definiens: Development Costs " shall mean all internal ( direct and indirect ) and Third Party expenses incurred by EPIX in connection with the Research Program, or by SCHERING following exercise of the SCHERING Option, determined in a reasonable manner in accordance with GAAP . Such expenses include, but are not limited to ( i ) direct labor ( salaries, wages, incentive awards and employee benefits but excluding any employee benefits associated with equity incentive plans ) ; ( ii ) materials and supplies ; ( iii ) allocated Costs for building space directly dedicated to the development of the Lead Compounds, Development Candidates and/or Licensed Products ( including rent, depreciation, amortization and maintenance ) but excluding expeQses relating to unused capacity, development of other products, and amortization of property, plant and equipment not directly related to development of Lead Compounds, Development Candidates and/or Licensed Products ; ( iv ) Third Party contracts and consulting expenses incurred for services in connection with the development of Lead Compounds, Development Candidates and/or Licensed Products ; ( v ) allocated Costs for infonnation technology directly dedicated to the development of the Lead Compounds, Development Candidates and/or Licensed Products ; and ( vi ) travel and entertainment, telephone, recruiting, training ( both internal and external ), clinical trial insurance, software, personal computer equipment and support Costs and freight and delivery expenses . Such Costs shall not include General and Administrative Expenses or expenses incurred from departments that are not directly engaged in the development of the Lead Compounds, Development Candidates and/or Licensed Products including, but not limited to, finance and procurement, corporate administration, legal ( both external and internal expenses ), human resources, business development and licensing, sales and marketing except for Costs of investor relations