definiens: means : 1.224.1 with respect to any Collaboration Targe t, the period commencing on ( a ) the Effective Date ( with respect to any Initial Collaboration Tar get ) or ( b ) such day that a Target becomes a Collab oration Target in accordance with Section 2.2.1 ( Initial an d Replacement Targets ) ( with respect to any Replace ment Collaboration Target ) and ending on ( i ) [ * ] of the applicable License Option Effective Date ( if a Lice nse Option is exercised on any Degrader Product Directed To su ch Collaboration Target in accordance with Section 3.2 ( License Option ) ) or ( ii ) the earlier of ( x ) the la st day of the applicable License Option Period or ( y ) such day that such Collaboration Target becomes a Tabled Tar get ( in the case of sub - clause ( ii ), if no License Option is exercised on any Degrader Product Directed To such Collaboration Target in accordance with Section 3.2 ( License Option ) ) ; 1.224.2 with respect to any Tabled Target, the period commencing on such day that a Collaboration Target becomes a Tabled Target and en ding on the earlier of ( a ) the last day of the appl icable License Option Period or ( b ) such day that such Tar get becomes a Collaboration Target ; and 26 1.224.3 with respect to any Reserved Target, th e period commencing on such day that a Target becomes a Reserved Target and ending on the earlier of ( a ) the last day of the applicable Reserved Tar get Period or ( b ) such day that such Target becomes a Collabor ation Target or ceases to be a Reserved Target