Miracle-dz/UniFAR-FTUs huggingface dataset:
Postcoital Dysphoria: Prevalence and Psychological Correlates

Abstract Introduction While problems related to desire, arousal, and orgasm have been subject to extensive epidemiologic research, women's postcoital reactions and feelings, and postcoital dysphoria (PCD) remains under‐researched. Aim The study examined the association between women's attachment anxiety and avoidance, differentiation of self, and the experience of PCD symptoms. Methods Two hundred and thirty female university students completed an online survey. Main Outcome Measures The Female Sexual Function Index, the Experiences in Close Relationships Scale, the Differentiation of Self Inventory‐Revised, and study specific questions. Results Forty‐six percent of respondents reported experiencing PCD symptoms at least once in their lifetime with 5.1% experiencing PCD symptoms a few times within the past 4 weeks. A small but significant inverse correlation was found between lifetime prevalence of PCD and sexual functioning (r = −0.16). While the regression model accounted for 22% of variance in lifetime prevalence of PCD, attachment and differentiation of self variables did not account for significant variance. Conclusions The findings confirm that PCD is under‐recognized and under‐researched. There appears to be no relationship between PCD and intimacy in close relationships. Further research is necessary to understand the subjective experience of PCD and to inform the development of a reliable measure. Schweitzer RD, O'Brien J, and Burri A. Postcoital dysphoria: Prevalence and psychological correlates. Sex Med 2015;3:229–237.
Adaptation in pheromone-sensitive trichoid sensilla of the hawkmoth Manduca sexta

SUMMARY In extracellular tip recordings from long trichoid sensilla of male Manduca sexta moths, we studied dose–response relationships in response to bombykal stimuli of two different durations in the adapted and the non-adapted state. Bombykal-responsive cells could be distinguished from non-bombykal-sensitive cells in each trichoid sensillum because the bombykal-responsive cell always generated the action potentials of larger initial amplitude. The bombykal cell, which was recorded at a defined location within a distal flagellar annulus, can resolve at least four log10-units of pheromone concentrations but is apparently unable to encode all stimulus durations tested. Parameters of the amplitude-modulated sensillar potential and the frequency-modulated action potential responses were examined in different states of adaptation. Evidence is presented for the existence of several mechanisms of adaptation, which affect distinct steps of the transduction cascade. After adapting pheromone stimuli, the sensillar potential rises to a lower amplitude and declines faster compared with the non-adapted response. In addition, the frequency of the adapted action potential response is reduced. Only the time of rise of the sensillar potential is differentially affected by adapting pheromone stimuli of different duration. The time of rise does not increase after short, but only after long, adapting stimuli. Both short and long adapting stimuli shift the dose–response curves of the sensillar potential amplitude, as well as the initial slope of its rising phase, to higher stimulus concentrations by approximately one log10-unit. The shift in the dose–response curve of the action potential response is larger than for the sensillar potential response, suggesting that an additional adaptation mechanism acts at the level of action potential generation. Furthermore, a faster decline of the sensillar potential after short and long adapting stimuli suggests that the resting potential of the olfactory receptor neuron is stabilized.
STUDIES ON T H E MODE OF ACTION OF DIPHTHERIA TOXIN

I t has been shown in previous communications that, in the presence of the specific cofactor nicotinamide adenine dinucleotide (NAD), diphtheria toxin inhibits the transfer of amino acids from aminoacyl-tRNA to the growing polypeptide chains on the ribosomes in cell-free extracts from mammalian cells (1). Although bacterial cell extracts axe completely insensitive to inhibition (1), toxin and NAD inhibit amino acid incorporation in cell-free extracts from chick embryonic tissues (2) and from yeast (3). Collier (4) has demonstrated that toxin and NAD act specifically to cause inactivation of the labile peptide bondforming enzyme, transferase II (s). Goor and Pappenheimer (6) also concluded that transferase n was the site of toxin action in cell extracts and noted that only the soluble form was inactivated; the ribosome-bound enzyme was not affected. I t was further observed (3) that the inactivation of transferase II in cell-free systems could be prevented or reversed in the presence of a sufficient concentration of nicotinamide. Finally, it has been found that toxin and NAD interact mole for mole to form a relatively dissociable complex (7, 8). Assuming that this toxin-NAD complex interacts further with transferase II to form an enzymatically inactive product, an equation based on the mass law has been derived that accurately predicts the per cent inhibition of amino acid incorporation in cell-free systems at any given NAD and toxin concentration (3). Although the model we have just described adequately explains the action of toxin in cell-free systems, serious difficulties arise when we attempt to use the model to explain the inhibition by toxin of growth of HeLa cells in culture (3). First, the action of toxin on living HeLa cells is not reversible in the presence of
Associations of Fibroblast Growth Factor-23 with Markers of Inflammation, Insulin Resistance and Obesity in Adults

