definiens: means ( 1 ) licenses granted by Isis before or after the Effective Date to any Third Party under the IsisCore Technology Patents, the Isis Manufacturing and Analytical Patents, or the Isis Manufacturing and Analytical Know - How(but not under the Isis Product - Specific Patents ) to ( a ) use oligonucleotides ( or supply oligonucleotides to end users ) solely toconduct pre - clinical research, or ( b ) enable such Third Party to manufacture or formulate oligonucleotides, where ( i ) suchThird Party is primarily engaged in providing contract manufacturing or services and is not primarily engaged in drugdiscovery, development or commercialization of therapeutics ; and ( ii ) Isis does not assist such Third Party to identify, discover or make a Compound or Product ; and ( 2 ) material transfer agreements with academic collaborators or non - profitinstitutions in connection with the Isis Conducted Activities approved by [COMPANY], such approval not to be unreasonablywithheld or delayed