definiens: means ( 1 ) licenses granted by Isis before or after the Effective Date to any Third Party underthe Isis Core Technology Patents, the Isis Manufacturing and Analytical Patents, or the Isis Manufacturing andAnalytical Know - How ( but not under the Isis Product - Specific Patents ) to ( a ) use oligonucleotides ( or supplyoligonucleotides to end users ) solely to conduct pre - clinical research, or ( b ) enable such Third Party to manufacture orformulate oligonucleotides, where ( i ) such Third Party is primarily engaged in providing contract manufacturing orservices and is not primarily engaged in drug discovery, development or commercialization of therapeutics ; and ( ii)Isis does not assist such Third Party to identify, discover or make a Compound or Product ; and ( 2 ) material transfer, collaboration or sponsored research agreements with academic collaborators or non - profit institutions solely toconduct noncommercial research