Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive evaluation of carboxylated nanodiamond as a topical drug delivery system

The best strategy in the development of topical drug delivery systems may be to facilitate the permeation of drugs without any harmful effects, while staying on the skin surface and maintaining stability of the system. Nanodiamonds (NDs) play a key role with their excellent physicochemical properties, including high biocompatibility, physical adsorption, reactive oxygen species (ROS) scavenging capability, and photostabilizing activity. Z-average sizes of carboxylated ND (ND–COOH) agglutinate decreased significantly as the pH increased. Fluorescein-conjugated ND was observed only on the stratum corneum, and no sample diffused into the dermal layer even after 48 hours. Moreover, ND–COOH and ND–COOH/eugenol complex did not show significant toxic effects on murine macrophage cells. ND improved in vitro skin permeation >50% acting as a “drug reservoir” to maintain a high drug concentration in the donor chamber, which was supported by quartz crystal microbalance results. Moreover, ND–COOH could adsorb a drug amount equivalent to 80% of its own weight. A photostability study showed that ND–COOH increased the photostability ~47% with regard to rate constant of the eugenol itself. A significant decrease in ROS was observed in the ND–COOH and ND–COOH/eugenol complex compared with the negative control during intracellular ROS assay. Moreover, ROS and cupric reducing antioxidant capacity evaluation showed that ND–COOH had synergistic effects of antioxidation with eugenol. Therefore, ND–COOH could be used as an excellent topical drug delivery system with improved permeability, higher stability, and minimized safety issue.
Pharmacology and Cancer Biology, 2 Microbiology And

The immunosuppressants cyclosporin A (CsA) and FK506 inhibit the protein phosphatase calcineurin and block T-cell activation and transplant rejection. Calcineurin is conserved in microorganisms and plays a general role in stress survival. CsA and FK506 are toxic to several fungi, but the common human fungal pathogen Candida albicans is resistant. However, combination of either CsA or FK506 with the antifungal drug ¯uconazole that perturbs synthesis of the membrane lipid ergosterol results in potent, synergistic fungicidal activity. Here we show that the C.albicans FK506 binding protein FKBP12 homolog is required for FK506 synergistic action with ¯uconazole. A mutation in the calcineurin B regulatory subunit that confers dominant FK506 resistance (CNB1-1/CNB1) abolished FK506±¯uconazole synergism. Candida albi-cans mutants lacking calcineurin B (cnb1/cnb1) were found to be viable and markedly hypersensitive to ¯u-conazole or membrane perturbation with SDS. FK506 was synergistic with ¯uconazole against azole-resistant C.albicans mutants, against other Candida species, or when combined with different azoles. We propose that calcineurin is part of a membrane stress survival pathway that could be targeted for therapy.
Delta- and gamma-tocotrienol isomers are potent in inhibiting inflammation and endothelial activation in stimulated human endothelial cells

Background Tocotrienols (TCTs) are more potent antioxidants than α-tocopherol (TOC). However, the effectiveness and mechanism of the action of TCT isomers as anti-atherosclerotic agents in stimulated human endothelial cells under inflammatory conditions are not well established. Aims 1) To compare the effects of different TCT isomers on inflammation, endothelial activation, and endothelial nitric oxide synthase (eNOS). 2) To identify the two most potent TCT isomers in stimulated human endothelial cells. 3) To investigate the effects of TCT isomers on NFκB activation, and protein and gene expression levels in stimulated human endothelial cells. Methods Human umbilical vein endothelial cells were incubated with various concentrations of TCT isomers or α-TOC (0.3–10 µM), together with lipopolysaccharides for 16 h. Supernatant cells were collected and measured for protein and gene expression of cytokines (interleukin-6, or IL-6; tumor necrosis factor-alpha, or TNF-α), adhesion molecules (intercellular cell adhesion molecule-1, or ICAM-1; vascular cell adhesion molecule-1, or VCAM-1; and e-selectin), eNOS, and NFκB. Results δ-TCT is the most potent TCT isomer in the inhibition of IL-6, ICAM-1, VCAM-1, and NFκB, and it is the second potent in inhibiting e-selectin and eNOS. γ-TCT isomer is the most potent isomer in inhibiting e-selectin and eNOS, and it is the second most potent in inhibiting is IL-6, VCAM-1, and NFκB. For ICAM-1 protein expression, the most potent is δ-TCT followed by α-TCT. α- and β-TCT inhibit IL-6 at the highest concentration (10 µM) but enhance IL-6 at lower concentrations. γ-TCT markedly increases eNOS expression by 8–11-fold at higher concentrations (5–10 µM) but exhibits neutral effects at lower concentrations. Conclusion δ- and γ-TCT are the two most potent TCT isomers in terms of the inhibition of inflammation and endothelial activation whilst enhancing eNOS, possibly mediated via the NFκB pathway. Hence, there is a great potential for TCT isomers as anti-atherosclerotic agents.
Pengaruh Independensi, Kompetensi, Integritas, Objektivitas dan Pengalaman Kerja Terhadap Kualitas Audit (Studi pada Kantor Akuntan Publik di Jawa Tengah)

