definiens: means, with respect to the efforts to be expended by a Party with respect to any objective, those reason able, good faith efforts to accomplish such objecti ve as a biotechnology company would normally use to accompl ish a similar objective under similar circumstances . With respect to any efforts relating to the Development, the seeking or obtaining of Regulatory Approval or Commercialization of a Compound or Product by a Par ty, a Party will be deemed to have exercised Commer cially Reasonable Efforts if such Party has exercised thos e efforts normally used by a biotechnology company, in the relevant jurisdiction, with respect to a compound o r product of similar therapeutic modality, with sim ilar market potential in such jurisdiction and at a similar sta ge in its Development or product life cycle, as the Compound or Product, in each case, taking into account all rele vant factors that may affect the Development, Regul atory Approval, Manufacture or Commercialization of a pha rmaceutical product, including ( as applicable ): act ual and potential issues of safety, efficacy and/or stabili ty ; product profile ( including product modality, ca tegory and mechanism of action ) ; stage of Development or life cycle status ; actual and projected Development, Reg ulatory Approval, Manufacturing and Commercialization costs ; Manufacturing difficulties ; the likelihood of obt aining Regulatory Approvals ( including satisfactory reimbu rsement or pricing approvals ) ; the timing of such a pprovals ; the regulatory environment and the current and proj ected regulatory status ; labeling or anticipated la beling ; competitive landscape, existing or projected pricin g, sales, reimbursement and profitability, propriet ary position, strength and duration of patent protection and anti cipated exclusivity, and other relevant scientific, legal and commercial factors