definiens: means a product approved for marketing in a country for the diagnosis, treatment or prevention of human disease indications and : ( i ) which has Inhibitory Activity against an Aminoacyl -tRNA Synthetase, provided that the active substance in such product ( or, if such active substance is an analog of the original active substance in such product, then such original active substance ) shall not h ave been identified by, or was not known to, [COMPANY] or any of its Affiliates or funded research collaborators, and was not generally known to the public, as possessing Inhibitory Activity against such Aminoacyl -tRNA Synthetase prior to the date that such active substance was first identified as having Inhibitory Activity against an Aminoacyl -tRNA Synthetase by reason of the Primary and/or Secondary Screening Programs conducted by a party under this Agreement ; and ( ii ) for which the right to make, have made, use or sell such product or the active substance in such product has not been licensed to [COMPANY] or its Affiliates by a Third Party ( A ) who had identified or ascertained, independe ntly of any activity conducted by [COMPANY] or [COMPANY] pursuant to this Agreement, that the active substance in such product ( or, if such active substance is an analog of another active substance in such product provided by such Third Party, then such original active substance ) possessed significant Inhibitory Activity against an Aminoacyl -tRNA Synthetase for which such substance or product is targeted, and ( B ) who had identified or ascertained same prior to the date that said active substance was first identified as having Inhibitory Activity against an Aminoacyl -tRNA Synthetase by reason of the Primary and/or Secondary Screening Programs conducted by a party under this Agreement ; and ( iii ) is not an approved PLP compound or marketed drug 4s of the Effective Date