Miracle-dz/UniFAR-FTUs huggingface dataset:
Tau impacts on growth-factor-stimulated actin remodeling

The microtubule-associated protein tau interacts with the SH3 domain of non-receptor Src family protein tyrosine kinases. A potential consequence of the SH3 interaction is the upregulation of tyrosine kinase activity. Here we investigated the activation of Src or Fyn by tau, both in vitro and in vivo. Tau increased the kinase activity in in vitro assays and in transfected COS7 cells. In platelet-derived growth factor (PDGF)-stimulated fibroblasts, tau appeared to prime Src for activation following PDGF stimulation, as reflected by changes in Src-mediated actin rearrangements. In addition, while fibroblasts normally recovered actin stress fibers by 5-7 hours after PDGF stimulation, tau-expressing cells showed sustained actin breakdown. Microtubule association by tau was not required for the observed changes in actin morphology. Inhibition of Src kinases or a mutant deficient in Src interaction reduced the effects, implicating Src family protein tyrosine kinases as a mediator of the effects of tau on actin rearrangements. Our results provide evidence that the interaction of tau with Src upregulates tyrosine kinase activity and that this interaction allows tau to impact on growth-factor-induced actin remodeling.
Media violence effects and violent crime: Good science or moral panic?

Whether exposure of children or adults to violent media is a cause of aggression and violent behavior has been one of the most intensely debated issues in criminal justice and the broader populace. Debates about the effects of media ranging from books to video games have a long history (Trend, 2007). Even religious writings such as the Bible have been the target of criticism, from early Christian writings in the Roman Empire to “native” language translations of the Bible in the late medieval period. In fact, the Bible recently came back in the spotlight with a study suggesting that reading passages from the Bible with violent content provokes aggression in the same manner as violent video games or television allegedly do (Bushman, Ridge, Das, Key & Busath, 2007). The 20th century has seen many other examples, from Harry Potter teaching witchcraft, to the concern (largely evaporated) that playing Dungeons and Dragons would lead to Satanism or mental illness, to the Hays Code “taming” of Betty Boop (which, by forcing her to put on more clothes, doomed the comic strip). Concerns have come and gone that media such as comic books, jazz, rock, rap, role-playing games, and books, as well as television and movies, would lead to waves of rebelliousness, violence, and moral degradation. New media such as video games and the Internet inevitably
Measuring mild cognitive impairment in patients with Parkinson's disease

We examined the frequency of Parkinson disease with mild cognitive impairment (PD‐MCI) and its subtypes and the accuracy of 3 cognitive scales for detecting PD‐MCI using the new criteria for PD‐MCI proposed by the Movement Disorders Society. Nondemented patients with Parkinson's disease completed a clinical visit with the 3 screening tests followed 1 to 3 weeks later by neuropsychological testing. Of 139 patients, 46 met Level 2 Task Force criteria for PD‐MCI when impaired performance was based on comparisons with normative scores. Forty‐two patients (93%) had multi‐domain MCI. At the lowest cutoff levels that provided at least 80% sensitivity, specificity was 44% for the Montreal Cognitive Assessment and 33% for the Scales for Outcomes in Parkinson's Disease‐Cognition. The Mini‐Mental State Examination could not achieve 80% sensitivity at any cutoff score. At the highest cutoff levels that provided specificity of at least 80%, sensitivities were low (≤44%) for all tests. When decline from estimated premorbid levels was considered evidence of cognitive impairment, 110 of 139 patients were classified with PD‐MCI, and 103 (94%) had multi‐domain MCI. We observed dramatic differences in the proportion of patients who had PD‐MCI using the new Level 2 criteria, depending on whether or not decline from premorbid level of intellectual function was considered. Recommendations for methods of operationalizing decline from premorbid levels constitute an unmet need. Among the 3 screening tests examined, none of the instruments provided good combined sensitivity and specificity for PD‐MCI. Other tests recommended by the Task Force Level 1 criteria may represent better choices, and these should be the subject of future research. © 2013 Movement Disorder Society
Secrecy Performance of Finite-Sized Cooperative Single Carrier Systems With Unreliable Backhaul Connections

