definiens: means the use of the compound in question in : ( a ) monotherapy or in combination with otherdyslipidemic therapies for the treatment of patients with homozygous familial hypercholesterolemia ; ( b ) monotherapy or incombination with other dyslipidemic therapies for the treatment of patients with severe hypercholesterolemia of any etiologyunable to come within 15 % of NCEP LDL cholesterol goal on maximal tolerated oral therapy, as determined by the patient’sprescribing physician ; ( c ) monotherapy or in combination with other dyslipidemic therapies for the treatment of patients withsevere combined hyperlipidemia of any etiology unable to come within 15 % of NCEP non - HDL cholesterol goal on maximaltolerated oral therapy, as determined by the patient ’s prescribing physician ; and ( d ) monotherapy or in combination with otherdyslipidemic therapies for the treatment of patients with severe hypertriglyceridemia unable to reduce TG<1000 on maximaltolerated therapy