Miracle-dz/UniFAR-FTUs huggingface dataset:
Very Low Mass Stars and Brown Dwarfs in Taurus-Auriga

We present high-resolution optical spectra obtained with the HIRES spectrograph on the W. M. Keck I Telescope of seven low-mass T Tauri stars (LMTTs) and brown dwarfs in Taurus-Auriga. The observed Li I 6708 Å absorption, low surface gravity signatures, and radial velocities confirm that all are members of the Taurus star-forming region; no new spectroscopic binaries are identified. Four of the seven targets observed appear to be T Tauri brown dwarfs. Of particular interest is the previously classified "continuum T Tauri star" GM Tau, which has a spectral type of M6.5 and possibly a substellar mass. These spectra, in combination with previous high-resolution spectra of LMTTs, are used to understand the formation and early evolution of objects in Taurus-Auriga with masses near and below the stellar/substellar boundary. None of the LMTTs in Taurus are rapidly rotating (v sin i < 30 km s-1), unlike low-mass objects in Orion. Many of the slowly rotating, nonaccreting stars and brown dwarfs exhibit prominent Hα emission (equivalent widths of 3-36 Å), indicative of active chromospheres. We demonstrate empirically that the full width at 10% of the Hα emission profile peak is a more practical and possibly more accurate indicator of accretion than either the equivalent width of Hα or optical veiling: 10% widths > 270 km s-1 are classical T Tauri stars (i.e., accreting), independent of stellar spectral type. Although LMTTs can have accretion rates comparable to that of more typical, higher mass T Tauri stars (e.g., K7-M0 spectral types), the average mass accretion rate appears to decrease with decreasing mass. A functional form of Ṁ ∝ M is consistent with the available data, but the dependence is difficult to establish because of both selection biases in observed samples and the decreasing frequency of active accretion disks at low masses (M < 0.2 M☉). The diminished frequency of accretion disks for LMTTs, in conjunction with their lower, on average, mass accretion rates, implies that they are formed with less massive disks than higher mass T Tauri stars. The radial velocities, circumstellar properties, and known binaries do not support the suggestion that many of the lowest mass members of Taurus have been ejected from higher stellar density regions within the cloud. Instead, LMTTs appear to have formed and are evolving in the same way as higher mass T Tauri stars, but with smaller disks and shorter disk lifetimes.
Altmetric: enriching scholarly content with article‐level discussion and metrics

Scholarly content is increasingly being discussed, shared, and bookmarked online by researchers. Altmetric is a start‐up that focuses on tracking, collecting, and measuring this activity on behalf of publishers; here we describe our approach and general philosophy. Over the past year we have seen sharing and discussion activity around approximately 750,000 articles. The average number of articles shared each day grows by 5–10% a month. We look at examples of how people are interacting with papers online and at how publishers can collect and present the resulting data to deliver real value to their authors and readers.
Advances in clinical trials for movement disorders

In the past several years, there have been several innovations in the design of clinical trials assessing new therapies for patients with movement disorders. These include attempts to address difficulties in conducting clinical trials in treated patients in the advanced stages of their illness, demonstrating disease‐modifying effects or a reduction in the development of cumulative disability, and assessing the effects of interventions in patients in the premanifest state of their disease. In addition, there have been advances in clinical trial methodologies and changes in regulatory guidelines that permit the performance of more efficient studies, with a reduction in the cost and duration of the development period. These will be reviewed in the present article. © 2015 International Parkinson and Movement Disorder Society
Introducing TreeClimber, a Test To Compare Microbial Community Structures

ABSTRACT The phylogenetic and ecological complexity of microbial communities necessitates the development of new methods to determine whether two or more communities have the same structure even though it is not possible to sample the communities exhaustively. To address this need, we adapted a method used in population genetics, the parsimony test, to determine the relatedness of communities. Here we describe our implementation of the parsimony test, TreeClimber, in which we reanalyzed six previously published studies and compared the results of the analysis to those obtained using ∫-LIBSHUFF.
Interactive robots for communication-care: a case-study in autism therapy