This study aimed to analyze the influence of the independence, competence, integrity, objectivity, and work experience on audit quality. This study was conducted by distributing questionnaires to KAP in Central Java. Total sample is 46 respondents working in 5 KAP. This study is a quantitative study. Samples was determined using a convenience sampling. Hypothesis testing using multiple linear regression with SPSS version 20. All the variables in this study was measured by Likert Scale. The results of this study indicate that all independent variables have an effect on audit quality. The t-test showed the variables of independence, competence, integrity, objectivity, and work experience affect the quality of audit. The results obtained R2 values of 0.613 which means that 61.3% of variables that affect the quality of the audit could be explained by the variable independence, competence, integrity, objectivity, work experience, while the remaining 38.7% is explained by variabels outside the model.
Effects of Consultation on Professional Learning Communities

ABSTRACT School psychologists can impact student outcomes by consulting with teams around data. The current study investigated the effects of consultation with Professional Learning Communities (PLC) teacher teams. The study included four teacher teams, observing their PLC practices and providing consultation. Each team was observed with a PLC-implementation rubric using a multiple baseline design, including baseline, intervention, and maintenance phases. The specific areas of observation on the PLC Implementation Rubric were “How Effective Teams Work,” “What Students Need to Know and Do,” and “Assessment for/of Learning. ” The data were visually analyzed and a nonoverlap of all pairs effect size was computed. During the intervention phase, each team chose an item to focus on from the same observation strand. Therefore, the data were analyzed on the single strand and the three strands taken together. The results from the study indicated a change in PLC implementation occurred when consultation was added, and the change was maintained after consultation ended. However, the improvements for each team during the intervention and maintenance phases were small in comparison to the baseline phase. In addition, teams displayed greater improvements in implementation fidelity on the single strand in comparison to the three strands taken together. Future research is needed to determine the impact of consultation with PLCs on student outcomes. Implications for research and practice, limitations, and future directions are discussed.
The impact of bandwidth constraints on the energy consumption of Wireless Sensor Networks

Optimization of flows to maximize Wireless Sensor Network (WSN) lifetime is a problem already investigated in various aspects. However, most studies ignored the effects of finite bandwidth. As source data rate of sensor nodes increases, flow patterns that balance energy dissipation optimally might need more bandwidth than available. As a result, ignoring bandwidth limitations may lead to infeasible solutions. In this study, we make a comprehensive evaluation of the impacts of finite bandwidth by building a linear programming framework. The objective is the minimization of the energy expenditure in the maximum energy-dissipating node to achieve the maximum lifetime under bandwidth constraints. Our analysis reveals that energy consumption values may stay constant until a threshold data rate is reached. But, after the threshold the energy values increase because suboptimal paths are used due to bandwidth constraints. The bandwidth for optimal energy dissipation is limited approximately by twice the minimum bandwidth requirement.
Facility-based active management of the third stage of labour: assessment of quality in six countries in sub-Saharan Africa

