definiens: means with respect to the effortsto be expended by a Party with respect to any objective, those reasonable, good faithefforts to accomplish such objective as such Party would normally use to accomplisha similar objective under similar circumstances . With respect to any efforts relating tothe Development, Regulatory Approval, Manufacture or Commercialization of aProduct by a Party, generally or with respect to any particular country in the Territory, a Party will be deemed to have exercised Commercially Reasonable Efforts if suchParty has exercised those efforts normally used by such Party, in the relevant country, with respect to a product or product candidate of similar modality owned or controlledby such Party, or to which such Party has similar rights, which product or productcandidate is of similar market potential in such country, and is at a similar stage in itsdevelopment or product life cycle as the Product, taking into account all RelevantFactors in effect at the time such efforts are to be expended . To the extent that theperformance of a Party ’s obligations hereunder is adversely affected by the otherParty ’s failure to perform its obligations hereunder, the impact of such performancefailure will be taken into account in determining whether such Party has used itsCommercially Reasonable Efforts to perform any such affected obligations