definiens: shall mean the gross sales price actually charged by LEVPHARMA or an Affiliate, Subsidiary or Sublicensee in the Commercial Sale of C 1 Esterase Inhibitor for use in, less : ( a ) trade, prompt payment, quantity or cash discounts, rebates, and non - affiliated brokers ' or agents ' commissions, each as actually and customarily allowed and taken ; ( b ) amounts actually repaid or credited to customers on account of rejections or returns of specified products on which royalties have been paid hereunder to SANQUIN or on account of retroactive price reductions affecting such products ; ( c ) customary freight and other transportation costs, including insurance charges, and duties, tariffs, sales, use and excise taxes and other governmental charges based directly on sales, turnover Or delivery of the specified products and actually paid or allowed by LEVPHARMA or an Affiliate, Subsidiary or sublicensee of LEVPHARMA