definiens: means ( a ) with respect to activities of ARQULE in the ResearchProgram and/or in the Commercialization of any Co - Commercialized Licensed Products, the efforts and resources comparableto those undertaken by ARQULE in pursuing the research, discovery or commercialization of proprietary materials and thedevelopment of product candidates, as applicable, that are not subject to the Collaboration and that are at an equivalent stageof development or commercialization and have similar market 6 potential and are at a similar stage in their lifecycle ; and ( b ) with respect to activities of DS in the Research Program, theDevelopment of a particular Licensed Product or the Commercialization of a particular Licensed Product ( including any Co - Commercialized Licensed Products ), the efforts and resources comparable to those undertaken by DS in pursuing intellectualproperty protection and development of product candidates and commercialization of products, as applicable, that are notsubject to the Collaboration and that are at an equivalent stage of development or commercialization and have similar marketpotential and are at a similar stage in their lifecycle