definiens: means such level of efforts required to carry out such obligation in a sustained manner consistent with the efforts that R oche devotes at the same stage of development or commercialization, as applicable, for its own inter nally developed pharmaceutical products in a simila r area with similar market potential, at a similar stage of the ir product life taking into account the existence o f other competitive products in the market place or under d evelopment, the proprietary position of the product, the regulatory structure involved, the anticipated prof itability of the product and other relevant factors . It is understood that such product potential may change f rom time to time based upon changing scientific, bu siness and marketing and return on investment consideratio ns . The parties acknowledge that Roche ( and its Aff iliates ) does not always seek to market its own products in every country or seek to obtain regulatory approval in every country or for every potential indication . [ * * * ] [ * * * ] Certain information in this document has been omitted and filed separately with the Securities a nd Exchange Commission . Confidential treatment has bee n requested with respect to the omitted portions