Miracle-dz/UniFAR-FTUs huggingface dataset:
Antioxidant and antimicrobial potentials of Serbian red wines produced from international Vitis vinifera grape varieties.

BACKGROUND Antioxidant and antimicrobial potentials of Serbian red wines produced from different international Vitis vinifera grape varieties and their correlation with contents of phenolic compounds were studied by spectrophotometric and chromatographic methods. The antioxidant activity of red wines was estimated through their ability to scavenge 2,2'-diphenyl-1-picrylhydrazyl free radical (DPPH(•) ). The red wines, gallic acid, (+)-catechin and quercetin were screened in vitro for antimicrobial activity against Gram-positive and Gram-negative strains using microdilution and disc diffusion techniques. RESULTS Excellent correlations between the contents of quercetin-3-glucoside (R(2) = 0.9463) and quercetin (R(2) = 0.9337) and DPPH(•) -scavenging ability of the red wines were found. Serbian red wines exhibited significant activity against Staphylococcus aureus, Listeria inocua, Micrococcus flavus, Sarcina lutea, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Shigella sonnei strains, which was in correlation with their phenolic composition and antioxidant activity. The compounds gallic acid, quercetin and (+)-catechin showed high activity against B. subtilis, S. aureus, S. lutea and M. flavus Gram-positive and S. enteritidis and P. aeruginosa Gram-negative strains. CONCLUSION The results show that quercetin-3-glucoside and quercetin concentrations can be used as markers for the determination of antioxidant and antimicrobial potentials of red wines.
Bat-associated Rabies Virus in Skunks

Rabies was undetected in terrestrial wildlife of northern Arizona until 2001, when rabies was diagnosed in 19 rabid skunks in Flagstaff. Laboratory analyses showed causative rabies viruses associated with bats, which indicated cross-species transmission of unprecedented magnitude. Public health infrastructure must be maintained to address emerging zoonotic diseases.
Psychosocial correlates of human immunodeficiency virus infected patients

Background: Reactions of people to a diagnosis of HIV and its effect on well-being vary greatly. There is paucity of Indian studies in this area. Aim: To assess the level of anxiety, depression and quality of life in HIV seropositive individuals. Materials and Methods: It was a descriptive cross-sectional study with a sample size of 50 seropositive individuals. They were assessed using a specially prepared proforma containing several questions pertaining to their demographic profile, details of HIV status and high-risk behavior, questions on family support and discrimination. In addition, all subjects were evaluated with WHO well-being index, General Health Questionnaire (GHQ), and Hospital Anxiety, and Depression Scale. Results: Anxiety was noted in 54% of the individuals whereas only 30% suffered from depression. GHQ showed psychological morbidity in 44% individuals. WHO well-being index noted poor psychological well-being in 46% of individuals. Conclusion: The high level of anxiety and depression in HIV seropositive subjects reiterates the importance of psychological counseling in HIV afflicted individuals in conjunction with suitable pharmacotherapy.
Strategic bidding in electricity markets with only renewables

Presently, renewable power plants participating in electricity markets receive payments at a market price determined by the marginal cost of the marginal generator, generally a conventional power plant. In a market with only renewables, market clearing prices would be determined by the marginal cost of renewable power plants, which is generally close to zero, resulting in capital cost recovery problems for renewable power producers. Hence, in a market with only renewables, a new price-setting mechanism is needed which does not depend on marginal costs. In this paper, we analyze a model of such a mechanism for when all energy production is from renewable power plants such as wind and solar. We consider a mechanism in which producers bid single prices instead of supply functions. While such a price has no physical basis, it enables producers to recover sunk costs and parallels pricing in less regulated, low-marginal cost industries like software and digital media. We do not advocate the adoption of this mechanism, but rather find it useful for understanding renewable-only markets because it is amenable to analysis of strategic behavior under uncertainty. Specifically, we analyze a game between two renewable producers with random capacities described by arbitrary probability distributions. The producers compete to fulfill a random demand. We find that symmetry (in terms of size/parameters) among producers and variance in producer capacities tend to increase competition. We demonstrate our results via several case studies.
Reversal distance for partially ordered genomes