Abstract Objective To assess the quality of facility-based active management of the third stage of labour in Ethiopia, Kenya, Madagascar, Mozambique, Rwanda and the United Republic of Tanzania. Methods Between 2009 and 2012, using a cross-sectional design, 2317 women in 390 health facilities were directly observed during the third stage of labour. Observers recorded the use of uterotonic medicines, controlled cord traction and uterine massage. Facility infrastructure and supplies needed for active management were audited and relevant guidelines reviewed. Findings Most (94%; 2173) of the women observed were given oxytocin (2043) or another uterotonic (130). The frequencies of controlled cord traction and uterine massage and the timing of uterotonic administration showed considerable between-country variation. Of the women given a uterotonic, 1640 (76%) received it within three minutes of the birth. Uterotonics and related supplies were generally available onsite. Although all of the study countries had national policies and/or guidelines that supported the active management of the third stage of labour, the presence of guidelines in facilities varied across countries and only 377 (36%) of 1037 investigated providers had received relevant training in the previous three years. Conclusion In the study countries, quality and coverage of the active management of the third stage of labour were high. However, to improve active management, there needs to be more research on optimizing the timing of uterotonic administration. Training on the use of new clinical guidelines and implementation research on the best methods to update such training are also needed.
A highly-efficient wait-free universal construction

We present a new simple wait-free universal construction, called Sim, that uses just a Fetch&Add and an LL/SC object and performs a constant number of shared memory accesses. We have implemented SIM in a real shared-memory machine. In theory terms, our practical version of SIM, called P-SIM, has worse complexity than its theoretical analog; in practice though, we experimentally show that P-SIM outperforms several state-of-the-art lock-based and lock-free techniques, and this given that it is wait-free, i.e., that it satisfies a stronger progress condition than all the algorithms it outperforms. We have used P-SIM to get highly-efficient wait-free implementations of stacks and queues. Our experiments show that our implementations outperform the currently state-of-the-art shared stack and queue implementations which ensure only weaker progress properties than wait-freedom.
Damping of tensor modes in cosmology

An analytic formula is given for the traceless transverse part of the anisotropic stress tensor due to free streaming neutrinos, and used to derive an integro-differential equation for the propagation of cosmological gravitational waves. The solution shows that anisotropic stress reduces the squared amplitude by 35.6% for wavelengths that enter the horizon during the radiation-dominated phase, independent of any cosmological parameters. This decreases the tensor temperature and polarization correlation functions for these wavelengths by the same amount. The effect is less for wavelengths that enter the horizon at later times. At the longest wavelengths the decrease in the tensor correlation functions due to neutrino free streaming ranges from 10.7% for ${\ensuremath{\Omega}}_{M}{h}^{2}=0.1$ to 9.0% for ${\ensuremath{\Omega}}_{M}{h}^{2}=0.15. $ An appendix gives a general proof that tensor as well as scalar modes satisfy a conservation law for perturbations outside the horizon, even when the anisotropic stress tensor is not negligible.
Derivation of Sea Surface Wind Directions from TerraSAR-X Data Using the Local Gradient Method

Derivation of sea surface wind direction is a key step of sea surface wind retrieval from spaceborne Synthetic Aperture Radar (SAR) data. This technical note describes an implementation of the Local Gradient (LG) method to derive sea surface wind directions at a scale of a few kilometers from X-band spaceborne SAR TerraSAR-X (TS-X) data in wide swath mode. The 180° ambiguity in the derived sea surface wind direction is automatically eliminated using a single reference wind direction from external data sources. Several typical cases acquired in the North Sea were presented to demonstrate the derivation of sea surface wind direction under different wind situations using this method. The derived sea surface wind direction were further compared to atmospheric model prediction results. In addition, a practical method is introduced to address ambiguity in the derived sea surface wind directions using the LG method in a typhoon case with rotating surface wind structure. By interpolating the derived wind directions at a scale of kilometers, sea surface wind speeds with a spatial resolution of 500 m are subsequently retrieved using the X-band SAR sea surface wind Geophysical Model Function (GMF). The approach accomplished by combining the LG method with the X-band GMF for deriving sea surface wind in high spatial resolution demonstrates its potential for operational service.
Reserve Bank of St . Louis Working Paper Series Innovation , Diffusion , and Trade : Theory and Measurement

