definiens: means any Know - How and Patents relating to the composition ofmatter, properties, use, or manufacture of Active Moieties, proteins, peptides, nucleotide - based molecules or smallmolecules which Know - How and Patents in each case ( a ) owned, licensed, or controlled by Naia or an Aﬃliate thereof and(b ) in the case of Know - How, exists as of and/or was conceived prior to the Original License Eﬀective Date, or is developed or obtained by Naia or anAﬃliate thereof independently of the Agreement without the use of Amunix ’s Conﬁdential Information, and in the case ofPatents, claims or discloses inventions conceived prior to the Original License Eﬀective Date or developed by Naiaindependently of the Agreement without the use of Amunix ’s Conﬁdential Information, or were obtained by Naiaindependently of the Agreement after the Original License Eﬀective Date, and in each case all Intellectual Property relatedto such Know - How and Patents