definiens: means Know - How that ( a ) is Controlled by EISAI as of the Prior Agreement EffectiveDate or at any time thereafter prior to the expiration of the Target Exclusivity Period, ( b ) arises outside of theCollaboration, and ( c ) is necessary or reasonably useful for the Development, Manufacture or Commercialization ofLicensed Compounds and Licensed Products in the Field in the Territory, but expressly excluding any Know - HowControlled by EISAI that relates to any compound or molecule that is not a Compound directed to EZH2 . For purposesof clarity, EISAI Know - How includes Diagnostic Know - How Controlled by EISAI as of the Prior Agreement EffectiveDate or at any time thereafter prior to the expiration of the Target Exclusivity Period, but excludes any CollaborationKnow - How owned by EISAI and EISAI ’s interest in any Joint Know - How