definiens: , as used in this Agreement, shall mean all information, manufacturing techniques, data, designs, methods or concepts ( whether or not such specific information, manufacturing techniques, data, designs, or concepts are or become publicly known or available ) covering the introduction of recombinant nucleic acid products into cells of the vasculature by catheterization and other gene therapy approaches, developed by MICHIGAN 's employees Dr. Elizabeth G. Nabel and Dr. Gary J. Nabel, as described in MICHIGAN 's Intellectual Properties Office File No . 356 entitled and encompassing the following patent applications : U.S : Patent Application Serial No . 07/724,509 entitled " Treatment of Diseases by Site - Specific Instillation of Cells or Site - Specific Transformation of Cells and Kits Therefor, Treatment of Diseases by Site - Specific - Instillation of Cells and Kits Therefor, " and Japanese Patent Application Serial No . 505562/90 based upon the abandoned U.S. Patent Application Serial No . 07/331,366 entitled " Treatment of Diseases by Site - Specific Instillation of Cells or Site­Specific Transformation of Cells and Kits Therefor "