definiens: means, ( a ) for the Initial Project, the period be ginning on the Effective Date and, unless earlier terminated in ac cordance with Section 12.2(b)(ii ) ( Project Termination ), ending on December 4 th, 2018 ; ( b ) for each Additional Project, unless ear lier terminated in accordance with Section 12.2(b)(ii ) ( Project Termination ), the four ( 4 ) year period beginning on the date on which the JRC appro ves the Research Plan for such Additional Project ; and ( c ) for the Agreement as a whole, the period beginning on the Effective Date and ending at the conclusion of the last Research Term to expire or terminate, as each such Research Term may be extended in accordance with Se ction 2.2 ( Project Selection ; Research Term Extension ) or Section 12.2(a ) ( End of Research Term ) or terminated in accordance with Section 12.2.(b)(ii ) ( Project Termination )