definiens: means tm : specificntions $ C\ forth Agreement, pursuant to which ROCIIE shall mllIluf.cture the under this Agreement, which specifications may be modified from time to time upon request of GPRO, subject to the wriuen COl\SO'lt of ROCHE, such consent nol to be unreasonab ly withheld, conditioned or delayed . ROCHE acknowledges thai il is ...... are thai GPRO is likely 10 request modification of the Specifications from time - Io - time in conneetion with GPRO 's developmen l oflhe HPV TMA Test Kits and prior 10 l1IIy Finl Comme«:ial Sale thereof, us mel1lls '' Tl1U'Iscriplion·Metliated Amplification ", a lranscription·based process for amplifying . DNA or RNA target source . TMA comprises ft substantially continuous and isothc : rinal process of genenting multiple RNA copies of the tlltget sequence or its CQIllplemen t. It is expressly understood that the heating of target RNA to relax the mole<:ule prior-10 the Il'InSCription - based process can comprise a step in Further, it is expressly understood Ihat a transcription·based process, lIS described herein, that begins with a single stnlnded DNA or RNA target sequence or a double slmnded DNA target sequence includes no more than two cycles ofhcal denaturation and primer e)[II:118ion, ernplo ) ' ! ! only one pritnl,% in tbe first primer extension step, and produces a double stranded promoter sequc : oce is included within the meaning of '' TMA, '' Finally, it is expn : s5ly understood and agreed that the TMA process is not polymerase chain reaction ( ) amplification, namely the amplifiClltion of a nucleic acid sequence and the complement of that sequence by more than tWQ cycles of d~'1IIturalio n of a double stnmded nucleic acid, annealing and extension of two primers, wherein the sequence and its complement are rcpcPledly sepamlcd, each $ Cparated strand servCII as I template for primer extension and thc resulting double stranded nucleic acid is used in further cycles of denaturation, annealing and extension ofprilflClS