Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

Abstract Chronic physical exercises may be beneficial to modulate appetite hormones as acyl-ghrelin (orexigenic) and obestatin (anorexigenic) in chronic kidney disease (CKD) patients; however, there are no data about the effects of acute exercises on these hormones. Thus, the aim of the present study was to assess the effect of acute resistance exercise on appetite hormones (acyl-ghrelin and obestatin) of patients undergoing hemodialysis (HD). Twenty-five patients (44.7 ± 12.9 years, 68% women) on regular HD program were enrolled into two groups, 16 patients performed exercises and 9 patients comprised the control group. The patients performed the exercises in both lower limbs with ankle-cuffs and elastic bands, 30 min after the initiation of hemodialysis session. Blood samples of both the groups were drawn in the morning before and after 30 min with exercise session (exercise group) and, before and after the same time without exercise (control group). Acyl-ghrelin and obestatin plasma levels were measured using an enzyme immunometric assay. Acyl-ghrelin plasma levels did not change in both the groups. However, when stratified by gender the acyl-ghrelin increased significantly right after exercise in men [32.1 pg/mL (25.6–41.2) to 46.0 pg/mL (39.0–59.5)] (p = 0.04). Obestatin plasma levels reduced after a single bout of exercise and changes remained significantly when the sample was stratified by gender. There was no change in obestatin plasma levels in control group. A single bout of resistance exercise seems to modulate the levels of appetite hormones in HD patients.
Single-Model Encoder-Decoder with Explicit Morphological Representation for Reinflection

Morphological reinflection is the task of generating a target form given a source form, a source tag and a target tag. We propose a new way of modeling this task with neural encoder-decoder models. Our approach reduces the amount of required training data for this architecture and achieves state-of-the-art results, making encoder-decoder models applicable to morphological reinflection even for low-resource languages. We further present a new automatic correction method for the outputs based on edit trees.
Holocene aridification of India

Spanning a latitudinal range typical for deserts, the Indian peninsula is fertile instead and sustains over a billion people through monsoonal rains. Despite the strong link between climate and society, our knowledge of the long‐term monsoon variability is incomplete over the Indian subcontinent. Here we reconstruct the Holocene paleoclimate in the core monsoon zone (CMZ) of the Indian peninsula using a sediment core recovered offshore from the mouth of Godavari River. Carbon isotopes of sedimentary leaf waxes provide an integrated and regionally extensive record of the flora in the CMZ and document a gradual increase in aridity‐adapted vegetation from ∼4,000 until 1,700 years ago followed by the persistence of aridity‐adapted plants after that. The oxygen isotopic composition of planktonic foraminiferGlobigerinoides ruberdetects unprecedented high salinity events in the Bay of Bengal over the last 3,000 years, and especially after 1,700 years ago, which suggest that the CMZ aridification intensified in the late Holocene through a series of sub‐millennial dry episodes. Cultural changes occurred across the Indian subcontinent as the climate became more arid after ∼4,000 years. Sedentary agriculture took hold in the drying central and south India, while the urban Harappan civilization collapsed in the already arid Indus basin. The establishment of a more variable hydroclimate over the last ca. 1,700 years may have led to the rapid proliferation of water‐conservation technology in south India.
Gravity wave initiation of equatorial spread F: A case study

Jicamarca radar backscatter maps were made during four consecutive nights in March 1979. Two of these maps displayed single towering plumes extending to nearly 1000-km altitude. On a third night, discussed in detail here, six plumes were generated in clear association with a nearly sinusoidal oscillation of the height of the bottomside of the F layer. The vertical amplitude of the oscillation was several hundred kilometers, and the period about 100 minutes. The plumes were generated either when the bottomside of the F layer was at the highest altitude or in the descending phase of the motion. Families of curves are presented which correspond to the solution of the dispersion relation for gravity waves capable of initiating the observed bottomside oscillations via the spatial resonance mechanism. We conclude that the solutions thus derived are reasonable and present a criterion for how well matched the gravity wave phase velocity and plasma drift have to be to produce a given perturbation in the ionization density. This criterion indicates that although initiation by a gravity wave seems likely, the gravity wave interaction cannot yield the large displacements observed without further amplification by the Rayleigh-Taylor instability. Finally, we show that the preferential generation of plumes during the descending phase of the F layer height oscillation can be explained by a generalized Rayleigh-Taylor instability operating on the distorted ionosphere with the destabilizing effects of gravity, a zonal electric field, and a zonal neutral wind included.
Snacking patterns among adolescents: a comparison of type, frequency and portion size between Britain in 1997 and Northern Ireland in 2005

