definiens: means an oligonucleotide that binds directly to DNA or RNA within a cell on a selectivebasis determined by the nucleotide sequence of the target DNA or RNA and exerts its biological activitypredominantly through binding to DNA or RNA to inhibit the transcription or replication of the target DNA or RNA orbinding to RNA to inhibit the translation, processing, packaging or regulatory activity of the target RNA . A CodeblockerCompound may also have a mechanism of action or biological activity other than one conferred through direct bindingto RNA or DNA provided that ( i ) the compound originally was designed to bind a target DNA or RNA and ( ii ) the finalcompound or any compounds used to derive the final compound were not identified using62 Execution Copyselective purification and polymerase amplification in any fashion . An oligonucleotide, is [ * * ] . An oligonucleotideincludes RNA or DNA fragments, and may be composed of naturally occurring or non - naturally occurring bases, sugars or intersugar linkages . An oligonucleotide may have [ * * ] . Oligonucleotides may be made such that adjacentnucleoside or nucleoside fragments are linked together by [ * * ] linkages to form the [ * * ] in the linkage