Miracle-dz/UniFAR-FTUs huggingface dataset:
A clinical and serologic comparison of standard and purified bivalent inactivated influenza vaccines.

The possible benefits of inactivated influenza vaccines have been limited in part by unwanted local and systemic reactions [1-4]. Such reactions might be decreased by further purification of vaccine [5]. To test this hypothesis, 2 bivalent inactivated influenza vaccines, one purified by zonal ultracentrifugation and the other prepared by the standard Sharples' centrifugation, were compared clinically and serologically in a double-blind field trial during September, 1967. Efficacy of vaccine was assessed during a wave of illness that was associated with type A2 influenza and occurred 3 months after vaccination.
Power quality of a voltage source converter in a smart grid

One objective of the smart grid is to produce clean energy through the use of Renewable Energy Sources (RES) such as wind turbines and photovoltaic cells. RES systems are usually interfaced to the grid using electronic power converters. However, these interfacing converters generate voltage and current harmonics at the converter terminal which are further transmitted to the rest of the smart grid. This paper presents and evaluates different factors that may affect the produced harmonics and reduce the quality of power on the smart grid. The factors are investigated first from the converter design specification such as the switching frequency, modulation index and the converter topology, then from the smart grid network characteristics. It clearly shows in detail the relation between these factors and the harmonics generated by the converters and how it affects the power quality of the smart grid. The RES system and smart grid was simulated using MATLAB Simulink™ and Plecs™ simulation tools.
Unfakeable Facial Configurations Affect Strategic Choices in Trust Games with or without Information about Past Behavior

Background Many human interactions are built on trust, so widespread confidence in first impressions generally favors individuals with trustworthy-looking appearances. However, few studies have explicitly examined: 1) the contribution of unfakeable facial features to trust-based decisions, and 2) how these cues are integrated with information about past behavior. Methodology/Principal Findings Using highly controlled stimuli and an improved experimental procedure, we show that unfakeable facial features associated with the appearance of trustworthiness attract higher investments in trust games. The facial trustworthiness premium is large for decisions based solely on faces, with trustworthy identities attracting 42% more money (Study 1), and remains significant though reduced to 6% when reputational information is also available (Study 2). The face trustworthiness premium persists with real (rather than virtual) currency and when higher payoffs are at stake (Study 3). Conclusions/Significance Our results demonstrate that cooperation may be affected not only by controllable appearance cues (e.g., clothing, facial expressions) as shown previously, but also by features that are impossible to mimic (e.g., individual facial structure). This unfakeable face trustworthiness effect is not limited to the rare situations where people lack any information about their partners, but survives in richer environments where relevant details about partner past behavior are available.
Finding patterns in blog shapes and blog evolution

Can we cluster blogs into types by considering their typical posting and linking behavior? How do blogs evolve over time? In this work we answer these questions, by providing several sets of blog and post features that can help distinguish between blogs. The first two sets of features focus on the topology of the cascades that the blogs are involved in, and the last set of features focuses on the temporal evolution, using chaotic and fractal ideas. We also propose to use PCA to reduce dimensionality, so that we can visualize the resulting clouds of points. We run all our proposed tools on the icwsm dataset. Our findings are that (a) topology features can help us distinguish blogs, like ‘humor’ versus ‘conservative’ blogs (b) the temporal activity of blogs is very non-uniform and bursty but (c) surprisingly often, it is self-similar and thus can be compactly characterized by the so-called bias factor (the ‘80’ in a recursive 80-20 distribution).
Elusive Copy Number Variation in the Mouse Genome

