Miracle-dz/UniFAR-FTUs huggingface dataset:
Client ahead‐of‐time compiler for embedded Java platforms

Many embedded Java platforms execute two types of Java classes: those installed statically on the client device and those downloaded dynamically from service providers at run time. For achieving higher performance, the static Java classes can be compiled into machine code by ahead‐of‐time compiler (AOTC) in the server, and the translated machine code can be installed on the client device. Unfortunately, AOTC cannot be applicable to the dynamically downloaded classes. This paper proposes client‐AOTC (c‐AOTC), which performs AOTC on the client device using the just‐in‐time compiler (JITC) module installed on the device, obviating the JITC overhead and complementing the server‐AOTC. The machine code of a method translated by JITC is cached on a persistent memory of the device, and when the method is invoked again in a later run of the program, the machine code is loaded and executed directly without any translation overhead. A major issue in c‐AOTC is relocation because some of the address constants embedded in the cached machine code are not correct when the machine code is loaded and used in a different run; those addresses should be corrected before they are used. Constant pool resolution and inlining complicate the relocation problem, and we propose our solutions. The persistent memory overhead for saving the relocation information is also an issue, and we propose a technique to encode the relocation information and compress the machine code efficiently. We developed a c‐AOTC on Sun's CDC VM reference implementation, and our evaluation results indicate that c‐AOTC can improve the performance significantly, as much as an average of 12% for EEMBC and 4% for SpecJVM98, with a persistent memory overhead of 1% on average. Copyright © 2008 John Wiley & Sons, Ltd.
Remote handshaking: touch enhances video-mediated social telepresence

Since past studies on haptic and visual communication have tended to be isolated from each other, it has remained unclear whether a touch channel can still enrich mediated communication where video and audio channels are already available. To clarify this, we analyzed remote handshaking in which a robot hand that was attached just under a videoconferencing terminal's display moved according to the opening and closing motion of a conversation partner's hand. Combining touch and video channels raises a question as to whether the partner's action of touching a haptic device should be visible to the user. If it can be invisible, the action may be unnecessary, and a unilaterally controlled device may be enough to establish an effective touch channel. Our analysis revealed that the feeling of being close to the partner can be enhanced by mutual touch in which the partner's action needs to occur but should be invisible.
Molluscum Contagiosum: To Treat or Not to Treat? Experience with 170 Children in an Outpatient Clinic Setting in the Northeastern United States

Despite the high prevalence of molluscum contagiosum (MC) in children, epidemiologic data on this common self‐limited viral infection is limited. In this report we review our experience with the demographic characteristics, clinical characteristics, management, and time to resolution of MC in 170 children. A retrospective medical chart review and telephone survey were conducted on children younger than 16 years of age evaluated for MC in the Division of Pediatric Dermatology at the Johns Hopkins Children's Center, Baltimore, Maryland, from January 1, 2008, to December 31, 2011. Of 170 children with MC, 51.8% were female and 77.1% were Caucasian. The median age at diagnosis was 5 years and 46.5% had a history of atopic dermatitis (AD). Children with AD had significantly more MC lesions than those without (p < 0.05); 72.9% of children did not receive any treatment. MC lesions completely cleared within 12 months in 45.6% of treated and 48.4% of untreated children and within 18 months in 69.5% of treated and 72.6% of untreated children. Treatment (if any), sex, race, diagnosing physician, number of lesions at diagnosis, number of anatomic locations, or history of AD did not predict time to resolution of MC lesions. MC lesions completely resolved in approximately 50% of children within 12 months and in 70% within 18 months. Treatment did not shorten the time to resolution.
Evaluation of the synchronous generation and sampling technique

The simultaneous synchronous generation and sampling technique allows alternating current (AC) quantities (root mean square (RMS) values of voltage, voltage ratios, and power) to be determined with uncertainties of the order of a few parts in 10/sup 6/. Mathematical models for estimating measurement uncertainties and experimental comparisons of such a system against existing primary standards at the PTB were carried out.
Handling of hemmed fabrics by a single-armed robot

