definiens: means an alpha - beta T cell receptor such that the T — cellengineering platform provides T cells which do not just have their endogenous TCR genes but have been transducedwith genes for the expression of an alpha - beta T cell receptor, this being defined as a protein that contains a TCRAlpha Variable Domain and a TCR Beta Variable domain, either of which can be of wild type sequence or mutated inup to 10 % of amino acid positions 1.14 means for the ex - vivo activation and expansion of human T - cells containing ENGINEEREDT - CELL RECEPTORS for use as a therapy for the TREATMENT of CANCER, INFECTIOUS DISEASE and / orAUTOIMMUNE DISEASE where such therapy comprises : ( a ) removing a sample containing T - cells from a humanpatient ; ( b ) isolating T - cells from such sample using LIFE BEAD PRODUCT or similar magnetic beads;(c ) transfecting such isolated T - cells with a gene or genes encoding ENGINEERED T - CELL RECEPTORS of knownantigen specificity ; ( d ) activating and expanding the population of such engineered T - cells using LIFE BEADPRODUCT or similar magnet beads ; and ( e ) introducing the expanded, engineered T - cells back into the same patientfor TREATMENT of such CANCER, INFECTIOUS DISEASE and/or AUTOIMMUNE DISEASE