Background Array comparative genomic hybridization (aCGH) to detect copy number variants (CNVs) in mammalian genomes has led to a growing awareness of the potential importance of this category of sequence variation as a cause of phenotypic variation. Yet there are large discrepancies between studies, so that the extent of the genome affected by CNVs is unknown. We combined molecular and aCGH analyses of CNVs in inbred mouse strains to investigate this question. Principal Findings Using a 2.1 million probe array we identified 1,477 deletions and 499 gains in 7 inbred mouse strains. Molecular characterization indicated that approximately one third of the CNVs detected by the array were false positives and we estimate the false negative rate to be more than 50%. We show that low concordance between studies is largely due to the molecular nature of CNVs, many of which consist of a series of smaller deletions and gains interspersed by regions where the DNA copy number is normal. Conclusions Our results indicate that CNVs detected by arrays may be the coincidental co-localization of smaller CNVs, whose presence is more likely to perturb an aCGH hybridization profile than the effect of an isolated, small, copy number alteration. Our findings help explain the hitherto unexplored discrepancies between array-based studies of copy number variation in the mouse genome.
Robust Cuts Over Time: Combatting the Spread of Invasive Species with Unreliable Biological Control

Widespread accounts of the harmful effects of invasive species have stimulated both practical and theoretical studies on how the spread of these destructive agents can be contained. In practice, a widely used method is the deployment of biological control agents, that is, the release of an additional species (which may also spread) that creates a hostile environment for the invader. Seeding colonies of these protective biological control agents can be used to build a kind of living barrier against the spread of the harmful invader, but the ecological literature documents that attempts to establish colonies of biological control agents often fail (opening gaps in the barrier). Further, the supply of the protective species is limited, and the full supply may not be available immediately. This problem has a natural temporal component: biological control is deployed as the extent of the harmful invasion grows. How can a limited supply of unreliable biological control agents best be deployed over time to protect the landscape against the spread of a harmful invasive species? To explore this question we introduce a new family of stochastic graph vaccination problems that generalizes ideas from social networks and multistage graph vaccination. We point out a deterministic (1 - 1/e)-approximation algorithm for a deterministic base case studied in the social networks literature (matching the previous best randomized (1 -1/e) guarantee for that problem). Next, we show that the randomized (1 -1/e) guarantee (and a deterministic 1/2 guarantee) can be extended to our much more general family of stochastic graph vaccination problems in which vaccinations (a.k.a. biological control colonies) spread but may be unreliable. For the non-spreading vaccination case with unreliable vaccines, we give matching results in trees. Qualitatively, our extension is from computing “cuts over time” to computing “robust cuts over time. ” Our new family of problems captures the key tensions we identify for containing invasive species spread with unreliable biological control agents: a robust barrier is built over time with unreliable resources to contain an expanding invasion.
Wound infiltration for surgery

Wound infiltration with local anaesthetics is a simple, effective and inexpensive means of providing good analgesia for a variety of surgical procedures without any major side‐effects. In particular, local anaesthetic toxicity, wound infection and healing do not appear to be major considerations. The purpose of this review is to outline the existing literature on a procedure‐specific basis and to encourage a more widespread acceptance of the technique, ensuring that all layers are infiltrated in a controlled and meticulous manner.
Discrimination between Lumbar Intraspinal Stenosis and Foraminal Stenosis using Diffusion Tensor Imaging Parameters: Preliminary Results

