definiens: shall mean the identification, op timization and development of molecules which interfere with the normal p rocess of leucocyte adhesion to cellular and extracellular substrates to be used in the treatment of immune and non - immune based inflammatory di seases . Specifically included within the Field are ( a ) Antisense Molecule s which directly inhibit the expression of ICAMs, VCAM-1, PECAM-1, selec tins and(beta)2 integrins, ( b ) compounds which modulate the interactio n of leucocyte integrins, with their respective binding ligands and t he interaction of selectins with their binding structures, ( c ) non - anti sense compounds which modulate the expression of ICAMs, VCAM-1, P ECAM-1, selectins and leucocyte integrins by interfering with in intracellular process, and ( d ) compounds which inhibit the shedding of selectins, ICAMs, VCAM-1, and PECAM-1 from the cell surface