Miracle-dz/UniFAR-FTUs huggingface dataset:
Gendered Discourses in Speech and Language Therapy

The Speech and Language Therapy (SLT) profession in the UK presents a striking example of ‘occupational sex segregation’: men make up only 2.5% of SLTs. This paper discusses parts of a research project which explored the gendered discourses that construct speech and language therapy as a gendered profession or as ‘women’s work’. Data were collected via questionnaires, interviews and focus groups with SLT graduates, Speech and Language Therapists, SLT teachers and careers advisors in London, UK. Data were analysed qualitatively using grounded theory principles, iterative thematic analysis and discourse analysis. The findings show that the gender imbalance (in terms of numbers) in this profession is shored up by a range of gendered discourses and their associated social practices: discourses of SLT as a gendered profession; gender differences discourses; discourses of women as ‘carers/ nurturers’ and as ‘superior communicators’; and discourses of gender and career progression. These discourses were sometimes taken as given and reinforced by research participants, while at other times they were contested. The research presented here constitutes a much-needed starting point in the investigation of an under-researched area, and aims to extend our understanding of the topic from a critical discursive perspective.
Hopelessness and Psychiatric Symptomatology in Hospitalized Physically Ill Adolescents

This study compares scores on psychiatric disturbance and hopelessness in two adolescent samples. The one sample was a physically ill hospitalized group, and the other was a matched group of healthy control subjects. It was found that the hospitalized physically ill group scored significantly higher on both psychiatric disturbance and hopelessness than the healthy group. At six-month follow-up, the physically ill group's scores on psychiatric disturbance had declined significantly, but hopelessness scores remained significantly high. In line with other findings, this study suggests that insufficient clinical attention is paid to psychiatric symptoms in hospitalized physically ill patients, and that the high hopelessness scores after six months warrant clinical psychological evaluation.
Dynamics of calling: a longitudinal study of musicians

The dominant view of calling among management scholars is that it is a stable construct that does not change. This view has resulted in a research void about calling's early development and subsequent evolution. Insight into the dynamic process through which callings develop is fundamental to understanding its role in people's careers and lives. In this study, I focus on the antecedents of calling, a consuming, meaningful passion people can experience toward a domain. I propose a dynamic model in which calling can change over time and can be shaped by antecedent factors, specifically, through people's ability, behavioral involvement, and social comfort in the area toward which they feel a calling. I tested these ideas in a seven-year, four-wave prospective longitudinal survey study of 450 amateur musicians. Multilevel analyses indicate individuals who were more behaviorally involved and felt higher social comfort in the calling domain (e.g., music) experienced higher levels of calling early on but experienced a decline in calling over time. Individuals' ability in the calling domain was not related to initial calling or change in calling. I discuss the implications for theory and research on calling, meaning of work, and the dynamics of careers. Copyright © 2012 John Wiley & Sons, Ltd.
Minority Journalism Student Academic Comparisons between Those with and Those without High School Print Media Experience

To better understand the worth of high school publications experiences, this study examines minority high school journalism students as compared with non-journalism minority students. Using data gathered in ACT pre-college standardized tests and results of collegiate performance, researchers found that journalism minority students outperformed non-journalism minority students in twelve of fifteen major academic comparisons. For this study, 5,369 minority students were studied from a national database. Of those, 993 (18.5%) had served on the staff of a high school newspaper or yearbook.
k-nearest neighbors in uncertain graphs

Complex networks, such as biological, social, and communication networks, often entail uncertainty, and thus, can be modeled as probabilistic graphs. Similar to the problem of similarity search in standard graphs, a fundamental problem for probabilistic graphs is to efficiently answer k-nearest neighbor queries (k-NN), which is the problem of computing the k closest nodes to some specific node. In this paper we introduce a framework for processing k-NN queries in probabilistic graphs. We propose novel distance functions that extend well-known graph concepts, such as shortest paths. In order to compute them in probabilistic graphs, we design algorithms based on sampling. During k-NN query processing we efficiently prune the search space using novel techniques. Our experiments indicate that our distance functions outperform previously used alternatives in identifying true neighbors in real-world biological data. We also demonstrate that our algorithms scale for graphs with tens of millions of edges.
A principle of hope: recorded music, listening practices and the immanence of utopia

