definiens: means:(a ) with respect to EPIZYME, subject to the last paragraph of this Section 1.15, such efforts that areconsistent with the efforts and resources normally used by EPIZYME in the exercise of its reasonable businessdiscretion relating to the Development and Commercialization of a potential pharmaceutical product:(i ) that is at a similar stage in its Development or product life as the relevant Compound, LicensedCompound or Licensed Product ; and(ii ) that has commercial and market potential similar to the relevant Compound, LicensedCompound or Licensed Product, taking into account issues of intellectual property scope, subject matter andcoverage, safety and efficacy, product profile, competitiveness of the marketplace, proprietary position andprofitability ( including pricing and reimbursement status achieved or likely to be achieved, and royalties and otherpayments required under this Agreement ) ; and(b ) with respect to EISAI, such efforts that are consistent with the efforts and resources normally usedby EISAI in the exercise of its reasonable business discretion relating to the Development and Commercialization of apotential pharmaceutical product:(i ) that is at a similar stage in its Development or product life as the relevant Compound, LicensedCompound or Licensed Product ; and - 3 -(ii ) that has commercial and market potential similar to the relevant Compound, LicensedCompound or Licensed Product, taking into account issues of intellectual property scope, subject matter andcoverage, safety and efficacy, product profile, competitiveness of the marketplace, proprietary position andprofitability ( including pricing and reimbursement status achieved or likely to be achieved, and royalties required underthis Agreement )