definiens: means, with respect to the efforts to be expended by a Party with respect to any objective, those reasonable, good faith efforts to accomplish such objective as such Party would normally use to accomplish a similar objective undersimilar circumstances, in particular taking into account the then - current urgency of the COVID-19 crisis . With respect to any efforts relating tothe Development, Regulatory Approval or Commercialization of a Candidate or Product by a Party, generally or with respect to any particularcountry in the Territory, a Party will be deemed to have exercised Commercially Reasonable Efforts if such Party has exercised those effortsnormally used by such Party having regard to the circumstances, in the relevant country, with respect to a compound or protein, product 4or product candidate, as applicable ( a ) of similar modality Controlled by such Party, ( b ) to which such Party has similar rights, ( c ) which is ofsimilar market potential in such country, and ( d ) which is at a similar stage in its development or product life cycle, as any Candidate orProduct, in each case, taking into account all Relevant Factors in effect at the time such efforts are to be expended . Further, to the extent thatthe performance of a Party ’s obligations hereunder is adversely affected by the other Party ’s failure to perform its obligations hereunder, theimpact of such performance failure will be taken into account in determining whether such Party has used its Commercially ReasonableEfforts to perform any such affected obligations