definiens: means, with respect to particular obligationsor tasks, such level of efforts applied to carry out such obligations or tasksconsistent with the efforts used in the biopharmaceutical industry by a company ofcomparable size in connection with the development or commercialization ofbiopharmaceutical products that are of similar status, to accomplish suchobligations or tasks, at the same stage of development or commercialization, asapplicable, for internally developed healthcare products in a similar area withsimilar market potential, at a similar stage of their product life taking into accountthe existence of other competitive products in the market place or underdevelopment, the proprietary position of the product, the regulatory structureinvolved, the anticipated profitability of the product and other commercially - relevant factors . It is understood that such factors may change from time to timebased upon changing scientific, business and marketing and return oninvestment considerations and that the level efforts typically devoted by Licenseemay also change, based on such changes and/or changes in development orcommercial stage