Miracle-dz/UniFAR-FTUs huggingface dataset:
Evolution and resolution of long-term cardiac memory.

BACKGROUND Cardiac memory (CM) refers to T-wave changes induced by ventricular pacing or arrhythmia that accumulate in magnitude and duration with repeated episodes of abnormal activation. We report herein the kinetics of long-term CM and its association with the ventricular action potential. METHODS AND RESULTS Dogs were paced from the ventricles at rates of 110 to 120 bpm for approximately 3 weeks. CM characterized by gradual sinus rhythm T vector rotation toward the paced QRS vector evolved in all dogs regardless of pacing site (left ventricular [LV] anterior apex or base, posterior LV, or right ventricular free wall). Cardiac hemodynamics and myocardial flow (microsphere studies) were unaltered by the pacing. Recovery time for the memory T wave to return to control increased with duration of the previous pacing. The protein synthesis inhibitor cycloheximide markedly (P<.05) and reproducibly attenuated evolution of CM. When pacing was performed from the atrium, CM did not occur. Standard microelectrode techniques were used to study action potential from the LV free wall of control and CM dogs. CM was associated with increased action potential duration in epicardial and endocardial but not midmyocardial cells, significantly altering the transmyocardial gradient for repolarization. CONCLUSIONS CM is a dynamic process for which the final T vector is predicted by the paced QRS vector and which is associated with significant changes in epicardial and endocardial but not midmyocardial cell action potential duration, such that the transmural gradient of repolarization is altered. It is unaccompanied by evidence of altered hemodynamics or flow, requires a change in pathway of activation, and appears to require new protein synthesis.
Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats

Phasic firing of dopamine (DA) neurons in the ventral tegmental area (VTA) and substantia nigra (SN) is likely to be crucial for reward processing that guides learning. One of the key structures implicated in the regulation of this DA burst firing is the pedunculopontine tegmental nucleus (PPTg), which projects to both the VTA and SN. Different literatures suggest that the PPTg serves as a sensory‐gating area for DA cells or it regulates voluntary movement. This study recorded PPTg single‐unit activity as rats perform a spatial navigation task to examine the potential for both reward and movement contributions. PPTg cells showed significant changes in firing relative to reward acquisition, the velocity of movement across the maze and turning behaviors of the rats. Reward, but not movement, correlates were impacted by changes in context, and neither correlate type was affected by reward manipulations (e.g. changing the expected location of a reward). This suggests that the PPTg conjunctively codes both reward and behavioral information, and that the reward information is processed in a context‐dependent manner. The distinct anatomical distribution of reward and movement cells emphasizes different models of synaptic control by PPTg of DA burst firing in the VTA and SN. Relevant to both VTA and SN learning systems, however, PPTg appears to serve as a sensory gating mechanism to facilitate reinforcement learning, while at the same time provides reinforcement‐based guidance of ongoing goal‐directed behaviors.
Utilization and Outcomes of Laparoscopic Versus Open Paraesophageal Hernia Repair

The optimal operative approach for repair of diaphragmatic hernia remains debated. The aim of this study was to examine the utilization of laparoscopy and compare the outcomes of laparoscopic versus open paraesophageal hernia repair performed at academic centers. Data was obtained from the University HealthSystem Consortium database on 2726 patients who underwent a laparoscopic (n = 2069) or open (n = 657) paraesophageal hernia repair between 2007 and 2010. The data were reviewed for demographics, length of stay, 30-day readmission, morbidity, in-hospital mortality, and costs. For elective procedures, utilization of laparoscopic repair was 81 per cent and was associated with a shorter hospital stay (3.7 vs 8.3 days, P < 0.01), less requirement for intensive care unit care (13% vs 35%, P < 0.01), and lower overall complications (2.7% vs 8.4%, P < 0.01), 30-day readmissions (1.4% vs 3.4%, P < 0.01) and costs ($15,227 vs $24,263, P < 0.01). The in-hospital mortality was 0.4 per cent for laparoscopic repair versus 0.0 per cent for open repair. In patients presenting with obstruction or gangrene, utilization of laparoscopic repair was 57 per cent and was similarly associated with improved outcomes compared with open repair. Within the context of academic centers, the current practice of paraesophageal hernia repair is mostly laparoscopy. Compared with open repair, laparoscopic repair was associated with superior perioperative outcomes even in cases presenting with obstruction or gangrene.
Sparse Overcomplete Denoising: Aggregation Versus Global Optimization

