definiens: means a license under the Isis Core Technology Pate nts or the Isis Manufacturing Patents ( but not under the Product - Specific Technol ogy Patents ) ( i ) granted by Isis to a Third Party t o use ASOs solely to conduct such Third Party ’s own internal R esearch, or ( ii ) granted by Isis to a Third Party ( provided that such Third Party is [ * * * ] and neither such Third Pa rty nor any of its Affiliates is [ * * * ] to manufactu re ASOs solely for unaffiliated third parties ; provided, however, in each case, any such ASOs are not specified in such license or a related document to be ASOs ( a ) that a ct predominantly by [ * * * ] Clusterin [ * * * ] or ( b ) th at are [ * * * ] Clusterin [ * * * ] or products containing such ASOs . F or purposes of clarification, a Permitted License s hall not permit Isis or its Affiliates to supply to a Third Party ASOs that act predominantly by [ * * * ] Clusteri n [ * * * ] or that are [ * * * ] Clusterin [ * * * ] or products containi ng such ASOs