definiens: shall mean an instrument, whether in, single or multiple modules, that includes a Thermal Cycler or Temperature Cycling Instrument as defined below and a detector which can be used to detect a fluorescence optical signal while the Thermal Cycler is in operation and without opening the vessel(s ) in.which amplification is occurring . For the purposes of this Agreement, Real - Time Thermal Cyclers are limited to the following products : [COMPANY] Smart Cycler, GeneXpert and any [COMPANY] Thermal Cycler containing one or more I - CORE modules ( as those modules are defined in Exhibit ! ), and are further limited to thermal cyclers with a capacity of no more than five hundred ( 500 ) reaction aliquots, vessels or tubes that can be thermally cycled at one time . For avoidance of doubt a Real - Time Thermal Cycler does not include disposable test cartridges or reaction tubes for containing reagents that are to be used with such Real - Time Thermal Cyclers