Miracle-dz/UniFAR-FTUs huggingface dataset:
Dyadic perfectionism, communication patterns and relationship quality in couples

Maladaptive dyadic perfectionism and couples’ negative communication patterns, particularly demand-withdraw and mutual avoidance-withholding patterns of communication, are among various factors that are associated with poor relationship quality. Individuals high in maladaptive dyadic perfectionism are inclined to believe that their romantic partner’s performance always falls short of their high ideal expectations. Informed by Robins and Boldero’s (2003) relational discrepancy theory, this study was designed to assess three primary questions: (a) How does maladaptive dyadic perfectionism relate to perceived relationship quality for both partners? ; (b) How does maladaptive dyadic perfectionism relate to negative communication patterns between romantic partners? ; and (c) Do negative communication patterns between partners mediate the association between maladaptive dyadic perfectionism and perceived relationship quality? Both partners in 113 heterosexual, monogamous, long-term romantic relationships were recruited from community resources and from the Psychology Department Participant Pool at the University of Windsor. All participants completed measures to assess dyadic perfectionism, communication patterns, relationship quality and other relationship variables. Structural Equation Modeling was used to assess hypotheses. Actor-Partner Interdependence Model (APIM) analyses indicated that actor but not partner effects were supported for men and women; maladaptive dyadic perfectionism in one partner was associated with their own perceptions of relationship quality, but not with their partner’s perceptions of relationship quality. APIM analyses indicated that actor and partner effects between maladaptive dyadic perfectionism and communication were significant, with the exception of the partner effect between
Beyond Socioeconomics: Explaining Ethnic Group Differences in Parenting Through Cultural and Immigration Processes

This study examined both socioeconomic and cultural factors in explaining ethnic differences in monitoring, behavioral control, and warmth—part of a series of coordinated studies presented in this special issue. Socioeconomic variables included mother's and father's educational levels, employment status, home ownership, number of siblings in the household, and single parent status. Cultural factors included nationality or ethnicity, immigrant status of child, mother's/father's age of arrival in the United States, mother's/father's English language use with the child, child's native fluency, and cultural values for independence and interdependence. The sample consisted of 591 European American, 123 African American, 1,614 Asian American, and 597 Latino students in the ninth grade. All the ethnic minority groups were higher than European Americans on behavioral control, and Latinos were also higher than European Americans on monitoring. However, European Americans were higher on parental warmth than Asian Americans and African Americans. These ethnic group differences primarily remained even after controlling for the socioeconomic factors. Finally, in analyses looking within the Asian and Latino groups, differences in parenting were found within both groups due to nationality or ethnicity, youth's fluency in the native language, and cultural values of interdependence, although values of independence were also related to the parenting of Asian Americans.
Sequence types and plasmid carriage of uropathogenic Escherichia coli devoid of phenotypically detectable resistance.

OBJECTIVES Plasmids play a major role in the dissemination of antibiotic resistance, and several studies have shown the association between specific resistance mechanisms and certain plasmid types and/or Escherichia coli lineages. This study describes the distribution of plasmids, replicon types, sequence types (STs) and ST complexes (STCs) of E. coli devoid of phenotypic resistance to 24 antibiotics. METHODS Eighty E. coli isolates from urinary tract infections from four European countries were selected because of their lack of phenotypically detectable antibiotic resistance. The isolates were characterized to the phylogenetic group level using PCR and to ST by multilocus sequence typing. Plasmid carriage was assessed using S1 nuclease PFGE profiling and PCR-based replicon typing. RESULTS Plasmids were detected in only 38/80 (47%) of the isolates; one (n = 18), two (n = 14), three (n = 5) and four (n = 1) plasmids. Six different replicon types were identified, the most common being a combination of IncFII and IncFIB. Most isolates belonged to phylogenetic group B2 and STC73 (n = 20), STC95 (n = 7) and ST420 (n = 6). A high proportion of STC73 isolates (75%) was devoid of plasmids. No association could be found between specific STs and replicon type. CONCLUSIONS A large proportion of E. coli strains phenotypically devoid of antibiotic resistance were plasmid naive. Those isolates that harboured plasmids displayed replicon types similar to those of resistant isolates, but the distributions of STs and STCs were different. This may indicate chromosomally encoded mechanisms important for the stabilization of plasmids harbouring antibiotic resistance.
Targeted next generation sequencing of endoscopic ultrasound acquired cytology from ampullary and pancreatic adenocarcinoma has the potential to aid patient stratification for optimal therapy selection

