definiens: means ( a)any Know - How that, as of the Effective Date, ( i ) is Controlled by Licensor pursuant to the ExistingLicenses or the Penn Sponsored Research Agreement or pursuant to Licensor ’s ownership thereof and(ii ) is reasonably necessary for the use, sale, offer for sale, or import of Licensed Products in the Field, including that which is set forth on Exhibit B ; and ( b)if a specific disease indication is added to the Field pursuant to Section 2.4, any Know - How that, as(x ) of the Effective Date or ( y ) if the added disease indication is one of the indications set forth onExhibit D, as of the date on which such disease indication is added, ( i ) is Controlled by Licensorpursuant to the Existing Licenses or the Penn Sponsored Research Agreement or pursuant toLicensor ’s ownership thereof, ( ii ) is directed to the specific disease indication that is added, and ( iii ) isreasonably necessary for the use, sale, offer for sale, or import of Licensed Products in the addedspecific disease indication in the Field;provided that will not include any Manufacturing Technology other than Triple - TransfectionKnow - How that otherwise falls within clause ( a ) or ( b ) above ; provided further that will notinclude any patents or patent applications