definiens: means, subject to early termination with respect to any Development Program orexercise by EPIZYME of an EPIZYME Post - EOP1 Clinical Opt - Out pursuant to Section 2.5 or an EPIZYME LateStage Opt - Out pursuant to Section 2.6 with respect to a Shared Development Program, on a Development Program - by - Development Program basis, the period commencing upon CELGENE ’s exercise of the Phase 1 Option withrespect to the applicable Selected Target ( unless such exercise is prior to the End of Phase 1 Date with respect to aCompound Directed to the applicable Selected Target, in which case commencing upon the End of Phase 1 Date withrespect to such Selected Target ), and ending on the date when all Regulatory Approvals have been granted by boththe FDA and EMA for all Licensed Compounds and Licensed Products for all Indications in such DevelopmentProgram, in each case, for which the JDC, in the case of DOT1L and [ * * ], and CELGENE, in the case of [ * * ] and [ * * ], has determined to pursue Regulatory Approval, provided that, with respect to the Development Program for DOT1L, the Parties agree that the Development Term commenced prior to the Effective Date under the Original Agreementand continues under this Agreement and, with respect to Development Programs for Available Targets that becomeSelected Targets pursuant to Section 2.4 or Section 2.5, the Development Term shall commence upon such AvailableTargets becoming Selected Targets