definiens: . The expression means that the user 's up - front license fee has been paid . ABI grants rights to thermal cycler manufacturers to include the Authorization with their thermal cyclers, and to permit manufacturers to sell their instruments for PCR and to promote their instruments as . Under the terms of ABI 's license, manufacturers who pay the fee do not induce infringement by promoting and advertising their instruments for PCR, selling to PCR users and supporting such use . In addition, ABI owns patents that disclose and claim PCR thermal cycler apparatus, automated methods for performing PCR in thermal cyclers, and systems comprising thermal cyclers loaded with PCR reagents and programmed to perform a PCR protocol . A number of these patents have issued to [COMPANY] in Europe, the U.S. and elsewhere in the world . The running - royalty component of the PCR license required for a user to perform internal research and development activities is obtained through the user 's purchase and use of thermostable polymerase purchased from a manufacturer licensed by Roche to sell such polymerase . The rights under this component of this license are conveyed generally through a label license accompanying the polymerase