definiens: means any result, o ccurrence, fact, change, event or effect that is materially adverse to, or would reasonably be expec ted to be materially adverse to, the condition ( fin ancial or otherwise ), assets, liabilities, obligations, opera tions or Radiopharmacy Business of the Company, tak en as a whole, except for any result, occurrence, fact, cha nge, event or effect that arises out of, results fr om or is attributable to : ( i ) changes that are the result of factors generally affecting radiopharmacy and nucl ear medicine department Page 5 of 45 markets in the Territory ; ( ii ) any adverse change, effect or circumstance arising out of or resulting from actions contemplated by the Parties in connection with this Agreement or the pendency or announcement of the Transactions ( iii ) changes or proposed changes in a pplicable Laws, regulatory conditions, policies or government programs or the interpretation, application, non - ap plication, enforcement or non - enforcement of applic able Laws, conditions, policies or programs by any Gover nmental Authority ; ( iv ) any change to generally acc epted accounting principles or in the interpretation ther eof ; ( v ) any action taken at the written request of Buyer ; ( vi ) any failure, in and of itself, of the Company to meet any projection or forecast ( it being unders tood that the causes underlying the failure may be taken into acc ount in determining whether a Material Adverse Effe ct has occurred ) ; ( vi ) changes that are the result of econ omic factors affecting the national, regional or wo rld economy or securities or currency markets, or acts of war o r terrorism ; or ( viii ) any of the matters disclosed in the Schedules