definiens: shall mean the marketing authorization for marketing and sale of theProduct in the Territory as a result of submitting marketing authorization application to the relevantRegulatory Authorities using the Registration Dossier ; 2 1.4.9 shall mean the ratio, expressed as a percentage, calculated on a per FinishedPack of Product, of : ( Net Selling Price – Supply Price ) x 100 % Net Selling Price 1.4.10 means the gross amount invoiced by [COMPANY] and its Affiliates for sales of Product duringa period of time in the Territory reduced by the following to the extent that they are referred to inthe relevant sales invoices:(i ) trade, quantity, cash and promotional discounts actually allowed and taken, costs of valueadded programs in the normal course of business;(ii ) credits or allowances granted on account of rejections, returns, defects, recalls orretroactive price reduction;(iii ) freight, insurance and other transportation and/or logistics charges incurred in deliveringand / or distributing the Product to and from third parties and/or Galena;(iv ) excise, value added, sales, user and taxes imposed upon and paid with respect to suchsales ( excluding taxes based on income);(v ) rebates or discounts pursuant to agreements or applicable law . ; 1.4.11 means [COMPANY] ’s and its Affiliates ’ weighted - average net selling price per Productof a particular size calculated by dividing [COMPANY] ’s and its Affiliates ’ Net Sales of the Products of thatsize by the number of Products of that size sold by [COMPANY] and its Affiliates