definiens: shall mean the United States and foreign patents and patent applications relating to the APCgene and/or the p53 gene and licensed ( with the right to grant sublicenses ) to [COMPANY] pursuant to the JHU LicenseAgreement together with patents arising therefrom and any extensions, registrations, confirmations, reissues, divisions, continuations or continuations - in - part, re - examinations or renewals thereof, including without limitationthe patents and patent applications listed in Appendix A hereto ( which may be updated from time to time to includesuch additional patents and patent application that may arise therefrom ) ; provided, however, that Gene Patent Rightsexpressly excludes any claims of such patents and patent applications that fall outside of the Field, including, without limitation, claims to antibodies, to the treatment, prevention or remedying of a gene deficiency, to purifiedproteins, or to DNA sequences other than those sequences that correspond to the p53 gene and the APC gene;provided further that DNA sequences which are ( i ) immediately adjacent to the p53 or APC genes and ( ii ) necessaryto the use of the p53 or APC genes, respectively, in the Field shall be considered within the Gene Patent Rights