definiens: means the costs incurred for or associated with any [ ... * * * ... ] and [ ... * * * ... ] or other [ ... * * * ... ] which are necessary for [ ... * * * ... ] contemplated by the Global Development Plan, in each case that aredirectly related to [ ... * * * ... ] for treatment of chronic HBV infection inhumans . In addition, Global Development Costs shall include [ ... * * * ... ] forthose activities that [ ... * * * ... ] of the Development of any Compound, including, [ ... * * * ... ] provided, that such allocations are mutually determined and agreedby the Joint Development Committee prior to such allocation in accordance withSection 2.2.4 of this Agreement . Global Development Costs shall not includecosts related to [ ... * * * ... ], including [ ... * * * ... ] of any [ ... * * * ... ] . GlobalDevelopment Costs include [ ... * * * ... ] including [ ... * * * ... ] and the [ ... * * * ... ] Study, and, in respect of studies or Development activities initiated prior tothe Option Period, all the costs incurred by the conduct of such studies orDevelopment activities after the date [COMPANY] exercises the Option