definiens: means ( a ) that certain Sponsored Research Agreement entered into between Licensor and The Trustees of the Unive rsity of Pennsylvania, effective on February 24, 20 09, as amended by Amendment No . 1, effective February 24, 2010, Amendment No . 2, dated March 31, 2010, Amendment No . 3, dated December 31, 2010, Amendment No . 4, effective December 31, 2011, Amendment No . 5, effective April 1, 2012, Amendment No . 6, ef fective December 31, 2012, Amendment No . 7, effecti ve January 1, 2014, and Amendment No . 8, effective Mar ch 15, 2014 ; ( b ) that certain Sponsored Research Agreement entered into between Licensor and The Tru stees of the University of Pennsylvania, effective November 1, 2013 ; and ( c ) any additional amendments to either ( a ) or ( b ) effective prior to the Grant Date for a Licensed Indication