Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness of Intermittent Iron Treatment of Two- to Six-Year-Old Jordanian Children with Iron-Deficiency Anemia

Background Iron deficiency is a common nutritional problem in young children among vulnerable populations in Jordan. Several studies have shown the effectiveness of intermittent iron supplementation in improving iron status. Such a study has not been carried out in 2- to-6-year-old Jordanian children diagnosed with iron deficiency anemia in a clinical setting. Objective To study the effectiveness of intermittent versus daily iron treatment in a clinical setting in 2- to 6-year-old Jordanian children with iron-deficiency anemia. Methods About 4,400 children aged 2 to 6 years who visited Prince Hashim Military Hospital in Zarqa, Jordan, from August 2000 to June 2001 were screened for age, general health, and birthweight. About 10% of these children were screened for anemia, using complete blood count (defined as a hemoglobin level ≤ 10.5 g/dL, and a mean corpuscular volume ≤ 75 fL). Anemic children underwent further screening for iron deficiency, defined as serum ferritin level ≤ 12 μ g/L. Children with iron-deficiency anemia, as indicated by hemoglobin ≤ 10.5 g/dL, mean corpuscular volume ≤ 75 fL, and serum ferritin ≤ 12 μ g/L, or as indicated by mean corpuscular volume ≤ 75 fL and hemoglobin ≤ 10.5 g/dL, were enrolled in the study after informed oral consent by their parents. Study children (n = 134) were assigned randomly to one of three groups. Subjects in group 1 (n = 45), group 2 (n = 45), and group 3 (n = 44) received iron treatment daily, weekly, and twice weekly, respectively. Out of 134 children recruited for the study, only 63 (39 boys and 24 girls) completed the 3-month treatment period. All of the children received medicinal iron drops at a dosage of 5 mg elemental iron as ferrous sulfate per kilogram of body weight. The parents also received nutritional counseling. Results At the end of treatment, hemoglobin, serum ferritin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration increased significantly in all groups with no significant differences between groups. The increases in hemoglobin in groups 1, 2, and 3 were 2.47 ± 0.17, 2.12 ± 0.18, and 2.18 ± 0.18 g/dL, respectively. Measurements of final serum ferritin concentration were available for only 12, 12, and 10 children in groups 1, 2, and 3, respectively. In all children who completed the study, except for one in group 1, hemoglobin, mean corpuscular volume, and serum ferritin reached normal values in response to iron treatment. Conclusions Weekly and twice-weekly iron therapy with 5 mg elemental iron as ferrous sulfate per kilogram of body weight accompanied by nutritional counseling was as effective as daily iron therapy in correcting iron-deficiency anemia in 2- to 6-year-old children under the clinical conditions of this study.
Regulation of integrin activation through the B-cell receptor

Effective immune surveillance is absolutely dependent on the migration of lymphocytes throughout the body and on their successful recognition of specific antigens. Both of these functions rely on the capacity of integrins that are expressed on the surface of lymphocytes to respond in a highly regulated manner to a variety of chemokines and antigens. This Commentary is primarily concerned with the role of the B-cell integrins LFA-1 and VLA-4 in the antigen-recognition process, and summarises what is currently known about the molecular mechanisms of `inside-out' integrin activation in response to B-cell-receptor stimulation. Recent investigations have identified Vav, PI3K and small GTPases as crucial regulators of the inside-out activation of B-cell integrins. These observations are of particular interest as they allude to an underlying mechanism by which B-cell-receptor-mediated signalling is linked to cytoskeleton reorganisation and subsequent integrin activation.
Every little piece counts: the many faces of tRNA transcripts

For over half a century, tRNAs have been exclusively known as decoders of genomic information. However, recent reports evidenced that tRNA transcripts are also bearers of functional RNAs, which are able to execute various tasks through an array of mechanisms. Here, we succinctly review the diversity and functions of RNAs deriving from tRNA loci.
A General Framework for Convex Relaxation of Polynomial Optimization Problems over Cones

