definiens: means the period commencing upon the EFFECTIVE DATE and ending on March 31, 2014 . ” 3 . Amendment to Section 3.5 ( Forecasts, Purchase Orders and Minimum Orders ) . Section 3.5 is hereby amended to change the minimum annual purchase requirement from a minimum of [ * * * ] to [ * * * ] . As amended, Section 3.5 shall read in its entirety : “ 3.5 FORECASTS, Purchase Orders and Minimum Quantities . Within [ * * * ] ) days after the comme ncement of any CONTRACT YEAR, CYDEX shall provide HOVIONE with a written [ * * * ] forecast of its anticipated purchase order for commercial quantities of CAPTISOL for the subsequent [ * * * ] ( ), specifying quantities and delivery dates . Not later than [ * * * ] months in advance of such CONTRACT YEAR, CYDEX shall be required to place its irrevocable purchase order for [ * * * ] % of the aggregate quantities of CAPTISOL specified in its FORECAST, provided that CYDEX shall have the right, with respect to not more than [ * * * ] % of FORECASTED quantities, to ( i ) [ * * * ] such FORECASTED quantities, and/or ( ii ) [ * * * ] among deliveries scheduled and new delivery dates, provided in aggregate the changed amounts are not disproportionately concentrated in time thereby causing HOVIONE to produce and deliver in that period in excess of the [ * * * ] % its obligations . CYDEX ’s irrevocable purchase order shall be for at least [ * * * ] . HOVIONE shall confirm acceptance of such annual irrevocable purchase order within [ * * * ] days of receipt . Should CYDEX desire to make additional changes in quantities and/or delivery dates, CYDEX shall notify HOVIONE and HOVIONE will use its best commercial efforts to accommodate CYDEX ’s requests . ” 4 . Deletion of Section 3.7 ( Additional Inventory ) . The partie s agree that HOVIONE is not required to manufacture and hold in inventory an additional quantity of CAPTISOL equal to [ * * * ] % of the quantities specified by CYDEX in each of its purchase orders . Accordingly, Section 3.7 of the AGREEMENT is hereby deleted in its entirety