definiens: means the oligonucleotide known as ISIS 678354 ( a lso known as IONIS - APOCIII - L Rx ) having the following sequence and chemistry : 5'-THA -AH P = O AG Me CMe UMe UMe CTTGT Me CMe CAG Me CMe UMe UMe UA Me U-3′. The underlined residues are 2'-O-(2 - methoxyet hyl ) nucleosides ( 2'-MOE nucleosides ) . The residues are arranged so that there are five 2'-MOE nucleosides at the 5 ' and 3 ' ends of the oligonucleotide flanking a gap o f ten 2'-deoxynucleosides . The cytosine and uracil bases are methylated at the 5 - position . Me U and T have the same structure and the choice for the symbol depends on whether the sugar is 2′-deoxy - D - ribose or D - ribose . The P = O designates the location of a phosphate diester lin kage . Each of the other internucleoside linkages is a phosphoroth ioate diester linkage . AH designates the location o f the aminohexyl linker and THA is 5 - N-{tris[(6-(2 - acetam ido-3,4,6 - tri - O - acetyl - β - D - galactopyranosyloxy)hexylamino)-3 - oxopropoxymethyl ] methyl}amino-5 - oxopentanoyl