definiens: means ( i ) the diseases or medical conditions includ ed in the three families of diseases or medical conditions se t forth on Schedule 1.74, to the extent the various diseases or medical conditions are expressl y identified on that schedule ; and ( ii ) any other Indication for a disease or medical condition with a prevalence of ten ( 10 ) cases or less per one hundred thousand ( 100,000 ) persons as publi shed by either one ( or both ) of Orphanet or the National Institutes of Health National Libra ry of Medicine . For purposes of this Section 1.74, any group of Indications for which a single Regulatory Approval may be obtained shall be considered a single Indication, a nd if each Indication in such group of Indications meets the criteria described in clause ( ii ) above, such group of Indications shall together be considered a single Ultra Orphan Indica tion, unless the total prevalence of all diseases in the group exceeds 30 in 100,000 . If the patient numbers in a relevant publication are given in a range, then for the purpose of deter mining the prevalence of the disease, the geometric mean of such range will be used ( i.e., the following formula will be used : where P is the total prevelance for the purpose of this def inition, L is the low end ( minimum ) of the relevant prevelance range, and H is the high end ( maximum ) of the relevant prevelance range )