Miracle-dz/UniFAR-FTUs huggingface dataset:
Evolution of organic and inorganic components of aerosol during a Saharan dust episode observed in the French Alps

A Saharan dust event was observed in a rural area in the Maurienne Valley (French Alps) in summer 2000. Detailed data on PM 10 , particle numbers, and aerosol chemistry (ionic species and Elemental Carbon (EC) and Organic Carbon (OC)) are presented. The comparative evolutions of particle numbers and chemistry (calcium, sodium, and sulfate) show that the overall period included two episodes of dust particles with very distinct chemistry, followed by an episode with a large increase of the concentrations of species with an anthropogenic origin. The overall data set does not indicate large interactions between the dust particles and compounds from anthropogenic origin (sulfate, nitrate) or with organic carbon, all of these species showing very low concentrations. Simplistic calculations indicate that these concentrations are consistent with our current knowledge of adsorption processes of gases on mineral dust in a clean air mass.
Modeling three-dimensional velocity-to-position transformation in oculomotor control.

1. A considerable amount of attention has been devoted to understanding the velocity-position transformation that takes place in the control of eye movements in three dimensions. Much of the work has focused on the idea that rotations in three dimensions do not commute and that a "multiplicative quaternion model" of velocity-position integration is necessary to explain eye movements in three dimensions. Our study has indicated that this approach is not consistent with the physiology of the types of signals necessary to rotate the eyes. 2. We developed a three-dimensional dynamical system model for movement of the eye within its surrounding orbital tissue. The main point of the model is that the eye muscles generate torque to rotate the eye. When the eye reaches an orientation such that the restoring torque of the orbital tissue counterbalances the torque applied by the muscles, a unique equilibrium point is reached. The trajectory of the eye to reach equilibrium may follow any path, depending on the starting eye orientation and eye velocity. However, according to Euler's theorem, the equilibrium reached is equivalent to a rotation about a fixed axis through some angle from a primary orientation. This represents the shortest path that the eye could take from the primary orientation in reaching equilibrium. Consequently, it is also the shortest path for returning the eye to the primary orientation. Thus the restoring torque developed by the tissue surrounding the eye was approximated as proportional to the product of this angle and a unit vector along this axis. The relationship between orientation and restoring torque gives a unique torque-orientation relationship. 3. Once the appropriate torque-orientation relationship for eye rotation is established the velocity-position integrator can be modeled as a dynamical system that is a direct extension of the one-dimensional velocity-position integrator. The linear combination of the integrator state and a direct pathway signal is converted to a torque signal that activates the muscles to rotate the eyes. Therefore the output of the integrator is related to a torque signal that positions the eyes. It is not an eye orientation signal. The applied torque signal drives the eye to an equilibrium orientation such that the restoring torque equals the applied torque but in the opposite direction. The eye orientation reached at equilibrium is determined by the unique torque-orientation relation. Because torque signals are vectors, they commute. (ABSTRACT TRUNCATED AT 400 WORDS)
Mining for Structural Anomalies in Graph-based Data

In this paper we present graph-based approaches to mining for anomalies in domains where the anomalies consist of unexpected entity/relationship alterations that closely resemble non-anomalous behavior. We introduce three novel algorithms for the purpose of detecting anomalies in all possible types of graph changes. Each of our algorithms focuses on a specific graph change and uses the minimum description length principle to discover those substructure instances that contain anomalous entities and relationships. Using synthetic and real-world data, we evaluate the effectiveness of each of these algorithms in terms of each of the types of anomalies. Each of these algorithms demonstrates the usefulness of examining a graph-based representation of data for the purposes of detecting fraud.
Perceptual and Conceptual Abilities of Residential School Deaf Children

plane. The research literature pertaining to conceptual organization of deaf children is consistent in showing them to be less mature than matched hearing individuals. Templin (12), Oleron (9), Levine (5), and McKay (6) have agreed in this conclusion. However, in the area of visual perception, studies of deaf children have produced widely divergent results. Since the need for further research in this phase of perception is more observable, this report will deal primarily with visual
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.

