definiens: shall mean : ( i ) the Collaboration Agreement dated as of June 14, 2013 by and between MedImmune Limited and NGM, as amended by that cert ain Amendment to Collaboration Agreement dated February 14, 2014 ; ( ii ) the Research Collaboration and License Agreement dated as of March 26, 2012 by and between Daiichi Sankyo Company Limited and NGM ; and ( iii ) the Research, Development and Commerciali zation Agreement dated as of September 7, 2011 by and between Juvenile Diabetes Research Foundatio n International and NGM, as amended by that certain First Amendment to the Research, Developmen t and Commercialization Agreement dated as of August 14, 2013 ; in each case, as any such agreemen t may subsequently be amended from time to time following the Effective Date by such parties, in ac cordance with, and subject to, Section 4.8