definiens: shall mean : ( a ) with respect to the research of an Antigen or Antibody, efforts and resourcescommonly used in the research - based pharmaceutical industry or, solely with respect to the performance of theResearch Programs by ABX ( but not its activities with respect to the development, manufacture andcommercialization of Licensed Products ) efforts and resources commonly used in the established biotechnologyindustry ; 12 ( b ) with respect to the development of an Antigen, Antibody or resulting Product, effortsand resources commonly used in the research - based pharmaceutical industry ; ( c ) with respect to the commercialization of a Licensed Product or any product withrespect to a Co - Development Antigen, efforts and resources commonly used in the research - based pharmaceuticalindustry and, solely with respect to the commercialization of ABX Products that bind to and are directed against aDiscontinued Antigen, efforts and resources commonly used in the established biotechnology industry ; ( d ) with respect to the manufacture of an Antibody or a Licensed Product, efforts andresources commonly used in the research - based pharmaceutical industry or, solely with respect to ABX ’s processdevelopment and manufacturing of Products, efforts and resources commonly used in the contract manufacturingindustry by those contract manufacturing organizations that provide process development and clinical and commercialscale cGMP manufacture of antibody therapeutics on a commercial basis ; in each case for an antigen, antibody or product of similar commercial potential at a similar stage in its lifecycle, taking into consideration its safety and efficacy, its cost to develop, the competitiveness of alternative products, theintellectual property landscape, the likelihood of regulatory approval, its profitability and other relevant factors