The class of POPs (Polynomial Optimization Problems) over cones covers a wide range of optimization problems such as 0-1 integer linear and quadratic programs, nonconvex quadratic programs and bilinear matrix inequalities. This paper presents a new framework for convex relaxation of POPs over cones in terms of linear optimization problems over cones. It provides a unified treatment of many existing convex relaxation methods based on the lift-and-project linear programming procedure, the reformulation- linearization technique and the semidefinite programming relaxation for a variety of problems. It also extends the theory of convex relaxation methods, and thereby brings flexibility and richness in practical use of the theory.
Interconnecting eyeballs to content: a shapley value perspective on isp peering and settlement

Internet service providers (ISPs) must interconnect to provide global Internet connectivity to users. The payment structure of these interconnections are often negotiated and maintained via bilateral agreements. Current differences of opinion in the appropriate revenue model in the Internet has on occasion caused ISPs to de-peer from one another, hindering network connectivity and availability. Our previous work demonstrates that the Shapley value has several desirable properties, and that if applied as the revenue model, selfish ISPs would yield globally optimal routing and interconnecting decisions. In this paper, we focus our investigation of Shapley value in networks with two basic classes of ISP: content and eyeball. In particular, we analyze the revenue distribution between ISPs with elastic and inelastic customer demands, and calculate the bilateral payments between ISPs that implement the Shapley revenue. Our results illustrate how ISP revenues are influenced by different demand models. In particular, the marginal revenue lost by de-peering for an eyeball ISP with inelastic demand is inversely proportional to the square of its degree of connectivity to content ISPs. In practice, these results provide a guideline for ISPs, even in peering relationships, to negotiate bilateral payments and for regulatory institutions to design pricing regulations.
Is Staged External Fixation a Valuable Strategy for War Injuries to the Limbs?

High-energy weapons or blast injuries usually result in substantial tissue damage and are serious medical and public health problems. We report our experience with staged external fixation for war injuries to the extremities. Forty-seven patients with 64 high-energy limb fractures caused by war weapons were retrospectively reviewed. The fractures were associated with severe soft tissue damage. There were 14 Gustilo-Anderson Type IIIA fractures, 40 Type IIIB fractures, and 10 Type IIIC fractures. Soft tissue débridement followed by axial realignment of the fractured bones with immediate skeletal stabilization using the AO/ASIF unilateral tubular external fixator was performed on the day of admission. The primary tubular fixators were exchanged 5 to 7 days later for Ilizarov frames. Delayed primary closure, skin grafts, or flaps were used for soft tissue coverage. The mean followup was 40 months, and the Ilizarov/hybrid external fixator was the definitive treatment in all patients. Bone union was achieved at an average of 8 months in 58 (90.6%) fractures. Three patients had nonunions and one patient required an amputation. Two patients were lost to followup. Staged external fixation is a valuable strategy for treatment of war injuries to the extremities. Level of Evidence: Therapeutic study, Level IV. See the Guidelines for Authors for a complete description of levels of evidence
Synchronization of Motor Neurons during Locomotion in the Neonatal Rat: Predictors and Mechanisms

We describe here the robust synchronization of motor neurons at a millisecond time scale during locomotor activity in the neonatal rat. Action potential activity of motor neuron pairs was recorded extracellularly using tetrodes during locomotor activity in thein vitro neonatal rat spinal cord. Approximately 40% of motor neuron pairs recorded in the same spinal segment showed significant synchronization, with the duration of the central peak in cross-correlograms between motor neurons typically ranging between ∼30 and 100 msec. The percentage of synchronized motor neuron pairs was considerably higher for pairs with similar locomotor-related activity and strong rhythmic modulation. We also found synchronization between the activities of different motor pools, even if located several segments apart. Such distant synchronization was abolished in the absence of chemical synapses, although local coupling between motor neurons persisted. On the other hand, both local and distant coupling between motor neurons were preserved after antagonism of gap junction coupling between motor neurons. These results demonstrate that motor neuron activity is strongly synchronized at a millisecond time scale during the production of locomotor activity in the neonatal rat. These results also demonstrate that chemical synaptic inputs, in addition to electrical synapses, contribute to this synchronization, suggesting the existence of multiple mechanisms underlying motor neuron synchronization in the neonatal rat. The fast synchronization described here might be involved in activity-dependent processes during development or in the coordination of individual motor neurons into a functional population underlying behavior.
Zerumbone Induces Heme Oxygenase-1 Expression in Mouse Skin and Cultured Murine Epidermal Cells through Activation of Nrf2

