definiens: shall mean, with respect to a particular time period, the total amounts received orinvoiced by [COMPANY], its collaborators ( expressly including Takeda ), licensees or their respective sublicensees for sales ofFinished Product made during such time period to unaffiliated Third Parties, less the following deductions to the extentactually allowed or incurred with respect to such sales : ( i ) discounts, including cash and quantity discounts, charge - backpayments, and rebates actually granted or administrative fees actually paid to trade customers, patients ( including those in theform of a coupon or voucher ), managed health care organizations, pharmaceutical benefit managers, group purchasingorganizations, federal, state, or local government and the agencies, purchasers and reimbursers of managed healthorganizations, pharmaceutical benefit managers, group purchasing organizations, or federal, state or local government, including without limitation ( a ) any reasonable inventory compensation due to revision of the approval by the Ministry ofHealth, Labor and Welfare ( otherwise referred to as ), or any successor thereto that governs the scientific review ofhuman pharmaceutical products in Japan, of the National Health Insurance System ’s reimbursable price for the Product inJapan and its territories and possessions, and ( b ) any contribution for Drug Induced Suffering and Contribution for Measurefor Drug Safety ( as required by Law or applicable Regulatory Authorities ), in the amount determined by the Pharmaceuticalsand Medical Devices Agency ( so - called ) in Japan ; ( ii ) credits or allowances actually granted upon prompt payment orclaims, bad debts and losses actually incurred as a result of actual write - offs of uncollectible customer accounts, damagedgoods, rejections or returns of such Finished Product, including in connection with recalls ; ( iii ) packaging, freight, postage, shipping, transportation, warehousing, handling and insurance charges, credit card processing fees and any [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THESECURITIES EXCHANGE ACT OF 1934, AS AMENDED