definiens: means the Programs with respect to the following Program Targets : [ * * * ] ; provided, however, that within [ * * * ] following the Effective Date, Licensee may, at its option, withou t any additional payment, and upon notice to [COMPANY], rep lace [ * * * ] with a Program Target from the Ongoing Programs ; provided further that [COMPANY] shall have no obligation to begin activities under a Program P lan for [ * * * ] unless and until Licensee notifies [COMPANY] th at Licensee plans to proceed with [ * * * ] as an Initi al Program or the expiration of such [ * * * ] period without Lice nsee replacing [ * * * ] as an Initial Program . In the event that Licensee nominates another Target other than [ * * * ], [ * * * ] shall continue to constitute a Target as par t of the Ongoing Program and shall not be considered a Decli ned Program ( and, for avoidance of doubt, if Licens ee then determines to include [ * * * ] as a New Program, Licen see shall be obligated to pay the Upfront Option Fe e )