Miracle-dz/UniFAR-FTUs huggingface dataset:
Spin memory effect for compact binaries in the post-Newtonian approximation

The spin memory effect is a recently predicted relativistic phenomenon in asymptotically flat spacetimes that become nonradiative infinitely far in the past and future. Between these early and late times, the magnetic-parity part of the time integral of the gravitational-wave strain can undergo a nonzero change; this difference is the spin memory effect. Families of freely falling observers around an isolated source can measure this effect, in principle, and fluxes of angular momentum per unit solid angle (or changes in superspin charges) generate the effect. The spin memory effect had not been computed explicitly for astrophysical sources of gravitational waves, such as compact binaries. In this paper, we compute the spin memory in terms of a set of radiative multipole moments of the gravitational-wave strain. The result of this calculation allows us to establish the following results about the spin memory: (i) We find that the accumulation of the spin memory behaves in a qualitatively different way from that of the displacement memory effect for nonspinning, quasicircular compact binaries in the post-Newtonian approximation: the spin memory undergoes a large secular growth over the duration of the inspiral, whereas for the displacement effect this increase is small. (ii) The rate at which the spin memory grows is equivalent to a nonlinear, but nonoscillatory and nonhereditary effect in the gravitational waveform that had been previously calculated for nonspinning, quasicircular compact binaries. (iii) This rate of build-up of the spin memory could potentially be detected by future gravitational-wave detectors by carefully combining the measured waveforms from hundreds of gravitational-wave detections of compact binaries.
Graft‐Versus‐Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell‐Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations

A substantial proportion of patients with acute graft‐versus‐host disease (aGVHD) respond to cell therapy with culture‐expanded human bone marrow mesenchymal stromal/stem cells (BM‐MSCs). However, the mechanisms by which these cells can ameliorate aGVHD‐associated complications remain to be clarified. We show here that BM‐MSC‐derived extracellular vesicles (EVs) recapitulated the therapeutic effects of BM‐MSCs against aGVHD. Systemic infusion of human BM‐MSC‐derived EVs prolonged the survival of mice with aGVHD and reduced the pathologic damage in multiple GVHD‐targeted organs. In EV‐treated GVHD mice, CD4+ and CD8+ T cells were suppressed. Importantly, the ratio of CD62L‐CD44+ to CD62L + CD44‐ T cells was decreased, suggesting that BM‐MSC‐derived EVs suppressed the functional differentiation of T cells from a naive to an effector phenotype. BM‐MSC‐derived EVs also preserved CD4 + CD25 + Foxp3+ regulatory T cell populations. In a culture of CD3/CD28‐stimulated human peripheral blood mononuclear cells with BM‐MSC‐derived EVs, CD3+ T cell activation was suppressed. However, these cells were not suppressed in cultures with EVs derived from normal human dermal fibroblasts (NHDFs). NHDF‐derived EVs did not ameliorate the clinical or pathological characteristics of aGVHD in mice, suggesting an immunoregulatory function unique to BM‐MSC‐derived EVs. Microarray analysis of microRNAs in BM‐MSC‐derived EVs versus NHDF‐derived EVs showed upregulation of miR‐125a‐3p and downregulation of cell proliferative processes, as identified by Gene Ontology enrichment analysis. Collectively, our findings provide the first evidence that amelioration of aGVHD by therapeutic infusion of BM‐MSC‐derived EVs is associated with the preservation of circulating naive T cells, possibly due to the unique microRNA profiles of BM‐MSC‐derived EVs. Stem Cells 2018;36:434–445
Anatomy of the Third-Party Web Tracking Ecosystem

The presence of third-party tracking on websites has become customary. However, our understanding of the third-party ecosystem is still very rudimentary. We examine third-party trackers from a geographical perspective, observing the third-party tracking ecosystem from 29 countries across the globe. When examining the data by region (North America, South America, Europe, East Asia, Middle East, and Oceania), we observe significant geographical variation between regions and countries within regions. We find trackers that focus on specific regions and countries, and some that are hosted in countries outside their expected target tracking domain. Given the differences in regulatory regimes between jurisdictions, we believe this analysis sheds light on the geographical properties of this ecosystem and on the problems that these may pose to our ability to track and manage the different data silos that now store personal data about us all.
A simple alternative to Generalized Procrustes Analysis: Application to sensory profiling data

