Miracle-dz/UniFAR-FTUs huggingface dataset:
Clustering of behavioural risk factors for non-communicable diseases (NCDs) among rural-based adolescents in south-west Nigeria

Abstract Background: Non-communicable diseases (NCDs) have become the leading cause of deaths globally and the key associated risk factors – alcohol abuse, physical inactivity, cigarette smoking and poor dietary patterns – are often initiated in adolescence. Co-existence of these risk factors further increase the risk for NCDs. Yet, very little is known about the pattern of co-occurrence of behavioural risk factors for NCDs among Nigerian adolescents, especially those in rural areas. This study aimed to assess the prevalence and determinants of clustering patterns of behavioural risk factors for NCDs among in-school adolescents in rural areas of Osun State, Nigeria. Methods: This cross-sectional study involved 476 adolescents recruited through multi-stage sampling across Osun State. Data were collected through a facilitated self-administered questionnaire with questions adapted from the Global School-Based Health Survey (GSHS) instrument. Data were analysed using Stata, with binary logistic regression used to identify determinants. Results: The mean age of the respondents was 14.7±2.0 years and females constituted 50.2% of them. Among the respondents, 36.1% had reported consuming alcoholic drinks but no one met the criteria for harmful alcohol use, while 8.8% had ever smoked cigarettes and only one respondent (0.2%) was a current smoker. The prevalence of poor diet (89.5%) and physical inactivity (85.9%) was, however, high. Poor diet and physical inactivity co-occurred in 369 (77.5%) respondents, while one respondent (0.2%) had three risk factors (poor diet, physical inactivity and current smoking). Being in a senior secondary school class (odds ratio, OR=1.6; 95% confidence interval, C.I.=1.04–2.39) and living with parents (OR=0.53; 0.33–0.90) were significantly associated with clustering of NCD behavioural risk factors. Conclusion: The prevalence of clustering of modifiable risk factors for NCDs was high among rural-based in-school adolescents in south-west Nigeria, and there is a need to mount effective interventions. Findings from this study have the potential to inform effective school-based NCD control programmes.
Development of a Microsphere-Based System to Facilitate Real-Time Insulin Monitoring

Background: The speed of insulin absorption after subcutaneous delivery is highly variable. Incorrect assumptions about insulin pharmacokinetics compromise effective glycemic regulation. Our ultimate goal is to develop a system to monitor insulin levels in vivo continuously, allowing pharmacokinetic parameters to be calculated in real time. We hypothesize that a bead-based detection system can be run on a flow-through microfluidic platform to measure insulin in subcutaneous fluid sampled via microdialysis. As a first step in development, we focused on microsphere-based measurement of insulin. Methods: Polystyrene microspheres coated with an anti-insulin monoclonal antibody were exposed to insulin-containing solutions, and after addition of a fluorescently labeled anti-insulin monoclonal antibody with a distinct epitope, bead-associated fluorescence was detected by fluorescence microscopy in 96-well plates or in a flow-through, microfluidic platform. Results: The bead detection system in plates had a linear range in buffer for regular human insulin (RHI), insulin lispro, and insulin aspart of 15-1115 µIU/ml, 14-976 µIU/ml, and 25-836 µIU/ml, respectively. Measurement on plasma samples demonstrated proportionality between basal and peak insulin levels similar to the laboratory reference method. Preliminary results in a polydimethylsiloxane-based, flow-through, microfluidic platform showed a strong signal at peak insulin levels. Conclusions: We have developed a microsphere-based system to rapidly measure levels of insulin and insulin analogs. We have further demonstrated proof of concept that this bead detection system can be implemented in a lab-on-a-chip format, which will be further developed and combined with microdialysis for real-time monitoring of insulin in vivo.
Temperature‐driven selection on metabolic traits increases the strength of an algal–grazer interaction in naturally warmed streams

