definiens: shall mean, with respect to the efforts to be expended by a Party with respect to a goal, reasona ble, diligent, good faith efforts to accomplish suc h goal as a similarly situated ( with respect to size, stage of development, and assets ) biotechnology or pharmaceu tical company, as the case may be, would use to accomplis h a similar goal under similar circumstances so as to achieve such goal as expeditiously as possible ; pro vided that, with respect to the Development and Commercialization of the Product, such efforts shal l be substantially equivalent to those efforts and resources that a similarly situated ( with respect to size, st age of development, and assets ) biotechnology or ph armaceutical company, as the case may be, would typically devote to its own internally discovered products of simil ar market potential at a similar stage in their development o r product life so as to achieve such goal as expedi tiously as possible ( which, with respect to activities for whi ch Chiesi is responsible, shall be without regard t o any amounts paid or payable to uniQure with respect to the Prod uct under this Agreement, the Commercialization Agr eement, or the HemB Supply and Distribution Agreement )