Miracle-dz/UniFAR-FTUs huggingface dataset:
Meetings Individuals , populations , communities and function : the growing field of ectomycorrhizal ecology

The 21st New Phytologist symposium entitled ‘The ecology of ectomycorrhizal fungi’ attracted over 100 participants to Montpellier, France, for a two-day meeting in early December. Marc-André Selosse (Université Montpellier, France) and Ian Alexander (University of Aberdeen, UK) organized the talks around the classic ecological hierarchy of individuals, populations and communities. The meeting also struck a balance between trying to apply broad ecological theory to ectomycorrhizal fungi and investigating the unique aspects of the organisms and the interactions involved.
Phase 1/2 study of mogamulizumab, a defucosylated anti-CCR4 antibody, in previously treated patients with cutaneous T-cell lymphoma.

This phase 1/2 study evaluated the efficacy of mogamulizumab, a defucosylated, humanized, anti-CC chemokine receptor 4 monoclonal antibody, in 41 pretreated patients with cutaneous T-cell lymphoma. No dose-limiting toxicity was observed and the maximum tolerated dose was not reached in phase 1 after IV infusion of mogamulizumab (0.1, 0.3, and 1.0 mg/kg) once weekly for 4 weeks followed by a 2-week observation. In phase 2, patients were dosed with 1.0 mg/kg mogamulizumab according to the same schedule for the first course followed by infusion every 2 weeks during subsequent courses until disease progression. The most frequent treatment-emergent adverse events were nausea (31.0%), chills (23.8%), headache (21.4%), and infusion-related reaction (21.4%); the majority of events were grade 1/2. There were no significant hematologic effects. Among 38 evaluable patients, the overall response rate was 36.8%: 47.1% in Sézary syndrome (n = 17) and 28.6% in mycosis fungoides (n = 21). Eighteen of 19 (94.7%) patients with ≥B1 blood involvement had a response in blood, including 11 complete responses. Given the safety and efficacy of mogamulizumab, phase 3 investigation of mogamulizumab is warranted in cutaneous T-cell lymphoma patients. This trial was registered at www.clinicaltrials. gov as #NCT00888927.
High dietary advanced glycation end products are associated with poorer spatial learning and accelerated Aβ deposition in an Alzheimer mouse model

There is growing evidence of the involvement of advanced glycation end products (AGEs) in the pathogenesis of neurodegenerative processes including Alzheimer's disease (AD) and their function as a seed for the aggregation of Aβ, a hallmark feature of AD. AGEs are formed endogenously and exogenously during heating and irradiation of foods. We here examined the effect of a diet high in AGEs in the context of an irradiated diet on memory, insoluble Aβ42, AGEs levels in hippocampus, on expression of the receptor for AGEs (RAGE), and on oxidative stress in the vasculature. We found that AD‐like model mice on high‐AGE diet due to irradiation had significantly poorer memory, higher hippocampal levels of insoluble Aβ42 and AGEs as well as higher levels of oxidative stress on vascular walls, compared to littermates fed an isocaloric diet. These differences were not due to weight gain. The data were further supported by the overexpression of RAGE, which binds to Aβ42 and regulates its transport across the blood–brain barrier, suggesting a mediating pathway. Because exposure to AGEs can be diminished, these insights provide an important simple noninvasive potential therapeutic strategy for alleviating a major lifestyle‐linked disease epidemic.
Overconfidence is a Social Signaling Bias

Evidence from psychology and economics indicates that many individuals overestimate their ability, both absolutely and relatively. We test three different theories about observed relative overconfidence. The first theory notes that simple statistical comparisons (for example, whether the fraction of individuals rating own skill above the median value is larger than half) are compatible (Benoit and Dubra, 2007) with a Bayesian model of updating from a common prior and truthful statements. We show that such model imposes testable restrictions on relative ability judgments, and we test the restrictions. Data on 1,016 individuals' relative ability judgments about two cognitive tests rejects the Bayesian model. The second theory suggests that self-image concerns asymmetrically affect the choice to get new information about one’s abilities, and this asymmetry produces overconfidence (K? szegi, 2006; Weinberg, 2006). We test an important specific prediction of these models: individuals with a higher belief will be less likely to search for further information about their skill, because this information might make this belief worse. Our data also reject this prediction. The third theory is that overconfidence is induced by the desire to send positive signals to others about one’s own skill; this suggests either a bias in judgment, strategic lying, or both. We provide evidence that personality traits strongly affect relative ability judgments in a pattern that is consistent with this third theory. Our results together suggest that overconfidence in statements is most likely to be induced by social concerns than by either of the other two factors.
4-phenylbutyrate Mitigates Fluoride-Induced Cytotoxicity in ALC Cells

