definiens: means ( 1 ) licenses granted by [COMPANY] before or aft er the Effective Date to any Third Party under the [COMPANY] Core Technology Patents, the [COMPANY] Manufacturing and Analytical Patents, or the [COMPANY] Manufacturing and Analytical Know - How ( but not unde r the [COMPANY] Product - Specific Patents ) to ( a ) use Oligonucleotides ( or supply Oligonucleotides to end users ) solely to conduct pre - clinical research, or ( b ) enable such Third Party to manufacture or formulate Oligon ucleotides, where ( i ) such Third Party is primarily engaged in providing contract manufacturing or services and is not primarily engaged in drug discovery, develo pment or commercialization of therapeutics ; and ( ii ) [COMPANY] d oes not assist such Third Party to identify, discov er or make a Compound or Product ; and ( 2 ) material transfer agre ements with academic collaborators or non - profit in stitutions solely to conduct non - commercial research