definiens: means, as of the Second Amendment Effective Date, the Santaris Agreement, UNC Agreement ( with respect to the know - how only, and notwithstanding anything to the contrary in this Agreement, Patent Rights li censed to Miragen under the UNC Agreement shall be excluded from Miragen Companion Diagnostic IP and M iragen Therapeutic IP ), and UT Southwestern Agreements . Upon the selection of a Replacement Tar get, the Parties shall amend this definition as necessary to add all additional license agreements between Miragen and a Third Party entered into befo re the Effective Date pursuant to which Miragen has a sublicenseable license to Miragen Therapeutic IP th at covers such Replacement Target or Licensed Oligos t hat directly and selectively modulate such Replacement Target . Upon the termination of a Targe t, the Parties shall amend this definition to remov e all license agreements between Miragen and a Third Part y pursuant to which Miragen has a sublicenseable license to intellectual property that is no longer Miragen Therapeutic IP because it covers a member o f the microRNA target family that was terminated or Licen sed Oligos that directly and selectively modulate such member . ” [ * ] = Certain confidential information contained in this document, marked by brackets, is filed with t he Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended