definiens: means Patent Rights Controlled by Isis or any of its Affiliates on or after the Effective Dateclaiming ( i ) the specific composition of matter of an Isis Development Candidate ; ( ii ) methods of using an Isis DevelopmentCandidate as a prophylactic or therapeutic ; or ( iii ) the specific mechanism of action of an Isis Development Candidate, ineach case to the extent necessary to Develop, Manufacture or Commercialize an Isis Development Candidate ; providedhowever, Patent Rights Controlled by Isis or any of its Affiliates that ( y ) include claims that are directed to subject matterapplicable to ASOs in general, or ( z ) include an ASO, the sequence of which targets both ( a ) the RNA that encodes HTT and(b ) ASOs that do not target the RNA encoding HTT, will not be considered Isis Product - Specific Patents, and in the case of(y ) and ( z ), such Patent Rights will be considered Isis Core Technology Patents . A list of Isis Product - Specific Patents as of theEffective Date is set forth on SCHEDULE 8.2.4(c ) attached hereto