Miracle-dz/UniFAR-FTUs huggingface dataset:
Rough set-based neuro-fuzzy system

This paper presents a novel hybrid intelligent system which synergizes the concept of knowledge reduction in rough set theory with the human-like reasoning style of fuzzy systems and the learning and connectionist structure of neural networks. The proposed rough set-based neuro-fuzzy system (RNFS) incorporates a wrapper-based feature selection method that employs the mutual information maximization scheme which selects attributes with high relevance and the concept of knowledge reduction in rough set theory which selects attributes with low redundancy. Experimental results show that the proposed RNFS utilizes less computational effort and yielded promising results on feature selection as well as classification accuracy.
Treatment Noncompliance with Orally Disintegrating Olanzapine Tablets

Case Report Mr A, age 16 years, is a slow-to-warm-up high-school student from a middle socioeconomic background. He presented for the first time to the clinic with a 21⁄2-year history of school refusal and irritability. On clarification, it was apparent that from a very young age (even before age 5 years) he was excessively concerned about dirt. He would avoid looking at the toilet, even while using it, take an abnormally long time washing his face (his clothes getting wet in the process) and bathing, and would not allow anyone to use his towels. He would also avoid using toilets outside his own house whenever he went on a trip. About 21⁄2 years before presenting to the clinic, he also began to have obsessive images of a dirty bathroom and toilet. Further, he began to fear that he would forget lessons studied and, hence, fail to answer either in class or during examinations. Consequently, he avoided exams and refused to go to school. He also thought that people were talking about him on the road and had checking compulsions yielding to these obsessive doubts, fears that books given to friends might get lost, compulsive reassurance seeking, repeated intrusive ruminations about events during the day, and thoughts that he would be responsible for something bad happening. He was also found to have a history suggesting separation anxiety disorder of childhood, sibling rivalry, and oppositional tendencies, for which psychiatric consultation had not been sought. The family history suggested unspecified mental illness in his maternal grand-aunt and maternal uncle, possible depressive illness in his paternal great-grandmother, and subclinical obsessive–compulsive symptoms in his mother’s maternal uncle. Although he had poor insight and was uncooperative for treatment at the time of presentation, he started showing response to sertraline (up to 150 mg daily). Later, he started cooperat ing with exposureand response-prevention therapy for his contaminat ion obsessions and with audioexposure therapy for his obsessive fear of forgetting lessons learned. At the end of 4 weeks’ inpatient treatment, his obsessions and compulsions showed significant improvement.
Significance of Myocardial aand / 5-Adrenoceptors in Catecholamine-Induced Cardiac Hypertrophy

The role of aand /9-adrenoceptors in the development of catecholamine-induced cardiac hypertrophy in vivo was investigated. Rats received a constant intravenous infusion of norepinephrine or sodium chloride (control) for 3 days. The norepinephrine infusion was combined with the a-blocker prazosin, the 0-blocker metoprolol, or both blockers. For modulation of the work load of the heart, the calcium channel blocker verapamil was added to the norepinephrine infusion. A further group of animals was treated with the a-adrenergic stimulator norfenephrine, which also was combined with prazosin or verapamil. Norepinephrine induced significant increases in mean aortic pressure, left ventricular dP/dt^, heart rate, and total peripheral resistance. The left ventricular weight/body weight ratio was significantly elevated and was accompanied by an increase in the RNA concentration and the RNA/DNA ratio. Prazosin as well as metoprolol partially antagonized the increase in left ventricular weight and RNA concentration, whereas simultaneous prazosin and metoprolol treatment prevented the norepinephrine-induced alterations. Although combination of norepinephrine with verapamil resulted in considerable reduction of all functional parameters, the development of cardiac hypertrophy and the elevated RNA/DNA ratio were not significantly influenced. Stimulation of or-receptors with norfenephrine elicited an increase in total peripheral resistance and in left ventricular weight, which was abolished by prazosin. Verapamil did not affect the norfenephrine-induced cardiac hypertrophy, although it normalized essentially all functional parameters. Thus, the rapid development of cardiac hypertrophy in the norepinephrine model seems to be directly mediated by stimulation of myocardial aand /J-adrenoceptors rather than by hemodynamic changes. (Circulation Research 1989;65:1417-1425)
SURGICAL OUTCOMES ACCORDING TO VITREOUS MANAGEMENT AFTER SCLERAL FIXATION OF POSTERIOR CHAMBER INTRAOCULAR LENSES

