definiens: means Patent Rights Controlled by a Party or any of its Affiliates on or after the Effective Date, including any Program Patents, claiming ( i ) the specific composition of matter of a Collaboration Product, or ( ii ) methods ofusing a Product as a prophylactic or therapeutic ; provided however, Patent Rights Controlled by Isis or any of its Affiliatesthat ( y ) include claims that are directed to subject matter applicable to ASOs or products in general, or ( z ) include an ASO, thesequence of which targets the RNA that encodes a Collaboration Target and the RNA of a gene that does not encode aCollaboration Target ( or similarly, a non - ASO molecule that binds, mimics or otherwise affects a protein or RNA that isencoded by a [COMPANY] Idec Alternate Modality Target and the RNA of a gene that does not encode a [COMPANY] Idec AlternateModality Target ), will not be considered Product - Specific Patents, and in the case of ( y ) and ( z ), such Patent Rights will beconsidered Isis Core Technology Patents