definiens: means Patent Rights Controlled by Isis or any of its Affiliates on or after theEffective Date claiming both : ( i ) a sequence - based composition of matter that generically encompasses the [ * * * ] Development Candidate oran [ * * * ] Lead Compound ( or any [ * * * ] Product incorporating such [ * * * ] Development Candidate or any [ * * * ] Lead Compounds ), or methods of using the [ * * * ] Development Candidate or an [ * * * ] LeadCompound ( or any [ * * * ] Product incorporating such [ * * * ] Development Candidate or any [ * * * ] LeadCompounds ), as a prophylactic, therapeutic or diagnostic but, in each case, does not claim the specific [ * * * ] Development Candidate or an [ * * * ] Lead Compound ( or any [ * * * ] Product incorporating such [ * * * ] Development Candidate or any [ * * * ] Lead Compounds ) ( the exact sequence and chemistry ) ; and ( ii ) an Isis [ * * * ] -Field ASO, or method for [ * * * ] of Isis [ * * * ] Field ASOs for the treatment of a [ * * * ] disease