In this paper, the secrecy performance of finite-sized cooperative cyclic prefixed single carrier systems with multiple eavesdroppers and unreliable wireless backhaul connections across multiple transmitters is investigated. For nonidentical frequency-selective fading channels between the relay and destination nodes, secrecy performance metrics including the secrecy outage probability, ergodic secrecy rate, and probability of nonzero achievable secrecy rate are derived. Furthermore, the existence of performance limits on the secrecy outage probability and probability of non-zero achievable secrecy rate are verified for various backhaul scenarios. These limits are found to be exclusively determined by the backhaul reliability. For imperfect backhaul connections, it is found that the diversity gain promised by cooperative cyclic prefixed single-carrier systems cannot be achieved in the conventional asymptotic high signal-to-noise ratio region. Link-level simulations are conducted to verify the derived impact of backhaul reliability on the secrecy performance.
An Effective Web Service Ranking Method via Exploring User Behavior

Service-oriented computing and Web services are becoming more and more popular, enabling organizations to use the Web as a market for selling their own Web services and consuming existing Web services from others. Nevertheless, with the increasing adoption and presence of Web services, it becomes more difficult to find the most appropriate Web service that satisfies both users' functional and nonfunctional requirements. In this paper, we propose an effective Web service ranking approach based on collaborative filtering (CF) by exploring the user behavior, in which the invocation and query history are used to infer the potential user behavior. CF-based user similarity is calculated through similar invocations and similar queries (including functional query and QoS query) between users. Three aspects of Web services-functional relevance, CF based score, and QoS utility, are all considered for the final Web service ranking. To avoid the impact of different units, range, and distribution of variables, three ranks are calculated for the three factors respectively. The final Web service ranking is obtained by using a rank aggregation method based on rank positions. We also propose effective evaluation metrics to evaluate our approach. Large-scale experiments are conducted based on a real world Web service dataset. Experimental results show that the proposed approach outperforms the existing approach on the rank performance.
Low-complexity near-optimal signal detection for uplink large-scale MIMO systems

The minimum mean square error (MMSE) signal detection algorithm is near-optimal for uplink multi-user large-scale multiple-input-multiple-output (MIMO) systems, but involves matrix inversion with high complexity. It is firstly proved that the MMSE filtering matrix for large-scale MIMO is symmetric positive definite, based on which a low-complexity near-optimal signal detection algorithm by exploiting the Richardson method to avoid the matrix inversion is proposed. The complexity can be reduced from O(K 3 ) to O(K 2 ), where K is the number of users. The convergence proof of the proposed algorithm is also provided. Simulation results show that the proposed signal detection algorithm converges fast, and achieves the near-optimal performance of the classical MMSE algorithm.
An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture

Cerebellar long-term depression (LTD) is a model system of information storage in which a persistent attenuation of the parallel fiber- Purkinje neuron (PN) synapse is induced by conjunctive stimulation of parallel fiber and climbing fiber inputs at low frequency. As some studies have suggested that release of the gaseous second messenger, nitric oxide (NO), in the molecular layer and the consequent activation of soluble guanylate cyclase and cGMP-dependent protein kinase (PKG) in the PN, is necessary for LTD induction, we have further examined this hypothesis using a cell culture protocol. In cerebellar cultures made from transgenic mice in which the gene for neuronal nitric oxide synthase (nNOS) has been rendered null, LTD induced by glutamate/depolarization conjunctive stimulation was indistinguishable from that in cultures from wild-type mice in terms of amplitude, rate of onset, and duration. Bath application of cGMP analogs produced a large (80%), transient attenuation of glutamate-gated inward currents. However, application of an activator of soluble guanylate cyclase or an inhibitor of type V cGMP-phosphodiesterase did not mimic the effect of cGMP analogs, and inclusion of cGMP analogs in the patch pipette did not give rise to a slowly developing attenuation, suggesting that these compounds exert their effects at the cell surface. Free Ca was measured in the distal dendritic arbor of single PNs by fura-2 microfluorimetry.
Link Investigation of IEEE 802.15.4 Wireless Sensor Networks in Forests

