Miracle-dz/UniFAR-FTUs huggingface dataset:
PROTEIN SECONDARY STRUCTURE PREDICTION USING SUPPORT VECTOR MACHINES, NUERAL NETWORKS AND GENETIC ALGORITHMS by ANJUM

Bioinformatics techniques to protein secondary structure prediction mostly depend on the information available in amino acid sequence. Support vector machines (SVM) have shown strong generalization ability in a number of application areas, including protein structure prediction. In this study, a new sliding window scheme is introduced with multiple windows to form the protein data for training and testing SVM. Orthogonal encoding scheme coupled with BLOSUM62 matrix is used to make the prediction. First the prediction of binary classifiers using multiple windows is compared with single window scheme, the results shows single window not to be good in all cases. Two new classifiers are introduced for effective tertiary classification. This new classifiers use neural networks and genetic algorithms to optimize the accuracy of the tertiary classifier. The accuracy level of the new architectures are determined and compared with other studies. The tertiary architecture is better than most available techniques. vector machine (SVM), tertiary classifier. iv ACKNOWLEDGEMENTS I wish to take this opportunity to thank many people without whom this thesis would not have been accomplished. First and foremost, I would like to thank my thesis advisor, Dr. Yanqing Zhang. I was able to achieve this task, with his help, guidance, encouragement, and the time that he has spent on directing my thesis. I also wish to thank my thesis committee members, Dr. Saeid Belkasim and Dr. Yingshu Li, for taking time to evaluate my simulation results and to review my thesis document. I would like to express my gratitude to Dr. Hyunsoo Kim from Georgia Tech, who helped me understand the PSSM profiling. I would like to thank my fellow department members and all my friends, who patiently listen to all my doubts and queries and helped me in many ways. Last but not least, I wish to express my gratitude to my parents and my brother who have pushed me this far. I most certainly should thank my husband Ashraf, who supported me and encouraged me even when I kept bugging him. Declaration I hereby declare that, except where otherwise indicated, this document is entirely my own work and has not been submitted in whole or in part to any other university.
Parents’ perceptions of physical activity experiences for their families and children with visual impairments

Acknowledging and understanding parental perceptions and experiences surrounding physical activity (PA) is crucial to promoting participation in PA for children with visual impairments (VI) given that parents strongly influence their children’s participation in physical activities. The purpose of this study was to understand parents’ perceptions regarding PA experiences for their family and children with VI. Participants in this study were parents of children with VI (N = 10) who took part in one-on-one semi-structured phone interviews that were transcribed and then analyzed through a thematic line-by-line analysis. Two themes emerged from the analysis of the data: (1) Health, Social, and Psychological Benefits and (2) Multifaceted Barriers. The parents in this study valued PA and had high PA expectations for their children; however, they struggled to overcome multiple barriers - most notably their limited ability to motivate their children to be physically active.
Primary caregiving fathers and breadwinning mothers: social psychological mechanisms underlying the division of family roles

Over recent decades there has been significant progress towards gender equality in the workplace and at home. Transformations in work and childcare domains have occurred for families in Western societies, including de-gendered parenting, in which childcare responsibilities are shared equally or assumed primarily by the father. Although these arrangements constitute a recent and rare phenomenon, this increase in proportion has been matched by an academic interest. Using quantitative data from traditional and role-reversed couples, this research aims to explore the social psychological mechanisms underlying non-normative behavioural choices, as well as the consequences for couples' relationship quality, well-being and life satisfaction. Traditional couples are those in which the mother bears primary responsibility for child care while the father is the main breadwinner. In non-traditional role-reversed couples the opposite occurs. A sample of 242 individual parents with children from birth to 12 years old, completed an extensive questionnaire. Involvement in work and childcare, social psychological variables, relationship and life satisfaction, perceptions of their division of responsibilities and socio-demographic characteristics were examined. Results show how social prescriptions and structural characteristics are limiting the intersection between the mother and the father role, and help us understand how both roles can be more similar than different. The findings also disclose how by being involved men are assisting women’s career and help make a distinction between traditional and role reversed women’s views of the appropriate parental role for men and women. Furthermore, the results contribute for a better understanding of how gender ideologies and non-essentialist perceptions differ between couples in different arrangements and how they relate to involvement in childcare and well-being, as well as the role of choice in well-being, life and marital satisfaction.
Predicting Purchase Decisions in Mobile Free-to-Play Games

