Question: Who is Pope Clement Vii's paternal grandmother?
Sentence (from "Pope Clement VII"): Inheriting daunting challenges, including Martin Luther’s Protestant Reformation in Northern Europe; a vast power struggle in Italy between Europe’s two most powerful kings, Holy Roman Emperor Charles V and Francis I of France, each of whom demanded that the Pope choose a side; and Turkish invasions of Eastern Europe led by Suleiman the Magnificent; Clement's problems were exacerbated by King Henry VIII of England’s contentious divorce, resulting in England breaking away from the Catholic Church; and in 1527, souring relations with Emperor Charles V leading to the violent Sack of Rome, during which the Pope was imprisoned.
Relevant evidence: No