definiens: means licenses granted by Isis after the Effective Date to any Third Party under the Isis CoreTechnology Patents or the Isis Manufacturing and Analytical IP ( but not under the Licensed Product Patents or foruse of the [ * * ] ) to ( a ) use oligonucleotides ( or supply oligonucleotides to end users ) in quantities not to exceed [ * * ] per oligonucleotide per end user solely to conduct Pre - Clinical Research, or ( b ) enable such Third Party to [ * * ], where such Third Party is primarily engaged in providing contract manufacturing or services and is not engaged indrug discovery, development or commercialization . Notwithstanding the foregoing, Permitted Licenses do notinclude any licenses that allow ( i ) a Third Party to make, use or sell an oligonucleotide having the same [ * * ] as aProduct or Isis ’ preferred [ * * ] ; ( ii ) a Third Party to manufacture any nucleic acid that ( A ) is designed to [ * * ] apoB or(B ) acts predominantly by [ * * ] apoB, in each case ( ( A ) or ( B ) ), that will be incorporated into a therapeutic product foruse in human clinical trials or for commercial sale ; or ( iii ) Isis to directly supply to any Third Party any nucleic acidthat any nucleic acid that ( i ) is designed to [ * * ] apoB or ( ii ) acts predominantly by [ * * ] apoB