definiens: means the gross amount invoiced by [COMPANY] or its Affiliates or sublicensees for the commercial sale of Product to Third Parti es, commencing with the First Commercial Sale, less deduct ions for : ( i ) normal and custo mary trade, cash and quant ity discounts actually given, credi ts, price adjust ments or allowances for damaged Products, returns or rejections of Products ; ( ii ) chargeback payments and rebates ( or the equivalent thereof ) granted to group purchasing organizat ions, managed health care organi zations or to federal, state / provincial, local and other governments, including their agencies, or to trade custom ers ; ( iii ) freight, shipping insurance and other transportati on expenses direct ly related to the sale ( if actually borne by [COMPANY], it Affiliates or sublicensees without reimbursement from any Third Party ) ; ( iv ) required distributi on commissi ons / fees payable to any Third Party 4provi ding distribut ion services to Bi oniche ; ( v ) sales, val ue - added and excise taxes, tariffs and duties, and other taxes and government charges directly related to the sale, to th e extent such items are included in the gross invoice price and actually borne by [COMPANY], its Affiliates or sublicensees without reimbursement from any Third Party ( but not including taxes assessed against the income derived from such sale ) ; and ( vi ) provisi ons for actual unco llectible amounts determined in accordance with Account ing Standards for Product sold by [COMPANY]