definiens: means, with respect to a Party, carrying out of tasks andobligations under this Agreement with respect to the Development, Manufacture or Commercialization of a Product orGE Product, as applicable, at the level of efforts as would be consistent with actions in respect to a productControlled by such Party that is of a market potential similar to the market potential of such Product or GE Product, as applicable, and at a similar stage in the Development or of its product life, taking into account data from Product - or GE - Product - related ( as applicable ) clinical trials ( whether or not such Party is the sponsor of such trial);establishment or projected position of such Product or GE Product, as applicable, in the marketplace ; thecompetitiveness of the marketplace ; the proprietary position of the Product or GE Product, as applicable ; anyblocking Third Party intellectual property positions, as applicable ; the regulatory environment with respect to productssimilar to the Product or GE Product, as applicable ; the likelihood of Regulatory Approval ; the actual or projectedpricing and reimbursement of such Product or GE Product ; the relative safety, efficacy, convenience and productlabel of the Product or GE Product ( as applicable ) as compared to other products ; the actual or projected profitabilityof such Product or GE Product, including the cost of Manufacture, royalties and milestones payable to Licensors ofPatent or other Intellectual Property rights ; and all other relevant scientific, technical and commercial factors