definiens: means, with respect to the commercialization of each LicensedProduct, at any given time as the case may be, efforts reasonably used by Purchaser or its Affiliates ( giving dueconsideration to relevant industry standards ) for Purchaser ’s own products ( including internally developed, acquired andin - licensed products ) with similar commercial potential at a similar stage in their lifecycle ( assuming continuingdevelopment of such product ), taking into consideration their safety, tolerability and efficacy, and theradioimmunotherapy nature of the Licensed Products, the profitability on a GAAP basis consistent with Purchaser’spublicly reported financial statements, the competitive landscape, extent of market exclusivity, patent protection, cost todevelop the product, promotable claims, health economic claims, the approved indications and the regulatory andreimbursement structure involved . This Section 10.6 shall have no further force or effect with respect to the LicensedProducts once Purchaser no longer has any obligation to make payments to [COMPANY] with respect to net sales of suchLicensed Product under Section 4.3.1