definiens: shall mean : ( i ) the composition of PEG reagents ( including the REAGENT);(ii ) methods of using PEG reagents ( including the REAGENT ) by themselves or in combination with other PEG reagents orother substances ; ( iii ) methods of making, processing, analyzing or characterizing PEG reagents ( including the REAGENT);(iv ) methods of attaching one or more PEG reagents ( including the REAGENT ) to Page 4 of 48or associating one or more PEG reagents ( including the REAGENT ) with or to any therapeutic agent ( including theTHERAPEUTIC AGENT ) ; ( v ) methods of directing or determining the point of attachment of one or more PEG reagents(including the REAGENT ) to or associating one or more PEG reagents ( including the REAGENT ) with any therapeutic agent(including the THERAPEUTIC AGENT ) ; ( vi ) the composition or formulation of any product ( other than the PRODUCT)obtained by attaching or associating one or more PEG reagents ( including the REAGENT and including by PEGYLATION ) toor with any therapeutic agent ( excluding PEGYLATION of the THERAPEUTIC AGENT with the REAGENT ) ; and(vi ) methods of making, formulating, combining, processing, using, analyzing or characterizing two ( 2 ) or more PEG reagents(including the REAGENT ) in combination