definiens: means, collectively, the following clinical studies that have been completed or terminated prior tothe Effective Date : ( a ) “ Clinical Trial to Test the Safety and Effectiveness of an Investigational Drug CHR-2797 WithErlotinib in Patients With Locally Advanced or Metastatic Non - small Cell Lung Cancer ”, NCT00522938 [ Terminated – PoorRecruitment ], ( b ), NCT00692354 [ Completed],(c ) “ A Study of the Safety and Tolerability of the Addition of CHR-2797 to Paclitaxel in Patients With Advanced orRefractory Tumours ”, NCT00737555 [ Completed ], and ( d ) “ A Phase I - II Study to Evaluate the Safety, Tolerability and Anti - Disease Activity of the Aminopeptidase Inhibitor, CHR-2797, in Elderly and/or Treatment Refractory Patients with AcuteMyeloid Leukaemia or Multiple Myeloma ”, NCT00689000 [ Completed ]