definiens: means costs for CEPHEID research, development, and engineering ( RD&E ) support, corresponding to fully burdened RD&E costs which shall be comprised of direct RD&E costs, RD&E overhead, and direct costs and allocated overhead associated with constructing and delivering any prototype Modules or Consumables required by ETG . Fully Burdened RD&E Costs will be estimated in terms of average cost per Full Time Equivalent ( FTE ) and will be established in accordance with the Budget 1.20 . means [ an integrated system for detection of DNA or RNA sequences that : a ) employs PCR or other thermally controlled nucleic acid amplification methods ; b ) contains between one and eight reaction sites ; c ) carries out the processes of amplification, detection, analysis, reporting, and user interface all in one case or housing ; d ) is capable of operating on battery power ; and e ) mayor may not employ fluidic sample preparation cartridges that are designed for integrated use with the system . ] 1.21 . [ means the United Kingdom Government 's Integrated Biological Detection System program, which specifies the development of an Integrated Military Bioagent Detection System . ] 1.22 . means a CEPHEID proprietary nucleic acid amplification Module comprised of ( 1 ) a single site, discrete, individually controllable heater sleeve containing a heater element and designed to accept a disposable reaction tube or cartridge, ( 2 ) an integrated cooling mechanism, such as a fan, that enables passage of ambient or cooled air across the heater sleeve, and ( 3 ) optical blocks containing solid state components that enable optical interrogation Page 6 of6 CONFIDENTIAL TREATMENT REQUESTED of the reaction solution in the reaction tube or cartridge, as it may be modified and improved from time to time