definiens: means that certain Collaboration and License Agreement between the Parties, dated as of June 27, 2006, pursuant to which [COMPANY] has granted Collaborator certain rights and licenses with respect to the development and commercialization of Hematide and the Product worldwide outside Japan . 3 . Amendment to Section 2.4(c)(iii ) . The Parties hereby agree to amend and restate Section 2.4(c)(iii ) of the Japan Agreement by replacing such Section, in its entirety, with the following : ( iii ) altering the n)ev : ei.gpm ~ pt}>~,M ] or otherwise proposing to conduct or conducting any Development activities in a manner that would reasonably be expected to[E,\dy¢rse ~ yjmpacrthet dev ~ loprn ~ n~ or commercialization efforts for ~roduc ~ sJp ~ sll ~ t;to;~.:.the ; _, Glbl?~f!;'48f~~Ill ~ ni, ] other than for purposes of [ ~g.c4'es.~mg, pa,1;iel!t',safety;.co ~ cems ] or pursuant to a requirement imposed by the Regulatory Authorities in the Licensed Territory or the external monitoring board for such trial