definiens: shall mean any product ( comprising, for example, an agent, chemical entity(including a small molecule ), compound, moiety, mixture of chemical compounds and/or molecules, molecule ( includingbiological macromolecules such as proteins, carbohydrates, peptides and nucleic acids ), or an extract ) that partially orfully blocks, inhibits, or neutralizes ( i ) the binding between Alpha-4 Integrin and one of its ligands, such as VCAM-1,fibronectin or MadCAM, including by competitive or allosteric binding to Alpha-4 Integrin, one or more of its subunits, one of its ligands and/or one or more of their subunits, and/or ( ii ) Alpha-4 Integrin - mediated cell migration and / oradhesion . Notwithstanding the foregoing, Alpha-4 Integrin Products shall not include a product whose half maximalinhibitory concentration is 10 µM or higher . Assays which can be used to assess binding and functional activity include(1 ) Michael P. Bova, et . al ., 2011 J Biomol Screen, June 2011 ; vol . 16, 5 : pp . 536 - 544 ; ( 2 ) WO 2007/041324 A1 ( Example A ) ; ( 3 ) WO2006/127584 A1 ( Biological Example A ) ; or ( 4 ) Piraino, et . al ., 2002 “ Prolonged Reversal of Chronic ExperimentalAllergic Encephalomyelitis Using a Small Molecule Inhibitor of alpha-4 Integrin ”, J Neuroimmunol, ( 2002 ) vol . 131, pp