Miracle-dz/UniFAR-FTUs huggingface dataset:
Outbreak of Legionnaires' disease associated with a display whirlpool spa.

BACKGROUND Recognized outbreaks of Legionnaires' disease (LD) are rare; when they occur, they provide opportunities to understand the epidemiology of the illness and improve prevention strategies. We investigated a population-based outbreak. METHODS After the confirmation of LD in October 1996 in five people in neighbouring towns in southwest Virginia, active surveillance for additional cases was undertaken. A case-control study was conducted to identify exposures associated with illness, followed by a cohort study among employees of the facility at which the source of the outbreak was located in order to assess unrecognized exposure and illness. Samples of likely sources of LD in the facility were cultured for LEGIONELLA: RESULTS In all, 23 laboratory-confirmed cases of LD were eventually identified. Of the 15 cases in the case-control study, 14 (93%) reported visiting a home-improvement store, compared with 12 (27%) of 45 controls (matched odds ratio [MOR] = 23.3; 95% CI : 3-182). Among home-improvement centre patrons, 10 (77%) of 13 cases questioned recalled either visiting or walking by a display whirlpool spa, compared with 3 (25%) of 12 controls (MOR = 5.5; 95% CI : 0.7-256.0). Two cases' sputum isolates were an exact match, by monoclonal antibody subtyping and arbitrarily primed polymerase chain reaction, to a whirlpool spa filter isolate from the store. Employees reporting more exposure to the display spas were more likely to report symptoms of LD or to have an elevated titre. CONCLUSIONS This investigation shows that LD can be transmitted from a whirlpool spa used for display only, and highlights the need for minimizing the risk of transmission of LD from all water-filled spas. Key messages This paper describes an investigation of a population-based outbreak of Legionnaires' disease (LD). A case-control study first identified a home-improvement store as the likely source of the outbreak. An environmental investigation later confirmed that finding, as two cases' sputum isolates were an exact match, by monoclonal antibody subtyping and arbitrarily primed polymerase chain reaction, to a whirlpool spa filter isolate from the store. The spa was intended and used for display only.
: An Empirical Study

— This paper investigates the relative role of security standards, professional security certifications and technological tools in the protection of organizational data. Findings from the content analysis of 100 job postings for information security analysts and managers show that in general, organizations give more importance to knowledge validated by relevant professional certifications and to the working knowledge of IT products and solutions for the management of their information security than to the knowledge of a particular security standard. Details for such findings and their implications for research and practice are discussed.
A generalized temporal role based access control model for developing secure systems

A key issue in computer system security is to protect information against unauthorized access. Emerging workflow-based applications in healthcare, manufacturing, the financial sector, and e-commerce inherently have complex, time-based access control requirements. To address the diverse security needs of these applications, a Role Based Access Control (RBAC) approach can be used as a viable alternative to traditional discretionary and mandatory access control approaches. The key features of RBAC include policy neutrality, support for least privilege, and efficient access control management. However, existing RBAC approaches do not address the growing need for supporting time-based access control requirements for these applications. This research presents a Generalized Temporal Role Based Access Control (GTRBAC) model that combines the key features of the RBAC model with a powerful temporal framework. The proposed GTRBAC model allows specification of a comprehensive set of time-based access control policies, including temporal constraints on role enabling, user-role and role-permission assignments, and role activations. The model provides an event-based mechanism for supporting dynamic access control policies, which are crucial for developing secure workflow-based enterprise applications. In addition, the temporal hierarchies and separation of duty constraints facilitated by GTRBAC allow the development of security policies for commercial enterprises. The thesis provides various design guidelines for managing complexity and building secure systems based on this model. X-GTRBAC, an XML-based policy language has been developed to allow specification of GTRBAC policies.
Joint training of front-end and back-end deep neural networks for robust speech recognition

