definiens: , or means the materials listed in Schedule D ; means the value of the Active Materials, as set f orth in Schedule D ; or means the aggregate actual volume of Product orde red by Client during the 100 % binding Calendar Quarter(s ) or three month period covered by the relevant Forecast ; has the meaning specified in Section 4.2.3 ; shall mean any untoward medical occurrence in a p atient or clinical trial subject administered a human medicinal product irrespective of whether there is a causal relationship with the treatment or not . An Adverse Event can therefore be any unfavorable and unintended sign ( e.g. abnormal laboratory finding ), symptom, or disease temporally associated with the use of the medicinal product i n humans, whether or not considered related to the Pr oduct ; - 1 - [ * * ] = Portions of this exhibit have been omitted p ursuant to a confidential treatment request