Miracle-dz/UniFAR-FTUs huggingface dataset:
Imaging language networks before and after anterior temporal lobe resection: Results of a longitudinal fMRI study

Purpose: Anterior temporal lobe resection (ATLR) controls seizures in up to 70% of patients with intractable temporal lobe epilepsy (TLE) but, in the language dominant hemisphere, may impair language function, particularly naming. Functional reorganization can occur within the ipsilateral and contralateral hemispheres. We investigated reorganization of language in left‐hemisphere–dominant patients before and after ATLR; whether preoperative functional magnetic resonance imaging (fMRI) predicts postoperative naming decline; and efficiency of postoperative language networks.
Toward Cancer Therapy in Carcinomas Glucocorticoid Cotreatment Induces Apoptosis Resistance Updated Version Cited Articles Citing Articles E-mail Alerts Glucocorticoid Cotreatment Induces Apoptosis Resistance toward Cancer Therapy in Carcinomas 1

Chemotherapy and radiation therapy for cancer often have severe side effects that limit their efficacy. Glucocorticoids (GCs) are frequently used as cotreatment because they may have potent proapoptotic properties and reduce nausea, hyperemesis, and acute toxicity on normal tissue. In contrast to the proapoptotic effect of GCs in lymphoid cells, resistance toward cancer therapy-mediated apoptosis was induced in solid tumors of human cervix and lung carcinomas. Filter hybridization, expression data, as well as functional assays identified multiple core apoptosis molecules, which are regulated by GCs in a pro-or antiapoptotic manner. Both antiapo-ptotic genes such as FLIP and members of the Bcl-2 and IAP family as well as proapoptotic elements of the death receptor and mitochondrial apoptosis pathways were down-regulated in carcinomas resulting in a decreased activity of caspase-8, caspase-9, and caspase-3. In contrast, death receptor and mitochondrial apoptosis signaling as well as caspase activity was enhanced by dexamethasone in lymphoid cells. To restore apoptosis sensitivity in dexamethasone-treated carcinomas, caspase-8 and caspase-9 were transfected. This resensitized tumor cells in vitro and xenografts in vivo to cisplatin induced cell death. These data therefore raise concern about the widespread combined use of GCs with antineo-plastic drugs or agents in the clinical management of cancer patients.
DNA adduct levels associated with p53 induction and delay of MCF‐7 cells in S phase after exposure to benzo[g]chrysene dihydrodiol epoxide enantiomers

Optically active isomers of a mammary carcinogen, anti‐benzo[g]chrysene 11,12‐dihydrodiol 13,14‐epoxide, react to different extents with DNA and generate DNA adducts that differ in their stereochemistry. In the study reported here, the effect of these two enantiomers on the progress of human breast carcinoma MCF‐7 cells through the cell cycle was investigated. Each enantiomer caused the cells to accumulate in the S phase, but a higher dose of the benzo[g]chrysene 11S,12R‐dihydrodiol 13R,14S‐epoxide than of its enantiomer was required to induce this effect. Similarly, induction of p53 also required a higher dose of benzo[g]chrysene 11S,12R‐dihydrodiol 13R,14S‐epoxide. Postlabeling studies indicated that the latter enantiomer also caused less modification of MCF‐7 cell DNA for a given level of exposure than did benzo[g]chrysene 11R,12S‐dihydrodiol 13S,14R‐epoxide. These results suggest that p53 induction and delay in the S phase are similarly related to DNA binding and that a level of binding of the order of 1 adduct per 105 nucleotides is associated with these effects. Mol. Carcinog. 23:115–120, 1998. © 1998 Wiley‐Liss, Inc.
Proximity neighbor selection for a DHT in wireless multi-hop networks

