definiens: means any change affecting, or condition -------------------------------having an effect on, the Company or any Company Subsidiary that is, or wouldreasonably be expected to be, materially adverse to the business, financialcondition or results of operations of the Company and the Company Subsidiaries, taken as a whole, except, in each case, for any such change or conditionresulting from or arising out of ( i ) changes or developments in thebiotechnology industry generally, which changes or developments do notdisproportionately affect the Company relative to other participants in thebiotechnology industry in any material respect, ( ii ) changes or developments infinancial or securities markets or the economy in general which changes do notdisproportionately affect the Company in any material respect, ( iii ) any changein the Company 's stock price or trading volume, in and of itself or ( iv ) theannouncement of the transactions contemplated by this Agreement