definiens: means an Antibody with respect to which [COMPANY] has either significant marketing rights or has done significant · development ( e.g., created, humanized or conducted preclinical or clinical development ), the manufacture, import, use, offer to sell or sale of which would, ifnot licensed under this Agreement, infringe one or more claims in any PDL Licensed Patent, or infringe any component of the PDL Licensed Patents ( including supplementary protection certificates or applications therefor ), which have neither expired nor been disclaimed . ONE agrees and stipulates, for the avoidance of doubt, that trastuzumab ( Herceptin ), bevacizumab ( Avastin ), omalizumab ( Xolair ), ranibizumab ( Lucentis ), pertuzumab ( Perjeta ), and ado ~ trastuzumab emtansine ( Kadcyla ) are [COMPANY] Licensed Products