definiens: means an epitope of a polypeptide arising in a tumor cell, where the epitope comprises a polypeptide thatreflects : ( a ) a non - inherited DNA mutation, ( b ) a tumor specific RNA sequence alteration, or ( c ) an alternative tumor - specific translation startsite in the tumor cell [ * * * ] - 18 -Confidential Execution Copy 1.219 means a methodology of predicting Neoepitopes based on Patient Sequencing, including algorithms, designs, structures, features, functions, processes, and systems, and the underlying software programs ( includinglibraries, databases, scripts, object and source code ) ( ), and any other related Know - How necessary oruseful to use, develop, reproduce, prepare derivative works, distribute, display and perform any of the Neoepitope Prediction Software, andall intellectual property rights other than Patents in any of the foregoing