definiens: means, with respect to a party, such efforts that areconsistent with the efforts and resources normallyused by such party in good faith in the exercise ofits reasonable business discretion relating to theresearch and development of a potentialpharmaceutical product owned by it or to which ithas exclusive rights, with similar productcharacteristics, which is of a similar market potentialat a similar stage in its development or product life, taking into account issues of patent coverage, safety and efficacy, product profile, thecompetitiveness of the marketplace, the proprietaryposition of the compound or product, the regulatorystructure involved, the profitability of the applicableproducts ( including pricing and reimbursement statusachieved ), and other relevant factors, includingtechnical, legal, scientific and/or medical factors . Forthe purpose of clarity, Commercially ReasonableEfforts would be determined on a marketby - marketand indication - byindication basis for a particularproduct and it is anticipated that the level of effortmay be different for different markets and maychange over time, reflecting changes in the status ofthe product and the market involved ; 1.1.3