definiens: shall mean ex vivo gene therapy for human disorders limited to adrenoleukodystophy ( ALD)(including but not limited to AMN, CCALD, and all other variants of this disease caused by geneticmutations ), beta hemoglobinopathies ( including but not limited to beta - thalassemia and sickle cell anemia ), [ * * * ] for [ * * * ] the includes in vivo as well as ex vivo gene therapy . [ * * * ] 2.2 . The article 2.1 of the Agreement is modified as follow, as from the effective date of this Amendment n ° 1:“2.1 . Institut Pasteur hereby grants to Licensee, its Affiliates, that Licensee, its Affiliates accept at their own risk, a licenseunder the Patents in the Field and in the Territory for research and development, and to manufacture, have manufactured, make, have made, use, have used, sell, have sold, offer for sale, have offered for sale, import or have imported the Products, tothe exclusion of any other rights, the said license being : • exclusive for Products containing human ( HIV-1 and HIV-2 ) lentivirus vector ; • nonexclusive for Products containing non - human lentivirus vector