definiens: means, with respect to a Party, the carrying out of obligations or tasks in amanner consistent with the efforts such Party devotes to research, development or marketing of a pharmaceuticalproduct or products of similar market potential, profit potential or strategic value resulting from its own research effortsor for its own benefit, and which efforts shall in any event be no less than those which would be consideredreasonable in the pharmaceutical or biotechnology industries, taking into account technical, regulatory and intellectualproperty factors, target product profiles, product labeling, past performance, costs, economic return, the regulatoryenvironment and competitive market conditions in the therapeutic or market niche, all based on conditions thenprevailing . Commercially Reasonable Efforts shall be determined on a country - by - country basis for a particularLicensed Product and it is anticipated that the level of effort will be different for different markets, and will change overtime, reflecting changes in the status of the Licensed Product, regulatory and competitive environment and marketsinvolved . shall have a corresponding meaning