definiens: shall mean with respect to a Party ’s obligations under this Agreement, including to Develop, Manufacture or Com mercialize the Product, those efforts and resources consistent with the usual practices of such Party i n pursuing the development or commercialization of its own pharmaceutical products that are of similar market potential and strategic value as such Product, taki ng into account all relevant factors including product labeling or anticipated labeling, present and future market pot ential, past performance of such product and such Party ’s other pharmaceutical products that are of similar market potential, financial return, medical and clinical consideratio ns, past and future regulatory environment and comp etitive market conditions, all measured by the facts and ci rcumstances at the time such efforts are due . Comme rcially Reasonable Efforts shall be determined on a country -by - country and indication - by - indication basis for the Product, and it is anticipated that the level of effort will change over time, reflecting changes in the status of the Products and the market(s ) or countries involved