Introduction Elevated fibroblast growth factor-23 (FGF23) is an established marker of cardiovascular disease. The underlying reason(s) for the rise accompanying cardiovascular health decline are unclear. Prior studies have shown that FGF23 concentrations are associated with markers of inflammation and insulin resistance but they have been limited by a focus on persons with chronic kidney disease (CKD) and lack of race and sex diversity. The objective of this study was to examine the associations of FGF23 and markers of inflammation, insulin resistance, and anthropometrics in a large cohort of community-dwelling adults. Methods Associations of FGF23 with markers of inflammation [interleukin-6 (IL-6), IL-10, high sensitivity-CRP (hsCRP)], insulin utilization [resistin, adiponectin, homeostatic model assessment of insulin resistance (HOMA-IR)] and anthropometrics [BMI and waist circumference (WC)] were examined cross-sectionally in a 1,040 participants randomly selected from the Reason for Geographic and Racial Differences in Stroke (REGARDS) Study, a national study of black and white adults ≥45 years. Effect modification by race and CKD status was tested, and stratified models were analyzed accordingly. Results Median FGF23 concentration was 69.6 RU/ml (IQR: 53.2, 102.7). Higher quartiles of FGF23 were associated with higher mean concentrations of IL-6, IL-10, hsCRP and resistin (P trend<0.001 for all). There were no significant differences in HOMA-IR, adiponectin concentrations, BMI, or WC across FGF23 quartiles in the crude analyses. CKD significantly modified the relationships between FGF23 and inflammatory markers, HOMA-IR, BMI and WC (P ≤ 0.01 for all). In linear regression models adjusted for sociodemographic and clinical variables, FGF23 was positively associated with IL-6, hsCRP, IL-10, HOMA-IR, BMI and WC in individuals without CKD, but not among individuals with CKD. Additionally, FGF23 was positively associated with resistin irrespective of CKD status. Conclusions Elevated FGF23 concentrations may be considered a biomarker for decline in metabolic function among individuals with normal kidney function.
Native support of multi-tenancy in RDBMS for software as a service

Software as a Service (SaaS) facilitates acquiring a huge number of small tenants by providing low service fees. To achieve low service fees, it is essential to reduce costs per tenant. For this, consolidating multiple tenants onto a single relational schema instance turned out beneficial because of low overheads per tenant and scalable manageability. This approach implements data isolation between tenants, per-tenant schema extension and further tenant-centric data management features in application logic. This is complex, disables some optimization opportunities in the RDBMS and represents a conceptual misstep with Separation of Concerns in mind. Therefore, we contribute first features of a RDBMS to support tenant-aware data management natively. We introduce tenants as first-class database objects and propose the concept of a tenant context to isolate a tenant from other tenants. We present a schema inheritance concept that allows sharing a core application schema among tenants while enabling schema extensions per tenant. Finally, we evaluate a preliminary implementation of our approach.
FIRST RESULTS FROM THE 3D-HST SURVEY: THE STRIKING DIVERSITY OF MASSIVE GALAXIES AT z > 1

We present first results from the 3D-HST program, a near-IR spectroscopic survey performed with the Wide Field Camera 3 (WFC3) on the HST. We have used 3D-HST spectra to measure redshifts and Hα equivalent widths (EWHα) for a complete, stellar mass-limited sample of 34 galaxies at 1 < z < 1.5 with Mstar > 1011 M☉ in the COSMOS, GOODS, and AEGIS fields. We find that a substantial fraction of massive galaxies at this epoch are forming stars at a high rate: the fraction of galaxies with EWHα >10 Å is 59%, compared to 10% among Sloan Digital Sky Survey galaxies of similar masses at z = 0.1. Galaxies with weak Hα emission show absorption lines typical of 2–4 Gyr old stellar populations. The structural parameters of the galaxies, derived from the associated WFC3 F140W imaging data, correlate with the presence of Hα; quiescent galaxies are compact with high Sérsic index and high inferred velocity dispersion, whereas star-forming galaxies are typically large two-armed spiral galaxies, with low Sérsic index. Some of these star-forming galaxies might be progenitors of the most massive S0 and Sa galaxies. Our results challenge the idea that galaxies at fixed mass form a homogeneous population with small scatter in their properties. Instead, we find that massive galaxies form a highly diverse population at z > 1, in marked contrast to the local universe.
Iron Supply Affects Anthocyanin Content and Related Gene Expression in Berries of Vitis vinifera cv. Cabernet Sauvignon

Anthocyanins are important compounds for red grape and red wine quality, and can be influenced by supply of nutrients such as nitrogen, phosphorus, potassium, zinc, and iron. The present work aims to gain a better understanding of the effect of iron supply on anthocyanins concentration in grape berries. To this end, own-rooted four-year-old Cabernet Sauvignon grapevines (Vitis vinifera) were fertigated every three days with 0, 23, 46, 92, and 184 μM iron (Fe) from ferric ethylenediamine di (o-hydroxyphenylacetic) acid (Fe-EDDHA) in a complete nutrient solution. Fe deficiency or excess generally led to higher concentrations of titratable acidity and skin/berry ratio, and to lower reducing sugar content, sugar/acid ratio, pH, berry weight, and concentration of anthocyanins. Most of the individual anthocyanins detected in this study, except cyanidin-3-O-glucoside, delphinidin-3-O-glucoside, and cyanidin-3-O-(6-O-coumaryl)-glucoside, in moderate Fe treatment (46 μM) grapes were significantly higher than those of other treatments. Genes encoding chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), leucoanthocyanidin dioxygenase (LDOX), and anthocyanin O-methyltransferase (AOMT) exhibited higher transcript levels in berries from plants cultivated with 46 μM Fe compared to the ones cultivated with other Fe concentrations. We suggest that grape sugar content, anthocyanins content, and transcriptions of genes involved in anthocyanin biosynthesis were correlated with Fe supply concentrations.
The effects of screen-size and communication modality on psychology of mobile device users

Does screen-size matter in mobile devices? There appears to be a move toward larger screens, with recent launches of Apple's iPad and Samsung's Galaxy Tab, but do these devices undercut the perceived mobility and affect user attitudes toward the technology? To answer these and related questions, the present study examines the effects of screen-size and communication modality (text vs. video) on mobile device users' perception of mobility and content as well as attitudes toward technology acceptance. Preliminary data from a between-subjects experiment show that smaller screen-size elicited greater perceived mobility while larger screen-size was key to greater enjoyment. News story in video format played a crucial role in providing greater enjoyment and newsworthiness of the news story while news in text format was perceived to be easier to use on a mobile device. Design implications and limitations are discussed, as we prepare for a constructive replication.
Exploring the role of individual differences in information visualization

In this paper, we describe a user study aimed at evaluating the effectiveness of two different data visualization techniques developed for describing complex environmental changes in an interactive system designed to foster awareness in sustainable development. While several studies have compared alternative visualizations, the distinguishing feature of our research is that we try to understand whether individual user differences may be used as predictors of visualization effectiveness in choosing among alternative visualizations for a given task. We show that the cognitive ability known as perceptual speed can predict which one of our target visualizations is most effective for a given user. This result suggests that tailored visualization selection can be an effective way to improve user performance.
Balanced dynamics and convection in the tropical troposphere

This paper presents a conceptual picture of balanced tropical tropospheric dynamics inspired by recent observations. The most important factor differentiating the tropics from middle and higher latitudes is the absence of baroclinic instability; upward motion occurs primarily via deep convective processes. Thus, convection forms an integral part of large‐scale tropical motions. Since convection itself is small‐scale and chaotic in detail, predictability lies in uncovering the hidden hands that guide the average behavior of convection. Two appear, balanced dynamics and thermodynamic constraints. Contrary to conventional expectations, balanced dynamics plays a crucial role in the tropical atmosphere. However, due to the smallness of the Coriolis parameter there, nonlinear balance is more important in the tropics than at higher latitudes. Three thermodynamic constraints appear to play an important role in governing the average behavior of convection outside of the cores of tropical storms. First, convection is subject to control via a lower tropospheric buoyancy quasi‐equilibrium process, wherein destabilization of the lower troposphere by nonconvective processes is balanced by convective stabilization. Second, the production of precipitation is extraordinarily sensitive to the saturation fraction of the troposphere. Third, “moisture quasi‐equilibrium” governs the saturation fraction, with moister atmospheres being associated with smaller moist convective instability. The moist convective instability is governed by the balanced thermodynamic response to the pattern of potential vorticity, which in turn is slowly modified by convective and radiative heating. The intricate dance between these dynamic and thermodynamic processes leads to complex behavior of the tropical atmosphere in ways that we are just beginning to understand.
In Vivo Cell Wall Loosening by Hydroxyl Radicals during Cress Seed Germination and Elongation Growth1[W][OA]

Loosening of cell walls is an important developmental process in key stages of the plant life cycle, including seed germination, elongation growth, and fruit ripening. Here, we report direct in vivo evidence for hydroxyl radical (·OH)-mediated cell wall loosening during plant seed germination and seedling growth. We used electron paramagnetic resonance spectroscopy to show that ·OH is generated in the cell wall during radicle elongation and weakening of the endosperm of cress (Lepidium sativum; Brassicaceae) seeds. Endosperm weakening precedes radicle emergence, as demonstrated by direct biomechanical measurements. By 3H fingerprinting, we showed that wall polysaccharides are oxidized in vivo by the developmentally regulated action of apoplastic ·OH in radicles and endosperm caps: the production and action of ·OH increased during endosperm weakening and radicle elongation and were inhibited by the germination-inhibiting hormone abscisic acid. Both effects were reversed by gibberellin. Distinct and tissue-specific target sites of ·OH attack on polysaccharides were evident. In vivo ·OH attack on cell wall polysaccharides were evident not only in germinating seeds but also in elongating maize (Zea mays; Poaceae) seedling coleoptiles. We conclude that plant cell wall loosening by ·OH is a controlled action of this type of reactive oxygen species.
Hospital staffing, organization, and quality of care: Cross-national findings.

OBJECTIVE To examine the effects of nurse staffing and organizational support for nursing care on nurses' dissatisfaction with their jobs, nurse burnout, and nurse reports of quality of patient care in an international sample of hospitals. DESIGN Multisite cross-sectional survey SETTING Adult acute-care hospitals in the U.S. (Pennsylvania), Canada (Ontario and British Columbia), England and Scotland. STUDY PARTICIPANTS 10319 nurses working on medical and surgical units in 303 hospitals across the five jurisdictions. INTERVENTIONS None Main outcome measures: Nurse job dissatisfaction, burnout, and nurse-rated quality of care. RESULTS Dissatisfaction, burnout and concerns about quality of care were common among hospital nurses in all five sites. Organizational/managerial support for nursing had a pronounced effect on nurse dissatisfaction and burnout, and both organizational support for nursing and nurse staffing were directly, and independently, related to nurse-assessed quality of care. Multivariate results imply that nurse reports of low quality care were three times as likely in hospitals with low staffing and support for nurses as in hospitals with high staffing and support. CONCLUSION Adequate nurse staffing and organizational/managerial support for nursing are key to improving the quality of patient care, to diminishing nurse job dissatisfaction and burnout and, ultimately, to improving the nurse retention problem in hospital settings.
Information spreading in context

