Miracle-dz/UniFAR-FTUs huggingface dataset:
Pulmonary Vein Antral Isolation and Nonpulmonary Vein Trigger Ablation Are Sufficient to Achieve Favorable Long-Term Outcomes Including Transformation to Paroxysmal Arrhythmias in Patients With Persistent and Long-Standing Persistent Atrial Fibrillation

Background—Transformation from persistent to paroxysmal atrial fibrillation (AF) after ablation suggests modification of the underlying substrate. We examined the nature of initial arrhythmia recurrence in patients with nonparoxysmal AF undergoing antral pulmonary vein isolation and nonpulmonary vein trigger ablation and correlated recurrence type with long-term ablation efficacy after the last procedure. Methods and Results—Three hundred and seventeen consecutive patients with persistent (n=200) and long-standing persistent (n=117) AF undergoing first ablation were included. AF recurrence was defined as early (⩽6 weeks) or late (>6 weeks after ablation) and paroxysmal (either spontaneous conversion or treated with cardioversion ⩽7 days) or persistent (lasting >7 days). During median follow-up of 29.8 (interquartile range: 14.8–49.9) months, 221 patients had ≥1 recurrence. Initial recurrence was paroxysmal in 169 patients (76%) and persistent in 52 patients (24%). Patients experiencing paroxysmal (versus persistent) initial recurrence were more likely to achieve long-term freedom off antiarrhythmic drugs (hazard ratio, 2.2; 95% confidence interval, 1.5–3.2; P<0.0001), freedom on/off antiarrhythmic drugs (hazard ratio, 2.5; 95% confidence interval, 1.6–3.8; P<0.0001), and arrhythmia control (hazard ratio, 5.2; 95% confidence interval, 2.9–9.2; P<0.0001) after last ablation. Conclusions—In patients with persistent and long-standing persistent AF, limited ablation targeting pulmonary veins and documented nonpulmonary vein triggers improves the maintenance of sinus rhythm and reverses disease progression. Transformation to paroxysmal AF after initial ablation may be a step toward long-term freedom from recurrent arrhythmia.
Effects of Gly71Arg mutation in UGT1A1 gene on neonatal hyperbilirubinemia: a systematic review and meta-analysis

Abstract Objective: The associations between Gly71Arg polymorphism in the coding region of uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene and the risk of neonatal hyperbilirubinemia remained controversial. Therefore, a meta-analysis of observational studies has been conducted to assess the relationship between UGT1A1 gene polymorphism of Gly71Arg and neonatal hyperbilirubinemia susceptibility. Methods: An electronic literature search from online databases, such as PubMed, Embase, Cochrane, and Scopus was conducted to identify eligible studies. The effect summary odds ratio (OR) with 95% confidence interval (CI) was used to estimate the strength of association in the fixed or random effects model, based on the absence or presence of heterogeneity. Results: A total of 32 eligible studies involving 2634 cases of neonatal hyperbilirubinemia and 4996 controls were enrolled in this meta-analysis. The combined results showed that UGT1A1 Gly71Arg polymorphism was associated with an increased risk of neonatal hyperbilirubinemia in all genetic models (homozygote model: OR = 6.12, 95% CI = 4.42–8.46; heterozygote model: OR = 2.06, 95% CI = 1.82–2.33; dominant model: OR = 2.44, 95% CI = 2.03–2.93; recessive model: OR = 4.79, 95% CI = 3.48–6.59, and allelic model: OR = 2.37, 95% CI = 1.98–2.82). Subgroup analysis by ethnicity strongly validated this correlation in Asians but slightly in Caucasian population. Conclusions: This meta-analysis confirms that UGT1A1 Gly71Arg polymorphism significantly increases the risk of neonatal hyperbilirubinemia in Asian population, but results from the Caucasians were conflicting and further well-designed epidemiological studies are, therefore, required to more adequately assess this correlation.
Ultrasonic assessment of human and bovine trabecular bone: a comparison study

