definiens: means all activities, whether i nitiated or conducted prior to or following receipt of Regulatory Approval and, if necessary, R eimbursement Approval ( both defined below ) for the Product in the Field in any jurisdiction, undertaken relati ng to the marketing, promoting, detailing, distribu ting, importing, exporting, selling and offering to sell the Product, including ( a ) import, export, distribu tion, offer for sale, sale, promotion and marketing, medical affair s, managed markets, conferences, and support of pat ient organizations, ( b ) to the extent necessary to sell such Product, regulatory activities, including the filing, obtaining and maintenance of Regulatory Filings, an d the filing, obtaining and maintenance of Reimburs ement Approval for the Product, filing of annual updates, payment of product and establishment fees, and ( c ) other similar activities directly relating to commerciali zation of the Product in the Field, whether such ac tivities are addressed in this Agreement or not . shall exclude Development activities, and when used as a verb, means to engage in Comme rcialization activities . For purposes of this Agree ment and for the avoidance of doubt, Commercialization e xcludes non - clinical manufacturing