definiens: means any event, condition, change, circumstance, developmentor state of facts, individually or in the aggregate, that has, or could reasonably be expected to have amaterial, adverse effect on the Acquired Assets, but excluding the events or effects of : ( i ) changes to thepharmaceutical industry and markets in which Purchaser or Seller operate, to the extent such changesdo not have a disproportionately adverse effect on the Acquired Assets ; ( ii ) changes in the UnitedStates, United Kingdom or world financial markets in general ; ( iii ) changes arising in connection withearthquakes, hostilities, acts of war, sabotage or terrorism or military actions or any escalation ormaterial worsening of any such hostilities, acts of war, sabotage or terrorism or military actions existingor underway as of the date hereof ; ( iv ) any action taken by Purchaser or its Affiliates with respect to thetransactions contemplated hereby or with respect to an Acquired Asset ; or ( v ) any effect resulting fromthe public announcement of this Agreement, compliance with terms of this Agreement or theconsummation of the transactions contemplated by this Agreement