definiens: means the gross amount invoiced on sales of Licensed Product in the Territory by Trev i, its Affiliates and Sublicensees to any Third Party, less the following deductions with respect to the sale of such Licensed Product, in each case, calculated in accor dance with GAAP, consistently applied : ( i ) normal trade, cash and quantity discounts and o ther customary discounts actually given to customers in the ordinary course of business ; ( ii ) rebates, credits and allowances given by reaso n of rejections, returns, damaged or defective product or recalls ; 3 ( iii ) government - mandated rebates and any other com pulsory payments, credits, adjustments and rebates actually paid or deducted ; ( iv ) price adjustments, allowances, credits, charge back payments, discounts, rebates, fees, reimbursements or similar payments granted to manag ed care organizations, group purchasing organizations or other buying groups, pharmacy bene fit management companies, health maintenance organizations and any other providers of health ins urance coverage, health care organizations or other health care institutions ( including hospitals ), hea lth care administrators or patient assistance or ot her similar programs, or to federal, state / provincial, local and other governments, including their agenci es, or to wholesalers, distributors or other trade custome rs ; ( v ) reasonable and customary freight, shipping, ins urance and other transportation expenses, if actually borne by such Trevi or its Affiliates or S ublicensees without reimbursement from any Third Pa rty ; ( vi ) sales, value - added, excise taxes, tariffs and duties, and other taxes and government charges directly related to the sale, delivery or u se of Licensed Product ( but not including taxes ass essed directly against the income derived from such sale ) net of any credits or allowances received by Trevi or its Affiliates or Sublicensees with respect to such taxes or charges ; ( vii ) amounts previously included in Net Sales of L icensed Product that are written off as uncollectible after reasonable collection efforts, in accordance with standard practices of the applic able party ; and ( viii ) any item, substantially similar in character or substance to any of the foregoing, calculated in accordance with GAAP consistently app lied and customary in the pharmaceutical industry t o be deducted in the definition of net sales in a lic ense agreement of this type