definiens: means, with respect to a Product, Patent Rights C ontrolled by a Party or any of its Affiliates on or after the Effective Date claiming ( i ) the specific composition of matter of such Prod uct, or ( ii ) methods of using such Product as a prophylactic or therapeutic, in each case to the extent necessary t o Develop, Manufacture or Commercialize a Product ; provided however, Patent Rights Controlled by [COMPANY] or any of its Affiliates that ( a ) include claims that are directe d to subject matter applicable to ASOs or products in general, or ( b ) include an ASO, the sequence of which targets t he RNA that encodes Factor B and ASOs that do not t arget the RNA encoding Factor B, will not be considered Produ ct - Specific Patents, and in the case of ( a ) and ( b ), such Patent Rights will be considered [COMPANY] Core Technology Pat ents