definiens: means issued patents and patent applications listed on Exhibit Aattached hereto and any renewals, divisions, continuations, extensions or reissues based thereof, andcontinuations - in - part to the extent the claims of the continuation - in - part are supported by the disclosure in theparent application and any new matter added to the continuation - in - part is unencumbered by a Third Party andsupports the claims of the parent application, and any corresponding foreign patent applications, and anypatents, patents of addition or other equivalent foreign patent rights issuing, granted or registered thereon ; ineach case to the extent that such patent or other right contains a claim that covers, and solely to the extentthat any such claim covers, an Onco Methylation Marker(s ) ; provided, however, that the method claimscontained in the 4 patent application titled ( priority date 03 - Feb-09 ) onExhibit A ( and the inventions disclosed and claimed therein ) are expressly excluded to the extent that theyrelate to or cover the combination of ( i ) detection of epigenetic modification with ( ii ) detection of blood insamples