definiens: means, with respect to a Research Program obligation, Compound or Product, those efforts and resources that the party required to make such efforts generally uses ( as applicable in the context used in this Agreement ) in researching, developing, seeking regulatory approvals, manufacturing, promoting, detailing and marketing its other pharmaceutical products that are comparable to the applicable Compound(s ) or Product(s ), or in carrying out its other research programs relating to such comparable products, taking into account product labeling or anticipated labeling, market potential, past performance ( if any ), economic return potential, medical and clinical considerations, the present and future regulatory environment, and competitive market conditions in the therapeutic area, all as measured by the facts and circumstances at the time such efforts are due, but without taking into account any payment obligations to the other party under this Agreement and, with respect to [COMPANY] 's efforts and resources, without taking into account considerations relating to Excluded [COMPANY] Compounds