definiens: and by MetaMorphix and JHU as as such terms are mo re fully defined in that Agreement ) ; WHEREAS, as of January 26, 1999, the Parties a nd JHU entered into that certain Amended and Restat ed Collaboration Agreement ( as subsequently amended by the Sponsored Research Amendments ( as defined below ), the ) relating to the disco very, characterization, and development of factors in the TGF - b Superfamily ( referred to by GI as and by MetaMorphix and JHU as as such terms are more fully defined in that Agreement ), which agreem ent supercedes and replaces the 1994 Agreement ; WHEREAS, effective as of January 1, 2001, the Parties and JHU executed and delivered that certain First Amendment to 1999 Amended and Restated Collaboratio n Agreement and, effective as of June 30, 2002, the Parties and JHU executed and delivered that certain Second Amendment to 1999 Amended and Restated Collaboration Agreement ( collectively, the ) each relating to Additiona l Sponsored Research at JHU focused solely upon MetaM orphix Factor GDF-8 ; and WHEREAS, the Parties desire to disclose and sh are freely with each other Confidential Information regarding MetaMorphix Factor GDF-8 and to expand the present cross licenses ( granted under the 1999 Agreement ) between the Parties in respect, only, to MetaMorphi x Factor GDF-8 and all internal and external resear ch related to such Factor, including, but not limited to, the June 1, 1998 — December 31, 2000 Sponsored Research at JHU in accordance with Section 3.3 of the 1999 Agreemen t and the post January 1, 2001 Additional Sponsored Research in accordance with the Sponsored Research Amendments