definiens: means, where applied to carrying out specific tasksand obligations of a Party under this Agreement, expending commercially reasonable, diligent, good faith efforts and resources to accomplish such task or obligation as such Party ( on its ownand / or acting through any of its Affiliates, sublicensees or subcontractors ) would normally use toaccomplish a similar task or obligation under similar circumstances exercising reasonablebusiness judgment, it being understood and agreed that, with respect to [COMPANY] ’s obligationsin Section 6.04(a ) to the manufacture, development and commercialization of an RNAi Product, such efforts shall be substantially equivalent to those efforts and resources commonly used in thepharmaceutical or biotechnology industry by a similarly situated company of similar size andexperience in the exercise of its reasonable business discretion with respect to a product withsimilar characteristics at a similar stage in its development or product life, that is of similarcommercial potential, taking into account actual or potential issues including, but not limited to, issues relating to efficacy, safety, manufacturing, quality, supply, regulatory or market exclusivity, Patents and intellectual property protection, product profile, labelling, pricing, reimbursement, distribution, market potential, competitive conditions, the regulatory environment, and any othertechnical, legal, scientific, medical, operational or commercial factors that could reasonably beexpected to affect the profitability of such product by such Party in an active and ongoing programto manufacture, develop and commercialize a product owned by it or to which it has exclusiverights, which product is of similar economic potential as the RNAi Product, and at a similar stagein its development or product life as the RNAi Product