definiens: means the gross price at which a product is sold to a third party after discounts, deductions, credits, taxes and allowances ( ii ) If : ( a ) neither of the therapeutica lly active pharmaceutical ingredients of a Combination Product are sold separately in commerci ally relevant quantities during a particular paymen t period, or ( b ) a Combination Product has * ( * ) or more th erapeutically active pharmaceutical ingredients in addition to the Licensed Product, then, in any such case, the P arties will meet and negotiate an appropriate metho d for determining the * resulting from sales of such Comb ination Product, taking into account the contributi on each therapeutically active pharmaceutical ingredient ma kes to the total selling price of such Combination Product, based on the principle behind the formulas above an d with reference to a mutually agreed sampled media n of comparable branded, non - generic or non - biosimilar p roducts comprised of BTK ( e.g., * ), * ( e.g., * ) ( * ) / * ( * ), * and ( * ), or * ( e.g., * ) agent as a monotherap y for use in the Field