definiens: means, with respect to the Product, commercially reasonable efforts of a Person to carryout its obligations in a diligent manner using such efforts and employing such resources as are normally used by such Personin the exercise of its reasonable business discretion relating to the research, development or commercialization of a product, that is of similar market potential at a similar stage in its development or product life, taking into account issues of marketexclusivity ( including patent coverage, regulatory and other exclusivity ), safety and efficacy, product profile, thecompetitiveness of alternate products in the marketplace or under development ( other than any such product owned orlicensed by a Selling Entity ), the launch or sales of a generic or biosimilar product, the regulatory structure involved, and theprofitability of the applicable product ( including pricing and reimbursement status ), and other relevant factors, includingtechnical, commercial, legal, scientific, and/or medical factors