Zerumbone, a sesquiterpene derived from tropical ginger, contains an electrophilic α,β-unsaturated carbonyl moiety and was found to suppress chemically induced papilloma formation in mouse skin. Here, we report that topical application of zerumbone onto dorsal skin of hairless mice induces activation of NF-E2–related factor 2 (Nrf2) and expression of heme oxygenase-1 (HO-1). We compared the levels of HO-1 protein in the skin of zerumbone-treated Nrf2 wild-type and Nrf2 knockout mice, and nrf2-deficient mice expressed HO-1 protein to a much lesser extent than the wild-type animals following topical application of zerumbone. Treatment of mouse epidermal JB6 cells with zerumbone caused a marked increase of Nrf2 nuclear translocation followed by the promoter activity of HO-1, and also enhanced direct binding of Nrf2 to the antioxidant response element. Moreover, knockdown of Nrf2 in JB6 cells diminished the zerumbone-induced upregulation of HO-1. Notably, α-humulene and 8-hydroxy-α-humulene, the structural analogues of zerumbone that lack the α,β-unsaturated carbonyl group, failed to activate Nrf2 and were unable to increase HO-1 expression. Unlike zerumbone, these nonelectrophilic analogues could not suppress the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced JB6 cell transformation and the intracellular accumulation of reactive oxygen species (ROS). Interestingly, when JB6 cells were treated with carbon monoxide–releasing molecule that mimics the HO-1 activity, the TPA-induced ROS production was markedly reduced. Taken together, these findings suggest that upregulation of HO-1 expression by zerumbone is mediated through activation of Nrf2 signaling, which provides a mechanistic basis for the chemopreventive effects of this sesquiterpene on mouse skin carcinogenesis. Cancer Prev Res; 4(6); 860–70. ©2011 AACR.
Distribution and Properties of Functional Postsynaptic Kainate Receptors on Neocortical Layer V Pyramidal Neurons

The distribution of glutamate receptor subtypes on the surface of neurons is highly relevant for synaptic transmission and signal processing. In the present study we investigated the location and properties of functional kainate receptors (KARs) on the somatodendritic membrane of rat neocortical layer V pyramidal neurons. Infrared-guided laser stimulation was used to apply glutamate photolytically to the soma and various sites along the apical dendrite. Electrical currents, resulting from the activation of pharmacologically isolated KARs, were measured by whole-cell patch-clamp recording. In addition, KARs on somatic and dendritic outside-out patches were activated while still within the brain tissue. We found that functional KARs are located on the entire somatodendritic membrane that was examined. Fast kinetics, a linear I-V relationship, and a relatively high single-channel conductance are characteristic features of these receptors. We provide evidence that the unitary properties of somatic and dendritic KARs are identical. Regarding the subcellular distribution of KARs, our results indicate that the density of these receptors increases toward the distal dendrite. They are located mainly at extrasynaptic sites but also mediate fast synaptic signaling triggered by afferent stimulation. The differential distribution speaks in favor of a selective targeting of KARs on central neurons and may reflect a mechanism for a location-dependent regulation of synaptic efficacy. Furthermore, it is feasible to assume that extrasynaptic KARs could be activated by a “spillover” of synaptically released glutamate, ambient glutamate in the CSF, or glutamate released from adjacent astrocytes.
Combining Brain–Computer Interfaces and Assistive Technologies: State-of-the-Art and Challenges