In this paper I draw a set of partial connections between ways of using recorded music and utopia. The first half of the paper draws upon the process philosophy of Ernst Bloch to argue that utopia is not located else–where or else–when in a transcendent realm separate from the present but is paradoxically immanent to ‘everyday life’. This argument revolves around the novel ‘open’ experimental ontology that Bloch elaborates through the operator the ‘not–yet’. Bloch's work enables the beginnings of an immanent utopianism that is able to discern, rather than critique, the dimly vibrating figures of hope that exist within rather than outside ‘everyday life’. The second half of the paper sets this thought in motion by connecting two of Bloch's concepts, the ‘trace’ and ‘novum’, to the logic of one particularly common way of using recorded music: the use of music to ‘feel better’. Drawing on in–depth case study research with seventeen lower–middle–class households I describe how this practice enables people to momentarily enact two forms of hope that are both based around the geographies of affect and affection: how something better might feel and an ability to forget. I conclude by speculatively describing the practice of a Blochian ‘immanent utopianism’ that itself embodies ‘a principle of hope’.
Leverage and House-Price Dynamics in U.S. Cities

We use city-level data to analyze the relationship between homeowner borrowing patterns and house-price dynamics. Our principal finding is that in cities where a greater fraction of homeowners are highly leveraged-- i.e., have high loan-to-value ratios--house prices react more sensitively to city-specific shocks, such as changes in per-capita income. This finding is consistent with recent theories that emphasize the role of borrowing in shaping the behavior of asset prices.
Defying Muller’s Ratchet: Ancient Heritable Endobacteria Escape Extinction through Retention of Recombination and Genome Plasticity

ABSTRACT Heritable endobacteria, which are transmitted from one host generation to the next, are subjected to evolutionary forces that are different from those experienced by free-living bacteria. In particular, they suffer consequences of Muller’s ratchet, a mechanism that leads to extinction of small asexual populations due to fixation of slightly deleterious mutations combined with the random loss of the most-fit genotypes, which cannot be recreated without recombination. Mycoplasma-related endobacteria (MRE) are heritable symbionts of fungi from two ancient lineages, Glomeromycota (arbuscular mycorrhizal fungi) and Mucoromycotina. Previous studies revealed that MRE maintain unusually diverse populations inside their hosts and may have been associated with fungi already in the early Paleozoic. Here we show that MRE are vulnerable to genomic degeneration and propose that they defy Muller’s ratchet thanks to retention of recombination and genome plasticity. We suggest that other endobacteria may be capable of raising similar defenses against Muller’s ratchet.
Orientia tsutsugamushi Subverts Dendritic Cell Functions by Escaping from Autophagy and Impairing Their Migration

Background Dendritic cells (DCs) are the most potent antigen-presenting cells that link innate and adaptive immune responses, playing a pivotal role in triggering antigen-specific immunity. Antigen uptake by DCs induces maturational changes that include increased surface expression of major histocompatibility complex (MHC) and costimulatory molecules. In addition, DCs actively migrate to regional lymph nodes and activate antigen-specific naive T cells after capturing antigens. We characterize the functional changes of DCs infected with Orientia tsutsugamushi, the causative agent of scrub typhus, since there is limited knowledge of the role played by DCs in O. tsutsugamushi infection. Methodology/Principal Finding O. tsutsugamushi efficiently infected bone marrow-derived DCs and induced surface expression of MHC II and costimulatory molecules. In addition, O. tsutsugamushi induced autophagy activation, but actively escaped from this innate defense system. Infected DCs also secreted cytokines and chemokines such as IL-6, IL-12, MCP5, MIP-1α, and RANTES. Furthermore, in vitro migration of DCs in the presence of a CCL19 gradient within a 3D collagen matrix was drastically impaired when infected with O. tsutsugamushi. The infected cells migrated much less efficiently into lymphatic vessels of ear dermis ex vivo when compared to LPS-stimulated DCs. In vivo migration of O. tsutsugamushi-infected DCs to regional lymph nodes was significantly impaired and similar to that of immature DCs. Finally, we found that MAP kinases involved in chemotactic signaling were differentially activated in O. tsutsugamushi-infected DCs. Conclusion/Significance These results suggest that O. tsutsugamushi can target DCs to exploit these sentinel cells as replication reservoirs and delay or impair the functional maturation of DCs during the bacterial infection in mammals.
Inhibitory Phosphorylation of Glycogen Synthase Kinase-3 (GSK-3) in Response to Lithium

