definiens: means, with respect to the performing Party, the allocation of a commerciallyreasonable level of personnel and financial resources towards the subject act to be attempted, taking into account scientificand commercial factors, including, if and as applicable, issues of safety and efficacy, difficulty in developing ormanufacturing the subject products, cost of and ability to manufacture the subject products in commercial quantities, comparative metrics between Deuterated Product and its Non - Deuterated Equivalent, availability or competitiveness ofalternative Third Party products, the patent or other proprietary position of a product, the existence of patents or proprietaryrights of a Third Party related to a product, the Regulatory Approval requirements involved, the existence, degree or absenceof Regulatory Exclusivity, the anticipated or approved product labeling, the potential profitability of a product, the pricing orreimbursement approvals expected to be achieved or required, and any other relevant factors typically considered for adevelopmental product