Denoising is often addressed via sparse coding with respect to an overcomplete dictionary. There are two main approaches when the dictionary is composed of translates of an orthonormal basis. The first, traditionally employed by techniques such as wavelet cycle spinning, separately seeks sparsity w.r. t. each translate of the orthonormal basis, solving multiple partial optimizations and obtaining a collection of sparse approximations of the noise-free image, which are aggregated together to obtain a final estimate. The second approach, recently employed by convolutional sparse representations, instead seeks sparsity over the entire dictionary via a global optimization. It is tempting to view the former approach as providing a suboptimal solution of the latter. In this letter, we analyze whether global sparsity is a desirable property, and under what conditions the global optimization provides a better solution to the denoising problem. In particular, our experimental analysis shows that the two approaches attain comparable performance in case of natural images and global optimization outperforms the simpler aggregation of partial estimates only when the image admits an extremely sparse representation. We explain this phenomenon by separately studying the bias and variance of these solutions, and by noting that the variance of the global solution increases very rapidly as the original signal becomes less and less sparse.
Various Blood Glucose Parameters that Indicate Hyperglycemia after Intravenous Thrombolysis in Acute Ischemic Stroke Could Predict Worse Outcome

Background Hyperglycemia is common after stroke, and it is well known to worsen its outcome. However, it is important to consider that blood glucose (BG) levels can undergo dynamic changes during the acute stage of ischemic stroke. We sought to investigate the clinical significance of various glucose parameters within first 24 hours in acute ischemic stroke (AIS). The study focused on hyperacute stage patients who underwent IVT and investigated which parameters of glucose demonstrated to be helpful for predicting outcome. Methods This was a retrospective study of consecutive patients with AIS at a single stroke center. Patients were consecutively enrolled if they were treated with IV-tPA within 3 hours of symptom onset. BG was measured immediately upon arrival in ER, after IVT and every 6–8 hours during the first 24 hours after IVT. The various parameters of BG were the following: BG before IVT, BG after IVT, mean BG (mBG), maximal BG (max BG), standard deviation of BG (sdBG), and standard deviation of mean BG (sdmBG). Results 207 patients (127 men and 80 women) were included in this study. Seventy seven of 207 patients had favorable outcomes at 3 months. High BG after IVT, mBG and max BG were independently associated with mRS>2 at 3 months (adjusted by age, NIHSS, and atrial fibrillation). Several parameters of BG were also independently associated with early mortality within 3 months (BG after IVT, mBG, and max BG). BG after IVT and mBG over 180 mg/dL were independently associated with early mortality within 3 months. Conclusion Serial measurements of BG might be a better predictor of clinical outcome in patients with AIS treated with IVT than single BG measurements before IVT. Therefore, these results suggest that variable parameters of BG could be important for the prediction of clinical outcome in AIS treated with IVT.
GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly

The identification of genomic rearrangements, particularly in cancers, with high sensitivity and specificity using massively parallel sequencing remains a major challenge. Here, we describe the Genome Rearrangement IDentification Software Suite (GRIDSS), a high-speed structural variant (SV) caller that performs efficient genome-wide break-end assembly prior to variant calling using a novel positional de Bruijn graph assembler. By combining assembly, split read and read pair evidence using a probabilistic scoring, GRIDSS achieves high sensitivity and specificity on simulated, cell line and patient tumour data, recently winning SV sub-challenge #5 of the ICGC-TCGA DREAM Somatic Mutation Calling Challenge. On human cell line data, GRIDSS halves the false discovery rate compared to other recent methods. GRIDSS identifies non-template sequence insertions, micro-homologies and large imperfect homologies, and supports multi-sample analysis. GRIDSS is freely available at https://github.com/PapenfussLab/gridss.
A 5-Gbps 1.7 pJ/bit ditherless CDR with optimal phase interval detection

