definiens: or means ( a ) with respect to the manner by whichARCHEMIX performs ( i ) the activities assigned to ARCHEMIX in the Research Program and ( ii ) ARCHEMIX AdditionalActivities, if any, efforts and resources that are comparable to those undertaken by ARCHEMIX in pursuing the research, discovery, development and intellectual property protection of proprietary materials and the development of productcandidates, as applicable, that are not subject to the Collaboration and that are at an equivalent stage of research, developmentor commercialization and have similar market potential and are at a similar stage in their lifecycle, and ( b ) with respect toactivities of TAKEDA in the Research Program, and the Development and/or Commercialization of a particular Product, theefforts and resources comparable to those undertaken by TAKEDA in pursuing intellectual property protection, developmentand commercialization of similar products that are not subject to the Collaboration, taking into account the product ’s stage ofdevelopment and/or commercialization, risks and probabilities of success, market potential, and stage in their lifecycle . Forpurposes of ( a ) and ( b ) above, all relevant factors as measured by the facts and circumstances at the time such efforts are dueshall be taken into account, including, as applicable and without limitation, mechanism of action ; efficacy and safety ; productprofile ; actual or anticipated Regulatory Authority approved labelling ; and the nature and extent of market exclusivity(including patent coverage, proprietary position and regulatory exclusivity ; cost, time required for and likelihood ofobtaining Commercialization Regulatory Approval ; competitiveness of alternative products and market conditions ; actual orprojected profitability and availability of capacity to manufacture and supply for commercial sale )