definiens: Decision shall mean Genentech ’s internal approval of a program to begin lead optimization as evidenced by minutes of the Genentech Research Review Committee ( or any equivalent successor governance body in the event o f a restructuring ) ( the or ), which in any event shall occur prior to [ * * ] . In determining whether a program under this Agreement should be proposed for consideration for the Late Stage Research Go Decision or should begin lead optimization, Genentech shall use standards that are co nsistent with those applied to its internal programs . If a research program for a Target is brought to Genentech ’s Research Review Committee for an LSR -Go decision and does not achieve LSR -Go, then, on written request from Constellation, Genentech ’s [ * * ] ( or his designee, having appropriate expertise ) and the [ * * ] of Constellation ( or his designee, having appropriate expertise ) shall meet ( in person, via video conference or telephone ) to discuss such decision and the standards applied thereto