definiens: means a full - time equivalent rson- ( asSu~ & a 2,'08o - h ~ e- ~iQ1 nSL)c;eekday holidays, vacation, medical leave or other paid time o .. ' orScientific, medical, technical, regula - tory or managerial work onorififecny related to R&D-';-Ian activities or Manufacturing Plan aciivities, asapplicable, calculated on a calendar monthly fraetioQaI effort basis for each individual engaged in suchactivities . The fraction of an FTE attributable to an individual 's scientific, medical, technical, regulatoryor managerial work on or directly related to such activities in any given calendar month shall be deter - mined as follows : ( a ) the numerator of such fraction shall equal the actual hours worked by such individ - ual on or directly related to R&D Plan activities or Manufacturing Plan activities, as applicable ( whichnumber of hours shall be adjusted on a pro - rata basis in the case of exempt employees, to the extent nec - essary, such that the individual in question is not in any case allocating more of his or her time in suchcalendar month than there are total in such month to ( i ) R&D Plan activitiesand Manufacturing Plan activities, ( ii ) working activities other than R&D Plan activities and Manufactur - ing Plan activities ( e.g., work on other projects, administrative duties, and other working activities notallocable to the Collaboration ) and ( ill ) weekday holidays, vacation, medical leave and other paid - time - off, collectively ), and ( b ) the denominator of such fraction shall ~wo thousand el : ty&,~~~ours .. : : The numerator shall exclude paid - time-<Jf [ and administrative and other non - aIloca lrV . For pur - poses of the foregoing, for a given calendar month shall be equal to e totalnumber of weekdays ( including weekday holidays ) in such calendar month multiplied by ) eight ( 8)hours