definiens: means all Know - How and Patent Rights now or in the future owned or licensed byAlnylam or its Affiliates that relate to RNAi technology, products or processes, including ( a ) the general structure, architecture, or design of nucleic acid based molecules which engage RNAi mechanisms in a cell ; ( b ) chemicalmodifications of nucleic acids ( including any modification to the base, sugar or internucleoside linkage, nucleotidemimetics, and any end modifications ) which do not abolish the RNAi activity of the nucleic acid molecules in ( a);(c ) manufacturing techniques for the nucleic acid based molecules or chemical modifications of ( a ) and ( b ) ; and ( d ) alluses or applications of nucleic acid based molecules or chemical modifications in ( a ) or ( b ) ; but excluding Patents whichrelates solely to ( i ) a specific Target or smallPage 72 of 93, Schedule B group of Targets ; or ( ii ) delivery technologies which may be broadly employed for delivery of nucleic acid basedmolecules