definiens: means ( a ) the Lead Candidate and Related Collaboration RNP Complex(es ) ( as defined in the Master Collaboration Agreement ) identified as in the Licensed Program Addendum for the Initial Licen sed Program attached hereto as Exhibit A -1 ; ( b ) any Lead Candidate and Related Collaboration RNP Complex(es ) ( as defined in the Master Collaboration Agreement ) identified as in a Licensed Program Addendum ; ( c ) any other Collaborati on RNP Complex from 15 the Research Program under the Master Collaboration Agreement that ( i ) incorporates or contains the same RGEN as any Lead Candidate under clause ( a ) or ( b ) above and ( ii ) is Directed to the same Licensed Program Target as such Lead Candidate ( the RNP Complexes in clauses ( a ), ( b ) or ( c ), the ) ; and ( d ) any other RNP Complex that ( i ) is Directed to a Licensed Program Target, ( ii ) is a variant or improvement of an Editas -Provided RNP Complex made by or o n behalf of Juno or any of its Affiliates during the Term in the course of its activities performed under this Agreement and has Documented Lineage to such Editas -Provided RNP Complex, and ( iii ) is covered by any Editas Licensed Background Patent or Editas Licensed Collaboration Patent, or is otherwise made by or on behalf of Juno or any of its Affiliates during the Term in the course of its activities performed under this Agreement directly through the use of the Editas Licensed Background Know -How or Edit as Licensed Collaboration Know -How ( as such use is documented in Juno ’s or its Affiliate ’s written records )