definiens: means the Materials in existence at the Effective Date and which are : ( a ) CHK1 Inhibitors first synthesised at ICR ’s Cancer Therap eutics Unit ( whether or not specifically exemplifie d in a Licensed Patent ) ; and ( b ) described in Schedul e 3 . To the extent that any Non - Compound Materials exist at the date of this Agreement which : ( i ) rela te to the Licensed Know How ; and ( ii ) are not reasonably available from stock from a commercial s upplier ; and ( iii ) after the Effective Date, ProNAi reasonably requests for use by it or a Sub - Licensee in the further development and commercialisation o f the CHK1 Inhibitors licensed under this Agreement ; and ( iv ) are available at the time of the request, then Schedule 3 and this definition shall be amende d and said Materials will be provided to ProNAi at no cost