definiens: means [ any molecule that ( a ) has a molecular weight less than or equal to one thousand ( 1,000 ) daltons, ( b ) is known, prior to the initiation of the first clinical trial for a Product contammg such molecule, to have the ability to ( i ) directly inhibit, activate or otherwise modulate the activity of a Selected Target, or ( ii ) inhibit, activate or otherwise modulate the activity of a Selected Target or its encoded protein in an assay measuring the activity of such Selected Target, and ( c ) such ability is identified by or on behalf of a Party or its Affiliate or sublicensee, after the selection of a Selected Target by such Party, through the use to any material extent of such Selected Target or any Infonnation relating to such Selected Target, wherein such Infonnation is developed by or on behalf of a Party or its Affiliate or sublicensee through material use of such Selected Target, the DNA sequence relating thereto, or any other data disclosed hereunder to such Party by the other Party that directly relates to such Selected Target or to the Model System Target to which such Selected Target is a human orthologue