definiens: means, with respect to sales made by a Party or its Affiliates or Sublicensees, the aggregate gross amount invoiced by a Party or its Affiliates on all sales or transfer for consideration of any Collaboration Product in the Territory to a Third Party, less the following deductions, as determined in accordance with US GAAP ( generally accepted accounting principles as practiced in the United States of America ): 1.31.1 prevailing trade, quantity and cash discounts and similar adjustments for pharmaceutical companies under International Financial Reporting Standards ( IFRS ), including those granted on account of price adjustments, billing errors, rejected goods, damaged goods, returns, recalls, rebates, chargebacks, reimbursements or similar payments actually granted or given to patients, wholesalers or other distributors, buying groups, health care insurance carriers, managed care entities or other institutions, including any government - mandated rebates ; 1.31.2 reasonable freight, packing, shipping, postage and insurance charges ; and 1.31.3 customs or excise taxes required by Applicable Laws, including import duties, sales tax and other taxes ( except income taxes ) or duties relating to importation, use or sales of Collaboration Product