definiens: means, with respect to a given Global Monotherapy Trial, the sum of the following : ( a ) [ … * * * … ], ( b ) [ … * * * … ] and ( c ) [ … * * * … ], in each case ( clauses ( a ) through ( c ) ) incurred by a Party or its Aﬃliate from time totime after such time as such Global Monotherapy Trial is commenced in accordance with the Additional Global DevelopmentPlan and that are reasonably allocable to the conduct of such Global Monotherapy Trial in accordance with the AdditionalGlobal Development Plan . For purposes of this deﬁnition, ( i ) [ … * * * … ] means [ … * * * … ] ; ( ii ) [ … * * * … ] means [ … * * * … ] ; ( iii ) [ … * * * … ] means [ … * * * … ] ; ( iv ) [ … * * * … ] means a rate of $ [ … * * * … ] per annum during Calendar Year 2021, such amount to beadjusted as of January 1, 2022 and annually thereafter by [ … * * * … ]