definiens: means:(a ) the patents and patent applications listed on Exhibit A;(b ) any substitutions, divisionals, continuations, continuations - in - part, provisional applications, reissues, renewals, registrations, confirmations, re - examinations, extensions, supplementary protection certificatesand the like of any patents or patent applications set forth on Exhibit A;(c ) foreign counterparts of any of the foregoing in clause ( a ) or ( b ) ; and(d ) Patents other than those included in the foregoing clauses ( a ) through ( c ) that are Controlled byEPIZYME as of the Prior Agreement Effective Date or at any time thereafter prior to the expiration of the TargetExclusivity Period and arise outside of the Collaboration, that claim or are directed to EPIZYME Know - How, butexpressly excluding any Patent that claims or is directed to the composition of matter of any compound or moleculethat is not a Compound directed to EZH2