definiens: means ( a ) any Know - How Controlled by Miragen, its Affiliates or Sublicensees at any time during the Term and prior to the termination of this Agreement with respect t o a Terminated Miragen Target [ * ] ; and ( b ) any Patents Controlled by Miragen, its Affiliates or Sublicensees at any time during the Term, in each c ase that ( i ) are necessary to Develop, [ * ] or Commercialize any Reversion Product and ( ii)(A ) are actually used or practiced by Miragen, its Affiliates or Sublicensees with respect to the Deve lopment, [ * ] or Commercialization of such Reversion Product prior to the applicable effective date of termination for such Terminated Miragen Target [ * ] or by Santaris, its Affiliates or sublic ensees with respect to the Development, [ * ] or Commercialization of such Reversion Product prior t o first dosing of the first patient in the first Ph ase III Clinical Trial of such Reversion Product, or ( B ) at the applicable effective date of termination fo r such Terminated Miragen Target [ * ] or at the time o f the first dosing of the first patient in the firs t Phase III Clinical [ * ] = Certain confidential information contained in this document, marked by brackets, is filed with t he Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended