Miracle-dz/UniFAR-FTUs huggingface dataset:
Author ' s personal copy A neural predictor of cultural popularity

We use neuroimaging to predict cultural popularity — something that is popular in the broadest sense and appeals to a large number of individuals. Neuroeconomic research suggests that activity in reward-related regions of the brain, notably the orbitofrontal cortex and ventral striatum, is predictive of future purchasing decisions, but it is unknown whether the neural signals of a small group of individuals are predictive of the purchasing decisions of the population at large. For neuroimaging to be useful as a measure of widespread popularity, these neural responses would have to generalize to a much larger population that is not the direct subject of the brain imaging itself. Here, we test the possibility of using functional magnetic resonance imaging (fMRI) to predict the relative popularity of a common good: music. We used fMRI to measure the brain responses of a relatively small group of adolescents while listening to songs of largely unknown artists. As a measure of popularity, the sales of these songs were totaled for the three years following scanning, and brain responses were then correlated with these “future” earnings. Although subjective likability of the songs was not predictive of sales, activity within the ventral striatum was significantly correlated with the number of units sold. These results suggest that the neural responses to goods are not only predictive of purchase decisions for those individuals actually scanned, but such responses generalize to the population at large and may be used to predict cultural popularity. © 2011 Published by Elsevier Inc. on behalf of Society for Consumer Psychology.
New Strategies in Diagnosing Cancer in Thyroid Nodules: Impact of Molecular Markers

Thyroid cancer is the most common type of endocrine malignancy, with approximately 55,000 new cases diagnosed in the United States in 2012. However, thyroid nodules are much more prevalent, particularly with increased age, and only a small fraction of those are malignant. Therefore, the major clinical challenge is to reliably differentiate those nodules that are malignant and need to be treated surgically from the majority of nodules that are benign and do not require surgery. The traditional diagnostic approach to this clinical situation is ultrasound-guided fine-needle aspiration (FNA) of the thyroid nodule followed by cytologic examination, which together reliably establish the diagnosis in 70% to 80% of cases. However, in the rest of nodules the presence of cancer cannot be ruled out by FNA cytology, hampering appropriate surgical management and frequently resulting in unnecessary surgical interventions. New approaches to diagnosis of cancer in thyroid nodules are based on mutational and other molecular markers, which can be reliably detected in cells aspirated during the FNA procedure. These markers offer significant improvement in the diagnostic accuracy of FNA cytology and are poised to make a profound effect on the management of patients with thyroid nodules. In addition to the molecular markers that have recently become available for clinical use, rapid development of new sequencing techniques is expected to further improve the accuracy of cancer diagnosis in thyroid nodules and allow for a fully individualized approach to the management of patients with thyroid nodules. Clin Cancer Res; 19(9); 2283–8. ©2013 AACR.
Coverage Enhancing Algorithms in Directional Sensor Networks with Rotatable Sensors

Recently directional sensor networks have received a lot of attention. A directional sensor network is composed of many directional sensor nodes. Unlike conventional omni-directional sensors that always have an omni-angle of sensing range, directional sensors may have a limited angle of sensing range due to technical constraints, energy constraint or cost considerations. Area coverage problem is still an essential issue in directional sensor networks. In this paper, we study the area coverage problem in directional sensor networks. The problem is to maximize the area coverage of a randomly deployed directional sensor network. Each directional sensor can through rotating orientation to get better coverage in an interested region. We therefore propose two greedy algorithms to enhance the area coverage. Simulation results show that our proposed algorithms outperform the previous proposed method in term of the area coverage.
The effects of motivation feedback in patients with severe mental illness: a cluster randomized controlled trial

