definiens: means the Investigator Sponsored Trial Agreement between [COMPANY] and theMayo Clinic dated October 5, 2012, as amended April 4, 2013, June 13, 2013, August 14, 2013, October 17, 2013 andMay 2, 2014 ( as may be further amended from time to time ), which has been superseded by the Clinical TrialAgreement by and between [COMPANY] and Mayo Clinic, dated July 31, 2014, as amended September 2, 2014 andSeptember 16, 2014 ( as may be further amended from time to time ) under which a clinical study of GRN163L entitled“A Pilot Open - Label Study of the Efficacy and Safety of Imetelstat ( GRN163L ) in Myelofibrosis and other MyeloidMalignancies, ” has been and is being, as of the Execution Date, performed by the Mayo Clinic under the direction ofDr . Tefferi ( IND No . 116129 )