definiens: shall mean the gross amount invoiced for the supply or sale of TRISENOX by Purchaser or itsAffiliates to unaffiliated third parties ( calculated in Dollars or, with respect to non - Dollar denominated sales, using the averageexchange rate in effect during the applicable period for non - Dollar denominated sales ), and less the following amounts to theextent deducted from or on such invoice or absorbed or accrued or reserved by Purchaser or its Affiliates in accordance withGAAP : ( i ) customary quantity, trade and/or cash discounts, chargebacks, anticipated returns, allowances, wholesaler inventorymanagement fees, rebates ( including any and all federal, state or local government rebates, e.g. Medicaid rebates ) and priceadjustments allowed or given ; and ( ii ) sales and other excise taxes and duties directly related to the sale, to the extent suchitems are included in the gross invoice price