definiens: means ( a ) any and all renal, cardiovascular and diabetes indications, including ( i ) renalinsufficiency, chronic kidney disease, acute kidney failure, ischemia - reperfusion injury of the kidney, glomerulonephritis, and all other forms of nephritis ( whether acute or chronic ) ; ( ii ) atherosclerosis, heart failure, myocardial infarction, acute coronary syndrome, myocarditis, angina, restenosis, aneurysms, vasculitis, complications of vascular surgery and heart surgery, thrombosis, phlebitis, peripheral vascular disease, andhypertension ; and ( iii ) the following metabolic diseases : type II diabetes, insulin resistance, complications of diabetes(including retinopathy, neuropathy, and ulcers ), obesity, metabolic syndrome, hypercholesterolemia, andhyperlipidemia, and ( b ) any indications added to this Agreement in accordance with Section 13.5.1 . For the avoidanceof doubt, unless added to this Agreement in accordance with Section 13.5.1, Indication does not include anyindications for : ( i ) any forms of cancer ; ( ii ) any forms of organ failure ( other than renal failure or heart failure);(iii ) respiratory disorders ; ( iv ) allergies and autoimmune diseases ; ( v ) neurological, psychiatric, or neuropsychiatricdisorders ( other than diabetic neuropathy ) ; ( vi ) infectious diseases ; ( vii ) skin diseases ( other than diabetic ulcers);(viii ) gastrointestinal disorders ; ( ix ) bone or cartilage disorders ; ( x ) musculoskeletal disorders ; ( xi ) eye diseases ( otherthan diabetic retinopathy ) ; ( xii ) human immunodeficiency virus - associated complications ; and ( xiii ) sepsis ; providedthat the foregoing exclusions will not limit [COMPANY] Kirin from marketing or selling Licensed Products for licensedIndications, even if the use of a Licensed Product may have an incidental therapeutic benefit for one of the excludedindications, but in no event shall [COMPANY] Kirin be authorized to seek separate regulatory approval for any indicationthat is outside the licensed Indications