Study Design Retrospective observational study. Purpose To examine fractional anisotropy (FA) values and apparent diffusion coefficient (ADC) values of damaged nerves to discriminate between lumbar intraspinal stenosis (IS) and foraminal stenosis (FS) using diffusion tensor imaging (DTI) Overview of Literature It is important in the selection of surgical procedure to discriminate between lumbar IS and FS, but such discrimination is difficult. Methods There were 9 cases of IS, 7 cases of FS, and 5 healthy controls. The regions of interest were established in the lumbar intraspinal zone (Iz), nerve root (N), and extraforaminal zone (Ez). The FA and ADC values were measured on the affected and unaffected sides of the nerves. The FA ratio and the ADC ratio were calculated as the affected side/unaffected side ×100 (%). Results In the Ez, the FA value was significantly lower in FS than in IS (p<0.01). FA ratio was significantly lower in FS than in IS for the Ez (p<0.01). In the Iz, the ADC value was significantly higher in IS than FS (p<0.01). ADC ratio was significantly higher in FS than in IS for the N and Ez (p<0.05). For the Ez, receiver operating characteristic analysis of parameters revealed that the FA values showed a higher accuracy for the diagnosis of FS than the ADC values, and the FA value cut-off value was 0.42 (sensitivity: 85.7%, false positive: 11.1%) and the FA ratio cut-off value was 83.9% (sensitivity: 85.7%, false positive: 22.2%). Conclusions The low FA value in the extraforaminal zone suggests the presence of foraminal stenosis. When the FA value and FA ratio cut-off value were established as 0.42 and 83.9%, respectively, the accuracy was high for the diagnosis of foraminal stenosis. It may be possible to use DTI parameters to help in the discrimination between IS and FS.
Identification of BDNF Sensitive Electrophysiological Markers of Synaptic Activity and Their Structural Correlates in Healthy Subjects Using a Genetic Approach Utilizing the Functional BDNF Val66Met Polymorphism

Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. Brain-derived neurotropic factor (BDNF) is key synaptogenic molecule and targeting synaptic repair through modulation of BDNF signalling has been suggested as a potential drug discovery strategy. The development of such “synaptogenic” therapies depend on the availability of BDNF sensitive markers of synaptic function that could be utilized as biomarkers for examining target engagement or drug efficacy in humans. Here we have utilized the BDNF Val66Met genetic polymorphism to examine the effect of the polymorphism and genetic load (i.e. Met allele load) on electrophysiological (EEG) markers of synaptic activity and their structural (MRI) correlates. Sixty healthy adults were prospectively recruited into the three genetic groups (Val/Val, Val/Met, Met/Met). Subjects also underwent fMRI, tDCS/TMS, and cognitive assessments as part of a larger study. Overall, some of the EEG markers of synaptic activity and brain structure measured with MRI were the most sensitive markers of the polymorphism. Met carriers showed decreased oscillatory activity and synchrony in the neural network subserving error-processing, as measured during a flanker task (ERN); and showed increased slow-wave activity during resting. There was no evidence for a Met load effect on the EEG measures and the polymorphism had no effects on MMN and P300. Met carriers also showed reduced grey matter volume in the anterior cingulate and in the (left) prefrontal cortex. Furthermore, anterior cingulate grey matter volume, and oscillatory EEG power during the flanker task predicted subsequent behavioural adaptation, indicating a BDNF dependent link between brain structure, function and behaviour associated with error processing and monitoring. These findings suggest that EEG markers such as ERN and resting EEG could be used as BDNF sensitive functional markers in early clinical development to examine target engagement or drug related efficacy of synaptic repair therapies in humans.
Tumor Cells Loaded with α-Galactosylceramide Induce Innate NKT and NK Cell-Dependent Resistance to Tumor Implantation in Mice1

Dendritic cells (DCs) loaded with α-galactosylceramide (α-GalCer) are known to be active APCs for the stimulation of innate NKT and NK cell responses in vivo. In this study, we evaluated the capacity of non-DCs to present α-GalCer in vitro and in vivo, particularly tumor cells loaded with α-GalCer (tumor/Gal). Even though the tumor cells lacked expression of CD40, CD80, and CD86 costimulatory molecules, the i.v. injection of tumor/Gal resulted in IFN-γ secretion by NKT and NK cells. These innate responses to tumor/Gal, including the induction of IL-12p70, were comparable to or better than α-GalCer-loaded DCs. B16 melanoma cells that were stably transduced to express higher levels of CD1d showed an increased capacity relative to wild-type B16 cells to present α-GalCer in vivo. Three different tumor cell lines, when loaded with α-GalCer, failed to establish tumors upon i.v. injection, and the mice survived for at least 6 mo. The resistance against tumor cells was independent of CD4 and CD8 T cells but dependent upon NKT and NK cells. Mice were protected from the development of metastases if the administration of live B16 tumor cells was followed 3 h or 3 days later by the injection of CD1dhigh-α-GalCer-loaded B16 tumor cells with or without irradiation. Taken together, these results indicate that tumor/Gal are effective APCs for innate NKT and NK cell responses, and that these innate immune responses are able to resist the establishment of metastases in vivo.
Image Processing for Error Concealment

