definiens: means with respect to each Licensed Product, the first sale for which revenue has beenrecognized by CELGENE or its Affiliates or Sublicensees for use or consumption by the general public of such LicensedProduct in any country in the CELGENE Territory for which all Regulatory Approvals and pricing or reimbursementapprovals that are legally required in order to sell such Licensed Product in such country have been granted ; in each caseprovided however that the following shall not constitute a First Commercial Sale : - 9 -(a ) any sale to an Affiliate or Sublicensee unless the Affiliate or Sublicensee is the last entity in thedistribution chain of the Licensed Product;(b ) any use of such Licensed Product in Clinical Trials ( including post - Regulatory Approval clinical trials),non - clinical Development activities or other Development activities with respect to such Licensed Product by or on behalf ofa Party, or disposal or transfer of Licensed Products for a bona fide charitable purpose ; and(c ) compassionate use