definiens: means all Patents that ( a ) are Controlled by Sanga mo or its Affiliates as of the Effective Date or anytime duri ng the term of this Agreement, and ( b ) claim or cov er the Modified Rats or Aire - KO Rats or the use of the Modified Rats or Aire - KO Rats . ” 1.3 The following new Section 1.26 shall be added to re ad in its entirety as follows : means the rat autoimmune regulator gene defined by the following NCBI gene ID : [ * * * ] . ” 1.4 The following new Section 1.27 shall be added to re ad in its entirety as follows : means ( a ) a rat having a genomic modification at the Aire Locus, which genomic modification ( i ) was created using ZF Ps pursuant to a research license from Sigma ’s sublicensee Sage Labs, Inc. and ( ii ) results in eli minated or significantly reduced expression of the Aire Gene or the expression by the Aire Gene of a protei n with significantly reduced function, and ( b ) any progeny thereof . ” 1.5 The following new Section 1.28 shall be added to re ad in its entirety as follows : means the location of the Aire Gene in the rat geno me defined by the following NCBI reference location : [ * * * ] . ” 1.6 The following new Section 1.29 shall be added to re ad in its entirety as follows : means that the therapeutic entity is not introduce d artificially into the animal but rather is a product of endogenous proces ses that occur within the animal ( albeit geneticall y modified ) and whose exact chemical structure could not have been predicted a priori ( e.g., an antibody ) . ” 1.7 The following new Section 1.30 shall be added to re ad in its entirety as follows : means any OMT Product wherein the relevant Modifie d Rat is a DKO Rat . ” 1.8 The following new Section 1.31 shall be added to re ad in its entirety as follows : means ( a ) a rat that ( i ) is the progeny, whether d irect or indirect, from the breeding of a Modified Rat described in Section 1.10(a ) with a Aire - KO Rat, ( ii ) has both ( 1 ) the genomic modification at the Target that is found in such Modified Rat and ( 2 ) the genomic modification at the Aire Locus that is found in such Aire - KO Rat, and ( iii ) is a Modified Animal wherein the Discovery or creation of a new * * * CONFIDENTIAL PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION 2 DB2/ 30701959.1 NOTE : Portions of this Exhibit are the subject of a Confidential Treatment Request by the Registrant t o the Securities and Exchange Commission ( the )