definiens: shall mean the strategic plan appended to this Agreement as Appendix 1.57,which sets out the responsibilities of each Party for research and development leading to a Collaboration Product for each CollaborationTarget under the Agreement . On the Effective Date of this Agreement, a detailed Joint Research Plan in accordance with the conduct ofresearch described in Article 3 and the responsibilities of the JRC described in Article 6, shall be appended to Appendix 1.57 . Such JointResearch Plan shall detail the work to be conducted, the Lead Series Criteria, the Development Candidate Criteria, schedule, and level ofeffort in FTEs and budget for the initial Collaboration Target, and serve as exemplars for Joint Research Plans for each subsequentCollaboration Target approved by the JRC after the Effective Date, which shall be substantially similar in scope, responsibilities, deliverables, and resource requirements unless otherwise agreed in writing