Despite the potential link between snack food intake and obesity and the reportedly high prevalence of snacking among adolescents, adolescent snack food patterns (types of foods consumed, frequency and portion size) have not been extensively examined. This study examines these issues using data on the snacking patterns of adolescents aged 13–16 years who took part in the 1997 National Diet and Nutrition Survey (NDNS) and that from a Northern Irish (NI) cohort of adolescents collected 8 years later, in 2005. Overall energy intake was significantly higher in the NI adolescents in 2005 compared with the NDNS adolescents in 1997 (P < 0·01). Consequently, energy intake from snacks was significantly higher in the NI cohort (P < 0·01) and a trend for a higher % energy intake from snacks compared with the NDNS group was observed (median 32·5 % v. 29·8 %, respectively). Sugar-sweetened carbonated and soft drinks remained the most popular choice of snack over this 8-year period; however, both the portion size consumed and frequency of consumption were significantly higher among the adolescents in 2005 compared with those in 1997 (P = 0·022 and P = 0·014, respectively). Despite the lower popularity, and correspondingly lower frequency of milks and beverages, the portion size of both food groups was significantly higher among the adolescents in 2005 compared with those in 1997 (P < 0·001 and P = 0·007, respectively). These findings may provide scope for policy interventions to place particular emphasis on reducing typical portion sizes consumed of popular snack choices, in particular high-energy carbonated and soft drinks, among UK adolescents.
Support for an “A‐type” Pangea reconstruction from high‐fidelity Late Permian and Early to Middle Triassic paleomagnetic data from Argentina

[1] A major disparity is observed between the late Paleozoic-early Mesozoic apparent polar wander paths (APWPs) of Laurussia and Gondwana when the landmasses are re-assembled in a conventional “A-type” Pangea. This discrepancy has endured from the earliest paleomagnetic reconstructions of the supercontinent, and has prompted discussions of non-dipole paleomagnetic fields and alternative paleogeographic models. Here we report on a joint paleomagnetic-geochronologic study of Late Permian and Early to Middle Triassic volcanic and volcaniclastic rocks from Argentina, which demonstrates support for an A-type model, without requiring modification to the geocentric axial dipole hypothesis. New SHRIMP U-Pb and 40Ar-39Ar isotopic dating has reinforced the inferred age of the sequences, which we estimate at ∼264 Ma (Upper Choiyoi Group) and ∼245 Ma (Puesto Viejo Group). Field-stability tests demonstrate that the volcanic rocks are carrying early/primary magnetizations, which yield paleopoles: 73.7°S, 315.6°E, A95: 4.1°, N: 40 (Upper Choiyoi) and 76.7°S, 312.4°E, A95: 7.3°, N: 14 (Puesto Viejo). A comprehensive magnetic fabric analysis is used to evaluate structural restorations and to correct for magnetization anisotropy. The paleomagnetic results derived from volcaniclastic rocks are interpreted to be affected by inclination shallowing, and corrections are discussed. A comparison of these new results with the existing Permian-Triassic paleomagnetic data from Gondwana suggests the presence of widespread bias in the latter. We contend that such bias can explain the observed APWP disparity, at least for Late Permian-Middle Triassic time, and that alternative paleogeographic reconstructions or non-dipole paleomagnetic fields do not need to be invoked to resolve the discrepancy.
Learning to Paraphrase: An Unsupervised Approach Using Multiple-Sequence Alignment

We address the text-to-text generation problem of sentence-level paraphrasing --- a phenomenon distinct from and more difficult than word- or phrase-level paraphrasing. Our approach applies multiple-sequence alignment to sentences gathered from unannotated comparable corpora: it learns a set of paraphrasing patterns represented by word lattice pairs and automatically determines how to apply these patterns to rewrite new sentences. The results of our evaluation experiments show that the system derives accurate paraphrases, outperforming baseline systems.
Time to abandon the Manning equation?