BACKGROUND The efficacy of tamoxifen therapy for the treatment of breast cancer varies widely among individuals. Plasma concentrations of the active tamoxifen metabolite endoxifen are associated with the cytochrome P450 (CYP) 2D6 genotype. We examined the effects of concomitant use of selective serotonin reuptake inhibitor antidepressants, which are CYP2D6 enzyme inhibitors commonly prescribed to treat hot flashes in women who take tamoxifen, and genotypes for genes that encode tamoxifen-metabolizing enzymes on plasma concentrations of tamoxifen and its metabolites. METHODS Eighty patients with newly diagnosed with breast cancer who were beginning tamoxifen therapy (20 mg/day orally), 24 of whom were taking CYP2D6 inhibitors, were genotyped for common alleles of the CYP2D6, CYP2C9, CYP3A5, and sulfotransferase (SULT) 1A1 genes. Plasma concentrations of tamoxifen and its metabolites were measured after 1 and 4 months of tamoxifen therapy. Differences in plasma concentrations of tamoxifen and its metabolites between genotype groups were analyzed by the Wilcoxon rank sum test. All statistical tests were two-sided. RESULTS Among all women, plasma endoxifen concentrations after 4 months of tamoxifen therapy were statistically significantly lower in subjects with a CYP2D6 homozygous variant genotype (20.0 nM, 95% confidence interval [CI] = 11.1 to 28.9 nM) or a heterozygous genotype (43.1 nM, 95% CI = 33.3 to 52.9 nM) than in those with a homozygous wild-type genotype (78.0 nM, 95%CI = 65.9 to 90.1 nM) (both P = .003). Among subjects who carried a homozygous wild-type genotype, the mean plasma endoxifen concentration for those who were using CYP2D6 inhibitors was 58% lower than that for those who were not (38.6 nM versus 91.4 nM, difference = -52.8 nM, 95% CI = -86.1 to -19.5 nM, P = .0025). The plasma endoxifen concentration was slightly reduced in women taking venlafaxine, a weak inhibitor of CYP2D6, whereas the plasma endoxifen concentration was reduced substantially in subjects who took paroxetine (a potent inhibitor of CYP2D6). Genetic variations of CYP2C9, CYP3A5, or SULT1A1 had no statistically significant associations with plasma concentrations of tamoxifen or its metabolites. CONCLUSION Interactions between CYP2D6 polymorphisms and coadministered antidepressants and other drugs that are CYP2D6 inhibitors may be associated with altered tamoxifen activity.
Integrity of the cone photoreceptor mosaic in oligocone trichromacy.

PURPOSE Oligocone trichromacy (OT) is an unusual cone dysfunction syndrome characterized by reduced visual acuity, mild photophobia, reduced amplitude of the cone electroretinogram with normal rod responses, normal fundus appearance, and normal or near-normal color vision. It has been proposed that these patients have a reduced number of normal functioning cones (oligocone). This paper has sought to evaluate the integrity of the cone photoreceptor mosaic in four patients previously described as having OT. METHODS Retinal images were obtained from two brothers (13 and 15 years) and two unrelated subjects, one male (47 years) and one female (24 years). High-resolution images of the cone mosaic were obtained using high-speed adaptive optics (AO) fundus cameras. Visible structures were analyzed for density using custom software. Additional retinal images were obtained using spectral domain optical coherence tomography (SD-OCT), and the four layers of the photoreceptor-retinal pigment epithelium complex (ELM, IS/OS, RPE1, RPE2) were evaluated. Cone photoreceptor length and the thickness of intraretinal layers were measured and compared to previously published normative data. RESULTS The adult male subject had infantile onset nystagmus while the three other patients did not. In the adult male patient, a normal appearing cone mosaic was observed. However, the three other subjects had a sparse mosaic of cones remaining at the fovea, with no structure visible outside the central fovea. On SD-OCT, the adult male subject had a very shallow foveal pit, with all major retinal layers being visible, and both inner segment (IS) and outer segment (OS) length were within normal limits. In the other three patients, while all four layers were visible in the central fovea and IS length was within normal limits, the OS length was significantly decreased. Peripherally the IS/OS layer decreased in intensity, and the RPE1 layer was no longer discernable, in keeping with the lack of cone structure observed on AO imaging outside the central fovea. CONCLUSIONS Findings are consistent with the visual deficits being caused by a reduced number of healthy cones in the two brothers and the adult female. In the unrelated adult subject, no structural basis for the disorder was found. These data suggest two distinct groups on the basis of structural imaging. It is proposed that the former group with evidence of a reduction in cone numbers is more in keeping with typical OT, with the latter group representing an OT-like phenotype. These two groups may be difficult to readily discern on the basis of phenotypic features alone, and high-resolution imaging may be an effective way to distinguish between these phenotypes.
Regularity of the Adjoint State for the Instationary Navier-Stokes Equations

