definiens: means a mammalian orthologue of a [ Candidate Target or Pursued Disclosed Target that [COMPANY] discovers based on work hereunder on a [COMPANY] Compound for which [COMPANY] knew, prior to providing such compound to [COMPANY], the human target ( the ) for efficacy, which orthologue ) ( a ) was identified by or on behalf [COMPANY] pursuant to work under the Mode of Action Program [ or by or on behalf of [COMPANY] or its Affiliate or sublicensee through the use to any material extent of such Candidate Target or Pursued Disclosed Target or any DNA sequence information relating thereto, or any other Research Results that Remains Confidential at the time of such use, and ( b ) [COMPANY] uses in screening, primarily to improve the efficacy - independent profile ( e.g., metabolism, safety or toxicity ) of compounds active against such Prior Target ]