Miracle-dz/UniFAR-FTUs huggingface dataset:
Solid Lymph Nodes as an Imaging Biomarker for Risk Stratification in Human Papillomavirus–Related Oropharyngeal Squamous Cell Carcinoma

BACKGROUND AND PURPOSE: Human papillomavirus–related oropharyngeal squamous cell carcinoma is associated with cystic lymph nodes on CT and has a favorable prognosis. A subset of patients with aggressive disease experience treatment failure. Our aim was to determine whether the extent of cystic lymph node burden on staging CT can serve as an imaging biomarker to predict treatment failure in human papillomavirus–related oropharyngeal squamous cell carcinoma. MATERIALS AND METHODS: We identified patients with human papilloma virus–related oropharyngeal squamous cell carcinoma and staging neck CTs. Demographic and clinical variables were recorded. We retrospectively classified the metastatic lymph node burden on CT as cystic or solid and assessed radiologic extracapsular spread. Biopsy, subsequent imaging, or clinical follow-up was the reference standard for treatment failure. The primary end point was disease-free survival. Cox proportional hazard regression analyses of clinical, demographic, and anatomic variables for treatment failure were performed. RESULTS: One hundred eighty-three patients were included with a mean follow-up of 38 months. In univariate analysis, the following variables had a statistically significant association with treatment failure: solid-versus-cystic lymph nodes, clinical T-stage, clinical N-stage, and radiologic evidence of extracapsular spread. The multivariate Cox proportional hazard model resulted in a model that included solid-versus-cystic lymph nodes, T-stage, and radiologic evidence of extracapsular spread as independent predictors of treatment failure. Patients with cystic nodal metastasis at staging had significantly better disease-free survival than patients with solid lymph nodes. CONCLUSIONS: In human papilloma virus–related oropharyngeal squamous cell carcinoma, patients with solid lymph node metastases are at higher risk for treatment failure with worse disease-free survival. Solid lymph nodes may serve as an imaging biomarker to tailor individual treatment regimens.
Berberis vulgaris: specifications and traditional uses

The medicinal plants from genus Berberis are particularly important in traditional medicine and the food basket of Iranians. Given various plants from genus Berberis and their economic, nutritional, and medicinal status in Iran, this study seeks to investigate the findings of recent studies on the phytochemical characteristics, specifications, and uses of Berberis vulgaris. In this review article, 350 articles were initially retrieved from reliable scientific databases using relevant search terms. Then, 230 articles were selected and 120 were excluded after a primary analysis. Finally, 98 articles related to the subject under study were meticulously examined and the required data were extracted and classified according to the research purposes. The findings were divided into eight separate sections: Introducing Berberidaceae family, different species of Berberis, pharmaceutical organs, B. vulgaris nutrition facts and minerals, the antioxidants and alkaloids compounds in fruit and other organs, action mechanisms of preventing and treating diseases, traditional uses of B. vulgaris, and its properties reported by recent studies. The results briefly indicate that B. vulgaris contains a large number of phytochemical materials including ascorbic acid, vitamin K, several triterpenoids, more than 10 phenolic compounds and more than 30 alkaloids. Therefore B. vulgaris may have anti-cancer, anti-inflammatory, antioxidant, antidiabetic, antibacterial, analgesic and anti-nociceptive and hepato-protective effects. Regarding the use of different organs of B. vulgaris in traditional medicine and their confirmed effects in the recent studies, it is possible to use different organs of B. vulgaris, especially fruit, to develop new drugs.
Risk of Asthmatic Episodes in Children Exposed to Sulfur Dioxide Stack Emissions from a Refinery Point Source in Montreal, Canada

Background Little is known about the respiratory effects of short-term exposures to petroleum refinery emissions in young children. This study is an extension of an ecologic study that found an increased rate of hospitalizations for respiratory conditions among children living near petroleum refineries in Montreal (Canada). Methods We used a time-stratified case–crossover design to assess the risk of asthma episodes in relation to short-term variations in sulfur dioxide levels among children 2–4 years of age living within 0.5–7.5 km of the refinery stacks. Health data used to measure asthma episodes included emergency department (ED) visits and hospital admissions from 1996 to 2004. We estimated daily levels of SO2 at the residence of children using a) two fixed-site SO2 monitors located near the refineries and b) the AERMOD (American Meteorological Society/Environmental Protection Agency Regulatory Model) atmospheric dispersion model. We used conditional logistic regression to estimate odds ratios associated with an increase in the interquartile range of daily SO2 mean and peak exposures (31.2 ppb for AERMOD peaks). We adjusted for temperature, relative humidity, and regional/urban background air pollutant levels. Results The risks of asthma ED visits and hospitalizations were more pronounced for same-day (lag 0) SO2 peak levels than for mean levels on the same day, or for other lags: the adjusted odds ratios estimated for same-day SO2 peak levels from AERMOD were 1.10 [95% confidence interval (CI), 1.00–1.22] and 1.42 (95% CI, 1.10–1.82), over the interquartile range, for ED visits and hospital admissions, respectively. Conclusions Short-term episodes of increased SO2 exposures from refinery stack emissions were associated with a higher number of asthma episodes in nearby children.
Are there sensitive periods when child maltreatment substantially elevates suicide risk? Results from a nationally representative sample of adolescents