Trophic interactions are important determinants of the structure and functioning of ecosystems. Because the metabolism and consumption rates of ectotherms increase sharply with temperature, there are major concerns that global warming will increase the strength of trophic interactions, destabilizing food webs, and altering ecosystem structure and function. We used geothermally warmed streams that span an 11°C temperature gradient to investigate the interplay between temperature‐driven selection on traits related to metabolism and resource acquisition, and the interaction strength between the keystone gastropod grazer, Radix balthica, and a common algal resource. Populations from a warm stream (~28°C) had higher maximal metabolic rates and optimal temperatures than their counterparts from a cold stream (~17°C). We found that metabolic rates of the population originating from the warmer stream were higher across all measurement temperatures. A reciprocal transplant experiment demonstrated that the interaction strengths between the grazer and its algal resource were highest for both populations when transplanted into the warm stream. In line with the thermal dependence of respiration, interaction strengths involving grazers from the warm stream were always higher than those with grazers from the cold stream. These results imply that increases in metabolism and resource consumption mediated by the direct, thermodynamic effects of higher temperatures on physiological rates are not mitigated by metabolic compensation in the long term, and suggest that warming could increase the strength of algal–grazer interactions with likely knock‐on effects for the biodiversity and productivity of aquatic ecosystems.
Parental guided self‐help family based treatment for adolescents with anorexia nervosa: A feasibility study

OBJECTIVE Family-based treatment (FBT) is an evidence-based treatment for adolescent anorexia nervosa (AN), but many families cannot access it. This study evaluated feasibility, acceptability, and preliminary treatment effects of a parental guided self-help (GSH) version of FBT for adolescent AN. METHOD This was a case-series design. Parents of medically stable adolescents (11-18 years) with DSM-5 AN were recruited over 12 months. Parents received online training in parental GSH FBT and 12 20-30 min GSH sessions by phone or online over 6 months. Recruitment, dropout, changes in weight, and eating-related psychopathology were assessed. Analyses used mixed modeling that included all data for all participants. RESULTS Of the 19 families that participated, most were white (94%) and from intact families (88%). Baseline median BMI (mBMI) percent was 85.01% (SD = 4.31). Participants' mBMI percent increased to 97.31% (SD ± 7.48) at the end of treatment (EOT) (ES = 2.06; CI= 0.13-3.99). Eating-related psychopathology improved by EOT (ES = 0.58; CI=.04-1.21). Dropout rate was 21% during treatment and 33% during follow-up. DISCUSSION Parental GSH-FBT is feasible and acceptable to families willing to undertake online treatment. Follow-up data was only available for nine families (47%); thus further systematic evaluation is required before reaching conclusions about the efficacy of this approach.
Extended storage of quail, chicken, and turkey eggs. 1. Hatchability and embryonic mortality.

Abstract INTRODUCTION THE fortuitous observation of elevated frequencies of twins in stored Japanese quail eggs, clustered in only a few related families, prompted us to investigate on a larger scale the effects of extended storage on hatching eggs. Similar studies have been conducted over more than 50 years with chickens (Landauer, 1967; review) and turkeys under a variety of conditions and in a variety of genetic stocks. Data from a storage trial involving chickens and turkeys simultaneously (Abbott, Abplanalp and Asmundson; unpublished) were available for comparative purposes. Their study and our quail experiment were conducted in the same laboratory under identical storage conditions. Comparisons of the three species as to hatchability and embryonic losses after extended storage of eggs are presented in this report. Analyses of embryonic abnormalities, sex ratios, and of genetic parameters will be presented separately. MATERIALS AND METHODS All birds used in this study were maintained by the…
Computational Metabolomics: A Framework for the Million Metabolome

