definiens: means any change, event or occurrence that, individually or in theaggregate with all other such changes, events or occurrences or developments, has had, or would reasonably beexpected to have, a material adverse effect on or change in the assets, business, results of operations or condition(financial or otherwise ) of the Product Business, taken as a whole ; provided, however, that the term does not, and shall not be deemed to, include any of the following : ( i ) changes or effects that generally affectthe industry or industries in which the Product Business operates [ * ] ; ( ii ) changes in securities markets, interest ratesor general economic, regulatory or political conditions, including acts of terrorism or the commencement or escalationof any war, whether declared or undeclared, or other hostilities ; ( iii ) changes or effects arising out of, or attributable to, the announcement of the execution of this Agreement ; ( iv ) changes or effects due to changes ( or proposed orprospective changes ) in any Laws affecting the Product Business or the Transferred Assets ; ( v ) changes in GAAP, IFRS or other applicable accounting regulations and principles or the interpretation thereof ; or ( vi ) [ * ]