Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient, low-complexity image coding with a set-partitioning embedded block coder

We propose an embedded, block-based, image wavelet transform coding algorithm of low complexity. It uses a recursive set-partitioning procedure to sort subsets of wavelet coefficients by maximum magnitude with respect to thresholds that are integer powers of two. It exploits two fundamental characteristics of an image transform-the well-defined hierarchical structure, and energy clustering in frequency and in space. The two partition strategies allow for versatile and efficient coding of several image transform structures, including dyadic, blocks inside subbands, wavelet packets, and discrete cosine transform (DCT). We describe the use of this coding algorithm in several implementations, including reversible (lossless) coding and its adaptation for color images, and show extensive comparisons with other state-of-the-art coders, such as set partitioning in hierarchical trees (SPIHT) and JPEG2000. We conclude that this algorithm, in addition to being very flexible, retains all the desirable features of these algorithms and is highly competitive to them in compression efficiency.
TGF-β-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen

Transforming growth factor-β (TGF-β), a key modulator of endothelial cell apoptosis, must be activated from the latent form (LTGF-β) to induce biological responses. In the present study, we report activation of TGF-β by functional and physical co-operation of the mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) and the urokinase-type plasminogen activator receptor (CD87). We show that endothelial cells express CD222 and CD87 in a membrane complex and demonstrate that the association of these two receptors is essential for the release of active TGF-β in the transduced mouse fibroblast used as model cells. By contrast, smooth-muscle cells, which express CD222 and CD87 at similar density to endothelial cells but not in complexed form, do not activate TGF-β. We also have found that mini-plasminogen is a high-affinity ligand for CD222 and is essential for the activation of TGF-β by the CD87-CD222 complex to induce apoptosis in endothelial cells. This specific mechanism of TGF-β-mediated apoptosis in endothelial cells is thus a potential novel target to be considered for treatment of pathological vascular disorders (e.g. tumor angiogenesis).
Illuminating micro geometry based on precomputed visibility

Many researchers have been arguing that geometry, bump maps, and BRDFs present a hierarchy of detail that should be exploited for efficient rendering purposes. In practice however, this is often not possible due to inconsistencies in the illumination for these different levels of detail. For example, while bump map rendering often only considers direct illumination and no shadows, geometry-based rendering and BRDFs will mostly also respect shadowing effects, and in many cases even indirect illumination caused by scattered light. In this paper, we present an approach for overcoming these inconsistencies. We introduce an inexpensive method for consistently illuminating height fields and bump maps, as well as simulating BRDFs based on precomputed visibility information. With this information we can achieve a consistent illumination across the levels of detail. The method we propose offers significant performance benefits over existing algorithms for computing the light scattering in height fields and for computing a sampled BRDF representation using a virtual gonioreflectometer. The performance can be further improved by utilizing graphics hardware, which then also allows for interactive display. Finally, our method also approximates the changes in illumination when the height field, bump map, or BRDF is applied to a surface with a different curvature.
Shock veins and brown olivine in Martian meteorites: Implications for their shock pressure–temperature histories

Shergottite Martian meteorites are known to contain brown‐colored olivine (brown olivine), which is considered to form during a shock event on Mars. In order to constrain the formation conditions of brown olivine, four shergottites with brown olivine and four shergottites without brown olivine are analyzed in this study. Based on our observations, brown olivine is often accompanied by thin (<10 μm) melt veins indicating local temperature increase (1750–1870 K). Even in shergottites without brown olivine, olivine around shock melt veins/pockets is partly darkened and shows similar features to those of brown olivine. These observations support that brown olivine is formed under conditions similar to those around shock melt veins/pockets. Components of shock melt veins (vesicles, quench crystals, etc.) and the absence of high‐pressure phases in shergottites with brown olivine indicate that they have high postshock temperature (>1200–1170 K). Such high postshock temperature may indicate that shergottites with brown olivine experienced high pressure (around 55 GPa), while shergottites without brown olivine experienced lower shock pressure (>20–35 GPa). Therefore, brown olivine may be a good indicator for strong shock events (peak shock pressure: ~55 GPa; postshock temperature: >1200–1170 K) and such shock events could be induced by small but rapid projectiles onto Mars.
PhysarumSpreader: A New Bio-Inspired Methodology for Identifying Influential Spreaders in Complex Networks

Identifying influential spreaders in networks, which contributes to optimizing the use of available resources and efficient spreading of information, is of great theoretical significance and practical value. A random-walk-based algorithm LeaderRank has been shown as an effective and efficient method in recognizing leaders in social network, which even outperforms the well-known PageRank method. As LeaderRank is initially developed for binary directed networks, further extensions should be studied in weighted networks. In this paper, a generalized algorithm PhysarumSpreader is proposed by combining LeaderRank with a positive feedback mechanism inspired from an amoeboid organism called Physarum Polycephalum. By taking edge weights into consideration and adding the positive feedback mechanism, PhysarumSpreader is applicable in both directed and undirected networks with weights. By taking two real networks for examples, the effectiveness of the proposed method is demonstrated by comparing with other standard centrality measures.
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment

Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b+Gr1+ myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models. High G-CSF production has been associated with a poor prognosis in cancer patients. Here we show that activation of the RAS/MEK/ERK pathway regulates G-CSF expression through the Ets transcription factor. Several growth factors induced G-CSF expression by a MEK-dependent mechanism. Inhibition of G-CSF release with a MEK inhibitor markedly reduced G-CSF production in vitro and synergized with anti-VEGF antibodies to reduce CD11b+Ly6G+ neutrophil mobilization and tumor growth and led to increased survival in animal models of cancer, including a genetically engineered mouse model of pancreatic adenocarcinoma. Analysis of biopsies from pancreatic cancer patients revealed increased phospho-MEK, G-CSF, and Ets expression and enhanced neutrophil recruitment compared with normal pancreata. These results provide insights into G-CSF regulation and on the mechanism of action of MEK inhibitors and point to unique anticancer strategies.
Game-Theoretic Security for Two-Party Protocols

Asharov, Canetti, and Hazay (Eurocrypt 2011) studied how game-theoretic concepts can be used to capture the cryptographic properties of correctness, privacy, and fairness in two-party protocols for failstop adversaries. In this work, we further study the characterization of the cryptographic properties of specific two-party protocols, oblivious transfer (OT) and commitment, in terms of game theory. Specifically, for each protocol, OT and commitment, we define a two-party game between rational sender and receiver together with their utility functions. Then, we prove that a given protocol satisfies cryptographic properties if and only if the strategy of following the protocol is in a Nash equilibrium. Compared to the previous work of Asharov et al., our characterization has several advantages: The game is played by multiple rational parties; All the cryptographic properties of OT/commitment are characterized by a single game; Security for malicious adversaries is considered; Utility functions are specified in general forms based on the preferences of the parties; A solution concept employed is a plain Nash equilibrium.
Investigating Continuous Space Language Models for Machine Translation Quality Estimation

We present novel features designed with a deep neural network for Machine Translation (MT) Quality Estimation (QE). The features are learned with a Continuous Space Language Model to estimate the probabilities of the source and target segments. These new features, along with standard MT system-independent features, are benchmarked on a series of datasets with various quality labels, including postediting effort, human translation edit rate, post-editing time and METEOR. Results show significant improvements in prediction over the baseline, as well as over systems trained on state of the art feature sets for all datasets. More notably, the addition of the newly proposed features improves over the best QE systems in WMT12 and WMT14 by a significant margin.
A virtual mirror interface using real-time robust face tracking

We describe a virtual mirror interface which can react to people using robust, real-time face tracking. Our display can directly combine a user's face with various graphical effects, performed only on the face region in the image. We have demonstrated our system in crowded environments with open and moving backgrounds. Robust performance is achieved using multi-modal integration, combining stereo, color and grey-scale pattern matching modules into a single real-time system. Stereo processing is used to isolate the figure of a user from other objects and people in the background. Skin-hue classification identifies and tracks likely body parts within the foreground region. Face pattern detection discriminates and localizes the face within the tracked body parts. We show an initial application of the mirror where the user sees his or her face distorted into various comic poses. Qualitatively, users of the system felt the display "knew" where their face was, and provided entertaining imagery. We discuss the failure modes of the individual components, and quantitatively analyze the face localization performance of the complete system with thousands of users in recent trials.
The Modulation of the Quasi‐Two‐Day Wave on Total Electron Content as Revealed by BeiDou GEO and Meteor Radar Observations Over Central China

The ground‐based total electron content (TEC) observations from BeiDou Geostationary Orbit (GEO) satellites provide more accurate temporal ionospheric variations nearly at the fixed ionospheric pierce points as compared with the non‐GEO TEC. BeiDou GEO TEC measurements during 2016, along with the horizontal wind observations from a collocated meteor radar, are utilized to quantitatively study the ionospheric response to the quasi‐two‐day wave (QTDW) in the neutral atmosphere at Meng Cheng (116.6°E, 33.3°N) over central China. The QTDW peaks during July with amplitudes of ~25–30 m/s for both zonal and meridional winds. It is suggested that the nonlinear interactions between the QTDW and tides and their influences on TEC are insignificant for this QTDW event. Nevertheless, the diurnal tide decreases by ~40–60% during the QTDW episode, which is most likely related to the change of background wind induced by the QTDW. Correspondingly, the 24 h oscillations in TEC decrease by ~18%. In addition, the wind perturbations of the QTDW can also possibly modulate the midlatitude electric dynamo and result in a quasi‐two‐day oscillation (QTDO) of ~1.2 total electron content unit (TECU), about ~10% of the background TEC. Our analysis also shows that the background TEC decreases by ~1 TECU (~8%) when the QTDW reaches maximum amplitude. This is probably related to the thermospheric composition changes (e.g., O and N2) induced by the QTDW dissipation.
Bending properties of a macroalga: Adaptation of Peirce's cantilever test for in situ measurements of Laminaria digitata (Laminariaceae).

