definiens: means, with respect to each Exclusivity Compound, ( i ) all Related Compounds which represent any ester, salt, crystalline polymorph, hydrate or solvate of such Exclusivity Compound or that have substantially the same Mechanism of Action as such Exclusivity Compound at the Protein Target Profile for such Exclusivity Compound 's Program and ( ii ) after the exercise by [COMPANY] of its Program Option for such Exclusivity Compound 's Program, all other Collaboration Compounds in such Program ( A ) for which exploratory toxicology studies were contracted for by [COMPANY], were commenced or were completed, in each case as of the date of exercise by [COMPANY] of such Program Option, or ( 8) that first met the Lead Criteria more than twel ve ( 12 ) months prior to the date of exercise by GS K of such Program Option and all Related Compounds with respect to the Collaboration Compounds described in clause ( ii ) above which represent any ester, salt, crystalline polymorph, hydrate or solvate thereof or that have substantially the same Mechanism of Action as such Collaboration Compounds at the applicable Protein Target Profile