River flow is retarded by the frictional resistance of the rough bed and banks of the channel. For any given channel geometry, channel slope, and water discharge an increase in frictional resistance causes deeper and slower flow, with consequences for flood risk, aquatic habitat, shear stress and bed-material transport. Flow resistance is ultimately due to blocking by, and drag on, topographic irregularities at all scales from individual pebbles to buildings on a floodplain. Modern computer power has enabled three-dimensional (3D) numerical modelling of the physics if sufficient topographic detail is available (Lane, 2005), but for many geomorphological purposes only the bulk flow properties of a reach are required: cross-sectionally averaged depth, velocity, and shear stress. The effect of friction on these is quantified through simple equations which predict mean velocity (V) from hydraulic radius (R, a mean depth in most rivers) and channel slope (S). There are many such equations, and preferences differ somewhat between countries and disciplines, but by far the best-known and most widely-used overall is what in English-speaking countries is known as the Manning equation:
Opportunity rover localization and topographic mapping at the landing site of Meridiani Planum, Mars

[1] This paper presents the results of Mars topographic mapping and lander and rover localization for the Opportunity rover at Meridiani Planum during the Mars Exploration Rover (MER) 2003 mission. By Sol 458, the Opportunity rover traversed a distance of 5.20 km. We localized the lander using two-way Doppler radio positioning and cartographic triangulation of craters visible in both orbital and ground images. Additional high-resolution orbital images were taken to verify the determined lander position. Visual odometry and bundle adjustment techniques were applied to overcome wheel slippages, azimuthal angle drift, and other navigation errors (as large as 21% within Eagle crater). In addition, orbit-to-ground image-based adjustment was applied to correct rover location errors where bundle adjustment was not applicable. We generated timely topographic products, including orthoimages, digital terrain models (DTMs), three-dimensional (3-D) crater models, and rover traverse maps. In particular, detailed 3-D terrain models of major features, such as Endurance crater, have been generated using multisite panoramic stereo images based on bundle adjustment and wide baseline stereo technique.
Cross-Layer Early Reliability Evaluation for the Computing cOntinuum

Advanced multifunctional computing systems realized in forthcoming technologies hold the promise of a significant increase of the computational capability that will offer end-users ever improving services and functionalities (e.g., next generation mobile devices, cloud services, etc.). However, the same path that is leading technologies toward these remarkable achievements is also making electronic devices increasingly unreliable, posing a threat to our society that is depending on the ICT in every aspect of human activities. Reliability of electronic systems is therefore a key challenge for the whole ICT technology and must be guaranteed without penalizing or slowing down the characteristics of the final products. CLERECO EU FP7 (GA No. 611404) research project addresses early accurate reliability evaluation and efficient exploitation of reliability at different design phases, since these aspects are two of the most important and challenging tasks toward this goal.
PEERING THROUGH THE DUST: NuSTAR OBSERVATIONS OF TWO FIRST-2MASS RED QUASARS

Some reddened quasars appear to be transitional objects in the paradigm of merger-induced black hole growth/galaxy evolution, where a heavily obscured nucleus starts to be unveiled by powerful quasar winds evacuating the surrounding cocoon of dust and gas. Hard X-ray observations are able to peer through this gas and dust, revealing the properties of circumnuclear obscuration. Here, we present NuSTAR and XMM-Newton/Chandra observations of FIRST-2MASS-selected red quasars F2M 0830+3759 and F2M 1227+3214. We find that though F2M 0830+3759 is moderately obscured (NH,Z = (2.1 ± 0.2) × 1022 cm−2) and F2M 1227+3214 is mildly absorbed ( N H , Z = 3.4 − 0.7 + 0.8 × 10 21 ? > cm−2) along the line of sight, heavier global obscuration may be present in both sources, with N H , S = 3.7 − 2.6 + 4.1 × 10 23 ? > cm−2 and <5.5 × 1023 cm−2 for F2M 0830+3759 and F2M 1227+3214, respectively. F2M 0830+3759 also has an excess of soft X-ray emission below 1 keV, which is well accommodated by a model where 7% of the intrinsic X-ray emission from the active galactic nucleus (AGN) is scattered into the line of sight. While F2M 1227+3214 has a dust-to-gas ratio (E(B – V)/NH) consistent with the Galactic value, the value of E(B – V)/NH for F2M 0830+3759 is lower than the Galactic standard, consistent with the paradigm that the dust resides on galactic scales while the X-ray reprocessing gas originates within the dust sublimation zone of the broad-line region. The X-ray and 6.1 μm luminosities of these red quasars are consistent with the empirical relations derived for high-luminosity, unobscured quasars, extending the parameter space of obscured AGNs previously observed by NuSTAR to higher luminosities.
Enhanced aggressiveness of benzopyrene‐induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6)

