definiens: means ( a ) oligonucleotides that bind to a Target by means other than Watson - Crick base - pairing that consist of or incorporate structural elements that are generally applicable to such oligonucleotides independent ofTargets ( e.g., a novel nucleoside, bond or linkage or combination(s ) thereof, for example, deoxypurine and 2’O - methylsubstituted prymidine compositions ) as used in such oligonucleotides, and ( b ) any process for modifying, optimizing and / orstabilizing oligonucleotides that bind to a Target by means other than Watson - Crick base - pairing that is generally applicableto such oligonucleotides independent of Targets wherein such modification, optimization or stabilization includes, withoutlimitation, minimization, truncation, conjugation, pegylation, complexation, substitution, deletion and/or incorporation ofmodified nucleotides ; provided, however, that SELEX Technology does not include Program Aptamers