Question: "Separation Anxiety" is the fifth season premiere of which American spy thriller drama television series,  and the 49th episode overall, that premiered on Showtime on October 4, 2015? 
Sentence (from "Thanks for the Memories (Grimm)"): The episode was written by series creators David Greenwalt and Jim Kouf and was directed by Norberto Barba.
Relevant evidence: No