Miracle-dz/UniFAR-FTUs huggingface dataset:
High Performance Data Persistence in Non-Volatile Memory for Resilient High Performance Computing

Resilience is a major design goal for HPC. Checkpoint is the most common method to enable resilient HPC. Checkpoint periodically saves critical data objects to non-volatile storage to enable data persistence. However, using checkpoint, we face dilemmas between resilience, recomputation and checkpoint cost. The reason that accounts for the dilemmas is the cost of data copying inherent in checkpoint. In this paper we explore how to build resilient HPC with non-volatile memory (NVM) as main memory and address the dilemmas. We introduce a variety of optimization techniques that leverage high performance and non-volatility of NVM to enable high performance data persistence for data objects in applications. With NVM we avoid data copying; we optimize cache flushing needed to ensure consistency between caches and NVM. We demonstrate that using NVM is feasible to establish data persistence frequently with small overhead (4.4% on average) to achieve highly resilient HPC and minimize recomputation.
Evaluation of Gender and Equity Issues Under Sarva Shiksha Abhiyaan

In the last 50 years, India has made significant progress in the field of education. Yet, there are huge challenges, especially when it comes to bridging gender and equity gaps in education. In 2001, the Government of India (GOI) had launched Sarva Shiksha Abhiyaan (SSA) with the specific purpose of achieving universal elementary education (UEE). One of the main goals of SSA is to bridge gender and social gaps. Even though the SSA programme is primarily financed by the GOI, three external Development Partners (DP) also contribute funds towards SSA, namely: World Bank’s International Development Association (IDA), the United Kingdom’s Department for International Development (DFID) and the European Union (EU). Being a partnership programme, a six monthly review is carried out by the GOI and DP, which is known as the Joint Review Mission (JRM). This desk review was conceptualised with the purpose of doing a thorough review of monitoring and evaluation processes of SSA JRM reports in order to understand how gender and equity goals have been tracked and addressed by the government and donor partners. More specifically, this study also explores how equity and gender have been understood within the SSA framework; whether the SSA JRM mechanism focuses on input indicators, process indicators and/or output indicators; and what are the various gender-related issues that have been flagged in SSA JRM reports and recommendations made over the years?
Varicella-zoster virus gene 63 encodes an immediate-early protein that is abundantly expressed during latency

Varicella-zoster virus (VZV) gene 63 encodes a protein with a predicted molecular mass of 30.5 kDa which has amino acid similarities with the immediate-early (IE) protein 22 (ICP-22) of herpes simplex virus type 1. In order to study the expression of this protein during lytic and latent infection, gene 63 was cloned in frame and downstream from the glutathione-S-transferase gene, expressed as a fusion protein, and purified. In VZV-infected Vero cells, antibodies directed against this protein detect two polypeptides of 45 and 38 kDa which are localized both in the cytoplasm and in the nucleus. Using a sequential combination of transcription and protein synthesis inhibitors (actinomycin D and cycloheximide, respectively), we demonstrated the immediate-early nature of this protein, which can thus be named IE63. Using a rat model of VZV latency, we showed that IE63 is heavily expressed, essentially in neurons, during latency. IE63 can also be detected in the skin of patients showing early herpes zoster symptoms.
Continuous Theta Burst Stimulation (cTBS) on Left Cerebellar Hemisphere Affects Mental Rotation Tasks during Music Listening

Converging evidence suggests an association between spatial and music domains. A cerebellar role in music-related information processing as well as in spatial-temporal tasks has been documented. Here, we investigated the cerebellar role in the association between spatial and musical domains, by testing performances in embodied (EMR) or abstract (AMR) mental rotation tasks of subjects listening Mozart Sonata K.448, which is reported to improve spatial-temporal reasoning, in the presence or in the absence of continuous theta burst stimulation (cTBS) of the left cerebellar hemisphere. In the absence of cerebellar cTBS, music listening did not influence either MR task, thus not revealing a “Mozart Effect”. Cerebellar cTBS applied before musical listening made subjects faster (P = 0.005) and less accurate (P = 0.005) in performing the EMR but not the AMR task. Thus, cerebellar inhibition by TBS unmasked the effect of musical listening on motor imagery. These data support a coupling between music listening and sensory-motor integration in cerebellar networks for embodied representations.
Impaired results of a randomised double blinded clinical trial of propranolol versus placebo on the expansion rate of small abdominal aortic aneurysms.

