Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the Effect of Personality, Internet Literacy, and Use Expectancies in Internet-Use Disorder: A Comparative Study between China and Germany

Research on Internet-use Disorder (IUD) has increased rapidly, indicating its clinical and global importance. Past studies suggested cultural diversity regarding the prevalence of an IUD, e.g., between Asian and European countries. Additionally, it was found that personality factors, Internet-related cognitions and specific competences seem to influence IUD tendencies, but research lacks in cultural comparative studies regarding these mechanisms. This study focuses on differences between Germany and China regarding the above-mentioned characteristics. German (n = 411; M = 20.70 years, SD = 3.34 years) and Chinese participants (n = 410; M = 20.72 years, SD = 2.65 years) answered the short Internet Addiction Test, Big Five Inventories, the Internet-use Expectancies Scale, as well as the Internet Literacy Questionnaire. The results revealed higher occurrence of IUD symptoms in China. Furthermore, Chinese participants scored significantly higher on neuroticism and agreeableness, whereas German participants scored higher on extraversion and openness. Compared to German participants, Chinese showed higher expectancies to avoid negative feelings online and to be positively reinforced. Regarding Internet literacy, German participants indicated higher skills concerning the reflection and critical analysis of online content, whereas Chinese showed higher expertise in producing and interacting online. Further, simple slope analyses indicated that certain Internet literacy domains were related differentially to IUD symptoms in Germany and China. While Chinese participants with higher reflective skills indicated highest IUD symptoms, reflective skills revealed no effect in Germany. Additionally, higher self-regulative skills correlated with lower IUD symptoms in the German, but not in the Chinese sample. The results give a hint to potential cultural differences regarding IUD, especially on the predictive and protective role of Internet literacy domains.
PHOTOSYNTHETIC AND HETEROTROPHIC IMPACTS OF NUTRIENT LOADING TO BLACKWATER STREAMS

Blackwater stream systems are the most abundant type of freshwater lotic system on the Coastal Plain of the eastern United States. Many of these ecosystems drain watersheds that receive large anthropogenic nutrient inputs, whereas some blackwater systems remain relatively pristine. A series of nutrient addition experiments was carried out over a four-year period to assess the roles of nitrogen and phosphorus loading on the phytoplankton, bacterioplankton, and respiration of two third-order and two fifth-order blackwater streams in southeastern North Carolina. Stream water was distributed into 4-L containers, amended with various nutrient addition treatments, and incubated in gently agitated outdoor pools over a six-day period. Chlorophyll a production, direct bacterial counts, ATP, and biochemical oxygen demand (BOD) were measured as response variables. Significant phytoplankton production over control occurred in most experiments involving nitrogen additions, regardless of whether it was in the form of a.
Maintenance of Genome Integrity by Mi2 Homologs CHD-3 and LET-418 in Caenorhabditis elegans

Meiotic recombination depends upon the tightly coordinated regulation of chromosome dynamics and is essential for the production of haploid gametes. Central to this process is the formation and repair of meiotic double-stranded breaks (DSBs), which must take place within the constraints of a specialized chromatin architecture. Here, we demonstrate a role for the nucleosome remodeling and deacetylase (NuRD) complex in orchestrating meiotic chromosome dynamics in Caenorhabditis elegans. Our data reveal that the conserved Mi2 homologs Chromodomain helicase DNA-binding protein (CHD-3) and its paralog LET-418 facilitate meiotic progression by ensuring faithful repair of DSBs through homologous recombination. We discovered that loss of either CHD-3 or LET-418 results in elevated p53-dependent germ line apoptosis, which relies on the activation of the conserved checkpoint kinase CHK-1. Consistent with these findings, chd-3 and let-418 mutants produce a reduced number of offspring, indicating a role for Mi2 in forming viable gametes. When Mi2 function is compromised, persisting recombination intermediates are detected in late pachytene nuclei, indicating a failure in the timely repair of DSBs. Intriguingly, our data indicate that in Mi2 mutant germ lines, a subset of DSBs are repaired by nonhomologous end joining, which manifests as chromosomal fusions. We find that meiotic defects are exacerbated in Mi2 mutants lacking CKU-80, as evidenced by increased recombination intermediates, corpses, and defects in chromosomal integrity. Taken together, our findings support a model wherein the C. elegans Mi2 complex maintains genomic integrity through reinforcement of a chromatin landscape suitable for homology-driven repair mechanisms.
A Quantitative Fourier Transform Infrared Study of the Grafting of Aminosilane Layers on Lithium Niobate Surface

