definiens: mean s ( i ) with respect to Schering, that degree of skill, effort, expertise, and resources normally used by an established pharmaceutical company and ( ii ) w ith respect to PTC, that degree of skill, effort, expertise, and resources n ormally used by an established biotechnology company, in each case wit h respect to a pharmaceutical product which is of similar market potential at a s imilar stage in its product life, taking into account the safety and efficacy o f the compound or product, the cost to Develop and Commercialize the product, the risks inherent in the Development and Commercialization of the product, t he competitiveness of the marketplace, the proprietary position of the compou nd or product, the likelihood of obtaining Regulatory Approval for the product, t he potential economic 2 EXECUTION VERSION return from the applicable product, and other techn ical, legal, scientific, medical or commercial factors that such Party deems in good faith to be relevant