A mobile ad hoc network (MANET) is a multi-hop wireless network having no infrastructure. Thus, the mobile nodes have to perform basic control tasks, such as routing, and higher-level tasks, such as service discovery, in a cooperative and distributed way. Originally conceived as a peer-to-peer application for the Internet, distributed hash tables (DHTs) are data structures offering both, scalable routing and a convenient abstraction for the design of applications in large, dynamic networks. Hence, DHTs and MANETs seem to be a good match, and both have to cope with dynamic, self-organizing networks. DHTs form a virtual control structure oblivious to the underlying network. Several techniques to improve the performance of DHTs in wired networks have been established in the literature. A particularly efficient one is proximity neighbor selection (PNS). PNS has to continuously adapt the virtual network to the physical network, incurring control traffic. The applicability of PNS and DHTs for MANETs commonly is regarded as hard because of this control traffic, the complexity of the adaptation algorithms, and the dynamics of a MANET. Using simulations supported by analytical methods, we show that by making a minor addition to PNS, it is also applicable for MANETs. We additionally show that the specifics of a MANET make PNS an easy exercise there. Thus, DHTs deliver good performance in MANETs.
Evolution of Conduit Geometry and Eruptive Parameters During Effusive Events

The dynamics of effusive events is controlled by the interplay between conduit geometry and source conditions. Dyke‐like geometries have been traditionally assumed for describing conduits during effusive eruptions, but their depth‐dependent and temporal modifications are largely unknown. We present a novel model which describes the evolution of conduit geometry during effusive eruptions by using a quasi steady state approach based on a 1‐D conduit model and appropriate criteria for describing fluid shear stress and elastic deformation. This approach provides time‐dependent trends for effusion rate, conduit geometry, exit velocity, and gas flow. Fluid shear stress leads to upward widening conduits, whereas elastic deformation becomes relevant only during final phases of effusive eruptions. Simulations can reproduce different trends of effusion rate, showing the effect of magma source conditions and country rock properties on the eruptive dynamics. This model can be potentially applied for data inversion in order to study specific case studies.
Home is where sleep is: an ecological approach to test the validity of actigraphy for the assessment of insomnia.

STUDY OBJECTIVES This study tested the ecological validity of actigraphy (ACT) for estimating objective sleep parameters in participants' homes. We also examined how well ACT and polysomnography (PSG) measures discriminated (1) individuals with and without insomnia; and (2) nights participants rated worse, the same as, or better than average. METHODS Thirty-one primary insomnia sufferers and 31 normal sleepers completed up to 3 consecutive monitoring nights with wrist ACT and PSG in their homes. They also rated how each night compared to their "average night's" sleep. ACT and PSG measures of sleep onset latency (SOL), wake after sleep onset (WASO), total sleep time (TST), and sleep efficiency (SE) were then compared using Bland and Altman correlational procedures and repeated measures ANOVAs. Differences between groups and among nights assigned distinctive ratings were tested via mixed-model ANOVAs. RESULTS Medium to large between- and within-subject correlations were observed for all measures in the insomnia sufferers sample and for most measures in the normal sleepers sample. Two (ACT vs. PSG) x 3 (nights) repeated measures ANOVAs showed that, in both samples, SOL derived from ACT was consistently lower than SOL derived from PSG across the 3 nights of recording. By contrast, ACT and PSG produced estimates of WASO, TST, and SE that did not differ from each other across nights. Subsequent 2 (insomnia vs. normal sleeper) x 3 (worse, same, better than average) mixed-model ANOVAs showed only ACT SOL discriminated those with and without insomnia and nights assigned distinctive ratings. Among the PSG-derived measures, only SE showed such a pattern. CONCLUSIONS ACT provides informative data for insomnia sufferers and normal sleepers in their usual sleep environments. The ACT estimate of SOL seems sensitive to night-to-night differences in subjective sleep ratings. A possible strength of ACT lies in its assessment of nocturnal movement, a parameter different from PSG-based sleep measures.
Investigating survival prognosis of glioblastoma using evolutional properties of gene networks