In recent years, new research has brought the field of electroencephalogram (EEG)-based brain–computer interfacing (BCI) out of its infancy and into a phase of relative maturity through many demonstrated prototypes such as brain-controlled wheelchairs, keyboards, and computer games. With this proof-of-concept phase in the past, the time is now ripe to focus on the development of practical BCI technologies that can be brought out of the lab and into real-world applications. In particular, we focus on the prospect of improving the lives of countless disabled individuals through a combination of BCI technology with existing assistive technologies (AT). In pursuit of more practical BCIs for use outside of the lab, in this paper, we identify four application areas where disabled individuals could greatly benefit from advancements in BCI technology, namely, “Communication and Control”, “Motor Substitution”, “Entertainment”, and “Motor Recovery”. We review the current state of the art and possible future developments, while discussing the main research issues in these four areas. In particular, we expect the most progress in the development of technologies such as hybrid BCI architectures, user–machine adaptation algorithms, the exploitation of users’ mental states for BCI reliability and confidence measures, the incorporation of principles in human–computer interaction (HCI) to improve BCI usability, and the development of novel BCI technology including better EEG devices.
The High‐Affinity Immunoglobulin‐E Receptor (FceRI) is Endocytosed by an AP‐2/Clathrin‐Independent, Dynamin‐Dependent Mechanism

Aggregation of the high‐affinity immunoglobulin E (IgE) receptor (FcɛRI), expressed on mast cells and basophils, initiates the immediate hypersensitivity reaction. Aggregated FcɛRI has been reported to rapidly migrate to lipid rafts in RBL‐2H3 cells. We confirmed that aggregated FcɛRI is found in the lipid raft fractions of cellular lysates. Furthermore, we show that the cross‐linked FcɛRI remains associated with detergent‐resistant structures upon internalization. Previous morphological studies have reported that aggregated FcɛRI is endocytosed via clathrin‐coated pits, which in general are not lipid raft associated. To address this apparent discrepancy, we employed siRNA to suppress expression of components of the clathrin‐mediated internalization machinery, namely, clathrin heavy chain, and the AP‐2 (α‐adaptin or µ2‐subunit). Transferrin receptor (TfR) is endocytosed by a clathrin‐mediated process and, as expected, each transfected siRNA caused a two to threefold elevation of TfR surface expression and almost completely inhibited its endocytosis. In contrast, there was no effect on surface expression levels of FcɛRI nor on the endocytosis of the dinitrophenyl‐human serum albumin (DNP‐HSA)/IgE/FcɛRI complex. On the contrary, internalization of DNP‐HSA/IgE/FcɛRI was inhibited by overexpression of a dominant‐negative dynamin mutant. We conclude that internalization of cross‐linked FcɛRI does not require the AP‐2/clathrin complex but is dynamin‐dependent and may be lipid raft mediated.
Organisational professional conflict and hybrid clinician managers: the effects of dual roles in Australian health care organizations.

PURPOSE This article aims to examine tensions between hybrid clinician managers' professional values and health care organisations' management objectives. DESIGN/METHODOLOGY/APPROACH Data are from interviews conducted with, and observation of, 14 managerial participants in a Cancer Therapy Unit set in a large teaching hospital in New South Wales, Australia, who participated in a Clinical Leadership Development Program. FINDINGS The data indicate that there are tensions experienced by members of the health care organisation when a hybrid clinician manager appears to abandon the managerial role for the clinical role. The data also indicate that when a hybrid clinician manager takes on a managerial role other members of the health care organisation are required concomitantly to increase their clinical roles. RESEARCH LIMITATIONS/IMPLICATIONS Although the research was represented by a small sample and was limited to one department of a health care organisation, it is possible that other members of health care organisations experience similar situations when they work with hybrid clinician managers. Other research supports the findings. Also, this paper reports on data that emerged from a research project that was evaluating a Clinical Leadership Development Program. The research was not specifically focused on organisational professional conflict in health care organisations. PRACTICAL IMPLICATIONS This paper shows that the role of the hybrid clinician manager may not bring with it the organisational effectiveness that the role was perceived to have. Hybrid clinician managers abandoning their managerial role for their clinical role may mean that some managerial work is not done. Increasing the workload of other clinical members of the health care organisation may not be optimal for the health care organisation. ORIGINALITY/VALUE Organisational professional conflict, as a result of hybridity and divergent managerial and clinical objectives, can cause conflict which affects other organisational members and this conflict may have implications for the efficiency of the health care organisation. The extension or duality of organisational professional conflict that causes interpersonal or group conflict in other members of the organisation, to the authors' knowledge, has not yet been researched.
Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants.