Due to its impressive optical properties, lithium niobate (LiNbO3) is considered to be one of the most important ferroelectric materials. Its uses in sensing platforms require functionalization at the surface to enable the capture and quantifying of molecules. The current paper aims to demonstrate the covalent bonding of aminosilane layers to the LiNbO3 surface. Fourier transform infrared (FT-IR) analysis reveals the presence of an NbO–Si bond observable as a shoulder at the same wavenumber (975 cm−1) on the surfaces of LiNBO3 as well as on those of Nb2O5, using 3-(aminopropyl)trimethoxysilane (APTMS) or 3-(aminopropyl)methyldimethoxysilane (APDMS) precursors. This covalent bonding is confirmed by the insolubility of the silane coating in dimethyl sulfoxide (DMSO). A kinetic study of the aminosilane layer growth obtained by quantitative FT-IR analysis is also carried out.
Dietary Supplementation of Ascorbic Acid on Hemato-Biochemical and Hormonal Parameters in Swamp Buffaloes

Effect of ascorbic acid on hemato-biochemical and hormonal profile of swamp buffaloes were investigated during summer and post summer months. Eighteen swamp buffaloes (Avg. b.wt.336.24±10.27kg, age 3.5 years) were divided randomly into three groups of six each. The animals were supplemented with ascorbic acid (AA) at the rate of 0, 10 and 15 g/animal/day for 150 days and designated as T1 T2 and T3. Blood was collected on 0, 30th, 60th, 90th, 120th and 150th day of the experiment and analysed. Results indicated that the value of haemoglobin (Hb), Packed Cell Volume (PCV) and thyroxin was higher (p 0.05) higher while total leucocytic count (TLC), neutrophil, eosinophil, total protein, AST (Aspertate aminotransferase) and ALT (Alanine aminotransferase) was lower in T2 and T3 as compared to T1. Across the treatment T2 and T3 showed significantly (p<0.05) higher tri-iodothyronine and lymphocytes and (p<0.05) lower serum glucose and cortisol concentration as compared to T1. From this study, it is concluded that dietary supplementation of AA modulated hemato-biochemical and hormonal parameters in beneficial ways in swamp buffaloes to cope up thermal stress during summer and post summer months. The dose rate of AA 15 g/day/animal found to be more effective than 10 g/d/animal.
Comparison of Conventional Semen Parameters and Hypo-osmotic Swelling Test between Karan Fries and Sahiwal Bulls under Heat Stress

The present study aimed to determine the differences in semen parameters between Karan Fries (KF) and Sahiwal bulls and the correlation of hypo-osmotic swelling test with conventional semen parameters. A total of 24 ejaculates were collected from each breed and subsequently classified according to their mass activity. The semen samples were further examined for progressive motility, sperm viability, sperm concentration and hypo-osmotic swelling test (HOST). The percentage of hypo-osmotically swelled spermatozoa was higher (P 0.05) between the breeds. With respect to association between HOST and conventional semen parameters, HOST showed significant (P<0.01) positive correlation with progressive motility (%), sperm viability (%) and sperm concentration in both breeds. This study indicated the HOST as an effective method to test the fertility potential of semen samples for artificial insemination and zebu breeds ejaculates have more fertility potential as compared to crossbred ejaculates under heat stress.
An Autophagy-Independent Role for ATG41 in Sulfur Metabolism During Zinc Deficiency