In recent years, there has been widespread interest and a large number of publications on the application of graph theory techniques into constructing and analyzing biologically-informed gene networks from cancer cell line data sets. Current research efforts have predominantly looked at an overall static, topological, representation of the network, and have not investigated the application of graph theoretical techniques to evolutionary investigations of cancer. A number of these studies have used graph theory metrics, such as degree, betweenness, and closeness centrality, to identify important hub genes in these networks. However, these have not fully investigated the importance of genes across the different stages of the disease. Previous human glioblastoma publications have identified four subtypes of glioblastoma in adults, based on signature genes. In one such publication, Verhaak et al. found that the subtypes correspond to a narrow median survival range, from 11.3 months for the most aggressive subtype, to 13.1 months for the least aggressive one. In this work, we present an evolutionary graph theory study of glioblastoma based on survival data categorization, confirming genes associated with different survival times identified using established graph theory metrics. The work is extending the application of graph theory approaches to evolutionary studies of cancer cell line data.
On generalized semi-bent (and partially bent) Boolean functions

In this paper, we obtain a characterization of generalized Boolean functions based on spectral analysis. We investigate a relationship between the Walsh-Hadamard spectrum and f , the sum-of-squares-modulus indicator (SSMI) of the generalized Boolean function. It is demonstrated that f = 2 2n+s for every s-plateaued generalized Boolean function in n variables. Two classes of generalized semi-bent Boolean functions are constructed.We have constructed a class of generalized semi-bent functions in (n + 1) variables from generalized semi-bent functions in n variables and identify a subclass of it for which f and4 f both have optimal value. Finally, some construction on generalized partially bent Boolean functions are given.
Efficient pattern discovery for semistructured data

The process of discovering frequent patterns from large semistructured data repositories is one of the hardest categories of tree mining problems, since it involves the discovery of unordered embedded tree patterns. Existing work has focused primarily on the discovery of ordered, induced trees. This work proposes a divide-and-conquer algorithm called WTIMiner to discover the complete set of frequent unordered embedded subtrees. The algorithm successfully reduces the complexity of pattern matching and counting problem that a regular tree mining algorithm faces. Experimental results demonstrate the efficiency and scalability of WTIMiner in terms of both time and space
Does goal-directed haemodynamic and fluid therapy improve peri-operative outcomes?: A systematic review and meta-analysis

BACKGROUND Much uncertainty exists as to whether peri-operative goal-directed therapy is of benefit. OBJECTIVES To discover if peri-operative goal-directed therapy decreases mortality and morbidity in adult surgical patients. DESIGN An updated systematic review and random effects meta-analysis of randomised controlled trials. DATA SOURCES Medline, Embase and the Cochrane Library were searched up to 31 December 2016. ELIGIBILITY CRITERIA Randomised controlled trials enrolling adult surgical patients allocated to receive goal-directed therapy or standard care were eligible for inclusion. Trauma patients and parturients were excluded. Goal-directed therapy was defined as fluid and/or vasopressor therapy titrated to haemodynamic goals [e.g. cardiac output (CO)]. Outcomes included mortality, morbidity and hospital length of stay. Risk of bias was assessed using Cochrane methodology. RESULTS Ninety-five randomised trials (11 659 patients) were included. Only four studies were at low risk of bias. Modern goal-directed therapy reduced mortality compared with standard care [odds ratio (OR) 0.66; 95% confidence interval (CI) 0.50 to 0.87; number needed to treat = 59; N = 52; I2 = 0.0%]. In subgroup analysis, there was no mortality benefit for fluid-only goal-directed therapy, cardiac surgery patients or nonelective surgery. Contemporary goal-directed therapy also reduced pneumonia (OR 0.69; 95% CI, 0.51 to 0. 92; number needed to treat = 38), acute kidney injury (OR 0. 73; 95% CI, 0.58 to 0.92; number needed to treat = 29), wound infection (OR 0.48; 95% CI, 0.37 to 0.63; number needed to treat = 19) and hospital length of stay (days) (−0.90; 95% CI, −1.32 to −0.48; I2 = 81. 2%). No important differences in outcomes were found for the pulmonary artery catheter studies, after accounting for advances in the standard of care. CONCLUSION Peri-operative modern goal-directed therapy reduces morbidity and mortality. Importantly, the quality of evidence was low to very low (e.g. Grading of Recommendations, Assessment, Development and Evaluation scoring), and there was much clinical heterogeneity among the goal-directed therapy devices and protocols. Additional well designed and adequately powered trials on peri-operative goal-directed therapy are necessary.
Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation

Peripheral interactions between nociceptive fibers and mast cells contribute to inflammatory pain, but little is known about mechanisms mediating neuro-immune communication. Here we show that metalloproteinase MT5-MMP (MMP-24) is an essential mediator of peripheral thermal nociception and inflammatory hyperalgesia. We report that MT5-MMP is expressed by CGRP-containing peptidergic nociceptors in dorsal root ganglia and that Mmp24-deficient mice display enhanced sensitivity to noxious thermal stimuli under basal conditions. Consistently, mutant peptidergic sensory neurons hyperinnervate the skin, a phenotype that correlates with changes in the regulated cleavage of the cell-cell adhesion molecule N-cadherin. In contrast to basal nociception, Mmp24−/− mice do not develop thermal hyperalgesia during inflammation, a phenotype that appears associated with alterations in N-cadherin-mediated cell-cell interactions between mast cells and sensory fibers. Collectively, our findings demonstrate an essential role of MT5-MMP in the development of dermal neuro-immune synapses and suggest that this metalloproteinase may be a target for pain control.
The Usefulness of Computer-Based Information to Public Managers

This study uses data from 260 public managers to assess two broad images of the potential of information technology and computer-based information (CBI) to serve public managers: the "knowledge executive" and the "CBI consumer. " The data were collected as part of a longitudinal study of computer user in more than 40 U.S. cities conducted in 1976 and again in 1988. The results show that computer-based information is important for most managers, and many report they are extremely dependent upon it. Also, the managers currently find the information more valuable for control of financial resources than for management of operations. Furthermore, among four sets of factors that might account for differences in the usefulness of computer-based information to managers, quality and accessibility of the information and the manager's style of use are particularly important. Finally, managers who are most satisfied with the usefulness of computer-based information are those who use support staff to mediate their computer-based information environment, rather than those who use the computer to access information directly. Such indirect use of computing might be the most appropriate mode for many contemporary managers. Therefore, the focus of design efforts for information systems for managers should be as much on these intermediaries as on the executives themselves.
The Development of Musical Skills of Underprivileged Children Over the Course of 1 Year: A Study in the Context of an El Sistema-Inspired Program

Developmental research in music has typically centered on the study of single musical skills (e.g., singing, listening) and has been conducted with middle class children who learn music in schools and conservatories. Information on the musical development of children from different social strata, who are enrolled in community-based music programs, remains elusive. This study examined the development of musical skills in underprivileged children who were attending an El Sistema-inspired program in Los Angeles. We investigated how children, predominantly of Latino ethnicity, developed musically with respect to the following musical skills – pitch and rhythmic discrimination, pitch matching, singing a song from memory, and rhythmic entrainment – over the course of 1 year. Results suggested that participation in an El Sistema-inspired program affects children’s musical development in distinct ways; with pitch perception and production skills developing faster than rhythmic skills. Furthermore, children from the same ethnic and social background, who did not participate in the El Sistema-inspired music program, showed a decline in singing and pitch discrimination skills over the course of 1 year. Taken together, these results are consistent with the idea of musical development as a complex, spiraling and recursive process that is influenced by several factors including type of musical training. Implications for future research are outlined.
Activation of the coagulation cascade in C1-inhibitor deficiencies.

