definiens: means any know - how, technical information and/or research, technical, test or development dat a ( including, but not limited to, pre - clinical and clinical data ), along with all formulations, processes, protocols, regulatory files and the like, in each case develop ed by Columbia and/or Institutions to the extent such kno w - how, technical information or data are necessary or useful for the discovery, development, manufacture, use, s ale, offering for sale, importation, exportation, d istribution, rental or lease of a Product, including, without li mitation, ( i ) any know - how, technical information a nd data disclosed in any Patent or ( ii ) any reports or disc losures concerning research or inventions developed by or provided or disclosed to, or otherwise received by, Columbia and/or Institutions . Institutional Techni cal Information will include, but is not limited to, th e information in Exhibit B hereto