Glycogen synthase kinase-3 (GSK-3) is a critical, negative regulator of diverse signaling pathways. Lithium is a direct inhibitor of GSK-3 and has been widely used to test the putative role of GSK-3 in multiple settings. However, lithium also inhibits other targets, including inositol monophosphatase and structurally related phosphomonoesterases, and thus additional approaches are needed to attribute a given biological effect of lithium to a specific target. For example, lithium is known to increase the inhibitory N-terminal phosphorylation of GSK-3, but the target of lithium responsible for this indirect regulation has not been identified. We have characterized a short peptide derived from the GSK-3 interaction domain of Axin that potently inhibits GSK-3 activity in vitro and in mammalian cells and robustly activates Wnt-dependent transcription, mimicking lithium action. We show here, using the GSK-3 interaction domain peptide, as well as small molecule inhibitors of GSK-3, that lithium induces GSK-3 N-terminal phosphorylation through direct inhibition of GSK-3 itself. Reduction of GSK-3 protein levels, either by RNA interference or by disruption of the mouse GSK-3β gene, causes increased N-terminal phosphorylation of GSK-3, confirming that GSK-3 regulates its own phosphorylation status. Finally, evidence is presented that N-terminal phosphorylation of GSK-3 can be regulated by the GSK-3-dependent protein phosphatase-1·inhibitor-2 complex.
An empirical study on bug assignment automation using Chinese bug data

Bug assignment is an important step in bug life-cycle management. In large projects, this task would consume a substantial amount of human effort. To compare with the previous studies on automatic bug assignment in FOSS (Free/Open Source Software) projects, we conduct a case study on a proprietary software project in China. Our study consists of two experiments of automatic bug assignment, using Chinese text and the other non-text information of bug data respectively. Based on text data of the bug repository, the first experiment uses SVM to predict bug assignments and achieve accuracy close to that by human triagers. The second one explores the usefulness of non-text data in making such prediction. The main results from our study includes that text data are most useful data in the bug tracking system to triage bugs, and automation based on text data could effectively reduce the manual effort.
The Relationship of Promotion Focus, Need for Cognitive Closure, and Categorical Accessibility in American and Hong Kong Chinese University Students

Categorical accessibility is a cognitive factor that limits the extent of creative conceptual expansion. In the present study, we sought to establish the categorical accessibility norms in five conceptual domains among American and Hong Kong Chinese university students. In addition, we predicted that the tendency to access normatively inaccessible exemplars in a conceptual domain is positively related to the motivation to maximize the likelihood of attaining positive outcomes (promotion focus) and negatively related to the need for cognitive closure. We obtained the predicted relationships among both American and Hong Kong Chinese university students. These findings were discussed in terms of their implications for promoting creativity across cultures.
Attitude Formation Through Exploration