The paper proposes possible use of interactive robots in the remedial practice for children with autism, who have difficulties mainly in interpersonal communication. For this purpose, we built a small creature-like robot, Keepon, which was carefully designed to get autistic and non-autistic children involved in playful interaction. We observed how autistic children (2-4 years old) interacted with Keepon without any experimental setting or instructions in a playroom at a day-care center for children with special needs. From the longitudinal observation for a year and a half (totally, over 500 child-sessions), we found that Keepon's simple appearance and predictable responses gave the autistic children a playful and relaxed mood, in which they spontaneously engaged in dyadic play with Keepon, which would then expand into interpersonal communication where Keepon worked as the pivot of triadic play with adults or other children. Each child showed a different style and a different unfolding of interaction over time, which tell us a "story" of his or her personality and developmental profile, which would not be explained thoroughly by a diagnostic label like "autism".
Squarer exploration for energy-efficient sum of squared differences

The main reason for the long time and high energy requirements of state-of-the-art Video Coding (VC) standards, such as the HEVC, is the large amount of distortion calculations. Among the most known and used ones is the Sum of Squared Differences (SSD) which has a strong correlation with the Peak Signal-to-Noise Ratio (PSNR). Such correlation is explored by current encoders to provide a good trade-off between rate and distortion. Once VC is mandatory in current battery-powered devices, the adopted distortion metric must be as energy-efficient as possible. Although simple, the SSD requires a square operation, which hardware realization is costly. Thus, some VC hardware designs replace the SSD by the Sum of Absolute Differences (SAD). However, using SAD instead of SSD pays a price in coding efficiency. In this work we investigate four hardware designs for the square operation. Synthesis results for the designed architectures are compared to a reference SAD design from the literature. The best SSD architecture, using clock gating, requires only 20% more energy than SAD.
An Expert-System Paradigm for Design

level designer can become the detailed functional specification needed by a lower level. Within a design abstraction there are usually several possible alternative structures for a particular desired behavior. Each of these may exhibit differing cost performance characteristics and require different refinement and optimization techniques. These structures can be grouped into sets of similar characteristics called desrgn styles. Styles reflect varlous design approaches forced by different design constraints to achieve the same behavlor. A simple example Is the choice of ripple-carry addition versus carry-look-ahead. The ripple-carry adder is appropriate if space is at a higher premium than delay time. As each level is designed, constraints are produced which must be propagated to the designers at the lower levels. These constraints reflect design style declslons, or structural partitions of higher-level design constraints. Style decisions constrain the design styles and strategies of sub-section designers. An example is the decision to use pre-charged carry addition, forcing the use of appropriate implementation components. Structural partitioning refers to the dlvlding of global constraints such as time, power, or area into local constraints on these values. A requirement of 175nS as maximum cycle time makes demands on the critical path of operations in each cycle. As the design is implemented, this puts a partitioning constraint on the design of each functional component. Figure 1 shows the possible allocation of timing constraints in two stages of the design process. In the first case the allocation has simply divided the cycle time among the function units. In the second case (later in the design) a failure report from the multiply design task has forced a different allocation of time between the functional units. Iterative refinement of a design requires continuous performance monitoring relative to the design goals. This model assumes a simple approach similar to ‘Knobs’ and ‘Gauges’. A human operator monitoring a process closes the loop manually by reading the appropriate gauges and making adjustments to the knobs (parameters) controlling the process execution. We apply this same simple approach to controlling the design pro-
Protective Action of Phenytoin in Cerebral Ischemia

Thirty-six rabbits were subjected to 15-minute periods of stagnant cerebral hypoxia while blood flow to the rest of the body was preserved. After this ischemic interval the animals, divided into thee groups, received either saline, phenytoin, 15 μg/kg IV, or thiopental 10 μg/kg IV and 10 μg/kg IM. Histologic examination of tissue sections of the brains, 72 hours after ischemia, indicated that phenytoin afforded significant protection (p < 0.001) of neurons in the hippocampus and in the dentate nucleus when compared to saline, while the findings noted after thiopental were not statistically significant when compared to placebo. No statistically significant difference was noted between the two drugs. Neuron destruction was seen only in rabbits receiving either saline (92%) or thiopental (50%).
Effect of Withania somnifera Extracts on Some Selective Biochemical, Hematological, and Immunological Parameters in Guinea Pigs Experimental Infected with E. coli

