definiens: means Orphan Receptor(s ) in the possession of [COMPANY] prior to the Effective Date, or acquired by [COMPANY] after the Effective Date, or publicly available, and for which [COMPANY] knows and simultaneously transfers to Arena : ( i ) the nucleic acid sequence thereof ; ( ii ) the amino acid sequence thereof ; ( iii ) the predominant G protein form that couples to the intracellular region(s ) of the Orphan 2 < PAGE > 4 Receptor, and ( iv ) the nucleic acid sequence in an expression and/or shuttle vector which can be expressed as a functional protein using a commercially available mammalian cellular expression system ; excludes ( i ) any Orphan Receptor that was in the possession of Arena and 7/21/2016 https://www.sec.gov/Archives/edgar/data/1080709/000089256900000447/ex10­12.txthttps://www.sec.gov/Archives/edgar/data/1080709/000089256900000447/ex10­12.txt 4/15subjected to the Arena Activation Technology prior to the Effective Date ; ( ii ) any Activated Orphan Receptor existing prior to the Effective Date ; or ( iii ) any Orphan Receptor or Activated Orphan Receptor that is the subject of collaborative or licensing activities between Arena and any Third Party and/or Arena Collaborator