Activation of the contact and complement systems in C1-inhibitor deficiencies is thought to contribute to the pathogenesis of angioedema attacks by releasing kinins. Trigger stimuli of attacks may also activate coagulation. This is particularly important because experimental data suggest that thrombin, the main enzyme of the coagulation cascade, increases vascular permeability and can thus influence edema formation. We have studied 19 patients with hereditary angioedema (HAE) during remission, 5 HAE patients during acute attacks, and 6 patients with acquired angioedema (AAE) during remission and during seven attacks. Thirty normal subjects, matched for sex and age, served as controls. Generation of thrombin was measured by enzyme-linked immunosorbent assay (ELISA) as plasma levels of the prothrombin fragment 1 + 2 (F1 + 2); the initiators of the tissue factor and contact coagulation pathways were investigated by measuring plasma levels of activated factor VII (FVIIa) coagulometrically and activated factor XII (FXIIa) by ELISA. Cleavage of high molecular weight kininogen (HK) was evaluated by immunoblotting analysis. F1 + 2 was slightly increased during remission and further significantly increased during attacks in both HAE (P = .0115) and AAE. FVIIa and FXIIa, normal during remission, increased strikingly during attacks in both HAE (P = .0022 and P = .0044) and AAE. During remission, cleaved HK was normal in HAE and high in AAE; during attacks it increased in HAE (P = .0008) and remained elevated in AAE. Our data indicate that in C1-inhibitor deficient patients there is increased generation of thrombin during attacks, with signs of activation of both the contact and tissue factor coagulation pathways. In conclusion, C1-inhibitor deficiency, whether hereditary or acquired, has demonstrable activation of the coagulation and kinin-forming cascades during attacks and that thrombin should be considered a possible contributing factor in the pathogenesis of edema in HAE and AAE.
Endovascular repair of post-traumatic, concomitant popliteal artery pseudoaneurysm and arteriovenous fistula

Popliteal artery trauma is a potentially devastating injury to the lower extremity with substantial associated morbidity. Pseudoaneurysm and arteriovenous fistula formation are complications of arterial injury that often present in a delayed fashion. Although these have traditionally been repaired using an open procedure, the growth of minimally invasive techniques has provided new therapeutic options for the treatment of such lesions. The present report discusses the successful treatment of concomitant popliteal pseudoaneurysm and arteriovenous fistula after delayed presentation by placing covered stents endovascularly.
Tintinnides (Ciliophora, Oligotrichida, Tintinnina) de l'Atlantique boréal, de l'Océan Indien et de quelques mers adjacentes : Méditerranée, Mer Caraibe, Mer Rouge. Inventaire et distribution. Observations basées sur les loricas.

L'inventaire et la distribution des tintinnides, un des principaux groupes du zooplancton, ont pu etre effectues sur des echantillons de plancton provenant de diverses regions marines : dans l'Atlantique boreal occidental, du Labrador au Banc Georges, dans la Province caraibe et en Mer des Sargasses, dans l'Atlantique central, de l'ouest des Acores a la cote africaine, dans l'Atlantique oriental, en Manche, dans le Golfe de Gascogne et en Mediterranee, ainsi que dans l'Ocean Indien, depuis la Mer Rouge jusqu'a l'est-sud-est des iles Kerguelen, au niveau de la convergence antarctique. Les resultats acquis confirment, globalement, les observations anterieures sur la distribution de ces protozoaires, aussi connus pour leur grande variabilite morphologique intraspecifique. Le genre Tintinnopsis riche en especes logees dans une lorica agglutinee arenacee, a une distribution neritique ; la plupart des especes sont cotieres et remontent dans les estuaires jusqu’au niveau influence par les eaux marines. La nature de leur lorica parait etre une adaptation a la survie aussi bien a la face predation qu'a sa protection dans un milieu turbulent. C'est le genre le mieux represente dans les eaux cotieres francaises. Les especes oceaniques ont, generalement, une lorica hyaline et transparente, qui serait une adaptation pour echapper a la predation, c'est le cas des genres Eutintinnus, Rhabdonella. Petalotricha, Steenstrupiella, etc., qui frequentent egalement les eaux neritiques. Les observations confirment aussi la distribution panoceanique de la plupart des especes tropicales, la repartition des genres Parafavella et Ptychocylis dans les regions plutot septentrionales de l'hemisphere boreal, et celle du genre Cymatocylis, plutot dans les regions meridionales de l'hemisphere austral et, peut-etre l'endemisme de certaines especes.