Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk factors for breast cancer in Brazil.

Sir—In a recent article by Gomes et al} they report the findings of a case-control study of risk factors for breast cancer in Brazil. They conclude that potential risk factors behave in the same way as demonstrated in the rest of the world and that the study provides clear documentation of 'breast cancer epidemiology' (p. 292) in Brazil. We would like to highlight some apparent oversights by the authors and to draw attention to the analytical complexities of breast cancer research especially when reproductive risk factors are being evaluated. They mention that Brazil shows an apparent contrast in that the breast cancer rates are relatively high in comparison with their Latin American neighbours. Previous research on breast cancer had already indicated the importance of conducting studies in Brazil because of such contrasts, which, if classified, could lead to a better understanding of breast cancer. However, they erroneously state that the study 'represents the first large hospital-based, case control study of risk factors for breast cancer conducted in Brazil' (p. 294). ' Two other studies on breast cancer in Brazil have been published, the first in the early 1970s. The second relates to a case-control study on risk factors for breast cancer, and was undertaken in the early 1980s in Recife and Forteleza, two large cities of Northeast Brazil. The cases were breast cancer patients admitted to any of the several hospitals which deal with breast cancer in these two cities, to whom hospital and community matched controls were assigned. This study was larger than that of Gomes et al} and used interview based questionnaires instead of medical records. Results have subsequently been published. These results, presented by Kalache et al. suggested that age at last Full-Term Pregnancy (FTP) was an independent risk factor for breast cancer. This challenged the view that age at first FTP was the principal reproductive risk factor for breast cancer. The close similarity to the findings of a very different study, namely that of a large
The Rise and Fall of Frequency and Imageability: Noun and Verb Production in Semantic Dementia

This study examines the impact of progressive degeneration of conceptual knowledge on the content words used in connected speech elicited using the Cookie Theft picture description (Goodglass & Kaplan. 1983). We began with an analysis of control subjects' descriptions with regard to word types and their frequency and imageability. Because the impairment of conceptual knowledge in semantic dementia is graded by concept familiarity, we created a model of a standardized normal Cookie Theft description that was then progressively degraded by the systematic removal of lower bands of word frequency. We drew two main predictions from this model: reduced availability of the lower bands of word frequency should result in (a) an apparent deficit for noun retrieval in relation to verb retrieval and (b) an apparent reverse imageability effect. Results from a longitudinal study. in which three patients with semantic dementia each described the Cookie Theft picture on three occasions during the progression of their disease, confirmed these predictions. An additional cross-sectional analysis, adding narratives from a larger number of cases, demonstrated that the decline in ability to produce suitable words for the picture description is closely related to the extent of semantic impairment as measured in tests of word comprehension and production. Both verbs and nouns are affected by the degradation of semantic memory; the fact that the impairment to noun production is manifested earlier and more catastrophically may be attributed to the relatively lower frequency of these terms.
Signed Words in the Congenitally Deaf Evoke Typical Late Lexicosemantic Responses with No Early Visual Responses in Left Superior Temporal Cortex

Congenitally deaf individuals receive little or no auditory input, and when raised by deaf parents, they acquire sign as their native and primary language. We asked two questions regarding how the deaf brain in humans adapts to sensory deprivation: (1) is meaning extracted and integrated from signs using the same classical left hemisphere frontotemporal network used for speech in hearing individuals, and (2) in deafness, is superior temporal cortex encompassing primary and secondary auditory regions reorganized to receive and process visual sensory information at short latencies? Using MEG constrained by individual cortical anatomy obtained with MRI, we examined an early time window associated with sensory processing and a late time window associated with lexicosemantic integration. We found that sign in deaf individuals and speech in hearing individuals activate a highly similar left frontotemporal network (including superior temporal regions surrounding auditory cortex) during lexicosemantic processing, but only speech in hearing individuals activates auditory regions during sensory processing. Thus, neural systems dedicated to processing high-level linguistic information are used for processing language regardless of modality or hearing status, and we do not find evidence for rewiring of afferent connections from visual systems to auditory cortex.
Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease

