definiens: means : ( i ) [ any composition of matter, including, but not limited to, chemical entities, pro - drugs, isomers, polymorphs, peptides, non - peptides, natural products and monoclonal antibodies, ] that are discovered, synthesized or acquired ( to the extent such composition of matter is not encumbered at the time of its acquisition ) by 3DP or [COMPANY] during the Research Term, and up until [ twelve ( 12 ) months ] after the end ofthe Research Term including, but not limited to, [ compositions of matter discovered, synthesized or acquired by 3DP or [COMPANY] prior to the Execution Date ofthis Agreement, and that directly inhibits human thrombin and has a Ki of ~ 100 nM in a chromogenic substrate hydrolysis assay for inhibition of thrombin, and selectivity as a thrombin inhibitor in that the Ki for thrombin is at least ten fold ( lOx ) less than the Ki for urokinase ] ; and ( ii ) [ any compositions of matter contained within the chemical genus as defined by a claim in any 3DP Patent, [COMPANY] Patent or jointly owned Program Patent, which genus contains at least one compound from ( i ) above, unless 3DP subsequently demonstrates that such composition of matter contained within the chemical genus does not meet the requirements of ( i ) above in which case said composition of matter contained within the chemical genus will not be considered to be a Direct Thrombin Inhibitor . ] [ The composition referred to by 3DP as 3DP-4815 ( hereinafter referred to as ) shall be considered to be a Direct Thrombin Inhibitor . A composition also shall be considered to be a Direct Thrombin Inhibitor, even if it has other biological activity and is therefore a mixed inhibitor, so long as it meets the foregoing criteria for a Direct Thrombin Inhibitor . ] 1.19 means the legal currency of the United States