definiens: means ( a ) the Target BTK, and ( b ) any Target ( oth er than a Collaboration Target, Substituted Collaboration Target, Replaced Collaboration Target ( solely for the period of time described in Section 2.10.1(b ) ( Target Exclusivity ) ), or Rese rved Target ) that is subject to a bona fide interna l [COMPANY] research program and is not conducted for a Third P arty, where [COMPANY] is conducting active drug discove ry activities ( including activities related to compoun d structure discovery, drug discovery screening, co mpound chemistry, structure - activity relationships and man ufacturing ) with respect to a compound or product t hat is Directed To such Target, provided that [ * ] 1.149 means the [COMPANY] Patents and the [COMPANY] Know - How, b ut excluding any Joint Foreground IP ( including any [ * ] )