Although child maltreatment is a well documented risk factor for suicidal behavior, little is known about whether the timing of child maltreatment differentially associates with risk of suicidal ideation, suicide plans, or suicide attempts. The goal of this study was to examine whether a first exposure to physical or sexual abuse during specific developmental periods significantly elevated risk for suicidal behavior in adolescents.
Management of small-cell lung cancer: time to move forward.

Small-cell lung cancer (SCLC) is a pathologically distinct malignancy of the lung, characterized by rapid growth, propensity for early metastatic spread, and responsiveness to chemotherapy and radiation. Despite its generally good initial response, the relapse and subsequent mortality rate remain very high. Only 3% to 8% of all patients survive 5 years, and median survival for extensive stage disease is 8 to 13 months. [1,2]
Features that define the best ChIP-seq peak calling algorithms

Abstract Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is an important tool for studying gene regulatory proteins, such as transcription factors and histones. Peak calling is one of the first steps in the analysis of these data. Peak calling consists of two sub-problems: identifying candidate peaks and testing candidate peaks for statistical significance. We surveyed 30 methods and identified 12 features of the two sub-problems that distinguish methods from each other. We picked six methods GEM, MACS2, MUSIC, BCP, Threshold-based method (TM) and ZINBA] that span this feature space and used a combination of 300 simulated ChIP-seq data sets, 3 real data sets and mathematical analyses to identify features of methods that allow some to perform better than the others. We prove that methods that explicitly combine the signals from ChIP and input samples are less powerful than methods that do not. Methods that use windows of different sizes are more powerful than the ones that do not. For statistical testing of candidate peaks, methods that use a Poisson test to rank their candidate peaks are more powerful than those that use a Binomial test. BCP and MACS2 have the best operating characteristics on simulated transcription factor binding data. GEM has the highest fraction of the top 500 peaks containing the binding motif of the immunoprecipitated factor, with 50% of its peaks within 10 base pairs of a motif. BCP and MUSIC perform best on histone data. These findings provide guidance and rationale for selecting the best peak caller for a given application.
Ex po re

Recent research in social psychology has examined how psychological power affects organizational behaviors. Given that power in organizations is generally viewed as a structural construct, I examine the links between structural and psychological power and explore how their interrelationships affect organizational behavior. I argue that psychological power takes two forms: the (nonconscious) cognitive network for power and the conscious sense of power. Based on this view, I identify two causal pathways that link psychological power and structural power in predicting organizational behavior. First, the sense of power is likely to induce a sense of responsibility among (but not exclusively among) structural powerholders, which in turn leads structural powerholders to be more responsive to the views and needs of others. Second, the sense of power, when brought into conscious awareness, activates a non-conscious association between power and agentic behaviors, which in turn leads structural powerholders to enact agentic behaviors. I discuss the ways in which these predictions diverge from previous theorizing, and I address methodological challenges in examining the relationship between structural and psychological power. In doing so, I suggest that certain features of the predominant methodological approaches to studying psychological power may have induced a bias in the empirical findings that obscures the crucial link between power and responsibility. 2015 Elsevier Ltd. All rights reserved. Tel. : +1 919 210 7581. E-mail address: lptost@umich.edu
Post-conflict slowing effects in monolingual and bilingual children.

