definiens: means a gene and the products encoded by such gene that [COMPANY] has elected to exclude from consideration as a Selected Targett!akeda may divide the list of Excluded Targets into two ( 2 ) categories identified by [COMPANY] ( ~out any determinative effect under this Agreement ) as : ( a ) '' public domainother.::fEach Excluded Target shall be identified by the full - length cDNA and/or amino acid sequence of the gene or, in the event the gene has more than one splice variant form, by the full - length cDNA and/or amino acid sequence of at least one splice variant form of such gene . A list of such Excluded Targets shall be provided to the Escrow Agent who shall notify Lexicon and Taked ~ Ch, if any, Targets submitted in accordance with Section 2.2(a)(iii ) are Excluded Target and in which of the categories identified by [COMPANY] such Targets fall . [COMPANY] may update the list of Excluded Targets with respect to any Target at any time prior to the submission by Lexicon of that Target to the Escrow Agent in accordance with Section 2.2(a)(iiQ]Genome 5000 Program " means a project conducted by Lexicon to ( a ) analyze the physiological and behavioral phenotypes of Knock - Out Mice corresponding to approximately 5,000 human genes ; and ( b ) based on such physiological and behavioral information, select 3 * Confidential Treatment Requested targets for drug discovery programs that, when knocked out, exhibit favorable therapeutic profiles for the development of drug products