definiens: means, as of the Effective Date, the Santaris Agr eement, UNC Agreement, and UT Southwestern Agreements . Upon the selection of the Third Target, the Parties shall a mend this definition as necessary to add all additional license agreements between Miragen and a Third Part y entered into before the Effective Date pursuant to which Mi ragen has a sublicensable license to Miragen Therap eutic IP that covers such Third Target or Licensed Oligos th at directly and selectively modulate such Third Tar get . Upon the selection of a Replacement Target, the Parties shall amend this definition as necessary to add all additional license agreements between Miragen and a Third Part y entered into before the Effective Date pursuant t o which Miragen has a sublicensable license to Miragen Ther apeutic IP that covers such Replacement Target or L icensed Oligos that directly and selectively modulate such Third Target . Upon the selection of a Replacement T arget, the Parties shall amend this definition to remove all l icense agreements between Miragen and a Third Party pursuant to which Miragen has a sublicensable license to int ellectual property that is no longer Miragen Therap eutic IP because it covers a member of the microRNA target f amily that was replaced by such Replacement Target or Licensed Oligos that directly and selectively modul ate such member