A statistical method for analysing sensory profiling data obtained by means of fixed vocabulary or free choice profiling is discussed. The most interesting feature of this method is that it involves only simple statistical treatment and can therefore be performed using standard software packages. The outcomes of this method are compared to those of Generalized Procrustes Analysis on the basis of two data sets obtained respectively by means of fixed vocabulary and free choice profiling. A significance test is also discussed in order to assess whether the overall configuration of the products is meaningful. This significance test is based upon a simulation study involving the permutation procedure.
Impact of contaminated household environment on stunting in children aged 12–59 months in Burkina Faso

Background Stunting affects 165 million children worldwide, with repercussions on their survival and development. A contaminated environment is likely to contribute to stunting: frequent faecal-oral transmission possibly causes environmental enteropathy, a chronic inflammatory disorder that may contribute to faltering growth in children. This study's objective was to assess the effect of contaminated environment on stunting in Burkina Faso, where stunting prevalence is persistently high. Methods Panel study of children aged 1–5 years in Kaya. Household socioeconomic characteristics, food needs and sanitary conditions were measured once, and child growth every year (2011–2014). Using multiple correspondence analysis and 12 questions and observations on water, sanitation, hygiene behaviours, yard cleanliness and animal proximity, we constructed a ‘contaminated environment’ index as a proxy of faecal-oral transmission exposure. Analysis was performed using a generalised structural equation model (SEM), adjusting for repeat observations and hierarchical data. Results Stunting (<2 SD height-for-age) prevalence was 29% among 3121 children (median (IQR) age 36 (25–48) months). Environment contamination was widespread, particularly in rural and peri-urban areas, and was associated with stunting (prevalence ratio 1.30; p=0.008), controlling for sex, age, survey year, setting, mother's education, father's occupation, household food security and wealth. This association was significant for children of all ages (1–5 years) and settings. Lower contamination and higher food security had effects of comparable magnitude. Conclusions Environment contamination can be at least as influential as nutritional components in the pathway to stunting. There is a rationale for including interventions to reduce environment contamination in stunting prevention programmes.
Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment

Application of tumor genome sequencing has identified numerous loss-of-function alterations in cancer cells. While these alterations are difficult to target using direct interventions, they may be attacked with the help of the synthetic lethality (SL) approach. In this approach, inhibition of one gene causes lethality only when another gene is also completely or partially inactivated. The EPHB6 receptor tyrosine kinase has been shown to have anti-malignant properties and to be downregulated in multiple cancers, which makes it a very attractive target for SL applications. In our work, we used a genome-wide SL screen combined with expression and interaction network analyses, and identified the SRC kinase as a SL partner of EPHB6 in triple-negative breast cancer (TNBC) cells. Our experiments also reveal that this SL interaction can be targeted by small molecule SRC inhibitors, SU6656 and KX2-391, and can be used to improve elimination of human TNBC tumors in a xenograft model. Our observations are of potential practical importance, since TNBC is an aggressive heterogeneous malignancy with a very high rate of patient mortality due to the lack of targeted therapies, and our work indicates that FDA-approved SRC inhibitors may potentially be used in a personalized manner for treating patients with EPHB6-deficient TNBC. Our findings are also of a general interest, as EPHB6 is downregulated in multiple malignancies and our data serve as a proof of principle that EPHB6 deficiency may be targeted by small molecule inhibitors in the SL approach.
Tibial plateau levelling osteotomy implant removal: A retrospective analysis of 129 cases

Summary Objective: To evaluate a cohort of dogs undergoing tibial plateau levelling osteotomy (TPLO) implant removal to determine key clinical features, prevalence, and indications for implant removal. Methods: Medical records of dogs undergoing TPLO implant removal at a private referral practice (Dallas Veterinary Surgical Center) between 2004–2008 were reviewed. Patient signalment, implant type, presence of concurrent medical disease, surgeon, antibiotic use, aerobic bacterial culture result, and operative findings were recorded. Data were analyzed using paired t-test, Fisher’s exact test, and Wilcoxon-rank sum test. Statistical significance was set at p <0.05. Results: The TPLO implants were removed from 126 dogs (n = 129, 4.8% of TPLO procedures) during the study period. Average time interval from TPLO to implant removal was 16.0 ± 17.8 months. The most common clinical signs were the presence of an open wound (n = 80), draining tract (n = 64), and lameness (n = 59). Culture of tissue or fluid from the implant bed or implants was positive for bacterial growth in 95/115 cases. A significantly greater proportion of the implants removed were Slocum TPLO plates (n = 109 6.1%) when compared to other TPLO plate types (n = 20 2.3%) (p <0.0001). No association was identified between a positive bacterial culture and measured variables. Clinical significance: Local bacterial infection and clinical signs of inflammation were the most common reasons for TPLO implant removal. There may be an increased implant-associated complication rate for Slocum TPLO plates in the study population.
[Pattern analysis of tempo-spatial distribution of schistosomiasis in marshland epidemic areas in stage of transmission control].

OBJECTIVE To investigate the tempo-spatial patterns of schistosomiasis in Jiangling County, Hubei Province, so as to identify the risk areas and provide the scientific evidence in following intervention plans for marshland epidemic areas in the stage of transmission control. METHODS The schistosomiasis epidemiological data in Jiangling County from 2009 to 2013 together with the related geographical information were collected and analyzed. The tempo-spatial distribution patterns were analyzed by the spatial autocorrelation analysis and spatial clustering analysis. RESULTS The human infection rate was decreased from 2.15% in 2009 to 0.63% in 2013, which was the historically low level. The results of tempo-spatial analysis showed that there were spatial clustering effects in human schistosomiasis infection for each of the years. The values of spatial autocorrelation index Moran's I were statistically significant. Eighteen and thirty-five clusters were detected by using SatScan and FlexScan software, respectively. CONCLUSIONS From 2009 to 2013, the schistosomiasis endemic situation in Jiangling County presented a decline trend and reached the historical low level. The identified spatial clustering areas should be targeted as the prioritized areas for schistosomiasis control.
Electrophysiological Dissociation of Picture Versus Word Encoding: The Distinctiveness Heuristic as a Retrieval Orientation

Event-related potentials (ERPs) were used to investigate the neural processes underlying the distinctiveness heuristic a response mode in which participants expect to remember vivid details of an experience and make recognition decisions based on this metacognitive expectation. One group of participants studied pictures and auditory words; another group studied visual and auditory words. Studied and novel items were presented at test as words only, with all novel items repeating after varying lags. ERP differences were seen between the word and picture groups for both studied and novel items. For the novel items, ERP differences were largest in frontal and central midline electrodes. In separate analyses, the picture group showed the greatest ERP differences between item types in a parietally based component from 550 to 1000 msec, whereas the word group showed the greatest differences in a frontally based component from 1000 to 2000 msec. The authors suggest that the distinctiveness heuristic is a retrieval orientation that facilitates reliance upon recollection to differentiate between item types. Although the picture group can use this heuristic and its retrieval orientation on the basis of recollection, the word group must engage additional postretrieval processes to distinguish between item types, reflecting the use of a different retrieval orientation.
Inhibition of microRNA 128 promotes excitability of cultured cortical neuronal networks

Cultured neuronal networks monitored with microelectrode arrays (MEAs) have been used widely to evaluate pharmaceutical compounds for potential neurotoxic effects. A newer application of MEAs has been in the development of in vitro models of neurological disease. Here, we directly evaluated the utility of MEAs to recapitulate in vivo phenotypes of mature microRNA-128 (miR-128) deficiency, which causes fatal seizures in mice. We show that inhibition of miR-128 results in significantly increased neuronal activity in cultured neuronal networks derived from primary mouse cortical neurons. These results support the utility of MEAs in developing in vitro models of neuroexcitability disorders, such as epilepsy, and further suggest that MEAs provide an effective tool for the rapid identification of microRNAs that promote seizures when dysregulated.
A phenology of the evolution of endothermy in birds and mammals

