definiens: means, for any period, the aggregate amounts in IUs of ( i ) all Alternative ESAs [ * ] by any Dialysis Center Committed Purchaser for treatment of anemia in patients receiving Dialysis Services at any Dialysis CenterCommitted Purchaser from any source during such period, ( provided, that any Alternative ESA provided to a Dialysis CenterCommitted Purchaser at no or nominal cost from any source shall be considered a purchase ), adjusted to be an equivalent dose ofEPOGEN ( in IUs ) based on the Alternative ESA ’s FDA approved package insert ( if the dose conversion ratio is clearly set forththerein ) or otherwise as reasonably determined pursuant to Section 3.1.5, ( ii ) Aranesp ( in equivalent IUs of EPOGEN using theAranesp - EPOGEN Dose Equivalency Ratio ) purchased by Dialysis Center Committed Purchasers [ * ] net of product returns andadjustments, which aggregate IUs data have been independently confirmed by [COMPANY] through the Relevant Information