Miracle-dz/UniFAR-FTUs huggingface dataset:
Event-related cortical processing in neuropathic pain under long-term spinal cord stimulation.

BACKGROUND Several mechanisms were suggested in the past to explain the beneficial effect of spinal cord stimulation (SCS) in patients suffering from neuropathic pain. Little is known about potential supraspinal mechanisms. OBJECTIVE In this study cortical signaling of patients with neuropathic pain and successful long-term treatment with SCS was analyzed. STUDY DESIGN Observational study. SETTING University hospital, neurosurgical department, outpatient clinic for movement disorders and pain, institute for cognitive and clinical neuroscience. METHODS Nine patients with neuropathic pain of a lower extremity with a lasting response to chronic SCS were included. Cortical activity was analyzed using event-related potentials of the electroencephalogram after non-painful and painful stimulation. Each patient was tested under the effect of long-term SCS and 24 hours after cessation of SCS. Cortical areas involved in the peaks of evoked potentials were localized using a source localization method based on a fixed dipole model. RESULTS Detection threshold and intensity of non-painful stimulation did not differ significantly on both sides. Pain threshold was significantly lower on the neuropathic side under the effect of SCS (P = 0.03). Bilateral pain thresholds were significantly lower (P = 0.03 healthy side, P = 0.003 neuropathic side) in 5 patients with increased pain after cessation of SCS. Under the effect of SCS cortical negativities (N1, N2, N3) and positivities (P1) demonstrated bilaterally comparable amplitudes. After cessation of SCS, decreased threshold for peripheral stimulation resulted in lowered negativities on both sides. The positivity P1 was differentially regulated and was reduced more contralateral to the unaffected side. N2 was localized at the sensory representation of the leg within the homunculus. The main vector of P1 was localized within the cingular cortex (CC) and moved more anteriorly under the effect of SCS. LIMITATIONS The exact time span that SCS continues to have an effect is not known. However, due to patient discomfort discontinuation of SCS therapy was not prolonged over a 24 hour period. Further limitations were the low number of patients who agreed to discontinue SCS therapy for research purposes. CONCLUSIONS Long-term SCS for treatment of neuropathic pain influenced both pain thresholds and cortical signalling. Source localization of P1 suggests involvement of regions involved in cognitive/associative processing of pain.
Direct Measurement of Diffusion in Olfactory Cilia Using a Modified FRAP Approach

The diffusion coefficient of fluorescein in detached cilia of Xenopus laevis olfactory receptor neurons was measured using spatially-resolved FRAP, where the dye along half of the ciliary length was photobleached and its spatiotemporal fluorescence redistribution recorded. Fitting a one-dimensional numerical simulation of diffusion and photobleaching for 35 cilia resulted in a mean value of the diffusion coefficient and thus a reduction by a factor of compared to free diffusion in aqueous solution.
Building a Village through Data: A Research-Practice Partnership to Improve Youth Outcomes

There is growing recognition that the traditional research paradigm fails to address the needs of school practitioners. As such, more collaborative and participatory approaches are being encouraged. Yet few articles examine the structures, processes, and dynamics of research–practice partnerships. To address this gap, this essay analyzes a research alliance between a university and a full-service community school district focused on family engagement. It identifies strategies that facilitate working relations between university researchers, school practitioners, and community stakeholders; describes the complexities in mobilizing research for action; and demonstrates how linking data can bridge institutional silos and strengthen relations among youth-serving organizations. Through an in-depth, single case examination, this article seeks to demonstrate the potential of research–practice partnerships as a community development strategy whereby individuals who share common aims can generate useful knowledge and bring about positive change in the lives of young people.
Large Scale Dynamics of Precipitation Fronts in the Tropical Atmosphere: A Novel Relaxation Limit

A simplifled set of equations is derived systematically below for the interaction of large scale ∞ow flelds and precipitation in the tropical atmosphere. These equations, the Tropical Climate Model, have the form of a shallow water equation and an equation for moisture coupled through a strongly nonlinear source term. This source term, the precipitation, is of relaxation type in one region of state space for the temperature and moisture, and vanishes identically elsewhere in the state space of these variables. In addition, the equations are coupled nonlinearly to the equations for barotropic incompressible ∞ow. Several mathematical features of this system are developed below including energy principles for solutions and their flrst derivatives independent of relaxation time. With these estimates, the formal inflnitely fast relaxation limit converges to a novel hyperbolic free boundary problem for the motion of precipitation fronts from a large scale dynamical perspective. Elementary exact solutions of the limiting dynamics involving precipitation fronts are developed below and include three families of waves: fast drying fronts as well as slow and fast moistening fronts. The last two families of waves violate Lax's Shock Inequalities; nevertheless, numerical experiments presented below conflrm their robust realizability with realistic flnite relaxation times. From the viewpoint of tropical atmospheric dynamics, the theory developed here provides a new perspective on the fashion in which the prominent large scale regions of moisture in the tropics associated with deep convection can move and interact with large scale dynamics in the quasi-equilibrium approximation.
On the stabilization of input delayed oscillators

