definiens: ) ; and WHEREASThe Research Period defined under the R&L Agreement commenced on 2 June 2005 and ended on 1 June 2008(the ) ; and WHEREASan Additional Research was performed in parallel with the Original Research, between 1 June 2007 and until 31May 2008, pursuant to the First Addendum Agreement, dated : 19.08.07 ( the and the, respectively ) ; and WHEREASthe Parallel Research was extended by the First Extension Period, which commenced on 12 December, 2008 andended on 20 April, 2009, under the Second Addendum Agreement, dated : 5 March, 2009 ( the and the, respectively ) ; and WHEREASconcurrently with this Fourth Addendum Agreement ( ), the parties intend to enter into a ThirdAddendum Agreement which sets forth several understandings in regard to ( inter alia ) the, the and the ( all as defined and more fully specified therein ) ( the ) ; and Ref . : 09 - 2595 - 09 - 37No . : 114395_003 1 WHEREASthe parties wish to further extend the Parallel Research ( which extended the Research that was defined under theR&L Agreement and forms a part thereof ), by an additional research period of one year, under the research planand budget specified herein, and under all terms and conditions set out herein below