Miracle-dz/UniFAR-FTUs huggingface dataset:
Anomalous Structural Variations in III-Nitride Nanowire Heterostructures and Their Corresponding Optical Properties

Ternary InGaN and AlGaN alloys have been sought after for the application of various optoelectronic devices spanning a large spectral range between the deep ultraviolet and infrared, including light-emitting diodes, and laser diodes. Their non-ideal alloy mixing, and differences in bond energy and in adatom diffusion are established as the cause for various types of nanoscale compositional inhomogeneity commonly observed in nitride thin films. Growth in a nanowire geometry can overcome the phase separation, surface segregation, and chemical ordering by providing enhanced strain relaxation of the large lattice mismatch at the free surfaces. In this dissertation, the spectral and spatial luminescence distributions of ternary III-N alloy nanowire heterostructures are investigated and correlated to structural and chemical properties with scanning transmission electron microscopy. Quantitative elemental mapping of InGaN/GaN dot-in-a-wire structures using electron energy-loss spectroscopy revealed compositional non-uniformity between successive quantum dots. Local strain mapping of the heterostructure showed a dependence of the incorporation of indium on the magnitude of the out-of-plane compressive strain within the underlying GaN barrier layer. Cathodoluminescence spectroscopy on individual nanowires presented diverse emission properties, nevertheless, the In-content variability could be directly correlated to the broad range of peak emission energies. Atomic-level chemical ordering within the InGaN was then reported, and attributed to the faceted growth surface in nanowires that promotes preferential site incorporation by In-atoms that allows for better strain relaxation. Distinct atomic-scale alloy inhomogeneities were also investigated in AlGaN nanowires, which evidenced spatial localization of carriers taking place at the resulting energy band fluctuations. A high spectral density of narrow emission lines arose from such compositional modulations, whose luminescence behaviours exhibit a dependence on the nature of the compositional fluctuations from which they originate.
Green New Product Development: The Pivotal Role of Product Greenness

This study aims to develop an integrative framework for green new product development (NPD) based on the existing literature and to empirically study the applicability of that integrative framework. This study answers three calls: for research that is rooted in a traditional NPD perspective, for research that integrates marketing aspects in a model of green NPD, and for research that acknowledges variations in greenness. The results from eight case studies in two industries (i.e., the chemical and food industries) substantiate the integrative framework and suggest that it provides a good basis for understanding green NPD. The study demonstrates that green NPD is not fundamentally different from traditional NPD but does contain features and underlying mechanisms that reflect the increased complexity of green NPD. The framework incorporates the targeting and positioning of green product innovations, thus establishing itself as a holistic framework. Most importantly, the study shows how greenness plays a pivotal role in tying the various elements of the framework together. The realized greenness of a new product is a central concept that helps managers understand complex relationships among industry type, green targeting, and green positioning.
The Influence of Perenniality and Seed Banks on Polymorphism in Plant‐Parasite Interactions

Antagonistic interactions, such as diseases, play an important role in natural populations. Understanding the mechanisms that promote long‐term polymorphism at loci that are involved in host‐parasite recognition is a fundamental problem in evolutionary ecology. Coevolution implies the existence of indirect frequency‐dependent selection because the fitnesses of parasite genotypes depend on the frequencies of host genes and vice versa. Polymorphism can be maintained in both organisms if there is also negative, direct, frequency‐dependent selection, when natural selection for host resistance or parasite virulence declines with increasing frequency of that trait itself. In this article, using the gene‐for‐gene relationship as a model, we show that two plant life‐history traits, seed banks and perenniality with parasite density‐dependent disease transmission, generate frequency‐dependent selection on host resistance and are thus capable of stabilizing frequencies of coevolving host and parasite genes. The host population’s response to selection by the parasite is modified by the contribution of past selective events stored in long‐lived seed banks or in a growing population of perennial plants that have a long life span in the absence of disease. While fitness costs determine whether coevolutionary cycles occur in interacting host and parasite populations, the ecology of the two organisms determines whether stable polymorphism is maintained.
Site of Carotid Plaque Ulceration in Relation to Direction of Blood Flow: An Angiographic and Pathological Study

