definiens: means the effort, expertise and resources normall y [ * * * ] in the development or commercialization of a compar able pharmaceutical product controlled by [ * * * ] whi ch is of similar market potential at a similar stage of d evelopment or commercialization in light of issues of safety and efficacy, product profile, the competitiveness of t he marketplace, the proprietary position of the com pound, platform, or product, the regulatory structure invo lved, the profitability of the applicable products, product reimbursement and other relevant strategic and comm ercial factors normally considered [ * * * ] in making product portfolio decisions . For purposes of clarity . Comme rcially Reasonable Efforts will be determined on an 3 Indication - by - Indication ( if needed ) and country - by -country basis within the Territory, and it is anti cipated that the level of effort may be different for different Indications and countries and may change over time, reflecting changes in the status of the Licensed Product and t he Indications and country(ies ) involved