Mobile digital games are dominantly released under the freemium business model, but only a small fraction of the players makes any purchases. The ability to predict who will make a purchase enables optimization of marketing efforts, and tailoring customer relationship management to the specific user's profile. Here this challenge is addressed via two models for predicting purchasing players, using a 100,000 player dataset: 1) A classification model focused on predicting whether a purchase will occur or not. 2) a regression model focused on predicting the number of purchases a user will make. Both models are presented within a decision and regression tree framework for building rules that are actionable by companies. To the best of our knowledge, this is the first study investigating purchase decisions in freemium mobile products from a user behavior perspective and adopting behavior-driven learning approaches to this problem.
Fungal Planet description sheets: 92–106

Novel species of microfungi described in the present study include the following from Australia: Diaporthe ceratozamiae on Ceratozamia robusta, Seiridium banksiae on Banksia marginata, Phyllosticta hymenocallidicola on Hymenocallis littoralis, Phlogicylindrium uniforme on Eucalyptus cypellocarpa, Exosporium livistonae on Livistona benthamii and Coleophoma eucalyptorum on Eucalyptus piperita. Several species are also described from South Africa, namely: Phoma proteae, Pyrenochaeta protearum and Leptosphaeria proteicola on Protea spp. , Phaeomoniella niveniae on Nivenia stokoei, Toxicocladosporium leucadendri on Leucadendron sp. and Scorias leucadendri on Leucadendron muirii. Other species include Myrmecridium phragmitis on Phragmites australis (Netherlands) and Camarographium carpini on Carpinus betulus (Russia). Furthermore, Pseudoidriella syzygii on Syzygium sp. represents a novel genus of hyphomycetes collected in Australia. Morphological and culture characteristics along with ITS DNA barcodes are provided for all taxa.
The Projected Three-Point Correlation Function: Theory and Observations

We report results for the angular three-point galaxy correlation function in the APM Galaxy Survey and compare them with theoretical expectations. For the first time, these measurements extend to sufficiently large scales to probe the weakly nonlinear regime. On large scales, the results are in good agreement with the predictions of nonlinear cosmological perturbation theory for a model with initially Gaussian fluctuations and linear power spectrum P(k) consistent with that inferred from the APM survey. These results reinforce the conclusion that large-scale structure is driven by nonlinear gravitational instability and that APM galaxies are relatively unbiased tracers of the mass on large scales; they also provide stringent constraints upon models with non-Gaussian initial conditions and strongly exclude the standard cold dark matter model.
Economically inactive, unemployed and employed suicides in Australia by age and sex over a 10-year period: what was the impact of the 2007 economic recession?

BACKGROUND Suicide is higher among economically inactive and unemployed persons than employed persons. This paper investigates differences in this relationship by sex and age over the period 2001 to 2010 in Australia. It also examines changes in suicide among employed, unemployed and economically inactive persons during the recession of 2007-09. METHOD Suicide data from the National Coroners Information System were utilised for this retrospective study. Negative binomial and Poisson regression was used to estimate the association between suicide and employment status and to investigate differences in suicide rates over the period of the recession (2007-09) compared with the year before the recession (2006). RESULTS Results suggest that during 2001-10 economically inactive/unemployed males had a suicide rate ratio (RR) of 4.62 [95% confidence interval (CI) 4.10, 5.19; P<0.001] compared with employed males (RR=1.00), whereas economically inactive/unemployed females had a suicide RR of 8.44 compared with employed females (95% CI 7.38, 9.67; P<0.001). There was an increase in suicide among both employed (7% rise in 2007, P=0.003) and economically inactive/unemployed males during the GFC (22% in 2008, P<0.001). Suicide also increased among economically inactive/unemployed females (12% in 2007, P=0.03; 19% in 2008, P=0.001) but not among employed females. CONCLUSIONS These results suggest the need for adequate policy and social welfare responses to ameliorate the effects of the economic recession on the working age population. Particularly, these should target unemployed and economically inactive men and women in Australia, who may be at higher risk of suicide than previously thought.
PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene.

