definiens: shall mean all tra de secrets, know- how, and other confidential and proprietary information owne d by BRNI or licensed to NRV II by BRNI on or subsequent to the Effective Date, to the extent cov ering any of the following : 6 ( i ) an in vitro therapeutic test system that uses cult ured human fibroblasts or any other method to detect and measure PKC or other assays with periphe ral cells to predict the presence of Alzheimer ’s Disease in humans, and all succeeding t est formats ( including test kits ) ; ( ii ) the PKC activators ( including bryostatin, analogs, PUFAs, and other PKC activator s ) and their therapeutic applications in humans or animals ; ( iii ) the LDL or ApoE- based drug delivery system that is targeted to enha nce access of all manner of drugs and therapeutics to the brain by facilitation of transport of such drugs across the Blood - Brain -Barrier in humans or animals ; and ( iv ) the carbonic anhydrase activators and their therape utic applications in humans or animals