A comparison study is reported on the ultrasonic assessment of human trabecular and bovine trabecular bone samples. Both ultrasonic velocity and ultrasonic attenuation were evaluated through a transmission insertion technique and correlated with bone mineral density as determined with single photon absorptiometry. For a 1 MHz ultrasonic transducer pair and the human cancellous bone samples the correlations were 0.91 and 0.89 between density and velocity and attenuation, respectively. For a 500 kHz ultrasonic transducer pair the correlations were 0.89 and 0.81 between density and velocity and attenuation, respectively. For the bovine bone samples, the correlations were 0.90 and -0.31 for the velocity and attenuation, respectively, for the 1 MHz transducer pair. For the 500 kHz transducers, the correlations were 0.85 and -0.17 for the velocity and attenuation, respectively. By combining both velocity and attenuation in a multivariate regression, an improvement was achieved in the estimation of bone density in the human samples for both the 500 kHz and 1 MHz transducer pairs. No significant improvement was achieved in the multivariate regressions for the bovine bone samples. In conclusion, the results indicate that ultrasonic measurements are in general highly correlated with bone mineral density in trabecular bone samples. This correlation is more consistent and strong in relatively low density human samples compared with the higher density bovine samples.
One Classroom at a Time? Teacher Isolation and Community Viewed through the Prism of the Particular

In recent years a research literature has developed which increasingly problematizes the project to construct professional community in schools. This case-based literature explores the messy complexities of teacher cooperation and collaboration. It points to the human, cultural, and political dimensions in schools that prevent changes in the organizational conditions of teachers’ work from achieving their anticipated outcomes. This article deepens this vein of research by examining the experiences of those who work in a school system where, because of its governance and curriculum organization, teachers must work in a professional environment which provides few opportunities for isolation or privacy. Drawing on a series of narrative inquiries into the work and lives of Jewish day school teachers, the article helps clarify different impulses behind the search for teacher community: those that derive from professional concerns, such as the goal to improve student achievement, and those that derive from personal concerns, such as the desire to belong or to experience fellowship in the workplace. In its final section, the article brings into view sources of teachers’ ambivalence about collaboration often overlooked in the school reform literature.
Altered cortical-amygdala coupling in social anxiety disorder during the anticipation of giving a public speech

Background Severe stress in social situations is a core symptom of social anxiety disorder (SAD). Connectivity between the amygdala and cortical regions is thought to be important for emotion regulation, a function that is compromised in SAD. However, it has never been tested if and how this connectivity pattern changes under conditions of stress-inducing social evaluative threat. Here we investigate changes in cortical-amygdala coupling in SAD during the anticipation of giving a public speech. Method Twenty individuals with SAD and age-, gender- and education-matched controls (n = 20) participated in this study. During the functional magnetic resonance imaging (fMRI) session, participants underwent three ‘resting-state’ fMRI scans: one before, one during, and one after the anticipation of giving a public speech. Functional connectivity between cortical emotion regulation regions and the amygdala was investigated. Results Compared to controls, SAD participants showed reduced functional integration between cortical emotion regulation regions and the amygdala during the public speech anticipation. Moreover, in SAD participants cortical-amygdala connectivity changes correlated with social anxiety symptom severity. Conclusions The distinctive pattern of cortical-amygdala connectivity suggests less effective cortical-subcortical communication during social stress-provoking situations in SAD.
MicroRNA-21: A Positive Regulator for Optimal Production of Type I and Type III Interferon by Plasmacytoid Dendritic Cells

