definiens: shall mean ( i ) the gen eration and development of Mutant Mice by [COMPANY] at its internal resea rch facilities and ( ii ) the use of Mutant Mice and Progeny, including the breeding thereof, by [COMPANY] and, subject to the terms and condit ions of Sections 2.2 and 2.3, by [COMPANY] 's Academic Collaborators and Cont ract Service Providers, at the internal research facilities of [COMPANY], such Academic Collaborators or Contract Service Providers, in each case fo r research purposes only, including research directed toward the discove ry, development and commercialization of human therapeutic and dia gnostic products . The Field of Use shall specifically exclude ( i ) the deve lopment of a library of mouse embryonic stem cells, ( ii ) the sale, lease or other transfer for consideration of any Mutant Mouse or Progeny, ( iii ) the use of any Mutant Mouse or Progeny for consideration ( including, without limitation, use of any Mutant 1 < PAGE > Mouse or Progeny in contract testing services ) and ( iv ) the generation, development, manufacture or importation of any Mutant Mouse or Progeny for any of the foregoing . The Field of Use shall f urther exclude the generation, development and use of ( i ) any tra nsgenic mouse containing unrearranged human immunoglobulin DNA or inact ivated murine immunoglobulin DNA, ( ii ) any mouse as a model for Alzheimer 's disease based upon ( beta)-amyloid precursor protein coded for by the App gene or mutated forms thereof, ( iii ) any immunomodified mouse model for the study of transplanted human cells or ( iv ) any transgenic immunomodif ied mouse for use in studies of human allergenicity of non - therapeutic prot eins or peptides and in research directed toward the development of no n - therapeutic proteins or peptides that demonstrate a reduction in human allergenicity ( for purposes of which, shall mean proteins or peptides for use in cosmetic, cleaning and oth er non - therapeutic consumer products )