definiens: means any change affecting, ------------------------------or condition having an effect on, Parent, Merger Sub or any of Parent'sSubsidiaries that is, or would reasonably be expected to be, materially adverseto the business, financial condition or results of operations of Parent and itsSubsidiaries, taken as a whole, except, in each case, for any such change orcondition resulting from or arising out of ( i ) changes or developments in thebiotechnology industry generally, which changes or developments do notdisproportionately affect Parent relative to other participants in thebiotechnology industry in any material respect, ( ii ) changes or developments infinancial or securities markets or the economy in general which changes do notdisproportionately affect Parent in any material respect, ( iii ) any change inParent 's stock price or trading volume, in and of itself or ( iv ) theannouncement of the transactions contemplated by this Agreement