definiens: means, with respect to the [COMPANY], that level of efforts and resources required to carry out a particular task or obligation in an active and sustained manner consistent with the general practices followed by [COMPANY] in the exercise of its reasonable business discretion relating to other pharmaceutical products owned by it, or to which it has exclusive rights, which are of similar market potential at a similar stage in their development or product life, taking into account issues of patent coverage, sa fety and efficacy, product profile, the competitiveness of products in development and in the marketplace, supply chain management considerations, the proprietary position of the compound or product, the regulatory structure involved, the profitability of the application products ( including pricing and reimbursement status achieved ), and other relevant factors, including technical, legal, scientific and/or medical factors . For purposes of clarity, Commercially Reasonable Efforts will be determined on a coun try - by - country basis within the Territory, and it is anticipated that the level of effort may be different for different countries and may change over time, reflecting changes in the status of the Product and the country(ies ) involved