Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of an Interactive Game-Based Rehabilitation Tool for Dynamic Balance Training

Abstract Conventional physical therapy techniques have been shown to improve balance, mobility, and gait following neurological injury. Treatment involves training patients to transfer weight onto the impaired limb to improve weight shift while standing and walking. Visual biofeedback and force plate systems are often used for treatment of balance and mobility disorders. Researchers have also been exploring the use of video game consoles such as the Nintendo Wii Fit as rehabilitation tools. Case studies have demonstrated that the use of video games may have promise for balance rehabilitation. However, initial usability studies and anecdotal evidence suggest that the current commercial games are not compatible with controlled, specific exercise required to meet therapy goals. Based on focus group data and observations with patients, a game has been developed to specifically target weight shift training using an open source game engine and the Nintendo Wii Fit Balance Board. The prototype underwent initial usability testing with a sample of clinicians and with persons with neurological injury. Overall, feedback was positive, and areas for improvement were identified. This preliminary research provides support for the development of a game that caters specifically to the key requirements of balance rehabilitation.
Active scatter factor (HGF/SF) in proliferative vitreoretinal disease.

PURPOSE Hepatocyte growth factor/scatter factor (HGF/SF) possesses mitogenic, motogenic, and morphogenic properties and has recently been implicated in various retinal diseases. The role of HGF/SF in proliferative vitreoretinal disease was investigated. METHODS Sections of epiretinal membranes were stained immunohistochemically for cytokeratins, to identify HRPE cells, and for HGF/SF receptor (c-Met). Cultured HRPE cells were stained for c-Met and investigated for shape change in response to HGF/SF, by using image analysis. The dose-response relationship for HRPE cells to HGF/SF was investigated by a cell migration assay and the specificity of this response evaluated by a neutralization experiment. Subretinal fluid (SRF) and vitreous from patients with retinal detachment and proliferative vitreoretinopathy (PVR) plus vitreous from eyes obtained after death, eyes with macular hole, and eyes with proliferative diabetic retinopathy (PDR) were investigated for the presence of HGF/SF using an enzyme-linked immunosorbent assay (ELISA). HGF/SF activity was measured using an MDCK cell scatter assay. RESULTS HRPE cells in epiretinal membranes and in culture expressed c-Met. Cultured HRPE cells responded to HGF/SF by an epithelial-to-mesenchymal shape change and by cell migration, a response that increased with increasing concentrations of HGF/SF. This response was reduced in the presence of neutralizing antibody. There was evidence of HGF/SF in increasing concentrations in more severe PVR and in PDR when measured by ELISA, and, conversely, there was evidence of correspondingly decreasing HGF/SF activity when measured by MDCK cell scatter assay in these diseases. CONCLUSIONS HGF/SF is present in normal and pathologic vitreous. HRPE cells respond by shape change and cell migration to HGF/SF. Concentrations of HGF/SF increase in proliferative vitreoretinal disease and increase in turn with increased severity of the disease, but HGF/SF bioactivity decreases (consistent with activator depletion). These findings are consistent with the hypothesis that HGF/SF may play a role in the HRPE mesenchymal transformation that typifies PVR.
Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation

The autosomal recessive scid mutation results in defective immunoglobulin and T cell receptor gene rearrangement. The scid mutation occurred in the allotype congenic C.B-17 line, and up to 25% of C.B-17 scid mice spontaneously produce both T cells and immunoglobulin, a phenotype known as "leaky. " Moreover, introduction of neonatal T cells into C.B-17 scid mice leads to immunoglobulin production by 100% of animals. We have produced mice homozygous for both the scid and beige mutations. By contrast with C.B-17 scid mice, BALB/c scid.beige mice have a < 2% incidence of "leakiness. " This percentage does not increase with age, and introduction of neonatal T cells fails to rescue immunoglobulin production. This suggests that a gene (or genes) closely linked to the beige locus regulates B and/or T cell development.
GROWTH AND NUTRITIONAL STATUS OF THE FIRST SIX MONTHS OF LIFE AMONG SELECTED HOSPITALS--NAIROBI PROVINCE.

