Miracle-dz/UniFAR-FTUs huggingface dataset:
Neonatal Herpes Simplex Infection

SUMMARY Tremendous advances have occurred over the past 30 years in the diagnosis and management of neonatal herpes simplex virus (HSV) disease. Mortality in patients with disseminated disease has decreased from 85 to 29%, and that in patients with central nervous system (CNS) disease has decreased from 50 to 4%. Morbidity has been improved more modestly: the proportion of patients with disseminated disease who are developing normally at 1 year has increased from 50 to 83%. While the proportion of patients with neurologic morbidity following CNS disease has remained essentially unchanged over the past three decades, the total number of patients who are developing normally following HSV CNS disease has increased due to the improved survival. Although additional therapeutic advances in the future are possible, more immediate methods for further improvements in outcome for patients with this potentially devastating disease lie in an enhanced awareness of neonatal HSV infection and disease. A thorough understanding of the biology and natural history of HSV in the gravid woman and the neonate provides the basis for such an index of suspicion and is provided in this article.
Breast enlargement in Malawian males on the standard first-line antiretroviral therapy regimen: Case reports and review of the literature.

Case presentations 1. A 35-year-old man was referred to Zomba Central Hospital in June 2014 from a health center with a presenting complaint of enlarged breasts. This had started gradually, approximately six months prior. He did not experience any pain or discharge from his nipples. He had no other complaints and felt generally healthy. In early 2013 he had been concomitantly diagnosed with pulmonary tuberculosis and HIV infection and was started on cotrimoxazole prophylaxis and antiretroviral therapy (ART) with tenofovir, lamivudine, and efavirenz, which is the standard first-line adult ART regimen, known in Malawi as regimen 5A. At that point, he had WHO clinical stage III HIV disease; a CD4 count was not done. There was no further relevant past medical history. He looked healthy and had normal vital signs. The rest of the physical examination was normal except for bilateral, symmetrical, elastic, and concentric swelling of the breasts, without discrete nodules, skin changes, or lymphadenopathy in the axillae and neck. There were no features of lipodystrophy and no stigmata of chronic liver disease. The genital examination was normal, without palpable abnormalities of the normal-sized testes. Upon laboratory investigation, his CD4 count was 130 cells/μL and a full blood count was normal apart from the presence of macrocytosis. Liver enzymes were unremarkable.
Soil animal responses to moisture availability are largely scale, not ecosystem dependent: insight from a cross‐site study

Climate change will result in reduced soil water availability in much of the world either due to changes in precipitation or increased temperature and evapotranspiration. How communities of mites and nematodes may respond to changes in moisture availability is not well known, yet these organisms play important roles in decomposition and nutrient cycling processes. We determined how communities of these organisms respond to changes in moisture availability and whether common patterns occur along fine‐scale gradients of soil moisture within four individual ecosystem types (mesic, xeric and arid grasslands and a polar desert) located in the western United States and Antarctica, as well as across a cross‐ecosystem moisture gradient (CEMG) of all four ecosystems considered together. An elevation transect of three sampling plots was monitored within each ecosystem and soil samples were collected from these plots and from existing experimental precipitation manipulations within each ecosystem once in fall of 2009 and three times each in 2010 and 2011. Mites and nematodes were sorted to trophic groups and analyzed to determine community responses to changes in soil moisture availability. We found that while both mites and nematodes increased with available soil moisture across the CEMG, within individual ecosystems, increases in soil moisture resulted in decreases to nematode communities at all but the arid grassland ecosystem; mites showed no responses at any ecosystem. In addition, we found changes in proportional abundances of mite and nematode trophic groups as soil moisture increased within individual ecosystems, which may result in shifts within soil food webs with important consequences for ecosystem functioning. We suggest that communities of soil animals at local scales may respond predictably to changes in moisture availability regardless of ecosystem type but that additional factors, such as climate variability, vegetation composition, and soil properties may influence this relationship over larger scales.
Aripiprazole once-monthly for treatment of schizophrenia: double-blind, randomised, non-inferiority study

