definiens: means a Change of Control of Five Prime where theapplicable Third Party is one of the * * * largest companies in the pharmaceutical industry as determined by marketcapitalization as of the last day of the Calendar Quarter completed prior to such Change of Control ; provided thata Change of Control where such Third Party is ( i ) * * * or its Affiliate or Successor, ( ii ) * * * or its Affiliate orSuccessor, ( iii ) * * * or its Affiliate or Successor, or ( iv ) * * * or its Affiliate or Successor shall not be a SpecifiedChange of Control unless at the time of the closing of such Change of Control such entity satisfies the criteria setforth above and is then commercializing, or dosing patients in a Registration - Enabling Clinical Trial testing, either(A ) a molecule ( including Antibodies, peptides and chemical compounds ) that is Proprietary to such Third Partythat ( 1 ) * * *, and ( 2 ) ( a ) * * * or ( b ) * * *, ( B ) a molecule ( including Antibodies, peptides and chemical compounds ) thatis Proprietary to such Third Party that ( 1 ) * * *, and ( 2 ) ( a ) * * * or ( b ) * * *, ( x ) * * * or ( y ) * * *, or ( C ) * * * that is Proprietary tosuch Third Party, in any case ( ( A ) through ( C ) ) in the field of Oncology