Miracle-dz/UniFAR-FTUs huggingface dataset:
Computational study of growth and remodelling in the aortic arch

Opening angles (OAs) are associated with growth and remodelling in arteries. One curiosity has been the relatively large OAs found in the aortic arch of some animals. Here, we use computational models to explore the reasons behind this phenomenon. The artery is assumed to contain a smooth muscle/collagen phase and an elastin phase. In the models, growth and remodelling of smooth muscle/collagen depends on wall stress and fluid shear stress. Remodelling of elastin, which normally turns over very slowly, is neglected. The results indicate that OAs generally increase with longitudinal curvature (torus model), earlier elastin production during development, and decreased wall stiffness. Correlating these results with available experimental data suggests that all of these effects may contribute to the large OAs in the aortic arch. The models also suggest that the slow turnover rate of elastin limits longitudinal growth. These results should promote increased understanding of the causes of residual stress in arteries.
Emergence of chemoresistance in a metastatic basal cell carcinoma patient after complete response to hedgehog pathway inhibitor vismodegib (GDC‐0449)

Vismodegib (GDC‐0449, Genentech, USA), a small molecule inhibitor of the Hedgehog signalling pathway, has potent anti‐tumour activity in advanced basal cell carcinoma (BCC). We report a case of a 67‐year‐old Australian man with metastatic BCC including pulmonary disease with malignant effusion who showed a dramatic complete response to vismodegib but subsequently experienced a recurrence of pulmonary disease, indicative of chemoresistance to vismodegib. This case is the first to illustrate chemoresistance in a patient with metastatic BCC, and demonstrates the need for closely monitoring metastatic BCC patients even after an apparently complete response.
Logistic regression analysis of psychosocial correlates associated with recovery from schizophrenia in a Chinese community

Background and Aims: More mental health services are adopting the recovery paradigm. This study adds to prior research by (a) using measures of stages of recovery and elements of recovery that were designed and validated in a non-Western, Chinese culture and (b) testing which demographic factors predict advanced recovery and whether placing importance on certain elements predicts advanced recovery. Method: We examined recovery and factors associated with recovery among 75 Hong Kong adults who were diagnosed with schizophrenia and assessed to be in clinical remission. Data were collected on socio-demographic factors, recovery stages and elements associated with recovery. Logistic regression analysis was used to identify variables that could best predict stages of recovery. Receiver operating characteristic curves were used to detect the classification accuracy of the model (i.e. rates of correct classification of stages of recovery). Results: Logistic regression results indicated that stages of recovery could be distinguished with reasonable accuracy for Stage 3 (‘living with disability’, classification accuracy = 75.45%) and Stage 4 (‘living beyond disability’, classification accuracy = 75.50%). However, there was no sufficient information to predict Combined Stages 1 and 2 (‘overwhelmed by disability’ and ‘struggling with disability’). It was found that having a meaningful role and age were the most important differentiators of recovery stage. Conclusion: Preliminary findings suggest that adopting salient life roles personally is important to recovery and that this component should be incorporated into mental health services.
A Tale of Three Schools: Insights on Autocorrelations of Short Horizon Stock Returns

This article reexamines the autocorrelation patterns of short-horizon stock returns. We document empirical results which imply that these autocorrelations have been overstated in the existing literature. Based on several new insights, we provide support for a market efficiency-based explanation of the evidence. Our analysis suggests that institutional factors are the most likely source of the autocorrelation patterns. Article published by Oxford University Press on behalf of the Society for Financial Studies in its journal, The Review of Financial Studies.
People's experience and facts of changing climate: impacts and responses

Purpose – This paper aims to explore the local knowledge on climate change, its impacts and the responses they are making at the household or community level to deal with the changes on the basis of their experiences and perceptions. Design/methodology/approach – The study was based on household survey conducted with one male and one female respondent in 202 households. Alongside, series of focused group discussions were conducted with local people to capture the perception on about climate change, its impacts and adaptation strategies applied to enhance their resilience capacity to changing climate. Rainfall and temperature data were collected from Department of Hydrology and Meteorology (DHM) for seven and four different stations, respectively, within Kathmandu Valley and analyzed to understand the climatic trend. Findings – The perception of most of the local people on changes in temperature was almost in line with the recorded long-term climatic trend both showing an increasing trend, whereas the perc.
Evaluating alternative cannabis regimes

