definiens: shall mean shall mean the practice, production, manufacture, sale and use of the Licensed Rights for the discovery, development and commercialization of methods, techniques, devices, systems, animals and therapeuti cs in the field of regulating cell death : Page 22 of 30 ( i ) CBLC100 series : small molecules that restore the activity of p53 tumor suppressor in cancers, including renal cell carcinomas, sarcomas, prostate cancers and other types of malignancies ; curax ines and derivatives thereof are representative examples of this category ; ( ii ) CBLB101 series : substances of biological nature ( i.e., cytokines, chemokines and other secreted molecules ) and their bioactive derivatives produced by tumor cells and capable of modulating cell survival ; TGFβ2 and derivatives thereof and derivatives thereof are representative examples of this category ; ( iii ) CBLB501 series : natural factors produced by extracellular parasites and symbionts of humans and other mammalian specie s and their bioactive derivatives capable of modulating cell survival mechanisms of host cells ; flagellin of Salmonella typhimurium and derivatives thereof are representative examples of this category ; ( iv ) CBLC500 series : small molecules modulating tumor and normal cell sensitivity to cytotoxic chemicals by altering activity and substrate specificity of multidrug transporters ; inhibitors of MRP1 and derivatives thereof are representative examples of this category