Miracle-dz/UniFAR-FTUs huggingface dataset:
Movement Disorders

Merely having the technical ability to perform functional neurosurgery is not sufficient. An understanding of key clinical concepts surrounding movement disorders lies at the heart of becoming a competent functional neurosurgeon in order to ensure correct patient selection and perioperative management. This chapter provides a thorough medical overview of the fundamental clinical aspects, including pathophysiology, diagnosis and medical therapy for the commonest movement disorders encountered in neurosurgical practice: Parkinson’s disease, essential tremor, and dystonia. A brief overview of the surgical management options and outcomes from surgery is discussed. Finally, some of the controversies related to the surgical aspects of movement disorders are examined.
Nonlocal Hierarchical Dictionary Learning using Wavelets and Gradient Histogram Preservation for Image Denoising: A Review

Image denoising is an important image processing task, both as a process itself, and as a component in other processes. The main properties of a good image denoising model are that it will remove noise while preserving edges. Traditionally, linear models have been used. One common approach is to use a Gaussian filter, In spite of the great success of many denoising algorithms; they tend to smooth the fine scale image textures when removing noise, degrading the image visual quality. To address this problem we compare two methods in this paper. The Nonlocal Hierarchical Dictionary Learning using Wavelet (NHDLW) and Gradient Histogram Preservation (GHP),which is large success in denoising. Experimental result shows that the NHDLW get significantly better denoising results especially on an image denoising algorithms on higher noise levels.
mSCTP for soft handover in transport layer

In this letter, we discuss mobile Stream Control Transmission Protocol (SCTP) for soft handover in the transport layer. From the experimentations on triggering rules for Add-IP and Primary-Change during the handover, it is shown that the aggressive Add-IP and conservative Primary-Change rules provide better throughput.
Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage

When pluripotent cells are exposed to a uniform culture environment they routinely display heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression, are linked to differences in the propensity of individual cells to either self-renew or commit towards differentiation. Recent findings have provided new insight into the underlying causes of this heterogeneity, which we summarise here using Nanog, a key regulator of pluripotency, as a model gene. We discuss the role of transcription factor heterogeneity in facilitating the intrinsically dynamic and stochastic nature of the pluripotency network, which in turn provides a potential benefit to a population of cells that needs to balance cell fate decisions.
Cloning and expression of an Aplysia K+ channel and comparison with native Aplysia K+ currents

We describe here the cloning of the Aplysia K+ channel AK01a.AK01a codes for a protein of 515 amino acids, shows considerable homology to other cloned potassium channels, and can be classified as a member of the ShakerK+ channel family. Expression of the AK01a channel in Xenopus oocytes produces a rapidly inactivating outward potassium current (IAK01a) resembling the A-type currents of Drosophila Shaker. Gating for this current is shifted to potentials considerably more positive than the traditional A-currents of Aplysia; we have, however, identified a novel transient potassium current (IAdepoI) in a subset of Aplysia neurons that has similar gating and pharmacological properties to IAK01a.
The effects of vitamin D supplementation on inflammatory biomarkers in patients with asthma: a systematic review and meta-analysis of randomized controlled trials

Background While the association between vitamin D and several inflammatory biomarkers in asthma patients has been extensively reported, it remains unclear whether supplementation modifies these biomarkers. This review aims to evaluate the impact of vitamin D supplementation on inflammatory biomarkers measured in vivo in individuals with asthma. Methods We conducted a systematic review of randomized controlled trials (RCTs) published until November 2022 in six electronic databases evaluating the impact of vitamin D supplementation (any dose, form, administration route, frequency, or duration) compared to placebo in children or adults. The two co-primary outcomes were serum IgE and blood eosinophils reported at the endpoint. Secondary outcomes included other markers of type 2 inflammation (e.g., sputum eosinophils, fractional exhaled nitric oxide, etc.), anti-inflammatory biomarkers (e.g., interleukin (IL)-10, etc.), markers of non-type 2 inflammation (e.g., high-sensitivity C-reactive protein, etc.), and non-specific biomarkers (e.g., macrophages, etc.). Data were aggregated using fixed or random effect models. Results Thirteen RCTs (5 in adults, 5 in pediatric patients, and 3 in mixed age groups) testing doses of vitamin D supplementation ranging from 800 to 400,000 IU over periods of 6 weeks to 12 months were included. Eight studies provided data on serum IgE and four on blood eosinophils. As secondary outcomes, three studies reported on sputum eosinophils, four on FeNO, five on serum IL-10, and two on airway IL-10. Compared to placebo, vitamin D supplementation had no significant effect on serum IgE (Mean difference [MD] [95% CI]: 0.06 [-0.13, 0.26] IU/mL), blood eosinophils (MD [95% CI]: - 0.02 [-0.11, 0.07] 103/μL), or FeNO (MD [95% CI]: -4.10 [-10.95, 2.75] ppb) at the endpoint. However, the vitamin D supplementation group showed higher serum IL-10 levels compared to placebo (MD [95% CI]: 18.85 [1.11, 36.59] pg/ml) at the endpoint. Although data could not be aggregated, narrative synthesis suggested no significant effect of supplementation on sputum eosinophils and IL-10 in both sputum and exhaled breath condensate, at the endpoint. Conclusion Vitamin D supplementation in individuals with asthma was not associated with lower inflammatory biomarkers related to type 2 inflammation. However, it was significantly associated with higher serum IL-10 compared to placebo. Systematic review registration https://www.crd. york.ac. uk/PROSPERO/, identifier CRD42022365666.
An Enzymatic Glucose Sensor Composed of Carbon-Coated Nano Tin Sulfide