Objective To evaluate the effectiveness of providing clinicians with regular feedback on the patient’s motivation for treatment in increasing treatment engagement in patients with severe mental illness. Methods Design: cluster randomized controlled trial (Dutch Trials Registry NTR2968). Participants: adult outpatients with a primary diagnosis of a psychotic disorder or a personality disorder and their clinicians, treated in 12 community mental health teams (the clusters) of two mental health institutions in the Netherlands. Interventions: monthly motivation feedback (MF) generated by clinicians additional to treatment as usual (TAU) and TAU by the community mental health teams. Primary outcome: treatment engagement at patient level, assessed at 12 months by clinicians. Randomization: teams were allocated to MF or TAU by a computerized randomization program that randomized each team to a single treatment by blocks of varying size. All participants within these teams received similar treatment. Clinicians and patients were not blind to treatment allocation at the 12-month assessment. Results The 294 randomized patients (148 MF, 146 TAU) and 57 clinicians (29 MF, 28 TAU) of 12 teams (6 MF, 6 TAU) were analyzed according to the intention-to-treat principle. No statistically significant differences between treatment groups on treatment engagement were found (adjusted mean difference =0.1, 95% confidence interval =−2.2 to 2.3, P=0.96, d=0). Preplanned ancillary analyses showed statistically significant interaction effects between treatment group and primary diagnosis on treatment motivation and quality of life (secondary outcomes), which were beneficial for patients with a primary diagnosis of a personality disorder but not for those with a psychotic disorder. There were no reports of adverse events. Conclusion The current findings imply that monitoring and discussing the patient’s motivation is insufficient to improve motivation and treatment engagement, and suggests that more elaborate interventions for severe mental illness patients are needed.
Nonequilibrium fluctuations in small systems: From physics to biology

In this paper I am presenting an overview on several topics related to nonequilibrium fluctuations in small systems. I start with a general discussion about fluctuation theorems and applications to physical examples extracted from physics and biology: a bead in an optical trap and single molecule force experiments. Next I present a general discussion on path thermodynamics and consider distributions of work/heat fluctuations as large deviation functions. Then I address the topic of glassy dynamics from the perspective of nonequilibrium fluctuations due to small cooperatively rearranging regions. Finally, I conclude with a brief digression on future perspectives.
The Role of HuR in the Post-Transcriptional Regulation of Interleukin-3 in T Cells

Human Interleukin-3 (IL-3) is a lymphokine member of a class of transiently expressed mRNAs harboring Adenosine/Uridine-Rich Elements (ARE) in their 3' untranslated regions (3'-UTRs). The regulatory effects of AREs are often mediated by specific ARE-binding proteins (ARE-BPs). In this report, we show that the human IL-3 3'-UTR plays a post-transcriptional regulation role in two human transformed cell lines. More specifically, we demonstrate that the hIL-3 3'-UTR represses the translation of a luciferase reporter both in HeLa and Jurkat T-cells. These results also revealed that the hIL-3 3'-UTR-mediated translational repression is exerted by an 83 nt region comprised mainly by AREs and some non-ARE sequences. Moreover, electrophoretic mobility shift assays (EMSAs) and UV-crosslinking analysis show that this hIL-3 ARE-rich region recruits five specific protein complexes, including the ARE-BPs HuR and TIA-1. HuR binding to this ARE-rich region appears to be spatially modulated during T-cell activation. Together, these results suggest that HuR recognizes the ARE-rich region and plays a role in the IL-3 3'-UTR-mediated post-transcriptional control in T-cells.
Blood Pressure and Penumbral Sustenance in Stroke from Large Vessel Occlusion

The global burden of stroke remains high, and of the various subtypes of stroke, large vessel occlusions (LVOs) account for the largest proportion of stroke-related death and disability. Several randomized controlled trials in 2015 changed the landscape of stroke care worldwide, with endovascular thrombectomy (ET) now the standard of care for all eligible patients. With the proven success of this therapy, there is a renewed focus on penumbral sustenance. In this review, we describe the ischemic penumbra, collateral circulation, autoregulation, and imaging assessment of the penumbra. Blood pressure goals in acute stroke remain controversial, and we review the current data and suggest an approach for induced hypertension in the acute treatment of patients with LVOs. Finally, in addition to reperfusion and enhanced perfusion, efforts focused on developing therapeutic targets that afford neuroprotection and augment neural repair will gain increasing importance. ET has revolutionized stroke care, and future emphasis will be placed on promoting penumbral sustenance, which will increase patient eligibility for this highly effective therapy and reduce overall stroke-related death and disability.
Relationship between mandibular cortical bone height and bone mineral density of lumbar spine.

