definiens: shall mean a committee of six members, three of whom will be designated in writing by each of Pen west and [COMPANY] . The Alliance Committee as of the date of this Agreement shall have six members, as follows : Dr. Deborah Fox, Ms. Jennifer Good and Dr. Anand Baichwal, designated by [COMPANY], and Dr. David Lee, Mr. Peter Lankau and Ms. Caroline Manogue designated by [COMPANY] . If at any time a vacancy occurs ( whether due to death, disability, resignation, removal by a party of its designee by written notice to the other party, or otherwise ), the vacancy will be filled as soon as is reasonably practicable by designation by the party that originally designated the prior incumbent . In the meantime, the Alliance Committee shall continue to function with its remaining members, provided that any Committee Action described in Section 1.10 hereof will continue to require the consent of at least four members