definiens: means a nucleic acid - binding protein that Specifically Binds a Gene Target or SafeHarbor Locus, including : ( a ) a Zinc Finger Protein that Specifically Binds a Gene Target or Safe Harbor Locus, ( b ) aTALE Protein that Specifically Binds a Gene Target or Safe Harbor Locus or ( c ) the components of a CRISPR / Cassystem that Specifically Binds a Gene Target or Safe Harbor Locus, which protein or component(s ) of the foregoingclauses ( a)-(c ) may be Operably Linked to ( and thereby include ) ( i ) a wild - type nuclease cleavage domain or othernaturally or non - naturally occuring nuclease, ( ii ) a recombinant nuclease * * * CONFIDENTIAL PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION 6cleavage domain or half - domain or ( iii ) a transcription enhancer or repressor domain ( each of ( i ), ( ii ) and ( iii ), a ) . In this Section 1.42, the terms, ( includingnaturally and non - naturally occuring nuclease ) and shall havethe same meaning as those terms are defined, used and/or exemplified in [ * * * ]