definiens: means all Patents ( including all claims and the entire scope of claims therein ) Controlledby Isis or its Affiliates on the Effective Date and/or at any time thereafter, including those patents assigned to OMIpursuant to Article 9 in each case claiming ( a ) the sequence or a portion thereof corresponding to the GCCR, GCGRor Selected Gene Target gene sequence or a portion thereof, ( b ) the specific composition of matter of a Product, ( c)methods of using a Compound or Product as a therapeutic or ( d ) methods of using a Compound as a therapeutic);provided however, that ( x ) for any such Patents that include Pass Through Obligations, the provisions of Section 6.5will govern whether such Patent will be included as an Product Specific Patent and ( y ) unless the Parties otherwiseagree in writing, Patents that include claims that are directed to subject matter and have a scope that is applicable toASOs in general, and not specifically directed to a Compound or Product, will be considered to be Isis CoreTechnology Patents ( or Isis Manufacturing and Analytical Patents, as applicable ) . For clarification, any Isis ProgramPatent or any Joint Patent satisfying the definition above, will be considered a Product Specific Patent . The ProductSpecific Patents as of the Effective Date are listed in Appendix 2 attached hereto