Question: In what direction does the U.S. highway that connects Florence, Souther Carolina and the county seat of Richland County run?
Sentence (from "Columbia, South Carolina"): It is the center of the Columbia metropolitan statistical area, which had a population of 767,598 as of the 2010 United States Census, growing to 817,488 by July 1, 2016, according to 2015 U.S. Census estimates.
Relevant evidence: No