definiens: means any Know - How, invention or discovery ( and all Intellectual Property claiming orcovering such invention or discovery ) ( a ) conceived, discovered, or made in the course of the Research Program ( as definedin the Existing License ) or otherwise in connection with this Agreement by either Party ( or any Aﬃliate thereof ), solely orjointly with the other Party ( or any Aﬃliate thereof ) or ( b ) conceived, discovered, or made by or on behalf of Naia ( or anyAﬃliate thereof ) or any Sublicensee in the development or commercialization of the Licensed Product or any BackupMolecule, in each of cases ( a ) and ( b ), whether patentable or not, to the extent such Know - How, invention or discovery is ( i ) related solely to Amunix Background Technology concerningXTEN Sequences or ( ii ) ( 1 ) directly related to XTEN Sequences, but excluding modiﬁcations to Naia BackgroundTechnology or Naia Improvements for use with XTEN Sequences, and ( 2 ) severable from Naia Background Technology . Forpurposes of clarity, ( x ) Amunix Improvements includes ( I ) any and all derivative, modiﬁed, or truncated amino acid sequencecompositions of XTEN Sequences conceived, discovered, or made in connection with this Agreement by either Party(or anyAﬃliate thereof ), solely or jointly with the other Party ( or any Aﬃliate thereof ), or any Sublicensee, ( II ) any XTENModiﬁcations conceived or discovered by either Party ( or any Aﬃliate thereof ), solely or jointly with the other Party ( or anyAﬃliate thereof ), or any Sublicensee as a result of Naia ’s, its Aﬃliate ’s, or Sublicensee ’s exercise of any rights granted byAmunix under this Agreement or knowledge of Amunix ’s Conﬁdential Information, or ( III ) methods of making such aminoacid sequence compositions conceived, discovered, or made in the course of the Research Program or otherwise inconnection with this Agreement by either Party ( and in each case of clauses ( I ) – ( III ) all Intellectual Property claiming orcovering such invention or discovery ) and, notwithstanding anything to the contrary, ( y ) Amunix Improvements do notinclude, to the extent conceived, generated, or invented by or on behalf of Naia, any Aﬃliate thereof, or any Sublicensee, solely or jointly with Amunix, any Aﬃliate thereof, or any Third Party, any methods or uses for the treatment of indications ortreatment regimens for Licensed Products or XTEN Sequences