Background Cannabis policy continues to be controversial in North America, Europe and Australia. Aims To inform this debate, we examine alternative legal regimes for controlling cannabis availability and use. Method We review evidence on the effects of cannabis depenalisation in the USA, Australia and The Netherlands. We update and extend our previous (MacCoun & Reuter, 1997) empirical comparison of cannabis prevalence statistics in the USA, The Netherlands and other European nations. Results The available evidence indicates that depenalisation of the possession of small quantities of cannabis does not increase cannabis prevalence. The Dutch experience suggests that commercial promotion and sales may significantly increase cannabis prevalence. Conclusions Alternatives to an aggressively enforced cannabis prohibition are feasible and merit serious consideration. A model of depenalised possession and personal cultivation has many of the advantages of outright legalisation with few of its risks.
The Impact of Mandatory IFRS Adoption on Equity Valuation of Accounting Numbers for Security Investors in the EU

Motivated by the European Union (EU) decision to mandate application of the International Financial Reporting Standards (IFRS) to the consolidated financial statements of all EU listed firms (Regulation (EC) 1606/2002), starting in December 2005, we compare the value relevance of accounting information in 14 European countries in the year prior to and the year of the mandatory adoption of the IFRS. We focus on three accounting information items for which measurements under IFRS are likely to differ considerably from measurements under domestic accounting practices across the EU countries prior to the introduction of the international standards: goodwill, research and development expenses (R&D), and asset revaluation. These three items, selected on an a priori basis, have been shown in previous research to differ in the effect of uncertainty on their future benefits. We use valuation models that include these three variables and in addition the book value of equity and earnings. Overall, our study suggests that the adoption of the IFRS has increased the value relevance of the three accounting numbers for investors in equity securities in the EU. Association tests support our two hypotheses: (1) in the year prior to the mandatory adoption of the IFRS, the incremental value relevance to investors of the three domestic GAAP-based accounting items was greater in countries where the respective domestic standards were more compatible with the IFRS; and (2) the higher the deviation of the three domestic GAAP-based accounting items from their corresponding IFRS values, the greater the incremental value relevance to investors from the switch to IFRS. These associations prevail when considering cross-country differences in the institutional environments, which tend to provide complementary effects.
Octreotide for acute esophageal variceal bleeding: a meta-analysis.

BACKGROUND & AIMS Studies of octreotide have not demonstrated a consistent benefit in efficacy or safety compared with conventional therapies. This study statistically pooled existing trials to evaluate the safety and efficacy of octreotide for esophageal variceal hemorrhage. METHODS We identified randomized trials of octreotide for variceal hemorrhage from computerized databases, scientific meeting abstracts, and the manufacturer of octreotide. Blinded reviewers abstracted the data, and a meta-analysis was performed. RESULTS Octreotide improved control of esophageal variceal hemorrhage compared with all alternative therapies combined (relative risk [RR], 0.63; 95% confidence interval [CI], 0.51-0.77); vasopressin/terlipressin (RR, 0.58; 95% CI, 0.42-0.81); or no additional intervention/placebo (among patients that received initial sclerotherapy/banding before randomization) (RR, 0.46; 95% CI, 0.32-0.67). Octreotide had comparable efficacy to immediate sclerotherapy for control of bleeding (RR, 0.94; 95% CI, 0.55-1.62), fewer major complications than vasopressin/terlipessin (RR, 0.31; 95% CI, 0.11-0.87), and a complication profile comparable to no intervention/placebo (RR, 1.06; 95% CI, 0.72-1.55). No specific alternative therapy demonstrated a mortality benefit. CONCLUSIONS These results favor octreotide over vasopressin/terlipressin in the control of esophageal variceal bleeding and suggest it is a safe and effective adjunctive therapy after variceal obliteration techniques. Trials are needed to determine the optimal dose, route, and duration of octreotide treatment.
The Poverty of Nations: A Quantitative Exploration

We document regularities in the distribution of relative incomes and patterns of investment in countries and over time. We develop a quantitative version of the neoclassical growth model with a broad measure of capital in which investment decisions are affected by distortions. These distortions follow a stochastic process which is common to all countries. Our model generates a panel of outcomes which we compare to the data. In both the model and the data, there is greater mobility in relative incomes in the middle of the income distribution than at the extremes. The 10 fastest growing countries and the 10 slowest growing countries in the model have growth rates and investment-output ratios similar to those in the data. In both the model and the data, the `miracle' countries have nonmonotonic investment-output ratios over time. The main quantitative discrepancy between the model and the data is that there is more persistence in growth rates of relative incomes in the model than in the data.
Infection of cerebrospinal fluid shunts: causative pathogens, clinical features, and outcomes.

