definiens: means any and all of : ( A)(I ) ( + ) -alpha - Methylbenz eneethanamine, also known as, ( II ) carbamazepine ( 5H -Dibenz{b, f}azepine-5 - carboxyamide ), ( III ) guanfacine ( N-(Aminoiminomethyl)-2,6 - dichloro benzeneacetamide ), ( IV ) lanthanum, and ( V ) mesalamine ( 5 - Amino-2 - hydroxybenzoic acid ), ( B ) any isomers, salts, solvates, hydrates, polymorphs, esters, prodrugs, or metabolites of cla use ( A ), and ( C ) any compound involving forming or breaking a bond or bonds with any of cla use ( A ) or ( B ) where at least one prophylactic, therapeutic or diagnostic indication of such compound and/or its metabolite is substantially the same as that of any of clause ( A ) or ( B ), but excluding 10,11 - Dihydro-10 - oxo-5H - debenz[b, f]azepine-5 - carboxamide, also known as