definiens: means, with respect to any Compound or Product, that level of effort and resourcescommonly dedicated in the pharmaceutical industry by a biotechnology company similarly situated to Company, to the Manufacture, Development or Commercialization, as the case may be, of a product of similar commercial potential at a similar stage in its lifecycle tosuch Compound or Product, in each case taking into account the following considerations ( the ): issues of safety andefficacy, product profile, the proprietary position, the then current competitive environment and the likely timing of market entry, theregulatory environment and status of such Product, profitability, and other relevant scientific, technical and commercial factors, but withoutregard to any payments owed to [COMPANY] under this Agreement . Without limiting or derogating from the foregoing, Commercially ReasonableEfforts requires that, taking into account the CRE Considerations, Company : ( a ) promptly assign responsibility for the applicableDevelopment and Commercialization activities to specific employees who are held accountable for progress and monitor such progress onan on - going basis, ( b ) set and consistently seek to achieve specific and meaningful objectives and timelines for carrying out suchDevelopment and Commercialization activities, and ( c ) consistently make and implement decisions and allocate resources designed toadvance progress with respect to such objectives and timelines