definiens: means the Licensed Patent Prop erty, and the patents and patent applications set f orth in Exhibit 1 ( which shall be updated from time to time by Licen sor ), all other patents and patent applications tha t are directed to the Compound or its manufacture or use and in which Licensor holds rights, including, without limititation, those patents and patent applications that are directed to Licensor ’s interest in Improv ements, and any and all patents in which Licensor holds rights and that may issue from any of the foregoing patent applications, including any and all divisions, cont inuations, continuations - in - part, extensions, subst itutions, renewals, registrations, supplementary protection c ertificates, revalidations, reissues or additions o f or to any of the aforesaid patents and patent applications, and any additional patents or patent applications to wh ich Licensor acquires rights during the term of this Agreement w hich pertain in any way to the Compound or the Prod uct or their manufacture or use