definiens: shall mean ex vivo Gene therapy for human disorders limited to adrenoleukodystophy ( ALD ) ( including but not limited to AMN, CCALD, and all other variants of this disease caused by genetic mutations ), beta hemoglobinopathies ( including but not limited to beta - thalassemia and sickle cell anemia ), [ hemophilia, lysosomal storage disorders ( LSDs, including Gaucher disease, Fabry disease, Pompe disease or GAA deficiency, and mucopolysaccharidosis I, II and VI ), " IV / AIDS, ) leukemias, lymphomas, 8 - cell malignancies and solid tumors by producing chimeric antigen receptor T - cells [ that target specific tumor antigens ( TSA ), including those TSA that are specific to B cell malignancies and solid tumors and are present only on tumor cells and not on any other cell, and/or tumor - associated antigens which are present on some tumor cells and also some normal cells, eye diseases ( including but not limited to AMD and Stargardt disease ), and Parkinson 's Disease ; ] for [ Parkinson 's Disease ) and [ eye diseases ( including but not limited to AMD and Stargardt disease ) ) the includes in vivo as well as ex vivo Gene therapy . [ Licensee and/or Affiliates shall have the right to request Institut Pasteur to expand the definition of the to include additional clinical areas . To expand the Field, Licensee and/or Affiliates shall provide written notification to Institut Pasteur that it or its Affiliates has initiated a program in such area(s ) . If Institut Pasteur does not object, the Parties shall execute a formal amendment to the Agreement within sixty ( 60 ) days thereafter