Miracle-dz/UniFAR-FTUs huggingface dataset:
EyeBit: Eye-Tracking Approach for Enforcing Phishing Prevention Habits

This paper proposes a cognitive method with the goal to get end users into the habit of checking the address bar of the web browser. Earlier surveys of end user behavior emphasized that users become victims to phishing due to the lack of knowledge about the structure of URLs, domain names, and security information. Therefore, there exist many approaches to improve the knowledge of end users. However, the knowledge gained will not be applied unless end users are aware of the importance and develop a habit to check the browser's address bar for the URL structure and relevant security information. We assume that the habit of checking the bar will improve educational effect, user awareness of secure information, and detection accuracy even in the case of sophisticated phishing attacks. To assess this assumption, this paper conducts a participant-based experiment where 23 participants' eye movement records are analyzed, and observes that novices do not tend to have the said habit. We then consider a way for them to acquire these habits, and develop a system which requires them to look at the address bar before entering some information into web input forms. Our prototype named EyeBit is developed as a browser extension, which interacts with an eye-tracking device to check if the user looks at the browser's address bar. The system deactivates all input forms of the websites, and reactivates them only if the user has looked at the bar. This paper shows the preliminary results of our participant-based experiments, and discusses the effectiveness of our proposal, while considering the potential inconvenience caused by EyeBit.
NRG-X-Change - A Novel Mechanism for Trading of Renewable Energy in Smart Grids

In this position paper we propose a novel trading paradigm for buying and selling locally produced energy in the smart grid. Unlike recently proposed techniques that rely on predictions and a day-ahead market, here prosumers are billed by the distribute system operator according to their actual usage and rewarded based on their actual energy input, similar to the current state of affairs. Our mechanism achieves demand response by providing incentives to prosumers to balance their production and consumption out of their own self-interest. All rewards and payments are carried out using NRGcoin — a new decentralized digital currency similar to Bitcoin, that we introduce in this paper. Prosumers exchange NRGcoins with fiat currency on an exchange market for profit, or for paying their energy bills. We study the advantages of our proposed currency over traditional monetary payment and explore its benefits for all parties in the smart grid.
A large-scale study of the ultrawideband microwave dielectric properties of normal, benign and malignant breast tissues obtained from cancer surgeries

The development of microwave breast cancer detection and treatment techniques has been driven by reports of substantial contrast in the dielectric properties of malignant and normal breast tissues. However, definitive knowledge of the dielectric properties of normal and diseased breast tissues at microwave frequencies has been limited by gaps and discrepancies across previously published studies. To address these issues, we conducted a large-scale study to experimentally determine the ultrawideband microwave dielectric properties of a variety of normal, malignant and benign breast tissues, measured from 0.5 to 20 GHz using a precision open-ended coaxial probe. Previously, we reported the dielectric properties of normal breast tissue samples obtained from reduction surgeries. Here, we report the dielectric properties of normal (adipose, glandular and fibroconnective), malignant (invasive and non-invasive ductal and lobular carcinomas) and benign (fibroadenomas and cysts) breast tissue samples obtained from cancer surgeries. We fit a one-pole Cole–Cole model to the complex permittivity data set of each characterized sample. Our analyses show that the contrast in the microwave-frequency dielectric properties between malignant and normal adipose-dominated tissues in the breast is considerable, as large as 10:1, while the contrast in the microwave-frequency dielectric properties between malignant and normal glandular/fibroconnective tissues in the breast is no more than about 10%. For more information on this article, see medicalphysicsweb.org
Crime in Europe and the United States: Dissecting the ‘Reversal of Misfortunes’

Contrary to common perceptions, today both property and violent crimes (with the exception of homicides) are more widespread in Europe than in the United States, while the opposite was true thirty years ago. We label this fact as the ‘reversal of misfortunes’. We investigate what accounts for the reversal by studying the causal impact of demographic changes, incarceration, abortion, unemployment and immigration on crime. For this we use time series data (1970-2008) from seven European countries and the United States. We find that the demographic structure of the population and the incarceration rate are important determinants of crime. Our results suggest that a tougher incarceration policy may be an effective way to contrast crime in Europe. Our analysis does not provide information on how incarceration policy should be made tougher nor does it provide an answer to the question whether such a policy would also be efficient from a cost‐benefit point of view. We leave this to future research.
TernGrad: Ternary Gradients to Reduce Communication in Distributed Deep Learning