Background: Patients with chronic obstructive pulmonary disease (COPD) often present with severe acute exacerbations requiring hospital treatment. However, little is known about the prognostic consequences of these exacerbations. A study was undertaken to investigate whether severe acute exacerbations of COPD exert a direct effect on mortality. Methods: Multivariate techniques were used to analyse the prognostic influence of acute exacerbations of COPD treated in hospital (visits to the emergency service and admissions), patient age, smoking, body mass index, co-morbidity, long term oxygen therapy, forced spirometric parameters, and arterial blood gas tensions in a prospective cohort of 304 men with COPD followed up for 5 years. The mean (SD) age of the patients was 71 (9) years and forced expiratory volume in 1 second was 46 (17)%. Results: Only older age (hazard ratio (HR) 5.28, 95% CI 1.75 to 15.93), arterial carbon dioxide tension (HR 1.07, 95% CI 1.02 to 1.12), and acute exacerbations of COPD were found to be independent indicators of a poor prognosis. The patients with the greatest mortality risk were those with three or more acute COPD exacerbations (HR 4.13, 95% CI 1.80 to 9.41). Conclusions: This study shows for the first time that severe acute exacerbations of COPD have an independent negative impact on patient prognosis. Mortality increases with the frequency of severe exacerbations, particularly if these require admission to hospital.
Osteoporosis and Anterior Femoral Notching in Periprosthetic Supracondylar Femoral Fractures: A Biomechanical Analysis

Background: This biomechanical study was designed to evaluate the predictive ability of dual-energy x-ray absorptiometry, cortical bone geometry as determined with computed tomography, and radiography in the assessment of torsional load to failure in femora with and without notching.Methods: Thirteen matched pairs of cadaveric femora were randomized into two groups: a notched group, which consisted of femora with a 3-mm anterior cortical defect, and an unnotched group of controls. Each pair then underwent torsional load to failure. The ability of a number of measures to predict femoral torsional load to failure was assessed with use of regression analysis. These measures included dual-energy x-ray absorptiometry scans of the proximal and the distal part of the femur, geometric measures of both anterior and posterior cortical thickness as well as the polar moment of inertia of the distal part of the femur as calculated on computed tomography scans, and the Singh osteoporosis index as determined on radiographs.Results: The torsional load to failure averaged 98.9 N-m for the notched femora and 143.9 N-m for the controls; the difference was significant (p < 0.01). Although several variables correlated with torsional load to failure, distal femoral bone-mineral density demonstrated the highest significant correlation (r = 0.85; p < 0.001). Moreover, multiple regression analysis showed that a combination of distal femoral bone-mineral density and polar moment of inertia calculated with the posterior cortical thickness (adjusted r 2 = 0.79; p < 0.001) had the strongest prediction of torsional load to failure in the notched group. The addition of other measures of cortical bone geometry, proximal femoral bone-mineral density, or radiographic evidence of osteopenia did not significantly increase the model's predictive ability.Conclusions: Femoral notching significantly decreases distal femoral torsional load to failure and is best predicted by a combination of the measures of distal femoral bone-mineral density and polar moment of inertia. Together, these values account for the amount of bone mass present and the stability provided by the cortical shell architecture.Clinical Relevance: Femoral notching during total knee arthroplasty decreases distal femoral torsional load to failure. By examination of femoral bone density and distal femoral geometry, the relative decrease in torsional load to failure can be predicted and appropriate precautions taken.
Viral vectors as tools to model and treat neurodegenerative disorders

