Miracle-dz/UniFAR-FTUs huggingface dataset:
Visualization of Spatiotemporal Energy Dynamics of Hippocampal Neurons by Mass Spectrometry during a Kainate-Induced Seizure

We report the use of matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry combined with capillary electrophoresis (CE) mass spectrometry to visualize energy metabolism in the mouse hippocampus by imaging energy-related metabolites. We show the distribution patterns of ATP, ADP, and AMP in the hippocampus as well as changes in their amounts and distribution patterns in a murine model of limbic, kainate-induced seizure. As an acute response to kainate administration, we found massive and moderate reductions in ATP and ADP levels, respectively, but no significant changes in AMP levels—especially in cells of the CA3 layer. The results suggest the existence of CA3 neuron-selective energy metabolism at the anhydride bonds of ATP and ADP in the hippocampal neurons during seizure. In addition, metabolome analysis of energy synthesis pathways indicates accelerated glycolysis and possibly TCA cycle activity during seizure, presumably due to the depletion of ATP. Consistent with this result, the observed energy depletion significantly recovered up to 180 min after kainate administration. However, the recovery rate was remarkably low in part of the data-pixel population in the CA3 cell layer region, which likely reflects acute and CA3-selective neural death. Taken together, the present approach successfully revealed the spatiotemporal energy metabolism of the mouse hippocampus at a cellular resolution—both quantitatively and qualitatively. We aim to further elucidate various metabolic processes in the neural system.
Social Structure of Coopetition Within a Multiunit Organization: Coordination, Competition, and Intraorganizational Knowledge Sharing

Drawing on a social network perspective of organizational coordination, this paper investigates the effectiveness of coordination mechanisms on knowledge sharing in intraorganizational networks that consist of both collaborative and competitive ties among organizational units. Internal knowledge sharing within a multiunit organization requires formal hierarchical structure and informal lateral relations as coordination mechanisms. Using sociometric techniques, this paper analyzes how formal hierarchical structure and informal lateral relations influence knowledge sharing and how interunit competition moderates the association between such coordination mechanisms and knowledge sharing in a large, multiunit company. Results show that formal hierarchical structure, in the form of centralization, has a significant negative effect on knowledge sharing, and informal lateral relations, in the form of social interaction, have a significant positive effect on knowledge sharing among units that compete with each other for market share, but not among units that compete with each other for internal resources.
1997 CEO PERSPECTIVES ON THE CURRENT STATUS AND FUTURE PROSPECTS OF THE THIRD PARTY LOGISTICS INDUSTRY IN THE UNITED STATES

The market for third party logistics (3PL) services in the U.S. is very dynamic, and important changes continue to occur in both the user and provider communities. The use of such services continues to grow, as do user expectations. As more manufacturers and retailers develop a supply chain management focus they are increasingly turning to 3PL providers for not only a broader range of logistics services, but also more extensive geographic coverage. At the same time, new companies continue to enter the industry, while others fail, consolidate, and form strategic alliances. This article represents a continuation of the 3PL provider research undertaken by the authors during the past four years. Annual surveys of CEOs of twenty-five of the largest companies within the industry, based on annual sales volume, were conducted.
DNA Fingerprinting of Pearls to Determine Their Origins

We report the first successful extraction of oyster DNA from a pearl and use it to identify the source oyster species for the three major pearl-producing oyster species Pinctada margaritifera, P. maxima and P. radiata. Both mitochondrial and nuclear gene fragments could be PCR-amplified and sequenced. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in the internal transcribed spacer (ITS) region was developed and used to identify 18 pearls of unknown origin. A micro-drilling technique was developed to obtain small amounts of DNA while maintaining the commercial value of the pearls. This DNA fingerprinting method could be used to document the source of historic pearls and will provide more transparency for traders and consumers within the pearl industry.
The influence of airline service quality on passenger satisfaction and loyalty : The case of Uganda airline industry

Purpose – The general objective of this study was to examine the influence of airline service quality on passenger satisfaction and loyalty. To achieve this, the research was guided by four specific objectives to which data collection was effected mainly by interview method using fully structured questionnaires. Design/methodology/approach – The study used random sampling technique and it covered 303 respondents on international flights using Entebbe International Airport. Data were analyzed using statistical package for social sciences 16, were χ2 was used to test the hypothesis and regression analysis was performed to examine the relationships between variables. Findings – Findings indicated that the quality of pre-flight, in-flight and post-flight services had a statistically significant effect on passenger satisfaction. In addition to that, passenger satisfaction as a mediating variable also had a significant effect on passenger loyalty. It was noted that passenger satisfaction differed from person to.
Internal consistency and short-term test-retest reliability of the University of Pennsylvania Smell Identification Test