Dithering in bang-bang controlled CDRs poses conflicting requirements on the phase adjustment resolution as one tries to maximize the tracking bandwidth and minimize jitter. A novel phase interval detector that looks for a phase interval enclosing the desired lock point is shown to find the optimal phase that minimizes the timing error without dithering. A digitally-controlled, phase-interpolating DLL-based CDR fabricated in 65nm CMOS demonstrates that it can achieve low jitter of 41-mUIp-p with a coarse phase adjustment step of 0.11-UI, while dissipating only 8.4mW at 5Gbps. In addition, a digitally-controlled in-situ measurement circuit that can characterize the CDR's jitter tolerance is presented.
In vivo imaging of palisades of Vogt in dry eye versus normal subjects using en-face spectral-domain optical coherence tomography

Purpose To evaluate a possible clinical application of spectral-domain optical coherence tomography (SD-OCT) using en-face module for the imaging of the corneoscleral limbus in normal subjects and dry eye patients. Patients and methods Seventy-six subjects were included in this study. Seventy eyes of 35 consecutive patients with dry eye disease and 82 eyes of 41 healthy control subjects were investigated. All subjects were examined with the Avanti RTVue® anterior segment OCT. En-face OCT images of the corneoscleral limbus were acquired in four quadrants (inferior, superior, nasal and temporal) and then were analyzed semi-quantitatively according to whether or not palisades of Vogt (POV) were visible. En-face OCT images were then compared to in vivo confocal microscopy (IVCM) in eleven eyes of 7 healthy and dry eye patients. Results En-face SD-OCT showed POV as a radially oriented network, located in superficial corneoscleral limbus, with a good correlation with IVCM features. It provided an easy and reproducible identification of POV without any special preparation or any direct contact, with a grading scale from 0 (no visualization) to 3 (high visualization). The POV were found predominantly in superior (P<0.001) and inferior (P<0.001) quadrants when compared to the nasal and temporal quadrants for all subjects examined. The visibility score decreased with age (P<0.001) and was lower in dry eye patients (P<0.01). In addition, the score decreased in accordance with the severity of dry eye disease (P<0.001). Conclusion En-face SD-OCT is a non-contact imaging technique that can be used to evaluate the POV, thus providing valuable information about differences in the limbal anatomy of dry eye patients as compared to healthy patients.
A Prospective, Holistic, Multicenter Approach to Tracking and Understanding Bloodstream Infections in Pediatric Hematology-Oncology Patients

OBJECTIVE To assess the burden of bloodstream infections (BSIs) among pediatric hematology-oncology (PHO) inpatients, to propose a comprehensive, all-BSI tracking approach, and to discuss how such an approach helps better inform within-center and across-center differences in CLABSI rate DESIGN Prospective cohort study SETTING US multicenter, quality-improvement, BSI prevention network PARTICIPANTS PHO centers across the United States who agreed to follow a standardized central-line–maintenance care bundle and track all BSI events and central-line days every month. METHODS Infections were categorized as CLABSI (stratified by mucosal barrier injury–related, laboratory-confirmed BSI [MBI-LCBI] versus non–MBI-LCBI) and secondary BSI, using National Healthcare Safety Network (NHSN) definitions. Single positive blood cultures (SPBCs) with NHSN defined common commensals were also tracked. RESULTS Between 2013 and 2015, 34 PHO centers reported 1,110 BSIs. Among them, 708 (63.8%) were CLABSIs, 170 (15.3%) were secondary BSIs, and 232 (20.9%) were SPBCs. Most SPBCs (75%) occurred in patients with profound neutropenia; 22% of SPBCs were viridans group streptococci. Among the CLABSIs, 51% were MBI-LCBI. Excluding SPBCs, CLABSI rates were higher (88% vs 77%) and secondary BSI rates were lower (12% vs 23%) after the NHSN updated the definition of secondary BSI (P<.001). Preliminary analyses showed across-center differences in CLABSI versus secondary BSI and between SPBC and CLABSI versus non-CLABSI rates. CONCLUSIONS Tracking all BSIs, not just CLABSIs in PHO patients, is a patient-centered, clinically relevant approach that could help better assess across-center and within-center differences in infection rates, including CLABSI. This approach enables informed decision making by healthcare providers, payors, and the public. Infect Control Hosp Epidemiol 2017;38:690–696
A PAC analysis of a Bayesian estimator

