definiens: shall mean all Inventions which are conceived, reduced to practice, or created : ( a ) solely by NUVE LO or its Permitted Recipients during the term of this Agreement ; or ( b ) by BPS or its Permitted Reci pients in the course of performing BPS ’ obligations under this Agreement either solely or jointly with NUVELO : ( i ) which embody modifications or improvements to the Drug Product or Bulk Drug Subst ance ; or ( ii ) are methods of manufacture [ * ] manufacture of the Drug Product or Bulk Drug Substance . NUVELO Inventions are solely owned by NUVELO, and BPS assigns all right, title a nd interest it may have in and to NUVELO Inventions to NUVELO . NUVELO has the right, but not the obligation, to seek patent and any other form of applicable intellectual property protection, at its sole expense, for any NUVELO Inventions