Little experimental research has investigated how attitudes are formed via direct personal experience within risky environments. This report summarizes the development of Treasure Island (TI), an attitude learning paradigm based on BeanFest. Two studies are reported: The first designed to compare the outcomes of TI with BeanFest; the second to show how a manipulation of risk predictability would affect attitude learning within the paradigm. Study 1 demonstrated sampling and learning asymmetries similar to those seen in BeanFest, although the magnitude of these asymmetries was attenuated by the opportunity for participants to landmark decisions. The manipulation of risk predictability in Study 2 led participants to seemingly form a less accurate representation of the underlying pay-off contingencies; however, a significant negative learning asymmetry did persist. The findings of this research (a) identify TI as a versatile paradigm for the investigation of attitude learning within risky environments and (b) confirm the robust nature of the negative learning asymmetry in contingent-learning settings; but (c) assert that care should be taken when generalizing the findings of BeanFest to ostensibly more variable contexts.
The aphrodisiac herb Carpolobia: A biopharmacological and phytochemical review

Any agent with the ability to provoke sexual desire in an individual is referred to as an aphrodisiac. Aphrodisiac plants are used in the management of erectile dysfunction (ED) in men. One such plant popular in West and Central Africa among the Pygmies of Cameroon, Ipassa of Garbon, and the Yoruba, Ibo, Efik and Ijaw peoples of Nigeria is Carpolobia. It is an accepted and commonly utilized herbal booster of libido. It is used to cure male infertility and to boosts libido thereby augmenting male sexual functions or it is used to induce penile erection, and enhance male virility. The chewing stick prepared from the stem and root of either Carpolobia alba (CA) or Carpolobia lutea (CL) is patronized because it boosts male sexual performance. The genus Carpolobia has over 14 species. The leaf essential oil contains a variety of terpenoids, while polyphenols and triterpenoid saponins have been isolated from the root and leaf extracts respectively. Other ethnomedicinal uses include curing of stomach ailments, rheumatism, fever, pains, insanity, dermal infection, venereal diseases; to promote child birth; and as a taeniafuge and vermifuge. In spite of its popularity, no scientific data reviewing the biopharmacological and phytochemical activities of Carpolobia exist to our knowledge. The aim of this work is to collate all available published scientific reports in the literature on Carpolobia in a review paper. In this review, an overview of the morphology, taxonomy, ethnomedicinal claims, geographical distribution, and structurally elucidated compounds that are secondary metabolites isolated and characterized from Carpolobia species is established. The pharmacological assays, phytochemical screenings, and toxicological reports are also reviewed.
VLSI Architectures for Layered Decoding for Irregular LDPC Codes of WiMax

We present a new multi-rate architecture for decoding irregular LDPC codes in IEEE 802.16e WiMax standard. The proposed architecture utilizes the value-reuse property of offset min-sum, block-serial scheduling of computations and turbo decoding message passing algorithm. The decoder has the following advantages: 55% savings in memory, reduction of routers by 50%, and increase of throughput by 2times when compared to the recent state-of-the-art decoder architectures.
Involvement of Both Phosphatidylinositol 3-Kinase and p44/p42 Mitogen-Activated Protein Kinase Pathways in the Short-Term Regulation of Pyruvate Kinase L by Insulin.

Pyruvate kinase L (PK-L) is a key regulatory enzyme of the hepatic glycolytic/gluconeogenic pathway that can be dephosphorylated and activated in response to insulin. However, the signaling cascades involved in this insulin effect have not been established. In this work we have investigated the potential involvement of phosphatidylinositol 3-kinase (PI 3-K) and p44/p42 mitogen-activated protein kinase (MAPK) pathways in the short-term modulation of PK-L by insulin in primary cultures of rat hepatocytes. Wortmannin, at a concentration of 100 nm, caused a marked inhibition of the PI 3-K/protein kinase B pathway, which became complete at 500 nm wortmannin. Likewise, wortmannin at 100 and 500 nm, elicited partial and total inhibitions of insulin-mediated activation of PK-L, respectively. However, this PI 3-K inhibitor also reduced insulin-mediated phosphorylation of p44/p42 MAPK in cultured rat hepatocytes, indicating that both the PI 3-K and MAPK pathways could be involved in PK-L activation by insulin. Thre.
A Comparative Pan-Genome Perspective of Niche-Adaptable Cell-Surface Protein Phenotypes in Lactobacillus rhamnosus

