Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypocotyl Transcriptome Reveals Auxin Regulation of Growth-Promoting Genes through GA-Dependent and -Independent Pathways

Many processes critical to plant growth and development are regulated by the hormone auxin. Auxin responses are initiated through activation of a transcriptional response mediated by the TIR1/AFB family of F-box protein auxin receptors as well as the AUX/IAA and ARF families of transcriptional regulators. However, there is little information on how auxin regulates a specific cellular response. To begin to address this question, we have focused on auxin regulation of cell expansion in the Arabidopsis hypocotyl. We show that auxin-mediated hypocotyl elongation is dependent upon the TIR1/AFB family of auxin receptors and degradation of AUX/IAA repressors. We also use microarray studies of elongating hypocotyls to show that a number of growth-associated processes are activated by auxin including gibberellin biosynthesis, cell wall reorganization and biogenesis, and others. Our studies indicate that GA biosynthesis is required for normal response to auxin in the hypocotyl but that the overall transcriptional auxin output consists of PIF-dependent and -independent genes. We propose that auxin acts independently from and interdependently with PIF and GA pathways to regulate expression of growth-associated genes in cell expansion.
Adaptive sorted neighborhood methods for efficient record linkage

Traditionally, record linkage algorithms have played an important role in maintaining digital libraries - i.e., identifying matching citations or authors for consolidation in updating or integrating digital libraries. As such, a variety of record linkage algorithms have been developed and deployed successfully. Often, however, existing solutions have a set of parameters whose values are set by human experts off-lineand are fixed during the execution. Since finding the ideal values of such parameters is not straightforward, or no such single ideal value even exists, the applicability of existing solutions to new scenarios or domains is greatly hampered. To remedy this problem, we argue that one can achieve significant improvement by adaptively and dynamically changing such parameters of record linkage algorithms. To validate our hypothesis, we take a classical record linkage algorithm, the sorted neighborhood method (SNM), and demonstrate how we can achieve improved accuracy and performance by adaptively changing its fixed sliding window size. Our claim is analytically and empirically validated using both real and synthetic data sets of digital libraries and other domains.
The Free and Cued Selective Reminding Test: evidence of psychometric adequacy

These analyses examine the psychometric properties of the Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR). FCSRT-IR is a measure of memory under conditions that control attention and cognitive processing in order to obtain an assessment of memory unconfounded by normal age-related changes in cognition. FCSRT-IR performance has been associated with preclinical and early dementia in several longitudinal epidemiological studies. Factor and item response theory analyses were applied to FCSRT-IR data from patients at a geriatric primary care center who had independently established clinical diagnoses. The results provide supporting evidence for the psychometric adequacy of the FCSR-IR in terms of reliability, essential (sufficient) unidimensionality, information across the continuum of memory disability/ability, and classification accuracy. The psychometric adequacy of the FCSRT - IR adds further validity to its use as a case finding strategy for dementia.
EBW Simulations in an Experimental Context

In the past several years we have been developing simulation techniques for electron Bernstein wave (EBW) physics in toroidal fusion devices. EBW simulations are rather difficult for several reasons. EBWs are electrostatic waves, whose propagation is strongly affected by the plasma parameters. EBWs cannot propagate in a vacuum and must be coupled to X- and/or O-modes. The conversion efficiency must be in general computed numerically by a full-wave solver. Details of our code AMR are described. This includes electrostatic ray-tracing, EBW root finder and 1D full-wave adaptive finite elements solver of the EBW-X-O mode conversion. The plasma configuration is handled by independent modules and typically obtained from experimental results. A Python driver script handles user configuration files and is able to parallelize the simulation. We describe applications of AMR to support various experiments. It is used to interpret EBW emission from the spherical tokamaks MAST and NSTX, to confirm the resonant EBW heating on the WEGA stellarator, to model its new 28 GHz system and to predict the applicability of the designated EBW emission radiometer for COMPASS. Keywords: plasma, fusion, tokamak, stellarator, electron Bernstein wave, simulation, full-wave, ray-tracing.
Efficiency Optimization for Wireless Dynamic Charging System With Overlapped DD Coil Arrays

Wireless dynamic charging is one of the most promising power supply methods for electric vehicles (EVs), which can reduce battery volume and extend EVs’ range. Stable output power and high system efficiency are two of the most important features for practical applications of wireless dynamic charging. For the low-speed application scenarios of dynamic charging, an efficiency optimization method is proposed to improve the system efficiency while regulating the output voltage. Two overlapped DD coils are employed to generate an enhanced magnetic field without dead points. An optimized current control method is proposed to adjust the direction and the ratio of the two transmitter currents as the receiver moves along the track, dynamically. By applying this method, the efficiency of dynamic charging system can be optimized while the output power can be regulated to the desired value at the same time. A 600 W prototype is established to validate the performance of the proposed method. The experimental results show that the system efficiency for dynamic charging reaches 88.3%–90.4% with the proposed method. The maximum efficiency improvement of proposed algorithm is 2.3% compared to that with the same energized currents for both DD coils.
Severity Stages in Essential Tremor: A Long-Term Retrospective Study Using the Glass Scale

Background Few prospective studies have attempted to estimate the rate of decline of essential tremor (ET) and these were over a relatively short time period (less than 10 years). We performed a long-term study of severity stages in ET using the Glass Scale scoring system. Methods Fifty consecutive patients with severe ET were included. We retrospectively obtained Glass Scale scores throughout the patient's life. Common milestone events were used to help recall changes in tremor severity. Results According to the Glass Scale, the age distributions were as follows: score I, 40±17 years, score II, 55±12 years, score III, 64±9 years, and score IV, 69±7 years. A significant negative correlation between age at first symptom and rate of progression was found (r = −0.669, p<0.001). The rate of progression was significantly different (p<0.001) when the first symptom appeared at a younger age (under 40 years of age) compared with older age (40 years or older). Discussion Our results support the progressive nature of ET. Age at onset was a prognostic factor. The Glass Scale may be a useful tool to determine severity stages during the course of ET in a manner similar to the Hoehn and Yahr Scale for Parkinson's disease.
Prediction of spontaneous preterm birth using fetal fibronectin in women with a low-lying placenta

Abstract Objective: To determine the effect of a low-lying placenta on the concentration of quantitative fetal fibronectin (qfFN) in the cervicovaginal fluid (CVF), and predictive accuracy for spontaneous preterm birth in asymptomatic high-risk women (18 + 0–24 + 0 weeks gestation). Methods: Median concentrations of qfFN were compared in women who had a low-lying placenta, covering the cervical os (n = 61) to matched controls (n= 61) without a low-lying placenta. Proportions of women with raised qfFN concentrations (>10 ng/ml), and false positive and negative rates (FPR and FNR) for spontaneous preterm delivery were also compared. Results: The median concentration of qfFN in women with low-lying placenta was 5.0 ng/mL, compared with 6.0 ng/mL in controls. Proportion of women with raised levels (>10 ng/mL), positive levels (>50 ng/mL) and very high levels (>200 ng/mL) were similar in both groups (62.3% versus 59.0%, 16.3% versus 22.0% and 6.5% versus 4.9%, p > 0.05 for all thresholds). The FPR and FNR rate for delivery before 34 and 37 weeks were also comparable (FPR 90.0% versus 85.7% and 80.0% versus 78.6%; FNR 5.8% versus 4.3% and 9.8% versus 8.5%). Conclusions: CVF qfFN concentrations in asymptomatic high-risk women are not affected by the presence of a low-lying placenta.
Glioblastomas with oligodendroglial component have the same clinical phenotype as classical glioblastomas

Abstract Introduction. Glioblastomas are the commonest primary brain tumour and are considered one of the most heterogeneous tumour types. The introduction of a glioblastoma with oligodendroglial component (GBM + O) in the latest WHO Classification of Tumours of the Central Nervous System 1 was to help with this. There has been conflicting evidence as to whether this tumour conferred a better prognosis than classical glioblastoma (GBM). The aim of this study was to study the clinical phenotype of these GBM + O tumours and compare it to the classical GBM. Materials and methods. All patients with histological evidence of a glioblastoma between 1st January 2007 and 31st January 2011 were identified from the Neuropathology Database. Clinical and radiological details were obtained for all patients. The overall survival of patients who were treated with chemoradiotherapy was obtained and the GBM + O cohort compared to the classical GBM cohort. Results. Three hundred and ninety-six patients with newly diagnosed glioblastomas were identified: 294 (74.2%) had classical GBM and 102 (25.6%) had GBM + O. The two cohorts presented at a similar age (61.1 years GBM + O vs. 63.2 years GBM; P = 0.09) and were matched for sex and side of the tumour. GBM + O were more likely to be located in the frontal lobes (38.2% for GBM + O vs. 27.2% for GBM: P = 0.04). In the group that was treated with chemoradiotherapy the overall survival was similar (median survival GBM + O 361 days vs. 379 days GBM; Log Rank 0.61, P = 0.43). Conclusion. The presence of an oligodendroglial component does not confer any improvement in survival and has a similar clinical phenotype to classical GBMs.
Type III Collagen, a Fibril Network Modifier in Articular Cartilage*

The collagen framework of hyaline cartilages, including articular cartilage, consists largely of type II collagen that matures from a cross-linked heteropolymeric fibril template of types II, IX, and XI collagens. In the articular cartilages of adult joints, type III collagen makes an appearance in varying amounts superimposed on the original collagen fibril network. In a study to understand better the structural role of type III collagen in cartilage, we find that type III collagen molecules with unprocessed N-propeptides are present in the extracellular matrix of adult human and bovine articular cartilages as covalently cross-linked polymers extensively cross-linked to type II collagen. Cross-link analyses revealed that telopeptides from both N and C termini of type III collagen were linked in the tissue to helical cross-linking sites in type II collagen. Reciprocally, telopeptides from type II collagen were recovered cross-linked to helical sites in type III collagen. Cross-linked peptides were also identified in which a trifunctional pyridinoline linked both an α1(II) and an α1(III) telopeptide to the α1(III) helix. This can only have arisen from a cross-link between three different collagen molecules, types II and III in register staggered by 4D from another type III molecule. Type III collagen is known to be prominent at sites of healing and repair in skin and other tissues. The present findings emphasize the role of type III collagen, which is synthesized in mature articular cartilage, as a covalent modifier that may add cohesion to a weakened, existing collagen type II fibril network as part of a chondrocyte healing response to matrix damage.
Blurring the boundaries: a collaborative approach to language and learning support for social work students

Victoria University in melbourne, australia attracts students with diverse histories and cultural backgrounds. Academic staff of the Social Work Unit have a long history of working with staff from learning Support Services to assist students to develop their academic skills. In 2011, social work and learning support staff have worked together to develop a new collaborative approach to learning support, characterised by an ‘outreach’ approach of bringing highly contextualised learning support to the students in their social work course, rather than trying to encourage the students to attend separate learning support services. This new approach blurs the boundaries between the disciplinespecific teaching and the learning support. It was stimulated by the University’s pilot of a language literacy and numeracy (lln) strategy. Underpinning this approach is the idea that all students are being apprenticed into a new discursive space. Situated and explicit lln support is the focus, and staff approach lln in developmental rather than deficit terms. This paper describes the outreach approach and explores what made this collaborative approach possible. Some of the factors identified include shared commitment to a student-centred approach that works with strengths rather than deficits, and the compatibility of the critical social work approach of the social work staff with the critical literacy approach of the learning support staff.
Educating the Country Out of the Child and Educating the Child Out of the Country: An Excursion in Spectrology

A focus on rurality has been largely absent from much contemporary educational policy discussion. At best, rural education is a peripheral concern just as rural areas are increasingly considered marginal to the development of a globalized, networked, fast capitalism. In Canada rural, coastal, northern, and single-industry communities that were built around primary resource extraction are constructed as social and educational problem spaces partly because their residents are often attached to these places long after they have served their economic purpose as natural resource deposits for the interests of capital. In fact rurality and rusticity are typically seen as one face of the kind of localized social condition that formal education is designed to normalize and transform by fostering outmigration and a general orientation to urban life and to mobility. In this analysis I use Derrida’s idea of spectrology to examine some images of rurality as persistent, place-attached ghosts haunting the educational project of modernity.
The Role of Heterogeneity in the Persistence and Prevalence of Sin Nombre Virus in Deer Mice

Many diseases persist at a relatively low prevalence, seemingly close to extinction. For a chronic disease in a homogeneous population, reducing the transmission rate by a fraction proportional to the prevalence would be sufficient to eradicate the disease. This study examines how higher prevalence of the Sin Nombre virus in male deer mice (Peromyscus maniculatus) might contribute to disease persistence. Analyzing data from over 2,000 individual mice captured in 19 sites over 4 years, we found prevalences of 18.5% in males and 8.8% in females. By examining recaptures, we determined that males are more likely to contract the infection because of higher susceptibility or higher encounter rates. Comparing across 86 sampling periods, we found a higher proportion of males when population densities were low. A capture‐recapture analysis indicates that males live longer than females. A mathematical model based on the measured parameters and population size trajectories suggests that the combined heterogeneity in encounters, susceptibility, and mortality may buffer the disease from extinction by concentrating disease in the subgroup most likely to transmit the disease. This buffering effect is not significantly stronger in a fluctuating population, indicating that these forms of heterogeneity might not be the key for disease persistence through host population bottlenecks.
The impact of using multimedia in English high school classes on students' language achievement and goal orientation

