Miracle-dz/UniFAR-FTUs huggingface dataset:
A Multiwavelength Study of M17: The Spectral Energy Distribution and PAH Emission Morphology of a Massive Star Formation Region

We combine diffuse emission photometry from GLIMPSE and several other Galactic plane surveys covering near-IR through radio wavelengths to synthesize a global spectral energy distribution (SED) for the M17 complex. By balancing the integrated flux in the SED with the total bolometric luminosity of all known O and early B stars in the ionizing cluster, we estimate a distance to M17 of 1.6 kpc. At this distance, the observed total flux in the SED corresponds to a luminosity of 2.4 ± 0.3 × 106 L☉. We find that the SED from the H II region peaks at shorter wavelengths and has a qualitatively different shape than the SED from the photodissociation region (PDR). We find that polycyclic aromatic hydrocarbons (PAHs) are destroyed over a short distance or edge at the boundary of the H II region. We demonstrate that this PAH destruction edge can be located easily using GLIMPSE band-ratio images and confirm this using Spitzer IRS spectra. We investigate the relative roles of extreme ultraviolet (EUV) and X-ray photons in the destruction of PAHs, concluding that X-rays are not an important PAH destruction mechanism in M17 or, by extension, in any other Galactic H II region. Our results support the hypothesis that PAHs are destroyed by EUV photons within H II regions. PAHs dominate the mid-IR emission in the neutral PDR beyond the ionized gas.
Development of a New Tacaribe Arenavirus Infection Model and Its Use to Explore Antiviral Activity of a Novel Aristeromycin Analog

Background A growing number of arenaviruses can cause a devastating viral hemorrhagic fever (VHF) syndrome. They pose a public health threat as emerging viruses and because of their potential use as bioterror agents. All of the highly pathogenic New World arenaviruses (NWA) phylogenetically segregate into clade B and require maximum biosafety containment facilities for their study. Tacaribe virus (TCRV) is a nonpathogenic member of clade B that is closely related to the VHF arenaviruses at the amino acid level. Despite this relatedness, TCRV lacks the ability to antagonize the host interferon (IFN) response, which likely contributes to its inability to cause disease in animals other than newborn mice. Methodology/Principal Findings Here we describe a new mouse model based on TCRV challenge of AG129 IFN-α/β and -γ receptor-deficient mice. Titration of the virus by intraperitoneal (i.p.) challenge of AG129 mice resulted in an LD50 of ∼100 fifty percent cell culture infectious doses. Virus replication was evident in the serum, liver, lung, spleen, and brain 4–8 days after inoculation. MY-24, an aristeromycin derivative active against TCRV in cell culture at 0.9 µM, administered i.p. once daily for 7 days, offered highly significant (P<0.001) protection against mortality in the AG129 mouse TCRV infection model, without appreciably reducing viral burden. In contrast, in a hamster model of arenaviral hemorrhagic fever based on challenge with clade A Pichinde arenavirus, MY-24 did not offer significant protection against mortality. Conclusions/Significance MY-24 is believed to act as an inhibitor of S-adenosyl-L-homocysteine hydrolase, but our findings suggest that it may ameliorate disease by blunting the effects of the host response that play a role in disease pathogenesis. The new AG129 mouse TCRV infection model provides a safe and cost-effective means to conduct early-stage pre-clinical evaluations of candidate antiviral therapies that target clade B arenaviruses.
Supporting Orientation of People with Visual Impairment: Analysis of Large Scale Usage Data

