definiens: sha ll mean the following compassionate use indications which, as of the Execution Date, are in cluded in one or more of [COMPANY] ’s active INDs f or the Compound : ( i ) Acute myocarditis of presumptive picornaviral origi n, ( ii ) Acute or progressive encephalitis of presumptive pi cornaviral origin, ( iii ) Neonatal sepsis of presumptive picornaviral origin, ( iv ) Evidence of presumptive picornaviral infection in t he presence of a primary or secondary immune deficient disorder ( e.g., Brutons X - linked agammagl obulinemia, severe combined immune deficiency, hyper IgM, hypogammaglobulinemia, common variable i mmune deficiency, bone marrow or organ transplant recipients ), and ( v ) VAPP, wild -type paralytic poliomyelitis, or other paralytic il lness of picornaviral origin