definiens: means, with respect to the research, Development, Manufacture orcommercialisation of a Compound or Licensed Product, as the case may be, efforts and resources commonly used inthe research- based pharmaceutical industry for compounds or products with similar commercial and scientificpotential at a similar stage in their lifecycle . Commercially Reasonable Efforts after First Regulatory Approval Filingshall be determined on a market - by- 3 market basis for each Compound and each Licensed Product, as applicable, provided that it is understood thatCommercially Reasonable Efforts with respect to commercialisation require the Party responsible forcommercialisation of a Compound or Licensed Product under this Agreement to apply for Health RegistrationApproval and Exploit Compound or Licensed Product at least in the Major Markets, unless commercialisation in aspecific Major Market is ( in itself ) commercially not viable and/or reduces the overall economic value of a Compoundor Licensed Product . Commercially Reasonable Efforts requires that a Party, at a minimum, assign responsibility forsuch obligations to qualified employees, set annual goals and objectives for carrying out such obligations, andallocate resources designed to meet such goals and objectives