definiens: means the equivalent of the work of one employee fu ll time for one year ( consisting of at least a total of 45.5 weeks or 1,820 hours per year ( exclud ing vacations and holidays ) of work on or directly related to the Agreement ), carried out by an Isis employee . Th e FTE rate will be ( i ) [ * * * ] ( U.S. ) per FTE for any of the following activities : drug substance manufacturing ; analytical chemistry ; process chemistry ; formulati on ; raw material ordering and handling ; quality control ; or manufacturing technology transfer ; and ( ii ) [ * * * ] ( U.S. ) per FTE for any of the following activities : toxicology ; pharmacokinetics / metabolism ; regulatory ; clinical development ; or data management . These FTE rates wi ll be adjusted upward on a Calendar Year basis commencing January 1, 2009 ( and on January 1 of eac h year thereafter during the Term of this Agreement ) by a factor which reflects [ * * * ] for [ * * * ] during the Te rm of the Agreement when compared to the [ * * * ] in t he preceding year