definiens: means the Know - How Controlled by Translate Bio or any of its Affiliates as of the Execution Date that is necessary or reasonab ly useful in the development, manufacture, sale or use of any Product in a Licensed Field that has been identifie d by Translate Bio in writing as its proprietary Kn ow - How, and the use of which by [COMPANY] ( and/or any of its A ffiliates ) to make, sell or use Products absent the licenses granted herein would constitute unauthorized use by [COMPANY] ( and/or its Affiliates ) . Schedule 1.51 ( Lic ensed Know - How ) lists in part 1 the Licensed Know - How acq uired by Translate Bio from Shire per the Shire Agreement and in part 2 Licensed Know - How independe ntly developed by Translate Bio following the Closi ng ( the terms as used in this Section 1.51 h as the meaning as defined in the Shire Agreement ) a nd prior to the Execution Date, which will be updated from time to time by Translate Bio, as appropriate . No item listed on Schedule 1.51 shall be considered Licensed Know - How hereunder until ( 1 ) Translate Bio has provided suf ficient detail in writing regarding such item ( whether thro ugh pre - read of any JSC meeting with regard to the Collaboration, the Technology and Process Transfer Plan or otherwise ) to enable [COMPANY] to determine th e identity and need for such Know - How, and ( 2 ) [COMPANY] has acce pted, by written notice to Translate Bio ( which dur ing the Collaboration Term may be through minutes of JSC me etings ), that it wishes to include such item within the licenses granted to [COMPANY] by Translate Bio pursuan t to Section 9.1