definiens: means a polypeptide that Targets an antigen, whic h polypeptide comprises : ( a ) one or more immunoglobulin variable domains ; ( b ) one or more fragments, variants, modifications or derivat ives of such immunoglobulin variable domains irrespective o f origin or source, including antigen binding porti ons, fragments ( including Fab, Fab ’, F(ab’)2, Fv, dAb an d CDR fragments ), single chain antibodies ( scFv ), c himeric antibodies, monospecific antibodies, bispecific ant ibodies, multi - specific antibodies, diabodies and o ther polypeptides, any of which contain at least a porti on of an immunoglobulin variable domain that is suf ficient to confer specific antigen binding to the polypeptide ; or ( c ) in each case ( a ) and ( b ) above, humanized o r fully human versions thereof