Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychophysiological Response Patterns of High and Low Alexithymics Under Mental and Emotional Load Conditions

Abstract Compared to normals or low alexithymics, high alexithymic subjects show a modified psychophysiological reactivity under experimental stress. This study aims to differentiate these effects under different load conditions (mental vs. emotional load, 5min each). High (N = 33) and low (N = 33) alexithymic subjects were identified by the German version of the Toronto-Alexithymia-Scale (TAS-20). Subjects were exposed to two tasks of the continuous performance test as a mental load condition and two unpleasant movie sequences as an emotional load condition. Heart rate and electrodermal activity (nonspecific skin conductance reactions) were continuously recorded during stimuli presentation. High alexithymic subjects showed a decreased number of nonspecific skin conductance reactions under all load conditions compared to low alexithymics. Initial heart rate acceleration of high alexithymic subjects under mental load was stronger, whereas under emotional load high alexithymic subjects showed a stronger ini.
Spatial Dynamics of Indoor Radio Wideband Channels

The multipath components of superwideband (2–17.2 GHz) nonline-of-sight channel responses measured inside several buildings are stable along sections that are 27 cm long on average with a standard deviation of 16 cm. The stability regions of multipath components have an approximately log-normal histogram. An analysis of measured channels that explicitly includes finite spatial areas of visibility of the multipath components is superior to the classic analysis that attributes spatial dynamics to interference of the multipath. The spatial stability of measured responses, that is, the size of the typical area of visibility of each multipath component, decreases as the carrier frequency increases but does not depend on bandwidth. The results offer insight into the nature of the diffuse part of the radio channel.
‘Nature’, Place and the Recognition of Indigenous Polities

Abstract In the postcolonial context of Australia there has been a belated legal recognition of sui generis Indigenous rights and interests over much of the continent. However, the pervasive environmental discourse guiding resource management practices remains firmly based on ‘commonsense’ settler understandings of ‘nature’ as an external domain to be managed and/or preserved. In order to understand how this could be otherwise, this paper examines ideas about political landscape formation and the implications of the changing role of the nation-state and civil society in relation to the recognition of Indigenous political subjectivities. Taking the situation faced by Indigenous peoples in two settler societies as our vantage point, I argue here that we need to move away from assimilative environmental governance arrangements and politicise the concept of ‘nature’. This will open up spaces for the recognition and active participation of Indigenous polities in the realm of natural resource management. The paper concludes by contrasting the situation faced by Indigenous landowners in Australia's Kakadu National Park with the overtly political negotiations occurring in two northern regions of Canada. In the latter, in a process similar to what Tully calls ‘daily subconstitutional politics’, it is through the recognition of Indigenous polities in environmental governance issues that Indigenous peoples are starting to refashion their stake in the governing ideas and institutions of the broader regional, provincial and national polity.
Semi-numeric simulations of helium reionization and the fluctuating radiation background

Recent He II Lyman-alpha forest observations from 2.0 2.7. These results point to a fluctuating He-ionizing background, which may be due to the end of helium reionization of this era. We present a fast, semi-numeric procedure to approximate detailed cosmological simulations. We compute the distribution of dark matter halos, ionization state of helium, and density field at z = 3 in broad agreement with recent simulations. Given our speed and flexibility, we investigate a range of ionizing source and active quasar prescriptions. Spanning a large area of parameter space, we find order-of-magnitude fluctuations in the He II ionization rate in the post-reionization regime. During reionization, the fluctuations are even stronger and develop a bimodal distribution, in contrast to semi-analytic models and the hydrogen equivalent. These distributions indicate a low-level ionizing background even at significant He II fractions.
Hypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians

Higher brain dopamine content depending on lower activity of Catechol-O-Methyltransferase (COMT) in subjects with high hypnotizability scores (highs) has been considered responsible for their attentional characteristics. However, the results of the previous genetic studies on association between hypnotizability and the COMT single nucleotide polymorphism (SNP) rs4680 (Val158Met) were inconsistent. Here, we used a selective genotyping approach to re-evaluate the association between hypnotizability and COMT in the context of a two-SNP haplotype analysis, considering not only the Val158Met polymorphism, but also the closely located rs4818 SNP. An Italian sample of 53 highs, 49 low hypnotizable subjects (lows), and 57 controls, were genotyped for a segment of 805 bp of the COMT gene, including Val158Met and the closely located rs4818 SNP. Our selective genotyping approach had 97.1% power to detect the previously reported strongest association at the significance level of 5%. We found no evidence of association at the SNP, haplotype, and diplotype levels. Thus, our results challenge the dopamine-based theory of hypnosis and indirectly support recent neuropsychological and neurophysiological findings reporting the lack of any association between hypnotizability and focused attention abilities.
A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children

We present a multilevel approach to developing potential explanations of cognitive impairments and psychopathologies common to individuals with chromosome 22q11.2 deletion syndrome. Results presented support our hypothesis of posterior parietal dysfunction as a central determinant of characteristic visuospatial and numerical cognitive impairments. Converging data suggest that brain development anomalies, primarily tissue reductions in the posterior brain and changes to the corpus callosum, may affect parietal connectivity. Further findings indicate that dysfunction in “frontal” attention systems may explain some executive cognition impairments observed in affected children, and that there may be links between these domains of cognitive function and some of the serious psychiatric conditions, such as attention-deficit/hyperactivity disorder, autism, and schizophrenia, that have elevated incidence rates in the syndrome. Linking the neural structure and the cognitive processing levels in this way enabled us to develop an elaborate structure/function mapping hypothesis for the impairments that are observed. We show also, that in the case of the catechol-O-methyltransferase gene, a fairly direct relationship between gene expression, cognitive function, and psychopathology exists in the affected population. Beyond that, we introduce the idea that variation in other genes may further explain the phenotypic variation in cognitive function and possibly the anomalies in brain development.We thank the children and families that participated in our studies and the staff of the 22q and You Center at the Children's Hospital of Philadelphia. This work was supported by grants from the NIH (R01HD42974 and R01HD46159) and the Philadelphia Foundation to T.J.S. , Grant PO1DC02027 to B.S.E. , and Grant M01-RR00240 to the Children's Hospital of Philadelphia.
Information Transfer Through Stochastic Transmission of a Linear Combination of Rates

In this work, the Shannon information transfer rate due to the transmission of a linear combination of the firing rates of a number of afferent neurons is examined. The transmission of this linear combination (transfer statistic) takes place through a stochastic firing process, while a rate code is assumed. Constraints are imposed on the transmission process by the requirement that the coefficient of variation for the transfer statistic is small and by the relative variance of the individual terms in the calculation of the statistic. In the regime of no noise or signal correlations among the input neurons, simulations suggest that information transfer for fixed overall input is favored when there are few high-firing neurons, as opposed to more lower-firing neurons. Signal correlations among low-firing neurons can result in aggregates of high firing rates, improving in this way information transfer and calculational robustness. Under reasonable rate code assumptions, information transfer rates obtained are of the order 3 to 10 bit/sec.
Mouse Mammary Tumor Virus Encodes a Self-Regulatory RNA Export Protein and Is a Complex Retrovirus

