Miracle-dz/UniFAR-FTUs huggingface dataset:
An Ultra-Wideband IF Millimeter-Wave Receiver With a 20 GHz Channel Bandwidth Using Gain-Equalized Transformers

This paper presents a CMOS millimeter-wave (mm-wave) receiver designed to meet the challenges in low-power, ultra-broadband, phased-array systems with a large number of array elements. This receiver employs a high intermediatefrequency (IF) heterodyne architecture to reduce the frequency and power consumption associated with distributing a local oscillator (LO). The receiver operates over a bandwidth of 51-71 GHz, while maintaining 20 GHz of bandwidth along the signal chain of the entire mm-wave front end, through a high-IF stage, and to the baseband output. To maintain a high fractional bandwidth (fBW) throughout the signal chain, this receiver employs multiple gainequalized transformers. Receiver measurements show an overall flat bandwidth response of 20 GHz, with a total gain of 20 dB, a minimum double-sideband noise figure of 7.8 dB, and an input 1 dB compression power of -24 dBm while consuming 115 mW from a 1.1 V supply. The test chip, implemented in a six-metal layer 40 nm CMOS process, occupies an area (including pads) of 1.2 mm2.
Changes to the structure of Sphingomonas spp. communities associated with biodegradation of the herbicide isoproturon in soil.

The phenyl-urea herbicide isoproturon is a major contaminant of surface and ground-water in agricultural catchments. Earlier work suggested that within-field spatial variation of isoproturon degradation rate resulted from interactions between catabolizing Sphingomonas spp. and pH. In the current study, changes to the structure of Sphingomonas communities during isoproturon catabolism were investigated using Sphingomonas-specific 16S rRNA gene primers. Growth-linked catabolism at high-pH (>7.5) sites was associated with the appearance of multiple new denaturing gradient gel electrophoresis (DGGE) bands. At low-pH sites, there was no change in DGGE banding at sites in which there was cometabolism, but at sites in which there was growth-linked catabolism, degradation was associated with the appearance of a new band not present at high pH sites. Sequencing of DGGE bands indicated that a strain related to Sphingomonas mali proliferated at low pH sites, while strain Sphingomonas sp. SRS2, a catabolic strain identified in earlier work, together with several further Sphingomonas spp. , proliferated at high-pH sites. The data indicate that degradation was associated with complex changes to the structure of Sphingomonas spp. communities, the precise nature of which was spatially variable.
Bounding a Linear Causal Effect Using Relative Correlation Restrictions

Abstract This paper describes and implements a simple partial solution to the most common problem in applied microeconometrics: estimating a linear causal effect with a potentially endogenous explanatory variable and no suitable instrumental variables. Empirical researchers faced with this situation can either assume away the endogeneity or accept that the effect of interest is not identified. This paper describes a middle ground in which the researcher assumes plausible but nontrivial restrictions on the correlation between the variable of interest and relevant unobserved variables relative to the correlation between the variable of interest and observed control variables. Given such relative correlation restrictions, the researcher can then estimate informative bounds on the effect and assess the sensitivity of conventional estimates to plausible deviations from exogeneity. Two empirical applications demonstrate the potential usefulness of this method for both experimental and observational data.
Aniseikonia in relation to strabismus, anisometropia and amblyopia.

