definiens: means ( 1 ) licenses granted by [COMPANY] before or aft er the Effective Date to any Third Party under the [COMPANY] Core Technology Patents, the [COMPANY] Manufacturing and Analytical Patents, or the [COMPANY] Manufacturing and Analytical Know - How ( but not unde r the [COMPANY] Product - Specific Patents ) to ( a ) use oligonucleotides ( or supply oligonucleotides to end users ) solely to conduct non - clinical research, or ( b ) enable such Third Party to manufacture or formulate oligon ucleotides, where [COMPANY] does not assist such Third Party to identify, discover or make a Compound or Product ; a nd ( 2 ) material transfer agreements with academic collaborators or non - profit institutions solely to conduct noncommercial research . A list of Permitted Licenses as of the Effective Date is set forth on A PPENDIX 3 attached hereto