The Zap1 transcription factor of Saccharomyces cerevisiae is a key regulator in the genomic responses to zinc deficiency. Among the genes regulated by Zap1 during zinc deficiency is the autophagy-related gene ATG41. Here, we report that Atg41 is required for growth in zinc-deficient conditions, but not when zinc is abundant or when other metals are limiting. Consistent with a role for Atg41 in macroautophagy, we show that nutritional zinc deficiency induces autophagy and that mutation of ATG41 diminishes that response. Several experiments indicated that the importance of ATG41 function to growth during zinc deficiency is not because of its role in macroautophagy, but rather is due to one or more autophagy-independent functions. For example, rapamycin treatment fully induced autophagy in zinc-deficient atg41Δ mutants but failed to improve growth. In addition, atg41Δ mutants showed a far more severe growth defect than any of several other autophagy mutants tested, and atg41Δ mutants showed increased Heat Shock Factor 1 activity, an indicator of protein homeostasis stress, while other autophagy mutants did not. An autophagy-independent function for ATG41 in sulfur metabolism during zinc deficiency was suggested by analyzing the transcriptome of atg41Δ mutants during the transition from zinc-replete to -deficient conditions. Analysis of sulfur metabolites confirmed that Atg41 is needed for the normal accumulation of methionine, homocysteine, and cysteine in zinc-deficient cells. Therefore, we conclude that Atg41 plays roles in both macroautophagy and sulfur metabolism during zinc deficiency.
Optimal Timing of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis

Objectives: Acute cholangitis mandates resuscitation, antibiotic therapy, and biliary decompression. Our aim was to define the optimal timing of endoscopic retrograde cholangiopancreatography (ERCP) for patients with acute cholangitis. Methods: Clinical data on all cases of cholangitis managed by ERCP were prospectively collected from September 2010 to July 2013. The clinical impact of the time to ERCP, defined as the time from presentation in the emergency department to the commencement of the ERCP, was determined. The primary outcome was length of hospitalization. Secondary outcomes included vasopressor use, endotracheal intubation, intensive care unit admission, and death. Results: ERCP was successful in 182 (92%) of 199 patients with cholangitis. Length of hospitalization was significantly longer for patients undergoing ERCP at ≥48 versus <48 hours (median 9.1 vs. 6.5 d, P=0.004) even though patients having ERCP at ≥48 hours were less sick as indicated by less frequent intensive care unit admission [odds ratio,0.3; 95% confidence interval (CI), 0.2-0.6]. Multivariate analysis revealed that hospitalization increased by 1.44 days for every day ERCP was delayed (P<0.001). Comparison of ERCP≥72 versus <72 hours revealed odds ratios of 2.6 (95% CI, 1.0-7.0) for vasopressor requirement and 3.6 (95% CI, 0.8-15.9) for mortality. Time to ERCP did not impact technical success or procedural adverse events. Conclusions: ERCP should be performed within 2 days of presentation as a delay of 48 or more hours is associated with disproportionate increase in hospital stay. Delay>72 hours is associated with additional adverse outcomes including hypotension requiring vasopressor support.
Probiotics for Modification of the Incidence or Severity of Respiratory Tract Infections.