MOTIVATION The total order of the genes or markers on a chromosome inherent in its representation as a signed per-mutation must often be weakened to a partial order in the case of real data. This is due to lack of resolution (where several genes are mapped to the same chromosomal position) to missing data from some of the datasets used to compile a gene order, and to conflicts between these datasets. The available genome rearrangement algorithms, however, require total orders as input. A more general approach is needed to handle rearrangements of gene partial orders. RESULTS We formalize the uncertainty in gene order data by representing a chromosome from each genome as a partial order, summarized by a directed acyclic graph (DAG). The rearrangement problem is then to infer a minimal sequence of reversals for transforming any topological sort of one DAG to any one of the other DAG. Each topological sort represents a possible linearization compatible with all the datasets on the chromosome. The set of all possible topological sorts is embedded in each DAG by appropriately augmenting the edge set, so that it becomes a general directed graph (DG). The DGs representing chromosomes of two genomes are combined to produce a bicoloured graph from which we extract a maximal decomposition into alternating coloured cycles, and from which, in turn, an optimal sequence of reversals can usually be identified. We test this approach on simulated incomplete comparative maps and on cereal chromosomal maps drawn from the Gramene browser.
Distributed Patterns of Reactivation Predict Vividness of Recollection

According to the principle of reactivation, memory retrieval evokes patterns of brain activity that resemble those instantiated when an event was first experienced. Intuitively, one would expect neural reactivation to contribute to recollection (i.e., the vivid impression of reliving past events), but evidence of a direct relationship between the subjective quality of recollection and multiregional reactivation of item-specific neural patterns is lacking. The current study assessed this relationship using fMRI to measure brain activity as participants viewed and mentally replayed a set of short videos. We used multivoxel pattern analysis to train a classifier to identify individual videos based on brain activity evoked during perception and tested how accurately the classifier could distinguish among videos during mental replay. Classification accuracy correlated positively with memory vividness, indicating that the specificity of multivariate brain patterns observed during memory retrieval was related to the subjective quality of a memory. In addition, we identified a set of brain regions whose univariate activity during retrieval predicted both memory vividness and the strength of the classifier's prediction irrespective of the particular video that was retrieved. Our results establish distributed patterns of neural reactivation as a valid and objective marker of the quality of recollection.
Experimental investigation on pore size distribution and drying kinetics during lyophilization of sugar solutions

The pore structure is a decisive factor for the process efficiency and product quality of freeze dried products. In this work the two-dimensional ice crystal structure was investigated for maltodextrin solutions with different concentrations by a freeze drying microscope. The resulting drying kinetics was investigated for different pore structures. Additionally the three-dimensional pore structure of the freeze dried samples was measured by µ-computed tomography and the pore size distribution was quantified by image analysis techniques. The two- and three-dimensional pore size distributions were compared and linked to the drying kinetics.Keywords: pore size distribution; freeze drying; maltodextrin solution; freeze drying microscope
Degrees of Humanness in Technology: What Type of Trust Matters?

REQUIRED) Significant research has shown the impact of trust (i.e., trusting beliefs) in information technology (IT) settings. Most research has investigated trust between the consumer and the e-vendor. However, IT researchers have begun to investigate user trust in the technology artifact itself (trust-in-technology). This research has measured trust using both interpersonal trust variables (ability, benevolence, and integrity) and system-like trust variables (functionality, helpfulness, and reliability). Both measures seem to work. However, it is unclear when researchers should use interpersonal versus system-like trust-intechnology constructs. This study hypothesizes interpersonal trust will have a stronger influence on users’ outcomes when the technology is more human-like. By contrast, system-like trust will have a stronger influence when the technology is less human-like. We validate this concept by measuring how both interpersonal and system-like trust predict user outcomes across three technologies: Facebook (high humanness), a recommendation agent (medium humanness), and Microsoft Access (low humanness).
The Discrimination, Acquisition, and Retention of Aiming Movements Made with and without Elastic Resistance

