definiens: shall mean any and all patents and patent applications in the Territory ( which for the purposes of this Agreement shall be deemed to include certificates of i nvention and applications for certificates of invention ) which during the term of this Agreement are owned by ISIS or to which ISIS through licen se or otherwise acquires rights which ( a ) claim, cover or relate to C ompound and/or Product including without limitation those patents a nd patent applications which ( i ) are Compound patents and patent applicat ions listed on Schedule 1.16 ( a ) ( i ) ; or ( ii ) are ISIS Core Technology pa tents and patent applications listed on Schedule 1.16 ( a ) ( ii ) ( to the ext ent that such ISIS Core Technology patents and patent applications a re necessary or useful to [COMPANY] in the Field ) and patents and patent a pplications which claim, cover or relate to Core Technology Improveme nts ( to the extent that such Core Technology Improvement patents and pate nt applications are necessary to [COMPANY] to practice effectively in the Fiel d ) ; or iii ) are ISIS Manufacturing Technology patents and patent applications listed on Schedule 1.16 ( a ) ( iii ) ( to the extent that such ISIS Manufacturing Technology patents and patent applications a re necessary or useful to [COMPANY] in the Field ) and patents and patent a pplications which claim, cover or relate to Manufacturing Technology Improvements, to the extent that such Manufacturing Technology Improveme nt patents and patent applications are necessary or useful to Merc k in the Field ; or ( b ) are divisions, continuations, continuations - in - p art, reissues, renewals, extensions, supplementary protection certifi cates, and the like of any of the foregoing patents and patent application s and foreign equivalents thereof