Miracle-dz/UniFAR-FTUs huggingface dataset:
How hollow melanosomes affect iridescent colour production in birds

Developmental constraints and trade-offs can limit diversity, but organisms have repeatedly evolved morphological innovations that overcome these limits by expanding the range and functionality of traits. Iridescent colours in birds are commonly produced by melanin-containing organelles (melanosomes) organized into nanostructured arrays within feather barbules. Variation in array type (e.g. multilayers and photonic crystals, PCs) is known to have remarkable effects on plumage colour, but the optical consequences of variation in melanosome shape remain poorly understood. Here, we used a combination of spectrophotometric, experimental and theoretical methods to test how melanosome hollowness—a morphological innovation largely restricted to birds—affects feather colour. Optical analyses of hexagonal close-packed arrays of hollow melanosomes in two species, wild turkeys (Meleagris gallopavo) and violet-backed starlings (Cinnyricinclus leucogaster), indicated that they function as two-dimensional PCs. Incorporation of a larger dataset and optical modelling showed that, compared with solid melanosomes, hollow melanosomes allow birds to produce distinct colours with the same energetically favourable, close-packed configurations. These data suggest that a morphological novelty has, at least in part, allowed birds to achieve their vast morphological and colour diversity.
Clinical Outcomes and Safety of Transfemoral Aortic Valve Implantation Under General Versus Local Anesthesia: Subanalysis of the French Aortic National CoreValve and Edwards 2 Registry

Background—Transcatheter aortic valve implantation (TAVI) performed under local anesthesia (LA) is becoming increasingly common. We aimed to compare the clinical outcomes in patients who underwent transfemoral-TAVI under general anesthesia (GA) and LA. Methods and Results—Data from 2326 patients in the French Aortic National CoreValve and Edwards 2 (FRANCE 2) registry who underwent transfemoral-TAVI were analyzed. During the study period, the percentage of LA procedures increased gradually from 14% in January 2010 to 59% in October 2011. The clinical outcomes for GA (n=1377) and LA (n=949) were compared. Numerous baseline characteristics differed between the 2 groups, and the use of transesophageal echocardiographic guidance was more common in GA than in LA (76.3% versus 16.9%; P<0.001). Device success and cumulative 30-day survival rates were similar in the 2 groups (97.6% versus 97.0%; P=0.41 and 91.6% versus 91.3%; P=0.69, respectively), whereas the incidence of postprocedural aortic regurgitation≥mild was significantly lower in GA than in LA (15.0% versus 19.1%; P=0.015). The groups were also analyzed using a propensity-matching model, including transesophageal echocardiographic usage (GA [n=401] versus LA [n=401]). This model indicated that there were no significant differences between the 2 groups in the rates of 30-day survival (GA [91.4%] versus LA [89.3%]; P=0.27] and postprocedural aortic regurgitation≥mild (GA [12.7%] versus LA [16.2%]; P=0.19). Conclusions—The less invasive transfemoral-TAVI under LA is preferred in clinical settings and seems to be acceptable; however, the higher incidence of postprocedural aortic regurgitation is emphasized. Therapeutic efforts should be made to reduce such complications during transfemoral-TAVI under LA.
A Cubature Particle Filter Algorithm to Estimate the State of the Charge of Lithium-Ion Batteries Based on a Second-Order Equivalent Circuit Model

The state of charge (SOC) is the residual capacity of a battery. The SOC value indicates the mileage endurance, and an accurate SOC value is required to ensure the safe use of the battery to prevent over- and over-discharging. However, unlike size and weight, battery power is not easily determined. As a consequence, we can only estimate the SOC value based on the external characteristics of the battery. In this paper, a cubature particle filter (CPF) based on the cubature Kalman filter (CKF) and the particle filter (PF) is presented for accurate and reliable SOC estimation. The CPF algorithm combines the CKF and PF algorithms to generate a suggested density function for the PF algorithm based on the CKF. The second-order resistor-capacitor (RC) equivalent circuit model was used to approximate the dynamic performance of the battery, and the model parameters were identified by fitting. A dynamic stress test (DST) was used to separately estimate the accuracy and robustness of the CKF and the CPF algorithms. The experimental results show that the CPF algorithm exhibited better accuracy and robustness than the CKF algorithm.
Thyroid autoimmunity and function among Ugandan children and adolescents with type-1 diabetes mellitus

Introduction Up to 30% of type-1 diabetes mellitus (T1DM) patients have co-existent thyroid autoimmunity with up to 50% of them having associated thyroid dysfunction. Routine screening for thyroid autoimmunity and dysfunction is recommended in all T1DM patients. However, this was not currently practiced in Ugandan paediatric diabetes clinics. There was also paucity of data regarding thyroid autoimmunity and dysfunction in African children and adolescents with diabetes mellitus. The objective of this study was to quantify the magnitude of thyroid autoimmunity and dysfunction in Ugandan children with TIDM. Methods This was a cross sectional descriptive study to determine the prevalence of thyroid autoantibodies and describe thyroid function among children and adolescents aged 1-19 years with diabetes mellitus attending the paediatric diabetes clinic at Mulago National Referral Hospital, Kampala, Uganda. Following enrollment, we obtained details of clinical history and performed physical examination. Blood (plasma) was assayed to determine levels of antibodies to thyroid peroxidase (antiTPO), free thyroxine (FT4) and thyrotropin (TSH). Results The prevalence of thyroid autoimmunity was 7.3% (5/69). All antiTPO positive subjects were post pubertal, aged between 13-17 years with females comprising 3/5 of the antiTPO positive subjects. All study subjects were clinically euthyroid; however, 7.3% (5/69) of the study subjects had subclinical hypothyroidism. Conclusion These data strengthen the argument for routine screening of all diabetic children and adolescents for thyroid autoimmunity (particularly anti-TPO) as recommended by international guidelines. We also recommend evaluation of thyroid function in diabetic children and adolescents to minimize the risk of undiagnosed thyroid dysfunction.
Through-Life Assessment of Ductile Tearing under Low-Constraint

The paper outlines an innovative test procedure aimed at a comprehensive assessment of plane stress tearing in sheet metals and some results of its validation. This study gives an additional ground for updating the procedure by taking into account several experimental findings on the formation and extension of two slanted cracks emanating from a single open hole in plate-type specimens. The focus is on contrasting the ductile fracture behaviour under uncontained yielding in specimens with a small and a relatively large width-to-thickness ratio
An Evaluation of the Role the Internet Site Petfinder Plays in Cat Adoptions

To better understand factors contributing to cat adoptions, this study was used to explore a possible association between an adoptable cat's popularity on Petfinder and the cat's length of availability for adoption at a managed-intake nonhuman animal shelter. This study was also used to examine factors associated with a cat's popularity on Petfinder and the percentage of adopters who visited Petfinder before making adoption decisions. One third of adopters surveyed visited Petfinder before adopting, and half of those had viewed their adopted cats' Petfinder profiles. The number of clicks per day that cats received on the site was negatively correlated with their length of availability. Age at adoption was positively correlated with length of availability and negatively correlated with number of clicks per day. Coat color was a strong predictor of number of clicks per day and length of availability. The only variable within the photographer's control significantly associated with number of clicks per day was whether the photos included toys. Although cats' physical characteristics are strong predictors of their popularity, strategic use of toys in cats' photographs may promote adoptions of cats who are typically overlooked.
Injection Dependent Emitter Saturation Current Density Measurement under Metallized Areas Using Photoconductance Decay

