definiens: means the percentage based on the applicable level of Orladeyo Direct Sales in a calendar year as setforth in the chart below : Payment Tiers based on Annual Orladeyo Direct SalesOrladeyo Direct Sales Royalty RateA. Annual Orladeyo Direct Sales of up to $ 350,000,0008.75%B. Annual Orladeyo Direct Sales exceeding $ 350,000,000 and less than orequal to $ 550,000,0002.75%C. Annual Orladeyo Direct Sales in excess of $ 550,000,0000 % means all License Revenue received by the Seller or any of the Seller ’s Affiliates from any Licensee ofOrladeyo, other than ( a ) the regulatory approval milestone payable under Section 8.2.1 of the Torii License, ( b ) in respect of Orladeyo Direct Sales, and ( c ) Product Partnering Revenue attributable to Orladeyo