definiens: shall mean each of the following six ( 6 ) NNR drug discovery, research and development programs, as characterized by both ( i ) the stated Indication and ( ii ) the Protein Target Profile ( as may be changed from time to time solely as expressly provided in this Agreement ) or ( iii ) solely in the case of Pain I, specific Collaboration Compounds : EXECUTIO N VERSION -22 - Program Indication Protein Target Profile Specific Collaboration ComQounds Pain I -- TC-2696 and TC-6499 Pain 2 a4p2 * + a4p2a5 + a7 --Parkinson 's disease a4p2 * + a7 + a6 * --Smoking cessation a4p2 * + a7 + a6 * --Obesity a4p2 * + a7 + a6 * --Addiction a4p2 * + a7 + a6 * --*indicates the presence of yet to be defined NNR Subunits The Parties acknowledge and understand that the goal of each Program is to identify and develop a different new chemical entity ( NCE ) with a different Mechanism of Action, which would result in a total of at least six ( 6 ) NCEs