definiens: means ( a ) wit h respect to the efforts to be expended by a Party to accomplish a particular objective, the good fait h and diligent efforts that such Party and its Affi liates would normally use to accomplish a similar objective unde r similar circumstances, and ( b ) with respect to th e [ * ], such efforts as are [ * ] for a comparable product, taking into account comm ercially relevant factors such as ( as applicable ) stage of development, product life, mar ket potential and regulatory issues . Commercially R easonable Efforts shall be determined on a market - by - market a nd indication - by - indication basis for the Product a nd it is anticipated that the level of effort may be differe nt for different markets, and may change over time, reflecting changes in the status of the Product and the market ( s ) involved . Without limiting the forgoing, Commer cially Reasonable Efforts with respect to the Product requ ires that the relevant Party and its Affiliates : ( i ) set and consistently seek to achieve specific objectives fo r carrying out its obligations, and ( ii ) consistent ly make and implement decisions and allocate resources for the purpose of advancing progress with respect to such objectives