Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Porous Baffles on the Energy Performance of Contact Tanks in Water Treatment

Three-dimensional numerical simulations are performed to evaluate the effect of porous baffles on the efficiency of water treatment contact tanks. A second-order accurate numerical model is employed for the solutions of unsteady flow and tracer transport through the porous baffles. The flow through the porous medium is characterized while using the Darcy-Forchheimer relationship. Large Eddy Simulation (LES) model is used to simulate the instantaneous mixing of the tracer in the chambers of the contact tank. Three different porosities are considered to evaluate the effect of porosity on the hydraulic and mixing efficiencies of the contact tank. Simulated time-averaged flow field shows that porous baffles that are placed at the entrance of each chamber could successfully mitigate short-circuiting and yield plug-flow conditions through the system for low porosities. Flow in the contact tank becomes laminar as the flow velocities decrease due to viscous effects and inertial resistance in the porous zone. For this case, the tracer is transported with bulk flow through the system and leaves the contact tank with a high peak seen in the Residence Time Distribution (RTD) plot. Porous layer increases the hydraulic efficiency of the conventional design from “poor” to “good” according to the baffling factor and increases the overall efficiency from “compromising” to “good” according to the AD index. Comparison of the performance of the porous layer with the previously developed slot-baffle design shows that the slot-baffle design increases the efficiency of the tank with increasing dispersion effects, whereas the porous design increases hydraulic efficiency and reduces the dispersion effects. While the porous design reduces energy efficiency by 33% due to a drastic increase in drag in the flow through porous zone, the slot-baffle design increases the energy efficiency of the conventional design by 67%.
Abdominal tuberculosis: a retrospective review of cases presenting to a UK district hospital.

INTRODUCTION Peterborough has one of the highest rates of tuberculosis in the East of England; ∼40% of TB treated locally is extra-pulmonary. AIM AND METHODS All adults diagnosed with abdominal tuberculosis (ATB) between January 2008 and September 2011 in Peterborough Hospitals were retrospectively evaluated with regard to their clinical history, investigation, management and outcomes. RESULTS In total, 17 patients diagnosed with ATB were reviewed. All the patients were from (or descended from) high-risk ethnic groups. Four had co-existing pulmonary TB. Intestinal and peritoneal TB were the most common findings. The most common clinical manifestations included abdominal pain (71%), weight loss (59%), diarrhoea (47%) and pyrexia (41%). Fifteen patients had samples sent for microbiological investigation; 1 (6%) was smear positive and 9 (53%) were culture positive. Two (12%) were isoniazid resistant. No rifampicin resistance was detected. Anti-tuberculous therapy was given for 6-12 months. In total, 16 (94%) patients completed the treatment; 1 patient died prior to regime completion (crude mortality: 6%). There was one reported case of pyrazinamide intolerance and two episodes of isoniazid intolerance. DISCUSSION ATB is a diagnostic challenge, especially in absence of lung involvement. It mimics other diseases and clinical presentation is usually non-specific, which may lead to diagnostic delay and development of complications. Extreme vigilance should be used when dealing with unexplained abdominal symptoms to ensure timely diagnosis of ATB. Early diagnosis with early anti-tuberculous therapy and surgical treatment are essential to ensure as positive an outcome as possible.
The HEMO Study: applicability and generalizability.

