definiens: shall mean[$.hemical that has activity in a Screen and that is created by or for AlIel\x based on a Hit, including ( i ) any structure based on the structure of a Hit ( or anyone of the active substructures, ifmore than one exist ), ( ii ) any structure based on activity data derived ITom a Hit, ( iii ) a chemical derivative of either a Hit, or a Development Candidate or ( iv ) any molecule with a structure that falls within the scope of any Valid Claim owned, licensed or Corllrolled by [COMPANY] that encompasses a HiU It is understood that shall include any compound derIVed ITom another Denvau~ 1.17 shall mean t ; Hit or Derivative that is used in ( i ) a medicinal chemistry program for lead optimization in respect theG1bY or for [COMPANY], or ( ii ) in vivo testing in non - human animals for activity or safety by or for [COMPANY]