definiens: has the meaning set out in Clause 12.8 ; has the meaning set out in Clause 12.8 ; University College London, an institution incorporated in the United Kingdom by Royal Charter and having its address at Gower Street, London, WC1E 6BT ; means ( i ) the Know -How listed in Part A of Schedule 3 ; and ( ii ) excluding Program IP, Program Know -How, Manufacturing Know -How, the [ * * ] and Know -How relating to the use of HLP1 Promoter Sequence in connection with any [ * * ] Product, all othe r Know -How generated by AN and/or the AN Laboratory and/or used by AN and/or the AN Laboratory pursuant to or in conjunction with any of the Programs ( or any combination of, or across any of, the Programs ) and which is Controlled by UCLB as of the Effectiv e Date, or in relation to the Second Serotype Option Program is Controlled by UCLB at any time during the period from the Effective Date until the date of exercise of the Second Serotype Option, or in relation to the Additional Programs is Controlled by UC LB at any time during the period prior to the Amendment Date ; and ( iii ) any Patent Rights Controlled by UCLB from time to time in respect of any of the Know -How identified under ( i ) or ( ii ) above and/or the Background Materials ; has th e meaning set out in Clause 30.2 ; means a claim within ( i ) an issued or granted and unexpired Patent Right, including any Licensed Patent ; or ( ii ) a pending application for a Patent Right including an application with respect to any Licensed Patents, which has not been pending for more than [ * * ] from the date of the priority filing from which such pending application originates, and in each case of ( i ) and ( ii ) above, which has not been held unenforceable, unpatentable or invalid by a decisio n of a court or government body of competent jurisdiction, or where appealed within the time allowed for appeal has not been held unenforceable, unpatentable or invalid by an appellate body of competent jurisdiction ( including by the highest appellate court in the relevant jurisdiction where appealed to that court ), or, which has not been withdrawn, cancelled, revoked, disclaimed, or rendered unenforceable through disclaimer or otherwise, or which has not been donated or dedicated to the public . Surrendered or which has not been deemed invalid by an interference or opposition panel or court as part of any interference or opposition proceeding ; a period of twelve ( 12 ) months commencing on 1 January ; 1.2 In this Agreement, unless the context require s otherwise : 1.2.1 use of the singular includes the plural and vice versa and use of any gender includes the other genders ; 1.2.2 any reference to is a reference to this Agreement as from time to time amended, varied or extended in any way ; and, 22 Certain confidential information contained in this document, marked by [ * * ], has been omitted because the information ( i ) is not material and ( i i ) would likely cause competitive harm to the Company if publicly disclosed