I develop a multicountry-model in which economic growth is driven mainly by domestic innovation and the adoption of foreign technologies embodied in traded intermediate goods. Fitting the model to data on innovation, output per capita, and trade in varieties for the period 1996-2007, I estimate the costs of both domestic innovation and adopting foreign innovations, and then decompose the sources of economic growth around the world. I find that the adoption channel has been especially important in developing countries, and accounts for about 65% of their “embodied” growth. Developed countries grow mainly through the domestic innovation channel, which explains 85% of their “embodied” growth. A counterfactual exercise shows that if all countries reached the same research productivity, then (i) the world’s steady-state growth rate would double, and (ii) developing countries would close the gap in terms of both growth rate and income per capita. ∗Contact: anamaria.santacreu@insead.edu. I am very grateful to Jonathan Eaton for his support and guidance. I am also grateful to Diego Comin, Antonio Fatas, Mark Gertler, Denis Gromb, Boyan Jovanovic, Sam Kortum, Demian Pouzo, Kim Ruhl, and Gianluca Violante as well as to seminar participants at NYU, the Federal Reserve Bank, Wharton University of Pennsylvania, Boston College, the IMF, University of Texas, CREI, Universitat Autonoma de Barcelona, Universidad Carlos III, London Business School, University of British Columbia, Toulouse School of Economics, and INSEAD. I am responsible for any errors. Financial support by CICYT grant ECO2008-04669 is gratefully acknowledged.
Ablation of 4E-BP1/2 Prevents Hyperglycemia-Mediated Induction of VEGF Expression in the Rodent Retina and in Müller Cells in Culture

OBJECTIVE Vascular endothelial growth factor (VEGF) contributes to diabetic retinopathy, but control of its expression is not well understood. Here, we tested the hypothesis that hyperglycemia mediates induction of VEGF expression in a eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP) 1 and 2 dependent manner. RESEARCH DESIGN AND METHODS The retina was harvested from control and type 1 diabetic rats and mice and analyzed for VEGF mRNA and protein expression as well as biomarkers of translational control mechanisms. Similar analyses were performed in Müller cell cultures exposed to hyperglycemic conditions. The effect of 4E-BP1 and 4E-BP2 gene deletion on VEGF expression was examined in mice and in mouse embryo fibroblasts (MEFs). RESULTS Whereas VEGF mRNA in the retina remained constant, VEGF expression was increased as early as 2 weeks after the onset of diabetes. Increases in expression of 4E-BP1 protein mirrored those of VEGF and expression of 4E-BP1 mRNA was unchanged. Similar results were observed after 10 h of exposure of cells in culture to hyperglycemic conditions. Importantly, the diabetes-induced increase in VEGF expression was not observed in mice deficient in 4E-BP1 and 4E-BP2, nor in MEFs lacking the two proteins. CONCLUSIONS Hyperglycemia induces VEGF expression through cap-independent mRNA translation mediated by increased expression of 4E-BP1. Because the VEGF mRNA contains two internal ribosome entry sites, the increased expression is likely a consequence of ribosome loading at these sites. These findings provide new insights into potential targets for treatment of diabetic retinopathy.
Dengue-related deaths in Puerto Rico, 1992-1996: diagnosis and clinical alarm signals.

