definiens: shall mean, with respect to any Calendar Year, the total of ( a ) the quantity 0 (, Supplied TMC278 in [COMPANY] 's inventory ( including all work in process for whichcompletion ofl the unlabeled bottles Manufacturing Stage ( ) has not occurred ) at the beginning ofi such Calendar Year, plus ( b ) the quantity of Supplied TMC278 delivered by Tibotec ( or its [ Affiliate ) and accepted by [COMPANY] during such Calendar Year, minus ( c ) the quantity of Supplied I TMC278 remaining in [COMPANY] 's inventory ( including all work in process for which Completionf has not occurred ) at the end of such Calendar Year, minus ( d ) the quantity of Lost TMC278 ( as ) defined below ) during such Calendar Year.l -- . - shall mean, with respect to a Calendar Year, any Supplied TMC278 that was, ", lost or destroyed or that otherwise became unusable during the storage and handling of Supplied I TMC278 by [COMPANY], its Affiliates or contract manufacturers, but, for clarity, excluding any ) -Supplied TMC278 that is determined to have a non - conformity that arose prior to delivery ~ [COMPANY] or its designee under the TMC278 Supply Agreement . ! .-Annex P Page I CONFIDENTIAL EXECUTION VERSION The shall mean, with respect to a given Calendar Year, the quotient ! expressed as a percentage of ( a ) the quantity ( in kilograms ) of Supplied TMC278 containe~ the Combination Product ( calculated on the basis of 0.00075 kilograms of Supplied TMC278 perl Unit ) for which Completion occurred ( ) during such)--Calendar Year divided by~ ) the quantity ( in kilograms ) oflIiput TMC278 for such Calendai ) Year . 1 { Sample Calculati_on ( ) f Annual Yield Rate ( for illustration purposes onlY)J Input TMC278 for the Calendar Year = 0.040 kilograms