definiens: means ( i ) United States Patent No . [ * * ] ( the ), together with anypatents issuing from any continuations, continuations - in - part ( to the extent that the claims therein are directed to subjectmatter disclosed in the ‘ [ * * ] Patent ), divisionals, substitutions, reissues, reexaminations or extensions of the ‘ [ * * ] Patent, and any foreign counterparts or equivalents of the foregoing, and ( ii ) the technical and regulatory information containedin the Manufacturing Technology Package, and ( iii ) any know - how owned or controlled by [COMPANY] MA ( with theright to grant licenses or sublicenses hereunder ) existing as of the effective date of the 2006 Supply Agreement that arenecessary or reasonably useful for the Manufacture of QS-21 and ( iv ) any Manufacturing Improvements owned orcontrolled by [COMPANY] MA or its Affiliates ( with the right to grant licenses or sublicenses hereunder ) whether or notclaimed by a patent filed by [COMPANY] MA