Based on the recently proposed speech pre-processing front-end with deep neural networks (DNNs), we first investigate different feature mapping directly from noisy speech via DNN for robust speech recognition. Next, we propose to jointly train a single DNN for both feature mapping and acoustic modeling. In the end, we show that the word error rate (WER) of the jointly trained system could be significantly reduced by the fusion of multiple DNN pre-processing systems which implies that features obtained from different domains of the DNN-enhanced speech signals are strongly complementary. Testing on the Aurora4 noisy speech recognition task our best system with multi-condition training can achieves an average WER of 10.3%, yielding a relative reduction of 16.3% over our previous DNN pre-processing only system with a WER of 12.3%. To the best of our knowledge, this represents the best published result on the Aurora4 task without using any adaptation techniques.
Unspoken Barriers: An Autoethnographic Study of Frustration, Resistance and Resilience

Immigration, cultural capital, cultural hybridity are the contributing players within my autoethnographic research as a second-generation daughter of southern Italian migrants from the post war era. This autobiography of my lived experience identifies contributing influences of arrested development within my educational and life trajectory and explores theoretical frameworks as key comparative indicators for my thwarted stages of psychosocial development. My identity and role as a female is further explored within the construct of a determined and culturally hybrid adolescence in an effort to answer research questions of identity and role confusion. My narratives situate my life as a daughter, student, and future wife living an existence of cultural hegemony acknowledging the non-existence of a bicultural relationship between my family and the Australian way.
Functional Synergy between Cholecystokinin Receptors CCKAR and CCKBR in Mammalian Brain Development

Cholecystokinin (CCK), a peptide hormone and one of the most abundant neuropeptides in vertebrate brain, mediates its actions via two G-protein coupled receptors, CCKAR and CCKBR, respectively active in peripheral organs and the central nervous system. Here, we demonstrate that the CCK receptors have a dynamic and largely reciprocal expression in embryonic and postnatal brain. Using compound homozygous mutant mice lacking the activity of both CCK receptors, we uncover their additive, functionally synergistic effects in brain development and demonstrate that CCK receptor loss leads to abnormalities of cortical development, including defects in the formation of the midline and corpus callosum, and cortical interneuron migration. Using comparative transcriptome analysis of embryonic neocortex, we define the molecular mechanisms underlying these defects. Thus we demonstrate a developmental, hitherto unappreciated, role of the two CCK receptors in mammalian neocortical development.
Eugenics and Modernization in Interwar Romania

When writing can change your life, when writing can enrich you by offering much money, why don't you try it? Are you still very confused of where getting the ideas? Do you still have no idea with what you are going to write? Now, you will need reading. A good writer is a good reader at once. You can define how you write depending on what books to read. This eugenics and modernization in interwar romania can help you to solve the problem. It can be one of the right sources to develop your writing skill.
Robust Adaptive Segmentation of 3D Medical Images with Level Sets

This paper is concerned with the use of the Level Set formalism to segment anatomical structures in 3D medical images (ultrasound or magnetic resonance images). A closed 3D surface propagates towards the desired boundaries through the iterative evolution of a 4D implicit function. The major contribution of this work is the design of a robust evolution model based on adaptive parameters depending on the data. First the step size and the external propagation force factor, both usually predetermined constants, are automatically computed at each iteration. Additionally, region-based information, rather than spatial image gradient, is exploited by estimating intensity probability density functions over the image. As a result, the method can be applied to various kinds of data. Quantitative and qualitative results on brain MR images and 3D echographies of carotid arteries are reported and discussed.
Exact Optimization for Markov Random Fields with Convex Priors

We introduce a method to solve exactly a first order Markov random field optimization problem in more generality than was previously possible. The MRF has a prior term that is convex in terms of a linearly ordered label set. The method maps the problem into a minimum-cut problem for a directed graph, for which a globally optimal solution can be found in polynomial time. The convexity of the prior function in the energy is shown to be necessary and sufficient for the applicability of the method.
Tracking of Fluid-Advected Odor Plumes: Strategies Inspired by Insect Orientation to Pheromone

