definiens: , with correlative meanings or to, means covalent chemicalbonding of any poly ( ethylene glycol ) reagent ( including the REAGENT and including covalent chemical bonding throughlinking groups ) with or to another material or materials . Such materials include, without limitation, proteins, peptides, oligonucleotides, other biomolecules, small molecules, therapeutic agents ( including the THERAPEUTIC AGENT),diagnostic agents, imaging agents and detectable labels . Additional materials that may be PEGYLATED include withoutlimitation, polymers, liposomes, films, chemical separation and purification surfaces, solid supports, metal / metal oxidesurfaces and other surfaces such as, by way of example but not limitation, those on implanted devices, and equipment, where apoly ( ethylene glycol ) reagent ( including the REAGENT ) is covalently chemically bonded to one or more reactive moleculeson the surface of such device or equipment . shall include the synthesis, derivatization, characterization, andmodification of PEG for such purposes, together with the synthesis, derivatization, characterization, and modification of theraw materials and intermediates for the manufacture of poly ( ethylene glycol ) reagents ( including the REAGENT ) or products(including the PRODUCT ) incorporating such poly ( ethylene glycol ) reagent by means of covalent chemical bonding, and allmethods of making and using each and all of the foregoing