definiens: shall mean, with respect to the Product Lines, taken as a whole, any event, change or effect that, when taken individual ly or together with all other adverse events, chang es and effects, ( a ) is or would be reasonably expected to be materially adverse to the Purchased Assets, Assu med Liabilities, Product Lines or the financial or othe r condition, assets, business or operations of the Product Lines, taken as a whole, or ( b ) would or would be reasonab ly expected to prevent or materially delay consumma tion of the Transactions ; provided, however, that any events, changes or effects will not be d eemed to constitute a Material Adverse Effect to the extent resulting fro m ( i ) general changes or conditions in general econ omic, political or market conditions or in the industries ( or therapeutic areas ) in which the Product Lines operate, except to the extent that such changes or condition s in the industries ( or therapeutic areas ) in which the Product Lines operate have a disproportionate effect on the Product Lines, taken as a whole compared with othe r companies or businesses operating in such industrie s ( or therapeutic areas ) ; ( ii ) any failure by any S eller Entity or the Product Lines to meet internal projections o r forecasts for any period ( provided that the under lying causes of such failure may be taken into account in determ ining whether there has been a Material Adverse Eff ect ) ; ( iii ) acts of war or terrorism ( or the escalation of the foregoing ) or natural disasters or other force maje ure events ; ( iv ) changes in any Legal Requirements applicable to the Product Lines or applicable accounting regulations or principles or the generally accepted interpretation thereof, except to the extent that such changes in the industries ( or therapeutic areas ) in which the Product Lines o perate have a disproportionate effect on the Produc t Lines compared with other companies or businesses operati ng in such industries ( or therapeutic areas ) ; ( v ) t he acts or omissions of, or circumstances affecting, Purchaser and/or its Affiliates ; ( vi ) compliance by the Sell er Entities or any of their Affiliates with a written request by P urchaser after the date hereof that the Seller Enti ties or any of their Affiliates take an action ( or refrain from ta king an action ) to the extent such action or inacti on is in compliance with such request ; and ( vii ) any action taken by the Seller Entities or any of their Affili ates as required by this Agreement ( other than any action t o comply with Section 6.1 ) or with Purchaser ’s writ ten consent