definiens: shall mean ( i ) ARRY-403, ( ii ) all small molecules tested for glucokinaseactivation by [COMPANY] prior to the Effective Date, or made and tested by [COMPANY] in the course of the DiscoveryProgram, which show or showed some activity as activators of glucokinase in such testing ( but, for clarity, excluding intermediates of such compounds that were not themselves tested and molecules that were testedbut did not show activity as activators of glucokinase ), ( iii ) any other small molecule that binds to andactivates glucokinase and [ * * * ], [ * * * ], or ( iv ) any other small molecule that, as its primary and intendedmechanism of action for therapeutic effect ( intended by the Party, its Affiliate or Third Party researching, developing or commercializing such small molecule ), binds to and activates glucokinase