definiens: means any [COMPANY] Test Material : ( A ) which, in the cQurse of screening such [COMPANY] Test Material by or for [COMPANY] and its Affiliates using an Exclusive Screen or Nonexclusive Screen hereunder, demonstrates sufficient Activity with respect to the target in any such Screen so as to be considered thereafter by [COMPANY] for approval and development as a Lead Compound, and ( B ) where the active substance therein ( or, if such active substance is an Analog of another original active substance, then such Analog or such original active substance ) is not identified by, or was not known to, [COMPANY] or anyofiiS - Alliliates or research collaborators as possessing significant Activity with respect to the receptor or other target to which the active substance is targeted prior to the date that such active substance was first identified as having ignificant Activity with respect to such receptor or other target by reason of the use of such Exclusive or Nonexclusive Screens by or for [COMPANY] and its Affiliates