definiens: means an immunoglobulin ( Ig ) molecule, or other composition comprising an amino acid based structure, in eachcase that binds or incorporates one or more moieties capable of binding CD33 or Trem2, including any such composition containing ascaffold based on an Ig molecule or a fragment, alternative form or derivative thereof, or any other amino acid containing structures such asa camelid nanobody, Affibody molecules, Affilins, Affimers, Affitins, Alphabodies, Anticalins, Avimers, DARPins, Fynomers, Kunitz domainpeptides, Monobodies, nanoCLAMPs, Z domain of Protein A, Gamma - B crystallin, Ubiquitin, Cystatin, Sac7d, Triple helix coiled coil, Lipocalins, A domains of membrane receptors, Ankyrin repeat motif, SH3 domain of Fyn, Kunitz domains of protease inhibitors, 10th type IIIdomain of fibronectin, Carbohydrate Binding Module 32 - 2 ), in each case that bind or incorporate one or more moieties capable of bindingCD33 or Trem2 . Notwithstanding the foregoing, Antibodies shall exclude synthetic chemical compositions with a molecular weight of lessthan 500 daltons ( and which are not linked to or otherwise contained within a larger composition of greater than 500 daltons )