Miracle-dz/UniFAR-FTUs huggingface dataset:
Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats.

BACKGROUND AND PURPOSE The intraluminal suture middle cerebral artery occlusion (MCAO) model is increasingly used in experimental stroke studies. The purposes of this study were to determine whether (1) spontaneous hyperthermia occurs after different periods of MCAO in this model, (2) hypothalamic injury contributes to hyperthermia, and (3) hyperthermia increases infarct volume after permanent MCAO. METHODS Rats were subjected to 60, 90, and 120 minutes of transient MCAO (n=8 per group), permanent MCAO (n=8 per group, 5 groups), and permanent hypothalamic occlusion, in which an occluder was inserted 15 to 15.5 mm to block only the hypothalamic branch from the internal carotid artery (n=4) with the use of the intraluminal suture MCAO method. In one group undergoing permanent MCAO, the body temperature was maintained at 37 degrees C throughout the experiment. In another group (n=4) undergoing 90 minutes of temporary MCAO, diffusion- and perfusion-weighted imaging were performed to document the in vivo ischemic changes in the hypothalamus. Body temperature was measured hourly for 12 hours. At 24 hours (12 hours in 2 permanent MCAO groups), triphenyltetrazolium chloride staining was used to verify ischemic hypothalamic injury and to calculate corrected infarct volumes. RESULTS Spontaneous hyperthermia (>39 degrees C) occurred in the 120-minute group, all permanent MCAO groups, and the hypothalamic occlusion group but not in the 60-minute or the 90-minute groups. Hypothalamic infarction was found in 1 rat each in the 60-minute and 90-minute groups, 6 of the 8 rats in the 120-minute group, 37 of the 40 rats in the permanent occlusion groups, and all 4 rats in the hypothalamic occlusion group. After 90 minutes of transient MCAO, the decreased cerebral blood flow and apparent diffusion coefficient values in the hypothalamic region during occlusion recovered fully 2 hours after reperfusion. The corrected infarct volumes were identical in all permanent occlusion groups. CONCLUSIONS The intraluminal suture MCAO lasting for >/=2 hours induces spontaneous hyperthermia that is associated with hypothalamic injury, and delayed spontaneous hyperthermia does not increase infarct volume after permanent intraluminal suture MCAO.
Large-Scale Evolution of Image Classifiers

Neural networks have proven effective at solving difficult problems but designing their architectures can be challenging, even for image classification problems alone. Our goal is to minimize human participation, so we employ evolutionary algorithms to discover such networks automatically. Despite significant computational requirements, we show that it is now possible to evolve models with accuracies within the range of those published in the last year. Specifically, we employ simple evolutionary techniques at unprecedented scales to discover models for the CIFAR-10 and CIFAR-100 datasets, starting from trivial initial conditions and reaching accuracies of 94.6% (95.6% for ensemble) and 77.0%, respectively. To do this, we use novel and intuitive mutation operators that navigate large search spaces; we stress that no human participation is required once evolution starts and that the output is a fully-trained model. Throughout this work, we place special emphasis on the repeatability of results, the variability in the outcomes and the computational requirements.
Geographic socioeconomic status, race, and advanced-stage breast cancer in New York City.

OBJECTIVES This study examined the association between a residential area' socioeconomic status (SES), race, and advanced-stage breast cancer in New York City. METHODS The cross-sectional study design used breast cancer information for 37 921 cases diagnosed in New York City from 1986 to 1995. Residential education and income levels were based on the 1990 census and ascribed to each case by zip code. Associations between race, area SES, and advanced-stage breast cancer stage, and the interaction between race and SES, were evaluated in bivariate and multivariate analyses. RESULTS After adjusting for age and year at diagnosis, living in areas with lower levels of education and income increased the odds of presenting with advanced-stage breast cancer by 50% for Black women and by 75% for White women. No significant qualitative interaction was present between area SES and race. CONCLUSIONS This study confirmed independent racial and socioeconomic differences in the risk of advanced-stage breast cancer in a large and diverse population. The results emphasize the need to improve screening practices and clinical treatment in both high-risk populations and high-risk geographic areas.
'Fine-to-Coarse' Route Planning and Navigation in Regionalized Environments

Environments that are divided into regions lead to hierarchical encoding of space. Such memory structures are known to systematically distort estimates of distance and direction and affect spatial priming and memory recall. Here we present two navigation experiments in virtual environments that reveal an influence of environmental regions on human route planning and navigation behaviour. Following the hierarchical theories of spatial representations, it is argued that environmental regions are explicitly represented in spatial memory and that human route planning takes into account region-connectivity and is not based on place-connectivity alone. We also propose a fine-to-coarse planning heuristic that could account for the empirical data by planning in a representation that uses fine-space information for close locations and coarse-space information for distant locations simultaneously.
The Chan Hol cave near Tulum (Quintana Roo, Mexico): evidence for long‐lasting human presence during the early to middle Holocene

Numerous charcoal accumulations discovered in the submerged Chan Hol cave near Tulum, Quintana Roo, Mexico, have been 14C‐dated revealing ages between 8110 ± 28 14C a BP (9122–8999 cal a BP) and 7177 ± 27 14C a BP (8027–7951 cal a BP). These charcoal concentrations, interpreted here as ancient illumination sites, provide strong evidence that the Chan Hol cave was dry and accessible during that time interval. Humans used the cave for at least 1200 years during the early and middle Holocene, before access was successively interrupted by global sea level rise and flooding of the cave system. Our data thus narrow the gap between an early settlement in the Tulum area reaching from the late Pleistocene (∼13 000 a) to middle Holocene (e.g. 7177 14C a BP), and the Maya Formative period at approximately 3000 a bp. Yet, no evidence has been presented to date for human settlement during the ∼4000‐year interval between 7000 and 3000 a. This is remarkable as settlement in other areas of south‐eastern Mexico (e.g. Chiapas, Tabasco) and in Guatemala was apparently continuous.
Quantum information and physics: Some future directions

Abstract I consider some promising future directions for quantum information theory that could influence the development of 21st century physics. Advances in the theory of the distinguishability of superoperators may lead to new strategies for improving the precision of quantum-limited measurements. A better grasp of the properties of multi-partite quantum entanglement may lead to deeper understanding of strongly-coupled dynamics in quantum many-body systems, quantum field theory, and quantum gravity.
The Impact of Envy on Relational Employment Contracts

We study the effects of envy on relational employment contracts in a standard moral hazard setup with two agents. Performance is evaluated via an observable, but non-contractible signal which reflects an agent's individual contribution to firm value. Both agents exhibit horizontal disadvantageous inequity aversion. In contrast to the literature, we find that inequity aversion may be beneficial; in the presence of envy, for a certain range of interest rates, relational contracts may be more profitable. For some interest rates reputational equilibria exist only with envious agents.
Flexibility in Adaptation Planning : When, Where and How to Include Flexibility for Increasing Urban Flood Resilience

The magnitude and urgency of the need to adapt to climate change is such that addressing it has been taken up by the United Nations as one of the sustainable development goals - Goal 13 (SDG13) in 2015. SDG13 emphasises the need to strengthen resilience and adaptive capacity to climate related hazards and natural disasters. Coping with urban floods is one of the major needs of climate adaptation, where integration of climate change responses into flood risk management policies, strategies and planning at international, national, regional and local levels is now the norm. However, much of this integration lacks effectiveness or real commitment from stakeholders involved in adaptation planning and implementation. Hence this research has focused on integrating flexibility based adaptation responses into an urban flood risk management context. The research has synthesised flexible adaptation practices from several disciplines including information technology, automobile and aerospace manufacturing. The outcomes of the research are brought together in a framework for structuring local adaptation responses and an adaptation planning process based on flexibility concepts. The outcomes provide a way to assist with the identification of the appropriate nature and type of flexibility required; where flexibility can best be incorporated; and when is the most appropriate time to implement the flexible adaptation responses in the context of urban flooding.
Molecular Characterization of Two Types of rDNA Units in a Single Strain of Candida albicans

