definiens: means, with respect to the research, development, Manufacture orcommercialization of a Compound or Licensed Product, as the case may be, conducting such tasks using such efforts andresources that are typically used by [COMPANY] in conducting the same tasks on its own compounds or products with similarcommercial and scientific potential at a similar stage in their lifecycle and in a similar therapeutic area, taking into considerationtheir safety and efficacy, their cost to develop, the competitiveness of alternative compounds and products and the nature andextent of their market exclusivity ( including Patent coverage and regulatory exclusivity ), the likelihood of Regulatory Approval, their expected profitability, including the amounts of marketing and promotional expenditures with respect to the LicensedProducts and Generic Products, and all other factors that are typically taken into consideration by [COMPANY] when determiningthe level of efforts and resources to apply to such tasks with respect to its own similar compounds or products ( as describedabove )