definiens: means a composition comprising a Vaccine Antigen, which composition is developed and administered for the purpose of induc ing an immune response specific to such Vaccine Ant igen, solely for the prevention or treatment of the disea se against which such Vaccine Antigen is directed, whereby such prevention or treatment occurs through the imm une response induced by such Vaccine Antigen ( exclu ding for clarity any form of passive immunization or use of additional molecules, including without limitat ion checkpoint inhibitors, to modify or otherwise affec t the immune response induced by such Vaccine Antig en provided, however, that a Vaccine Composition may i nclude one or more adjuvants solely for use in conj unction with such Vaccine Antigen to enhance the immune res ponse induced by such Vaccine Antigen, and, for cla rity, excluding any use with any form of passive immuniza tion or with any checkpoint inhibitors or other add itional non - adjuvant molecules ), which Vaccine Composition or any portion thereof ( e.g., a polysaccharide, carbohydrate, peptide or other moiety contained in such Vaccine Composition ) is discovered or produced based on the use of any Extract(s ) as the starting materi al, whether produced by Sutro, or produced by Sutro Vax or a CMO established or approved by Sutro using any Extr act(s ) supplied by Sutro or under a license from Su tro, in each case in any production system, whether cell - fr ee or cell - based . Notwithstanding the foregoing, shall exclude any type of cancer vacci ne ( other than prophylactic vaccines where the agen t causing cancer is an infectious pathogen ( e.g. HPV vaccine ), but excluding for clarity any therapeutic cancer vaccine or companion diagnostic for cancer vaccine applications ) . For clarity, [COMPANY] ’s Pneumococcal Conjugate Vaccine is a Vaccine Composition, as defi ned herein