definiens: shall mean all patents, patent applications, and invention disclosures ( all as listed on Exhibit 1.38 ) and all information, materials and other subject matter, and improvements thereof, relating to ( i ) mutants or the use thereof in screening, ( ii ) the use of novel protein engineering techniques and their application in drug discovery, ( iii ) target - directed fragment discovery and maturation to produce drug leads, including monophores, extenders and fragments and monophore, extender and fragment libraries for such purposes, or ( iv ) covalent tethering and techniques related thereto ( e.g. NMR, X - ray, mass spec . AUC, Biacore ) and its use to discover fragments and test binding hypotheses of fragments and leads : ( a ) controlled by Sunesis and/or its Controlled Affiliates prior to the Effective Date or during the Research Term ; or ( b ) made by [COMPANY] Idec in the course of activities directed to the discovery, research, or development of Collaboration Compounds ; provided, in the case of ( b ) that such item was made using or derived from Sunesis Core Technology . Sunesis Core Technology shall also include any divisions, continuations, continuations - in - part, reissues, reexaminations, extensions or other .governmental actions which extend any of the patent applications or patents in ( a ) or ( b ) above, and any substitutions, confirmations, registrations, revalidations or foreign counterparts of any of the foregoing