definiens: means any Know - How Controlled by Sangamo or its Affiliates as of the Effective Dateor during the Term ( other than through the grant of a license by [COMPANY] Idec hereunder ), including Sangamo ’s interestin Joint Know - How, that is necessary [ * * * ] to Research, develop, manufacture, commercialize, market, import, export, sell or offer for sale or otherwise use a Licensed Product for any purpose in the Field, including any such Know - Howcovering or relating to : ( a ) methods for obtaining unmodified hematopoietic stem and progenitor cells ( ) from asubject, including procedures for purifying, storing, propagating or transporting such cells, ( b ) methods for modifyingthe HSPCs ex vivo, including techniques for purifying, propagating, storing or transporting the modified HSPCs,(c ) methods for making and using ( but not designing or optimizing ) DNA - Binding Molecules and molecules or vectorsencoding such DNA - Binding Molecules for use in modifying the HSPCs ex vivo by Specifically Binding to a GeneTarget or Safe Harbor Locus, ( d ) methods for testing, assaying and characterizing HSPCs, mRNAs and cell banks,(e ) procedures for manipulating, storing, purifying, propagating or using such modified HSPCs and all progeny anddifferentiated forms thereof, ( f ) techniques for administering such modified HSPCs or progeny or differentiated formsthereof to subjects, ( g ) a method for isolating, manipulating, propagating and/or storing CD34 + cells obtained from ahuman or animal subject and ( h ) any methods for detecting such CD34 + cells or HSPCs in the subjects afteradministration . For clarity, Licensed Know - How 11excludes Know - How related to the design and optimization of any nucleic acid - binding protein, including any ZincFinger Protein, TALE Protein or CRISPR / Cas system . Notwithstanding anything in this Agreement to the contrary, theLicensed Know - How shall not include any Know - How licensed to Sangamo or its Affiliates by a Third Party unlesssuch Know - How is licensed pursuant to a Third Party License