definiens: shall mean the amount A divided by B ( NB ) where A is the sum of ( i ) the product of the aggregate Net Sales ofa Collaboration Product up to and including [ $ 500 million ] in a calendar year multiplied by [ 1 O%],plus ( ii ) the product of the incremental aggregate Net Sales of the Collaboration Product over [ $ 500 million ] up to and including [ $ 1.000 million ] in a calendar year multiplied by [ l2 % ], plus ( iii ) the product of the incremental aggregate Net Sales of the Collaboration Product over [ $ l, OOOmiIIion ] up to and including [ $ 1,500 million ] in a calendar year multiplied by [ 14 % ], plus ( iv ) the product of the incremental aggregate Net Sales of the Collaboration Product over [ $ 1,500 million ] in a calendar year multiplied by [ 16 % ], and B is the aggregate Net Sales of the Collaboration Product in a calendar year