definiens: means Patent Rights Controlled by a Party or any of its Affiliates on or after the EffectiveDate, including any Program Patents, claiming ( i ) the specific composition of matter of a Collaboration Product, or ( ii)methods of using a Product as a prophylactic or therapeutic ; provided however, Patent Rights Controlled by [COMPANY] orany of its Affiliates that ( y ) include claims that are directed to subject matter applicable to ASOs or products ingeneral, or ( z ) include an ASO, the sequence of which targets the RNA that encodes a Collaboration Target and theRNA of a gene that does not encode a Collaboration Target ( or similarly, a non - ASO molecule that binds, mimics orotherwise affects a protein or RNA that is encoded by a [COMPANY] Alternate Modality Target and the RNA of a gene thatdoes not encode a [COMPANY] Alternate Modality Target ), will not be considered Product - Specific Patents, and in the caseof ( y ) and ( z ), such Patent Rights will be considered [COMPANY] Core Technology Patents