definiens: means with respect to any Product Manufactured by or on behalf of [COMPANY], GSK’scosts of Manufacturing such Product, which shall be the sum of the following components : ( a ) direct costs, includingmanufacturing [ * * * ] directly used in Manufacturing such Product by [COMPANY] or its Affiliates and allocated [ * * * ] of themanufacturing department ; ( b ) [ * * * ] of non - manufacturing departments ( such as quality and regulatory ) attributable to suchProduct ; ( c ) an allocation of [ * * * ] used in Manufacture of Product ; ( d ) [ * * * ] and other charges incurred by [COMPANY] foroutsourcing the Manufacture of the Product and the cost of [ * * * ] manufacturers, and of [ * * * ] of the outsourced items, and(e ) any other [ * * * ] out - of- Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to theCompany ’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934