Two experiments were conducted to compare the discrimination, acquisition, and retention of movements made with and without elastic resistance. Using methods from psychophysics, Experiment 1 revealed that a discrete 800-mm movement could be discriminated equally precisely when it was performed with and without elastic resistance. Similarly, there was no difference in the spatial accuracy of a discrete aiming movement made with and without elastic resistance when extended practice with knowledge of results (KR) was provided in Experiment 2. Contrary to expectation, when KR about the outcome of the movement was removed on a retention test given 24 h after practice, the accuracy of the movements made with elastic resistance declined much more rapidly than those made without resistance. These findings question the common assumption that elastic resistance is a desirable characteristic of a control mechanism. Actual or potential applications of this research include the design of control mechanisms that facilitate performance under a variety of task and environmental conditions.
Elucidating User Behavior in Music Services Through Persona and Gender

Prior user studies in the music information retrieval field have identified different personas representing the needs, goals, and characteristics of specific user groups for a user-centered design of music services. However, these per-sonas were derived from a qualitative study involving a small number of participants and their generalizability has not been tested. The objectives of this study are to explore the applicability of seven user personas, developed in prior research, with a larger group of users and to identify the correlation between personas and the use of different types of music services. In total, 962 individuals were surveyed in order to understand their behaviors and preferences when interacting with music streaming services. Using a stratified sampling framework, key characteristics of each persona were extracted to classify users into specific per-sona groups. Responses were also analyzed in relation to gender, which yielded significant differences. Our findings support the development of more targeted approaches in music services rather than a universal service model.
Characterization of Blood Oxidative Stress in Type 2 Diabetes Mellitus Patients: Increase in Lipid Peroxidation and SOD Activity

This study evaluated the oxidative stress through enzymatic and nonenzymatic biomarkers in diabetic patients with and without hypertension and prediabetics. The SOD and CAT (in erythrocytes) and GPx (in plasma) enzymatic activities, plasma levels of lipid peroxidation, and total thiols were measured in the blood of 55 subjects with type 2 diabetes and 38 subjects without diabetes (9 pre-diabetics and 29 controls) aged 40–86 years. The total SOD activity and the lipid peroxidation were higher in diabetics compared to nondiabetics. In stratified groups, the total SOD activity was different for the hypertensive diabetics compared to the prediabetics and normotensive controls. Lipid peroxidation was significantly higher in both groups of diabetics (hypertensive and normotensive) compared to prediabetic groups and hypertensive and normotensive controls. There was no significant difference in the CAT and GPx activities, as well as in the concentration of total thiols in the groups studied. Present data strongly suggest the involvement of oxidative stress in the pathophysiology of diabetes, revealing that the increased lipid peroxidation has a close relationship with high glucose levels, as observed by the fasting glucose and HbA1c levels. The results evidence the correlation between lipid peroxidation and DM, irrespective of the presence of hypertension.
Application of radio-immunoassays to assess the fate of estrogen EDCs in full scale wastewater treatment plants

Wastewater effluents have been documented as major contributors of hormone endocrine disrupting compounds (EDCs) in to the aquatic ecosystem. The need for rapid, simple and cost effective methods to detect these EDCs has increased. The use of Radio-immunoassays (RIA) were assessed to determine the fate of estradiol in a laboratory batch test and the three natural estrogens (estrone (E1), estradiol (E2) and estriol (E3)) in wastewater treatment plants (WWTPs) with different types of configurations. Precision of the RIAs were done using intra-assay and inter-assay validations. The E2 intra-assay variation was <8% and inter-assay variation was <11% for standards 1 to 6. E1 RIA showed less than 8% for both the intra-assay and inter-assay variations. E3 RIA showed extremely good variations with both the intra and inter-assay variations being below <8% for all standards. The lab scale investigation showed a 94% reduction in E2 after 5 h and after 10 h both E2 and E1 were no longer detected. The simple activated sludge process, the biological nutrient removal (BNR) activated sludge process and the oxidation pond had final effluent concentrations of 10.75, 5.96 and 25.48 pg E2/mL respectively; 20.80, 9.30 and 46.55 pg E1/mL, respectively, and 0.12, 0.07 and 0.17 ng E3/mL, respectively. Thus far findings indicated that the RIA can be employed as a rapid technique for detection of natural estrogens in water. Results indicate that these potential problematic hormone EDCs are still present in final wastewater effluents that are discharged in to South African aquatic sources.
Low-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis

Background: Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited. Methods: The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported. Results: Both patients with metastatic melanoma, aged 48 and 51 years, had significant symptomatic and radiological improvement with low-dose bevacizumab treatment. Doses as low as 5 mg/kg every 6 weeks and 7.5 mg/kg i.v. every 4 weeks were used and were highly effective. Conclusions: Low-dose bevacizumab is a solid option in the management of edema associated with radiation necrosis.
Lifelong neurogenesis in the cerebral ganglion of the Chinese mud snail, Cipangopaludina chinensis

A small group of Gastropods possessing giant neurons have long been used to study a wide variety of fundamental neurophysiological phenomena. However, the majority of gastropods do not have large neurons but instead have large numbers of small neurons and remain largely unstudied. We explored neuron size and rate of increase in neuron numbers in the Chinese mud snail, Cipangopaludina chinensis.
Recent Advances in Experimental Studies of Social Dilemma Games

I provide a broad overview of the findings reported in the articles submitted for this special volume on experimental studies of social dilemma problems. I start by providing a synopsis of where current research stands on this topic. Then I go on to discuss the specific papers and how those papers extend our knowledge in this area and add value to the current state of the art.
Online Stochastic Optimization under Correlated Bandit Feedback

In this paper we consider the problem of online stochastic optimization of a locally smooth function under bandit feedback. We introduce the high-confidence tree (HCT) algorithm, a novel anytime χ-armed bandit algorithm, and derive regret bounds matching the performance of state-of-the-art algorithms in terms of the dependency on number of steps and the near-optimality dimension. The main advantage of HCT is that it handles the challenging case of correlated bandit feedback (reward), whereas existing methods require rewards to be conditionally independent. HCT also improves on the state-of-the-art in terms of the memory requirement, as well as requiring a weaker smoothness assumption on the mean-reward function in comparison with the existing anytime algorithms. Finally, we discuss how HCT can be applied to the problem of policy search in reinforcement learning and we report preliminary empirical results.
Photon Upconversion at Crystalline Organic–Organic Heterojunctions

Triplet transfer across a surface-anchored metal-organic-framework heterojunction is demonstrated by the observation of triplet-triplet annihilation photon -upconversion in a sensitizer-emitter heterostructure. Upconversion thresholds under 1 mW cm-2 are achieved. In the broader context, the double-electron-exchange mechanism of triplet transfer indicates that the heterojunction quality is sufficient for electrons to move between layers in this solution-processed crystalline heterostructure.
Do Adolescents With a Severe Idiopathic Scoliosis Have Higher Locations of the Conus Medullaris Than Healthy Adolescents?