Chronic fluoride over-exposure during pre-eruptive enamel development can cause dental fluorosis. Severe dental fluorosis is characterized by porous, soft enamel that is vulnerable to erosion and decay. The prevalence of dental fluorosis among the population in the USA, India and China is increasing. Other than avoiding excessive intake, treatments to prevent dental fluorosis remain unknown. We previously reported that high-dose fluoride induces endoplasmic reticulum (ER) stress and oxidative stress in ameloblasts. Cell stress induces gene repression, mitochondrial damage and apoptosis. An aromatic fatty acid, 4-phenylbutyrate (4PBA) is a chemical chaperone that interacts with misfolded proteins to prevent ER stress. We hypothesized that 4PBA ameliorates fluoride-induced ER stress in ameloblasts. To determine whether 4PBA protects ameloblasts from fluoride toxicity, we analyzed gene expression of Tgf-β1, Bcl2/Bax ratio and cytochrome-c release in vitro. In vivo, we measured fluorosis levels, enamel hardness and fluoride concentration. Fluoride treated Ameloblast-lineage cells (ALC) had decreased Tgf-β1 expression and this was reversed by 4PBA treatment. The anti-apoptotic Blc2/Bax ratio was significantly increased in ALC cells treated with fluoride/4PBA compared to fluoride treatment alone. Fluoride treatment induced cytochrome-c release from mitochondria into the cytosol and this was inhibited by 4PBA treatment. These results suggest that 4PBA mitigates fluoride-induced gene suppression, apoptosis and mitochondrial damage in vitro. In vivo, C57BL/6J mice were provided fluoridated water for six weeks with either fluoride free control-chow or 4PBA-containing chow (7 g/kg 4PBA). With few exceptions, enamel microhardness, fluorosis levels, and fluoride concentrations of bone and urine did not differ significantly between fluoride treated animals fed with control-chow or 4PBA-chow. Although 4PBA mitigated high-dose fluoride toxicity in vitro, a diet rich in 4PBA did not attenuate dental fluorosis in rodents. Perhaps, not enough intact 4PBA reaches the rodent ameloblasts necessary to reverse the effects of fluoride toxicity. Further studies will be required to optimize protocols for 4PBA administration in vivo in order to evaluate the effect of 4PBA on dental fluorosis.
Epidemiology of medical error

Newspaper and television stories of catastrophic injuries occurring at the hands of physicians spotlight the problem of medical error but provide little insight into its nature or magnitude.1 Physicians, patients, and policymakers may underestimate the magnitude of risk and the extent of harm. We review the epidemiology of medical error, concentrating primarily on the prevalence and consequences of error, which types are most common, which physicians make errors, and the risk factors that increase the likelihood of injury from error.
Media Disruption and Revolutionary Unrest: Evidence From Mubarak's Quasi-Experiment

Conventional wisdom suggests that universal lapses in media connectivity—for example, disruption of Internet and cell phone access—have a negative effect on political mobilization. On the contrary, I argue that sudden and ubiquitous interruption of mass communication can facilitate revolutionary mobilization and proliferate decentralized contention. A dynamic threshold model for participation in network collective action is used to demonstrate that full connectivity in a social network can hinder revolutionary action. I exploit a decision by Mubarak's regime to disrupt Internet and mobile communication during the 2011 Egyptian uprising to provide an empirical test for the hypothesis. An interrupted time series inference strategy is used to gauge the impact of media disruption on the dispersion of the protests. The evidence is corroborated using historical, anecdotal, and statistical accounts. In line with the theory, the results of a survey among Egyptian protesters show a significant decline in the percentage of participation in Tahrir Square as a fraction of total participation across Cairo on the first day of media disruption.
Application of the 2010 McDonald criteria for the diagnosis of multiple sclerosis in a Spanish cohort of patients with clinically isolated syndromes