• Premise of the study: The mechanical properties of a plant are key variables governing the interaction between the plant and its environment. Thus, measuring variables such as the flexural rigidity (bending) of a plant element is necessary to understand and predict the plant-flow interaction. However, plant elements such as macrophyte blades can be relatively thin and flexible, thus difficult to characterize. Different adaptations of the classical 3-point bending tests can also affect the interpretation of the flexural rigidity of an element. A simple, robust, method is newly applied to a biomaterial and validated here as an alternative to measure flexural rigidity of thin, flexible plant elements. • Methods: Based on a bending test procedure developed for the textile industry, an apparatus for in-situ measurements was developed and compared with other normalized methods, then used in a field test on the blade of a marine macroalga (Laminaria digitata) to assess its suitability to measure the bending modulus of a biomaterial. • Key results: Results of the presented method on selected surrogate materials agree with a normalized cantilever method (ISO 9073-7:1998) and 3-point bending test (ISO 178:2010). Values determined for the bending moduli for blades of L. digitaria were in the typical range for algal material. The range of validity of the method is discussed. • Conclusion: By validating this method with existing norms, this study suggests a better approach to measure bending properties of different biomaterials in the field compared with more traditional bending tests and opens new possibilities.
Early Germination, Growth and Establishment of Khaya senegalensis (DESR.) A. Juss in Middle-Belt Zone of Nigeria

A study was carried out to investigate the early growth and establishment of Khaya senegalensis in three different locations (Markurdi, Benue State, Lafia, Nasarawa state and Kwali, Abuja) within the middle belt zone of Nigeria in October 2014 with the aim to mass raising mahogany at economic scale. The study was carried out at the Department of Forestry, Wildlife and Ecotourism Nursery, Nasarawa State University Keffi, Shabu- Lafia Campus. The seeds were separately broadcasted on three different nursery beds and watered effectively. The parameter assessed include Plant height, Leaf count, Leave area and Collar girth. Data was analyzed using Analysis of variance and significant mean differences were separated at p>0.05. The results of parameter assessed on the basis of locations shows that seedlings from Makurdi had the highest mean height of 5.33±2.96cm at 14 weeks after transplanting, closely followed by seedling from Kwali with mean height of 5.33±2.43cm while seedling from Lafia had the least mean height of 5.29±2.46cm. The result of leave count revealed that seedling from Lafia had the highest leave count of 5.28±2.84 followed by Kwali with 5.25±3.00 while leave count of seedlings from Makurdi had the least leave count of 5.18±3.0. The result of growth variables revealed that, Khaya senegalensis saplings intercropped with cassava at Agroforestry plantation Plot had attained 2.415±0.45m average height, 11.12±3.5cm basal girth, 3.95±1.43cm dbh, leaf count of 151.37±18.84 within a period of 36months of planting on the field. The ANOVA result shows that there was significant difference in the leave count, leave length, collar girth and plant height from the three locations at p>0.05, result of correlation analysis revealed that there was a significant correlation between leaf count and plant height (0.78**), collar girth and leaf count (0.67**). While the result of the regression analysis on the effects of growth variables on plant height had coefficient of R 2 = 0.67, meaning that the assessed growth variables had about 67.4% effects on plant height of Khaya senegalensis seeds collected from different locations. The study reveals that seeds from different source demonstrated different growth performance, as it was observed that seeds obtained from Lafia performed better than the other two locations and as a result recommended for mass raising of Khaya senegalens within the middle-belt zone of Nigeria.
5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory Hypersensitivity

