definiens: . Commercially Reasonable Efforts means, with respect to the effc'I11s to be expended by a ' Party with respect to a goal, such reasonable, diligent, good faith efforts to accomplis h such goal as a similarly situated ( with respect to size, stage of deve lopm ~ n t, and assets ) biotechnology company would usc to accomplish a similar goal under similar circumstances so as to achieve slich goal in a reasonable period of time ; provided .l_~<lt ., with respect 10 the developmen t, manufacturing or commerciulization of a Collaboration Product, such etlorts shall be subsumtictlly equivalent to those efforts and resources that a similarly situated ( with respect to size, stage of developmen t, and assets ) biotechnology company would typically devote to its own internally discovered products of similar market potential at a similar stage in their development or product life, taking into account issues of safety, efficacy, product prolilc, thc competitiven ess of the marketplace, the proprictary position of the compound or product . the regulatory and reimbursemcnt structure involved, the prolitabili ty of the applicable product, .md other relevant factors . so as to achi ~ ve slich goal in a reasonable period of time ( which . with rl;!spcct to activities for which ThromboGenies is responsible . shall he without regard to ctny amounts paid or payable ( 0 EBI with respect to a Collabonllion Product under this Agreement )