definiens: meanu molecule which is created by or for [COMPANY] based on a Hit identified in a Collaborative Screen and which exhibits activity of the kind and direction ' I : intended to be detected by such Collaborative Screen including ( i ) a molecule based on the structure of a Hit ( or anyone of the substantial substructures, if more than one exist ), ( ii ) a molecule with a structure substantially based on data derived from a Hit or ( iii ) a molecule with a structure that falls within the scope of any Valid Claim owned or Controlled by [COMPANY] that encompasses a Hit . It is understood that a Derivative may be a molecule derived from another Derivativ9 1.31 means§y Hit or Derivative that is designated as a safety assessment candidate or the equivalent by [COMPANY] 's Safety Assessment Review Committee, or successor committee, and is continned by [COMPANY] 's Research Management Committee, or successor committee, as may be reflected in the minutes of the relevant committee meetings . In the event that a Hit or Derivative reaches an IND submission without being confirmed as a safety assessment candidate by [COMPANY] 's Research Management Committee, such Hit or Derivative will be deemed a Development Candidate for purposes of this Agreement . Notwithstanding the foregoing, to be a the Hit or Derivative must be developed for the activity of the kind and direction intended to be detected by the relevant Collaborative Screen ( i.e. the Collaborative Screen used to identify the Hit or Derivative on which such Development Candidate is basectg 1.32 means December 18, 1997