Plasmacytoid dendritic cells (pDCs) are the major producers of type I and type III interferons (IFNs) that play essential roles in host antiviral immunity. MicroRNAs (miRs) are small, noncoding RNAs that can modulate many immune processes. Although molecular regulation of type I IFN production by pDCs has been studied extensively, the regulation of type III IFN production has not been studied thoroughly, particularly at posttranscriptional level. We show here that miR-21 is an essential positive regulator for the production of both IFN-α and IFN-λ by pDCs and for promoting host defense against viral infection. miR-21 was markedly upregulated in toll-like receptor (TLR)-activated pDCs and was crucial for TLR7/9 ligand- or herpesvirus-induced production of IFN-α and IFN-λ by pDCs. miR-21-deficient pDCs produced significantly lower levels of IFN-α and IFN-λ on activation than those by wild-type pDCs. Impaired antiviral immune responses were also observed in miR-21-deficient mice. Mechanistically, we identified phosphatase and tensin homolog (PTEN) as the major target of miR-21 in pDCs, and miR-21 deficiency resulted in increased expression of PTEN that suppressed TLR-mediated activation of PI3K-Akt-mTOR signaling in pDCs. Hence, our findings provide evidence that miR-21 positively regulates both IFN-α and IFN-λ production and identify an important role for miR-21 in regulating the function of pDCs and in host antiviral immunity.
Secure communication over radio channels

We study the problem of secure communication in a multi-channel, single-hop radio network with a malicious adversary that can cause collisions and spoof messages. We assume no pre-shared secrets or trusted-third-party infrastructure. The main contribution of this paper is f-AME: a randomized (f)ast-(A)uthenticated (M)essage (E)xchange protocol that enables nodes to exchange messages in a reliable and authenticated manner. It runs in O(|E|t2 log n) time and has optimal resilience to disruption, where E is the set of pairs of nodes that need to swap messages, n is the total number of nodes, C the number of channels, and t < C the number of channels on which the adversary can participate in each round. We show how to use f-AME to establish a shared secret group key, which can be used to implement a secure, reliable and authenticated long-lived communication service. The resulting service requires O(nt3 log n) rounds for the setup phase, and O(t log n) rounds for an arbitrary pair to communicate. By contrast, existing solutions rely on pre-shared secrets, trusted third-party infrastructure, and/or the assumption that all interference is non-malicious.
Ad Hoc Routing Protocol Performance in a Realistic Environment

Multiple wireless devices jointly create and maintain ad hoc networks; their employment is favored to happen in a variety of environments with distinct topological characteristics. Diversified environmental conditions are expected to vary network performance. In fact, obstacles, buildings and/or mountains may act as either barriers, or source of noise for the radio signals. Nevertheless, most of the previous performance evaluation studies based on simulation, neglected this consideration; they used simulation models that were too simplistic, and too narrow (i.e. idealistic) in their scopes. With this paper we propose a new, complete and realistic Urban Mobility Model (UMM). It models realistically users motion, and radio signals propagation in a citylike scenario. Our aim is to study the effects of realistic network simulation on routing performance. The results prove that a realistic scenario with roads and buildings has a significant impact on routing.
Applying Feature Selection to Software Defect Prediction Using Multi-objective Optimization

Software defect prediction can identify potential defective modules in advance and then provide guidances for software testers to allocate more testing resources on these modules. During the gathering process for defect prediction datasets, if multiple metrics are used to measure the program modules, it will result in curse of dimensionality. Feature selection is one of effective methods to alleviate this problem. However, designing effective feature selection methods is a great challenge. Motivated by the idea of search based software engineering, we formalize this problem as a multi-objective optimization problem, and then propose novel method MOFES. To verify the effectiveness of our proposed method, we choose PROMISE dataset gathered from real projects, and compare MOFES with some classical baseline methods. Final results show that our method has the advantages of selecting less features and achieving better prediction performance in most projects while its computational cost is acceptable.
Stability of Thalamocortical Synaptic Transmission across Awake Brain States