We propose a novel method for the extraction of recombination characteristics of metal contacts on semiconductor substrates. We demonstrate this method for saturation current density measurements of contacts on boron doped emitters. It is easily generalized for the characterization of metallized high-low junctions, or of metal layers in direct contact with the bulk semiconductor. Our method is based on effective lifetime measurements as a function of metal contact area fraction. Under high injection conditions, saturation current densities of metallized junctions are extracted from the slope of the saturation current density as a function of metal coverage. At arbitrary injection levels, the difference between the saturation current density at metallized junctions and the saturation current density at passivated junctions is extracted from the slope of inverse effective lifetime versus metal contact fraction. If bulk recombination is negligible compared to emitter recombination, saturation current densities at the Simetal and at the passivated silicon surface can be independently determined for arbitrary injection levels. Our method is applied to saturation current density extraction for Al contacts on diffused boron emitters. Also, saturation currents at the emitter-air interface are extracted and compared to saturation current densities at the emitter-metal interface.
Effect of Prematurity on Cerebellar Growth

The aim of this study was to evaluate cerebellar growth of preterm infants. Vermis height and transverse cerebellar diameter were measured by cranial ultrasonography in 38 preterm infants (27-32 weeks) at birth and term equivalent age. Measurements were compared with 40 term appropriate-for-gestational-age infants. Preterms at term equivalent age had larger vermis height than term infants (2.39 ± 0.25 cm vs 2.25 ± 0.18 cm, P = .005), whereas no significant difference was found in the transverse cerebellar diameter (5.32 ± 0.38 cm vs 5.44 ± 0.23 cm, P = .13). Vermis height and transverse cerebellar diameter of appropriate-for-gestational-age preterm infants (n = 29) were found larger than small-for-gestational-age ones (n = 9). Vermis height and transverse cerebellar diameter at term equivalent age of appropriate-for-gestational-age preterm infants born before and after 29 weeks of age showed no significant difference. Cerebellar growth is preserved in extreme preterms. However, being small for gestational age may have deleterious effects on cerebellar development.
Economic value of pharmacist-led medication reconciliation for reducing medication errors after hospital discharge.

OBJECTIVES Medication discrepancies at the time of hospital discharge are common and can harm patients. Medication reconciliation by pharmacists has been shown to prevent such discrepancies and the adverse drug events (ADEs) that can result from them. Our objective was to estimate the economic value of nontargeted and targeted medication reconciliation conducted by pharmacists and pharmacy technicians at hospital discharge versus usual care. STUDY DESIGN Discrete-event simulation model. METHODS We developed a discrete-event simulation model to prospectively model the incidence of drug-related events from a hospital payer's perspective. The model assumptions were based on data published in the peer-reviewed literature. Incidences of medication discrepancies, preventable ADEs, emergency department visits, rehospitalizations, costs, and net benefit were estimated. RESULTS The expected total cost of preventable ADEs was estimated to be $472 (95% credible interval [CI], $247-$778) per patient with usual care. Under the base-case assumption that medication reconciliation could reduce medication discrepancies by 52%, the cost of preventable ADEs could be reduced to $266 (95% CI, $150-$423), resulting in a net benefit of $206 (95% CI, $73-$373) per patient, after accounting for intervention costs. A medication reconciliation intervention that reduces medication discrepancies by at least 10% could cover the initial cost of intervention. Targeting medication reconciliation to high-risk individuals would achieve a higher net benefit than a nontargeted intervention only if the sensitivity and specificity of a screening tool were at least 90% and 70%, respectively. CONCLUSIONS Our study suggests that implementing a pharmacist-led medication reconciliation intervention at hospital discharge could be cost saving compared with usual care.
Author ' s personal copy Thyroid function testing in elephant seals in health and disease