Purpose: To investigate the effect of vitreous management on surgical outcomes after scleral fixation of posterior chamber intraocular lenses. Methods: The medical records of 83 eyes from 83 patients, who underwent scleral fixation of posterior chamber intraocular lenses without any preexisting vitreoretinal complication and were followed up for ≥6 months, were reviewed retrospectively. Subjects were divided according to the strategy used for vitreous management into a pars plana vitrectomy (PPV) group (47 eyes) and an anterior vitrectomy (AV) group (36 eyes). Surgical outcomes were compared between the groups. Results: Both groups were comparable regarding demographics, follow-up period, and underlying ocular disease. The degree of visual improvement was similar in both groups (P = 0.911). Postoperatively, each group developed a myopic shift, which was greater in the PPV group than in the AV group (P = 0.040). Intraocular pressure elevations ≥25 mmHg occurred in 50% of eyes in the AV group and in 11% of eyes in the PPV group (P < 0.001). Intraocular lenses dislocated more frequently in the AV group (28%) than in the PPV group (9%; P = 0.036). Intraocular lens capture was more common in the PPV group (23%) than in the AV group (3%; P = 0.010). There was no significant difference in the rate of postoperative vitreoretinal complications. Conclusion: In eyes that received scleral fixation of posterior chamber intraocular lenses, PPV decreased the chances of postoperative intraocular pressure elevation and intraocular lens dislocation but increased the likelihood of intraocular lens capture and the magnitude of postoperative myopic shift.
Equal mobility of gravel in streams: The remains of the day

The concept of equal mobility of gravel transport is 2 decades old. The weak form of the hypothesis states that in order to transport the coarse half of the mean annual gravel load through a river reach at a rate equal to the fine half, the coarser material must be overrepresented on the bed surface, giving rise to a mobile‐bed armor. The degree of mobile‐bed armoring necessary to accomplish this diminishes with increasing bed shear stress. The strong form of the hypothesis states that the grain size distribution of the gravel portion of the bed load should be similar to that of the substrate and finer than that of the surface layer. Here the hypothesis is subjected to a rigorous test in the laboratory under controlled conditions which are nevertheless chosen to be as representative as possible of actual field conditions. The grain size distributions used in the experiment included both model “gravel” and model “sand. ” At the end of the experiment the entire surface layer and a significant depth of substrate were removed from an entire reach of the channel and sieved. The results of the experiment confirmed the weak form of equal mobility: The surface layer was significantly coarsened compared with the bed load, even when the “sand” was excluded from the size distributions. The strong form of equal mobility was also supported by the experiment, in that the size distribution of the “gravel” substrate was nearly identical to the size distribution of the “gravel” portion of the load. The gravel substrate was, however, slightly but measurably coarser than the gravel load, a tendency that has been observed in the field in cases for which the strong form is not satisfied.
Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review

