definiens: means with respect to EPIZYME or CELGENE, as applicable, suchefforts that are consistent with the efforts and resources then used by EPIZYME or PARENT, as applicable, in theexercise of its commercially reasonable practices relating to the research, Development ( including seeking RegulatoryApproval ), Manufacture and Commercialization of a pharmaceutical product at a similar stage in its research, Development or commercial product life as the relevant Compound ( including - 5 -Licensed Compound ) or Licensed Product, and that has commercial and market potential similar to the relevantCompound ( including Licensed Compound ) or Licensed Product, taking into account issues of intellectual propertyscope, subject matter and coverage, safety and efficacy, product profile, competitiveness of the marketplace, proprietary position, regulatory exclusivity, anticipated or approved labeling, present and future market potential, andprofitability ( including pricing and reimbursement status achieved or likely to be achieved )