PURPOSE To study the interrelationships among these four entities which are critical to binocular vision and its precision. SUBJECTS AND METHODS 102 selected patients (for their ability to have stereoscopic depth perception, a requisite for space eikonometry) were evaluated. Patient testing included stereoscopic testing, Essilor Projection Space Eikonometry, ultrasonic echographic axial length measurements and orthoptic evaluation. Aniseikonia was measured on the Essilor Projection Space Eikonometer. RESULTS 1. Anisometropia alone was correlated with a marked increase in amblyopia, a moderate increase in aniseikonia and no noteworthy increase in strabismus. Statistical analysis (chi square ratio) showed that persons with elevated anisometropic values had a 4.4 fold increased risk of aniseikonia (p=.003). 2. Aniseikonia alone was not responsible for marked variations in strabismus. 3. Amblyopia was correlated with increases in anisometropia and aniseikonia. 4. Adding aniseikonia to anisometropia produced a possible increase in strabismus and a great increase in amblyopia (using Fisher's Exact Test, 2-tailed). 5. Spearman correlations of the "absolute values" (the mean of the mathematical difference between the two eyes of anisometropia and amblyopia) were as follows: anisometropia (abs) vs. aniseikonia r=. 294, p=. 006; anisometropia (abs) vs. amblyopia (abs) 4=. 555, p=<. 001; amblyopia (abs) vs. aniseikonia r=. 234, p=. 02. CONCLUSIONS Aniseikonia per se does not appear to have a major causal role in amblyopia or strabismus, but anisometropia does for amblyopia. This role is greatly augmented by aniseikonia and this combination may then produce strabismus.
The Prethalamus Is Established during Gastrulation and Influences Diencephalic Regionalization

The vertebrate neural plate contains distinct domains of gene expression, prefiguring the future brain areas. In this study, we draw an extended expression map of the rostral neural plate that reveals discrete domains inside the presumptive posterior forebrain. We show, by fate mapping, that these well-defined cell populations will develop into specific diencephalic regions. To address whether these early subterritories are already committed to restricted identities, we began to analyse the consequences of ablation and transplantation of these specific cell populations. We found that precursors of the prethalamus are already specified and irreplaceable at late gastrula stage, because ablation of these cells results in loss of prethalamic markers. Moreover, when transplanted into the ectopic environment of the presumptive hindbrain, these cells still pursue their prethalamic differentiation program. Finally, transplantation of these precursors, in the rostral-most neural epithelium, induces changes in cell identity in the surrounding host forebrain. This cell–non-autonomous property led us to propose that these committed prethalamic precursors may play an instructive role in the regionalization of the developing diencephalon.
Passive mechanical properties of rat abdominal wall muscles suggest an important role of the extracellular connective tissue matrix

Abdominal wall muscles have a unique morphology suggesting a complex role in generating and transferring force to the spinal column. Studying passive mechanical properties of these muscles may provide insights into their ability to transfer force among structures. Biopsies from rectus abdominis (RA), external oblique (EO), internal oblique (IO), and transverse abdominis (TrA) were harvested from male Sprague–Dawley rats, and single muscle fibers and fiber bundles (4–8 fibers ensheathed in their connective tissue matrix) were isolated and mechanically stretched in a passive state. Slack sarcomere lengths were measured and elastic moduli were calculated from stress–strain data. Titin molecular mass was also measured from single muscle fibers. No significant differences were found among the four abdominal wall muscles in terms of slack sarcomere length or elastic modulus. Interestingly, across all four muscles, slack sarcomere lengths were quite long in individual muscle fibers (>2.4 µm), and demonstrated a significantly longer slack length in comparison to fiber bundles (p < 0.0001). Also, the extracellular connective tissue matrix provided a stiffening effect and enhanced the resistance to lengthening at long muscle lengths. Titin molecular mass was significantly less in TrA compared to each of the other three muscles (p < 0.0009), but this difference did not correspond to hypothesized differences in stiffness. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1321–1326, 2012
Wireless Neck-Surface Accelerometer and Microphone on Flex Circuit with Application to Noise-Robust Monitoring of Lombard Speech