Transmission of videos in error prone environments such as mobile communications, may lead to video corruption or loss so that received visual quality is degraded. Therefore, it is essential to implement efficient and low complexity error concealment methods which allow visually reducing the degradation caused by the missing information. The contribution of this work is to report the results of a comparative analysis of five temporal error concealment (TEC) techniques in critical situations, where the frames are corrupted with different errors pattern covering 50% of the image area. The results indicate, according to two similarity metrics (SAD-BM and SAD-OBM), that the 'Best motion vector neighbor' and 'Zero motion vector' are the best TEC options. These results could help in the development of a robust but simple TEC algorithm against several errors distribution. This could be valuable in mobile video applications in which user's video requests are becoming more and more demanding and therefore significant loss of information could be present due to node congestion or excessive delay.
Human-centered picture slideshow personalization for mobile devices

This paper presents a human-centered picture slideshow system for mobile users. In contrast to conventional ROIs (region-of-interest) detection based systems, we provide mobile users the freedom of personalizing ROIs in a convenient and effective way. Here, we import a simple human interaction, i.e., only a single click, to give a hint for users' ROIs. First, local saliency map (LSM) is generated, which considers not only multi-scale contrast, but also the self-correlation measure and central effect. Then a local fuzzy growing method is adopted to extract ROIs automatically based on LSM. Extensive experiments and user studies show the encouraging performance of the proposed system.
How Different are Immigrants? A Cross-Country and Cross-Survey Analysis of Educational Achievement

This paper examines differences in educational achievement between immigrants and natives in ten countries with a high population of immigrant pupils: Australia, Canada, France, Germany, the Netherlands, New Zealand, Sweden, Switzerland, the UK and the USA. The first step of the analysis shows how far countries differ regarding immigrants’ educational disadvantage. In a second step, the paper compares immigrants’ characteristics across countries focusing predominantly on socioeconomic status, language proficiency, immigrants’ time spent in the host country and patterns of school segregation. Using a regression framework the last step of the analysis investigates how far these determinants of educational achievement can explain immigrants’ educational disadvantage in the countries examined. The paper evaluates whether results found are robust across different sources of achievement data: the Trends in International Maths and Science Study (TIMSS), the Programme of International Student Assessment (PISA) and the Programme of International Reading Literacy Study (PIRLS).
Peach (Prunus persica) Endopolygalacturonase cDNA Isolation and mRNA Analysis in Melting and Nonmelting Peach Cultivars

Two distinct partial cDNAs, PRF1 and PRF3, similar in sequence to previously described polygalacturonases, were amplified from ripe peach (Prunus persica L. Batsch cv Flavorcrest) fruit cDNA by the polymerase chain reaction. PRF1-related RNA was present in fruit from early ripening at levels not detected by northern analysis. PRF3-related RNA was readily detectable in ripe fruit by northern analysis. PRF3 was used to isolate a cDNA with a complete open reading frame, PRF5, from a [lambda]ZAP II cDNA library prepared from poly(A)+ RNA of ripe peach fruit. PRF5 coded for a predicted protein of 393 amino acids with a molecular mass of 41,500 D. The derived amino acid sequence of PRF5 included a putative leader sequence of 23 amino acids, followed by a sequence that matched the N terminus of endopolygalacturonase protein purified from ripe peach fruit. By northern analysis, PRF3-related RNA was undetectable in firm, unripe Flavorcrest fruit. It appeared at low levels as a 1.7-kb transcript in fruit that had begun to ripen and soften and was very abundant in ripe fruit that had undergone the “melting” stage of softening. The marked increase in PRF3-related RNA levels took place over a period of less than 2 d at 20[deg]C and coincided with the climacteric peak in ethylene evolution. Levels of 1-aminocyclopropane-1-carboxylate oxidase-related RNA increased during ripening at a much earlier stage than levels of PRF3-related RNA. Lower levels of 1.7-kb RNA transcript were detected by PRF3 in ripe fruit of the melting cultivar Fragar, which are firmer than Flavorcrest fruit. In ripe fruit of the nonmelting cultivar Carolyn, PRF3 detected a 1.45-kb RNA transcript that was present at low levels. Transcripts of a peach polygalacturonase-related genomic sequence were not detected in ripening fruit.
In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene.

