human: Given a hyperedge-centered hypergraph: <hypergraph>, where the center hyperedge groups authors who co-authored the same paper.

Details of the hypergraph:
Center hyperedge (induced by source paper "Pairwise alignment incorporating dipeptide covariation"):
  Abstract: Motivation: Standard algorithms for pairwise protein sequence alignment make the simplifying assumption that amino acid substitutions at neighboring sites are uncorrelated. This assumption allows implementation of fast algorithms for pairwise sequence alignment, but it ignores information that could conceivably increase the power of remote homolog detection. We examine the validity of this assumption by constructing extended substitution matrices that encapsulate the observed correlations between neighboring sites, by developing an efficient and rigorous algorithm for pairwise protein sequence alignment that incorporates these local substitution correlations and by assessing the ability of this algorithm to detect remote homologies.

Results: Our analysis indicates that local correlations between substitutions are not strong on the average. Furthermore, incorporating local substitution correlations into pairwise alignment did not lead to a statistically significant improvement in remote homology detection. Therefore, the standard assumption that individual residues within protein sequences evolve independently of neighboring positions appears to be an efficient and appropriate approximation.

Availability: Sequence data, software and matrices are freely available from http://compbio.berkeley.edu/

Contact: gec@compbio.berkeley.edu

Supplementary information: Supplementary data for this paper is available at Bioinformatics online.

Includes members:
  Member "Statistical evaluation of pairwise protein sequence comparison with the Bayesian bootstrap":
    also connected through other hyperedges:
      (none)

Question: Please tell me which research area the co-authored paper (i.e., the source paper of the center hyperedge) belongs to. The 4 classes are: Computer science, Mathematics, Engineering, Economics, Psychology, Business. Directly output the class name.

gpt: Mathematics