Fifty 1-2-month-old Guinea pigs were divided into 5 equal groups, 10 each. Control (Gp1) did receive neither viable bacteria nor treatment. Each animal from the other groups (Gp2–5) was challenged with (1-2 × 108) viable E. coli in 200 μL normal saline (0.9%) through IP route. GP2 infected group was treated with 200 μL saline IP and kept as positive control group. Gp3-4 are infected and treated with Withania somnifera (ethanol root extract) with doses 50 and 100 mg/kg. BW, respectively. Gp5 infected treated group was treated with cefoperazone antibiotic at dose 35 mg/Kg BW. The treatment by drug or the extracted medicinal plant was started 72 h after infection for 7 successive days. Serum and whole blood sample were collected from all groups 14 days after treatment to evaluate some hematological and biochemical changes as well as immunomodulatory cytokine tumor necrosis factor-alpha (TNF-α). Oral treatment of the plant extract caused significant benefit results in infected Guinea pig appeared in the correction of some hematological and biochemical parameters also try to suppressed inflammatory cytokine response represent in TNF-α. It could be concluded that W. somnifera extract has potent antibacterial activity, and this appears in the correction with hematological, biochemical, and immunological results.
Systematic prevention of overweight and obesity in adults: a qualitative and quantitative literature analysis

To date, most interventions aimed at preventing obesity have underemphasized the application of systematic intervention development, implementation and evaluation. The present review provides a thorough insight in factors promoting implementation and/or effectiveness in interventions aimed at preventing overweight/obesity among adults. A total of 46 studies evaluating interventions aimed at preventing obesity were reviewed, followed by both qualitative and quantitative analyses. The Intervention Mapping protocol and the Environmental Research framework for weight Gain prevention (EnRG) were applied to analyse and classify the included studies. The interventions were categorized by setting (workplace, community, health care) and target group (ethnic minorities, pregnant women, [pre]menopausal women, smokers, people with intellectual disabilities). Generally, interventions were found to have potential in changing energy balance‐related behaviours and anthropometric outcomes. Effect sizes for changes in body mass index ranged between −0.09 and 0.45. When the programme goal specifically aimed at weight management, the intervention was found to be more successful than interventions with programme goals that were aimed at preventing cardiovascular disease or improving general health status. Although a considerable part of studies included motivational interventions, only some actually assessed the effects on potential cognitive mediators. A general lack of reporting underlying theoretical models for behaviour change was observed as well as the inclusion of linkage groups and strategies to promote empowerment.
Prevalence of protein-energy malnutrition at diagnosis in children with acute lymphoblastic leukemia.

BACKGROUND The purpose of the present study was to test the hypothesis that protein-energy undernutrition is common in patients with acute lymphoblastic leukemia at diagnosis. Previous studies have failed to establish whether undernutrition is a common feature at diagnosis. METHODS Body mass index (BMI, weight/height2), expressed as a standard deviation score (SDS) relative to contemporary United Kingdom reference data, was used as the index of nutritional status. The index was calculated in a national cohort of standard-risk patients (n = 1019) treated in the same protocol in the United Kingdom. RESULTS Prevalence of undernutrition (defined as BMI SDS <-2.0) exceeded expected frequencies in boys (7.6%) and girls (6.7%). These differences were statistically significant (p < 0.001), with a 95% confidence interval for the prevalence of undernutrition of 5.8% to 9.0%. CONCLUSIONS Undernutrition is relatively common in patients with newly diagnosed acute lymphoblastic leukemia, with a threefold excess of patients below the cutoff used to define undernutrition. Screening for undernutrition at diagnosis of acute lymphoblastic leukemia is indicated, and the BMI SDS is a simple index of nutritional status that could be readily calculated using measurements routinely made at diagnosis. The same simple screening technique could also be used clinically to detect and manage or prevent overnutrition (obesity), which is common in these patients after diagnosis.
Improving firearm storage habits: impact of brief office counseling by family physicians.