High network communication cost for synchronizing gradients and parameters is the well-known bottleneck of distributed training. In this work, we propose TernGrad that uses ternary gradients to accelerate distributed deep learning in data parallelism. Our approach requires only three numerical levels {-1,0,1}, which can aggressively reduce the communication time. We mathematically prove the convergence of TernGrad under the assumption of a bound on gradients. Guided by the bound, we propose layer-wise ternarizing and gradient clipping to improve its convergence. Our experiments show that applying TernGrad on AlexNet does not incur any accuracy loss and can even improve accuracy. The accuracy loss of GoogLeNet induced by TernGrad is less than 2% on average. Finally, a performance model is proposed to study the scalability of TernGrad. Experiments show significant speed gains for various deep neural networks. Our source code is available.
The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia

CRISPR/Cas9 technology was used to abrogate p210 oncoprotein expression in the Boff-p210 cell line, a pro-B line derived from interlukin-3-dependent Baf/3, that shows IL-3-independence arising from the constitutive expression of BCR-ABL p210. Using this approach, pools of Boff-p210-edited cells and single edited cell-derived clones were obtained and functionally studied in vitro. The loss of p210 expression in Boff-p210 cells resulted in the loss of ability to grow in the absence of IL-3, as the Baf/3 parental line, showing significantly increased apoptosis levels. Notably, in a single edited cell-derived clone carrying a frame-shift mutation that prevents p210 oncoprotein expression, the effects were even more drastic, resulting in cell death. These edited cells were injected subcutaneously in immunosuppressed mice and tumor growth was followed for three weeks. BCR/ABL-edited cells developed smaller tumors than those originating from unedited Boff-p210 parental cells. Interestingly, the single edited cell-derived clone was unable to develop tumors, similar to what is observed with the parental Baf/3 cell line. CRISPR/Cas9 genomic editing technology allows the ablation of the BCR/ABL fusion gene, causing an absence of oncoprotein expression, and blocking its tumorigenic effects in vitro and in the in vivo xenograft model of CML. The future application of this approach in in vivo models of CML will allow us to more accurately assess the value of CRISPR/Cas9 technology as a new therapeutic tool that overcomes resistance to the usual treatments for CML patients.
- 12913 IMPROVING OVERLAPPING BETWEEN TESTING AND

Testing components, prototypes and products comprise essential, but time consuming activities throughout the product development process particularly for complex iteratively designed products. To reduce product development time, testing and design processes are often overlapped. A key research question is how this overlapping can be planned and managed to minimise risks and costs. The first part of this research study investigates how a case study company plans testing and design processes and how they manage these overlaps. The second part of the study proposes a significant modification to the existing process configuration for design and testing, which explicitly identifies virtual testing, that is an extension to Computer Aided Engineering which mirrors the testing process through product modelling and simulation, as a distinct and significant activity used to (a) enhance and (b) replace some physical tests. The analysis shows how virtual testing can mediate information flows between overlapping (re)design and physical tests. The effects of virtual testing to support overlap of test and (re)design is analysed for the development phases of diesel engine design at a case study company. We assess the costs and risks of overlaps and their amelioration through targeted virtual testing. Finally, using the analysis of the complex interactions between (re)design, physical and virtual testing, and the scope for replacing physical with virtual testing is examined.
Long-term remineralizing effect of MI Paste Plus on regression of early caries after orthodontic fixed appliance treatment: a 12-month follow-up randomized controlled trial

Summary Background Casein-phosphopeptide-amorphous-calcium-fluoride-phosphate (CPP-ACFP) can remineralize subsurface lesions. It is the active ingredient of MI-Paste-Plus® (MPP). The long-term remineralization efficacy is unknown. Objective To evaluate the long-term effect of MPP versus a placebo paste on remineralization of enamel after fixed orthodontic treatment over a 12-month period. Design This trial was designed as a prospective, double-blinded, placebo-controlled RCT. Methods Patients with subsurface lesions scheduled for removal of the appliance were included. They applied either MPP or control paste once a day at bedtime for 12 months, complementary to normal oral hygiene. Main outcome measures Changes in enamel lesions (primary outcome) were fluorescence loss and lesion area determined by quantitative light-induced fluorescence (QLF). Secondary outcomes were Microbial composition, by conventional plating, and acidogenicity of plaque, by capillary ion analysis (CIA), and lesion changes scored visually on clinical photographs. Randomization Participants [age = 15.5 years (SD = 1.6)] were randomly assigned to either the MPP or the control group, as determined by a computer-randomization scheme, created and locked before the start of the study. Participants received neutral-coloured concealed toothpaste tubes marked A or B. Blinding The patients and the observers were blinded with respect to the content of tube A or B. Results A total of 51 patients were analysed; MPP (n = 25) versus control group (n = 26); data loss (n = 14). There was no significant difference between the groups over time for all the used outcome measures. There was a significant improvement in enamel lesions (fluorescence loss) over time in both groups (P < 0.001 and P < 0.001), with no differences between groups. Limitations Being an in vivo study, non-compliance of the subjects could have influenced the result. Conclusion The additional use of MPP in patients with subsurface enamel lesions after orthodontic fixed appliance treatment did not improve these lesions during the 1 year following debonding. Registration This trial is registered at the medical ethical committee of the VU Medical Centre in Amsterdam (NL.199226.029.07).
Severity strata for five patient‐reported outcomes in adults with atopic dermatitis

