definiens: means, with respect to a Party performing any obligation under this Agreement, the carrying out o f such obligation with efforts that are consistent with the level of efforts and resources used by such Party in the exercise of its commercially reasonable business pr actices for a similar activity, including, with respect to the De velopment or Commercialization of a Resulting Compo und or Product under this Agreement, the Development or Co mmercialization, respectively, of a pharmaceutical or biologic compound or product, as applicable, that i s at a similar stage in its research, development o r commercial life as the relevant Resulting Compound or Product based on conditions then prevailing, in view of all costs and risks relevant to such Resulting Compound or Produc t and subject to [ * * * ], and that has commercial, pr ofit or market potential, or strategic value similar to tha t of the relevant Resulting Compound or Product, ta king into account issues of intellectual property coverage, s afety and efficacy, applicable Law, stage of develo pment or product life based on conditions then prevailing, p roduct profile, the then - current competitive enviro nment for such Resulting Compound or Product and the likely t iming of such Product ’s entry into the market, the proprietary position, the regulatory environment an d status of the Product ( including regulatory exclu sivity ), anticipated or approved labeling, present and futur e market and commercial potential, the likelihood o f receipt of Regulatory Approval and other regulatory requiremen ts, profitability ( including pricing and reimbursem ent status achieved or likely to be achieved ), legal is sues and Manufacturing, and other relevant scientif ic technical and commercial factors . Commercially Reasonable Eff orts shall be determined on a country - by - country, Resulting Compound - by - Resulting Compound, Product - b y - Product basis and Indication - by - Indication basis, and it is anticipated that the level of effort will cha nge over time, reflecting changes in the status of the Product and the market(s ) or country(ies )