Information spreading processes are central to human interactions. Despite recent studies in online domains, little is known about factors that could affect the dissemination of a single piece of information. In this paper, we address this challenge by combining two related but distinct datasets, collected from a large scale privacy-preserving distributed social sensor system. We find that the social and organizational context significantly impacts to whom and how fast people forward information. Yet the structures within spreading processes can be well captured by a simple stochastic branching model, indicating surprising independence of context. Our results build the foundation of future predictive models of information flow and provide significant insights towards design of communication platforms.
Severe Respiratory Syncytial Virus Bronchiolitis in Infants Is Associated with Reduced Airway Interferon Gamma and Substance P

Background Severe human respiratory syncytial virus (hRSV) bronchiolitis in previously well infants may be due to differences in the innate immune response to hRSV infection. Aim: to determine if factors mediating proposed mechanisms for severe bronchiolitis differ with severity of disease. Methodology/Principle Findings 197 infants admitted to hospital with hRSV bronchiolitis were recruited and grouped according to no oxygen requirement (n = 27), oxygen dependence (n = 114) or mechanical ventilation (n = 56). We collected clinical data, nasopharyngeal aspirate (NPA) and if ventilated bronchoalveolar lavage (BAL). Interferon-gamma (IFN-γ), substance P (SP), interleukin 9 (IL-9), urea and hRSV load, were measured in cell free supernatant from NPA and BAL. Multivariate analysis compared independent effects of clinical, virological and immunological variables upon disease severity. IFN-γ and SP concentrations were lower in NPA from infants who required oxygen or mechanical ventilation. Viral load and IL-9 concentrations were high but did not vary with severity of disease. Independent predictors of severe disease (in diminishing size of effect) were low weight on admission, low gestation at birth, low NPA IFN-γ and NPA SP. Nasal airway sampling appears to be a useful surrogate for distal airway sampling since concentrations of IFN-γ, SP, IL-9 and viral load in NPA correlate with the same in BAL. Conclusions Our data support two proposed mechanisms for severe hRSV disease; reduced local IFN-γ response and SP mediated inflammation. We found large amounts of hRSV and IL-9 in airways secretions from the upper and lower respiratory tract but could not associate these with disease severity.
Reinforced Concrete Deep Beams

Design of reinforced concrete deep beams, F.K. Kong and M.Chemrouk strength and behaviour of deep beams, M.D.Kotsovos deep beams with web openings, S.P.Ray continuous deep beams, D.M. Rogowsky ranged deep beams, M.T. Solanki deep beams under top and bottom loadings, A.R. Cusens shear strength prediction - the softened truss model, T.C. Hsu and S.T. Man shear strength prediction - plastic method finite element analysis, Y.K. Cheung and M.C. Chan stability and strength of slender concrete deep beams, F.K. Kong and H.H. A.Wong.
Classification of Images Using Support Vector Machines

Support Vector Machines (SVMs) are a relatively new supervised classification technique to the land cover mapping community. They have their roots in Statistical Learning Theory and have gained prominence because they are robust, accurate and are effective even when using a small training sample. By their nature SVMs are essentially binary classifiers, however, they can be adopted to handle the multiple classification tasks common in remote sensing studies. The two approaches commonly used are the One-Against-One (1A1) and One-Against-All (1AA) techniques. In this paper, these approaches are evaluated in as far as their impact and implication for land cover mapping. The main finding from this research is that whereas the 1AA technique is more predisposed to yielding unclassified and mixed pixels, the resulting classification accuracy is not significantly different from 1A1 approach. It is the authors conclusions that ultimately the choice of technique adopted boils down to personal preference and the uniqueness of the dataset at hand.
Computational approach for investigating nuclear transport of Trypanosoma brucei

Trypanosoma brucei (T. brucei) is one of the frequent pathogens in human blood. To date, the nuclear transport in this parasite is still unelucidated. Thus, the present study is carried out to identify and characterize the T. brucei homologues of nuclear transport components using a series of bioinformatics tools. Prediction using computational approach has successfully identified 24 T. brucei homologues to be involved in the nuclear transport with the presence of functional domains and motifs such as GTP-binding domain, NUP C terminal domain, ARM repeat, HEAT repeat, CAS/CSE repeat, RCC1 repeat, Importin B N-terminal domain and Exportin domain. The mining protein interaction network has increased our system-level understanding of parasite nuclear transport. Therefore, our in silico approach has enabled rapid screening and identification of nuclear transport components for further characterization in the laboratory.