definiens: means, with respect to the efforts and resources to be expended by a Party with respect to the Compound and Product hereunder, the level of efforts and resources cons istent with the efforts and resources a pharmaceutical com pany of similar size and situation in the exercise of its reasonable business judgment typically devotes to i ts own product candidates of similar market potenti al, at a similar stage in development or 6 Confidential EXECUTION VERSION product lifecycle, taking also into account the sta ge of development or product lifecycle of other pro ducts in such Party ’s portfolio candidates, issues of safety and efficacy, product profile, the proprietary position of the Compound and Product, cost of goods, the competitiv eness of the marketplace, the regulatory structure involved, the likelihood of regulatory approval, the anticipa ted or actual profitability of the applicable produ ct, and other technical, legal, scientific and medical considerat ions ; provided, that in any event each Party shall use no less than those efforts it uses with respect to its othe r high priority assets . Without limiting the forego ing, Commercially Reasonable Efforts requires, with resp ect to such obligations, that the Party : ( a ) prompt ly assign responsibility for such obligation to specific empl oyee(s ) who are held accountable for progress and m onitor such progress on an on - going basis, ( b ) set objecti ves for carrying out such obligations, and ( c ) allo cate resources designed to advance progress with respect to such o bjectives