definiens: means, for the Gd Produet or the Spray Product, as the case may be, $ 5.60, per linit of ~uch ProolJC\, to be adjusleu beginning with the Calendar YeM commencing January 1, 2004 ( i ) annually, immediately following rcleas ~ of the Producer Price Index­Pharmaceutical Preparations ( codc PCU 2834 ), as published in the U.S. Department ofT, abor, Bureau of 1, abor Stati ~ tics, to increa<;e the fixed direct labor co ~ b or ~ ill included in the cost per Unit of Product by the product of ( x ) Sl.12.}lnd ( y ) the cumulative percentage increase in ~uch in < le : < : between tile mo ~ t recent Calendar Year for which such data is available and the Calendar Year commencing January 1, 2002 and ending December 31, 2002 ( the ) ; and ( ii ) upon receipt of cach Purchase Order, by the amOlUlt of any inerea>;t :, in the per Unit cost to Seller of the raw materials included in the subjeetlJnit~ ( ) v ~ r th~ C05 t of those applicable to the raW materials inelu < le < l in lhe Units pnxluc ~ d in Sell ~ r 's last production lUn immediat ely preceding the Effective Date . For the avoidanc e of doubt, the Parties agree that in no event shall the Purchase Price be adjusted to reflect any decreases in cither ( x ) the direct labor costs included in the cost per Unit of Product or ( y ) the co ~ t of raw mlllenll)s included in the ~ubjed Unit'i