definiens: means, with respect to the efforts to be expended by a Party with respect to any objective(e.g ., Development Activities and Commercialization hereunder ), the level of efforts consistent with the efforts and resources [ * * * ] of similarmarket potential, at a similar stage in development or product lifecycle, taking into account the stage of development or product lifecycle ofother of [ * * * ] product candidates, safety and efficacy, product profile, cost of goods, the competitiveness of the marketplace, suchcompany ’s patent position with respect to such product ( including such company ’s ability to obtain or enforce, or have obtained or enforced, such patent rights ), the Third Party patent landscape relevant to the product, the regulatory structure involved, the likelihood of regulatoryapproval, the likelihood and extent of anticipated or actual profitability of the applicable product, and other technical, legal, scientific andmedical considerations . Without limiting the foregoing, Commercially Reasonable Efforts requires, with respect to such obligations, that aParty : ( i ) promptly assign responsibility for such obligation to specific employee(s ) who are held accountable for progress and monitor suchprogress on an on - going basis, ( ii ) set objectives for carrying out such obligations, and ( iii ) allocate resources designed to advance progresswith respect to such objectives