Northern Elephant Seal Skin Disease (NESSD) is a severe, ulcerative, skin condition of unknown cause affecting primarily yearling northern elephant seals (Mirounga angustirostris); it has been associated with decreased levels of circulating thyroxine (T4) and triiodothyronine (T3). Abnormalities of the thyroid gland that result in decreased hormone levels (hypothyroidism) can result in hair loss, scaling and secondary skin infections. However, concurrent illness (including skin ailments) can suppress basal levels of thyroid hormones and mimic hypothyroidism; when this occurs in animals with normal thyroid glands it is called ‘‘sick euthyroid syndrome’’. The two conditions (true hypothyroidism vs. ‘‘sick euthyroid’’) can be distinguished in dogs by testing the response of the thyroid gland to exogenous thyrotropin (Thyroid Stimulating Hormone, TSH). To determine whether hypothyroidism is involved in the etiology of NESSD, we tested thyroid function of stranded yearling elephant seals in the following categories: healthy seals (rehabilitated and ready for release; N = 9), seals suffering from NESSD (N = 16) and seals with other illnesses (e.g., lungworm pneumonia; N = 10). Levels of T4 increased significantly for all three categories of elephant seals following TSH stimulation, suggesting that seals with NESSD are ‘‘sick euthyroid’’ and that the disease is not associated with abnormal thyroid gland function. 2007 Elsevier Inc. All rights reserved.
Laws of Graph Evolution: Densification and Shrinking Diameters

How do real graphs evolve over time? What are “normal” growth patterns in social, technological, and information networks? Many studies have discovered patterns in static graphs, identifying properties in a single snapshot of a large network, or in a very small number of snapshots; these include heavy tails for inand out-degree distributions, communities, small-world phenomena, and others. However, given the lack of information about network evolution over long periods, it has been hard to convert these findings into statements about trends over time. Here we study a wide range of real graphs, and we observe some surprising phenomena. First, most of these graphs densify over time, with the number of edges growing super-linearly in the number of nodes. Second, the average distance between nodes often shrinks over time, in contrast to the conventional wisdom that such distance parameters should increase slowly as a function of the number of nodes (like O(log n) or O(log(log n)). Existing graph generation models do not exhibit these types of behavior, even at a qualitative level. We provide a new graph generator, based on a “forest fire” spreading process, that has a simple, intuitive justification, requires very few parameters (like the “flammability” of nodes), and produces graphs exhibiting the full range of properties observed both in prior work and in the present study. We also notice that “forest fire” exhibits a sharp transition between sparse graphs and graphs that are densifying. Graphs with decreasing distance between the nodes are generated around this transition point. Last, we analyze the connection between the temporal evolution of degree distribution and densification of a graph. We find that the two are fundamentally related. We also observe that real datasets exhibit this type of relation.
Larger sperm outcompete smaller sperm in the nematode Caenorhabditis elegans

Sperm competition is generally thought to drive the evolution of sperm miniaturization. Males gain advantage by transferring more sperm, which they produce by dividing limited resources into ever smaller cells. Here, we describe the opposite effect of size on the competitiveness of amoeboid sperm in the hermaphroditic nematode Caenorhabditis elegans. Larger sperm crawled faster and displaced smaller sperm, taking precedence at fertilization. Larger sperm took longer to produce, however, and so were more costly than smaller sperm. Our results provide evidence of a mechanism to support recent theoretical and comparative studies that suggest sperm competition can favour not small, but large sperm.
Bounded-error quantum state identification and exponential separations in communication complexity

We consider the problem of bounded-error quantum state identification: given either state α0 or state α1, we are required to output '0', '1' or 'DONO' ("don't know"), such that conditioned on outputting '0' or '1', our guess is correct with high probability. The goal is to maximize the probability of not outputting 'DONO'. We prove a direct product theorem: if we're given two such problems, with optimal probabilities a and b, respectively, and the states in the first problem are pure, then the optimal probability for the joint bounded-error state identification problem is O(ab). Our proof is based on semidefinite programming duality and may be of wider interest.Using this result, we present two exponential separations in the simultaneous message passing model of communication complexity. First, we describe a relation that can be computed with O(log n) classical bits of communication in the presence of shared randomness, but needs Ω(n1/3) communication if the parties don't share randomness, even if communication is quantum. This shows the optimality of Yao's recent exponential simulation of shared-randomness protocols by quantum protocols without shared randomness. Second, we describe a relation that can be computed with O(log n) classical bits of communication in the presence of shared entanglement, but needs Ω((n/log n)1/3) communication if the parties share randomness but no entanglement, even if communication is quantum. This is the first example in communication complexity where entanglement buys you much more than quantum communication does.
SURFACTANT PROPERTIES OF THE SAPONINS OF Agave Durangensis, APPLICATION ON ARSENIC REMOVAL