BACKGROUND Exclusive breastfeeding for infants is recommended for the first six months for optimal health, development and growth. However, there is limited data on infant feeding practices and nutrition status of infants in Nairobi. OBJECTIVE To assess infant growth and nutritional status and compare with feeding practices in the first six months of life in selected hospitals, Nairobi Province. DESIGN Prospective cohort design SETTING Five major hospitals in Nairobi namely; The Aga Khan, Pumwani Maternity, Mater Misercordiae, St Mary's Langata and Jamaa Hospitals. SUBJECTS A sample of 692 mother-infant pairs were recruited at birth and followed up until six months. INTERVENTION There was no direct experimental intervention, but there was observation of infant feeding practices, weight and height measurement was recorded every four weeks and determination of nutrition status of the infants for a period of six months. MAIN OUTCOME MEASURES Nutritional status and infant feeding practices in the first six months. RESULTS Slightly more than half (58.8%) of the mothers were formally employed and the rest were self employed. The mean age of the mothers was 28.3 ± 4.9 years. The mean income was KES 26,360 ± 34,696. The mean birth weight of infants was 3.24 ± 0.43 kg and 53.3% of all infants were male. Above 80% of infants were within normal weight based on weight for age Z-scores (WAZ) at 6, 10, 14 and 23 weeks. The prevalence of overweight based on WAZ was 9.5%, 11.6%, 11.9% and 11% at 6, 14, 19 and 23 weeks, respectively. There were no significant (P > 0.05) differences in WAZ between infants on different feeding methods. CONCLUSIONS There was no significant difference in weight or length gain among children that were fully breastfed in comparison to those who were given infant formula or had mixed feeding. However, there was concern over the proportion of overweight infants, as the condition may lead to long term health problems.
Fine-grained adaptive CMP cache sharing through access history exploitation

Advances in semiconductor technologies have enabled the integration of multiple processor cores as well as varying sizes of L1 and L2 caches on a single chip. The ever growing complexity and diversity of the associated workloads impose a crucial challenge on the organization and management of the on-chip cache resources. As each core generates a varying amount of accesses to each cache line during execution, sharing a single L2 cache among all the cores can minimize off-chip misses. However, each access to a shared L2 cache imposes significant performance and power overhead, as the tags of all the blocks on a cache line need to be compared in parallel. To efficiently utilize cache resources while saving power, we present in this paper a fine-grained L2 cache management technique with minimum hardware overhead. Each core is allowed to set an ownership bit in an L2 cache block to directly signify the necessity of tag checking, thus reducing the latency and power consumption of each cache access. Joint block ownership approaches provide shareability, thus precluding costly data replication from which private L2 caches typically suffer. Meanwhile, through monitoring line-based access histories, a core that produces a large amount of misses is precluded from replacing blocks belonging to other cores, thus efficiently attaining fine-grained cache partitioning. Experimental results confirm that the proposed technique can effectively reduce the access latency and power consumption of traditional shared L2 caches, accompanied by additionally a slight reduction in the miss rate.
Coopetitive Business Models in Future Mobile Broadband with Licensed Shared Access (LSA)

Spectrum scarcity forces mobile network operators (MNOs) providing mobile broadband services to develop new business models that address spectrum sharing. It engages MNOs into coopetitive relationship with incumbents. Licensed Shared Access (LSA) concept complements traditional licensing and helps MNOs to access new spectrum bands on a shared basis. This paper discusses spectrum sharing with LSA from business perspective. It describes how coopetition and business model are linked conceptually, and identifies the influence of coopetition on future business models in LSA. We develop business models for dominant and challenger MNOs in traditional licensing and future with LSA. The results indicate that coopetition and business model concepts are linked via value co-creation and value co-capture. LSA offers different business opportunities to dominant and challenger MNOs. Offering, value proposition, customer segments and differentiation in business models become critical in mobile broadband.
Founding conditions and the survival of new firms