UNLABELLED The aim of this study was to evaluate the association between lumbar spine bone mineral density and mandible cortical bone height at the mental foramen and at the angle of the jaw. PATIENTS AND METHODS A total of 130 women living in Lithuania, were examined. None of the participants were known to have endocrine, metabolic or skeletal disorders. Bone mineral density (BMD) was measured in the spine lumbar area L2-L4. The mandibles were examined on panoramic x-ray images. On each radiograph cortical thickness of mandible was measured at the mental foramen and at the angle of the jaw. The results demonstrated a tendency of high probability of osteoporosis in cases were radiomorphometric parameters are low. There was a significant difference between bone mineral density of lumbar spine and cortical bone height of mandible below the foramen mentale and at the angle of the jaw (p<0.01).
Personality-dependent dispersal cancelled under predation risk

Dispersal is a fundamental life-history trait for many ecological processes. Recent studies suggest that dispersers, in comparison to residents, display various phenotypic specializations increasing their dispersal inclination or success. Among them, dispersers are believed to be consistently more bold, exploratory, asocial or aggressive than residents. These links between behavioural types and dispersal should vary with the cause of dispersal. However, with the exception of one study, personality-dependent dispersal has not been studied in contrasting environments. Here, we used mosquitofish (Gambusia affinis) to test whether personality-dependent dispersal varies with predation risk, a factor that should induce boldness or sociability-dependent dispersal. Corroborating previous studies, we found that dispersing mosquitofish are less social than non-dispersing fish when there was no predation risk. However, personality-dependent dispersal is negated under predation risk, dispersers having similar personality types to residents. Our results suggest that adaptive dispersal decisions could commonly depend on interactions between phenotypes and ecological contexts.
Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles

Interstitial cells of Cajal (ICC) generate pacemaker activity (slow waves) in gastrointestinal (GI) smooth muscles, but the mechanism(s) of pacemaker activity are controversial. Several conductances, such as Ca2+‐activated Cl− channels (CaCC) and non‐selective cation channels (NSCC) have been suggested to be involved in slow wave depolarization. We investigated the expression and function of a new class of CaCC, anoctamin 1 (ANO1), encoded by Tmem16a, which was discovered to be highly expressed in ICC in a microarray screen. GI muscles express splice variants of the Tmem16a transcript in addition to other paralogues of the Tmem16a family. ANO1 protein is expressed abundantly and specifically in ICC in all regions of the murine, non‐human primate (Macaca fascicularis) and human GI tracts. CaCC blocking drugs, niflumic acid and 4,4′‐diisothiocyano‐2,2′‐stillbene‐disulfonic acid (DIDS) reduced the frequency and blocked slow waves in murine, primate, human small intestine and stomach in a concentration‐dependent manner. Unitary potentials, small stochastic membrane depolarizations thought to underlie slow waves, were insensitive to CaCC blockers. Slow waves failed to develop by birth in mice homozygous for a null allele of Tmem16a (Tmem16atm1Bdh/tm1Bdh) and did not develop subsequent to birth in organ culture, as in wildtype and heterozygous muscles. Loss of function of ANO1 did not inhibit the development of ICC networks that appeared structurally normal as indicated by Kit antibodies. These data demonstrate the fundamental role of ANO1 in the generation of slow waves in GI ICC.
A nonlinear unsupervised adaptation technique for speech recognition

This paper describes a computationally inexpensive, nonlinear feature transformation technique for rapid adaptation of a speech recognition system to new acoustic conditions. One of the advantages of the method is that it does not require any initial decoding of the adaptation data for computing the nonlinear transform. This technique performs as well as the more expensive unsupervised MLLR technique. Further-more, it signi(cid:12)cantly adds to the improvement when combined with unsupervised MLLR.
The Development of Symbolic Coordination: Representation of Imagined Objects, Executive Function, and Theory of Mind