The 2002 Lasker Clinical Medical Research Award honoured Willem Kolff and Belding Scribner, whose seminal work changed kidney failure from a fatal to a treatable disease. What began as exploratory efforts to sustain life and relieve uraemic symptoms in selected patients now provides chronic life-saving replacement therapy to millions of people worldwide. Continued improvements in clinical expertise, accrued scientific information and technical advances have improved dialytic therapy and outcomes. Unfortunately, despite this encouraging trend, there remain significant differences in clinical practice and less than optimal patient outcomes. The annual mortality rate of dialysed patients, albeit variable among different countries, remains unacceptably high. Although medical comorbidities and late referral of patients to nephrologists may contribute to this high mortality rate, the dialytic prescription can also influence mortality. To address this latter concern, national guidelines for dialysis therapy have been developed, but are based, to a great extent, on observational studies and registry data. There have been two randomized clinical trials of the dialysis prescription on outcomes in haemodialysis patients. The first, the National Cooperative Dialysis Study (NCDS), completed >20 years ago, established the importance of dialysis dose in affecting patient outcomes at dose levels substantially below current standards [1,2]. Subsequently, a large number of reports, from observational data sets, suggested that a dose of dialysis substantially higher than that provided in the NCDS trial is associated with a lower mortality rate [3–6]. In response to these observational studies, national standards for dialysis dose were developed in the United States advocating a minimum single pool Kt/V urea (spKt/V) of at least 1.2 [7]. The second randomized clinical trial, the Hemodialysis (HEMO) Study, begun in 1995, was designed to determine whether further increases in dialysis dose above current standards or the use of high-flux membranes would improve patient outcomes. The main results of the HEMO Study, published in December 2002 [8], showed no statistically significant effects by the two study interventions examined, dialysis dose and membrane flux, on mortality rates or on intermediate composite outcomes defined by time to either death or selected first cause-specific hospitalizations. Since the publication of this report, several articles have appeared which discuss the implications of the HEMO Study results for clinical practice, including generalizability, statistical power and design [9,10]. The goal of this report is to address the major questions that have been raised pending the publication of additional analyses of HEMO Study data.
KIN241: a gene involved in cell morphogenesis in Paramecium tetraurelia reveals a novel protein family of cyclophilin–RNA interacting proteins (CRIPs) conserved from fission yeast to man

In this study, we report cloning, by functional complementation of the KIN241 gene involved in Paramecium cell morphogenesis, cortical organization and nuclear reorganization. This gene is predicted to encode a protein of a novel type, comprising a cyclophilin‐type, peptidyl‐prolyl isomerase domain, an RNA recognition motif, followed by a region rich in glutamate and lysine (EK domain) and a C‐terminal string of serines. As homologues of this protein are present in the genomes of Schizosaccharomyces pombe, Caenorhabditis elegans, Drosophila melanogaster, Arabidopsis thaliana and Homo sapiens, the Kin241p predicted sequence defines a new family of proteins that we propose to call ‘CRIP’, for cyclophilin–RNA interacting protein. We demonstrate that, in Paramecium, Kin241p is localized in the nucleus and that deletion of some nuclear localization signals (NLSs) decreases transport of the protein into the nucleus. No Kin241‐1 protein is present in mutant cells, suggesting that the C‐terminal serine‐rich region is responsible for protein stability.
Sharpshooting suburban white-tailed deer reduces deer-vehicle collisions

Too many deer-vehicle collisions (DVCs) are one of the primary reasons local governments implement lethal deer management programs. However, there are limited data to demonstrate that a reduction in deer (Odocoileus spp.) densities will result in a decline in DVCs. We conducted sharpshooting programs in 3 suburban communities to reduce deer numbers and to address rising DVCs. Annual or periodic population estimates were conducted using both helicopter snow counts and aerial infrared counts to assess population trends. Management efforts were conducted from 3 to 7 years. Local deer herds were reduced by 54%, 72%, and 76%, with resulting reductions in DVCs of 49%, 75%, and 78%, respectively. These projects clearly demonstrate that a reduction in local deer densities using lethal methods can signifi cantly reduce DVCs.
Outcome of Sex Reassignment Surgery for Transsexuals*

Fifteen years ago the author reviewed the world literature on male transsexualism (Pauly, 1965). Subsequently he summarized the results of sex reassignment surgery for male and female transsexuals (Pauly, 1968), and reviewed the literature on female transsexualism (Pauly, 1974). Very recently, Meyer and Reter (1979) concluded that ‘sex reassignment surgery confers no objective advantage in terms of social rehabilitation’ as compared with a group of individuals who sought sex reassignment but remained unoperated upon at follow-up. Both groups improved over time and led the Johns Hopkins Gender Identity Clinic to conclude that sex reassignment surgery would no longer be offered there. This report, and other non-surgical, psychotherapeutic approaches to gender dysphoric patients (Barlow et al. 1973; Barlow et al. 1979; Lothstein and Levine, 1980) call into question the justification for sex reassignment surgery. Therefore, it becomes important to update the results of sex reassignment surgery for transsexuals. Data on 283 male to female transsexuals and 83 female to male transsexuals are presented.
Integration of complex larval chemosensory organs into the adult nervous system of Drosophila

