Miracle-dz/UniFAR-FTUs huggingface dataset:
Uncontrolled hypertension and orthostatic hypotension in relation to standing balance in elderly hypertensive patients

Objective To investigate the associations among uncontrolled hypertension, orthostatic hypotension (OH), and standing balance impairment in the elderly hypertensive patients referred to comprehensive geriatric assessment (CGA). Methods In a cross-sectional study, a total of 176 elderly hypertensive patients who underwent CGA were divided into OH group (n=36) and non-OH group (n=140) according to blood pressure measurement in the supine position, after immediate standing up, and after 1 minute and 3 minutes of standing position. Uncontrolled hypertension was defined as blood pressure of ≥140/90 mmHg if accompanied by diabetes mellitus (DM) or chronic kidney disease (CKD), or ≥150/90 mmHg if no DM and no CKD. Standing balance, including immediate standing balance and prolonged standing balance, was assessed in side-by-side and tandem stance. Results Neither uncontrolled hypertension nor OH was associated with prolonged standing balance impairment in elderly hypertensive patients (P>0.05). Blood pressure decrease after postural change was significantly associated with immediate standing balance impairment in side-by-side and tandem stance (P<0.05). Patients with OH were at greater risk of immediate standing balance impairment in both side-by-side and tandem stance than those without OH (odds ratio [OR] 3.44, 95% confidence interval [CI] 1.26–9.33, P<0.05; OR 3.14, 95% CI 1.14–8.64, P<0.01). Furthermore, uncontrolled hypertension was associated with immediate standing balance impairment in side-by-side stance (OR 2.96, 95% CI 1.31–6.68, P<0.05). Conclusion Uncontrolled hypertension, OH, and blood pressure decrease after postural change were associated with immediate standing balance impairment, and therefore, a better understanding of the underlying associations might have major clinical value.
Expression of Natural Autoantibodies in MRL-lpr Mice Protects from Lupus Nephritis and Improves Survival

Natural autoantibodies (NAA) and their associated B cells constitute a substantial proportion of the normal Ab and B cell repertoire. They often have weak reactivity toward a variety of self-Ags such as DNA, nucleoproteins, and phospholipids. It remains controversial whether NAA contribute to or protect from autoimmune diseases. Using site-directed transgenic (sd-tg) mice expressing a prototypic NAA, we investigated the effect of NAA and NAA-producing B cells in disease development in the autoimmune-prone MRL/MpJ-Faslpr (MRL-lpr) mice. We found that the expression of NAA in MRL-lpr mice prevented proteinuria and reduced kidney immune complex formation. The mice had significantly improved survival. Administration of the IgM NAA to MRL-lpr mice also delayed the onset of nephritis. The sd-tg MRL-lpr mice had decreased levels of anti-dsDNA Abs, anti-Hep2 nuclear Abs, and anti-Sm/ribonucleoprotein Abs. There is a shift in the IgG subclass profile from IgG2a and IgG3 to IgG1 in the sd-tg MRL-lpr mice. The CD4+ T cells from the sd-tg MRL-lpr mice had increased expression of the negative costimulatory molecule CTLA-4 and increased production of IL-10 as compared with those from the wild-type mice. Furthermore, the NAA B cells produced large amounts of IL-10 upon TLR stimulation. These results indicate that NAA and NAA-producing B cells play an important role in protection from lupus nephritis and suggest that the NAA B cells may have an immune regulatory function via the provision of IL-10.
Epidemiology and changed surgical treatment methods for fractures of the distal radius

Background and purpose The incidence of fractures of the distal radius may have changed over the last decade, and operative treatment has been commoner during that time. We investigated the incidence of fractures of the distal radius and changing trends in surgical treatment during the period 2004–2010. Patients and methods Registry data on 42,583 patients with a fracture of the distal radius from 2004 to 2010 were evaluated regarding diagnosis, age, sex, and surgical treatment. Results The crude incidence rate was 31 per 104 person-years with a bimodal distribution. After the age of 45 years, the incidence rate in women increased rapidly and leveled off first at a very high age. The incidence rate in postmenopausal women was lower than previously reported. In men, the incidence was low and it increased slowly until the age of 80 years, when it amounted to 31 per 104 person-years. The number of surgical procedures increased by more than 40% despite the fact that there was reduced incidence during the study period. In patients ≥ 18 years of age, the proportion of fractures treated with plating increased from 16% to 70% while the use of external fixation decreased by about the same amount. Interpretation The incidence rate of distal radius fractures in postmenopausal women appears to have decreased over the last few decades. There has been a shift in surgical treatment from external fixation to open reduction and plating.
The escaped and trapped emission in organic light-emitting devices

