definiens: shall mean the amount invoiced by [COMPANY], its Affiliates or Sublicensees for Sales of the License d Product less the following deductions, but only to the extent that the amounts sought to be deducted are part of the total invoiced amount : ( a ) discounts, r eturns, allowances, commissions and wholesaler chargebacks allowed and taken ; ( b ) import, export, excise, sales or use taxes, value added taxes, and other taxes, tariffs and duties imposed on such Sales ; ( c ) freight, freight insurance, packaging, handling, transportation and other insurance relati ng to such Sales ; and ( d ) amounts allowed or credited on such Sales for retro active price reductions or rebates including, but not limited to, Medicaid reb ates . [COMPANY], may, at its option, allocate the above deductions from Sale s of the Licensed Product based upon accruals estimated reasonably and consis tent with [COMPANY] ' standard business practices, and in any event in ac cordance with generally accepted accounting principles applied on a consist ent basis, provided, further, that such deductions are of a type ( such as Medicai d rebates ) the actual amounts of which can not reasonably be determined at the tim e royalties on the related Net Sales are due under this Agreement . If PathoGen esis elects to utilize such accruals, actual deductions will be calculated and, if applicable, a made, on an annual basis . If the Licensed Product c ontains, in addition to the Compound, one other therapeutically active ingredie nt, Net Sales shall be deemed to be [ * * * * * * * * ] % of the Net Sales of such Licensed Product . If the Licensed Product contains, in addition to the Compound, two or more other therapeutically active ingredients, Net Sales shall be deemed to be [ * * * * * * * * ] % of the Net Sales of such Licensed Product . If the Licensed Product i s sold in combination with any Inhalation Device, Net Sales shall be deemed to be the Net Sales of the combination of the Licensed Product and such Inhala tion Device multiplied by the fraction [ * * * * * * * * ] . If either the Licensed Product or the Inhalation Device is not sold separately, or if the fraction is less tha n [ * * * * * * * * ], Net Sales shall be deemed to be [ * * * * * * * * ] % of the Net Sales of the combination of the Licensed Product and such Inhalation Device