definiens: means Patents Controlled by [COMPANY] or its Affiliates ( in each, case other than as a result of thelicenses granted by Regulus to [COMPANY] hereunder ) that claim:(i ) [ … * * * … ] ; and(ii ) either:(a ) microRNA Compounds in general;(b ) chemistry or delivery technology useful in connection with microRNA Compounds;(c ) general mechanisms of action by which a microRNA Compound modulates microRNA ; or(d ) general methods of treating or preventing an Indication by modulating one or more microRNAs;provided, however, that in each case, [COMPANY] Blocking Patents exclude Patents Controlled by [COMPANY] or its Affiliates ( in each, case other than as a result of the licenses granted by Regulus to [COMPANY] hereunder ) to the extent that such Patents claim:(1 ) a microRNA sequence or a portion thereof;(2 ) the specific compositions of matter of any microRNA Compound being developed by [COMPANY], its Affiliateor any Third Party under license from [COMPANY] ; or(3 ) methods of using as a therapeutic any microRNA Compound being developed by [COMPANY], its Affiliate orany Third Party under license from [COMPANY]