definiens: means, subject to Section 4.1.6, ( A ) all Patents Controlled by Regulus on theEffective Date and listed on Appendix 4, and ( B ) all Patents Controlled by Regulus during the IP Period that claim(a ) microRNA Compounds in general, ( b ) chemistry or delivery technology useful technology useful in connection withmicroRNA Compounds, ( c ) general mechanisms of action by which a microRNA Compound modulates microRNAs, or(d ) general methods of treating or preventing an Indication by modulating one or more microRNAs ; provided, however, thatin each case, Regulus Platform Technology Patents do not include ( 1 ) any Patents Controlled by Regulus or its Affiliates tothe extent that such Patents claim ( a ) the sequence or a portion thereof corresponding to a specific microRNA sequence or aportion thereof, ( b ) the specific composition of matter of any microRNA Compound, ( c ) methods of using as a therapeutic anymicroRNA Compound ; ( 2 ) the Tuschl 3 Patents ; and ( 3 ) the Rockefeller Patents