Children's developing competence with symbolic representations was assessed in 3 studies. Study 1 examined the hypothesis that the production of imaginary symbolic objects in pantomime requires the simultaneous coordination of the dual representations of a dynamic action and a symbolic object. We explored this coordination of symbolic representations in 3- to 5-year-olds with a modified action pantomime task that employed both a "dynamic action + object" condition and a "hold + object" condition. Consistent with earlier research, production of imaginary symbolic objects rather than body-part-as-objects increased with age, although, even at age 5, children did not perform at adult levels. As hypothesized, children produced fewer body-part-as-object anchors when they were simply asked to hold an object, rather than perform a dynamic action with the object. Study 2 repeated the conditions of Study 1 and examined these conditions in relation to performance on the Dimensional Change Card Sort (DCCS) task. This study replicated the developmental findings of the earlier study and indicated a modest relation between pantomime and the DCCS, which disappeared with age partialled out. Study 3 examined the action pantomime task in relation to the DCCS, false belief, and appearance-reality with 3- to 5-year-olds. Though performance on the DCCS was related to theory of mind, production of imaginary symbolic objects in pantomime was not strongly related to theory of mind or the DCCS. Results are discussed in terms of children's developing reflective competence in coordinating symbolic representations.
Confounding Extremities: Surgery at the Medico-Ethical Limits of Self-Modification

This article discusses the debate over apotemnophilia and its diagnosis and treatment, focusing on the bioethical, legal, and cultural implications of elective amputation as a possible therapy. The author argues that the sensationalism surrounding apotemnophilia should not be allowed to deter the thoughtful interdisciplinary inquiry that is appropriate to this debate, which raises important questions about the definition of bodily integrity, the process of medical standard-setting, and the limits of physician and patient autonomy when it comes to surgical modification of the body.
Spatial resolution of atrial pace mapping as determined by unipolar atrial pacing at adjacent sites.

BACKGROUND The purpose of this study was to examine the spatial resolution of unipolar atrial pace mapping by pacing at adjacent sites within the coronary sinus and the right atrium. METHODS AND RESULTS Unipolar pacing from each pole of a quadripolar catheter was performed in the coronary sinus (n = 29) and in the right atrium (n = 10). Pacing from the distal electrode was used to simulate the site of origin of an atrial tachycardia. These P waves were compared with the P waves generated by unipolar pacing from each of the three proximal electrodes. The P waves were analyzed for changes in amplitude, duration, and configuration. Pacing within the coronary sinus resulted in significant changes in amplitude and duration at distances of 17 and 21 mm from the distal pole, respectively. Similarly, pacing in the right atrium resulted in significant changes in amplitude and duration at distances of 17 and 32 mm from the distal pole, respectively. No significant changes in configuration were noted in the coronary sinus in any lead at packing sites < or = 32 mm from the distal pole. Configurational changes were noted in the right atrium at pacing sites 17 mm from the distal pole. CONCLUSIONS The spatial resolution of unipolar atrial pace mapping is approximately 17 mm. These findings indicate that mapping techniques that depend on the accurate discrimination of P-wave morphology, such as pace mapping or concealed entertainment, are likely to be imprecise when used in the atria.
Superconductivity and antiferromagnetism in quasi-one-dimensional organic conductors (Review Article)

We review the current understanding of superconductivity in the quasi-one-dimensional organic conductors of the Bechgaard and Fabre salt families. We discuss the interplay between superconductivity, antiferromagnetism, and charge-density-wave fluctuations. The connection to recent experimental observations supporting unconventional pairing and the possibility of a triplet spin order parameter for the superconducting phase is also presented.
Dependent interferer arrangement for physical layer security: Secrecy outage probability in clustered wireless networks