We describe here a mechanical system that can grasp, unfold, and position fabrics in a series of motions. Fabric setting process by a human consists of wiping, pinching, unfolding, and placing motions. This setting process can be performed using a single-armed robot with a gripper hand having four degrees of freedom. For grasping the fabric, the robotic gripper wrinkles part of it, causing residual deformation. During the unfolding motion, the robot can perform a pinching slip motion, in which fingertips slip on the fabric surface while grasping, similar to a human unfolding motion.
Bronchodilators accelerate the dynamics of muscle O2 delivery and utilisation during exercise in COPD

Background Expiratory flow limitation and lung hyperinflation promote cardiocirculatory perturbations that might impair O2 delivery to locomotor muscles in patients with chronic obstructive pulmonary disease (COPD). The hypothesis that decreases in lung hyperinflation after the inhalation of bronchodilators would improve skeletal muscle oxygenation during exercise was tested. Methods Twelve non- or mildly hypoxaemic males (forced expiratory volume in 1 s (FEV1)=38.5±12.9% predicted; Pao2>60 mm Hg) underwent constant work rate cycle ergometer exercise tests (70–80% peak) to the limit of tolerance (Tlim) after inhaled bronchodilators (salbutamol plus ipratropium) or placebo. Muscle (de)oxygenation (∼fractional O2 extraction) was determined in the vastus lateralis by changes (Δ) in the deoxyhaemoglobin/myoglobin signal ([HHb]) from near-infrared spectroscopy, and cardiac output (QT) was monitored by impedance cardiography. Results Bronchodilators reduced lung hyperinflation and increased Tlim compared with placebo (454±131 s vs 321±140 s, respectively; p<0.05). On-exercise kinetics of QT and pulmonary O2 uptake (V˙o2) were accelerated with active treatment; Δ[HHb] dynamics, however, were delayed by ∼78% and the signal amplitude diminished by ∼21% (p<0.01). Consequently, the ratio between V˙o2 and Δ[HHb] dynamics decreased, suggesting improved microvascular O2 delivery (τ-V˙o2/MRT-Δ[HHb]=4.48±1.57 s vs 2.08±1.15 s, p<0.05). Of note, reductions in lung hyperinflation were related to faster QT kinetics and larger decrements in τ-V˙o2/MRT-Δ[HHb] (p<0.01). Conclusions Decreases in operating lung volumes after the inhalation of bronchodilators are associated with faster ‘central’ cardiovascular adjustments to high-intensity exercise with beneficial consequences on muscle oxygenation in patients with moderate to severe COPD.
Bilevel Optimal Control With Final-State-Dependent Finite-Dimensional Lower Level

In this paper we discuss special bilevel optimal control problems where the upper level problem is an optimal control problem of ODEs with control and terminal constraints and the lower level problem is a finite-dimensional parametric optimization problem where the parameter is the final state of the state variable of the upper level. We tackle this problem using tools from nonsmooth analysis, optimization in Banach spaces, and bilevel programming to derive necessary optimality conditions of linearized Pontryagin-type.
No Fitness Cost for Wheat's H Gene-Mediated Resistance to Hessian Fly (Diptera: Cecidomyiidae)

ABSTRACT Resistance (R) genes have a proven record for protecting plants against biotic stress. A problem is parasite adaptation via Avirulence (Avr) mutations, which allows the parasite to colonize the R gene plant. Scientists hope to make R genes more durable by stacking them in a single cultivar. However, stacking assumes that R gene-mediated resistance has no fitness cost for the plant. We tested this assumption for wheat's resistance to Hessian fly, Mayetiola destructor (Say) (Diptera: Cecidomyiidae). Our study included ten plant fitness measures and four wheat genotypes, one susceptible, and three expressing either the H6, H9, or H13 resistance gene. Because R gene-mediated resistance has two components, we measured two types of costs: the cost of the constitutively-expressed H gene, which functions in plant surveillance, and the cost of the downstream induced responses, which were triggered by Hessian fly larvae rather than a chemical elicitor. For the constitutively expressed H gene, some measures indicated costs, but a greater number of measures indicated benefits of simply expressing the H gene. For the induced resistance, instead of costs, resistant plants showed benefits of being attacked. Resistant plants were more likely to survive attack than susceptible plants, and surviving resistant plants produced higher yield and quality. We discuss why resistance to the Hessian fly has little or no cost and propose that tolerance is important, with compensatory growth occurring after H gene-mediated resistance kills the larva. We end with a caution: Given that plants were given good growing conditions, fitness costs may be found under conditions of greater biotic or abiotic stress.
Cbl Enforces Vav1 Dependence and a Restricted Pathway of T Cell Development

