definiens: means, with respect to an Ant ibody, ( a ) the fragments and alternate formats of t he immunoglobulin molecule of such Antibody such as Fa b, Fab2, scFVs, nanobodies, intrabodies, diabodies, ( b ) mono- or multi - specific and mono- or multi - valent i mmunoglobulin molecules arising from fusions or oth er modifications of or to such Antibody, in each of th e foregoing cases ( ( a ) and ( b ) ) that specifically b inds to the Target and ( c ) any immunoglobulin molecule ( includi ng any fragments and alternative formats thereof, s uch as Fab, Fab2, scFVs, nanobodies, intrabodies, diabodie s, and mono- or multi - specific and mono- or multi - v alent immunoglobulin molecules arising from fusions or ot her modifications of or to such immunoglobulin mole cule ) that comprises any modification to a CDR of such An tibody that results in greater than eighty percent ( 80 % ) sequence identity relative to the original CDR of s uch Antibody prior to the modification ( such CDR se quence identity determined by the Clustal W software progr am, Version clustalw1.83, January 30, 2003, set to default settings, or such other similar software program as may be mutually agreed upon by the Parties ) and bi nds to the Target, as evidenced for purposes of this clause ( c ) by the ability of such immunoglobulin molecule to inhibit binding of the original unmodified Antibody to the Target by at least seventy percent ( 70 % ) in assays conducted in each of the following orientations : ( x ) unmodifi ed Antibody immobilized and such immunoglobulin mol ecule is in solution and ( y ) such immunoglobulin molecule is immobilized and the unmodified Antibody is in s olution