definiens: shall mean an HTS Chip Device developed to the point of a prototype instrument, but not developed or certified as a Commercial Instrument, that is functionally capable, when operated by trained personnel under reasonable operating conditions, of performing with one or more types or designs of Microfluidic Chips an assay in each of the following categOries : ~luble enzyme, membrane bound enzyme, soluble receptor, and 9 = " ' ( ) membrane bound recept ; ; ; at an assay throughput of approximately 100,000 assays per 16 hour day - Wlth only reasonable process interruptions consistent with the prototype nature of the instrument, that otherwise materially satisfies the Functional Requirements . In the event that PRI determines to accept and pay for Substitute Prototype Devices pursuant to Section 6.4 below, each such Substitute Prototype Device shall be deemed to be Prototype HTS Chip Device within the meaning of this Agreement . For the purposes of this Agreement, Low Throughput Devices shall not be deemed to be Substitute Prototype Devices