definiens: means any Know - How that is Controlled by HMI or a ny of its Affiliates as of the Effective Date or during the Term ( other than Joint Know - How ) that is necessary or useful to Research, Develop, Manufacture, or Commercialize any Candidat e or Product, but in each case, excluding Know - How directed to [ * * * ] . For clarity, HMI Know - How includes HMI Mater ials, HMI Program Know- How, HMI Platform Know - How, HMI Product Know - How, HMI Ma nufacturing Know - How, and HMI Assigned Know - How ( in each case excluding Know - How directed to [ * * * ] . For clarity, HMI Know - How includes Know - How Controlled by HMI or any of i ts Affiliates regarding the [ * * * ] of the Candidates