The sense organs of adult Drosophila, and holometabolous insects in general, derive essentially from imaginal discs and hence are adult specific. Experimental evidence presented here, however, suggests a different developmental design for the three largely gustatory sense organs located along the pharynx. In a comprehensive cellular analysis, we show that the posteriormost of the three organs derives directly from a similar larval organ and that the two other organs arise by splitting of a second larval organ. Interestingly, these two larval organs persist despite extensive reorganization of the pharynx. Thus, most of the neurons of the three adult organs are surviving larval neurons. However, the anterior organ includes some sensilla that are generated during pupal stages. Also, we observe apoptosis in a third larval pharyngeal organ. Hence, our experimental data show for the first time the integration of complex, fully differentiated larval sense organs into the nervous system of the adult fly and demonstrate the embryonic origin of their neurons. Moreover, they identify metamorphosis of this sensory system as a complex process involving neuronal persistence, generation of additional neurons and neuronal death. Our conclusions are based on combined analysis of reporter expression from P[GAL4] driver lines, horseradish peroxidase injections into blastoderm stage embryos, cell labeling via heat-shock-induced flip-out in the embryo, bromodeoxyuridine birth dating and staining for programmed cell death. They challenge the general view that sense organs are replaced during metamorphosis.
The Formation of Collective Silk Balls in the Spider Mite Tetranychus urticae Koch

Tetranychus urticae is a phytophagous mite that forms colonies of several thousand individuals. These mites construct a common web to protect the colony. When plants become overcrowded and food resources become scarce, individuals gather at the plant apex to form a ball composed of mites and their silk threads. This ball is a structure facilitating group dispersal by wind or animal transport. Until now, no quantitative study had been done on this collective form of migration. This is the first attempt to understand the mechanisms that underlie the emergence and growth of the ball. We studied this collective behaviour under laboratory conditions on standardized infested plants. Our results show that the collective displacement and the formation of balls result from a recruitment process: by depositing silk threads on their way up to the plant apex, mites favour and amplify the recruitment toward the balls. A critical threshold (quorum response) in the cumulative flow of mites must be reached to observe the emergence of a ball. At the beginning of the balls formation, mites form an aggregate. After 24 hours, the aggregated mites are trapped inside the silk balls by the complex network of silk threads and finally die, except for recently arrived individuals. The balls are mainly composed of immature stages. Our study reconstructs the key events that lead to the formation of silk balls. They suggest that the interplay between mites' density, plant morphology and plant density lead to different modes of dispersions (individual or collective) and under what conditions populations might adopt a collective strategy rather than one that is individually oriented. Moreover, our results lead to discuss two aspects of the cooperation and altruism: the importance of Allee effects during colonization of new plants and the importance of the size of a founding group.
Effect of artificial structuring on the use of laying hen runs in a free-range system

1. This study examined whether a free range with roofed boxes with sand to structure the hen run had an effect on the numbers of hens going outside and on the distribution of the hens in the hen run. 2. On a poultry farm with 8 flocks of laying hens of roughly 500 birds per flock, each flock was observed with and without roofed boxes with sand. 3. There was no difference in the number of hens on free range with and without roofed boxes but there was an influence on the distribution. 4. In free range with structures there was a higher percentage of the hens outside in the furthest quarter where the structures were located. 5. We conclude that structures in the free range have an effect on the distribution of laying hens.
Effects of clinical, laboratuary and pathological features on successful sperm retrieval in non-obstructive azoospermia.

