definiens: means all patents and patent applications that are Controlled as of the Effective Date orthereafter during the Term by Rigel and/or its Affiliates and rights to which are reasonably necessary to Exploit theCompound(s ) or Product(s ) in the Field, including : ( i ) all substitutions, divisions, continuations, continuations - in - part thereof(to the extent directed to the subject matter disclosed in a patent or patent application described above ) and requests forcontinued examination of any of the foregoing, ( ii ) all patents issued from any of the foregoing patent applications, ( iii ) allreissues, renewals, registrations, confirmations, re - examinations, extensions, and supplementary protection certificates of anyof the foregoing, and ( iv ) all foreign equivalents of any of the foregoing . For clarity, the use of in this definitionshall exclude any Third Party that becomes an Affiliate due to such Third Party ’s acquisition of Rigel