definiens: shall mean when Facility c hanges will be implemented pursuant to the provisio ns of Section 6.03(ii)(B ) and : ( i ) such Facility changes will impact the tota lity of the Total Manufacturing Area and/or the common and technical areas related to manufacturing, the cost of the changes multiplied by a percentag e, where such percentage equals Purification Area PLUS Fermentation Area X Time PLUS Recovery Area X Time Total Manufacturing Area Total Manufacturing Area Total Manufacturing Area ( ii ) when such Facility changes will impact on ly the Fermentation Area, the cost of the changes multiplied by Time ; ( iii ) when such Facility changes will impact o nly the Recovery Area, the cost of the changes multiplied by Time ; 1.38 shall mean that certain Quality Agreement by and between the Parties heret o, dated as of the date hereof and attached to this Agreemen t as Exhibit D