Ambulatory monitoring of real-world voice characteristics and behavior has the potential to provide important assessment of voice and speech disorders and psychological and emotional state. In this paper, we report on the novel development of a lightweight, wireless voice monitor that synchronously records dual-channel data from an acoustic microphone and a necksurface accelerometer embedded on a flex circuit. In this paper, Lombard speech effects were investigated in pilot data from four adult speakers with normal vocal function who read a phonetically balanced paragraph in the presence of different ambient acoustic noise levels. Whereas the signal-to-noise ratio (SNR) of the microphone signal decreased in the presence of increasing ambient noise level, the SNR of the accelerometer sensor remained high. Lombard speech properties were thus robustly computed from the accelerometer signal and observed in all four speakers who exhibited increases in average estimates of sound pressure level (+2.3 dB), fundamental frequency (+21.4 Hz), and cepstral peak prominence (+1.3 dB) from quiet to loud ambient conditions. Future work calls for ambulatory data collection in naturalistic environments, where the microphone acts as a sound level meter and the accelerometer functions as a noise-robust voicing sensor to assess voice disorders, neurological conditions, and cognitive load.
Maastricht Delphi consensus on event definitions for classification of recurrence in breast cancer research.

BACKGROUND In breast cancer studies, many different endpoints are used. Definitions are often not provided or vary between studies. For instance, "local recurrence" may include different components in similar studies. This limits transparency and comparability of results. This project aimed to reach consensus on the definitions of local event, second primary breast cancer, regional and distant event for breast cancer studies. METHODS The RAND-UCLA Appropriateness method (modified Delphi method) was used. A Consensus Group of international breast cancer experts was formed, including representatives of all involved clinical disciplines. Consensus was reached in two rounds of online questionnaires and one meeting. RESULTS Twenty-four international breast cancer experts participated. Consensus was reached on 134 items in four categories. Local event is defined as any epithelial breast cancer or ductal carcinoma in situ (DCIS) in the ipsilateral breast, or skin and subcutaneous tissue on the ipsilateral thoracic wall. Second primary breast cancer is defined as epithelial breast cancer in the contralateral breast. Regional events are breast cancer in ipsilateral lymph nodes. A distant event is breast cancer in any other location. Therefore, this includes metastasis in contralateral lymph nodes and breast cancer involving the sternal bone. If feasible, tissue sampling of a first, solitary, lesion suspected for metastasis is highly recommended. CONCLUSION This project resulted in consensus-based event definitions for classification of recurrence in breast cancer research. Future breast cancer research projects should adopt these definitions to increase transparency. This should facilitate comparison of results and conducting reviews as well as meta-analysis.
Topologies on types: connections

For different purposes, economists may use different topologies on types. We char- acterize the relationship among these various topologies. First, we show that for any general types, convergence in the uniform-weak topology implies convergence in both the strategic topology and the uniform strategic topology. Second, we explicitly con- struct a type which is not the limit of any finite types under the uniform strategic topology, showing that the uniform strategic topology is strictly fi ner than the strategic topology. With these results, we can linearly rank various topologies on the universal type space, which gives a clear picture of the relationship between the implication of types for beliefs and their implication for behaviors.
Binding of Soluble Yeast β-Glucan to Human Neutrophils and Monocytes is Complement-Dependent

The immunomodulatory properties of yeast β-1,3/1,6 glucans are mediated through their ability to be recognized by human innate immune cells. While several studies have investigated binding of opsonized and unopsonized particulate β-glucans to human immune cells mainly via complement receptor 3 (CR3) or Dectin-1, few have focused on understanding the binding characteristics of soluble β-glucans. Using a well-characterized, pharmaceutical-grade, soluble yeast β-glucan, this study evaluated and characterized the binding of soluble β-glucan to human neutrophils and monocytes. The results demonstrated that soluble β-glucan bound to both human neutrophils and monocytes in a concentration-dependent and receptor-specific manner. Antibodies blocking the CD11b and CD18 chains of CR3 significantly inhibited binding to both cell types, establishing CR3 as the key receptor recognizing the soluble β-glucan in these cells. Binding of soluble β-glucan to human neutrophils and monocytes required serum and was also dependent on incubation time and temperature, strongly suggesting that binding was complement-mediated. Indeed, binding was reduced in heat-inactivated serum, or in serum treated with methylamine or in serum reacted with the C3-specific inhibitor compstatin. Opsonization of soluble β-glucan was demonstrated by detection of iC3b, the complement opsonin on β-glucan-bound cells, as well as by the direct binding of iC3b to β-glucan in the absence of cells. Binding of β-glucan to cells was partially inhibited by blockade of the alternative pathway of complement, suggesting that the C3 activation amplification step mediated by this pathway also contributed to binding.
A Promising Approach to Narrowing the School-to-Prison Pipeline

