definiens: is defined in Section 10.24.4 1.57 means with respect to a Product fo r any period, the total amount billed or invoiced o n sales of such Product during such period by Spero, its Affiliates, or Sublicensees to Third Parties ( i ncluding wholesalers or distributors ), in bona fide arm ’s le ngth transactions, less the following deductions, i n each case related specifically to the Product and actually al lowed and taken by such Third Parties and not other wise recovered by or reimbursed to Spero, its Affiliates, or Sublicensees : ( a ) trade, cash and quantity dis counts ; ( b ) price reductions, rebates or charge backs, retr oactive or otherwise ( including Medicare, Medicaid, managed care and other similar types of rebates and chargeb acks ) ; ( c ) taxes on sales ( such as sales, value add ed, or use taxes, but excluding taxes assessed or assessable a gainst the income Portions of this Exhibit, indicated by the mark were omitted and have been filed separately w ith the Securities and Exchange Commission pursuant to the Registrant ’s application requesting confidential treatment pursuant to Rule 406 of the Securities Ac t of 1933, as amended