definiens: shall mean any product comprised of ( a ) a single - stranded oligonucleotide ( or a single strandedanalog thereof ) that is designed to interfere with or inhibit a particular miRNA, or ( b ) a single - stranded oligonucleotide ( or asingle stranded analog thereof ) that is designed to bind to a miRNA Precursor to prevent the production of one or moremiRNAs . An miRNA Precursor shall mean a transcript that originates from a genomic DNA and that contains, but notnecessarily exclusively, a non - coding, structured RNA comprising one or more mature miRNA sequences, including, withoutlimitation, ( i ) polycistronic transcripts comprising more than one miRNA sequence, ( ii ) miRNA clusters comprising more thanone miRNA sequence, ( iii ) pri - miRNAs, and/or ( iv ) pre - miRNAs . For clarity, miRNA Products do not include(x ) oligonucleotides that function predominantly through the RNAi mechanism of action or the RNase H mechanism ofaction, ( y ) miRNA Mimics or ( z ) miRNA Mimic Precursors