ABSTRACT Mouse mammary tumor virus (MMTV) has been classified as a simple retrovirus with two accessory genes, dut and sag. Cloned MMTV proviruses carrying a trimethoprim (trim) cassette in the envelope gene were defective for Gag protein production and the nuclear export of unspliced gag-pol RNA. Complementation experiments indicated that a trans-acting product was responsible for the Gag defect of such mutants. Analysis of MMTV-infected cells revealed the presence of a novel, doubly spliced RNA that encodes a putative product of 301 amino acids. Overexpression of cDNA from this RNA increased Gag levels from env mutant proviruses or reporter gene expression from unspliced mRNAs and allowed detection of a 33-kDa protein product, which has been named regulator of export of MMTV mRNA, or Rem. The Rem N terminus has motifs similar to the Rev-like export proteins of complex retroviruses, and mutation of the nuclear localization signal (NLS) abolished RNA export and detection within the nucleus. The Rem C terminus has few identifiable features, but removal of this domain increased Rem-mediated export, suggesting an autoregulatory function. A reporter vector developed from the 3′ end of the MMTV provirus was Rem responsive and required both the presence of the MMTV env-U3 junction and a functional Crm1 pathway. The identification of a third accessory protein from a doubly spliced transcript suggests that MMTV is the first murine complex retrovirus to be documented. Manipulation of the MMTV genome may provide mouse models for human retroviral diseases, such as AIDS.
Structural crack detection using deep learning–based fully convolutional networks

Cracks are a potential threat to the safety and endurance of civil infrastructures, and therefore, careful and regular structural crack inspection is needed during their long-term service periods. Many image-processing approaches have been developed for structural crack detection. However, like traditional edge detection algorithms, these methods are easily disturbed by the environmental effect. Convolutional neural networks are newly developed methods and have excellent performances in the image-classification tasks. This study proposes a fully convolutional network called Ci-Net for structural crack identification. Pixel-level labeled image training data are obtained from the online data set. Four indices are adopted to evaluate the performance of the trained Ci-Net. Crack images from an indoor concrete beam test are adopted for validation of its structural crack recognition capacity. The recognition results are also compared with those obtained by the edge detection methods. It indicates that Ci-Net exhibits a better performance over the edge detection methods in structural damage detection.
Perseverance Measures and Attainment in First Year Computing Science Students

We investigate the link between concepts of perseverance such as conscientiousness and grit, and the academic attainment of first year computing students. We review the role that perseverance plays in learning models, as well as describing the trait of conscientiousness in the Five Factor Model of personality. We outline research that links this trait with academic success, before focussing on more recent, narrower conceptualisations of perseverance such as academic tenacity and grit. We describe one of the questionnaire tools that have been used to assess the construct of grit. We give details of an investigation that looked for correlations between student responses to Duckworth's Grit Survey, the Big Five Inventory (BFI) Personality Survey and summative attainment scores in a first year programming course. The results suggest a weak but significant correlation between conscientiousness, grit and programming achievement. We discuss these results as well as the limitations of the method used. Finally, we make some observations about the importance of these concepts in Computer Science education and outline further work in this area.
The Use of Group and Groupcentric Individual Goals for Culturally Heterogeneous and Homogeneous Task Groups

Three hundred and fifteen workers from three multinational corporations participated in this study. The results demonstrated that group goals were able to increase task performance for homogeneous collectivist groups as well as for groups composed of both individualists and collectivists. The ability of a group goal to facilitate team performance for both heterogeneous and homogeneous work groups lends support to the intercultural properties of group goals for interdependent task groups.
From Brain to Bile

The brain is the almost exclusive site of formation of 24S-hydroxycholesterol in man, and there is a continuous flux of this oxysterol across the blood-brain barrier into the circulation. The hepatic metabolism of 24S-hydroxycholesterol was studied here by three different approaches: incubation of tritium-labeled 24S-hydroxycholesterol with human primary hepatocytes, administration of tritium-labeled 24S-hydroxycholesterol to a human volunteer, and quantitation of free and conjugated 24S-hydroxycholesterol and its neutral metabolites in ileocecal fluid from patients with ileal fistulae. 24S-Hydroxycholesterol as well as 24R-hydroxycholesterol were converted into bile acids by human hepatocytes at a rate of about 40% of that of the normal intermediate in bile acid synthesis, 7α-hydroxycholesterol. There was also a conversion of 24S-hydroxycholesterol into conjugate(s) of 5-cholestene-3β,24S,27-triol at a rate similar to the that of conversion into bile acids. When administered to a human volunteer, labeled 24S-hydroxycholesterol was converted into bile acids at about half the rate of simultaneously administered labeled 7α-hydroxycholesterol. Free, sulfated, and glucuronidated 24S-hydroxycholesterol and 5-cholestene-3β,24,27-triol were identified in ileocecal fluid. The excretion of these steroids was about 3.5 mg/24 h, amounting to more than 50% of the total estimated flux of 24S-hydroxycholesterol from the brain. It is concluded that 24S-hydroxycholesterol is a less efficient precursor to bile acids and that about half of it is conjugated and eliminated in bile as such or as a conjugate of a 27-hydroxylated metabolite. The less efficient metabolism of 24S-hydroxycholesterol may explain the surprisingly high levels of this oxysterol in the circulation and is of interest in relation to the suggested role of 24S-hydroxycholesterol as a regulator of cholesterol homeostasis.
The Ties that Bind

This article proposes a typology of migration based on duration of annual residence in planned retirement communities. The categories of the typology-seasonal in-migrant, seasonal out-migrant, seasonal traveler, and year-round resident-are used to classify a sample of households in a southwestern retirement community. The findings suggest that out-of-state children and ties to small towns are inhibiting influences on permanent relocation after retirement. Facilitating factors associated with seasonal migration include: a spouse in the household, higher socioeconomic status, and the absence of health restrictions on activities.
Rod Function in Diabetic Patients without and with Early Diabetic Retinopathy

Purpose To compare rod function among diabetic patients without and with mild nonproliferative diabetic retinopathy (DR) and healthy controls by means of scotopic microperimetry and dark-adapted electroretinography. Methods Sixty-one diabetic patients and 30 age-matched controls (control group) underwent complete ophthalmic examination, scotopic microperimetry, and dark-adapted 0.01 electroretinography (DA-ERG). Results In 32 eyes, DR was absent (no-DR group); in 29 eyes, only microaneurysms were observed (DR group). No statistically significant differences in fixation stability, fixation location, or scotopic sensitivity among the 3 groups were observed. Implicit time and amplitude of the DA-ERG b-wave of no-DR and DR groups were not different from controls. Scotopic microperimetry showed a dense scotoma centered onto the fovea in all subjects, consistent with the rod-free zone. Greater scotopic sensitivity was found in a ring located 8° from the fovea (9.33 ± 1.33 dB). Conclusions Diabetic patients without DR and with mild nonproliferative DR did not show alterations in rod-based function, as examined by microperimetry and confirmed by DA-ERG. Scotopic microperimetry measures rod-based function and offers additional information in the evaluation of the aspects of involvement of retinal cells in diabetes.
Ankyrin-Dependent and -Independent Mechanisms Orchestrate Axonal Compartmentalization of L1 Family Members Neurofascin and L1/Neuron–Glia Cell Adhesion Molecule

Axonal initial segments (IS) and nodes of Ranvier are functionally important membrane subdomains in which the clustering of electrogenic channels enables action potential initiation and propagation. In addition, the initial segment contributes to neuronal polarity by serving as a diffusion barrier. To study the mechanisms of axonal compartmentalization, we focused on two L1 family of cell adhesion molecules (L1-CAMs) [L1/neuron–glia cell adhesion molecule (L1/NgCAM) and neurofascin (NF)] and two neuronal ankyrins (ankB and ankG). NF and ankG accumulate specifically at the initial segment, whereas L1/NgCAM and ankB are expressed along the entire lengths of axons. We find that L1/NgCAM and NF show distinct modes of steady-state accumulation during axon outgrowth in cultured hippocampal neurons. Despite their different steady-state localizations, both L1/NgCAM and NF show slow diffusion and low detergent extractability specifically in the initial segment but fast diffusion and high detergent extractability in the distal axon. We propose that L1-CAMs do not strongly bind ankB in the distal axon because of spatial regulation of ankyrin affinity by phosphorylation. NF, conversely, is initially enriched in an ankyrin-independent manner in the axon generally and accumulates progressively in the initial segment attributable to preferential binding to ankG. Our results suggest that NF and L1/NgCAM accumulate in the axon by an ankyrin-independent pathway, but retention at the IS requires ankyrin binding.
Hepcidin Destabilizes Atherosclerotic Plaque Via Overactivating Macrophages After Erythrophagocytosis

