definiens: shall mean the carrying out of obligations or tasks by a Party in a sustainedmanner using good faith commercially reasonable and diligent efforts, which efforts shall be consistent with the exerciseof prudent scientific and business judgment in accordance with the efforts such Party devotes to products or researchor development projects owned by it of similar scientific and commercial potential . Commercially Reasonable Effortsshall be determined on a Target - by - Target and Antibody - by - Antibody ( including MTCs ) basis in view of conditionsprevailing at the time, and evaluated taking into account all relevant factors ; including, but not limited to the possibilitythat significant increases in the CPI over the Term will lead to an increase in the cost of external services and areduction in the number of FTEs funded under the Discovery Program ; which, in turn, may adversely affect thelikelihood of Regeneron achieving the Collaboration Objectives