definiens: means such application of effort and resources by the relevant Party as would be consistent with its actions in respect of a product or compound Controlled by such Party, which is of similar market potential · and at a similar stage in its development or product life, taking into account, without limitation, with respect to a product, issues of safety and efficacy, product profile, the proprietary position of the product, the then current competitive environment for the product and the likely timing of the product 's entry into the market, the regulatory environment of the product, and other relevant scientific, technical and commercial factors, but explicitly not taking into account any financial obligations that would be owed to Pacira under this Agreement . For Novo Nordisk, Commercially Reasonable Efforts may also take into account that Novo Nordisk has internal development projects for lQJ;l.& .. ~JJ·Il&.JlYJmW GLP - I analogues intended for once - weekly administration . Notwithstanding the foregoing, to the extent that the performance of a Partis responsibilities hereunder is adversely affected by the other Party 's failure to perform its responsibilities hereunder, such Party will not be deemed to have failed to use its Commercially Reasonable Efforts in performing such responsibilities