definiens: means any molecule that, as one of its primary mechanisms of therapeutic action, ( i ) specifically binds to or interacts with at least one component of the Wnt Pathway ; and/or ( ii ) modulates the signaling of the Wnt Pathway ; provided, however, Compound shall exclude any molecule that is or incorporates : ( a ) a polypeptide ( e.g., an antibody, antibody fragment, peptide, protein ) or a nucleic acid ( e.g., antisense, RNAi oligos, DNA ) ; ( b ) an antagonist of the Hedgehog Pathway that was tested under the Hedgehog Agreement for activity in modulating the signaling of the Hedgehog Pathway before being tested under this Agreement, in which case, such molecule shall be governed by the Hedgehog Agreement ; or ( c ) a molecule that is ( i ) independently developed by [COMPANY] ( as provided in Section 4.2 ) or ( ii ) in - licensed by [COMPANY] ( including as may be subsequently modified by [COMPANY] ) from a Third Party, in the case of either ( i ) or ( ii ), unless [COMPANY] elects, in its sole discretion, by written notice to [COMPANY] at any time while the [COMPANY] License is in effect, to include such molecule as a Compound, in accordance with Section 3.4(a )