This retrospective chart review describes the clinical features, pathogens, and outcomes of 46 patients with cerebrospinal fluid (CSF) shunt infections collected over 16 years. The overall CSF shunt infection rate was 2.1%, broken down into 1.7 and 9.3% in adult and pediatric groups, respectively. Fever and progressive consciousness disturbance were the most clinical features in the adult patient group, whereas disturbance of consciousness and abdominal symptoms and signs were the two most common clinical features in the pediatric patient group. The most frequently isolated microorganisms were of the Staphylococcus spp. , including Staphylococcus aureus and coagulase negative Staphylococcus, which accounted for 47% of the episodes. Furthermore, increases in polymicrobial and Gram-negative bacilli infections were observed in our study. Due to the high proportion of oxacillin-resistant Staphylococcus spp. and polymicrobial infections, we recommend initial empirical antibiotics with both vancomycin and a third-generation cephalosporin for cases in which the causative bacteria has not been identified or for which the results of antimicrobial susceptibility tests are not available. For patients who develop smoldering fevers, progressive disturbed consciousness, seizures, or abdominal fullness after ventriculoperitoneal shunt procedures, CSF shunt infections should be suspected. Although some infections have been managed successfully with antimicrobial therapy alone, the timely use of appropriate antibiotics according to antimicrobial susceptibility testing and the removal of the shunt apparatus are essential for successful treatment.
Sector Differences in the Public Service Motivation–Job Satisfaction Relationship: Exploring the Role of Organizational Characteristics

Public service motivation (PSM) has a documented, positive effect on job satisfaction—especially in the public sector. However, organizational characteristics such as red tape, hierarchical authority, and the absence of organizational goal specificity, which are often more present in public sector organizations, may have negative influences on the PSM–job satisfaction relationship. This study explores the impact of these organizational characteristics on sector differences in the PSM–job satisfaction relationship in a “hard case” setting. Using survey data with low-level, white-collar employees, we confirm a positive PSM–job satisfaction association in the public sector compared with the private sector, where we see a negative association. Furthermore, perceived red tape and the absence of organizational goal specificity have negative influences on job satisfaction; nevertheless, sector differences remain in the PSM–job satisfaction relationship when controlled for these organizational characteristics. This suggests that public or private sector status is more important for the PSM–job satisfaction relationship than other organizational characteristics.
Tourist shopping preferences and expenditure behaviours: The case of the Taiwanese outbound market

Using data from the 1999 Survey of Taiwanese Outbound Travellers, this research quantitatively examined tourists’ shopping preferences and behaviours in relation to their socio-demographic characteristics and trip attributes. Results indicated that travel purpose, travel style, age and gender were significant factors influencing the amount of money travellers spent on shopping and the items that they preferred to buy. Such understanding affords destinations and retail businesses practical knowledge useful for destination marketing, product development, retail merchandising and customer service. Basic questions can be addressed more confidently, such as what the most popular items for a well-defined demographic group are, and what factors can be used to predict the spending level of tourist shoppers.
Total Factor Productivity Growth in Pakistan: An Analysis of the Agricultural and Manufacturing Sectors

This paper uses Cobb-Douglas and translog production functions to calculate total factor productivity (TFP) in Pakistan over the period 1985 – 2005, first for the manufacturing and agricultural sectors individually, then for the economy as a whole. Inmanufacturing, productivity increased at an average of 2.4% per year with output growth being driven mainly by increases in capital. Despite the limitations of the available agricultural data, we have determined that productivity has grown at an average rate of 1.75% per year in this sector. The major drivers of growth in agriculture have been increases in labor and TFP.These estimates of sectoral TFP put Pakistan at par or above average as compared to other developing countries, but lagging behind the East Asian economies. For the economy as a whole, TFP has increased at an average rate of only 1.1% a year in Pakistan, resulting in almost three quarters of GDP growth attributed to increases in labor and the capital stock.
Indian farmers' experience with and perceptions of organic farming

Abstract In India, the number of farmers converting to organic farming has increased in the recent past despite the lack of government support in providing knowledge and extension to the farmers. The aim of this article is to investigate the perceived relevance, benefits and barriers to a conversion to organic agriculture in three different Indian contexts—in Tamil Nadu, Madhya Pradesh and Uttarakhand states. In each state, 40 farmers from both organic and conventional systems were interviewed. The findings indicated that conventional producers identified production and marketing barriers as the main constraints to adopting organic farming, while the age and education of the farmer were not deemed a problem. Lack of knowledge and lack of institutional support were other barriers to conversion. Some farmers were, however, interested in converting to organic farming in the near future in Madhya Pradesh due to the low cost of production, and in Tamil Nadu and Uttarakhand due to the price premium and health benefits. On the other hand, organic farmers were more concerned with health, environmental and production factors when institutional support was available. The years under conversion were positively associated with reduced input costs in all three states and with increased income in Tamil Nadu and increased yield in Madhya Pradesh. Both organic and conventional farmers found the two production factors, low yield and pest control, to be of major concern. However, organic farms in Madhya Pradesh and Uttarakhand experienced yield increases because most of the farms were in the post-conversion period, while the farms in Tamil Nadu were in the conversion period and experienced yield reduction. The study suggests that the government scheme for compensating yield loss during the conversion period and a price premium may help farmers adopt organic agriculture on a large scale in India.
Bone loss in patients with rheumatoid arthritis: results from a population-based cohort of 366 patients followed up for two years.

