definiens: shall mean any pharmaceutically active agent which a ) In s nuc eic adds'aslliey exist in ~a·cell : an(f(6rconsrsts ' o(nuaeic -acia -of~:illJnctional analog, derivative or homolog thereof, and ( c ) is complementary to a segment of DNA I of a given Disease Gene, or such Disease Gene 's transcribed RNA or a gene that ! encodes another member of the Biological Pathway of which the product of such Disease Gene is a member, and ( d ) upon delivery by any means, compensates, either completely or partially, for the genetic defect that underlies the Selected Disease the a enesis of which is affected by the Disease Gene, an e IS conceive an reduced to prac Ice as a resu t 0 a esearc Program by a Party, its Affiliate or its ~ollaborator at any time during a period commencins ~n the Effective Date and eJ1di ~ g five ( 5 ) years after the date a first Validated Target was obtained for the Selected Disease the pathogenesis of which is affected by the Dis ~ ase Gene :