definiens: or means the inhibition or activation of a Coagulation Cascade Protein using a ShortActing Coagulation Cascade Aptamer . As used in this definition, means either ( a ) inhibition at a therapeuticallyuseful level of a Short Acting Coagulation Cascade Aptamer by binding of a Short Acting Coagulation Cascade Aptamer to apre - selected Coagulation Cascade Protein or ( b ) inhibition at a therapeutically useful level of a Short Acting CoagulationCascade Aptamer of a second pre - selected Coagulation Cascade Protein by binding at a therapeutically useful level of a ShortActing Coagulation Cascade Aptamer to a first pre - selected Coagulation Cascade Protein . As used in 8.this definition, means either ( a ) activation at a therapeutically useful level of a Short Acting CoagulationCascade Aptamer by binding of a Short Acting Coagulation Cascade Aptamer to a pre - selected Coagulation Cascade Proteinor ( b ) activation at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer of a second pre - selectedCoagulation Cascade Protein by binding at a therapeutically useful level of a Short Acting Coagulation Cascade Aptamer to afirst pre - selected Coagulation Cascade Protein