Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy.

OBJECTIVE The aim of the current study was to determine the validity of the Toronto Clinical Scoring System (CSS) in reflecting the presence and severity of diabetic peripheral sensorimotor polyneuropathy (DSP) as determined by myelinated fiber density (FD) on sural nerve biopsy. RESEARCH DESIGN AND METHODS Eighty-nine patients with both type 1 and type 2 diabetes, ascertained from a large therapeutic randomized controlled trial, were included in this cross-sectional, observational cohort study. Morphological severity of DSP was expressed as the FD in the sural nerve biopsy. The Toronto CSS was applied to all patients to determine a clinical neuropathy score. General linear regression models were used to assess the relationship between the morphological severity of DSP and the Toronto CSS. RESULTS The Toronto CSS showed a significant negative correlation with sural nerve FD (R(2) = 0.256, P < 0.0001). The Toronto CSS was lower in those with better glycemic control (HbA(1c) </=8%). Sural nerve FD and the Toronto CSS showed strong correlations with electrophysiology, by both summed amplitude and summed conduction velocity values. CONCLUSIONS The Toronto CSS is a valid instrument to reflect the presence and severity of DSP as measured by sural nerve morphology and electrophysiology. The results of the current study underscore the interrelationships between clinical deficits, electrophysiological findings, and morphological changes in DSP. This evidence suggests that the Toronto CSS may prove useful in documenting and monitoring DSP in the clinic and in clinical research trials.
Population Genetics of Trypanosoma evansi from Camel in the Sudan

Genetic variation of microsatellite loci is a widely used method for the analysis of population genetic structure of microorganisms. We have investigated genetic variation at 15 microsatellite loci of T. evansi isolated from camels in Sudan and Kenya to evaluate the genetic information partitioned within and between individuals and between sites. We detected a strong signal of isolation by distance across the area sampled. The results also indicate that either, and as expected, T. evansi is purely clonal and structured in small units at very local scales and that there are numerous allelic dropouts in the data, or that this species often sexually recombines without the need of the “normal” definitive host, the tsetse fly or as the recurrent immigration from sexually recombined T. brucei brucei. Though the first hypothesis is the most likely, discriminating between these two incompatible hypotheses will require further studies at much localized scales.
Comparison of measured and radar-equivalent gamma DSDs to investigate the effect of gamma raindrop size distribution assumption on the rain rates

The knowledge of rain drop size distribution (DSD) has a wide range of applications in earth sciences such as precipitation physics, hydrology, and agricultural and soil sciences. DSD is notoriously important in developing retrieval algorithms in precipitation remote sensing. In radar meteorology all the radar rainfall algorithms are, at different extent, sensitive to DSD variability. Although literature reports different parametric forms to model the measured DSD, to date, the commonly most used distribution is the three-parameter gamma (Ulbrich, 1983). The goal of this study is to evaluate the error, in terms of rain rate, due to this assumption. A methodology was set up to compare the rain rates of a disdrometer-measured DSD and a simulated gamma DSD equivalent in terms of radar measurements (reflectivity factor, Zh, differential reflectivity, Zdr, and specific differential phase shift, Kdp). The differences, expressed in terms of normalized standard error (NSE) and normalized bias (NB) computed between the two rain rates will provide an indication about the influence of the gamma assumption on rain rate estimation. The influence of other factors, such as the raindrop shape model, the integration time interval, the radar frequency, and the influence of disdrometer sampling error are also investigated.
Anchoring of Protein Kinase A-Regulatory Subunit IIα to Subapically Positioned Centrosomes Mediates Apical Bile Canalicular Lumen Development in Response to Oncostatin M but Not cAMP

