definiens: means Patents Controlled by a Regulus Collaborator that claim:(i ) any invention that is conceived or reduced to practice during the [ … * * * … ] years following Regulus ’ grant of asublicense under the [COMPANY] Blocking Patents to such Regulus * * * Confidential Treatment Requested5.Collaborator by one or more employees of such Regulus Collaborator or any of its Affiliates who ( A ) have participated in anycollaboration activities with Regulus pursuant to a license from Regulus under the Regulus Platform Technology or ( B ) haveotherwise received Regulus Platform Technology ( excluding any Regulus Platform Know - How that, at the time of initialaccess by any such employee, was not confidential information of Regulus ) ; and(ii ) either:(a ) microRNA Compounds in general;(b ) chemistry or delivery technology useful in connection with microRNA Compounds;(c ) general mechanisms of action by which a microRNA Compound modulates microRNA ; or(d ) general methods of treating or preventing an Indication by modulating one or more microRNAs;provided, however, that in each case, Regulus Collaborator Blocking Patents exclude Patents Controlled by the applicableRegulus Collaborator ( in each, case other than as a result of the sublicense granted by Regulus ) to the extent that such Patentsclaim:(1 ) a microRNA sequence or a portion thereof;(2 ) the specific compositions of matter of any microRNA Compound ; or(3 ) methods of using as a therapeutic any microRNA Compound