definiens: means use of the Licensed Processes and Methods, including without limitation, the SELEXProcess, the Licensed Know - How, the inventions claimed in the Licensed Patents, any Aptamers and any Licensed Products, asapplicable, for any and all purposes for which exclusive rights have not been granted to Third Parties under the PreexistingAgreements, including without limitation ( a ) the [ * * * ], ( b ) any [ * * * ], and ( c ) Target Validation and other drug developmentand research purposes, including [ * * * ], but specifically excluding ( x ) use in any In Vitro Diagnostics application, ( y ) use ofany Excluded Aptamers, or ( z ) any purpose for which exclusive rights have been granted to Third Parties under the PreexistingAgreements ; provided however, that in the event that Third Parties to no longer have rights pursuant to a PreexistingAgreement in any field, or the scope of the licenses granted therein is reduced, then the Licensed Field shall be automaticallyextended, without further action by the Parties, to include the uses or fields in which Third Parties no longer have rights, orthe uses or fields removed from the Preexisting Agreement as a result of the reduction of the scope of the licenses grantedtherein, provided that ( i ) nothing in this Section 1.18 shall give Company any rights to or interest in any products developedby or licensed to any Third Party to any Preexisting Agreement that are in clinical development, submitted for regulatoryapproval or being commercialized and ( ii ) nothing in this Section 1.18 shall give Company any rights to or interest in anyAptamer directed to [ * * * ]