definiens: means with respect to activities of a Party in the discovery, Development or theCommercialization of a particular Product, the efforts and resources typically used by that Party in the development ofproduct candidates or the commercialization of products of comparable market potential taking into account all relevantfactors including, as applicable and without limitations, stage of development, mechanism of action, efficacy and safetyrelative to competitive products in the marketplace, actual or anticipated labeling, the nature and extent of marketexclusivity ( including patent coverage and regulatory exclusivity ), cost, actual or projected profitability ( provided [ … * * * … ] ) and likelihood of obtaining marketing approval . Commercially Reasonable Efforts will be determined on amarket - by - market and indication - by - indication basis, and it is anticipated that the level of effort will be different fordifferent markets and will change over time reflecting changes in the status of the Product and the markets involved