definiens: means all fees and other payments received by Reg ulus from a Collaborator in connection with a Sublicense Income Agreement, but excluding ( i ) debt, credit or lease financing ( provided, however, that ( x ) any discount to market will not be excluded from the definition of Sublic ense Income and ( y ) in the event that any portion of suc h debt, credit or lease is forgiven, such debt, cre dit, or lease will be deemed Sublicense Income in the amount of s uch forgiveness ), ( ii ) the fair market value of any equity investments in Regulus, ( iii ) the bona fide reimbur sement of future research and development funding b y a third party ( as specified in the Sublicense Income Agreem ent ) at direct cost, ( iv ) the bona fide reimburseme nt of future out - of - pocket costs of patent filing, prosec ution and maintenance, and patent defense, and ( v ) royalties for which compensation is paid to Alnylam and Isis purs uant to Section 5.2(d )