definiens: means a TCR based therapy customized for each patient in that such therapy is developed on apatient - by - patient basis by modifying T cells from the respective patients, and meets all of the following criteria : ( a ) patient sample iscollected and analyzed ; ( b ) based on the results from ( a ), the TCRs for the individualized therapy are either [ * * * ] to different targets ( ) or are [ * * * ] in an individual patient ’s T cells [ * * * ], ( c ) T cells Directed To a Selected Target are treated unbiasedly with thesame methods as other cancer - targeting T cells which are isolated from and reintroduced into the same patient ; ( d ) no effort will be madewith the explicit purpose to specifically target, amplify, or enrich the Selected Target in the patient sample or identify, stratify, or pre - screen apatient using a diagnostic specifically aimed at the Selected Target and ( e ) at least one of the TCRs in the therapy is Directed To a SelectedTarget