Miracle-dz/UniFAR-FTUs huggingface dataset:
Rubisco small subunits from the unicellular green alga Chlamydomonas complement Rubisco‐deficient mutants of Arabidopsis

Summary Introducing components of algal carbon concentrating mechanisms (CCMs) into higher plant chloroplasts could increase photosynthetic productivity. A key component is the Rubisco‐containing pyrenoid that is needed to minimise CO 2 retro‐diffusion for CCM operating efficiency. Rubisco in Arabidopsis was re‐engineered to incorporate sequence elements that are thought to be essential for recruitment of Rubisco to the pyrenoid, namely the algal Rubisco small subunit (SSU, encoded by rbcS) or only the surface‐exposed algal SSU α‐helices. Leaves of Arabidopsis rbcs mutants expressing ‘pyrenoid‐competent’ chimeric Arabidopsis SSUs containing the SSU α‐helices from Chlamydomonas reinhardtii can form hybrid Rubisco complexes with catalytic properties similar to those of native Rubisco, suggesting that the α‐helices are catalytically neutral. The growth and photosynthetic performance of complemented Arabidopsis rbcs mutants producing near wild‐type levels of the hybrid Rubisco were similar to those of wild‐type controls. Arabidopsis rbcs mutants expressing a Chlamydomonas SSU differed from wild‐type plants with respect to Rubisco catalysis, photosynthesis and growth. This confirms a role for the SSU in influencing Rubisco catalytic properties.
Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population

Interleukin-17 plays a crucial role in inflammation-related carcinogenesis. We hypothesize that genetic variants in IL-17 are associated with gastric cancer (GCa) risk, and we genotyped five potentially functional single nucleotide polymorphisms (SNPs) (rs1974226 G > A, rs2275913 A > G, rs3819024 A > G, rs4711998 A > G, and rs8193036 C > T) of IL-17 in 1121 GCa patients and 1216 cancer-free controls in an eastern Chinese population. Logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Meta-analysis and genotype-mRNA expression correlation were performed to further validate positive associations. We found that an increased GCa risk was independently associated with rs1974226 (adjusted OR = 2.60, 95% CI = 1.27–5.32 for AA vs. GG + GA) and rs2275913 (adjusted OR = 1.33, 95% CI = 1.03–1.72 for GA + AA vs. GG), while a decreased GCa risk was independently associated with rs3819024 (adjusted OR = 0.72, 95% CI = 0.54–0.96 for GG vs. AA + AG). Additional meta-analyses confirmed the observed risk association with rs2275913. We also found that two IL-17 haplotypes (G-G-G-A-C) and (A-G-G-A-C) (in the order of rs1974226, rs2275913, rs3819024, rs4711998 and rs8193036) were associated with a reduced GCa risk (adjusted OR = 0.64, 95% CI = 0.46–0.89 and adjusted OR = 0.38, 95% CI = 0.17–0.81, respectively). However, the expression Quantitative Trait Locus (eQTL) analysis for the genotype-phenotype correlation did not find mRNA expression changes associated with either the genotypes. In conclusions, genetic variants of IL-17 are likely to be associated with risk of GCa, and additional larger studies with functional validation are needed to explore the molecular mechanisms underlying the observed associations.
The impact of music on learning and consolidation of novel words

ABSTRACT Music can be a powerful mnemonic device, as shown by a body of literature demonstrating that listening to text sung to a familiar melody results in better memory for the words compared to conditions where they are spoken. Furthermore, patients with a range of memory impairments appear to be able to form new declarative memories when they are encoded in the form of lyrics in a song, while unable to remember similar materials after hearing them in the spoken modality. Whether music facilitates the acquisition of completely new information, such as new vocabulary, remains unknown. Here we report three experiments in which adult participants learned novel words in the spoken or sung modality. While we found no benefit of musical presentation on free recall or recognition memory of novel words, novel words learned in the sung modality were more strongly integrated in the mental lexicon compared to words learned in the spoken modality. This advantage for the sung words was only present when the training melody was familiar. The impact of musical presentation on learning therefore appears to extend beyond episodic memory and can be reflected in the emergence and properties of new lexical representations.
Decline in genital warts diagnoses among young women and young men since the introduction of the bivalent HPV (16/18) vaccination programme in England: an ecological analysis

