definiens: means a breach by a Party of its obligations in a manner that fundamentally frustrates the essential purpose, characteristics or value of the transactions contemplated by this Agreement as a whole, and for clarity is not limited to a specific Collaboration Target or a Product that Binds such Collabor ation Target . Notwithstanding the foregoing, if the material breach relates to one or more Collaboration Targets or one or more Products that Bind to such Collaboration Targets and not to other Collaboration Targets or Products that Bind to such other Collaboration Targets, then the non -breaching Party shall not have the right to terminate this Agreement in its entirety, but shall have the right to terminate this Agreement with respect to Collaboration Targets and Products to which the breach pertains and c annot terminate this Agreement under this Section 22.2 with respect to the non - affected Products and Collaboration Targets . For purposes of this Section 22.2(a ), a means a breach by a Party of its obligations in a manner that fundamentally frustrates the essential purpose, characteristics or value of the transactions contemplated by this Agreement, solely as relevant to the applicable Collaboration Target o r a Product that Binds such Collaboration Target ; and for clarity is not deemed to be a material breach of this Agreement ( as such term is defined above ) with respect to the Agreement as a whole . In case of termination of this Agreement pursuant to the thi rd sentence of this Section 22.2, termination of this Agreement shall be ( i ) solely with respect to the Collaboration Target(s ) and all Collaboration ICPs, Co -Funded Products, [COMPANY] Royalty Products and Adicet Royalty Products that Bind to such Collabo ration Target ( such Collaboration ICPs and Products, and, respectively ) ; ( ii ) solely with respect to the Non -Collaboration Target(s ) and all Mice Derived Adicet ICPs and Mice Derived Adicet ICP Prod ucts that Bind to such Non -Collaboration Target ( such Mice Derived Adicet ICPs and Products, and, respectively ), or ( iii ) solely with respect to [COMPANY] Non -ICP Products that Bind to such Non -Collaboration Target ( ), in each case with respect to which such material breach pertains