Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigation of Sectoral Scanning in Selective Laser Melting

Selective laser melting (SLM), a powder metallurgical (PM) additive manufacturing (AM) technology, is able to produce fully functional parts directly from standard metal powders without using any intermediate binders or any additional post-processing steps. During the process, a laser beam selectively scans a powder bed according to the CAD data of the part to be produced and completely melts the powder particles together. Stacking and bonding two-dimensional powder layers in this way, allows production of fully dense parts with any geometrical complexity. The scanning of the powder bed by the laser beam can be achieved in several different ways, one of which is island or sectoral scanning. In this way, the area to be scanned is divided in small square areas (‘sectors’) which are scanned in a random order. This study is carried out to explore the influence of sectoral scanning on density, surface quality, mechanical properties and residual stresses formed during SLM. The experiments are carried out on a machine with an Nd:YAG laser source using AISI 316L stainless steel powder. As a result of this experimental study, it is concluded that sectoral scanning has some advantages such as lower residual stresses and better surface quality. However, the selection of parameters related to sectoral scanning is a critical task since it may cause aligned porosity at the edges between sectors or scanned tracks, which is very undesired in terms of mechanical properties.Copyright © 2010 by ASME
The Wide-Area Virtual Service Migration Problem: A Competitive Analysis Approach

Today's trend toward network virtualization and software-defined networking enables flexible new distributed systems where resources can be dynamically allocated and migrated to locations where they are most useful. This paper proposes a competitive analysis approach to design and reason about online algorithms that find a good tradeoff between the benefits and costs of a migratable service. A competitive online algorithm provides worst-case performance guarantees under any demand dynamics, and without any information or statistical assumptions on the demand in the future. This is attractive especially in scenarios where the demand is hard to predict and can be subject to unexpected events. As a case study, we describe a service (e.g., an SAP server or a gaming application) that uses network virtualization to improve the quality of service (QoS) experienced by thin client applications running on mobile devices. By decoupling the service from the underlying resource infrastructure, it can be migrated closer to the current client locations while taking into account migration costs. We identify the major cost factors in such a system and formalize the wide-area service migration problem. Our main contributions are a randomized and a deterministic online algorithm that achieve a competitive ratio of O(logn) in a simplified scenario, where n is the size of the substrate network. This is almost optimal. We complement our worst-case analysis with simulations in different specific scenarios and also sketch a migration demonstrator.
A NEW RAYTRACER FOR MODELING AU-SCALE IMAGING OF LINES FROM PROTOPLANETARY DISKS

The material that formed the present-day solar system originated in feeding zones in the inner solar nebula located at distances within ∼20 AU from the Sun, known as the planet-forming zone. Meteoritic and cometary material contain abundant evidence for the presence of a rich and active chemistry in the planet-forming zone during the gas-rich phase of solar system formation. It is a natural conjecture that analogs can be found among the zoo of protoplanetary disks around nearby young stars. The study of the chemistry and dynamics of planet formation requires: (1) tracers of dense gas at 100–1000 K and (2) imaging capabilities of such tracers with 5–100 mas (0.5–20 AU) resolution, corresponding to the planet-forming zone at the distance of the closest star-forming regions. Recognizing that the rich infrared (2–200 μm) molecular spectrum recently discovered to be common in protoplanetary disks represents such a tracer, we present a new general ray-tracing code, RADLite, that is optimized for producing infrared line spectra and images from axisymmetric structures. RADLite can consistently deal with a wide range of velocity gradients, such as those typical for the inner regions of protoplanetary disks. The code is intended as a back-end for chemical and excitation codes, and can rapidly produce spectra of thousands of lines for grids of models for comparison with observations. Such radiative transfer tools will be crucial for constraining both the structure and chemistry of planet-forming regions, including data from current infrared imaging spectrometers and extending to the Atacama Large Millimeter Array and the next generation of Extremely Large Telescopes, the James Webb Space Telescope and beyond.
Presentation of a T Cell Receptor Antagonist Peptide by Immunoglobulins Ablates Activation of  T Cells by a Synthetic Peptide or Proteins Requiring Endocytic Processing