Wireless sensor networks are expected to automatically monitor the ecological evolution and wildlife habits in forests. Low-power links (transceivers) are often adopted in wireless sensor network applications, in order to save the precious sensor energy and then achieve long-term, unattended monitoring. Recent research has presented some performance characteristics of such low-power wireless links under laboratory or outdoor scenarios with less obstacles, and they have found that low-power wireless links are unreliable and prone to be affected by the target environment. However, there is still less understanding about how well the low-power wireless link performs in real-world forests and to what extent the complex in-forest surrounding environments affect the link performances. In this paper, we empirically evaluate the low-power links of wireless sensors in three typical different forest environments. Our experiment investigates the performance of the link layer compatible with the IEEE 802.15. 4 standard and analyzes the variation patterns of the packet reception ratio (PRR), the received signal strength indicator (RSSI) and the link quality indicator (LQI) under diverse experimental settings. Some observations of this study are inconsistent with or even contradict prior results that are achieved in open fields or relatively clean environments and thus, provide new insights both into effectively evaluating the low-power wireless links and into efficiently deploying wireless sensor network systems in forest environments.
Saccade-related activity in the lateral intraparietal area. II. Spatial properties.

1. Single-neuron activity was recorded from the inferior parietal lobule (IPL) of Macaca mulatta monkeys while they were performing delayed saccades and related tasks. Temporal characteristics of this activity were presented in the companion paper. Here we focus on the spatial characteristics of the activity. The analysis was based on recordings from 145 neurons. All these neurons were from the lateral intraparietal area (LIP), a recently defined subdivision of the IPL. 2. Delayed saccades were made in eight directions. Direction-tuning curves were calculated for each neuron, during each of the following activity phases that were described in the companion paper: light sensitive (LS), delay-period memory (M), and saccade related (S); the latter further partitioned into presaccadic (Pre-S), saccade coincident (S-Co), and postsaccadic (Post-S). 3. Width and preferred direction were calculated for each direction-tuning curve. We studied the distributions of widths and preferred directions in LIP's neuronal population. In each case we included only neurons that showed clear excitatory activity in the phases in question. 4. Width was defined as the angle over which the response was higher than 50% of its maximal net value. Width distributions were similar for all phases studied. Widths varied widely from neuron to neuron, from very narrow (less than 45 degrees) to very wide (close to 360 degrees). Median widths were approximately 90 degrees in all phases. 5. Preferred-direction distributions were also similar for various phases. All directions were represented in each distribution, but contralateral directions were more frequent (e.g., 69% for S-Co). 6. For each neuron the alignment of the preferred directions of its various phases was determined. Distributions of alignments were calculated (again, phases that were not clearly excitatory were disregarded). On the level of the neuronal population LS, M, and Pre-S were well aligned with each other. S-Co was also aligned with these phases, but less precisely. 7. A set of "narrowly tuned" neurons was selected by imposing a constraint of narrow (width, less than 90 degrees) LS and S-Co direction tuning. In this set of neurons, the LS and S-Co preferred directions were very well aligned (median, 12 degrees). The fraction of narrowly tuned neurons in the population was 40% (25/63). Thus, in a large subpopulation of area LIP, a fairly precise alignment exists between sensory and motor fields. 8. An additional set of 82 area LIP neurons were recorded while the monkey performed delayed saccades to 32 targets located on small, medium, and large imaginary circles. (ABSTRACT TRUNCATED AT 400 WORDS)
Modulation of mismatch negativity by stimulus deviance and modality of attention

