Miracle-dz/UniFAR-FTUs huggingface dataset:
Interactions That Scaffold Reading Performance

In this article, findings from case study research of two effective literacy teachers are presented in order to describe in rich detail the nature of effective scaffolding. The teachers worked one-to-one with first-grade students who were experiencing extreme difficulty in learning to read. The complexity of scaffolding is described in terms of the instructional decisions that teachers must make on a moment-by-moment basis about the kind of help (what to work on) and level or amount of help to provide at points of difficulty during reading.
Cortical connections of areas 17 (V‐I) and 18 (V‐II) of squirrels

Connections of visual cortex in squirrels were investigated by placing WGA‐HRP injections, and in some cases fluorescent dyes, into area 17 (V‐I) or area 18 (V‐II). Results were related to architectonic fields determined in brain sections cut parallel to the surface of manually flattened cortex and to limited microelectrode mapping data. Injections in area 17 provided evidence for (1) a patchy pattern of horizontal intrinsic connections extending 1–2 mm form the injection site; (2) uneven, widely distributed connections with area 18 (V‐II) and adjoining occipital‐temporal (OT) cortex; and (3) callosal connections of large portions of area 17 with the 17/18 border zone. While restricted locations in area 17 had uneven interconnections over several mm of area 18, more rostral locations in area 17 related to more rostral locations in area 18, demonstrating a topographic tendency. Injections in area 18 revealed (1) zones of discontinuous connections with area 17 that followed a topographic pattern, (2) patches of intrinsic connections that spread over distances of up to 6–8 mm from the injection site; (3) two zones of uneven connections with OT cortex suggesting the locations of at least two visual areas, OTr and OTc; (4) connections with limbic cortex rostromedial to areas 17 and 18; (5) sparse connections with regions of temporal cortex lateral to OT; and (6) uneven callosal connections with area 18 and OT cortex. The widespread and unevenly distributed intrinsic callosal interconnection patterns of areas 17 and 18 contrast with the restricted excitatory receptive fields of neurons and the retinotopic patterns of representation in these fields. Although physiological evidence is presently lacking, the patchy connections suggest that areas 17 and 18 in squirrels are modularly organized.
Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells

Estrogen and growth factors play a major role in uterine leiomyoma (UtLM) growth possibly through interactions of receptor tyrosine kinases (RTKs) and estrogen receptor-alpha (ERα) signaling. We determined the genomic and nongenomic effects of 17β-estradiol (E2) on IGF-IR/MAPKp44/42 signaling and gene expression in human UtLM cells with intact or silenced IGF-IR. Analysis by RT2 Profiler PCR-array showed genes involved in IGF-IR/MAPK signaling were upregulated in UtLM cells by E2 including cyclin D kinases, MAPKs, and MAPK kinases; RTK signaling mediator, GRB2; transcriptional factors ELK1 and E2F1; CCNB2 involved in cell cycle progression, proliferation, and survival; and COL1A1 associated with collagen synthesis. Silencing (si)IGF-IR attenuated the above effects and resulted in upregulation of different genes, such as transcriptional factor ETS2; the tyrosine kinase receptor, EGFR; and DLK1 involved in fibrosis. E2 rapidly activated IGF-IR/MAPKp44/42 signaling nongenomically and induced phosphorylation of ERα at ser118 in cells with a functional IGF-IR versus those without. E2 also upregulated IGF-I gene and protein expression through a prolonged genomic event. These results suggest a pivotal role of IGF-IR and possibly other RTKs in mediating genomic and nongenomic hormone receptor interactions and signaling in fibroids and provide novel genes and targets for future intervention and prevention strategies.
LATITUDINAL VARIATION IN GENETIC DIVERGENCE OF POPULATIONS AND THE POTENTIAL FOR FUTURE SPECIATION