T cell receptor (TCR) antagonism is being considered for inactivation of aggressive T cells and reversal of T cell–mediated autoimmune diseases. TCR antagonist peptides silence aggressive T cells and reverse experimental allergic encephalomyelitis induced with free peptides. However, it is not clear whether free antagonist peptides could reverse natural disease where the antigen is presumably available for endocytic processing and peptides gain access to newly synthesized class II MHC molecules. Using an efficient endocytic presentation system, we demonstrate that a proteolipid protein (PLP) TCR antagonist peptide (PLP-LR) presented on an Ig molecule (IgPLP-LR) abrogates the activation of T cells stimulated with free encephalitogenic PLP peptide (PLP1), native PLP, or an Ig containing PLP1 peptide (Ig-PLP1). Free PLP-LR abolishes T cell activation when the stimulator is free PLP1 peptide, but has no measurable effect when the stimulator is the native PLP or Ig-PLP1. In vivo, Ig-PLP1 induces a T cell response to PLP1 peptide. However, when coadministered with Ig-PLP-LR, the response to PLP1 peptide is markedly reduced whereas the response to PLP-LR is normal. Free PLP-LR coadministered with Ig-PLP1 has no effect on the T cell response to PLP1. These findings indicate that endocytic presentation of an antagonist peptide by Ig outcompete both external and endocytic agonist peptides whereas free antagonist hinders external but not endocytic agonist peptide. Direct contact with antagonist ligand and/or trans-regulation by PLP-LR–specific T cells may be the operative mechanism for Ig-PLP-LR–mediated downregulation of PLP1-specific T cells in vivo. Efficient endocytic presentation of antagonist peptides, which is the fundamental event for either mechanism, may be critical for reversal of spontaneous T cell–mediated autoimmune diseases where incessant endocytic antigen processing could be responsible for T cell aggressivity.
FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

Significance Calcineurin is an essential Ca2+-dependent phosphatase in all eukaryotes. Whether calcineurin can be endogenously regulated by factors other than Ca2+ and calmodulin is not known. Using a model of Parkinson's Disease (PD) as a surrogate for high pathophysiological calcineurin activity and employing a shotgun proteomic approach, we show that the isomerase FKBP12 physiological regulates calcineurin activity by facilitating dephosphorylation of proteins involved in vesicle recycling. Using a rodent model of PD, partial inhibition of the functional interaction between FKBP12 and calcineurin blocks the phosphatase activity toward critical vesicle recycling proteins at nigral presynaptic terminals conferring strong neuroprotection. Our work reassigns to FKBP12 a novel mechanism that supports toxicity in a PD model by modulating calcineurin's phosphatase activity with therapeutic implications. Calcineurin is an essential Ca2+-dependent phosphatase. Increased calcineurin activity is associated with α-synuclein (α-syn) toxicity, a protein implicated in Parkinson’s Disease (PD) and other neurodegenerative diseases. Calcineurin can be inhibited with Tacrolimus through the recruitment and inhibition of the 12-kDa cis-trans proline isomerase FK506-binding protein (FKBP12). Whether calcineurin/FKBP12 represents a native physiologically relevant assembly that occurs in the absence of pharmacological perturbation has remained elusive. We leveraged α-syn as a model to interrogate whether FKBP12 plays a role in regulating calcineurin activity in the absence of Tacrolimus. We show that FKBP12 profoundly affects the calcineurin-dependent phosphoproteome, promoting the dephosphorylation of a subset of proteins that contributes to α-syn toxicity. Using a rat model of PD, partial elimination of the functional interaction between FKBP12 and calcineurin, with low doses of the Food and Drug Administration (FDA)-approved compound Tacrolimus, blocks calcineurin’s activity toward those proteins and protects against the toxic hallmarks of α-syn pathology. Thus, FKBP12 can endogenously regulate calcineurin activity with therapeutic implications for the treatment of PD.
Visualizing Seismic Risk and Uncertainty

