definiens: shall mean the ongoing expenditure of reasonable resources ( including under the Sponsored Research Agreement ) toward the commercialization of a Licensed Product in one or more of the following activities : marker validation, assay development, preparation or performance of clinical studies, data analysis, test manufacturing, preparation for or pursuit of regulatory approvals or payor coverage, preparing or offering to sell . For purposes of clarification, any of th e foregoing activities for a Licensed Product constitutes Active Development of all markers remaining under Active Development for all Licensed Product for the same cancer, precancer, disease or condition . The Parties acknowledge that ( i ) a marker may be u nder Active Development for multiple Licensed Products ( including Licensed Products for the same cancer, precancer, disease or condition ), ( ii ) a marker would be considered to remain under Active Development during reasonable pauses between development act ivities, provided that such pause lasts no longer than six months and ESDC maintains the good faith intention to continue development of such marker for a Licensed Product, ( iii ) discontinuation of Active Development with respect to a marker for one Licens ed Product does not constitute discontinuation of Active Development with respect to a marker for any other Licensed Product, and ( iv ) activities performed by a diagnostic reference laboratory that is not an Affiliate of ESDC under a sublicense do not cons titute Active Development