BACKGROUND Mutations in thin-filament proteins have been linked to hypertrophic cardiomyopathy, but it has never been demonstrated that variants identified in the TNNC1 (gene encoding troponin C) can evoke cardiac remodeling in vivo. The goal of this study was to determine whether TNNC1 can be categorized as an hypertrophic cardiomyopathy susceptibility gene, such that a mouse model can recapitulate the clinical presentation of the proband. METHODS AND RESULTS The TNNC1-A8V proband diagnosed with severe obstructive hypertrophic cardiomyopathy at 34 years of age exhibited mild-to-moderate thickening in left and right ventricular walls, decreased left ventricular dimensions, left atrial enlargement, and hyperdynamic left ventricular systolic function. Genetically engineered knock-in (KI) mice containing the A8V mutation (heterozygote=KI-TnC-A8V(+/-); homozygote=KI-TnC-A8V(+/+)) were characterized by echocardiography and pressure-volume studies. Three-month-old KI-TnC-A8V(+/+) mice displayed decreased ventricular dimensions, mild diastolic dysfunction, and enhanced systolic function, whereas KI-TnC-A8V(+/-) mice displayed cardiac restriction at 14 months of age. KI hearts exhibited atrial enlargement, papillary muscle hypertrophy, and fibrosis. Liquid chromatography-mass spectroscopy was used to determine incorporation of mutant cardiac troponin C (≈ 21%) into the KI-TnC-A8V(+/-) cardiac myofilament. Reduced diastolic sarcomeric length, increased shortening, and prolonged Ca(2+) and contractile transients were recorded in intact KI-TnC-A8V(+/-) and KI-TnC-A8V(+/+) cardiomyocytes. Ca(2+) sensitivity of contraction in skinned fibers increased with mutant gene dose: KI-TnC-A8V(+/+)>KI-TnC-A8V(+/-)>wild-type, whereas KI-TnC-A8V(+/+) relaxed more slowly on flash photolysis of diazo-2. CONCLUSIONS The TNNC1-A8V mutant increases the Ca(2+)-binding affinity of the thin filament and elicits changes in Ca(2+) homeostasis and cellular remodeling, which leads to diastolic dysfunction. These in vivo alterations further implicate the role of TNNC1 mutations in the development of cardiomyopathy.
Reducing effect of a Phaseolus vulgaris dry extract on operant self-administration of a chocolate-flavoured beverage in rats

Extracts from or derivatives of Phaseolus vulgaris beans reduce body weight and food intake, including highly palatable foods and fluids, in multiple rodent models of overeating and obesity. The present study was designed to assess whether a standardised P. vulgaris dry extract was effective in reducing also the operant self-administration of a chocolate-flavoured beverage. To this end, rats were initially trained to lever-press for a chocolate-flavoured beverage under a fixed ratio 10 schedule of reinforcement in daily 60 min sessions. Once lever-responding reached stable levels, the effect of a P. vulgaris dry extract on the number of lever-responses for the chocolate-flavoured beverage was determined. Pretreatment with 50, 200 and 500 mg (intragastric) P. vulgaris dry extract per kg produced an approximate 15, 35 and 40 % reduction, respectively, in lever-responding for the chocolate-flavoured beverage. These results indicate the capacity of a P. vulgaris preparation to reduce the reinforcing properties of a highly palatable fluid in rats.