definiens: shall mean, collectively, the act ivities pertaining to the development of a syntheti c chemical process and/or finished dosage development studies and formulation for a SELECTED COMPOUND to enable PRODUCTION of a PRODUCT ( which may includ e, without limitation, research studies, process optimization, the scale - up of an existing process a nd delivery of samples of SELECTED COMPOUND ) that a re described as Phase I – Laboratory under Scope of Wo rk in the mutually agreed upon sub - appendix to Appe ndix B applicable to that PRODUCT . A separate sequential ly numbered sub - appendix ( B-1, B-2 and so on ) shall be prepared for each SELECTED COMPOUND for which SIEGF RIED undertakes DEVELOPMENT at TARGACEPT ’s request hereunder, which sub - appendix s hall include the costs chargeable to TARGACEPT for such services ( based on the rates specified herein ), be dated and signed by an authorized employee of each party, attached hereto and thereupon become a part hereof