BACKGROUND Ovulation induction treatment with metformin, either alone or in combination with clomiphene citrate (CC), remains controversial even though previous randomized trials have examined this. METHODS A double blinded multi-centre randomized trial was undertaken including 171 women with anovulatory or oligo-ovulatory polycystic ovary syndrome. Women with high body mass index (BMI) > 32 kg/m(2) received placebo ('standard care') or metformin; women with BMI < or = 32 kg/m(2) received CC ('standard care'), metformin or both. Treatment continued for 6 months or until pregnancy was confirmed. Primary outcomes were clinical pregnancy and live birth. RESULTS For women with BMI > 32 kg/m(2), clinical pregnancy and live birth rates were 22% (7/32) and 16% (5/32) with metformin, 15% (5/33) and 6% (2/33) with placebo. For women with BMI < or = 32 kg/m(2), clinical pregnancy and live birth rates were 40% (14/35) and 29% (10/35) with metformin, 39% (14/36) and 36% (13/36) with CC, 54% (19/35) and 43% (15/35) with combination metformin plus CC. CONCLUSIONS There is no evidence that adding metformin to 'standard care' is beneficial. Pregnancy and live birth rates are low in women with BMI > 32 kg/m(2) whatever treatment is used, with no evidence of benefit of metformin over placebo. For women with BMI < or = 32 kg/m(2) there is no evidence of significant differences in outcomes whether treated with metformin, CC or both. ClinicalTrials.gov number NCT00795808; trial protocol accepted for publication November 2005: Johnson, Aust N Z Journal Obstet Gynaecol 2006;46:141-145.
Smart girls : a deconstructive discourse analysis of smartness

This project is a deconstructive discourse analysis of smart girlhood. From a feminist post structural framework, with a focus on discourse and performative identity, I scrutinize three . dominant discourses of smartness that are prevalent and academic and popular press. These constructions frame smart girls as being either Losers, Have-It-All Girls, or Imposters. By conducting semi-structured group interviews with six self-identified smart girls, I explore the question of how smart girls perform their smart girl identities in their current sociocultural context. After analyzing the data from the group interviews, I outline five themes that seem to be prevalent in the stories told by the smart girls in this thesis. Finally, I discuss how the performative identities of the smart girls in my thesis appear to be much more complex, multiple and rhizomatic than the discourses under review allow.
Bluetooth Performance Analysis in Wireless Personal Area Networks

In this work performance results of Bluetooth v2.0+ EDR are presented. Measurement of file transfer delay (FTD) is done with variable file size and variable distance between sender and receiver, in an indoor environment. In this scenario the presence of obstacles between nodes are almost inevitable, hence a comparison of FTD with and without a physical obstacle is presented. FTD is a very useful metric as it gives the overall performance evaluation. The knowledge of this metric is fundamental for the development of multimedia applications, as real time communication is an important constraint, so minimum delays should be guaranteed . The results show that the delay average in the transfer of files is a lineal function with file size and the distance between sender and receiver. The importance to study and analyze Bluetooth Technology is that it is already installed in hundreds of millions of devices, such as cell phones, PDA's, etc. Therefore BT is very attractive for ubiquitous computing with multimedia capabilities.
Intravenous IgG: supertherapy for myocarditis and acute dilated cardiomyopathy.

