definiens: means, with respect to a Licensed Compound, a comprehensive, tritilti"'year plan, as may be amended from time to time in accordance with Section 4.4 specifying ~tiliiqarafldll()n - clj)')j9~1])eyeloPll1emt ~ etails for such Licensed Compound ( including, without limitation, the jJl-9~8~~~qJi$rJ ~ f ......... · · · p.~P~!i ~ py;t ~ m ~ Hh¢~;:f01'cQrnPletiTIgkey ~ cttYities : pnasihg of development, l#~m ~ fYl : irig .... . .. ~ for ~p#fih4}ng activities, study size, comp ~ rator drugs, .. c0tnbillatio.n •.• dt - ttSs,.~~~e1ines for.d ~ t ~ g~~p~~~tioll.~Il.~.tl1ing of regulatory submissions, t();Xi~.ology.and.pl1Wlll~99IpgX studies an9m ~ n : ntf~9lHn, P : gPF99!i(stJ development and sQa1yqp;.pt¢e IDirketingaridp6st ~ rtiWl(~tii1gresearch:~~~p ~ titiv~~~~lyses, ~arketing, launching ~llded ~ cation plans and activities ) for all applicable countries in the Territory . The initial Development Plan as of the Effective Date is attached hereto as Appendix 2