definiens: means with respect to a Party, such efforts that are consistent with the efforts andresources normally used by * * * relating to the Research, Development and Commercialization of products ( a ) that havescientific attributes similar to those of the relevant Program DART or Licensed Product in oncology, ( b ) that are at a similarstage in their Research, Development, Commercialization or product life as the relevant Program DART or Licensed Product, and ( c ) that have commercial and market potential similar to the relevant Program DART or Licensed Product, taking intoaccount issues of intellectual property scope, subject matter and coverage, safety and efficacy, product profile, competitiveness with respect to Third Party products in the marketplace, proprietary position and profitability ( includingpricing and reimbursement status achieved or likely to be achieved ), and ( d ) solely owned by them or to which they haveexclusive rights . If either Party grants a sublicense to an Affiliate or Third Party as permitted under this Agreement, then, withrespect to such sublicensee Commercially Reasonable Efforts shall mean the efforts and resources ( as defined above in thisSection 1.13 ) normally used by the Party granting the sublicense, qualified by the items in clauses ( a ) – ( d ) inclusive