ABSTRACT. Strains of the opportunistic fungal pathogen Candida albicans vary in the presence or absence of a self‐splicing group I intron ribozyme (Ca.LSU) in the 25S rRNA gene on chromosome R. Strains of C. albicans typically either lack or contain this ribozyme. However, some strains have both intron‐containing and intronless rRNA genes (rDNA). Pulsed‐field gel electrophoresis analysis of undigested and restricted DNA showed at least six different karyotypes among eight independent colonies of such a heteroallelic strain. In each case, the variation was in chromosome R, and was due to changes in the number of rDNA units. In strains with only one type of rDNA, chromosome R also varied considerably. Polymerase chain reaction amplification spanning the rDNA unit demonstrated that intron‐containing rDNA units are tandemly arrayed, and are immediately adjacent to intronless units in the same cluster. Both types of units were present in the rDNA clusters of both R chromosomes. Possible explanations of these results are loss of Ca.LSU group I intron through purifying selection and/or a relaxation of the commonly accepted concerted evolution of the rDNA units.
Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

Myc plays a key role in homeostasis of the skin. We show that Miz1, which mediates Myc repression of gene expression, is expressed in the epidermal basal layer. A large percentage of genes regulated by the Myc–Miz1 complex in keratinocytes encode proteins involved in cell adhesion, and some, including the α6 and β1 integrins, are directly bound by Myc and Miz1 in vivo. Using a Myc mutant deficient in Miz1 binding (MycV394D), we show that Miz1 is required for the effects of Myc on keratinocyte responsiveness to TGF-β. Myc, but not MycV394D, decreases keratinocyte adhesion and spreading. In reconstituted epidermis, Myc induces differentiation and loss of cell polarization in a Miz1-dependent manner. In vivo, overexpression of β1 integrins restores basal layer polarity and prevents Myc-induced premature differentiation. Our data show that regulation of cell adhesion is a major function of the Myc–Miz1 complex and suggest that it may contribute to Myc-induced exit from the epidermal stem cell compartment.
Predictors of Recurrent Esophageal Food Impaction: A Case-Control Study

Background Esophageal food impaction (FI) is a distressing condition requiring urgent endoscopic intervention, with a reported recurrence rate between 10% and 20%. Knowledge of factors predisposing to recurrent FI may enable preventive measures to minimize the risk of recurrence. Objective To identify risk factors associated with recurrent FI. Design Retrospective case-control study. Setting Tertiary referral center. Patients A prospectively maintained database and medical records of all patients undergoing emergent endoscopy for FI from 1989 to 2000 were reviewed. Cases were defined as those presenting with more than 1 episode of FI, whereas controls were defined as those without recurrence within 5 years of the index episode. Several demographic, clinical, endoscopic, and follow-up variables were extracted. Statistical analysis included χ2 tests and t tests for univariate analysis, and stepwise logistic regression for multivariate analysis. Interventions NA. Main Outcome Measurements Predictors of recurrent FI. Results A total of 52 cases and 124 controls were identified (recurrence rate 30%). Presence of a diaphragmatic hernia [odds ratio (OR) 2.65; confidence interval (CI) 1.19-5.89], disimpaction by piecemeal extraction (OR 2.32; CI 1.09-4.97), and acquisition of esophageal biopsies (OR 3.69; CI 1.42-9.66) increased odds for recurrent FI. Physician follow-up after FI decreased the odds for recurrent FI (OR 0.38; CI 0.18-0.80). Limitations Retrospective study. Conclusions The presence of a diaphragmatic hernia, complexity of endoscopic disimpaction technique, and lack of follow-up increased risk for recurrent FI. Collection of esophageal biopsies as a risk factor suggests a visibly more severe esophageal disorder as a potential cause for recurrent FI.
Naive Infinitism: The Case for an Inconsistency Approach to Infinite Collections

This paper expands upon a way in which we might rationally doubt that there are multiple sizes of infinity. The argument draws its inspiration from recent work in the philosophy of truth and philosophy of set theory. More specifically, elements of contextualist theories of truth and multiverse accounts of set theory are brought together in an effort to make sense of Cantor’s troubling theorem. The resultant theory provides an alternative philosophical perspective on the transfinite, but has limited impact on everyday mathematical practice.
Predicting organismal vulnerability to climate warming: roles of behaviour, physiology and adaptation

