Miracle-dz/UniFAR-FTUs huggingface dataset:
Transition to First-Year University: Patterns of Change in Adjustment Across Life Domains and Time

The purpose of this prospective study was to (1) monitor the change in adjustment across time and life domains and (2) identify the resources predictive of short- and long-term adjustment to the university transition. A sample of 68 first-year students reported on events, resources, and well-being at four times across the year. Coping and appraisal were evaluated specifically in relation to three life domains (e.g., academic). Results showed that this transition represents a relatively acute stressor, evidencing the greatest strain for students and the largest impact on their well-being on entry. As time passed, students experienced steady improvement in most aspects of adjustment. Results also suggested that women, despite having more resources, may have greater vulnerability to this transition. Finally, the importance of a specific resource to the prediction of well-being depended on the measure of well-being assessed, the specific life domain addressed, the time of assessment, and whether or not concom.
Mortality Risk among Children Admitted in a Large-Scale Nutritional Program in Niger, 2006

Background In 2006, the Médecins sans Frontières nutritional program in the region of Maradi (Niger) included 68,001 children 6–59 months of age with either moderate or severe malnutrition, according to the NCHS reference (weight-for-height<80% of the NCHS median, and/or mid-upper arm circumference<110 mm for children taller than 65 cm and/or presence of bipedal edema). Our objective was to identify baseline risk factors for death among children diagnosed with severe malnutrition using the newly introduced WHO growth standards. As the release of WHO growth standards changed the definition of severe malnutrition, which now includes many children formerly identified as moderately malnourished with the NCHS reference, studying this new category of children is crucial. Methodology Program monitoring data were collected from the medical records of all children admitted in the program. Data included age, sex, height, weight, MUAC, clinical signs on admission including edema, and type of discharge (recovery, death, and default/loss to follow up). Additional data included results of a malaria rapid diagnostic test due to Plasmodium falciparum (Paracheck®) and whether the child was a resident of the region of Maradi or came from bordering Nigeria to seek treatment. Multivariate logistic regression was performed on a subset of 27,687 children meeting the new WHO growth standards criteria for severe malnutrition (weight-for-height<−3 Z score, mid-upper arm circumference<110 mm for children taller than 65 cm or presence of bipedal edema). We explored two different models: one with only basic anthropometric data and a second model that included perfunctory clinical signs. Principal Findings In the first model including only weight, height, sex and presence of edema, the risk factors retained were the weight/height1.84 ratio (OR: 5,774; 95% CI: [2,284; 14,594]) and presence of edema (7.51 [5.12; 11.0]). A second model, taking into account supplementary data from perfunctory clinical examination, identified other risk factors for death: apathy (9.71 [6.92; 13.6]), pallor (2.25 [1.25; 4.05]), anorexia (1.89 [1.35; 2.66]), fever>38.5°C (1.83 [1.25; 2.69]), and age below 1 year (1.42 [1.01; 1.99]). Conclusions Although clinicians will continue to perform screening using clinical signs and anthropometry, these risk indicators may provide additional criteria for the assessment of absolute and relative risk of death. Better appraisal of the child's risk of death may help orientate the child towards either hospitalization or ambulatory care. As the transition from the NCHS growth reference to the WHO standards will increase the number of children classified as severely malnourished, further studies should explore means to identify children at highest risk of death within this group using simple and standardized indicators.
A Raman Spectroscopic Study of Cell Response to Clinical Doses of Ionizing Radiation

