definiens: shall mean U.S S N. 08/011,643 filed January 28, 1993, USS.N. 081183,648 filed January 18, 1994, 1994, PCT Application No . PCTfUS94!00740 and other corresponding international applications, and any continuations, continuations - in - part, extensions or reissues thereof 2.6 shall mean U.S S N 08/281,493 fJied July 27, 1994, and other corresponding international applications, and any continuations, continuations - in~ pan, extensions or reissues thereof . Hum~!l . CQ.llagen " shall mean human collagen and modificattons, vanants, denvatives and fragments of human collagen consisting of a sequence of at least@mino aCids ( each such modification, valiant, derivative or fragment haVIng at leas(70Yo homology in amino acid sequence with human collagen or an eqUlva.ient fraction thereot ) produced hy, a.nd in the milk of . tr'ansgemc dairy cattle, provided that the fragment can not be considered to be derIved from another natural protein or peptide or fragment thereof