definiens: means, the use, research or development(whether in vitro or in vivo ), or commercialization of any Enzyme or Enzyme fusion protein(except where the use of any Enzyme or Enzyme fusion protein which is used by [COMPANY] solely : ( i)as a research reagent or a research tool, or ( ii ) to synthesize any [COMPANY] Compound ), that:(a ) effects a chemical transformation in humans, ( b ) facilitates, assists or enables the action, dispersion, absorption or bioavailability of a molecule, biologic agent, drug product, therapeuticagent, or other compound ( other than such Enzyme or Enzyme fusion protein ) in humans, or(c ) transports a molecule, biologic agent, drug product, therapeutic agent, or any other compound(other than such Enzyme or Enzyme fusion protein ) in humans, in each of cases ( a ) through ( c)for any purpose, including without limitation the use of Enzymes for medicinal or therapeuticpurposes, such as the treatment of lysosomal storage diseases, removal of toxic metabolites andby - products resulting from defects in metabolism, metabolite depletion therapy ( e.g., for thetreatment of cancer ), permeabilization of tissue for improved uptake of a molecule, biologic agent, drug product, therapeutic agent, or any other compound into cells ( e.g., hyaluronidase typeapplication, [ * * * ], etc . ), as well as combinations of the above ; provided that the [COMPANY] ExclusiveField [ * * * ]