definiens: means all Know - How Controlled by Isis or its Affiliates on the EffectiveDate or at any time during the Term necessary to Research, Develop or Commercialize a Product or disclosed by Isisto [COMPANY] and specifically relating to ( i ) the composition of matter of a Lipid Drug or Product or ( ii ) methods of using aLipid Drug or Product as a prophylactic or therapeutic ; provided however, Know - How Controlled by Isis or any of itsAffiliates that ( y ) consists of subject matter applicable to oligonucleotide compounds or products in general or(z ) relates to an oligonucleotide compound that does not specifically modulate expression of a Lipid Drug Target viathe binding, partially or wholly, of such compound to RNA that encodes a Lipid Drug Target, will not be considered IsisProduct - Specific Know - How, and in the case of ( y ) and ( z ), such Know - How will be considered Isis Core TechnologyKnow - How