definiens: means any of the following:(a ) a DNA - Binding Molecule that:(i ) Specifically Binds to a Type A Gene Target,(ii ) Specifically Binds to a Type B Gene Target and thereby causes the Correction of such Gene Targetat its native locus,(iii ) Specifically Binds to a sequence within a Safe Harbor Locus and thereby causes the insertion of afunctional copy of a Type B Gene Target ( or functional portion thereof ) at such Safe Harbor Locus ( without insertingany Gene other than the Type B Gene Target ), or(iv ) Specifically Binds to a Type C Gene Target, and in each case ( i ) – ( iv ) does not directly affect, in a manner that is preclinically or clinically significant ( asreasonably determined by Sangamo in the course of performing work pursuant to a Research and Development Planor pursuant to Section 2.12 ; which determination shall be reported to the JSC, based upon data that is shared with theJSC ), any Gene other than such Gene Target or Safe Harbor Locus, as applicable, to which such DNA - BindingMolecule Specifically Binds ; * * * CONFIDENTIAL PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION 3(b ) a molecule or vector that encodes a DNA - Binding Molecule described in(a ) but does not encode any other molecules that bind DNA;(c ) a cell arising from a CD34 + or other HSPC preparation, the DNA of which cell is modified ex vivo throughthe action of a DNA - Binding Molecule described in ( a ) of this Section 1.26 but not any other non - endogenous moleculethat binds DNA ; or(d ) a cell that is a descendent ( whether direct or indirect ) or a partially or fully differentiated form of a celldescribed in ( c ) of this Section 1.26 and does not contain any DNA modification or gene expression modificationresulting from the action of any non - endogenous molecule that binds DNA other than a DNA - Binding Moleculedescribed in ( a ) of this Section 1.26