definiens: means, with respect to the activities of ILDONG, and/or its Affiliates, Sublicensees, Distributors, in the Development or Commercialization, as the case may be, of a particular Compound and / orProduct, the level of efforts and resources typically used and expected from a pharmaceutical company of similar size for thedevelopment or commercialization of products of comparable market potential, taking into account all relevant factorsincluding, as applicable, the stage of development, observed efficacy and safety of the Product and relative to CompetitiveProducts in the marketplace, actual or anticipated Regulatory Authority approved labeling, the nature and extent of marketexclusivity ( including patent coverage, regulatory exclusivity and competitiveness of alternative products ), the cost andlikelihood of obtaining Marketing Authorization, the actual or projected profitability, and the reasonably expected and actualpricing, reimbursement and formulary status . For purposes of clarity, Commercially Reasonable Efforts shall be determined ona market - by - market and Indication - by - Indication basis for a particular Compound and/or Product, and it is anticipated that thelevel of effort may be different for different markets and may change over time, reflecting changes in the status of theCompound or Product and the market(s ) involved