In this article, we are considering imbeddings of abstract functions in spaces of functions being continuous in time. A family of functions depending on certain parameters is discussed in detail. In particular, this example shows that such functions do not belong to the space C([0, T ], H). In the second part, we investigate an optimal control problem for the instationary Navier-Stokes equation. We will answer the question, in which sense the initial value problem for the adjoint equation can be solved.
Breast Tissue Stiffness in Compression is Correlated to Histological Diagnosis

Many researchers have proposed imaging the stiffness distribution in breast tissue to enhance diagnosis of disease. They suppose that cancers are much stiffer than the surrounding tissue but to our knowledge no measurements have been made of these properties that accurately characterize them over a wide range of strain. We hypothesize that there is a correlation between elastic modulus in compression and histological diagnosis (e.g. infiltrating ductal carcinoma, normal glandular tissue, etc.). We also hypothesize that the cancer exhibits greater non-linearity; its change in modulus with strain is greater. We present a correlation that allows elastic moduli to be estimated from force displacement curves measured during punch indentation testing. The tissue samples tested were obtained during surgery and were tested immediately after removal from the body. We found that there is a significant difference in the stiffness and the rate of increase in stiffness with strain between cancerous and benign breast tissues. Infiltrating ductal cancer is more than 10 times as stiff as normal fat tissue at 1% strain, and more than 70 times as stiff at 15% strain. Compared to normal glandular tissue, this type of cancer is more than 2.5 times as stiff at 1% strain and nearly 5 times as stiff at 15% strain. Therefore, relative stiffness is a good indicator of histological diagnosis.
Emergency Cerclage: Literature Review

Abstract This article reviews the use and effectiveness of emergency cerclage for women who present with a dilated cervix in the second trimester of pregnancy and seeks to identify predictors of favorable emergency cerclage outcomes. We searched PubMed and the Cochrane Library for the period January 1995 to April 2012 and used the terms “emergency cerclage,” “emergency stitch,” “rescue cerclage,” and “rescue stitch. ” Thirty-four studies in which transvaginal emergency cervical cerclage was performed in women with a dilated cervix were identified and included. Predictors of poor outcome were prolapsed membranes, evidence of intra-amniotic or systemic infection, symptomatic presentation, cervical dilatation greater than 3 cm, or cerclage after 22 weeks. According to observational and limited randomized controlled trials, the cerclage group did significantly better than the bed-rest group in mean randomization-to-delivery interval, preterm delivery before 34 weeks, and compound neonatal morbidity. The current data suggest that emergency cerclage is associated with a longer latency period and, most often, with better pregnancy outcomes when compared with bed rest. Many of the predictors of adverse outcomes appear to be associated with evidence of inflammation or infection. Target Audience: Obstetricians and gynecologists, family physicians Learning Objectives: After completing this CME activity, physicians should be better able to review the use and evaluate the effectiveness of emergency cerclage for women who present with a dilated cervix in the second trimester, to identify predictors of favorable emergency cerclage outcomes, and to compare emergency cerclage versus bed rest.
Reliability of computerized surface electromyography for determining the onset of muscle activity.

