definiens: means the carrying out of discovery, research, de velopment or commercialization activities using good - faith comme rcially reasonable and diligent efforts that the ap plicable Party would reasonably devote to a compound or prod uct of similar market potential or profit potential at a similar stage in development or product life resulting from its own research efforts, based on conditions then prevailing and taking into account, without limitation, issues of safety and efficacy, regulatory authority - appro ved labeling, product profile, the competitiveness of alternative products in the marketplace ( including Spinraza ® ), the likely timing of the product ’s entry into the market, the patent and other proprietary position, the likeliho od of Approval and other relevant scientific, technical and commer cial factors . Without limiting any of the foregoing, Commercially Reasonable Efforts as it applies to Bi ogen ’s Development or Commercialization of a Produc t hereunder includes the use of Commercially Reasonab le Efforts to perform the described in [ * * * ], and Commercially Reasonable Efforts as it applies to Io nis ’ performance hereunder includes use of Commerci ally Reasonable Efforts to [ * * * ]