PACE4 (PCSK6) is a proprotein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco‐associated carcinogen benzo[a]pyrene (B(a)P) we investigated whether transgenic mice in which this PC is targeted to the epidermis (K5‐PACE4) may be more susceptible to B(a)P complete carcinogenesis than wild type (WT) mice. In an in vitro experiment, using cell lines derived from skin tumors obtained after B(a)P treatment, we observed that PACE4 overexpression and activity accounts for an increased proliferation rate, exaggerated sensitivity to the PC inhibitor CMK, and interference with IGF‐1R autophosphorylation. Squamous cell carcinomas, obtained from K5‐PACE4 mice subjected to complete chemical carcinogenesis, were characterized by a 50% increase in cell proliferation, when compared with similar tumors from WT mice. In addition, tumors from K5‐PACE4 mice showed deeper invasion into the underlying dermis. Thus, mice overexpressing PACE4 exhibited tumors of increased growth rate and invasive potential when exposed to the human carcinogen B(a)P, further supporting the significance of PCs in tumor growth and progression. © 2014 Wiley Periodicals, Inc.
Sequence of Thrusting Within A Thick‐Skinned Tectonic Wedge: Evidence From 40Ar/39Ar and Rb‐Sr Ages From the Austroalpine Nappe Complex of the Eastern Alps

The sequence of thrusting within a regional‐scale Alpine thick‐skinned tectonic wedge has been constrained by Rb‐Sr and 40Ar/39Ar dating of whole‐rock, constituent white mica and biotite from structural units of the Austroalpine Nappe Complex, Eastern Alps (Austria). Preservation of Variscan and pre‐Variscan isotopic signatures in pre‐Alpine basement units indicates a non‐penetrative metamorphic Alpine overprint. Alpine nappe assembly and accompanying ductile deformation occurred during maintenance of lower greenschist‐facies metamorphic conditions (c. 300°–450°C). Analyses from greenschist‐facies metamorphic mylonites and penetratively ductile deformed cover sequences display decreasing 40Ar/39Ar plateau ages structurally downward. Thrusting and accompanied ductile deformation commenced at c. 100–90 Ma in the uppermost structural levels. Footwall fault propagation effected internal deformation and out‐of‐sequence thrusting within intermediate structural levels at c. 95–80 Ma. This was contemporaneous with regional exhumation and cooling of deeper crustal basement units at c. 88–82 Ma and was associated with extension and strike‐slip faulting, leading to the formation of synorogenic sedimentary basins. Additional foot‐wall thrust propagation was associated with ductile deformation within lowermost structural units at c. 80–70 Ma. The structural and new geochronologic results presented herein suggest that (1) the Austroalpine Nappe Complex represents a forward propagating thrust complex that formed as a result of footwall propagation of a master fault and associated piggyback transport of hangingwall structural units; (2) most parts of the Austroalpine block occupied a lower‐plate tectonic setting during Cretaceous tectonics subsequent to subduction of the Meliata‐Hallstatt ocean; and (3) the Austroalpine Nappe Complex had already been formed when subduction of Penninic oceanic domains was active.
Systematic reviews and meta-analyses of randomized trials : principles and pitfalls

