Question: Who is the mother-in-law of Maria Manuela, Princess Of Portugal?
Sentence (from "Philip II of Spain"): The son of Holy Roman Emperor and King of the Spanish kingdoms Charles V and Isabella of Portugal, Philip was called "Felipe el PrudentePhilip the Prudent") in the Spanish kingdoms; his empire included territories on every continent then known to Europeans, including his namesake the Philippines.
Relevant evidence: Yes