definiens: means the following amount of Net Sales of a Collaboration Product in the US Territory dW'ing each of the following calendar years : B-1 2007 2008 2009 2010 2011 2012 Calendar Year and future years u.s . Sales $ 32 million $ 61 million $ 95 million $ 125 million $ 155 million $ 200 million B-2 Study No EXHIBITC INITIAL DEVELOPMENT PLAN New River Pharmaceuticals Inc., Initial NRP104 Development Plan ( Pediatric ) ! Clinical, ftl:1iirmacOI .99Y.' . F.'harmacokinetic·Studies NRP104.101 NRP104.t02 NRP104.103 AP.l1armacoklnetic Study toast;~ .§§theJate of absorption, and Completed th~.pl"i3I .t)ioavaHabllityof two, d.os ~ l,~yelsNRP104 capsules to ~Q,$~()ft.he, .reference produ¢tS .• D ~ xedr.lneSpa.l1 ~ l, Jlesand AcfdEir ~ UXR Capsules In ' fastingi ~d,(jit y()iurtt ~ ets(n::i2Q ) FQ9ii ~ ff ~ ctstudy : COrf!pt~~~ A : Sihgle:,l:)ose •• ' 3 - tl'eatmerit,3 ~ p ~ floa /Cros, ~pver Ph ~ r ~ l'Ylacc)klnetlc StudytoASse .~~ Relatiye : Bioavailablllty ( ) f NRF » : 1047 ~ mg CapstJl ~ s ' ( 1 x70riig } J.JnClerFed ' ~tate and $ ( ) ILitiorivs;Fasted state in ' Healtt'1yA ~ ij ' it .Vol.unteers [ ) ( ) SeRtoportionalltystudy : GQm.pl¢lt~ Singl,~d()t;e ; ' ; Hre ~ tment .,.3 ~ penod, : lirc;)~over, pharm.aq(jklnetic ~M ~ Y · ' t9aS$ess · dQse, prOp'orti9haJitY .. 9tNRI?1()4,3bmg cap, s!J!es { 1x3.omgfv$ ' ~Om9 · ~~[$UI~~ .(1,)(~ .9fflglv~ · ;, ; t:9 ~ mg;p ~ ps!Jle$ ( ~.*tQ.oogl iln;iM ~ llhY ~ Ji!Jlt ~ gJYnl~~t ~OO ~ g j Multr ' l ~ o'se ' /~~arm ' ~l~·u~ tO · ~ ' t.c .~,j;:O ! ~g/. ' ... : : JB.!-l',,r . .... _ ~~y .. " " ., 9 9Pi1ipJ~ _ ~ ~BR1~~ ~*~7.t.d@~ ~,:·~~, aJtY9[M, 6r.~ii~ ~ (, ~J C - I EStimated Completion DI : lte Study ReportFirianz ~ d patab < l~~ ' loc~ : ; ~M ' he, ~cfllne ~<lta ~hticipate~ .PJlq ~ Qg Draft CSRanticipated',o410s/05 FIi1alCSR ' Clnticiip, ~ted, 05/~()/05 Study Reportjslj ~ ihg Fillalized Draft CSR8otic ; .ipijtoo ' 02128/05 i = inal¢SR ~ d ~ i ~ ip ~ t ~ d J>4!}1lQl ; NRP104.301 . .. -A Phase ' 3, Randomized, Multi - Center J. Double - Blind, . Parallel ' ; Group . · Placebo - Contr()n ~ St@¥QfNB.P1·P4i.~·t;hjJi : lr ~ oAged 6 - 12 Years with AHentiQri Deflcip : iyPe.ractivitydy;pfNRPt04 3,0 mg, SO m9,or 70m9Pt!f.[)~Y1 ? years with AttentioIJ.··Oefi¢itHyparktctlVliyQl8ortl&t·{APHD ) C-2 Cbmp ~ eted 1i'i.th~¢Jinlc In - Progress ltin snticlpate;d Cotnpi ~ tion date 05/0$/05 Anticipated completion date1Q 2005 tPLV 12121/04 Anticipated Completion date2Q 2005