definiens: means Patent Rights Controlled by [COMPANY] during the Term that claim(a ) an siRNA targeting the human TTR gene contained in a Licensed Product, ( b ) during the Exclusivity Period, ansiRNA targeting the human TTR gene not contained in a Licensed Product and not contained in an AlnylamDevelopment Candidate, ( c ) the composition of matter of ( i ) a Licensed Product or ( ii ) an siRNA targeting the humanTTR gene together with a formulation or compound that mediates delivery of an siRNA Product, which combination iscontained in a Licensed Product, ( d ) methods of using a Licensed Product as a human therapeutic or prophylactic, methods of using a Licensed Product to modulate human TTR, or methods of using a Licensed Product to inhibitexpression of human TTR, or ( e ) methods and materials specific to the synthesis or analysis of a Licensed Product;provided however, patents that include claims that are directed to subject matter applicable to siRNA or siRNA deliveryin general will not be considered [COMPANY] Product Specific Patents but will be considered [COMPANY] Core TechnologyPatents . Notwithstanding the foregoing, for the purposes of clause ( b ) above, [COMPANY] Product - Specific Patents shall notinclude any Patent Right that claims any siRNA targeting the human TTR gene that ( A ) is contained in an AlnylamDevelopment Candidate and ( B ) is not contained in a Licensed Product . The [COMPANY] Product - Specific Patents existingas of the Effective Date are identified on Schedule 1.16 . Notwithstanding the foregoing, [COMPANY] Product - SpecificPatents shall exclude [COMPANY] ’s interest in Patent Rights included in Joint Collaboration IP