Systematic reviews and meta-analyses allow for a more transparent and objective appraisal of the evidence. They may decrease the number of false-negative results and prevent delays in the introduction of effective interventions into clinical practice. However, as for any other tool, their misuse can result in severely misleading results. In this article, we discuss the main steps that should be taken when conducting systematic reviews and meta-analyses, namely the preparation of a review protocol, identification of eligible trials, and data extraction, pooling of treatment effects across trials, investigation of potential reasons for differences in treatment effects across trials, and complete reporting of the review methods and findings. We also discuss common pitfalls that should be avoided, including the use of quality assessment tools to derive summary quality scores, pooling of data across trials as if they belonged to a single large trial, and inappropriate uses of meta-regression that could result in misleading estimates of treatment effects because of regression to the mean or the ecological fallacy. If conducted and reported properly, systematic reviews and meta-analyses will increase our understanding of the strengths and weaknesses of the available evidence, which may eventually facilitate clinical decision making.
The 2001 Superoutburst of WZ Sagittae

We report the results of a worldwide campaign to observe WZ Sagittae during its 2001 superoutburst. After a 23 yr slumber at V = 15.5, the star rose within 2 days to a peak brightness of 8.2, and showed a main eruption lasting 25 days. The return to quiescence was punctuated by 12 small eruptions, of ∼1 mag amplitude and 2 day recurrence time; these “echo outbursts” are of uncertain origin, but somewhat resemble the normal outbursts of dwarf novae. After 52 days, the star began a slow decline to quiescence. Periodic waves in the light curve closely followed the pattern seen in the 1978 superoutburst: a strong orbital signal dominated the first 12 days, followed by a powerful common superhump at 0.05721(5) day, 0.92(8)% longer than Porb. The latter endured for at least 90 days, although probably mutating into a “late” superhump with a slightly longer mean period [0.05736(5) day]. The superhump appeared to follow familiar rules for such phenomena in dwarf novae, with components given by linear combinations of two basic frequencies: the orbital frequency ωo and an unseen low frequency Ω, believed to represent the accretion disk’s apsidal precession. Long time series reveal an intricate fine structure, with ∼20 incommensurate frequencies. Essentially all components occurred at a frequency nωo - mΩ, with m = 1, …, n. But during its first week, the common superhump showed primary components at nωo - Ω, for n = 1, 2, 3, 4, 5, 6, 7, 8, 9 (i.e., m = 1 consistently); a month later, the dominant power shifted to components with m = n - 1. This may arise from a shift in the disk’s spiral‐arm pattern, likely to be the underlying cause of superhumps. The great majority of frequency components are redshifted from the harmonics of ωo, consistent with the hypothesis of apsidal advance (prograde precession). But a component at 35.42 cycles day−1 suggests the possibility of a retrograde precession at a different rate, probably N = 0.13 ± 0.02 cycles day−1. The eclipses permit measuring the location and brightness of the mass‐transfer hot spot. The disk must be very eccentric and nearly as large as the white dwarf’s Roche lobe. The hot‐spot luminosity exceeds its quiescent value by a factor of up to 60. This indicates that enhanced mass transfer from the secondary plays a major role in the eruption.
Cost-effective condition-based maintenance using markov decision processes

Investigations conducted in several industries indicate that there is no direct relationship between equipment failure and equipment age in the majority of cases. Most failures are caused by events or conditions that occur during component operation and manufacturing processes. Therefore, optimal maintenance decisions should be based on the actual deterioration conditions of the components. Condition-Based Maintenance (CBM) is a methodology that strives to identify incipient faults before they become critical to enable more accurate planning of preventive actions. For the ultimate success of CBM methodology, we must have sound methods for modeling deterioration (the propagation of faulty conditions), the conditions and their effects, and the optimal selection and scheduling of inspections and preventive maintenance actions (the right action at the right time). In this paper, we present a generalized CBM model that can be applied to a wide range of applications. The CBM model includes a stochastic deterioration process, a set of maintenance actions and their effects, and a scheduled inspection policy that identifies the condition of deterioration. Using Markov Decision Processes (MDP), we provide an optimal cost-effective maintenance decision based on the condition revealed at the time of inspection. In addition, we present a procedure for finding optimal inspection schedules