definiens: . Commercially Reasonable Efforts means, with respect to the effo11s to be expended by a Party with wspect to a goal, such reasonable, diligent, good faith efforts to accomplish such goal as a similarly situated ( with respect to size, stage ofdevelopment, and assets ) biotechnology company would use to accomplish a similar goal under similar circumstances so as to achieve such goal in a reasonable period oftime ; provided ~bat ., with respect to the development, manufacturing or commercialization ofa Collaboration Product, such effo11s shall be substantially equivalent to those efforts and resources that a similarly situated ( with respect to size, stage ofdevelopment, and assets ) biotechnology company would typically devote to its own internally discovered products of similar market potential at a similar stage in their development or product life, taking into account issues ofsafety, efficacy, product profile, the competitiveness ofthe marketplace, the proprietary position ofthe compound or product, the regulatory and reimbursement structure involved, the profitability ofthe applicable product, and other relevant factors, so as to achieve such goal in a reasonable period oftime ( which, with respect to activities for which ' fhromboGenics is responsible, shall he without regard to any amounts paid or payable to EBI with respect to a Collaboration Product under this Agreement )