definiens: means efforts and resources commonly used in the research - based pharmaceutical industry for a compound or product at a similar stage of research, development or commercialization, and having similar market potential . Commercially Reasonable Efforts shall be determined taking into account the stage of research, development or commercialization ofthe compound or product, the cost - effectiveness of efforts or resources while optimizing profitability, the competitiveness of alternative products that arc or are expected to be in the relevant marketplace, the proprietary position of the product, the regulatory and business environment, the likelihood of regulatory approval and product reimbursement, the profitability of the product, the existence of alternative products that may also be developed by the Parties, and all other relevant factors . Commercially Reasonable Efforts shall be determined on anindication - by - indication and market - by - market basis, and it is anticipated that the level of effort will change over time reflecting changes in the status 0 f the compound, product and the market involved