definiens: means ( i ) any use of inhibitors for human PNP that have an IC value less than * * *, as determined by themethod described in Bantia, et al ., Immunopharmacology, 35, page 54, paragraph 2.1 ( 1997 ) and ( ii ) any antiviral use of BCX-4430, including but not limited to prophylactic antiviral and therapeutic antiviral uses . Except for those compounds which arealso inhibitors for human PNP as described above, specifically excluded from the are inhibitors for MTAP and / orMTAN and processes for producing and using such inhibitors to inhibit MTAP and/or MTAN . An inhibitor for the humanMTAP enzyme is defined as having a Ki or Ki * value of * * * or less using the assays with human MTAP published inBiochemistry 2004, 43, 9 - 18, page 10 . An inhibitor for the bacterial MTAN enzyme is defined as having a Ki or Ki * value of * * * or less using the assays with E. coli MTAN published in the Journal of Biological Chemistry 2005, 280:18265 - 18273,page 18268 . Non - limiting examples of excluded inhibitors are the compounds listed below :* * * 2 . The following new Paragraph 1.09 is hereby added to the License Agreement:501.09 means the compound known as BCX-4430 having the following chemical structure * * * together with its isomers, positional isomers, radioisomers, salt forms, anhydrides, hydrates, polymorphs, metabolites, prodrugsand ester forms