definiens: means, with respect to Licensee and its obligations under this Agreement, commercially reasonable effor ts and resources as commonly used by a similar size pharmaceutical company to Develop and Commercialize a product controlled by Licensee or to which it ha s exclusive rights, which product is at similar stage in its development or product life and is of simil ar market potential taking into account efficacy, safety, app roved and/or anticipated labelling, the competitive ness of alternative products sold by Third Parties in the m arketplace, the patent and other proprietary positi on of the product, likelihood of regulatory approval given th e regulatory structure involved, the profitability of the product, [ * * * ] and other relevant factors, including technic al, legal, scientific and/or medical factors . Comme rcially Reasonable Efforts shall be determined on a country -by - country basis and indication - by - indication basi s for a particular Product, and it is anticipated that the level of effort will change over the time, reflecti ng changes in the status of the Product and the country(s ) involved . [ * * * ]