definiens: of a Party means that level of efforts, expertise and resources commonly applied by such Party to carry out a particular task or obligation, consistent with the general practice followed by such Party relating to other pharmaceutical c ompounds, products or therapies owned by it, or to which it has exclusive rights, which are of similar market potential at a similar stage in their development or product life, taking into account issues of safety and efficacy, product profile, the competi tiveness of other products in development and in the marketplace, supply chain management considerations, the proprietary position of the compound, product or therapy ( including with respect to patent or regulatory exclusivity ), the regulatory structure in volved, the profitability of the applicable compound, product or therapy ( including pricing and reimbursement status achieved ), and other relevant technical, legal, scientific or medical factors . For clarity, the of a Part y under this Agreement will be determined on an indication -by - indication and country -by - country basis within the Territory, and it is anticipated that the level of effort for different indications and countries may differ and may change over time, reflecti ng changes in the status of the compound, product or therapy and the indications and country(ies ) involved