definiens: . sha ll mean [COMPANY] ’s costs of manufacturing the Product, including Amphotericin B and all other direct mater ials, labor, quality control and freight costs as w ell as manufacturing overhead and other general and admini strative costs directly associated with the manufac turing of the Product, allocated according to generally accep ted accounting principles ( ) ; provided, howev er, that general and administrative expenses will not includ e any expenses not directly related to the day - to - d ay management of [COMPANY] ’s business . During 1991, Gilea d ’s cost / unit is projected to be [ * ] per vial . The parties agree that this figure will be used in lieu of the Standard Cost / Unit for 1991 and that the Standard C ost / Unit will not be greater than [ * ] per vial in 1992 . For each subsequent calendar yea r, the Standard Cost / Unit will be the actual cost / unit experienced by [COMPANY] in the twelv e ( 12 ) months ended December 31 of the immediately preceding year ; provided, however, that in the even t a mid - year pricing review is requested pursuant t o Paragraph 4.6, then for the second half of the then current calendar year the Standard Cost / Unit will be the actual cost / unit experienced by [COMPANY] in the six ( 6 ) mont hs ended June 30 of the then current year