Abstract The increase in biological diversity with decreasing latitude is widely appreciated but the cause of the pattern is unknown. This pattern reflects latitudinal variation in both the origin of new species (cladogenesis) and the number of species that coexist. Here we address latitudinal variation in species origination, by examining population genetic processes that influence speciation. Previous data suggest a greater number of speciation events at lower latitudes. If speciation events occur more frequently at lower latitudes, we predicted that genetic divergence among populations within species, an important component of cladogenesis, should be greater among lower latitude populations. We tested this prediction using within-species patterns of mtDNA variation across 60 vertebrate species that collectively spanned six continents, two oceans, and 119 degrees latitude. We found greater genetic divergence of populations, controlling for geographic distance, at lower latitudes within species. This pattern remained statistically significant after removing populations that occur in localities previously covered by continental glaciers during the last glaciation. Results suggest that lower latitude populations within species exhibit greater evolutionary independence, increasing the likelihood that mutation, recombination, selection, and/or drift will lead to divergence of traits important for reproductive isolation and speciation. Results are consistent with a greater influence of seasonality, reduced energy, and/or glacial (Milankovitch) cycles acting on higher latitude populations, and represent one of the few tests of predictions of latitudinal variation in speciation rates using population genetic data.
SUBDEGREE SUNYAEV–ZEL'DOVICH SIGNAL FROM MULTIFREQUENCY BOOMERanG OBSERVATIONS

The Sunyaev–Zel'dovich (SZ) effect is the inverse Compton-scattering of cosmic microwave background (CMB) photons by hot electrons in the intervening gas throughout the universe. The effect has a distinct spectral signature that allows its separation from other signals in multifrequency CMB data sets. Using CMB anisotropies measured at three frequencies by the BOOMERanG 2003 flight we constrain SZ fluctuations in the 10 arcmin to 1 deg angular range. Propagating errors and potential systematic effects through simulations, we obtain an overall upper limit of 15.3 μK (2σ) for rms SZ fluctuations in a broad bin between multipoles of 250 and 1200 at the Rayleigh–Jeans (RJ) end of the spectrum. The resulting upper limit on the local universe normalization of the density perturbations with BOOMERanG SZ data alone is σSZ8 < 1.14 at the 95% confidence level. When combined with other CMB anisotropy and SZ measurements, we find σSZ8 < 0.92 (95% c.l.).
Effects of Cognitive-Behavioral, Reminiscence, and Activity Treatments on Life Satisfaction and Anxiety in the Elderly

This study involved an examination of effects of a cognitive-behavioral group condition, a reminiscence treatment group condition, and an activity group condition on anxiety and life satisfaction for senior citizens, aged sixty-five and older. No significant differences on life satisfaction and trait anxiety were found for the groups at pretest, posttest, and follow-up. A significant ANOVA for state anxiety at follow-up was followed by directional t-tests which were not significant in the predicted direction. The differences on state anxiety observed at follow-up appear to have resulted from improvement of the reminiscence group. Suggestions were made for further research on group treatment of the elderly.
Binding of acellular, native and cross-linked human hemoglobins to haptoglobin: enhanced distribution and clearance in the rat.

It is well established that hemoglobin resulting from red cell lysis binds to haptoglobin in plasma to form a complex. The increased molecular size precludes its filtration by the kidneys, redirecting it toward hepatocellular entry. Chemically cross-linked hemoglobins are designed to be resistant to renal excretion, even in the absence of haptoglobin. The manner in which binding to haptoglobin influences the pharmacokinetics of acellular cross-linked and native hemoglobins was investigated after intravenous injection of radiolabeled native human hemoglobin and trimesyl-(Lys82)beta-(Lys82)beta cross-linked human hemoglobin, at trace doses, into rats. Under these conditions, there is sufficient plasma haptoglobin for binding with hemoglobin. In vitro binding assayed by size-exclusion chromatography for bound and free hemoglobin revealed that, at <8 muM hemoglobin, native human hemoglobin was completely bound to rat haptoglobin, whereas only approximately 30% of trimesyl-(Lys82)beta-(Lys82)beta cross-linked hemoglobin was bound. Plasma disappearance of low doses (0.31 mumol/kg) of native and cross-linked hemoglobins was monoexponential (half-life = 23 and 33 min, respectively). The volume of distribution (40 vs. 19 ml/kg) and plasma clearance (1.22 vs. 0.4 ml.min(-1). kg(-1)) were higher for native than for cross-linked hemoglobin. Native and cross-linked human hemoglobins were found primarily in the liver, and not in the kidney, heart, lung, or spleen, mostly as degradation products. These pharmacokinetic findings suggest that the binding of hemoglobin to haptoglobin enhances its hepatocellular entry, clearance, and distribution.
A 3-D marked point process model for multi-view people detection

