definiens: means the following with respect to salesby [COMPANY] or any sublicensee other than an Ex - U.S. Partner : in the event a Licensed Productis sold in the form of a combination product containing one or more active ingredients in-2-•addition to a Licensed Product, Net Sales for such combination product will be adjusted bymultiplying actual Net Sales of such combination product by the fraction Al{A+B ) ; where A isthe invoice price of a Licensed Product, if sold separately, and B is the invoice price of any otheractive component or components in the combination, if sold separately . If, on a country - by - country basis, the other active component or components in the combination are not soldseparately in said country, Net Sales shall be calculated by multiplying actual Net Sales of suchcombination product by the fraction AlC, where A is the invoice price of the Product if soldseparately and C is the invoice price of the combination product . If, on a country - by - countrybasis, neither a Licensed Product nor the other active component or components of thecombination product are sold separately in said country, Net Sales shall be determined by theParties in good faith . .'1.8 means those effortsconsistent with the exercise of prudent scientific and business judgment, as applied to otherpharmaceutical products of similar potential and market size by the Party in question