The identification of disease‐causing genes in familial forms of neurodegenerative disorders and the development of genetic models closely replicating human central nervous system (CNS) pathologies have drastically changed our understanding of the molecular events leading to neuronal cell death. If these achievements open new opportunities of therapeutic interventions, including gene‐based therapies, the presence of the blood‐brain barrier and the post‐mitotic and poor regenerative nature of the target cells constitute important challenges. Efficient delivery systems taking into account the specificity of the CNS are required to administer potential therapeutic candidates. In addition, genetic models in large animals that replicate the late stages of the diseases are in most cases not available for pre‐clinical studies. The present review summarizes the potential of viral vectors as tools to create new genetic models of CNS disorders in various species including primates and the recent progress toward viral gene therapy clinical trials for the administration of therapeutic candidates into the brain. Copyright © 2005 John Wiley & Sons, Ltd.
Rotationally modulated X-ray emission from T Tauri stars

We have modelled the rotational modulation of X-ray emission from T Tauri stars assuming that they have isothermal, magnetically confined coronae. By extrapolating surface magnetograms, we find that T Tauri coronae are compact and clumpy, such that rotational modulation arises from X-ray emitting regions being eclipsed as the star rotates. Emitting regions are close to the stellar surface and inhomogeneously distributed about the star. However, some regions of the stellar surface, which contain wind bearing open field lines, are dark in X-rays. From simulated X-ray light curves, obtained using stellar parameters from the Chandra Orion Ultradeep Project, we calculate X-ray periods and make comparisons with optically determined rotation periods. We find that X-ray periods are typically equal to, or are half of, the optical periods. Further, we find that X-ray periods are dependent upon the stellar inclination, but that the ratio of X-ray to optical period is independent of stellar mass and radius.
Characterization and outcomes of urethroplasty for hypospadias-associated urethral strictures in adults.

INTRODUCTION Urethral stricture is one of the most commonly encountered complications after hypospadias repair but remains poorly described. The aim of this study is to better characterize hypospadias-associated urethral strictures (HAUS) and treatment outcomes. METHODS We conducted a retrospective analysis of 84 patients who underwent urethroplasty (UP) for HAUS from 2003-2017. Patients were characterized with regard to demographics, stricture length, location, concurrent pathology, previous surgery, type of urethroplasty, 90-day complications, and surgical success defined as the absence of stricture on cystoscopy. Univariate and survival multivariate analysis was performed. RESULTS Overall success was 88.1% at a mean followup of 19 months, with a 90-day complication rate of 9.5%, a 21.4% rate of urethrocutaneous fistula requiring a mean of 1.4 surgeries. Patients were categorized into one of four groups based on stricture length, location, and number of previous procedures: group 1 (66.7%) - previous failed hypospadias repair (HR) with stricture involving the entire repair; group 2 (7.1%) - "junctional stricture" at the junction of the "neourethra" and native urethra; group 3 (11.9%) - isolated bulbar stricture outside the repaired urethra; group 4 (14.3%) - urethral stricture in untreated hypospadias. Despite differing by technique (p<0.0001), stricture length (p=0.02), location (p<0.001), and number of previous repairs (p<0.001), groups did not significantly differ by success (p=0.82), complications (p=0.16), or urethrocutaneous fistula (p=0.19), whereas individual techniques did. CONCLUSIONS UP for HAUS is often successful but patients frequently require more than one operation and have a significant risk of associated complications. Despite a broad spectrum of presentation, patients can often be categorized into one of four groups, which can help direct decision-making and obtain similar outcomes regardless of baseline differences.
Responses of Arthropods to Large-Scale Manipulations of Dead Wood in Loblolly Pine Stands of the Southeastern United States

