Miracle-dz/UniFAR-FTUs huggingface dataset:
Komorbidität und elterliche Psychopathologie bei externalisierenden Verhaltensstörungen im Kindesalter

Zusammenfassung. In der vorliegenden Untersuchung wurde auf Grundlage von 61 Familien mit external auffalligen Kindern in einem ersten Schritt hinsichtlich der Storungsbilder Aufmerksamkeitsdefizit-/Hyperaktivitatsstorung (ADHS), Storung mit oppositionellem Trotzverhalten (OPP) sowie der Subgruppe mit beiden Storungsformen (ADHS+OPP) eine Subgruppendifferenzierung vorgenommen. Dabei erwies sich die ADHS+OPP-Subgruppe als umfangreichste Teilgruppe (50%) mit der signifikant schwersten Storungsform. Die Verhaltensprobleme der Kinder zeigten sich Subgruppen ubergreifend am haufigsten im Umgang mit den Eltern und am zweit haufigsten mit Gleichaltrigen und Geschwistern. Der Umgang mit jungeren oder alteren Kindern sowie mit fremden Personen erwies sich dem gegenuber Subgruppen ubergreifend als nahezu problemlos. Die untersuchten Eltern wiesen uber verschiedene Testskalen hinweg zu 18 bis 34% psychische Beeintrachtigungen auf. Varianzanalysen zeigten, dass die psychischen Beeintrachtigungen der Mutter und Vater .
Managing Phishing Emails: A Scenario-Based Experiment

In this paper, the authors report on a collaborative research project that investigates how people respond to phishing emails compared to genuine emails and what factors contribute to this behaviour. A scenario-based, role-play experiment was conducted by administering a web-based questionnaire via a series of seminars facilitated by a member of the research team. This questionnaire asked each of the 117 participants to evaluate 50 emails – half that were genuine and half that were phishing emails. In addition, demographic, personality and cognitive information was elicited from each participant. The major findings of this preliminary investigation indicate that personal characteristics such as familiarity with computers, extraversion, openness and cognitive impulsivity each have a significant effect on an email user’s response to phishing emails.
What Helps and What Hinders in Cross-Cultural Clinical Supervision

This study investigated what helped and what hindered in cross-cultural supervision. The participants were 25 visible minority graduate students and early counseling professionals. They were individually interviewed according to an expanded version of Flanagan’s critical incident technique. The most frequently cited positive themes were subsumed in five key areas: (a) personal attributes of the supervisor, (b) supervision competencies, (c) mentoring, (d) relationship, and (e) multicultural supervision competencies. The most frequently reported negative themes were grouped into five areas: (a) personal difficulties as a visible minority, (b) negative personal attributes of the supervisor, (c) lack of a safe and trusting relationship, (d) lack of multicultural supervision competencies, and (e) lack of supervision competencies. The results support a person-centered mentoring model of effective supervision.
Psychological adjustment to systemic sclerosis—exploring the association of disease factors, functional ability, body related attitudes and fear of negative evaluation

The psychological impact of chronic, disabling, disfiguring and painful conditions such as systemic sclerosis (SSc) may be considerable. The purpose of the study was to examine the psychological impact of SSc and to investigate the relative importance of disease parameters, functional ability and cognitive variables specifically regarding fear of negative evaluation and negative body related attitudes in relation to psychological adjustment to the condition. Forty-nine consecutive patients with SSc completed a range of standardized psychological assessments measuring anxiety, depression, attitudes towards the body, fear of negative evaluation and specific SSc-related clinical problems experienced. Over one-third of patients sampled were classified as being probable cases for anxiety or depression. Multiple regression analysis indicated that fear of negative evaluation was the most important variable accounting for 56% of the variance in anxiety, whereas overall interference of SSc on activities made the most significant contribution (F1,38 = 17.3, p < 0.001) to depression. Holistic assessment of patients with SSc including psychosocial as well as clinical assessments may be pertinent in optimizing patient management.
Modulation of muscarinic system with serotonin-norepinephrine reuptake inhibitor antidepressant attenuates depression in mice

