definiens: means the invoiced price of a Productcharged to an unaffiliated end user in the Territory ( i.e :, athird party whose use is intended to result in the consumption ordestruction of the Product ), net of returns and rejections, andafter deducting, ( i ) sales or similar taxes, pa ~ kaging charges, freight and insurance, to the extent charged to the purchaser ordirectly attributable to the specific sale, ( ii ) cash, trade andquantity discounts actually allowed and taken, and ( iii)allowances, rebates and commissions actually taken or paid . Withrespect to sales of a Product in the Royalty Territory, if aProduct is sold with a single invoiced price in combinat.ion withanother therapeutically active component or components or as acombination with diagnostic products where one or more componentsor products are not Products, Net Sales under such circumstancesshall be calculated by multiplying Net Sales of the combinationby the fraction A/(A B ), in which A is the invoiced price of theProducts, if sold separately, and B is the total invoiced priceof any other active components or components in combination, ifsold separately . If the Product and/or the active components orcomponents in the combination are not sold separately, the valuesof the individual components shall be reasonably determined bythe Management Committee . The value of the components of thecombination will be based on, but not limited to, the cost ofmanufacturing, the value of comparable components marketed byothers and the potential value based on the current cost ofdiagnosing and treating the disease . In the case of acombination product marketed by the Collaboration in the MajorMarkets, the Management Com ~ itte~ shall determine . t ~ e.portion.ofthe invoiced price of -such product that -is:--to · be t : reat ~ d as NetSales under this Agreement