Miracle-dz/UniFAR-FTUs huggingface dataset:
Critical care management of severe head injury in children.

BACKGROUND Our aim was to analyze prognostic factors and their association with outcome among children with severe head injury. METHODS We conducted a retrospective study among children (n=55) with severe head injury [Glasgow Coma Score (GCS) ? 8] who were admitted to our Neurosurgical Intensive Care Unit (ICU) from January 1996 to September 2003. The patients were immediately evaluated with cranial computed tomography (CT) for the severity of head injury as well as for the causes of secondary insults such as hypoxia and hypotension, metabolic and hematological alterations. Outcome analysis was assessed according to Glasgow Outcome Scale Score (GOS) six months after the injury. RESULTS A poor result occurred in 31 patients (57%) while 24 patients (43%) had favourable results. Multivariate analysis showed significant independent prognostic effect for admission mean systolic blood pressure, presence of hypoxia, multiple trauma, admission GCS score and multiple intracranial lesions (p<0.05). Admission WBC counts and serum glucose levels were not correlated with GOS. CONCLUSION This study describes clinicoradiologic findings and prognostic factors regarding severe head injury in pediatric patients. The goals of managements of pediatric patients with severe traumatic head injury include normalizing intracranial pressure, optimizing arterial blood gases and systemic blood pressure, and prevention of factors that exacerbate secondary brain injury.
First premolar extraction effects on upper airway dimension in bimaxillary proclination patients.

OBJECTIVE To determine how orthodontic treatment with first premolar teeth extracted and the associated arch dimensional changes in bimaxillary proclination patients affect the upper airway dimensions. MATERIALS AND METHODS Pre- and postorthodontic treatment cephalograms and dental casts of 40 bimaxillary proclination patients (ages ranged between 18 and 23 years) were used for this study. Patients were all treated with extraction of the four first premolars. Cephalometric radiographs were used to measure airway dimensions, and dental casts were used to measure the changes in the arch dimensions. A paired t-test was used to detect differences at P < . 05. RESULTS The results showed statistically significant reductions in tongue length (P < .05), posterior adenoids thickness (AD2-H) (P < .05), upper and lower incisor inclination, and lower incisor to A-Pog line (P < .001). Considering the dental cast results, statistically significant reductions in upper arch length, lower arch length, and lower intermolar width were also found (P < .001). The only statistically significant increase was recorded for the upper intercanine width (P < .001). CONCLUSIONS Extraction of the first premolars for the treatment of bimaxillary proclination does not affect upper airway dimensions despite the significant reduction in tongue length and arch dimensions.
Evaluation of feline immunodeficiency virus and feline leukemia virus transmembrane peptides for serological diagnosis

The general model for retrovirus transmembrane (TM) proteins proposed by Gallaher et al. (W. R. Gallaher, J. M. Ball, R. F. Garry, M. C. Griffin, and R. C. Montelaro, AIDS Res. Hum. Retroviruses 5:431-440, 1989) suggests that all retrovirus TM proteins may contain an immunodominant domain (Imd-TM peptide) located at the apex of the TM polypeptide. Although this Imd-TM peptide has been shown to be immunodominant in a variety of lentivirus infections, there has not been a detailed serological analysis of an oncovirus Imd-TM peptide as a diagnostic agent. We describe here an analysis of the antigenic properties and diagnostic potentials of the predicted Imd-TM peptides of feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) in serological assays of sera from infected cats. The results of these studies demonstrate that antibodies specific to the FIV Imd-TM peptide are detected within 2 weeks postinfection, are maintained at high levels for extended periods, and are not detectable in uninfected or FeLV-infected cats. In marked contrast, the FeLV Imd-TM peptide displayed only negligible levels of serological reactivity in FeLV-infected cats. These studies indicate that the peptide is a useful reagent for the detection of antibodies to FIV.
A comparison of spatial extreme value models. Application to precipitation data.