Sensory cortical neurons are highly sensitive to brain state, with many neurons showing changes in spatial and/or temporal response properties and some neurons becoming virtually unresponsive when subjects are not alert. Although some of these changes are undoubtedly attributable to state-related filtering at the thalamic level, another likely source of such effects is the thalamocortical (TC) synapse, where activation of nicotinic receptors on TC terminals have been shown to enhance synaptic transmission in vitro. However, monosynaptic TC synaptic transmission has not been directly examined during different states of alertness. Here, in awake rabbits that shifted between alert and non-alert EEG states, we examined the monosynaptic TC responses and short-term synaptic dynamics generated by spontaneous impulses of single visual and somatosensory TC neurons. We did this using spike-triggered current source-density analysis, an approach that enables assessment of monosynaptic extracellular currents generated in different cortical layers by impulses of single TC afferents. Spontaneous firing rates of TC neurons were higher, and burst rates were much lower in the alert state. However, we found no state-related changes in the amplitude of monosynaptic TC responses when TC spikes with similar preceding interspike interval were compared. Moreover, the relationship between the preceding interspike interval of the TC spike and postsynaptic response amplitude was not influenced by state. These data indicate that TC synaptic transmission and dynamics are highly conserved across different states of alertness and that observed state-related changes in receptive field properties that occur at the cortical level result from other mechanisms.
Masked inherited primary arrhythmia syndromes in sudden cardiac death patients accompanied by coronary vasospasm

Background/Aims Coronary vasospasms are one of the important causes of sudden cardiac death (SCD). Provocation of coronary vasospasms can be useful, though some results may lead to false positives, with patients potentially experiencing recurrent SCD despite appropriate medical treatments. We hypothesized that it is not coronary vasospasms but inherited primary arrhythmia syndromes (IPAS) that underlie the development of SCD. Methods We analyzed 74 consecutive patients (3.8%) who survived out-of-hospital cardiac arrest among 1,986 patients who had angiographically proven coronary vasospasms. Electrical abnormalities were evaluated in serial follow-up electrocardiograms (ECGs) during and after the index event for a 3.9 years median follow-up. Major clinical events were defined as the composite of death and recurrent SCD events. Results Forty five patients (60.8%) displayed electrocardiographic abnormalities suggesting IPAS: Brugada type patterns in six (8.2%), arrhythmogenic right ventricular dysplasia patterns in three (4.1%), long QT syndrome pattern in one (2.2%), and early repolarization in 38 (51.4%). Patients having major clinical events showed more frequent Brugada type patterns, early repolarization, and more diffuse multivessel coronary vasospasms. Brugada type pattern ECGs (adjusted hazard ratio [HR], 4.22; 95% confidence interval [CI], 1.16 to 15.99; p = 0.034), and early repolarization (HR, 2.97; 95% CI, 1.09 to 8.10; p = 0.034) were ultimately associated with an increased risk of mortality. Conclusions Even though a number of aborted SCD survivors have coronary vasospasms, some also have IPAS, which has the potential to cause SCD. Therefore, meticulous evaluations and follow-ups for IPAS are required in those patients.
A Distinctive Novel Epitheliomesenchymal Biphasic Tumor of the Stomach in Young Adults (“Gastroblastoma”): A Series of 3 Cases

This report describes 3 cases of a distinctive, hitherto unreported gastric epitheliomesenchymal biphasic tumor that differs from other biphasic tumors of the stomach and elsewhere: carcinosarcoma, biphasic synovial sarcoma, teratoma, and mixed tumor. The tumors occurred in young adults, 2 males and 1 female, of ages 19, 27, and 30 years. Two tumors were located in the greater curvature in the gastric body and one in the antrum. The tumors measured 5, 6, and 15 cm in maximum diameter, and their mitotic rates were 0, 4, and 30 mitoses per 50 HPF. There were 2 components: uniform oval or spindled cells in diffuse sheets, and clusters or cords of epithelial cells occasionally forming glandular structures with small lumens. The epithelial elements were positive for keratin cocktail AE1/AE3, keratin 18, and partly for keratin 7, but were negative for keratins 5/6, 20 and epithelial membrane antigen. The spindle cells were positive for vimentin and CD10. All components were negative for CD34, CD99, estrogen receptor, KIT, smooth muscle actin, desmin S100 protein, p63, calretinin, chromogranin, synaptophysin, CDX2, and thyroid transcription factor 1. In situ hybridization for SS18 rearrangement was negative in all cases separating this tumor from synovial sarcoma. All 3 patients were alive after follow-up of 3.5, 5, and 14 years. Because these tumors have some resemblance to blastomas of other organs, we propose the term “gastroblastoma” for this distinctive, at least low-grade malignant epitheliomesenchymal tumor of the stomach.
Sequence Analysis Using Logic Regression