BACKGROUND Firearm injury is the leading cause of injury-related death among youth and second leading cause of injury-related death overall in the United States. Our objective is to determine the impact of brief office counseling by family physicians on patients' firearm storage habits. METHODS Of the 1,233 patients who completed the enrollment questionnaire, 156 (13%) reported they had guns in their household and agreed to participate in the study. Postintervention survey instruments were completed by 127 (81%) of participants. Participants received either no counseling, verbal counseling alone, or counseling and a gun safety brochure from their physician. Firearm storage habits were measured at baseline and 60 to 90 days after intervention. RESULTS At the postintervention interview, 64% of the group receiving verbal counseling and 58% of the group receiving verbal counseling plus written information made a safe change in gun storage compared with 33% of participants in the no-intervention group (P =. 02). A logistic regression model controlling for demographics and gun ownership showed that compared with the no-intervention group, intervention participants were three times more likely to make safe changes. CONCLUSIONS Family physicians' brief counseling efforts made a significant positive impact in the firearm storage habits of their patients. With a verbal or written recommendation, a significant improvement was observed in firearm storage.
Protist community composition during early phytoplankton blooms in the naturally iron-fertilized Kerguelen area (Southern Ocean)

Microbial eukaryotic community composition was examined by 18S rRNA gene tag pyrosequencing, during the early phase of spring phytoplankton blooms induced by natural iron fertilization, off Kerguelen Island in the Southern Ocean (KEOPS2 cruise). A total of 999 operational taxonomical units (OTUs), affiliated to 30 known high-level taxonomic groups, were retrieved from 16 samples collected in the upper 300 m water column. The alveolata group was the most abundant in terms of sequence number and diversity (696 OTUs). The majority of alveolata sequences were affiliated to Dinophyceae and to two major groups of marine alveolates (MALV-I and MALV-II). In the upper 180 m, only 13% of the OTUs were shared between of the fertilized stations and the reference site characterized by high-nutrient low-chlorophyll (HNLC) waters. Fungi and Cercozoa were present in iron-fertilized waters, but almost absent in the HNLC samples, while Haptophyta and Chlorophyta characterized the HNLC sample. Finally, the 300 m depth samples of all stations were differentiated by the presence of MALV-II and Radiolaria. Multivariate analysis, examining the level of similarity between different samples, showed that protistan assemblages differed significantly between the HNLC and iron-fertilized stations, but also between the diverse iron-fertilized blooms.
Driving under the influence of alcohol and drugs in the eastern part of Denmark in 2015 and 2016: Abuse patterns and trends

