definiens: means : ( a ) ( a mammalian target that is upstream or downstream in the pathway of, or in a Related Pathway to, a mammalian orthologue of a Selected Target or Disclosed Target ], which orthologue was identified by or on behalf of [COMPANY] purs.uant to work under the Mode of Action Program [ or by or on behalf of [COMPANY] or its Affiliate or sublicensee through the material use of such Selected Target or Disclosed Target or any DNA sequence infonnation relating thereto, or any other Research Results that Remain Confidential at the time of such use, and provided further, that such mammalian target was identified by or on behalf of [COMPANY] or its Affiliate or sublicensee through the material use of such orthologue to such Selected Target or Disclosed Target, the DNA or protein sequence of such orthologue, or any other Infonnation II : : z CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS . IS FILED WITH nIE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF nIE SECURITIES ACT OF 1933, AS AMENDED