We analyze the effects of founding conditions on the survival of new firms. We allow the effects of founding conditions to be transitory and estimate how long such effects last. Our findings indicate that founding effects are important determinants of exit rates. Moreover, in most cases, their effect on survival seems to persist without much of an attenuation for several years after the founding of the firm.
Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma: Occurence and prognostic significance

Purpose Targeted therapy represents an attractive alternative for rare tumors such as urachal carcinoma (UrC). The aim of this study was to assess the mutations of the most commonly affected 5 genes in the targetable EGFR-pathway in UrC and comapre their frequencies to those of found in urothelial and colorectal cancer. Materials and Methods Mutational hot-spots of selected genes were tested in 22 UrC samples by pyrosequencing. Mutational patterns were compared to those published for colorectal and urothelial cancers. Furthermore, we sought correlations between mutations and clinicopathological and follow-up data. Results We found 11 mutations in 10 of 22 (45%) patients. The most frequently mutated gene was KRAS (27%) followed by BRAF (18%) and NRAS (5%), while no mutations were detected in the EGFR and PIK3CA genes. No correlation was found between the mutation status and clinicopathological parameters (Sheldon/Mayo stage, tumor grade, metastases). Furthermore, none of the mutations correlated with progression-free or overall survival. Conclusions The mutation pattern of UrC is more similar to colorectal than to urothelial cancer. However, the mutation characteristics of UrC seems to be unique suggesting that clinical decision-making for UrC cannot be simply adopted from urothelial or colorectal carcinoma. The high occurence of EGFR-pathway mutations warrants the testing for KRAS and BRAF mutations when considering anti-EGFR therapy in UrC.
Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset

Diffusion MRI has been successful in identifying the existence of white matter abnormalities in schizophrenia in vivo. However, the role of these abnormalities in the etiology of schizophrenia is not well understood. Accumulating evidence from imaging, histological, genetic, and immunochemical studies support the involvement of axonal degeneration and neuroinflammation—ubiquitous components of neurodegenerative disorders—as the underlying pathologies of these abnormalities. Nevertheless, the current imaging modalities cannot distinguish neuroinflammation from axonal degeneration, and therefore provide little specificity with respect to the pathophysiology progression and whether it is related to a neurodegenerative process. Free-water imaging is a new methodology that is sensitive to water molecules diffusing in the extracellular space. Excessive extracellular volume is a surrogate biomarker for neuroinflammation and can be separated out to reveal abnormalities such as axonal degeneration that affect diffusion characteristics in the tissue. We applied free-water imaging on diffusion MRI data acquired from schizophrenia-diagnosed human subjects with a first psychotic episode. We found a significant increase in the extracellular volume in both white and gray matter. In contrast, significant signs of axonal degeneration were limited to focal areas in the frontal lobe white matter. Our findings demonstrate that neuroinflammation is more prominent than axonal degeneration in the early stage of schizophrenia, revealing a pattern shared by many neurodegenerative disorders, in which prolonged inflammation leads to axonal degeneration. These findings promote anti-inflammatory treatment for early diagnosed schizophrenia patients.
Pervasive Developmental Disorders and GABAergic System in Patients With Inverted Duplicated Chromosome 15

