definiens: means any Indication as to which a separate Drug Approval Application is requiredfor approval in a jurisdiction . By way of example, ( i ) for ophthalmology Indications, macular degeneration and diabeticretinopathy are two separate Milestone Indications, ( ii ) with respect to autoimmune disease indications, Crohn ’s disease andulcerative colitis are two separate Milestone Indications and ( iii ) with respect to cancer Indications, means a cancer of a particular organ or any metastatic progression thereof, including as distinct Milestone Indications, breastcancer, prostate cancer, colon cancer, rectal cancer, ovarian cancer, uterine cancer, gastric cancer, bladder cancer, brain cancer, bile duct cancer, pancreatic cancer, kidney cancer, stomach cancer, head - and - neck cancer, esophageal cancer, liver cancer, andlung cancer