definiens: means any Antibody that ( a ) specifically binds Trem2 and a principal therapeutic mechanism ofaction of which is mediated as a result of such binding and ( b ) claimed in the Existing Patents or Licensor Program Patents or made by or onbehalf of Licensor or its Affiliates under this Agreement . Licensed Trem2 Antibody expressly includes the Antibody known by Licensor asAL002 and all backups to AL002, as described on Schedule 1.129 . For clarity, bispecific and multispecific Antibodies with at least one oftheir binding specificities and principal therapeutic mechanisms of action ( as described above ) directed to Trem2 and that are claimed in theExisting Patents or Licensor Program Patents or made by or on behalf of Licensor or its Affiliates under this Agreement shall also beconsidered Licensed Trem2 Antibodies