Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of season and latitude on in vitro vitamin D formation by sunlight in South Africa.

AIMS To assess the effect of season and latitude on the in vitro formation of previtamin D3 and vitamin D3 from 7-dehydrocholesterol (7-DHC) by sunlight in two cities in South Africa, Cape Town and Johannesburg. METHODS An in vitro study utilising vials containing 7-DHC, which were exposed to sunlight for a period of 1 hour between 8:00 and 17:00 on 1 day a month for a year. Previtamin D3 and vitamin D3 were separated from 7-DHC by high-performance liquid chromatography, and the amounts formed were calculated with the use of external standards. RESULTS A marked seasonal variation in vitamin D3 production was noted in Cape Town, with very little being formed during the winter months of April through September. In Johannesburg, in vitro formation changed little throughout the year, and was similar to that found in Cape Town during the summer. During sunlit hours, vitamin D3 production was maximal at midday and small quantities were still being formed between 8:00 and 9:00, and between 16:00 and 17:00 during the summer. During winter in Cape Town, peak formation at midday was less than one-third of that in Johannesburg, and negligible amounts were formed before 10:00 and after 15:00. CONCLUSIONS The previously documented seasonal variation in serum 25-hydroxyvitamin D recorded in patients in Johannesburg is probably a consequence of the increased clothing worn and the decreased time spent out of doors during winter, rather than decreased ultraviolet radiation reaching the earth. The limited in vitro formation of vitamin D3 during winter in Cape Town may have clinical implications insofar as the management of metabolic bone diseases like rickets and osteoporosis is concerned. Breast-fed infants resident in the area are likely to suffer from vitamin D deficiency rickets unless vitamin D supplements are provided, or the mothers are encouraged to take their children out of doors.
Retrograde double‐labeling study of the marnmillothalamic and the mammillotegmental projections in the rat

Collateral axonal branching from the medial or lateral mammillary nuclei to the anterior thalamus, Gudden's tegmental nuclei, the nucleus reticularis tegmenti pontis, and the medial pontine nucleus was studied using the fluores‐ cent retrograde double‐labeling method. One day after injection of Fast Blue into the anterior thalamic nuclei or Gudden's tegmental nuclei, Nuclear Yel‐ low was injected into Gudden's tegmental nuclei or the nucleus reticularis teg‐ menti pontis and the medial pontine nucleus. Following 1day survival, single‐ and double‐labeled neurons were examined in the mammillary nuclei.
Following the Money: The Influence of Campaign Finance Reform in the 2011 Chicago Mayoral Election

ABSTRACT: In this research we study the effect of recently enacted campaign contribution limits in Illinois via an examination of the 2011 Chicago mayoral election. Because contribution limits for state and local campaigns were implemented in the middle of the race for mayor we are uniquely positioned to test the efficacy of the new law. In theory we expect contribution limits to cause candidates to rely on more contributors making smaller donations. Our results indicate that the reform measure did not prompt candidates to broaden their fundraising base, and only when Rahm Emanuel’s campaign is considered alongside his opponents’ did the fundraising law reduce average contributions. In a concluding section we address the issue of whether the contribution limits established under the law are too high to produce meaningful reform.
Caries-inhibiting effect of preventive measures during orthodontic treatment with fixed appliances

A systematic review was performed of published data on the caries-inhibiting effect of preventive measures during orthodontic treatment with fixed appliances. The purpose was to develop evidence-based recommendations about the most effective means of preventing white spot lesions in orthodontic patients. The 15 studies included were divided into four groups based on comparable preventive measures: fluoride, chlorhexidine, sealants and bonding materials. The caries-inhibiting effect of the preventive measures was expressed by the prevented fraction (PF). The overall PF of the fluoride-releasing bonding materials was 20% (SEM 0.09). This effect was, however, not statistically significant. It was impossible to calculate an overall PF for the other preventive measures, but the tendency of their caries-inhibiting effect has been described. The use of toothpaste and gel with a high fluoride concentration of 1,500–5,000 ppm or of complementary chlorhexidine during orthodontic treatment showed a demineralisation-inhibiting tendency. The use of a polymeric tooth coating on the tooth surface around the brackets showed almost no demineralisation-inhibiting effect. Many publications had to be excluded from this systematic review because of improper research designs. Future clinical trials are needed to give evidence- based advice on the optimal caries-prevention strategy.
Who Loses HOPE? Attrition from Georgia’s College Scholarship Program

