definiens: means, with respect to a country or jurisdiction in the Territory, the first indication for whichLicensee pursues Marketing Authorization for a Product in such country or jurisdiction using the TXMD Clinical Data asthe basis for obtaining such Marketing Authorization . Upon the granting of the first such Marketing Authorization insuch country or jurisdiction by the applicable Regulatory Authority, the indication described in such MarketingAuthorization for a Product in such country or jurisdiction as specified in the applicable Product Labeling for suchProduct shall thereafter be the Initial Indication . As of the Effective Date, the Initial Indication for the TX-001 Product isanticipated to be comprised of hormone replacement therapy for oestrogen deficiency symptons in post - menopausalwomen . As of the Effective Date, the Initial Indication for the TX-004 Product is anticipated to be comprised of thetreatment of dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause