definiens: means, with re spect to the Early Discovery Business, taken as a whole, any event, change or effect that, when taken individually or together with all other adverse events, changes and effects, ( a ) is or would reasonably be expected to be materially adverse to the financ ial condition, assets, business or operations of the Early Discovery Business, taken as a whole or ( b ) would prevent or materially delay consummation of the Transactions ; provided, however, that, with respect to clause ( a ) above, any events, changes or eff ects will not be deemed to constitute a Material Adverse Effect to the extent resulting from ( i ) general changes or conditions in general economic, political or market conditions or in the industries ( or therapeutic areas ) in which the Early Discovery Busi ness operates ; ( ii ) any failure by Seller or the Early Discovery Business to meet internal projections or forecasts for any period ( provided that the underlying causes of such failure may be taken into account in determining whether there has been a Materi al Adverse Effect ) ; ( iii ) acts of war or terrorism ( or the escalation of the foregoing ) or natural disasters or other similar force majeure events ; ( iv ) changes in any Legal Requirements applicable to the Early Discovery Business or applicable accounting r egulations or principles or the interpretation thereof ; ( v ) compliance by Seller or any of its Affiliates with an express written request by Purchaser that Seller or any of its Affiliates take an action ( or refrain from taking an action ) to the extent such action or inaction is in compliance with such request ; ( vi ) any action taken by Seller or any of its Affiliates as required by this Agreement ; provided, that, with respect clauses ( i ), ( iii ) or ( iv ) only to the extent that such event, change or effect does not have a materially disproportionate effect on the Early Discovery Business, taken as a whole, compared with other companies or businesses operating in such industries ( or therapeutic areas )