definiens: means a collaboration involving the discovery and development ofDouble Stranded RNA Products, in which a Party plays an integral role in the experimentation and an important, though not necessarily dominant or co - equal, role in the decision - making, relating to the discovery anddevelopment of Double Stranded RNA Products from the point in time at which the relevant Gene Target hasbeen designated through the initiation of [ * * ] . A Bona Fide Drug Discovery Collaboration may continue beyond theinitiation of such [ * * ] . For Isis Products that are Double Stranded RNA Products, a Bona Fide Drug DiscoveryCollaboration must be an Antisense Drug Discovery Program . For each Party, collaborations that do not includeor involve Patents licensed from the other Party hereunder shall not constitute Bona Fide Drug DiscoveryCollaborations . A Party ’s experimentation relating to the discovery and development of Double Stranded RNAProducts that modulate a relevant Gene Target prior to the commencement of a collaboration shall be deemed tohave been conducted in the course of the collaboration for purposes of determining whether the collaboration is aBona Fide Drug Discovery Collaboration . A series of related collaborations and/or license agreements involvingthe discovery and development of Double Stranded RNA Products with the same sublicensee or relatedsublicensees that includes a Bona Fide Drug Discovery Collaboration agreement will be aggregated to constitutea single Bona Fide Drug Discovery Collaboration