definiens: shall mean the clinical and non - clinical criteria to be established by the Joint ProgramSubcommittee, subject to the agreement of the JSC and the final approval of [COMPANY], to establish proof of concept for agiven Development Candidate through the PoC Trial in a Program . The PoC Criteria shall set forth : ( a ) the [ ... * * * ... ] andrelevant [ ... * * * ... ] for the PoC Trial 19***Confidential Treatment Requestedin such a manner that, following the PoC Trial, a determination can reasonably be made that such [ ... * * * ... ] ; ( b ) wherereasonable and appropriate, a [ ... * * * ... ] ; ( c ) appropriate and validated [ ... * * * ... ] ( d ) [ ... * * * ... ] ( i ) which is appropriate [ ... * * * ... ] asto which there is no[ ... *** ... ]which would prevent the compound from being developed into a [ ... * * * ... ] ( i.e., there is no knownimpediment which would render [ ... * * * ... ] the [ ... * * * ... ] ) and ( ii ) that show [ ... * * * ... ] safety and tolerability profile in view ofrelevant clinical and regulatory considerations ; ( e ) a [ ... * * * ... ] which is in a [ ... * * * ... ] that is suitable for [ ... * * * ... ] ( i.e., there isno known impediment which would render [ ... * * * ... ] ) ; ( f ) a [ ... * * * ... ] taking into account suitable [ ... * * * ... ] who could run such [ ... * * * ... ], any such contractors to be agreed by the JSC are understood and controlled [ ... * * * ... ] is reasonable for suchindication ; and ( g ) a [ ... * * * ... ] that is consistent with the applicable Target Product Profile