definiens: shall mean the gross value of License P ayments, less the following amounts ( the ), to the extent incurred prior to receipt of the foregoing down payments and milestones : i ) The amount of all milestones paid to Orio n Corporation pursuant to that certain License Agreement between Ho rmos and Orion dated December 5, 2002, ii ) The amount of all success fees paid by Ho rmos to Innomedica Ltd, iii ) The amount of all taxes other than income taxes paid or payable by Hormos and any of its Affiliates directly related to the payments described in ( i ) and ( ii ) above ; iv ) The amount of all necessary and reasonabl e research and development costs for obtaining regulatory approval f or the commercialization of ospemifene for any indication, including, without limitation, all of the following : a ) costs accrued after Dec ember 12, 2002 but prior to the effective date of this Agreement, who se definitive value is 3,065,112 EUR ; b ) costs that are paid by Hormos or any of its affiliates after the Effective Date, but before executing any licensing agreement with any licensee of the Ospemifene Patents, and c ) costs that Hormos or any of its Affili ates may be responsible for according to any licensing agreement rela ting to the Ospemifene Patents