In this paper, focus is done on spatial models for extreme events and on their respective efficiency regarding the estimation of two risk measures: one extrapolating marginal distributions and one summarizing the spatial bivariate dependence of extremes. A wide comparison is performed on a simulation plan that has been specifically designed from a daily precipitation data set. The objective of this paper is twofold: firstly, pointing out the inherent properties of each model, and secondly, advising users on how to choose the model depending on the specific type of risk.
Expression of the p53 Target Wig-1 Is Associated with HPV Status and Patient Survival in Cervical Carcinoma

The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is frequently amplified in human tumors, including cervical cancer. We have examined the status of WIG-1 and the encoded Wig-1 protein in cervical carcinoma cell lines and tumor tissue samples. Our analysis of eight cervical cancer lines (Ca Ski, ME-180, MS751, SiHa, SW756, C-4I, C-33A, and HT-3) by spectral karyotype, comparative genomic hybridization and Southern blotting revealed WIG-1 is not the primary target for chromosome 3 gains. However, WIG-1/Wig-1 were readily expressed and WIG-1 mRNA expression was higher in the two HPV-negative cervical cell lines (C33-A, HT-3) than in HPV-positive lines. We then assessed Wig-1 expression by immunohistochemistry in 38 cervical tumor samples. We found higher nuclear Wig-1 expression levels in HPV-negative compared to HPV positive cases (p = 0.002) and in adenocarcinomas as compared to squamous cell lesions (p<0.0001). Cases with moderate nuclear Wig-1 staining and positive cytoplasmic Wig-1 staining showed longer survival than patients with strong nuclear and negative cytoplasmic staining (p = 0.042). Nuclear Wig-1 expression levels were positively associated with age at diagnosis (p = 0.023) and histologic grade (p = 0.034). These results are consistent with a growth-promoting and/or anti-cell death function of nuclear Wig-1 and suggest that Wig-1 expression can serve as a prognostic marker in cervical carcinoma.
Temporal and Spatial Variability of Oxygen Levels in Upwelled Waters Along the Southern California Coast

The overall goal of this study is to quantify interannual trends in oxygen concentrations and their spatial variability in the coastal Pacific Ocean off the southern coast of California, and to examine their relationship to concurrent hydrographic properties. The study focuses on trends within the upper 500 meters of the water column to indicate changes in seasonally upwelled waters over time. The analysis uses the publiclyavailable CalCOFI bottle cast data gathered and distributed by Scripps Institute. At each station, data include oxygen concentration and hydrographic information, such as potential density, depth, temperature, and salinity. This study utilizes data from 30.35° N and 34.21° N. Using MATLAB, data were bin-averaged and interpolated into quarterly time series at 24 stations and at standard depths. Figures were constructed to visualize latitudinal variability and cross-shelf variability of seasonal and interannual oxygen concentrations throughout the water column. Overall trends of oxygen at both standard depths and fixed density surfaces were approximated by a non-parametric linear fit. Observed multi-year trends in oxygen concentration are quantified and compared to those evident in hydrographic data under identical methods. Declining oxygen concentrations occur across the entire study region, peaking in the range of the California undercurrent. Deoxygenation rates maximize at equivalent magnitudes when viewed by both depth and density, reinforcing prior assertions that increasing advection of low oxygen Pacific Equatorial waters into the system is a strong driver of deoxygenation. On isopycnals, oxygen concentrations trends track best with salinity, suggesting salinity trends may be usable to predict oxygen trends.
The role of pitch range variation in the discourse structure and intonation structure of Korean

This study explores pitch range variation in Korean spontaneous narratives and read transcripts of the same narratives. There are two research goals. One is to examine whether pitch range variation helps mark discourse segment boundaries and signal the hierarchy of discourse segment purposes. Another is to see whether categorical differences in pitch range encode the contrast between the two intonationally marked units in the Korean prosodic hierarchy. The narratives were prosodically annotated for Accentual and Intonational Phrase boundaries and the F0 maximum was measured in each Accentual Phrase. Comparing F0 maxima across adjacent phrases shows that pitch range is reset at discourse segment boundaries in spontaneous speech, and also that size of the pitch range reset reflects the hierarchy of discourse segment levels. By contrast, there is no systematic difference in pitch range resetting values between higher Intonational Phrases as compared to lower Accentual Phrase boundaries.
Prevalence of Mental Health Problems and Factors Associated with Psychological Distress in Mountain Exercisers: A Cross-Sectional Study in Austria

Knowledge about potential protective factors against mental health problems is highly needed. Regular physical activity (PA) in an outdoor environment, like mountain exercising, might reduce psychological distress. Therefore, the aims of the present study were to assess the prevalence of mental health problems in mountain exercisers and to detect factors associated with psychological distress. In a cross-sectional design, we collected self-reported data of 1,536 Austrian mountain exercisers. The prevalence of mental health problems and psychological distress (Kessler Psychological Distress Scale), the level of PA International Physical Activity Questionnaire, and affective valence during PA (Feeling Scale) were obtained. Stepwise multiple linear regression analysis was conducted to assess factors influencing psychological distress. The prevalence of mental health problems in Austrian mountain exercisers was 14%. Health-enhancing PA level and higher affective valence during PA were significantly associated with lower psychological distress. Minimal PA level was not significantly associated with lower psychological distress compared to inactive PA level. Marital status, education, alpine association membership, and body mass index did not show a significant influence on psychological distress. The prevalence of mental health problems seems to be lower in Austrian mountain exercisers compared to the European population. A health-enhancing PA level and affective valence increasing forms of PA were shown to be associated with lower psychological distress. Results might lead to interventional studies focusing on the potential of outdoor PA, e.g., mountain exercise, as an adjunct treatment in people at risk or with mental health problems.
Effect of tension on contraction-induced glucose transport in rat skeletal muscle.

We questioned the general view that contraction-induced muscle glucose transport only depends on stimulation frequency and not on workload. Incubated soleus muscles were electrically stimulated at a given pattern for 5 min. Resting length was adjusted to achieve either no force (0% P), maximum force (100% P), or 50% of maximum force (50% P). Glucose transport (2-deoxy-d-glucose uptake) increased directly with force development ( P < 0.05) [27 ± 2 (basal), 45 ± 2 (0% P), 68 ± 3 (50% P), and 94 ± 3 (100% P) nmol ⋅ g-1 ⋅ 5 min-1]. Glycogen decreased at 0% P but did not change further with force development ( P > 0.05). Lactate, AMP, and IMP concentrations were higher ( P < 0.05) and ATP concentrations lower ( P < 0.05) when force was produced than when it was not. 5'-AMP-activated protein kinase (AMPK) activity increased directly with force [20 ± 2 (basal), 60 ± 11 (0% P), 91 ± 12 (50% P), and 109 ± 12 (100% P) pmol ⋅ mg-1 ⋅ min-1]. Passive stretch (∼86% P) doubled glucose transport without altering metabolism. In conclusion, contraction-induced muscle glucose transport varies directly with force development and is not solely determined by stimulation frequency. AMPK activity is probably an essential determinant of contraction-induced glucose transport. In contrast, glycogen concentrations per se do not play a major role. Finally, passive stretch per se increases glucose transport in muscle.
Predictors of cognitive impairment in advanced Parkinson’s disease

Objective: To investigate the cognitive profile of patients with idiopathic Parkinson’s disease and to determine the demographic and medical variables that contribute to the cognitive outcome. Design: Retrospective cohort analysis. Methods: 100 patients with idiopathic Parkinson’s disease were given a neuropsychological test battery investigating attention, memory, and visuospatial and executive functions. Test performance was compared against normative data, and linear regression determined significant predictors of cognitive impairment from a set of demographic and disease course variables. Results: Frontal-type cognitive dysfunction was widespread in patients with advanced Parkinson’s disease. Attention and memory were mildly to moderately impaired, whereas visuospatial function showed only subtle impairment. Older age and tremor at onset were significant predictors of poor cognitive performance. Conclusions: The observed cognitive impairment in patients with advanced Parkinson’s disease is more than expected for normal aging. Although in apparent contrast with most previous research, reporting a greater risk of cognitive dysfunction in Parkinson’s disease patients with predominant akinesia/rigidity, tremor at onset may be a marker for more widespread brain pathology that contributes to an increased risk of cognitive impairment.
Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels

Leptin reduces body weight in ob/ob mice by decreasing food intake and increasing energy expenditure; however, the mechanisms by which it does the latter are not known. Here we report that 30% of the weight loss induced by leptin treatment of ob/ob mice is due to changes in energy expenditure. In assessing leptin's effects on specific tissues, we found that hepatic basal metabolic rate was paradoxically decreased 1.7-fold with leptin treatment, which was the result of a 1.6-fold reduction in mitochondrial volume density and altered substrate oxidation kinetics. The altered kinetics were associated with a decrease in protein levels of 2 mitochondrial respiratory chain components—cytochrome c oxidase subunit VIa and cytochrome c oxidase subunit IV. In addition to reduced hepatic metabolism, there was reduced long chain fatty acid production and a 2.5-fold increase in hepatic lipid export, both of which explain the reduced steatosis in leptin-treated animals. These data help clarify the role of the liver in leptin-mediated weight loss and define the mechanisms by which leptin alters hepatic metabolism and corrects steatosis.
Escitalopram in major depressive disorder: clinical benefits and cost effectiveness versus citalopram

Objective. Escitalopram is the most selective of the serotonin reuptake inhibitors. Methods. We review all the clinical trials (three pivotal placebo-controlled trials with citalopram as an active reference, one long-term non-inferiority study and one head-to-head superiority study) that include citalopram as an active reference in major depressive disorder (MDD), and studies that evaluate the cost-effectiveness of the two drugs. Results. In two of the pivotal studies and in the long-term study, escitalopram was numerically better than citalopram in reducing Montgomery-Åsberg Depression Rating Scale (MADRS) scores from baseline, with comparative tolerability. Meta-analyses of these studies showed statistically significant differences in favour of escitalopram in terms of reducing MADRS and increasing response. This effect was particularly apparent in patients with higher baseline MADRS scores. These trends were confirmed in a head-to-head study, which clearly demonstrated the superiority of escitalopram compared with citalopram on primary and secondary endpoints. The difference between treatments was clinically relevant. Cost-effectiveness analyses demonstrated that although escitalopram has a slightly higher unit cost than generic citalopram, expected direct medical and productivity- related costs were lower with escitalopram than citalopram. Conclusion. On the basis of these results, escitalopram was concluded to be more clinically effective and more cost-effective than citalopram for the treatment of MDD, with a similar tolerability profile.
Slow light in semiconductor heterostructures

This paper presents an overview of slow light in semiconductor heterostructures. The focus of this paper is to provide a unified framework to summarize and compare various physical mechanisms of slow light proposed and demonstrated in the past few years. We expand and generalize the discussions on fundamental limitation of slow light and the delay–bandwidth product trade-off to include gain systems and other mechanisms such as injection locking. We derive the maximum fractional delay and compare the differences between material dispersion and waveguide dispersion based devices. The delay–bandwidth product is proportional to the square root of the device length for a material dispersion based device but has a linear relationship for a waveguide dispersion based device. Possible scenarios to overcome the delay–bandwidth product limitation are discussed. The prospects of slow light in various applications are also investigated.
Carotid Artery Anatomy and Geometry as Risk Factors for Carotid Atherosclerotic Disease

Background and Purpose— Traditional vascular risk factors do not completely explain the asymmetry, racial, and sex differences in carotid artery disease. Carotid anatomy and geometry may play a role in the pathogenesis of internal carotid artery (ICA) stenosis, but their effects are unknown. We hypothesized that carotid artery anatomy and geometry would be independently associated with ICA stenosis. Method— This is a retrospective study of patients with CT angiography at Monash Medical Centre, 2006 to 2007. Carotid arteries were segmented using semiautomated methods to estimate measures of carotid anatomy and geometry. Measurements of carotid artery geometry were performed according to the recent article by Thomas and colleagues. ICA stenosis was dichotomized as <30% or ≥30% stenosis. Cluster logistic regression was used to examine the associations of anatomy and geometry with stenosis accounting for the paired arteries within subjects, adjusting for age, sex, and vascular risk factors. Results— Mean age of the sample (n=178) was 68.4 years (SD, 14 years). The following were independently associated with ICA stenosis: ICA radius at the bifurcation (OR, 0.20; 95% CI, 0.14–0.29), ICA angle (OR, 1.05 per degree increment; 95% CI, 1.04–1.07), age (OR, 1.05 per year increment; 95% CI, 1.03–1.07), male sex (OR, 1.72; 95% CI, 1.08–2.8), and ever-smoker (OR, 1.85; 95% CI, 1.15–2.96). Conclusions— Carotid anatomy and geometry may enhance the risk of stenosis independent of traditional vascular risk factors and may be of help in very early identification of patients at high risk of developing carotid artery atherosclerosis for aggressive intervention.
Shortening of the QT Interval After Food Can Be Used to Demonstrate Assay Sensitivity in Thorough QT Studies