The reliability of a computerized analysis system (CAS) for determining muscle burst onset was compared with the subjective assessments of three trained examiners. A sample of 154 randomly selected, full-wave rectified and filtered electromyographic recordings was evaluated using a test-retest paradigm. Percentages of agreement, Pearson product-moment correlations, analyses of variance (ANOVAs), and intraclass correlation coefficients (ICCs) were used to measure the reliability. The between-rater agreement, which included the computerized EMG assessments, was only 23%. Within-rater agreement and Pearson correlation coefficients were perfect for CAS. The trained examiners' within-rater assessments averaged only 51% agreement, but test-retest correlations were high (r = .78 - r = .82). All ICCs were statistically significant, ranged from . 46 to . 60, and tended to be higher when the CAS onset determinations were deleted from the analysis. The ANOVAs revealed that trained examiners were more consistent among each other than when their assessments were compared with CAS assessments of EMG recordings. This finding, however, may be facility-specific in that any generalization to other examiners was limited. In contrast to trained examiners, the CAS was free of variations in judgment, ensured perfect reproducibility of trial assessments, and was highly useful for analyzing multi-channel EMG recordings. Although the CAS ensures perfect reliability, validity determinations require visual inspection of trial data.
Neuromorphic hardware in the loop: Training a deep spiking network on the BrainScaleS wafer-scale system

Emulating spiking neural networks on analog neuromorphic hardware offers several advantages over simulating them on conventional computers, particularly in terms of speed and energy consumption. However, this usually comes at the cost of reduced control over the dynamics of the emulated networks. In this paper, we demonstrate how iterative training of a hardware-emulated network can compensate for anomalies induced by the analog substrate. We first convert a deep neural network trained in software to a spiking network on the BrainScaleS wafer-scale neuromorphic system, thereby enabling an acceleration factor of 10000 compared to the biological time domain. This mapping is followed by the in-the-loop training, where in each training step, the network activity is first recorded in hardware and then used to compute the parameter updates in software via backpropagation. An essential finding is that the parameter updates do not have to be precise, but only need to approximately follow the correct gradient, which simplifies the computation of updates. Using this approach, after only several tens of iterations, the spiking network shows an accuracy close to the ideal software-emulated prototype. The presented techniques show that deep spiking networks emulated on analog neuromorphic devices can attain good computational performance despite the inherent variations of the analog substrate.
Hierarchical Neural Network Generative Models for Movie Dialogues

We consider the task of generative dialogue modeling for movie scripts. To this end, we extend the recently proposed hierarchical recurrent encoder decoder neural network and demonstrate that this model is competitive with state-of-the-art neural language models and backoff n-gram models. We show that its performance can be improved considerably by bootstrapping the learning from a larger questionanswer pair corpus and from pretrained word embeddings.
Comparison of EKF and PEKF in a SLAM context

This paper introduces an implementation of the polynomial extended Kalman filter (PEKF) to solve the simultaneous localization and Map building (SLAM) problem. The proposed solution is a filtering algorithm which is a polynomial transformation of state evolution and measurement equations. The performances of the algorithm have been evaluated through two simulation runs. The first ones underline consistency improvement in comparison with the standard extended Kalman Filter. The other simulation results show the PEKF efficiency when the values of measurement noises are high. At the end, experiments with Victoria Park data are presented too.
Adaptive Fuzzy Output Tracking Control of MIMO Nonlinear Uncertain Systems

In this paper, the adaptive fuzzy tracking control problem is discussed for a class of uncertain multiple-input-multiple-output (MIMO) nonlinear systems with the block-triangular structure. The fuzzy logic systems are used to approximate the unknown nonlinear functions. By using the backstepping technique, the adaptive fuzzy tracking control design scheme is developed, which has minimal learning parameterizations. The adaptive fuzzy tracking controllers guarantee that the outputs of systems converge to a small neighborhood of the reference signals and all the signals in the closed-loop system are semiglobally uniformly ultimately bounded. Two examples are used to show the effectiveness of the approach
An Analysis of Preliminary and Post-Discussion Priority Scores for Grant Applications Peer Reviewed by the Center for Scientific Review at the NIH