Bayesian analysis of generalisation can place a prior distribution on the hypotheses and estimate the volume of this space that is consistent with the training data. The larger this volume the greater the confidence in the classifier obtained. The key feature of such estimators is that they provide a posteriori estimates of generalisation based on properties of the hypothesis and the training data. This contrasts with a ‘classical’ PAC analysis which provides only a priori (worst case) bounds. Following results in [26] showing that Datasensitive analysis of generalisation in the PAC sense is possible, the paper uses the techniques to give the first PAC style analysis of a Bayesian inspired estimator of generalisation. The estimator concerned is the size of a ball which can be placed in the consistent region of parameter space. The ball gives a lower bound on the volume of parameter space consistent with the training set. The larger the ball the better the bound on the generalisation obtained. In all cases the bounds are of good generalisation with high confidence, hence bounding the tail of the distribution of generalisation errors that might occur. The resulting bounds are independent of the complexity of the function class though they depend linearly on the dimensionality of the parameter space. Permission to make digitnl/hnrd copies ofnll or part ofthis mntcl-inl fol personal or clw.mnm use is gr:u’ted withaut I kc pwvidcd 11~1 lhc oop~s are 1101 made or distrihutrd For profit or comnwx~l advnm~gr. the copy right notice, the title of the puhlwxtion and its dnie appear. and n&t: is given that copyright is hy psmksion of~hr . Ac’M. lnc To copy othmvisc to republish. IO post on servers or to rrdistrilwtr 10 lists. rquires ~pcxilic pemission m&or fee COLT 97 Nashville. Tennesee. USA Copyright 1997 ACM O-89791~891~6197i7. %3.50 Robert C. Williamson Dept of Engineering Australian National University Canberra 0200 Australia Bob.WilliamsonQanu. edu.au
On the overlay of envelopes in four dimensions

We show that the complexity of the overlay of two envelopes of arrangements of n semi-algebraic surfaces or surface patches of constant description complexity in four dimensions is O(n4-1/⌈s/2⌉+ε), for any ε > 0, where s is a constant related to the maximal degree of the surfaces. This is the first non-trivial (sub-quartic) bound for this problem, and for s = 1, 2 it almost matches the near-cubic lower bound. We discuss several applications of this result, including (i) an improved bound for the complexity of the region enclosed between two envelopes in four dimensions, (ii) an improved bound for the complexity of the space of all hyperplane transversals of a collection of simply-shaped convex sets in 4-space, (iii) an improved bound for the complexity of the space of all line transversals of a similar collection of sets in 3-space, and (iv) improved bounds for the complexity of the union of certain families of objects in four dimensions. The analysis technique we introduce is quite general, and has already proved useful in unrelated contexts.
Slow and Discontinuous Conduction Conspire in Brugada Syndrome: A Right Ventricular Mapping and Stimulation Study

Background—Brugada syndrome (BrS) is associated with lethal arrhythmias, which are linked to specific ST-segment changes (type-1 BrS-ECG) and the right ventricle (RV). The pathophysiological basis of the arrhythmias and type-1 BrS-ECG is unresolved. We studied the electrophysiological characteristics of the RV endocardium in BrS. Methods and Results—RV endocardial electroanatomical mapping and stimulation studies were performed in controls (n=12) and BrS patients with a type-1 (BrS-1, n=10) or type-2 BrS-ECG (BrS-2, n=12) during the studies. BrS-1 patients had prominent impairment of RV endocardial impulse propagation when compared with controls, as represented by: (1) prolonged activation-duration during sinus rhythm (86±4 versus 65±3 ms), (2) increased electrogram fractionation (1.36±0.04 versus 1.15±0.01 deflections per electrogram), (3) longer electrogram duration (83±3 versus 63±2 ms), (4) activation delays on premature stimulation (longitudinal: 160±26 versus 86±9 ms; transversal: 112±5 versus 58±6 ms), and (5) abnormal transversal conduction velocity restitution (42±8 versus 18±2 ms increase in delay at shortest coupling intervals). Wider and more fractionated electrograms were also found in BrS-2 patients. Repolarization was not different between groups. Conclusions—BrS-1 and BrS-2 patients are characterized by wide and fractionated electrograms at the RV endocardium. BrS-1 patients display additional conduction slowing during sinus rhythm and premature stimulation along with abnormal transversal conduction velocity restitution. These patients may thus exhibit a substrate for slow and discontinuous conduction caused by abnormal active membrane processes and electric coupling. Our findings support the emerging notion that BrS is not solely attributable to abnormal electrophysiological properties but requires the conspiring effects of conduction slowing and tissue discontinuities.
Moisture Transport and Absorption in Multilayer Protective Clothing Fabrics

