definiens: will be construed accordingly . 1.28 means, with respect to the Exploitation of a Lice nsed Product by a Party, those efforts and resources, including all ocation of reasonably necessary personnel, equivale nt to the efforts that a reasonable global biopharmaceuti cal company or a pharmaceutica l company, in each case, that is of comparable size and resources to s uch Party would typically devote as part of an acti ve and continuing program of development and commercia lization of a pharmaceutical or biologic product of similar market potential, at a similar stage of its product life and taking into account all relevant factors, facts, and circumstances, including the competitive ness of the marketplace and the proprietary positio n, product profile, the patent or other intellectual p roperty status ( in cluding the strength and duration of patent protection and anticipated exclusivity ), the likelihood and timing of Regulatory Approvals and Reimbursement Approvals, the current guidance and r equirements for Regulatory Approvals and Reimbursement Approvals, the then and projected regulatory status, the abili ty to Manufacture or have Manufactured such product, labeling considerations, safety, tolerability, stability and efficacy, pres ent and future market potential and performance, existi ng and projected prici ng, sales, reimbursement and profitability, pricing or reimbursement changes in relevant countries or regulatory jurisdictions