definiens: means any and all Know - How ( A ) existing as of the Effective Date that ( i ) wascreated, conceived or developed by ( 1 ) the Principal Investigator ; ( 2 ) by UHN employees oragents under the direction or supervision of the Principal Investigator, or ( 3 ) the UHN CRO ; ( ii ) isowned or controlled by UHN and ( iii ) is listed or otherwise defined in Schedule, or Schedule, or ( B ) existing as of the Effective Date or during the Term that was ( i ) created, conceived ordeveloped by one or more third party(ies ) in collaboration with UHN or the Principal Investigator ( orUHN employees or agents of UHN under the direction or supervision of the Principal Investigator)in connection with the UHN Planned Trial and for which UHN has been granted exclusive rightspursuant to a Fabry Trial Team Agreement . In the event that there exists as of the Effective Dateother Know - How which is ( a ) relevant to the Field of Use, ( b ) created, conceived or developed by(1 ) the Principal Investigator, ( 2 ) by UHN employees or agents under the direction or supervisionof the Principal Investigator, or ( 3 ) the UHN CRO, and ( c ) owned or controlled by UHN and is notImproved Therapies Know - How, the Parties will update Schedule A and/or Schedule Baccordingly . For greater certainty Fabry Know - How does not include Fabry Patents, ImprovedTherapies Patents or Improvement Patents or any Patent Rights in the SRA Intellectual Property