definiens: means any analogues and/or derivatives of Irofulv en owned and/or controlled by LP either prior to or during the Term of the Agreement, which analogues and/or derivativ es have the same or similar mechanism - of - action as Iro fulven but are characterized by substantially diffe rent and/or superior anti - tumor activity and/or safety / t oxicity profile as compared to Irofulven ( e.g. by I C50 and other standard cellular and animal testing mode ls ), including analogue LP-184, currently under development by LP, but excluding all of the followi ng : illudin bound directly or via a linker to a Con jugate or acylfulvene bound directly or via a linker to a Conjugate, including an illudin analogue bound dire ctly or via a linker to a Conjugate, acylfulvene analogu e bound directly or via a linker to a Conjugate, Ir ofulven bound directly or via a linker to a Conjugate or Ir ofulven Analogue bound directly or via a linker to a Conjugate