definiens: means, with respect to each country of the world, the gross amount invoiced271 by SPRI, or its Affiliates or sublicensees, on sales of a Collaboration Producl.to a Third Party end user,272 and exclusive of intercompany transfers or sales, less the actually granted or incurred reasonable and clls-273 tomary deductions from such gross amounts including : ( i ) normal and customary trade, cash and quantity274 discounis, allowances and credits ; ( ii ) credits or allowances for damaged goods, returns or rejections and275 re!roactive price reductions ; ( iii ) sales or similar taxes ( including duties or other governmental charges276 levied on, absorbed or otherwise imposed including without limitation value added taxes or other gov-277 emmental charges otherwise measured by the billing amount, when included in billing ) ; ( iv ) freight, post-278 age, shipping, customs duties and insurance charges ; ( v ) charge back payments and rebates ( or equiva-279 lents thereol ) granted to managed health care organizations or to federal, state and local governments,280 their agencies, and purchasers and reimbursers or to trade customers, including but ootlimited to, whole-281 salers and chain and phannacy buying groups ; and ( vi ) commissions paid to Third Parties other than sales282 .personnel and sales representatives or sales agcnts