definiens: means, ( A ) with respect to the Development, Manufacture or Commercialization byAstraZeneca of a product, at any given time as the case may be, efforts and resources reasonably used by [COMPANY] or itsAffiliates ( giving due consideration to relevant industry standards ) for [COMPANY] ’s own products ( including internallydeveloped, acquired and in - licensed products ) with similar commercial potential at a similar stage in their lifecycle ( assumingcontinuing development of such product ), taking into consideration their safety, tolerability and efficacy, the profitability(taking into account any payments payable under this Agreement ), the extent of market exclusivity, patent protection, cost todevelop the product, promotable claims, and health economic claims, and ( B ) with respect to the Development by POZEN of aproduct, at any given time as the case may be, efforts and resources reasonably used by an entity in the pharmaceuticalindustry of similar resources and expertise as POZEN, for such similar entity ’s own products ( including internally developed, acquired and in - licensed products ) with similar commercial potential at a similar stage in their lifecycle ( assuming continuingdevelopment of such product ), taking into consideration their safety, tolerability and efficacy, the profitability ( taking intoaccount any payments payable under this Agreement ), the extent of market exclusivity, patent protection, cost to develop theproduct, promotable claims, and health economic claims