definiens: means : the discovery, isolation, characterization, research, development, and/or commercialization of an Antibody useful for the diagnosis, treatment and/or prevention of one or more of the following disease conditions wherein the primary scientific rationale or activity is ~ neuronal and/or glial mechanisms of action or neuroprotection : rio neurodegenerative conditions including, without limitation, ( A ) Alzheimer 's disease, and ( B ) Parkinson 's disease but, in both instances, excluding the treatment and/or prevention of neurodegenerative conditions in humans associated with ! ) -amyloid deposition ( including, without limitation, Alzheimer 's disease and/or Mild Cognitive Impairment using either ( l ) immunological approaches directed at one or more epitopes of A ! ), or any naturally occurring variants thereof ( including, without limitation, the administration of an Antibody ), or ( 2 ) use of a beta secretase inhibitor ( including, without limitation, the administration of an Antibody ) ) ; 11 . diabetic neuropathy ; iii . pain, including, but not limited to, ( A ) post - operative pain, ( B ) chronic pain and ( C ) neuropathic pain, IV . spinal cord injury ; V. mUltiple sclerosis ; and/or VI . stroke, as a disease of the cerebrovasculature, provided, however, that for the purpose of this Agreement the term will not ] include the diagnosis, treatment and/or prevention of the above disease conditions caused by infectious pathogenic micro - organisms