definiens: means any Neoepitope Prediction Algorithms and any other Know - How, in each case, that iseither ( a ) both ( i ) Controlled by [COMPANY] as of the Execution Date or at any time thereafter until the end of the Term ; and ( ii ) necessary or usefulto research, develop, commercialize, make, have made, use, offer for sale, sell and import Pharmaceutical Products that comprise ( A ) oneor more Neoepitope RNA(s ), but not any Non - Neoepitope RNA(s ) or ( B ) one or more Permitted Hybrid Neoepitope RNA(s ), but not anyNon - Neoepitope RNA(s ) or ( b ) Controlled by Roche as of the Effective Date or during the Term and used or disclosed to [COMPANY] in theperformance of the Research Plan, GDP or CMC Development Plan ; provided, however, that [COMPANY] Know - How specifically excludesCollaboration Know - How