definiens: shall mean, with respect to the eﬀorts to be expended by a Party with respect to any objective, thosereasonable, good faith eﬀorts to accomplish such objective as such Party would normally use to accomplish a similar objective under similarcircumstances ; Licensee will be deemed to have exercised Commercially Reasonable Eﬀorts if Licensee has exercised those eﬀorts normally used by apharmaceutical or biotechnology company of similar size and similar resources, with respect to a compound, product or product candidate, as applicableof similar modality, which compound, product or product candidate is of similar market potential in such country, and is at a similar stage in itsdevelopment or product life cycle, taking into account all relevant factors in eﬀect at the time such eﬀorts are to be expended . It is expressly understoodthat the use of Commercially Reasonable Eﬀorts may result in ceasing the development, Regulatory Approval or commercialization of Products . Further, to the extent that the performance of a Party ’s obligations hereunder is adversely affected by the other Party ’s failure to perform its obligations hereunder, the impact of such performance failure will be taken into account in determining whether such Party has used its Commercially Reasonable Eﬀorts toperform any such affected obligations