definiens: means : ( a ) where applied to carrying out specific tasks and obligations of a Party under this Agreement, expend ing reasonable, diligent, good faith efforts and re sources to accomplish such task or obligation as such Party ( o n its own and/or acting through any of its Affiliat es, sublicensees or subcontractors ) would normally use to accomplish a similar task or obligation under si milar circumstances ; and ( b ) where applied to Development, manufacture or Commercialization of a Licensed Pr oduct, the use of reasonable, diligent, good faith efforts and resources, in an active and ongoing program, a s normally used by such Party for a product discovered or iden tified internally by such Party, which product is a t a similar stage in its development or product life and is of similar market potential and similar in terms of pr ofitability ( without taking into account the effects of any pay ments to Miragen pursuant to this Agreement, except to the extent that such payments cause or may reasonably b e expected to cause the relevant Licensed Product t o be unprofitable or to have a negative net present valu e based on [COMPANY] ’s usual financial evaluations )