definiens: shall mean, to the extent ISTA or its Affiliate sells Product directly to health care providers, the total amount invoiced to Third Parti es in connection with the sales of the Product in t he Field by ISTA or its Affiliates or, to the extent I STA sells or distributes the Product through a lice nsee, sublicensee, distributor, agent or the like, the to tal amount invoiced by such licensee, sublicensee, distributor or agent in the [COMPANY] Territory, in either case less, to the extent actually incurred : ( a ) amounts credited or payable for damaged, outdated a nd returned products ; ( b ) trade, cost or quantity discounts earned or granted ; ( c ) transportation charges ( including insurance costs ) for outbound freight related to delivery of the Product, sales taxes, use taxes, excise taxes and d uties, and other similar charges ; ( d ) wholesaler chargebacks for the difference between w holesale acquisition cost and the current contract price with government departments, group p urchasing organizations and health plans ; and ( e ) allowances for Medicare, Medicaid and other rebates and management fees, mandated, earned or granted