Secure communication is expected to be achieved by locating interfering transmitters near a transmitter sending confidential messages. This is because the transmitters in this arrangement would cause harmful interference to eavesdroppers. To investigate this proposal, this paper theoretically analyzes the secrecy outage probability (SOP) in clustered wireless networks. The SOP is formulated on the basis of the stochastic geometry approach, considering the case when the transmitters are distributed according to a Neyman-Scott cluster process. Numerical results reveal the impact of various clustered distributions of transmitters on the SOP. In addition, this paper conducts a comparative evaluation of the SOP between the clustered distribution and a uniform random distribution. It is revealed that the clustered distribution, in particular consisting of small size clusters and a large number of transmitters in each cluster, can reduce SOP compared to the uniform random distribution.
Data analysis in Raman measurements of biological tissues using wavelet techniques

Raman spectroscopy of oral tissues is a promising tool for in vivo diagnosis of oral pathologies, due to the high chemical and structural information content of Raman spectra. However, measurements on biological tissues are usually hindered by low level signals and by the presence of interfering noise and background components due to light diffusion or fluorescence processes. Numerical methods can be used in data analysis, in order to overcome these problems. In this work the wavelet multicomponent decomposition approach has been tested in a series of micro-Raman measurements performed on “in vitro” animal tissue samples. The experimental set-up was mainly composed by a He-Ne laser and a monochromator equipped with a liquid nitrogen cooled CCD equipped with a grating of 1800 grooves/mm. The laser light was focused on the sample surface by means of a 50 X optical objective. The resulting spectra were analysed using a wavelet software package and the contribution of different vibration modes have been singled out. In particular, the C=C stretching mode, and the CH2 bending mode of amide I and amide III and tyrosine contributions were present. The validity of wavelet approach in the data treatment has been also successfully tested on aspirin.
Online Variance Reduction for Stochastic Optimization

Modern stochastic optimization methods often rely on uniform sampling which is agnostic to the underlying characteristics of the data. This might degrade the convergence by yielding estimates that suffer from a high variance. A possible remedy is to employ non-uniform importance sampling techniques, which take the structure of the dataset into account. In this work, we investigate a recently proposed setting which poses variance reduction as an online optimization problem with bandit feedback. We devise a novel and efficient algorithm for this setting that finds a sequence of importance sampling distributions competitive with the best fixed distribution in hindsight, the first result of this kind. While we present our method for sampling datapoints, it naturally extends to selecting coordinates or even blocks of thereof. Empirical validations underline the benefits of our method in several settings.
MISALIGNMENT OF OUTFLOW AXES IN THE PROTO-MULTIPLE SYSTEMS IN PERSEUS

We investigate the alignment between outflow axes in nine of the youngest binary/multiple systems in the Perseus Molecular Cloud. These systems have typical member spacing larger than 1000 au. For outflow identification, we use 12CO(2-1) and 12CO(3-2) data from a large survey with the Submillimeter Array: Mass Assembly of Stellar Systems and their Evolution with the SMA. The distribution of outflow orientations in the binary pairs is consistent with random or preferentially anti-aligned distributions, demonstrating that these outflows are misaligned. This result suggests that these systems are possibly formed in environments where the distribution of angular momentum is complex and disordered, and these systems do not come from the same co-rotating structures or from an initial cloud with aligned vectors of angular momentum.
Use of the heteroduplex mobility assay and cell sorting to select genome sequences of the CCR5 gene in HEK 293T cells edited by transcription activator-like effector nucleases

Engineered nucleases such as zinc finger nucleases (ZFN) and transcription activator-like effector nucleases (TALEN) are one of the most promising tools for modifying genomes. These site-specific enzymes cause double-strand breaks that allow gene disruption or gene insertion, thereby facilitating genetic manipulation. The major problem associated with this approach is the labor-intensive procedures required to screen and confirm the cellular modification by nucleases. In this work, we produced a TALEN that targets the human CCR5 gene and developed a heteroduplex mobility assay for HEK 293T cells to select positive colonies for sequencing. This approach provides a useful tool for the quick detection and easy assessment of nuclease activity.