definiens: will be construed accordingly.6 1.54 . means, with respect to eﬀorts and resources to be expended by a Party to achievean agreed objective, such reasonable, diligent, and good faith eﬀorts and resources as such Party would normally use toaccomplish a similar objective under similar circumstances taking into account the responsible allocation of such Party’sresources under the circumstances, including, with respect to a Party ’s obligation to Develop or Commercialize a Product, those eﬀorts and resources consistent with the exercise of prudent scientiﬁc and business judgment as applied by anentity of similar size and resources to such Party to the Development or Commercialization ( as applicable ) of its ownproducts that are at a similar stage of Development or Commercialization and have similar market potential, taking intoaccount performance of other products, competitiveness of Third Party products, eﬃcacy, safety, patent and regulatoryexclusivity, anticipated or approved labelling, present and future market potential, competitive market conditions and theproﬁtability of the product in light of pricing and reimbursement issues . Commercially Reasonable Eﬀorts shall bedetermined on a market - by - market and Indication - by - Indication basis, and it is anticipated that the level of eﬀorts requiredmay be diﬀerent for diﬀerent markets and Indications and may change over time, reﬂecting changes in the status of theProduct and markets involved