In this study, a biosensor, based on a glucose oxidase (GOx) immobilized, carbon-coated tin sulfide (SnS) assembled on a glass carbon electrode (GCE) was developed, and its direct electrochemistry was investigated. The carbon coated SnS (C-SnS) nanoparticle was prepared through a simple two-step process, using hydrothermal and chemical vapor deposition methods. The large reactive surface area and unique electrical potential of C-SnS could offer a favorable microenvironment for facilitating electron transfer between enzymes and the electrode surface. The structure and sensor ability of the proposed GOx/C-SnS electrode were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), Raman spectroscopy, UV–vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), and cyclic voltammetry study (CV).
Maxillofacial injuries among trauma patients undergoing head computerized tomography; A Ugandan experience

Aim: The aim of this study was to investigate epidemiological features of maxillofacial fractures within trauma patients who had head and neck computed tomography (CT) scan at the Mulago National referral hospital. Methods: CT scan records of trauma patients who had head scans at the Department of Radiology over 1-year period were accessed. Data collected included sociodemographic factors, type and etiology of injury, and concomitant maxillofacial injuries. Results: A total of 1330 trauma patients underwent head and neck CT scan in the 1-year study period. Out of these, 130 were excluded due to incomplete or unclear records and no evidence of injury. Of the remaining 1200, 32% (387) had maxillofacial fractures. The median age of the patients with maxillofacial fractures was 28 (range = 18–80) years and 18–27 age group was most common at 47.5%. Road traffic accidents constituted 49.1% of fractures. The single most affected isolated bone was the frontal bone (23%). The number of maxillofacial bones fractured was predicted by age group (df = 3 F = 5.358, P = 0.001), association with other fractures (df = 1 F = 5.317, P = 0.03). Conclusions: Good matched case–control prospective studies are needed to enable us tease out the finer difference in the circumstances and pattern of injury if we are to design appropriate preventive measures.
Learning to Diagnose with LSTM Recurrent Neural Networks

Clinical medical data, especially in the intensive care unit (ICU), consist of multivariate time series of observations. For each patient visit (or episode), sensor data and lab test results are recorded in the patient's Electronic Health Record (EHR). While potentially containing a wealth of insights, the data is difficult to mine effectively, owing to varying length, irregular sampling and missing data. Recurrent Neural Networks (RNNs), particularly those using Long Short-Term Memory (LSTM) hidden units, are powerful and increasingly popular models for learning from sequence data. They effectively model varying length sequences and capture long range dependencies. We present the first study to empirically evaluate the ability of LSTMs to recognize patterns in multivariate time series of clinical measurements. Specifically, we consider multilabel classification of diagnoses, training a model to classify 128 diagnoses given 13 frequently but irregularly sampled clinical measurements. First, we establish the effectiveness of a simple LSTM network for modeling clinical data. Then we demonstrate a straightforward and effective training strategy in which we replicate targets at each sequence step. Trained only on raw time series, our models outperform several strong baselines, including a multilayer perceptron trained on hand-engineered features.
Language Problems in Children With ADHD: A Community-Based Study