The drive toward personalized radiation therapy (RT) has created significant interest in determining patient-specific tumor and normal tissue responses to radiation. Raman spectroscopy (RS) is a non-invasive and label-free technique that can detect radiation response through assessment of radiation-induced biochemical changes in tumor cells. In the current study, single-cell RS identified specific radiation-induced responses in four human epithelial tumor cell lines: lung (H460), breast (MCF-7, MDA-MB-231), and prostate (LNCaP), following exposure to clinical doses of radiation (2–10 Gy). At low radiation doses (2 Gy), H460 and MCF-7 cell lines showed an increase in glycogen-related spectral features, and the LNCaP cell line showed a membrane phospholipid-related radiation response. In these cell lines, only spectral information from populations receiving 10 Gy or less was required to identify radiation-related features using principal component analysis (PCA). In contrast, the MDA-MB-231 cell line showed a significant increase in protein relative to nucleic acid and lipid spectral features at doses of 6 Gy or higher, and high-dose information (30, 50 Gy) was required for PCA to identify this biological response. The biochemical nature of the radiation-related changes occurring in cells exposed to clinical doses was found to segregate by status of p53 and radiation sensitivity. Furthermore, the utility of RS to identify a biological response in human tumor cells exposed to therapeutic doses of radiation was found to be governed by the extent of the biochemical changes induced by a radiation response and is therefore cell line specific. The results of this study demonstrate the utility and effectiveness of single-cell RS to identify and measure biological responses in tumor cells exposed to standard radiotherapy doses.
Female Barbary macaque (Macaca sylvanus) copulation calls do not reveal the fertile phase but influence mating outcome

In a number of primate species, females utter loud and distinctive calls during mating. Here we aim to clarify the information content and function of Barbary macaque (Macaca sylvanus) copulation calls by testing (i) whether or not copulation calls advertise the female fertile phase and (ii) whether and how copulation calls influence male ejaculatory behaviour. In order to do this, we combined hormone measurements with acoustic analysis and behavioural observations. In contrast to a previous study implying that the structure of copulation calls indicates the timing of the fertile phase, our results, using objective endocrine criteria for assessing ovulation, provide evidence that the structure of copulation calls of female Barbary macaques does not reveal the timing of the fertile phase. More importantly, females seem to influence the likelihood of ejaculation by calling versus remaining silent and by adjusting the timing of call onset. Females make use of this ability to influence mating outcome to ensure ejaculatory matings with almost all males in the group. In addition, calls given during ejaculatory copulations differ from those during non-ejaculatory copulations, providing information about mating outcome for listeners. We conclude that in this species, copulation calls apparently serve to enhance sperm competition and maximize paternity confusion.
Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor

Background Increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile is 2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide (Flu-AM1). These activities are shown by Flu-AM1 racemate, but it is not known whether its two single enantiomers behave differently, as is the case towards COX-2 for the parent flurbiprofen enantiomers. Further, the effects of the compound upon COX-2-derived lipids in intact cells are not known. Methodology/Principal Findings COX inhibition was determined using an oxygraphic method with arachidonic acid and 2-arachidonoylglycerol (2-AG) as substrates. FAAH was assayed in mouse brain homogenates using anandamide (AEA) as substrate. Lipidomic analysis was conducted in unstimulated and lipopolysaccharide + interferon γ- stimulated RAW 264.7 macrophage cells. Both enantiomers inhibited COX-2 in a substrate-selective and time-dependent manner, with IC50 values in the absence of a preincubation phase of: (R)-Flu-AM1, COX-1 (arachidonic acid) 6 μM; COX-2 (arachidonic acid) 20 μM; COX-2 (2-AG) 1 μM; (S)-Flu-AM1, COX-1 (arachidonic acid) 3 μM; COX-2 (arachidonic acid) 10 μM; COX-2 (2-AG) 0.7 μM. The compounds showed no enantiomeric selectivity in their FAAH inhibitory properties. (R)-Flu-AM1 (10 μM) greatly inhibited the production of prostaglandin D2 and E2 in both unstimulated and lipopolysaccharide + interferon γ- stimulated RAW 264.7 macrophage cells. Levels of 2-AG were not affected either by (R)-Flu-AM1 or by 10 μM flurbiprofen, either alone or in combination with the FAAH inhibitor URB597 (1 μM). Conclusions/Significance Both enantiomers of Flu-AM1 are more potent inhibitors of 2-AG compared to arachidonic acid oxygenation by COX-2. Inhibition of COX in lipopolysaccharide + interferon γ- stimulated RAW 264.7 cells is insufficient to affect 2-AG levels despite the large induction of COX-2 produced by this treatment.
Incorporating environmental knowledge into Bayesian filtering using attractor functions

