definiens: shall mean ( i ) either ( a ) [COMPANY] has initiated a follow - up clinical study with the same CARconstruct as used in the CRUK Study ; or if necessary ( b ) [COMPANY] has initiated formal pre - clinical development of a new GD2Product not used in the CRUK Study ; and ( ii ) as soon as is reasonably practicable following marketing approval of the GD2 Productin each of the relevant territories, [COMPANY] ( or its Sub - licensee ) has commenced sale of the GD2 Product in either ( a ) the [ * * * ] ( ifreimbursement has been granted in the [ * * * ] ) and one other Core Country or one of [ * * * ] or ( b ) at least any two of [ * * * ] or any of theCore Countries ( other than the [ * * * ] ), in the event reimbursement is not granted in the [ * * * ] ; v