Autonomous vehicles with plume-tracing capabilities would be valuable for finding chemical sources in fluid flows. This article considers strategies allowing autonomous vehicles to find and trace an odor plume to its source. These strategies are inspired by the maneuvers of moths flying upwind along a pheromone plume. Although moth maneuvers are well documented, the mechanisms underlying sensory perception and navigation are not fully understood; therefore, a key objective was to define sensor, signal-processing, and actuation algorithms for autonomous vehicles. The strategies presented do not precisely mimic insect orientation to odors. Optimizing performance, however, suggests orientation strategies that may have biological counterparts. The results demonstrate the importance of cross-plume counterturning strategies for maintaining intermittent contact with the chemical plume, given noisy sensory information. It is important for the searcher to maintain intermittent contact with the plume because flow direction while detecting odor is the main indicator of the instantaneous desired direction of motion.
The Diagnostic Value of the Correlation between Serum Anti-p53 Antibody and Positron Emission Tomography Parameters in Lung Cancer

Objective: Mutations in the p53 gene are the most commonly observed genetic abnormalities in malignancies. The purpose of this study was to assess the diagnostic value of serum anti-p53 antibody (Ab) along with the correlation between serum anti-p53 Ab level and quantitative positron emission tomography (PET) parameters such as maximum standardized uptake value (SUVmax), SUVave, metabolic tumor volume, total lesion glycolysis (TLG) and tumor size. Methods: Serum anti-p53 Ab level was studied in three groups. Patients who underwent 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging for staging of previously diagnosed lung cancer constituted the first group, while patients who underwent 18F-FDG PET/CT imaging for evaluation of suspicious pulmonary nodules detected on thorax CT and did not show pathologic FDG accumulation (NAPN=pulmonary nodule with non avid-FDG) were enrolled in the second group. The third group consisted of healthy volunteers. Results: Twenty-eight patients with lung cancer (median age: 62.5, range: 39-77years), 28 patients with NAPN (median age: 65, range: 33-79 years), and 24 healthy volunteers (median age: 62, range: 44-74 years) were enrolled in the study. The serum anti-p53 Ab level was low in healthy volunteers while it was higher in both lung cancer patients and NAPN patients (p<0.05). When serum anti-p53 Ab level and PET parameters were evaluated, there was no significant correlation between serum anti-p53 Ab level and SUVmax, SUVave, TLG, tumor volume and tumor size of patients with lung cancer (p>0.05). Besides, there was no significant difference between serum anti-p53 Ab level and lesion size of NAPN patients (p>0.05). Conclusion: It was determined that serum anti-p53 Ab levels are not significantly correlated with PET parameters, and that serum anti-p53 Ab levels increase in any benign or malignant lung parenchyma pathology as compared to healthy volunteers. These results indicate that this Ab cannot be used as a predictor of malignancy in a lung lesion.
Levosimendan Versus Dobutamine in Myocardial Injury Patients with Septic Shock: A Randomized Controlled Trial

Background We aimed to investigate the effect of levosimendan on biomarkers of myocardial injury and systemic hemodynamics in patients with septic shock. Material/Methods After achieving normovolemia and a mean arterial pressure of at least 65 mmHg, 38 septic shock patients with low cardiac output (left ventricular ejective fraction), LEVF ≤45%) were randomly divided into two groups: levosimendan dobutamine. Patients in the levosimendan and dobutamine groups were maintained with intravenous infusion of levosimendan (0.2 μg/kg/minute) and dobutamine (5 μg/kg/minute) for 24 hours respectively. During treatment we monitored hemodynamics and LVEF, and measured levels of heart-type fatty acid binding protein (HFABP), troponin I (TNI), and brain natriuretic peptide(BNP). In addition, the length of mechanical ventilation, intensive care unit (ICU) stay, hospital stay, and 28-day mortality were compared between the two groups. Results The levosimendan group and the dobutamine group were well matched with respect to age (years, 55.4±1 7.5 versus 50.2±13.6) and gender (males, 68.4% versus 57.9%). Levosimendan-treated patients had higher stroke volume index (SVI), cardiac index (CI), LVEF, and left ventricular stroke work index (LVSWI), and lower extravascular lung water index (EVLWI) compared to dobutamine-treated patients (p<0.05). HFABP, TNI, and BNP in the levosimendan group were less than in the dobutamine group (p<0.05). There was no difference in the mechanical ventilation time, length of stay in ICU and hospital, and 28-day mortality between the two groups. Conclusions Compared with dobutamine, levosimendan reduces biomarkers of myocardial injury and improves systemic hemodynamics in patients with septic shock. However, it does not reduce the days on mechanical ventilation, length of stay in ICU and hospital, or 28-day mortality.
Dual EGFR inhibition in combination with anti-VEGF treatment: A phase I clinical trial in non-small cell lung cancer

