definiens: means the oligonucleotide known as ISIS 678354 ( also known as IONIS - APOCIII - L ) havingRxRxP = OMeP = OMeP = OMeP = OMeP = OMeMeMeP = OP = OMeMeMeMeP = ORxRxMeMeMeMeMeMeMeMeMeMeMethe following sequence and chemistry : 5'-THA - AHAGCUUCTTGTCCAGCUUUAU-3 ' . Theunderlined residues are 2'-O-(2 - methoxyethyl ) nucleosides ( 2'-MOE nucleosides ) . The residues are arranged so thatthere are five 2'-MOE nucleosides at the 5 ' and 3 ' ends of the oligonucleotide flanking a gap of ten 2'-deoxynucleosides . The cytosine and uracil bases are methylated at the 5 - position