definiens: means Alzheimer ’s Disease ( based upon ante mortem d iagnostic evaluations in use as of the Effective Date ) . ” ; ( b ) deleting Section 7.2(b ) in its entirety and replaci ng it with ; and ( c ) deleting each reference to or and replacing it with a referen ce to ; [COMPANY], Inc.  200 East First Street, Suite 300  Winston - Salem, NC 27101 -4165 Telephone 336.480.2120  Fascsimile 336.480.2103  E - mail don.debethizy@targacept.com ( 3 ) agrees with the other that the Second Agreement shall be amended by : ( a ) deleting Section 1.29 in its entirety and replacing it with the following : means any of the following indications : ( a ) Alzheimer ’s Disease ( based upon ante mortem diagnos tic evaluations in use as of the Effective Date ) ; or ( b ) any other disorder of the central nervous system . F or the avoidance of doubt, each disorder o f the central nervous system shall be a separate Indi cation for all purposes, including without limitation milestone payments pursuant to Section 7 .1 . ” ; ( b ) deleting Section 1.54 in its entirety and replacing it with the following : means Alzheimer ’s Disease ( based upon ante mortem diagnostic evaluations in use as of the Effective D ate ) . ” ; ( c ) deleting each reference to or and r eplacing it with a reference to ; and ( d ) adding to Exhibit B thereto ; and ( 4 ) agrees with the other that : ( a ) it is the intent of this Amendment Letter that the First Agreement has only one ( as defined therein ) and that, if the First Agreement i s terminated as to such Indication, it shall be terminated in its entirety ; ( b ) it is the intent of this Amendment Letter that the Second Agreement have only one ( as defined therein ) ; and ( c ) except as expressly amended in this Amendment Lette r, each of the Agreements shall continue in full force and effect in accordance with its terms