definiens: means for the ex - vivo activation and expansion of human T - cells containing ENGINEERED T - CELL RECEPTORS for use as atherapy for the TREATMENT of CANCER, INFECTIOUS DISEASE and/or AUTOIMMUNE DISEASE where such therapy comprises : ( a ) removing asample containing T - cells from a human patient ; ( b ) isolating T - cells from such sample using LTC BEAD PRODUCT or similar magnetic beads;(c ) transfecting such isolated T - cells with a gene or genes encoding ENGINEERED T - CELL RECEPTORS of known antigen specificity ; ( d ) activating andexpanding the population of such engineered T - cells using LTC BEAD PRODUCT or similar magnet beads ; and ( e ) introducing the expanded, engineeredT - cells back into the same patient for TREATMENT of such CANCER, INFECTIOUS DISEASE and/or AUTOIMMUNE DISEASE