definiens: means either : ( a ) [ * * * * * ] naturally occurring human protein encoded by a specific gene locus, as identified by the applicable transcript identifier ( i.e., [ * * * * * ] ), gene identifier ( i.e., [ * * * * * ] ), gene name and synonyms and DNA sequence coordinates, toget her with all variants of such protein, including the wild type, naturally occurring variants, engineered variants wherein modifications to the native amino acid sequence have been introduced ( for example, mutated versions, derivatives or fragments ), and sp ecies homologs, orthologs thereof, provided however that any such naturally occurring variant, engineered variant, or species homolog or ortholog possesses substantially similar biological activity to the naturally occurring human protein ( for example immu nogenicity in case of antigens ) ; or ( b ) [ * * * * * ] protein that is not covered by subclause ( a ) above, together with any variants, mutated versions, derivatives or fragments of such protein, provided that any such variant, mutated version, derivative or fragm ent [ * * * * * ] . If a given protein, e.g., an antibody comprises separated amino acid chains which might be delivered by separated mRNA Constructs such proteins would be defined as one Target