Background: Recently the International Panel on Diagnosis of Multiple Sclerosis (MS) has proposed new magnetic resonance imaging (MRI) criteria for the diagnosis of MS in patients with clinically isolated syndromes (CIS). We aimed to evaluate the accuracy of these new criteria for lesions dissemination in space (DIS) and time (DIT), from a single MRI scan, to predict conversion from CIS to clinically definite MS. Methods: We studied 67 CIS patients with baseline MRI performed within the first 3 months after onset. The follow-up was of at least 24 months. The sensitivity, specificity and accuracy of Barkhof–Tintoré criteria and the new proposed MRI criteria for DIS and DIT were calculated with SPSS v.15. 0. Results: The mean age for clinical onset was 30 years and 64% of patients were female. The overall conversion rate was 74%. In our cohort, Barkhof–Tintoré criteria showed a sensitivity of 71.43%, a specificity of 66.67%, with an accuracy of 73.1%. New DIS criteria showed a sensitivity of 85.71%, a specificity of 64.71% and an accuracy of 80.30%. We also evaluated the new DIT criteria with a single MRI scan in 54 patients with baseline scans that included gadolinium-enhanced images. The sensitivity of the test was 52.63% with a specificity of 75.00% and an accuracy of 59.26%. Conclusion: New DIS criteria are simpler and more sensitive than previous criteria. The sensitivity of DIT criterion using a single MRI scan was rather low, as other previous studies showed, reflecting its stringency, but it could improve the accuracy of early MS diagnosis in that group of patients with typical CIS and gadolinium-enhancing and non-enhancing lesions on their baseline scans. These results reinforce their use in MS diagnosis.
2 ON THE IMPORTANCE OF INHIBITION : CENTRAL AND PERIPHERAL MANIFESTATIONS OF NONLINEAR INHIBITORY PROCESSES IN NEURAL SYSTEMS

ᮀ Inhibitory processes provide for the sculpting of neural action at all levels of the neu-raxis. Importantly, it appears that this inhibitory function may be decidedly nonlinear in nature such that a little inhibition goes a long way in guiding the behavior of neural systems. The neural control of the heart is used as a model system to illustrate the nature of this nonlinear inhibitory control. Similar inhibitory processes function in the prefrontal cortex, in the amygdala, and between the prefrontal cortex and the amygdala in the service of organism flexibility, adaptability, and health. It is suggested that a dynamical systems perspective of neural regulation involving nonlinear inhibitory processes may be a useful framework within which to investigate the complex behavior associated with health and disease.
Bias-variance tradeoff in hybrid generative-discriminative models

Given any generative classifier based on an inexact density model, we can define a discriminative counterpart that reduces its asymptotic error rate, while increasing the estimation variance. An optimal bias-variance balance might be found using hybrid generative-discriminative (HGD) approaches. In these paper, these methods are defined in a unified framework. This allow us to find sufficient conditions under which an improvement in generalization performances is guaranteed. Numerical experiments illustrate the well fondness of our statements.
Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment

Scratch-wound assays are commonly used to study the ability of cells to polarize and migrate. In a previous study we showed that Golgi reorientation in response to a scratch wound is actin-dependent in NIH 3T3 cells but not in astrocytes. In this investigation, to study cell polarity and motility further, we used the polarization of the Golgi and microtubule organizing center (MTOC), as well as the ability of NIH 3T3 cells to migrate, in a scratch-wound assay. Unlike Golgi polarization, MTOC polarization was not dependent on actin, the Arp2/3 complex or Wiskott-Aldrich syndrome protein (WASP)-family proteins. By contrast, disruption of microtubules inhibited MTOC polarity, but not Golgi polarity. Migration was found to be dependent both on actin and microtubules. Expression of the formin-homology 2 (FH2) region of mDia1 inhibited Golgi polarization and migration but not MTOC polarization. Similarly, ST638, a Src inhibitor, inhibited Golgi polarization and migration but not MTOC polarization, whereas expression of the actin regulator IRSp53 only inhibited cell migration. Interestingly, the inhibition of cell migration by the mDia1 FH2 domain could be overcome by addition of Y27632, an inhibitor of ROCK (Rho-associated kinase). In fact, in the presence of ROCK inhibitor, cell migration was accelerated but polarization of both the Golgi and MTOC were inhibited. These data show that, in NIH 3T3 cells, different aspects of cell polarization and migration occur by different mechanisms, and both actin and microtubule networks are required. In addition, this study indicates that MTOC and Golgi polarization events are separately controlled.
Collaborative Alliances: Moving from Practice to Theory

