definiens: shall mean, with respect to each country in the Territory, ( 1 ) the gross amount invoiced for sales ofTYSABRI in such country by [COMPANY] Idec or any of its Affiliates to Third Parties, subject to Section 4.9, and ( 2 ) the netroyalty amount 6received by [COMPANY] Idec or any of its Affiliates with respect to sales of TYSABRI in such country pursuant to license orother agreements with Third Parties, subject to Section 4.9, less the following deductions, in each case ( A ) withoutduplication, ( B ) where applicable with respect to the gross amount invoiced, ( C ) as incurred in relation to sales ofTYSABRI following the end of the Stub Period, ( D ) as incurred in the ordinary course of business in type and amountconsistent with good industry practice and ( E ) except with respect to the uncollectible amounts on previously soldTYSABRI described in clause ( ii ) below and the pharmaceutical excise taxes described in clause ( v ) below, as determinedin accordance with, and as recorded in revenues under, United States Generally Accepted Accounting Principles : ( i)sales returns and allowances actually paid, granted or accrued on TYSABRI, including trade, quantity, prompt pay and cash discounts and any other adjustments, including those granted on account of priceadjustments or billing errors ; ( ii)credits or allowances given or made for rejection or return of, and for uncollectible amounts on, previously sold TYSABRI or for rebates or retroactive price reductions ( including Medicare, Medicaid, managed care and similar types of rebates and chargebacks ) ; ( iii)to the extent not already deducted or excluded from the gross amount invoiced, taxes, duties or othergovernmental charges levied on or measured by the billing amount for TYSABRI, as adjusted forrebates and refunds, which, for the avoidance of doubt, shall not include any tax, duty, or other chargeimposed on or measured by net income ( however denominated ), or any franchise taxes, branch profitstaxes, or similar tax ; ( iv)to the extent not already deducted or excluded from the gross amount invoiced, customs or exciseduties, sales tax, consumption tax, value added tax, and other taxes ( except income taxes ), as adjustedfor rebates and refunds ; ( v)pharmaceutical excise taxes ( such as those imposed by the United States Patient Protection andAffordable Care Act of 2010 ( Pub . L. No . 111 - 48 ) and other comparable laws ) ; ( vi)charges for freight and insurance directly related to the distribution of TYSABRI, to the extent notalready deducted or excluded from the gross amount invoiced, for sales of TYSABRI by [COMPANY] Idec orits Affiliates or permitted sublicensees to Third Parties in the Territory ; ( vii)credits for allowances given or made for wastage replacement for TYSABRI ; 7 ( viii)wholesaler and distributor administration fees ; and ( ix)other similar or customary deductions taken in the ordinary course of business or in accordance withUnited States Generally Accepted Accounting Principles