Government agencies and other authorities often communicate earthquake risks using maps derived from geographic information systems. Yet, little is known about the effects of these maps on risk perceptions. While mental models research and other approaches are available to inform risk communication text design, similar empirically derived guidance is lacking for visual risk communications, such as maps, which are likely to trump text in their impact and appeal. This paper reviews the empirical research that might inform such guidance. Research on graphs, spatial and visual perception, and map design suggests that graphics increase risk avoidance over numerical risk representations, and countable visuals, like dots, can increase the accuracy of perceived risks, but not always. Cartographic design features, such as color, animation, interactivity, and depth cues, are all candidates to represent risk and uncertainty and to influence risk perception. While there are robust known effects of color (e.g., red = danger), with some cultural variability, animation can increase the salience of otherwise obscure features but is not uniformly effective. Depth cues, dimensionality, and the extent to which a representation depicts versus symbolizes a scene will influence the viewer's perspective and perception, depending on the viewer's familiarity with the scene; their effects on risk perception remain unclear. The translation and representation of technical information about risk and uncertainty is critical to risk communication effectiveness. Our review suggests a handful of candidate criteria for evaluating the effects of risk visualizations, short of changes in behavior: accuracy, accessibility, retention, and perceived risk and usefulness.
Morphological changes in isotactic polypropylene as a function of cooling rate

Abstract A new method for monitoring rather than controling thermal history has been applied recently to analyze the crystallization kinetics at high cooling rate of a highly pure isotactic polypropylene, proving that the cooling history relevant to the structure of quenched samples is in the neighborhood of 90°C. A continuous variation of morphology and crystal structure was obtained with cooling rate. At cooling rates above 20°C/s, mesomorphic and α-monoclinic phases coexist with a morphology characterized by negatively birefringent spherulites surrounded by a weakly birefringent medium; below this value of cooling rate only α-monoclinic phase is formed, composed of mixed spherulites.
In the Era of Systematic Reviews, Does the Size of an Individual Trial Still Matter?

Background to the debate: Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic reviews—and the fact that individual clinical trials rarely provide definitive answers to a clinical research question—some commentators question whether the sample size calculation for an individual trial still matters. Others point out that small trials can still be potentially misleading.
Overlapping humoral autoimmunity links rheumatic fever and the antiphospholipid syndrome.

OBJECTIVE Rheumatic fever (RF) and the antiphospholipid syndrome (APS) are autoimmune diseases that share similar cardiac and neurological pathologies. We assessed the presence of shared epitopes between M protein, N-acetyl-beta-D-glucosamine (GlcNAc) and beta2 glycoprotein-I (beta2GPI), the pathogenic molecules engaged in these autoimmune conditions. METHODS Sera from the APS patients were affinity-purified on beta2GPI and beta2GPI-related peptide columns. Sera from RF patients were affinity-purified on protein G column. The beta2GPI and M protein-related peptides were prepared by conventional solid-phase peptide synthesis. The enzyme-linked immunosorbent assay direct binding and inhibition studies were performed on the RF and APS sera for the presence, and cross-reactivity, of antibodies against beta2GPI, beta2GPI-related peptides, streptococcal M protein, M-derived peptides and GlcNAc. RESULTS Antibodies (Abs) to beta2GPI were found in 24.4% of 90 RF patients. Antibodies against various beta2GPI-related peptides were found in 1.1-36.7% of the patients. The immunoglobulin G sera from RF patients possessed significant anti-beta2GPI activity, while sera from APS patients contained a considerable anti-streptococcal M protein as well as anti-GlcNAc activity. Furthermore, affinity-purified anti-beta2GPI and anti-beta2GPI-related peptide Abs from APS patients cross-reacted with streptococcal M protein and M5 peptide, while beta2GPI and beta2GPI-related peptides inhibited anti-streptococcal M protein activity from RF patients. The results were confirmed by immunoblot analyses. The beta2GPI also inhibited anti-GlcNAc activity from APS patients with chorea. CONCLUSIONS The results of our study, showing a considerable overlap of humoral immunity in RF and APS, support a hypothesis that common pathogenic mechanisms underlie the development of cardiac valve lesions and Central Nervous System abnormalities in both diseases.
Does Uremia Cause Vascular Dysfunction

