definiens: as defined in Article 1.27 means any member of the class of ~ ubstituted 4-'f - H chromene~ analogs and derivatives set, forth below : : : :) .-A compound of F onnula 1 : A R5 · ' ® Qcy .. X Z ( 1 ) or a phannaceutically acceptable salt or prodrug thereof, wherein : X is O, S or NR6 wherein R6 is hydrogen or an optionally substituted alkyl ; Y is CN, COR7, COZR7 or CONRxR y, wherein R7, Rx and Ry are independently hydrogen, CI - IO alkyl, halo alkyl, aryl, fused'aryl, carbocyclic, a heterocyclic group, a heteroaryl group, alkenyl, alkynyl, aryl alkyl, arylalkenyl, arylaJ1.)'Ilyl, heteroaryla1kyl, heteroarylalkenyl, heteroarylalkynyl, carbocydoaikyl, heterocycloalkyl, hydroxyalkyl, or aminoalkyl ; or Rx and Ry are taken together with the nitrogen to fonn a heterocycle ; Z is NRsR9, NHCORs, N(CORs)z, N(CORs)(COR9 ), N = CHORs, or N = CHRs, wherein Rs and R9 are independently H, Cl-4alkyl or aryl, or Rs and R9 are combined together with the group attached to them to fonn a heterocycle ;, Rs is hydrogen or CI - IO alkyl ; A is optionally substituted and is aryl, heteroaryl, saturated carbocyclic, partially satrirated carbocyclic, saturated heterocyclic, partially saturated heterocyclic, arylalkyl or heteroarylalkyl ; and