The problem of globally asymptotically stabilizing by bounded feedback an oscillator with an arbitrary delay in the input is solved. A first solution is deduced from a general result on the global stabilization of null controllable linear systems with delay in the input through bounded control laws with a distributed term. Then it is shown through a Lyapunov analysis that the stabilization can be achieved as well when the distributed terms are neglected. It turns out that this result is intimately related to the issue of the output feedback stabilization of oscillators.
Penicillin Kills Chlamydia following the Fusion of Bacteria with Lysosomes and Prevents Genital Inflammatory Lesions in C. muridarum-Infected Mice

The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate bodies (RBs) replicate within a specialized intracellular compartment termed an ‘inclusion’. Alternative persistent intra-cellular forms can be induced in culture by diverse stimuli such as IFNγ or adenosine/EHNA. They do not grow or divide but revive upon withdrawal of the stimulus and are implicated in several widespread human diseases through ill-defined in vivo mechanisms. β-lactam antibiotics have also been claimed to induce persistence in vitro. The present report shows that upon penicillin G (pG) treatment, inclusions grow as fast as those in infected control cells. After removal of pG, Chlamydia do not revert to RBs. These effects are independent of host cell type, serovar, biovar and species of Chlamydia. Time-course experiments demonstrated that only RBs were susceptible to pG. pG-treated bacteria lost their control over host cell apoptotic pathways and no longer expressed pre-16S rRNA, in contrast to persistent bacteria induced with adenosine/EHNA. Confocal and live-video microscopy showed that bacteria within the inclusion fused with lysosomal compartments in pG-treated cells. That leads to recruitment of cathepsin D as early as 3 h post pG treatment, an event preceding bacterial death by several hours. These data demonstrate that pG treatment of cultured cells infected with Chlamydia results in the degradation of the bacteria. In addition we show that pG is significantly more efficient than doxycycline at preventing genital inflammatory lesions in C. muridarum-C57Bl/6 infected mice. These in vivo results support the physiological relevance of our findings and their potential therapeutic applications.
The Expectancy Account of Deception in Negotiations

The Expectancy Account of Deception in Negotiations Elizabeth Wiley Who lies in negotiations—and when and why? While research has considered many factors, an important and understudied determinant is people’s expectancies about others. I argue that negotiators’ expectations about other people can help predict their own deceptive behavior. Chapter I explores how projection and pessimism shape deceptive behavior. Studies 1a-1d investigated negotiators’ expectancies and found evidence of projection and of rampant pessimism; negotiators consistently overestimated the percentage of other people who shared their own beliefs and the percentage of people who thought deception was appropriate in negotiations. Study 2 found that expectancies about others’ ethical standards predicted the degree to which negotiators were misleading or dishonest in negotiations. Study 3 manipulated expectancies and found that a higher perceived prevalence of gamers led to more misleading or dishonest behavior. Negotiators’ decisions to engage in deception were heavily influenced by an exaggerated pessimism about others’ ethical standards. In supplementary analyses, Chapter I also briefly addresses how expectancies about a specific counterpart’s level of deception shape deceptive behavior. Finally, Chapter II investigates how stereotypes shape deceptive behavior in negotiations, using the stereotype content model, which suggests that social groups are judged on two primary dimensions of warmth and competence. Study 1 provided evidence that deceptive negotiators are perceived to possess less warmth and greater competence than truthful negotiators. Study 2 showed that people from cold competent groups are perceived as more deceptive than people from warm incompetent groups. Study 3 tested actual behavior and demonstrated that manipulating the social category membership of a counterpart affected deception in a negotiation situation. Expectancies play a critical and understudied role in influencing a negotiator’s decision to be deceptive.
The effect of exerting adequate persistence in collision avoidance protocols

Many medium access control (MAC) protocols based on a collision-avoidance handshake between the sender and the receiver have been proposed for wireless networks. To date, however, the analysis of these protocols has assumed non-persistent strategies in sending control packets for collision avoidance The persistent strategies discussed In the past for CSMA and CSMA/CD provide performance improvements over non-persistent access only at small traffic loads. We present and analyze a limited persistence approach to the transmission of collision-avoidance control packets. With limited persistence, a node senses the channel before sending collision-avoidance control packets. If the channel is sensed busy, the node persists sensing for an amount of time proportional to the transmission time of a control packet, The node can transmit its control packet if the channel is idle within its persistence waiting time and the channel is known to be available for transmissions; otherwise, the node backs off for a random amount of time and tries sending its control packet at the end of that time. We analyze the effect of limited persistence in source-initiated and receive-initiated collision avoidance protocols by comparing their throughput with and without persistence; the analysis shows that limited persistence makes collision-avoidance protocols more efficient.
Pengaruh Model Pembelajaran Kooperatif Terhadap Peningkatan Mutu Hasil Belajar Siswa

