definiens: shall mean the manufacture of one or more of the Program Vaccines through the use of the particular combination of Program Inventions and Background Technology as implemented by Children 's and TGC under this Agreement during and in the course of the Research and Development Program ( as the same may be supplemented or improved by or for IA VI with other inventions or technology from sources other than Children 's or TGC ), solely for distribution in the Public Sector, and the use, sale, offer for sale, and import of such Program Vaccines so manufactured in and to the Public Sector . IA VI understands that Children 's and/or TGC may also engage, outside the Research and Development Program but contemporaneously with it, in other activities, programs or collaborations using and/or improving upon the Background Technology or other technology that may be useful in connection with one or more vaccines, and that Children 's and/or TGC may continue, after the end of the Research and Development Program, to improve the Background Technology and to make other inventions or to develop other know - how which may be useful in connection with one or more vaccines, including without limitation by improving concentration levels, purity, scale of manufacture, efficiency of manufacture, clinical effectiveness, safety, and/or quality of the results . Unless otherwise agreed by Children 's or TGC, in its discretion and as applicable to it respectively, under subsequent agreement(s ), the Program Field will not include the use or exploitation of any such improvements, inventions or know - how so developed or obtained by or for Children 's or TGC outside or after the Research and Development Program