definiens: means : all research, preclinical, process development and manufacturing activities that are necessary or desirable for ZGI 's filing of an IND with the US FDA for the IL-21 Protein and that take place between January 1, 2003 and ZGI 's filing of such IND ( or such earlier date that the IL-21 Program is terminated pursuant to SECTION 3.1(c ), 8.2, 8.3, 8.4, 8.5 ot 8.6 ) . The key activities for the lL-21 Program established by ZGl are summarized in Exhibit A. Promptly after execution and delivery of this Agreement, the Joint Project Team will create a detailed joint work plan, approved by the Joint Steering Committee, containing activities with agreed deliverables, budget ; · and time lines up to the .filing of such IND, that may be amended from time to time by mutual agreement in writing between the parties .