definiens: means all Qb VLPs, including CYT003, containing least one of the following:(a ) a TLR9 agonist encapsulated within said Qb VLP, and wherein said Qb VLP is not conjugated withany other molecule;(b ) a TLR9 agonist encapsulated within said Qb VLP, and wherein said Qb VLP is conjugated with [ * * * ], or with [ * * * ] ; ( c ) a TLR7 agonist, including without limitation [ * * * ], encapsulated within said Qb VLP, and wherein saidQb VLP is not conjugated with any other molecule;(d ) a TLR7 agonist, including without limitation [ * * * ], encapsulated within said Qb VLP, and wherein saidQb VLP is conjugated with [ * * * ] ; 6(e ) a RIG - I agonist encapsulated within said Qb VLP, and wherein said Qb VLP is not conjugated withany other molecule ; or(f ) a RIG - I agonist encapsulated within said Qb VLP, and wherein said Qb VLP is conjugated with [ * * * ]