definiens: means any and allValid Claims Directed to HCV of United States and foreign patents and patentapplications : ( a ) which are based on inventions conceived or rights acquired _ ~ ; ( a ) are not ROCHE Optioned Patents ( as defined below ) ; \5rwhich claim HCV nucleic acid sequence(s ) or a method to use ( other than in themanufacture of peptides ) or detect such sequences specifically ; ( c ) which areowned by, licensed to or otherwise controlled by ROCHE or its Affiliate, withrights to license or sublicense ; and ( d ) with respect to which ROCHE has theright to grant the option provided for in Section 2.7 of this Agreement . Forpurposes of this Agreement, an invention will be deemed to have been conceivedif there is a patent, patent application, written invention disclosure statement orother tangible document ( whether or not witnessed ) describing such invention