OBJECTIVES: To examine the prevalence of language problems in children with attention-deficit/hyperactivity disorder (ADHD) versus non-ADHD controls, and the impact of language problems on the social and academic functioning of children with ADHD. METHODS: Children (6 to 8 years) with ADHD (n = 179) and controls (n = 212) were recruited through 43 Melbourne schools. ADHD was assessed by using the Conners 3 ADHD Index and the Diagnostic Interview Schedule for Children IV. Oral language was assessed by using the Clinical Evaluation of Language Fundamentals, fourth edition, screener. Academic functioning was measured via direct assessment (Wide Range Achievement Test 4) and teacher report (Social Skills Improvement System). Social functioning was measured via parent and teacher report (Strengths and Difficulties Questionnaire; Social Skills Improvement System). Logistic and linear regression models were adjusted for sociodemographic factors and child comorbidities. RESULTS: Children with ADHD had a higher prevalence of language problems than controls after adjustment for sociodemographic factors and comorbidities (odds ratio, 2.8; 95% confidence interval [CI], 1.5 to 5.1). Compared with children with ADHD alone, those with language problems had poorer word reading (mean difference [MD], −11.6; 95% CI, −16.4 to −6.9; effect size, −0.7), math computation (MD, −11.4; 95% CI, −15.0 to −7.7; effect size, −0.8), and academic competence (MD, −10.1; 95% CI, −14.0 to −6.1; effect size, −0.7). Language problems were not associated with poorer social functioning. CONCLUSIONS: Children with ADHD had a higher prevalence of language problems than controls, and language problems in children with ADHD contributed to markedly poorer academic functioning.
Transcriptional analysis of rolling circle replicating plasmid pVT736-1: evidence for replication control by antisense RNA

Several plasmids have been described in Actinobacillus actinomycetemcomitans, a gram-negative coccobacillus. Recently, the nucleotide sequence of pVT736-1, a cryptic plasmid of A. actinomycetemcomitans VT736, was determined. This plasmid possesses all the features necessary for rolling circle replication. The present study involved a transcriptional analysis of pVT736-1. Results of Northern (RNA) blot analyses and primer extension studies indicated that the two open reading frames identified in pVT736-1 are each preceded by at least one promoter. Expression of these promoters varied with growth phase. In addition, an antisense RNA (Cop RNA) appeared to control the synthesis of the putative replication protein. To our knowledge, this is the first rolling circle replicating plasmid isolated from a gram-negative organism that has been subjected to such detailed analysis.
The incidence of rugby-related catastrophic injuries (including cardiac events) in South Africa from 2008 to 2011: a cohort study

Objectives To establish an accurate and comprehensive injury incidence registry of all rugby union-related catastrophic events in South Africa between 2008 and 2011. An additional aim was to investigate correlates associated with these injuries. Design Prospective. Setting The South African amateur and professional rugby-playing population. Participants An estimated 529 483 Junior and 121 663 Senior rugby union (‘rugby’) players (population at risk). Outcome measures Annual average incidences of rugby-related catastrophic injuries by type (cardiac events, traumatic brain and acute spinal cord injuries (ASCIs)) and outcome (full recoveries—fatalities). Playing level (junior and senior levels), position and event (phase of play) were also assessed. Results The average annual incidence of ASCIs and Traumatic Brain Injuries combined was 2.00 per 100 000 players (95% CI 0.91 to 3.08) from 2008 to 2011. The incidence of ASCIs with permanent outcomes was significantly higher at the Senior level (4.52 per 100 000 players, 95% CI 0.74 to 8.30) than the Junior level (0.24 per 100 000 players, 95% CI 0 to 0.65) during this period. The hooker position was associated with 46% (n=12 of 26) of all permanent ASCI outcomes, the majority of which (83%) occurred during the scrum phase of play. Conclusions The incidence of rugby-related catastrophic injuries in South Africa between 2008 and 2011 is comparable to that of other countries and to most other collision sports. The higher incidence rate of permanent ASCIs at the Senior level could be related to the different law variations or characteristics (eg, less regular training) compared with the Junior level. The hooker and scrum were associated with high proportions of permanent ASCIs. The BokSmart injury prevention programme should focus efforts on these areas (Senior level, hooker and scrum) and use this study as a reference point for the evaluation of the effectiveness of the programme.
Seroprevalence and Potential Risk Factors Associated with Neospora spp. Infection among Asymptomatic Horses in Jordan

This study aimed to determine the seroprevalence and to identify risk factors associated with Neospora spp. infection in horses in Jordan. Management related data were collected from each farm and individual horses. Sera from 227 horses from 5 of 6 climatic regions in Jordan were analyzed for the presence of antibodies to Neospora spp. by ELISA kit. The study was performed during spring of 2010. The association between seropositivity and risk factors was analyzed. A total of 7 (3%) of 227 sera had antibodies for Neospora spp. There was a significant regional difference (P=0.018) between the 5 climatic regions. Positive cases were located in Amman and Irbid, while the other regions (Zarqa, Jordan Valley, and Wadi Mousa) had zero prevalence. The use of anthelmintics at least once a year resulted in a significant reduction of the seroprevalence to Neospora spp. (1.6% vs 9.8%). However, this might be a phenomenon by chance and a better hygiene since owners can invest in anthelmintics. Other risk factors such as age, gender, breed, usage, body condition score, grazing, presence of other animals mixed with the horses in the same property, and a history of previous diseases were not significantly associated with the seroprevalence to Neospora spp. infection. This is the first study to report on the presence of Neospora seropositive horses in Jordan. Further studies are warranted to better understand the role of certain risk factors in the transmission of Neospora spp. among horse population and to determine which Neospora spp. are responsible for the infection.
Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization

