definiens: means the cost of labor, raw materials, scrap, obsolescence . supplies and other resources direclly consumed in the conduct of and in accordance wiLlI the Research and Development Program and the manufacture of the Collaboration Product for use in preclinical and clinical trials and pre­commercialization activities . For purposes of this definition . means the cost of facilities, utilities, insurance ( including any product liability insurance or accrual for self­insurance ), facility and equipment depreciation and other fixed costs directly related to the conduct of the Research and Development Program and the manufacture of the Collaboration Product for use in preclinical and clinical trials and pre - cornmercializatioo activities . allocated based upon the proportion of such costs directly attributable to the support or performance of the Research and Development Program and Ihe manufacture of the Collaboration ProduC ( for use in preclinical and clinical trials and pre - commerciali zation activities or by such other method of cost allocation as may be approved by the Board of Directors . AU cost determination s made hereunder shall be made in accordance with GAAP . Research and Development Costs shall exclude all costs otherwise reimbursed pursuant to this Agreement