The Journal of Applied Behavioral Science presents two special issues on collaborative alliances that examine the contributions and limits of existing theories for explaining collaboration, and that clarify and expand our understanding of this phenomenon. In this introduction, the following major theoretical perspectives are applied to explain collaboration and collaborative alliances: resource dependence theory; corporate social performance/institutional economics theory; strategic management/social ecology theory; macroeconomics theory; institutional/negotiated order theory; and political theory. The nine case research articles in the two special issues analyze a wide variety of collaborative alliances and provide unique insights. The articles `contributions, the levels of analysis they focus on, and the ways they address three broad issues of collaborative alliances -preconditions, process, and outcomes -are discussed. No single theoretical perspective provides an adequate foundation for a general theory of collaboration, but the articles point the way to the construction of such a theory.
Physical Activity Lessons in Preschools

A review of the current literature indicates that childhood obesity is on the rise. What is more disconcerting is that this epidemic has significantly affected the preschool-age population, with the percentage of overweight children increasing from 5.0% to 12.4%, as indicated by National Health and Nutrition Examination Survey (NHANES) surveys taken in 1976 to 1980 and in 2003 to 2006. To this end, the current study examines the incorporation (or lack thereof), of health-related physical activity in 40 preschools in Indiana. Participants were asked to complete a questionnaire to indicate what health-related physical activity they were incorporating in their classroom curricula. In addition, they listed the number of times they were incorporating such activities and why they incorporated them. Percentages of health activities were calculated based on the total number of responses for individual physical activities. Seventy-one percent of the respondents reported incorporating physical activities in their class schedules. Respondents incorporated such activities as outdoor or out-of-class play, motor development activities (e.g., yoga), showing exercise videos, and bringing in physical activity experts into the classroom. Although preschool teachers are making efforts to increase physical activity in the classroom, such efforts need to be intensified.
Motivation to work, work commitment and man's will to meaning

Victor Frankl (1969, 1972, 1975, 1984a, 1984b) postulated that man’s search for meaning is the primary motivational force in his life. If this postulation is true for life in general, it was expected that this would also be true for a person’s work life. The objective of the present research was to explore whether relationships exist between man's "will to meaning" as defined in Frankl’s logotherapy, with work aspects such as work commitment and work motivation. The present research also investigated the relationships between meaning and certain work related biographic/lifestyle variables. Survey research was conducted with a sample of 458 management level employees from six large companies from different industrial sectors in South Africa. Seven standardised, well-validated instruments were used to measure the respective constructs. The following constructs were measured: meaning, work involvement, work commitment (represented by work values, job involvement and career commitment), and work motivation (represented by intrinsic motivation and goal orientation). The data was analysed by means of Principal Factor Analysis, NonParametric Analysis of Variance, Partial Correlation Analysis, Stepwise Multiple Regression Analysis, and Structural Equations Modelling. These instruments were revalidated as part of the present study. The results of this research indicated that meaning was significantly associated with career commitment. The results also indicated that meaning was significantly associated with work motivation, as measured through intrinsic motivation and goal orientation. Furthermore, meaning generally showed statistically significant relationships with work orientation and lifestyle related variables. In contrast, meaning did not show statistically significant relationships with work values, job involvement or work involvement. Meaning also did not show statistically significant relationships with Biographical/demographic type variables.
Club Drug Use and Risky Sex Among Gay and Bisexual Men in New York City

