Question: Who is Margaret Holles, Duchess Of Newcastle-Upon-Tyne's paternal grandmother?
Sentence (from "Margaret Holles, Duchess of Newcastle-upon-Tyne"): Her husband was created Duke of Newcastle in 1694, the first creation having become extinct in 1691 when her father died without a male heir (her only brother, Henry Cavendish, Earl of Ogle, died in 1680).
Relevant evidence: No