definiens: means the discovery, isolation, characterisation, research, development, and/or commercialisation of an Antibody useful for the diagnosis, treatment andlor prevention of one or more of the following disease conditions wherein the primary scientific rationale or activity is neuronal andlor glial mechanisms of action or neuroprotection : ( a ) neurodegenerative conditions, including but not limited to ( i ) Alzheimer 's disease, and ( ii ) Parkinson 's disease, but in both instances, excluding the WRAGGE2 # 3700520 vI [ PCD]/[LED ] treatment and/or prevention ofneurodegenerative conditions in humans associated with ~-amyloid deposition ( including, without limitation, Alzheimer 's disease and/or Mild Cognitive Impaimlent, using either ( A ) immunological approaches directed at one or more epitopes of A~ or any naturally occurring variants thereof, including, without limitation, the administration of an Antibody, or ( B ) use of a beta secretase inhibitor, including, without limitation, the administration of an Antibody ) ; ( b ) diabetic neuropathy ; ( c ) pain, including, but not limited to, ( i ) post - operative pain, ( ii ) chronic pain and ( iii ) neuropathic pain, ( d ) spinal cord injury ; ( e ) multiple sclerosis ; and/or ( f ) stroke, as a disease ofthe cerebrovasculature, provided, however, that for the purpose of this Agreement, the term shall not include the diagnosis, treatment and/or prevention of the above disease conditions caused by infectious pathogenic micro - organisms