BACKGROUND To study the propranolol treatment of small abdominal aortic aneurysms (AAA) concerning intention to treat, side effects, and inhibition of expansion. METHODS DESIGN Two-year lasting prospective randomised double-blinded intervention trial. SETTING Hospital-based mass screening for AAA with annual ambulatory control of small AAA. PARTICIPANTS Of 122 screening-diagnosed small AAA, 51 (42%) were excluded because of contraindications or present beta-blockage, and 17 refused participation. Thus, 54 (44.3%) were included. INTERVENTION Participants were randomised to 40 mg propranolol twice a day or placebo. MEASURES The same observed was used to follow-up AAA-expansion, side effects, quality of life (QL), branchial and ankle blood pressure (ABI), and pulmonary function (FEV1 and FVC). RESULTS Sixty percent in the propranolol group, and 25% in the placebo group dropped out, mainly caused by dyspnoea in the propranolol group (RR=1.74, 95% C.I.: 1.06-2.86). Five (16.7%) died in the propranolol group, while 1 (4.2%) died in the placebo group (RR=1.6 (1.02-2.51)). Furthermore, decreased pulmonary function, ABI, and QL was noticed in the propranolol group. Consequently, the trial was stopped after two years. Ninety-five percent of the measurements of the AAA were measured within 2 mm variation. If expansion was defined as above 2 mm annually, the relative risk of expansion in the placebo group was 1.17 (0.74-1.85), and 2.44 (0.88-6.77) among the non-drop-outs. CONCLUSIONS Only 22% of small screenings-diagnosed AAA were treatable with propranolol for two years. Consequently, only large scale studies are capable of showing potential minor inhibition of expansion by propranolol. However, whether such treatment ever becomes ethically acceptable is debatable.
Self-Claimed and Tested Knowledge

an opportunity for him to demonstrate his knowledge. The person is asked to indicate, through recall or recognition, the answer to a question and the person asking the question then decides regarding the correctness or appropriateness of the answer. The decision regarding the person’s knowledge is a function of what he actually knows, the way the question is asked, and the way the judgment is made concerning the correctness of the answer. The assumption is made that if a question is asked of a person and he answers the question in the proper way, he has the information, and if he does not answer the question properly, he does not have the information. An alternative method to determine whether or not a person knows something is to ask him if he knows it. Thus one can present an individual with a list of laws, principles, persons, or facts and ask the person to check or otherwise indicate the ones with which
A hybrid history based weighted voting algorithm for ultra-critical systems

There are numerous fault management techniques that can be used to enhance the reliability of a real-time critical system. Fault masking is one of the significant techniques amid those. It is one of the key approaches to improve or maintain the normal behaviour of a system in the appearance of fault. Voting as fault masking method involves the derivation of an output data object from a collection of n input data objects, as prescribed by the requirements and constraints of a voting algorithm. In data fusion, voting is a probable method of combining different data delivered by several sources (e.g. sensors) whose outputs may be mistaken. This paper proposes a new concept of classifying voting algorithms with some new parameters of evaluation. Then using this new concept and some widely known voting algorithms, we propose a hybrid history based weighted voting algorithm. We show that the proposed algorithm gives better and stable performance, in different error ranges, compared to the existing standard voting algorithms.
Procedural Justice, Work Engagement, and Job Outcomes: Evidence from Nigeria

A research model investigating work engagement as a full mediator of the effects of procedural justice on affective organizational commitment, job performance, and extra-role customer service was developed and tested. Data were gathered from a sample of full-time frontline employees of the four- and five-star hotels with a 1-week time lag and their immediate supervisors in Abuja, the capital city of Nigeria. We tested the relationships using hierarchical multiple regression analysis. All hypothesized relationships were supported. Specifically, the results revealed that work engagement fully mediated the effects of procedural justice on affective organizational commitment, job performance, and extra-role customer service. Implications of the results are discussed and directions for future research are offered.
Impact of pH and cationic supplementation on in vitro postantibiotic effect

