definiens: means a collaboration involving the discovery and development of DoubleStranded RNA Products in which a Party plays an integral role in the experimentation and an important, though notnecessarily dominant or co - equal, role in the decision - making, relating to the discovery and development of DoubleStranded RNA Products from the point in time at which the relevant Gene Target has been designated through theinitiation of [ * * ] . A Bona Fide Drug Discovery Collaboration may continue beyond the initiation of such [ * * ] . For IsisProducts that are Double Stranded RNA Products, a Bona Fide Drug Discovery Collaboration must be an Antisense DrugDiscovery Program . For each Party, collaborations that do not include or involve Patents licensed from the other Partyhereunder shall not constitute Bona Fide Drug Discovery Collaborations . A Party ’s experimentation relating to thediscovery and development of Double Stranded RNA Products that modulate a relevant Gene Target prior to thecommencement of a collaboration shall be deemed to have been conducted in the course or the collaboration forpurposes or detennining whether the collaboration is a Bona Fide Drug Discovery collaboration . A series of relatedcollaborations and/or license agreements involving the discovery and development of Double Stranded RNA Productswith the same sublicensee or related sublicensees that includes a Bona Fide Drug Discovery Collaboration agreementwill be aggregated to constitute a single Bona Fide Drug Discovery Collaboration