Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of T1-Weighted MRI to Detect Intratumoral Hemorrhage Within Papillary Renal Cell Carcinoma as a Feature Differentiating From Angiomyolipoma Without Visible Fat.

OBJECTIVE The objective of the present study is to determine whether hemorrhage within papillary renal cell carcinoma (RCC) can be detected using T1-weighted MRI and to ascertain whether it can be used to differentiate papillary RCC from angiomyolipoma (AML) without visible fat. MATERIALS AND METHODS A retrospective case-control study compared 11 AMLs without visible fat with 58 papillary RCCs smaller than 5 cm that were evaluated using MRI between 2003 and 2015. Two blinded radiologists subjectively evaluated MR images to identify the presence of intratumoral hemorrhage on the basis of a decrease in signal intensity (SI) on in-phase, compared with opposed-phase, chemical-shift MRI and also on the basis of the SI of the lesion compared with that of the renal cortex on fat-suppressed T1-weighted MRI. A third radiologist established consensus and measured the ratio of the SI of the lesion to that of the renal cortex (hereafter referred to as the "SI ratio") on T2-weighted MRI; the SI loss index, as calculated using the equation [(SItumorIP - SItumorOP) / SItumorOP] × 100, where IP denotes the in-phase image and OP denotes the opposed-phase image; and the SI ratio on fat-suppressed T1-weighted MRI. Analyses were performed using tests of association and ROCs. RESULTS When AMLs without visible fat were compared with papillary RCCs, no statistically significant difference in the T2-weighted SI ratio was noted (p = 0.08). Papillary RCCs had a lower mean (± SD) SI loss index (-3.7% ± 17.3%; range, -51.3% to 31.3%) than did AMLs without visible fat (37.8% ± 76.1%; range, -15.6% to 184.4%) (p < 0.001). A mean SI loss index of less than -16% resulted in an AUC of 0.71 (95% CI, 0.52-0.91), with a sensitivity and specificity of 22.8% and 100%, respectively, for the diagnosis of papillary RCC. After consensus review, none of the AMLs without visible fat and 16 of the 58 papillary RCCs (27.6%) were found to have a decrease in SI on subjective analysis (p = 0.06, κ = 0.60). Between groups, no differences were noted in the SI ratio on fat-suppressed T1-weighted MRI (p = 0.58) or in the SI observed on subjective analysis of fat-suppressed T1-weighted MRI (p = 0.20, κ = 0.48). CONCLUSION The presence of intratumoral hemorrhage within papillary RCC is a specific feature that differentiates papillary RCCs from AMLs without visible fat. Subjective analysis may be more clinically appropriate than chemical-shift MRI because of limitations in the quantitative measurement of T2* signal with the use of chemical-shift MRI.
Voice Identity Recognition: Functional Division of the Right STS and Its Behavioral Relevance

Abstract The human voice is the primary carrier of speech but also a fingerprint for person identity. Previous neuroimaging studies have revealed that speech and identity recognition is accomplished by partially different neural pathways, despite the perceptual unity of the vocal sound. Importantly, the right STS has been implicated in voice processing, with different contributions of its posterior and anterior parts. However, the time point at which vocal and speech processing diverge is currently unknown. Also, the exact role of the right STS during voice processing is so far unclear because its behavioral relevance has not yet been established. Here, we used the high temporal resolution of magnetoencephalography and a speech task control to pinpoint transient behavioral correlates: we found, at 200 msec after stimulus onset, that activity in right anterior STS predicted behavioral voice recognition performance. At the same time point, the posterior right STS showed increased activity during voice identity recognition in contrast to speech recognition whereas the left mid STS showed the reverse pattern. In contrast to the highly speech-sensitive left STS, the current results highlight the right STS as a key area for voice identity recognition and show that its anatomical-functional division emerges around 200 msec after stimulus onset. We suggest that this time point marks the speech-independent processing of vocal sounds in the posterior STS and their successful mapping to vocal identities in the anterior STS.
Juvenile thyroid malignancy