Background For several decades, diagnoses of genital warts at genitourinary medicine (GUM) clinics in England had been increasing. In 2008, a national human papillomavirus (HPV) vaccination programme was introduced using the bivalent vaccine (types 16 and 18 only). A decrease in genital warts was not anticipated. However, rates of genital warts in GUM clinics have declined significantly since the introduction of the vaccine. Methods Using data from GUM clinics across England, we analysed rates of genital warts by age, gender, sexual orientation and estimated vaccine coverage. Results The reduction in rates of genital warts diagnoses at GUM clinics between 2009 and 2014 was 30.6% among young women aged 15–19 years and 25.4% among same age heterosexual young men. Overall there was an association showing higher warts reduction with increasing vaccination coverage with the largest declines in warts diagnoses observed in young women aged 15 years (50.9%) with the highest vaccination coverage. No such declines were observed in men who have sex with men (MSM) of the same age. Conclusion The results of these ecological analyses are strongly in keeping with the bivalent HPV vaccine providing modest protection against genital warts.
Crack Monitoring Method for an FRP-Strengthened Steel Structure Based on an Antenna Sensor

Fiber-reinforced polymer (FRP) has been increasingly applied to steel structures for structural strengthening or crack repair, given its high strength-to-weight ratio and high stiffness-to-weight ratio. Cracks in steel structures are the dominant hidden threats to structural safety. However, it is difficult to monitor structural cracks under FRP coverage and there is little related research. In this paper, a crack monitoring method for an FRP-strengthened steel structure deploying a microstrip antenna sensor is presented. A theoretical model of the dual-substrate antenna sensor with FRP is established and the sensitivity of crack monitoring is studied. The effects of the weak conductivity of carbon fiber reinforced polymers (CFRPs) on the performance of crack monitoring are analyzed via contrast experiments. The effects of FRP thickness on the performance of the antenna sensor are studied. The influence of structural strain on crack detection coupling is studied through strain–crack coupling experiments. The results indicate that the antenna sensor can detect cracks in steel structures covered by FRP (including CFRP). FRP thickness affects the antenna sensor’s performance significantly, while the effects of strain can be ignored. The results provide a new approach for crack monitoring of FRP-strengthened steel structures with extensive application prospects.
Modal logics with Belnapian truth values

Various four- and three-valued modal propositional logics are studied. The basic systems are modal extensions BK and BS4 of Belnap and Dunn's four-valued logic of firstdegree entailment. Three-valued extensions of BK and BS4 are considered as well. These logics are introduced semantically by means of relational models with two distinct evaluation relations, one for verification (support of truth) and the other for falsification (support of falsity). Axiom systems are defined and shown to be sound and complete with respect to the relational semantics and with respect to twist structures over modal algebras. Sound and complete tableau calculi are presented as well. Moreover, a number of constructive non-modal logics with strong negation are faithfully embedded into BS4, into its three-valued extension B3S4, or into temporal BS4, BtS4. These logics include David Nelson's three-valued logic N3, the four-valued logic N4 bottom, the connexive logic C, and several extensions of bi-intuitionistic logic by strong negation.
INFLUENCE OF PENETRATING CHLORIDES ON THE PORE STRUCTURE OF STRUCTURAL CONCRETE

The present experimental investigation examines the influence of penetrating chlorides on the pore structure of structural concrete. For this purpose, the pore structure of concrete subjected to chloride penetration is compared with that of a similar concrete isolated from chlorides. To achieve the present objective, partially protected concrete slabs were exposed to chlorides for about two years by ponding with an aqueous solution of sodium chloride from the cast face. On completion of the exposure regime, the pore structure of concrete exposed to chlorides was compared with that of the adjacent concrete isolated from chloride intrusion. The concrete subjected to chloride intrusion showed a significant reduction in the number of coarser pores compared to the adjacent concrete isolated from chlorides. Various possibilities, such as degree of carbonation and degree of hydration were examined, step by step, to explain the observed modifications to the pore structure. It is shown that these results strongly suggest that the voluminous chloride-bearing compounds, such as Friedel's salt and calcium chloride, preferentially precipitate in the coarser pores, and thereby decrease the number of coarser pores. Although chloride contamination may thus result in some blocking of the pores in the cover concrete, it is unlikely to enhance the overall durability of the concrete. Further intrusion of chlorides may be hindered for a short time, but it cannot be prevented, and will continue in course of time.
First follow‐up of a breakable stent for implantation in infants dedicated for a life‐long stay

