definiens: means the gross amounts invoiced by [COMPANY], its Affiliates and their respective sublicensees forsales of Product made to unaffiliated Third Parties, less the following deductions to the extent reasonable and customaryprovided to unaffiliated entities and actually allowed with respect to such sales : ( a ) reasonable cash, trade or quantity discounts, charge - back payments, and rebates actually granted oradministrative fees actually booked to trade customers, patients ( including those in the form of a coupon or voucher),managed health care organizations, pharmaceutical benefit managers, group purchasing organizations and national, state, orlocal governments, and to the agencies, purchasers and reimbursers of managed health organizations, pharmaceutical benefitmanagers, group purchasing organizations, or federal, state or local governments ; provided, however, that in each case suchamounts shall be applied in a normal and customary manner with respect to other similarly situated products of the sellingparty and not applied disproportionately to the Product