definiens: means all Patents ( including all claims and the entire scope ofclaims therein ) Controlled by Regulus or its Affiliates on the Effective Date and/or at any time thereafterduring the Term, in each case claiming : ( a ) the composition of matter of a Lead Compound or Product;(b ) methods of using a Lead Compound or Product ; or ( c ) the manufacture of a Lead Compound, butexcluding in each case : ( 1 ) Patents that include claims that are directed to subject matter and have a scopethat is applicable to microRNA Compounds in general and do not exemplify or claim Lead Compounds orProducts and ( 2 ) Patents that do not exemplify or claim Lead Compounds or Products and that includeclaims directed to the identification or isolation of microRNAs that are not Collaboration Targets, or to theproduction, composition, or use of microRNA Compounds that are not Lead Compounds or Products(which Patents Controlled by Regulus or its Affiliates described in ( 1 ) and ( 2 ) will, for clarity, be consideredto be Regulus Core Technology Patents ) . For clarity, any Regulus Program Patent satisfying the definitionabove, will be considered a Regulus Product Specific Patent . The Parties agree that there are no RegulusProduct Specific Patents as of the Effective Date