definiens: means any Patent claiming or covering any invention which was first conceived by either Party under an Fcab Discovery Program ( as defined in the Denali License Agreement ) and/or a mAb2 Development Plan ( as defined in the Denali License Agreement ) and/or Technical Development ( whenever it was undertaken ) which claims or covers ( i ) improvements, modifications and enhancements to the inventions claimed ( either in issued claims or pending claims ) in the F -star Patents that exist as of the Effective Date, and such improvements, modifications and enhancements are covered by the claims ( either in issued claims or pending claims ) of the F -star Patents that exist as of the Effective Date ( ii ) [ * * * ] ( iii ) [ * * * ] and ( iv ) [ * * * ] provided always that Platform Patents do not include any Patent which specifically claims or covers ( a ) the amino acid sequence of the antigen binding site and Fcab con stant domain wherein such antigen binding site sequence confers specific binding of the Fcab to an Accepted Fcab Target or ( b ) the use of an Antibody and its sequence which has a binding site in a constant domain wherein such sequence confers specific bind ing of the constant domain to an Accepted Fcab Target or ( c ) the manufacture or formulation ( or methods of manufacture or formulation ) of an Antibody and its sequence which has a binding site in a constant domain wherein such sequence confers specific bind ing of the constant domain to an Accepted Fcab Target or ( d ) the modification of a native binding site within binding loops to a native antigen [ * * * ] . For avoidance of doubt, after the expiration of the Buyout Option Period, if Denali has not exercised the Buy - out Option, then F -star and Gamma may amend this Section provided such amendment does not impair the value of the license granted by Gamma to Denali under the Denali License Agreement