definiens: means any event, change, fact, condition, circumstance or occurrence thathas had or would reasonably be expected to have a material adverse effect on TYSABRI sales or on the TransferredAssets, taken as a whole, including as a result of safety or regulatory matters ; provided, however, that no event, change, fact, condition, circumstance or occurrence ( by itself or when aggregated or taken together with any and all other events, changes, facts, conditions, circumstances or occurrences ) directly or indirectly resulting from or arising out of any of thefollowing shall be deemed to be or constitute a or be taken into account whendetermining whether a has occurred or may, would or could occur : ( i ) conditions(or changes after the Execution Date in such conditions ) in the industry in which the Parties operate ; ( ii ) generaleconomic conditions or conditions in the securities markets, credit markets, currency markets or other financial markets(or changes after the Execution Date in such conditions ) with the United States or any other country ; ( iii ) politicalconditions ( or changes after the Execution Date in such conditions ) in the United States or any other country;(iv ) earthquakes or other natural disasters and other force majeure events in the United States or any other country;(v ) the announcement of this Agreement and the Transactions ; ( vi ) the taking of any action required or contemplated bythis Agreement, 17CONFIDENTIAL INFORMATION OMITTED AND FILED SEPARATELYWITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO A REQUESTFOR CONFIDENTIAL TREATMENT PURSUANT TO RULE 24B-2 UNDER THE SECURITIESEXCHANGE ACT OF 1934, AS AMENDED