definiens: . 2 . Article 1.14 of the Agreement shall be amended to read as follows : shall mean use for the diagnosis, treatment and prevention of gonadotropin, gonadal steroid hormone(s ) or GnRH receptor(s ) associated diseases and cancers in humans including but not limited to endometriosis, polycystic ovaries, uterine fibroids, contraception, infertility, precocious puberty, prostate cancer, breast cancer, ovarian cancer and endometrial cancer, either alone or in combination with chemotherapy . " 3 . The sixth sentence of Section 3 . 1 . ( ii ) ofthe Agreement, as previously revised through Amendment No.1, shall be further amended to read as follows : APH0045 4 . The first sentence of Section 13.3.1 of the Agreement, as previously revised through Amendment No.1, shall be further amended to read as follows : " Prior to the Acceptance Date, [COMPANY] shall have the right to terminate this Agreement by serving notice of no less than 30 days to Apthon which will be effective at the earlier of ( a ) twenty - seven ( 27 ) months after the Delivery Date ( defined in 3.1 ( i ) ) or ( b ) as from September 30, 2002 . " 5 . This Amendment is limited as specified and shall not constitute a modification, acceptance or waiver of any other provision of the Agreement . For the avoidance of doubt, the extension of the Presentation Date of the Agreement shall not imply an extension by any means of the Put Option period or Call Option period of the Subscription Agreement, which forms Schedule C of the Agreement, which periods remain governed by the provisions of Section 3 of the Subscription Agreement