definiens: shall mean ( gross amounts billed or invoiced by VOX, its Affiliates or VOX Partners, as the case may be, to non - Affiliate Third Parties ( ) for the sale of any Product, less the followign deductions, in each case to the extent specifica lly related tot eh Product and taken by such Buyers or otherwise paid or accrued for by VOX (, ' Permitted Deductions " ): ( i ) trade, cash, promotional and quantity discounts ; ( ii ) taxes on sales ( such as excise, sales or use taxes or value added tax ) to the extent imposed upon and paid directly with respect to the sales price ( and excluding national, state or local taxes based on income ) ; ( iii ) freight, insurance, packing costs and other transportation charges to the extent included in t4he invoice price to the Buyer ; ( iv ) amounts repaid or credits taken by reason of damaged goods, rejections, defects, expired dating, recalls, returns or because of retroactive price reductions ; ( v ) charge back payments and rebates granted to ( a ) managed health care organizations, ( b ) federal, provincial and lor local governme nts or their agencies, ( c ) purchasers and reimbursers, or ( d ) trade customers, including without limitation, wholesalers and chain and pharmacy buying groups ; and ( vi ) documented customs duties actually paid ) shall not include any consideration received with respect to a sale, use or other disposition of any Product as part of a clinical trial prior to the receipt of applicable Regulatory Approval for the Product