definiens: means all Know - How Controlled by [COMPANY] or its Affiliates on the Effective Dateor at any time during the Agreement Term necessary to Develop or Commercialize a Product or disclosed by [COMPANY] toAkcea and specifically relating to ( a ) the composition of matter of a Product or ( b ) methods of using a Product as aprophylactic or therapeutic ; provided, however, Know - How Controlled by [COMPANY] or any of its Affiliates that ( i ) consists ofsubject matter applicable to oligonucleotide compounds or products in general or ( ii ) relates to an oligonucleotidecompound that does not specifically modulate expression of TTR via the binding, partially or wholly, of such compound toRNA that encodes TTR, will not be considered [COMPANY] Product - Specific Know - How, and in the case of ( i ) and ( ii ), suchKnow - How will be considered [COMPANY] Core Technology Know - How