definiens: means, other than the prescription pharmaceutical product containing the Compound and known as Macugen ® as of the Restatement Date and any new doses and dosing regimens thereof approved after the Restatement Date, provided that such new doses or dosing regimens do not alter the Product itself or any ingredient contained in such Product as of the Restatement Date, any product that ( a ) contains or is based on the Compound, or any metabolites or prodrugs of such aptamer or any hydrates, conjugates, salts, esters, isomers, polymorphs or analogues of any of the foregoing, either alone or in combination with one or more other therapeutically active substances, and ( b ) is for use in the Field ; including for the avoidance of doubt any un - pegylated formulation of the prescription pharmaceutical product containing the Compound and known as Macugen ® as of the Restatement Date