definiens: means : ( a ) either of the lead molecules of Arena known as AR244061 and AR24688I. as more panicularl y described in Exhibit A of this Agreement ; or ( b ) any molecule deemed to be an Active Compound by unanimolls written consent of all members of the JSC ; or ( c ) any other composition of matter, including a small molecule, protein, antibody, or other compound : * CONFIDENTIAL TREATMENT REQUESTED l. ( i ) that is Controlled by Arena or any of its Affiliates, or is owned or licensed by J&J or any of their respective Affiliates, as of the Effective Date or at any time prior to the fITst anniversary of the end of the Research Term ; and ( ii ) that ( I ) modulates ( including antagonism, inverse ngonism, agonism and any variations thereof ), or, in the case of a prod rug, that on administration to a mammal, generates a species that modulates, 19AJ with an SCSO or leso equal to or less than 50 ~ nM in 293 cells ( assay protocol attached in Exhibit B ) ; and ( 2 ) affects or blocks 19AJ agonist-~ induced insulin secretion with an EC50 equal to or less than 1 ~IM in HIT cells ( assay protocol .:t - attached in Exhibit B ) ; and ( iii ) for which the activity criteria in subsection ( c)(ii ) above either : ( 1 ) is known to Arena and/or J&J ( or an Affiliate of either of them ) as of the Effective Date ; or ( 2 ) is discovered or identified by or on behalf of, or otherwise becomes known to, Arena andlor J&J ( or an Affiliate of either of them ) during the Research Term or the one year period after the end of the Research Ternl, which shall include any compound : ( A ) that is generically or specifically described within a claim, describing a genus or species of compounds the utility of which is given ( in the applicable patent or patent application ) as modulation of 19AJ, in any pending or issued Arena Patent, J&J Patent or Joint Patent filed in the United States or Japan or as a European Patent Application, or as a Patent Cooperation Treaty ( " PCT ' ) application designating the United States and the contracting states of the European Patent Convention, and as to which at least one member of such genus or species is one of the compounds in subsection 1.2(a ), or meets the requirements of subsections 1.2(c)(i ) and 1.2(c)(ii ), and ( B ) provided Ihal such compound is synthesized and assayed and determined to meet the requirements of subsection 1.2(c)(ii ) by or on behalf of Arena andlor J&J ( or an Affiliate of either of them ) prior to the first anniversary of the end of the Research Term