definiens: . Hedgehog Pathway shall mean all of the following members of the Hedgehog cell - signaling pathway : ( i ) all hedgehog ligands ( Sonic, Indian, Desert ) and transmembrane transport - like proteins, like Disp1 orDisp2, involved in the secretion of the HH ligand, ( ii ) Smoothened ( Smo ), including alternatively spliced forms and Smo withactivating mutations, ( iii ) all Gli transcription factors ( Gli 1, 2, 3 ), ( iv ) mutated or unmutated 5Patched ( Ptch ) receptor 1 and 2, ( v ) Cdo, Cdon and Boc ( brother of Cdo ), ( vi ) Suppressor of Fused ( SuFu ), ( vii ) Cdc2l1 kinase,(viii ) Hedgehog interacting protein ( HHIP ), and ( ix ) ARL13B