In the field of assistive technology, large scale user studies are hindered by the fact that potential participants are geographically sparse and longitudinal studies are often time consuming. In this contribution, we rely on remote usage data to perform large scale and long duration behavior analysis on users of iMove, a mobile app that supports the orientation of people with visual impairments. Exploratory analysis highlights popular functions, common configuration settings, and usage patterns among iMove users. The study shows stark differences between users accessing the app through VoiceOver and other users, who tend to use the app more scarcely and sporadically.Analysis through clustering of VoiceOver iMove user interactions discovers four distinct user groups: 1) users interested in surrounding points of interest, 2) users keeping the app active for long sessions while in movement, 3) users interacting in short bursts to inquire about current location, and 4) users querying in bursts about surrounding points of interest and addresses. Our analysis provides insights into iMove's user base and can inform decisions for tailoring the app to diverse user groups, developing future improvements of the software, or guiding the design process of similar assistive tools.
Comparison of blood lipids, blood pressures and left ventricular cavity dimension between soccer players and non-athletes

In this study, it was aimed to compare the investigate the effects of regular exercise on blood lipids, blood pressure and left ventricular cavity dimensions function between soccer players and non athletes in football players. This study consisted included a total of 30 subjects, including an experimental group including 18 soccer players footballers who were training on a regular basis at least 2 h a day, 3 days a week, for 5 years and a control group including 12 sedentary individuals with similar age and same gender who were not interested in sports. Total cholesterol (TC), triglyceride (TG) and fasting blood glucose (FBG) levels, systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic diameter (LVSD), and left ventricular diastolic diameter (LVDD) were measured and evaluated in both groups. The measurements revealed that mean systolic blood pressure (SBP) levels of soccer players footballers were significantly lower than control group (p<.05) and that mean left ventricular systolic diameters (LVSD) and left ventricular diastolic diameters (LVDD) of soccer players footballers were significantly higher than control group (p <.05). As a result, long-term effect of regular physical exercises may be responsible for the favorable effects on left ventricular cavity dimensions function.
disuse : A finite element study Prediction of risk of fracture in the tibia due to altered bone mineral density distribution resulting from

The disuse-related bone loss that results from immobilisation following injury shares characteristics with osteoporosis in post-menopausal women and the aged, with decreases in bone mineral density leading to weakening of the bone and increased risk of fracture. The aim of this study was to use the finite element method to: (i) calculate the mechanical response of the tibia under mechanical load and (ii) estimate of the risk of fracture; comparing between two groups, an able-bodied group and spinal cord injury patients group suffering from varying degrees of bone loss. The tibiae of eight male subjects with chronic spinal cord injury and those of four able-bodied age-matched controls were scanned using multi-slice peripheral quantitative computed tomography. Images were used to develop full three-dimensional models of the tibiae in Mimics (Materialise) and exported into Abaqus (Simulia) for calculation of stress distribution and fracture risk in response to specified loading conditions – compression, bending and torsion. The percentage of elements that exceeded a calculated value of the ultimate stress provided an estimate of the risk of fracture for each subject, which differed between spinal cord injury subjects and their controls. The differences in bone mineral density distribution along the tibia in different subjects resulted in different regions of the bone being at high risk of fracture under set loading conditions, illustrating the benefit of creating individual material distribution models. A predictive tool can be developed based on these models, to enable clinicians to estimate the amount of loading that can be safely allowed onto the skeletal frame of individual patients who suffer from extensive musculoskeletal degeneration (including spinal cord injury, multiple sclerosis and the ageing population). The ultimate aim is to reduce fracture occurrence in these vulnerable groups.
Flow Through Collapsible Tubes: Augmented Flow Produced by Resistance at the Outlet

The physical laws describing the character of flow through blood vessels may depart radically from those which have been developed by engineers and physicists for uniform flow through rigid tubes of uniform diameter. These deviations are marked in the case of flow through collapsible tubes, such as blood vessels and valves. At critically high velocities, the flow pattern may be transformed from a quiet, uniform smooth-flowing stream to an interrupted series of jets with the production of audible sound and with marked energy losses. The present study deals primarily with the "paradoxically" increased flow which may take place through collapsible tubes when a resistance is added to the outlet from the system. This marked deviation from the laws for rigid tubes is attributed to the vessel-distending effects of the added resistance, and to the inhibition of the phenomenon of recurrent collapsibility. The present in vitro experiments are used to attempt to explain certain paradoxical findings in flow through the collapsible tube systems of the body.
Livestock keepers' perception of indigenous goat breeds and their contribution to livelihoods in Pakistan.

