Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of the Framingham general cardiovascular risk score in a multiethnic Asian population: a retrospective cohort study

Objective This study aims to examine the validity of the Framingham general cardiovascular disease (CVD) risk chart in a primary care setting. Design This is a 10-year retrospective cohort study. Setting A primary care clinic in a teaching hospital in Malaysia. Participants 967 patients’ records were randomly selected from patients who were attending follow-up in the clinic. Main outcome measures Baseline demographic data, history of diabetes and smoking, blood pressure (BP), and serum lipids were captured from patient records in 1998. Each patient's Framingham CVD score was computed from these parameters. All atherosclerotic CVD events occurring between 1998 and 2007 were counted. Results In 1998, mean age was 57 years with 33.8% men, 6.1% smokers, 43.3% diabetics and 59.7% hypertensive. Median BP was 140/80 mm Hg and total cholesterol 6.0 mmol/L (1.3). The predicted median Framingham general CVD risk score for the study population was 21.5% (IQR 1.2–30.0) while the actual CVD events that occurred in the 10 years was 13.1% (127/967). The median CVD points for men was 30.0, giving them a CVD risk of more than 30%; for women it is 18.5, a CVD risk of 21.5%. Our study found that the Framingham general CVD risk score to have moderate discrimination with an area under the receiver operating characteristic curve (AUC) of 0.63. It also discriminates well for Malay (AUC 0.65, p=0.01), Chinese (AUC 0.60, p=0.03), and Indians (AUC 0.65, p=0.001). There was good calibration with Hosmer-Lemeshow test χ2=3.25, p=0.78. Conclusions Taking into account that this cohort of patients were already on treatment, the Framingham General CVD Risk Prediction Score predicts fairly accurately for men and overestimates somewhat for women. In the absence of local risk prediction charts, the Framingham general CVD risk prediction chart is a reasonable alternative for use in a multiethnic group in a primary care setting.
Arginine Metabolism by Macrophages Promotes Cardiac and Muscle Fibrosis in mdx Muscular Dystrophy

Background Duchenne muscular dystrophy (DMD) is the most common, lethal disease of childhood. One of 3500 new-born males suffers from this universally-lethal disease. Other than the use of corticosteroids, little is available to affect the relentless progress of the disease, leading many families to use dietary supplements in hopes of reducing the progression or severity of muscle wasting. Arginine is commonly used as a dietary supplement and its use has been reported to have beneficial effects following short-term administration to mdx mice, a genetic model of DMD. However, the long-term effects of arginine supplementation are unknown. This lack of knowledge about the long-term effects of increased arginine metabolism is important because elevated arginine metabolism can increase tissue fibrosis, and increased fibrosis of skeletal muscles and the heart is an important and potentially life-threatening feature of DMD. Methodology We use both genetic and nutritional manipulations to test whether changes in arginase metabolism promote fibrosis and increase pathology in mdx mice. Our findings show that fibrotic lesions in mdx muscle are enriched with arginase-2-expressing macrophages and that muscle macrophages stimulated with cytokines that activate the M2 phenotype show elevated arginase activity and expression. We generated a line of arginase-2-null mutant mdx mice and found that the mutation reduced fibrosis in muscles of 18-month-old mdx mice, and reduced kyphosis that is attributable to muscle fibrosis. We also observed that dietary supplementation with arginine for 17-months increased mdx muscle fibrosis. In contrast, arginine-2 mutation did not reduce cardiac fibrosis or affect cardiac function assessed by echocardiography, although 17-months of dietary supplementation with arginine increased cardiac fibrosis. Long-term arginine treatments did not decrease matrix metalloproteinase-2 or -9 or increase the expression of utrophin, which have been reported as beneficial effects of short-term treatments. Conclusions/Significance Our findings demonstrate that arginine metabolism by arginase promotes fibrosis of muscle in muscular dystrophy and contributes to kyphosis. Our findings also show that long-term, dietary supplementation with arginine exacerbates fibrosis of dystrophic heart and muscles. Thus, commonly-practiced dietary supplementation with arginine by DMD patients has potential risk for increasing pathology when performed for long periods, despite reports of benefits acquired with short-term supplementation.
Effects of a moderate low-carbohydrate diet on preferential abdominal fat loss and cardiovascular risk factors in patients with type 2 diabetes

