definiens: means)IDy Compound ~hic.hin the course of screening such Compound by or for U PD.ijsing either a Collaborative Sc ~ e ~ nor the fully integrated screening capability of the v System hereunder demonstrates actlVltyl meansilltdirst to occur of the following : ( i ) the filing with and acceptance by the \ I F;DAof an Investigational New Drug application ; or ( ii ) any corresponding application < ! JJ filed . in.@ycountry other than the United States ; or ( iii ) the first administration of a Development Compound into a human subjiill means@y research conduCted by PD at the premises of PD for the \ A .. ... ct.iSCO.v ..... e .. ry ..... Of . I.h .. era.peutics to be develope . d .. and markel .. e~ SOl . elY. by P~ or jointlyby pD qJ and'aJ'hirdPll.rty mcludmg the development and screemng at the premIses ofPD of drug screening assays . using targets provided to PD by any such Third Par£ ] \ f, meansG.PY new and useful process, machine, manufacture, or composition of 7 . matter, or improvement thereto, whether or not patentaqIi !, me ~ ns ~~~t!~nl!P4~;Ha::«j],j, s~. i~ .. n!l.f g9[lerally known to th~ public,