Many automotive systems use linear approaches to track and predict other traffic participants. While this may be appropriate on highways, linear predictions do not work properly on curved roads or lane crossings. This contribution introduces a generic way for including environmental knowledge - such as the lane trajectory ahead - to anticipate yaw rate and acceleration of other traffic participants. The anticipatory knowledge is used to improve prediction in filtering tasks. It is embedded in a Bayesian framework by introducing attractors, which modify the probabilistic propagation of state estimations. The attractors model how traffic participants typically behave, given environmental knowledge such as lane information, traffic lights, or indicator lights. We demonstrate the potential of this approach by modeling the fact that vehicles usually stay in their lane. We show that given correct context information and nonlinear traffic situations, the tracking error is considerably lower compared to conventional tracking methods. In addition, we also show that the intentions of other traffic participants may be inferred by comparing actual sensory data with anticipated probability distributions, which were generated dependent on alternative attractors.
Convergence of Iterative Quadratic Programming for Robust Fixed-Endpoint Transfer of Bilinear Systems

We present a computational method for open-loop minimum-norm control synthesis for fixed-endpoint transfer of bilinear ensemble systems that are indexed by two continuously varying parameters. We suppose that one ensemble parameter scales the homogeneous, linear part of the dynamics, and the second parameter scales the effect of the applied control inputs on the inhomogeneous, bilinear dynamics. This class of dynamical systems is motivated by robust quantum control pulse synthesis, where the ensemble parameters correspond to uncertainty in the free Hamiltonian and inhomogeneity in the control Hamiltonian, respectively. Our computational method is based on polynomial approximation of the ensemble state in parameter space and discretization of the evolution equations in the time domain using a product of matrix exponentials corresponding to zero-order hold controls over the time intervals. The dynamics are successively linearized about control and trajectory iterates to formulate a sequence of quadratic programs for computing perturbations to the control that successively improve the objective until the iteration converges. We use a two-stage computation to first ensure transfer to the desired terminal state, and then minimize the norm of the control function. The method is demonstrated for the canonical uniform transfer problem for the Bloch system that appears in nuclear magnetic resonance, as well as the matter-wave splitting problem for the Raman-Nath system that appears in ultra-cold atom interferometry.
Applications to Social Work Programmes in England: Students as Consumers?

One of the most resounding impacts of the introduction of the new social work degree in England in 2003 has been an increase in the number of applications to social work courses. However, the processes used by applicants to reach decisions about where to study social work are little understood. This article reports data from six preparatory focus groups and four interviews (n = 38), 17 focus group interviews with first year students (n = 112) from nine social work programmes run in six universities, and 2,606 responses to three online surveys administered to first year students, which were collected as part of the national Evaluation of the New Social Work Degree in England funded by the Department of Health. They show that students use a range of sources to find out about social work education, with rising reliance on electronic media as an information resource. Although the majority cites convenience of location as the chief reason for selecting a particular university, academic reputation appears to be growing in importance. Observations from these data are discussed in the context of consumer behaviour in higher education and in social work education at a time when universities are developing marketing strategies to compete for students.
Glomerulopathy Induced by Immunization with a Peptide Derived from the Goodpasture Antigen α3IV-NC1

