definiens: is taken to mean a LabChip device having a system capable of accessing fluid solutions from conventional fluid vessels having 9 mm spaced wells, such as a 96 - well plate . ] [ HT -Format Mobility Shift Assays : The first example could be a kinase assay in which the modification of a fluorescent peptide by the kinase will be detected as its mobility changes in an electric field . ] [ HT -Format Soluble Receptor Binding Assays : Such an assay could involve targets such as nuclear receptors or other binding proteins and might be accomplished by fluorescence polarization or by mobility shift . ] [ HT -Format Cell - based Assays based on Calcium Flux ] [ Fixed dilution capability for a first class of assay : The ability to access nanoliters of compound directly from DMSO stock and dilute in assay buffer to a fixed DMSO concentration will be provided for at least one of the types of assays described above . ] [ I = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH TIlE SECURITIES AND -EXCHANGE COMMISSION PURSUANT TO RULE 406 OF TIlE SECURITIES ACT OF 1933, AS AMENDED