definiens: shall mean such level of efforts required to carry out such obligation in a manner consistent with the efforts that a pharmaceu tical company comparable with Pieris would devote at the same stage of development or commercialization, as applicable, for its own internally developed therap eutic products in a similar area with similar marke t potential, at a similar stage of their product life taking into account the existence of other competi tive products in the market place or under development, the proprietary position of the product, the regula tory structure involved, intellectual property considera tions, the anticipated profitability of the product and other relevant factors . It is understood that such produc t potential may change from time to time based upon changing scientific, business and marketing and ret urn on investment considerations . For avoidance of any doubt, Commercially Reasonably Efforts do not requi re Pieris to seek to market any therapeutic product in every country or seek to obtain regulatory approval in every country or for every potential indication