definiens: or means any of the following, as applicable, and to the extent agreed by the JSC following the Effective Date, and which may be amended from time to time by the JSC pursuant to Section 4.2.3 : ( a ) the initial dev elopment plan governing the research and Development activities to be conducted by the Parti es as part of the Collaboration with respect to ICO S ( solely with respect to Collaboration Candidates that are I mmune Activators ), including pre - clinical work and Clinical Trials for JTX-2011 through the Evaluation of POC ( the ) ; ( b ) the initial dev elopment plan governing the research and Development activities to be conducted by the Parti es as part of the Collaboration with respect to JTX -4014, including pre - clinical work and [ * * * ] ( the ) ; ( c ) the initial de velopment plan governing the research and Development activities to be conducted by the Parti es as part of the Collaboration with respect to the Pre - Clinical Collaboration Candidates and Development C andidates Specifically Directed against the Availab le Macrophage Targets and/or Available B - Cell / Treg Tar gets until the first IND for a Collaboration Candid ate Specifically Directed against one ( 1 ) of the Availa ble Macrophage Targets and/or Available B - Cell / Treg Targets is filed ( in which case, the remaining Available Ma crophage Targets and/or Available B - Cell / Treg Targe ts shall no longer be included in such plan, but instead sha ll be included in an Other IDP ), including all pre- clinical work, [ * * * ] ( the ) ; ( d ) the initial dev elopment plans governing the research and Development activities to be conducted by the Parti es as part of the Collaboration with respect to all Other Programs except the Available Macrophage Target or Available B - Cell / Treg Target that is the subject of the Lead IDP, including pre - clinical work ( an ) ; and or shall mean all of the foregoing