definiens: shaH mean : ( a ) with respect to [COMPANY], the gross amounts invoiced by any of [COMPANY] or its Affiliates or sublicensees on account of sales of a Collaboration Product [ or Ex - Program Product, as applicable ], to Third Parties ( including without limitation Third Party distributors and wholesalers ), less the total of : ( i ) Trade, cash and/or quantity discounts actually allowed which are not already reflected in the amount invoiced ; ( ii ) Excise, sales and other consumption taxes ( including VAT on the sale of Collaboration Products [ or Ex - Program Products, as applicable ) ] ) and custom duties to the extent inc1uded in the invoice price and to the extent such taxes are remitted to the applicable taxing authority ; ( iii ) Freight, insurance and other transportation charges to the extent included in the invoice price and separately identified on the invoice or other documentation maintained in the ordinary course of business ; ( iv ) Amounts repaid or credited by reason of returns, rejections, defects or recalls or because of chargebacks, retroactive price reductions, refunds or billing errors ; and ( v ) Compulsory payments and rebates directly related to the sale of Collaboration Products [ or Ex - Program Products, as applicable ], accrued, paid or deducted in a manner consistent with generally accepted accounting principles, pursuant to agreements ( including, but not limited to, managed care agreements ) or govemrnentalregulations