The escaped and trapped emission of organic light-emitting diodes was investigated by an integrating sphere and a fiber spectrometer. It was found that the ratio of escaped emission to the escaped and trapped in the substrate emission is 71%. In order to explain our experimental results, we extended the half-space dipole model, in which the dipole radiation pattern is taken into account. The calculated escaped and trapped emission of devices agreed well with our experiments. Our experimental and theoretical results is expected to be an instruction to the optimization of device structures for improving the out-coupling efficiency.
Nucleotide sequence analysis of the trimethoprim resistant dihydrofolate reductase encoded by R plasmid R751.

Not AM SMu ELs Asa sAm Sly Va1 38r 7h Lou Vol Ala Sly Mur Pb. Ala Lou Pr. 3w lAs Ala Thr Ph. Sly4 ATTCAC AAOAOTCAAT ATO OAC CAA CAC AAC UT GOA OTC ACT ACT CTA OTT OCT OOC CAO TTT OCO CTT CCA TCO CAC OCC ACO TTT GOC ATTCACAAUOAAATTCOAC ATO OGT CAA AOT AOC OAT OAA 0CC AAC OCT CCC OT OCA 000 CAO TTT OCG CTT CCC CTO ACT 0CC ACC TTT GOC 540 Lou O1y Amp irg Vol AM Lys Lys Sw Sy Ala Ala Tap Os Sly Sl Vol Vol 51y Tap Tyr Lys Tha LysL Pro Mu Sy TYr CTO OGA OAT COC OTC Coc AaO AA TCT OOC 0CC OCT TOO CAO OOT CAA OTT OTC 000 TOO TAC TOC ACA AAA CTO ACC CCT OAA oGC TAT TTA 000 OAT COC OTA Coc AAO AU TCT OCT 0CC OCT TOO CAO SOT CAA OTC OTC SOT TOO TAT TOC ACA AAA CTC ACT CCT OAA OOC TAT
The role of sensory dysfunction in the development of voice disorders, chronic cough and paradoxical vocal fold movement

Sensory function may be important in the pathogenesis of Chronic Cough (CC) and Paradoxical Vocal Fold Movement (PVFM). This paper aims to explore sensory issues related to the pathogenesis, classification, assessment and management of these conditions. Sensory disruption of the vagus nerve can occur through neural plasticity whereby a change occurs in the way a central neuron reacts to an incoming stimulus. Such disruption can be demonstrated through assessment of cough reflex sensitivity and extrathoracic airway hyperresponsiveness both of which may be increased in CC and PVFM. In addition, sensory function may be determined by measuring the laryngeal adductor reflex, however this phenomenon is yet to be explored in CC and PVFM. The similarity in sensory dysfunction between CC and PVFM provides support for a link between the two conditions. There are also similarities in underlying medical conditions and symptom profiles between CC/PVFM and voice disorders such as muscle tension dysphonia. Although coughing and throat clearing may be contributing factors in the development and maintenance of voice disorders, they may occur in response to extrathoracic airway hyperresponsiveness. Dysphonia can occur in CC/PVFM and may improve following behavioural treatment of CC.
MORPHOLOGIC AND MORPHOMETRIC ANALYSIS OF THE ROOT CANAL APICAL THIRD CLEANING AFTER BIOMECHANICAL PREPARATION USING 3.3% RICINUS COMMUNIS DETERGENT AND 1% NaOCL AS IRRIGATING SOLUTIONS