Vascular dysfunction induced by uremia has 4 main aspects. (1) Atherosclerosis is increased. Intima-media thickness is increased, and animal studies have established that uremia accelerates atherosclerosis. Uremic toxins are involved in several steps of atherosclerosis. Leukocyte activation is stimulated by guanidines, advanced glycation end products (AGE), p-cresyl sulfate, platelet diadenosine polyphosphates, and indoxyl sulfate. Endothelial adhesion molecules are stimulated by indoxyl sulfate. Migration and proliferation of vascular smooth muscle cells (VSMC) are stimulated by local inflammation which could be triggered by indoxyl sulfate and AGE. Uremia is associated with an increase in von Willebrand factor, thrombomodulin, plasminogen activator inhibitor 1, and matrix metalloproteinases. These factors contribute to thrombosis and plaque destabilization. There is also a decrease in nitric oxide (NO) availability, due to asymmetric dimethylarginine (ADMA), AGE, and oxidative stress. Moreover, circulating endothelial microparticles (EMP) are increased in uremia, and inhibit the NO pathway. EMP are induced in vitro by indoxyl sulfate and p-cresyl sulfate. (2) Arterial stiffness occurs due to the loss of compliance of the vascular wall which induces an increase in pulse pressure leading to left ventricular hypertrophy and a decrease in coronary perfusion. Implicated uremic toxins are ADMA, AGE, and oxidative stress. (3) Vascular calcifications are increased in uremia. Their formation involves a transdifferentiation process of VSMC into osteoblast-like cells. Implicated uremic toxins are mainly inorganic phosphate, as well as reactive oxygen species, tumor necrosis factor and leptin. (4) Abnormalities of vascular repair and neointimal hyperplasia are due to VSMC proliferation and lead to severe reduction of vascular lumen. Restenosis after coronary angioplasty is higher in dialysis than in nondialysis patients. Arteriovenous fistula stenosis is the most common cause of thrombosis. Uremic toxins such as indoxyl sulfate and some guanidine compounds inhibit endothelial proliferation and wound repair. Endothelial progenitor cells which contribute to vessel repair are decreased and impaired in uremia, related to high serum levels of β2-microglobulin and indole-3 acetic acid. Overall, there is a link between kidney function and cardiovascular risk, as emphasized by recent meta-analyses. Moreover, an association has been reported between cardiovascular mortality and uremic toxins such as indoxyl sulfate, p-cresol and p-cresyl sulfate.
Nucleation of Fe-rich phosphates and carbonates on microbial cells and exopolymeric substances

Although phosphate and carbonate are important constituents in ancient and modern environments, it is not yet clear their biogeochemical relationships and their mechanisms of formation. Microbially mediated carbonate formation has been widely studied whereas little is known about the formation of phosphate minerals. Here we report that a new bacterial strain, Tessarococcus lapidicaptus, isolated from the subsurface of Rio Tinto basin (Huelva, SW Spain), is capable of precipitating Fe-rich phosphate and carbonate minerals. We observed morphological differences between phosphate and carbonate, which may help us to recognize these minerals in terrestrial and extraterrestrial environments. Finally, considering the scarcity and the unequal distribution and preservation patterns of phosphate and carbonates, respectively, in the geological record and the biomineralization process that produces those minerals, we propose a hypothesis for the lack of Fe-phosphates in natural environments and ancient rocks.
Microservices in Web Objects Enabled IoT Environment for Enhancing Reusability

