definiens: with correlative meanings or to, means covalent chemical bonding of any REAGENT ( including a SELECT ED REAGENT and including covalent chemical bonding through linkin g groups ), with or to another material or materials . Such materials include, without limitation, proteins, peptides, po lymers, oligomers, oligonucleotides, other biomolecules, small molecules, therapeutic agents ( including a THERAPEUTIC AGENT ), diagnostic agents, imaging agents and detectable labels . Addit ional materials that may be PEGYLATED include, without limitation, polymers, liposomes, films, che mical separation and purification surfaces, solid supports, metal / metal oxide surfaces and other surf aces s uch as, by way of example but not limitation, those on implanted devices, and equipment, where a REAGENT is covalently chemically bonded to one or more reactive molecules on the surface of such d evice or equipment . shall include the synthesis, derivatization, characterization, and modification of PEG for such purposes, together with the synthesis, derivatization, characterization, an d modification of the raw materials and intermediat es for the manufacture of REAGENTS ( including SELECTED REAGENT S ) or products ( including POTENTIAL PRODUCTS and COMMERCIAL PRODUCTS ) incorpo rating such REAGENT by means of covalent chemical bonding, and all methods of making and using each and all of the foregoing