Background: Rupture of atherosclerotic plaque is the main cause of acute coronary syndromes and carotid territory ischaemic stroke. Haemodynamic stress is important in early plaque formation and may affect the stability of mature plaques. There is some evidence that macrophage infiltration and plaque rupture tend to localise to the proximal (upstream) part of the plaque where shear stress is highest. However, previous studies have been too small to assess this reliably. We studied the site of ulceration in a large number of carotid plaques. Methods: We studied angiograms of 3,007 symptomatic carotid stenoses, and the pathological appearance of 119 carotid plaques (77 asymptomatic), to identify the presence and position of plaque ulceration. Results: Angiographic ulceration, which was present in 421 patients (14%), was more likely to be proximal than distal to the point of maximum stenosis (OR = 16.6, 95% CI = 11.6–26.9, p < 0.001). This trend increased with severity of stenosis (p = 0.002). Pathological examination of the 119 carotid plaques also showed that ulceration was more likely to occur proximal to the point of maximum stenosis (OR = 6.1, 95% CI = 2.8–13.6, p < 0.001). Conclusions: Ulceration of carotid plaques, visible on angiography or on pathological examination, is seen most often in the proximal (upstream) part where shear stress is highest.
The Global Impact of Clouds on the Production of MODIS Bidirectional Reflectance Model-Based Composites for Terrestrial Monitoring

A global data set of cloud occurrence probability derived from Moderate Resolution Imaging Spectroradiometer (MODIS) Terra and Aqua gridded daily data is analyzed to investigate the probability of obtaining at least a minimum number of cloud-free observations within various compositing periods. The probabilities derived from Terra and Aqua, with morning and afternoon overpass times, respectively, are similar and increase with compositing period. Compositing both Terra and Aqua observations results in considerably higher probabilities of obtaining a sufficient number of observations for bidirectional reflectance model-based compositing. Given that the only alternative to obtaining sufficient samples is to extend the observation period, which can cause significant problems when the surface state changes, it is concluded that using data from the two MODIS sensors provides the most effective way of generating composited products. Findings with respect to the availability of cloud-free composites when n-day composites are generated on a temporally overlapping daily rolling basis, i.e., every day, rather than every n-days, are also discussed for regional and global applications
An algorithm for transform coding for lossy packet networks

We propose an algorithm to compute a modification of the classical discrete Karhunen-Loeve transform (KLT) useful when some of the coefficients are randomly unavailable for reconstruction. Such a scheme can provide multiple description coding (MDC) for signals and images transported by lossy packet links. The modification of the KLT is based on a "correlating" block that, from knowledge of the channel erasure statistics, is optimized with a gradient algorithm to provide minimum average reconstruction error. A set of simulations show appreciable improvements over standard schemes.
An Immunohistochemical Algorithm for Ovarian Carcinoma Typing

There are 5 major histotypes of ovarian carcinomas. Diagnostic typing criteria have evolved over time, and past cohorts may be misclassified by current standards. Our objective was to reclassify the recently assembled Canadian Ovarian Experimental Unified Resource and the Alberta Ovarian Tumor Type cohorts using immunohistochemical (IHC) biomarkers and to develop an IHC algorithm for ovarian carcinoma histotyping. A total of 1626 ovarian carcinoma samples from the Canadian Ovarian Experimental Unified Resource and the Alberta Ovarian Tumor Type were subjected to a reclassification by comparing the original with the predicted histotype. Histotype prediction was derived from a nominal logistic regression modeling using a previously reclassified cohort (N=784) with the binary input of 8 IHC markers. Cases with discordant original or predicted histotypes were subjected to arbitration. After reclassification, 1762 cases from all cohorts were subjected to prediction models (&khgr;2 Automatic Interaction Detection, recursive partitioning, and nominal logistic regression) with a variable IHC marker input. The histologic type was confirmed in 1521/1626 (93.5%) cases of the Canadian Ovarian Experimental Unified Resource and the Alberta Ovarian Tumor Type cohorts. The highest misclassification occurred in the endometrioid type, where most of the changes involved reclassification from endometrioid to high-grade serous carcinoma, which was additionally supported by mutational data and outcome. Using the reclassified histotype as the endpoint, a 4-marker prediction model correctly classified 88%, a 6-marker 91%, and an 8-marker 93% of the 1762 cases. This study provides statistically validated, inexpensive IHC algorithms, which have versatile applications in research, clinical practice, and clinical trials.
Controllability of nonlinear discrete systems

In the present paper local constrained controllability problems for nonlinear finite-dimensional discrete system with constant coefficients are formulated and discussed. Using some mapping theorems taken from functional analysis and linear approximation methods sufficient conditions for constrained controllability are derived and proved. The present paper extends the controllability conditions with unconstrained controls given in the literature to cover the nonlinear discrete systems with constrained controls.
Crystals for Demazure Modules of Classical Affine Lie Algebras

Abstract We study, in the path realization, crystals for Demazure modules of affine Lie algebras of types A (1) n , B (1) n , C (1) n , D (1) n , A (2) 2 n − 1 , A (2) 2 n , and D (2) n + 1 . We find a special sequence of affine Weyl group elements for the selected perfect crystal, and show that if the highest weight is l Λ 0 , the Demazure crystal has a remarkably simple structure.
GeneCards: a novel functional genomics compendium with automated data mining and query reformulation support

MOTIVATION Modern biology is shifting from the 'one gene one postdoc' approach to genomic analyses that include the simultaneous monitoring of thousands of genes. The importance of efficient access to concise and integrated biomedical information to support data analysis and decision making is therefore increasing rapidly, in both academic and industrial research. However, knowledge discovery in the widely scattered resources relevant for biomedical research is often a cumbersome and non-trivial task, one that requires a significant amount of training and effort. RESULTS To develop a model for a new type of topic-specific overview resource that provides efficient access to distributed information, we designed a database called 'GeneCards'. It is a freely accessible Web resource that offers one hypertext 'card' for each of the more than 7000 human genes that currently have an approved gene symbol published by the HUGO/GDB nomenclature committee. The presented information aims at giving immediate insight into current knowledge about the respective gene, including a focus on its functions in health and disease. It is compiled by Perl scripts that automatically extract relevant information from several databases, including SWISS-PROT, OMIM, Genatlas and GDB. Analyses of the interactions of users with the Web interface of GeneCards triggered development of easy-to-scan displays optimized for human browsing. Also, we developed algorithms that offer 'ready-to-click' query reformulation support, to facilitate information retrieval and exploration. Many of the long-term users turn to GeneCards to quickly access information about the function of very large sets of genes, for example in the realm of large-scale expression studies using 'DNA chip' technology or two-dimensional protein electrophoresis. AVAILABILITY Freely available at http://bioinformatics.weizmann. ac.il/cards/ CONTACT cards@bioinformatics.weizmann. ac.il
Middle interhemispheric variant of holoprosencephaly

Background: The middle interhemispheric variant (MIH) is a subtype of holoprosencephaly (HPE) in which the posterior frontal and parietal areas lack midline separation, whereas more polar areas of the cerebrum are fully cleaved. While the neuroradiologic features of this subtype have been recently detailed, the clinical features are largely unknown. Objective: To present the clinical manifestations of MIH and to compare them with classic subtypes (alobar, semilobar, and lobar) of HPE. Methods: The authors evaluated 15 patients with MIH in a multicenter study. Neuroimaging and clinical data were collected and correlated. They compared the data with those of 68 patients who had classic HPE. Results: The frequency of endocrinopathy in MIH (0%) was lower compared with the classic subtypes (72%) (p < 0.0001). This correlated with the lack of hypothalamic abnormalities. The percentage of patients with seizures (40%) did not significantly differ from classic HPE. Spasticity was the most common motor abnormality, seen in 86% of MIH patients, similar to other subtypes. The frequency of choreoathetosis in MIH (0%) was lower than that for semilobar HPE (41%) (p < 0.0039). This correlated with the lack of caudate and lentiform nuclei abnormalities. Developmental functions, including mobility, upper-extremity function, and language, of the MIH group were similar to the least severe classic type, lobar HPE. Conclusion: MIH is a recognizable variant of HPE with differing clinical prognosis. Similar to the lobar subtype by functional measures, MIH differs from classic HPE by the absence of endocrine dysfunction and choreoathetosis.
An Energy-Efficient Underground Localization System Based on Heterogeneous Wireless Networks