Objective: Several studies suggest that muscarinic receptor antagonist scopolamine is a rapidly acting antidepressant for the treatment-resistant depression. Therefore, this study was carried out to investigate the possibility of synergistic potential of scopolamine with antidepressants for the treatment of depression without memory impairment in mice. Materials and Methods: Antidepressants such as citalopram, duloxetine, fluvoxamine, and venlafaxine at their median effective dose that is 12.5, 42.8, 17.5, 15.7 mg/kg p.o. , respectively, were evaluated in combination with scopolamine 0.2 mg/kg intraperitoneally for the synergistic potential for ameliorating depression in Swiss albino mice. A battery of tests including forced swim test (FST) and tail suspension test (TST) were performed in all the groups comprising vehicle control, scopolamine, antidepressants per se, and the combinations of antidepressants with scopolamine. This was followed by the locomotor activity and memory tests. Results: Behavioral studies indicated that only antidepressant venlafaxine with scopolamine resulted in 95.5% and 93.6% reduction in immobility time compared to the vehicle control in FST and TST, respectively. This is significant (P < 0.0001) synergistic hyper-additive antidepressive-like effect compared to scopolamine per se and venlafaxine per se treatment effects in antidepressant paradigms. All the data were evaluated using the one-way analysis of variance followed by individual comparisons using Tukey's post-hoc test. Control open field studies demonstrated no significant increase in general locomotion after co-administration of the compounds. Step down avoidance paradigm confirmed that scopolamine at the selected dose has no cognition deficit in any mice. Conclusions: The dose of scopolamine selected for synergistic potential has no detrimental effect on memory. The present results suggest the concoction of scopolamine with venlafaxine for enhanced synergistic antidepressive effects with the reduction of dose.
Fospropofol and Remimazolam

Monitored anesthesia care is the application of varying degrees of sedation and analgesia for a patient undergoing a diagnostic or therapeutic procedure. During this period the clinician can use a variety of sedative-hypnotic and analgesic drugs while the patient maintains spontaneous respiration for the duration of the procedure. Two widely used compounds for sedation anesthesia are propofol and midazolam. Although both are available as generic formulations and commonly used for a wide array of cases, they each have limitations with important clinical implications. The following chapter reviews 2 drugs, fospropofol and remimazolam, which have been formulated to address some of these issues and offer improvements on the parent compounds.
CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1

Melanocytes reside within the basal layer of the human epidermis, where they attach to the basement membrane and replicate at a rate proportionate to that of keratinocytes, maintaining a lifelong stable ratio. In this study, we report that coculturing melanocytes with keratinocytes up-regulated CCN3, a matricellular protein that we subsequently found to be critical for the spatial localization of melanocytes to the basement membrane. CCN3 knockdown cells were dissociated either upward to the suprabasal layers of the epidermis or downward into the dermis. The overexpression of CCN3 increased adhesion to collagen type IV, the major component of the basement membrane. As the receptor responsible for CCN3-mediated melanocyte localization, we identified discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that acts as a collagen IV adhesion receptor. DDR1 knockdown decreased melanocyte adhesion to collagen IV and shifted melanocyte localization in a manner similar to CCN3 knockdown. These results demonstrate an intricate and necessary communication between keratinocytes and melanocytes in maintaining normal epidermal homeostasis.
Text to sex: The impact of cell phones on hooking up and sexuality on campus

By centering attention on how students feel after casual sex, studies of the college social scene miss an extremely important phenomenon—namely, how hookups get started. This article argues that it is in the negotiation of contact during hookups that college students creatively navigate their sexual identity. Using a mixed methodology, this research reveals that the cell phone, as both an object of communication and consumption, is essential to the formation of self, and, as such, it provides the means by which men and women can play with gender boundaries. And yet, the male dominated fraternity system at college restricts the ability of women to realize full agency within the hookup scene.
Promoting voluntary help-seeking among doctors with mental disorders