BACKGROUND Dengue, although endemic in Puerto Rico, is often not mentioned in the death certificates of decedents with laboratory results positive for dengue. Because confirmatory results are usually not available during hospitalization, we examined the utility of 2 instruments for diagnosis on the basis of clinical findings: the definition of dengue hemorrhagic fever (DHF) and the publicized (but unevaluated) clinical alarm signals for impending dengue shock. METHODS We studied data from all patients with laboratory test results positive for dengue who died (23 patients) and from the 8 patients whose death certificates listed dengue as a cause of death but whose laboratory test results were negative for dengue in Puerto Rico from 1992 through 1996. We examined hospital records to determine whether the clinical criteria for DHF were fulfilled and evaluated the incidence and timing of clinical alarm signals (intense, sustained abdominal pain; persistent vomiting; sudden change from fever to hypothermia; and marked restlessness or lethargy) and the hematocrit/hemoglobin ratio as an indicator of hemoconcentration. RESULTS A similar proportion of patients with laboratory test results positive for dengue (18 [78%] of 23) and negative for dengue (6 [75%] of 8) fulfilled the criteria for DHF. Clinical alarm signals were found only among patients with laboratory test results positive for dengue and were usually noted on the day that the patient's condition deteriorated. The hematocrit/hemoglobin ratio identified 1 (6%) of 16 patients with dengue who had significant hemoconcentration. Important comorbidities were present in 16 (70%) of the patients with laboratory test results positive for dengue and in 4 (50%) of the patients with dengue-related deaths with laboratory test results negative for dengue. CONCLUSIONS Dengue-related deaths in Puerto Rico often occur in patients with comorbidities. Among such patients, the DHF definition and the hematocrit/hemoglobin ratio were not useful in identifying patients with laboratory test results positive for dengue. In contrast, the clinical alarm signals for shock supported the dengue diagnosis and should alert clinicians to the severity of the disease.
Species richness and interacting factors control invasibility of a marine community

Anthropogenic vectors have moved marine species around the world leading to increased invasions and expanded species' ranges. The biotic resistance hypothesis of Elton (in The ecology of invasions by animals and plants, 1958) predicts that more diverse communities should have greater resistance to invasions, but experiments have been equivocal. We hypothesized that species richness interacts with other factors to determine experimental outcomes. We manipulated species richness, species composition (native and introduced) and availability of bare space in invertebrate assemblages in a marina in Monterey, CA. Increased species richness significantly interacted with both initial cover of native species and of all organisms to collectively decrease recruitment. Although native species decreased recruitment, introduced species had a similar effect, and we concluded that biotic resistance is conferred by total species richness. We suggest that contradictory conclusions in previous studies about the role of diversity in regulating invasions reflect uncontrolled variables in those experiments that modified the effect of species richness. Our results suggest that patches of low diversity and abundance may facilitate invasions, and that such patches, once colonized by non-indigenous species, can resist both native and non-indigenous species recruitment.
Evolution of inflation-generated magnetic field through phase transitions

We study the evolution of an inflation-generated magnetic field, due to its coupling to fluid motions, during cosmological phase transitions. We find that the magnetic field stays almost unchanged on large scales, while on small scales, the spectrum is modified in such a way that power at small scales becomes progressively suppressed. We also show that the magnetic field generates turbulent motions in the initially turbulence-free plasma. On large scales, the slope of the resulting kinetic energy spectrum is consistent with that of white noise.
Designing for Nomadic Play : A case study of participatory design with children

This poster presents the results from an empirical probe study trying to engage children meaningfully in the design process of systems and artifacts that support nomadic lifestyle. Based on observational studies and interviews with children of different ages (5-15 years), we conducted a participatory design workshop cycle where children were encouraged to envision and virtually play with not-yetinvented future technology. Findings include qualitative characterizations of children’s activities (e.g. ‘play’ culture, use of digital media, age and gender differences, relation to space) and methodological considerations (e.g. the role of context and structure for different age groups, workshop formats, expenditure of time).
Even intense religiosity is declining in the United States: Comment

In their 2017 article, 'The Persistent and Exceptional Intensity of American Religion: A Response to Recent Research,' Schnabel and Bock claimed that 'intense religion . is persistent and, in fact, only moderate religion is on the decline in the United States. ' In this article, we show that even the intensely religious segment of the American population is indeed shrinking. Schnabel and Bock mistakenly concluded otherwise because their analytical strategy was not sufficiently sensitive to detect very slow change (leading them to miss signs of declining intense religion on the indicators they examined), they examined a limited set of indicators (missing still more signs of declining intense religion), and they paid insufficient attention to cohort differences. Overall, their empirical conclusion that 'only moderate religion is on the decline in the United States' is simply false. And their interpretive conclusion that 'intense religion in the United States is persistent and exceptional in ways that do not fit the secularization thesis' should be rejected.