definiens: means ( a ) [ * * * ], and ( b ) [ * * * ] that, as of the AmendmentEffective Date or, subject to Section 3.7, at any time during the Term, ( i ) ( x ) MTI or its Affiliates own, and ( y ) withrespect to which MTI or its Affiliates Control Patent Rights Covering such cytotoxic compound or Control Know - Howthat relates to or consists of such cytotoxic compound, and ( ii ) that the Parties have mutually agreed to include as aCytotoxic Compound by expressly identifying it as such in the applicable Research Plan, and any Improvements toany of the foregoing ( ( a ) and ( b ) ) . All Cytotoxic Compounds that are identified in a Research Program as of theAmendment Effective Date are set forth on Schedule E.1, subject to updating in accordance with Section 2.2.2