definiens: means, except as provided below, all development activities that relate to expanding Regulatory Approval ofSymproic with respect to new or improved indications, presentations, formulations, dosage forms, dosage strengths, and/or line extensionsincluding, without limitation : ( a ) research, nonclinical studies, toxicology, and Clinical Trials ; and ( b ) preparation, submission, review, anddevelopment of data or information for the purpose of submission to a Regulatory Authority to obtain, maintain and/or expand RegulatoryApproval of Symproic with respect to such new or improved indications, presentations, formulations, dosage forms, dosage strengths, and / orline extensions ; provided, however, that Development shall exclude Commercialization of Symproic . For clarity, Development shall notinclude Phase 4 Trial commitments that are required by a Regulatory Authority as a condition of Regulatory Approval of Symproic in theField in the Territory . has a correlative meaning