Georgia’s lottery-funded HOPE Scholarship program provides free tuition to in-state students who can maintain a B average at state universities. However, roughly half of HOPE Scholars lose their support after their freshman year. This study employs student-level administrative data to identify the observed characteristics that systematically relate to scholarship attrition. Conditional on measures of student ability, there are not statistically significant differences between white, black, and Hispanic students. However, there are dramatic differences across academic disciplines. Students majoring in science, engineering, and computing are 21 to 51 percent more likely to lose their HOPE Scholarships than students in other disciplines.
Bubbles and Busts: The 1990s in the Mirror of the 1920s

This paper surveys the twentieth century booms and crashes in the American stock market, focusing on a comparison of the two most similar events in the 1920s and 1990s. In both booms, claims were made that they were the consequence a %u201Cnew economy%u201D or %u201Cirrational exuberance. %u201D Neither boom can be readily explained by fundamentals, represented by expected dividend growth or changes in the equity premium. The difficulty of identifying the fundamentals implies that central banks would not be successful in preventing pre-emptive policies, although they still would have a critical role to play in preventing crashes from disrupting the payments system or sparking an intermediation crisis.
Aligning Manufacturing Strategy and Business-Level Competitive Strategy in New Competitive Environments: The Case for Strategic Resonance

In this paper we make the case for strategic resonance in the strategy making process within dynamic and highly volatile market conditions. We discuss how managers are faced with competing paradigms of resource-driven versus market-led approaches to strategy but we suggest that both paradigms have flaws and may cause strategic dissonance to occur. Moreover, we offer additional insights into why strategic dissonance can occur within the strategy process of the firm. We suggest that a key omission often lies in the neglect of operations managers’ potentially important contributions to the strategy mainstream process.
Acute Hormonal Responses to Heavy Resistance Exercise in Men and Women at Different Ages

To examine acute endogenous hormonal responses to heavy resistance exercise eight young women (YW) and eight young men (YM) in the 30-year age group, seven middle-aged women (MW) and eight middle-aged men (MM) in the 50-year age group as well as eight elderly women (EW) and eight elderly men (EM) in the 70-year age group performed a heavy resistance exercise session with three different exercises (bench press, sit-up exercise and bilateral leg press). The relative loading intensity and volume of the exercise session were kept the same for each subject so that they performed each of the 5 sets of each exercise with the maximal load possible for 10 repetitions per set (10 repetition maximum). The recovery time between the sets was 3 minutes. The loading led to acute significant decreases in maximal isometric leg extension force by 19 +/- 7% (p < 0.001), 31 +/- 15% (p < 0.01) and by 14 +/- 12% (p < 0.01) in YW, MW and EW, respectively, and by 24 +/- 16% (p < 0.01), 34 +/- 9% (p < 0.001) and by 20 +/- 12% (p < 0.001) for YM, MM and EM, respectively. The mean concentrations of serum testosterone and cortisol remained statistically unchanged for all female groups. Significant increases took place in testosterone concentrations in YM (p < 0.05) and in MM (p < 0.01) and in cortisol in MM (p < 0.01), while EM demonstrated no change at all. Serum growth hormone (GH) increased in women both in YW from 3.6 +/- 3.4 to 11.7 +/- 8.2 micrograms x l-1 (p < 0.01) and in MW from 0.3 +/- 0.1 to 6.5 +/- 5.6 micrograms x l-1 (p < 0.05), while EW demonstrated no change. In men GH concentrations increased in YM from 0.1 +/- 0.1 to 21.2 +/- 18.1 micrograms x l-1 (p < 0.05) and in MM from 0.3 +/- 0.2 to 6.0 +/- 5.4 micrograms x l-1 (p < 0.05), while EM demonstrated no change. The primary results indicate that the response of GH concentrations to the same relative heavy resistance work load is greatly lowered with increasing age both in men and women, while acute responses in testosterone levels are minor.
Firm Survival and the Evolution of Oligopoly

