definiens: means the date of execution by l. ICE\JSLF of the last to be completed written license agreement with both of A, mg ~ n- lnc ...... and J}igyi ~ D, J)JL,8,ll ( or any transferee ofeither such party ofthe patents described in this Section l .1 ) granting LICENSEE exclusive rights under patents controlled by such entities necessary for the worldwide clinical use and commercial sale of Kineret!t_(anakinra ) for ophthalmic indications ; provided, that, ifUC.EN SEE reasonably determines in good faith that a single license agreement with either Amgen, fnc . or B!pvitrum _ j, il is required for the worldwide clinical use and commercial sale ofJ.s.inei.a " .(anakinra ) for ophthalmic indications, it shall provide LICENSOR with prompt written notice of such determination and the Additional License Agreements Milestone shall be deemed to have been achieved as of the date of execution by LICENSEE of the license agreement that is required