definiens: shall mean ( i ) Metasyn 's cost of materials, including costs payable by Metasyn to third parties relating to production of the Licensed Compound and/or Licensed Product, and ( ii ) Metasyn 's direct labor costs incurred in the manufacture of the Licensed Compound and/or Licensed Product supplied by Metasyn . DRL shall periodically submit to Metasyn orders for the quantities of the Licensed Compound and its corresponding Licensed Product needed by DRL during the Development Phase . Each purchase order shall specify the quantities of Licensed Compound and/or Licensed Product ordered and the date by which delivery is reasonably requested . DRL shall pay fifty percent ( 50 % ) of the estimated Direct Cost for the order upon submission of each purchase order and shall pay the balance upon receipt of the vials of Licensed Compound and/or Licensed Product . Upon DRL 's request from time to time, Metasyn shall furnish to DRL reasonable supporting data for Metasyn 's calculation of the Direct Cost for any Licensed Compound or Licensed Product