definiens: means : ( a ) monotherapy or in combination with other dyslipidemic therapies for treatment ofpatients with homozygous familial hypercholesterolemia ; ( b ) monotherapy or in combination with other dyslipidemictherapies for treatment of patients with severe hypercholesterolemia of any etiology unable to come within 15 % of NCEPLDL cholesterol goal on maximal tolerated oral therapy, as determined by the patient ’s prescribing physician;(c ) monotherapy or in combination with other dyslipidemic therapies for treatment of patients with severe combinedhyperlipidemia of any etiology unable to come within 15 % of NCEP non - HDL cholesterol goal on maximal toleratedoral therapy, as determined by the patient ’s prescribing physician ; and ( d ) monotherapy or in combination with otherdyslipidemic therapies for treatment of patients with severe hypertriglyceridemia unable to reduce TG<1000 on maximaltolerated therapy