definiens: means that certain multi - site Int ernational Diabetes Closed - Loop Trial denominated NIH / NIDDK Grant UC4 DK 108483 sponsored by the National Institutes of Health and scheduled to run during calendar years 2016 through 2019 ( wit h a project period of 1/1/16 through 12/31/19 ) and any extensions thereof, which contemplates a trial of a algorithm application, also kno wn as an artificial pancreas system, that will use TypeZero ’ s running on a smartphone, and which system will be integrated with an insulin pump and continu ous blood glucose monitor from one or more third - pa rty manufacturers, as well as a cloud - based real - time m onitoring / alerts / database system known as 1.21 shall mean tha t certain Amended and Restated License Agreement by and between the University of Virginia Patent Foundation d / b / a University of Virg inia Licensing and Ventures Group and TypeZero dated Sep tember 4, 2015