definiens: means ( a ) the Materials Transfer Agreement, effective as ofMarch 8, 2013, by and between Tranzyme, Inc., Tranzyme Pharma Inc. and [COMPANY], as subsequently amended ( ) ; ( b ) the Collaboration and Option Agreement, effective as of April 2, 2013, by and between Tranzyme, Inc.,Tranzyme Pharma Inc., Hoffman - La Roche Inc. and Roche, as subsequently amended ( ) ; ( c ) the Non - Disclosure Agreement, effective as of June 5, 2012, by and betweenTranzyme, Inc., Tranzyme Pharma Inc. and [COMPANY] ; and ( d ) the Letter of Intent, dated November 6, 2013, by andbetween Ocera Therapeutics, Inc., Hoffman - La Roche Inc. and Roche ( )