definiens: means, with respect to a Party, efforts that are consistent with the efforts and resources commonly used in the pharmaceutical industry by a company of comparable size in connection with the research, de velopment and commercialization of a pharmaceutical or biologic compound or product owned by it or to whic h it has exclusive rights, with similar product cha racteristics, which is of similar market potential at a similar s tage in its development or product life, taking int o account issues of patent coverage, safety and efficacy, product pr ofile, the competitiveness of the marketplace, the proprietary position of the compound or product, the regulatory and legal structures involved, the potential or ac tual profitability of the applicable compound or product ( including pricing and reimbursement status achiev ed or to be achieved ) and other relevant factors, including tec hnical, legal, scientific and/or medical factors . C ommercially Reasonable Efforts shall be determined on a market- by - market and indication - by - indication basis for a particular product, and it is anticipated that the level of ef fort shall be different for different markets withi n the Territory and different indications, and shall change over time, reflecting changes in the status of the product and the market(s ) and indication(s ) involved