definiens: means any change or effect that is materially adverse to NicVAX or the Development orCommercialization thereof, taken as a whole, but shall exclude any change, effect or circumstance resulting or arising from:(a ) events, circumstances, changes or effects that generally affect the industries in which Nabi Develops and Manufactures(including the pharmaceutical or biopharmaceutical industries ) NicVAX ( including legal and regulatory changes ), ( b ) generaleconomic or political conditions or events, circumstances, changes or effects affecting the securities markets generally,(c ) changes caused by a material worsening of current conditions caused by acts of terrorism or war ( whether or not declared)occurring after the date hereof, [ * ] Certain confidential information contained in this document, marked with an asterisk in brackets, has been omitted andfiled separately with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of1934, as amended