definiens: shall mean ( i ) all U.S. pa tent applications claiming any inventions or discoveries conceived and reduced to practice in th e course of the Research Program by Symyx or TDCC o r jointly by Symyx and TDCC, or conceived by Symyx be fore the Research Program and reduced to practice i n the Research Program, which claim an Agreement Comp ound or a Product, or method or process for the manufacture of an Agreement Compound or Product, or a composition - of - matter containing an Agreement Compound or Product, or a method or process for the use of an Agreement Compound in or for the manufac ture of a Product, in each case that are necessary or ma terially useful for the manufacture, use or sale of Agreement Compounds or Products in the Field, ( ii ) all divisi ons, substitutions, continuations, continuation - in- part applications, and reissues, re - examinations and ext ensions of ( i ) above, ( iii ) foreign counterparts of any of the preceding of ( i ) or ( ii ) above, and ( iv ) patents, u tility models or similar grants of rights issuing o n any of the preceding of ( i ), ( ii ) or ( iii ) above . It is unders tood and agreed that Program Patents shall not incl ude any Combinatorial Chemistry Technology or results of In dependent TDCC Research