definiens: means ( a ) with respect to activities of ARQULE in the DevelopmentProgram, the Development of a particular Licensed Product and/or in the Commercialization of any Co - CommercializedLicensed Product, the efforts and resources comparable to those undertaken by ARQULE in pursuing intellectual propertyprotection and the research, discovery or commercialization of proprietary materials and the development of product candidates, as applicable, that are not subject to the Collaboration and that are at an equivalent stage of development or commercializationand have similar market potential and are at a similar stage in their lifecycle ; and ( b ) with respect to activities of DS in theDevelopment Program, the Development of a particular Licensed Product and/or in the Commercialization of a particularLicensed Product ( including any Co - Commercialized Licensed Product ), the efforts and resources comparable to thoseundertaken by DS in pursuing intellectual property protection and development of product candidates and commercialization ofproducts, as applicable, that are not subject to the Collaboration and that are at an equivalent stage of development orcommercialization and have similar market potential and are at a similar stage in their lifecycle