definiens: . Surrogate Marker means any biomolecule ( including but not limited to Polymorphisms ; proteins, sugars and lipids ) or chemical compound ( including but not limited to drugs and metabolites thereof ), where the absence, presence or quantity of such biomolecule or chemical compound in an individual is measurable or correlated to a statistically robust degree with one or more HAPTM Markers, Collaboration RESPECT Haplotypes or [COMPANY] Polymorphisms referenced in a GNSC SADR HAPTM Marker Association, Collaboration SADR Haplotype Association, GNSC SER HAPTM Marker Association, Collaboration SER HApTM Marker Association, [COMPANY] SER Polymorphism Association or [COMPANY] SADR Polymorphism Association, unless such biomolecule was independently identified as being correlated with the -12 - CONFIDENTIAL underlying Clinical Phenotype without use of information relating to such HAPTM Markers or Collaboration Respect Haplotypes or the related Marker Associations