Measures of internal consistency and short-terrn test-retest reliability of the University of Penn- sylvania Smell Identification Test (UPSIT) were determined in 69 people who showed a broad range of test scores at an earlier test administration. In addition, two procedures for releasing the microencapsulated odorants were compared. The split-half reliability coefficients for the two administrations were r = 0.930 and r = 0.957, respectively (p <0.001). The test-retest ( -2-week interval) coefficient was r = 0.949 (p <0.001). Release of the odorants by the tip of a #2 lead pencil resulted in scores equivalent to those obtained by releasing them with #120 sandpaper. These data, along with those collected previously on the long-terrn test-retest reliability (r = 0.918), indicate that the UPSIT is a highly reliable and internally consistent test
Forced Exposure and Psychological Reactance: Antecedents and Consequences of the Perceived Intrusiveness of Pop-Up Ads

Abstract This paper explores forced viewing of “pop-up ads” on the Internet to understand better how viewers come to define ads as irritating and decide to avoid them. Perceived intrusiveness was suggested as the underlying mechanism by which the process occurs. Antecedents of intrusiveness were identified that affect perceptions of ads as interruptions, including congruence of the advertisement content with the current task and intensity of cognition at the moment the ad pops up. The consequences of intrusiveness were shown to be caused by feelings of irritation and ad avoidance. The results provide an understanding of how consumers experience forced exposure situations in interactive environments and highlight implications for advertisers seeking to increase the effectiveness of on-line advertising.
The Criminalization of Immigration in the United States

For more than a century, innumerable studies have confirmed two simple yet powerful truths about the relationship between immigration and crime: immigrants are less likely to commit serious crimes or be behind bars than the native-born, and high rates of immigration are associated with lower rates of violent crime and property crime. This holds true for both legal immigrants and the unauthorized, regardless of their country of origin or level of education. The overwhelming majority of immigrants are not “criminals” by any commonly accepted definition of the term. But immigration policy is often shaped more by fear and stereotype than by empirical evidence. As a result, immigrants have the stigma of “criminality” ascribed to them by an ever-evolving assortment of laws and immigration-enforcement mechanisms. Immigrants are being defined more and more as threats. Whole new classes of “felonies” have been created which apply only to immigrants, deportation has become a punishment for even minor offenses, and policies aimed at trying to end unauthorized immigration have been made more punitive rather than more rational and practical. In short, immigrants themselves are being criminalized.
A Clinical Trial and Extension Study of Infliximab in Korean Patients with Active Rheumatoid Arthritis despite Methotrexate Treatment

Currently, infliximab is given for disease control for active rheumatoid arthritis (RA) patients despite methotrexate treatment. However, the efficacy and safety of infliximab in Korean patients has not been assessed appropriately. Therefore, we performed placebo-controlled, double-blind, randomized study and extension study. One-hundred forty-three patients with active RA were randomized to receive placebo or infliximab 3 mg/kg intravenously at week 0, 2, 6, 14, and 22 with methotrexate maintenance. Primary endpoint was American College of Rheumatology 20% improvement criteria (ACR20) at 30 week. After the clinical trial, patients on placebo (Group 1) and patients on infliximab who showed ACR20 response (Group 2) were treated with infliximab through another 84 week for evaluation of safety. During clinical trial, patients in infliximab group showed higher ACR20 at week 30 than patients in placebo group (50.1% vs 30.6%, P=0.014). A total of 92 patients participated in the extension study. The maintenance rate of infliximab was 62.0% at 84 weeks of extension study. The overall rate of adverse events was not different between Group 1 and Group 2. In Korean patients with active RA despite methotrexate treatment, infliximab in combination with methotrexate is effective and the long-term treatment with infliximab is well tolerated. (ClinicalTrials.gov No. NCT00202852, NCT00732875)
Using fuzzy code search to link code fragments in discussions to source code

When discussing software, practitioners often reference parts of the project's source code. Such references have different motivations, such as mentoring and guiding less experienced developers, pointing out code that needs changes, or proposing possible strategies for the implementation of future changes. The fact that particular parts of a source code are being discussed makes these parts of the software special. Knowing which code is being talked about the most can not only help practitioners to guide important software engineering and maintenance activities, but also act as a high-level documentation of development activities for managers. In this paper, we use clone- detection as specific instance of a code search based approach for establishing links between code fragments that are discussed by developers and the actual source code of a project. Through a case study on the Eclipse project we explore the traceability links established through this approach, both quantitatively and qualitatively, and compare fuzzy code search based traceability linking to classical approaches, in particular change log analysis and information retrieval. We demonstrate a sample application of code search based traceability links by visualizing those parts of the project that are most discussed in issue reports with a Treemap visualization. The results of our case study show that the traceability links established through fuzzy code search- based traceability linking are conceptually different than classical approaches based on change log analysis or information retrieval.
Economic growth at regional level and innovation: Is there any link?

