definiens: means a polypeptide that Targets an antigen, whic h polypeptide comprises : ( a ) one or more immunoglobulin variable domains ; ( b ) one or more fragments, variants, modifications or derivat ives of such immunoglobulin variable domains irrespective o f origin or source, including antigen binding porti ons, fragments ( including Fab, Fab ’, F(ab’)2, Fv, dAb an d CDR fragments ), single chain antibodies ( scFv ), c himeric antibodies, monospecific antibodies, bispecific ant ibodies, multi - specific antibodies, diabodies and o ther polypeptides, any of which contain at least a porti on of an immunoglobulin variable domain that is suf ficient to confer specific -2- Portions of this Exhibit, indicated by the mark were omitted and have been filed separately w ith the Securities and Exchange Commission pursuant to the Registrant ’s application requesting confidential tr eatment pursuant to Rule 24b-2 of the Securities Exchange A ct of 1934, as amended