Cristiana Nascimento-Carvalho (Bahia, Brazil) Ville Peltola (Turku, Finland) Emmanuel Roilides (Thessaloniki, Greece) Ira Shah (Mumbai, India) David Burgner (Melbourne, Australia) Kow-Tong Chen (Tainan,Taiwan) Luisa Galli (Florence, Italy) Steve Graham (Melbourne, Australia) George Syrogiannopoulos (Larissa, Greece) Tobias Tenenbaum (Mannhein, Germany) Marc Tebruegge (Southampton, UK) Marceline Tutu van Furth (Amsterdam, The Netherlands)
Inhibition in the face of emotion: Characterization of the spatial‐temporal dynamics that facilitate automatic emotion regulation

Emotion regulation mediates socio‐cognitive functions and is essential for interactions with others. The capacity to automatically inhibit responses to emotional stimuli is an important aspect of emotion regulation; the underlying neural mechanisms of this ability have been rarely investigated. Forty adults completed a Go/No‐go task during magnetoencephalographic (MEG) recordings, where they responded rapidly to either a blue or purple frame which contained angry or happy faces. Subjects responded to the target color in an inhibition (75% Go trials) and a vigilance condition (25% Go trials). As expected, inhibition processes showed early, sustained activation (200–450 ms) in the right inferior frontal gyrus (IFG). Emotion‐related inhibition processes showed greater activity with angry faces bilaterally in the orbital‐frontal gyri (OFG) starting at 225 ms and temporal poles from 250 ms, with right hemisphere dominance. The presence of happy faces elicited earlier activity in the right OFG. This study demonstrates that the timing of inhibition processes varies with the emotional context and that there is much greater activation in the presence of angry faces. It underscores the importance of the right IFG for inhibition processes, but the OFG in automatic emotion regulation.
Facilitating Anti-Cancer Combinatorial Drug Discovery by Targeting Epistatic Disease Genes

Due to synergistic effects, combinatorial drugs are widely used for treating complex diseases. However, combining drugs and making them synergetic remains a challenge. Genetic disease genes are considered a promising source of drug targets with important implications for navigating the drug space. Most diseases are not caused by a single pathogenic factor, but by multiple disease genes, in particular, interacting disease genes. Thus, it is reasonable to consider that targeting epistatic disease genes may enhance the therapeutic effects of combinatorial drugs. In this study, synthetic lethality gene pairs of tumors, similar to epistatic disease genes, were first targeted by combinatorial drugs, resulting in the enrichment of the combinatorial drugs with cancer treatment, which verified our hypothesis. Then, conventional epistasis detection software was used to identify epistatic disease genes from the genome wide association studies (GWAS) dataset. Furthermore, combinatorial drugs were predicted by targeting these epistatic disease genes, and five combinations were proven to have synergistic anti-cancer effects on MCF-7 cells through cell cytotoxicity assay. Combined with the three-dimensional (3D) genome-based method, the epistatic disease genes were filtered and were more closely related to disease. By targeting the filtered gene pairs, the efficiency of combinatorial drug discovery has been further improved.
Efficacy of Carboxymethyl Cellulose as Fat Replacer on the Processing and Storage Quality of Buffalo Mozzarella Cheese

Processing and storage (4 ± 1°C) quality of Low-fat buffalo mozzarella cheese (BMC) was evaluated with carboxymethyl cellulose (CMC) as fat replacer. Five treatments of BMC viz. Control full-fat cheese (6.0% milk fat; CFFC), Control low-fat cheese (<0.5% MF) without CMC (CLFC), Low-fat cheese with 0.2% CMC (LFC-1), 0.4% CMC (LFC-2) and 0.6% CMC (LFC-3) were comparatively evaluated. Melting time increased, whereas hardness and chewiness decreased with CMC in BMC. Sensory panellists awarded LFC-2 highest and lowest to LFC-3, however treated products at all selected levels were superior than CLFC. Oxidative and microbial stability was improved in LFC-2 than CFFC during storage. Results concluded that 0.4% CMC is optimum for the development of extended shelf life functional BMC.
Combination of hyaluronic acid, carmellose, and osmoprotectants for the treatment of dry eye disease

