definiens: mean a fiiOIOgiCal or chemical system that, within a high throughput screening envirorunent for the identification of modulators of a particular receptor or other target, is able to produce a detectable readout ( e.g., luminescence, fluorescence, colorimetric shift, radiation ) upon application of a desired stimulus ( increase or decrease in ion concentration, activation ordepre ~ sionofapromoter gene sequence, activation of a G - protein signal, enzymatic activation, protein - protein interaction, protein - nucleic acid interaction, etc . ), and includes, without limitation, any Reporters that ate used or useful therein that are owned or Controlled by Aurora during tlle . term of this Agreement .. means : the substrates and other tools / reagents used in a Reporter System, including but not limited to beta - lactamase, ultra - bright GFP ( kinase and protease ), promiscuous G, proteins, voltage - sensitive probes, and calcium memory pr ~ j ' The Reporters available as ofthe Effective Date are described on Exhibit 1.2 attached hereto