There has been the impression amongst many observers that discussion of a grant application has little practical impact on the final priority scores. Rather the final score is largely dictated by the range of preliminary scores given by the assigned reviewers. The implication is that the preliminary and final scores are the same and the discussion has little impact. The purpose of this examination of the peer review process at the National Institutes of Health is to describe the relationship between preliminary priority scores of the assigned reviewers and the final priority score given by the scientific review group. This study also describes the practical importance of any differences in priority scores. Priority scores for a sample of standard (R01) research grant applications were used in this assessment. The results indicate that the preliminary meeting evaluation is positively correlated with the final meeting outcome but that they are on average significantly different. The results demonstrate that discussion at the meeting has an important practical impact on over 13% of the applications.
Gelotophobia: life satisfaction and happiness across cultures

The fear of being laughed at (gelotophobia) was examined in its relations to concepts from positive psychology in Austria, China, and Switzerland. It was related to satisfaction with life and Peterson et al.’s (2005) three orientations to happiness; the life of pleasure (hedonism), life of engagement (related to flow-experiences), and life of meaning (eudaimonia). Participants (N = 744) completed self-report measures of gelotophobia, satisfaction with life, and orientations to happiness. The results revealed that gelotophobia could be found in all three countries. The participants exceeded cut-off points indicating gelotophobia in Austria (5.80%), China (7.31%), and Switzerland (7.23%). The fear of being laughed at was negatively related to life-satisfaction in all three countries. Gelotophobes described themselves with lower overall estimations of their lives. Gelotophobia was negatively correlated with life engagement (i.e., flow experiences). In China, gelotophobia was also related to a lower life of pleasure and life of meaning. Overall, the results show that gelotophobes do not pursue any of the three orientations to happiness. Interventions from positive psychology (e.g., enhancing satisfaction with life, strengthening the routes to happiness) are discussed as possible treatments of gelotophobia.
Amino acid availability and age affect the leucine stimulation of protein synthesis and eIF4F formation in muscle.

We have previously shown that a physiological increase in plasma leucine for 60 and 120 min increases translation initiation factor activation in muscle of neonatal pigs. Although muscle protein synthesis is increased by leucine at 60 min, it is not maintained at 120 min, perhaps because of the decrease in plasma amino acids (AA). In the present study, 7- and 26-day-old pigs were fasted overnight and infused with leucine (0 or 400 micromol.kg(-1). h(-1)) for 120 min to raise leucine within the postprandial range. The leucine was infused in the presence or absence of a replacement AA mixture (without leucine) to maintain baseline plasma AA levels. AA administration prevented the leucine-induced reduction in plasma AA in both age groups. At 7 days, leucine infusion alone increased eukaryotic initiation factor (eIF) 4E binding protein-1 (4E-BP1) phosphorylation, decreased inactive 4E-BP1.eIF4E complex abundance, and increased active eIF4G.eIF4E complex formation in skeletal muscle; leucine infusion with replacement AA also stimulated these, as well as 70-kDa ribosomal protein S6 kinase, ribosomal protein S6, and eIF4G phosphorylation. At 26 days, leucine infusion alone increased 4E-BP1 phosphorylation and decreased the inactive 4E-BP1.eIF4E complex only; leucine with AA also stimulated these, as well as 70-kDa ribosomal protein S6 kinase and ribosomal protein S6 phosphorylation. Muscle protein synthesis was increased in 7-day-old (+60%) and 26-day-old (+40%) pigs infused with leucine and replacement AA but not with leucine alone. Thus the ability of leucine to stimulate eIF4F formation and protein synthesis in skeletal muscle is dependent on AA availability and age.