The contribution of CB1 receptors in the spinal cord to cannabinoid analgesia is still unclear. The objective of this study was to investigate the effect of CB1 receptors on substance P release from primary afferent terminals in the spinal cord. Substance P release was measured as neurokinin 1 (NK1) receptor internalization in lamina I neurons. It was induced in spinal cord slices by dorsal root stimulation and in live rats by a noxious stimulus. In spinal cord slices, the CB1 receptor antagonists AM251, AM281 and rimonabant partially but potently inhibited NK1 receptor internalization induced by electrical stimulation of the dorsal root. This was due to an inhibition of substance P release and not of NK1 receptor internalization itself, because AM251 and AM281 did not inhibit NK1 receptor internalization induced by exogenous substance P. The CB1 receptor agonist ACEA increased NK1 receptor internalization evoked by dorsal root stimulation. The effects of AM251 and ACEA cancelled each other. In vivo, AM251 injected intrathecally decreased NK1 receptor internalization in spinal segments L5 and L6 induced by noxious hind paw clamp. Intrathecal AM251 also produced analgesia to radiant heat stimulation of the paw. The inhibition by AM251 of NK1 receptor internalization was reversed by antagonists of μ‐opioid and GABAB receptors. This indicates that CB1 receptors facilitate substance P release by inhibiting the release of GABA and opioids next to primary afferent terminals, producing disinhibition. This results in a pronociceptive effect of CB1 receptors in the spinal cord.
Spatio-visual memory of children with specific language impairment: evidence for generalized processing problems.

BACKGROUND Children with Specific language Impairment (SLI) have problems with verbal memory, particularly with tasks that have more processing demands. They also have slower speeds of responding for some tasks. AIMS To identify the extent to which young children with SLI would differ in performance from age-matched non-impaired children on a set of spatio-visual memory tasks. It was predicted that if memory limitations of children with SLI extend beyond the verbal domain to other domains, their performance would be significantly poorer on the spatio-visual tasks than that of the comparison group. It was also predicted that they would be slower in responding. METHODS & PROCEDURES Six spatio-visual tasks were used to compare the performance of 21 children with SLI, with a mean age of 54.1 months, and 21 age-matched non-impaired children. The tasks ranged in difficulty from simple recall to a search-based working memory task. All tasks were administered though a laptop computer and responses were non-verbal using a touch screen. OUTCOMES & RESULTS The children with SLI were not significantly slower than the comparison group. However, they were significantly less accurate than the comparison group in recalling patterns, but not in recalling locations. The accuracy for both groups was lower on spatial recall than on pattern recall. The children with SLI were also significantly less able to learn to associate a particular pattern with a particular location, and to have a shorter spatial span. However, on a spatial search task testing working memory, the groups did not differ significantly. CONCLUSIONS The results indicate that the memory limitations of children with SLI are not restricted to verbal memory, and this fact has implications for its aetiology. Intervention programmes for young children with SLI need to extend beyond language in order to help them develop strategies for processing information in different situations.
Tree Structure Compression with RePair

Larsson and Moffat's RePair algorithm is generalized from strings to trees. The new algorithm (TreeRePair) produces straight-line linear context-free tree (SLT) grammars which are smaller than those produced by previous grammar-based compressors such as BPLEX. Experiments show that a Huffman-based coding of the resulting grammars gives compression ratios comparable to the best known XML file compressors. Moreover, SLT grammars can be used as efficient memory representation of trees. Our investigations show that tree traversals over TreeRePair grammars are 14 times slower than over pointer structures and 5 times slower than over succinct trees, while memory consumption is only 1/43 and 1/6, respectively.
Switch Design for Fine-Grained Multicomputers-ona-Chip ∗

Previous studies in network switch design have generally not considered simultaneously both global communication performance and local effects such as critical timing path and chip area. Here a comparison is made among a large number of designs for the purpose of specifying cost-effective communication switches for multicomputers-on-a-chip. We obtain results using two methods: (i) RTL cycle-driven simulations to determine latency and capacity with respect to load, communication pattern, and packet size and (ii) hardware synthesis to a current technology to find the operating frequency and chip area. These are combined to yield performance/area measures for all of the designs; a number of interesting findings are made. One is a deeper understanding of virtual cut-through in terms of deadlock properties and the capability of dynamic load balancing among buffers. We find that virtual cut-through routing is preferable to wormhole routing in more domains than may have been previously realized. Another result is that, after factoring in operating frequency, having more than two lanes per physical channel is counterproductive. Buffer sharing among lanes was found to be useful, but only for certain simple designs under a hot-spot workload. The most important result, perhaps, is the finding that creating cost-effective switches requires that designs be evaluated with respect to both of the performance metrics.