definiens: means the proteins FK-506 Binding Protein ( ), calcineurin, cyclophilin or any other protein(s ) designated as a Target Protein by written agreement of the parties ( hereinafter sometimes collectively referred to as Program Compound " means : ( i ) any chemical compound which has signi ~ cant imm.unosuppres ~ ive activity deriving principally from its interaction with a Target Protem and whIch IS conceIved by or on behalf of [COMPANY] or JT, independently or jointly, as the case may be, m the Research Program during the Research Term, provided such compound is shown by or on behalf of [COMPANY] or JT, independently or jointly, during the Research Term or within one ( I ) year thereafter to have a Ki against a Target Protein of : 5 I ~ M concentration ; ( ii ) any Analog of a chemical compound described in clause ( i ) above which has significant immunosuppressive activity deriving principally from its interaction with a Target Protein and which is conceived by or on behalf of [COMPANY] or JT, independently or jointly, during the one ( I ) year period after the end of the Research Tenn