definiens: . Commercially Rea sonable Efforts means the efforts normally used by a United States biotechnol ogy or pharmaceutical company with resources simila r to those of PRESIDIO to Develop or Commercialize a pha rmaceutical product or compound owned by it or to which it has rights, taking into account its market potential and the stage in its development or prod uct life, relevant issues of safety and efficacy, product pro file and labeling, other medical and clinical consi derations, difficulty in developing the product or compound, c ompetitiveness of the marketplace for the applicabl e product(s ) marketed or to be marketed, the propriet ary position of the compound or product, the regula tory structure involved, the potential profitability of the applicable product(s ) marketed or to be markete d, and other relevant factors affecting the cost, risk and timin g of Development and the total potential reward to be obtained if a product is Commercialized . Such efforts and resou rces that are used by PRESIDIO ’s Affiliates and Thi rd Party sublicensees shall be attributed to PRESIDIO for pu rposes of this Agreement