definiens: mcans Avccia Limited . Section 1.4 means tbe agreement betwccn WUN and Avecia for the manufacture orrFXW daled August 15.200 I, as arucndod by First, Second, Third, Fourthand fifdl Amendments and Programme Amendment Orders, ineludiu PAO 4.2 dated March 200 I relating tot3,OOO lileljfeml entation lit wiUt full processing of an approximat 300 - te aliquot . Sedion 1.5 . ItAventis Agreelllent " meaus the ExclUSIVe Patent Liccllse Agrccmeut bei . WCCll Aveutis Ochring GmbH ( now known as ZLB HoldlU & GmbH, HAvenHs " ) and ZGEN dated December 18,2002, as amended by a First Amendment dated December 8, 2003 and a Second Amendment dated October I, 2004