Extensive studies of pre-TCR- and TCR-dependent signaling have led to characterization of a pathway deemed essential for efficient T cell development, and comprised of a cascade of sequential events involving phosphorylation of Lck and ZAP-70, followed by phosphorylation of LAT and SLP-76, and subsequent additional downstream events. Of interest, however, reports from our lab as well as others have indicated that the requirements for ZAP-70, LAT, and SLP-76 are partially reversed by inactivation of c-Cbl (Cbl), an E3 ubiquitin ligase that targets multiple molecules for ubiquitination and degradation. Analysis of signaling events in these Cbl knockout models, including the recently reported analysis of SLP-76 transgenes defective in interaction with Vav1, suggested that activation of Vav1 might be a critical event in alternative pathways of T cell development. To extend the analysis of signaling requirements for thymic development, we have therefore assessed the effect of Cbl inactivation on the T cell developmental defects that occur in Vav1-deficient mice. The defects in Vav1-deficient thymic development, including a marked defect in DN3-DN4 transition, were completely reversed by Cbl inactivation, accompanied by enhanced phosphorylation of PLC-γ1 and ERKs in response to pre-TCR/TCR cross-linking of Vav1-/-Cbl-/- DP thymocytes. Taken together, these results suggest a substantially modified paradigm for pre-TCR/TCR signaling and T cell development. The observed consensus pathways of T cell development, including requirements for ZAP-70, LAT, SLP-76, and Vav1, appear to reflect the restriction by Cbl of an otherwise much broader set of molecular pathways capable of mediating T cell development.
Time Course-Dependent Methanogenic Crude Oil Biodegradation: Dynamics of Fumarate Addition Metabolites, Biodegradative Genes, and Microbial Community Composition

Biodegradation of crude oil in subsurface petroleum reservoirs has adversely impacted most of the world's oil, converting this resource to heavier forms that are of lower quality and more challenging to recover. Oil degradation in deep reservoir environments has been attributed to methanogenesis over geological time, yet our understanding of the processes and organisms mediating oil transformation in the absence of electron acceptors remains incomplete. Here, we sought to identify hydrocarbon activation mechanisms and reservoir-associated microorganisms that may have helped shape the formation of biodegraded oil by incubating oilfield produced water in the presence of light (°API = 32) or heavy crude oil (°API = 16). Over the course of 17 months, we conducted routine analytical (GC, GC-MS) and molecular (PCR/qPCR of assA and bssA genes, 16S rRNA gene sequencing) surveys to assess microbial community composition and activity changes over time. Over the incubation period, we detected the formation of transient hydrocarbon metabolites indicative of alkane and alkylbenzene addition to fumarate, corresponding with increases in methane production and fumarate addition gene abundance. Chemical and gene-based evidence of hydrocarbon biodegradation under methanogenic conditions was supported by the enrichment of hydrocarbon fermenters known to catalyze fumarate addition reactions (e.g., Desulfotomaculum, Smithella), along with syntrophic bacteria (Syntrophus), methanogenic archaea, and several candidate phyla (e.g., “Atribacteria”, “Cloacimonetes”). Our results reveal that fumarate addition is a possible mechanism for catalyzing the methanogenic biodegradation of susceptible saturates and aromatic hydrocarbons in crude oil, and we propose the roles of community members and candidate phyla in our cultures that may be involved in hydrocarbon transformation to methane in crude oil systems.
Search continuous nearest neighbors on the air