Recent dramatic increases in the number of youth arrested for nonserious behavior in schools have led some jurisdictions to search for solutions to the “school-to-prison pipeline. ” In this article, we evaluate the WISE arrest diversion program in Utica, New York. We use a mixed-methods evaluation design including: (1) a pre–post program comparison of school conduct by participants, (2) a pre–post program comparison of school-based arrests at Upstate High School, (3) a multivariate analysis that estimates the influence of the WISE program on school-based arrests while controlling for citywide juvenile arrests and the passage of time, and (4) interviews conducted with students, program staff, and stakeholders. Although the program appeared more successful in reducing Upstate High School’s reliance on arrest than in improving school conduct among participants, results suggest that the WISE arrest diversion program contains promising elements and lessons for narrowing the school-to-prison pipeline.
Development of Accident Modification Factors for Rural Frontage Road Segments in Texas Using Generalized Additive Models

The objective of this study consists of assessing the application of generalized additive models (GAMs) for estimating accident modification factors (AMFs). GAMs are a new type of models that have been recently introduced by the statistical community for modeling observed data. These models offer more flexible functional forms than traditional generalized linear models and allow for more adaptable variable interactions. As recently documented in the literature, variable interactions should be included in the development of AMFs. To accomplish the study objective, AMFs were derived from GAMs using data collected on rural frontage roads in Texas. The AMFs were then compared to the AMFs produced from a previous study using the same data set. The results of the study show that AMFs produced from GAMs are more flexible to characterize the safety effect of simultaneous changes in geometric and operational features (or variable interactions) than when independent AMFs are applied together. The results also show that GAMs indicated a nonlinear relationship between crash risk and changes in lane and shoulder widths for frontage roads in Texas.
Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation.

The AUG-dependent formation of an 80 S ribosomal initiation complex was studied using purified rabbit reticulocyte initiation factors radiolabeled by reductive methylation. The radiolabeled initiation factors were as biologically active as untreated factors. Reaction mixtures containing a variety of components (AUG, GTP, Met-tRNAf, initiation factors, and 40 S and 60 S ribosomal subunits) were incubated at 30 degrees C and then analyzed on linear sucrose gradients for the formation of ribosomal complexes. The results show that both eukaryotic initiation factor (eIF)-3 and the ternary complex (eIF-2.GTP.Met-tRNAf) bind independently to the 40 S subunit and each of these components enhances the binding of the other. All of the polypeptides of eIF-2 and eIF-3 participate in this binding. Formation of an 80 S ribosomal complex requires eIF-5 and 60 S subunits in a reaction that is stimulated by eIF-4C. Both eIF-2 and eIF-3 are released from the 40 S preinitiation complex during formation of the 80 S initiation complex. Release of eIF-2 and eIF-3 does not occur and 80 S ribosomal complexes are not formed if GTP is replaced by a nonhydrolyzable analog such as guanosine 5'-O3-(1,2-mu-imido)triphosphate. Despite a variety of attempts, it has not yet been possible to demonstrate binding of eIF-4C, eIF-4D, or eIF-5 to either 40 S or 80 S ribosomal complexes.
Disruption of nNOS‐PSD95 protein–protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

Background and purpose: Post‐synaptic density protein 95 (PSD95) contains three PSD95/Dosophilia disc large/ZO‐1 homology domains and links neuronal nitric oxide synthase (nNOS) with the N‐methyl‐D‐aspartic acid (NMDA) receptor. This report assesses the effects of disruption of the protein–protein interaction between nNOS and PSD95 on pain sensitivity in rodent models of hyperalgesia and neuropathic pain.
An alternative extension of the k-means algorithm for clustering categorical data

