definiens: means any and all technology, information, material, and know - how, including, but not limited to inventions ( including MERCK Technology Collaboration Inventions and MERCK 's rights in Joint Technology Collaboration fuventions ), discoveries, improvements, processes, methods, protocols, formulas, data, and trade secrets, patentable or otherwise which : ( a ) as of the Effective Date and/or during the Collaboration Term, is in the Control of MERCK or ROSETTA or their wholly - owned subsidiaries, and ( b ) is necessary or useful to ALNYLAM for the Technology Collaboration and/or for in vitro andlor in vivo target identification andlor target validation including ( i ) data and methods for monitoring RNAi selectivity and potency, and ( ii ) approaches to optimal design of siRNAs, including but not limited to informatics approaches . does not include technology, information, or material, including inventions, discoveries and know - how, patentable or otherwise, relating to MERCK Non - Druggable Targets, including but not limited to MERCK RNAi Novel Target IP