definiens: shall mean, for the applicable period, the gross amount invoiced by SAVARA and its Affiliates on account of sales of the Product to th ird parties as a human therapeutic for MRSA in cyst ic fibrosis, less the total of deductions not otherwis e reimbursed by the customer for : ( a ) normal and customary trade, quantity and cash discounts and sa les returns and allowances, including ( i ) those granted on account of price adjustments, billing er rors, rejected goods, damaged goods, returns, rebat es, and refunds, ( ii ) administrative, management, and o ther fees and reimbursements and similar payments to wholesalers and other distributors, buying group s, pharmacy benefit management organizations, health care insurance carriers and other institutio ns, ( iii ) allowances, rebates, and fees paid to distributors, ( iv ) chargebacks, and ( v ) any other a llowances that effectively reduce the net selling p rice ; ( b ) customs and excise duties and other duties rela ted to the sales to the extent that such items are included in the gross amount invoiced ; ( c ) rebates and similar payments made with respect to s ales paid for by any governmental or regulatory authority ; ( d ) sales, 12 use, excise, or value - added taxes and other taxes a nd duties directly related to the production, sale, delivery, or use of the Product ( but not including taxes assessed against the income derived from such sale ) ; and ( e ) the cost of freight, postage, shipping, insurance, and special packaging