definiens: means [ * * * ] % of the issued and outstan ding share capital of Atlantic ( on an as - issued, post financing basis ) . m eans all know how and Patents Controlled by Isis on the Effective Date and at any time durin g the term of the Agreement other than ( A ) Alicaforsen Patents, ( B ) ICAM-1 Specific Patents, ( C ) Isis Core Technology Patents, ( D ) Second Generation ICAM-1 Product - Specific Patents, ( E ) Isis Data, ( F ) Isis Manufacturing Know How, and ( G ) Second Generation Isis Data . For clarity, Excluded Isis IP include any know how and Patents Controlled by Isis which cover Isis ’ ( i ) formulation and delivery technology ( save as expressly claimed in the Alicaf orsen Patents, ICAM-1 Specific Patents, Second Generation ICAM-1 Product - Specific Patents a nd Isis Manufacturing Know How ), ( ii ) RNAi technologies, ( iii ) microRNA technologies, and ( iv ) chemical modifications and motifs other than Xxxx XXX Gapmer Chemistry, and ( v ) the Excluded Manufacturing IP