definiens: means, with respect to CRXX ’s obligations under thi s Agreement to Develop or Commercialize a Product, the efforts and resources comparable to those undertaken by CRXX in pursuing intellectual property protection and the research, discovery or commercialization of proprietary mater ials and the development of product candidates, as applicable, t hat are not subject to the Collaboration and that a re at an equivalent stage of development or commercializatio n and have similar market potential and are at a si milar stage in their lifecycle, taking into account facto rs such as, mechanism of action ; efficacy and safet y ; product profile ; actual or anticipated Regulatory Authority approved labeling and pricing ; and the nature and extent of market exclusivity ( including patent coverage, prop rietary position and regulatory exclusivity ; cost, time required for and likelihood of obtaining Regulatory Approval ; competitiveness of alternative products and market conditions, actual or projected profitabilit y and availability of capacity to manufacture and s upply for commercial sale ), as applicable . In addition, facto rs beyond the reasonable control of CRXX, including without limitation, regulatory delays, safety findings, unf oreseen technical challenges, the failure of a Prod uct to meet necessary scientific or regulatory endpoints, and e vents described in Section 15.2 shall be taken into account