definiens: shall mean ex vivo Gene therapy for human disorders limited to adrenoleukodystophy ( ALD ) ( including but not limited to AMN, CCALD, and all other variants of this disease caused by genetic mutations ), beta hemoglobinopathies ( including but not limited to beta - thalassemia and sickle cell anemia ), ( hemophilia, lysosomal stonge disorders ( LSDs, including Gaucher disease, Fabry disease, Pompe disease or GAA deficiency, and mucopolysaccharidos is I, II and VI ), HIV / AIDS, lleukemias, lymphomas, 8 - cell malignancies and solid tumors by producing chimeric antigen receptor T - cells Ithat target specific tumor antigens ( TSA ), including those TSA that are specific to 8 cell malignancies and solid tumors and are present only on lumor cells and not on any other cell, andlor tumor - associated antigens which are present on some tumor cells and also some normal cells, autoimmune diseases, eye diseases ( including but not limited to AMD and Slargardt disease ), and Parkinson 's Diseasel ; for [ Parkinson 's Disease, ) and ( eye diseases ( including but Dol limited to AMD and Stargardt disease ) . ) the includes in vivo as well as ex vivo Gene therapy . IUcensee andlor Affiliates shan have the right to request Institut Pasteur to upand the definition or the to include additional clinical areas . To expand the Field, Licensee andlor Affiliates shan provide written notification to Institut Pasteur that it or any or its Affiliates or sublicensees has initialed a program in such area(s ) . Ir Institut Pasteur does noi object, the Parties shall execute a formal amendment to the Agreement within sixty ( 60 ) days thereafter . No rurther consideration shall be due to Institut Pasteur for the expanded Field . ) • For clarity, the Field excludes : ( i ) any other fields and specifically [ prophylactic and theraptutic human and veterinary Vaccination againsl all lUnd or pathogens or pathology I and ( ii ) the making, using, selling or offering for sale, and importation of [ research reagents incorporating Technologyj, and provision of services relating to the same