definiens: shall mean collectively ( a ) United States Patent Application Serial No . 09/963,827entitled filed September 26, 2001 ( Office of Science andTechnology Combined File # 1708 composed of Office of Science and Technology Files # 1708, 1709, 1710,1839, and 1855 ) but expressly excluding all references and all claims as they relate to Ang 1, including, withoutlimitation claims 57 through 67 ( inclusive ), as they relate to Ang1 ; ( b ) United States Patent Application SerialNumber 10/155,233 entitled filed May 28, 2002 ( Office of Science andTechnology File # 1897 ) and claiming priority from United States Provisional Patent Application for filed May 25, 2001 ( Office of Science and Technology File # 1897 ) and United StatesProvisional Patent Application for filed November 17, 2001 ( Office ofScience and Technology File # 1897 ) ( hereinafter, the patent applications identified in the preceding ( a ) and(b ) may be referred to individually or collectively as ) ; ( c ) allsubstitutes, -2- continuations, continuations - in - part ( but only to the extent that the subject matter of each such continuation - in - part application is described in and enabled by the disclosure of the INITIAL DUKE PATENT APPLICATIONS),and divisionals of the foregoing applications ; ( d ) all foreign patent applications corresponding to the foregoingU.S. applications ; ( hereinafter, the patent application identified in the preceding ( a)—(d ) may be referred toindividually or collectively as ) ; and ( e ) all U.S. and foreign patents issued orissuing with respect to any of the foregoing applications, and all extensions, renewals, reissues thereof