definiens: means the period beginning on the Effective Date and ending on June 11, 2010, or suchlater date as the Parties may mutually agree in writing ; provided, that, ( a ) the Research Program Term ending June 11, 2010,may be extended for up to two ( 2 ) additional periods of one ( 1 ) year each upon the mutual agreement of the Parties, subject toARCHEMIX ’s commitment to continue to provide FTEs, and TAKEDA ’s commitment to continue to provide ARCHEMIXwith the R&D Funding applicable thereto pursuant to Section 5.2.1, in order to discover Optimized Lead Compounds for oneor more Program Targets ; and ( b ) if this Agreement is terminated prior to the end of the Research Program Term, the effectivedate of such early termination shall become the last day of the Research Program Term . For purposes of clarity, under nocircumstances shall the Research Program Term be extended beyond the fifth anniversary of the Effective Date