A recently developed integrative framework proposes that the vulnerability of a species to environmental change depends on the species' exposure and sensitivity to environmental change, its resilience to perturbations and its potential to adapt to change. These vulnerability criteria require behavioural, physiological and genetic data. With this information in hand, biologists can predict organisms most at risk from environmental change. Biologists and managers can then target organisms and habitats most at risk. Unfortunately, the required data (e.g. optimal physiological temperatures) are rarely available. Here, we evaluate the reliability of potential proxies (e.g. critical temperatures) that are often available for some groups. Several proxies for ectotherms are promising, but analogous ones for endotherms are lacking. We also develop a simple graphical model of how behavioural thermoregulation, acclimation and adaptation may interact to influence vulnerability over time. After considering this model together with the proxies available for physiological sensitivity to climate change, we conclude that ectotherms sharing vulnerability traits seem concentrated in lowland tropical forests. Their vulnerability may be exacerbated by negative biotic interactions. Whether tropical forest (or other) species can adapt to warming environments is unclear, as genetic and selective data are scant. Nevertheless, the prospects for tropical forest ectotherms appear grim.
Cognitive Enhancement using Odor

Cognitive Enhancement refers to the procedure by which the abilities or capacities of a healthy brain can be improved further through improvement of processing system of brain. The dictionary meaning of enhancement says "enhancement is to raise to a higher degree". Thus enhancement can be done by using some kind of interventions like music, odor, meditation, brain wave entrainment. In this research, we use odor as an intervention. Olfaction plays a very important role in extending or amplifying the core capacities of the mind.
[Comparison of three methods of inducing chronic elevation of intraocular pressure in the pig (experimental glaucoma)].

PURPOSE To compare three methods of inducing experimental glaucoma in the adult pig, based on achieving chronic elevation of the intraocular pressure (IOP). METHODS A total of 16 adult pigs were used in the present study. In all instances, the right eye was used as control and the left eye as the experimental eye. The animals were divided into three groups: 1) 3 pigs in which 3 episcleral veins were cauterized (experimental period = 21 weeks); 2) 6 animals in which the anterior chamber of the eye was injected with a solution containing latex fluorospheres (experimental period = 11 weeks); and 3) 4 pigs in which the anterior chamber of the eye was injected with a solution containing latex fluorospheres plus methylcellulose (experimental period = 11 weeks). RESULTS The episcleral vein cauterization was the only method which produced a sustained elevation of the IOP throughout most of the experimental period. Moreover, the elevation of the IOP achieved by this method resulted in selective retinal ganglion cell (RGC) loss that affected mainly the mid-peripheral and peripheral retina and caused an increase in the mean soma area of the remaining RGCs. CONCLUSIONS Cauterization of the episcleral veins resulted in a significant and sustained elevation of the IOP and RGC loss when compared with the other two approaches tested in the present study, which barely modified the pig's RGC distribution. Thus, we conclude that the episcleral vein cauterization is the best of the methods tested to induce experimental glaucoma in the pig.
Neural mechanisms of economic commitment in the human medial prefrontal cortex

Neurobiologists have studied decisions by offering successive, independent choices between goods or gambles. However, choices often have lasting consequences, as when investing in a house or choosing a partner. Here, humans decided whether to commit (by acceptance or rejection) to prospects that provided sustained financial return. BOLD signals in the rostral medial prefrontal cortex (rmPFC) encoded stimulus value only when acceptance or rejection was deferred into the future, suggesting a role in integrating value signals over time. By contrast, the dorsal anterior cingulate cortex (dACC) encoded stimulus value only when participants rejected (or deferred accepting) a prospect. dACC BOLD signals reflected two decision biases–to defer commitments to later, and to weight potential losses more heavily than gains–that (paradoxically) maximised reward in this task. These findings offer fresh insights into the pressures that shape economic decisions, and the computation of value in the medial prefrontal cortex. DOI: http://dx.doi. org/10.7554/eLife.03701. 001
Genetic Dissection of Blackleg Resistance Loci in Rapeseed (Brassica napus L.)

