definiens: shall mean, with respect toLicensee ’s efforts to accomplish a particular objective with respect to development and commercialization of a LicensedProduct under this Agreement, such reasonable and good faith efforts to accomplish a particular objective hereunder as areconsistent with the efforts biopharmaceutical companies ( defined below ) typically devote to compounds of similar marketpotential and at a similar stage of research or development as the Licensed Product, taking into account efficacy, safety, approved labeling, competitive products in the marketplace, the patent and other proprietary position of the Licensed Product, and other industry standard relevant factors . For purposes of this definition, means companiesin the biopharmaceutical industry of a size and stage of development similar to that of Licensee . Commercially ReasonableEfforts shall be determined on a market - by - market basis for a Licensed Product, and it is anticipated that the level of effortshall be different for different markets, and shall change over time, reflecting changes in the status of the Licensed Product andthe market(s ) involved . For purposes of clarity, Licensee ’s obligations to use Commercially Reasonable Efforts with respect toa Licensed Product under this Agreement allow for the delay, suspension or termination of efforts to develop or market anythe Licensed Product if, consistent with good medical or scientific judgment, Licensee determines that such delay, suspensionor termination is warranted based on any adverse condition or event relating to the safety or efficacy of the Licensed Product