definiens: means the development plan to be established with respect to each Selected Collabora tion Combination pursuant to Section 3.1 hereof and 4 CONFIDENTIAL EXECUTION COPY containing the activities to be undertaken by Fovea to enable Fovea to deliver a Target Dossier in accordance with the terms of this Agreement . Without limiting the foregoing, the Detailed Development shall provi de for the following development steps for each Selected Collaboration C ombination, as applicable : ( a ) The Selected Collabor ation Combination shall enter formulation developme nt ; ( b ) If the Selected Colla boration Combination can be formulated for ophtha lmic use, it shall be advanced to ocular to lerability experiments ; ( c ) If the Selected Colla boration Combination has acceptable ocular tol erability properties, it shall be advanced to animal proof - of - concept efficacy models ; ( d ) If the Selected Colla boration Combination is efficacious in animal models it shall be advanced to ocular toxicity an d pharmacokinetic studies ; ( e ) If the Selected Colla boration Combination is tolerable, non - toxic, efficacious, and can be formulated for ophtha lmic use, it shall be advanced to a Phase I human toxicity / pharmacokine tic study ; and ( f ) If the Selected Colla boration Combination is non - toxic and has acc eptable pharmacokinetic properties in humans, all shall be advanced to a human proof - of - concep t study ( e.g. Phase IIa )