definiens: shall mean the le vel of efforts and resources which would be used by the Buyer with regard to the development of pharmac eutical products of similar market and profit poten tial at a similar stage in development or product lifecy cle, taking into consideration the safety and effic acy of the product, anticipated or approved labeling for t he product, the risks inherent in the development a nd commercialization of the product, the product ’s com petitiveness compared to alternative products in th e marketplace, the proprietary position of the produc t ( including scope and duration of relevant patents ), the regulatory status of the product, whether the produ ct is subject to a clinical hold, recall or market withdrawal, the likelihood of receipt of Marketing Authorization in a particular jurisdiction, the ant icipated profitability of the product ( including the amounts payable to licensors of patents or other intellect ual property rights necessary to sell the product in th e relevant market ) and other relevant factors commo nly considered by the Buyer and its Affiliates in conne ction with comparable products . Commercially Reasonable Efforts shall be determined on a market- by - market basis for a particular product and the le vel of effort may be different for different markets, a nd it is anticipated that the level of effort will change over time, reflecting changes in the status of the produ ct and the market involved . It is understood that a delay or cessation of efforts to develop or commercialize a product may be consistent with Commercially Reasonable Efforts