Most of the earlier work on clustering has mainly been focused on numerical data whose inherent geometric properties can be exploited to naturally define distance functions between data points. Recently, the problem of clustering categorical data has started drawing interest. However, the computational cost makes most of the previous algorithms unacceptable for clustering very large databases. The k-means algorithm is well known for its efficiency in this respect. At the same time, working only on numerical data prohibits them from being used for clustering categorical data. The main contribution of this paper is to show how to apply the notion of “cluster centers” on a dataset of categorical objects and how to use this notion for formulating the clustering problem of categorical objects as a partitioning problem. Finally, a k-means-like algorithm for clustering categorical data is introduced. The clustering performance of the algorithm is demonstrated with two well-known data sets, namely, soybean diseaseand nursery databases.
A Longitudinal Study of the Development of Low Back Pain in an Industrial Population

Study Design. This is a longitudinal study in which industrial workers without chronic low back pain (LBP) were initially assessed with a comprehensive test battery and surveyed every 6 months thereafter for 2 years. Objective. To determine factors that may predispose industrial workers who lift over 5000 kg per shift to LBP. Summary of Background Data. Prospective studies are small in number and often limited in breadth or depth of the test battery, methodologic issues, or investigator expertise. There are no prospective studies that focus on a homogeneous work sample of industrial employees. Methods. Production workers (n = 149) who volunteered for the 2-year study were assessed using physical measures (e.g., muscular strength, endurance, and flexibility), lifting kinematics (a sagittal plane box lift), and health, lifestyle, and work environment data (paper questionnaires). Follow-up questionnaires were distributed every 6 months for 2 years. Results. Using self-report of LBP as the main outcome measure, eight variables predicted LBP in this sample with a 75% correct prediction rate. Predictor variables included age, thoracic acceleration during the trunk velocity test, median frequency intercept of electromyography of the right L3 erector spinae, quadriceps strength, quadriceps endurance, self-assessment of fitness, having a confidante, and number of medications currently taken. Conclusion. Results confirmed the multifactorial nature of low back pain and suggest that personal fitness is an important defense against low back pain, even in manual handling lifting tasks.
Brazilian healthy eating index revised (BHEI-R) of women before and during adjuvant treatment for breast cancer.

INTRODUCTION Different therapeutic modalities for cancer trigger side effects that affect the selection of food by changing dietary patterns. AIMS To evaluate changes in the diet quality of women in adjuvant treatment for breast cancer. METHODS Sociodemographic, clinical and anthropometric data of 78 women were collected. The Brazilian Healthy Eating Index Revised and its components were obtained from food frequency questionnaire applied before and after the treatment. At baseline, participants were classified according to tertiles of diet quality. RESULTS AND DISCUSSION The score of the Brazilian Healthy Eating Index Revised (BHEI-R) in the lowest tertile was 48.4 to 75.2 points, the second tertile was 75.7 to 81.8 points, and the upper tertile was 82.0 to 95.7 points. During treatment, of the women classified in the first tertile, 62% improved their diet score quality passing to the upper tertiles. Women classified in the second tertile, did not significantly alter the diet quality during the treatment, although 46% went to the third tertile. Patients classified in the third tertile significantly reduced the average score of the Index by 7.3 points during the treatment. Among these women, 38% and 20% decreased their score for the second and first tertiles respectively, where the reduction in the diet quality was due to reducing the score of components Total fruits, Total vegetables, Dark Green and orange vegetables and Legumes, Total grains and Solid fats, Alcohol and Added sugar. CONCLUSION Dietary changes, which were observed after breast cancer diagnosis, significantly altered the quality of diet among the women participating in the study. Future nutrition interventions are important to aid in food choices during the treatment.