definiens: CIAS Trial " means a Phase IIa trial aimed at treating cognitive impairment associated with schizophrenia, which Phase IIa trial ( a ) tests multiple doses of Compound 3454, ( b ) is placebo - controlled and double - blinded, ( c ) requires dosing per patient based on a treatment plan with a period of a minimum of 8 weeks in duration, ( d ) includes a minimum of212 patients randomized ( 3 dose groups and 1 placebo group [ with a goal of having 160 patients reach a week 4 efficacy assessment ] ) or less than 212 patients if requested in writing by [COMPANY], ( e ) has as its primary goal an assessment of cognition based upon MATRICS, ( t ) uses secondary outcome measures in two areas : general psychopathology ( positive and negative symptoms of schizophrenia ; depression ) and social competence, and ( g ) includes smokers and non - smokers . [COMPANY] . shall have the right, in its sole discretion, to direct Memory in writing to terminate enrollment of new patients in the CIAS Trial at any point for any reason ; and Memory shall comply with such request as soon as reasonably possible . For the avoidance of · CONFIDENTIAL TREATMENT IS REQUESTED FOR INFORMATION IN BOLD AND BRACKETS doubt, it is understood and agreed that the actual achievement of [ the goal of having 160 patients reach a week 4 efficacy assessment ], as described in ( d ) above, is not required in order for such trial to constitute the ClAS Trial