definiens: means and includes : The De velopment Alliance and Supply Agreement dated May 7, 2002 between Biosense and [COMPANY] ( the ), as amended by : ( i ) the Amendment to Development and Su pply Agreement dated November 3, 2003 ( the ) ; ( ii ) the research and deve lopment side letter between the Parties dated November 3, 2003, ( the ) ; ( iii ) th e Alliance Expansion Agreement dated May 4, 2007 ( ) ; ( iv ) four side letter s between the Parties, each dated May 4, 2007, whose subject matter was, respectively, CARTO Pro R MT, Third Party Collaboration Rights, Exclusivity and the Meaning of Customers in the Non -Localized Alliance ( collectively, the ) ; ( v ) the Second Amendment to Develop ment Alliance and Supply Agreement, dated July 18, 2008 ( the ) ; ( vi ) the Th ird Amendment to Development Alliance and Supply Agreement, dated December 8, 2009 ( the ) ; ( vii ) the Fourth Amendment to Development Alliance and Supply Agreement, effec tive as of May 1, 2010 ( ) ; and ( viii ) the Fifth Amendment to Deve lopment Alliance and Supply Agreement, effective as of August 1, 2010 ( )