definiens: means, with respect to all Licensed Products, [ * ] ( b)Section 3.2.5 of the Option Agreement shall be amended by adding the following to the end of such section:“Notwithstanding the foregoing and notwithstanding the prohibition in Section 2.1.3 on the JRC ’s ability toamend the Initial Development Plan, [COMPANY] will deliver each proposed update with respect to the GI-6300 Program to [COMPANY] in the form of an amended Initial Development Plan with respect to the GI-6300Program ; and such proposed amended Initial Development Plan will be reviewed and adopted ( with suchmodifications agreed to by the JRC ) or rejected by the JRC ( with decisions of the JRC being resolved inaccordance with Section 2.1.3 ) and will not require the separate approval of the Parties . ” ( c)Section 4.4 of the Option Agreement shall be amended by adding the following to the end of such section:“Notwithstanding the foregoing or anything in this Agreement to the contrary, [COMPANY] will have no obligationsunder this Section 4.4 or any other provision of this Agreement to Develop any [COMPANY] DevelopmentCompounds or Licensed Products from the GI-6300 Program ; instead, [COMPANY] ’s obligations under thisSection 4.4 with respect to the GI-6300 Program will be limited to using Commercially Reasonable Efforts inCommercializing [ * ] [COMPANY] Development Compound or Licensed Product from the GI-6300 Program afterobtaining Regulatory Approval for a [COMPANY] Development Compound or Licensed Product in the GI-6300Program . ” ( d)Section 4.8 of the Option Agreement shall be amended by adding the following to the end of such section : Notwithstanding the foregoing or anything else in this Agreement to the contrary, ( a ) the provisions of thisSection 4.8 ( other than the first sentence hereof ) shall not apply to the GI-6300 Program ; ( b ) following theexercise of the [COMPANY] Program Option for the GI-6300 Program, [COMPANY] shall have no obligation to obtainany supply from [COMPANY] or a [COMPANY] authorized Third Party second source of supply ofCelgene ’s requirements for any [COMPANY] Development [ * ] = Certain confidential information contained in this document, marked by brackets, is filed with the Securities andExchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended