definiens: means, with respect to particular obligations or tasks, such levelof efforts applied to carry out such obligations or tasks consistent with the efforts used in the biopharmaceutical industry by acompany of comparable size in connection with the development or commercialization of biopharmaceutical products thatare of similar status, to accomplish such obligations or tasks, at the same stage of development or commercialization, asapplicable, for internally developed healthcare products in a similar area with similar market potential, at a similar stage oftheir product life taking into account the existence of third party ( not Licensee 's own ) competitive products in the marketplace or under development, the proprietary position of the product, the regulatory structure involved, the anticipatedprofitability of the product and other commercially - relevant factors . It is understood that such factors may change from timeto time based upon changing scientific, business and marketing and return on investment considerations and that the levelof efforts typically devoted by Licensee may also change, based on such changes and/or changes in development orcommercial stage