Question: In what neighborhood of Upper Manhattan, New York City, does the Second Avenue Line of the New York City Subway border?
Sentence (from "East Harlem"): East Harlem, also known as Spanish Harlem or El Barrio, is a neighborhood of Upper Manhattan, New York City roughly encompassing the area north of the Upper East Side and East 96th Street up to about the 140s, east of Fifth Avenue to the East and Harlem Rivers.
Relevant evidence: Yes