definiens: means an alpha - beta T cell receptor such that the T — cell engineering platform provides T cellswhich do not just have their endogenous TCR genes but have been transduced with genes for the expression of an alpha - beta T cell receptor, this beingdefined as a protein that contains a TCR Alpha Variable Domain and a TCR Beta Variable domain, either of which can be of wild type sequence ormutated in up to 10 % of amino acid positions 1.14 means for the ex - vivo activation and expansion of human T - cells containing ENGINEERED T - CELL RECEPTORS for use as atherapy for the TREATMENT of CANCER, INFECTIOUS DISEASE and/or AUTOIMMUNE DISEASE where such therapy comprises : ( a ) removing asample containing T - cells from a human patient ; ( b ) isolating T - cells from such sample using LIFE BEAD PRODUCT or similar magnetic beads;(c ) transfecting such isolated T - cells with a gene or genes encoding ENGINEERED T - CELL RECEPTORS of known antigen specificity ; ( d ) activating andexpanding the population of such engineered T - cells using LIFE BEAD PRODUCT or similar magnet beads ; and ( e ) introducing the expanded, engineeredT - cells back into the same patient for TREATMENT of such CANCER, INFECTIOUS DISEASE and/or AUTOIMMUNE DISEASE