definiens: shall mean any ( a ) line extension of the Product ; ( b ) new indication of the Product ; ( c ) composition or matter or article of manufacture consisting essentially of a chemical derivative of Amphotericin B ; ( d ) pharmaceutical combination containing the Product and another acti ve ingredient ; ( e ) new formulations or new dosage forms comprising a lipid or liposomal combination or formulation of Amphotericin B ; ( f ) other combinations or formulations comprising Amphotericin B, or any chemical derivatives thereof, with respect to whi ch the [COMPANY] Companies or their Affiliates are conducting or have conducted clinical or pre -clinical research prior to the date hereof ( including any aerosol formulations of or combination products with Amphotericin B ) ; and/or ( g ) the making, having made, u sing, selling, offering for sale or importing of such compositions of matter or articles of manufacture constituting any of the foregoing . Product Improvements shall not include any composition of matter or article of manufacture which contains or is made or manufactured using any Excluded Technology