H2S functions as a neuromodulator and exerts anti-inflammatory activities. Recent data indicate that irritable bowel syndrome (IBS) is linked to inflammation of the gastrointestinal tract. In this study, we have investigated the role of a novel H2S-releasing derivative of mesalamine (5-amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester, ATB-429) in modulating nociception to colorectal distension (CRD), a model that mimics some features of IBS, in healthy and postcolitic rats. Four graded (0.4-1.6 ml of water) CRDs were produced in conscious rats, and colorectal sensitivity and pain were assessed by measuring the abdominal withdrawal response and spinal c-Fos expression. In healthy rats, ATB-429 dose dependently (25, 50, or 100 mg/kg) attenuated CRD-induced hypersensitivity and significantly inhibited CRD-induced overexpression of spinal c-FOS mRNA, whereas mesalamine had no effect. ATB-429-induced antinociception was reversed by glibenclamide, a ATP-sensitive K+ (KATP) channel inhibitor. The antinociceptive effect of ATB-429 was maintained in a rodent model of postinflammatory hypersensitivity (4 weeks after colitis induction). At a dose of 100 mg/kg, ATB-429 reversed the allodynic response caused by CRD in postcolitic rats. Colonic cyclooxygenase-2 and interkeukin-1β mRNA and spinal c-FOS mRNA expression were significantly down-regulated by ATB-429, but not by mesalamine. ATB-429, but not mesalamine, increased blood concentrations of H2S in both healthy and postcolitic rats. Taken together, these data suggest that ATB-429 inhibits hypersensitivity induced by CRD in both healthy and postcolitic, allodynic rats by a KATP channel-mediated mechanism. This study provides evidence that H2S-releasing drugs might have beneficial effects in the treatment of painful intestinal disorders.
Swarm Intelligence in Animal Groups: When Can a Collective Out-Perform an Expert?

An important potential advantage of group-living that has been mostly neglected by life scientists is that individuals in animal groups may cope more effectively with unfamiliar situations. Social interaction can provide a solution to a cognitive problem that is not available to single individuals via two potential mechanisms: (i) individuals can aggregate information, thus augmenting their ‘collective cognition’, or (ii) interaction with conspecifics can allow individuals to follow specific ‘leaders’, those experts with information particularly relevant to the decision at hand. However, a-priori, theory-based expectations about which of these decision rules should be preferred are lacking. Using a set of simple models, we present theoretical conditions (involving group size, and diversity of individual information) under which groups should aggregate information, or follow an expert, when faced with a binary choice. We found that, in single-shot decisions, experts are almost always more accurate than the collective across a range of conditions. However, for repeated decisions – where individuals are able to consider the success of previous decision outcomes – the collective's aggregated information is almost always superior. The results improve our understanding of how social animals may process information and make decisions when accuracy is a key component of individual fitness, and provide a solid theoretical framework for future experimental tests where group size, diversity of individual information, and the repeatability of decisions can be measured and manipulated.
Learning Individual Behavior in an Educational Game: A Data-Driven Approach

In recent years, open-ended interactive educational tools such as games have been gained popularity due to their ability to make learning more enjoyable and engaging. Modeling and predicting individual behavior in such interactive environments is crucial to better understand the learning process and improve the tools in the future. A model-based approach is a standard way to learn student behavior in highly-structured systems such as intelligent tutors. However, dening such a model relies on expert domain knowledge. The same approach is often extremely dicult in educational games because open-ended nature of these systems creates an enormous space of actions. To ease this burden, we propose a data-driven approach to learn individual behavior given a user’s interaction history. This model does not heavily rely on expert domain knowledge. We use our framework to predict player movements in two educational puzzle games, demonstrating that our behavior model performs signicantly better than a baseline on both games. This indicates that our framework can generalize without requiring extensive expert knowledge specic to each domain. Finally, we show that the learned model can give new insights into understanding player behavior.
Transmigration of Neural Stem Cells across the Blood Brain Barrier Induced by Glioma Cells

Transit of human neural stem cells, ReNcell CX, through the blood brain barrier (BBB) was evaluated in an in vitro model of BBB and in nude mice. The BBB model was based on rat brain microvascular endothelial cells (RBMECs) cultured on Millicell inserts bathed from the basolateral side with conditioned media (CM) from astrocytes or glioma C6 cells. Glioma C6 CM induced a significant transendothelial migration of ReNcells CX in comparison to astrocyte CM. The presence in glioma C6 CM of high amounts of HGF, VEGF, zonulin and PGE2, together with the low abundance of EGF, promoted ReNcells CX transmigration. In contrast cytokines IFN-α, TNF-α, IL-12p70, IL-1β, IL-6, IL-8 and IL-10, as well as metalloproteinases -2 and -9 were present in equal amounts in glioma C6 and astrocyte CMs. ReNcells expressed the tight junction proteins occludin and claudins 1, 3 and 4, and the cell adhesion molecule CRTAM, while RBMECs expressed occludin, claudins 1 and 5 and CRTAM. Competing CRTAM mediated adhesion with soluble CRTAM, inhibited ReNcells CX transmigration, and at the sites of transmigration, the expression of occludin and claudin-5 diminished in RBMECs. In nude mice we found that ReNcells CX injected into systemic circulation passed the BBB and reached intracranial gliomas, which overexpressed HGF, VEGF and zonulin/prehaptoglobin 2.