definiens: means, with respect to a Penn Licensed Product : ( a ) the specific indication(s ) designaiedirt an IND ( or its equivalent ) filed on such Penn Licensed Product in any Major Nation ; and ( b ) up to three additional disease indications each of which is specific enough that it could apPropriately be the subject of an IND or equivalent, and for which an 1ND or equivalent is expected to be filed within the next five years for a Penn Licensed Product incorporating the same Gene as such Penn Licensed Product and/or one or more of up to four additional Genes that are believed to act in the same mechanistic pathway as the Gene(s ) incorporated in such Penn Licensed Product . Targeted shall designate the additional disease indications and additional Genes referred to in clause ( b ) within six ( 6 ) months following the first filing of an INn or equivalent on such Penn Licensed Product in any Major Nation ; provided, however, that as to Penn Licensed Products covered by Group 2 Patents, Targeted may designate such additional disease indications and additional Genes at an earlier time as described in Section 4.2.3 . If, within such five years following the filing of the IND or equivalent referred to in clause ( a ), none of Targeted or its Affiliates or licensees has actually filed an IND or equivalent in at least one Major Nation for a Penn Licensed Product directed to a particular disease that was so designated, then that designated disease shall from that time forward no longer be among the Exclusive fudications with respect to the Penn Licensed Product that was the subject of the IND or equivalent referred to in clause ( a )