definiens: means any Cognitive Impairment that : ( a ) is not otherwise a PrimaryIndication and is not a Small Market Indication ; ( b ) is specifically caused by or associated with a separately definedand widely recognized disease or condition ; ( c ) is, as of the Execution Date, neither included in DSM - IV or ICD-10 norrecognized as a distinct diagnosable condition by general consensus in the medical community in the United Statesor Europe, and for which no product has received Product Regulatory Approval from the FDA in the United States orthe EMEA in Europe prior to the Execution Date ; ( d ) either becomes included in DSM - IV, ICD-10 or any otherDiagnostic Manual in any Major Market Country during the Term, becomes recognized as a distinct diagnosablecondition by general consensus in the applicable medical community in any Major Market Country during the Term orfor which a product receives Product Regulatory Approval from the applicable Regulatory Authority in any MajorMarket Country during the Term ; and ( e ) [ * * * * * * * * ] as an Associated Cognitive Impairment . For purposes of clarity, theseparately defined and widely recognized disease or condition shall not itself be an Associated Cognitive Impairment