definiens: shall mean, with respect to the eﬀorts to be expended by a Party with respect to any objective, thelevel of reasonable, diligent, good faith eﬀorts that biopharmaceutical companies typically devote to products owned by them that are at a similar stage intheir development or product life and are of similar market potential taking into account eﬃcacy, safety, approved labeling, the competitiveness ofalternative products in the marketplace, the patent and other proprietary position of the product, the likelihood of regulatory approval, the proﬁtability ofthe product, and other relevant factors . As used in this Section 1.15, shall mean companies in the biopharmaceuticalindustry of a size and stage of development similar to that of such Party, including having human pharmaceutical product candidates or products in asimilar stage of development to the Molecule . Commercially Reasonable Eﬀorts shall be determined on a market - by - market and Product - by - Productbasis, and it is anticipated that the level of eﬀort will be diﬀerent for diﬀerent markets, and will change over time, reﬂecting changes in the status of theProduct and the market(s ) involved