definiens: means, with respect to the efforts to be expended by a Party withrespect to any objective under this Agreement, reasonable, diligent, good - faith efforts to accomplishsuch objective as [ * ] would normally use to accomplish a similar objective under similarcircumstances, it being understood and agreed that, with respect to the Manufacture, Development, conduct of Medical Affairs Activities with respect to, and Commercialization of a Licensed Product, such efforts shall be substantially equivalent to those efforts and resources commonly used by [ * ] fora product owned by it or to which it has rights, which product is of similar market and economicpotential as the Licensed Product, and at a similar stage in its Development or product life as theLicensed Product, taking into account efficacy, safety, approved labeling, the competitiveness ofalternative products in the marketplace, the patent and other proprietary position of the product, thelikelihood of Regulatory Approval given the regulatory structure involved, the profitability, and otherrelevant factors commonly considered in similar circumstances, in any event exercising reasonablebusiness judgment