definiens: shall mean ( a ) an Antigen that is or becomes the subject of Refusal Rights which a Party has granted or is contractually required to grant to a Third Party as a result of an agreeme nt between such Party ( or any of its Affiliates ) and a Third Party that was enter ed into prior to the Effective Date ( regardless of whether the Antigen(s ) with respect to which the Third Party shall have Refusal Rights is selected b y such Third Party prior to the Effective Date ), without giving effect to any r enewal, extension, revision, amendment or other modification to such agreement e ntered into after the Effective Date that provides to the Third Party ( i ) a right to designate an additional number of Antigens to which such Third P arty shall have Refusal Rights ; or ( ii ) that provides for any extension of time for such Third Party to exercise its Refusal Rights ( other than any extensi on provided for in such agreement as it exists as of the Effective Date ), o r ( b ) an Antigen that [COMPANY] has selected as an In - House Target prior to the Eff ective Date, as confirmed by the Shared Exclusive Antigen List ; provided, howeve r, that in the case of any Antigen selected by [COMPANY] as an In - House Target pri or to the Effective Date, such Antigen shall be a ROFR Target only for the pe riod beginning on the Designation Date for such Antigen and ending on the [ * ] of such date, or such earlier date as such ROFR Rights are terminated in accordance with Section 4.3.3(e ) hereof, at which time such ROFR Target sha ll remain a [COMPANY] Reservation Target until the end of Reservation License Period or until [COMPANY] abandons such [COMPANY] Reservation Target pursuant to Section 5.4 he reof