definiens: , with correlative meanings or to, means covalent chemical bonding of any poly ( ethylene glycol ) reag ent ( including the REAGENT and including covalent chemical bonding through linking groups ) with or to another material or materials . Such materials incl ude, without limitation, proteins, peptides, oligonucleo tides, other biomolecules, small molecules, therape utic agents ( including the THERAPEUTIC AGENT ), diagnostic agent s, imaging agents and detectable labels . Additional materials that may be PEGYLATED include without lim itation, polymers, liposomes, films, chemical separ ation and purification surfaces, solid supports, metal / me tal oxide surfaces and other surfaces such as, by w ay of example but not limitation, those on implanted devi ces, and equipment, where a poly ( ethylene glycol ) reagent ( including the REAGENT ) is covalently chemically bo nded to one or more reactive molecules on the surfa ce of such device or equipment . shall includ e the synthesis, derivatization, characterization, and modification of PEG for such purposes, together wit h the synthesis, derivatization, characterization, and modification of the raw materials and intermediates for the manufacture of poly ( ethylene glycol ) reag ents ( including the REAGENT ) or products ( including the PRODUCT ) incorporating such poly ( ethylene glycol ) reagent by means of covalent chemical bonding, and all methods of making and using each and all of the foregoing