definiens: means ( a ) in the case of the applicable Development activity described hereunder, as of theEffective Date, [ * * * ] Dollars ( $ [ * * * ] ) per FTE, ( b ) in the case of all activities hereunder for which costs are shared underthe [ * * * ] a rate which is reasonably established by [ * * * ] in advance of the [ * * * ], and ( c ) in the case of all activitieshereunder for which costs are shared under the [ * * * ] a rate which is reasonably established by [ * * * ] in advance of the [ * * * ] ; provided that in the case of clauses ( b ) and ( c ), a separate FTE Rate shall be established for each of thefollowing categories ( and in each case such rate shall include the allocable management costs for such positions):sales force personnel and associated support personnel, marketing, market research / survey, market access, marketing effectiveness, managed care and account management, pricing, product communication and digitalcommunication, health economics, medical liaisons, health outcome liaisons, regulatory, pharmacovigilance, medicalaffairs ; and provided further that in each case ( ( a ), ( b ) and ( c ) ) such rates shall be adjusted annually, with each annualadjustment effective as of January 1 of each Calendar Year, with the first such annual adjustment to be made as ofJanuary 1, 2016, to correspond with the total percentage change in the Producer Price Index ( PPI ) for Pharmaceuticaland Medicine Manufacturing ( NAICS 325400 ) for the twelve ( 12)-month period preceding each such January 1 ; andprovided further with respect to the activities described in clauses ( b ) and ( c ), every [ * * * ] that the FTE Rates thereforare in effect, the Parties may mutually agree to revise such rates . For clarity, the [COMPANY] Research Activities andSanofi POC Activities shall be valued using the applicable FTE Rate