Oncostatin M and cAMP signaling stimulate apical surface-directed membrane trafficking and apical lumen development in hepatocytes, both in a protein kinase A (PKA)-dependent manner. Here, we show that oncostatin M, but not cAMP, promotes the A-kinase anchoring protein (AKAP)-dependent anchoring of the PKA regulatory subunit (R)IIα to subapical centrosomes and that this requires extracellular signal-regulated kinase 2 activation. Stable expression of the RII-displacing peptide AKAP-IS, but not a scrambled peptide, inhibits the association of RIIα with centrosomal AKAPs and results in the repositioning of the centrosome from a subapical to a perinuclear location. Concomitantly, common endosomes, but not apical recycling endosomes, are repositioned from a subapical to a perinuclear location, without significant effects on constitutive or oncostatin M-stimulated basolateral-to-apical transcytosis. Importantly, however, the expression of the AKAP-IS peptide completely blocks oncostatin M-, but not cAMP-stimulated apical lumen development. Together, the data suggest that centrosomal anchoring of RIIα and the interrelated subapical positioning of these centrosomes is required for oncostatin M-, but not cAMP-mediated, bile canalicular lumen development in a manner that is uncoupled from oncostatin M-stimulated apical lumen-directed membrane trafficking. The results also imply that multiple PKA-mediated signaling pathways control apical lumen development and that subapical centrosome positioning is important in some of these pathways.
RobotAssist - A platform for human robot interaction research

This paper presents RobotAssist, a robotic platform designed for use in human robot interaction research and for entry into Robocup@Home competition. The core autonomy of the system is implemented as a component based software framework that allows for integration of operating system independent components, is designed to be expandable and integrates several layers of reasoning. The approaches taken to develop the core capabilities of the platform are described, namely: path planning in a social context, Simultaneous Localisation and Mapping (SLAM), human cue sensing and perception, manipulatable object detection and manipulation.
Comprehensive Study of Homicides in South Delhi, 1969–79

The present study was undertaken by the Department of Forensic Medicine, All India Institute of Medical Sciences (AIIMS) to find out the trends in homicides during the years 1969–79. Out of 4837 medico-legal autopsies conducted during the above-mentioned period, 140 cases (2.8 per cent) were of homicidal deaths. The commonest age group of the victims was 21–30 years (39.25 per cent) followed by 31–40 years (20 per cent). Males were victimized seven times more than females. Winter was the commonest season for the crime and most homicides occurred during the night. Most deaths occurred at the scene of the event. In our series blunt force injury was the commonest type (41.42 per cent) followed by stab injury (31.42 per cent). Defence wounds were present in 28.58 per cent of cases. Robbery and financial gain were the commonest type (37.1 per cent) of motive for the crime.
MU-MISO Transmission with Limited Feedback

Downlink multi-user transmission techniques that allow several users to be served simultaneously in frequency and time have been recognized as a promising means to increase system capacity. However they require accurate channel state information (CSI) at the base station (BS) such that appropriate signal processing can be performed to separate multiple users in the space domain. In practice however, CSI cannot be perfectly known to the BS due to the capacity-limited feedback channel in FDD systems for instance. In this letter we investigate multiuser multiple-input single-output (MU-MISO) transmission with limited feedback. In particular we identify the useful information that the BS needs to deal with inter-user interference and a codebook design is derived accordingly. In addition, an adaptive threshold-based feedback approach is proposed, where only users with good feedback quality are allowed to do feedback. It is shown that the adaptive scheme can effectively improve the system performance given a fixed number of feedback bits.
Mitigating the Inevitable Failure of Knowledge Representation

This paper is a continuation of a previous paper on self-modeling systems, concerning mitigation methods for the Get Stuck Theorems, which are powerful theorems about the limits of knowledge representation. The First Get Stuck Theorem says that since there are only finitely many data structures of any given size, it follows that as a system tries to save more and more data / information / knowledge, the structures necessarily get larger, and eventually they are too large for effective computation.The mitigations we described are Behavior Mining, which is about building models of the system and environment behavior, Model Deficiency Analysis, which is about assessing the efficacy of those models and determining how to improve them, Knowledge Refactoring, which is about restructuring the saved data for more efficient access and smaller storage, and Constructive Forgetting, which is about explicitly discarding some data that is deemed to be less critical.We argue that these classes of mitigations, and a couple of new ones, can help a system retain effectively computable knowledge structures in a dynamic environment at higher levels of difficulty (of course, as the environment gets more dynamic, all systems, including individual biological organisms and even species, eventually fail).
Inference of tidal elevation in shallow water using a vessel‐towed acoustic Doppler current profiler

