definiens: means all inventions, know - how, trade secrets, and other proprietary information ( whether patented or not ), that relate to AMPAkines and which are owned by or licensed to Cortex as of the Effective Date or during the term of this Agreement, as to which Cortex has the right to grant to [COMPANY] an exclusive license hereunder . 1A6 ~I 1.5 1.6 1.7 1.8 1.9 1.10 loll 1.12 means the cost invoiced by the manufacturer of the Products for the Products as well as any pharmaceutical formulation, packaging and/or package insert costs incurred by [COMPANY] . 2 means the treatment of depression and depression related disorders and symptoms as listed under the caption of the most recent DSM at the date of first sale of Products or captions applicable to depression and depression related disorders and symptoms at that time and thereafter during commercialization