definiens: means the protein known as Akt or any of its isoforms including, without limitation, Ald - l ( Swiss - Prot # P31749 ), Akt-2 ( Swiss - Prot # P31751 ) and Akt-3 ( Swiss - Prot # Q9Y243 ), and any orthologues, or deletion aI, substitutional aodJor insertional vari ~ ts, or fragments of any of the foregoing that may be used as a surrogate for Akt or any of its isoforms in the Research Program ; provided, however, inclusion of such surrogates shall be subject to the consent of both Parties, which consent shall not be unreasonably withheld . ] or or the like, means, that the Joint Research Committee has made a particular decision ( in the context of the reference ), and that such decision is reflected in minutes of a IRC meeting that have been formally approved by both [COMPANY] and [COMPANY]