“Sola dosis facit venenum. ” These words of Paracelsus, “the dose makes the poison”, can lead to a cavalier attitude concerning potential toxicities of the vast array of low abundance environmental chemicals to which humans are exposed. Exposome research teaches that 80–85% of human disease is linked to environmental exposures. The human exposome is estimated to include >400,000 environmental chemicals, most of which are uncharacterized with regard to human health. In fact, mass spectrometry measures >200,000 m/z features (ions) in microliter volumes derived from human samples; most are unidentified. This crystallizes a grand challenge for chemical research in toxicology: to develop reliable and affordable analytical methods to understand health impacts of the extensive human chemical experience. To this end, there appears to be no choice but to abandon the limitations of measuring one chemical at a time. The present review looks at progress in computational metabolomics to provide probability based annotation linking ions to known chemicals and serve as a foundation for unambiguous designation of unidentified ions for toxicologic study. We review methods to characterize ions in terms of accurate mass m/z, chromatographic retention time, correlation of adduct, isotopic and fragment forms, association with metabolic pathways and measurement of collision-induced dissociation products, collision cross section, and chirality. Such information can support a largely unambiguous system for documenting unidentified ions in environmental surveillance and human biomonitoring. Assembly of this data would provide a resource to characterize and understand health risks of the array of low-abundance chemicals to which humans are exposed. Corresponding Author: Department of Medicine, Pulmonary Division, Emory University, 205 Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322. Tel: 404-727-5970. Fax: 404-712-2974. dpjones@emory.edu. Special Issue: Mass Spectrometry and Emerging Technologies for Biomarker Discovery in the Assessment of Human Health and Disease Notes The authors declare no competing financial interest. HHS Public Access Author manuscript Chem Res Toxicol. Author manuscript; available in PMC 2017 March 31. Published in final edited form as: Chem Res Toxicol. 2016 December 19; 29(12): 1956–1975. doi:10.1021/acs.chemrestox. 6b00179. A uhor M anscript
Cooperative and adaptive transboundary water governance in Canada’s Mackenzie River Basin: status and prospects

Canada’s Mackenzie River Basin (MRB) is one of the largest relatively pristine ecosystems in North America. Home to indigenous peoples for millennia, the basin is also the site of increasing resource development, notably fossil fuels, hydroelectric power resources, minerals, and forests. Three provinces, three territories, the Canadian federal government, and Aboriginal governments (under Canada’s constitution, indigenous peoples are referred to as “Aboriginal”) have responsibilities for water in the basin, making the MRB a significant setting for cooperative, transboundary water governance. A framework agreement that provides broad principles and establishes a river basin organization, the MRB Board, has been in place since 1997. However, significant progress on completing bilateral agreements under the 1997 Mackenzie River Basin Transboundary Waters Master Agreement has only occurred since 2010. We considered the performance of the MRB Board relative to its coordination function, accountability, legitimacy, and overall environmental effectiveness. This allowed us to address the extent to which governance based on river basin boundaries, a bioregional approach, could contribute to adaptive governance in the MRB. Insights were based on analysis of key documents and published studies, 19 key informant interviews, and additional interactions with parties involved in basin governance. We found that the MRB Board’s composition, its lack of funding and staffing, and the unwillingness of the governments to empower it to play the role envisioned in the Master Agreement mean that as constituted, the board faces challenges in implementing a basin-wide vision. This appears to be by design. The MRB governments have instead used the bilateral agreements under the Master Agreement as the primary mechanism through which transboundary governance will occur. A commitment to coordinating across the bilateral agreements is needed to enhance the prospects for adaptive governance in the basin.
Capturing goats: documenting two hundred years of mitochondrial DNA diversity among goat populations from Britain and Ireland

The domestic goat (Capra hircus) plays a key role in global agriculture, being especially prized in regions of marginal pasture. However, the advent of industrialized breeding has seen a dramatic reduction in genetic diversity within commercial populations, while high extinction rates among feral herds have further depleted the reservoir of genetic variation available. Here, we present the first survey of whole mitochondrial genomic variation among the modern and historical goat populations of Britain and Ireland using a combination of mtDNA enrichment and high throughput sequencing. Fifteen historical taxidermy samples, representing the indigenous ‘Old Goat’ populations of the islands, were sequenced alongside five modern Irish dairy goats and four feral samples from endangered populations in western Ireland. Phylogenetic and network analyses of European mitochondrial variation revealed distinct groupings dominated by historical British and Irish samples, which demonstrate a degree of maternal genetic structure between the goats of insular and continental Europe. Several Irish modern feral samples also fall within these clusters, suggesting continuity between these dwindling populations and the ancestral ‘Old Goats’ of Ireland and Britain.
Validating the Quality of Crowdsourced Psychometric Personality Test Items

