definiens: means any composition of matter ( including small molecules, other compounds, peptides and proteins)where ( as described below ) of such composition is through binding ( whether non - covalently ( including ionically, electrostatically, through hydrophobic interactions or through hydrogen bonds ) orcovalently ) to one or more of : VEGF - A, VEGF - B, VEGF - C, VEGF - D, VEGF Receptor-1, VEGF Receptor-2 and VEGFReceptor-3 . If a given composition has multiple mechanisms of action by binding to or inhibiting multiple kinases, thensuch composition shall be deemed to have by binding to one or more VEGFs andVEGF Receptors ( as specified above ) if, and only if, such composition binds at least as specifically to VEGF(s ) orVEGF Receptor(s ) as to the other kinase(s ) by which such composition exerts its other mechanism(s ) of action;otherwise, such composition shall not be a VEGF Receptor Inhibitor