definiens: means ( 1 ) licenses granted by [COMPANY] before or after the Effective Date to any Third Party underthe [COMPANY] Core Technology Patents, the [COMPANY] Manufacturing and Analytical Patents, or the [COMPANY] Manufacturing andAnalytical Know - How ( but not under the [COMPANY] Product - Specific Patents ) to ( a ) use oligonucleotides ( or supplyoligonucleotides to end users ) solely to conduct pre - clinical research, or ( b ) enable such Third Party to manufacture orformulate oligonucleotides, where ( i ) such Third Party is primarily engaged in providing contract manufacturing orservices and is not primarily engaged in drug discovery, development or commercialization of therapeutics ; and ( ii)Ionis does not assist such Third Party to identify, discover or make a Compound or Product ; and ( 2 ) material transferagreements with academic collaborators or non - profit institutions solely to conduct non - commercial research