definiens: shall mean ex vivo Gene therapy for human disorders limited to adrenoleukodystophy ( ALD)(including but not limited to AMN, CCALD, and all other variants of this disease caused by geneticmutations ), beta hemoglobinopathies ( including but not limited to beta - thalassemia and sickle cell anemia ), [ * * * ] leukemias, lymphomas, B - cell malignancies and solid tumors by producing chimeric antigen receptor T - cells [ * * * ] for [ * * * ] and [ * * * ] the includes in vivo as well as ex vivo Gene therapy . [ * * * ] 2.2 . The following sentence is hereby added to the end of Article 2.1 of the Agreement : 2.3 . The following sentence is hereby added to the end of Article 4.4 of the Agreement : “ Further, Licensee shall have the rightto seek patent term extension according to the Drug Price Competition and Patent Term Restoration Act of 1984 ( Hatch - Waxman ) for any Patent based on Product(s ) ( in addition to an SPC(s ) as provided in Article 4.4 ) . Institut Pasteur willreasonably assist Licensee if Licensee elects to initiate to obtain any such patent term extension ”