definiens: means any preparation for the treatment or prevention of obesity, anorexia or diabetes in humans that : ( d ) incorporates either in its entirety or in shortened form the RIP140 gene or RIP 140 gene product howsoever modified including without limitation nucleotides, oligonucleotides, nucleic acid vectors, peptides, polypeptides, proteins etc . ; or ( e ) is an agent that binds to the RIP 140 gene or an RIP 140 gene product ( excluding the RIP140 protein or any subunit thereof ) with the purpose of enhancing, interfering with, silencing, suppressing or modulating the expression thereof such agents including without limitation complementary sequences, ligands, eDNA, mRNA, tRNA, antibodies, antibody fragments . peptides, fusion proteins, mimetics, aptamers, antisense ( or other nucleic acid based gene or gene product modulators ), ribozymes, molecular imprinted polymers, RNAi, microRN~ dsRNA, siRNA, shRNA, vaccines, immunotberapeutics and gene therapy products ; or ( f ) is an agent ( including without limitation small molecule entities ) that has a mechanism of action through interaction with or binding to the RIP140 protein ( or a subunit thereof ) ; and which have been identified by [COMPANY], a [COMPANY] Affiliate or a [COMPANY] Sublicensee as a direct result of ( i ) the use of the Materials ( or the use of an Improvement to the Materials licensed to [COMPANY] under Clauses 8.1 andlor 8.2 ) or ( ii ) an activity that falls within a Valid Claim