Background & Aims Less than 10% of registered drug intervention trials for pancreatic ductal adenocarcinoma (PDAC) include a biomarker stratification strategy. The ability to identify distinct mutation subsets via endoscopic ultrasound fine needle aspiration (EUS FNA) molecular cytology could greatly aid clinical trial patient stratification and offer predictive markers. We identified chemotherapy treatment naïve ampullary adenocarcinoma and PDAC patients who underwent EUS FNA to assess multigene mutational frequency and diversity with a surgical resection concordance assessment, where available. Methods Following strict cytology smear screening criteria, targeted next generation sequencing (NGS) using a 160 cancer gene panel was performed. Results Complete sequencing was achieved in 29 patients, whereby 83 pathogenic alterations were identified in 21 genes. Cytology genotyping revealed that the majority of mutations were identified in KRAS (93%), TP53 (72%), SMAD4 (31%), and GNAS (10%). There was 100% concordance for the following pathogenic alterations: KRAS, TP53, SMAD4, KMT2D, NOTCH2, MSH2, RB1, SMARCA4, PPP2R1A, PIK3R1, SCL7A8, ATM, and FANCD2. Absolute multigene mutational concordance was 83%. Incremental cytology smear mutations in GRIN2A, GATA3 and KDM6A were identified despite re-examination of raw sequence reads in the corresponding resection specimens. Conclusions EUS FNA cytology genotyping using a 160 cancer gene NGS panel revealed a broad spectrum of pathogenic alterations. The fidelity of cytology genotyping to that of paired surgical resection specimens suggests that EUS FNA represents a suitable surrogate and may complement the conventional stratification criteria in decision making for therapies and may guide future biomarker driven therapeutic development.
Unemployment as a risk factor for AIDS and death for HIV-infected patients in the era of highly active antiretroviral therapy

Objectives: To assess the association between social situation and disease progression among patients diagnosed with HIV infection since the advent of highly active antiretroviral therapy (HAART), taking late testing into account. Methods: Prospective cohort study of adults diagnosed with HIV since 1996 in six large HIV reference centres in France. Associations between social situation and death, disease progression and treatment initiation were assessed using Cox regression model. Analysis was restricted to 5302 patients (77.9% of the sample) for whom the status at HIV diagnosis (late or not late) was known. Results: 134 people (2.5%) died and 400 presented with a new AIDS defining event (7.5%). In multivariate analysis, probabilities of death (HR 3.75, 95% CI 2.11 to 6.66) and disease progression (HR 1.59, 95% CI 1.17 to 2.15) were higher for non-working patients and for late testers (HR 9.18, 95% CI 4.32 to 19.48 for death) and lower for treated patients (HR 0.18, 95% CI 0.08 to 0.41 for death and HR 0.29, 95% CI 0.20 to 0.42 for disease progression). The probability of receiving antiretroviral treatment was not associated with employment status but was higher for late testers, for those living in a stable relationship and lower for those diagnosed after 2000. Conclusion: Among patients diagnosed for HIV infection in the HAART era, poor social situation is an independent risk factor of mortality and morbidity, and is not explained by delayed access to diagnosis or treatment.
Metamaterial-based efficient electrically small antennas

