definiens: means an internal research effort on the developme nt of ASO Compounds directed to a Target for use as ASO Products conduc ted by Isis conducted outside the course of the Col laboration whereby such internal research effort on such Targe t has advanced to a stage that is equivalent to the achievement of the Critical Success Factors for a V alidation Target as reasonably evidenced to [COMPANY] b y written documentation of Isis ; provided, however, that if there is a disagreement as to whether such Target has advanced to a stage that is equivalent to the achievement of the Critical Success Factors for a Validation Targ et such matter shall be referred to the Executive Committee for resolution, and lacking resolution by the Exec utive Committee such internal research effort shall be de emed an Isis Internal Program . The existing Isis In ternal Programs in the Collaboration Therapeutic Areas as of the date of this Agreement are listed in Schedule A