The use of conventional metal stents in infants is severely limited by subsequent somatic growth. The use of a breakable balloon expandable stent (BS) designed for initial implant at small diameters but with properties that allow unlimited dilation in line with growth has potential advantages in this patient group. This study reports our experience with this stent between 2010 and 2014. A total of 17 BS were implanted in 14 infants (mean age 4.8 months). All but one stent was placed into the aorta to treat coarctation.
The relationship between epilithic biofilm stability and its associated meiofauna under two patterns of flood disturbance

Abstract. Habitat stability is an important driver of ecological community composition and development. River epilithic biofilms are particularly unstable habitats for the establishment of benthic communities because they are regularly disturbed by floods. Our aim was to determine the influence of habitat instability on meiobenthic organisms. We hypothesized that hydrologic variables are the most important predictors of meiofauna distribution. We monitored epilithic communities (meiofauna and microalgae) with a high sampling frequency during 2 sampling periods with contrasting hydrodynamic patterns in a temperate river (the Garonne, France). Nematodes and rotifers dominated meiofaunal assemblages. The critical flow velocity threshold for their maintenance in the biofilm was ∼30 cm/s, a result suggesting that meiofauna can resist higher flow velocity within the biofilm than within sediments. Nematode distribution was primarily influenced by the duration of undisturbed periods, whereas rotifer distribution was also correlated with the thickness of the biofilm. During the periods after floods, rotifers were faster colonizers than nematodes. Collectively, our results show that flow regime was an essential driver for biofilm community development.
Fair Resource Allocation for System Throughput Maximization in Mobile Edge Computing

Communication resource allocation is important for improving the performance of users in mobile edge computing (MEC) scenarios. In existing studies, the users in the MEC system typically suffer from unfair resource allocation, which results in the inefficient resource utilization and degraded user performance. To address this challenge, in this paper we propose a fair resource allocation approach to maximize the overall network throughput, under the constraint of each mobile user’s minimum transmission rate. We formulate the problem as a fair Nash bargaining resource allocation game, and the existence and uniqueness of the solution to this game model are analyzed. By adopting the time-sharing variable, we obtain the near optimal bargaining resource allocation strategy for the mixed integer nonlinear programming optimization. The user’s priority is further considered in the iterative implementation of the proposed algorithm by considering the time delay constraint of users. Simulation results show that the proposed scheme outperforms existing methods in terms of resource allocation fairness and overall system throughput.
Efficacy of noninvasive tests in the diagnosis of Helicobacter pylori infection in pediatric patients.

BACKGROUND Helicobacter pylori infection is likely acquired in childhood. Helicobacter pylori is recognized as a cause of gastritis and peptic ulcer. OBJECTIVE To investigate some noninvasive tests, particularly H pylori fecal antigen, for the diagnosis of H pylori infection in comparison with the gold-standard invasive test, esophagogastroduodenoscopy with biopsy. METHODS We studied 250 patients (102 male; age range, 3-18 years) who underwent esophagogastroduodenoscopy with biopsy (histologic examination and rapid urease test) for a suspicious upper gastrointestinal disease; in all of them, fecal H pylori antigen, serum H pylori immunoglobulin G, and cytotoxin-associated gene product A immunoglobulin G were measured. Sensitivity and specificity of noninvasive tests were compared with those of the gold-standard esophagogastroduodenoscopy with biopsy. RESULTS Ninety-three patients (37%) had positive histopathologic (Giemsa staining) and rapid urease test results. The H pylori fecal antigen revealed a sensitivity of 97%, a specificity of 98%, a positive predictive value of 97%, and a negative predictive value of 98%; serum H pylori immunoglobulin G had a sensitivity of 86%, a specificity of 80%, a positive predictive value of 72%, and a negative predictive value of 90%; and serum cytotoxin-associated gene product A immunoglobulin G had a sensitivity of 83%, a specificity of 80%, a positive predictive value of 71%, and a negative predictive value of 89%. CONCLUSIONS Our study demonstrates that among noninvasive and easily applicable tests, particularly in small children, H pylori fecal test is simple, suitable, and has high accuracy for the screening of H pylori-positive patients.
Prevalence of geriatric syndromes among people aged 65 years and older at four community clinics in Moscow

