definiens: means all Patents ( including all claims and the entire scope of claims therein)Controlled by Isis or its Affiliates on the Effective Date and/or at any time through the period ending on the [ * * * ] yearanniversary of the expiration of the Research Term, in each case claiming inventions specifically directed to anyCompounds or Products, including but not limited to patents and patent applications specifically claiming suchCompounds or Products, methods of using such Compounds or Products, methods and materials specific to thesynthesis of such Compounds or Products, and methods and materials specific to formulating and administering suchCompounds or Products ( including by way of example and without limitation, such Patents claiming ( a ) the sequenceor a portion thereof corresponding to the PCSK9 gene sequence or a portion thereof, ( b ) the specific composition ofmatter of a Product, ( c ) methods of using a Product as a therapeutic or ( d ) methods of using a Compound as atherapeutic ) ; provided however, that ( x ) for any such Patents that include Pass Through Obligations, the provisions ofSection 5.5 will govern whether such Patent will be included as an Product Specific Patent Right and ( y ) unless theParties otherwise agree in writing, Patents that include claims that are directed to subject matter and have a scopethat is applicable to ASOs in general, and not specifically directed to a Compound or Product, shall be considered tobe Isis Core Technology Patents ( or Isis Manufacturing Patents, as applicable )