definiens: shall mean histone deacetylase and shall include without limitation any one of a family of enzymesthat remove acetyl groups from amino groups of lysine residues at the N - terminus of a histone, including but notlimited to HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDAC10, HDAC11, SIRT1,SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7, and any histone deacetylase as described or referenced in MG ’s patentapplication WO2003024448A2, or the articles Nature Reviews, Drug Discovery, 1, 287 - 299 ( 2002 ) or J. Biol . Chem .,277, 25748 - 55 ( 2002 )