definiens: means a detailed plan that sets forth the responsibilities of, and activities to beconducted by, [COMPANY] ( and [COMPANY] pursuant to Section 4.3 ) in advancing one or more Cells and/or Cell Therapies intoone or more potential Clinical Development Candidates for a particular Cardiovascular Indication ( including a detailedbudget corresponding to each such plan ) . Each such Pre - Clinical Development Plan shall include, without limitation, thefollowing activities ( or their equivalents ), to the extent applicable : ( a ) conducting research and development activities related to Cells and Cell Therapy, as a step in the ultimateobjective of identifying and characterizing Clinical Development Candidates ; and ( b ) conducting pre - clinical research, pre - clinical development and other pre - clinical studies that are intended tofacilitate and support progression of one or more Cells and/or Cell Therapies to selection as Clinical DevelopmentCandidates, and ultimately to Regulatory Approval of such Clinical Development Candidate(s ) as a Cell TherapyProduct(s);An initial draft Pre - Clinical Development Plan(s ) has been prepared by [COMPANY] and presented to [COMPANY] prior to theEffective Date . Within ninety ( 90 ) days after the Effective Date, the JSC shall finalize such draft Pre - Clinical DevelopmentPlan(s ), and such final Pre - Clinical Development Plan shall be attached hereto as Schedule 1.45