definiens: means, with respect to the efforts and resources to be expended by a Party with respectto the Compound and Product hereunder, the level of efforts and resources consistent with the efforts and resources a pharmaceuticalcompany of similar size and situation in the exercise of its reasonable business judgment typically devotes to its own product candidates ofsimilar market potential, at a similar stage in development or product lifecycle, taking also into account the stage of development or productlifecycle of other products in such Party ’s portfolio candidates, issues of safety and efficacy, product profile, the proprietary position of theCompound and Product, cost of goods, the competitiveness of the marketplace, the regulatory structure involved, the likelihood of regulatoryapproval, the anticipated or actual profitability of the applicable product, and other technical, legal, scientific and medical considerations;provided, that in any event each Party shall use no less than those efforts it uses with respect to its other high priority assets . Withoutlimiting the foregoing, Commercially Reasonable Efforts requires, with respect to such obligations, that the Party : ( a ) promptly assignresponsibility for such obligation to specific employee(s ) who are held accountable for progress and monitor such progress on an on - goingbasis, ( b ) set objectives for carrying out such obligations, and ( c ) allocate resources designed to advance progress with respect to suchobjectives