definiens: means an Antisense Compound that:(a)(i ) is selected by the Joint Research Committee for research, optimization orpreclinical evaluation in the conduct of the Collaboration, ( ii ) is Controlledby a party, ( iii ) either is in a party 's or any of its Affiliates ' possession asof the Effective Date or is discovered or acquired by either or both parties orany of their respective Affiliates during the Collaboration Term but outside theconduct of the Collaboration, and ( iv ) binds to or otherwise modulates a ProgramTarget ; ( b ) is first [ * * ] in the conduct of the Collaboration ; or ( c ) isotherwise designated a Program Antisense Compound by the Joint ManagementCommittee ; provided, however, that in no event shall [ * * ] become a ProgramAntisense Compound unless such designation is affirmatively agreed to by theJoint Management Committee after disclosure of the nature of such Pre - existingObligation by the applicable party