definiens: . Isis Intellectual Property Rights shall mean the claims that cover Mo tifs or RNaseH Dependent Mechanisms of Action of all patents and patent appl ications and any continuations or divisions thereof, whether now exi sting, now filed or later filed on inventions invented, licensed or sublicens ed by Isis prior to April 26, 2001, any patent issued with respect to any such pa tent applications, any reissue, reexamination, renewal or extension ( inclu ding any supplemental patent certificate ) of any such patent, any confirmation p atent or registration patent or patent of addition based on any such patent, and all foreign counterparts of any of the foregoing, which Isis owned or had the r ight to sublicense as of April 26, 2001, including without limitation the pa tents and patent applications set forth on EXHIBIT G hereto ; provided, however, t hat Isis Intellectual Property Rights shall not include manufacturing met hods, including without limitation reagents, synthons and processes used in manufacturing and analyzing oligonucleotides ; chemistries, including without li mitation modifications made to the backbone, sugar or base of an oligonucleotid e and oligonucleotide conjugates ( including the chemistries of the conjug ate and the conjugation methods ) ; formulations, including without limitatio n methods and reagents for delivery and uptake of oligonucleotides ; gene - relat ed patents, including without limitation patents to specific gene structures, gen e targets and treatments based upon a genetic target ; and patents and patent applications licensed to * Confidential Treatment Requested - 5 - < Page > Isis pursuant to the Non - Exclusive License Agreemen t dated March 19, 1999 between IDT and Isis