definiens: means ( a ) licenses granted by [COMPANY] before or aft er the Effective Date to any Third Party under the [COMPANY] Core Technology Patents, the [COMPANY] Manufacturing and Analytical Patents, or the [COMPANY] Manufacturing and Analytical Know - How ( but not unde r the [COMPANY] Product - Specific Patents ) to ( i ) use AS Os ( or supply ASOs to end users ) solely to conduct pre - cli nical research, or ( ii ) enable such Third Party to manufacture or formulate ASOs, where ( A ) such Third Party is pr imarily engaged in providing contract manufacturing or services and is not primarily engaged in drug disco very, development or commercialization of therapeut ics ; and ( B ) [COMPANY] does not assist such Third Party to ident ify, discover or make a compound or product ; and ( b ) material transfer agreements with academic collaborators or non - profit institutions solely to conduct non - comme rcial research