definiens: shall mean all Patent Rights ( all as listed on Exhibit 1.41 ) and all information, materialsand other subject matter, and improvements thereof, relating to ( i ) mutants or the use thereof in screening, ( ii ) the use of novelprotein engineering techniques and their application in drug discovery, ( iii ) target - directed fragment discovery and maturationto produce drug leads, including monophores, extenders and fragments and monophore, extender and fragment libraries forsuch purposes, or ( iv ) covalent tethering and techniques related thereto ( e.g., NMR, X - ray, mass spec . AUC, Biacore ) and itsuse to discover fragments and test binding hypotheses of fragments and leads : ( a ) Controlled by Sunesis or its controlledAffiliates prior to the Original Agreement Effective Date or during the Research Term ; or ( b ) made by Biogen Idec in thecourse of activities directed to the discovery, research, or development of Licensed Compounds and PDK Compounds;provided, in the case of ( b ) that such item was made using or derived from Sunesis Core Technology