definiens: means any of the following, as applicable : a ) the research and Development program for JTX-2011 or any other Collaboration Candidates Specifically Directed to ICOS that are I mmune Activators conducted by Jounce ( including applicable Program - Specific Reagents ), w hether or not pursuant to the JTX-2011 IDP, as further described in Section 2.1.2, and all other Immune Activator activities conducted under the Collaboration with respect to ICOS ( the ) ; provided, however, that any research and Development program for any Collaboration Candidates Specifically Directed to ICOS that are Immune Suppr essors and applicable Program - Specific Reagents conducted by Jounce shall be included in t he Collaboration as an ; b ) the research and Development program for JTX-4014 or any other Collaboration Candidates Specifically Directed to PD-1 that are I mmune Activators conducted by Jounce ( including applicable Program - Specific Reagents ), w hether or not pursuant to the JTX-4014 IDP, as further described in Section 2.1.3, and all other Immune Activator activities conducted under the Collaboration with respect to PD-1 ( the ) ; provided, however, that any research and Development program for any Collaboration Candidates Specifically Directed to PD-1 that are Immune Suppr essors and applicable Program - Specific Reagents conducted by Jounce shall be included in t he Collaboration as an c ) each research and Development progr am for Collaboration Candidates and Development Candidates Specifically Directed to the Macrophage Targets that are either Immune Activators or Immune Suppressors, as applicable, conducted by Jounce ( including applicable Program - Specific Reagents ), whether or not pursuant to the IDP for such Collaboration Target, as further described in Section 2.1.4, and all other a ctivities conducted under the Collaboration with respect to the Macrophage Target, including an y applicable Program - Specific Reagents ( each such research and development program, includ ing each Bundled Macrophage Program, a )