definiens: means : ( a ) in the case of Sangamo, the efforts and resourc es typically used by biotechnology companies similar in size and scope to Sangamo to perform the obligation at issue ; ( b ) in the case of [COMPANY], the efforts and resources typically used by [COMPANY] and its Affiliates to perf orm the obligation at issue ; in each case, which efforts shall not be less than those efforts made with respect to other products a t a similar stage of development or in a similar stage of product lif e, with similar developmental risk profiles, of sim ilar market and commercial potential, taking into account the compe titiveness of the market place, the proprietary pos ition of the products, the regulatory structure involved, the pr ofitability of the applicable products ( taking into account payments made by the Responsible Party to the other Party with respect to each Collaboration ZF Produc t under this Agreement ) and other relevant factors