Several patient‐reported outcomes have been used to assess the burden of atopic dermatitis (AD). Some are disease specific, such as the Patient‐Oriented Eczema Measure (POEM), while others pertain to itch, for example the numerical rating scale (NRS)‐itch, ItchyQoL and 5‐D itch, or dermatological disease in general, for example the Dermatology Life Quality Index (DLQI). Development of severity strata is essential for proper interpretability of these assessments.
Novel Use of a Smartphone to Measure Standing Balance

Background Balance assessment and training is utilized by clinicians and their patients to measure and improve balance. There is, however, little consistency in terms of how clinicians, researchers, and patients measure standing balance. Utilizing the inherent sensors in every smartphone, a mobile application was developed to provide a method of objectively measuring standing balance. Objective We aimed to determine if a mobile phone application, which utilizes the phone’s accelerometer, can quantify standing balance. Methods Three smartphones were positioned simultaneously above the participants’ malleolus and patella and at the level of the umbilicus. Once secured, the myAnkle application was initiated to measure acceleration. Forty-eight participants completed 8 different balance exercises separately for the right and left legs. Accelerometer readings were obtained from each mobile phone and mean acceleration was calculated for each exercise at each ankle and knee and the torso. Results Mean acceleration vector magnitude was reciprocally transformed to address skewness in the data distribution. Repeated measures ANOVAs were completed using the transformed data. A significant 2-way interaction was revealed between exercise condition and the body position of the phone (P<.001). Post-hoc tests indicated higher acceleration vector magnitude for exercises of greater difficulty. ANOVAs at each body position were conducted to examine the effect of exercise. The results revealed the knee as the location most sensitive for the detection of differences in acceleration between exercises. The accelerometer ranking of exercise difficulty showed high agreement with expert clinical rater rankings (kappa statistic>0.9). Conclusions The myAnkle application revealed significantly greater acceleration magnitude for exercises of greater difficulty. Positioning of the mobile phone at the knee proved to be the most sensitive to changes in accelerometer values due to exercise difficulty. Application validity was shown through comparison with clinical raters. As such, the myAnkle app has utility as a measurement tool for standing balance.
Technical Report about Tiramisu: a Three-Layered Abstraction for Hiding Hardware Complexity from DSL Compilers

High-performance DSL developers work hard to take advantage of modern hardware. The DSL compilers have to build their own complex middle-ends before they can target a common back-end such as LLVM, which only handles single instruction streams with SIMD instructions. We introduce Tiramisu, a common middle-end that can generate efficient code for modern processors and accelerators such as multicores, GPUs, FPGAs and distributed clusters. Tiramisu introduces a novel three-level IR that separates the algorithm, how that algorithm is executed, and where intermediate data are stored. This separation simplifies optimization and makes targeting multiple hardware architectures from the same algorithm easier. As a result, DSL compilers can be made considerably less complex with no loss of performance while immediately targeting multiple hardware or hardware combinations such as distributed nodes with both CPUs and GPUs. We evaluated Tiramisu by creating a new middle-end for the Halide and Julia compilers. We show that Tiramisu extends Halide and Julia with many new capabilities including the ability to: express new algorithms (such as recurrent filters and non-rectangular iteration spaces), perform new complex loop nest transformations (such as wavefront parallelization, loop shifting and loop fusion) and generate efficient code for more architectures (such as combinations of distributed clusters, multicores, GPUs and FPGAs). Finally, we demonstrate that Tiramisu can generate very efficient code that matches the highly optimized Intel MKL gemm (generalized matrix multiplication) implementation, we also show speedups reaching 4X in Halide and 16X in Julia due to optimizations enabled by Tiramisu.
How Machines are Serviced - Design of a Virtual Reality-based Training System for Technical Customer Services

Training service provider is a crucial factor for high-quality service delivery. Due to the rise of new devices, reviving Virtual Reality (VR) offer great opportunities to overcome current training challenges. As various new interaction and visualization systems push into market, guidance on how to design VR-based training systems is necessary. The presented use case is based on technicians in technical customer services (TCS) who tackle increasing complexity of machines. We fill the research gap of design knowledge by (1) analyzing the domain in a multi-method approach to elicit meta-requirements, (2) proposing design principles, and (3) instantiating them in a prototype. The interaction of the user with the training system was identified as key aspect to foster learning. We follow a design science research approach (DSR) combing the build-phase with agile evaluation cycles obtaining focus groups and demonstration with a prototype.
C‐C motif ligand 5 promotes migration of prostate cancer cells in the prostate cancer bone metastasis microenvironment

