definiens: shall mean any change, event, circumstances ordevelopment that, individually or in the aggregate, has had, or is reasonablylikely to have, a material -47-<PAGE > THE SYMBOL ' * * ' IS USED THROUGHOUT THIS EXHIBIT TO INDICATE THAT A PORTION OF THE EXHIBIT HAS BEEN OMITTED AS CONFIDENTIAL.file:///C|/Users / BSAlaptop / Desktop / New%20EDGAR%20Transit / Angiotech_AmerMedicalInstruments_0106_Acq.txt [ 12/26/2016 7:19:22 AM]adverse effect on the financial condition, properties, assets, liabilities, business, results of operations of the Company and its Subsidiaries taken as awhole, other than ( i ) any change in the economy or financial markets generallyin the United States ; ( ii ) any change generally affecting the industries inwhich the Company and its Subsidiaries operate, except to the extent the Companyand its Subsidiaries are disproportionately affected as compared to othersimilar companies in such industries ; or ( iii ) any change in Law or GAAP