definiens: means, with respect to particular obligations or tasks, such level ofefforts applied to carry out such obligations or tasks consistent with the efforts used in thebiopharmaceutical industry by a company of comparable size in connection with the development orcommercialization of biopharmaceutical products that are of similar status, to accomplish such obligationsor tasks, at the same stage of development or commercialization, as applicable, for internally developedhealthcare products in a similar area with similar market potential, at a similar stage of their product lifetaking into account the existence of third party ( not Licensee ’s own ) competitive products in the marketplace or under development, the proprietary position of the product, the regulatory structure involved, theanticipated profitability of the product and other commercially - relevant factors . It is understood that suchfactors may change from time to time based upon changing scientific, business and marketing and returnon investment considerations and that the level of efforts typically devoted by Licensee may also change, based on such changes and/or changes in development or commercial stage