definiens: shall mean all external costs and direct internal costs incurred by Metasyn or MKG in connection with the Research Program phiS indirect costs allocated to the Research Program pursuant to the terms agreed to by the Panies, as more fully described in Appendix IV hereto . Research Costs shall specifically not include any such costs to the extent attributable to ' research in connection with any compounds and their corresponding Licensed Products to be utilized, sold or distributed exclusively in Japan, it being understood that such costs shall be entirely the responsibility and liability of Metasyn and/or DRL ; provided, however, that if DRL is not granted a license in accordance with Section 2.4.1 hereof with respect to any compound for Japan prior to the IND filing with the FDA for such compound by the Panies, the Research Costs shall include all such costs relative to any such compound for all purposes hereof . Costs for Licensed Products or Compounds that are to be sold or distributed on a worldwide basis ( including any Gase where such Licensed Products or Compounds are licensed to DRL in accordance with Section 2.4.1 hereof prior to the filing of an IND with the F~ ) will be apportioned to the Panies to reflect the fact that Japan represent ~ e - thir ~ fThe worldwide market for such Licensed Products or Compounds