ABSTRACT Large-scale experimental manipulations of dead wood are needed to better understand its importance to animal communities in managed forests. In this experiment, we compared the abundance, species richness, diversity, and composition of arthropods in 9.3-ha plots in which either (1) all coarse woody debris was removed, (2) a large number of logs were added, (3) a large number of snags were added, or (4) no coarse woody debris was added or removed. The target taxa were ground-dwelling arthropods, sampled by pitfall traps, and saproxylic beetles (i.e., dependent on dead wood), sampled by flight intercept traps and emergence traps. There were no differences in total ground-dwelling arthropod abundance, richness, diversity, or composition among treatments. Only the results for ground beetles (Carabidae), which were more species rich and diverse in log input plots, supported our prediction that ground-dwelling arthropods would benefit from additions of dead wood. There were also no differences in saproxylic beetle abundance, richness, diversity, or composition among treatments. The findings from this study are encouraging in that arthropods seem less sensitive than expected to manipulations of dead wood in managed pine forests of the southeastern United States. Based on our results, we cannot recommend inputting large amounts of dead wood for conservation purposes, given the expense of such measures. However, the persistence of saproxylic beetles requires that an adequate amount of dead wood is available in the landscape, and we recommend that dead wood be retained whenever possible in managed pine forests.
Stochastic model predictive control with bounded control inputs: a vector space approach

We design receding horizon control strategies for stochastic discrete-time linear systems with additive (possibly) unbounded disturbances, while obeying hard bounds on the control inputs. We pose the problem of selecting an appropriate optimal controller on vector spaces of functions and show that the resulting optimization problem has a tractable convex solution. Under the assumption that the zero-input and zero-noise system is asymptotically stable, we show that the variance of the state is bounded when enforcing hard bounds on the control inputs, for any receding horizon implementation. Throughout the article we provide several examples that illustrate how quantities needed in the formulation of the resulting optimization problems can be calculated off-line, as well as comparative examples that illustrate the effectiveness of our control strategies.
Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro

Background The aim of this study was to investigate the anticancer effect and related mechanisms of gambogic acid (GA), a traditional Chinese medicine, on human leukemia cell line K562, together with the effect on bone marrow mononuclear cells (MNCs). Material/Methods K562 cells and MNCs were treated with various concentrations and treatment times of GA. Inhibitory rate was detected by use of the Cell Counting Kit-8 (CCK-8) assay. Apoptosis was analyzed by morphological detection, Annexin-V/PI doubling staining, and TUNEL assays. The expression changes of pivotal proteins were evaluated by Western blotting. Results GA not only suppressed cell proliferation, but also induced apoptosis of K562 cells in a dose-dependent manner. While it did not significantly inhibit cell proliferation of MNCs, it did induce apoptosis in a dose-dependent manner. CCK-8 assay revealed that the proliferation of K562 cells was significantly inhibited when the concentration of GA was more than 0.5 μM. Morphological detection showed the nuclei became denser and more intense orange in K562 cells after GA treatment compared with the untreated group. The expression levels of BCL-2, nuclear factor-κB (NF-κB), c-myc, phosphatidylinositol3-kinase (PI3K), and phosphorylation of serine-threonine kinase (p-AKT) were down-regulated by GA. Conclusions GA significantly suppressed the proliferation of K562 cells, but has less effect on MNCs. The inhibition of K562 cells proliferation and apoptosis induced by GA might be related to the down-regulation of BCL-2, NF-κB, c-myc, PI3K, and p-AKT.
Prevalence of colistin resistance gene (mcr-1) containing Enterobacteriaceae in feces of patients attending a tertiary care hospital and detection of a mcr-1 containing, colistin susceptible E. coli

The emergence of the plasmid-mediated mcr colistin resistance gene in the community poses a potential threat for treatment of patients, especially when hospitalized. The aim of this study was to determine the prevalence of all currently known mcr mediated colistin resistance gene in fecal samples of patients attending a tertiary care hospital. From November 2014 until July 2015, fecal samples of patients attending the Leiden University Medical Center were collected and screened for presence of mcr using real-time PCR. Two of 576 patients were positive for mcr-1, resulting in a prevalence of 0.35%, whereas no mcr-2 was found. One of these samples was culture negative, the second sample contained a blaCMY-2 and mcr-1 containing E.coli. This strain belonged to Sequence Type 359 and serotype O177:H21. The mcr-1 containing E.coli was phenotypically susceptible to colistin with a MIC of ≤ 0.25mg/l, due to a 1329bp transposon IS10R inserted into the mcr-1 gene as identified by WGS. This prevalence study shows that mcr-1 is present in low levels patients out of the community attending a hospital. Furthermore the study underlines the importance of phenotypical confirmation of molecular detection of a mcr-1 gene.
Gamma irradiation of 2'-deoxyadenosine in oxygen-free aqueous solutions: identification and conformational features of formamidopyrimidine nucleoside derivatives.

