definiens: shall mean the amount received by Spectrum, its Affiliates, its sublicensees or distributors on account of sales of a Product to Third Parties in the Territory, less the following deductions to the extent actually allowed or specif ically allocated to the Product by the selling part y using GAAP and not separately invoiced : ( i ) sales and excise t axes and duties paid or allowed by the selling part y and any other governmental charges imposed upon the product ion, importation, use or sale of such Product ; ( ii ) customary trade, quantity and cash discounts a llowed on Product ; ( iii ) allowances or credits to c ustomers on account of rejection or return of Product or on acc ount of retroactive price reductions affecting such Product ; ( iv ) freight and insurance costs ; ( v ) rebates, chargebac ks and other amounts paid on sale or dispensing of the Product ; and ( vi ) the booked cost of devices or sys tems used for delivering a Product into the patient where the Product when sold is a 4 combination of the active pharmaceutical ingredient and the device or system . For the avoidance of dou bt, for each Product the Net Sales shall be calculated only once for the first sale of such Product by either Spectrum, its Affiliate, its sublicensee or its distributor, as t he case may be, to a Third Party which is neither a n Affiliate, sublicensee or distributor of Spectrum . A sale of P roducts by Spectrum, its Affiliate, its sublicensee or its distributor to a wholesaler shall be regarded as th e first sale of the Product for the purpose of calc ulating Net Sales unless such sale is made by one of them direc tly to a hospital, pharmacy, physician, retailer or other entity which provides the Product to the patient in which case the first sale shall be the sale to such hospi tal, pharmacy, physician, retailer or other entity . Net Sales shal l not include the amount received on account of sal es of a Product or of sales of a Product in a particular co untry for which the term of this Agreement has expi red in accordance with Section 11.1 on or before the date of the invoice for such sales