This study evaluated, by morphologic and morphometric analyses, the cleaning of apical third of root canals instrumented with nickel-titanium rotary files using different irrigating solutions. Twenty-seven single-rooted mandibular premolars were assigned to three groups (n=9), according to the irrigating solution used: Group I, distilled and deionized water; Group II, 1% NaOCl; and Group III, 3.3% Ricinus communis detergent. Biomechanical preparation was performed with Protaper Plusâ nickel-titanium files as follows: S1, SX and S2 at the cervical and middle thirds, and 25/02, 25/04, 25/06, 30/02, 30/04 and 30/06 to complete the instrumentation, operating at 1 mm from the root apex. Irrigation was done at each file change with 2 mL of irrigating solution, totalizing 20 mL for each tooth. After biomechanical preparation, the apical thirds were serially sectioned and histologically processed. The cross-sections were examined by an optical microscope (X40) connected to a computer. The images were captured and analyzed using a computer software and submitted to morphometric analysis with aid of a grid. The percentage of debris remaining at the apical third was calculated. Data were submitted to statistical analysis by ANOVA and Tukey test. The results showed no statistically significant difference (p>0.01) between the groups irrigated with 1% NaOCl and 3.3% Ricinus communis detergent, which presented the lowest percentage of debris at the apical third, 8.49% and 10.11%, respectively. The group irrigated with distilled and deionized water had the highest percentage of debris (15.58%) and was statistically different from the other groups (p<0.01). It may be concluded that 3.3% Ricinus communis detergent and 1% NaOCl had similar cleaning effectiveness on removal of debris from root canals.
Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome

Abstract We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)–1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS.
THE FORMAL DEFINITION OF REFERENCE PRIORS

Reference analysis produces objective Bayesian inference, in the sense that inferential statements depend only on the assumed model and the available data, and the prior distribution used to make an inference is least informative in a certain information-theoretic sense. Reference priors have been rigorously defined in specific contexts and heuristically defined in general, but a rigorous general definition has been lacking. We produce a rigorous general definition here and then show how an explicit expression for the reference prior can be obtained under very weak regularity conditions. The explicit expression can be used to derive new reference priors both analytically and numerically.
Subjective social status and its relationship to health and health behavior: comparing two different scales in university students

Abstract Background Little is known about the relationship between socioeconomic status (SES) and health in late adolescence. As it is difficult to measure SES in this age group directly, we used two subjective social status (SSS) scales with different reference groups for social comparison in the relatively homogeneous group of university students and analyzed the relationship with health and health behaviors. Methods We used two 10-rung ladders, a societal and a university one, to measure SSS in students (n = 689, 16–29 years). We compared the scales’ ratings and analyzed relationships with sociodemographic factors, health outcomes and behaviors. Results On average, students rated their individual SSS higher on the university scale (6.87) than on the societal one (6.41). Regarding health outcomes and behaviors, we found similar results for both scales, while sociodemographic variables were more likely to be associated with the societal scale. Conclusion SSS seems to be a useful measure besides the objective SES. Our data suggest that both SSS scales are helpful in the framework of health inequality but differ slightly in what they measure. More detailed research may help to determine which scale is appropriate for individual study context.
Author ' s personal copy Losing sight of oneself in the above-average effect : When egocentrism , focalism , and group diffuseness collide q

Four experiments examined the relative influence of three causal processes in the above-average effect (AAE) and related comparative biases: (a) egocentrism, (b) focalism, and (c) referent group diffuseness. By manipulating the inclusion or exclusion of the self from the referent group (Experiments 1–3) or target group (Experiment 4), the relative contributions of each influence were assessed. In direct comparisons, single peers were systematically judged more favorably relative to groups including the self, suggesting that egocentrism plays a lesser role than focalism or group diffuseness. Thus, in response to the question such as ‘‘How friendly is Nancy compared to the rest of us? ” the answer tends to be ‘‘More friendly. ” 2008 Elsevier Inc. All rights reserved.
Estimating the Cost of Capital Through Time: An Analysis of the Sources of Error

