definiens: means all Know - How Controlled by Jounce or its Af filiates as of the Effective Date or at any time during the Term that is ( a ) rea sonably necessary or useful for the research, Devel opment, Manufacture and/or Commercialization of any Collabo ration Candidate, Product, or related Diagnostic Pr oduct or to use the Program Biological and Chemical Mater ials, or ( b ) incorporated or otherwise used in ( inc luding in the Manufacture of ) any Collaboration Candidate, Pr oduct, or related Diagnostic Product ; but excluding any Know - How solely related to any Lapsed Program, Laps ed Targets or Excluded Jounce Targets, including an y Know - How solely related to any Biologic that binds to any Lapsed Target or Excluded Jounce Target ( exc ept as and to the extent applicable to any then - existing P rogram under this Collaboration from time to time )