definiens: means, wi th respect to the efforts to be expended, or consid erations to be undertaken, by a Party or its Affiliate with respect to any objective, activity or decision to b e undertaken hereunder, reasonable, good faith efforts to accomp lish such objective, activity or decision as a similarly situated pharma ceutical company would normally use to accomplish a similar objective, activity or decision under similar circu mstances, it being understood and agreed that with respect to the Development, Manufacture, seeking and obtaining Regulatory Approval, or Commercialization of the Compound or a Product, Licensee may take into accou nt : ( a ) issues of efficacy, safety, and expected an d actual approved labeling, ( b ) the expected and actual comp etitiveness of alternative products sold by Third P arties in the marketplace, ( c ) the expected and actual produc t profile of the Compound or Product, ( d ) the expec ted and actual patent and other proprietary position of the Product, ( e ) the likelihood of Regulatory Approval and/or pricing approval given the regulatory structure inv olved, including regulatory or data exclusivity, ( f ) the expected and actual profitability and return on inv estment of the Compound or Product, taking into con sideration amounts owed hereunder, and ( g ) all other relevant scientific, technical, regulatory and commercial fa ctors