definiens: shall mean any and all Know - How, patentable or ot herwise, including animal models, manufacturing technology and in vivo and in vitro screening assays and methods for optimization and characterization of compounds that is : ( i ) Controlled by NGM or any of its Affiliates ( subject to Section 14.3 ) as of the Execution Date or during the Term ; and ( ii ) ( a ) to the extent Controlled during the Full Research Program Term, i s reasonably necessary or useful, or ( b ) to the extent only Controlled after the expiration of the Full Research Program Term, is reasonably necessary, in each case of ( ii ) ( a ) and ( b ), for the research, Development, manufacture, use or Commercialization of Optioned Compounds, Optioned Products, Small Mol ecule Collaboration Compounds or Small Molecule Products ; provided, however, that shall not include any of NGM ’s proprietary gene or peptide delivery technologies t hat are used solely for research purposes, includin g discovery of antibodies, peptides or other large mo lecule or small molecule compounds . For the purpose of clarity, pertains to Opti oned Compounds, Optioned Products, Small Molecule Collaboration Compounds and/or Small Molec ule Products, as opposed to which pertains to NP201 Compounds, NP201 Produ cts and NP201 Targets . There may be overlap between and to the extent Know - How satisfies both definitions