Chemokines and their receptors have key roles in cancer progression. The present study investigated chemokine activity in the prostate cancer bone metastasis microenvironment. Growth and migration of human prostate cancer cells were assayed in cocultures with bone stromal cells. The migration of LNCaP cells significantly increased when co‐cultured with bone stromal cells isolated from prostate cancer bone metastases. Cytokine array analysis of conditioned medium from bone stromal cell cultures identified CCL5 as a concentration‐dependent promoter of LNCaP cell migration. The migration of LNCaP cells was suppressed when C‐C motif ligand 5 (CCL5) neutralizing antibody was added to cocultures with bone stromal cells. Knockdown of androgen receptor with small interfering RNA increased the migration of LNCaP cells compared with control cells, and CCL5 did not promote the migration of androgen receptor knockdown LNCaP. Elevated CCL5 secretion in bone stromal cells from metastatic lesions induced prostate cancer cell migration by a mechanism consistent with CCL5 activity upstream of androgen receptor signaling.
A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel

Ion channels are important therapeutic targets, and their pharmacology is becoming increasingly important. However, knowledge of the mechanism of interaction of the activators and ion channels is still limited due to the complexity of the mechanisms. A statistical thermodynamic model has been developed in this study to characterize the cooperative binding of activators to ion channels. By fitting experimental concentration-response data, the model gives eight parameters for revealing the mechanism of an activator potentiating an ion channel, i.e., the binding affinity (KA), the binding cooperative coefficients for two to four activator molecules interacting with one channel (γ, μ, and ν), and the channel conductance coefficients for four activator binding configurations of the channel (a, b, c, and d). Values for the model parameters and the mechanism underlying the interaction of ztz240, a proven KCNQ2 activator, with the wild-type channel have been obtained and revealed by fitting the concentration-response data of this activator potentiating the outward current amplitudes of KCNQ2. With these parameters, our model predicted an unexpected bi-sigmoid concentration-response curve of ztz240 activation of the WT-F137A mutant heteromeric channel that was in good agreement with the experimental data determined in parallel in this study, lending credence to the assumptions on which the model is based and to the model itself. Our model can provide a better fit to the measured data than the Hill equation and estimates the binding affinity, as well as the cooperative coefficients for the binding of activators and conductance coefficients for binding states, which validates its use in studying ligand-channel interaction mechanisms.
Introduction of a male-harming mitochondrial haplotype via ‘Trojan Females’ achieves population suppression in fruit flies

Pests are a global threat to biodiversity, ecosystem function, and human health. Pest control approaches are thus numerous, but their implementation costly, damaging to non-target species, and ineffective at low population densities. The Trojan Female Technique (TFT) is a prospective self-perpetuating control technique that is species-specific and predicted to be effective at low densities. The goal of the TFT is to harness naturally occurring mutations in the mitochondrial genome that impair male fertility while having no effect on females. Here, we provide proof-of-concept for the TFT, by showing that introduction of a male fertility-impairing mtDNA haplotype into replicated populations of Drosophila melanogaster causes numerical population suppression, with the magnitude of effect positively correlated with its frequency at trial inception. Further development of the TFT could lead to establishing a control strategy that overcomes limitations of conventional approaches, with broad applicability to invertebrate and vertebrate species, to control environmental and economic pests. DOI: http://dx.doi. org/10.7554/eLife.23551. 001
Relationship between maceration and wound healing on diabetic foot ulcers in Indonesia: a prospective study

The aim of this study was to clarify the relationship between maceration and wound healing. A prospective longitudinal design was used in this study. The wound condition determined the type of dressings used and the dressing change frequency. A total of 62 participants with diabetic foot ulcers (70 wounds) were divided into two groups: non‐macerated (n = 52) and macerated wounds (n = 18). Each group was evaluated weekly using the Bates–Jensen Wound Assessment Tool, with follow‐ups until week 4. The Mann–Whitney U test showed that the changes in the wound area in week 1 were faster in the non‐macerated group than the macerated group (P = 0·02). The Pearson correlation analysis showed a moderate correlation between maceration and wound healing from enrolment until week 4 (P = 0·002). After week 4, the Kaplan–Meier analysis showed that the non‐macerated wounds healed significantly faster than the macerated wounds (log‐rank test = 19·378, P = 0·000). The Cox regression analysis confirmed that maceration was a significant and independent predictor of wound healing in this study (adjusted hazard ratio, 0·324; 95% CI, 0·131–0·799; P = 0·014). The results of this study demonstrated that there is a relationship between maceration and wound healing. Changes in the wound area can help predict the healing of wounds with maceration in clinical settings.