definiens: . Commercially Reasonable Efforts means the efforts required in order to carryout a task in a diligent and sustained manner without undue interruption, pause or delay ; which level is at least commensuratewith the level of efforts and investment that a biopharmaceutical company would devote to an oncology product at a similardevelopment stage or product life, having similar market potential and having similar commercial and scientific advantagesand disadvantages based on conditions then prevailing, explicitly ignoring the royalty, milestone and all other payments dueAVEO under this Agreement, and taking into account, without limitation, the safety and efficacy of such product, regulatoryauthority - approved labeling, product profile, the competitiveness of alternative products, its proprietary position, pricing, reimbursement and other market - specific factors, the likelihood of regulatory approval, the likely timing of the product’sentry into the market, and all other relevant factors . Commercially Reasonable Efforts requires ( without limitation ) that theParty exerting such efforts ( a ) promptly assign responsibility for its obligations to specific employee(s ) who are heldaccountable for progress and monitor such progress, on an ongoing basis, ( b ) set and continue to seek to achieve specific andmeaningful performance objectives for carrying out such obligations, and ( c ) make and implement decisions and allocateresources designed to advance progress with respect to such performance objectives, in each case in a commercially reasonablemanner