OBJECTIVE The study aims to evaluate the correlation of testicular sperm extraction (TESE) and histopathology with various features of non-obstructive azoospermia (NOA) cases who consulted to our university-based infertility clinic, and the probability of prompting couples about TESE success and to investigate the cost reduction chance through cost-beneficial aspects. MATERIAL AND METHODS One hundred and twenty-five patients were enrolled in this study. Age, unprotected intercourse period, age of puberty, and concomittant diseases were noted. Testicular volumes were measured. The correlations between genetic test results and serum levels of Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), free testosterone, prolactine were investigated. RESULTS The incidence of NOA among infertile men was found to be 15.1%. Median age of the cases was 33.1 years. Decrease in TESE success rate was seen in the group aged >30, and those who practiced unprotected intercourse for more than 10 years. TESE success rate was 40 percent. The required negative correlation between FSH levels, and testicular volume was not observed when the patient had additional diseases and/or genitourinary surgery. FSH and LH levels were significantly different between TESE- positive and negative groups (p=0.006, and p=0.001 respectively). Success rate in bilateral TESE group was 14.2%, and 96% of TESE- negative patients had bilateral TESE. Fifteen of 118 patients had Y chromosome microdeletions. These results were similar in both TESE- positive and negative group. CONCLUSION None of the parameters investigated herein predicted succesful TESE outcomes. However, in cases with increased FSH and AZFa/AZFb deletion before application of bilateral TESE, in cases of increased FSH and AZFa/AZFb deletion, detailed information should be given to these patients about low success rates and risk of disease inheritance which may reduce procedural costs. Knowing groups with poor prognosis, may help rearrangement of the appropriation of infertility in health policies.
Biocleaning to Remove Graffiti: A Real Possibility? Advances towards a Complete Protocol of Action

The first academic studies on the use of microorganisms in cleaning procedures appeared in the late 1980s/early 1990s. In the past thirty years, most of such studies have addressed the removal of nitrate and sulphate salts and organic matter from surfaces by using non-pathogenic anaerobic microorganisms, mainly sulphate-reducing bacteria. The successful use of microbes in the removal of graffiti paint remains, however, a work in progress. Biocleaning surfaces to remove graffiti is not a simple task, because of the complex chemical composition of graffiti paints. This study looks at ways of improving the bioremoval of graffiti and presents the latest findings regarding different methodological aspects of cleaning natural and man-made stone. Granite and concrete substrates were coated with silver and black graffiti spray paints for comparison of the efficacy of the biocleaning method on these different materials. Visual and microscopic examination along with colour and infrared measurements made after application of the bacterial strains tested (previously shown to be suitable candidates for bioremoval of graffiti) revealed remarkably successful results. The findings presented thus represent progress in the development of a biocleaning protocol applicable to the in-situ removal of graffiti. Important improvements have been made regarding the time of treatment, which has been reduced by up to 20 days, and the use of a culture medium enriched with powdered graffiti, which facilitates and accelerates the adaptation of the microorganisms to the target surface.
Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space

We manually defined the inferior frontal gyrus (IFG) on high‐resolution MRIs in native space in 30 healthy subjects (15 female, median age 31 years; 15 male, median age 30 years), resulting in 30 individual atlases. Using standard software (SPM99), these were spatially transformed to a widely used stereotaxic space (MNI/ICBM 152) to create probabilistic maps. In native space, the total IFG volume was on average 5%, and the gray matter (GM) portion 12% larger in women (not significant). Expressed as a percentage of ipsilateral frontal lobe volume (i.e., correcting for brain size), the IFG was an average of 20%, and the GM portion of the IFG 27%, larger in women (P < 0.005). Correcting for total lobar volume yielded the same result. No asymmetry was found in IFG volumes. There were significant positional differences between the right and left IFGs, with the right IFG being further lateral in both native and stereotaxic space. Variability was similar on the left and right, but more pronounced anteriorly and superiorly. We show differences in IFG volume, composition, and position between sexes and between hemispheres. Applications include probabilistic determination of location in group studies, automatic labeling of new scans, and detection of anatomical abnormalities in patients. Hum Brain Mapp, 2007. © 2006 Wiley‐Liss, Inc.
Toward technology-supported surgical training: the potential of virtual simulators in laparoscopic surgery

