definiens: shall mean, with respect to a Product Candidate and a particular PermittedIndication, Development activities conducted with respect to such Product Candidate under the R&D Plan in order toadjust the composition of such Product Candidate to optimize the safety or efficacy of such Product Candidate forsuch Permitted Indication prior to the Initiation of a POC Trial . shall include the following activities : ( a ) [ * * * ] the Compound Candidate included in such Product Candidate ; ( b ) [ * * * ] the Compound Candidate included insuch Product Candidate, such [ * * * ] then comprising the Compound Candidate, ( c ) [ * * * ] in the Compound Candidateincluded in such Product Candidate ; ( d ) [ * * * ] to the Compound Candidate or [ * * * ] from the Compound Candidate, ineach case included in such Product Candidate ; or ( e ) [ * * * ] the Compound Candidate included in such ProductCandidate, including [ * * * ]