In this paper we introduce a probabilistic approach on multiple person localization using multiple calibrated camera views. People present in the scene are approximated by a population of cylinder objects in the 3-D world coordinate system, which is a realization of a Marked Point Process. The observation model is based on the projection of the pixels of the obtained motion masks in the different camera images to the ground plane and to other parallel planes with different height. The proposed pixel-level feature is based on physical properties of the 2-D image formation process and can accurately localize the leg position on the ground plane and estimate the height of the people, even if the area of interest is only a part of the scene, meanwhile silhouettes from irrelevant outside motions may significantly overlap with the monitored region in some of the camera views. We introduce an energy function, which contains a data term calculated from the extracted features and a geometrical constraint term modeling the distance between two people. The final configuration results (location and height) are obtained by an iterative stochastic energy optimization process, called the Multiple Birth and Death dynamics. The proposed approached is compared to a recent state-of-the-art technique in a publicly available dataset and its advantages are quantitatively demonstrated.
Adjusted bat algorithm for tuning of support vector machine parameters

Support vector machines are powerful and often used technique of supervised learning applied to classification. Quality of the constructed classifier can be improved by appropriate selection of the learning parameters. These parameters are often tuned using grid search with relatively large step. This optimization process can be done computationally more efficiently and more precisely using stochastic search metaheuristics. In this paper we propose adjusted bat algorithm for support vector machines parameter optimization and show that compared to the grid search it leads to a better classifier. We tested our approach on standard set of benchmark data sets from UCI machine learning repository. Additionally, proposed algorithm was compared to other approaches from the literature where our algorithm obtained more accurate classifiers, with larger percent of correct classifications, especially in the more realistic cases where separate test sets were used instead of cross validation only.
The tyrosine phosphatase DEP-1 induces cytoskeletal rearrangements, aberrant cell-substratum interactions and a reduction in cell proliferation

The receptor protein tyrosine phosphatase density-enhanced phosphatase-1 (DEP-1) has been implicated in aberrant cancer cell growth and immune cell function, however, its function within cells has yet to be properly elucidated. To investigate the cellular function of DEP-1, stable cell lines inducibly expressing DEP-1 were generated. Induction of DEP-1 expression was found to decrease PDGF-stimulated tyrosine phosphorylation of a number of cellular proteins including the PDGF receptor, and to inhibit growth factor-stimulated phosphorylation of components of the MAPK pathway, indicating that DEP-1 antagonised PDGF receptor signalling. This was supported by data showing that DEP-1 expression resulted in a reduction in cell proliferation. DEP-1-expressing cells had fewer actin-containing microfilament bundles, reduced vinculin and paxillin-containing adhesion plaques, and were defective in interactions with fibronectin. Defective cell-substratum adhesion correlated with lack of activation of FAK in DEP-1-expressing cells. Time-lapse interference reflection microscopy of live cells revealed that although small focal contacts at the leading edge were generated in DEP-1-expressing cells, they failed to mature into stable focal adhesions, as found in control cells. Further motility analysis revealed that DEP-1-expressing cells retained limited random motility, but showed no chemotaxis towards a gradient of PDGF. In addition, cell-cell contacts were disrupted, with a change in the localisation of cadherin from discrete areas of cell-cell contact to large areas of membrane interaction, and there was a parallel redistribution of β-catenin. These results demonstrate that DEP-1 is a negative regulator of cell proliferation, cell-substratum contacts, motility and chemotaxis in fibroblasts.
American ambivalence toward academic freedom

