definiens: means the as defined in the Amended and Restated Collaboration and LicenseAgreement for the United States dated as of November 18, 2013, by and between Pozen and AstraZenecaAB ( which agreement was assigned to Horizon Pharma USA, Inc. ), that certain Amended and RestatedCollaboration and License Agreement for Outside the United States, dated as of November 18, 2013, by andbetween Pozen and AstraZeneca AB, and that certain letter agreement dated as of November 18, 2013, byand among AstraZeneca AB, Pozen and Horizon Pharma USA, Inc., each as amended from time to time priorto the date hereof, and includes Esomeprazole magnesium and Naproxen delayed release tablet, including375 mg ( Naproxen ) / 20 mg ( Esomeprazole magnesium ) and/or 500 mg ( Naproxen ) / 20 mg ( Esomeprazolemagnesium ) dosage strengths