definiens: shalllmean aRibozyme directed toHER-2 unless anduntila[~Sl;ibstitute RibezymeuuJ directed toaL_~Suestiwte Tllfget_.J isdesignated tobethesubject oftheProject pursuant tothedesignation ofa~8l;ibstitute Rieezyme - l and ~ St : t&stitute Target - l under theprovisions ofClause 2.2oftheJDOA . inwhich.casethetermL~-l shallmeansuchdesignated l_·Sub9tituteRibezyme .. Jdirected tol_~the Sl : ibstiwte Target._J shallmeanacompany, corporation orpersonlistedinSchedule 2andsuccessors thereofor anyadditional broad ~ based technologicalcompetitor ofElanadded tosuchSchedule fromtimetotimeuponmutual agreementofthe Parties