Background Dry Eye Disease (DED) is a multifactorial disease, with a high prevalence, that can have a great impact on the quality of life of patients. The first step of treatment includes the use of lacrimal substitutes composed of polymers, possible to associate osmoprotectant agents to the lacrimal substitutes. The aim of this article is to analyze the properties of the combination of hyaluronic acid (HA), carmellose, and osmoprotectors (Optava Fusion®; Allergan, Inc., Irvine, CA, USA) on DED. General considerations on the use of artificial tears are also proposed. Methods A group of ophthalmologists, experts in the management of the ocular surface, analyzed different aspects related to DED; among them, the use of artificial tears in general and the properties of the combination of HA, carmellose, and osmoprotectors, in particular, were discussed. A review of the literature was carried out, which included different articles published in Spanish, English, and French until April 2017. Conclusions DED is a common chronic pathology that usually requires sustained treatment. In addition, the combination of HA, carmellose, and osmoprotectors has proven to be effective in the treatment of symptoms and signs of dry eye by the synergistic action of all its components. This review provides key elements to help ophthalmologists who begin in the management of DED.
The relationship between perceived injustice and the working alliance: a cross-sectional study of patients with persistent pain attending multidisciplinary rehabilitation

Abstract Purpose: Accumulating research suggests that perceived injustice is a risk factor for adverse recovery following painful injury. Presently, however, little is known about the processes by which perceived injustice influences rehabilitation outcomes. It is plausible that perceived injustice and associated anger impact rehabilitation outcomes by compromising the quality of the therapeutic working alliance; however, research has not previously examined the relationship between perceived injustice and the working alliance. Therefore, the present study investigated the association between perceived injustice, anger, and the working alliance. Methods: Sixty-six patients with persistent pain following musculoskeletal injury participated in this study. All participants were enrolled in a standardized multidisciplinary rehabilitation programme. Participants completed self-report measures of perceived injustice, pain intensity, disability, anger intensity and regulation style, depressive symptoms, and a measure of the working alliance with their principal rehabilitation clinician. Each participant’s principal clinician also completed the working alliance measure. Results: Greater perceptions of injustice were associated with poorer client ratings of the working alliance. Results also showed that anger expression mediated the association between perceived injustice and the working alliance. Conclusion: Strategies to enhance the working alliance between rehabilitation professionals and clients with elevated levels of perceived injustice are needed. Implications for Rehabilitation Perceived injustice is associated with poor progress in rehabilitation programmes for people with musculoskeletal pain following injury. Perceived injustice is negatively associated with the quality of the therapeutic working alliance. Strategies to enhance the working alliance between rehabilitation professionals and clients with elevated levels of perceived injustice are needed.
Native voice, self-concept and the moral case for personalized voice technology

Abstract Purpose (1) To explore the role of native voice and effects of voice loss on self-concept and identity, and survey the state of assistive voice technology; (2) to establish the moral case for developing personalized voice technology. Methods This narrative review examines published literature on the human significance of voice, the impact of voice loss on self-concept and identity, and the strengths and limitations of current voice technology. Based on the impact of voice loss on self and identity, and voice technology limitations, the moral case for personalized voice technology is developed. Results Given the richness of information conveyed by voice, loss of voice constrains expression of the self, but the full impact is poorly understood. Augmentative and alternative communication (AAC) devices facilitate communication but, despite advances in this field, voice output cannot yet express the unique nuances of individual voice. The ethical principles of autonomy, beneficence and equality of opportunity establish the moral responsibility to invest in accessible, cost-effective, personalized voice technology. Conclusions Although further research is needed to elucidate the full effects of voice loss on self-concept, identity and social functioning, current understanding of the profoundly negative impact of voice loss establishes the moral case for developing personalized voice technology. Implications for Rehabilitation Rehabilitation of voice-disordered patients should facilitate self-expression, interpersonal connectedness and social/occupational participation. Proactive questioning about the psychological and social experiences of patients with voice loss is a valuable entry point for rehabilitation planning. Personalized voice technology would enhance sense of self, communicative participation and autonomy and promote shared healthcare decision-making. Further research is needed to identify the best strategies to preserve and strengthen identity and sense of self.