After their commercial introduction, the number of producers of autos, tires, televisions, and penicillin initially grew and then experienced a sharp decline or shakeout. Guided by an evolutionary model of entry and exit, firm survival patterns in the four products are examined to determine whether there were common forces governing their distinctive evolution. Predictions concerning the effects of pre- and post-entry experience and the timing of entry on firm survival are tested. The findings are used to reflect on why industries experience shakeouts and evolve to be oligopolies.
Decoding the Functional Roles of Cationic Side Chains of the Major Antimicrobial Region of Human Cathelicidin LL-37

ABSTRACT Human cathelicidin LL-37 is a critical cationic antimicrobial peptide for host defense against infection, immune modulation, and wound healing. This article elucidates the functional roles of the cationic side chains of the major antimicrobial region of LL-37, corresponding to residues 17 to 32 (designated GF-17). Antimicrobial assays, killing kinetics studies, and vesicle leakage experiments all indicate that a conversion of lysines to arginines affected the ability of the peptide to kill the Gram-positive Staphylococcus aureus strain USA300. Alanine scanning experiments show that S. aureus is less sensitive than Escherichia coli to a single cationic residue mutation of GF-17. Among the five cationic residues, R23 appears to be somewhat important in killing S. aureus. However, R23 and K25 of GF-17 are of prime importance in killing the Gram-negative organism E. coli. In particular, R23 is essential for (i) rapid recognition, (ii) permeation of the E. coli outer membrane, (iii) clustering of anionic lipids in a membrane system mimicking the E. coli inner membrane, and (iv) membrane disruption. Bacterial aggregation (i.e., rapid recognition via charge neutralization) is the first step of the peptide action. Structurally, R23 is located in the interface (i.e., the first action layer), a situation ideal for the interactions listed above. In contrast, residues K18, R19, and R29 are on the hydrophilic surface of the amphipathic helix and play only a secondary role. Mapping of the functional spectrum of cationic residues of GF-17 provides a solid basis for engineering bacterium-specific antimicrobials using this highly potent template.
Commitment, first-mover-, and second-mover advantage

We identify circumstances under which a firm with a first-mover advantage may get leapfrogged by a follower. At the market stage we assume a Stackelberg structure, i.e. the leader commits to a quantity and the follower reacts to it. We allow the owners of both firms to select the internal organization and the production technology before quantities are set. That is, leader and follower can additionally use two commitment strategies alternatively or in combination: investing in R&D and delegating quantity decisions to managers. Despite the symmetry of options for the two firms, we find that there is a unique equilibrium in which both firms invest in process R&D, only the follower delegates, and the follower can overcome the first-mover advantage of the quantity leader and obtain a higher profit than the leader. Our analysis reveals that there are some important differences between the two commitment devices “cost-reducing R&Dt” and “delegation to managers”.
Animal Spirits in the Euro Area Sovereign CDS Market

We study the determinants for the sovereign credit default swap (CDS) spreads of five Euro-area countries (Greece, Ireland, Italy, Portugal, Spain) in the post-Lehman-Brothers period. We find that there are regime switches in the process of sovereign CDS spread changes. We consider three alternative empirical hypotheses associated with regime switches. Under the first hypothesis, there are rational sunspot equilibria. Under the second hypothesis, there is a unique fundamental equilibrium and the regime switching is caused by changes in policy makers' preferences. The third hypothesis relaxes the rational expectations assumption. Under this hypothesis, indicators of the market fundamentals are not always precise. They are better indicators if cognitive biases are small and the rational expectations economy is a good approximation for reality. However, if market uncertainties enlarge the cognitive biases, the market-based indicators of fundamentals are no longer precise. In this case, they are not useful for CDS pricing. We find that the first two hypotheses are difficult to fit the data and the third hypothesis provides a good explanation for the sovereign CDS spread dynamics in our sample.
The Privatization Decision

