definiens: means ( a ) any decision to approve or materially amend any Development Plan, including any decision ( i ) to increase, decrease or add any activities to be conducted by a Party thereunder, ( ii ) to approve oramend any Development Budget resulting in an increase in [COMPANY] ’s obligation thereunder by [ * * * ] within a given year ascompared to the initial amount budgeted for such year or by [ * * * ] for a year as compared to the estimate in the previousyear ’s budget for such year, ( iii ) to [ * * * ], or ( iv ) that would result in [ * * * ] ; ( b ) any decision to have [COMPANY] conduct anyDevelopment with respect to any Product in the Territory, beyond conducting the Rhopressa Phase 3 Clinical Trial ; ( c ) [ * * * ] ; ( d ) any decision relating to the Manufacture of Products or Compound ; ( e ) utilizing in any Development, Commercializationor other activities under this Agreement any materials, technology or intellectual property that would require any royaltyobligation to a Third Party ; or ( f ) dissolving the JDC or JCC once established