definiens: means all Patents Controlled by [COMPANY] or its Affiliates on the Effective Date or atany time during the Agreement Term Covering ( a ) the composition of matter of a Product, ( b ) methods of using a Product, or ( c ) an oligonucleotide compound that specifically modulates expression of TTR via the binding, partially or wholly, ofsuch compound to RNA that encodes TTR ; provided, however, that Patents Controlled by [COMPANY] or any of its Affiliates thatinclude any claims that are directed to ( i ) subject matter applicable to oligonucleotide compounds or products in general or(ii ) an oligonucleotide compound that does not specifically modulate expression of TTR via the binding, partially or wholly, of such compound to RNA that encodes TTR, will not be considered [COMPANY] Product - Specific Patents, and in the case of ( i)and ( ii ), such Patents will be considered [COMPANY] Core Technology Patents . The [COMPANY] Product - Specific Patents as of theEffective Date include the Patents set forth on Appendix 3