definiens: means, with respect to each Licensed Product in a country in the EPIZYMETerritory or EISAI Territory, the first sale for which revenue has been recognized by the Applicable CommercializationParty or its Affiliates or Sublicensees for use or consumption by the general public of such Licensed Product in suchcountry after Regulatory Approval ( and pricing or reimbursement approval, if legally required for such sale ) for suchLicensed Product has been obtained in such country ; provided, however, that the following shall not constitute a FirstCommercial Sale:(a ) any sale to an Affiliate or Sublicensee unless the Affiliate or Sublicensee is the last entity in thedistribution chain of the Licensed Product;(b ) any use of such Licensed Product in Clinical Trials, non - clinical activities or other Developmentactivities, or disposal or transfer of Licensed Products for a bona fide charitable purpose ; and(c ) treatment IND sales, named patient sales, or compassionate use