SUMMARY In New York City, the use of “club drugs” such as MDMA, crystal methamphetamine, ketamine, GHB, and cocaine has been identified as an emerging problem among subgroups of the gay and bisexual male community. More alarming is the mounting empirical evidence showing how club drug use is associated with the rising prevalence of unsafe sexual behaviors among members of this community, leading to increasing HIV incidence. Studies have been conducted at the Center for HIV Educational Studies and Training (CHEST) at Hunter College of City University of New York that address prevalence of club drug use and unsafe sexual behaviors among various samples of gay and bisexual men in New York City. Creative educational interventions as well as clinical strategies using Motivational Interviewing and Cognitive Behavioral Therapy may be useful for clinicians and other health care practitioners by helping clients develop skills to reduce club drug use and risky sex.
Quantitative morphologic classification of layer 5 neurons from mouse primary visual cortex

The understanding of any neural circuit requires the identification and characterization of all its components. Morphologic classifications of neurons are, therefore, of central importance to neuroscience. We use a quantitative method to classify neurons from layer 5 of mouse primary visual cortex, based on multidimensional clustering. To reconstruct neurons, we used Golgi impregnations and biocytin injections, as well as DiOlistics, a novel technique of labeling neurons with lipophilic dyes. We performed computerized 3‐D reconstructions of 158 layer 5 cells to measure a series of morphologic variables. Principal component analysis and cluster analysis were used for the classification of cell types. Five major classes of cells were found: group 1 includes large pyramidal neurons with apical dendrites that reach layer 1 with an apical tuft; group 2 consists of short pyramidal neurons and large multipolar cells with “polarized” dendritic trees; group 3 is composed of less extensive pyramidal neurons; group 4 includes small cells; and group 5 includes another set of short pyramidal neurons in addition to “atypically oriented” cells. Our sample included a relatively homogeneous group of 27 neurons that project to the superior colliculus, which clustered mainly in group 1, thus supporting the validity of the classification. Cluster analysis of neuronal morphologies provides an objective method to quantitatively define different neuronal phenotypes and may serve as a basis for describing neocortical circuits. J. Comp. Neurol. 461:415–428, 2003. © 2003 Wiley‐Liss, Inc.
The maize disease resistance gene Htn1 against northern corn leaf blight encodes a wall-associated receptor-like kinase

Significance Northern corn leaf blight (NCLB) is one of the most devastating fungal diseases of maize. The Htn1 disease resistance gene confers quantitative field resistance against most NCLB isolates. Here we show that Htn1 encodes a putative wall-associated receptor-like kinase (RLK). RLKs act as important components of the first tier of the plant innate immune system by perceiving pathogen- or host-derived elicitors on the cell surface. RLKs are often associated with resistance to nonadapted pathogens and are a component of nonhost resistance. Our work demonstrates that the Htn1-RLK plays an important role in host resistance against adapted fungal pathogens. Northern corn leaf blight (NCLB) caused by the hemibiotrophic fungus Exserohilum turcicum is an important foliar disease of maize that is mainly controlled by growing resistant maize cultivars. The Htn1 locus confers quantitative and partial NCLB resistance by delaying the onset of lesion formation. Htn1 represents an important source of genetic resistance that was originally introduced from a Mexican landrace into modern maize breeding lines in the 1970s. Using a high-resolution map-based cloning approach, we delimited Htn1 to a 131.7-kb physical interval on chromosome 8 that contained three candidate genes encoding two wall-associated receptor-like kinases (ZmWAK-RLK1 and ZmWAK-RLK2) and one wall-associated receptor-like protein (ZmWAK-RLP1). TILLING (targeting induced local lesions in genomes) mutants in ZmWAK-RLK1 were more susceptible to NCLB than wild-type plants, both in greenhouse experiments and in the field. ZmWAK-RLK1 contains a nonarginine-aspartate (non-RD) kinase domain, typically found in plant innate immune receptors. Sequence comparison showed that the extracellular domain of ZmWAK-RLK1 is highly diverse between different maize genotypes. Furthermore, an alternative splice variant resulting in a truncated protein was present at higher frequency in the susceptible parents of the mapping populations compared with in the resistant parents. Hence, the quantitative Htn1 disease resistance in maize is encoded by an unusual innate immune receptor with an extracellular wall-associated kinase domain. These results further highlight the importance of this protein family in resistance to adapted pathogens.