definiens: means any Improvement of a Phage L - Display process or any other technology, process, or methodology that is developed by or on behalf of Licensee, its Affiliates or sublicensees and that satisfies all of the following criteria : ( a ) is first reduced to practice, or described in a patent application, publication, or abstract within~~ ~~~~i'yearsdafter the Effective Date ; provided, however, that upon the request of CAT at any time during thek~~~d5l}.,yeaF period following the date that is ~ me(9 ) years';from the Effective Date and upon demonstration by CAT of good commercial, technical, or legal reasons for extension of the foregoing t ~ l:¥~(lO).:yearf period, the Parties agree to negotiate in good faith the potential extension of such period for one ( 1 ) additional!tiVe(5}.yea ~ period, with the consent by Licensee to such extension not to be withheld absent demonstration of good commercial, technical, or legal reasons for opposing such extension ; ( b ) may not lawfully be Exploited without a license to one or more Valid Claims within the CAT Licensed Patents ; ( c ) is not a human therapeutic or diagnostic product, a manufacturing method applicable to that product, or a method of using that product ; and ( d ) is not claimed in or covered by any Patent Controlled by Licensee and is not an improvement, modification or adaptation of any such invention ; and ( e ) does not relate to any BiTE Product . ] 1.26 means a marketing approval application filed with the European Medicines Evaluation Agency or a Biologics License Application filed with the FDA, and any corresponding applications in other countries or territories . r 1.27 means the ~ tlit ~ dgtates of America, the United ~gdom, France, Germany, Italy, Spain, and Japan . J 4 1.28 means the approval of an MAA for a Licensed Product and any pricing and reimbursement approvals to the extent the applicable Regulatory Authorities in a country require a pricing or reimbursement approval prior to the marketing and sale of such Licensed Product in such country