Background: Based on the "uncoupled neuro-osseous growth" theory, the hypothesized etiology of adolescent idiopathic scoliosis (AIS), a shorter spinal cord or a higher conus location, could be found in AIS patients. However, there are no case-control studies with large samples regarding the conus position in AIS patients. This study is performed to determine the positions of the conus medullaris in AIS patients with a large curve magnitude when compared with healthy adolescents and to investigate the relationships of the conus locations with patients' age, sex, curve magnitude, and curve pattern. Methods: Two hundred forty AIS patients with a Cobb angle greater than 40 degree were included in this study, and 120 age-matched healthy adolescents were recruited to serve as controls. Both AIS patients and healthy controls displayed normal on neurological examinations. On sagittal magnetic resonance images of the spine in both groups, the position on the conus medullaris relative to lumbar vertebrae and intervertebral disk space was measured according to a standard method. Results: There was no significant difference in the distributions of the positions of the conus medullaris in AIS patients and healthy controls (P = 0.448). In both groups, the mean position of the conus medullaris was located at the same level, which was the lower 1/3 of L1 (range: the middle third of T12 to L2-3 disk space). The conus positions were neither significantly different among adolescents of different ages (P = 0.662 in AIS and P = 0.897 in controls) nor between boys and girls (P = 0.875 in AIS and P = 0.675 in controls). It was shown that the conus position was not significantly different among AIS patients with different curve severity (F = 0.314, P = 0.731) and curve patterns (F = 0.097, P = 0.756). Conclusions: The mean and the distribution of the conus locations were similar for AIS patients and the controls. No significant associations of the conus position with curve severity and with curve patterns were found, indicating that the conus location might not be involved in the pathogenesis and curve progression of AIS. Level of Evidence: Level III.
D2O and HDS in the coma of 67P/Churyumov–Gerasimenko

The European Rosetta mission has been following comet 67P/Churyumov–Gerasimenko for 2 years, studying the nucleus and coma in great detail. For most of these 2 years the Rosetta Orbiter Sensor for Ion and Neutral Analysis (ROSINA) has analysed the volatile part of the coma. With its high mass resolution and sensitivity it was able to not only detect deuterated water HDO, but also doubly deuterated water, D2O and deuterated hydrogen sulfide HDS. The ratios for [HDO]/[H2O], [D2O]/[HDO] and [HDS]/[H2S] derived from our measurements are (1.05 ± 0.14) × 10−3, (1.80 ± 0.9) × 10−2 and (1.2 ± 0.3) × 10−3, respectively. These results yield a very high ratio of 17 for [D2O]/[HDO] relative to [HDO]/[H2O]. Statistically one would expect just 1/4. Such a high value can be explained by cometary water coming unprocessed from the presolar cloud, where water is formed on grains, leading to high deuterium fractionation. The high [HDS]/[H2S] ratio is compatible with upper limits determined in low-mass star-forming regions and also points to a direct correlation of cometary H2S with presolar grain surface chemistry. This article is part of the themed issue ‘Cometary science after Rosetta’.
Recombinant Thrombomodulin Inhibits Thrombin-Induced Vascular Endothelial Growth Factor Production in Neuronal Cells

Thrombin is a serine protease which is generated from its precursor prothrombin by the activation of the blood coagulation cascade. Thrombin converts fibrinogen to fibrin, activates platelets and several coagulation factors, and plays a central role in thrombosis and hemostasis by regulating platelet aggregation and blood coagulation. Here, we show that thrombn enhanced vascular endothelial growth factor (VEGF) production in a dose- and time-dependent manner in the supernatant of cultured PC-12 cells, as determined by enzyme-linked immunosorbent assay (ELISA). Thrombin receptor agonist peptide (SFLLRNPNDKYEPF, TRAP) exerted an effect similar to thrombin on VEGF production. Thrombin-induced VEGF production was significantly attenuated by recombinant human thrombomodulin (rTM) and its minimal functional domain E456. Furthermore, the antioxidant N-acetyl-L-cysteine (NAC) markedly inhibited thrombin-induced VEGF production. Thus, rTM and NAC apparently inhibited the effect of thrombin on VEGF production in neuronal cells.
Contamination of Soil by Copper Affects the Dynamics, Diversity, and Activity of Soil Bacterial Communities Involved in Wheat Decomposition and Carbon Storage

ABSTRACT A soil microcosm experiment was conducted to evaluate the influence of copper contamination on the dynamics and diversity of bacterial communities actively involved in wheat residue decomposition. In the presence of copper, a higher level of CO2 release was observed, which did not arise from greater wheat decomposition but from a higher level of stimulation of soil organic matter mineralization (known as the priming effect). Such functional modifications may be related to significant modifications in the diversity of active bacterial populations characterized using the DNA stable-isotope probing approach.