definiens: means the conduct of activitiesrelating to the generation of Antibodies, Antisense Compounds and Proteinsrelating to Program Targets that have not become Opt - out Targets and theidentification, characterization, selection, optimization and research ofProgram Antibodies, Program Antisense Compounds and Program Proteins prior totheir designation as Collaboration Products . Biotherapeutics Research mayinclude, without limitation, ( a ) the expression of Proteins comprising ProgramTargets, ( b ) the generation of Program Antibodies that bind to Program Targets,(c ) the generation of Antisense Compounds that hybridize with mRNA encoded byProgram Targets or otherwise interfere with translation or transcription of suchmRNA, ( d ) the development of assays for Program Antibodies, Program AntisenseCompounds and Program Proteins to, inter alia, confirm the activity of suchProgram Antibodies, Program Antisense Compounds or Program Proteins, and ( e ) theoptimization of such Program Antibodies, Program Antisense Compounds or ProgramProteins, as the case may be, in each case with the objective of identifyingProgram Antibodies, Program Antisense Compounds and Program Proteins that aresuitable for Development and meet the criteria required for designation asCollaboration Products