definiens: means all uses or applications of a Compound, where the Compound is applied inside the lumen of the Alimentary Canal for the Treatment of a Condition of the Alimentary Canal or local manifestation within the Alimentary Canal of a systemic Condition, where the Alimentary Canal means the passage along which food passes for digestion, also known as the gastrointestinal tract . The Alimentary Canal begins immediately behind the lips and ends at the anus . It includes the mouth ( including all mucosal tissues in the oral cavity, the gums, the teeth, the tongue and the salivary glands ), throat, esophagus, stomach, small intestine and large intestine . For the avoidance of doubt, the Alimentary Canal does not include the urinary tract . For the avoidance of doubt, Alimentary Local Therapy includes oral administration of a Compound where the Therapeutic effect does not substantially depend on systemic absorption, or administration through the use of suppositories and enemas