Most studies on pharmacodynamic variables in vitro, including the postantibiotic effect (PAE), are performed at pH 7.4 in noncationic-supplemented media, a situation which may differ significantly from the true microenvironment in most infected foci. We studied the impact of five different pH levels (pH 5, 6, 7, 7.4, and 8) on the duration of the PAE, the MIC, and bactericidal activity. Acid pH was found to have in general a deleterious effect on the activity of aminoglycosides and ciprofloxacin against Escherichia coli and Pseudomonas aeruginosa, with the MIC being higher, the bactericidal rate being lower, and the PAE being shorter at pH 5 (and to a lesser extent at pH 6) than at more alkaline pH levels. Similar results were observed for imipenem against P. aeruginosa. The PAEs induced by ampicillin against E. coli and dicloxacillin against Staphylococcus aureus were not predictably dependent on the pH, whereas the PAEs induced by ciprofloxacin against S. aureus were longest at either end of the pH spectrum. The bactericidal activity of these agents was, however, pH dependent, being slower at acid pHs. The addition of 50 mg of Ca2+ and 20 mg of Mg2+ per liter of liquid medium at pH 7.4 did not affect the duration of the PAE. Since the pH in abscess cavities may be close to 5, these observations may be of importance for employment of the agents studied in closed or poorly drained infections.
Long Term Prognosis After Healed Amputation in Patients With Diabetes

In this prospective study, mortality, rehabilitation, and new amputations on the same or on the contralateral leg were studied in 189 patients with diabetes who had achieved healing of an index amputation. Ninety-three patients had achieved healing after an index minor (below the ankle) and 96 after an index major (above the ankle) amputation, precipitated by a foot ulcer. The healing time was 29 weeks (range, 3–191 weeks) with a minor amputation and 8 weeks (range, 3–104 weeks) with a primary major amputation. The mortality 1, 3, and 5 years after the index amputation was 15%, 38%, and 68%, respectively, and was higher in patients who had achieved healing after major amputation than in patients achieving healing after minor amputation. The rate of new amputations after 1, 3, and 5 years of observation was 14%, 30%, and 49%, respectively. There was no difference among patients with an index minor and those with an index major amputation. The rate of new major amputations was 9%, 13%, and 23%, respectively, and was higher in patients with an index major amputation. Eighty-five percent of new amputations were precipitated by a foot ulcer. Patients living independently before the index amputation returned to living independently more often after a minor than a major amputation (93% versus 61%). One year after the index amputation, 70% of patients who had achieved healing after having a minor amputation and who could walk 1 km or more before amputation had regained this walking capacity, compared with 19% of patients having a major amputation. Seventy percent of patients with an index transtibial amputation who could walk before amputation were fitted with a prosthesis, and 52% were using it regularly. Patients with diabetes who had an index major amputation had a higher mortality, an equal rate of new amputation, and a lower rehabilitation potential than did patients who had an index minor amputation.
Sesquiterpenoids and Lignans from the Roots of Valeriana officinalis L.

Two new guaiane‐type sesquiterpenoids, valerol A (1) and kessyl 3‐acetate (2), together with nine known compounds, valeracetate (3), anismol A (4), orientalol C (5), spatulenol (6), 4α,10α‐epoxyaromadendrane (7), (+)‐8‐hydroxypinoresinol (8), pinorespiol (9), pinoresinol 4‐O‐β‐D‐glucopyranoside (10), and 8‐hydroxypinoresinol 4′‐O‐β‐D‐glucopyranoside (11) were isolated from the roots of Valeriana officinalis. The structures and relative configurations of 1 and 2 were elucidated on the basis of spectroscopic methods (1D‐ and 2D‐NMR, MS, UV, and IR). These compounds were evaluated for inhibitory activity on acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)‐mediated neurite outgrowth in PC12 cells.
Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