SUMMARY The objective of this study was to determine the objectives of goat production, related management practices and their role in the live of rural poor through Participatory Rural Appraisal at two experimental sites including Bahawalpur (Site I) and Faisalabad (Site II) in Pakistan. Three villages were randomly selected from each site for appraisals. The data were collected through discussions with the livestock keepers about the goat production systems, contribution to livelihood, role in livelihood, breeding and selection, key constraints and sale of animals. The data were analysed using Chi square test. It was found that contribution of livestock to livelihood was significantly (P 0.05) between sites and between genders with the only exception for poor and all except very poor differences (P<0.001). Modes of spending money and trends were different between sites (P<0.001). The preferred traits were number of kids, feed intake and age at maturity in Teddy goats while milk yield, body size, colour, disease resistance and taste of meat in Beetal goats. Makhi Cheeni strain of Beetal goats is preferred at Site I and Black and White spotted strain of Beetal breed is preferred at Site II. Major constraints identified were problems in production and sales, disease attacks, mortality, scarcity of drinking water, predation, theft, lack of quality breeds, feed and finance. It is suggested that government should extend
Spinal Cord Injury Community Survey: Understanding the Needs of Canadians with SCI.

BACKGROUND There is a lack of literature regarding service needs of people with SCI living in the community. Better assessment of expressed and met and unmet needs would help in the development of effective service delivery. OBJECTIVE From a national SCI Community Survey in Canada, the aim was to identify the most critical service needs of people living in the community at least 1 year post discharge from rehabilitation and the support they received to meet their needs. METHOD Data were collected mainly through a secure Web site and encompassed demographics, personal and household income, an SCI severity measure, and an SCI community needs measure containing information on 13 SCI-related needs. RESULTS A total of 1,549 persons with SCI (traumatic lesion, n = 1,137; nontraumatic lesion, n = 412) across Canada completed the survey. Most critical needs for community integration were expressed by a substantial proportion of survey participants, but significantly more expressed and met needs were reported by persons with a traumatic than a nontraumatic lesion. Personal and environmental characteristics influenced the probability of expressing and meeting needs (eg, severity of injury and household income). Help and support to meet expressed needs were received from government agencies, community organizations, and friends or family. CONCLUSION Better assessment of expressed and met or unmet needs for services remains a challenge but will serve as a tool to optimize service delivery in the community. Environmental barriers to services, particularly the process of getting needs met and associated costs, remain an issue that requires a reconsideration of some aspects of access to services.
Birds of a Feather Flock Together: Experience-Driven Formation of Visual Object Categories in Human Ventral Temporal Cortex

The present functional magnetic resonance imaging study provides direct evidence on visual object-category formation in the human brain. Although brain imaging has demonstrated object-category specific representations in the occipitotemporal cortex, the crucial question of how the brain acquires this knowledge has remained unresolved. We designed a stimulus set consisting of six highly similar bird types that can hardly be distinguished without training. All bird types were morphed with one another to create different exemplars of each category. After visual training, fMRI showed that responses in the right fusiform gyrus were larger for bird types for which a discrete category-boundary was established as compared with not-trained bird types. Importantly, compared with not-trained bird types, right fusiform responses were smaller for visually similar birds to which subjects were exposed during training but for which no category-boundary was learned. These data provide evidence for experience-induced shaping of occipitotemporal responses that are involved in category learning in the human brain.
Anemia and Cerebral Outcomes: Many Questions, Fewer Answers

