definiens: ( as defined in Section 4.1.1 of the Agreement ) or the Initiation of the first Phase II clinical trial ], as applicable and in accordance with paragraph 6 above, and each as required under the Development Plan for the Substitute Target program, then the discovery milestones under section 6.2 and the development milestones under section 6.3.1 of the Agreement shall be reduced in accordance with the column B of the chart below : ( 3 ) If a significant change of [COMPANY] 's corporate structure occurs [ after the Initiation of the first Phase II clinical trial, as applicable and in accordance with paragraph 6 above and prior to the ( as in defined Section 4.1.1 of the Agreement ) ] required under the Development Plan for the Substitute Target program, then the discovery milestones under section 6.2 and the development milestones under section 6.3.1 of the Agreement shall be reduced in accordance with the column C of the chart below : ( 4 ) If a significant change of AlTay 's corporate structure occurs [ after the completion of the first Phase II clinical trial ] required under the Development Plan for the Substitute Target program, or, if no such [ Phase II clinical trial ] is required in accordance with paragraph 6 above, after the completion of the first Phase I clinical trial, then the discovery milestones under section 6.2 and the development milestones under section 6.3.1 of the Agreement shall remain unchanged