definiens: means any Know - How and Patents relating to the composition of matter, properties, use, or manufacture of Active Moieties, proteins, peptides, nucleotide - based molecules or small molecules whichKnow - How and Patents in each case ( a ) owned, licensed, or controlled by Naia or an Aﬃliate thereof and ( b ) in the case ofKnow - How, exists as of and/or was conceived prior to the Existing License Eﬀective Date, or is developed or obtained byNaia or an Aﬃliate thereof independently of the Agreement without the use of Amunix ’s Conﬁdential Information, and in thecase of Patents, claims or discloses inventions conceived prior to the Existing License Eﬀective Date or developed by Naiaindependently of the Agreement without the use of Amunix ’s Conﬁdential Information, or were obtained by Naiaindependently of the Agreement after the Existing License Eﬀective Date, and in each case all Intellectual Property relatedto such Know - How and Patents