BACKGROUND Preclinical data indicate EGFR signals through both kinase-dependent and independent pathways and that combining a small-molecule EGFR inhibitor, EGFR antibody, and/or anti-angiogenic agent is synergistic in animal models. METHODS We conducted a dose-escalation, phase I study combining erlotinib, cetuximab, and bevacizumab. The subset of patients with non-small cell lung cancer (NSCLC) was analyzed for safety and response. RESULTS Thirty-four patients with NSCLC (median four prior therapies) received treatment on a range of dose levels. The most common treatment-related grade ≥2 adverse events were rash (n=14, 41%), hypomagnesemia (n=9, 27%), and fatigue (n=5, 15%). Seven patients (21%) achieved stable disease (SD) ≥6 months, two achieved a partial response (PR) (6%), and two achieved an unconfirmed partial response (uPR) (6%) (total=32%). We observed SD≥6 months/PR/uPR in patients who had received prior erlotinib and/or bevacizumab, those with brain metastases, smokers, and patients treated at lower dose levels. Five of 16 patients (31%) with wild-type EGFR experienced SD≥6 months or uPR. Correlation between grade of rash and rate of SD≥6 months/PR was observed (p<0.01). CONCLUSION The combination of erlotinib, cetuximab, and bevacizumab was well-tolerated and demonstrated antitumor activity in heavily pretreated patients with NSCLC.
Student Preferences for Academic Advisors as Transformational Leaders.

Student Preferences for Academic Advisors as Transformational Leaders. (December 2010) Deborah Suzanne Drozd, B.S., Texas A&M University; MEd., Texas A&M University Co-Chairs of Advisory Committee: Dr. Christine D. Townsend Dr. Barry Boyd A quantitative study was conducted to determine the preferences of undergraduate students for academic advisors as transformational leaders. A questionnaire was developed and distributed to undergraduate students enrolled in leadership classes at a major land grant university to determine importance ratings based on the variables including non-traditional and traditional students’ ages, classification, gender, number of times advised, number of visits to an academic advisor, membership in a collegiate military organization and athletics, and current leadership activities. Results indicated that undergraduate students preferred their academic advisors to use transformational leadership activities. There was no significant difference in the degree of preference of transformational leadership in their academic advisor based on gender, participation in athletics, traditional and non-traditional ages, classification, membership in a military organization and participation in a leadership position or number of times advised. However, inadequate representation of all groups within the number of times
Amerisclerosis?: The Puzzle of Rising U.S. Unemployment Persistence

