definiens: means the total gross invoice price received from the sale of all Synvisc Products by Genzyme, its Affiliates and licensees in the Territory during the Term to non - Affiliated distributors, wholesalers, hospitals, retail pharmacies, patients, physicians, clinics and other Third Party purchasers, less, provided that such items do not exceed reasonable and customary amounts in the Territory, ( i ) trade, cash and quantity discounts actually allowed and taken with respect to such sales or because of rebates or retroactive price reductions and billing corrections with respect to sales ; ( ii ) tariffs, duties, excises, sales taxes, value added or other taxes imposed upon and paid with respect to such sales ( excluding national, state or local taxes based on income ) ; ( iii ) amounts repaid or credited to third party purchasers by reason of rejections, defects, recalls or return ; and ( iv ) reasonable freight, transportation and insurance expenses actually paid . Such amounts shall be determined from the books and records of Genzyme, its Affiliates and licensees maintained in accordance with generally accepted accounting principles, consistently applied