definiens: means all Patents Controlled by Isis or its Affiliates on the Effective Date orat any time during the Term Covering ( i ) the composition of matter of a Lipid Drug or Product, or ( ii ) methods of usinga Lipid Drug or Product as a prophylactic or therapeutic ; provided however, Patents Controlled by Isis or any of itsAffiliates that include only claims that are directed to ( y ) subject matter applicable to oligonucleotide compounds orproducts in general or ( z ) an oligonucleotide compound that does not specifically modulate expression of a Lipid DrugTarget via the binding, partially or wholly, of such compound to RNA that encodes Lipid Drug Target, will not beconsidered Isis Product - Specific Patents, and in the case of ( y ) and ( z ), such Patents will be considered Isis CoreTechnology Patents . A representative list of Isis Product - Specific Patents as of the Effective Date is set forth onAPPENDIX 3