The effect of food was investigated under conditions of a thorough QT (TQT) study and with confirmation of assay sensitivity by the use of a positive control (400 mg of moxifloxacin). Fifty‐five healthy subjects were randomized to treatment and a sequence of fasted and fed baseline electrocardiography days. Subjects received standard breakfast 30 to 10 minutes prior to dosing. Measurement of QT interval was performed automatically with subsequent manual onscreen overreading using electronic calipers. A profound increase in heart rate of 9.4 bpm was observed in the fed condition compared with the fasted condition at 1.5 hours after dose with a corresponding shortening of QT (27 milliseconds); (baseline data). When corrected, QTcF interval was shortened significantly with the maximal effect observed at 2 hours after dose of 8.2 (95% confidence interval, 6–10) milliseconds. A concurrent shortening of the PR interval with a maximum value of 5.6 milliseconds was also observed. The findings of this study demonstrate that food alters the QT‐RR relationship and shortens QTc and PR for at least 4 hours after a carbohydrate‐rich meal. The findings are of regulatory interest as this study shows that normal physiological causes can shorten QTc significantly and that it could be used as a method to demonstrate assay sensitivity.
Optimization of Zygosity Determination by Questionnaire and DNA Genotyping in Chinese Adolescent Twins

Abstract The main aim of this study was to develop and optimize a questionnaire-based zygosity determination method in Chinese adolescent twins. Participants were 471 pairs of same-sex twins (345 monozygotic, 126 dizygotic) with a mean age of 14.56 years (SD = 2.62). A second sample was recruited for cross-validation, including 382 pairs of same-sex twins (261 monozygotic, 121 dizygotic) with a mean age of 12.53 years (SD = 2.22). The questionnaire consisted of 12 questions dealing with co-twin similarity or frequency of confusion. Two means were put forward to improve the predictive accuracy of the questionnaire — adding parent-reports to the analysis, and using a 2-point rather than 3-point response format. DNA genotyping was performed on nine short tandem repeat loci, with an estimated zygosity classification accuracy very close to 100%. The validity of all questionnaires was assessed by being compared to the results of DNA analysis. Results of stepwise logistic regression analysis showed that the predictive accuracy of the 3-point self-reported questionnaire is 83.8%. Using parent-reports and 2-point scale led to 3.9% and 4.6% increase in predictive accuracy, respectively. When using the parent-reports and children's self-reports jointly, the predictive accuracy was enhanced to 90.6%. For the cross-validation, the equations and cut-offs derived from the first sample led to an acceptable accuracy (91.3%) in the second sample. In conclusion, the method we developed can be used in future studies among Chinese adolescent twins. Multiple-rater and 2-point response format were suggested for all twin studies for enhancing the predictive accuracy of questionnaires.
Quality Parameters, Nutrient Content and Uptake as Influenced by INM in Wheat (Triticum aestivum L.) under Saline and Non-Saline Irrigation Water

Wheat (Triticum aestivum L.) is the second most important staple food crop at global scenario after rice. Quality parameters of flour viz., colour, appearance etc. are very much important for preparation of final products like bread, chapatti, biscuits etc. In the present investigation various physico-chemical parameters like sedimentation value, protein content and hectoliter weight were determined to study the impact of treatments. Sedimentation value gives an idea of the gluten strength. End use quality of wheat is influenced by quantity and quality of gluten proteins and latter is responsible for selection International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 05 (2018) Journal homepage: http://www.ijcmas. com