ObjectivesTo explore if the Barcelona Integral Care Program for Doctors with mental disorders (PAIMM, in Catalan) has achieved its goal of enhancing earlier and voluntary help-seeking amongst sick doctors.Material and MethodsWe conducted a retrospective chart review of 1363 medical records of physicians admitted to the inpatient and outpatient units of the PAIMM from February 1st, 1998 until December 31st, 2011. The sample was divided into 3 time periods: 1998–2004, 2005–2007 and 2008–2011 (477, 497, and 389 cases, respectively). ResultsThe mean age at admission decreased (F = 77.57, p < 0.001) from the first period ($$\bar x = 54.18$$; SD = 10.28 years) to the last period ($$\bar x = 44.81$$; SD = 10.65 years), while voluntary referrals increased from 81.3% to 91.5% (Chi2 = 17.85, p < 0.001). Mental disorders other than substance use disorders grew from 71% during the 1998–2003 period, to 87.4% (2004–2007), and 83.9% in the last period (Chi2 = 29.01, p < 0.001). Adjustment disorders increased their prevalence, while inpatient treatment progressively represented less of the overall clinical activity.ConclusionsSick doctors may feel encouraged to seek help in non-punitive programs specially designed for them and where treatment becomes mandatory only when there is risk or evidence of malpractice.
In vitro comparative toxicology of polyquad-preserved and benzalkonium chloride-preserved travoprost/timolol fixed combination and latanoprost/timolol fixed combination.

PURPOSE To compare, in vitro, the cytotoxicity profile of a new formulation of travoprost 0.004%/timolol 0.5% fixed combination ophthalmic solution preserved with polyquaternium-1 0.001% (travoprost/timolol PQ) instead of benzalkonium chloride (BAK) with (1) commercially available travoprost 0.004%/timolol 0.5% fixed combination ophthalmic solution (travoprost/timolol BAK), (2) commercially available latanoprost 0.005%/timolol 0.5% fixed combination ophthalmic solution (latanoprost/timolol BAK), and (3) their associated BAK concentrations. METHODS Compounds tested on Wong-Kilbourne-derived human conjunctival epithelial cells: (1) phosphate-buffered saline, (2) polyquaternium-1 0.001% (Polyquad(®), PQ), (3) travoprost/timolol PQ, (4) travoprost/timolol BAK with 0.015% BAK (DuoTrav(®)), (5) BAK 0.015%, (6) latanoprost/timolol BAK with 0.020% BAK (Xalacom(®)), and (7) BAK 0.020%. Toxicological assays were used to assess cell viability [neutral red (NR), Alamar blue (AB)], apoptosis (YO-PRO-1, Hoechst 33342), and oxidative stress (H(2)DCF-DA, hydroethidine). The apoptosis and oxidative stress assays were each reported according to cell viability as observed with NR and AB (totaling 10 analyses per treatment). RESULTS The NR and AB assays demonstrated that cells incubated with travoprost/timolol PQ had significantly better viability than cells incubated with latanoprost/timolol BAK, travoprost/timolol BAK, BAK 0.015%, and BAK 0.020% (P<0.0001 for all). As assessed with YO-PRO-1 and Hoechst 33342 relative to cell viability determined with NR or AB, travoprost/timolol PQ produced significantly less apoptosis than travoprost/timolol BAK and latanoprost/timolol BAK and their respective BAK concentrations alone (P<0.0001 for all). Also, travoprost/timolol BAK induced less apoptosis than latanoprost/timolol BAK (P<0.0001). As assessed with H(2)DCF-DA as a ratio to NR or AB, all of the compounds without BAK (phosphate-buffered saline, PQ 0.001%, and travoprost/timolol PQ) and travoprost/timolol BAK produced significantly less reactive oxygen species than latanoprost/timolol BAK (P<0.0001 for all). As assessed with hydroethidine as a ratio to NR or AB, travoprost/timolol PQ produced significantly fewer superoxide anions than latanoprost/timolol BAK (P<0.0001). In contrast, release of superoxide anions (hydroethidine method) after incubation with travoprost/timolol BAK was not significantly different from incubation with latanoprost/timolol BAK or travoprost/timolol PQ. CONCLUSION Travoprost/timolol PQ may be better for ocular surface health than either BAK preserved formulations of latanoprost/timolol or travoprost/timolol.
Integral quadratic constraint theorem: A topological separation approach

