definiens: , with a correlative meaning or to, means the covalent chemical bonding of REAGENTS ( including without limitation covalent chemical bonding through linking groups ) with or to other materials, including, but not limited to proteins, peptides, oligonucleotides, biomolecules, small molecules, therapeutic agents ( including without limitation ACTIVE MOLECULES and the THERAPEUTIC AGENT ), diagnostiC agents, imaging agents, implanted devices, and equipment . shall include the CONFIDENTIAL Page 9 of 107 [ ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS J;'ILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OJ < ' THE SECURITIES ACT OF 1933, AS AMENDED . synthesis, derivatization, characterization, and modification of PEG for such purposes, together with the synthesis, derivatization, characterization, and modification of the raw materials and intermediates for the manufacture of REAGENTS, or products ( including without limitation the SELECTED PRODUCT ) incorporating such REAGENTS by means of [ covalent chemical bonding ] ( but excluding, in the case of PEGYLATED therapeutic agents ( including the SELECTED PRODUCT ), all [ physical components ] of such products other than [ the attached REAGENT ] and [ the chemical linkage ] by which such REAGENT [ is attached to such products ] ) . For clarity, PEGYLATION shall not include the attachment or association of REAGENTS with or to other materials by means [ other than covalent chemical bonding ]