Thyroid malignancy is an uncommon tumor of the pediatric population. Patients can present with asymptomatic thyroid nodule and it requires thorough work up to rule out the malignancy. Radiological and pathological procedures are a standard part of the management. A 10-year-old girl had asymptomatic thyroid nodule; the cytological examination and the frozen section and final histology of the nodule was different each time. The girl had to undergo total thyroidectomy on the basis of histology of the nodule which was well differentiated papillary carcinoma of thyroid and is under regular follow-up for last two years on thyroid supplementation.
The relationship between senior management team culture and clinical governance: Empirical investigation and managerial implications

Background: Health care organizations are pressured to improve the cost-effectiveness of service delivery. Clinical governance is an important trigger to improve care quality and safety and rank high in the reform agenda of health systems. The senior management team culture plays a major role in establishing clinical governance practices, because it strongly influences the values, attitudes, and behaviors of the members of an organization. Purposes: The aim of this study was to investigate the relationship between senior management team culture and clinical governance in the public health care organizations of three Italian regions. Methodology: The assessment of senior management culture was conducted using the Competing Values Framework and a corresponding instrument adapted for the Italian context. Clinical governance was assessed using an ad hoc instrument focused on the senior management team’s perception and attitude toward clinical governance. Findings: The survey achieved a 54% response rate. The results of four different models demonstrate that organizations characterized by different dominant cultures are associated with significant differences in attitudes toward clinical governance. In particular, on average, dominant cultures with a prevailing external focus are associated with a more positive attitude toward clinical governance. Practice Implications: The selection and appointments of top managers should consider the style of leadership that is most apt to facilitate the growth of rational and developmental cultures. Furthermore, the training of top managers and leading doctors should reinforce leadership aptitude and approaches that are consistent with the desired organizational cultures.
Inoculum Effect on the Efficacies of Amoxicillin-Clavulanate, Piperacillin-Tazobactam, and Imipenem against Extended-Spectrum β-Lactamase (ESBL)-Producing and Non-ESBL-Producing Escherichia coli in an Experimental Murine Sepsis Model

ABSTRACT Escherichia coli is commonly involved in infections with a heavy bacterial burden. Piperacillin-tazobactam and carbapenems are among the recommended empirical treatments for health care-associated complicated intra-abdominal infections. In contrast to amoxicillin-clavulanate, both have reduced in vitro activity in the presence of high concentrations of extended-spectrum β-lactamase (ESBL)-producing and non-ESBL-producing E. coli bacteria. Our goal was to compare the efficacy of these antimicrobials against different concentrations of two clinical E. coli strains, one an ESBL-producer and the other a non-ESBL-producer, in a murine sepsis model. An experimental sepsis model {∼5.5 log10 CFU/g [low inoculum concentration (LI)] or ∼7.5 log10 CFU/g [high inoculum concentration (HI)]} using E. coli strains ATCC 25922 (non-ESBL producer) and Ec1062 (CTX-M-14 producer), which are susceptible to the three antimicrobials, was used. Amoxicillin-clavulanate (50/12.5 mg/kg given intramuscularly [i.m.]), piperacillin-tazobactam (25/3.125 mg/kg given intraperitoneally [i.p.]), and imipenem (30 mg/kg i.m.) were used. Piperacillin-tazobactam and imipenem reduced spleen ATCC 25922 strain concentrations (−2.53 and −2.14 log10 CFU/g [P < 0.05, respectively]) in the HI versus LI groups, while amoxicillin-clavulanate maintained its efficacy (−1.01 log10 CFU/g [no statistically significant difference]). Regarding the Ec1062 strain, the antimicrobials showed lower efficacy in the HI than in the LI groups: −0.73, −1.89, and −1.62 log10 CFU/g (P < 0.05, for piperacillin-tazobactam, imipenem, and amoxicillin-clavulanate, respectively, although imipenem and amoxicillin-clavulanate were more efficacious than piperacillin-tazobactam). An adapted imipenem treatment (based on the time for which the serum drug concentration remained above the MIC obtained with a HI of the ATCC 25922 strain) improved its efficacy to −1.67 log10 CFU/g (P < 0.05). These results suggest that amoxicillin-clavulanate could be an alternative to imipenem treatment of infections caused by ESBL- and non-ESBL-producing E. coli strains in patients with therapeutic failure with piperacillin-tazobactam.
Consistent event-triggered methods for linear quadratic control

