definiens: means nucleic acid polymers that encode proteins whoseprimary recognized enzymatic activity is to ( i ) selectively induce double or single strandedbreaks in a DNA or RNA sequence, or ( ii ) substitute, replace or delete a particular base or set ofbases of a DNA or RNA sequence in the absence of a double or single stranded break in theDNA or RNA . Gene Editing Technologies include, but are not limited to : CRISPR - Cas systems(including different Cas nucleases ), Zinc finger nucleases, meganucleases, TALENS or baseeditors . For clarity, does not include chromosomal integration of atransgene introduced by a parvovirus vector in the absence of exogenous nucleases.1.43 means, with respect to a particular Licensed Product in a country, a genericor biosimilar pharmaceutical product, that is not licensed or owned by Licensee, any of itsAffiliates or Sublicensees, that is approved for use in such country by a Regulatory Authority byreferencing the prior approval, in whole or part, or safety and efficacy data submitted in supportof the prior approval, of such Licensed Product