definiens: t o read as follows : shall mean a clinical tria l designed to evaluate the pharmacokinetic and pharmacodynamic properties, maximum tolerated dose, dosing interval, and absorption, distribution, metabolism and excretion of a candidate drug . " 2 . Section 6.3 of the License Agreement is amended and restated to read in its entirety as follows : 6.3 Milestone Payments . Within [ * * * ] following the occurrence of each of the events specified below for the first Licensed Product only, SGI shal l pay to CLB the following amounts : Milestone Payment 1 . [ * * * ] [ * * * ] 2 . [ * * * ] [ * * * ] 3 . [ * * * ] [ * * * ] 4 . [ * * * ] [ * * * ] 5 . [ * * * ] [ * * * ] 3 . Section 12.1 of the License Agreement is amended and restated to read in its entirety as follows : " 12.1 The term of this Agreement shall commence as of the Effective Date and shall continue in effect until the earliest of the following : ( a ) ter mination of the Agreement by either party pursuant to Section 12.2 ; ( b ) [ * * * ] ; or ( c ) the [ * * * ] of the Fi rst Commercial Sale ( the ) ; provided, howeve r that on the [ * * * ] the License shall survive termination and become royalty - free, fully paid - up and perpetua l