definiens: means : · U.S. Pat . No . 5,232,917 ; 7 · U.S. Pat . No . 5,591,733 “ Methods, Compositions and Compounds for Allosteric Modulation of the GABAReceptor by Members of the Androstane and Pregnane Series ” ; · U.S. Pat . No . 5,208,227 ; · U.S. Pat . No . 5,319,115 ; foreign counterparts thereto, any U.S. or foreign continuation - in - part, continuation or divisional applications thereof, any patent granted on any aforesaid patent application, and any extension, re - examination, or reissue of any of suchpatent, and any U.S. or foreign continuations, continuations - in - part, divisionals, reissues re - examinations orextensions of any of the foregoing