definiens: means ( a ) the one or more Targets associated with A ML that are selected by Kite as Program Targets from the list of Target Can didates on Exhibit E by written notice to CDL withi n [ … * * * … ] of the Effective Date and thereafter listed on Exh ibit D, ( b ) if the Option is exercised by Kite purs uant to Article 4, the one or more Targets that are selected by Kite a s Program Targets for B - Cell Malignancies from the list of Target Candidates on Exhibit E in connection with such Opt ion Exercise, and otherwise, as Exhibit D and Exhib it E may be amended from time to time pursuant to Section 2 . 1(d ) . For clarity, upon designation by Kite as a Pr ogram Target, each Target shall no longer be considered a Target Candidate and shall be removed from the list on Exh ibit E.