definiens: means any two ( 2 ) compounds other than RP5264 as provided in Exhibit G Controlled by Rhizenas of the Effective Date and/or developed during the Term, which ( i ) falls within the chemical genus provided in ExhibitB, and ( ii ) has targeted nanomolar potency ( ≤ 50 nM ) in an in vitro enzyme assay against the PI3Kδ target and targetedspecificity of no less than 20x compared to the PI3 K α, β, and γ isoforms . However, this targeted specificity will not beused to exclude consideration of individual backup compounds by JSC, or to limit the ability of JSC to select particularbackup candidates for further development provided that targeted PI3Kδ specificity is no less than 8x compared to PI3Kα, β, and γ isoform . The initial list of the Backup Compounds is attached hereto as Exhibit G and shall be updated fromtime to time by Rhizen and provided to JSC promptly . The list of the Backup Compounds thus updated shall include anycompound which falls in the above definition which are discovered or developed by Rhizen during the Term