In this article, the political environment of privatization and its impact on public management are examined in the context of the privatization of a state park in Georgia. The study specifically focuses on the actions of public managers in the privatization formulation and implementation stage. Public management capacity actually increased as a result of privatization. This is an outcome quite different from those reported by public management studies of other privatized services. Applying a principal-agent framework, this study yielded several lessons that may strengthen public managers’capacity to act as “smart buyers” of goods and services and to enforce accountability when managing contractual relationships. This study links theory to practice using a case study that allows a careful examination of the strategic responses of public managers confronted by largely political, as opposed to economic, pressures to privatize an already successful state park.
Australian foreign policy, human rights in China and the spiral model

In 1997 Australia changed its human rights policy regarding China from its support for resolutions on China at the UN Commission on Human Rights (UNCHR) to the adoption of the bilateral human rights dialogue process. From 1991 to 1997 the UNCHR process had greatly contributed to the Chinese government making human rights concessions such that China could be considered to be in phase three (tactical concessions) of the spiral model of Thomas Risse, Stephen Ropp and Kathryn Sikkink. To progress to phase four (prescriptive status), continued pressures by international and domestic actors are needed so that support and protection is provided to domestic human rights activists. The annual Australia–China bilateral dialogue meetings do not appear to be contributing to those pressures. However, in a limited way given its small scale, the Australia–China Technical Cooperation Program may help to bring about further human rights improvements in China.
Definitive results of a phase III adjuvant trial comparing three chemotherapy regimens in women with operable, node-positive breast cancer: the NSABP B-38 trial.

PURPOSE Anthracycline- and taxane-based three-drug chemotherapy regimens have proven benefit as adjuvant therapy for early-stage breast cancer. This trial (NSABP B-38; Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Positive Breast Cancer) asked whether the incorporation of a fourth drug could improve outcomes relative to two standard regimens and provided a direct comparison of those two regimens. PATIENTS AND METHODS We randomly assigned 4,894 women with node-positive early-stage breast cancer to six cycles of docetaxel, doxorubicin, and cyclophosphamide (TAC), four cycles of dose-dense (DD) doxorubicin and cyclophosphamide followed by four cycles of DD paclitaxel (P; DD AC→P), or DD AC→P with four cycles of gemcitabine (G) added to the DD paclitaxel (DD AC→PG). Primary granulocyte colony-stimulating factor support was required; erythropoiesis-stimulating agents (ESAs) were used at the investigator's discretion. RESULTS There were no significant differences in 5-year disease-free survival (DFS) between DD AC→PG and DD AC→P (80.6% v 82.2%; HR, 1.07; P = .41), between DD AC→PG and TAC (80.6% v 80.1%; HR, 0.93; P = .39), in 5-year overall survival (OS) between DD AC→PG and DD AC→P (90.8% v 89.1%; HR, 0.85; P = .13), between DD AC→PG and TAC (90.8% v 89.6%; HR, 0.86; P = .17), or between DD AC→P versus TAC for DFS (HR, 0.87; P = .07) and OS (HR, 1.01; P = .96). Grade 3 to 4 toxicities for TAC, DD AC→P, and DD AC→PG, respectively, were febrile neutropenia (9%, 3%, 3%; P < .001), sensory neuropathy (< 1%, 7%, 6%; P < .001), and diarrhea (7%, 2%, 2%; P < .001). Exploratory analyses for ESAs showed no association with DFS events (HR, 1.02; P = .95). CONCLUSION Adding G to DD AC→P did not improve outcomes. No significant differences in efficacy were identified between DD AC→P and TAC, although toxicity profiles differed.
Microbiota of Human Breast Tissue

ABSTRACT In recent years, a greater appreciation for the microbes inhabiting human body sites has emerged. In the female mammary gland, milk has been shown to contain bacterial species, ostensibly reaching the ducts from the skin. We decided to investigate whether there is a microbiome within the mammary tissue. Using 16S rRNA sequencing and culture, we analyzed breast tissue from 81 women with and without cancer in Canada and Ireland. A diverse population of bacteria was detected within tissue collected from sites all around the breast in women aged 18 to 90, not all of whom had a history of lactation. The principal phylum was Proteobacteria. The most abundant taxa in the Canadian samples were Bacillus (11.4%), Acinetobacter (10.0%), Enterobacteriaceae (8.3%), Pseudomonas (6.5%), Staphylococcus (6.5%), Propionibacterium (5.8%), Comamonadaceae (5.7%), Gammaproteobacteria (5.0%), and Prevotella (5.0%). In the Irish samples the most abundant taxa were Enterobacteriaceae (30.8%), Staphylococcus (12.7%), Listeria welshimeri (12.1%), Propionibacterium (10.1%), and Pseudomonas (5.3%). None of the subjects had signs or symptoms of infection, but the presence of viable bacteria was confirmed in some samples by culture. The extent to which these organisms play a role in health or disease remains to be determined.
Osteopontin and Calcium Stone Formation

