definiens: means any ( i ) antibody, ( ii ) protein comprising at least one CDR portion thereof ( includingbispecific antibodies, single chain antibodies, domain antibodies and immunoconjugated antibodies ) or ( iii ) adnectin ; in eachof ( i ), ( ii ) and ( iii ), whether human, humanized, chimeric, murine, synthetic or from any other source, that ( a ) has been raised, engineered or otherwise optimized to bind specifically and directly to the Target ( whether exclusively or in addition to anyother target such Antibody may modulate ) and ( b ) competes for binding to the Target with a naturally occurring ligand of theTarget, interferes with Target - Target interaction, or, once bound to the Target, exhibits antagonistic activity against the Target, agonist activity against the Target, ADCC ( antibody dependent cellular cytotoxity ) and/or other F c - mediated effectorfunction