definiens: means ( i ) [ JNKl, the human wild type MAPK8 ( mitogen - activated protein kinase 8) polypeptides with the sequences described in NCBI Reference Sequences NP _ 002741, NP_620634, NP_62063S, and NP _ 620637, and ( ii ) ( a ) JNK2, the human wild type MAPK9 ( mitogen - activated protein kinase 9 ) polypeptides with . the sequences descrIbed in NCBI Reference Sequences NP _ 002743, NP ~620707, NP_620708, . and NP .... ; 620709, and/or ( b ) JNK3, tbe huulan wild type MAPKIO ( mitogen - activated protein kinase to ) polypeptides with the sequences described in NCBI Ret'er.ence Sequences NP _ 002144, NP _ 620446, NP _ 620447, and NP .... ;620448 ]