To the Editor: We read with great interest the article by McNamara et al1 on intravenous immunoglobulin (IgG) therapy for myocarditis and acute dilated cardiomyopathy (DCM). There is as yet no general agreement of effective treatment of myocarditis and acute DCM. These workers are to be congratulated for conducting a well-designed clinical study of adult patients with NYHA class III to IV heart failure, based on previously published clinical2 and experimental3 experience. We would like to stress 3 points that we consider crucial in our understanding of the significance of this treatment. The first is related to the presence of preceding or associated infectious manifestations (ie, fever, pleurodynia, myalgia, and upper respiratory tract symptoms). This strongly suggests that myocarditis is …
Release of poly a(+) messenger RNA from rat liver rough microsomes upon disassembly of bound polysomes

Several procedures were used to disassemble rat liver rough microsomes (RM) into ribosomal subunits, mRNA, and ribosome-stripped membrane vesicles in order to examine the nature of the association between the mRNA of bound polysomes and the microsomal membranes. The fate of the mRNA molecules after ribosome release was determined by measuring the amount of pulse-labeled microsomal RNA in each fraction which was retained by oligo-dT cellulose or by measuring the poly A content by hybridization to radioactive poly U. It was found that ribosomal subunits and mRNA were simultaneously released from the microsomal membranes when the ribosomes were detached by: (a) treatment with puromycin in a high salt medium containing Mg++, (b) resuspension in a high salt medium lacking Mg++, and (c) chelation of Mg++ by EDTA or pyrophosphate. Poly A-containing mRNA fragments were extensively released from RM subjected to a mild treatment with pancreatic RNase in a medium of low ionic strength. This indicates that the 3' end of the mRNA is exposed on the outer microsomal surface and is not directly bound to the membranes. Poly A segments of bound mRNA were also accessible to [(3)H] poly U for in situ hybridization in glutaraldehyde-fixed RM. Rats were treated with drugs which inhibit translation after formation of the first peptide bonds or interfere with the initiation of protein synthesis. After these treatments inactive monomeric ribosomes, as well as ribosomes bearing mRNA, remained associated with their binding sites in microsomes prepared in media of low ionic strength. However, because there were no linkages provided by nascent chains, ribosomes, and mRNA, molecules were released from the microsomal membranes without the need of puromycin, by treatment with a high salt buffer containing Mg++. Thus, both in vivo and in vitro observations are consistent with a model in which mRNA does not contribute significantly to the maintenance of the interaction between bound polysomes and endoplasmic reticulum membranes in rat liver hepatocytes.
Stability of warped AdS3 vacua of topologically massive gravity

AdS3 vacua of topologically massive gravity (TMG) have been shown to be perturbatively unstable for all values of the coupling constant except the chiral point μl = 1. We study the possibility that the warped vacua of TMG, which exist for all values of μ, are stable under linearized perturbations. In this paper, we show that spacelike warped AdS3 vacua with Compere-Detournay boundary conditions are indeed stable in the range μl>3. This is precisely the range in which black hole solutions arise as discrete identifications of the warped AdS3 vacuum. The situation somewhat resembles chiral gravity: although negative energy modes do exist, they are all excluded by the boundary conditions, and the perturbative spectrum solely consists of boundary (pure large gauge) gravitons.
Prevalence of enterotoxigenic Clostridium perfringens in foods of animal origin, Guwahati, India

An investigation was carried out from August 2010 to February 2011 to isolate Clostridium perfringens from foods of animal origin and detect the presence of enterotoxin gene in the isolates in Guwahati, India. A total of 400 food samples comprising 50 each of chevon, pork, fish, beef and liquid raw milk, curd, pasteurized milk powder, pasteurized liquid milk and ice cream were screened for the presence of Clostridium perfringens. A total of 33 food samples were tested positive for the presence of the organism. Among the 33 isolates of C. perfringens, 5(15.15%) were found positive for enterotoxin gene (cpe) by Polymerase chain reaction. The result showed that those foods which tested positive for enterotoxigenic C.perfringens had potential to cause food poisoning. Even those foods which tested negative for the presence of enterotoxigenic C. perfringens could be contaminated from the environment due to poor handling of foods pre- and post processing. Therefore, hygiene should be maintained at all levels of food preparation in order to prevent food borne illness caused by such organism.
Role of Synaptic Structural Plasticity in Impairments of Spatial Learning and Memory Induced by Developmental Lead Exposure in Wistar Rats