Pervasive developmental disorders are characterized by severe, pervasive impairment in several areas of development, with distorted communication skills and stereotypical behavior. Pervasive developmental disorders have a heterogeneous etiology related to brain damage, familial affective psychopathology, chromosomal abnormalities, or dysfunction of neuromodulators. Recently, it has been suggested that the GABRB3 gene, located within chromosome 15q11-13, is a candidate for pervasive developmental disorder. In inverted duplicated chromosome 15 syndrome, in which there is a small marker chromosome derived from inversion and duplication of the chromosome 15q11-q13 region, all patients present with pervasive developmental disorder. To further investigate a possible involvement of the γ-aminobutyoic acid (GABA)ergic system in the inverted duplicated chromosome 15 syndrome, we evaluated plasma levels of GABA and diazepam binding inhibitor in 6 patients with inverted duplicated chromosome 15 and in 8 subjects not affected by neurologic disease. Our findings do not seem to support this hypothesis as no significant differences were found in the GABA and diazepam binding inhibitor plasma levels between patients with inverted duplicated chromosome 15 and controls, but we must consider the possibility that a genetic abnormality of the GABA A receptor could be present in patients with inverted duplicated chromosome 15 and still not be reflected in an alteration in either GABA or diazepam binding inhibitor levels in plasma. (J Child Neurol 2001;16:911-914).
Effects of a Rehabilitation Program on Skeletal Muscle Function in Idiopathic Pulmonary Arterial Hypertension

INTRODUCTION: A majority of patients with idiopathic pulmonary arterial hypertension (IPAH) display persistent exercise intolerance despite current therapies. Whether a rehabilitation program elicits favorable changes in muscle function which would partly explain improvements in exercise tolerance of IPAH patients remains unknown. We performed this study to assess the effect of a 12-week rehabilitation program on skeletal muscle characteristics and exercise tolerance in patients with IPAH. METHODS: Exercise capacity measured by the 6-minute walk test and by the cycle endurance test (CET), limb muscle cross-sectional area, quadriceps function by maximal voluntary contraction and magnetic stimulation (potentiated twitches), and molecular muscle characteristics by quadriceps biopsy of 5 IPAH patients were assessed before and after a 12-week rehabilitation program. RESULTS: Following training, improvements in all patients were observed for the 6-minute walk test distance, from 441 (75) to 499 (85) m, P = . 01, and the CET time, from 429 (239) to 633 (380) seconds, P = . 16. Minute ventilation assessed at isotime during CET decreased by 15(11)%, P = . 05. This was related to both decreased carbon dioxide output and . These improvements were associated with decreased type IIx fiber proportion, 31(8)% to 23(10)%, P = . 05. DISCUSSION: Peripheral muscle characteristic improvements may contribute to the clinical benefit observed following a rehabilitation program in IPAH.
Why does relative deprivation affect mental health? The role of justice, trust and social rank in psychological wellbeing and paranoid ideation

Purpose – Relative deprivation is associated with poor mental health but the mechanisms responsible have rarely been studied. The purpose of this paper is to hypothesize that childhood perceived relative deprivation (PRD) would be linked to sub-syndromal psychotic symptoms and poor wellbeing via beliefs about justice, trust and social rank. Design/methodology/approach – In total, 683 undergraduate students were administered measures of childhood PRD, hallucination-proneness, paranoia and wellbeing and measures of trust, social rank and beliefs about justice. A subsample supplied childhood address data. Multiple mediation analysis was used to assess pathways from childhood experiences to outcomes. Findings – Childhood PRD was associated with all three outcomes. The relationship between PRD and paranoia was fully mediated by perceptions that the world is unjust for the self and low social rank. The same variables mediated the relationship between PRD and poor wellbeing. There were no significant mediators o.
Level of processing affects priming in word fragment completion.

In 4 experiments, Ss studied words under learning conditions that promoted semantic or physical processing. An implicit word fragment completion test was administered (e.g., complete 1 ph t for elephant). When semantic and physical study conditions were manipulated between Ss (Experiments 1 and 3) or within Ss in a blocked fashion (Experiments 3 and 4), significant levels of processing (LOP) effects were obtained. When semantic and physical conditions were presented in a mixed list (Experiments 2, 3, and 4), the LOP effect was smaller and not significant. A survey of the literature on LOP effects in implicit perceptual tests revealed that priming in these tests was consistently greater in the semantic than physical condition, with reports of statistically significant LOP effects
Clozapine in schizophrenia patients with recurrent catatonia: Report of two cases