Vessel-towed acoustic Doppler current profilers (ADCPs) have been widely used to measure velocity profiles. Since the instrument is usually mounted on a catamaran floating on the surface, previous studies have used the water surface as the reference level from which the vertical coordinate for the velocity profile is defined. However, because of the tidal oscillation, the vertical coordinate thus defined is time-dependent in an Earth-coordinate system, which introduces an error to the estimated harmonic constants for the velocity. As a result, the total transport will also be in error. This is particularly a problem in shallow waters where the tidal elevation is relatively large. Therefore tidal elevation needs to be resolved to make a correct harmonic analysis for the velocity. The present study is aimed at resolving the tidal elevation change in shallow water using a vessel-towed ADCP. Semidiurnal and diurnal tidal elevations across the lower Chesapeake Bay have been determined using a vessel-towed ADCP. Data from four cruises ranging from 25 to 92 hours in 1996 and 1997 are used. Water depth averaged every 30 s by the ADCP is studied by harmonic and statistical analysis. By selecting only the data within a narrow band (∼320 m) over the planned transect, we are able to improve the reliability of the data. We then grid the depth data along the 16 km transect into 200 equal segments and use harmonic analysis to resolve the semidiurnal and diurnal tidal variations within each segment. We find that (1) the depth data from the ADCP contain both semidiurnal and diurnal signals that can be resolved, from which the surface elevation can be inferred, (2) the major error appears to come from spatial variation of the depth, (3) the semidiurnal and diurnal tidal variations of elevation inferred over flat bottom topography account for almost 100% of the total variability, while those measurements over large bottom slopes account for a much lower percentage of the total variability, (4) at least 70% of the variability of depth can be explained by semidiurnal and diurnal tides if the bottom slope is smaller than 0.006, and (5) the spatial variation of both amplitude and phase of the elevation along the transect appears to be small with a slightly lower tidal amplitude at the south of the Chesapeake Bay entrance, consistent with the Coriolis effect. The inferred elevations from the ADCP readings are consistent with sea level measurements at a tide station 10 km inside the estuary.
Improving the usability of extruded wood-plastic composites by using modification technology

Hämäläinen, Kimmo Improving the usability of extruded wood-plastic composites by using modification technology Lappeenranta 2014 42p. + 5 original articles Acta Universitatis Lappeenrantaensis 608 Diss. Lappeenranta University of Technology ISBN 978-952-265-694-0, ISBN 978-952-265-695-7 (PDF) ISSN-L 1456-4491, ISSN 1456-4491 Using cellulosic reinforcement to produce plastic composites is a globally growing trend. One of such materials are wood-plastic composites, which are an extensively studied group of materials for which the global industry is looking for new applications. Issues such as bondability, durability and fire resistance still require development to improve the usability of the wood-plastic composite material. Improvement of the usability of wood-plastic composites is studied in this thesis through the effects of using selected modification technology in wood and plastic industry. The applied modification methods are surface modifications by mechanical abrasion and plasma, chemical impregnation of wood flour, and structural modification by the co-extrusion process. The study shows that the properties of WPC can be influenced by the selected modification methods. The selected methods are also found to be able to result as improvement in the properties of the material. The modification may also affect other than just the targeted properties of the end-product, either in a positive or a negative manner. Therefore modification as performance improvement should be considered as a case-
Gas hydrate technology: state of the art and future possibilities for Europe

