definiens: shall mean, with respect to the Commercialization Activities that aParty is required to perform with respect to the Combination Product pursuant to the Commercialization Plan, the levelof effort that would generally be used by a Party to conduct such commercialization activities in a manner consistentwith the minimum level of expenditure contemplated for such activities by the Commercialization Budget for a productor compound owned by it or to which it has rights, which is of comparable market potential, profit potential or strategicvalue to such Party and is at a similar stage in its development or product life, taking into account, without limitation, issues of safety and efficacy, product profile, the proprietary position, the then - current competitive environment for [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEENOMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OFTHE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED