definiens: means ( 1 ) licenses granted by Isis before and aft er the Effective Date to any Third Party underthe Isis Core Technology Patents, the Isis Manufact uring and Analytical Patents, or the Isis Manufactu ring andAnalytical Know - How ( but not under the Isis Product -Specific Patents ) to ( a ) use oligonucleotides ( or supplyoligonucleotides to end users ) in quantities not to exceed [ * * * ] per oligonucleotide per end user sole ly to conduct Pre - Clinical Research, or ( b ) enable such Third Party t o broadly manufacture or formulate oligonucleotides, where suchThird Party is primarily engaged in providing contr act manufacturing or services and is not engaged in drug discovery, development or commercialization ; and ( 2 ) material transfer agreement with academic collaborators or n on - profitinstitutions to conduct noncommercial research on g ene targets