definiens: means the sale, assignment, exclusive license or sublicense, transfer, divestiture or other disposition of all or substantially all of the Buyer 's right, title or interest in and to the Product, the Program or the Assets in the U.s . Teiritory ( or any geographic portion thereof or any broader territory that includes all or any portion of the U.S. Territory ) to a Third Party by the Buyer or its Affiliates, through one or more transactions, or any other transaction or series of transactions in which all or substantially all of the Buyer 's economic rights to the Product, the Program or the Assets in the U.S. Territory ( or any geographic portion thereof or any broader territory that includes all or any portion of the U.S. Territory ) is transferred to a Third - Party . For the avoidance of doubt, a Disposition Event shall include, without limitation, a sale, transfer, divestiture or other disposition to a Third Party of any of the equity interest in a Person that is an Affiliate of the Buyer and that holds any right, title or interest to all or substantially all of the Product, Program or Assets in the U.S. Territory ( or any geographic portion thereof or any broader territory that includes all or any portion of the U.S