definiens: means all Know - How that ( a ) is Controlled by AVEOas of the Effective Date of this Agreement or thereafter during the Term, and ( b ) is necessary orreasonably useful in the research, development, manufacture and commercialization of anyLicensed Compound, Licensed Product, or method of using ( including methods of administration)or testing any of the foregoing ( or any article necessary or useful to practice any such method)including but not limited to all Clinical Regulatory Filings, Safety Data and CMC data related tosuch Know - How Controlled by AVEO after the Effective Date, but excluding any Know - How in - licensed by AVEO after the Effective Date for which AVEO would owe a Third Partyconsideration if AVEO grants rights thereunder to Partner ( unless Partner agrees in writing to paysuch consideration ), and further subject to the limited use of data from AVEO ’s IndependentStudies prior to Opt - In as described in Section 2.2(c )