definiens: will be construed accordingly . 1.50 means, with respect to CASI ’s obligations under this Agreement that relate to any Licensed Compound or Licensed Product, the level of efforts as required to carry out a task in a diligent and sustained manner without undue interruption, pause or delay, which level is at least commensurate with the level of efforts that a similarly situated biopharmaceutical company of similar size and resources would reasonably devote to a product of similar market potential at a similar stage in development or product life cycle and h aving similar commercial and scientific advantages and disadvantages, when utilizing sound and reasonable scientific, medical, and business practice and judgment in order to Develop such Licensed Compound or Licensed Product, based on conditions then preva iling and taking into account all relevant factors, including ( a ) issues of safety, tolerability, and efficacy, ( b ) product profile, ( c ) difficulty in and costs of Developing or Manufacturing any Licensed Compound or Licensed Product, ( d ) competitiveness o f any Licensed Compound or Licensed Product and alternative therapies in the marketplace, ( e ) the nature and extent of market exclusivity, ( f ) the patent or other proprietary position of any Licensed Compound or Licensed Product, ( g ) Third Party intellectu al property rights, ( h ) the regulatory structure involved, ( i ) the potential profitability of any Licensed Compound or Licensed Product, taking into account anticipated and actual Development costs and expenses, and ( j ) anticipated or actual product labeli ng . It is anticipated that the level of effort will change over time, reflecting changes in the status of such Licensed Product and the market or country involved