definiens: shall mean an agreement between or among SB and/or HGS and ( 1 ) Synthelabo substantial ly in accordance with a memorandum of intent dated March 11, 1996 ; ( 2 ) SP substantially in accordance with a memorandum of intent dated April 21, 1996 ; ( 3 ) Takeda substantially in accordance with the SB / Takeda Collaboration and Li cense Agreement dated June 5, 1995 ; and ( 4 ) a COLLABORATION PARTNER, in addit ion to ( 1 ) and ( 2 ) or substituted for ( 1 ) or ( 2 ), wherein 2 < PAGE > such COLLABORATION PARTNER is granted substantiall y the same licenses and rights as granted by SB and/or HGS pursuant to any one or all of the foregoing agreements pursuant to Paragraph 2.21