definiens: shall mean any plasmid which, upon the insertion of a gene encoding a GPCR, forms a Tail Modified Plasmid, including without limitation pNRKneo - EArrB - l and all other such plasmids described in U.S. Patent Application No . 09/993,844 . ] [ Tail Modified Assay . shall mean a Transfluor Assay in which the GPCR is a Tail Modified GPCR, including without limitation all such assays described in U.S. Patent Application No . 09/993,844 . ] [ Tail Modified GPCR . shall mean any GPCR encoded or expressed by a Tail Modified Plasmid, including without limitation all such GPCRs described in U.S. Patent Application No . 09/993,844 . ] [ Tail Modified Plasmid . shall mean any plasmid encoding a GPCR having a modified carboxyl - terminus which causes increased arrestin - GFP binding when [ 1 = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B·2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED