Question: What U.S. senator held office from 2001 to 2009 and won by a two-to-one margin in their reelection? 
Sentence (from "United States Senate election in New York, 2006"): Incumbent Democratic U.S. Senator Hillary Rodham Clinton won, by a more than two-to-one margin, a second term representing New York in the United States Senate.
Relevant evidence: Yes