definiens: means, with respect to a particular item and a pa rticular Patent, that, in any of the countries of manufacture, use, and/or sale, ( a ) the composition of such item, of any of its ingredient s or formulations, or of any product containing such ite m or that is made using such item by virtue of such product containing or being made using such item ; ( b ) a met hod of making or using any of the foregoing things referred to in ( a ) ; ( c ) an item used or present in the manufact ure of any of the foregoing things referred to in ( a ) or ( b ) ( for example, with respect to a biologic, any vector, pl asmid or cell line used to manufacture such product or item or any ingredient in either of them ) ; and/or ( d ) any m ethod by which the foregoing things referred to in ( a ), ( b ), or ( c ) was discovered or identified, or another item p resent during or used in such method would, in the absence of a license or assignment, infringe a valid claim of at least one Patent