definiens: is definedaslWg,·ffi ~ t ~ iit··W ~ s;~;.~,o,'tQ ~ Q;rQ;;5;8(14:;~.8'7 ~ dthe ' j ~ f)';~{~~lr~;~~W ~ i\~ ', · •.•• · .:·~FAtS - Optimized Mutants ., of ( Jree ~ Flqor ~ sceI1rPrQtein';'ahd""FlU6fescente - based Isolation of Differentially lridu ~ GeQe$~;~ ~ Section 3.Ll of the Research and License Agreement shall be amended to replace the first paragraph thereof with the new paragraph attached as Exhibit A to this Secon ? Amendment . In ~ last SUb~, .,, > C, .~h ( i, i,,),Of ~ ection 3,l,,1 ofth~ Research and ~cense Agreement, ~e wor ~ neof the three','ESP Screens~ replaced, / with ' one of the two ESP Screens Auro " ~creen development obligations under said Section 3 .1.1 have been satisfied . Exhibit 3.1.1 of the Research and License Agreement shall be amended througho to replace with 3 . Section 3.2 of the Research and License Agreement shall be amended and replaced in its entirety with a new Section 3.2 attached as Exhibit B to this Second Amendment