The study aimed to examine the effectiveness of using multimedia elements in teaching English for the eighth graders in public schools. For answering the questions of the study, the researchers adopted the experimental approach. The sample of the study consisted of (58) female students from Navid girl high School in an urban setting in Mashhad (a city in Northeast of Iran). The results of a pretest indicated that the participants of the two groups were homogenous with regard to their proficiency level. The researchers divided the sample of the study into two groups, experimental and control group. In addition to official book (prospect 2), the experimental group was exposed to multimedia elements as animations, cartoons, and Power Point Presentation (P.P.P.). But in control group, prospect 2 was taught through traditional chalk and board instruction in the first term of the academic school year (2014−2015). The results of the post-test indicated that using multimedia elements has a positive and significant influence on learners' achievement as well as on their achievement goal orientation (mastery, performance, and avoidance). In particular, students in experimental group tended to adopt a mastery-goal orientation as the result of technology-based instruction. In the light of these results, the study recommended the necessity of implementing multimedia in teaching English.
Competing constructions of children's participation in social care : analysing text and talk

This thesis is about how the concept of participation constructs children as subjects within social welfare formations. It is the result of a qualitative and interpretive research project using narrative and discourse analysis as key methodologies. The research is theoretically framed within the social constructionist, post-structuralist, feminist and psychoanalytic perspectives. By using these the thesis explores the competing constructions of children’s participation within social/legal policy texts and the discourses of social care. The focus is on children within contemporary UK welfare contexts who are either identified as being ‘at risk’ of significant harm or who are Looked After by the local authority. I examine the way that children’s participation is framed by the Children Act, 1989 (England and Wales), the United Nations Convention on the Rights of the Child and Quality Protects. I analyse the policy and interview texts to show how the discourses of protectionism, developmentalism, rights and managerialism compete unevenly across them. I argue that there is a new configuration of welfare developing around children’s services where managerialism is dominant and children’s rights are collapsed into the customer discourse. Children’s voices are either absent or mediated by adult/professionals in most of the formal policy texts. This thesis explores the affective and emotional aspects of performing participation with children. My data shows how individual professionals as well as the institutions of welfare experience anxiety and strain about how to enable and manage the participation of children. I show how professionals and welfare institutions develop various coping strategies, whose effects include the avoidance of the difficulties of listening to children.
Valence Asymmetries in the Human Amygdala: Task Relevance Modulates Amygdala Responses to Positive More than Negative Affective Cues

Organisms must constantly balance appetitive needs with vigilance for potential threats. Recent research suggests that the amygdala may play an important role in both of these goals. Although the amygdala plays a role in processing motivationally relevant stimuli that are positive or negative, negative information often appears to carry greater weight. From a functional perspective, this may reflect the fact that threatening stimuli generally require action, whereas appetitive stimuli can often be safely ignored. In this study, we examine whether amygdala activation to positive stimuli may be more sensitive to task goals than negative stimuli, which are often related to self-preservation concerns. During fMRI, participants were presented with two images that varied on valence and extremity and were instructed to focus on one of the images. Results indicated that negative stimuli elicited greater amygdala activity regardless of task relevance. In contrast, positive stimuli only led to a relative increase in amygdala activity when they were task relevant. This suggests that the amygdala may be more responsive to negative stimuli regardless of their relevance to immediate goals, whereas positive stimuli may only elicit amygdala activity when they are relevant to the perceivers' goals. This pattern of valence asymmetry in the human amygdala may help balance approach-related goal pursuit with chronic self-preservation goals.
FASILITAS, SERVICESCAPE, DAN KUALITAS PELAYANAN, PENGARUHNYA TERHADAP KEPUASAN KONSUMEN MCDONALD’S MANADO

Mc Donald’s adalah salah satu restoran cepat saji yang ada di Manado dimana manajemen berupaya memperhatikan fasilitas, servicescape, dan kualitas layanan untuk meningkatkan kepuasan konsumen. Dengan pendapatan yang besar, sangat memungkinkan Mc Donald’s untuk mengembangkan fasilitas, servicescape, dan kualitas pelayanan dengan menambah area bermain anak dan wi-fi bagi kepuasan konsumennya. Penelitian ini bertujuan untuk menguji pengaruh fasilitas, servicescape dan kualitas pelayanan terhadap kepuasan konsumen. Populasi penelitian ini adalah para konsumen yang sedang makan di Mc Donald’s Manado dan sampel yang digunakan sebanyak 100 orang dengan menggunakan metode accidental sampling . Teknik analisis yang digunakan adalah uji asosiatif melalui pembuktian hipotesis. Hasil penelitian menunjukan bahwa secara simultan dan parsial fasilitas, servicescape, dan kualitas pelayanan berpengaruh positif dan signifikan terhadap kepuasan konsumen. Pihak manajemen Mc Donald’s Manado sebaiknya meningkatkan kualitas pelayanan yang diberikan kepada konsumen, karena sesuai dengan hasil penelitian variabel ini sangat lemah pengaruhnya. Kata kunci: fasilitas, servicescape, kualitas pelayanan, kepuasan konsumen.