definiens: shall mean such level of effortsrequired to carry out such obligation in a manner consistent with the efforts that a pharmaceutical companycomparable with Pieris would devote at the same stage of development or commercialization, as applicable, forits own internally developed therapeutic products in a similar area with similar market potential, at a similar stageof its product life, taking into account the existence of other competitive products in the market place or underdevelopment, the proprietary position of the product, the regulatory structure involved, intellectual propertyconsiderations, the anticipated profitability of the product and other relevant factors . It is understood that suchproduct potential may change from time to time based upon changing scientific, business and marketing andreturn on investment considerations . For avoidance of any doubt, the fact that there may be competing productdevelopments within Pieris shall not constitute a factor to be taken into account in the determination ofCommercially Reasonable Efforts . Further, for the avoidance of doubt, Commercially Reasonably Efforts do notrequire Pieris to seek to market any therapeutic product in every country or seek to obtain regulatory approval inevery country or for every potential Indication