definiens: shall mean any product comprising a Biologic or Compound that isdirected to or against, or incorporates or is derived directly from, a Committed Lead Targetfor which [COMPANY] has exercised its Selection Option as provided in Section 3.4.4(a ), a GSKAlternative Committed Lead Target for which [COMPANY] has exercised its Selection Option asprovided in Section 3.4.4(a ), or a [COMPANY] Alternative Committed Lead Target which GSKsubstituted for such Committed Lead Target pursuant to Section 3.4.4(e ), and : ( a ) which isCovered by one or more Valid Claims included within the FivePrime Background Patents, FivePrime Collaboration Patents or Joint Patents ; or ( b ) which was directly based upon, ordirectly incorporated or incorporates FivePrime Background Know - How, FivePrimeCollaboration Know - How or Joint Know - How . Licensed Product shall also include anyCombination Product . For the aggregation of Net Sales for the purpose of determining theapplicable royalty rate under Section 6.4, all Combination Products and single agentLicensed Products comprising the same Biologic or Compound ( as the case may be ) shall beconsidered the same Licensed Product, regardless of the formulation, dosage strength, routeof administration, packaging or product indication thereof or any other active ingredient(s)contained therein