definiens: shall mean any formulation containing as an activeconstituent ( i ) a humanized immunoglobulin having complementarity determining regions, as disclosed in U.S. Patent No . 5,840,299 ( or any functionally equivalent modificationthereof ), and heavy and light chain variable frameworks from predominantly humanacceptor immunoglobulin ; ( ii ) an antigen - binding fragment of such humanizedimmunoglobulin having at least ten ( 10 ) amino acids ; or ( iii ) any such immunoglobulin orfragment as described in ( i ) and ( ii ) or any other fragment comprising the complementaritydetermining region of such humanized immunoglobulin, fused to another polypeptidefragment or another monomeric or polymeric compound, in each case under clauses ( i),(ii ), and ( iii ), which specifically binds to an Alpha-4 Integrin and which has a molecularweight greater than 2,000 Daltons