A metamaterial paradigm for achieving an efficient, electrically small antenna is introduced. Spherical shells of ho- mogenous, isotropic negative permittivity (ENG) material are designed to create electrically small resonant systems for several antennas: an infinitesimal electric dipole, a very short center-fed cylindrical electric dipole, and a very short coaxially-fed electric monopole over an infinite ground plane. Analytical and numerical models demonstrate that a properly designed ENG shell provides a distributed inductive element resonantly matched to these highly capacitive electrically small antennas, i.e., an ENG shell can be designed to produce an electrically small system with a zero input reactance and an input resistance that is matched to a specified source resistance leading to overall efficiencies approaching unity. Losses and dispersion characteristics of the ENG materials are also included in the analytical models. Finite element numerical models of the various antenna-ENG shell systems are developed and used to predict their input impedances. These electrically small antenna-ENG shell systems with idealized dispersionless ENG material properties are shown to be very efficient and to have fractional bandwidths above the values associated with the Chu limit for the quality factor without any degradation in the radiation patterns of the antennas. Introducing dispersion and losses into the analytical models, the resulting bandwidths are shown to be reduced significantly, but remain slightly above (below) the corresponding Chu-based value for an energy-based limiting (Drude) dispersion model of the permittivity of the ENG shell.
Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease.

BACKGROUND Endothelial cells release endothelium-derived relaxing factor (EDRF) in a variety of vascular beds, including the pulmonary circulation. However, the role of EDRF-mediated pulmonary-artery relaxation in chronic hypoxic lung disease is unknown. METHODS We studied endothelium-dependent relaxation mediated by EDRF in vitro in pulmonary arteries that had been obtained from 22 patients undergoing heart-lung transplantation for end-stage chronic obstructive lung disease. Control pulmonary arteries were obtained from 15 patients undergoing lobectomy for lung carcinoma who did not have evidence of other chronic lung disease. The responses of all vascular rings (external diameter, 1.2 to 3.4 mm) to the endothelium-dependent vasodilators acetylcholine and adenosine diphosphate were studied immediately after lung excision. RESULTS Pulmonary arterial rings from the patients with chronic lung disease developed a greater tension (2.19 +/- 0.16 g) in response to phenylephrine (10(-6) M) than the rings from control patients (1.28 +/- 0.18 g, P less than 0.05). Inhibition of EDRF synthesis by treatment with NG-monomethyl-L-arginine (10(-4) M) eliminated this difference, increasing the tension in the rings from the controls (P less than 0.01) but not in those from the patients with chronic lung disease. Rings from control patients relaxed in response to cumulative doses (10(-10) to 10(-5) M) of acetylcholine (maximal relaxation, 81.3 +/- 3.9 percent) and adenosine diphosphate (maximal relaxation, 85.3 +/- 2.6 percent). By contrast, rings from patients with chronic obstructive lung disease achieved only 41.3 +/- 4.8 percent of maximal relaxation in response to acetylcholine (n = 32) and 49.4 +/- 5.5 percent in response to adenosine diphosphate (n = 24) (P less than 0.001, as compared with control rings). Rings from both the controls and the patients with chronic lung disease relaxed similarly in response to the endothelium-independent vasodilator sodium nitroprusside (10(-4) M). There was an inverse correlation between the degree of intimal thickening and the level of maximal relaxation of the rings from the patients with chronic lung disease (r = -0.60, P less than 0.001). Maximal relaxation was also related directly to the partial pressure of arterial oxygen before transplantation (r = 0.68, P less than 0.01) and inversely to the partial pressure of arterial carbon dioxide before transplantation (r = -0.55, P less than 0.01), but not to the forced expiratory volume in one second (r = 0.19, P not significant). CONCLUSIONS Endothelium-dependent pulmonary-artery relaxation in vitro is impaired in arteries from patients with end-stage chronic obstructive lung disease. Such impairment may contribute to the development of pulmonary hypertension in chronic hypoxic lung disease.
Development of a combination drug-eluting bead: towards enhanced efficacy for locoregional tumour therapies

