definiens: means:(a ) with respect to EPIZYME, such efforts that are consistent with the efforts and resources normally used byEPIZYME in the exercise of its reasonable business discretion relating to the Development and commercial progression of apotential pharmaceutical product:(i ) that is at a similar stage in its Development or product life as the relevant Compound, LicensedCompound or Licensed Product ; and(ii ) that has commercial and market potential similar to the relevant Compound, Licensed Compound orLicensed Product, taking into account issues of intellectual property scope, subject matter and coverage, safety and efficacy, product profile, competitiveness of the marketplace, proprietary position and profitability ( including pricing andreimbursement status achieved or likely to be achieved ) ; and(b ) with respect to EISAI, such efforts that are consistent with the efforts and resources normally used by EISAIin the exercise of its reasonable business discretion relating to the Development and Commercialization of a potentialpharmaceutical product:(i ) that is at a similar stage in its Development or product life as the relevant Compound, LicensedCompound or Licensed Product ; and(ii ) that has commercial and market potential similar to the relevant Compound, Licensed Compound orLicensed Product, taking into account issues of intellectual property scope, subject matter and coverage, safety and efficacy, product profile, competitiveness of the marketplace, proprietary position and profitability ( including pricing andreimbursement status achieved or likely to be achieved, and royalties and other payments required under this Agreement )