of doping abuse. Results: Young athletes decidedly declined to pronounce either side not guilty of doping abuse, the male subjects being more critical and severe than the female ones. All of them attributed doping abuse to exaggerated ambitions of athletes and, to a much lesser extent to the pressure of sport environment. Conclusions: The results enable a better understanding of psychological mechanisms of giving in to the temptation of doping abuse and, thus, may help preventing it.
Exploring the nature of language anxiety: Experiences of non-native English-speaking college students in the United States

This Dissertation is protected by copyright and/or related rights. It has been brought to you by ScholarWorks@UNO with permission from the rights-holder(s). You are free to use this Dissertation in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s) directly, unless additional rights are indicated by a Creative Commons license in the record and/ or on the work itself.
Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons

The mechanism underlying the upregulation of NMDA receptor function by group I metabotropic glutamate receptors (mGluRs), including mGluR1 and 5, is not known. Here we show that in cortical neurons, brief selective activation of group I mGluRs with (S)-3,5-dihydroxy-phenylglycine (DHPG) induced a Ca2+–calmodulin-dependent activation of Pyk2/CAKβ and the Src-family kinases Src and Fyn that was independent of protein kinase C (PKC). Activation of Pyk2 and Src/Fyn kinases led to increased tyrosine phosphorylation of NMDA receptor subunits 2A and B (NR2A/B) and was blocked by a selective mGluR1 antagonist, 7-(hydroxyamino)cyclopropa[b]chromen-1a-carboxylate ethyl ester, but not an mGluR5 antagonist, 2-methyl-6-(phenylethynyl)pyridine. Functional linkage between mGluR1 activation and NR2A tyrosine phosphorylation through Pyk2 and Src was also demonstrated after expression of these elements in human embryonic kidney 293 cells. Supporting functional consequences, selective activation of mGluR1 by DHPG induced a potentiation of NMDA receptor-mediated currents that was blocked by inhibiting mGluR1 or Src-family kinases. Furthermore, antagonizing calmodulin or mGluR1, but not PKC, reduced the basal tyrosine phosphorylation levels of Pyk2 and Src, suggesting that mGluR1 may control the basal activity of these kinases and thus the tyrosine phosphorylation levels of NMDA receptors.
A Model of Climate Belief Profiles: How Much Does It Matter If People Question Human Causation?

Despite the weight of scientific evidence presented in recent assessment reports of the IPCC, there remains some skepticism among the public that the climate is changing and whether such change is caused by human activity. We modeled climate change belief profiles using Latent Class Analysis in a New Zealand national probability sample (N = 6,072). Roughly 50% of New Zealanders believed that climate change was real and caused by humans, with 30% undecided. The majority of New Zealanders believe that climate change is real and likely caused by humans, with one in six remaining skeptical. We identified two types of climate skeptics, those who did not believe in climate change (7%), and those who believed climate change was real but not caused by humans (10%). Beliefs about the reality of climate change were more predictive than beliefs about human cause of support for carbon emissions policy and self-reported proenvironmental behavior. Our model indicates that persuading people about the reality of climate change will predict greater incremental variance in behavior and policy attitudes than persuading people of its human cause; although persuading people of both will be still more effective due to the synergistic interaction of these dual beliefs.
Serial measurement of the circulating levels of tumour necrosis factor and its soluble receptors 1 and 2 for monitoring leprosy patients during multidrug treatment

Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host response to the aetiologic agent, Mycobacterium leprae . The induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, primarily through the action of cytokines. The purpose of the present study was to evaluate the serum levels of tumour necrosis factor (TNF)-α and its soluble receptors (sTNF-R1 and sTNF-R2) in leprosy patients at different stages of multidrug treatment (MDT) in comparison with non-infected individuals and to determine their role as putative biomarkers of the severity of leprosy or the treatment response. ELISA was used to measure the levels of these molecules in 30 healthy controls and 37 leprosy patients at the time of diagnosis and during and after MDT. Our results showed increases in the serum levels of TNF-α and sTNF-R2 in infected individuals in comparison with controls. The levels of TNF-α, but not sTNF-R2, decreased with treatment. The current results corroborate previous reports of elevated serum levels of TNF-α in leprosy and suggest a role for sTNF-R2 in the control of this cytokine during MDT.