definiens: means : ( i ) the com position of REAGENTS ( including SELECTED REAGENT ) by themselves ; ( ii ) methods of us ing REAGENTS ( including SELECTED REAGENT ) by themselves or in combination ; ( iii ) met hods of making, processing, analyzing or characterizing REAGENTS ( including SELECTED REAGENT ) ; ( iv ) methods of attaching one or more REAGENTS ( including SELECTED REAGENT ) to or as sociating one or more REAGENTS ( including SELECTED REAGENT ) with or to any therape utic agent ( including the THERAPEUTIC AGENT ) ; ( v ) methods of directing or determining the point of attachment of one or more REAGENTS ( including SELECTED REAGENT ) to or associa ting one or more REAGENTS ( including SELECTED REAGENT ) with or to any therape utic agent ( including the THERAPEUTIC AGENT ) ; ( vi ) the composition of any product ( exclud ing SELECTED PRODUCT ) obtained by attaching or associating one or more REAGENTS ( incl uding by PEGYLATION and including SELECTED REAGENT ) to or with any therapeutic agent ; and ( vii ) methods of making, formulating, combining, processing, using, analyzing or characte rizing two ( 2 ) or more REAGENTS ( including SELECTED REAGENT ) in combination