definiens: means an analog, hom olog, isomer, isostere or other derivative that [COMPANY] makes from, derives fro m or bases upon any compound within the Early Lead Series by one or more modific ations that results in a compound having a superior profile against an [ ... * * * ... ] target, in one or more respects, as a candidate for further development th an the compound within the Early Lead Series from which it is derived and whic h is identified, by or on behalf of [COMPANY] or any of its Affiliates or sub - lic ensEeS during the Term of the Collaboration or within [ ... * * * ... ] ( [ ... * * * ... ] ) y ears after the Term of the Collaboration ends . The term shall not include any derivatives made by [COMPANY] or any of its Affiliates or sub - licensees without the use of SGX BackgroUnD Technology