Forkhead box M1 (FOXM1), a member of the Fox transcription factors family, was closely related with cell cycle. FOXM1 played an important role in MST and prompted a poor prognosis for MST patients. However, there were also some studies revealing no significant association between the FOXM1 expression and prognosis of patients. Therefore, we conducted meta-analysis to investigate whether the expression of FOXM1 was associated with MST prognosis. We collected 36 relevant studies through PubMed database and obtained research data of 4946 patients. Stata 12.0 was used to express the results as hazard ratio (HR) for time-to-event outcomes with 95% confidence intervals (95% CI). It was shown that overexpression of FOXM1 was relevant to worse survival of MST patients (HR = 1.99, 95% CI = 1.79–2.21, P < 0.001; I 2 = 26.4%, P h = 0.076). Subgroup analysis suggested that overexpression of FOXM1 in breast cancer (BC), gastric cancer (GC), hepatocellular carcinoma (HCC), pancreatic ductal adenocarcinoma (PDA), and non-small-cell lung cancer (NSCLC) all predicted a worse survival (P < 0.05), in addition to ovarian cancer (OC) (P = 0.084). In conclusion, our research indicated that overexpression of FOXM1 was to the disadvantage of the prognosis for majority of MST and therefore can be used as an evaluation index of prognosis.
A real-time 17-scale object detection accelerator with adaptive 2000-stage classification in 65nm CMOS

This paper presents an object detection accelerator that features many-scale (17), many-object (up to 50), multi-class (e.g., face, traffic sign), and high accuracy (average precision of 0.79/0.65 for AFW/BTSD datasets). Employing 10 gradient/color channels, integral features are extracted, and the results of 2,000 simple classifiers for rigid boosted templates are adaptively combined to make a strong classification. By jointly optimizing the algorithm and the hardware architecture, the prototype chip implemented in 65nm CMOS demonstrates real-time object detection of 13–35 frames per second with low power consumption of 22–160mW at 0.58–1.0V supply.
When Sexism and Feminism Collide

The current study examined how feminism relates to women’s experiences of sexual harassment—that is, unwanted sexual and sexist conduct in the workplace. We posited that feminism would have both costs (e.g., increasing exposure to harassment) and benefits (e.g., decreasing harassment-related outcomes). We assessed two indicators of feminism: self-identification as “feminist” and engagement in feminist activism. We also measured two subtypes of sexual harassment: sexual-advance and gender harassment. According to survey data from 424 working women, feminist identification predicted fewer gender harassment experiences; once harassed, however, feminist-identified women reported the greatest decrease in job satisfaction and increase in turnover intentions. In contrast, feminist activism related to greater experiences of both kinds of harassment, and activism attenuated some negative outcomes. We further found that (regardless of feminist identification or activism) women who had faced sexual-advance harassment were over 7 times more likely to attach the “sexual harassment” label to their experiences, compared to women who had experienced gender harassment alone. In light of our findings, we recommend that sexual harassment laws, policies, and trainings be broadened to encompass all varieties of sexual harassment, including non-stereotypical, non-sexual conduct. Organizations would also benefit from interventions that reduce bias against undervalued persons, including feminists.
Why have studies of tailored anti-platelet therapy failed so far?

Summary Published data linking clopidogrel non-responsiveness to adverse ischaemic events lead to the suggestion that the magnitude of platelet inhibition by clopidogrel can be monitored and individually adjusted. This has been tested in randomised clinical trials (ARCTIC, GRAVITAS and TRIGGER-PCI), but despite reducing platelet reactivity, a strategy of therapy adjustment based on platelet function monitoring did not reduce the incidence of cardiac ischaemic events. Several critical issues regarding the design of these trials, which might in part have led to negative results, are discussed in this article.
Monetary Policy and Exchange Rate Volatility in a Small Open Economy

We lay out a small open economy version of the Calvo sticky price model, and show how the equilibrium dynamics can be reduced to simple representation in domestic inflation and the output gap. We use the resulting framework to analyze the macroeconomic implications of three alternative rule-based policy regimes for the small open economy: domestic inflation and CPI-based Taylor rules, and an exchange rate peg. We show that a key difference among these regimes lies in the relative amount of exchange rate volatility that they entail. We also discuss a special case for which domestic inflation targeting constitutes the optimal policy, and where a simple second order approximation to the utility of the representative consumer can be derived and used to evaluate the welfare losses associated with the suboptimal rules.
MYCORRHIZAL COMMUNITY DYNAMICS FOLLOWING NITROGEN FERTILIZATION: A CROSS‐SITE TEST IN FIVE GRASSLANDS

