definiens: shall mean the performance of obligations or tasks normally used bya biotechnology company of similar size to Licensee in the exercise of its reasonable discretion relating to thedevelopment or commercialization of a product, in each case owned by it or to which it has exclusive rights, havingsimilar technical and regulatory factors and similar market potential, profit potential and strategic value, and that is ata similar stage in its development or product life cycle as the Licensed Product, taking into account issues of patentcoverage, safety and efficacy, product profile, competiveness of the marketplace, proprietary position, and profitability(including pricing and reimbursement ) . Commercially Reasonable Efforts requires that the Party ( a ) promptly assignresponsibility for such obligations to specific employees who are held accountable for progress and monitoring suchprogress on an ongoing basis, ( b ) set and consistently seek to achieve specific and 3 meaningful objectives for carrying out such obligations, and ( c ) consistently make and implement decisions andallocate adequate resources designed to advance progress with respect to such obligations