Abstract Prolonged catatonia can be a source of extremely serious morbidity and mortality. Lorazepam is effective in rapidly relieving most cases of catatonia. Reports have also shown that second‐generation antipsychotic drugs are also efficacious in relieving catatonia. This report describes two schizophrenia patients who demonstrated recurrent catatonic features mutism and stupor. Both patients were treated with lorazepam, diazepam or electroconvulsive therapy (ECT). Patient 1 responded well and rapidly to lorazepam each time catatonia happened; but catatonia recurred once a year under treatment with many antipsychotic drugs. Patient 2 had catatonia features associated with discontinuing or decreasing clozapine. With each recurrent episode, the duration of catatonia increased, requiring an increased dosage of benzodiazepine. The patient's response to lorazepam and ECT gradually decreased, until the patient had almost no response to lorazepam, diazepam or ECT. Both patients had no recurrence during a period of 2‐year follow up with continuous clozapine therapy.
Dirtying Linen: Re‐evaluating the sustainability of domestic laundry

In tackling and negotiating responsibility for anthropogenic climate change, governments and businesses are increasingly concerned with shaping ‘consumer behaviour’, understood broadly as the ways in which people acquire, appropriate and appreciate goods and services. One intervention considered successful in this respect has been that of encouraging the low-temperature washing of laundry in the UK in the last decade. This paper draws on data from a quantitative survey of laundry practices conducted in Britain in 2013 (N = 1502) in order to situate the intervention, and the phenomenon of low-temperature washing, in its wider socio-cultural context. Our starting point is that laundry habits are a useful example of a household practice in which changes in consumer behaviour have occurred, yet which continue to be increasingly environmentally problematic. Our analysis examines the use of washing machines and the temperature at which people do their laundry in detail; however, it also explores the broader processes through which clothing and other items become designated ‘dirty’ and go on to become ‘clean’. We argue that, in contrast to the well-documented hegemonic position of the washing machine in UK homes, there is much diversity in how households organize the other tasks involved in doing laundry, particularly in separating, sorting and drying, with important implications for energy use. To conclude, we reconsider low-temperature washing as an intervention, and outline some policy implications of a more thorough understanding of how laundry, and domestic consumption more generally, is currently handled in the UK.
A Flexible Strain Sensor Based on a Conductive Polymer Composite for in situ Measurement of Parachute Canopy Deformation

A sensor based on a Conductive Polymer Composite (CPC), fully compatible with a textile substrate and its general properties, has been developed in our laboratory, and its electromechanical characterization is presented herein. In particular the effects of strain rate (from 10 to 1,000 mm/min) and of repeated elongation cycles on the sensor behaviour are investigated. The results show that strain rate seems to have little influence on sensor response. When submitted to repeated tensile cycles, the CPC sensor is able to detect accurately fabric deformations over each whole cycle, taking into account the mechanical behaviour of the textile substrate. Complementary information is given concerning the non-effect of aging on the global resistivity of the CPC sensor. Finally, our sensor was tested on a parachute canopy during a real drop test: the canopy fabric deformation during the critical inflation phase was successfully measured, and was found to be less than 9%.
Mental health and workplace bullying: The role of power, professions and ‘on the job’ training

Abstract Study of the professions, and the process of professionalisation as an occupational strategy, has mainly concentrated on investigating structures of power, rather than individual and deliberate use of power. This chapter provides a microanalysis of power relations by examining professional power and hierarchy in interpersonal relations within the workplace. It makes links across the spectrum of workplaces in which bullying occurs - from those where physical intimidation and threat of violence is experienced, to the professions and quasi-professions where legitimate power becomes the vehicle for invisible bullying practices. Arguably, it is within the professions that bullying occurs in its most rarefied form and, to understand the phenomenon, I argue that we should closely examine instances of workplace bullying where there is no one tangible or definable act but clearly an ongoing threat to an individual worker’s health and safety. In particular, I explore the positionality of the traditional professions within new organisational structures. The paper concludes with recommendations for the promotion of mental health at work that focus on both environmental and individual strategies.