Arbuscular mycorrhizal fungi (AMF) are considered both ecologically and physiologically important to many plant communities. As a result, any alteration in AMF community structure following soil nitrogen (N) enrichment may impact plant community function and contribute to widespread changes in grassland productivity. We evaluated the responses of AMF communities to N fertilization (≥100 kg N·ha−1·yr−1) in five perennial grasslands within the Long-Term Ecological Research network to generate a broader understanding of the drivers contributing to AMF species richness and diversity with increasing soil N fertility, and subsequent effects to host-plant communities. AMF spore and hyphal community data at three mesic sites (Cedar Creek, Kellogg Biological Station, Konza Prairie) and two semiarid sites (Sevilleta, Shortgrass Steppe) were collected over two consecutive years and used to test four hypotheses about AMF responses to N fertilization. Under ambient soil N, plant annual net primary productivity and soi.
The role of 18F-FDG PET/CT imaging in patient with malignant PEComa treated with mTOR inhibitor

Malignant perivascular epithelioid cell tumor (malignant PEComa) is a rare disease for which the diagnostic criteria and treatment options have not been established. Since PEComa is associated with upregulation of mammalian target of rapamycin (mTOR) pathway which controls Glut-1 (glucose transporter) function, increased 18F-fluorodeoxyglucose (18F-FDG) uptake may indicate the over activation of mTOR pathway and may guide selectively inhibiting mTOR pathway treatment. We report a malignant PEComa patient who presented for 18F-FDG positron emission tomography/computed tomography (PET/CT) restaging. The tumor had shown significant avidity on PET/CT as well as an evident response to sirolimus (rapamycin, Rapamune™) that supports the utility of mTOR inhibitors as an effective treatment for malignant PEComa. Therefore, 18F-FDG PET/CT is helpful in restaging and guiding treatment for malignant PEComa with mTOR inhibitors.
Evaluation of urinary plasminogen activator, its receptor, matrix metalloproteinase-9, and von Willebrand factor in pancreatic cancer.

PURPOSE Pancreatic cancer remains a devastating problem with the majority of patients succumbing to death from this disease. A hallmark of pancreatic cancer is the loss of basement membrane that may be attributed to the action of urinary plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9). These enzymes are also implicated in angiogenesis. uPA and microvessel density have been shown to be good prognostic indicators for breast and colon cancer. MMP-9 and microvessel density have not been investigated in pancreatic cancer. We have therefore investigated by immunohistochemistry: (a) frequency of uPA expression and its receptor uPAR and the site of synthesis of uPA by in situ hybridization (ISH); (b) MMP-9 and its coexpression with uPA; (c) microvessel density as determined by von Willebrand factor staining and its relationship to uPA and MMP-9 expression; and (d) correlation of these parameters with survival. EXPERIMENTAL DESIGN Archival paraffin sections of 27 pancreatic tumors were semiquantitatively investigated by immunohistochemistry using the following antibodies: (a) monoclonal antibodies (MAbs) uPA(1) and uPA(2) (3689 and 394, respectively); (b) MAb uPAR, (no. 3932); (c) MAb MMP-9 (no. 936); and (d) rabbit anti-F8RA/vWF. ISH was performed using a uPA cDNA. RESULTS Both uPA antibodies revealed overexpression of uPA (93%) often with uniform staining of tumor cells. uPAR and MMP-9 showed focal staining in only 52 and 37% of tumors, respectively. Morphologically normal appearing ductal cells in close proximity to tumors overexpressed uPA in contrast to distally located normal cells (P = <0.001). uPA staining was also investigated in pancreatic intraepithelial neoplasia (PanIN) lesions. PanIN 1A/B staining for uPA was seen in 8 cases (30%), that for PanIN 2 in 19 cases (70%), and for PanIN3 in 12 cases (44%). Lumen of microvessels in the tumor stroma also revealed staining of uPA in 10 cases (37%). ISH experiments revealed the presence of uPA mRNA not only in the cytoplasm of tumor cells but also in adjacent normal appearing ducts as well as in PanIN lesions. Patients with overexpression of uPA, uPAR, or MMP-9 had a trend toward poorer survival than those who did not express it. Microvessel density did not show any significant relationship with uPA, uPAR, and MMP-9 expression and survival. CONCLUSIONS We conclude that uPA and MMP-9 are potential prognostic indicators in pancreatic cancer, whereas microvessel density may not be one. This study confirms our previous observation that uPA is made by the tumor cells themselves. Presence of uPA in vessels of tumor stroma suggests that uPA is in circulation, and its measurement and that of MMP-9 in the blood of these patients may aid in prognosis. Patients showing overexpression of uPA and MMP-9 have a trend toward shorter survival time.
Global Savannah Phenology : Integrating Earth Observation, Ecosystem Modeling, and PhenoCams

