definiens: means oligonucleotide- or oligonucleotide derivative­based therapeutic modalities for gene function modulation or other moieties effective in gene function modulation that function through RNA interference and which are discovered, derived or developed by ALNYLAM or any person or entity acting on its behalf, including its Affiliates, consultants and scientific advisors during the Collaboration, and which are directed at MERCK RNAi Novel Targets . include, but are not limited to, any and all : ( i ) ALNYLAM Therapeutic Collaboration Inventionsthat are ( a ) oligonucleotide- or oligonucleotide derivative - based therapeutic modalities for gene function modulation or ( b ) moieties which are effective in gene function modulation, and ( c ) function through RNA interference and are directed at MERCK RNAi Novel Targets ; and ( ii ) therapeutic preparations of the RNAi Therapeutic Product in final form for sale by prescription, over - the - counter or any other method for therapeutic use, including, without limitation, any Combination Product