definiens: means any amendment to a Joint Plan or any work p lan or protocol under the Joint Exploratory Development Plan that ( a ) add s, deletes, discontinues ( except for discontinuance for a reason set forth below in clause ( f ) ) or materially changes a Clinical Study under such Joint Plan or the Joint Exploratory Development Plan or any other material Development activity under such Joint Plan or the J oint Exploratory Development Plan ; ( b ) materially alters the nature or scope of a Party ’s obligations under such Joint Plan or the Joint Exploratory Development Plan ; ( c ) changes the budget in such Joint Plan or the Joint Exploratory Development Plan by more than [ * * * ] per cent ( [ * * * ] % ) as compared to the budget last agreed on by the Parties mutually ; ( d ) materially changes any ti meline for performing any Clinical Study under such Joint Plan or the Joint Exploratory Development Plan or a ny other material Development activity under such J oint Plan or the Joint Exploratory Development Plan as c ompared to the timeline last agreed on by the Parti es mutually ; ( e ) could reasonably be expected to have a Material Adverse Effect ; or ( f ) could reasonably be expected to present a Safety Risk