definiens: . Indication means a separate and distinct disease or medical condition ; provided that within the fieldof oncology, Indication means a cancerous condition resulting from a separate and distinct tumor type that is the basis for aseparate and distinct Marketing Approval . For purposes of clarity, examples of Indications within the field of oncologyinclude, but are not limited to : renal cell carcinoma, hepatocellular carcinoma, non - small cell lung cancer, prostate cancer, colon cancer, breast cancer, and cancerous conditions where treatment is based upon biomarker measurements independent ofthe cancer ’s tissue of origin . Indication shall have the same meaning whether a Licensed Product is used to treat patients aloneor in combination with other treatment modalities . Moving from one line of therapy to another within an Indication shall notbe considered to be a new Indication, a non - limiting example of which is moving from second line therapy to first linetherapy