definiens: means, with respect to Ac tive Pharmaceutical Ingredient, the actual fully allocated cost of manufacturing such Active Pharmac eutical Ingredient calculated in accordance with GA AP or appropriate accounting principles similar to GAAP, which consists of ( i ) the direct cost of any raw ma terials, intermediates, packaging materials and labour ( incl uding benefits ) utilized in such manufacturing ( inc luding filling, finishing, quality control and stability t esting, labelling and packaging, as applicable ), ( i i ) an appropriate share of factory overhead allocated to the Active P harmaceutical Ingredient being manufactured, ( iii ) handling charges like transportation costs and insurance rel ated thereto and ( iv ) the net cost or credit of any value - added taxes actually paid or utilized by such Party or Af filiate in respect of the manufacture of the Active Pharmaceutical Ingredient . It is understood and agr eed that in the case of Active Pharmaceutical Ingre dient manufactured by Third Parties, Cost of Goods Sold m eans such payments made to such * * CERTAIN INFORMATION ( INDICATED BY ASTERISKS ) HAS BEEN OMITTED FROM THIS DOCUMENT PURSUANT TO A CONFIDENTIAL TREATMENT REQUE ST . AN UNREDACTED VERSION OF THIS DOCUMENT HAS BEEN FILED WITH THE SE CURITIES AND EXCHANGE COMMISSION