definiens: means costs and expensesthat are incurred after the Effective Date by either party and AffiliatedSubcontractors in performing Biotherapeutics Research activities in accordancewith an applicable Biotherapeutics Research Plan and associated budget approvedby the Joint Management Committee, including : ( a ) the costs of internal scientific, medical, technical and managerial personnel engaged in Biotherapeutics Research activities ( together with all associated laboratory supplies, facilities and occupancy costs ), which costs shall be determined based on FTE Costs, unless another basis is otherwise agreed upon by the parties in writing ; ( b ) out - of - pocket expenditures directly related to such Biotherapeutics Research activities, including payments to contract research organizations, consultants and other subcontractors, subject to Section 2.2.4 ; and ( c ) any other costs expressly provided for and actually incurred in accordance with such Biotherapeutics Research Plan