definiens: means a gen e target within the Field of Use having ( i ) a nucleotide sequence for a particular modality, and ( ii ) functional optimizations of such nucleotide sequence that are ( a ) within a [ * * ] % identity of such nucleotide sequence or [ * * ] % identity of the amino acid sequence of a protein encoded by such nucleotide sequence ( each a ), ( b ) truncations of such nucleotide sequence or any [ * * ] % sequence, or ( c ) fusions of such nucleotide sequence or any [ * * ] % sequence . For the purposes of this definition, are defined as modifications to a nucleotide sequence that retain the primary mechanism of action of such nucleotide sequence or a protein encoded by such nucleotide sequence and increase the primary functionality or applicabilit y of such nucleotide sequence of the protein encoded by such nucleotide sequence . For the avoidance of doubt, a gene target may be a Licensed Gene Target even if such target is known to have other utility with respect to the use thereof outside the Field o f Use as well as within the Field of Use . By way of non - limiting example, the following gene targets are for purposes of this Agreement : [ * * ]