definiens: means : ( i ) the com position of REAGENTS ( including SELECTED REAGENT ) ; ( ii ) methods of using REAGENTS ( including SELECTED REAGENT ) by themselves or in combination ; ( iii ) methods of making, processing, analyzing or characterizing REAGENTS ( i ncluding SELECTED REAGENT ) or products ( including SELECTED PRODUCT ) i ncorporating REAGENT by means of covalent chemical bonding ; ( iv ) methods of attaching one or more REAGENTS ( including SELECTED REAGENT ) to or associa ting one or more REAGENTS ( including SELECTED REAGENT ) with or to an y therapeutic agent ( including the THERAPEUTIC AGENT ) ; ( v ) methods of d irecting or determining the point of attachment of one or more REAGENTS ( in cluding SELECTED REAGENT ) to or associating one or more REAGENTS ( in cluding SELECTED REAGENT ) with any therapeutic agent ( including the THERAPEUTIC AGENT ) ; ( vi ) the chemical structure of product ( including t he chemical structure of SELECTED PRODUCT ) obtained by attaching or associat ing one or more REAGENTS ( including by PEGYLATION and including SELECTED REA GENT ) to or with any therapeutic agent ( including the THERAPEUTIC AGENT ) but for the avoidance of doubt, excluding the chemical structure and comp osition of THERAPEUTIC AGENT ; and ( vii ) methods of making, formulating, co mbining, processing, using, analyzing or characterizing two ( 2 ) or more REAGENTS ( including SELECTED REAGENT ) in combination