definiens: means all Know - How Controlled byAkcea or its Affiliates on the Effective Date or at any time during the Term necessary to Developor Commercialize a Product or disclosed by [COMPANY] to PTC and, in each case specifically relatesto ( a ) the composition of matter of a Product or ( b ) methods of using a Product as a prophylacticor therapeutic ; provided, however, Know - How Controlled by [COMPANY] or any of its Affiliates that ( i)consists of subject matter applicable to oligonucleotide compounds or products in general or ( ii)relates to an oligonucleotide compound that does not specifically modulate expression of aTarget via the binding, partially or wholly, of such compound to RNA that encodes a Target, willnot be considered [COMPANY] Product - Specific Know - How, and in the case of ( i ) and ( ii ), such Know - How will be considered [COMPANY] Core Technology Know - How