definiens: means, with respect to a Party ( directly or through Aﬃliates orSublicensees ) performing activities under this Agreement, such reasonable, diligent, and good faith eﬀorts as such Partywould normally use to accomplish a similar objective under similar circumstances, but no less than the eﬀorts and resourcescommensurate with those eﬀorts commonly used in the pharmaceutical industry by a company of comparable size inconnection with the Development, Manufacture or Commercialization of pharmaceutical products of similar market potentialat a similar stage of Development or Commercialization in its product lifecycle, taking into account market and economicconditions then prevailing, including the competitive environment, proﬁtability, the extent of market exclusivity, the cost toDevelop, Manufacture or Commercialize the Products, and other similar factors ; provided, however, that, with respect toSanten ’s obligations under this Agreement, Commercially Reasonable Eﬀorts do not include seeking to optimize or maintaina certain level of proﬁts in favor of any other product researched, developed or commercialized by Santen or in whichSanten will share profits or revenues from the sale thereof that competes with the Product in the Field