Background: Reports have shown that visceral adipose tissue (VAT) is more closely linked to cardiovascular risk factors (CRFs) than subcutaneous adipose tissue (SAT). We aimed to elucidate preferential abdominal fat loss and the correlations between abdominal fat reductions and changes in CRFs achieved with a moderate low-carbohydrate diet (LCD) in patients with type 2 diabetes (T2DM). Patients and methods: Fifty-two outpatients (28 men and 24 women, mean age ± SD: 60.0 ± 10.5 years) with hemoglobin A1c (HbAlc) levels ≥ 6.5% were on an LCD for 6 months. Over a 6-month period, we measured their abdominal fat distribution (using CT) and assessed CRFs, including body mass index (BMI), HbA1c, fasting blood glucose (FBG), serum insulin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride levels. Results: The patients showed good compliance with the LCD (1812 ± 375 kcal/day, % carbohydrate:fat:protein = 35:40:19 for men; 1706 ± 323 kcal/day, % carbohydrate:fat:protein = 41:36:21 for women). Significant decreases (P = 0.05) in BMI and HbA1c levels were observed, along with an increase in HDL-C (P = 0.021) in men and a decrease in LDL-C (P = 0.001) in women. VAT (−21.6 cm2, P < 0.001 in men; −19.6 cm2, P < 0.001 in women) and SAT (−13.5 cm2, P = 0.004 in men; −19.1 cm2, P = 0.003 in women) significantly decreased. The loss of VAT (%ΔVAT) was greater than that of SAT (%ΔSAT) in women (P = 0.022). A similar but not significant predominance of VAT loss was detected in men (P = 0.111). In women, the %ΔSAT significantly correlated with changes in FBG (ΔFBG) (r = 0.417) and HDL-C (ΔHDL) (r = −0.720), as was %ΔVAT with changes in triglyceride (ΔTG) (r = 0.591). Conclusion: Six months of a moderate LCD resulted in preferential VAT loss only in women, with significant correlations between %ΔSAT and both ΔHDL and ΔFBG, as well as between %ΔVAT and ΔTG. Our results suggest that an LCD has the potential to reduce abdominal fat in patients with T2DM and deterioration of serum lipid profiles.
Clinical Characteristics and Survival of Patients with Pulmonary Hypertension:A 40-Month Mean Follow-Up

Introduction: The aim of our study was to describe the characteristics and clinical outcomes of pulmonary hypertension (PH) patients who underwent their follow-up at a single centre. Methods: We included patients who fulfilled the criteria for the diagnosis of PH by right heart catheterisation. A detailed clinical history and complete physical examination were recorded for each patient. Demographic data, laboratory testing, hemodynamic values and treatment records were also collected. A 6-minute walk test was used to evaluate exercise capacity. Survival analysis was performed using the Kaplan-Meier method, and a log-rank test was used to compare survival curves among groups. A multivariate Cox’s proportional hazards model was used in order to identify independent predictors of mortality in the overall PH population. Results: A total of 93 patients (64 women and 29 men) were studied. The patients were distributed across the groups as follows: 50.5% in group 1, 20.4% in group 2, 9.7% in group 3, 14% in group 4 and 5.4% in group 5. The most common type of PH in our population was portopulmonary hypertension followed by PH associated with leftheart disease, and idiopathic and chronic thromboembolic disease. Nineteen deaths, constituting 20.5% of the sample population, were reported. The Kaplan-Meier estimates of the 1-, 2-, and 3-year survival rates were 91%, 89%, and 85%, respectively. There were no statistically significant differences in survival among the groups (p=0.18). A multivariate analysis revealed that the cardiac index (CI) was an independent predictor of death. Conclusions: The survival rates of PH patients are higher than previously reported. In our study, the largest number of deaths occurred in groups 1 and 2, and CI was found to be an independent predictor of mortality.
Role of cognitive control in language deficits in different types of aphasia