This paper concerns the input/output stability of two systems in closed-loop where stability is ensured by using open-loop properties of each subsystem. The literature is divided into consideration of time-domain and frequency-domain conditions. A complete time-domain approach is given by dissipative and topological separation theory, where both conditions are given in the time-domain. On the other hand, the frequency-domain integral quadratic constraints (IQCs) framework uses only frequency-domain conditions. Between both extremes, the classical multiplier approach and the time-domain IQC framework can be seen as hybrid versions where one condition is tested in the time-domain and other condition is tested in the frequency-domain. The time-domain is more natural for nonlinear systems, and subsystems may be unbounded in time-domain analysis. However, the frequency-domain has two advantages: firstly if one block is linear, then frequency-domain analysis leads to elegant graphical and/or LMI conditions; secondly noncausal multipliers can be used. Recently the connection between frequency domain IQCs and dissipativity has been studied. Here we use graph separation results to provide a unifying framework. In particular we show how a recent factorization result establishes a straightforward link, completing an analysis suggested previously. This factorization leads to a simple and insightful dissipative condition to analyse stability of the feedback interconnection.
Clinical application of immunoreactivity of dihydropyrimidine dehydrogenase (DPD) in gastric scirrhous carcinoma treated with S-1, a new DPD inhibitory fluoropyrimidine.

BACKGROUND A highly specific antibody against recombinant human dihydropyrimidine dehydrogenase (DPD) has been developed to immunohistochemically assess DPD expression in tumors. A new oral DPD inhibitory fluoropyrimidine (DIF), S-1, is reportedly effective against gastric scirrhous carcinoma. PATIENTS AND METHODS In this study, the relationship between immunoreactivity to DPD in biopsy specimens and the effects of chemotherapy were investigated in 61 patients treated with first-line fluoropyrimidine-based chemotherapy (S-1:DIF, 5-FU:non-DIF) for gastric scirrhous carcinoma. RESULTS The response rate was significantly higher in patients with DPD-positive tumors than in those with DPD-negative tumors in the S-1 group (45.5%, 10.0%: p < 0.05), as compared to the 5-FU group (0%, 5.6%: p = 0.398). According to the median survival time, there was no significant difference between patients with DPD-positive tumors (364 days) and those with DPD-negative tumors (406 days; p = 0.626) in either the S-1 group or the 5-FU group (181 days and 256 days, respectively; p = 0.543). CONCLUSION This study indicates that S-1 may be effective even in gastric scirrhous carcinoma with a high level of DPD activity.
Relationships Between Computer Skills and Technostress: How Does This Affect Me?

The creation of computer software and hardware, telecommunications, databases, and the Internet has affected society as a whole, and particularly higher education by giving people new productivity options and changing the way they work (Hulbert, 1998). In the so-called "Information Age" the increasing use of technology has become the driving force in the way people work, learn, and play (Drake, 2000). As this force evolves, the people using technology change also (Nelson, 1990).
Face recognition implementation for client server mobile application using PCA

