definiens: means the fol / owing patents : those of Roche Molecular Systems, Inc. and F. Hoffmann - La Roche Ltd : United States Patent Nos . 4,683,202, 4,683,195, 4,965,188, 5,210,015,5.487,972,5,476,774, and 5,219,727, and corresponding foreign counterpart patent claims, and Roche 's United States Patent No . 5,804,375 ( Claims 1 - 12 ) and foreign counterpart claims, covering 5 ' Nuclease reaction mixtures ; and those of [COMPANY] Corporation : United States Patent Nos . 5,538,848, 5,876,930, 6,030,787, 6,258,569 81 and 5,656.493, and corresponding foreign counterpart patent claims