Drug-eluting beads (DEBs) are becoming a mainstay locoregional therapy for hepatic malignancies but are currently loaded with single drugs alone. Here, we wished to prepare DEB containing different drug combinations, to screen their efficacy using an in-vitro cell culture assay and to include any promising combinations that demonstrate additive efficacy in an in-vivo model of locoregional tumour treatment. A modified in-vitro assay was used based upon the use of 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) with either HepG2 liver cancer or PSN1 pancreatic cancer cell lines. The comparative cytotoxicity of DEB combinations prepared containing doxorubicin, irinotecan, topotecan and rapamycin was evaluated. Those combinations that demonstrated an additive cytotoxicity effect were investigated in vivo using a nude mouse xenograft model of pancreatic cancer. Although many of the DEB combinations showed either no effect or a slight antagonistic effect, the combination of doxorubicin and rapamycin DEBs demonstrated synergistic activity. On the basis of these findings, a method was developed to prepare a doxorubicin/rapamycin dual-loaded DEB, which was shown to possess the same drug-loading capacities, drug elution properties and HepG2 cell cytotoxicity synergy as the single drug-loaded DEB combination. Evaluation of this dual-loaded combination DEB versus the respective single drug-loaded DEBs in a mouse xenograft model of pancreatic cancer showed an equivalent tumour volume reduction as the doxorubicin DEB, but with less toxicity than the rapamycin DEB. The doxorubicin/rapamycin combination DEB offers great potential for enhanced efficacy in the locoregional treatment of malignant tumours.
Dreams, visions, and values in fundamental business education

Purpose – The purpose of this paper is to explore the concept of a pedagogy of aspiration – a focus on dreams, visions, and values in fundamental business education. The paper focusses on issues of motivation and creativity in a global and multi-cultural milieu. Business education is often viewed as fundamentally about rational and analytical thinking, but creativity and innovation are also central. Due to information technology and globalization, they may be even more fundamental to business success than ever before. Both educators and managers can benefit from thinking about creativity and innovation in this context, since both are responding to the same business trends, and developing the same people. Design/methodology/approach – Since business fundamentals should reflect business realities, global trends in information and communications technology and mass migration brought on by information and communications technology are explored, and their relevance to the imagination and creativity is develope.
Whistleblowing in Audit Firms: Organizational Response and Power Distance

ABSTRACT: This paper investigates auditors' likelihood to report observations of colleagues' unethical behavior. We consider whether two characteristics that are particularly relevant to the audit environment, prior organizational response and power distance, affect willingness to report. Data collected from 106 senior-level auditors suggest auditors are more likely to report on their peers than on their superiors, but they are more likely to report superiors when prior organizational response is strong than when it is weak. Additionally, men appear to be relatively less sensitive to variations in power distance or prior organization response than women. Moral intensity of the case is significantly related to reporting likelihood, and power distance moderates this effect such that those who perceive this scenario to be of lower moral intensity are much more influenced by power distance than are those who perceive it to be of high moral intensity. These results contribute to the existing literature on acco.
RAISING BILINGUAL-BILITERATE CHILDREN IN MONOLINGUAL CULTURES

RAISING BILINGUAL-BILITERATE CHILDREN IN MONOLINGUAL CULTURES. Stephen J. Caldas. Clevedon, UK: Multilingual Matters, 2006. Pp. xvi + 231. $39.95 paper. Caldas's work tells the story of his three children's language development over the course of 19 years. Caldas is a native English speaker from Louisiana and a fluent but nonnative speaker of French. Caldas's wife hails from Quebec and is a native French speaker, also fluent in English. Their three children—a boy and twin girls who were born 2 years later—were raised in suburban Louisiana with extended French-immersion vacations in Quebec. Caldas and his wife attempt to make their home a French-only environment by adopting a family language policy of speaking only French themselves and by promoting French-language books, television, and media. Whereas they are successful throughout the children's early years, their project meets resistance when their eldest boy reaches about 10 and begins to reject everything French. The younger girls soon follow in his footsteps. With patience, perseverance, and regular extended visits to French-speaking Quebec, this phase passes, and by the volume's happy ending, all three children become bilingual and biliterate teens (and presumably adults).
"She's Always Been the Smart One. I've Always Been the Dumb One": Identities in the Mathematics Classroom

