definiens: with correlative meanings or to, means covalent chemical bondingof any REAGENT ( including the SELECTED REAGENT and including covalent chemical bonding through linkinggroups ) with or to another material or materials . Such materials include, without limitation, proteins, peptides, oligonucleotides, other biomolecules, small molecules, therapeutic agents ( including the THERAPEUTIC AGENT),diagnostic agents, imaging agents and detectable labels . Additional materials that may be PEGYLATED includewithout limitation, polymers, liposomes, films, chemical separation and purification surfaces, solid supports, metal / metal oxide surfaces and other surfaces such as, by way of example but not limitation, those on implanteddevices, and equipment, where a REAGENT is covalently chemically bonded to one or more reactive molecules on thesurface of such device or equipment . shall include the synthesis, derivatization, characterization, andmodification of PEG for such purposes, together with the synthesis, derivatization, characterization, and modificationof the raw materials and intermediates for the manufacture of REAGENTS ( including the SELECTED REAGENT ) orproducts ( including the SELECTED PRODUCT ) incorporating such REAGENT by means of covalent chemicalbonding, and all methods of making and using each and all of the foregoing