definiens: means all Know - How Controlled by [COMPANY] as of the Effective Date or during theTerm which both ( a ) relates to the Cyclodextrin System and/or [COMPANY] ’s research and development of OtherLicensed Products or IT-101 and ( b ) is necessary or reasonably useful to ( i ) conduct research and development on theCyclodextrin System, including making improvements thereto, or ( ii ) research, develop, make, have made, use, market, offer to sell, distribute, sell and/or import the Other Licensed Products or IT-101 . Without limiting thegenerality of the foregoing, Licensed Know - How shall include all Know - How developed, applied or acquired by Calandoprior to the Effective Date that ( A ) pertains to the use of the Cyclodextrin System, ( B ) is a process for manufacturingthe cyclodextrin polymer, or precursors thereto, employed in the Cyclodextrin System, ( C ) is a process for conjugatingor complexing therapeutic agents to the cyclodextrin polymer employed in the Cyclodextrin System, or ( D ) is datagenerated by [COMPANY] in its research and development of the Other Licensed Products or IT-101