definiens: means, with respect to a Party, a commitment by o r on behalf of such Party of a level of resources, effor ts and urgency to Research, Develop, Manufacture an d Commercialize ( as applicable ) a Collaboration Produ ct applied by such Party that is commensurate with those resources, efforts and urgency used in the biotechn ology industry by a company of comparable size in connection with the research, development, manufact uring and commercialization of biotechnology produc ts of a similar stage of product life, taking into accoun t the proprietary position of the product ( includin g intellectual property scope, subject matter and coverage ), safet y, efficacy, product profile, competitiveness of th e marketplace, the regulatory status and approval pro cess, anticipated or approved labeling, present and future market potential, the probable profitability of the applicable product ( including pricing and reimburs ement status achieved or likely to be achieved ) and other releva nt factors such as technical, legal, scientific or medical factors