Background Geriatric syndromes (GSs) are common in older adults and have a significant effect on their quality of life, disability, and use of health care resources. Few studies have assessed the prevalence of GSs in Russia. The aim of this study is to assess the prevalence of GSs among older adults living in the community in Moscow. Methods A cross-sectional study was conducted in four community clinics in Moscow. A total of 1,220 patients completed a screening questionnaire, and 356 of them also underwent a comprehensive geriatric assessment (CGA). Results The mean age of the 1,220 participants was 74.9±6.1 years; 75.5% were women. Based on the questionnaire, 58.3% reported visual or hearing impairment, 58.2% cognitive impairment, 46% mood disorder, 42% difficulty walking, 28.3% urinary incontinence, 21.3% traumatic falls (over the previous year), and 12.2% weight loss. The mean number of GSs per patient was 2.9±1.5. Based on CGA, a decline in Instrumental Activity of Daily Living score was identified in 34.8% of the patients, a risk of malnutrition (Mini-Nutritional Assessment score, 17–23.5) in 25.8%, probable cognitive impairment (Mini-Mental State Examination score <25) in 8.6%, and symptoms of depression (15-item Geriatric Depression Scale score >5) in 36.2%. On the whole, patients demonstrated good mobility (average walking speed, 1±0.2 m/s) and hand grip strength (23.9±6.4 kg in women and 39.1±8.3 kg in men), but poor balance (only 39.4% were able to maintain their balance on one leg for 10 s or more). Conclusion The results of this study demonstrate a high prevalence of GSs among community-dwelling people aged 65 years and older in Moscow. The results provide a better understanding of the needs of older adults in Russia and can facilitate planning for medical and social assistance for this population.
Posthemorrhagic ventricular dilatation in preterm infants

Objective To compare neurodevelopmental outcomes of preterm infants with and without intervention for posthemorrhagic ventricular dilatation (PHVD) managed with an “early approach” (EA), based on ventricular measurements exceeding normal (ventricular index [VI] <+2 SD/anterior horn width <6 mm) with initial temporizing procedures, followed, if needed, by permanent shunt placement, and a “late approach” (LA), based on signs of increased intracranial pressure with mostly immediate permanent intervention. Methods Observational cohort study of 127 preterm infants (gestation <30 weeks) with PHVD managed with EA (n = 78) or LA (n = 49). Ventricular size was measured on cranial ultrasound. Outcome was assessed at 18–24 months. Results Forty-nine of 78 (63%) EA and 24 of 49 (49%) LA infants received intervention. LA infants were slightly younger at birth, but did not differ from EA infants for other clinical measures. Initial intervention in the EA group occurred at younger age (29.4/33.1 week postmenstrual age; p < 0.001) with smaller ventricles (VI 2.4/14 mm >+2 SD; p < 0.01), and consisted predominantly of lumbar punctures or reservoir taps. Maximum VI in infants with/without intervention was similar in EA (3/1.5 mm >+2 SD; p = 0.3) but differed in the LA group (14/2.1 mm >+2 SD; p < 0.001). Shunt rate (20/92%; p < 0.001) and complications were lower in EA than LA group. Most EA infants had normal outcomes (>−1 SD), despite intervention. LA infants with intervention had poorer outcomes than those without (p < 0.003), with scores <−2 SD in 81%. Conclusion In preterm infants with PHVD, those with early intervention, even when eventually requiring a shunt, had outcomes indistinguishable from those without intervention, all being within the normal range. In contrast, in infants managed with LA, need for intervention predicted worse outcomes. Benefits of EA appear to outweigh potential risks. Classification of evidence This study provides Class III evidence that for preterm infants with PHVD, an EA to management results in better neurodevelopmental outcomes than a LA.
The Hidden Vulnerability of Distributed Learning in Byzantium

