definiens: means that th e level of efforts to be expended by a Party under this Agreement with respect to the research, discov ery, Development, Manufacture and/or Commercializat ion of Licensed Compounds and Licensed Products will be co nsistent with the level of reasonable, diligent, go od faith efforts and resources that would normally be used b y such Party ( whether acting alone or through its A ffiliates ) for a pharmaceutical product of similar commercial potential at a similar stage in its lifecycle, and taking into account issues of safety and efficacy, product prof ile, market and profit potential, the patent and ot her proprietary position of the product, the then curre nt competitive environment for such product, the li kely timing of such product ’s entry into the market, the regula tory environment, and other relevant scientific, te chnical and commercial factors . Commercially Reasonable Efforts shall be determined on a market - by - market and indication - by - indication basis for a particular Lic ensed Product, and it is acknowledged and understoo d that the level of efforts will be different for different ma rkets and will change over time