Practitioners needing estimates of a firmÂ¹s equity cost of capital have long relied on the Capital Asset Pricing Model (CAPM). Recent evidence casts renewed doubt on the validity of the CAPM and beta. However, there is not much evidence to gauge the importance of the rejections of the CAPM in a practical decision-making context. This paper presents evidence on the sources of error in estimating required returns over time. We use a number of proxies for the true mean variance efficient portfolio, allowing that the CAPM is the "wrong" model. The analyst is assumed to rely on a standard market index. We find that the great majority of the error in estimating the cost of equity capital is found in the risk premium estimate, and relatively small errors are due to the risk measure, or beta. This suggests that analysts should improve estimation procedures for market risk premiums, which are commonly based on historical averages. This can be done by using regression models, such as have appeared in the recent finance literature, or by purchasing forecasts from firms that specialize in producing them.
Electron Beam Freeform Fabrication (EBF3) for Cost Effective Near-Net Shape Manufacturing

Manufacturing of structural metal parts directly from computer aided design (CAD) data has been investigated by numerous researchers over the past decade. Researchers at NASA Langley Research Center are developing a new solid freeform fabrication process, electron beam freeform fabrication (EBF3), as a rapid metal deposition process that works efficiently with a variety of weldable alloys. EBF3 deposits of 2219 aluminium and Ti-6Al-4V have exhibited a range of grain morphologies depending upon the deposition parameters. These materials have exhibited excellent tensile properties comparable to typical handbook data for wrought plate product after post-processing heat treatments. The EBF3 process is capable of bulk metal deposition at deposition rates in excess of 2500 cubic centimeters per hour (150 in3/hr) or finer detail at lower deposition rates, depending upon the desired application. This process offers the potential for rapidly adding structural details to simpler cast or forged structures rather than the conventional approach of machining large volumes of chips to produce a monolithic metallic structure. Selective addition of metal onto simpler blanks of material can have a significant effect on lead time reduction and lower material and machining costs.
CIRCUMSPECTUS MEDICINAE : TEXT AND CONTEXT The Quality of Rhinoplasty Health Information on the Internet

Background: Patients considering rhinoplasty often use internet health information resources before consultation with a surgeon. These can be beneficial and promote patient autonomy if high quality or be detrimental if misleading impressions about results and complications are reported as fact. This study aimed to objectively assess the quality of health information regarding rhinoplasty on the internet. Methods: The 3 most popular search engines in the United Kingdom (Google, Bing, and Yahoo) were searched using 4 different terms relating to rhinoplasty. The first 30 links from each searchwere collated; 360 links in totalwere screened. Sixty-six suitable websites were examined using the LIDA and DISCERN instruments and had their Flesch Reading Ease Scores (FRES) calculated. Results: The websites displayed low LIDA reliability scores (22%), moderate usability (61%) and high accessibility scores (87%). There was no correlation between a website's search result rank and its LIDA score (Spearman ρ = 0.033, P = 0.799). The DISCERN scores were generally low (mean 54%) and displayed no correlation with website rank (Spearman ρ = 0.070, P = 0.564). FRES values were less readable than that recommended for health information (mean FRES = 57.8; recommended ≥70) and significantly correlated with website rank (Spearman ρ = −0.3164; P = 0.009). Conclusions: Rhinoplasty internet health information is generally of low quality, unreliable and less readable than recommended. Improvements are needed to increase the quality of internet rhinoplasty resources for patients.
Purchase Intention of Apparel Brand: Influence of Social Media and Learning Style

The present study attempts to investigate the relations between the communications on the social network platforms and its effect on the purchase intentions of the consumers and more specifically the young adolescents. Further, this study also attempts to investigate how these relationships vary across young people possessing different learning styles. This study analysed the data in three part. The initial was an exploratory study which consisted of maintaining and excluding those items which enabled the analysis of other dimensions or factors with a suitable degree of reliability or uni-dimensionality. The second part was an exploratory and confirmatory factor analysis and the third being the structural equation modelling, which discarded those items which did not enable suitable dimensionality for the entire construct in the model. Confirmatory Factor Analysis (CFA) and Structural Equation Modelling (SEM) was used to test the present model using AMOS 21 software and basic calculations in statistics such as mean, standard deviation, factor analysis, correlation will be performed using SPSS 21. The study shows that the social media communication influence brand attitude and image leading to purchase intention.
Effect of addition ZrO2-Al2O3 nanoparticles mixture on some properties and denture base adaptation of heat cured acrylic resin denture base material

