definiens: means each Collaboration Candidate that is not a Terminated Compound that isdetermined by the JRC or [COMPANY] during the Research Program Term or the Tail Period to satisfy the Active+Criteria ( unless and until ( a ) [COMPANY] challenges such determination pursuant to Section 4.3.2 and ( b ) suchCollaboration Candidate is finally determined by the ESC ( in accordance with Section 2.1.5(c)(iii ) ) or, if applicable, anExpert ( in accordance with Section 14.3 ) to not satisfy the Active+ Criteria ), including any salt form, polymorph, crystalline form, hydrate, solvate or formulation thereof . For purposes of clarity, all Active+ Compounds are alsoCollaboration Candidates . Notwithstanding the foregoing, unless the Parties otherwise agree in writing, theCompounds known to [COMPANY] as of the Execution Date as [ * * * * * * * * ] and, [ * * * * * * * * ], including any salt form, polymorph, crystalline form, Prodrug, metabolite ( other than any such metabolite that is an Excluded ZoneCompound ), hydrate, solvate or formulation thereof, shall not be Active+ Compounds