definiens: shall mean any product comprising a Biologic and/or Compound that isdirected to or against, or incorporates or is derived directly from, a Committed Lead Target forwhich [COMPANY] has exercised its Selection Option as provided in Section 3.4.4, ( a ) which isCovered by one or more Valid Claims included within the FivePrime Ba ckground PatentRights, FivePrime Collaboration Patent Rights or Joint Patent Rights ; or ( b ) which wasdirectly based upon, or directly incorporated or incorporates FivePrime B ackground Know - How, FivePrime Collaboration Know - How or Joint Know - How . Licensed Product shall alsoinclude any Combination Product . For the aggregation of Net Sales for the purpose ofdetermining the applicable royalty rate under Section 6.4, all Combination P roducts and singleagent Licensed Products comprising the same Biologic or Compound ( as the c ase may be)shall be considered the same Licensed Product, regardless of the form ulation, dosage strength, route of administration, packaging or product indication thereof or any other ac tiveingredient(s ) contained therein