definiens: means, on an R&D Program - by - R&D Program basis, the period of time commencing on theEffective Date and covering the period of time in which the Parties are conducting Stage 1 and Stage 2 activitiesunder the applicable Research Plan for such R&D Program . The Research Term shall expire, on an R&D Program - by - R&D Program basis, upon the earlier of : ( i ) completion of all Stage 1 activities and Stage 2 activities for such R&DProgram ; or ( ii ) * * * ( * * * ) years after the Effective Date, provided that if the Parties have initiated a clinical trial underthe Stage 2 activities for such R&D Program prior to the expiration of such * * * ( * * * ) year period, then the ResearchTerm shall be automatically extended until the completion of such clinical trial under the Stage 2 activities for suchR&D Program . The Research Term for an R&D Program also may be extended by mutual written agreement of theParties