Background Long-acting injectable formulations of antipsychotics are treatment alternatives to oral agents. Aims To assess the efficacy of aripiprazole once-monthly compared with oral aripiprazole for maintenance treatment of schizophrenia. Method A 38-week, double-blind, active-controlled, non-inferiority study; randomisation (2:2:1) to aripiprazole once-monthly 400 mg, oral aripiprazole (10–30 mg/day) or aripiprazole once-monthly 50mg (a dose below the therapeutic threshold for assay sensitivity). (Trial registration: clinicaltrials.gov, NCT00706654.) Results A total of 1118 patients were screened, and 662 responders to oral aripiprazole were randomised. Kaplan–Meier estimated impending relapse rates at week 26 were 7.12% for aripiprazole once-monthly 400mg and 7.76% for oral aripiprazole. This difference (−0.64%, 95% CI −5.26 to 3.99) excluded the predefined non-inferiority margin of 11.5%. Treatments were superior to aripiprazole once-monthly 50mg (21.80%, P⩽0.001). Conclusions Aripiprazole once-monthly 400mg was non-inferior to oral aripiprazole, and the reduction in Kaplan–Meier estimated impending relapse rate at week 26 was statistically significant v. aripiprazole once-monthly 50 mg.
Automatic synthesis of burst-mode asynchronous controllers

Asynchronous design has enjoyed a revival of interest recently, as designers seek to eliminate penalties of traditional synchronous design. In principle, asynchronous methods promise to avoid overhead due to clock skew, worst-case design assumptions and resynchronization of asynchronous external inputs. In practice, however, many asynchronous design methods suffer from a number of problems: unsound algorithms (implementations may have hazards), harsh restrictions on the range of designs that can be handled (single-input changes only), incompatibility with existing design styles and inefficiency in the resulting circuits. This thesis presents a new locally-clocked design method for the synthesis of asynchronous controllers. The method has been automated, is proven correct and produces high-performance implementations which are hazard-free at the gate-level. Implementations allow multiple-input changes and handle a relatively unconstrained class of behaviors (called "burst-mode" specifications). The method produces state-machine implementations with a minimal or near-minimal number of states. Implementations can be easily built in such common VLSI design styles as gate-array, standard cell and full-custom. Realizations typically have the latency of their combinational logic. A complete set of state and logic minimization algorithms has been developed and automated for the synthesis method. The logic minimization algorithm differs from existing algorithms since it generates two-level minimized logic which is also hazard-free. The synthesis program is used to produce competitive implementations for several published designs. In addition, a large real-world controller is designed as a case study: an asynchronous second-level cache controller for a new RISC processor.
Chloride transport in partially saturated mortar made of blended cement

Due to environmental (low CO2 emission) and economic benefit, supplementary cementitious materials (SCMs) have been widely used in reinforced concrete structures. However, the question from engineering practice is to which extend these blended mixtures do meet the future durability criteria. Chloride ingression is nowadays considered as the main concern for reinforcement corrosion. Due to self-desiccation or drying process, cement-based materials are no longer saturated, which would greatly influence the chloride transport properties. This paper explores the effect of water saturation level on chloride diffusivity in cement-based materials by resistivity measurements. Experiments were performed on mortars made of different blended materials, i.e. fly ash, blast furnace slag and limestone powder. Mortar materials have been curing for 200 days conditioning in humid room at 20±1°C, followed by oven drying at 50°C until the samples reach targeted water saturation levels. The results showed that chloride diffusivity is highly dependent on the water saturation level and water-vapour desorption isotherm of the mortar material. The dependency varies with cement type, and is significantly related to pore size distribution characteristics. In addition, the effect of water content on chloride diffusivity is more evident in blended cement mortars than reference ordinary Portland cement mortar. For the materials studied in this research, the capillary pores with diameter range of 7.1-73 nm plays dominated role in chloride diffusion under non-saturated state.
Elevated neutrophil to lymphocyte ratio and ischemic stroke risk in generally healthy adults

