definiens: means any and all processes and activities for the discovery and research of CTLA-4Variants and development of Compounds and associated Products for a particular Indication before the date that is [ * * * * ] from the filing of an IND ( without the applicable Regulatory Authority issuing a clinical hold ) with respect to such Product, or, as applicable, such other time after filing of an IND at which human clinical trials may be first initiated with respect to suchProduct that supports such Indication with respect to the particular Compound, including those processes and activities, whether in vitro or in vivo conducted to : ( i ) discover, screen, optimize, clone, express, purify, formulate, characterize orenhance any Compound, including synthesis or Shuffling of any Compound, conjugation thereof, or similar activities;(ii ) perform IND Enabling Studies with respect to a Compound and ( iii ) discover, develop, optimize, characterize or enhancetechnologies and tools including assays, screens, biological models, software and databases reasonably for the support of or inconnection with any of the activities described in clauses ( i ) and ( ii ) above or Development or Manufacture . For purposes ofthis Agreement, production of Compounds ( and corresponding Product(s ) ) that are not intended to be manufactured inaccordance with cGMP shall be Manufacturing and not Preclinical Development