definiens: means compositions, devices and methods for the prevention of infectionby HIV and other sexually transmitted pathogens, by topical, but not systemic, administration, utilizing cyanovirin - N, anti - HIV mutants of cyanovirin - N, including glycosylation - resistant mutants of cyanovirin - N, and anti - HIVfragments of both, including conjugated forms of cyanovirin - N, mutants of cyanovirin - N, and anti - HIV fragments ofboth, to increase the in vivo half - life, but excluding pegylated cyanovirin - N, pegylated mutants of cyanovirin - N, and pegylated anti - HIV fragments of both . For the avoidance of doubt, such compositions shall include sustainedrelease formulations ; devices shall include all drug delivery systems, including but not limited to condoms, sponges, vaginal rings, suppositories, IUDs and other solid matrices ; and topical administration shall include administrationto mucosal membranes, including vaginal, anal and oral membranes