definiens: shall mean and include any individual, corporation, partnership, firm, joint venture, syndicate, association, trust, government body and any other form of entity or organization ; " Phase f ' shall mean that portion of the FDA submission and approval process which provides for the first introduction into humans of a Lead Compound and/or Licensed Product for the purpose of determining human toxicity, metabolism, absorption, elimination and other pharmacological action as more fully defined in 21 C.F.R. § 3 12.2 1 ( a ), and such equivalent regulations or standards of countries outside the United States as may be applicable to activities conducted hereunder ; shall mean a human e&¥1e that catalyzes the removal of a phosphate group from a protein and includes, without limitation, PTP - PEST and TC - PTIt shall mean all Patents and Know - How that are owned, controlled or licensed by either party or its Affiliates as at the Effective Date and/or become owned, controlled or licensed during the Term in connection with performance by either party under the Research Program and that relate to the research, development, utilization, manufacture or use of : ( i ) Compounds ( including Research Candidates, Prospective Lead Compounds, Additional Prospective Lead Compounds and Lead Compounds ) and Licensed Products that are directed against the Target ~ PTP - PEST, TC ~ PTP ( or any other Phosphatase ; and ( ii ) the Targets against which the Compounds or Licensed Products listed in clause ( i ) are directed ; ( bbb ) shall mean protein kinase B, an enzyme ; ( ccc ) shall mean the rate per year from time to time announced by the Royal Bank of Canada as the reference rate to determine interest payable on commercial loans to its most creditworthy customers ; ( ddd ) shall mean a Research Candidate proposed by Kinetek to QL T for consideration as a Lead Compound that has satisfied the general guidelines set out in the Research Plan to make the Research Candidate IND Ready ; [ ( eee ) [COMPANY] Know - How " shall mean all Know - How that becomes owned, controlled or licensed by [COMPANY] during the Term, and that : ( i ) arises in connection with the performance of the Research Program, or ( ii ) relates to : ( A ) all or any part of the Technology, or ( B ) any improvements to the Technology ; ' .~. ' . ... - : .... . .. ~''-'- ' . .. - { [ 27237 - 000IlS8020910.290 ] -7-(ggg ) shall mean any Patent that becomes owned, controlled or licensed by [COMPANY] during the,