definiens: means, for each P arty, those efforts and resources comparable to those normally used by such Party her eunder for a product or compound owned by such Party or to which such Party has rights of the type such Party has hereunder, taking into account, without limitation, issues of safety and efficacy, product profile, the proprietary position of the pr oduct or compound, the regulatory environment and status of the compound, and other relevant scientific factors, market conditions then prevailing, includi ng the competitive environment, profitability, the extent of market exclusivity, the cost to Develop t he compound or product, health economic claims, and other similar factors reasonably determined by the Party to be relevant . Without limiting the foregoin g, Commercially Reasonable Efforts as it applies to th e clinical development of the Licensed Compound and Product hereunder means implementation of the D evelopment and Regulatory Plan in accordance with the time lines set forth therein to the extent that such implementation in accordance with such t ime lines is controllable by the Party responsible for performing such implementation, and subject to ( i ) any amendment of such Development and Regulatory Plan f rom time to time in accordance with Section 3.2.1 based on the results of studies condu cted with the Licensed Compound and Product, and ( ii ) regulatory, safety, and efficacy factors, [ * * ] set 5 forth therein . Without limiting any of the foregoin g, for all purposes of Section 4.3.5, shall take into account [ * * ] . as used in this Agreement will be interpreted in a corresponding ma nner