definiens: means all information and materials, including but not limited to, technology, experience, discoveries, impro vements, processes, formulae, data ( including but not limited to all preclin ical, clinical, toxicological, and pharmacological data ) and i nventions, trade secrets, patentable or otherwise, developed by UNIVERSI TY through Drs . Xxxxx and Shen, which on the Effective Date of this Agre ement are in UNIVERSITY 's possession and control, are not generally know n and are necessary or useful for LICENSEE in the research, 3 6 development, manufacture, marketing, use or sa le of compositions or methods for the attenuation of opioid tolerance and de pendence and the enhancement of opioid analgesic potency . Know - How shall al so include any Know - How and improvements or modifications to the Know - How which are developed by UNIVERSITY through Drs . Xxxxx, Xxxx and their staff after the Effective Date of this Agreement as a result of any rese arch funding provided by LICENSEE to UNIVERSITY pursuant to this Agreem ent