definiens: means the projcctlmderway as orthe Effective Date of the Second Amendment, between Onyx and [ Synteni ( a subsidiary of Incyte Phannaeeutieals ) ] to identify [ genes whose mRNA expression level ] is specifically [ modulated ( overexpress ed or repressed)1 in response to the presence or an [ ind ~ ible DI2 mutant allele of the K - ras gene ( K - rasD12 ) ] in human tissue culture cell lines as d ~ tcrmined under [ induced or uninduced ] conditions . Such cell lines shall include the [ human colon adenocarcinoma ] ccillines [ DK04 ( K - rasDI2 allele knock - out derivative of human OLD - I ] cell line ) and [ HKE3 ( K - rasDI2 allele lmoek - out derivative of human HCT116 ] cell line ) . Tn this project . these [ mRNA expression profiles ] are being compared to those obtained from analysis of ! he [ mRNA expression profile of the parental DLD - l and HCTl16 human colon adenocarcinoma ] ec1llines . This projcct will be limited to the identity or those [ genes1 represented on the [ eDNA mlcmarray genechips . ] ' available from [ S ~ mt eni ]