definiens: sha ll mean any compound which is the subject of a PATENT owned or controlled by ADOLOR at any time up to the fifth ( 5 / th/ ) anniversary of the EFFECTIVE DATE which is a peripherally selective mu opiate receptor agonist without -3- significant central nervous system effects, or a prodrug or metabolite thereof, or a peripherally selective mu opiate receptor agonist compound which inhibits the production or function of Tumor Necrosis Factor ( TNF ) or other cytokines, or prodrug or metabolite thereof . Examples of such compounds include, without limitation, loperamide, diphenoxin, diphenoxylate, desmethyl -loperamide and loperamide N -oxide and all esters, salts, hydrates, solvates, polymorphs and isomers thereof which are structurally related to the compounds disclosed in the PATENTS . A ' peripherally selective mu opiate receptor agonist ' as used in this paragraph means any mu opiate receptor agonist compound that has a selectivity ratio of at least 30 fold ( expressed as Ki ratio ) for the human mu opioid receptor versus human delta or kappa opiod receptors in standard opioid receptor binding assays such as the Chinese Hamster Ovary ( CHO ), cloned human opioid receptor binding assay, and is equal to or greater than diphenoxylate in peripheral selectivity