definiens: means, with respect to a particular item and a particular Patent, that such Patent claims or covers, in any of the countries of manufacture, use, and/or sale, ( a ) the composition of such item, of any of its ingredients or formul ations, or of any product containing such item or that is made using such item by virtue of such product containing or being made using such item ; ( b ) a method of making or using any of the foregoing things referred to in ( a ) ; ( c ) an item used or present i n the manufacture of any of the foregoing things referred to in ( a ) or ( b ) ( for example, with respect to a biologic, any vector, plasmid or cell line used to manufacture such product or item or any ingredient in either of them ) ; or ( d ) any method by which the foregoing things referred to in ( a ), ( b ), or ( c ) was discovered or identified, in the absence of a license or assignment, infringe a valid claim of such Patent