definiens: means a compound which is a chemical modification of a Lead Compound or other active structure disclosed by [COMPANY] to [COMPANY], having activity against the same Target a s such Lead Compound or other active structure, which ( i ) results from a chemical synthesis program based on Lead Compound or other active structure disclosed by Pha rmacopeia to [COMPANY], or ( ii ) is based on structure -function data relating thereto, or ( iii ) is based on Develop ed Technology . For clarification purposes it is und erstood that [COMPANY] can independently find compounds against th e Target from its own discovery activities . These compounds will not be designated as Derivative Comp ounds if [COMPANY], as shown by contemporaneous documentation, has developed these compounds indepe ndently of the intellectual property described in subsections ( i)-(iii ) above . Further, it is underst ood that Derivative Compounds with respect to a Tar get shall not include a compound if information about such compou nd 's activity against the Target already was in the public domain