For the past few years in the face recognition research area are made very progressive improvements. This is because of the high level and versatile technologies in use nowadays, and high level of processors running on our machines and mobile phones. Available technologies provide mechanisms which use face recognition for security identification (user face) and authentication purposes. The aim of this paper is to present and propose client - server model and to compare it with the most recent client - server models for face recognition with a GPG infrastructure which uses security private key (symmetric encryption) with main purpose to securely transmit image (user face) over the network. Moreover in the face recognition algorithm is implemented Principle Component Analysis (PCA) algorithm for face recognition. Proposed system has been tested on the mobile phone with Android OS platform, using previous research experiences where system was initially developed for DROID emulator. The implementation of the PCA is done on the MATLAB side.
Contributions to Understanding the Neuropsychology of Alcoholism: An INS Legacy

Abstract Alcohol use disorder (AUD) has been a major cause of family, social, and personal strife for centuries, with current prevalence estimates of 14% for 12-month and 29% lifetime AUD. Neuropsychological testing of selective cognitive, sensory, and motor functions complemented with in vivo brain imaging has enabled tracking the consequences of AUD, which follows a dynamic course of development, maintenance, and recovery or relapse. Controlled studies of alcoholism reviewed herein provide evidence for disruption of selective functions involving executive, visuospatial, mnemonic, emotional, and attentional processes, response inhibition, prosody, and postural stability and brain systems supporting these functions. On a hopeful front, longitudinal study provides convincing evidence for improvement in brain structure and function following sustained sobriety. These discoveries have a strong legacy in the International Neuropsychological Society (INS), starting from its early days when assumptions regarding which brain regions were disrupted relied solely on patterns of functional sparing and impairment deduced from testing. This review is based on the symposium presentation delivered at the 2017 annual North American meeting of the INS in celebration of the 50th anniversary since its institution in 1967. In the spirit of the meeting’s theme, “Binding the Past and Present,” the lecture and this review recognized the past by focusing on early, rigorous neuropsychological studies of alcoholism and their influence on research currently conducted using imaging methods enabling hypothesis testing of brain substrates of observed functional deficits. (JINS, 2017, 23, 843–859)
Deviation from Grazing Optimum in the Grassland Habitats of Romania Within and Outside the Natura 2000 Network

Grassland habitat degradation intensified in the last century worldwide and in Europe. In Romania, substantial areas of biodiverse grassland habitats that persisted due to small-scale farming are now threatened by recent land-use intensification. However, data regarding the deviation from grazing optimum, essential for management plans encompassing both socioeconomic sustainability and environment conservation, are not yet available. To fill this gap, detailed statistics of the stocking rate and its deviation from optimum were generated by spatial modeling techniques. A toolbox was developed to assess such deviations inside or outside the Natura 2000 Network of protected areas. The analysis covered an area of 33529.42 km 2 , corresponding to all the Romanian permanent grasslands within the land parcel identification system. The results indicate that over half of this area is degraded, mostly from overgrazing. Less than 10% is not impacted by inadequate livestock density. Of the national grassland area, 17.34% is included within the Natura 2000 protected sites, indicating the substantial overlapping of agricultural and protection activities. For this category, the degraded area is slightly lower than at the national level (50.34% vs. 52.45%). These results can be applied for environmental conflict anticipation and optimal management of grassland habitats to achieve both socioeconomic and conservation objectives.
Alzheimer’s Disease: Mechanism and Approach to Cell Therapy

Alzheimer’s disease (AD) is the most common form of dementia. The risk of AD increases with age. Although two of the main pathological features of AD, amyloid plaques and neurofibrillary tangles, were already recognized by Alois Alzheimer at the beginning of the 20th century, the pathogenesis of the disease remains unsettled. Therapeutic approaches targeting plaques or tangles have not yet resulted in satisfactory improvements in AD treatment. This may, in part, be due to early-onset and late-onset AD pathogenesis being underpinned by different mechanisms. Most animal models of AD are generated from gene mutations involved in early onset familial AD, accounting for only 1% of all cases, which may consequently complicate our understanding of AD mechanisms. In this article, the authors discuss the pathogenesis of AD according to the two main neuropathologies, including senescence-related mechanisms and possible treatments using stem cells, namely mesenchymal and neural stem cells.