Savannahs are land areas where grass and trees co-exists to create a landscape that is neither a grassland nor a forest. It is estimated that savannahs cover approximately one sixth of the global land surface. They also play an important role in the global carbon cycle due to their total size. Most savannahs are characterized with two distinct seasons, one dry season and one wet season where a majority of rainfall and vegetation growth is occurring. This makes the seasonality in climate especially important since it controls the timing of growth by affecting for example leaf emergence and leaf fall. Those timing of growth are most often collectively termed vegetation phenology.Phenology is the science of observing and describing life cycles and events of plants or animals over time. Vegetation phenology has a long history and observations were probably used for the first time thousands of years ago to note down changes in vegetation and harvests. Nowadays we can represent vegetation phenology at different scales using many different techniques. It can, for example, be analyzed and estimated using earth observation, site level measurements, or ecosystem modelling. Earth observation, or remote sensing, is the science of obtaining information about an object or area from a distance. For phenology vegetation indices measured from satellites are normally used. They often take advantage of the fact that plants during photosynthesis absorb the light in specific wavelengths. Site level measurements are instead carried out on the ground to monitor the ecosystem properties at the site level. They typically consist of measurement of temperature, soil moisture, precipitation, and carbon fluxes. But they could also be expanded with PhenoCams which is term referring to a digital camera producing images of the vegetation at a regular interval. Finally, ecosystem models are a mathematical representation of the ecological system and are used to understand and predict the real system. However, there exists a knowledge gap regarding the precise mechanisms affecting the vegetation phenology on savannahs. The aim of this thesis was therefore to use all of the above mentioned fields to improve our understanding and ability to estimate savannah vegetation phenology. The main results showed that soil water is of great importance for estimation of savannah vegetation phenology. It further showed the potential of using remotely sensed soil moisture and PhenoCams to improve our estimates of savannah vegetation phenology. (Less)
Eigenvalue separation in some random matrix models

The eigenvalue density for members of the Gaussian orthogonal and unitary ensembles follows the Wigner semicircle law. If the Gaussian entries are all shifted by a constant amount s/(2N)1/2, where N is the size of the matrix, in the large N limit a single eigenvalue will separate from the support of the Wigner semicircle provided s>1. In this study, using an asymptotic analysis of the secular equation for the eigenvalue condition, we compare this effect to analogous effects occurring in general variance Wishart matrices and matrices from the shifted mean chiral ensemble. We undertake an analogous comparative study of eigenvalue separation properties when the sizes of the matrices are fixed and s→∞, and higher rank analogs of this setting. This is done using exact expressions for eigenvalue probability densities in terms of generalized hypergeometric functions and using the interpretation of the latter as a Green function in the Dyson Brownian motion model. For the shifted mean Gaussian unitary ensemble an.