definiens: means ( 1 ) licenses granted by Isis before or after the Effective Date to any Third Party underthe Isis Core Technology Patents, the Isis Manufacturing and Analytical Patents, or the Isis Manufacturing andAnalytical Know - How ( but not under the Isis Product - Specific Patents ) to ( a ) use oligonucleotides ( or supplyoligonucleotides to end users ) solely to conduct Research, or ( b ) enable such Third Party to manufacture or formulateoligonucleotides, where ( i ) such Third Party is primarily engaged in providing contract manufacturing or services and isnot primarily engaged in drug discovery, development or commercialization of therapeutics ; and ( ii ) Isis does notassist such Third Party to identify, discover or make an ASO designed to bind to an Exclusive Target ; and ( 2)material transfer, collaboration, or sponsored research agreements with academic collaborators or non - profitinstitutions solely to conduct non - commercial Research