ABSTRACT Background: Although studies show that different facets of cognitive control are impaired in persons with aphasia (PWA), the question how they impact language abilities in different types of aphasia remains open. Aims: Following the hypothesis that diminished attention contributes to language impairments in aphasia, we predicted that both fluent and non-fluent PWA would perform worse than neurologically intact individuals on verbal and non-verbal cognitive control tasks. Also, testing the view that linguistic disturbances in fluent and non-fluent PWA dissociate, we predicted differential relationships in performance on cognitive control tasks and language impairment. Methods & Procedures: Fluent PWA (N = 17) and non-fluent PWA (N = 14) were compared to unimpaired speakers (N = 21) on the non-verbal Flanker task tapping domain-general cognitive control, and Stroop task measuring verbal cognitive control, as well as subtests from the Russian version of the Birmingham Cognitive Screen, namely the Auditory Control task tapping verbal cognitive control and the Rule Finding task measuring domain-general cognitive control. All PWA completed picture naming and language comprehension tasks. Outcomes & Results: All PWA were more impaired on the Stroop and Auditory Control tasks, with no impairment on the non-verbal Flanker task compared to the controls. Non-fluent PWA also performed significantly worse on the Rule Finding that requires forming and updating non-verbal relational representations. Differences between aphasia groups were found on the Auditory Control task only, where non-fluent PWA were more vulnerable to task demands. Correlation analyses found that verbal and non-verbal cognitive control performance was correlated for the non-fluent group, whereas only correlations between verbal cognitive control tasks were significant for the fluent group. For all PWA, non-verbal cognitive control indexed by Flanker interference scores was related to language comprehension, whereas verbal cognitive control was related to picture naming. However, non-verbal relational reasoning as indexed by the Rule Finding task was significantly related to language comprehension in the non-fluent group only. Conclusions: All PWA had diminished verbal cognitive control. Non-fluent PWA demonstrated higher vulnerability to domain-general cognitive control deficits compared to fluent PWA. Performance on verbal and non-verbal cognitive control tasks significantly overlapped in the non-fluent group only. Both groups recruited non-verbal cognitive control during language comprehension and verbal cognitive control during picture naming. Only non-fluent PWA relied on domain-general relational reasoning during language comprehension. These findings reinforce the importance of cognitive assessment in aphasia.
Building New Management Theory by Integrating Processes and Products of Thought

This article advocates that more strategy researchers and managers become engaged in aninteractive, reciprocating research process, the objective of which is building pragmatic strategic management theory. To this purpose, the authors suggest how researchers and managers may engage in theory-building processes in which generalized theories of researchers and contextual theories of managers interactively evolve in a new model of double-loop learning. In particular, the authors suggest the following sequence of activities: (a) Researchers should propose integrative theories thought to be generally applicable; researchers and managers should then consider applicability of strategy theory to specific competitive contexts. (b) This strategic logic is then formulated by managers and applied to specific competitive contexts. (c) The market response leads to refining or to redefining the firm’s strategic logic. (d) The firm’s experience in formulating and in testing strategic logics inform researchers’ efforts to develop new strategy theory.
Robust and Probabilistic Failure-Aware Placement