Previous research has shown that bilingual children outperform their monolingual peers on a wide variety of tasks measuring executive functions (EF). However, recent failures to replicate this finding have cast doubt on the idea that the bilingual experience leads to domain-general cognitive benefits. The present study explored the role of disengagement of attention as an explanation for why some studies fail to produce this result. Eighty children (40 monolingual, 40 bilingual) who were 7 years old performed a task-switching experiment. In the pure blocks, three simple non-conflict tasks were performed in which children responded by pressing one of two response keys. In the conflict block, occasional bivalent stimuli appeared and created conflict because the irrelevant dimension was mapped to the incorrect response key. The results showed that these bivalent stimuli affected subsequent performance in the conflict block. For monolinguals, the effect of conflict was found for up to 12 trials after the appearance of the bivalent stimulus, but for bilinguals the effect disappeared after only two trials. The results are interpreted as evidence for faster disengagement of attention by bilingual children. Most studies examining EF in monolingual and bilingual children do not examine trial-by-trial adjustments following conflict, but these are essential considerations because relevant processing differences are masked when analyses are applied to data averaged across entire blocks.
Sequence Variations in 185/333 Messages from the Purple Sea Urchin Suggest Posttranscriptional Modifications to Increase Immune Diversity1

The 185/333 gene family is highly expressed in two subsets of immune cells in the purple sea urchin in response to immune challenges. The genes encode a surprisingly diverse set of transcripts, which is a function of the variable presence or absence of blocks of shared sequences, known as elements that generate element patterns. Diversity is also the result of a significant level of point mutations. Together, variable element patterns and single nucleotide polymorphisms result in many unique transcripts. The 185/333 genes only have two exons, with the variable element patterns encoded entirely within the second exon. The diversity of the gene family may be the result of frequent recombination among the 185/333 genes that generates a mosaic distribution of element sequences among the genes. A comparative analysis of the sequences for the genes and messages from individual sea urchins indicates that these two sequence sets have largely different nucleotide sequences and appear to use different element patterns. Furthermore, the nucleotide substitution patterns between genes and messages reveal a strong bias toward transitions, particularly cytidine to uridine conversions. These data are consistent with cytidine deaminase activity and may represent a novel form of immunological diversification in an invertebrate immune response system.
Deep structured features for semantic segmentation

We propose a highly structured neural network architecture for semantic segmentation with an extremely small model size, suitable for low-power embedded and mobile platforms. Specifically, our architecture combines i) a Haar wavelet-based tree-like convolutional neural network (CNN), ii) a random layer realizing a radial basis function kernel approximation, and iii) a linear classifier. While stages i) and ii) are completely pre-specified, only the linear classifier is learned from data. We apply the proposed architecture to outdoor scene and aerial image semantic segmentation and show that the accuracy of our architecture is competitive with conventional pixel classification CNNs. Furthermore, we demonstrate that the proposed architecture is data efficient in the sense of matching the accuracy of pixel classification CNNs when trained on a much smaller data set.
Investigating the relationship between interoceptive accuracy, interoceptive awareness, and emotional susceptibility

Interoception, the sense of the physiological condition of the body, provides a basis for subjective feelings and emotions. Anterior insular cortex activity represents the state of the body and varies according to personality traits, such as emotional susceptibility (ES)—the tendency to experience feelings of discomfort and vulnerability when facing emotionally-laden stimuli. The accuracy of perceiving one's own bodily signals, or interoceptive accuracy (IAc), can be assessed with the heartbeat perception task (HPT), which is the experimental measure used by most of the existing research on interoception. However, IAc is only one facet of interoception. Interoceptive awareness (IAw) is the conscious perception of sensations from inside the body, such as heart beat, respiration, satiety, and the autonomic nervous system sensations related to emotions, which create the sense of the physiological condition of the body. We developed an Italian version of the recent self-report Multidimensional Assessment of Interoceptive Awareness (MAIA), tested its psychometric properties (reliability, dimensionality, and construct validity), and examined its relationship to ES, as assessed using the Emotional Susceptibility Scale, in a sample (n = 321) of healthy Italian psychology students (293 females, mean age: 20.5 years). In a subgroup of females (n = 135), we measured IAc with the HPT. We used a series of correlation/regression analyses to examine the complex interplay between the three constructs. We provide further evidence for a substantial independence of the IAc and IAw measures, confirming previous reports and current theoretical models that differentiate between IAc and IAw. Our analyses elucidate the complex relationship between distinct dimensions of IAw and ES, highlighting the need for continued efforts to shed more light on this topic.
Effect of circadian rhythm on peak expiratory flow rate in healthy young adults

