definiens: shall mean the following compassionate use indications which, as of the Effective Date, are in cluded in one or more of [COMPANY] ’s active INDs f or the Compound : 3 ( a ) Acute myocarditis of presumptive picornaviral origi n, ( b ) Acute or progressive encephalitis of presumptive pi cornaviral origin, ( c ) Neonatal sepsis of presumptive picornaviral origin, ( d ) Evidence of presumptive picornaviral infection in t he presence of a primary or secondary immune deficient disorder ( e.g., Brutons X - linked agammagl obulinemia, severe combined immune deficiency, hyper IgM, hypogammaglobulinemia, commo n variable immune deficiency, bone marrow or organ transplant recipients ), and ( e ) VAPP, wild -type paralytic poliomyelitis, or other paralytic il lness of picornaviral origin