definiens: means effort, expertise and resources normally us ed by the Party in the development and/or commercializati on of a comparable 3 pharmaceutical product owned by such Party ( or to w hich it has rights ) which is of similar market pote ntial at a similar stage of development or commercialization i n light of issues of safety and efficacy, product p rofile, the competitiveness of the marketplace, the proprietary position of the compound, Antibody or product, the regulatory pathway involved for approval, the profi tability of the applicable products ( including any payments required under this Agreement ), product reimburseme nt, proprietary position, and other relevant strate gic and commercial factors normally considered by the Party in making product portfolio decisions . For purpose s of clarity, Commercially Reasonable Efforts will be de termined on a country - by - country basis within the T erritory, and it is anticipated that the level of effort may be different for different countries and may change over time, reflecting changes in the status of the Product and the country(ies ) involved