definiens: means any gene target that ( i ) as of the Effective Date, ( y ) has not been encumbered by Isis under anagreement with a Third Party that would prevent Isis from granting [COMPANY] Idec the license under Section 4.1.1 of thisAgreement with respect to such gene target, and ( z ) has not yet achieved Target Sanction status, and ( ii ) as of the EffectiveDate or during the Research Term, the expression or activity of the gene in neurons is demonstrated to have an association toany one of the following ( each of ( a ) through ( e ) below, a ): [ * * * ] For purposes of clarity, [ * * * ] are expressly excluded from the above - listed [ * * * ] and therefore any gene target that has as itsprimary disease association an association to [ * * * ] will not be a Neurology Target, and any [ * * * ] will not be a Product underthis Agreement . In addition, [ * * * ] or [ * * * ] are expressly excluded from the above - listed [ * * * ] and therefore any gene targetthat has as its [ * * * ] will not be a Neurology Target