definiens: means ( a ) oligonucleotides that bind to a Feasibility Study Target by means other thanWatson - Crick base - pairing that consist of or incorporate structural elements that are generally applicable to sucholigonucleotides independent of Feasibility Study Targets ( e.g., a novel nucleoside, bond or linkage or combination(s)thereof, for example, deoxypurine and 2’O - methyl substituted prymidine compositions ) as used in such oligonucleotides, and(b ) any process for modifying, optimizing and/or stabilizing oligonucleotides that bind to a Feasibility Study Target by meansother than Watson - Crick base - pairing that is generally applicable to such oligonucleotides independent of Feasibility StudyTargets wherein such modification, optimization or stabilization includes, without limitation, minimization, truncation, conjugation, pegylation, complexation, substitution, deletion and/or incorporation of modified nucleotides ; provided, however, that SELEX Technology does not include Active Aptamers and that the SELEX Technology is covered by theclaims in ( a ) the SELEX Portfolio, ( b ) the [COMPANY] Portfolio, or both or ( c ) any continuation, divisional, continuation - in - part, substitution, renewal, reissue, re - examination or extension, or any foreign equivalent, of any such claims