definiens: means, subject to Sectio n 3.4, ( a ) all Original Targets until the Prelimina ry Target Selection Date, upon which all Original Targ ets ( i ) selected as Preliminary Targets shall conti nue to be Reserved Targets unless and until such Preliminary Targets subsequently become Unreserved Targets and ( ii ) not selected as Preliminary Targets shall become Un reserved Targets ; ( b ) all Preliminary Targets until the Initial Research Target Selection Date, upon which all Prel iminary Targets ( i ) selected as Initial Research Ta rgets shall continue to be Reserved Targets unless and until su ch Initial Research Targets subsequently become Unr eserved Targets and ( ii ) not selected as Initial Research T argets shall become Unreserved Targets ; ( c ) all Ini tial Research Targets until the expiration of the option under Se ction 3.1.1(b ), upon which all Initial Research Tar gets ( i ) selected as Definitive Research Targets or Validate d Targets shall continue to be Reserved Targets unl ess and until such Definitive Research Targets subsequently become Unreserved Targets and ( ii ) not selected as Definitive Research Targets or Validated Targets 16 shall become Unreserved Targets ; ( d ) all Definitive Research Targets until the expiration of the optio n under Section 3.1.2(b ), upon which all Definitive Researc h Targets ( i ) selected as Extended Research Targets or Validated Targets shall continue to be Reserved Tar gets unless and until such Extended Research Target s subsequently become Unreserved Targets and ( ii ) not selected as Extended Research Targets or Validated Targets shall become Unreserved Targets ; ( e ) all Ex tended Research Targets until the expiration of the option under Section 3.1.3(b ), upon which all Extended Res earch Targets ( i ) selected as Validated Targets sha ll continue to be Reserved Targets and ( ii ) not select ed as Validated Targets shall become Unreserved Tar gets ; and ( f ) all Validated Targets