Objective—To explore a direct and causal relationship between vascular hepcidin and atherosclerotic plaque stability. Methods and Results—Accelerated atherosclerotic lesions were established by perivascular collar placement in apolipoprotein E–deficient (ApoE−/−) mice. Adenoviral overexpression of hepcidin in the carotid artery during plaque formation enhanced intraplaque macrophage infiltration and suppressed the contents of collagen and vascular smooth muscle cells, whereas hepcidin shRNA treatment exerts opposite effects. The overexpression or knockdown of hepcidin did not affect plaque lipid deposition but increased or decreased oxidized low-density lipoprotein (ox-LDL) levels within intraplaque macrophages. In cultured macrophages, ox-LDL not only increased reactive oxygen species formation, inflammatory cytokine production, and apoptosis but also upregulated hepcidin expression. However, hepcidin did not exaggerate the ox-LDL–induced activation of macrophages until an onset of erythrophagocytosis. Whereas hepcidin was critical for the upregulation of L-ferritin and H-ferritin in both ox-LDL–treated erythrophagocytosed macrophages and atherosclerotic plaques, the adding of iron chelators suppressed the intracellular lipid accumulation, reactive oxygen species formation, inflammatory cytokine expression, and apoptosis in erythrophagocytosed macrophages. Conclusion—Hepcidin promotes plaque destabilization partly by exaggerating inflammatory cytokine release, intracellular lipid accumulation, oxidative stress, and apoptosis in the macrophages with iron retention.
Testing reciprocal relationships between job characteristics and psychological well-being: A cross-lagged structural equation model

This article describes a two-wave panel study which was carried out to examine reciprocal relationships between job characteristics and work-related psychological well-being. Hypotheses were tested in a sample of 261 health care professionals using structural equation modelling (LISREL 8). Controlling for gender, age, and negative affectivity, the results primarily supported the hypothesis that Time 1 job characteristics influence Time 2 psychological well-being. More specifically, Time 2 job satisfaction was determined by Time 1 job demands and workplace social support, respectively. Furthermore, there was also some preliminary but weak evidence for reversed cross-lagged effects since Time 1 emotional exhaustion seemed to be the causal dominant factor with respect to Time 2 (perceived) job demands. In conclusion, this study builds on earlier cross-sectional and longitudinal findings by eliminating confounding factors and diminishing methodological deficiencies. Empirical support for the influence of job characteristics on psychological well-being affirms what several theoretical models have postulated to be the causal ordering among job characteristics and work-related psychological well-being.
Multidimensional Self-Concepts

Marsh, Richards, and Barnes (1986) examined systematic change and stability in multiple dimensions of self-concept and the effects of participation in a 26-day residential program called Outward Bound. Multidimensional self-concepts measured with the Self Description Questionnaire (SDQ) III increased as a consequence of the intervention and the increases were significantly larger for those facets judged a priori to be more relevant to program goals. For purposes f the present investigation participants from the previous study were asked to complete the SDQ III again, 18 months after completion of the program; and there was little systematic change in the multidimensional self-concepts during the long-term follow-up interval. Coupled with the results of the earlier study and further examination of the psychometric properties of the SDQ III, these findings further support the Outward Bound program as an effective intervention for enhancing self-concept and the construct validity of responses to the SDQ III. The longitudinal study of successful interventions designed to enhance self-concept are rare, and so the findings are important in that they demonstrate that self-concept can be changed through effective intervention and that these effects can be maintained.