definiens: means a Product based on another Product, where there has been a change in'the molecular sequence of such other Product,'whether of the Gene . any promoter, the vector, or otherwise, where such change is not so significant as to create a different Product, as d ~ tennined by Committee Action consistent with this Section . By way of illustration, but not limitation as to other situations : ( i ) the use of~'different phenotype of AAV Vecto~ ( where the initial Product ' * ' incorporated an AA V Vector ) would lead to a Modified Product and not a different Product ; ( ii ) the use of any AA V Vector where the initial Product incorporated an Ad Vector ( and vice versa ) would lead to a different Product and not a Modified Product ; DOC'SPNWI : 3880.1 O - Gn-':K -11- * Confidential T ~ atment Requested ( iii ) a change in the sequence of a Gene which nevertheless retains a homologous sequence to the initi3I Gene sequence, expressing essentially the same protein or its homologue, would lead to a Modified Product and not a different Product ;