Elevated neutrophil to lymphocyte ratio (NLR) has been reported as a marker for chronic inflammation, associated with poor prognosis in ischemic stroke patients, but there has been no study that investigated its association with ischemic stroke risk. This study was conducted to investigate elevated NLR as an independent risk factor for ischemic stroke incidence. Our retrospective cohort study included 24,708 generally healthy subjects aged 30–75 who received self-referred health screening at Seoul National University Hospital. Data on ischemic stroke incidence was retrieved from national medical claims registry. Median follow-up time was 5.9 years (interquartile range 4.2 years). Adjusted for major cardiovascular risk factors, compared to subjects with NLR<1.5, subjects with 2.5≤NLR<3.0, 3.0≤NLR<3.5, and NLR≥3.5 had elevated risk for ischemic stroke incidence with aHR (95% CI) of 1.76 (1.09–2.84), 2.21 (1.21–4.04), and 2.96 (1.57–5.58), respectively. NLR showed significant improvement in discrimination for ischemic stroke incidence compared to traditional cardiovascular risk factors (C-index 0.748 vs. 0.739, P = 0.025). There was significant net improvement in reclassification in Framingham risk for ischemic stroke incidence after addition of NLR, with IDI 0.0035 (P<0.0001), and NRI 6.02% (P = 0.0015). This reclassification for ischemic stroke incidence by NLR was markedly pronounced among subjects with atrial fibrillation with CHA2DS2-VASc<2 (NRI 42.41%, P = 0.056). Our study suggests elevated NLR to be an independent risk factor for ischemic stroke incidence in generally healthy adults. Future studies are needed to validate our results and further assess how subjects with elevated NLR should be managed within current guidelines.
OpenFlow MPLS and the open source label switched router

Multiprotocol Label Switching (MPLS) [3] is a protocol widely used in commercial operator networks to forward packets by matching link-specific labels in the packet header to outgoing links rather than through standard IP longest prefix matching. However, in existing networks, MPLS is implemented by full IP routers, since the MPLS control plane protocols such as LDP [8] utilize IP routing to set up the label switched paths, even though the MPLS data plane does not require IP routing. OpenFlow 1.0 is an interface for controlling a routing or switching box by inserting flow specifications into the box's flow table [1]. While OpenFlow 1.0 does not support MPLS1, MPLS label-based forwarding seems conceptually a good match with OpenFlow's flow-based routing paradigm. In this paper we describe the design and implementation of an experimental extension of OpenFlow 1.0 to support MPLS. The extension allows an OpenFlow switch without IP routing capability to forward MPLS on the data plane. We also describe the implementation of a prototype open source MPLS label switched router, based on the NetFPGA hardware platform [4], utilizing OpenFlow MPLS. The prototype is capable of forwarding data plane packets at line speed without IP forwarding, though IP forwarding is still used on the control plane. We provide some performance measurements comparing the prototype to software routers. The measurements indicate that the prototype is an appropriate tool for achieving line speed forwarding in testbeds and other experimental networks where flexibility is a key attribute, as a substitute for software routers.
Bone Demineralization in Postmenopausal Women: Role of Anamnestic Risk Factors

This study evaluated the effects of LT4 administration on the bone mineral density (BMD) in physiological postmenopausal women after two years of continuative treatment. 110 postmenopausal women with nodular goiter aged between 50 and 55 years were examined before and after 2 years of therapy with a fixed dose of LT4 (1.6 mcg/kg/die) for the treatment of nodular thyroid disease. The results showed that the patients on treatment with LT4 have a slight, but significant reduction of the BMD after 2 years of treatment, associated with increased serum levels of alkaline phosphatase and urinary excretion of hydroxyproline, confirming our data conducted on the same group after one year of therapy. Comparison between patients receiving LT4 (group A) or not (group B) showed that group A patients had significantly lower BMD. We demonstrated the statistically significant influence of the following risk factors on BMD: (1) body mass index <19 kg/m(2); (2) the onset of menarche after the age of 15 years; (3) positive history for period of amenorrhoea; (4) nulliparity.
Temperature aware task sequencing and voltage scaling