The PMMA polymer denture base materials are low mechanical properties, adaptation of the denture base to underlying tissue is important for retention and stability of denture. The aim of the study was toevaluate the effect of mixtureZrO2-Al2O3 nanoparticles on impact strength, transverse strength, hardness, roughness, denture base adaptation of heat cured acrylic resin denture base material. Materials and methods: One hundred (100) specimens were prepared, the specimens were divided into five groups (20 specimens to each) according to the test type, each group was subdivided in to two subgroups (control and experimental) each subgroup consist of 10 specimens, the experimental group included mixture of 2% (ZrO 2- Al2O3ratio2:1) by weight. Theimpact strength was measured by Charpy's impact testing machine, the transverse strength was measured by Instron testing machine while the hardness was measured byshore D durometer and roughness was measured by Profilometer. Denture base adaptation was measured by digital microscope and evaluated by computerized tomography (CT). Results: Highly significant increaseofimpact and transverse strength, non-significant increase ofhardness, significant increase ofroughness andreduction of denture base adaptation (measured at 3 point A, B and C) occurred in experimental groupwhen compared to control group. CT evaluation, gap between the denture base and master cast (control and experimental groups) increased from the anterior to posterior side of palate and from the alveolar ridge to the mid palatal line. Conclusion: The polymer nanocomposites had mechanical properties higher than neat PMMA at same time less
EVALUATION OF CRUSHING IN GRANULAR MATERIALS USING THE DISCRETE ELEMENTMETHOD AND FRACTAL THEORY

Granular materials forming part of embankments, foundations, pavement structures, and rail trackstructures are subjected to both static and dynamic loads. As a result of these loads particle breakage may occur. Particle breakage causes settlements and a reduction in the hydraulic conductivity of the granularmaterial. Moreover, the elastic modulus and the shear strength of the granular material are also negatively affected. Granular crushing is a detrimental phenomenon that deserves to be sudied in order to understand its causes, consequences, and ways to avoid it. Laboratory tests conducted on a weak granular material (sugar) and computer simulations (in the form of the Discrete Element Method, DEM) were usedto visualize, analyze, and understand the evolution of crushing in granular materials. The original DEM was modified to include the possibility of particle fragmentation. A tensile failure criterion developed by the author was programmed and incorporated into a commercial DEM code (PFC2D). The breakage model was also used to study the evolution of crushing in practical geotechnical applications. Fractal theory was used to quantify the amount of crushing produced under different conditions of stress and strain. In particular, the fragmentation fractal dimension was used to describe the changes on the grain sizedistribution of the analyzed materials.
Effect of daily sildenafil on patients with absent nocturnal erections due to pelvic fracture urethral disruption: a single‐centre experience

Erectile dysfunction (ED) is a common sequel of pelvic fracture urethral disruption. Those patients with nocturnal erections may respond favourably to sildenafil; however, little is known about the response to sildenafil in patients with absent nocturnal erections. The aim was to evaluate the response to the treatment of sildenafil 50 mg taken once daily in the patients with absent nocturnal erections. From January 2008 to December 2011, a total of 28 patients with absent nocturnal erections were evaluated. We recorded nocturnal penile tumescence and rigidity with an erectometer. If nocturnal erections were absent for three nights, patients were administrated sildenafil 100 mg at bedtime and tested again at the fourth night. Penile duplex ultrasound with intracavernous injection was performed to define the cause of ED. All patients received a daily dose of sildenafil 50 mg for 12 weeks. Response to sildenafil treatment was defined as sustained erections allowing vaginal penetration and intercourse. Twenty‐three (78%) patients completed the daily sildenafil treatment, and follow‐up was available. The nocturnal erections at the fourth night in 13 patients (46.4%) were improved. About 61.5% (8/13) reported effective response to daily sildenafil. The improvement of nocturnal erections induced by sildenafil taken at bedtime might predict the response to sildenafil taken daily.