Mouse experimental autoimmune glomerulonephritis, a model of human antiglomerular basement membrane disease, depends on both Ab and T cell responses to the Goodpasture Ag noncollagenous domain 1 of the α3-chain of type IV collagen (α3IV-NC1). The aim of our study was to further characterize the T cell–mediated immune response. Repeated immunization with mouse α3IV-NC1 caused fatal glomerulonephritis in DBA/1 mice. Although two immunizations were sufficient to generate high α3IV-NC1–specific IgG titers, Ab and complement deposition along the glomerular basement membranes, and a nephrotic syndrome, two additional immunizations were needed to induce a necrotizing/crescentic glomerulonephritis. Ten days after the first immunization, α3IV-NC1–specific CD4+ cells producing TNF-α, IFN-γ, or IL-17A were detected in the spleen. With the emergence of necrotizing/crescentic glomerulonephritis, ∼0.15% of renal CD4+ cells were specific for α3IV-NC1. Using peptides spanning the whole α3IV-NC1 domain, three immunodominant T cell epitopes were identified. Immunization with these peptides did not lead to clinical signs of experimental autoimmune glomerulonephritis or necrotizing/crescentic glomerulonephritis. However, mice immunized with one of the peptides (STVKAGDLEKIISRC) developed circulating Abs against mouse α3IV-NC1 first detected at 8 wk, and 50% of the mice showed mild proteinuria at 18–24 wk due to membranous glomerulopathy. Taken together, our results suggest that autoreactive T cells are able to induce the formation of pathologic autoantibodies. The quality and quantity of α3IV-NC1–specific Ab and T cell responses are critical for the phenotype of the glomerulonephritis.
Relevant cycles in Chemical reaction Networks

We characterize the distributions of short cycles in a large metabolic network previously shown to have small world characteristics and a power law degree distribution. Compared with three classes of random networks, including Erdős–Renyi random graphs and synthetic small world networks of the same connectivity, both the metabolic network and models for the chemical reaction networks of planetary atmospheres have a particularly large number of triangles and a deficit in large cycles. Short cycles reduce the length of detours when a connection is clipped, so we propose that long cycles in metabolism may have been selected against in order to shorten transition times and reduce the likelihood of oscillations in response to external perturbations.
Prolidase activity and oxidative status in patients with thalassemia major

Aim: Prolidase is a specific imidodipeptidase involved in collagen degradation. The increase in the enzyme activity is believed to be correlated with the increased intensity of collagen degradation. The study aimed to evaluate the relationship between prolidase activity and oxidative status in patients with thalassemia major. Methods: Comparison was made between 87 patients diagnosed with thalassemia major and 33 healthy children of similar age and gender. Mean age of the subjects was 7.5±4.3 years in the group of patients with thalassemia major and 8.9±3.1 years in the control group. Serum prolidase activity was measured spectrophotometrically. Oxidative status was determined using total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurement. Results: Prolidase activity was significantly increased in patients with thalassemia major (53.7±8.7 U/l) compared to the control group (49.2±7.2 U/l, P<0.001). TOS was significantly increased in the patient group (5.31±3.14 mmol H2O2 equiv./l) compared to the control group (3.49±2.98 μmol H2O2 equiv./l) and the OSI was also significantly increased in the patient group (3.86±3.28 arbitrary unit) compared to the control group (2.53±2.70 arbitrary unit) (P<0.0001 and P<0.001, respectively), while there were no significant differences between the patient (1.61±0.30 μmol Trolox equiv./l) and control (1.64±0.33 μmol Trolox equiv./l) groups with respect to TAC. Conclusion: Significant increases in prolidase activity in patients with thalassemia major may constitute a key parameter in demonstrating a disorder of the collagen metabolism. J. Clin. Lab. Anal. 24:6–11, 2010. © 2010 Wiley‐Liss, Inc.
Evolutionary Psychology and Family Business: A New Synthesis for Theory, Research, and Practice

The article seeks to show that the ideas of evolutionary psychology have not only a unique contribution to make to the study of family business but have an overarching capacity to integrate theory, resolve empirical debates, and lead research in new directions. The article considers, first, what is different about family firms before outlining the Darwinian framework and its implications, and then moves on to an analysis of kinship dynamics as central to understanding the roots of cooperation and conflict in the family firm. The article concludes with a discussion of the scope for theoretical synthesis, practical implications, and the position this analysis leads us to about the unique performance potential and liabilities of the family firm.
Unaltered phenotype, tissue distribution and function of Vα14+ NKT cells in germ‐free mice