A precision positioning system with energy efficiency is of great necessity for guaranteeing personnel safety in underground mines. The location information of the miners' should be transmitted to the control center timely and reliably; therefore, a heterogeneous network with the backbone based on high speed Industrial Ethernet is deployed. Since the mobile wireless nodes are working in an irregular tunnel, a specific wireless propagation model cannot fit all situations. In this paper, an underground localization system is designed to enable the adaptation to kinds of harsh tunnel environments, but also to reduce the energy consumption and thus prolong the lifetime of the network. Three key techniques are developed and implemented to improve the system performance, including a step counting algorithm with accelerometers, a power control algorithm and an adaptive packets scheduling scheme. The simulation study and experimental results show the effectiveness of the proposed algorithms and the implementation.
Predictors of continuation with olanzapine during the 1-year naturalistic treatment of patients with schizophrenia in Japan

Purpose Treatment continuation is considered an important measure of antipsychotic effectiveness in schizophrenia, reflecting the medication’s efficacy, safety, and tolerability from both patients’ and clinicians’ perspectives. This study identified characteristics of patients with schizophrenia who continue olanzapine therapy for a 1-year period in Japan. Methods In a large (N = 1850), prospective, observational study, Japanese patients with schizophrenia who initiated treatment with olanzapine were followed for 1 year. Baseline characteristics were compared using t-tests and chi-square tests. Stepwise logistic regression was used to identify independent baseline predictors of treatment continuation. Results Most patients (68.2%) continued with olanzapine therapy for the full 1-year study period, with an average duration of 265.5 ± 119.4 days. At baseline, patients who continued were significantly more likely to be male, older, and inpatients; have longer illness duration, higher negative and cognitive symptoms, better health-related quality of life, and prior anticholinergic use. Continuers were significantly less likely to engage in social activities, live independently, work for pay, or have prior antidepressant use. Continuers showed significantly greater early (3-month) improvement in global symptom severity. Logistic regression found that continuation was significantly predicted by longer illness duration, lower positive symptoms, higher negative symptoms, and better health-related quality of life. Conclusions In this large naturalistic study in Japan, most patients with schizophrenia stayed on olanzapine therapy for the full 1-year study period. Treatment completion with olanzapine was independently predicted by longer illness duration, lower positive symptoms, higher negative symptoms, and better health-related quality of life.
A Single Institution-Based Retrospective Study of Surgically Treated Bronchioloalveolar Adenocarcinoma of the Lung: Clinicopathologic Analysis, Molecular Features, and Possible Pitfalls in Routine Practice