While machine learning is going through an era of celebrated success, concerns have been raised about the vulnerability of its backbone: stochastic gradient descent (SGD). Recent approaches have been proposed to ensure the robustness of distributed SGD against adversarial (Byzantine) workers sending poisoned gradients during the training phase. Some of these approaches have been proven Byzantine-resilient: they ensure the convergence of SGD despite the presence of a minority of adversarial workers. We show in this paper that convergence is not enough. In high dimension $d \gg 1$, an adver\-sary can build on the loss function's non-convexity to make SGD converge to ineffective models. More precisely, we bring to light that existing Byzantine-resilient schemes leave a margin of poisoning of $\Omega\left(f(d)\right)$, where $f(d)$ increases at least like $\sqrt{d~}$. Based on this leeway, we build a simple attack, and experimentally show its strong to utmost effectivity on CIFAR-10 and MNIST. We introduce Bulyan, and prove it significantly reduces the attackers leeway to a narrow $O( \frac{1}{\sqrt{d~}})$ bound. We empirically show that Bulyan does not suffer the fragility of existing aggregation rules and, at a reasonable cost in terms of required batch size, achieves convergence as if only non-Byzantine gradients had been used to update the model.
Regulation of Saccharomyces cerevisiae Flavohemoglobin Gene Expression (*)

The Saccharomyces cerevisiae hemoglobin is a flavoprotein of unknown function. It shares extensive sequence homology with the globin of Candida as well as those of several bacterial species. We have studied its gene regulation in order to better understand its purpose in the cell. Transcriptional analyses indicate that, in sharp contrast to the bacterial globins of Vitreoscilla and Alcaligenes eutrophus, the S. cerevisiae globin message is induced during logarithmic growth and under oxygen-replete conditions. Transcription of the S. cerevisiae hemoglobin gene is positively regulated by the transcription factors heme-activated protein (HAP) 1 and HAP2/3/4, which respond to intracellular heme levels. Anaerobically, there is a low level, HAP-independent induction of hemoglobin mRNA. Unlike other systems influenced by the HAP2/3/4 transcription factor complex, no activation of hemoglobin expression by growth in non-fermentable carbon sources is observed. Flavohemoglobin gene disruption does not alter cell viability or growth in a variety of oxygen conditions and carbon sources. Physical and genetic mapping of the S. cerevisiae flavohemoglobin gene places it on chromosome seven near the formyltetrahydrofolate synthase (ADE3) locus. These data indicate that, despite the high degree of homology, the S. cerevisiae globin may have a function distinct from those proposed for bacterial globins.
The effect of moisture on laboratory-prepared asphalt mixtures

This paper presents the results of a laboratory study conducted to examine the water-induced damage of compacted and loose asphalt-aggregate mixtures from Riyadh, Saudi Arabia. One asphalt cement and two typical aggregate sources (A and B) were used to prepare asphalt mixtures. Test methods used included the Marshall stability ratio, the wet-dry indirect tensile test (Lottman). and coating and stripping tests of uncompacted mixtures (ASTM D 1664, Test Method for Coating and Stripping of Bitumen-Aggregate Mixtures, and ASTM D 3625. Test Method for Effect of Water on Bituminous-Coated Aggregate-Quick Field Test). The test results have shown superior performance of mixtures prepared from Source A aggregate in comparison with Source B Differences in physical properties of the fine fraction between the two sources appear to be responsible for the noted difference in behavior However, mixtures with water susceptible aggregate (Source B) have exhibited improved performance when natural sand. used routinely in combination with crushed sand, is reduced or eliminated. The partial replacement of the crushed limestone filler by cement or lime had positive effects on performance of water-susceptible mixtures. Distinct improvements in 24-h Marshall stability were exhibited when 2% hydrated lime was added. Based on the results, the test methods deployed in this study appear to do a reasonable job in detecting moisture-susceptible pavement mixtures and in evaluating the relative effectiveness of additives in minimizing water damage potential.