definiens: means, initially, $ 500,000,000, and, thereafter, such amount as reduced by the aggregate price paid from time to time after the Closing by the Purchaser or any of its Aﬃliates to the Company or any Subsidiary of the Company for each purchase from the Company or any Subsidiary of the Company of any Equity Securities by any of them, whether pursuant to the Market Price Option Agreement, the Governance Agreement, this Agreement or otherwise except for ( i ) purchases by the Purchaser or its Aﬃliates in connection with collaborations entered into by Purchaser or its Aﬃliates and the Company in accordance with the terms of the Cooperation and Collaboration Agreement dated as of the date hereof between Ciba and the Company ( ii ) Equity Securities issued to Ciba or its Aﬃliates in accordance with the terms of the Research and Development Agreement referred to in Section 5.16 of the Investment Agreement