definiens: ) Novel means of transformation of fungi and F.Hottmann - La WOOl 109352 30.07.1999 28.07.2000 their use for heterologous protein production Roche, AG Filed in MX ; EP Non - exclusive CN, JP, CA . AU ( ) Asperg ~ lus license to RB ' " CERTAIN CONFIDENTIAL INFORMATION CONTAINED iN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION RULE 246 - 2 OF THE SECURITIES EXCHANGE ACT OF 1934 . AS AMENDED . 76 . CONFIDENTIAL Rhein Biotech Intellectual Property : Vaccine Development Title Applicant I No . Priori1y Date of filing Grant of patent Date of expiry Proprietor Verfahren lOm Gewinnen von Rhein Biotech DE 19918 619.7 23.04.99 rekombinantem HBsAg ( ) WO 00165065 23.04.99 17.04.00 EP 1088076 23.04.99 17.04.00 US 6,428,984 23.04.99 17.04.00 06.08,2002 17.04.2020 KR0403220 23.04.99 17.04.00 14.10.2003 17.04.2020 . IN 23.04.99 17.04.00 Notice of allowance eN ZL00800644.X 23.04.99 17.04.00 05.01.2005 17.04.2020 Zusammensetzung von Prophylaxe I Rhein Biotech DE 10339927 29.08.2003 Therapia von HBV - Infektionen und HBV- GmbH vermitteHen Erkrankungen (, Cocktail " ) W02005/023297 29.08.2004 27.08.2004 « Delivery of immunogenic molecules via Yiesum Research US 03.02.1998 03.02.1998 HbsAg particles " Develomant Company of the WO 99/39738 29.01.1999 Hebrew Univer~$ty . _ .