definiens: shall mean any formulation ( as determined from time to time in accordance with this Agreement ) containing as an active constituent ~ humanized immunoglobulin having complementarity determining regions, as disclosed in U.S Patent No . 5,840.299 ( or any functionally equivalent modification thereon, and heavy and light chain variable frameworks from predominantly human acceptor immunoglobulin : Oi ) an antigen - binding fragment of such humanized immunoglobulin having at least ten ( 0 ) amino acids : or ( iii ) any such immunoglobulin or fragment as described in ( i ) and ( iil or any other fragment comprising the complementarity determining region of such humanized immunoglobulin, fused to another polypeptide fragment or another monomeric or polymeric compound, in each case under clauses ( it ( m, and ( iii ) which specifically binds to an Alpha-4 Integrin and which has a molecular weight greater than 2,000 Daltons . The term Licensed Product shall, as applicable, include Antegren . A Licensed Product approved for several different indications shall be considered a single Licensed Product