Background and Aims: The mastery of manual skills that are indispensable for the performance of surgical tasks is a competence specific to surgery. One way of facilitating this acquisition is to move the training out of the operating room and all of its restrictions. Surgical training out of the operating room, also called simulation, has spread widely in the past decade, especially in laparoscopic and endoscopic surgery. Material and Methods: This review assesses the role of virtual reality (VR) simulators in laparoscopic surgery and their actual impact on technical skills. Results and Conclusions: There is a wealth of simulators, ranging from low- to high-fidelity simulators incorporating haptic feedback. They comprise basic tasks, procedural modules, and full procedures. Virtual reality simulators have shown acceptable fidelity and validity evidence. Moreover, training out of the operating room on virtual reality simulators has demonstrated its positive impact on basic skills during real laparoscopic procedures in patients. The benefit of virtual reality over simple video trainers remains unclear for teaching basic skills. However, virtual reality simulators provide automatic feedback that permitted to design structured competency-based curricula and allow deliberate practice. Finally, advanced procedures and patient-specific models have been designed on virtual reality simulators, and further investigations are still awaited to appraise their educational value.
Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts

Plasma fibronectin binds saturably and reversibly to substrate-attached fibroblasts and is subsequently incorporated into the extracellular matrix (McKeown-Longo, P.J., and D. F. Mosher, 1983, J. Cell Biol., 97:466-472). We examined whether fragments of fibronectin are processed in a similar way. The amino-terminal 70,000-mol-wt catheptic D fragment of fibronectin bound reversibly to cell surfaces with the same affinity as intact fibronectin but did not become incorporated into extracellular matrix. The 70,000-mol-wt fragment blocked binding of intact fibronectin to cell surfaces and incorporation of intact fibronectin into extracellular matrix. Binding of the 70,000-mol-wt fragment to cells was partially abolished by cleavage into 27,000-mol- wt heparin-binding and 40,000-mol-wt gelatin-binding fragments and more completely abolished by reduction and alkylation of disulfide bonds. Binding of the 70,000-mol-wt fragment to cells was not blocked by gelatin or heparin. When coated onto plastic, the 70,000-mol-wt fragment did not mediate attachment and spreading of suspended fibroblasts. Conversely, fibronectin fragments that had attachment and spreading activity did not block binding of exogenous fibronectin to substrate-attached cells. These results indicate that there is a cell binding site in the 70,000-mol-wt fragment that is distinct from the previously described cell attachment site and is required for assembly of exogenous fibronectin into extracellular matrix.
Klf1, a C2H2 Zinc Finger-Transcription Factor, Is Required for Cell Wall Maintenance during Long-Term Quiescence in Differentiated G0 Phase

Fission yeast, Schizoaccharomyces pombe, is a model for studying cellular quiescence. Shifting to a medium that lacks a nitrogen-source induces proliferative cells to enter long-term G0 quiescence. Klf1 is a Krüppel-like transcription factor with a 7-amino acid Cys2His2-type zinc finger motif. The deletion mutant, ∆klf1, normally divides in vegetative medium, but proliferation is not restored after long-term G0 quiescence. Cell biologic, transcriptomic, and metabolomic analyses revealed a unique phenotype of the ∆klf1 mutant in quiescence. Mutant cells had diminished transcripts related to signaling molecules for switching to differentiation; however, proliferative metabolites for cell-wall assembly and antioxidants had significantly increased. Further, the size of ∆klf1 cells increased markedly during quiescence due to the aberrant accumulation of Calcofluor-positive, chitin-like materials beneath the cell wall. After 4 weeks of quiescence, reversible proliferation ability was lost, but metabolism was maintained. Klf1 thus plays a role in G0 phase longevity by enhancing the differentiation signal and suppressing metabolism for growth. If Klf1 is lost, S. pombe fails to maintain a constant cell size and normal cell morphology during quiescence.