Why are U.S. academics, even after tenure and promotion, so timid in their exercise of academic freedom? Part of the problem is institutional – academics are subject to a long probationary period under tight collegial control – but part of the problem is ideological. A hybrid of seventeenth-century British and nineteenth-century German ideals, U.S. academia – and the nation more generally – remains ambivalent toward the value of academic freedom, ultimately inhibiting an unequivocal endorsement.
Using Simultaneous Prompting to Teach Computer-based Story Writing to a Student with Autism

Writing is a critical skill because it is used to access reinforcement in a variety of contexts. Unfortunately, there has been little research on writing skills instruction for students with intellectual disabilities and autism spectrum disorders. The purpose of this study was to evaluate the effects simultaneous prompting and computer-assisted instruction on story writing responses of a 7-year-old male with autism. Data indicated that the intervention was effective in teaching the participant to construct stories related to three different topics. Additionally, the student maintained responding at 2 and 4 weeks following intervention and increased responding across different topographies (i.e., handwriting, vocal).
Possibilities within Acceptance and Commitment Therapy for Approaching Moral Injury

Moral injury and acceptance and commitment therapy (ACT) are both topics that have only quite recently been introduced into the mental health literature. Although inquiries into these two domains have been advanced independent from one another, both challenge various aspects of the traditional medical model for diagnosing, understanding, and treating psychiatric problems. This article explores complementary possibilities for using ACT to approach the care of persons with moral injury. Descriptions of moral injury and ACT are provided along with an overview of the developmental histories and relevant research literature in each of these domains. Specific possibilities for attending to moral injury are explored via examination of each of the six core processes in ACT: acceptance; cognitive defusion; contact with the present moment; self-as-context; values; and committed action. It is suggested that ACT has unique potential as an evidence-based psychotherapy for approaching numerous moral injury related issues. These include: understanding human suffering as normative, expectable, and potentially meaningful; balancing both verbal and experiential understandings of morality; fostering forgiveness in a manner that is not dismissive of guilt but employs it to orient towards values; holding and honoring morally injurious experiences in a way that respects and empathizes with ongoing suffering; identifying a sense of self from which to behaviorally enact valued actions; and inviting engagement from care providers and communities outside of the traditional mental health care system. Future conceptual and empirical work is needed, including studies examining the efficacy and effectiveness of ACT for moral injury.
Ocular Ultrasound as an Easy Applicable Tool for Detection of Terson's Syndrome after Aneurysmal Subarachnoid Hemorrhage

Introduction Intraocular hemorrhage in patients suffering from aneurysmal subarachnoid hemorrhage is known as Terson's syndrome and is an underestimated but common pathology. We therefore designed a prospective single-blinded study to evaluate the validity of ocular ultrasound compared to the gold standard indirect funduscopy in the diagnosis of Terson's syndrome. Material and Methods Fifty-two patients (104 eyes in total) suffering from aneurysmal subarachnoid hemorrhage were enrolled in this study. Two investigators independently performed a single-blinded ocular ultrasound using a standard intensive care ultrasound system to detect an intraocular hemorrhage. Indirect funduscopy following iatrogenic mydriasis served as the gold standard for confirmation or exclusion of an intraocular hemorrhage. Statistical analyses were performed to evaluate the sensitivity and specificity, positive and negative predictive values of the method as well as the learning curve of ocular ultrasound. Results Indirect funduscopy detected Terson's syndrome in 11 of 52 (21.2%) respectively in 21 of 104 (20.2%) eyes in patients suffering from subarachnoid hemorrhage. Sensitivity and specificity increased with the number of ocular ultrasound examinations for both investigators, reaching 81.8% and 100% respectively. Positive and negative predictive values were different for both investigators (63.6% vs. 100% positive and 100% vs. 95.7% negative) but were both correlated to the amount of intraocular hemorrhage. A low Glasgow Coma scale (p = 0.015) and high Hunt & Hess grade (p = 0.003) was associated with a higher rate of Terson's syndrome. Conclusions Ocular ultrasound using standard ultrasound equipment has been confirmed as a reliable, easy-to-handle bedside screening tool for detecting Terson's syndrome. Nevertheless funduscopy remains the gold standard to detect Terson's syndrome.
Why do academic scientists engage in interdisciplinary research

