definiens: with correlative meanings or to, means covalent chemical bonding of any REAGENT ( inc luding SELECTED REAGENT and including covalent chemical bonding through lin king groups ) with or to another material or materials . Such materials inclu de, without limitation, proteins, peptides, oligonucleotides, other biomole cules, small molecules, therapeutic agents ( including THERAPEUTIC AGENT ), d iagnostic agents, imaging agents and detectable labels . Additional ma terials that may be PEGYLATED include without limitation, polymers, lip osomes, films, chemical separation and purification surfaces, solid support s, metal / metal oxide surfaces and other surfaces such as, by way of exam ple but not limitation, those on implanted devices, and equipment, where a REAGENT is covalently chemically bonded to one or more reactive molecules on the surface of such device or equipment . shall include the synthesis, derivatization, characterization, and modification of PEG for Page 10 of 70 such purposes, together with the synthesis, derivat ization, characterization, and modification of the raw mater ials and intermediates for the manufacture of REAGENTS ( including SELECTED REAGENT ) or products ( including SELECTED PRODUCT ) incorporating such REA GENT by means of covalent chemical bonding, and all methods of makin g and using each and all of the foregoing