definiens: shall mean, with respect to the efforts to be expended by a Party with respect to any objective orobligation under this Agreement, such commercially reasonable, diligent and good faith efforts as such Party wouldnormally use to accomplish a similar objective or perform a similar obligation under similar circumstances, actingreasonably promptly and in a sustained manner, and taking into account scientific, medical and commercially relevantfactors such as ( as applicable ) stage of development, product life, patent position, strategic value, [ ... * * * ... ] marketpotential, medical, safety and regulatory issues, in accordance with the following:1.45.1 For Regulus : Regulus shall apply its commercially reasonable Diligent Efforts in the conduct of all activitiesand obligations for which Regulus is responsible under this Agreement, in accordance with ( a ) the Initial ResearchPlan, ( b ) each Research Plan for each 7***Confidential Treatment RequestedResearch Program, and ( c ) if [COMPANY] has not exercised its [ ... * * * ... ] with respect to a Program, the Early Development Plan for therelevant Early Development Program, in each case as established hereunder . Such efforts will be consistent at all times with theefforts and resources normally used by Regulus or, where one of its Parent Companies has already conducted or is activelyconducting activities similar to those described in the Initial Research Plan, the relevant Research Plan or the relevant EarlyDevelopment Plan, as applicable, but Regulus has not previously conducted such activities, the efforts and resources normallyused by Regulus ’ Parent Company, in the exercise of Regulus ’ or its Parent Company ’s ( as applicable ) reasonable businessdiscretion relating to the research and development progression of a compound in its own pipeline at a [ ... * * * ... ] as comparedto the Collaboration Compound or Licensed Product in question