definiens: means any development, enhancement, improvement, invention, modification, or derivative ( whether or not patentable ) necessary for or actually applied to the Manufacture of QS-21 that is made, discovered, conceived or reduced to practice by or on behalf of [COMPANY] or its Affiliates in the course of the furtherdevelopment or Manufacturing of QS-21 at any time during the term of the [ * * ], or the [ * * ] of this Agreement or byAntigenics MA or its Affiliates in the course of the further development or Manufacture of QS-21 at any time during theterm of the [ * * ], or the [ * * ] of this Agreement . For the avoidance of doubt, Manufacturing Improvements specificallyexclude any development, enhancement, improvement, invention, modification, or derivative ( whether or notpatentable ) relating to [ * * ] ( as opposed to [ * * ] ) or [ * * ] or [ * * ] or [ * * ] of [ * * ] with a [ * * ] other [ * * ] or any other [ * * ] of a [ * * ]