Recent palaeontological data and novel physiological hypotheses now allow a timescaled reconstruction of the evolution of endothermy in birds and mammals. A three‐phase iterative model describing how endothermy evolved from Permian ectothermic ancestors is presented. In Phase One I propose that the elevation of endothermy – increased metabolism and body temperature (Tb) – complemented large‐body‐size homeothermy during the Permian and Triassic in response to the fitness benefits of enhanced embryo development (parental care) and the activity demands of conquering dry land. I propose that Phase Two commenced in the Late Triassic and Jurassic and was marked by extreme body‐size miniaturization, the evolution of enhanced body insulation (fur and feathers), increased brain size, thermoregulatory control, and increased ecomorphological diversity. I suggest that Phase Three occurred during the Cretaceous and Cenozoic and involved endothermic pulses associated with the evolution of muscle‐powered flapping flight in birds, terrestrial cursoriality in mammals, and climate adaptation in response to Late Cenozoic cooling in both birds and mammals. Although the triphasic model argues for an iterative evolution of endothermy in pulses throughout the Mesozoic and Cenozoic, it is also argued that endothermy was potentially abandoned at any time that a bird or mammal did not rely upon its thermal benefits for parental care or breeding success. The abandonment would have taken the form of either hibernation or daily torpor as observed in extant endotherms. Thus torpor and hibernation are argued to be as ancient as the origins of endothermy itself, a plesiomorphic characteristic observed today in many small birds and mammals.
Visual entropy: A new framework for quantifying visual information based on human perception

In recent years, how to quantify visualizations of an object and surface displayed in 3D space is now more prominent with a rapid increase in the demand for three-dimensional (3D) content. In order to measure the content information in terms of human visual perception, it is necessary to quantify the visual information in accordance with the human visual system. In this paper, we propose a framework for expressing visual information in bits termed visual entropy based on information theory. The visual entropy of 2D content (2DVE) is composed of texture entropy on the 2D surface and depth entropy based on the monocular cue. In addition to 2DVE, the visual entropy of 3D content (3DVE) includes the depth entropy based on the binocular cue. A series of simulations are conducted to demonstrate the effectiveness of visual entropy, including a performance trade-off between 2D and 3D visualizations measured according to the bitrate.
Microscopic Analysis and Quality Assessment of Induced Sputum From Children With Pneumonia in the PERCH Study

Abstract Background. It is standard practice for laboratories to assess the cellular quality of expectorated sputum specimens to check that they originated from the lower respiratory tract. The presence of low numbers of squamous epithelial cells (SECs) and high numbers of polymorphonuclear (PMN) cells are regarded as indicative of a lower respiratory tract specimen. However, these quality ratings have never been evaluated for induced sputum specimens from children with suspected pneumonia. Methods. We evaluated induced sputum Gram stain smears and cultures from hospitalized children aged 1–59 months enrolled in a large study of community-acquired pneumonia. We hypothesized that a specimen representative of the lower respiratory tract will contain smaller quantities of oropharyngeal flora and be more likely to have a predominance of potential pathogens compared to a specimen containing mainly saliva. The prevalence of potential pathogens cultured from induced sputum specimens and quantity of oropharyngeal flora were compared for different quantities of SECs and PMNs. Results. Of 3772 induced sputum specimens, 2608 (69%) had <10 SECs per low-power field (LPF) and 2350 (62%) had >25 PMNs per LPF, measures traditionally associated with specimens from the lower respiratory tract in adults. Using isolation of low quantities of oropharyngeal flora and higher prevalence of potential pathogens as markers of higher quality, <10 SECs per LPF (but not >25 PMNs per LPF) was the microscopic variable most associated with high quality of induced sputum. Conclusions. Quantity of SECs may be a useful quality measure of induced sputum from young children with pneumonia.
Detection rate and predictive factors of sessile serrated polyps in an organised colorectal cancer screening programme with immunochemical faecal occult blood test: the EQuIPE study (Evaluating Quality Indicators of the Performance of Endoscopy)

