definiens: shall mean, except to the extent published or otherwise generally known to the publicany technology, trade secrets, methods, processes, know - how, show - how, data, information, or results ( excepttechnology, trade secrets, methods, processes, know - how, show - how, data, information, or results solely related toIndependent SERM Inventions to the extent not published or otherwise generally known to the public ) that are(i ) developed by any one or more of the UT Contributors in the course of employment by UT or developed by any otherUT employee directly from his or her research or clinical investigation of SERMs utilizing any Proprietary SERMKnow - How ; and ( ii ) owned solely or in part by UTRF ( but, if owned in part by UTRF, only to the extent of the partowned by UTRF ) ; and ( iii ) necessary or reasonably useful for the practice of any of the Licensed Patent(s ), including(for purposes of explaining, and without expanding, the meaning of Sections 1.22 ( i ) through ( iii ) ) the chemopreventionof prostate cancer and any methods of which the primary purpose is to administer to a subject an effective dose of achemopreventive agent, toremifene, and analogs or metabolites thereof, to prevent recurrence of, suppress or inhibitprostate carcinogenesis