definiens: shall mean, with respect to a PRESENTATION for any period, the gross invoiced sales price for all quantities of such PRE SENTATION sold by SALIX, its AFFILIATES and license es in the TERRITORY during such period, less ( i ) sales taxes or other taxes included in the gross invoice price ; ( ii ) actual shipping and insurance costs paid to a THIRD PARTY ; ( iii ) actual credits or refunds for re turned or defective PRODUCTS ( but excluding any credits or re funds for quantities of such PRESENTATION in connection with any RECALL of such PRESENTATION, un less, and to the extent, that such RECALL results from a breach of this Agreement by EISAI ) ; ( iv ) tra de discounts and quantity discounts or retroactive price reductions ; and ( v ) rebates, credits, and chargebac k payments ( or the equivalent thereof ) actually gra nted to managed health care organizations, wholesalers, or to federal, state, local and other governments, inc luding their agencies, purchasers, and/or reimbursers, or to tra de customers, calculated in accordance with GAAP an d consistent with SALIX ’s past practice . All PRODUCTS will be considered upon first use, shipment, invoicing or receipt of payment therefor, whichever shall first occur . Notwithstanding the foregoing, NET SALES shall not include, and shall be deemed zero w ith respect to, ( i ) the actual distribution of SAMP LES as provided herein ; or ( ii ) all PRODUCTS provided for clinical trials or research purposes at cost or at no charge