definiens: means all Joint Patents claiming : ( a ) the composition of matter of aLead Compound or Product ; ( b ) methods of using a Lead Compound or Product ; or ( c ) the manufacture ofa Lead Compound, but excluding in each case : ( 1 ) Patents that include claims that are directed to subjectmatter and have a scope that is applicable to microRNA Compounds in general and do not exemplify orclaim Lead Compounds or Products and ( 2 ) Patents that do not exemplify or claim Lead Compounds orProducts and that include claims directed to the identification or isolation of microRNAs that are notCollaboration Targets, or to the production, composition, or use of microRNA Compounds that are notLead Compounds or Products ( which Patents Controlled by Regulus or its Affiliates described in ( 1 ) and(2 ) will, for clarity, be considered to be Regulus Core Technology Patents )