OBJECTIVE To determine whether the currently available evidence supports the hypothesis that antidepressants and mood stabilizers may bring about some of their long-term therapeutic effects by regulating signal transduction pathways and gene expression in the central nervous system. METHODS To address this question, we reviewed the evidence showing that chronic administration of antidepressants and mood stabilizers involves alterations in signaling pathways and gene expression in the central nervous system. RESULTS A large body of data has shown that lithium and valproate exert effects on the protein kinase C signaling pathway and the activator protein 1 family of transcription factors; in contrast, antidepressants affect the cyclic adenosine monophosphate pathway and may bring about their therapeutic effects by modulating cyclic adenosine monophosphate-regulated gene expression in the central nervous system. CONCLUSIONS Given the key roles of these signaling cascades in the amplification and integration of signals in the central nervous system, the findings have clear implications not only for research into the etiology and pathophysiology of the severe mood disorders but also for the development of novel and innovative treatment strategies.
Competitive Adsorption of Metals onto Magnetic Graphene Oxide: Comparison with Other Carbonaceous Adsorbents

Competitive adsorption isotherms of Cu(II), Pb(II), and Cd(II) were examined on a magnetic graphene oxide (GO), multiwalled carbon nanotubes (MWCNTs), and powered activated carbon (PAC). A series of analyses confirmed the successful synthesis of the magnetic GO based on a simple ultrasonification method. Irrespective of the adsorbents, the adsorption was highly dependent on pH, and the adsorption was well described by the Langmuir isotherm model. The maximum adsorption capacities of the adsorbents were generally higher in the order of Pb(II) > Cu(II) > Cd(II), which is the same as the degree of the electronegativity and the hydrated radius of the metals, suggesting that the metal adsorption may be governed by an ion exchange between positively charged metals and negatively charged surfaces, as well as diffusion of metals into the surface layer. The adsorption of each metal was mostly lower for multi- versus single-metal systems. The antagonistic effects were influenced by solution pH as well as the type of metals, and they were higher in the order of the magnetic GO > MWCNT > PAC. Dissolved HS played a greater role than HS adsorbed onto the adsorbents, competing with the adsorption sites for metal complexation.
A Measurement Study of Internet File Transfer Traffic ; CU-CS-571-92

The lack of a topology-based information distribution mechanism in wide area networks causes users to waste a large amount of bandwidth on repeat transfers of widely accessed files. As a first step towards designing such a mechanism, in this paper we present measurements of the Internet File Transfer Protocol, gathered over two weeks at the main gateway to the University of Colorado network. We found that nearly 40% of all transfers were duplicate transmissions, accounting for over 54% of the file transmission traffic. A small proportion of files were significantly larger and more frequently transferred, with 6.30% of the files accounting for 19.30% of the transfers. 8.21% of duplicate file transmissions were caused by user errors when transferring binary data, underscoring the need to insulate users from such details. We also found that file transfers occurred in only 44% of the FTP connections. Other connections were probably directory-only requests, underscoring the need for better resource discovery support in the Internet. We present measurements of a number of other statistics as well, including distributions of file sizes, file types, peak transfer times, and sources and destinations.
A distributional limit law for the continued fraction digit sum

We consider the continued fraction digits as random variables measured with respect to Lebesgue measure. The logarithmically scaled and normalised fluctuation process of the digit sums converges strongly distributional to a random variable uniformly distributed on the unit interval. For this process normalised linearly we determine a large deviation asymptotic. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)