On-chip power density and temperature are rising exponentially with decreasing feature sizes. This alarming trend calls for temperature management at every level of system design. In this paper, we propose task sequencing as a powerful and complimentary mechanism to voltage scaling in improving the thermal profile of an embedded system executing a set of periodic heterogenous tasks under timing constraints. We first derive the peak temperature of a repeating task sequence analytically and develop a heuristic to construct the task sequence that minimizes the peak temperature. Experimental evaluation shows that our task sequencing heuristic achieves peak temperature within 0.5degC of the optimal solution and 7.47degC lower, on an average, compared to the worst sequence for a large range of embedded task sets. We also propose an iterative algorithm that combines task sequencing with voltage scaling to further lower the peak temperature while satisfying the timing constraints. For embedded task sets, our combined task sequencing and voltage scaling approach achieves, on an average, 2.1degC - 6.94degC reduction in peak temperature compared to voltage scaling alone.
A Latent Variable Recurrent Neural Network for Discourse-Driven Language Models

This paper presents a novel latent variable recurrent neural network architecture for jointly modeling sequences of words and (possibly latent) discourse relations between adjacent sentences. A recurrent neural network generates individual words, thus reaping the benefits of discriminatively-trained vector representations. The discourse relations are represented with a latent variable, which can be predicted or marginalized, depending on the task. The resulting model can therefore employ a training objective that includes not only discourse relation classification, but also word prediction. As a result, it outperforms state-of-the-art alternatives for two tasks: implicit discourse relation classification in the Penn Discourse Treebank, and dialog act classification in the Switchboard corpus. Furthermore, by marginalizing over latent discourse relations at test time, we obtain a discourse informed language model, which improves over a strong LSTM baseline.
Distributed Robust Consensus Using RANSAC and Dynamic Opinions

Sensor networks must be able to fuse nodes' perceptions in a reliable way to reach a trustworthy consensus. Data association mistakes and measurement outliers are some of the factors that can contribute to incorrect perceptions and considerably affect consensus values. In this paper, we present a novel distributed scheme for robust consensus in autonomous sensor networks. The proposed method builds on random sampling consensus to exploit measurement redundancy, and enables the network to determine outlier observations with local communications. To do this, different hypotheses are generated and voted for using distributed averaging. In our approach, nodes can change their opinion as the hypotheses are computed, making the voting process dynamic. Assuming that enough hypotheses are generated to have at least one composed exclusively by inliers, we show that the method converges to the maximum likelihood of all the inlier observations under some natural conditions. We present several simulations and examples with real information that demonstrate the good performance of the proposed algorithm.
Carfilzomib, rituximab, and dexamethasone (CaRD) treatment offers a neuropathy-sparing approach for treating Waldenström's macroglobulinemia.

Bortezomib frequently produces severe treatment-related peripheral neuropathy (PN) in Waldenström's macroglobulinemia (WM). Carfilzomib is a neuropathy-sparing proteasome inhibitor. We examined carfilzomib, rituximab, and dexamethasone (CaRD) in symptomatic WM patients naïve to bortezomib and rituximab. Protocol therapy consisted of intravenous carfilzomib, 20 mg/m2 (cycle 1) and 36 mg/m(2) (cycles 2-6), with intravenous dexamethasone, 20 mg, on days 1, 2, 8, and 9, and rituximab, 375 mg/m(2), on days 2 and 9 every 21 days. Maintenance therapy followed 8 weeks later with intravenous carfilzomib, 36 mg/m(2), and intravenous dexamethasone, 20 mg, on days 1 and 2, and rituximab, 375 mg/m(2), on day 2 every 8 weeks for 8 cycles. Overall response rate was 87.1% (1 complete response, 10 very good partial responses, 10 partial responses, and 6 minimal responses) and was not impacted by MYD88(L265P) or CXCR4(WHIM) mutation status. With a median follow-up of 15.4 months, 20 patients remain progression free. Grade ≥2 toxicities included asymptomatic hyperlipasemia (41.9%), reversible neutropenia (12.9%), and cardiomyopathy in 1 patient (3.2%) with multiple risk factors, and PN in 1 patient (3.2%) which was grade 2. Declines in serum IgA and IgG were common. CaRD offers a neuropathy-sparing approach for proteasome inhibitor-based therapy in WM. This trial is registered at www.clinicaltrials. gov as #NCT01470196.
Comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure.

