definiens: shall mean those Pa tent Rights as of the A&R Agreement Effective Date or thereafter during the Term that are owned by, li censed to or otherwise held by [COMPANY] or any of its Affiliates ( other than Regeneron Patent Rights and Patent Righ ts included in Joint Inventions ) with the right to license or sublicense the same and which include at least one ( 1 ) claim which, absent a license from [COMPANY] or an y of its Affiliates, would be infringed by the research, dev elopment, manufacture, commercialization or use by Regeneron of any IO Antibody or any IO Target Profi le ( or any Target contained therein ) that is or was, at any time during the Term, an IO Discovery Program Antib ody or IO Discovery Program Target Profile ( or any Target contained therein ), respectively, including any Refused Candidate that was, at any time during the Term, an IO Discovery Program Antibody