definiens: and ctors involved in providing the Services under this Agreement ; 1.9 means the services to provided by sse plll'Suarrt to this Agreement ( as amended from lime to time in accordance with the provisions of this ; \greemenl ) ami olher as may from time to time be agreed upon 1;\1 RGI < lncl SSC, including Testing Services, consultation ami tissue storage, in connection with Ihis Agreement and as further detailed ' iilnd agreed upon In a Protocol pursuant to Article 1 oolow : 1,10 means thalthis Agreement shall commence on Ihe Effective Dale and shall continue IInlll Ihe fifth ( 5'Initial Term " ), unless sooner lerminall'ld in ! in authorized manner, This agreement wililhereafter automatically renew for successive three year terms unle " " either party giv!is nolice of its intent ! ' : .ot 10 renew 90 days In advance of such renewal date, Termination wilillot end wor'T&sting Services " means, among other things, c : onclu(,1ing mo!ecular·based tumor tissue profiling using a proprietary and patented process developed by RGI which involves 11 complex molecular analysis of speclfic molecular markers that provides valuable tumor specific gene expression information obtained from a paraffin preserved fresh or frozen tissue sample aad molecular-4 CONFJDENTIAL TREATMENT REQUESTEB based tumor tissue profiling using EGF - receptor immunohistochemistry ( ), HER-2 IHC, estrogen receptor IHC