definiens: means any Third Party that has a then - current contractual relationship with Isis pursuantto which ( i ) such Third Party is required to disclose to Isis on at least an annual basis any ManufacturingImprovements invented or developed by such Third Party, and ( ii ) Isis has the right to license such Third Party’sManufacturing Improvements to [COMPANY] under this Agreement and in accordance Section 9.3.2 ( Terms of SharingArrangement ), and ( iii ) such Third Party is either ( A ) [ * * ] or [ * * ], ( B ) manufacturing at least 50 % of its requirementsfor the active pharmaceutical ingredient for an ASO Product under license from Isis on its own behalf or through Isis(i.e ., it is not using a Third Party manufacturer to manufacture such portion of such active ingredient ) or(C ) maintaining an ongoing and substantial internal process development program related to the manufacture of ASOProducts