definiens: shall mean all inventions ( whether or not patentable ), discoveries, methods, compositions and other trade secrets and know - how ( collectively ) that are conceived or first reduced to practice by [COMPANY], solely or jointly with others, ( i ) during the Term, ( ii ) [ based upon or as a result of access to [COMPANY] Intellectual Property or products provided under this Agreement or the Related Agreements, and ( iii ) to the extent they are ] direc!ed to the design, development or manufacture of micro fluidic chips or chip interfaces . For purposes of ( iii ), means that the Improvement does [ not have a material practical application other than ] with regard to micro fluidic chips . means the [ first tier physical and optical ] interface between a micro fluidic chip and associated hardware . specifically include, but are not limited to, ( a ) chip designs and formats, ( b ) the chip cartridge design, ( c ) how the actuation forces ( e.g., pressure, electrical ) are applied to the chip, ( d ) physical or chemical methods for measuring temperature in channels, ( e ) Improvements directed to the Library Card System and ( f ) methods of controlling physical conditions for reagents on the chip ( e.g. control of evaporation and temperature in on - chip reservoirs, or control of temperature or pressure in chip channels ) . For purposes of ( e ), means that the Improvement does [ not have a material practical application other than ] with regard to Library Card Systems . specifically exclude, among other things, Target Assay Protocols