definiens: shall mean, with respect to a particular Screening Assay, a Target that : ( a ) when suchTarget or a fragment thereof was tested by FivePrime in such Screening Assay pursuant tothe Research Program, satisfies the threshold for activity or inhibition in RespiratoryDiseases and reproducibility as determined by the Working Group ; ( b ) is not a ReservedTarget ( subject to Section 3.4.1(d)(i)(6 ) ) ; and ( c ) is not a Third Party Target . A Hit shallcease to be a Hit when it becomes an Offered Hit or Reverted Target, in each case pursuantto Section 3.4.1(b ) or Section 4.4.5(c)(ii ) . The Parties acknowledge that a Target thatbecomes a Reverted Hit for one Screening Assay is not precluded from becoming a Hit in asubsequent Screening Assay, so long as such Target has not in the interim become aReserved Target subject to Section 3.4.1(d)(i)(6 ) ), or a Third Party Target