definiens: means a chemical entity ( including any salt, fluorinated derivative, free acid, free base, clathrate, solvate, hydrate, hemihydrates, anhydride, ester, chelate, conformer, congener, crystal form, crystal habit, polymorph, amorphous solid, isomer, stereoisomer, enantiomer, racemate, prodrug, isotopic or radiolabeled equivalent, metabolite, conjugate, complex or mixture of such chemical entity, each a ) Developed or Controlled by Agios or any Affiliates identified as [ * * ], as of the date of its inclusionin a Program or thereafter found to have such activity ( whether or not during the Research Termor, in the case of any Related Compound, during or after the Research Term ) against a ProgramTarget, in the applicable direction of modulation, in the course of conducting a Program . For theavoidance of doubt, Compounds ( as defined in Appendix A or Appendix B ) shall be limited to ( a)the Program Compounds that the Parties reasonably agree at the time of Option exercise areActive against the applicable Program Target and are listed on Exhibit A to the applicableDevelopment & Commercialization Agreement, which, for the avoidance of doubt, shall includethe applicable Development Candidate and ( b ) such other Compounds ( as defined in AppendixA or Appendix B ) that are Active against the applicable Program Target