In this paper, we define two desired consistency properties for event-triggered control: (i) it should result in a better trade-off between average transmission rate and close-dloop performance than traditional periodic control; (ii) it should require no sensor updates (i.e., operate in open loop) in the absence of disturbances. We propose an event-triggered controller for linear systems with full state feedback that guarantees these two properties when performance is measured by an average quadratic cost. Simulation results highlight the efficiency of the proposed solution.
G2 histone methylation is required for the proper segregation of chromosomes

Trimethylation of lysine 9 on histone H3 (H3K9me3) is known both to be necessary for proper chromosome segregation and to increase in late G2. We investigated the role of late G2 methylation, specifically in mitotic progression, by inhibiting methylation for 2 hours prior to mitosis using the general methylation inhibitor adenosine dialdehyde (AdOx). AdOx inhibits all methylation events within the cell but, by shortening the treatment length to 2 hours and studying mitotic cells, the only methylation events that are affected are those that occur in late G2. We discovered that methylation events in this time period are crucial for proper mitosis. Mis-segregation of chromosomes is observed with AdOx treatment. Through studies of histone modifications, we have found that inhibiting late G2 methylation affects trimethylation of H3K9 and H4K20. The mitotic checkpoint is active and many kinetochore proteins localize properly, however, pericentric chromatin in these cells is found to be less compact (dense). The reduced integrity of pericentric heterochromatin might be responsible for a noted loss of tension at the centromere in AdOx-treated cells and activation of the spindle assembly checkpoint. We postulate that late G2 methylation is necessary for proper pericentric heterochromatin formation. The results suggest that a reduction in heterochromatin integrity might interfere both with microtubule attachment to chromosomes and with the proper sensing of tension from correct microtubule-kinetochore connections, either of which will result in activation of the mitotic checkpoint.
Properties of the warm magnetized ISM, as inferred from WSRT polarimetric imaging

We describe a first attempt to derive properties of the regular and turbulent Galactic magnetic field from multi-frequency polarimetric observations of the diffuse Galactic synchrotron background. A single-cell-size model of the thin Galactic disk is constructed which includes random and regular magnetic fields and thermal and relativistic electrons. The disk is irradiated from behind with a uniform partially polarized background. Radiation from the background and from the thin disk is Faraday rotated and depolarized while propagating through the medium. The model parameters are estimated from a comparison with 350 MHz observations in two regions at intermediate latitudes done with the Westerbork Synthesis Radio Telescope. We obtain good agreement between the estimates for the random and regular magnetic field strengths and typical scales of structure in the two regions. The regular magnetic field strength found is a few muG, and the ratio of random to regular magnetic field strength B-ran/B-reg is 0.7 +/- 0.5, for a typical scale of the random component of 15 +/- 10 pc. Furthermore, the regular magnetic field is directed almost perpendicular to the line of sight. This modeling is a potentially powerful method to estimate the structure of the Galactic magnetic field, especially when more polarimetric observations of the diffuse synchrotron background at intermediate latitudes become available.
A double-reprocessing high-level disinfection protocol does not eliminate positive cultures from the elevators of duodenoscopes

Abstract Background and study aim Duodenoscopes have been the source of serious infection, despite correct performance of high-level disinfection (HLD). This study aimed to observe the impact of performing HLD twice on the rate of positive cultures from duodenoscope elevators. Methods We performed double HLD (DHLD; i. e. complete manual cleaning followed by automated reprocessing, with the entire process repeated) and then randomly cultured the elevators of our duodenoscopes on about 30 % of occasions. Results DHLD was associated with positive elevator cultures for any microorganism in 9.4 % of cases, with a 0.8 % rate of known pathogens (627 cultures) between May 2015 and February 2016. After February 2016, and in association with changing the precleaning fluid, as well as use of a new FDA-recommended cleaning brush, the rate of positive cultures for any microorganism after DHLD was 4.8 % and 0.2 % for known pathogens (420 cultures). In a third phase, characterized by a change in personnel performing DHLD and retirement of a duodenoscope with a high rate of positive cultures, the rate of positive cultures for any microorganism was 4.9 % (783 cultures) and the rate of positive culture for known pathogens was 0.3 %. To our knowledge, no duodenoscope transmission of infection occurred during the study interval. Conclusions DHLD resulted in a low rate of positive cultures for known pathogens and for organisms of low pathogenic potential, but did not eliminate these, from duodenoscope elevators. Additional improvements in HLD protocols and/or duodenoscope design are needed.
On self duality of pathwidth in polyhedral graph embeddings

