definiens: means with respect to EPIZYME or CELGENE, as applicable, such efforts thatare consistent with the efforts and resources then used by EPIZYME or PARENT, as applicable, in the exercise of itscommercially reasonable practices relating to the research, Development ( including seeking Regulatory Approval),Manufacture and Commercialization of a pharmaceutical product at a similar stage in its research, Development orcommercial product life as the relevant Compound ( including Licensed Compound ) or Licensed Product, and that hascommercial and market potential similar to the relevant Compound ( including Licensed Compound ) or Licensed Product, taking into account issues of intellectual property scope, subject matter and coverage, safety and efficacy, product profile, competitiveness of the marketplace, proprietary position, regulatory exclusivity, anticipated or approved labeling, present andfuture market potential, and profitability ( including pricing and reimbursement status achieved or likely to be achieved )