definiens: means, for DOT1L or [ * * ], the activities performed or to be performed bythe Parties, their Affiliates and Sublicensees, in accordance with the applicable Development Plan and the approvedbudget and under the overall direction of the JDC, to Develop Licensed Compounds and Licensed Products Directedto such Target after ( a ) in the case of DOT1L, such Target became a Selected Target pursuant to the OriginalAgreement, and ( b ) in the case of [ * * ], such Target becomes a Selected Target, and in each case of ( a ) and ( b),related Diagnostic Products, in the Field during the applicable Development Term . For clarity, a Shared DevelopmentProgram as to which EPIZYME exercises an EPIZYME Post - EOP1 Clinical Opt - Out pursuant to Section 2.5 or anEPIZYME Late Stage Opt - Out pursuant to Section 2.6 shall constitute a