definiens: means, with respect to any objective, those reasonable, diligent, and good faith efforts to accomplish such objective as a Party would customarily use to accomplish a similar objective under similar circumstances, which are no less than those efforts used by such Party in its Development, Manufacture, or Commerc ialization projects as the case may be with such Party ’s own products and technologies having comparable commercial potential, stage of development, medical / scientific, technical, regulatory profile, and intellectual property protection, and further taking into account all Commercially Relevant Factors at the time such efforts are to be expended . To the extent that a Party ’s performance of its obligations hereunder is adversely affected by the other Party ’s failure to perform its obligations under this Agre ement or the Manufacture and Supply Agreement referenced in Section 7.1 then the impact of such performance failure by the other Party will be taken into account in determining whether that Party has used its Commercially Reasonable Efforts to perform any such affected obligations, but only to the extent such other Party ’s performance failure is the cause of that Party ’s failure to meet such obligations