Lactobacillus rhamnosus is a ubiquitously adaptable Gram-positive bacterium and as a typical commensal can be recovered from various microbe-accessible bodily orifices and cavities. Then again, other isolates are food-borne, with some of these having been long associated with naturally fermented cheeses and yogurts. Additionally, because of perceived health benefits to humans and animals, numerous L. rhamnosus strains have been selected for use as so-called probiotics and are often taken in the form of dietary supplements and functional foods. At the genome level, it is anticipated that certain genetic variances will have provided the niche-related phenotypes that augment the flexible adaptiveness of this species, thus enabling its strains to grow and survive in their respective host environments. For this present study, we considered it functionally informative to examine and catalogue the genotype-phenotype variation existing at the cell surface between different L. rhamnosus strains, with the presumption that this might be relatable to habitat preferences and ecological adaptability. Here, we conducted a pan-genomic study involving 13 genomes from L. rhamnosus isolates with various origins. In using a benchmark strain (gut-adapted L. rhamnosus GG) for our pan-genome comparison, we had focused our efforts on a detailed examination and description of gene products for certain functionally relevant surface-exposed proteins, each of which in effect might also play a part in niche adaptability among the other strains. Perhaps most significantly of the surface protein loci we had analyzed, it would appear that the spaCBA operon (known to encode SpaCBA-called pili having a mucoadhesive phenotype) is a genomic rarity and an uncommon occurrence in L. rhamnosus. However, for any of the so-piliated L. rhamnosus strains, they will likely possess an increased niche-specific fitness, which functionally might presumably be manifested by a protracted transient colonization of the gut mucosa or some similar microhabitat.
Happiness: Lessons from a New Science

In this new edition of his landmark book, Richard Layard shows that there is a paradox at the heart of our lives. Most people want more income. Yet as societies become richer, they do not become happier. This is not just anecdotally true, it is the story told by countless pieces of scientific research. We now have sophisticated ways of measuring how happy people are, and all the evidence shows that on average people have grown no happier in the last fifty years, even as average incomes have more than doubled. In fact, the First World has more depression, more alcoholism and more crime than fifty years ago. This paradox is true of Britain, the United States, continental Europe, and Japan. What is going on? Now fully revised and updated to include developments since first publication, Layard answers his critics in what is still the key book in 'happiness studies'.
The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells

Background Vascular calcification is an indicator of elevated cardiovascular risk. Vascular smooth muscle cells (VSMCs), the predominant cell type involved in medial vascular calcification, can undergo phenotypic transition to both osteoblastic and chondrocytic cells within a calcifying environment. Methodology/Principal Findings In the present study, using in vitro VSMC calcification studies in conjunction with ex vivo analyses of a mouse model of medial calcification, we show that vascular calcification is also associated with the expression of osteocyte phenotype markers. As controls, the terminal differentiation of murine calvarial osteoblasts into osteocytes was induced in vitro in the presence of calcifying medium (containing ß-glycerophosphate and ascorbic acid), as determined by increased expression of the osteocyte markers DMP-1, E11 and sclerostin. Culture of murine aortic VSMCs under identical conditions confirmed that the calcification of these cells can also be induced in similar calcifying medium. Calcified VSMCs had increased alkaline phosphatase activity and PiT-1 expression, which are recognized markers of vascular calcification. Expression of DMP-1, E11 and sclerostin was up-regulated during VSMC calcification in vitro. Increased protein expression of E11, an early osteocyte marker, and sclerostin, expressed by more mature osteocytes was also observed in the calcified media of Enpp1−/− mouse aortic tissue. Conclusions/Significance This study has demonstrated the up-regulation of key osteocytic molecules during the vascular calcification process. A fuller understanding of the functional role of osteocyte formation and specifically sclerostin and E11 expression in the vascular calcification process may identify novel potential therapeutic strategies for clinical intervention.