definiens: means, with respect to Isis, ( a ) a merger or consolidation of Isis with a Third Party which results in thevoting securities of Isis outstanding immediately prior thereto ceasing to represent at least 50 % of the combined voting powerof the surviving entity immediately after such merger or consolidation, ( b ) a transaction or series of related transactions inwhich a Third Party, together with its Affiliates, becomes the owner of 50 % or more of the combined voting power of Isis’outstanding securities, ( c ) the sale or other transfer to a Third Party of all or substantially all of Isis ’ business to which thesubject matter of this Agreement relates, or ( d ) the stockholders or equity holders of Isis will approve a plan of completeliquidation of Isis or an agreement for the sale or disposition by Isis of all or a substantial portion of its assets, other thanpursuant to the transaction as described above or to an Affiliate . Notwithstanding the foregoing, the sale or issuance of sharesin exchange for cash for purposes of a bona fide financing will not constitute a Change of Control