OBJECTIVE To evaluate the extent of and risk factors for bone loss in a population-based cohort of patients with rheumatoid arthritis (RA) receiving conventional health care. METHODS In a longitudinal study, clinical data were collected and bone mineral density (BMD) measurements were performed at baseline and after 2 years. Dual-energy x-ray absorptiometry was used for hip and spine BMD measurements. At baseline, patients received advice about lifestyle adjustments and calcium and vitamin D supplementation; during the followup period they were treated with antirheumatic and bone-sparing drugs, according to clinical judgment. RESULTS After a mean +/- SD of 2.2 +/- 0.2 years, 366 (298 women, 68 men) of the 488 patients who were examined at baseline were reexamined. At that time, 47.9% were current users of corticosteroids and 37.0% were using antiresorptive drugs (hormone replacement therapy, bisphosphonates, or calcitonin). The mean BMD reduction was -0.64% in the femoral neck, -0.77% in the total hip, and -0.29% in the spine at L2-4. BMD was increased at all measurement sites in current users of antiresorptive drugs (0.16-1.64%) but was decreased in patients using calcium and vitamin D alone (-1.99% to -1.39%) and in patients not using any osteoporosis treatment (-1.20% to -0.43%). Current use of corticosteroids was independently associated with increased risk for BMD loss in the total hip (odds ratio [OR] 2.63, 95% confidence interval [95% CI] 1.38-5.00) and spine at L2-4 (OR 2.70, 95% CI 1.30-5.63), whereas current use of antiresorptive drugs was associated with decreased risk for bone loss in the total hip (OR 0.43, 95% CI 0.20-0.89). CONCLUSION Results of this population-based, 2-year followup study indicate that adequate management of patients with RA, addressing both the rheumatic disease and osteoporosis, protects against bone loss.
Exploring the discharge of e-countability by charities

Purpose - – This research explores the use of the internet, a mechanism that provides the opportunity to reach vast audiences efficiently and cost effectively, by United Kingdom (UK) charities to discharge accountability. Design/methodology/approach - – This research combines a content analysis of the web sites of large UK charities and semi-structured interviews with key charity personnel responsible for the formulation and dissemination of information to stakeholders. Findings - – The results indicate that, in most cases, charity web sites, as accountability mechanisms, appear to play a wide role, being directed at both upward and downward stakeholders. However, while the web sites are usually professionally created with appropriate web site presentation and page design, the discharge of fiduciary accountability via the internet is not universal. Research limitations/implications - – This research focuses on large UK charities. This, together with the nature of the items captured by the content analysis checklist and the semi-structured interviews, inevitably affects its generalisability. Practical implications - – Accepting that charities have a duty to account to their stakeholders, and that the input of accounting practitioners is vital in this process, this research extends our understanding of how the internet is employed by charities to fulfil this duty. Originality/value - – The charity sector has grown extensively in size and prominence in recent years and policymakers have come to embrace the role that charities play in societal development. This paper provides a crucial insight into the discharge of accountability by charities through the internet.
German cultural policy: An overview

The most important aspect of cultural policy in Germany is its federally devolved nature. Hence the article begins with an examination of the different levels of cultural policy, from the all-important municipal authorities to the relatively autonomous regional government and, finally, the national government, which discharges certain responsibilities in cultural matters through a number of departments, including the recently created ministry of culture. Certain exemplary structures of coordination in the cultural sphere are examined in some detail and the major phases in the development of German cultural policy since 1945 outlined. Discussion then focuses on selected case studies of cultural policy since the unification of Germany in 1990, reflecting the federal, municipal and regional levels of policy-making. The concluding section considers some of the advantages and disadvantages of the German model with its hugely expensive commitment to the importance of culture.
VOLUNTARY DISCLOSURE OF ACCOUNTING RATIOS IN THE UK

Abstract This paper investigates whether the voluntary disclosure of ratios in corporate annual reports can be explained by agency and signalling theory. The two theories are discussed and the applicability to explaining ratio disclosures considered. Drawing on agency and signalling theory, seven hypotheses are tested using data collected over five years, for 313 UK companies. More specifically, associations are considered between ratio disclosure and the following characteristics: company profitability; return on investment; gearing; liquidity; company efficiency; size and industry. The paper finds some evidence of an association between ratio disclosure and company performance, size and industry. The implications of these findings are considered and areas of further research discussed.