definiens: shall mean the Know - how owned by, or controlled b y ( including Know - how exclusively licensed to Recepto s from TSRI ), [COMPANY] and existing as of the Amendment Date or arising from the performan ce by [COMPANY] of the Program which is necessary or useful for the functions of Protein Ex pression, Crystallization Studies, * * * selection, GPCR structure determination in the cour se of generating a Solution, all with respect to a Tech Transfer Target, including ( i ) expression systems for GPCR cDNA constructs related to a Tech Transfer Target, and processes for their design and generation, ( ii ) methods for developing conditions suitable for preparation and harvesting of diffraction quality crystals of such expressed protein, ( iii ) methods for biophysic al ligand screening using GPCR protein, ( iv ) methods for x - ray diffraction data collection, crystallographic computations, three - dimensional model building and refinement in connec tion with the generation of a structure for such Tech Transfer Targets, ( v ) a suitable * * * for the Training Tech Transfer Targets, and ( vi ) Solution for the Training Tech Transfer Target s. For clarity, 2 * * * Confidential material redacted and filed separa tely with the Commission