definiens: means [COMPANY] 's proprietary technology for the generation of fully human monoclonal antibodies usil!¥ ( i ) any of Me dar ex 's proprietary immunizable transgenic mice that contain ~ nrearranged humar~ heavy and light ~ hain immunoglobulin transgene ~ inserted into ~ ouse chromosome ~ and which are commonly known as a HuMAb - Mouse ® ; ( ii ) any mice comprising both ( A ) human tmmunoglobulin trans gene nucleic acids]developed by [COMPANY] or otherwise developed through use of [COMPANY] 's proprietary HuMAb Mouse ; and ( B ) human[mmunoglobulin transchromosome nucleic acid ~ developed by Kirin Brewery Company, Ltd. ( ) or otherwise developed through use ofKirin 's pro ~ rietary TC Mouse ™ ( as defined below ), including, without limitation, any mouse comprising the ~ uc1eic acidsldescribed in clause ( A ) and clause ( B ) of this clause ( ii ) that is derived by ( x ) crossbreeding the & uMAb Mouse with a TC - Mouse, ( y ) introducing ~ucleic acid ~ obtained, isolated, or derived from a HuMAb Mouse into one or more cells obtained from a TC - Mouse, or ( z ) introducingfuucleic acid ~ obtained, isolated, or derived from a TC - Mouse into one or more cells obtained from a HuMAb Mouse ; and ( iii ) any progeny produced by ( or by use of ) such transgenic mice described in clauses ( i ) and ( ii ) above . For purposes of this Section 1.85, shall mean any immunizable transchomosomic DOCSPNW1:21440.6 11911 - 24 ASG -9-*ConfIcIendaI Treatment ' - .. ;.~jIl mouse developed by Kirin that contains one or more humanfhromosomes]or [ ragments]thereof ' I that include ~ entromereland ~elomereJse ~ ences that provide for replication outside of mouse [ chromosome~ and which [ chromosome ( s ~ or ~ragment ( s ~ comprises an ~nrearranged]human ( immunoglobulin locu,