A number of clinical studies have associated acute anemia with cerebral injury in perioperative patients. Evidence of such injury has been observed near the currently accepted transfusion threshold (hemoglobin [Hb] concentration, 7–8 g/dL), and well above the threshold for cerebral tissue hypoxia (Hb 3–4 g/dL). However, hypoxic and nonhypoxic mechanisms of anemia-induced cerebral injury have not been clearly elucidated. In addition, protective mechanisms which may minimize cerebral injury during acute anemia have not been well defined. Vasodilatory mechanisms, including nitric oxide (NO), may help to maintain cerebral oxygen delivery during anemia as all three NO synthase (NOS) isoforms (neuronal, endothelial, and inducible NOS) have been shown to be up-regulated in different experimental models of acute hemodilutional anemia. Recent experimental evidence has also demonstrated an increase in an important transcription factor, hypoxia inducible factor (HIF)-1&agr;, in the cerebral cortex of anemic rodents at clinically relevant Hb concentrations (Hb 6–7 g/dL). This suggests that cerebral oxygen homeostasis may be in jeopardy during acute anemia. Under hypoxic conditions, cytoplasmic HIF-1&agr; degradation is inhibited, thereby allowing it to accumulate, dimerize, and translocate into the nucleus to promote transcription of a number of hypoxic molecules. Many of these molecules, including erythropoietin, vascular endothelial growth factor, and inducible NOS have also been shown to be up-regulated in the anemic brain. In addition, HIF-1&agr; transcription can be increased by nonhypoxic mediators including cytokines and vascular hormones. Furthermore, NOS-derived NO may also stabilize HIF-1&agr; in the absence of tissue hypoxia. Thus, during anemia, HIF-1&agr; has the potential to regulate cerebral cellular responses under both hypoxic and normoxic conditions. Experimental studies have demonstrated that HIF-1&agr; may have either neuroprotective or neurotoxic capacity depending on the cell type in which it is up-regulated. In the current review, we characterize these cellular processes to promote a clearer understanding of anemia-induced cerebral injury and protection. Potential mechanisms of anemia-induced injury include cerebral emboli, tissue hypoxia, inflammation, reactive oxygen species generation, and excitotoxicity. Potential mechanisms of cerebral protection include NOS/NO-dependent optimization of cerebral oxygen delivery and cytoprotective mechanisms including HIF-1&agr;, erythropoietin, and vascular endothelial growth factor. The overall balance of these activated cellular mechanisms may dictate whether or not their up-regulation leads to cytoprotection or cellular injury during anemia. A clearer understanding of these mechanisms may help us target therapies that will minimize anemia-induced cerebral injury in perioperative patients.
Random, deterministic, and hybrid algorithms for distributed beamforming

Distributed beamforming is a form of cooperation among nodes in a wireless network to efficiently deliver a common message to a distant receiver. The critical requirement to achieve electromagnetic coherence is to synchronize the initial phases of all local oscillators, introducing minimal overhead and complexity. In the paper we introduce random, deterministic and hybrid algorithms, all based on feedback from the common receiver as the driving force, but with different phase update strategies. Our numerical results show that these algorithms achieve faster convergence time than previously proposed approaches.
Capsicum: Practical Capabilities for UNIX

Capsicum is a lightweight operating system capability and sandbox framework planned for inclusion in FreeBSD 9. Capsicum extends, rather than replaces, UNIX APIs, providing new kernel primitives (sandboxed capability mode and capabilities) and a userspace sandbox API. These tools support compartmentalisation of monolithic UNIX applications into logical applications, an increasingly common goal supported poorly by discretionary and mandatory access control. We demonstrate our approach by adapting core FreeBSD utilities and Google's Chromium web browser to use Capsicum primitives, and compare the complexity and robustness of Capsicum with other sandboxing techniques.
Implementation of a Large System-Wide Hepatitis C Virus Screening and Linkage to Care Program for Baby Boomers

