definiens: means [COMPANY] ’ proprietary tools, processes and methods forProtein Engineering that are covered or claimed by Patents or Know - How Controlled by [COMPANY], including without limitation ( i ) tools, processes and methods used to identify, select, optimize, isolate, modify, engineer and develop proteins, including enzymes, through the recombination, rearrangement and/or mutation of genetic material for the creation of genetic diversity using anymethods, including but not limited to bioinformatics, in silico, in vitro, and/or in vivo technologies,(ii ) screening techniques, methodologies and/or processes of using the resulting genes and / orproteins, including enzymes, to identify and assess their potential utility, ( iii ) gene expressionmethods applicable in high throughput screening, ( iv ) techniques for cultivation ofmicroorganisms, ( v ) techniques for producing, harvesting, and/or purifying proteins, includingenzymes, and ( vi ) bioinformatics methods and algorithms, including those known as,,, and ( in each case ( clauses ( i ) through ( vi ), for clarity, as used in Protein Engineering ) ; provided however that [COMPANY] Methods shall not include anyInformation, tools, processes or methods that are specifically related to, or are otherwisenecessary for the Exploitation of, a Compound, Product, ROFN Compound or ROFN Product, asapplicable