A continuous nearest neighbor (CNN) search retrieves the nearest neighbors corresponding to every point in a given query line segment. It is important for location-based services such as vehicular navigation tools and tourist guides. It is infeasible to answer a CNN search by issuing a traditional nearest neighbor query at every point of the line segment due to the large number of queries generated and the large overhead on bandwidth. Algorithms have been proposed recently to support CNN search in the traditional client-server service model. In this paper, we conduct a pioneering study on CNN search in wireless data broadcast environments. We propose two air indexing techniques, namely, R-tree air index and Hilbert curve air index, and develop algorithms based on these two techniques to search CNNs on the air. A simulation is conducted to compare the proposed air indexing techniques with a naive broadcast approach. The result shows that both of the proposed methods outperform the naive approach significantly. The Hilbert Curve air index is superior for uniform data distributions, while the R-tree air index is a better choice for skewed data distributions.
Solving linear matrix equations with SLICOT

We discuss solvers for Sylvester, Lyapunov, and Stein equations that are available in the SLICOT Library (Subroutine Library In COntrol Theory). These solvers offer improved efficiency, reliability, and functionality compared to corresponding solvers in other computer-aided control system design packages. The performance of the SLICOT solvers is compared with the corresponding Matlab solvers.
Detection of Human Picornaviruses by Multiplex Reverse Transcription-PCR and Liquid Hybridization

ABSTRACT A qualitative multiplex reverse transcription (RT)-PCR and liquid hybridization assay for the detection of human enteroviruses, rhinoviruses, parechoviruses, and Aichi virus was developed. Furthermore, a separate assay for the recognition of hepatitis A virus was established to complement the test pattern so that all human picornaviruses were covered. The amplicons, which represented the 5′ untranslated regions of the viral RNA genomes, were identified in liquid hybridization reactions with genus-specific digoxigenin-labeled oligonucleotide probes. The sensitivity of the multiplex RT-PCR and liquid hybridization assay was 10 to 100 picornavirus genome equivalents for representatives of each picornavirus genus. The hepatitis A virus assay exhibited a sensitivity of 10 genome copies. Both the uniplex and the multiplex tests were highly specific for the target viruses. Twenty-three clinical samples, including cerebrospinal fluid, serum, and nasopharyngeal swab specimens, were used for clinical evaluation of the multiplex RT-PCR assay. The results obtained were consistent with the results of routine virus diagnostic assays. Furthermore, the assay was used to screen 68 stool specimens for the presence of parechoviruses and Aichi virus. One sample was found to contain parechovirus RNA, whereas no Aichi virus was detected. The assay described here can be applied for the efficient identification of human enteroviruses and rhinoviruses in clinical specimens and simultaneously enables the collection of information on the epidemiology and clinical outcomes of infections caused by the currently poorly known human parechoviruses and Aichi virus.
Tooth Size Variation Related to Age in Amboseli Baboons

We measured the molar size from a single population of wild baboons from Amboseli (Kenya), both females (n = 57) and males (n = 50). All the females were of known age; the males represented a mix of known-age individuals (n = 31) and individuals with ages estimated to within 2 years (n = 19). The results showed a significant reduction in the mesiodistal length of teeth in both sexes as a function of age. Overall patterns of age-related change in tooth size did not change whether we included or excluded the individuals of estimated age, but patterns of statistical significance changed as a result of changed sample sizes. Our results demonstrate that tooth length is directly related to age due to interproximal wearing caused by M2 and M3 compression loads. Dental studies in primates, including both fossil and extant species, are mostly based on specimens obtained from osteological collections of varying origins, for which the age at death of each individual in the sample is not known. Researchers should take into account the phenomenon of interproximal attrition leading to reduced tooth size when measuring tooth length for ondontometric purposes.
Sensor Placement with Multiple Objectives for Structural Health Monitoring in WSNs