Osteopontin (OPN) is a phosphorylated protein of wide tissue distribution that is found in association with dystrophic calcification including in the organic matrix of kidney stones. It is a strong inhibitor of crystal formation and growth in vitro, but there is still debate regarding its effects upon crystal adhesion to tubular epithelial cells. In this brief review, we will outline the evidence implicating OPN in stone disease with the primary emphasis being on the interaction of OPN with calcium oxalate (CaOx), the major constituent of calcium containing stones. Finally, preliminary data is presented regarding the amounts and features of OPN present in the urine of stone formers and normal individuals.
TNF signalling drives expansion of bone marrow CD4+ T cells responsible for HSC exhaustion in experimental visceral leishmaniasis

Visceral leishmaniasis is associated with significant changes in hematological function but the mechanisms underlying these changes are largely unknown. In contrast to naïve mice, where most long-term hematopoietic stem cells (LT-HSCs; LSK CD150+ CD34- CD48- cells) in bone marrow (BM) are quiescent, we found that during Leishmania donovani infection most LT-HSCs had entered cell cycle. Loss of quiescence correlated with a reduced self-renewal capacity and functional exhaustion, as measured by serial transfer. Quiescent LT-HSCs were maintained in infected RAG2 KO mice, but lost following adoptive transfer of IFNγ-sufficient but not IFNγ-deficient CD4+ T cells. Using mixed BM chimeras, we established that IFNγ and TNF signalling pathways converge at the level of CD4+ T cells. Critically, intrinsic TNF signalling is required for the expansion and/or differentiation of pathogenic IFNγ+CD4+ T cells that promote the irreversible loss of BM function. These findings provide new insights into the pathogenic potential of CD4+ T cells that target hematopoietic function in leishmaniasis and perhaps other infectious diseases where TNF expression and BM dysfunction also occur simultaneously.
Does the Natural-Resource-Based View of the Firm Apply in an Emerging Economy? A Survey of Foreign Invested Enterprises in China

This study explores whether enterprises operating in China benefit from the practice of the tenets of the natural-resource-based view of the firm (NRVF). To this end, a conceptual model is proposed that depicts the major determinants and consequences of the practice of NRVF. By and large, the survey data collected from foreign invested enterprises (FIEs) in China confirm the validity of the proposed model, and suggest that the NRVF is applicable in the world's largest and fastest-growing emerging economy. These results remind FIEs in China of the opportunities to enhance corporate environmental and financial performance through the adoption of environmental strategies. Various regression and multi-group analyses conducted in this study further reveal significant moderating influences of perceived environmental uncertainties, operating mode, and firm size on the process of achieving company-wide ecological sustainability.
Protection of women rights through legal reforms in Pakistan

This paper presents the status of women rights in Pakistan and protection of these rights under the umbrella of legal reforms. After independence the women of Pakistan played an active role in nation building activities as well for their own social uplift. International organizations played special attention towards the issue of women empowerment During Ayub Era Muslim Family Law Ordinance 1961 was promulgated which is regarded as a first step forward for the protection of women rights. During Zia regime discriminatory laws were introduced which disturbed the equilibrium between male and female in the society. These laws put a negative impact on the status of women. Women organizations protested against Hudood Laws and demanded to repeal it. During the period of Musharruf new laws were introduced for the protection of women rights(women Protection Act 2006),it is regarded as golden era in context of legislation made for women empowerment . The process of legal reforms is in progression . The women are still subjugated to many criminal acts like harassment at work place ,attempted rape and acid throwing. There is a need of devising effective implementation mechanism in true letter and spirit for the safeguard of women rights.