The philosophy of cooperative learning model of Group Investigation is constructivism, which in the learning process is not transferring knowledge from teacher to students, but the students themselves who actively find something and build their own knowledge, not a mechanical process to collect facts. Students are responsible for the learning outcomes. Students make the reasoning of what they learn by means of finding meaning, comparing it with what is already known, and resolving the inequality between what is already known and what is needed in the new experience.
PENGARUH DISIPLIN KERJA DAN KOMUNIKASI ORGANISASI TERHADAP KEPUASAN KERJA DAN KINERJA KARYAWAN (Studi pada Karyawan Divisi Marketing PT. Victory International Futures Kota Malang)

The research aimed at (1) knowing and analyzing the influence of work discipline toward work satisfaction (2) knowing and analyzing the influence of work discipline toward employee performance (3) knowing and analyzing the influence of organizational communication toward work satisfaction (4) knowing and analyzing the influence of organizational communication toward employee performance (5) knowing and analyzing the influence of work satisfaction toward employee performance. The population in the research is employees of marketing division at PT. Victory International Futures of 67 persons and taken all as the samples. Inferential statistic technique used is path analysis. From the inferential analysis, it is concluded that (1) there is significant influence of work discipline toward work satisfaction (2) there is significant influence of organizational communication toward work satisfaction (3) there is significant influence of organizational communication toward work satisfaction (4) there is significant influence organizational communication toward employee performance (5) there is significant influence of work satisfaction toward employee performance (6) data diversity that can be explained by the model of 0.910 or with other word, information in data is 91.0% can be explained by the model. Kеywords: work discipline, organizational communication, work satisfaction, employee performance. АBSTRАK Penelitian ini bertujuan untuk (1) Mengetahui dan menganalisis pengaruh Disiplin Kerja Terhadap Kepuasan Kerja, (2) Mengetahui dan menganalisis pengaruh Disiplin Kerja Terhadap Kinerja Karyawan, (3) Mengetahui dan menganalisis pengaruh Komunikasi Organisasi Terhadap Kepuasan Kerja, (4) Mengetahui dan menganalisis pengaruh Komunikasi Organisasi Terhadap Kinerja Karyawan, (5) Mengetahui dan menganalisis Kepuasan Kerja Terhadap Kinerja Karyawan. Populasi dalam penelitian ini adalah karyawan divisi marketing PT.Victory Internaional Futures yang berjumlah 67 orang karyawan dan diambil semua sebagai anggota sampel. Teknik statistik inferensial yang digunakan adalah analisis jalur ( path analysis ). Dari hasil analisis inferensial, disimpulkan bahwa: (1) Terdapat pengaruh signifikan disiplin kerja terhadap Kepuasan Kerja, (2) Terdapat pengaruh signifikan Komunikasi Organsiasi terhadap Kepuasan kerja, (3) Terdapat pengaruh signifikan Komunikasi Organsiasi terhadap Kepuasan kerja, (4) Terdapat pengaruh signifikan Komunikasi Organisasi terhadap Kinerja Karyawan, (5) Terdapat pengaruh signifikan Kepuasan Kerja terhadap Kinerja Karyawan, (6) Keragaman data yang dapat dijelaskan oleh model tersebut adalah sebesar 0.910 atau dengan kata lain informasi yang terkandung dalam data adalah sebesar 91.0% dapat dijelaskan oleh model tersebut Kаtа Kunci: Disiplin Kerja, Komunikasi Organisasi, Kepuasan Kerja, Kinerja Karyawan
Input-output linearization with simultaneous decoupling by restricted state feedback

The input-output (i/o) linearization with simultaneous decoupling problem of nonsquare nonlinear systems via restricted state feedback is investigated. The problem is treated on the basis of a new algebraic approach, whose main feature is that it reduces the determination of the admissible state feedback control laws to the solution of an algebraic and a first order partial differential systems of equations.Verifiable necessary and sufficient conditions, of algebraic nature, for the solvability of the aforementioned problem, which rely on the solvability of these systems equations, are established. Moreover, an explicit expression for a special admissible restricted state feedback controller is analytically derived.
Relationship Understanding Between Emotional Stability, Self-Disclosure and Social Adjustment

Abstract This paper discusses a survey, carried out by the authors, of 211 employees’ employed in public and private manufacturing organizations in North India to determine if emotional stability acts as a mediator between self-disclosure and social adjustment. Capitalization theory has been used as theoretical framework to examine the proposed relationships. Results indicate that high self-disclosure has positive association with social adjustment. Results also suggest that emotional stability partially mediates self-disclosure and social adjustment relationship. Implications for future research include further examination through additional mediators and other dimensions of self-disclosure from capitalization theory in understudied non-U.S. cultures like India.
Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins

Clostridium botulinum neurotoxins (BoNTs) are the most poisonous naturally occurring protein toxins known to mankind and are the causative agents of the severe and potentially life-threatening disease botulism. They are also known for their application as cosmetics and as unique bio-pharmaceuticals to treat an increasing number of neurological and non-neurological disorders. Currently, the potency of biologically active BoNT for therapeutic use is mainly monitored by the murine LD50-assay, an ethically disputable test causing suffering and death of a considerable number of mice. The aim of this study was to establish an in vitro assay as an alternative to the widely used in vivo mouse bioassay. We report a novel BoNT detection assay using mouse embryonic stem cell-derived neurons (mESN) cultured on multi-electrode arrays (MEAs). After 21 days in culture, the mESN formed a neuronal network showing spontaneous bursting activity based on functional synapses and express the necessary target proteins for BoNTs. Treating cultures for 6 h with 16.6 pM of BoNT serotype A and incubation with 1.66 pM BoNT/A or 33 Units/ml of Botox® for 24 h lead to a significant reduction of both spontaneous network bursts and average spike rate. This data suggests that mESN cultured on MEAs pose a novel, biologically relevant model that can be used to detect and quantify functional BoNT effects, thus accelerating BoNT research while decreasing animal use.
Economic impact analysis of reduced irrigated acreage in four river basins in Colorado

Colorado’s water is an important natural resource that contributes to the state’s economic, cultural and social well-being (Pritchett, et al., 2005). However, this resource is of limited supply and has many competing uses. Although agriculture is still the dominant water use, rapid changes are occurring, and the impacts to Colorado’s agricultural communities are a key concern. In the next twenty-five years, Colorado’s population is expected to exceed 7 million people and an additional 632,000 acre-feet of water will be needed in cities to support their growth. An increasing consensus in the western water community is that new demands must be met primarily through the reallocation of existing supplies (Committee on Western Water Management, 1992). Because agriculture is the marginal-valued user of water supplies, the majority of this new water demand will be supplied through rural-tourban water transfers, with an estimated 400,000 irrigated agricultural acres “drying up” as these transfers occur (Pritchett, et al., 2005). Rural-to-urban water transfers create contentious, emotionally charged discussions that often center on the health of rural economies whose irrigated agricultural base is reduced with each transfer. The difference between the net value of water used for agriculture and municipalities’ willingness-to-pay for water is substantial, so much so that both the buyers and sellers of water stand to gain from out-of-basin water transfers. However, water is a resource with productive capacity, and transferring productive capacity affects more than just the buyer and seller—third parties such as local governments and businesses are affected as well (Pritchett, Frasier, and Schuck, 2003). For example, temporary or permanent income losses may occur to factors of production in sectors with backward or forward linkages to irrigated agriculture. If depressed economic conditions persist, factors of production of agriculture, agricultural supplying activities, and agricultural processing activities can be idled for long periods of time, leading to real efficiency losses. State and regional planning bodies, researchers, and the public are very concerned about the adequacy of available water supplies to sustain Colorado’s population and economic growth. Clearly, it is important to quantify and describe the economic impact of a reduction in irrigated agriculture, to disaggregate the impact among different industries in the region and among households, and to determine how government revenues might shrink. This information will be valuable to many water stakeholders
Safe screening tests for LASSO based on firmly non-expansiveness

This paper focusses on safe screening techniques for the LASSO problem. We derive a new sphere test, coined RFNE, exploiting the firmly non-expansiveness of projection operators. Our test generalizes some methods of the literature but, unlike the latter, exploits approximated primal-dual solutions of the LASSO problem while remaining safe and effective. Our simulation results show that the proposed RFNE test outperforms the best methodology of the state of the art, namely the GAP test derived by Fercoq et al.
Interactive learning of human activities using active video composition

In order to recognize human activities, the system is required to learn properties (i.e. structures) of the activities from training samples. However, existing supervised learning approaches lack interactiveness, solely relying on biased training examples provided by the user. Such approaches are limited especially for real-world scenarios where the amount of training videos is not sufficient. In this paper, we present the novel concept of active video composition learning, a new interactive activity learning paradigm designed to overcome the limitations of the previous paradigm. In contrast to previous passive learning systems relying on user-provided training videos, our approach learns human activities by actively interacting with the human teacher. The idea is to make the system generate composed videos with the activity structure it is most uncertain of and ask the human to provide activity labels for such video queries. In addition, a methodology to semantically represent the system's activity learning status is designed, making the system to interactively inform the human teacher its status and benefit from such interaction. The experimental results confirm that our approach interactively estimates the decision boundaries in the activity structure space, and does it more reliably even when very few real training videos are provided.