definiens: Direct Gene Ex ression A ent T e 1 " shall mean an harmaceuticall active agent which is ( a e physiologically occurring orm of the translation roduct of the non - diseased variant of a Disease Gene and conceived and reduced to practice as a result of a Research Program by a Party, its Affiliate or its Collaborator at anv time puring a period com!!lencing gn the Effective Oate and ending five ( 5 ) years after a first · Validated Target has been obtained for the Selected Disease the pathogenesis of which ; s affected by thel?isease Gene-¥ -1 .27 shall mean any pharmaceutical ! active a ent which agent is ( a the physiologically occurring orm 0 e rans ation pro uct of a gene tha enco es another me the Biolo ical Pathway of which the roduct of a Disease Gene is a member nd ( b ) conceived and re uced to prac Ice as a result of a Researc rogram by a Party, its Affiliate or its Collaborator at any time durinlr : li~9.flve ( 5 ) years after a first Vahdated Target has been obtained for fhe Selected Disease the pathogenesis of which is affected by the Disease Gene