definiens: means, with respect to the efforts to be expended by a Party with respectto any objective, reasonable, diligent, good faith efforts to accomplish such objective as such Party would normallyuse to accomplish a similar objective under similar circumstances for such Party ’s benefit exclusive of the otherParty . With respect to any objective relating to the Development, Manufacture or Commercialization of a LicensedProduct by a Party, means efforts and resources normally used by such Partywith respect to a product owned by such Party, or to which such Party has similar rights, that is of similar market andtherapeutic potential at a similar stage in the Development or life of such product, taking into account issues ofsafety, efficacy, costs of development, product profile, the competitiveness of the marketplace, the proprietaryposition of the product including the nature and extent of its market exclusivity ( including Patent coverage andregulatory exclusivity ), the regulatory structure involved and the likelihood of approval, profitability of the product, andother relevant commercial factors . For the purposes of Section 4.4, Commercially Reasonable Efforts shall bedetermined [ * * * ] [ * * * ] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission . Confidentialtreatment has been requested with respect to the omitted portions