definiens: shall mean the gross amounts invoiced by PINT and its Affiliates and Sublicensees for sales of the Product ( including, for the avoidance of doubt, the NPP Product ), less the following deductions to the extent shown in the invoices for sales of the Product or otherwise directly paid, allowed, accrued, or incurred by PINT or its Affiliates and Sublicensees with respect to sales of the Product ( if not previously deducted from an amount invoiced ): ( i ) normal and customary trade discounts, credits or allowances actually given ; ( ii ) credits or allowances additionally granted upon returns, rejections, rebates or recalls ( except where any such recall arises out of the gross negligence, willful misconduct or fraud of the selling party ) ; ( iii ) sales, excise, turnover, value -added and similar taxes on the sale of the Product ( but not, for the avoidance of doubt, taxes on net income or withholding therefor ) ; and ( iv ) transportation, freight, postage, importation, shipping insurance and other handling expenses . In additi on, Net Sales for any period may be reduced by any retroactive discounts, price reductions or rebates required by applicable laws or regulations and actually paid by PINT during the period in question, provided that PINT provides, at the time such reductio n is made, reasonable evidence concerning the calculation and payment of such amounts . All the discounts, allowances, credits, rebates and other deductions described above not solely related to the Product shall be fairly and equitably allocated to such sa les of the Product such that the Product does not bear a disproportionate portion of such deductions . For purposes of determining Net Sales, the Product shall be deemed to be sold when invoiced and a shall not include transfers, uses or dispositions for promotional, preclinical, clinical, regulatory or governmental purposes, in each case if no compensation is received by PINT, its Affiliates or its Sublicensees . For purposes of calculating Net Sales, sales between or among PINT and its Affiliates or any Sublicensee and its Affiliates shall be excluded from the computation of Net Sales ( unless the Affiliate or Sublicensee is the end user of the Product ), but sales by PINT and its Affiliates and Sublicensees to Third Parties shall be included in the computation of Net Sales . In all cases, deductions taken into account in the computation of Net Sales shall not exceed ( on an invoice by invoice basis ) in the aggregate thirty percent ( 30 % ) of the gross amounts invoiced by PINT and its Affiliates and Sublicen sees for sales of the Product