definiens: shall mean ( i ) Know -How Enumeral owns or controls with respect to the First Antibody as of the Effective Date, ( ii ) Know -How Enumeral owns or co ntrols with respect to the Subsequent Antibody as of the Option Exercise Date ( as defined in Section 4.7 ) and ( iii ) the, Patent Rights Enumeral owns or controls claiming the First Antibody and, upon the Option Exercise Date, the Subsequent Antibody ( includ ing, without limitation, any patents issuing on such patent applications, and any substitution, extension or supplementary protection certificate, reissue, reexamination, renewal, division, continuation or continuation -in - part with respect thereto during t he Term ) ; and in the case of each clause ( i ), ( ii ) and ( iii ) only as such Know How and Patent Rights relate to the First Antibody and/or Subsequent Antibody, methods of using, administrating, manufacturing or formulating said First or Subsequent Antibody, useful or necessary for Pieris to develop and commercialize Products under this Agreement . The Patent Rights as of the Effective Date are listed in Exhibit A