definiens: means any invention, discovery, development or mo dification with respect to PB2452 or the Product or relating to the development, manufac ture, use or commercialization of PB2452 or the Pro duct, whether or not patented or patentable, CONFIDENTIAL including any enhancement in the efficiency, operat ion, manufacture, ingredients, preparation, present ation, formulation, means of delivery or dosage of PB2452 or the Product, any discovery or development of any new or expanded methods of treatment, use or indications f or PB2452 or the Product or any discovery or develo pment that improves the stability, safety or efficacy of PB2452 or the Product ; in each case that is conceiv ed, discovered, developed or otherwise made by or on behalf of BioV ectra, whether solely or jointly with [COMPANY], und er or in connection with this Agreement or the performance o f [COMPANY] ’s obligations hereunder