definiens: means Manufacturer ’s total cost of manufacturing, supplying, storing, procuring, and/or shipping a particular batch or other amount of Supplied Compound supplied hereunder ( as defined inManufacturer ’s reasonable accounting policies consistently applied, including but not limited to costs of permitted ThirdParty Page 4 of 60EXECUTION COPY contractors or materials ) . Notwithstanding anything to the contrary, however, Fully - Burdened Manufacturing Costs shall notinclude any ( i ) value added taxes, sales taxes, use taxes, or other taxes ( other than income taxes ), duties, tariffs, customscharges, or similar amounts imposed with the respect to Manufacturer ’s purchase, sale, transfer, import, or export of SuppliedCompound or ( ii ) shipping, handling, transportation, or insurance charges associated with the delivery or shipment ofSupplied Compound as required hereunder, provided that the foregoing shall not in any event be construed to limit anyobligation under this Agreement to pay or reimburse Cempra for any of the foregoing