definiens: means the period from the Effective Date until the earlier of : ( a ) [ EIH for the first Product ], or ( b ) the date [ three ( 3 ) years ] after the Effective Date, provided, however, if the [ Satisfactory Perfusion ] Culture Result with [ BOI89 ] is not achieved on or before [ March 31, 2006 ], and as a result, [ there is a delay in availability of GMP Product for use for GLP toxicology studies ], such [ three ( 3 ) year ] period shall be extended by a period equal to the time between [ March 31,2006 ] and the date that a [ Satisfactory Split - Batch ] Culture Result is achieved, provided, further, if any E Compound other than [ B0189 ] is selected as the Lead Compound, the foregoing [ three ( 3 ) year ] period shall be [ three ( 3 ) years ] and [ nine ( 9 ) months ]