definiens: with respect to [COMPANY] or [COMPANY] ( the ) means : ( al any Person, or any Persons acting jointly or in concert ( as determined in accordance with the Securities Act ( British Columbia ) with respect to securities of [COMPANY], or in accordance with the securities laws of the United States with respect to securities ofCombinatoRx ), whether directly or indirectly, acquire voting securities of the Subject Party which, together with all other voting securities ofthe Subject Party 5 CONFIDENTIAL TREATMENT REQUESTED held by such Person or Persons, constitutes, in the aggregate, more than 20 % of all outstanding voting securities of the Subject Party ; ( b ) an amalgamation, arrangement or other form of business combination of the Subject Party with another corporation or corporations is completed with the result that the holders of voting securities of the Subject Party do not beneficially own, in the aggregate, 50 % or more of the outstanding voting securities of the surviving or resulting entity ; ( c ) a sale, disposition or other transfer by the Subject Party of all or substantially all of its assets ; or the Board of Directors of the Subject Party, in its discretion by resolution duly adopted by the affirmative vote of a simple majority of the votes cast by the Board of Directors of the Subject Party, determines that for purposes of this Agreement, a Change of Control has occurred or is about to occur