Sensor placement plays a vital role in deploying wireless sensor networks (WSNs) for structural health monitoring (SHM) efficiently and effectively. Existing civil engineering approaches do not seriously consider WSN constraints, such as communication load, network connectivity, and fault tolerance. In this paper, we study the methodology of sensor placement optimization for SHM that addresses three key aspects: finding a high quality placement of a set of sensors that satisfies civil engineering requirements; ensuring the communication efficiency and low complexity for sensor placement; and reducing the probability of a network failure. Particularly, after the placement of a subset of sensors, we find some distance-sensitive, but unused, near optimal locations for the remaining sensors to achieve a communication-efficient WSN. By means of the placement, we present a "connectivity tree" by which structural health state or network maintenance can be achieved in a decentralized manner. We then optimize the system performance by considering multiple objectives: lifetime prolongation, low communication cost, and fault tolerance. We validate the efficiency and effectiveness of this approach through extensive simulations and a proof-ofconcept implementation on a real physical structure.
Hydrodynamics of Coarse Coal Slime and Quartz Particles in a Liquid-Solid Fluidized Bed Separator

The hydrodynamics of particles of coarse coal slime and quartz of different sizes in a liquid-solid fluidized bed separator were investigated experimentally, including minimum fluidization velocities, bed expansion ratios, and segregation of mixed particles with two methods. Experimental parameters studied included density and size of particle, superficial water velocity and initial static bed height. The results provide a reference for choice of size scope on coarse coal slime separation by liquid-solid fluidized bed separators.
Decay of calcium transients after electrical stimulation in rat fast‐ and slow‐twitch skeletal muscle fibres

1 Calcium transients were calculated from fura‐2 fluorescence signals (corrected for kinetic delays in the Ca2+–fura‐2 reaction) from single rat skeletal muscle fibres, either fully dissociated from the fast‐twitch flexor digitorum brevis (FDB) muscle or in small bundles from the slow‐twitch soleus muscle. Fibres or bundles were embedded in agarose gel to inhibit movement and stimulated by single or trains of 1–2 ms electrical pulses (100 Hz, 2–400 ms train duration). 2 The rate constant of decay of [Ca2+] determined from single‐exponential fits to the final decay phase of [Ca2+] after a single action potential was considerably faster in FDB fibres than in soleus fibres. As the stimulation duration increased, the rate constant of [Ca2+] decay decreased for both the FDB and soleus fibres, but the effect was greater in FDB than in soleus fibres. 3 Using the magnitude of the decline in the rate constant of [Ca2+] decay with increasing stimulation duration as an index of relative contribution of the saturable Ca2+ binding sites on parvalbumin, subpopulations termed ‘high’, ‘medium’ and ‘low’, referring to estimated parvalbumin content, were determined within each group of FDB and soleus fibres. In fibres assigned to the ‘high’ and ‘medium’ groups, parvalbumin was the major contributor (50.73%) to the [Ca2+] decay rate constant after a single action potential. In fibres in the ‘low’ group, parvalbumin contributed only 0–28% to the rate constant of [Ca2+] decay. 4 Fluorescence recordings using mag‐fura‐2, a lower‐affinity Ca2+ indicator expected to be in equilibrium with myoplasmic Ca2+, gave similar values for both the [Ca2+] decay rate constant after a single action potential and the decrease in this rate constant with increased stimulation duration, as found for the fura‐2 [Ca2+] transients from FDB and soleus fibres. Thus, the observed differences in decay rate of Ca2+ were not introduced by kinetic correction of the fura‐2 recordings, but are attributed to differences in the Ca2+ binding and transport properties of fast‐ and slow‐twitch mammalian fibres.
Stem Cells from Deciduous Tooth Repair Mandibular Defect in Swine

Stem cells from human exfoliated deciduous teeth have been identified as a new post-natal stem cell population with multipotential differentiation capabilities, including regeneration of mineralized tissues in vivo. To examine the efficacy of utilizing these stem cells in regenerating orofacial bone defects, we isolated stem cells from miniature pig deciduous teeth and engrafted the critical-size bone defects generated in swine mandible models. Our results indicated that stem cells from miniature pig deciduous teeth, an autologous and easily accessible stem cell source, were able to engraft and regenerate bone to repair critical-size mandibular defects at 6 months post-surgical reconstruction. This pre-clinical study in a large-animal model, specifically swine, allows for testing of a stem cells/scaffold construct in the restoration of orofacial skeletal defects and provides rapid translation of stem-cell-based therapy in orofacial reconstruction in human clinical trials.