definiens: shall mean, with respect to a given activity and a Party for a product or compound under this Agreement, the level of effort that would 6 [ ] = Certain confidenri _ 31 infonnarion contained in this document, highlighted and marked by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended . CONFIDENTIAL TREATMEflr . TREQUESTED UNDER 17 C.F.R. § § 200.80 ( b)(4 ) AND 230.406 generally be used by such Party to conduct such activity for a product or compound owned by it or to which it has rights, which is of comparable market potential, profit potential or strategic value to such Party and is at a similar stage in its development or product life, taking into account, without limitation, issues of safety and efficacy, product profile, the proprietary position, the then - current competitive environment for such product or compound ( and any individual agent comprising part of such product or compound ), the likely timing of the product 's or compound 's ( and any such individual agent 's ) entry into the market, the then­current market penetration, the return on investment potential of such product ( and any individual agent comprising part of such product ), the regulatory environment and status of the product ( and any individual agent comprising part of such product ), and other relevant scientific, technical and commercial factors, in each case as measured by the facts and circumstances at the time such efforts are due . For purposes of clarity, in determining Commercially Reasonable Efforts necessary to Distribute the Combination Product, such Commercially Reasonable Efforts would not necessarily require the launch or continued commercialization of the Combination Product in a given country