Interest in natural gas hydrates has been steadily increasing over the last few decades, with the understanding that exploitation of this abundant unconventional source may help meet the ever-increasing energy demand and assist in reduction of CO2 emission (by replacing coal). Unfortunately, conventional technologies for oil and gas exploitation are not fully appropriate for the specific exploitation of gas hydrate. Consequently, the technology chain, from exploration through production to monitoring, needs to be further developed and adapted to the specific properties and conditions associated with gas hydrates, in order to allow for a commercially and environmentally sound extraction of gas from gas hydrate deposits. Various academic groups and companies within the European region have been heavily involved in theoretical and applied research of gas hydrate for more than a decade. To demonstrate this, Fig. 1.1 shows a selection of leading European institutes that are actively involved in gas hydrate research. A significant number of these institutes have been strongly involved in recent worldwide exploitation of gas hydrate, which are shown in Fig. 1.2 and summarized in Table 1.1. Despite the state of knowledge, no field trials have been carried out so far in European waters. MIGRATE (COST action ES1405) aims to pool together expertise of a large number of European research groups and industrial players to advance gas-hydrate related activity with the ultimate goal of preparing the setting for a field production test in European waters. This MIGRATE report presents an overview of current technologies related to gas hydrate exploration (Chapter 2), production (Chapter 3) and monitoring (Chapter 4), with an emphasis on European activity. This requires covering various activities within different disciplines, all of which contribute to the technology development needed for future cost-effective gas production. The report points out future research and work areas (Chapter 5) that would bridge existing knowledge gaps, through multinational collaboration and interdisciplinary approaches.
On the Ability of Humans to Apply Controlled Forces to Admittance-Type Devices

Human–robot collaborative systems have the potential to dramatically change many aspects of surgery, manufacturing, hazardous-material handling, and other dextrous tasks. We are particularly interested in precise manipulation tasks, which are typically performed under an admittance-control regime, where the controlled velocity of a non-backdrivable robot is proportional to the sensed user-applied force. During fast movements, there is a noticeable degradation in control precision and prior results have indicated that system velocity, and not system admittance, is the factor that is most correlated with force control precision. In this paper, we report evidence that system admittance is more important than velocity in determining the user's ability to control applied force and that both factors are less important than the force level itself, and we provide an explanation as to why prior results might have indicated otherwise. We find the conditions under which human force control performance is best when operating under admittance control. We also report the conditions under which human force control on a moving admittance-type device is indistinguishable from isometric force control, which can be used to design better device controllers.
Molecular characterization of 22 novel UDP‐N‐acetylglucosamine‐1‐phosphate transferase α‐ and β‐subunit (GNPTAB) gene mutations causing mucolipidosis types IIα/β and IIIα/β in 46 patients

Mutational analysis of the GNPTAB gene was performed in 46 apparently unrelated patients with mucolipidosis IIα/β or IIIα/β, characterized by the mistargeting of multiple lysosomal enzymes as a consequence of a UDP‐GlcNAc‐1‐phosphotransferase defect. The GNPTAB mutational spectrum comprised 25 distinct mutant alleles, 22 of which were novel, including 3 nonsense mutations (p.Q314X, p.R375X, p.Q507X), 5 missense mutations (p.I403T, p.C442Y, p.C461G, p.Q926P, p.L1001P), 6 microduplications (c.749dupA, c.857dupA, c.1191_1194dupGCTG, c.1206dupT, c.1331dupG, c.2220_2221dupGA) and 8 microdeletions (c.755_759delCCTCT, c.1399delG, c.1959_1962delTAGT, c.1965delC, c.2550_2554delGAAAA, c.3443_3446delTTTG, c.3487_3490delACAG, c.3523_3529delATGTTCC). All micro‐duplications/deletions were predicted to result in the premature termination of translation. A novel exonic SNP (c.303G>A; E101E) was identified which is predicted to create an SFRS1 (SF2/ASF) binding site that may be of potential functional/clinical relevance. This study of mutations in the GNPTAB gene, the largest yet reported, extends our knowledge of the mutational heterogeneity evident in MLIIα/β/MLIIIα/β. © 2009 Wiley‐Liss, Inc.
Cumulative Exposure to Lead in Relation to Cognitive Function in Older Women