Introduction: Prognostic evaluation of bronchioloalveolar carcinoma (BAC) from a homogenous population of Caucasian patients. Methods: Retrospective analysis of resected BAC reclassified according to the 2004 World Health Organization classification of lung tumors. Analyzed variables are clinicoradiologic presentation, histologic subtypes, stage, epidermal growth factor receptor (EGFR) and HER2/neu immunohistochemical expression, EGFR exons 18, 19, and 21 mutations, K-RAS exon 2 mutation. Univariate and multivariate analyses of survival were performed. Results: Of 40 patients analyzed, EGFR and HER2/neu expression were detected in 72% and 20%, respectively. HER2/neu expression significantly characterized mucinous BAC (46% versus 7%; p = 0.014). EGFR mutations were identified in 17% (30% in nonmucinous BAC and none in mucinous BAC; p = 0.083). K-RAS mutations were found in 42.5% (92% in mucinous BAC versus 18% in other types; p < 0.0001). Early stages (IA+IB) nonmucinous BAC had excellent prognosis: 5 years overall survival of 91% (100% for stage IA). Sixty six percent (4 of 6) of patients with multifocal disease died (two mucinous BAC and one nonmucinous BAC with recurrent disease). Seventy one percent (5 of 7) of patients with pneumonic-like tumor (all mucinous BAC) died of recurrent/progressive disease. Stage (p = 0.004) and histologic classifications (p = 0.035) resulted as independent prognostic factors at multivariate analysis. Conclusions: Early stage nonmucinous BAC has excellent prognosis, whereas mucinous BAC presents a poor prognosis. Locally advanced nonmucinous BAC has a poor prognosis: the diagnosis of nonmucinous BAC in large tumors should be interpreted with caution given the possible presence of invasive areas in incompletely sampled tumor. Coexpression of EGFR and HER2/neu in mucinous BAC could be considered for future trials on target therapies even in Caucasian population.
On the Tropospheric Response to Anomalous Stratospheric Wave Drag and Radiative Heating

Observational and numerical evidence suggest that variability in the extratropical stratospheric circulation has a demonstrable impact on tropospheric variability on intraseasonal time scales. In this study, it is demonstrated that the amplitude of the observed tropospheric response to vacillations in the stratospheric flow is quantitatively similar to the zonal-mean balanced response to the anomalous wave forcing at stratospheric levels. It is further demonstrated that the persistence of the tropospheric response is consistent with the impact of anomalous diabatic heating in the polar stratosphere as stratospheric temperatures relax to climatology. The results contradict previous studies that suggest that variations in stratospheric wave drag are too weak to account for the attendant changes in the tropospheric flow. However, the results also reveal that stratospheric processes alone cannot account for the observed meridional redistribution of momentum within the troposphere.
The effect of crushed plastics waste on the structural properties of sandcrete blocks

The need for proper disposal of plastic waste has prompted researchers to consider the best way of recycling this non-biodegradable material. This research has looked into the production of sandcrete blocks, using shredded waste plastic in replacing fine aggregate at 0%, 5%, 10%, 15%, 20% and 100%. The laboratory experiments conducted were: compressive strength, flexural strength, density and water absorption tests. Both the compressive and flexural tests revealed that sandcrete blocks that contains 5% partial replacement of fine aggregate with shredded plastic have the highest strength when compared with other mixes, the density and water absorption test showed that the control sample has the best result. The study concluded that plastic waste can be used to partially replace fine aggregate in sandcrete block at not more than 5%.
Prestimulus Oscillatory Activity over Motor Cortex Reflects Perceptual Expectations

When perceptual decisions are coupled to a specific effector, preparatory motor cortical activity may provide a window into the dynamics of the perceptual choice. Specifically, previous studies have observed a buildup of choice-selective activity in motor regions over time reflecting the integrated sensory evidence provided by visual cortex. Here we ask how this choice-selective motor activity is modified by prior expectation during a visual motion discrimination task. Computational models of decision making formalize decisions as the accumulation of evidence from a starting point to a decision bound. Within this framework, expectation could change the starting point, rate of accumulation, or the decision bound. Using magneto-encephalography in human observers, we specifically tested for changes in the starting point in choice-selective oscillatory activity over motor cortex. Inducing prior expectation about motion direction biased subjects' perceptual judgments as well as the choice-selective motor activity in the 8–30 Hz frequency range before stimulus onset; the individual strength of these behavioral and neural biases were correlated across subjects. In the absence of explicit expectation cues, spontaneous biases in choice-selective activity were evident over motor cortex. These also predicted eventual perceptual choice and were, at least in part, induced by the choice on the previous trial. We conclude that both endogenous and explicitly induced perceptual expectations bias the starting point of decision-related activity, before the accumulation of sensory evidence.