The moment-to-moment dynamics of student discourse plays a large role in students' enacted mathematics identities. Discourse analysis was used to describe meaningful discursive patterns in the interactions of 2 students in a 7th-grade, technology-based, curricular unit (SimCalc MathWorlds®) and to show how mathematics identities are enacted at the microlevel. Frameworks were theoretically and empirically connected to identity to characterize the participants' relative positioning and the structural patterns in their discourse (e.g., who talks, who initiates sequences, whose ideas are taken up and publicly recognized). Data indicated that students' peer-to-peer discourse patterns explained the enactment of differing mathematics identities within the same local context. Thus, the ways people talk and interact are powerful influences on who they are, and can become, with respect to mathematics.
The association between sleep patterns and overweight/obesity in Chinese children: a cross-sectional study

Objective This study evaluated the association between sleep patterns and the risk of being overweight/obese in Chinese children. Methods A total of 3,086 children (1,608 boys and 1,478 girls) between 7 and 14 years of age and studying in primary schools were recruited as eligible study participants in this study. We collected the information about children regarding sleep patterns, body height and weight, insomnia, healthy status, time allocation of daily activities, and demographic characteristics using a parental-reported questionnaire. Results Overweight/obese children were younger, predominantly male, and more prone to have suffered from illness in the past 12 months compared to normal-weight peers. They were also less prone to compensate for sleep deficits during weekends (47.6% vs 39.1%; χ2=11.637, P<0.001) and holidays (52.0% vs 42.0%; χ2=16.057, P<0.001). Sleep duration on weekdays did not affect the risk of being overweight/obese. The adjusted odds ratios for overweight/obesity (noncompensated) group using the compensated group as a reference were 1.197 (95% confidence interval [CI]: 1.004–1.493) during weekends and 1.309 (95% CI: 1.052–1.630) during holidays. Conclusion Compensation for sleep deficits on non-weekdays may ameliorate the risk of being overweight/obese in Chinese children. Moreover, no significant association between the risk of being overweight/obese and sleep duration on weekdays was demonstrated in the current study, which may be due to pervasive sleep insufficiency on weekdays in Chinese children.
Turning Real-World Software Development into a Game

Software development is a challenging, but seldom amusing activity. At the same time, gamification, a recent trend that brings game mechanics to websites and interactive media, together with many past works that propose the use of serious games to teach software engineering in a fun way, show evidence that this type of real-world activity can also incorporate game design elements. In this work, we propose a novel approach: incorporating game mechanics directly into a software development process, effectively turning it into a live game. We show interesting results from a case study with a production team of a software house, and firmly believe it is important that the game academic community spreads this type of knowledge to influence other research areas.
The Third-Person Effect in Communication

A person exposed to a persuasive communication in the mass media sees this as having a greater effect on others than on himself or herself. Each individual reasons: “I will not be influenced, but they (the third persons) may well be persuaded. ” In some cases, a communication leads to action   
Source of Phosphate in the Enzymic Reaction as a Point of Distinction among Aminoglycoside 2″-Phosphotransferases*

Aminoglycoside 2″-phosphotransferases are clinically important enzymes that cause high levels of resistance to aminoglycoside antibiotics by the organisms that harbor them. These enzymes phosphorylate aminoglycosides, and the modified antibiotics show significant reduction in the binding ability to target the bacterial ribosome. This report presents a detailed characterization of the antibiotic resistance profile and the aminoglycoside and nucleotide triphosphate substrate profiles of four common aminoglycoside 2″-phosphotransferases widely distributed in clinically important Gram-positive microorganisms. Although the antibiotic resistance phenotypes exhibited by these enzymes are similar, their aminoglycoside and nucleotide triphosphate substrate profiles are distinctive. Contrary to the dogma that these enzymes use ATP as the source of phosphate in their reactions, two of the four aminoglycoside 2′-phosphotransferases utilize GTP as the phosphate donor. Of the other two enzymes, one exhibits preference for ATP, and the other can utilize either ATP or GTP as nucleotide triphosphate substrate. A new nomenclature for these enzymes is put forth that takes into account the differences among these enzymes based on their respective substrate preferences. These nucleotide triphosphate preferences should have ramifications for understanding of the evolution, selection, and dissemination of the genes for these important resistance enzymes.