definiens: means the gross amounts billed or invoiced by Eyetech, its affiliates and sublicensees for EYE001 worldwide, less the followi ng deductions : ( a ) trade, quantity and cash discounts al lowed, but expressly excluding discounts or allowan ces offered as part of a package of products that inclu des EYE001 sold by Eyetech, its affiliates or sublicensees ; ( b ) refunds, chargebacks and any other al lowances which effectively reduce the net selling p rice ; ( c ) actual product returns, credits and a llowances allowed to customers, and actual bad debt s ; ( d ) rebates actually paid or credited to any governmental agency ( or branch thereof ) or to a ny third party payor, administrator or contractee ; ( e ) discounts mandated by, or granted to meet the requirements of, applicable state, provinc ial or federal law, wholesaler, including required chargeb acks and retroactive price reductions ; ( f ) transportation, freight, postage cha rges and other charges, such as insurance, relating thereto, in each case included as a specific line item on an invoice to such third parties ; and ( g ) taxes, excises or other governmental charges upon or measured by the production, sale, transportation, delivery or use of goods, in each c ase included as a specific line item on an invoice to such third parties