We studied the effect of attention on the processing of auditory sensory inputs by means of the mismatch negativity (MMN) potential, which can be derived from event-related EEG. A series of frequent standard and rare deviant auditory stimuli were presented to 20 healthy subjects in two recording sessions about five weeks apart. Deviant stimuli were either low or highly deviant as compared to the standard stimulus. While MMN was recorded, subjects were performing a visual and, subsequently, an auditory discrimination task. Directing attention towards the auditory task was associated with increased MMN amplitude only in response to low deviant stimuli and only in the first recording session. No change of MMN amplitude was found when directing attention towards the visual task or when MMN was recorded in response to highly deviant auditory stimuli. The latter may trigger an involuntary switch of attention, thereby overwriting the effect of task-directed attention. Conversely, the effects of attention on the processing of low deviant stimuli appear to be fragile and diminish with increasing automaticity of task execution.
Reconciling Consumption Inequality with Income Inequality

The rise in within-group consumption inequality in response to the increase in within-group income inequality over the last three decades in the U.S. is puzzling to expected-utility-based incomplete market models. The two-sided lack of commitment models exhibit too little consumption inequality while the standard incomplete markets models tend to predict too much consumption inequality. We show that a model with two-sided lack of commitment and chance attitudes, as emphasized by prospect theory, can explain the relationship and can avoid the systematic bias of the expected utility models. The chance attitudes, such as optimism and pessimism, imply that the households attribute a higher weight to high and low outcomes compared to their objective probabilities. For realistic values of risk aversion and of chance attitudes, the incentives for households to share the idiosyncratic risk decrease. The latter effect endogenously amplifies the increase in consumption inequality relative to the expected utility model, thereby improving the fit to the data.
Newton polygons of zeta functions and L functions

In this article we give a systematic treatment of Newton polygons of exponential sums. The Newton polygon is a nice way to describe p-adic values of the zeroes or poles of zeta functions and L functions. Our main objective is to show that the Adolphson-Sperber conjecture 12], which asserts that under a simple condition the generic Newton polygon of L functions coincides with its lower bound, is false in its full form, but true in a slightly weaker form. We also show that the full form is true in various important special cases. For example, we show that for a generic projective hypersurface of degree d, the Newton polygon of the interesting part of the zeta function coincides with its lower bound (the Hodge polygon). This gives a p-adic proof of a recent theorem of Illusie, conjectured by Dwork and Mazur. For more examples, let us consider the family of affine hypersurfaces of degree d or the family of affine hypersurfaces defined by polynomials f(xi, . . ., x7n) of degree di with respect to xi (1 < i < n), where the di are fixed positive integers. Then, for all large prime numbers p, the generic Newton polygon for the zeta functions of each of the two families of hypersurfaces coincides with its lower bound. We obtain our main results, namely several decomposition theorems, using certain maximizing functions from linear programming. Our work suggests a possible connection between Newton polygons and the resolution of singularities of toric varieties. Let p be a prime, q = pa, and let Fq be the finite field of q elements and Fqm its extension of degree m. Fix a nontrivial additive character qP of Fp. For any Laurent polynomial f(xi, . . ., xn) E Fq[xl, xj1,. , x, xi1] we form
Applicability of Levenson LoC Scale to the Lives of Geriatric Nursing Home Residents

Locus of control (LOC) has been studied as a parameter for personality assessment since its development in 1966. Several studies of the correlation of LOC with such theological components as faith and spirituality have been reported with varying conclusions regarding the relationship of these concepts. However, the question of how theological issues are assessed within the Levenson LOC scale and assessment of the applicability of this instrument to the lives of older adults, as interpreted by members of this population, has not been addressed. This study investigates those two aspects of the Levenson LOC scale and offers suggestions of how these preliminary findings might be applied in counseling this population.
CO-EXISTENCE OF PHYSICAL ACTIVITY (PA) AND OTHER ENERGY-BALANCE RELATED BEHAVIOURS AMONG ADOLESCENTS PARTICIPATING IN PA INTERVENTION IN POLAND

