definiens: mean ( a ) a US and corresponding foreign patent application ( including provisional application, division, refiling, continuation, continuation - in - part, reissue and reexamination thereof ) ; and ( b ) any patent ( including without limitation, any substitution, extension, reissue, renewal, reexamination, patent of addition, supplementary protection certificate and inventors ’ certificate ) that has issued or may issue in thefuture from any patent application described in Subsection ( a)1.46 means any product ( including without limitation any GS Products ) researched, developed and/or commercialized byLicensee that contains a protein produced using the Formulation Know - How, the PFM System, the Protein - Free Know - How and/or ProteinFree Patents, including without limitation PFM Know - How Products and PFM Patent Products, but excluding the use of any modification byLicensee to the Formulation Know - How