definiens: shall mean any Collaboration Compound that binds to or has activity with regardsto the applicable Collaboration Target and is designated as a Collaboration Lead under Section 2.2(h)(iii ), and in eachcase certain Analogs as described below, along with any derivative, salt, ester, polymorphic, stereoisomer, metabolite, pro - drug form of such Collaboration Compound . Upon designation of a Collaboration Lead under Section 2.2(h)(iii ), such designation shall include those Analogs of the selected Collaboration Compound, which exhibit the samestructure - activity relationship with the applicable Collaboration Target, such structure - activity relationship asmutually agreed in good faith by the JSC, such agreement shall require approval of ( a ) both Parties ' representatives onthe JSC or ( b ) if the term of the JSC has expired or [COMPANY] 's participation on the JSC has ceased, then the approvalof designees of each Party, in each case with a Party 's consent not to be unreasonably withheld