Personality questionnaire items are normally written by experts in personality theory or psychometrics. This makes personality test development expensive, especially since as many as 40% of the items are discarded after quantitative analysis. Could the crowd create personality items that are as good as the ones developed by professionals? We analyze the psychometric quality of 164 Big Five personality items generated by the crowd (n=82) and show that non-expert item writers are capable of designing high quality personality items. The analysis revealed that 59% of the crowdsourced items had adequate psychometric properties, and thus could be used as an alternative instrument to measure Big Five personality traits. We conclude that crowdsourcing personality items is a possible strategy to generate new items rapidly. We also discuss some of the challenges of crowdsourcing general psychological items.
Epidemiologic Measures for Quantifying the Incidence of Concussion in National Collegiate Athletic Association Sports.

CONTEXT Injury rates compare the relative frequency of sport-related concussions across groups. However, they may not be intuitive to policy makers, parents, or coaches in understanding the likelihood of concussion. OBJECTIVE To describe 4 measures of incidence (athlete-based rate, athlete-based risk, team-based rate, and team-based risk) during the 2011-2012 through 2014-2015 academic years. DESIGN Descriptive epidemiology study. SETTING Aggregate injury and exposure data collected from the National Collegiate Athletic Association Injury Surveillance Program in 13 sports (men's baseball, basketball, football, ice hockey, lacrosse, soccer, and wrestling and women's basketball, ice hockey, lacrosse, soccer, softball, and volleyball). PATIENTS OR OTHER PARTICIPANTS Collegiate student-athletes. MAIN OUTCOME MEASURE(S) Sport-related concussion data from the National Collegiate Athletic Association Injury Surveillance Program during the 2011-2012 through 2014-2015 academic years were analyzed. We calculated concussion rates per 1000 athlete-exposures (AEs), concussion risk, average number of concussions per team, and percentage of teams with at least 1 concussion. RESULTS During the 2011-2012 through 2014-2015 academic years, 1485 concussions were sustained by 1410 student-athletes across 13 sports. Concussion rates ranged from 0.09/1000 AEs in men's baseball to 0.89/1000 AEs in men's wrestling. Concussion risk ranged from 0.74% in men's baseball to 7.92% in men's wrestling. The average ± SD number of concussions per team ranged from 0.25 ± 0.43 in men's baseball to 5.63 ± 5.36 in men's football. The percentage of teams with a concussion ranged from 24.5% in men's baseball to 80.6% in men's football. CONCLUSIONS Although men's wrestling had a higher concussion rate and risk, men's football had the largest average number of concussions per team and the largest percentage of teams with at least 1 concussion. The risk of concussion, average number of concussions per team, and percentage of teams with concussions may be more intuitive measures of incidence for decision makers. Calculating these additional measures is feasible within existing injury surveillance programs, and this method can be applied to other injury types.
Stunting syndrome in broilers: effect of stunting syndrome inoculum obtained from stunting syndrome affected broilers, on broilers, leghorns and turkey poults.