Motivated by the growing complexity and heterogeneity of modern data centers, and the prevalence of commodity component failures, this paper studies the failure-aware placement problem of placing tasks of a parallel job on machines in the data center with the goal of increasing availability. We consider two models of failures: adversarial and probabilistic. In the adversarial model, each node has a weight (higher weight implying higher reliability) and the adversary can remove any subset of nodes of total weight at most a given bound W and our goal is to find a placement that incurs the least disruption against such an adversary. In the probabilistic model, each node has a probability of failure and we need to find a placement that maximizes the probability that at least K out of N tasks survive at any time. For adversarial failures, we first show that (i) the problems are in Σ2, the second level of the polynomial hierarchy, (ii) a basic variant, that we call RobustFAP, is co-NP-hard, and (iii) an all-or-nothing version of RobustFAP is Σ2-complete. We then give a PTAS for RobustFAP, a key ingredient of which is a solution that we design for a fractional version of RobustFAP. We then study fractional RobustFAP over hierarchies, denoted HierRobustFAP, and introduce a notion of hierarchical max-min fairness/ and a novel Generalized Spreading/ algorithm which is simultaneously optimal for all W. These generalize the classical notion of max-min fairness to work with nodes of differing capacities, differing reliability weights and hierarchical structures. Using randomized rounding, we extend this to give an algorithm for integral HierRobustFAP. For the probabilistic version, we first give an algorithm that achieves an additive ε approximation in the failure probability for the single level version, called ProbFAP, while giving up a (1 + ε) multiplicative factor in the number of failures. We then extend the result to the hierarchical version, HierProbFAP, achieving an ε additive approximation in failure probability while giving up an (L + ε) multiplicative factor in the number of failures, where $L$ is the number of levels in the hierarchy.
Genetic relationships among Hylocereus and Selenicereus vine cacti (Cactaceae): evidence from hybridization and cytological studies.

BACKGROUND AND AIMS Hylocereus and Selenicereus are native to tropical and sub-tropical America. Based on its taxonomic status and crossability relations it was postulated that H. megalanthus (syn. S. megalanthus) is an allotetraploid (2n = 4x = 44) derived from natural hybridization between two closely related diploid taxa. The present work aimed at elucidating the genetic relationships between species of the two genera. METHODS Crosses were performed and the putative hybrids were analysed by chromosome counts and morphological traits. The ploidy level of hybrids was confirmed by fluorescent in situ hybridization (FISH) of rDNA sites. Genomic in situ hybridization (GISH) was used in an attempt to identify the putative diploid genome donors of H. megalanthus and an artificial interploid hybrid. KEY RESULTS Reciprocal crosses among four diploid Hylocereus species (H. costaricensis, H. monacanthus (syn. H. polyrhizus), H. undatus and Hylocereus sp. ) yielded viable diploid hybrids, with regular chromosome pairing. Reciprocal crosses between these Hylocereus spp. and H. megalanthus yielded viable triploid, pentaploid, hexaploid and aneuploid hybrids. Morphological and phenological traits confirm the hybrid origin. In situ detection of rDNA sites was in accord with the ploidy status of the species and hybrid studied. GISH results indicated that overall sequence composition of H. megalanthus is similar to that of H. ocamponis and S. grandiflorus. High sequence similarity was also found between the parental genomes of H. monacanthus and H. megalanthus in one triploid hybrid. CONCLUSIONS The ease of obtaining partially fertile F1 hybrids and the relative sequence similarity (in GISH study) suggest close genetic relationships among the taxa analysed.
Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma

Background: Since 2007 when anaplastic lymphoma kinase (ALK) rearrangements were discovered in non-small cell lung cancer, the ALK gene has received attention due to ALK-targeted therapy, and a notable treatment advantage has been observed in patients harboring the EML4/ALK translocation. However, using ALK-fluorescence in situ hybridization (FISH) as the standard method has demerits such as high cost, a time-consuming process, dependency on interpretation skill, and tissue preparation. We analyzed the histologic findings which could complement the limitation of ALK-FISH test for pulmonary adenocarcinoma. Methods: Two hundred five cases of ALK-positive and 101 of ALK-negative pulmonary adenocarcinoma from January 2007 to May 2013 were enrolled in this study. The histologic findings and ALK immunohistochemistry results were reviewed and compared with the results of ALK-FISH and EGFR/KRAS mutation status. Results: Acinar, cribriform, and solid growth patterns, extracellular and intracellular mucin production, and presence of signet-ring-cell element, and psammoma body were significantly more often present in ALK-positive cancer. In addition, the presence of goblet cell-like cells and presence of nuclear inclusion and groove resembling papillary thyroid carcinoma were common in the ALK-positive group. Conclusions: The above histologic parameters can be helpful in predicting ALK rearranged pulmonary adenocarcinoma, leading to rapid FISH analysis and timely treatment.
Perceptions of Customer Service, Information Privacy, and Product Quality From Semiotic Design Features in an Online Web Store

