definiens: shall mean any pharmaceutically active agent wh.i ~ h ( a ) consists of nucleic acid or a functional analog . derivative or homC:~9 g .!h.~! .. ~?f)hatl · nco es I a Isease Gene or a part thereoT or ( ii ) a geneora -- parnhereoTthat encodes another member of a Biological Pat a of whO I')_Jb~.J ~ LQ9uct of a Disease Gene is a member and -(b u on e Ivery by any means . compensates . either completely or partla y. for the genetic defect that underlies the Selected Disease the pathogenesis of which is affected by the Disease Gene . and ( c ) is conceived and reduced to practice as a result a Research Program by a Party . its Affiliate or its Collah ~ r.::ltnr at anv time during a Dp.rind commencinq on the Effective Date and ending five ( 5 ) years after a first, Validated Target - has - been obtained tor The Selected Disease the pathogenesis of which is affected by the Disease Gene