definiens: means the arrangement under the provisions of Section 192 of the CBCA, on the terms andconditions set out in this Plan of Arrangement, subject to any amendments or variations thereto made inaccordance with Section 8.6 of the Arrangement Agreement or Article 7 of this Plan of Arrangement or madeat the direction of the Court in the Final Order with the consent of [COMPANY], [COMPANY] and Cipher, each actingreasonably;(b ) means the agreement made as of March 19, 2018 between [COMPANY], Correvioand Cipher, including the schedules thereto, as the same may be amended, supplemented or otherwisemodified from time to time;(c ) means the special resolution of the [COMPANY] Shareholders approving theArrangement, this Plan of Arrangement and the Arrangement Agreement to be considered at the CardiomeMeeting;(d ) means the articles of arrangement of [COMPANY] in respect of the Arrangement, tobe filed with the Director after the Final Order is made;(e ) means all patents, trademarks and goodwill owned by [COMPANY] related to the Brinavessproduct and the royalty agreement between [COMPANY] International Sarl and [COMPANY] with respect to royaltieson non - Canadian Brinavess, but not including any Canadian patents, trademarks and goodwill related to theBrinavess product;(f ) means any day of the year, other than a Saturday, Sunday or any statutory holiday inToronto, Ontario or Vancouver, British Columbia;(g ) means [COMPANY] Pharma Corp., a corporation existing under the federal laws of Canada;(h ) means the special meeting of the Shareholders, including any adjournment orpostponement thereof, to be called and held in accordance with the Interim Order for the purpose ofconsidering and, if thought fit, approving the Arrangement Resolution;(i ) means the common shares in the capital of Cardiome;(j ) means the letter of transmittal to be delivered by [COMPANY] to theShareholders providing for the delivery of [COMPANY] Shares to the Depositary;(k ) means the Canada Business Corporations Act, including all regulations made thereunder;(l ) means Cipher Pharmaceuticals Inc. ; ( m ) means the consideration to be received by Shareholders ( other than DissentingShareholders ) for their [COMPANY] Shares pursuant to this Plan of Arrangement, consisting of one ( 1 ) CorrevioShare for each one ( 1 ) [COMPANY] Share in accordance with the Exchange Ratio ( subject to any adjustment ofthe Exchange Ratio);(n ) means [COMPANY] Pharma Corp., a corporation incorporated under the CBCA, that is and will be awholly - owned subsidiary of [COMPANY] immediately prior to the Effective Time;(o ) means a corporation to be incorporated under the CBCA, that is and will be a wholly - owned subsidiary of [COMPANY] immediately prior to the Effective Time;(p ) means issued and outstanding common shares in the capital of [COMPANY] Canada;(q ) means an option to purchase from [COMPANY] one ( 1 ) [COMPANY] Share ( subjectto any adjustment of the Exchange Ratio ) . Each [COMPANY] Replacement Option shall provide for an exerciseprice per [COMPANY] Replacement Option ( rounded up to the nearest whole cent ) equal to the exercise price perCardiome Share that would otherwise be payable to acquire a [COMPANY] Share pursuant to the Option itreplaces . All terms and conditions of a [COMPANY] Replacement Option, including the term to expiry, conditionsto and manner of exercising, will be the same as the Option for which it was exchanged, and shall begoverned by the terms of the [COMPANY] Stock Option Plan and any document evidencing an Option shallthereafter evidence and be deemed to evidence such [COMPANY] Replacement Option;(r ) means common shares in the capital of Correvio;(s ) means an incentive stock option plan of [COMPANY], having identical terms andconditions to the Stock Option Plan, except all references to [COMPANY] shall be references to [COMPANY] andwith such other changes as approved by the board of directors of [COMPANY] and validly approved by theShareholders at the [COMPANY] Meeting;(t ) means the Supreme Court of British Columbia;(u ) means the Canada Revenue Agency;(v ) means Computershare Trust Company of Canada;(w ) means the director appointed pursuant to Section 260 of the CBCA;(x ) has the meaning ascribed thereto in Section 5.1;(y ) means the [COMPANY] Shares held by Dissenting Shareholders in respect of which suchDissenting Shareholders have given Notice of Dissent;(z ) means a registered holder of [COMPANY] Shares who has duly and validly exercisedthe Dissent Rights in respect of the Arrangement Resolution in strict compliance with the Dissent Rights andwho has not withdrawn or been deemed to have withdrawn such exercise of Dissent Rights;(aa ) shall have the meaning ascribed thereto in subsection 3.1(a)(xvi)G hereof;(bb ) means the date upon which the Arrangement becomes effective as established by the dateof issue shown on the certificate giving effect to the Arrangement as issued by the Director pursuant toSection 192(7 ) of the CBCA ; ( cc ) means 12:01 a.m. ( Vancouver time ) on the Effective Date or such other time as Cardiomeand Cipher may agree upon in writing;(dd ) means a ratio of one ( 1 ) [COMPANY] Share for each one ( 1 ) [COMPANY] Share ; providedhowever, that the [COMPANY] Board may by resolution determine to adjust and set the number of CardiomeShares in such ratio at any number between one ( 1 ) and ten ( 10 ) so as to permit compliance with anyapplicable stock exchange requirements;(ee ) with reference to:(i)a [COMPANY] Share means the amount that is the closing price of the [COMPANY] Shares onthe TSX on the last trading day