definiens: means all unpatented Know - How that ( i ) is owned o r Controlled by [COMPANY] or its Affiliate as of the Effective Date of this Agreement, or owned or Controlled by Xenco r or its Affiliate thereafter during the Collaboration Term, and ( ii ) is necessary or useful for Licensed Antib ody, and/or Licensed Product development and/or commercializati on ( including Know - How relating to any method of making, using ( including methods of administration and dosing regimens ) or testing of ( or in the case of testing, of or for the presence of ) or manufacturing of a Li censed Antibody and/or Licensed Product ) or any art icle necessary or useful to practice ( including those pr esent during the practice of any of such method ) an y of the foregoing ; but specifically excluding computational protein design methods and drug discovery ( but not development ) methods and Know - How of an acquiror an d / or the acquiring corporate family existing prior to or on the date of a [COMPANY] Change of Control or indepe ndently of [COMPANY] thereafter ( for clarity, in the c ase where [COMPANY] is merged into another entity, * * * Confidential Treatment Requested the references here to and mean to refer to and )