Responses to stunting syndrome (SS) infective material obtained from affected broilers and administered per os were monitored for 3 wk in a fast-growing commercial broiler population, in slow-growing Leghorn chicks, and in turkey poults. At 2 and 3 wk, the size of the gastrointestinal tract (GIT) segments, the pH of the GIT contents, and the activities of digestive enzymes in the intestinal contents and of disaccharidases on the jejunum mucosae were determined. Inoculation affected the genetic stocks differently. In broiler chicks, growth and feed utilization were markedly reduced. In contrast, inoculation of Leghorns was accompanied by improved feed intake and growth rate. Performance of poults was affected only slightly, albeit significantly. The effect of inoculation on the pH of crop and intestinal contents in Leghorn chicks was opposite to that found in broiler chicks, i.e., a significant increase in the crop and small intestinal pH in the former vs a significant decrease in inoculated broilers. Although inoculation of the broiler chicks did not affect the pH in the proventriculus, in Leghorn chicks it was reduced by 25%. In poults, inoculation did not significantly affect GIT contents pH. The GIT segments were markedly enlarged in broiler chicks, whereas in Leghorn chicks the opposite trend was observed; namely, intestinal segment weights were significantly reduced. In poults, inoculation caused a reduction in the intestinal segments and gizzard weight at 3 wk. During this same period, the liver and pancreas relative weights were dramatically increased in broiler chicks. A higher relative heart weight at 2 wk was observed in broilers and poults; this trend persisted to Week 3 in poults but not in broiler chicks. In broiler chicks, a nonsignificant reduction was observed for all enzymes assayed at 3 wk and for chymotrypsin at 2 wk. In Leghorn chicks, inoculation was accompanied by a marked and significant increase in the activity of chymotrypsin during both periods. In poults, inoculation caused a marked increase in the activities of amylase during Week 2 and 3, and trypsin at 3 wk. Maltase and saccharase activities in the jejunum of broiler chicks were slightly depressed a t 2 and 3 wk, the depression being significant at 2 wk for maltase and at 3 wk for saccharase. In the Leghorn chicks, inoculation caused a twofold increase in the activities of both enzymes. As in Leghorns, inoculation of poults with SS infective material caused a marked increase in the activities of the disaccharidases. The different responses to SS inoculation in the different genetic stocks are discussed.
cGANs with Projection Discriminator

We propose a novel, projection based way to incorporate the conditional information into the discriminator of GANs that respects the role of the conditional information in the underlining probabilistic model. This approach is in contrast with most frameworks of conditional GANs used in application today, which use the conditional information by concatenating the (embedded) conditional vector to the feature vectors. With this modification, we were able to significantly improve the quality of the class conditional image generation on ILSVRC2012 (ImageNet) 1000-class image dataset from the current state-of-the-art result, and we achieved this with a single pair of a discriminator and a generator. We were also able to extend the application to super-resolution and succeeded in producing highly discriminative super-resolution images. This new structure also enabled high quality category transformation based on parametric functional transformation of conditional batch normalization layers in the generator.
Understanding the evolution of personality requires the study of mechanisms behind the development and life history of personality traits

Research on animal personality explains the coexistence of distinct behavioural phenotypes within a species and demonstrates limits to individual plasticity. However, the mechanisms guiding the lifelong development of personality should receive more attention, because many elements of personality are emergent properties of interactions between the environment and an individual's genetic background. In these interactions, mechanisms (e.g. genetic regulatory networks, epigenetic processes and neuroendocrine regulation) influencing personality may be modified. An approach integrating proximate mechanisms with a view of lifelong personality development will crucially improve understanding stability, plasticity and inter-individual variability of personalities and clarify the effects of selection on the phenomenon.
On the Power-of-d-choices with Least Loaded Server Selection

Motivated by distributed schedulers that combine the power-of-d-choices with late binding and systems that use replication with cancellation-on-start, we study the performance of the LL(d) policy which assigns a job to a server that currently has the least workload among d randomly selected servers in large-scale homogeneous clusters. We consider general job size distributions and propose a partial integro-differential equation to describe the evolution of the system. This equation relies on the earlier proven ansatz for LL(d) which asserts that the workload distribution of any finite set of queues becomes independent of one another as the number of servers tends to infinity. Based on this equation we propose a fixed point iteration for the limiting workload distribution and study its convergence.