definiens: means any pharmaceutical or biologic product ( a ) that contains aCStone Checkpoint Antibody, or ( b ) with respect to which CStone or any of its Affiliatesexclusively Controls any Know - How or Patent Rights and that the Executive Officers ofeach Party agree in writing to include in a Blueprint / CStone Combination under thisAgreement pursuant to Section 5.5.2 ( Executive Officer Decision Regarding ProposedAdditional Blueprint / CStone Combinations ) and, with respect to any Active Ingredient inany ( i ) pharmaceutical product described in the foregoing clause ( b ), amorphous forms, crystalline forms, co - crystals, isomers, isotopic substitutions, pro - drug esters, metabolites, salts, hydrates, solvates, and polymorphs of such Active Ingredient, and ( ii)biologic product described in the foregoing clause ( b ), any-10- modifications, variants, fragments, or derivatives of such Active Ingredient, in each case(a ) and ( b ), in any form, presentation, formulation, or dosage form