definiens: means the gross amounts invoiced by Cornerstone, any of its A ffiliates or any of its sublicensees for sales of Product in the Territory to third parties, less the total of the following deductions to the extent actually and reasonably allowed or incurred in connection with such sales : ( a ) reasonable and custom ary trade, cash and quantity discounts off the invoiced price ; ( b ) excise, sales and other consumption taxes and custom duties to the extent included in the invoice price ; ( c ) freight, insurance and other transportation charges to the extent in cluded in the invoice price ; ( d ) amounts repaid, credited or accrued, or allowances or adjustments made, by reason of returns, rejections, or recalls, or because of chargebacks, retroactive price reductions, or billing errors ; ( e ) reasonable and customary rebates and chargebacks to pharmacy benefit managers, federal, state, or local governments ( or their agencies or purchasers ), and managed health organizations ( including without limitation Medicaid rebates ) ; and ( f ) any amounts actually written off or specifically identified as uncollectible in accordance with GAAP ; solely to the extent the above deductions are taken in accordance with GAAP applicable to the particular selling entity