The distribution of moisture in state-of-the-art firefighter protective clothing was analyzed on a sweating torso. After one hour of sweating, only 35 % of moisture evaporated from the layers, but after another hour of drying out, only about 10 % of the supplied moisture remained in the clothing. Over 75 % of this moisture accumulated in the innermost three layers of the clothing system consisting of five and six layers, respectively. The interaction of the moisture transport properties of the different layers proved to be very important for the distribution of moisture. In particular, the neighboring layer of the underwear turned out to be dominant for the moisture distribution. Depending on its hygroscopic properties, it could even act as a water barrier.
Efficient SimRank-based Similarity Join Over Large Graphs

Graphs have been widely used to model complex data in many real-world applications. Answering vertex join queries over large graphs is meaningful and interesting, which can benefit friend recommendation in social networks and link prediction, etc. In this paper, we adopt "SimRank" to evaluate the similarity of two vertices in a large graph because of its generality. Note that "SimRank" is purely structure dependent and it does not rely on the domain knowledge. Specifically, we define a SimRank-based join (SRJ) query to find all the vertex pairs satisfying the threshold in a data graph G . In order to reduce the search space, we propose an estimated shortest-path distance based upper bound for SimRank scores to prune unpromising vertex pairs. In the verification, we propose a novel index, called h-go cover, to efficiently compute the SimRank score of a single vertex pair. Given a graph G , we only materialize the SimRank scores of a small proportion of vertex pairs (called h-go covers), based on which, the SimRank score of any vertex pair can be computed easily. In order to handle large graphs, we extend our technique to the partition-based framework. Thorough theoretical analysis and extensive experiments over both real and synthetic datasets confirm the efficiency and effectiveness of our solution.
Transition of HIV-infected youths from paediatric to adult care, a Swedish single-centre experience

Abstract Background Transition of HIV-infected adolescents from paediatric care to adult care is vulnerable and entails a risk of treatment failure. Therefore, a Transitional Outpatient Clinic for HIV-infected adolescents and young adults was started in 2008. The aims were to describe the transition process and treatment results in a Swedish cohort of adolescents with HIV. Materials and methods A cross-sectional study of the adolescent and young adults with HIV at the clinic was performed in October 2013 and a 2-year follow-up at the end of 2015. Results The 34 patients in care in October 2013 were a median of 19 years, 50% were female. Thirty-one out of 34 (91%) were perinatally infected. In 2013, 88% were on antiretroviral treatment (ART), for a median duration of 9 years, 74% were on a protease inhibitor-based regimen. Twenty-nine patients were followed-up at the end of 2015. Twenty-three were transferred to the Infectious Disease Clinic and the median age for transition was 19 years. At the end of 2015, 90% were treated with ART and 61% had an integrase inhibitor-based treatment. Of those treated with ART for more than 6 months, 90% (2013) and 96% (2015) had a viral load < 50 HIV RNA copies/mL, despite resistance problems and complicating social factors. These figures were higher than reported in other studies and similar to the treatment results in the adult HIV population in Sweden. Conclusions The present study showed that it is possible to achieve good treatment results in adolescents with HIV.
An unsteady multifluid flow model: Application to sandwich injection molding process

The sandwich molding process consists of injecting sequentially a skin and core polymers. The thermomechanical model describing the flow of the two polymers into the mold cavity is based on the lubrication approximations. A transport equation characterizes the displacement of the interface between the two fluids. An experimental study has been performed in order to test the influence of processing parameters (viscosities, flow rates, etc.) on the interface location. Numerical simulations are in agreement with measurements.