definiens: means a collaboration involving the discovery and development of DoubleStranded RNA Products in which a Party plays an integral role in the experimentation and an important, though notnecessarily dominant or co - equal, role in the decision - making, relating to the discovery and development of Double StrandedRNA Products from the point in time at which the relevant Gene Target has been designated through the initiation of [ * * ] . ABona Fide Drug Discovery Collaboration may continue beyond the initiation of such [ * * ] . For Isis Products that are DoubleStranded RNA Products, a Bona Fide Drug Discovery Collaboration must be an Antisense Drug Discovery Program . For eachParty, collaborations that do not include or involve Patents licensed from the other Party hereunder shall not constitute BonaFide Drug Discovery Collaborations . A Party ’s experimentation relating to the discovery and development of DoubleStranded RNA Products that modulate a relevant Gene Target prior to the commencement of a collaboration shall be deemedto have been conducted in the course or the collaboration for purposes or determining whether the collaboration is a BonaFide Drug Discovery collaboration . A series of related collaborations and/or license agreements involving the discovery anddevelopment of Double Stranded90 RNA Products with the same sublicensee or related sublicensees that includes a Bona Fide Drug Discovery Collaborationagreement will be aggregated to constitute a single Bona Fide Drug Discovery Collaboration