definiens: means, subject to the exclusion set forth below for general and administrative employees, imputed costs of a Party ’s employees ’ labor in furtherance of activities under this Agreement, as calculated at a rate of per hour ( or such other rate as the Parties may mutually agree in writing with respect to certain employees or classes of employees ) in calendar year 2015, subject to annual adjustment on each anniversary of the Effective Date thereafter to reflect CPI increases ; provided, however, that where a Party can demonstrate through credible data that, at any time later than the second anniversary of the Effective Date, increases in average salaries for comparable life - sciences companies exceed CPI increases, such Party may increase its FTE Cost rates to reflect such average salary increases . For purposes of this Agreement, the term means the Consumer Price Index for all Urban Consumers ( CPI - U ) for San Francisco - Oakland - San Jose, CA, all Items ( 1982 - 1984 = 100 ), as published by the United States Bureau of Labor Statistics, or if such index is no longer published, then the index most comparable thereto