The saponin composition of Agave durangensis foliar tissue was assessed by HPLC/DAD to determine the diversity and abundance of these secondary metabolites in that taxon, and also to analyze, the surfacting properties of those terpenic derivatives for removing arsenic in water. Four different steroidal saponins were detected at concentrations ranging from 0.380 to 3.472 mg/g dry tissue, in the leaves of this species of Agave, which are removed and left in the field as waste, when the plants are gathered to elaborate mescal. The total concentration of saponins estimated ((6.165 mg/g dry tissue) suggests that A. durangensis is an important source of steroidal saponins, having relevant properties for removing arsenic from water (above 90%). This study is a contribution to the knowledge of that species of plant and reveals a potential additional use to the integral management of this resource.
Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel

Objective The clinical use of paclitaxel is limited by variable responses and the potential for significant toxicity. To date, studies of associations between variants in candidate genes and paclitaxel effects have yielded conflicting results. We aimed to evaluate the relationships between global gene expression and paclitaxel sensitivity. Methods We utilized well-genotyped lymphoblastoid cell lines derived from the International HapMap Project to evaluate the relationships between cellular susceptibility to paclitaxel and global gene expression. Cells were exposed to varying concentrations of paclitaxel to evaluate paclitaxel-induced cytotoxicity and apoptosis. Among the top genes, we identified solute carrier (SLC) genes associated with paclitaxel sensitivity and narrowed down the list to those that had single nucleotide polymorphisms associated with both the expression level of the SLC gene and also with paclitaxel sensitivity. We performed an independent validation in an independent set of cell lines and also conducted functional studies using RNA interference. Results Of all genes associated with paclitaxel-induced cytotoxicity at P less than 0.05 (1713 genes), there was a significant enrichment in SLC genes (31 genes). A subset of SLC genes, namely SLC31A2, SLC43A1, SLC35A5, and SLC41A2, was associated with paclitaxel sensitivity and had regulating single nucleotide polymorphisms that were also associated with paclitaxel-induced cytotoxicity. Multivariate modeling demonstrated that those four SLC genes together explained 20% of the observed variability in paclitaxel susceptibility. Using RNA interference, we demonstrated increased paclitaxel susceptibility with knockdown of three SLC genes, SLC31A2, SLC35A5, and SLC41A2. Conclusion Our findings are novel and lend further support to the role of transporters, specifically solute carriers, in mediating cellular susceptibility to paclitaxel.
Interactions between Speed and Contrast Tuning in the Middle Temporal Area: Implications for the Neural Code for Speed

A car driving through the fog appears to move more slowly than one driving on a clear and sunny day. In the laboratory, this observation has been confirmed as a pronounced reduction of perceived speed caused by a reduction in contrast. We measured the influence of contrast on cells in the middle temporal area (MT) of the macaque, which has been hypothesized to underlie the perception of speed. The influence of contrast on the responsiveness and speed tuning of these cells was pervasive and highly regular. As expected, most cells responded less at low contrast. More importantly, the preferred speed of most cells shifted to lower speeds at lower contrasts. Moreover, approximately one-third of cells surprisingly responded more strongly to slow low-contrast stimuli than to slow high-contrast stimuli. Current models of speed perception suggest that each MT cell votes for its preferred speed, with a vote determined by its firing rate. We tested a number of these labeled-line models by entering the neural responses we recorded from MT and comparing the predictions of the models with the perceptual reports of human subjects and monkeys. Contrary to the perceptual reports, the labeled-line models predicted that perceived speed should increase when contrast is decreased. We therefore conclude that perceived speed is not based on a labeled-line interpretation of MT cells.