definiens: , as use~ herein, shall mean patent rights to any subject maner claimed in or cov~ ed by eithcr or both of the following : ( a ) U.S. Patent Applic~ on Serial No . 421,096 entitled which is assiilled to the licensor and was fil d by Drs . Dennis Siamon and Manin Cline on October 12, 1989, I C Case No . 82 - 215 - R ) which is a reissue application of U.S .. atent Nwnber 4,699,877 entitled, assigned to the licensor and tiled by Drs . 0, 's Siamon and Maron Cline on November 20, 1984 ( UC Case If . 82 - 215 - 3 ) which is a continuation - in - pan application of U.S. f tent Application No . 496.027, tiled on May 19, 1983 ( 82 - 215 - 2 ) ( bandoned ), which is I continuation - in - pan application of U.S Patent Application No . 439.252, filed on November 4, 1982 (: C Case No . 12 - 215 - 1 ) ( abandoned ) ; Determination of StaNS In Neoplastic Disease " which is as ~ i ned jointly to the Licensor . the University of Texas at San Anton~ and Genentech . Inc, and was filed by Drs, DeMis Slamon, Will ~ McGuire and Axel Ullrich ( respectively ) on December 31, 1986 ( UC Case No, 86 - 243 ) and any reissues, reexaminations and c ' ections thereof, to the extent that such patent riihts are owned by t!\ Licensor as at least a co - assignee ; and continuina applicatid and continuations - in - part applications thereof, includina divisions, sub, tutions, any patents or reissues issuing on said patents, applications, c tinuina applications and continuations - in - part, and any correspondina r. reian applications or patents and any reissue, reexamination or correct ( ns of any of the foregoing