The rise of the World Wide Web for electronic commerce has led to a proliferation of companies selling products online. The global nature of the Internet allows customers to browse the products of companies with which they are wholly unfamiliar. However, concerns about customer service, information privacy, and product quality discourage purchasing from unknown companies. In this article, the effects of semiotic Web design features on expectations of these performance criteria in a purchase situation are investigated. Specifically, the presence and prominence of links to customer service and a site privacy policy, and the existence of product ratings and customer testimonials, were tested to measure their effects on customer perceptions and expectations. Results indicate that some design features have a strong semiotic effect on customer expectations. Prominent links to customer service and a site privacy policy significantly increased expectations of customer service and privacy protection. The presence of product ratings increased perceptions of product quality. All 3 design features led to increased likelihood of purchase. Furthermore, participants were not aware of these effects and reported not considering product ratings in their decisions. Implications of these results on Web site design and consumer behavior are discussed.
Improving the Post-Editing Experience using Translation Recommendation: A User Study

We report findings from a user study with professional post-editors using a translation recommendation framework (He et al., 2010) to integrate Statistical Machine Translation (SMT) output with Translation Memory (TM) systems. The framework recommends SMT outputs to a TM user when it predicts that SMT outputs are more suitable for post-editing than the hits provided by the TM. We analyze the effectiveness of the model as well as the reaction of potential users. Based on the performance statistics and the users’ comments, we find that translation recommendation can reduce the workload of professional post-editors and improve the acceptance of MT in the localization industry.
The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors

The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance. Premenopausal obese women, aged 35–52 years, were studied. GH secretion, IGF-I, serum cardiovascular risk markers, insulin, leptin, mid-waist and hip circumference, total body fat, and truncal fat were measured. Subjects were classified as meeting the criteria for GH deficiency (GHD) when peak GH after stimulation with GHRH was ≤3 μg/L. Mean total and LDL cholesterol, fasting insulin, and HOMA-IR were all higher, in subjects who would have been classified as GH-deficient compared with GH-sufficient. Peak GH secretion after stimulation was inversely associated with fasting insulin (R = −0.650, P = .012), HOMA-IR (R = −0.846, P = .001), total cholesterol (R = −0.532, P = .034), and LDL cholesterol (R = −0.692, P = .006) and positively associated with HDL cholesterol (R = 0.561, P = .037). These data strongly suggest a role for insulin resistance in the decreased GH secretion of obesity and that the blunted GH secretion of central obesity could be the pituitary expression of the metabolic syndrome.
Efficiencies of Low-Mass Star and Star Cluster Formation

Using a quantitative model for bipolar outflows driven by hydromagnetic protostellar winds, we calculate the efficiency of star formation assuming that available gas is either converted into stars or ejected in outflows. We estimate the efficiency of a single star formation event in a protostellar core, finding 25%-70% for cores with various possible degrees of flattening. The core mass function and the stellar initial mass function have similar slopes because the efficiency is not sensitive to its parameters. We then consider the disruption of gas from a dense molecular clump in which a cluster of young stars is being born. In both cases, we present analytical formulae for the efficiencies that compare favorably against observations and, for clusters, against numerical simulations. We predict efficiencies in the range of 30%-50% for the regions that form clusters of low-mass stars. In our model, star formation and gas dispersal happen concurrently. We neglect the destructive effects of massive stars: our results are therefore upper limits to the efficiency in regions more massive than about 3000 M☉ .