definiens: means the dale on which all of the followmg shall have occurred : ( I ) this Agreement shall have been duly executed and dchvcrcd by all of the Parties hcrClo;and ( 2 ) the Progenies - Wyeth Agreement shall have been duly executed and deltvered by Progenies and Wyeth and shall be in full force and efftet, E ~ c1uded Molecules . means chemically defined as and ilS pharmacolo gically acceptable ( OJ CONF / OHITIA L 1ll£<DlENTH(lUFSTU ) CONf'WENTLAL I'OIITf(lNOMfTJW,(J(tJ FI / JiDSl : PAurur rrm nlE CfN.IMI!iSKJN 11 CONH / JENTIAL salts, tQKether with their solvllte5 . hydrates, hemihytlrat es, metabolites, pro - drugs, esters, and if apphcable, any tsomers or mcemates thereof, Patent Rights . means any and all ( I ) U.S. or foreign palents, ( b ) U.S. 01 " foreign patent application s, Including . without limitation, all provisional applications, substitutIOns, continuatIons . continuatlOns - in- part . divisions . renewals . and all p-1tenUl granted thereon, ( c ) all U.S. or foreign patcnlS -- of -aJdillOn, reissues, rec ~ aminations and extensions or re ~ tor ... tjons by existing or future ro : tension or restoration mechanisms