definiens: means any event that has a material, adverse effect on themanufacture, distribution, marketing or sale by or on behalf of the Purchaser of the Product in theTerritory as contemplated by this Agreement and the Ancillary Agreements, but excluding the events oreffects of : ( i ) changes to the pharmaceutical industry and markets in which Purchaser or Seller operate, to the extent such changes do not have a disproportionately adverse effect on the Intended Use of theProduct in the Territory ; ( ii ) changes in the United States or world financial markets in general ; ( iii)changes arising in connection with earthquakes, hostilities, acts of war, sabotage or terrorism or militaryactions or any escalation or material worsening of any such hostilities, acts of war, sabotage or terrorismor military actions existing or underway as of the date hereof ; or ( iv ) any action taken by Purchaser or itsAffiliates with respect to the transactions contemplated hereby or with respect to a Product or theIntended Use of a Product in the Territory ; or ( v ) any effect resulting from the public announcement ofthis Agreement, compliance with terms of this Agreement or the consummation of the transactionscontemplated by this Agreement