ABSTRACT Objectives: The objective of this study was to examine the frequency of psychoactive drugs and alcohol in drivers under suspicion of driving under the influence of drugs and alcohol in 2015 and 2016 in the eastern part of Denmark. The trends in the number of traffic cases sent for drug analysis since 2000 and alcohol analysis since 2011 are also discussed. Methods: Blood samples from drivers suspected of being under the influence of alcohol and/or medication and/or illicit drugs in 2015 and 2016 were investigated as requested by the police. The blood samples were screened for alcohol and/or tetrahydrocannabinol (THC) alone, for other drugs (covering all drugs, except THC, listed in the Danish list of narcotic drugs), or for THC and other drugs. Age and gender were also recorded. The number of drug traffic cases since 2000 and the number of alcohol cases since 2011 were extracted from our Laboratory Information Management System (LIMS). Results: In total, 11,493 traffic cases were investigated. Alcohol and/or drugs exceeded the legal limit in 9,657 (84%) cases. Men constituted 95% of the drivers investigated for drugs and 88% of the alcohol cases. The drivers investigated for drugs consisted primarily of young men, whereas drivers investigated for alcohol were older. The frequency was higher for positive alcohol cases above the legal limit (87%) than for drug cases (76%) above the fixed concentration limit. THC (67–69%) was the most frequently detected drug above the legal limit, followed by cocaine (27–28.5%), amphetamine (17%), and clonazepam (6–7%) in both years. Morphine (5.4%), included among the 5 most frequent drugs in 2015, was replaced by methadone (4.6%) in 2016. Few new psychoactive drugs (NPS) were detected. The number of traffic cases sent for drug analysis has increased more than 30-fold since 2000–2006, and the number of traffic cases submitted in 2016 for drug analysis was higher than the number for alcohol analysis; the latter has decreased since 2011. Conclusion: Overall, alcohol was the most frequent compound detected above the legal limit in both years, followed by the well-known illicit drugs THC, cocaine, and amphetamine. NPS were seldom seen. One consequence of the increased focus on drugs in traffic has been an immense increase in drug traffic cases sent for analysis since 2006 in the eastern part of Denmark. Although this survey revealed only minimal changes compared to earlier investigations, surveys like this are invaluable for monitoring abuse patterns and trends in drugged and drunken driving.
Psychometric evaluation of self-report measures of binge-eating symptoms and related psychopathology: A systematic review of the literature.

OBJECTIVE Binge eating is a symptom common to bulimia nervosa, anorexia nervosa (binge/purge subtype), and binge eating disorder. There are many self-report measures available to aid the assessment of eating disorders symptoms, but there has not yet been a systematic review of the literature to identify the most valid and reliable measures for use in assessment and treatment of binge eating. METHOD A systematic review of the psychometric properties of self-report measures that assess binge eating symptoms and psychopathology was conducted. Two independent raters assessed the psychometric properties of each measure using a standardized quality analysis tool. RESULTS Of the 2,927 studies identified, 72 studies met the inclusion criteria and described the psychometric properties of 29 different self-report measures, and nine specific subscales within these. Results from the quality analysis tool utilized in this study indicated that none of the included measures currently meet all nine criteria of adequate psychometric properties. DISCUSSION Most of the included measures had evidence for some adequate psychometric properties. Two measures received six out of nine positive ratings for the assessed psychometric properties, the BITE and the BULIT-R, and thus appear to be the measures with the most evidence of their validity and reliability. Overall, our findings implicate a need for further investigation of the psychometric properties of the available self-report questionnaires in this field.
Adhesion molecules in cerebrovascular diseases. Evidence for an inflammatory endothelial activation in cerebral large- and small-vessel disease.

BACKGROUND AND PURPOSE Adhesion molecules mediate attachment and transendothelial migration of leukocytes as a critical step in pathogenesis of atherosclerosis. Their expression and release were comparatively investigated in patients with large- and small-vessel disease of the central nervous system. METHODS With immunological methods, serum concentrations of endothelial-derived adhesion molecules (soluble endothelial-leukocyte adhesion molecule [sE-selectin], soluble vascular-leukocyte adhesion molecule-1, and soluble intercellular adhesion molecule-1 [sICAM-1]) were quantified in patients with obstructive disease of extracranial (n=89) and intracranial (n=20) large-vessel disease and patients with subcortical vascular encephalopathy (n=64), a cerebral small-vessel disease. As controls, age- and sex-matched subjects without obstructive cerebrovascular disease (n=67) were studied. RESULTS We observed significantly increased serum concentrations of sE-selectin and sICAM-1 in patients with both obstructive disease of the large brain-supplying arteries and subcortical vascular encephalopathy. Interestingly, the highest levels were observed in intracranial macroangiopathy. Furthermore, concentrations of sICAM-1 and sE-selectin were significantly increased in current smokers but not in diabetic or hypertensive patients. CONCLUSIONS The observation of elevated release of endothelial-derived adhesion molecules in both patients with stenoses of the large brain-supplying arteries and patients with subcortical vascular encephalopathy indicates that inflammatory endothelial activation and adhesion of leukocytes play similarly important roles in cerebral large- and small-vessel disease.