Lead (Pb) is found to impair cognitive function. Synaptic structural plasticity is considered to be the physiological basis of synaptic functional plasticity and has been recently found to play important roles in learning and memory. To study the effect of Pb on spatial learning and memory at different developmental stages, and its relationship with alterations of synaptic structural plasticity, postnatal rats were randomly divided into three groups: Control; Pre-weaning Pb (Parents were exposed to 2 mM PbCl2 3 weeks before mating until weaning of pups); Post-weaning Pb (Weaned pups were exposed to 2 mM PbCl2 for 9 weeks). The spatial learning and memory of rats was measured by Morris water maze (MWM) on PND 85–90. Rat pups in Pre-weaning Pb and Post-weaning Pb groups performed significantly worse than those in Control group (p<0.05). However, there was no significant difference in the performance of MWM between the two Pb-exposure groups. Before MWM (PND 84), the number of neurons and synapses significantly decreased in Pre-weaning Pb group, but not in Post-weaning Pb group. After MWM (PND 91), the number of synapses in Pre-weaning Pb group increased significantly, but it was still less than that of Control group (p<0.05); the number of synapses in Post-weaning Pb group was also less than that of Control group (p<0.05), although the number of synapses has no differences between Post-weaning Pb and Control groups before MWM. In both Pre-weaning Pb and Post-weaning Pb groups, synaptic structural parameters such as thickness of postsynaptic density (PSD), length of synaptic active zone and synaptic curvature increased significantly while width of synaptic cleft decreased significantly compared to Control group (p<0.05). Our data demonstrated that both early and late developmental Pb exposure impaired spatial learning and memory as well as synaptic structural plasticity in Wistar rats.
A study of fairness judgments in China , Switzerland and Canada : Do culture , being a student , and gender matter ?

This study compares judgments of the fairness of economic actions among survey populations in Switzerland, and both student and non-student groups in the People’s Republic of China, with the earlier Kahneman, Knetsch and Thaler (1986a) surveys of Canadians. The findings suggest that fairness concerns matter among all of these groups, and the general patterns of what was and was not considered to be fair were similar. However, there were also some significant differences with the influence of fairness being weaker in the two Chinese samples than in the groups from the Western countries, with the influence being weakest in the Chinese student population for the wage related topics. On the whole, almost no significant gender differences were found in any of the new surveys.
Towards wearable sensing-based assessment of fluid intake

Fluid intake is an important information for many health and assisted living applications. At the same time it is inherently difficult to monitor. Existing reliable solutions require augmented drinking containers, which severely limits the applicability of such systems. In this paper we investigate two key components of an unobtrusive, wearable solution that is independent of a particular drinking container or environment.
How the mechanisms of long-term synaptic potentiation and depression serve experience-dependent plasticity in primary visual cortex

Donald Hebb chose visual learning in primary visual cortex (V1) of the rodent to exemplify his theories of how the brain stores information through long-lasting homosynaptic plasticity. Here, we revisit V1 to consider roles for bidirectional ‘Hebbian’ plasticity in the modification of vision through experience. First, we discuss the consequences of monocular deprivation (MD) in the mouse, which have been studied by many laboratories over many years, and the evidence that synaptic depression of excitatory input from the thalamus is a primary contributor to the loss of visual cortical responsiveness to stimuli viewed through the deprived eye. Second, we describe a less studied, but no less interesting form of plasticity in the visual cortex known as stimulus-selective response potentiation (SRP). SRP results in increases in the response of V1 to a visual stimulus through repeated viewing and bears all the hallmarks of perceptual learning. We describe evidence implicating an important role for potentiation of thalamo-cortical synapses in SRP. In addition, we present new data indicating that there are some features of this form of plasticity that cannot be fully accounted for by such feed-forward Hebbian plasticity, suggesting contributions from intra-cortical circuit components.