definiens: means ( a ) any Know - How related to the Development, Manufactureand / or Commercialization of any Active Substance or Licensed Product, including any Active Substance ’s orLicensed Product ’s Data and properties, Development, uses, synthesis or manufacture, formulation, or administration(including as contemplated by this Agreement ), and ( b ) any Know - How that is incorporated by [COMPANY] or any of itsAffiliates into the Development, Manufacture, use and/or Commercialization of any Active Substance or LicensedProduct during the Term, which Know - How in each case ( a ) and ( b ) is either ( i ) Controlled by [COMPANY] ( directly or throughany of its Affiliates ) as of the Effective Date or ( ii ) developed outside of the Development Program and comes withinthe Control of [COMPANY] ( directly or through any of its Affiliates ) during the Term, but in all cases excluding [ * ]