definiens: means each written document developed and approved by the SteeringCommittee in accordance with Section 5(a)(ii ) of this Agreement setting forth a detailed description of theResearch to be performed in the conduct of the Project . The Detailed Project Description ( the ) covering the twelve - month period beginning July 1, 2011 for the Project isattached to this Agreement as Appendix B . With respect to the Initial Detailed Project Description, theParties agree that ( i ) the activities specified therein to be conducted during the six - month period beginningJuly 1, 2011 ( except for any such activities specifically identified as requiring subsequent approval by theSteering Committee ) are firm and agreed to in detail by Isis and the Foundation and ( ii ) the activitiesspecified therein to be conducted during the six - month period beginning January 1, 2012 have been listedfor planning purposes and are therefore estimated and agreed to by the Parties in concept ; those activities aresubject to further approval of the Steering Committee in accordance with this Agreement prior to theirconduct by Isis