We introduce a measure of interdisciplinarity as the diversity of academic research production across scientific domains. Our dataset concerns more than 900 permanent researchers employed by a large French university which is ranked first among French universities in terms of impact. As expected we find that the traditional academic career incentives do not stimulate interdisciplinary research, while having connections with industry does. The context of work in the laboratory (size, colleagues' status, age and affiliations) strongly affects the propensity to undertake interdisciplinary research. Copyright , Beech Tree Publishing.
Default reasoning using maximum entropy and variable strength defaults

The thesis presents a computational model for reasoning with partial information which uses default rules or information about what normally happens. The idea is to provide a means of filling the gaps in an incomplete world view with the most plausible assumptions while allowing for the retraction of conclusions should they subsequently turn out to be incorrect. The model can be used both to reason from a given knowledge base of default rules, and to aid in the construction of such knowledge bases by allowing their designer to compare the consequences of his design with his own default assumptions. The conclusions supported by the proposed model are justified by the use of a probabilistic semantics for default rules in conjunction with the application of a rational means of inference from incomplete knowledge—the principle of maximum entropy (ME). The thesis develops both the theory and algorithms for the ME approach and argues that it should be considered as a general theory of default reasoning. The argument supporting the thesis has two main threads. Firstly, the ME approach is tested on the benchmark examples required of nonmonotonic behaviour, and it is found to handle them appropriately. Moreover, these patterns of commonsense reasoning emerge as consequences of the chosen semantics rather than being design features. It is argued that this makes the ME approach more objective, and its conclusions more justifiable, than other default systems. Secondly, the ME approach is compared with two existing systems: the lexicographic approach (LEX) and system Z. It is shown that the former can be equated with ME under suitable conditions making it strictly less expressive, while the latter is too crude to perform the subtle resolution of default conflict which the ME approach allows. Finally, a program called DRS is described which implements all systems discussed in the thesis and provides a tool for testing their behaviours.
Self-Models and Relationship Threat

This study investigated a key claim of risk regulation theory, namely, that psychological internalizing of a relationship threat will serve as a mediator of the link between self-models (self-esteem and attachment anxiety) and relationship responses (moving closer to a partner vs. distancing from a partner). Participants (N = 101) received feedback that threatened their current romantic relationship (or no feedback) and then completed measures of internal–external focus, relationship closeness–distancing, and acceptance–rejection of the feedback. Results showed that participants with negative self-models responded to the relationship threat by becoming more internally focused and by distancing from their partners, whereas those with positive self-models became more externally focused and moved closer to their partners. Mediation analyses indicated that the link between self-models and relationship closeness–distancing was partially explained by internal focus.
Mechanism of Self-Sterility in a Hermaphroditic Chordate

Hermaphroditic organisms avoid inbreeding by a system of self-incompatibility (SI). A primitive chordate (ascidian) Ciona intestinalis is an example of such an organism, but the molecular mechanism underlying its SI system is not known. Here, we show that the SI system is governed by two gene loci that act cooperatively. Each locus contains a tightly linked pair of polycystin 1–related receptor (s-Themis) and fibrinogen-like ligand (v-Themis) genes, the latter of which is located in the first intron of s-Themis but transcribed in the opposite direction. These genes may encode male- and female-side self-recognition molecules. The SI system of C. intestinalis has a similar framework to that of flowering plants but utilizing different molecules.