definiens: means, with respect to a particular item and a particular Patent, that, in anyof the countries of manufacture, use, or sale, ( a ) the composition of such item, of any of its ingredients orformulations, or of any product containing such item or that is made using such item by virtue of such productcontaining or being made using such item ; ( b ) a method of making or using any of the foregoing things referredto in ( a ) ; ( c ) an item used or present in the manufacture of any of the foregoing things referred to in ( a ) or ( b ) ( forexample, with respect to a biologic, any vector, plasmid or cell line used to manufacture such product or itemor any ingredient in either of them ) ; or ( d ) any method by which the foregoing things referred to in ( a ), ( b ), or ( c)was discovered or identified, or another item present during or used in such method would, in the absence of alicense or assignment, infringe a valid claim of such Patent