definiens: shall mean the gross amount invoiced by Ligand, [COMPANY] or any affiliate or sublicensee of either Ligand or [COMPANY] to unrelated third parties for th e Product, Less : ( i ) trade, quantity and cash disco unts actually allowed ; ( ii ) discounts, refunds, rebates, chargeba cks, retroactive price adjustments and any other al lowances which effectively reduce the net selling price ; ( ii i ) actual product returns and allowances ; ( iv ) the manufacturing cost of drug delivery systems, including royalties payable thereon ; ( v ) any tax imposed on the product ion, sale, delivery or use of the Product ( excluding federal, state or local taxes based on income ) ; ( vi ) distrib ution expenses reasonably documented by Ligand ; and ( vii ) any othe r similar and customary deductions ( as defined and accepted by GAAP ), actually incurred . Such amounts shall be determined from the books and records of L igand, [COMPANY] and any affiliate or sublicense of either L igand or [COMPANY] which shall be maintained in accor dance with GAAP