definiens: means, as to a Party and a Product, efforts consistent with the efforts andresources normally used by a pharmaceutical or biotechnology company, as applicable, of comparable size and resources ofsuch Party, in the exercise of its reasonable business discretion relating to the Research, Development or Commercializationof a similar product with similar product characteristics, that is of similar market potential at a similar stage in itsDevelopment or product life, taking into account issues of patent coverage, safety and efficacy, product profile, thecompetitiveness of the marketplace, the proprietary position of the compound or product, the regulatory structure involved, and other technical, legal, scientific and/or medical factors, and, solely with respect to BSP ’s Development and / orCommercialization ( but not Research ) of Collaboration Compounds under this Agreement, the profitability of suchCollaboration Compounds ( including without limitation pricing and reimbursement status achieved ) as compared to otherproducts within BSP ’s portfolio