definiens: shall mean, with respect to the Product and as to those specific nation(s ) specified in such Manufacturing and Marketing Plan, a detailed business, manufacturing, and marketing plan of the sort prepared internally and used by [COMPANY] and/or its Affiliates ( or, if a license to [COMPANY] under Section 6.8 hereof is applicable, and/or in the circumstances described in Section 4.2 or 4.3 hereof, such a plan of the sort prepared and used internally by [COMPANY] and/or its designated third - party marketer ) with respect to their drug products generally, including without limitation quantifiable and verifiable plans, goals and milestones for the levels and types of resources, personnel, promotion, advertising, detailing, and other efforts to be devoted to the manufacturing, packaging, quality control, and marketing of the Product, and with respect to the measures of the degree of success achieved in doing so, including without limitation target dates for the full - scale market launch of the Product in each specific nation(s ), and Minimum Net Realization(s ) for each specific nation(s ) in such Manufacturing and Marketing Plan ( and related goals and projections for pretax profitability ) . Each Manufacturing and Marketing Plan shall also describe the schedule and methods to be used to effect the revision thereof and the adoption of substituted Manufacturing and Marketing Plans no less often than annually, through Committee Action