definiens: means a sustained, continued and active commitment of efforts and resources by a Partyconsistent with those normally applied in the pharmaceutical industry with respect to compoundsor products with similar market at a similar stage in the product life cycle that such Party isactively developing or commercializing ( as applicable ), taking into account the stage and risk ofdevelopment or commercialization of the Product, issues of safety or efficacy, the costeffectiveness of efforts or resources while optimizing profitability, the competitiveness ofalternative Third Party compounds, products or generics that are or are expected to be in themarketplace, the scope and duration of Patents or other intellectual property rights related to thecompound or product ( including any Regulatory Exclusivity ), the profitability of the Product(including pricing and reimbursement status achieved or likely to be achieved ) or other relevantcommercial factors,5 [ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commissionpursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended