definiens: means collectively and i ndividually the Akt, Chkl and Plk Targets . Akt Targ et means the Akt protein and the biological processes of phosphorylation mediated by Akt, including but n ot limited to the phosphorylation of BAD, GSK3, PFK2, GLUT4, caspase 9 and telomerase . Chkl Target means the Chkl protein and the biological processes of phosph orylation mediated by Chkl, including but not limit ed to the phosphorylation of Cdc25C. Plk Target means the Plk protein and the biological processes of phosphoryl ation mediated by Plk . Akt, Chkl and Plk Targets shall in clude the human Akt, Chkl and Plk Target and any su btypes and isoforms thereof, as well as any homologs there of from any other species