definiens: means any decision that is not a [ * * * ] with respect to [ * * * ] matters relating to theDevelopment or Commercialization of any Co - Commercialized Product for any Indication in the Co - CommercializationTerritory, including matters related to Sections 2.3.4(e ) and ( g ), but excluding decisions relating to the [ * * * ] portion of theDrug Approval Application for the Product for the Indication of [ * * * ] in the U.S. Territory ; provided, that any SYNTADecision can not ( a ) result in an increase of more than [ * * * ] percent ( [ * * * ] % ) in any annual budget applicable to a Product;(b ) commit [COMPANY] to perform any activity that conflicts with [COMPANY] Internal Policies ( or decisions of the [COMPANY] Global ClinicalSafety Board ) or Applicable Laws ; ( c ) conflict with an approved Global Development Plan or Product Co - CommercializationPlan ; or ( d ) be detrimental to the global Branding applicable to a Product