definiens: means all Patent Rights Controlledby [COMPANY] or its Affiliates on the Execution Date or at any time during the Term that ( a ) isnecessary or used by [COMPANY] to Exploit the Compound or the Product, and ( b ) claims subjectmatter generally applicable to oligonucleotides, including Conjugate Technology, in each caseother than [COMPANY] Product - Specific Patent Rights or [COMPANY] Manufacturing Patent Rights ; exceptAkcea Core Technology Patent Rights do not include Patent Rights ( x ) specifically directed tooligonucleotide compounds that specifically modulate expression of ANGPTL3 via the binding, partially or wholly, of such compound to RNA that encodes ANGPTL3 ( which will be AkceaProduct - Specific Patent Rights ), or ( y ) claiming formulation technology or delivery devices ( otherthan Conjugate Technology ) . The [COMPANY] Core Technology Patent Rights as of the ExecutionDate are set forth on Schedule 1.8 attached hereto.2165301880Confidential1.9 means $ [ * * * ] per hour . The [COMPANY] FTE Rate will beincreased each calendar year thereafter by the net positive unadjusted percentage change ( ifany ) in the Consumer Price Index published by the Bureau of Labor Statistics, United StatesDepartment of Labor, measured over the 12 - month period ending December 31 of any calendaryear