The role of innovation on growth has been analysed to some extent and has been relying mostly on research findings undertaken in developed countries. The aim of this paper is to analyse whether innovation has any role at regional level for potentially explaining the variations in growth among regions, particularly in developing countries. The paper draws upon previous work and to undertake the research, data available from the Enterprise Survey was used to test the potential impact of innovation on economic growth at regional level. The results showed that innovation affects growth using a sample for Romania. This study can constitute the basis for understanding the concept of innovation in relation to regional economic growth and further research in Romania and beyond.
Efficient Keyword Search on Uncertain Graph Data

As a popular search mechanism, keyword search has been applied to retrieve useful data in documents, texts, graphs, and even relational databases. However, so far, there is no work on keyword search over uncertain graph data even though the uncertain graphs have been widely used in many real applications, such as modeling road networks, influential detection in social networks, and data analysis on PPI networks. Therefore, in this paper, we study the problem of top-k keyword search over uncertain graph data. Following the similar answer definition for keyword search over deterministic graphs, we consider a subtree in the uncertain graph as an answer to a keyword query if 1) it contains all the keywords; 2) it has a high score (defined by users or applications) based on keyword matching; and 3) it has low uncertainty. Keyword search over deterministic graphs is already a hard problem as stated in [1], [2], [3]. Due to the existence of uncertainty, keyword search over uncertain graphs is much harder. Therefore, to improve the search efficiency, we employ a filtering-and-verification strategy based on a probabilistic keyword index, PKIndex. For each keyword, we offline compute path-based top-k probabilities, and attach these values to PKIndex in an optimal, compressed way. In the filtering phase, we perform existence, path-based and tree-based probabilistic pruning phases, which filter out most false subtrees. In the verification, we propose a sampling algorithm to verify the candidates. Extensive experimental results demonstrate the effectiveness of the proposed algorithms.
The Influence of Body Position on Cerebrospinal Fluid Pressure Gradient and Movement in Cats with Normal and Impaired Craniospinal Communication

Intracranial hypertension is a severe therapeutic problem, as there is insufficient knowledge about the physiology of cerebrospinal fluid (CSF) pressure. In this paper a new CSF pressure regulation hypothesis is proposed. According to this hypothesis, the CSF pressure depends on the laws of fluid mechanics and on the anatomical characteristics inside the cranial and spinal space, and not, as is today generally believed, on CSF secretion, circulation and absorption. The volume and pressure changes in the newly developed CSF model, which by its anatomical dimensions and basic biophysical features imitates the craniospinal system in cats, are compared to those obtained on cats with and without the blockade of craniospinal communication in different body positions. During verticalization, a long-lasting occurrence of negative CSF pressure inside the cranium in animals with normal cranio-spinal communication was observed. CSF pressure gradients change depending on the body position, but those gradients do not enable unidirectional CSF circulation from the hypothetical site of secretion to the site of absorption in any of them. Thus, our results indicate the existence of new physiological/pathophysiological correlations between intracranial fluids, which opens up the possibility of new therapeutic approaches to intracranial hypertension.
On the Believable Benefits of Low Inflation

This paper reviews the existing theoretical and empirical literature addressing the benefits of low inflation. The ultimate goal is to arrive at a set of benefits in which a monetary authority can have genuine confidence. I argue that the current state of economic research—both empirical and theoretical—provides little basis for believing in significant observable benefits of low inflation such as an increase in the growth rate of real GDP. Moreover, what observable benefits do exist are unlikely to justify a policy of disinflation, even if the transitional costs of disinflation are quite moderate. I conclude that defending a policy of moderate disinflation requires more attention to be paid to the benefits of low inflation that are unobservable in familiar aggregate data. This naturally poses some policy challenges to central banks contemplating a disinflation.
Efficacy of Subgingival Application of Xanthan-based Chlorhexidine Gel Adjunctive to Full-mouth Root Planing Assessed by Real-time PCR: A Microbiologic and Clinical Study

Background and aims The aim of this clinical investigation was to compare clinical and microbiological effectiveness of adjunctive CHX gel in the treatment of periodontitis. Materials and methods Twenty-four subjects with localized or generalized moderate-to-severe chronic periodontitis underwent scaling and root planing. One tooth in each quadrant with a probing depth of >4 mm was chosen for combined gel and SRP, with contralateral tooth as control (SRP treated site). Clinical assessment was carried out at baseline and 1 and 3 months later; microbial assessment was performed by real-time PCR. Periodontal probing depth (PPD) was considered as primary outcome. Results Twenty patients completed the study. Baseline PPDs were 4.90±0.78 and 5.05±0.79 in the SRP and gel groups, respectively (P>0.05), which decreased to 3.67±0.59 and 3.7±0.83 one month after treatment and 3.25±0.65 and 3.38±0.79 three months after treatment. Although values decreased significantly in both groups after one and three months (P=0.001 in the SRP and P=0.001 in the gel group), the inter-group difference was not significant neither at one-month (P=0.47) nor at three-month (P=0.77) intervals. The only clinical parameters exhibiting statistically significant inter-group differences was BOP in both one-month (P=0.004) and three-month (P=0.0001) intervals. All the other clinical measurements showed significant decreases after one and three months in both sites but without inter-group differences. Conclusion Subgingival application of xanthan chlorhexidine gel combined with scaling and root planing reduced bleed-ing of periodontal pockets. Clinical trials to evaluate effectiveness of this gel in aggressive and severe periodontitis modified by systemic factors are suggested.
A Suffix Based Part-of-Speech Tagger for Turkish

