definiens: means the equivalent of the work of one ( 1 ) employee working on a dedicated full time basis for one(1 ) year ( consisting of at least a total of [ * * ] hours per year of dedicated effort, excluding vacations and holidays)of work on or directly related to the Research Plan, carried out by an Isis employee or an [COMPANY] employee, asthe case may be . No one person will be permitted to account for more than [ * * ] hours of FTE contribution peryear . Any person who devotes less than [ * * ] hours per year shall be treated as an FTE on a pro - rata basis, basedupon the actual number of hours worked divided by [ * * ] . Scientific work performed in the performance of theResearch Program by an Isis FTE or [COMPANY] FTE may include, but is not limited to, experimental laboratorywork, recording and writing up results, reviewing literature and references, and holding scientific discussions