definiens: means, ( a ) with regard to a Sequence, that such S equence binds directly to a Target ; and ( b ) with regard to an Antibody, Researc h Product, Back - up Product or Licensed Product, tha t such Antibody, Research Product, Back - up Product, or Lic ensed Product binds directly to a Target and exerts diagnostic, prophylactic or therapeutic activity as a result of such binding or modifies the profile ( e.g., pharmacokinetics, tissue penetration and distributi on ) of the Antibody, Research Product, Back - up Prod uct or Licensed Product as a result of such binding, [ … * * * … ] 13, in either case available to ICONIC at the time of its submission of the Designation Notice for the applic able Sequence . When required grammatically, the def ined term may be separated and shall have the s ame meaning set forth above ; e.g., when discussing Targets To which an Antibody is Directed