Objectives To assess detection rate and predictive factors of sessile serrated polyps (SSPs) in organised colorectal cancer (CRC) screening programmes based on the faecal immunochemical test (FIT). Design Data from a case series of colonoscopies of FIT-positive subjects were provided by 44 Italian CRC screening programmes. Data on screening history, endoscopic procedure and histology results, and additional information on the endoscopy centre and the endoscopists were collected, including the age-standardised and sex-standardised adenoma detection rate (ADR) of the individual endoscopists. The SSP detection rate (SSP-DR) was assessed for the study population. To identify SSP-predictive factors, multilevel analyses were performed according to patient/centre/endoscopist characteristics. Results We analysed 72 021 colonoscopies, of which 1295 presented with at least one SSP (SSP-DR 1.8%; 95% CI 1.7% to 1.9%). At the per-patient level, SSP-DR was associated with males (OR 1.35; 95% CI 1.17 to 1.54) and caecal intubation (OR 3.75; 95% CI 2.22 to 6.34), but not with the FIT round. The presence of at least one advanced adenoma was more frequent among subjects with SSPs than those without (OR 2.08; 95% CI 1.86 to 2.33). At the per-endoscopist level, SSP-DR was associated with ADR (third vs first ADR quartile: OR 1.55; 95% CI 1.03 to 2.35; fourth vs first quartile: OR 1.89; 95% CI 1.24 to 2.90). Conclusion The low prevalence of SSPs and the lack of association with the FIT round argue against SSP as a suitable target for FIT-based organised programmes. Strict association of SSP-DR with the key colonoscopy quality indicators, namely caecal intubation rate and high ADR further marginalises the need for SSP-specific quality indicators in FIT-based programmes.
Steinernema diaprepesi (Nematoda: Steinernematidae): Its Occurrence in Western Mexico and Susceptibility of Engorded Cattle Ticks Boophilus microplus (Acari: Ixodidae)

Jaime Molina-Ochoa1,4, Khuong B. Nguyen2, Martin Gonzalez-Ramirez1, Miguel Guadalupe Quintana-Moreno3, Roberto Lezama-Gutierrez1 and John E. Foster4 ^niversidad de Colima, Facultad de Ciencias Biologicas y Agropecuarias, Laboratorio de Nematologia Entomopatogena, Km. 40 autopista Colima-Manzanillo, Apartado Postal 36, Tecoman, Colima 28930, Mexico E-mail: jmolina@ucol.mx, jmolinal8@hotmail.com, mglezr@ucol.mx,rlezama32@hotmail.com
Measuring Best Practices for Workplace Safety, Health, and Well-Being: The Workplace Integrated Safety and Health Assessment

Objective: To present a measure of effective workplace organizational policies, programs, and practices that focuses on working conditions and organizational facilitators of worker safety, health and well-being: the workplace integrated safety and health (WISH) assessment. Methods: Development of this assessment used an iterative process involving a modified Delphi method, extensive literature reviews, and systematic cognitive testing. Results: The assessment measures six core constructs identified as central to best practices for protecting and promoting worker safety, health and well-being: leadership commitment; participation; policies, programs, and practices that foster supportive working conditions; comprehensive and collaborative strategies; adherence to federal and state regulations and ethical norms; and data-driven change. Conclusions: The WISH Assessment holds promise as a tool that may inform organizational priority setting and guide research around causal pathways influencing implementation and outcomes related to these approaches.
CD4+ and CD8+ CD28null T Cells Are Cytotoxic to Autologous Muscle Cells in Patients With Polymyositis

Inflammatory T cell infiltrates in the skeletal muscle tissue of patients with polymyositis are dominated by CD28‐negative effector (CD28null) T cells of both the CD4 and CD8 lineage. These cells are potentially cytotoxic, and the aim of the present study was to develop a fully autologous cell culture system in which to investigate the functional contribution of such CD28null T cells to myotoxicity.