definiens: means, withrespect to a Product, the level of efforts required to carry out a task in a diligent and sustainedmaiu ~ er without undue interruption, pause or delay ; which level is at Least commensurate with thelevel of efforts that a similarly situated biopharmaceutical company would devote to a product ofsin ~ ilal• nlai - ket potential at a similar• stage in development or product life .. taking into account thefollowing factors : issues of safety and efficacy ' ; the competitiveness of alternative products ; thepatent or other proprietary position of the Product ; pricing and reimbursement ; product profile, difficulty in and costs of developing or n7ailufacturing the Product, competitiveness of theProduct a11d alternative Third Party products ii1 the marketplace, the re ~ ulatoi -y structureinvolved in developing and commercializing the product ; the potential profitability of theProduct marketed or to be marketed : and all other relevant scientific, technical and commercialfactors . Commercially Reasonable Efforts shall be determil ~ ed on acountry - by - country basis, and it is anticipated that the level of effort will change over time r ° effecting changes in the statusof the Product and the market involved . [COMPANY] shall, for each Target foi- which the Option isexercised, devote Commercially Reasonable Efforts to preclinically aald clinical]y develop ; seekMarketing Authorization for, and launch and actively commercialize a~ least one ( 1 ) Productcontaining a Licensed Antibody to such Target, for the Major Markets