Formation of pathogenic antibodies is a major problem in replacement therapies for inherited protein deficiencies. For example, antibodies to coagulation factors (‘inhibitors’) seriously complicate treatment of haemophilia. While immune tolerance induction (ITI) protocols have been developed, inhibitors against factor IX (FIX) are difficult to eradicate due to anaphylactic reactions and nephrotic syndrome and thus substantially elevate risks for morbidity and mortality. However, hepatic gene transfer with an adeno‐associated virus (AAV) serotype 8 vector expressing FIX (at levels of ≥4% of normal) rapidly reversed pre‐existing high‐titre inhibitors in haemophilia B mice, eliminated antibody production by B cells, desensitized from anaphylaxis (even if protein therapy was resumed) and provided long‐term correction. High levels of FIX protein suppressed memory B cells and increased Treg induction, indicating direct and indirect mechanisms of suppression of inhibitor formation. Persistent presence of Treg was required to prevent relapse of antibodies. Together, these data suggest that hepatic gene transfer‐based ITI provides a safe and effective alternative to eradicate inhibitors. This strategy may be broadly applicable to reversal of antibodies in different genetic diseases.
Denervation suppresses gastric tumorigenesis

Surgical or pharmacologic interruption of muscarinic innervation to the stomach suppresses gastric tumor growth in mice and humans. Treating Cancer by Getting on Its Nerves The nervous system plays a role in the regulation of many different organs, including the gut. Now, Zhao et al. have shown that the vagal nerve, which signals to the stomach through muscarinic receptors, contributes to the growth of gastric tumors. The authors demonstrated that vagotomy (surgical interruption of the vagal nerve) can prevent gastric cancer in mice and reduce the recurrence of gastric tumors in human patients. Moreover, the same result can be achieved in mice treated with Botox or anticholinergic drugs to inhibit vagal nerve signaling, raising the hope of a safer treatment for gastric cancer without irreversible side effects. The nervous system plays an important role in the regulation of epithelial homeostasis and has also been postulated to play a role in tumorigenesis. We provide evidence that proper innervation is critical at all stages of gastric tumorigenesis. In three separate mouse models of gastric cancer, surgical or pharmacological denervation of the stomach (bilateral or unilateral truncal vagotomy, or local injection of botulinum toxin type A) markedly reduced tumor incidence and progression, but only in the denervated portion of the stomach. Vagotomy or botulinum toxin type A treatment also enhanced the therapeutic effects of systemic chemotherapy and prolonged survival. Denervation-induced suppression of tumorigenesis was associated with inhibition of Wnt signaling and suppression of stem cell expansion. In gastric organoid cultures, neurons stimulated growth in a Wnt-mediated fashion through cholinergic signaling. Furthermore, pharmacological inhibition or genetic knockout of the muscarinic acetylcholine M3 receptor suppressed gastric tumorigenesis. In gastric cancer patients, tumor stage correlated with neural density and activated Wnt signaling, whereas vagotomy reduced the risk of gastric cancer. Together, our findings suggest that vagal innervation contributes to gastric tumorigenesis via M3 receptor–mediated Wnt signaling in the stem cells, and that denervation might represent a feasible strategy for the control of gastric cancer.
Using Cogenerative Dialogues to Foster Community and Support English Language Learner Students' Learning

Given the collaborative nature of the TESOL profession, models are needed that provide opportunities for teachers and other school-based stakeholders to interact with students to understand their successes, challenges, and particular needs more clearly. In this article, the authors advocate for the use of cogenerative dialogues, a promising practice for learning more about the teaching and learning needs of English language learners (ELLs) in a specific learning context. Cogenerative dialogues are discussions involving students and teachers that foreground problems and generate strategies to improve teaching and learning. The dialogues were implemented as part of a larger, mixed-methods study in two urban middle school science classrooms in the United States. The authors discuss beneficial outcomes and tensions for both ELL students and teachers. Benefits included (1) creating opportunities for students to develop a voice, (2) assuming responsibilities for learning, (3) sharing responsibilities for language acquisition and learning, and (4) developing a sense of community. They also address two other specific concerns: the language proficiency levels of the students who are involved, and the cultural practices around critiquing teaching and learning.
Development of word reading fluency along primary education: a six-year follow-up / El desarrollo de la fluidez en la lectura de palabras en educación primaria: un seguimiento longitudinal de seis años

