definiens: for these purposes means the power of a person to secure : ( i ) by means of holding shares or the possession of voting power in or in relation to that or any other LAXDALE LTD . KaNGS PARK HOUSIi, LAuR!LHJLL BlJSIJt«ESS PAR~ POLMAISE ROAD . STJRUNG . UK FK7 9JQ TEI.:+44 ( 0)1786476000 FAX:+44 ( 0)1786 473131 E -- MAn . : admin@,Q)Cdale.co.uk I\EGlmRa ) IN Sc : olIANO No . 179838 ~ OFflc:£ KINGS Pm House, L.AuRaHiLL BUSlNIiSS Pm . Pcuwse ROAD . S11J\LING . UJ ( FK7 9JQ Received Mar-1S - OS 03:10am From- To - or Cahill Gordan I R Pale 002 1 5 . Mar. ~O 0 6 1 0 . : 03 • I 2 Bffective DateBMEAField of UseGroup CompanyMajor Improvement " Sci ) -Licence & : Disttibucion Final26~ Marcb 2003 Received Mar-15 - 06 03:10am From - No.2233 p. 3/22 PRIVATE~ body corporate ; or CONFIDENTIAL ( ii ) by virtue of any powers conferred by the articles of association or other document regulating that or any other body corporate that the affairs of the first mentioned body oorporate are eOJlducted in accordance with the wishes of that person ; means the cost incurred by [COMPANY] in relation to a Unit SUpplied on to Seil pursuant to Purchase Orders ; means the last date of signature hereof by or on behalf of each of the parties hereto by persons duly and expressly authorised ; means the Buropean Agency for the Evaluation of Medical Products or such successor or replacement body as may from time to time supersede it ; means the marketing, distribution and Sale of Licensed Product for the therapeutic treatment and/or prevention of Huntingron 's Disease it being acknowledged that in the event Lndale, in its sole discretion, widens the development of the Licensed Product to include the treatment of Spino­cerebellar atrophy ; Progressive Supranuclear Palsy ; Fragile X and Friedreich ' s ataxia these treatments shall be included in this defmition of Field of Use for the pUlposes of this Agreement . To avoid any doubt [COMPANY] shall be lDlder DO obligation to widen the scope of the development as aforesaid ; Means any company which is for the time being a subsidiaIy or holding company of Seil or any subsidiary of such holding company ; means all improvements or modifications or adaptations to the Licensed Product within the Field of Use which may be made or acquired by [COMPANY] during the Term ( as after defined ) ; means all improvements or modifications or adaptations to the Licensed Product by [COMPANY] which would render the Licensed Product to be considered by the relevant regulatory authority as a new and separate Licensed Product and which ( a ) obtains it 's own orphan drug designation and ( b ) requires completion of a clinical program for it 's ~ ~~h To-07 Cahill Gordon I R Pale 003 15 · Ma r · 2·006 1 0 ~ 03 :