Abstract Background We implemented and evaluated a large health system-wide hepatitis C virus (HCV) screening and linkage to care program for persons born between 1945 and 1965 (“baby boomers”). Methods An electronic health record (EHR) clinical decision support (CDS) tool for HCV screening for baby boomers was introduced in August 2015 for patients seen in the outpatient University of California, Los Angeles healthcare system setting. An HCV care coordinator was introduced in January 2016 to facilitate linkage to HCV care. We compared HCV testing in the year prior (August 2014–July 2015) to the year after (August 2015–July 2016) implementation of the CDS tool. Among patients with reactive HCV antibody testing, we compared outcomes related to the care cascade including HCV ribonucleic acid (RNA) testing, HCV RNA positivity, and linkage to HCV specialty care. Results During the study period, 19606 participants were screened for HCV antibody. Hepatitis C virus antibody screening increased 145% (from 5676 patients tested to 13930 tested) after introduction of the CDS intervention. Screening increased across all demographic groups including age, sex, and race/ethnicity, with the greatest increases among those in the older age groups. The addition of an HCV care coordinator increased follow-up HCV RNA testing for HCV antibody positive patients from 83% to 95%. Ninety-four percent of HCV RNA positive patients were linked to care postimplementation. Conclusions Introduction of an EHR CDS tool and care coordination markedly increased the number of baby boomers screened for HCV, rates of follow-up HCV RNA testing, and linkage to specialty HCV care for patients with chronic HCV infection.
Self-Organising Maps in Computer Security

Some argue that biologically inspired algorithms are the future of solving difficult problems in computer science. Others strongly believe that the future lies in the exploration of mathematical foundations of problems at hand. The field of computer security tends to accept the latter view as a more appropriate approach due to its more workable validation and verification possibilities. The lack of rigorous scientific practices prevalent in biologically inspired security research does not aid in presenting bio-inspired security approaches as a viable way of dealing with complex security problems. This chapter introduces a biologically inspired algorithm, called the SelfOrganising Map (SOM), that was developed by Teuvo Kohonen in 1981. Since the algorithm’s inception it has been scrutinised by the scientific community and analysed in more than 4000 research papers, many of which dealt with various computer security issues, from anomaly detection, analysis of executables all the way to wireless network monitoring. In this chapter a review of security related SOM research undertaken in the past is presented and analysed. The algorithm’s biological analogies are detailed and the author’s view on the future possibilities of this successful bio-inspired approach are given. The SOM algorithm’s close relation to a number of vital functions of the human brain and the emergence of multi-core computer architectures are the two main reasons behind our assumption that the future of the SOM algorithm and its variations is promising, notably in the field of computer security.
Factor Analysis Since Spearman : Where Do We Stand ? What Do We Know ?

With advancing age, healthy adults typically exhibit decreases in performance across many different cognitive abilities such as memory, processing speed, spatial ability, and abstract reasoning. However, there are marked individual differences in rates of cognitive decline, with some adults declining steeply and others maintaining high levels of functioning. To move toward a comprehensive understanding of cognitive aging, it is critical to know whether individual differences in longitudinal changes interrelate across different cognitive abilities. We identified 89 effect sizes representing shared variance in longitudinal cognitive change from 22 unique datasets composed of more than 30,000 unique individuals, which we meta-analyzed using a series of multilevel metaregression models. An average of 60% of the variation in cognitive changes was shared across cognitive abilities. Shared variation in changes increased with age, from approximately 45% at age 35 years to approximately 70% at age 85 years. There was a moderate-to-strong correspondence (r .49, congruence coefficient .98) between the extent to which a variable indicated general intelligence and the extent to which change in that variable indicated a general factor of aging-related change. Shared variation in changes did not differ substantially across cognitive ability domain classifications. In a sensitivity analysis based on studies that carefully controlled for dementia, shared variation in longitudinal cognitive changes remained at upward of 60%, and age-related increases in shared variation in cognitive changes continued to be evident. These results together provide strong evidence for a general factor of cognitive aging that strengthens with advancing adult age.