IMPORTANCE Outcomes associated with use of high-frequency oscillatory ventilation (HFOV) in children with acute respiratory failure have not been established. OBJECTIVE To compare the outcomes of HFOV with those of conventional mechanical ventilation (CMV) in children with acute respiratory failure. DESIGN, SETTING, AND PARTICIPANTS We performed a retrospective, observational study using deidentified data obtained from all consecutive patients receiving mechanical ventilation aged 1 month to 18 years in the Virtual PICU System database from January 1, 2009, through December 31, 2011. The study population was divided into 2 groups: HFOV and CMV. The HFOV group was further divided into early and late HFOV. Propensity score matching was performed as a 1-to-1 match of HFOV and CMV patients. A similar matching process was performed for early HFOV and CMV patients. EXPOSURE High-frequency oscillatory ventilation. MAIN OUTCOMES AND MEASURES Length of mechanical ventilation, intensive care unit (ICU) length of stay, ICU mortality, and standardized mortality ratio (SMR). RESULTS A total of 9177 patients from 98 hospitals qualified for inclusion. Of these, 902 (9.8%) received HFOV, whereas 8275 (90.2%) received CMV. A total of 1764 patients were matched to compare HFOV and CMV, whereas 942 patients were matched to compare early HFOV and CMV. Length of mechanical ventilation (CMV vs HFOV: 14.6 vs 20.3 days, P < .001; CMV vs early HFOV: 14.6 vs 15.9 days, P < .001), ICU length of stay (19.1 vs 24.9 days, P < .001; 19.3 vs 19.5 days, P = .03), and mortality (8.4% vs 17.3%, P < .001; 8.3% vs 18.1%, P < .001) were significantly higher in HFOV and early HFOV patients compared with CMV patients. The SMR in the HFOV group was 2.00 (95% CI, 1.71-2.35) compared with an SMR in the CMV group of 0.85 (95% CI, 0.68-1.07). The SMR in the early HFOV group was 1.62 (95% CI, 1.31-2.01) compared with an SMR in the CMV group of 0.76 (95% CI, 0.62-1.16). CONCLUSIONS AND RELEVANCE Application of HFOV and early HFOV compared with CMV in children with acute respiratory failure is associated with worse outcomes. The results of our study are similar to recently published studies in adults comparing these 2 modalities of ventilation for acute respiratory distress syndrome.
Linker Histones Stimulate HSPA2 ATPase Activity Through NASP Binding and Inhibit CDC2/Cyclin B1 Complex Formation During Meiosis in the Mouse1

In mammalian spermatocytes, cell division cycle protein 2 (CDC2)/cyclin B1 and the chaperone heat shock protein A2 (HSPA2) are required for the G2→M transition in prophase I. Here, we demonstrate that in primary spermatocytes, linker histone chaperone testis/embryo form of nuclear autoantigenic sperm protein (tNASP) binds the heat shock protein HSPA2, which localizes on the synaptonemal complex of spermatocytes. Significantly, the tNASP-HSPA2 complex binds linker histones and CDC2, forming a larger complex. We demonstrate that increasing amounts of tNASP favor tNASP-HSPA2-CDC2 complex formation. Binding of linker histones to tNASP significantly increases HSPA2 ATPase activity and the capacity of tNASP to bind HSPA2 and CDC2, precluding CDC2/cyclin B1 complex formation and, consequently, decreasing CDC2/cyclin B1 kinase activity. Linker histone binding to NASP controls the ability of HSPA2 to activate CDC2 for CDC2/cyclin B1 complex formation; therefore, tNASP's role is to provide the functional link between linker histones and cell cycle progression during meiosis.