definiens: means the waiver attached to that certain Amendment No . 4 to Collaboration and License Agreement, effe ctive as of April 9, 2019 ), that certain Amendment No . 5 to Collaboration and License Agreement, effective a s of July 15, 2019, that certain Amendment No . 6 to Coll aboration and License Agreement, effective as of September 23, 2019, that certain Amendment No . 7 to Collaboration and License Agreement, effective as of November 7, 2019, that certain Amendment No . 8 to C ollaboration and License Agreement, effective as of December 20, 2019, and that certain Amendment No . 9 to Collaboration and License Agreement, effective as of March 12, 2020 ( such Collaboration and License Agre ement, as so amended, the ) ; and WHEREAS, the Parties now wish to amend and restate the 201 6 Collaboration Agreement so as to incorporate the terms of the foregoing amendments a nd to memorialize certain other clarifications and understandings