definiens: means ( a ) with respect to BEZ235, the treatment, prevention and diagnosis of diseases and other conditions in all Indications in humans and animals ; and ( b ) with respect to RAD001, limited to uses together with BEZ235 as part of a Fixed Dose Combin ation that includes at least 0.1 mg of BEZ235 per dose, for any Indication in humans related to ( i ) the improvement in immune function or immunosenescence in the elderly ; ( ii ) the reduction of infection frequency, severity, du ration, health care resource utilization, hospitalization, morbidity or mortality, or the treatment of infections ; ( iii ) the reduction of pulmonary disease exacerbation frequen cy, severity, or related hospitalization ; ( iv ) the enhancement of therapeutic or prophylactic benefits of vaccines ; or ( v ) any aging - related disease or condition ; provided, however, that notwithstanding the foregoing, the Field doe s not include application or use of RAD001 in connection with organ transplantat ion, oncology, immuno- oncology or in the Cardiac Stent Field . For this purpose, the term means the prevention and/or treatment of coronary and peripheral vascular diseases with sten ts, stent delivery systems or other site - specific l ocal, vascular delivery systems, but does not extend to a ny systemic application . It is understood and agree d that the Field also does not include any rights for resT ORbio to develop, make, use and sell RAD001 ( A ) in any combination other than a Fixed Dose Combination ; ( B ) by itself ( except in connection with the Development of a Fixed Dose Combination as set fort h in Section 5.1 of this Agreement ) ; or ( C ) in any use outside of the Indications described in clauses ( i ) through ( v ) of the preceding sentence