definiens: shall mean efforts and diligence in developing and commercializing LICENSED PRODUCTS, and inundertaking investigations and actions required to obtain regulatory approvals, necessary to marketLICENSED PRODUCTS in the LICENSED FIELD in the Territory, such reasonable efforts and diligence tobe, on a country - by - country basis, in accordance with the efforts and resources LICENSEE would use fora product candidate owned by it or to which it has rights, which is of similar market potential as theapplicable LICENSED PRODUCT, taking into account the competitiveness of the marketplace, theproprietary position of the LICENSED PRODUCT, the relative potential safety and efficacy of theLICENSED PRODUCT, the cost of goods and availability of capacity to manufacture and supply theLICENSED PRODUCT at commercial scale, the profitability of the applicable LICENSED PRODUCT, andother relevant factors including, without limitation, technical, legal, scientific or medical factors . CRE doesnot include LICENSEE [ * ] a LICENSED PRODUCT ( including active study of dosage, formulation, orsafety issues ) for [ * ]