definiens: shall mean [ the gross sale . price oftb . Product invoiced by NUPATHE, its sublicensee or their respective AffIliates to customers who are not Affiliates ( or who are Affiliate . but are the end user . of the Product ) I •••• to the extent actuaHy paid or accrued by NUPATHE . it . sublicensee or their respedive Afrili.te . ( as appUcable ) . ( aJ credits, allowances, discounts and rebates to, and cbargebacks from the account of, such customers for spoiled, damaged, out - dated and returned Produd ; ( b ) freight and insurance cost . incurred by NUPATHE . its sublicensee or their respective Affiliates ( as appUcable ) in transporting the Produd in final form to such customers ; ( e ) casb . quantity and trod