The aim of this study was to identify clusters based on four energy – balance related behaviours (EBRBs) – moderatevigorous physical activity, screen time, breakfast consumption and sweet drinks consumption – among adolescents participating in a governmental programme to increase their sport participation. The study was a part of the monitoring and evaluation process of a nationwide sport intervention in Poland. The sample consisted of 367 participants (180 females and 187 males, mean age 15.18 ±1.67). Data was self-reported. Based on combination of cluster analysis, a five-cluster solution was found the most suitable. Some patterns of EBRBs were similar to the results obtained in previous studies conducted on the general population on, for example “sedentarysnacking” or “all-round-healthy” clusters. The amount of the clusters which accumulated most of the negative or positive behaviours were small, and most clusters presented a mix of behavioural patterns influencing energy balance in both positive and negative ways. The structure of the clusters differed based on adolescents’ gender and, for male participants, fathers’ education (p < 0.05).
Ortaokul Öğrencilerinin Üstbiliş Farkındalıklarının ve Bilimin Doğasına Yönelik Görüşlerinin Cinsiyet ve Akademik Başarılarına Göre İncelenmesi

Bu calismanin amaci ortaokul ogrencilerinin ustbilis farkindaliklarinin ve bilimin dogasina yonelik goruslerinin, cinsiyet ve akademik basari degiskenlerine gore incelenmek olarak belirlenmistir. Nicel arastirma yaklasimi olarak kesitsel tarama modeli kullanilmistir. Bu calismada ogrencilerin ustbilis ve bilimin dogasi goruslerini belirlemek icin iki olcek kullanilmistir. Bu olcekler Ustbilis Farkindalik Olcegi (Junior Metacognitive Awareness Inventory) ve Bilimin Dogasi Gorusler Olcegidir (Nature Of Science Instrument). Veriler, Aydin ili Merkez ilcedeki tabakali amacsal ornekleme yontemiyle secilen bes ortaokuldaki 5. 6. 7. ve 8. siniflarda ogrenim goren 641 ogrenciden toplanmistir. Ogrencilerin ustbilis ve bilimin dogasi goruslerinin cinsiyet ve akademik basarilarina gore degisimi coklu varyans analizi ile (MANOVA) ile test edilmistir. Ayrica, ogrencilerin akademik basarilarina gore farkliligin hangi seviyeler arasinda oldugunu bulmak icin Tukey HSD testi kullanilmistir. Sonuclar, ogrencilerin ustbilis ve bilimin dogasi goruslerinin akademik basarilarina gore farklilik gosterdigini ancak cinsiyet degiskenine gore ogrencilerin ustbilis ve bilimin dogasi gorusleri arasinda anlamli bir fark olmadigini gostermistir. Calisma sonuclari fen egitimcilerinin, ogretmenlerin ve ogretmen adaylarinin ogrencilerinin ustbilis farkindaliklari ve bilimin dogasi gorusleri hakkinda bilgi sahibi olmalari ve anlamalari icin destek saglayabilmektedir. Ogrencilerin basari duzeylerine gore farklilasan bilimin dogasi gorusleri ve ustbilis farkindaliklari dikkate alinarak ogrenme ortamlari yeniden duzenlenebilir ve farkli basari duzeyine sahip ogrencilerin bireysel farkliliklarina gore etkinlikler tasarlanabilir.
Deriving Hidden Junction in Solid Model Reconstruction Using Neural Network

Research on solid model reconstruction has been started since 1970s and it is still investigated since then. In other fields of research, it also takes important role such as in fields as diverse as product design, engineering and rapid prototyping, medical imaging and artistic applications. Furthermore, it has turned out to be essential needs. This paper presents a new algorithm in reconstructing solid model using neural network with back propagation that has been successfully used by few researchers in deriving depth values of visible junction. The algorithm presented in this paper extends the previous works by Matondang et al. in 2007, which is reconstruct solid model from twodimensional (2D) line drawing by deriving depth values. And now in this paper the reconstruction of solid model is continued by deriving the hidden junction and produces complete solid model. Affine transformation in form of rotation is employed to generate the coordinate values that are required in the development of the proposed algorithm. Besides the algorithm, this paper also presents a new framework in solid model reconstruction using neural network. Comparison among three algorithms of previous works in terms of the accuracy and the ease of the algorithm are presented. The experimental results of three 2D line drawings, cube, Lblock and stair, show that the proposed algorithm is capable in deriving hidden junction for solid model reconstruction and can be used as a new alternative in reconstructing solid model.