definiens: means all technical information and know - how, inc luding inventions, discoveries, trade secrets, specifications, instructions, proces ses, formulae, expertise, materials, methods, proto cols and other technology applicable to formulations, compositions or products or to their manufacture, development, registration, use or marketing or processes for the ir manufacture, formulations containing them or com positions incorporating or comprising them, and including all biological, chemical, pharmacological, biochemical, toxicological, pharmaceutical, physical and analyti cal, safety, quality control, manufacturing, precli nical and clinical data, instructions, processes, formula, an d expertise owned or controlled by [COMPANY], or any of its contracted sublicensees, subcontractors, distributors, develop ment partners, manufacturing suppliers and other Th ird Parties, as of the effective date of this Agreement that are necessary or useful for the development or commerc ialization of the Products, including the Know - How at one time held by Aradigm Corporation ( excluding Excluded As sets, as defined in the Asset Purchase Agreement )