The persistence of U.S. unemployment has risen with each of the last three recessions, raising the specter that future U.S. recessions might look more like the “Eurosclerosis” experience of the 1980s than like the traditional V-shaped recoveries of the past. We revisit several explanations for this rising persistence, decomposing them into three possible sources: business cycle fluctuations, changing policy responses, and propagation mechanisms. First, we find that financial shocks do not systematically lead to more persistent unemployment than monetary policy shocks, casting doubt on the hypothesis that different drivers of business cycles are the primary explanation. Second, we find that changing monetary and fiscal policy responses account for approximately one-third of the rise in unemployment persistence. Third, after examining three propagation mechanisms we find that jointly they cannot account for any rising persistence of unemployment. The three propagation mechanisms we focus on—declining labor mobility, changing age structures, and the decline in trust among Americans—are consistent with four other cyclical patterns that have evolved since the early 1980s: a rising cyclicality in long-term unemployment, lower regional convergence after downturns, rising cyclicality in disability claims, and missing disinflation. We exploit regional variation in labor market outcomes across Western Europe and North America during 1970–91 to assess the predictive capacity of each propagation mechanism for unemployment persistence. In summary, two-thirds of the rise in unemployment persistence is unexplained.
Do Your Online Friends Make You Pay ? A Randomized Field Experiment in an Online Music Social Network

Demonstrating compelling causal evidence of the existence and strength of peer to peer influence has become the holy grail of the modern research in online social networks. In these networks, it has been consistently demonstrated that user characteristics and behavior tend to cluster both in space and in time. There are two well known rival mechanisms that compete to be the explanation for this observed clustering: peer influence and homophily. Both mechanisms lead to similar observational data, yet have tremendously different policy implications. In this paper, we present a novel randomized experiment that tests the existence of causal peer influence in the general population of a particular large-scale online social network and quantifies its strength as compared to homophily. We utilize a unique social feature to exogenously induce adoption of a paid product amongst a group of randomly selected users, and in the process develop truly exogenous randomization of treatment and control groups. Our estimates show that peer influence causes 50% increase in odds of buying the product due to the influence coming from an adopting friend. In addition, we find that users with smaller number of friends are significantly more susceptible to be influenced by their peers as compared to the ones with larger number of friends. Finally, our experimental apparatus allows us to compare our randomized trial with a matching-based quasi-experiment. We find that the quasi-experiment tends to produce the results similar to randomized trial, but over-estimating the effect on users with larger number of friends and under-estimating it for the users with smaller number of friends, thus providing the first insights about the nature of bias in estimating peer-effects by the models with self-selected populations.
Music and Lyrics Interactions and their Influence on Recognition of Sung Words: An Investigation of Word Frequency, Rhyme, Metric Stress, Vocal Timbre, Melisma, and Repetition Priming

This study investigated several factors presumed to influence the intelligibility of song lyrics. Twenty-seven participants listened to recordings of musical passages sung in English; each passage consisted of a brief musical phrase sung by a solo voice. Six vocalists produced the corpus of sung phrases. Eight hypotheses derived from common phonological and prosodic principles were tested. Intelligibility of lyrics was degraded: (i) when archaic language was used; (ii) when words were set in melismatic rather than syllabic contexts; (iii) when the musical rhythm did not match the prosodic speech rhythm; and (iv) when successive target words rhymed. Intelligibility of lyrics was facilitated: (i) when words contained diphthongs rather than monophthongs; (ii) when a word from an immediately previous passage reappeared; (iii) when a syllabic setting of a word was preceded by a melismatic setting of the same word. No difference in word intelligibility was observed between music theater singers and opera singers.
P-Rex1 Cooperates with PDGFRβ to Drive Cellular Migration in 3D Microenvironments

Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers. In accordance with this proposed role in cancer cell invasion and metastasis, we find that ectopic expression of P-Rex1 in an immortalised human fibroblast cell line is sufficient to drive multiple migratory and invasive phenotypes. The invasive phenotype is greatly enhanced by the presence of a gradient of serum or platelet-derived growth factor, and is dependent upon the expression of functional PDGF receptor β. Consistently, the invasiveness of WM852 melanoma cells, which endogenously express P-Rex1 and PDGFRβ, is opposed by siRNA of either of these proteins. Furthermore, the current model of P-Rex1 activation is advanced through demonstration of P-Rex1 and PDGFRβ as components of the same macromolecular complex. These data suggest that P-Rex1 has an influence on physiological migratory processes, such as invasion of cancer cells, both through effects upon classical Rac1-driven motility and a novel association with RTK signalling complexes.