immediately prior to the Effective Date;(ii)a [COMPANY] Share means the amount that is the Fair Market Value of a [COMPANY] Sharemultiplied by the Exchange Ratio;(ff ) means the order of the Court granted pursuant to Section 192 of the CBCA, in a formacceptable to the Parties, each acting reasonably, approving the Arrangement, after a hearing upon theprocedural and substantive fairness of the terms and conditions of the Arrangement, as such order may beaffirmed, amended, modified, supplemented or varied by the Court ( with the consent of the Parties, eachacting reasonably ) at any time prior to the Effective Date or, if appealed, as affirmed or amended ( provided, however, that any such amendment is acceptable to the Parties, each acting reasonably ) on appeal unlesssuch appeal is withdrawn, abandoned or denied;(gg ) means the holders of [COMPANY] Shares immediately prior to the EffectiveTime;(hh ) ( i ) any multinational or supranational body or organization, nation, government, state, province, country, territory, municipality, quasi - government, administrative, judicial or regulatory authority, agency, board, body, bureau, commission, instrumentality, court or tribunal or any political subdivisionthereof, or any central bank ( or similar monetary or regulatory authority ) thereof, any taxing authority, anyministry or department or agency of any of the foregoing, ( ii ) any self - regulatory organization or stockexchange, including the Toronto Stock Exchange, ( iii ) any entity exercising executive, legislative, judicial, regulatory or administrative functions of or pertaining to government ; and ( iv ) any corporation or other entityowned or controlled, through stock or capital ownership or otherwise, by any of such entities or other bodiespursuant to the foregoing;(ii ), when used with reference to any securities of [COMPANY], means the holder of such securities shownfrom time to time in the securities register maintained by or on behalf of [COMPANY] in respect of suchsecurities;(jj ) means $ 1.00;(kk ) in respect of a stock option means the amount, if any, by which the aggregate FairMarket Value at that time of the securities subject to the option exceeds the aggregate exercise price of theoption;(ll ) means the interim order of the Court to be issued following the application thereforcontemplated by Section 2.3(b ) of the Arrangement Agreement, after being informed of the intention to relyupon the exemption from registration under Section 3(a)(10 ) of the U.S. Securities Act with respect to theCorrevio Shares and [COMPANY] Replacement Options issued pursuant to the Arrangement, in a form acceptableto the Parties, each acting reasonably, providing for, among other things, the calling and holding of theCardiome Meeting, as such order may be affirmed, amended, modified, supplemented or varied by the Courtwith the consent of the Parties, each acting reasonably ; ( mm ) means a notice of dissent duly and validly given by a registered holder of CardiomeShares exercising Dissent Rights as contemplated in the Interim Order and as described in Article 4;(nn ) means, at any time, options to acquire [COMPANY] Shares granted under the Stock Option Plan whichare, at such time, outstanding and unexercised ( whether or not vested);(oo ) means a holder of one or more Options;(pp ) means, collectively, [COMPANY], [COMPANY] and Cipher and means any one of them;(qq ) means this plan of arrangement and any amendments or variations hereto made fromtime to time in accordance with the terms hereof, the Arrangement Agreement or made at the direction of theCourt in the Final Order, with the consent of the Parties, each acting reasonably;(rr ) means a non - interest bearing demand promissory note to be issued by [COMPANY] in favourof [COMPANY] with a principal amount equal to the excess of the fair market value of all of the assets ofCardiome, less the fair market value of the Retained Assets, over the fair market value of all of the liabilitiesand obligations of [COMPANY] of any kind or nature, less the fair market value of the Retained Liabilities;(ss ) means [COMPANY] ’s 2014 Phantom Share Unit Plan adopted with effect from December 6, 2014;(tt ) means, as of any date, phantom share units issued under the PSU Plan outstanding as of such date;(uu ) means [COMPANY] ’s Amended Restricted Share Unit Plan adopted with effect from May 9, 2014;(vv ) means, as of any date, restricted share units issued under the RSU Plan outstanding as of such date;(ww ) means a holder of one or more [COMPANY] Shares;(xx ) means an amount equal to $ 25,500,000 to be paid by Cipher to [COMPANY] inpayment for all [COMPANY] Shares held by [COMPANY] pursuant to the terms of the Arrangement;(yy ) means the Incentive Stock Option Plan of [COMPANY] last approved by Shareholders onJune 20, 2017;(zz ) means the Income Tax Act ( Canada ) including all regulations thereunder;(aaa ) means the United States Securities Act of 1933, as amended and the rules andregulations promulgated thereunder ; and(bbb ) means the United States Internal Revenue Code of 1986, as amended;(ccc ) means a holder of one or more Warrants ; and(ddd ) means, at any time, purchase warrants to acquire [COMPANY] Shares which are, at such time, outstanding and unexercised ; Any capitalized terms used but not defined herein shall have the meaning ascribed to such terms in the ArrangementAgreement . In addition, words and phrases used herein and defined in the CBCA and not otherwise defined herein orin the Arrangement Agreement shall have the same meaning herein as in the CBCA unless the context otherwiserequires