definiens: means the commitment of resources and efforts consistent withthe resources and efforts generally used by such Party in the exercise of its reasonable business, legal, medical and scientificjudgment, relating to the development and commercialization of a diagnostic product owned by it or to which it has exclusiverights, with similar product characteristics, which is of similar market potential at a similar stage in its development or productlife, taking into account issues of patent coverage, safety and efficacy, product profile, the competitiveness of the marketplace, the proprietary position of the product, the regulatory structure involved, the potential or actual profitability of the applicableproducts ( including pricing and reimbursement status achieved or to be achieved ), and other relevant factors, includingtechnical, legal, scientific and/or medical factors . For purposes of clarity, Commercially Reasonable Efforts would bedetermined on a market - by - market and application - by - application basis for a product and it is anticipated that the level ofeffort may be different for different markets and may change over time, reflecting changes in the status of the applicableproduct and the market(s ) involved