definiens: means, with respect to a Licensor, all Know - How Controlled by such Licensor on the EffectiveDate or during the term of the Regulus License Agreement that relates to ( a ) miRNA Compounds or miRNA Therapeuticsin general, ( b ) specific miRNA Compounds or miRNA Therapeutics, ( c ) chemistry or delivery of miRNA Compounds ormiRNA Therapeutics, ( d ) mechanism(s ) of action by which a miRNA Antagonist directly prevents the production of aspecific miRNA, or ( e ) methods of treating an Indication by modulating one or more miRNAs ; provided, however, that ineach case, ( i ) for any such Know - How that include financial or other obligations to a Third Party, the provisions of theRegulus License Agreement will govern whether such Know - How will be included as Licensed Know - How and(ii ) Licensed Know How does not include manufacturing technology ( including but not limited to analytical methods )