Background: Many human biological systems, including airway calibre, show a circadian rhythm. This may be because the airways are passively influenced by the rhythm of related endogenous systems or because they respond directly to cyclically varying exogenous stimuli. The peak expiratory flow rate (PEFR) is an accepted marker of pulmonary function, primarily reflects large airway flow and depends on the voluntary effort and muscular strength of the patient. Aims and Objective: In the present study an attempt has been made to investigate the effect of circadian rhythm on peak expiratory flow rate in healthy young adults.Method : Peak expiratory flow rate (PEFR) was observed at 5:00 am, 8:00 am, 11:00 am, 2:00 pm, 5:00 pm, 8:00 pm, and 11:00 pm on two consecutive days. The highest value of PEFR from at least three acceptable blows was recorded separately and used for the analysis. Only PEFR readings recorded at 11 pm on first day and all readings on the second day were taken into consideration to rule out the remote possibility of training effect. The Diurnal Variation in PEFR is calculated as the difference between the highest and the lowest PEFR values as a percentage of the mean PEFR on each day. Result: The lowest mean PEFR and mean (%) PEFR value was recorded at 5 am (487.8 L/min) and highest at 5 pm (527.4 L/min) for the study group. The mean PEFR values at different time points were analysed for variation using ANOVA which did not reveal significant rhythm (P>0.5). After normalizing the data, the circadian rhythm of PEFR was statistically significant (P<0.001). The data was also analyzed by comparing mean PEFR values at different time points using repeated measures ANOVA test with Bonferroni’s test which showed that there is significant difference between the mean PEFR values at 11pm on day one and mean PEFR values at 5am, 11am, 2pm, 5pm & 8pm on second day (P value < 0.05). Conclusion: Our study suggests that there is a significant variation in peak expiratory flow rate between morning and evening in healthy young adult population. This is important in understanding the behaviour of airways in producing changes in PEFR. We conclude that a diurnal variation pattern of PEFR exists in healthy population. This knowledge is important for any meaningful interpretation of PEFR recordings used to screen population for asthma.
Phylogeography of Quercus variabilis Based on Chloroplast DNA Sequence in East Asia: Multiple Glacial Refugia and Mainland-Migrated Island Populations

The biogeographical relationships between far-separated populations, in particular, those in the mainland and islands, remain unclear for widespread species in eastern Asia where the current distribution of plants was greatly influenced by the Quaternary climate. Deciduous Oriental oak (Quercus variabilis) is one of the most widely distributed species in eastern Asia. In this study, leaf material of 528 Q. variabilis trees from 50 populations across the whole distribution (Mainland China, Korea Peninsular as well as Japan, Zhoushan and Taiwan Islands) was collected, and three cpDNA intergenic spacer fragments were sequenced using universal primers. A total of 26 haplotypes were detected, and it showed a weak phylogeographical structure in eastern Asia populations at species level, however, in the central-eastern region of Mainland China, the populations had more haplotypes than those in other regions, with a significant phylogeographical structure (N ST = 0.751> G ST = 0.690, P<0.05). Q. variabilis displayed high interpopulation and low intrapopulation genetic diversity across the distribution range. Both unimodal mismatch distribution and significant negative Fu’s FS indicated a demographic expansion of Q. variabilis populations in East Asia. A fossil calibrated phylogenetic tree showed a rapid speciation during Pleistocene, with a population augment occurred in Middle Pleistocene. Both diversity patterns and ecological niche modelling indicated there could be multiple glacial refugia and possible bottleneck or founder effects occurred in the southern Japan. We dated major spatial expansion of Q. variabilis population in eastern Asia to the last glacial cycle(s), a period with sea-level fluctuations and land bridges in East China Sea as possible dispersal corridors. This study showed that geographical heterogeneity combined with climate and sea-level changes have shaped the genetic structure of this wide-ranging tree species in East Asia.
University of Birmingham The role of self-determined motivation to the understanding of exercise-related behaviours, cognitions and physical self-evaluations

Grounded in Self-Determination Theory (Deci and Ryan, 1985), the purpose of the present study was to examine whether amotivation, self-determined, and controlling types of motivation could predict a range of exercise-related behaviours, cognitions and physical self-evaluations. Exercisers ( N = 375) from ten health clubs in the North of England completed questionnaires measuring exercise motivation, exercise stages of change, number of relapses from exercise, future intention to exercise, barriers self-efficacy, physical self-worth and social physique anxiety. Controlling for age and gender, multiple and logistic regression analyses supported our hypotheses by showing self-determined motivation (i.e. intrinsic motivation and identified regulation) to predict more adaptive behavioural, cognitive and physical self-evaluation patterns compared to external regulation and amotivation. Introjected regulation was related to both adaptive and maladaptive outcomes. Furthermore, a MANOVA test revealed that exercisers in the maintenance stage of change displayed significantly more self-determined motivation to exercise compared to those in the preparation and action stages. In sum, the results illustrate the importance of promoting self-determined motivation in exercisers in order to improve the quality of their experiences as well as to foster their exercise behaviour. Future research should examine the mechanisms that promote self-determined motivation in exercise.