The two major radiation-induced decomposition products of 2'-deoxyadenosine in oxygen-free aqueous solution have been isolated by reverse-phase HPLC. The 1H and 13C NMR features of the two modified nucleosides obtained in DMSO-d6 are indicative of a similar formamidopyrimidine structure for the base residue (the ring-opened form of a C-8 hydroxylated purine). Interestingly, the sugar moiety exhibits a pyranose configuration, the two nucleosides being a pair of alpha and beta anomers. One-bond and long-range 1H-13C 2D NMR experiments have allowed the complete assignment of the carbon atoms. Confirmation of the base structure was obtained by 1H-15N scalar-correlated 2D NMR experiments. Attempts were made to characterize the expected furanose form of the initially generated formamidopyrimidine derivative. In this respect, isomerization reaction of the sugar moiety of the latter compound takes place rapidly after gamma-irradiation as inferred from 1H NMR analysis. The conformational study of the sugar moiety of the two pyranose anomers was inferred from detailed 600.13 MHz 1H NMR analysis in D2O. The alpha anomer exhibits a predominant 1C4 conformation whereas the beta anomer adopts preferentially a 4C1 conformation. In addition, the dynamic study of the restricted rotation of the formamido bond has revealed a 1/5 ratio in favor of the s-cis rotamer for both nucleosides. The energy barrier at coalescence was determined to be delta G# = 75.5 kJ.mol-1 (Tc = 370 K).
Haar measure for compact right topological groups

Compact right topological groups arise in topological dynamics and in other settings. Following H. Furstenberg's seminal work on distal flows, R. Ellis and I. Namioka have shown that the compact right topological groups of dynamical type always admit a probability measure invariant under the continuous left translations; however, this invariance property is insufficient to identify a unique probability measure (in contrast to the case of compact topological groups). In the present paper, we amplify on the proofs of Ellis and Namioka to show that a right invariant probability measure on the compact right topological group G exists provided G admits an appropriate system of normal subgroups, that it is uniquely determined and that it is also invariant under the continuous left translations. Using Namioka's work, we show that G has such a system of subgroups if its topological centre contains a countable dense subset, or if it is a closed subgroup of such a group.
Attachment Disorders: Review and Current Status

Abstract Developmental research on attachment has flourished in the past 15 years (C. H. Zeanah, 1996). However, there has been relatively scant empirical investigation of disorders in attachment. In this article, the pertinent developmental research on the attachment cycle is delineated and the current status of disordered attachment is examined. A particular focus is given to the conceptualization of the most severe form of disordered attachment, Reactive Attachment Disorder.
Limited Rationality and Strategic Interaction - the Impact of the Strategic Environment on Nominal Inertia

The evidence from many experiments suggests that people are heterogeneous with regard to their abilities to make rational, forward looking, decisions. This raises the question when the rational types are decisive for aggregate outcomes and when the boundedly rational types shape aggregate results. We examine this question in the context of a long-standing and important economic problem – the adjustment of nominal prices after an anticipated money shock. Our experiments show that when agents’ actions are strategic substitutes adjustment to the new equilibrium is extremely quick whereas under strategic complementarity adjustment lasts very long and is associated with relatively large real effects. This adjustment difference occurs because price expectations are very flexible under substitutability and very sticky under complementarity. Our results suggest that strategic complementarity does not only provide incentives for the rational types to partly mimic the behavior of the boundedly rational types but it also renders people less rational and forward looking. In addition, under complementarity people attribute less rationality to the other players.