Logic Regression is a new adaptive regression methodology that attempts to construct predictors as Boolean combinations of (binary) covariates. In this paper we use this algorithm to deal with single‐nucleotide polymorphism (SNP) sequence data. The predictors that are found are interpretable as risk factors of the disease. Significance of these risk factors is assessed using techniques like cross‐validation, permutation tests, and independent test sets. These model selection techniques remain valid when data is dependent, as is the case for the family data used here. In our analysis of the Genetic Analysis Workshop 12 data we identify the exact locations of mutations on gene 1 and gene 6 and a number of mutations on gene 2 that are associated with the affected status, without selecting any false positives. © 2001 Wiley‐Liss, Inc.
Packet Throughput Analysis of Static and Dynamic TDD in Small Cell Networks

We develop an analytical framework for the performance comparison of small cell networks operating under static time division duplexing (S-TDD) and dynamic TDD (D-TDD). By leveraging stochastic geometry and queuing theory, we derive closed-form expressions for the uplink (UL) and downlink (DL) packet throughput, also capturing the impact of random traffic arrivals and packet retransmissions. Through our analysis, we confirm that: 1) the number of scheduled user equipment may strongly affect the network throughput and 2) D-TDD outperforms S-TDD in DL, with the vice versa occurring in UL, since asymmetric transmissions reduce DL interference at the expense of an increased UL interference. We also find that in asymmetric scenarios, where most of the traffic is in DL, D-TDD provides a DL packet throughput gain by better controlling the queuing delay, and that such gain vanishes in the light-traffic regime.
Feeding rates of Balloniscus sellowii (Crustacea, Isopoda, Oniscidea): the effect of leaf litter decomposition and its relation to the phenolic and flavonoid content

Abstract The goal of this study was to compare the feeding rates of Balloniscus sellowii on leaves of different decomposition stages according to their phenolic and flavonoid content. Leaves from the visually most abundant plants were offered to isopods collected from the same source site. Schinus terebinthifolius,the plant species consumed at the highest rate, was used to verify feeding rates at different decomposition stages. Green leaves were left to decompose for one, two, or three months, and then were offered to isopods. The total phenolic and flavonoid contents were determined for all decomposition stages. Consumption and egestion rates increased throughout decomposition, were highest for two-month-old leaves, and decreased again in the third month. The assimilation rate was highest for green leaves. The mode time of passage through the gut was two hours for all treatments. Ingestion of leaves occurred after two or three days for green leaves, and on the same day for one-, two- and three-month-old leaves. The speed of passage of leaves with different decomposition stages through the gut does not differ significantly when animals are fed continuously. However, it is possible that the amount retained in the gut during starvation differs depending on food quality. The digestibility value was corrected using a second food source to empty the gut of previously ingested food, so that all of the food from the experiment was egested. The digestibility value was highest for green leaves, whereas it was approximately 20% for all other stages. This was expected given that digestibility declines during decomposition as the metabolite content of the leaves decreases. The phenolic content was highest in the green leaves and lowest in three-month-old leaves. The flavonoid content was highest in green leaves and lowest after two months of decomposition. Animals ingested more phenolics when consumption was highest. The estimated amount of ingested flavonoids followed the same trend as assimilation rate. Flavonoids accounted for a large portion of total phenolics, and the estimated amount of flavonoids consumed was similar for one-, two- and three-month-old leaves. Our results suggest that the high phenolic and flavonoid concentrations in green leaves are feeding deterrents. Isopods may discriminate among concentrations of flavonoids and modify their consumption rates to maintain their intake of flavonoids when ingesting leaves with lower flavonoid content.