definiens: means [COMPANY] ’ proprietary tools, processes and methods for Protein Engineering that are covered or claimed by Patents or Know -How Controlled by [COMPANY], including without limitation ( i ) tools, processes and methods used to identify, select, optimize, isolate, modify, engineer and develop proteins, including enzymes, through the recombination, rearrangement and/or mutation of genetic material for t he creation of genetic diversity using any methods, including but not limited to bioinformatics, in silico, in vitro, and/or in vivo technologies, ( ii ) screening techniques, methodologies and/or processes of using the resulting genes and/or proteins, inclu ding enzymes, to identify and assess their potential utility, ( iii ) gene expression methods applicable in high throughput screening, ( iv ) techniques for cultivation of microorganisms, ( v ) techniques for producing, harvesting, and/or purifying proteins, inc luding enzymes, and ( vi ) bioinformatics methods and algorithms, including those known as,,, and ( in each case ( clauses ( i ) through ( vi ), for clarity, as used in Protein Engineering ) ; provided however that Cod exis Methods shall not include any Information, tools, processes or methods that are specifically related to, or are otherwise necessary for the Exploitation of, a Compound, Product, ROFN Compound or ROFN Product, as applicable