Question: Which first setters was the place near an Interstate Highway that follows the U.S. Route 78 in Mississippi named for?
Sentence (from "Interstate 22"): Interstate 22 (I-22) is an Interstate Highway that follows the U.S. Route 78 (US 78) corridor on a 213 mi route from Byhalia, Mississippi south of Memphis, Tennessee, to Birmingham, Alabama.
Relevant evidence: Yes