Blackleg disease caused by the heterothallic ascomycete fungus Leptosphaeria maculans (Desm.) Ces. et de Not. (anamorph: Phoma lingam Tode ex Fr.), is the major disease of Brassica crops such as turnip rape (Brassica rapa L. syn. B. campestris; 2n = 2x = 20, genome AA), cabbage (B. oleracea L.; 2n = 2x = 18, genome CC), rapeseed (syn. canola or oilseed rape B. napus L.; 2n = 4x = 38, genome AACC), and B. juncea L. (Indian or brown mustard; 2n = 4x = 36, genome AABB) grown in temperate regions of the world. It was recorded for the first time on stems of red cabbage [1]. B. napus originated as a result of natural interspecific hybridization and genome doubling between the monogenomic diploid species, B. rapa and B. oleracea, in southern Europe approximately 10,000–100,000 years ago [2, 3]. However, it was selected and grown as an oilseed crop only 300-500 years ago [4, 5]. B. napus originally evolved as a spring or semi-winter type under the Mediterranean climates, and spread rapidly from southern to northern Europe after the development of winter B. napus varieties [6]. Both spring and winter types are affected by blackleg disease, particularly in Australia, Europe and North America. Currently B. napus is the world’s third most important oilseed crop, grown on an area of over 23 million hectares and produce almost 53.3 million tonnes annually [7]. Increase in B. napus production has been attributed to the development and release of high yielding superior varieties including hybrids having traits such as high oil content, improved protein quality and herbicide resistance for better crop management.
Pregnancy outcomes after laparoscopic ovarian drilling in women with polycystic ovarian syndrome.

OBJECTIVE To study whether there is an increased risk of glucose intolerance and hypertensive complications during pregnancy in women with polycystic ovarian syndrome (PCOS) who conceived after laparoscopic ovarian drilling and to investigate if there is an adverse pregnancy outcome. METHODS This prospective study took place at Salmaniya Medical Complex in Bahrain, between June 1996 and June 2003. We compared the pregnancy and neonatal outcomes of 134 patients with PCOS who were treated with laparoscopic ovarian drilling with 479 pregnant women without PCOS (controls). We used the multiple logistic regression analysis to assess the risk of PCOS on impaired glucose tolerance (IGT), gestational diabetes mellitus (GDM), hypertensive disorders in pregnancy (HDP) and premature delivery. RESULTS Subjects with PCOS had a significantly greater prepregnancy body mass index, prevalence of obesity and nulliparity as compared with controls. The incidence of IGT (p=0.007), GDM (p=0.01) and HDP (p=0.001) were significantly higher in pregnant PCOS compared with the control group. There were no significant differences in the neonatal outcomes and prevalence of premature delivery between the 2 study groups. When non-obese PCOS patients were compared with non-obese controls, the incidence of GDM (p=0.04) and HDP (p=0.004) were still significantly higher in the former. The prevalence of pregnancy complications were not significantly different when obese PCOS were compared with obese control patients. The PCOS was demonstrated as a risk factor for IGT (p=0.05), GDM (p=0.03) and HDP (p=0.03), but not for premature delivery. CONCLUSION Women with PCOS who conceived after the drilling were at higher risk of IGT, GDM and HDP, and this risk seemed to be independent of maternal obesity.
Liquefaction potential of recent fills versus natural sands located in high-seismicity regions using shear-wave velocity

AbstractThe liquefaction potential of clean and silty sands is examined on the basis of the field measurement of the shear-wave velocity, Vs. The starting point is the database of 225 case histories supporting the Andrus-Stokoe Vs-based liquefaction chart for sands, silts, and gravels. Only clean and silty sands with nonplastic fines are considered, resulting in a reduced database of 110 case histories, which are plotted separately by type of deposit. A line of constant cyclic shear strain, γcl≈0.03%, is recommended for liquefaction evaluation of recent uncompacted clean and silty sand fills and earthquake magnitude, Mw=7.5. The geologically recent natural silty sand sites in the Imperial Valley of southern California have significantly higher liquefaction resistance as a result of preshaking caused by the high seismic activity in the valley. A line of constant cyclic shear strain, γcl≈0.1–0.2%, is recommended for practical use in the Imperial Valley. Additional research including revisiting available Vs-.