definiens: shall mean use as a human topical microbicide, alone or in combination with other compounds, for application to the skin, mucosal and/or epithelial tissue as an active ingredient in formulations such as creams, foams, jellies, orother similar formulations, including contraceptive and other vaginal delivery devices such as sponges, intrauterine devices, diaphragms and condoms ; but Permitted Field of Use does not include, and specifically excludes : ( a ) non - human uses ; ( b ) human application for both systemic therapeutic uses and systemic post - exposure prophylactic uses ; and ( c ) uses when applied to or incorporated into any surface ( except for human surfaces consisting of skin, mucosal and / orepithelial tissue ) or device ( except contraceptive and other vaginal delivery devices as provided for above in thisSection 1.7 ) including, but not limited to, gloves, aprons, tubing and filters