Let G be a 3‐connected planar graph and G* be its dual. We show that the pathwidth of G* is at most 6 times the pathwidth of G. We prove this result by relating the pathwidth of a graph with the cut‐width of its medial graph and we extend it to bounded genus embeddings. We also show that there exist 3‐connected planar graphs such that the pathwidth of such a graph is at least 1.5 times the pathwidth of its dual. © 2007 Wiley Periodicals, Inc. J Graph Theory 55: 42–54, 2007
Photoresins based on acrylated epoxidized soybean oil and benzenedithiols for optical 3D printing

Purpose The purpose of this paper is the design and investigation of novel acrylated epoxidized soybean oil-based photocurable systems as candidate materials for optical 3D printing. Design/methodology/approach Aromatic dithiols, benzene-1,3-dithiol or benzene-1,4-dithiol, were used as cross-linking agents of acrylated epoxidized soybean oil in these systems. Kinetics of photocross-linking was investigated by real-time photorheometry using two different photoinitiators, 2, 2-dimethoxy-2-phenylacetophenone or 2-hydroxy-2-methylpropiophenone, in different quantities. The effect of the initial composition on the rate of photocross-linking, mechanical, thermal properties and swelling of obtained polymers was investigated. Findings The rate of photocross-linking was higher, more cross-links and shorter polymer chains between cross-linking points of the network were formed when benzene-1,4-dithiol and 2, 2-dimethoxy-2-phenylacetophenone were used in compositions. The higher yield of insoluble fraction, glass transition temperatures and values of compressive modulus were obtained when benzene-1,3-dithiol and 2, 2-dimethoxy-2-phenylacetophenone were used in compositions. Originality/value This is the first study of acrylated epoxidized soybean oil-based thiol-ene system by real-time photorheometry. The designed novel photocurable systems based on acrylated epoxidized soybean oil and benzenedithiols are promising renewable photoresins for rapid optical 3D printing on demand.
Hydrogen and its radiation effects in quartz crystals

This paper presents near infrared absorption measurements (in the region of 3100-3700 cm/sup -1/) on quartz crystals to characterize the aluminum- and alkali-related hydroxyl defects in a variety of natural and cultured quartz crystals. Quartz samples were irradiated with an electron beam of 1.75 MeV and a dose of 2 Mrad at 77 K before and after irradiation at 300 K. The alkalis in quartz move under irradiation field only if the sample temperature is about or above 200 K, but the protons move at all temperatures down to 10 K. Therefore, irradiation at 300 K allows movement of both, protons and alkali ions, thus breaking away the aluminum-alkali centers into a mixture of Al-OH/sup -/ and Al-hole centers. The natural quartz crystals have been measured with nearly similar Al and widely varying H-levels. For a similar radiation dose at 300 K, contrary to expectation, a lesser number of Al-OH/sup -/ centers were produced in crystal with higher H-level than the sample with low-H quartz. At the present stage of work, we expect that this may be due to jamming in the kinetics of large number of protons in high-H crystals for steric reasons, which prevents them from reaching Al-sites after irradiation.
Human regulatory T cells are selectively activated by low‐dose application of the CD28 superagonist TGN1412/TAB08

CD28 superagonists (CD28SAs) are potent T‐cell‐activating monoclonal antibodies (mAbs). In contrast to their benign behavior and marked therapeutic efficacy as activators of regulatory T (Treg) cells in preclinical rodent models, a phase I trial of the human CD28SA TGN1412 (now called TAB08) in 2006 resulted in a life‐threatening cytokine release syndrome (CRS). We studied TAB08‐mediated Treg‐cell activation in a recently developed in vitro system of human PBMCs, which also reproduces the CRS experienced by the healthy volunteers. We show that just as in rodents, CD28SAs are potent activators and expanders of Treg cells from healthy donors and rheumatoid arthritis patients, even under effective blockade of pro‐inflammatory cytokine release by a corticosteroid. Moreover, CD28SA titration identifies a dose range where pro‐inflammatory cytokine secretion from conventional T cells is absent while appreciable Treg‐cell activation is maintained. Finally, we report that low‐dose application of TAB08 to healthy volunteers results in dose‐dependent systemic release of the Treg‐cell signature cytokine IL‐10 in the absence of the pro‐inflammatory factors associated with the CRS of the 2006 TGN1412 study. These results demonstrate the potential of appropriately dosed CD28SA and corticosteroid comedication to mobilize human Treg cells for the treatment of autoimmune and inflammatory conditions.
Long‐Term Outcome of Left Atrial Voltage‐Guided Substrate Ablation During Atrial Fibrillation: A Novel Adjunctive Ablation Strategy

