definiens: means, for purposes of determining whether an Ind ication constitutes the first, second or third Indication, the following : ( A ) in the case of the Initial Field, ( 1 ) each of [ * ] and any other indication separately listed on Exhibit B ( but not those that may be designated as [ * ], as t he case may be ) ( ) will be treated as a distinct Indication and ( 2 ) any additional and [ * ] disease, disorder, or illness affecting [ * ] that is outside of the CNS Indications but in the Initial Field wil l be treated as a distinct Indication, provided that, for the purpose of this clause ( 2 ), [ * ] will be treated as the sam e Indication, and ( B ) in the case of the Expanded Field, ( 1 ) each of the Excluded Indications listed on Exhibit A ( but not those that may be designated as [ * ] ) will be treated as a distinct Indication and ( 2 ) any additional and [ * ] disease, disorder, or illness affecting [ * ] that is outside of the Excluded Indications will be treated as a di stinct Indication, provided that, for the purpose of this clause ( 2 ), [ * ] will be treated as the same Indication . For the purpose of determining whether a milestone event has been achi eved, the milestone event will not be deemed achiev ed unless the Distinct Indication [ * ]