The expression pattern of mouse CD1d and the tissue distribution of CD1d‐restricted Vα14‐Jα281 NKT cells suggest that the liver and the marginal zone of the spleen might be preferred sites of activation of this potent innate pathway of early cytokine secretion. Because these tissues are particularly involved with the filtration of blood‐borne pathogens, and because NKT cells with an activated / memory phenotype accumulate over the first weeks of life and their CD1 ligands bind microbial glycolipids, it has been hypothesized that expansion of the NKT cell subset may be driven by exposure to the microbial environment. To test this hypothesis, we analyzed the frequency, surface phenotype and functional properties of NKT cells in normal and in germ‐free C57BL / 6 mice. Surprisingly, we found that the NKT cell subset develops in the presence or absence of a microbial environment. Although these results do not rule out the possibility that NKT cells exert a protective function against some microbial agents, they demonstrate that non microbial ligands, possibly self‐antigens are sufficient for the generation, maturation and peripheral accumulation of NKT cells.
'Interaction' Versus 'Action' in Luhmann's Sociology of Communication

Both "actions" and "interactions' can be considered as micro-operations that can be aggregated from a systemic perspective. Whereas actions operate historically, interactions provide the events retrospectively with meaning. Luhmann’s sociology of communication systems adds to the approach of symbolic interactionism the question of what global dimensions of communication mean for local interactions. When communication is functionally differentiated — for example, in terms of media — tensions can be expected to develop between local organizations and global developments of communication structures. Interfaces enable us to translate selectively among (provisionally) stabilized representations, for example, in professional practices. "Big science" and "high tech" can be considered as organizational acculturations of an emerging level of sophistication in global communications. The global dimension remains a hypothesis, but entertaining this hypothesis of "globalization" restructures the local expectations.
Development and Initial Validation of the Narcissistic Personality Questionnaire for Children: A preliminary investigation using school‐based Asian samples

The Narcissistic Personality Questionnaire for Children (NPQC) is a brief self‐report scale for measuring narcissism in children. In Study 1, a factor analysis on 370 children’s NPQC scores revealed four factors that were labeled superiority, exploitativeness, self‐absorption, and leadership. Study 2 established convergent and discriminant validities of the NPQC. NPQC scores were positively correlated with need for power/dominance, self‐esteem, aggression, and need for achievement, and unrelated to life satisfaction, as expected. Further support for the validity of the NPQC was obtained when findings were consistent with attachment theory’s interpretation of narcissistic children’s self‐perceptions. Study 3 investigated the temporal stability of scores. Results from Studies 1 and 3 show the NPQC to be an internally consistent measure (Cronbach alpha = .81) and to have adequate test–retest reliability (r = .81). Implications for the education of aggressive and narcissistic children are discussed.
Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection

Legionella pneumophila, a parasite of macrophages and protozoa, requires iron for optimal extracellular and intracellular growth. However, its mechanisms of iron acquisition remain uncharacterized. Using mini-Tn10 mutagenesis, we isolated 17 unique L. pneumophila strains which appeared to be defective for iron acquisition and assimilation. Eleven of these mutants were both sensitive to the iron chelator ethylenediamine di(o-hydroxyphenylacetic acid) and resistant to streptonigrin, an antibiotic whose lethal effect requires high levels of intracellular iron. Six mutants were also defective for the infection of macrophage-like U937 cells. Although none were altered in entry, mutants generally exhibited prolonged lag phases and in some cases replicated at slower rates. Overall, the reduced recoveries of mutants, relative to that of the wild type, ranged from 3- to 1,000-fold. Strain NU216, the mutant displaying the most severe lag phase and the slowest rate of replication, was studied further. Importantly, within U937 cells, NU216 was approximately 100-fold more sensitive than the wild type was to treatment with the Fe3+ chelator deferoxamine, indicating that it is defective for intracellular iron acquisition and assimilation. Furthermore, this strain was unable to mediate any cytopathic effect and was impaired for infectivity of an amoebal host. Taken together, the isolation of these mutants offers genetic proof that iron acquisition and assimilation are critical for intracellular infection by L. pneumophila.