definiens: shall mean, with respect to the efforts to be expended by a Party withrespect to any objective, reasonable, diligent, good faith efforts to accomplish such objective as such Partywould normally use to accomplish a similar objective under similar circumstances, it being understood andagreed that with respect to the research, discovery, development or commercialization of any Product ( orCompound, as applicable ) by either Party, such efforts shall be substantially equivalent to those efforts andresources commonly used by such Party for a product owned by it or to which it has rights, which productis at a similar stage in its development or product life and is of similar market potential taking into accountefficacy, safety, approved labeling, the competitiveness of alternative products in the marketplace, thepatent and other proprietary position of the product, the likelihood of regulatory approval, the profitability andcommercial potential of the product to the applicable Party ( including the amounts payable to licensors ofpatent or other intellectual property rights ), alternative products and other relevant factors . CommerciallyReasonable Efforts shall be determined on a market - by - market and Product - by - Product basis, and it isanticipated that the level of effort will be different for different markets, and will change over time, reflectingchanges in the status of the Product ( or Compound, as applicable ) and the market(s ) involved