definiens: means and includes : The De velopment Alliance and Supply Agreement dated May 7, 2002 between Biosense and [COMPANY] ( the ), as amended by : ( i ) the Amendment to Development and CONFIDENTIAL Supply Agreement dated November 3, 2003 ( the ) ; ( ii ) the research and development side letter between the Parties dated N ovember 3, 2003, ( the ) ; ( iii ) the Alliance Expansion Agreement dated May 4, 2007 ( ) ; ( iv ) four side letters between the Parties, each dated May 4, 2007, whose subject matter was, respectively, CARTO Pro RMT, Third Party Collaboration Rights, Exclusivity and the Meaning of Customers in the Non - Localized Alliance ( collectively, the ) ; ( v ) the Second Amendment to Development Alliance and Supply Agreement, dated July 18, 2008 ( the ) ; ( vi ) the Third Amendment to Development Alliance and Supply Agreem ent, dated December 8, 2009 ( the ) ; ( vii ) the Fourth Amendment to Developm ent Alliance and Supply Agreement, effective as of May 1, 2010 ( ) ; ( viii ) the Fifth Amendment to Development Alliance and Supply Agreement, effective as of August 1, 2010 ( ) ; and ( ix ) the Sixth Amendment and Catheter and Mapping System Extension to Development Alliance and Supply Agreement, dated December 17, 2010 ( )