definiens: means all activities directed to the Development, Manufacture and/or Commercialization ofProducts for the Territory performed after the Original Effective Date, during the period from the Original Effective Date to theFirst Restated Effective Date, and during the period from the First Restated Effective Date to the Second Restated EffectiveDate, by or on behalf of Amicus ( or its Affiliates or Sublicensees ) and/or [COMPANY] ( or its Affiliates or sublicensees ) under theOriginal Agreement or the First Restated Agreement, as applicable ; provided, however, it is understood that all activities thatare ( a ) related to the Development of Products conducted either by Amicus or [COMPANY] prior to the Original Effective Date, or(b ) related to the Manufacture of JR051, or ( c ) related to the [COMPANY] Route B Manufacturing Process, will be deemed to havebeen conducted outside of the Program