Background Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women. Objective We examined biomarkers of lead exposure in relation to performance on a battery of cognitive tests among older women. Methods Patella and tibia bone lead—measures of cumulative exposure over many years—and blood lead, a measure of recent exposure, were assessed in 587 women 47–74 years of age. We assessed their cognitive function 5 years later using validated telephone interviews. Results Mean ± SD lead levels in tibia, patella, and blood were 10.5 ± 9.7 μg/g bone, 12.6 ± 11.6 μg/g bone, and 2.9 ± 1.9 μg/dL, respectively, consistent with community-level exposures. In multivariable-adjusted analyses of all cognitive tests combined, levels of all three lead biomarkers were associated with worse cognitive performance. The association between bone lead and letter fluency score differed dramatically from the other bone lead-cognitive score associations, and exclusion of this particular score from the combined analyses strengthened the associations between bone lead and cognitive performance. Results were statistically significant only for tibia lead: one SD increase in tibia lead corresponded to a 0.051-unit lower standardized summary cognitive score (95% confidence interval: −0.099 to −0.003; p = 0.04), similar to the difference in cognitive scores we observed between women who were 3 years apart in age. Conclusions These findings suggest that cumulative exposure to lead, even at low levels experienced in community settings, may have adverse consequences for women’s cognition in older age.
Azathioprine-induced carcinogenesis in mice according to Msh2 genotype.

BACKGROUND The thiopurine prodrug azathioprine is used extensively in cancer therapy. Exposure to this drug results in the selection of DNA mismatch repair-deficient cell clones in vitro. It has also been suggested that thiopurine drugs might constitute a risk factor for the emergence of human neoplasms displaying microsatellite instability (MSI) because of deficient DNA mismatch repair. METHODS Azathioprine was administered via drinking water (6-20 mg/kg body weight per day) to mice that were null (Msh2⁻(/)⁻; n = 27), heterozygous (Msh2(+/)⁻; n = 22), or wild type (Msh2(WT); n = 18) for the DNA mismatch repair gene Msh2. Control mice (45 Msh2⁻(/)⁻, 38 Msh2(+/)⁻, and 12 Msh2(WT)) received drinking water lacking azathioprine. The effect of azathioprine on tumorigenesis and survival of the mice was evaluated by Kaplan-Meier curves using log-rank and Gehan-Breslow-Wilcoxon tests. Mouse tumor samples were characterized by histology and immunophenotyping, and their MSI status was determined by polymerase chain reaction analysis of three noncoding microsatellite markers and by immunohistochemistry. Msh2 status of tumor samples was assessed by loss of heterozygosity analyses and sequencing after reverse transcription-polymerase chain reaction of the entire Msh2 coding sequence. All statistical tests were two-sided. RESULTS Most untreated Msh2(WT) and Msh2(+/)⁻ mice remained asymptomatic and alive at 250 days of age, whereas azathioprine-treated Msh2(WT) and Msh2(+/)⁻ mice developed lymphomas and died prematurely (median survival of 71 and 165 days of age, respectively). Azathioprine-treated Msh2(+/)⁻ mice developed diffuse lymphomas lacking Msh2 expression and displaying MSI due to somatic inactivation of the functional Msh2 allele by loss of heterozygosity or mutation. By contrast, azathioprine-treated Msh2(WT) mice displayed no obvious tumor phenotype, but histological examination showed microscopic splenic foci of neoplastic lymphoid cells that retained Msh2 expression and did not display MSI. Both untreated and azathioprine-treated Msh2⁻(/)⁻ mice had a reduced lifespan compared with untreated Msh2(WT) mice (median survival of 127 and 107 days of age, respectively) and developed lymphomas with MSI. CONCLUSION Azathioprine-induced carcinogenesis in mice depends on the number of functional copies of the Msh2 gene.