definiens: shall mean all trade secrets, know - how, and other conﬁdential and proprietaryinformation owned by BRNI or licensed to NRV II by BRNI on or subsequent to the Effective Date, to the extent covering any of the following : ( i)an in vitro therapeutic test system that uses cultured human ﬁbroblasts or any other method to detect and measure PKC and/or otherassays with peripheral cells to predict the presence of Alzheimer ’s Disease in humans, and all succeeding test formats ( including testkits ) ; ( ii)the PKC activators ( including bryostatin, analogs, PUFAs, and other PKC activators ) and their therapeutic applications in humans oranimals ; ( iii)the LDL or ApoE - based drug delivery system that is targeted to enhance access of all manner of drugs and therapeutics to the brain byfacilitation of transport of such drugs across the Blood - Brain - Barrier in humans or animals ; and ( iv)the carbonic anhydrase activators and their therapeutic applications in humans or animals