Abstract Word reading fluency is a key component in the process of reading. In order to understand its acquisition it is crucial to conduct longitudinal studies. The aim of this work was to describe the development of word recognition in Spanish, considering accuracy and speed, from a longitudinal perspective. A group of 31 children were followed for six years. Reading performance was assessed with a list of 72 stimuli in which lexicality, frequency and length were manipulated. Results show that initial gains in reading accuracy occurred very rapidly. However, the growth of reading speed was found to be more difficult and complex, and automatic word recognition remains low at the end of Grade 6. Low frequency, long words were the most difficult stimuli. High stability in reading speed was observed and it was a relevant indicator that differentiates between good and poor readers. The findings also highlighted the need to develop training programs with the specific aim of improving word reading fluency throughout primary education.
PHYTOCHEMICAL SCREENING, ANTI-INFLAMMATORY AND ANALGESIC PROPERTIES OF PENTANISIA PRUNELLOIDES FROM THE EASTERN CAPE PROVINCE, SOUTH AFRICA

Background: Pentanisia prunelloides is a medicinal plant widely used to remedy various ailments including infections, fever and rheumatism in Eastern Cape Province of South Africa. There is scanty report on the phytochemical and biological properties of the plant; hence various solvent extracts of the dried plant materials were phytochemically screened, and its aqueous extract evaluated for acute toxicity effect, analgesic and antiinflammatory properties in rodents. Methods and Materials: Different extracts of both leaf and rhizome were obtained separately with ethanol, methanol and water. Portions of the filtrate were used for qualitative screening of secondary metabolites and remaining portions were concentrated and dried. Dried grounded leaf and rhizome of the plant were also used for quantitative screening for some major components. The aqueous extract of the leaf and rhizome were used for acute toxicity (LD50) test, antiinflammatory and analgesic activities in rodents. Results: The qualitative phytochemical screening showed the presence of several phytoconstituents with saponins, flavonoids and alkaloids constituting highest constituents in the leaf and rhizome. The LD50: of the aqueous extracts (from leaf or rhizome) was found to be ≥5000 mg/kg orally. The leaf and rhizome aqueous extract (250-500 mg/kg) significantly (p<0.01) reduced egg albumin-induced paw oedema and paw licking in mice induced by formalin, signifying antinociceptive and antiinflammatory activities respectively. Conclusion: It is concluded that the leaf and rhizome of P. prunelloides are rich in various phytochemicals which could be associated with their medicinal uses. The aqueous leaf and rhizome extracts are similarly non-toxic orally, showed antiinflammatory and analgesic potentials thus rationalizing its use in folkloric medicine.
Robust and Efficient Methods for Approximation and Optimization of Stability Measures

We consider two new algorithms with practical application to the problem of designing controllers for linear dynamical systems with input and output: a new spectral value set based algorithm called hybrid expansion-contraction intended for approximating the H∞ norm, or equivalently, the complex stability radius, of large-scale systems, and a new BFGS SQP based optimization method for nonsmooth, nonconvex constrained optimization motivated by multi-objective controller design. In comprehensive numerical experiments, we show that both algorithms in their respect domains are significantly faster and more robust compared to other available alternatives. Moreover, we present convergence guarantees for hybrid expansion-contraction, proving that it converges at least superlinearly, and observe that it converges quadratically in practice, and typically to good approximations to the H∞ norm, for problems which we can verify this. We also extend the hybrid expansion-contraction algorithm to the real stability radius, a measure which is known to be more difficult to compute than the complex stability radius. Finally, for the purposes of comparing multiple optimization methods, we present a new visualization tool called relative minimization profiles that allow for simultaneously assessing the relative performance of algorithms with respect to three important performance characteristics, highlighting how these measures interrelate to one another and compare to the other competing algorithms on heterogenous test sets. We employ relative minimization profiles to empirically validate our proposed BFGS SQP method in terms of quality of minimization, attaining feasibility, and speed of progress compared to other available methods on challenging test sets comprised of nonsmooth, nonconvex constrained optimization problems arising in controller design.