In this paper, we present a stochastic part-of-speech tagger for Turkish. The tagger is primarily developed for information retrieval purposes, but it can as well serve as a light-weight PoS tagger for other purposes. The tagger uses a well-established Hidden Markov model of the language with a closed lexicon that consists of fixed number of letters from the word endings. We have considered seven different lengths of word endings against 30 training corpus sizes. Best- case accuracy obtained is 90.2% with 5 characters. The main contribution of this paper is to present a way of constructing a closed vocabulary for part-of-speech tagging effort that can be useful for highly inflected languages like Turkish, Finnish, Hungarian, Estonian, and Czech.
Stable ergodicity of certain linear automorphisms of the torus

We find a class of ergodic linear automorphisms of TN that are stably ergodic. This class includes all non-Anosov ergodic automorphisms when N = 4. As a corollary, we obtain the fact that all ergodic linear automorphism of TN are stably ergodic when N iU 5.
PHISON: Playground for High-level Simulations On Networks

Network simulation has become crucial in the study of telecommunication networks. In this paper we present PHISON (Playground for High-level Simulations On Networks), an easy-to-use discrete-event simulator whose features facilitate the study of diverse phenomena on path-oriented telecommunication networks (i.e. based on connections). A key differentiation feature of PHISON is that it considers the dynamic aspects of such networks at a higher level than previous proposals. Hence, our proposal does not consider protocol data units nor user data packets. Its design considerations and implementation details are presented and, finally, two examples illustrate some of the functionalities of the network simulator.
Does Gender Affect Compensation Among NCAA Basketball Coaches

Due to significant salary differences between male and female employees, NCAA institutions have been accused of gender compensation discrimination. However, we hypothesize that some of these compensation differences may be a result of market forces as opposed to overt discrimination. To test this hypothesis, we created a statistical model incorporating variables affecting NCAA school revenues and coaching performance, and use a linear regression to estimate the statistical impact each variable has on compensation. Our empirical findings do not find employer discrimination of NCAA basketball coaches in 2004-2005.
On the Interface Between Operations and Human Resources Management

Operations management (OM) and human resources management (HRM) historically have been very separate fields. In practice, operations managers and human resource managers interact primarily on administrative issues regarding payroll and other matters. In academia, the two subjects are studied by separate communities of scholars publishing in disjoint sets of journals, drawing on mostly separate disciplinary foundations. Yet, operations and human resources are intimately related at a fundamental level. Operations are the context that often explains or moderates the effects of human resource activities such as pay, training, communications, and staffing. Human responses to OM systems often explain variations or anomalies that would otherwise be treated as randomness or error variance in traditional operations research models. In this paper, we probe the interface between operations and human resources by examining how human considerations affect classical OM results and how operational considerations affect classical HRM results. We then propose a unifying framework for identifying new research opportunities at the intersection of the two fields.
Pregnancy‐related changes: A retrospective review of 278 cervical smears

Pregnancy‐related physiologic changes are well recognized. However, the normal range of changes as reflected in the cervical smear have not been adequately described. Review of 278 abnormal cervical smears from 153 pregnant/preabortal and 125 postpartum/abortal patients revealed the following: 21 high‐grade squamous intraepithelial lesion (HGSIL) cases, 46 low‐grade squamous intraepithelial lesion (LGSIL) cases, 185 atypical squamous cells of undetermined significance (ASCUS) cases, and 26 atypical glandular cells of undetermined significance (AGUS) cases. Surgical correlation (excluding 18 products of conception and 153 placentas) was available in 98 (35%) of the cases. Dysplasia was confirmed on biopsy of 11 cases cytologically diagnosed as HGSIL (7 CINII/III and 4 CIN I), 19 cases cytologically diagnosed as LGSIL (6 CIN II/III and 13 CIN I), 35 cases of ASCUS (4 CIN II/III and 31 CIN I), and 2 cases of AGUS (1 CIN III and 1 CIN I). Decidualization was present in six cervical and three endometrial biopsies. The remaining 180 cases revealed pregnancy‐related changes in most of the atypical groups and a few in the dysplasia groups.