In the ubiquitous Internet of Things (IoT) environment, reusing objects instead of creating new one has become important in academics and industries. The situation becomes complex due to the availability of a huge number of connected IoT objects, and each individual service creates a new object instead of reusing the existing one to fulfill a requirement. A well-standard mechanism not only improves the reusability of objects but also improves service modularity and extensibility, and reduces cost. Web Objects enabled IoT environment applies the principle of reusability of objects in multiple IoT application domains through central objects repository and microservices. To reuse objects with microservices and to maintain a relationship with them, this study presents an architecture of Web of Objects platform. In the case of a similar request for an object, the already instantiated object that exists in the same or from other domain can be reused. Reuse of objects through microservices avoids duplications, and reduces time to search and instantiate them from their registries. Further, this article presents an algorithm for microservices and related objects discovery that considers the reusability of objects through the central objects repository. To support the reusability of objects, the necessary algorithm for objects matching is also presented. To realize the reusability of objects in Web Objects enabled IoT environment, a prototype has been designed and implemented based on a use case scenario. Finally, the results of the prototype have been analyzed and discussed to validate the proposed approach.
Fatigue assessment of high-frequency mechanical impact (HFMI)-treated welded joints subjected to high mean stresses and spectrum loading

The fatigue strength of welded joints can be improved with various post-weld treatment methods. High-frequency mechanical impact treatment is a residual stress modification technique that creates compressive residual stresses at the weld toe. However, these beneficial residual stresses may relax under certain loading conditions. In this paper, previously published fatigue data for butt and fillet welded joints subjected to high stress ratios and variable amplitude cyclic stresses were evaluated in relation to the current International Institute of Welding (IIW) recommendations on fatigue strength improvement and a proposed IIW design guideline for high-frequency mechanical impact-treated welded joints. The evaluation showed that the current IIW recommendations resulted in both non-conservative and overly conservative fatigue strength estimations depending on the applied stress level, whereas the proposed fatigue assessment guideline fitted the current data well.
Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936

Alzheimer's disease patients have deficits in specific cognitive domains, and susceptibility genes for this disease may influence human cognition in nondemented individuals. To evaluate the role of Alzheimer's disease-linked genetic variation on cognition and normal cognitive ageing, we investigated two Scottish cohorts for which assessments in major cognitive domains are available: the Lothian Birth Cohort of 1921 and the Lothian Birth Cohort of 1936, consisting of 505 and 998 individuals, respectively. 158 SNPs from eleven genes were evaluated. Single SNP analyses did not reveal any statistical association after correction for multiple testing. One haplotype from TRAPPC6A was associated with nonverbal reasoning in both cohorts and combined data sets. This haplotype explains a small proportion of the phenotypic variability (1.8%). These findings warrant further investigation as biological modifiers of cognitive ageing.
Hepatitis C virus infection in patients with hemophilia in Isfahan, Iran

Objectives: Patients with hereditary bleeding disorders are at risk of viral infection such as hepatitis C due to frequent transfusion of blood and blood products. This study aimed to determine the prevalence of hepatitis C and associated risk factors in hemophilic patients in Isfahan, the second big province in Iran. Methods: In a descriptive study, patients with hemophilia in Isfahan province were enrolled. A questionnaire, including demographic and risk factors of hepatitis C was completed through a structured interview with closed questions by a trained interviewer for each patient and HCV-Ab test results were extracted from patient records. Results: In this study, 232 of 350 patients with hemophilia A and B (66%) were positive for hepatitis C. Based on Multivariate Logistic Regression model, no independent risk factor was found. Conclusions: Prevalence of hepatitis C in patients with haemophilia A and B in Isfahan is high. Since no independent risk factor for hepatitis C disease was found in this high risk group, it can be concluded that multitransfusion is the only predictor for hepatitis C.