Left atrium (LA) low voltage area (LVA) on 3‐D electroanatomic bipolar voltage mapping (EAVM), as a surrogate for scar, is associated with poor AF ablation outcome. We evaluated the long‐term outcome of an LVA‐guided atrial fibrillation (AF) substrate modification strategy as an adjunct to pulmonary vein isolation (PVI).
Effect of Grain Size on the Yield Stress of Cold Worked Iron

Effect of ferrite grain size on dislocation strengthening was investigated in low carbon steels (0.006%C-0.15%C) with various grain sizes from 1 to 100 μ m. In specimens with slight deformation, dislocation density increases in proportion to the inverse of ferrite grain size. In the dislocation density range below 2 × 10 14 /m 2 , dislocation density increases linearly against deformation strain but it tends to level off due to the dynamic recovery of dislocations when dislocation density has exceeded it. On the other hand, tensile tests revealed that yield stress follows the Hall-Petch relation for as-annealed specimens but follows the Bailey-Hirsch relation for cold rolled specimens. This means that flow stress depends on only the dislocation density regardless of grain size. As a result, it was concluded that the introduction of dislocations has been promoted with decreasing ferrite grain size and this results in the increase of flow stress in the uniform deformation region.
Diffeomorphism invariant Quantum Field Theories of Connections in terms of webs

In the canonical quantization of gravity in terms of the Ashtekar variables one uses paths in the 3-space to construct the quantum states. Usually, one restricts oneself to families of paths admitting only a finite number of isolated intersections. This assumption implies a limitation on the diffeomorphisms invariance of the introduced structures. In this work, using the previous results of Baez and Sawin, we extend the existing results to a theory admitting all the possible piecewise-smooth finite paths and loops. In particular, we (a) characterize the spectrum of the Ashtekar-Isham configuration space, (b) introduce spin-web states, a generalization of the spin-network states, (c) extend the diffeomorphism averaging to the spin-web states and derive a large class of diffeomorphism-invariant states and finally (d) extend the 3-geometry operators and the Hamiltonian operator.
Optogenetic interrogation of integrin αVβ3 function in endothelial cells

ABSTRACT The integrin αVβ3 is reported to promote angiogenesis in some model systems but not in others. Here, we used optogenetics to study the effects of αVβ3 interaction with the intracellular adapter kindlin-2 (Fermt2) on endothelial cell functions potentially relevant to angiogenesis. Because interaction of kindlin-2 with αVβ3 requires the C-terminal three residues of the β3 cytoplasmic tail (Arg-Gly-Thr; RGT), optogenetic probes LOVpep and ePDZ1 were fused to β3ΔRGT–GFP and mCherry–kindlin-2, respectively, and expressed in β3 integrin-null microvascular endothelial cells. Exposure of the cells to 450 nm (blue) light caused rapid and specific interaction of kindlin-2 with αVβ3 as assessed by immunofluorescence and total internal reflection fluorescence (TIRF) microscopy, and it led to increased endothelial cell migration, podosome formation and angiogenic sprouting. Analyses of kindlin-2 mutants indicated that interaction of kindlin-2 with other kindlin-2 binding partners, including c-Src, actin, integrin-linked kinase and phosphoinositides, were also likely necessary for these endothelial cell responses. Thus, kindlin-2 promotes αVβ3-dependent angiogenic functions of endothelial cells through its simultaneous interactions with β3 integrin and several other binding partners. Optogenetic approaches should find further use in clarifying spatiotemporal aspects of vascular cell biology. Highlighted Article: Optogenetics show that the interaction of kindlin-2 with β3 integrin and other binding partners supports endothelial cell functions relevant to angiogenesis, including sprouting and podosome formation.