definiens: shall mean those incremental additional payments to be made by [COMPANY] to a provider of LNP Technology other than under the Acuitas License or Arcturus License resulting from the decision by [COMPANY] to switch from the First Collaboration Target to a Replacement Target, including payment of additional license or reservation fees and/or increased royalties because a new license of LNP Technology is required other than the Arcturus License or Acuitas License . For clarity, the term shall only comprise the delta between what [COMPANY] would have had to pay to Arcturus under the Arcturus License or to Acuitas under the Acuitas License for an LNP Technology license relating to the First Collaboration Target and what [COMPANY] will h ave to pay to a provider of LNP Technology other than under the Acuitas License or Arcturus License for an LNP Technology license relating to the Replacement Target . The Switching Costs shall be determined from time to time when any payment relating to the Replacement Target is due under such LNP Technology license other than Acuitas License or Arcturus License by comparing the actual total payments made or due under such other LNP Technology license with the payments that would have been made by or due fro m [COMPANY] under the Arcturus License or Acuitas License with respect to the given Product . Whether the Arcturus License or Acuitas License will be used as reference point when making such calculations of the then current total Switching Costs will depend o n which of the two LNP Technologies that were used for Product based on the First Program Antibody