definiens: means ( a ) ( 1 ) Guilford 's research for the evaluation of NAALADase inhibitor conjugated to chemotherapy and radiotherapy for the treatment of prostate cancer ; ( 2 ) Guilford 's research for the formulation and evaluation of I.V. NAALADase inhibitors in acute conditions of glutamate toxicity, such as traumatic brain insult, spinal cord injury, cardiac arrest and/or global ischemia ; and ( 3 ) Guilford 's proposed clinical trial and research withkhe NIDAtfor the evaluation of NAALADase inhibitors for the treatment of drug addiction ; and any agreements covering or arising out of any of the above - described trials or research ; and ( b ) such other collaborations as Guilford may enter into following notice to and approval by [COMPANY] of such collaborat ions . Unless_o rwise agreed to by [COMPANY], Guilford shall not use, PI 15890 or GPI 16072 or any other Guilford compounds as to which [COMPANY] has previously notified Guilford that it intends to pursue in development ) in connection with the Guilford Collaborations