definiens: means:(a ) with respect to the Development of a particular Candidate Drug or the Commercialization of a particularProduct by [COMPANY], the efforts and resources typically used by [ * * * * * * * * ] in the development of productcandidates or the commercialization of products of comparable market potential, taking into account all relevantfactors ( including, as applicable and without limitation, stage of development, mechanism of action, efficacy andsafety relative to competitive products in development or in the marketplace, actual or anticipated RegulatoryAuthority approved labeling, the nature and extent of market exclusivity ( including patent coverage and regulatoryexclusivity ), cost of development and likelihood of obtaining Regulatory Approvals, actual or projected profitability(which may take into account, if and as applicable, pricing or reimbursement approvals or authorizations)(provided that in assessing such profitability the royalties, milestones or other payments due or potentially due toTargacept with respect to such Candidate Drug or Product pursuant to this Agreement shall not be taken intoaccount ), other products or product candidates ( including any [ * * * * * * * * ] ) that [COMPANY] is researching, developing or commercializing and availability of capacity to manufacture and supply for commercial sale);provided that [ * * * * * * * * ], the effect of diverting effort or resources to Developing [ * * * * * * * * ] on any product or productcandidate of [COMPANY] that is optimized to act through any Exclusivity Mechanism ( other than otherCandidate Drug(s ) or Product(s ) ) shall not be taken into account ; and 18(b ) with respect to the performance by [COMPANY] of the Research Program, any Additional ResearchProgram, any [COMPANY] Development Activities, an Option Compound Development Plan or its Manufacturing(as defined in Section 16.18(f ) ) obligations under Article 16 from time to time, the efforts and resources typicallyused by companies in the [ * * * * * * * * ] industry, with resources and expertise comparable to those of [COMPANY] ( orany successor thereto ) at such time, to perform such activities on their own behalf ( and not as a contractresearch organization ), provided that ( i ) in no event shall such efforts and resources be less than those typicallyused by companies in the [ * * * * * * * * ] industry with resources and expertise comparable to those of [COMPANY] [ * * * * * * * * ] and ( ii ) with respect to [COMPANY] ’s obligation to use Commercially Reasonable Efforts to conduct itsManufacturing obligations under Article 16, [COMPANY] ’s other obligations under the Research Program shall betaken into account