definiens: means, with respect to particular obligations or tasks, such level of effortsapplied to carry out such obligations or tasks consistent with the efforts used in the biopharmaceutical industry by acompany of comparable size in connection with the development or commercialization of biopharmaceutical productsthat are of similar status, to accomplish such obligations or tasks, at the same stage of development orcommercialization, as applicable, for internally developed healthcare products in a similar area with similar marketpotential, at a similar stage of their product life taking into account the existence of third party ( not Licensee ’s own)competitive products in the market place or under development, the proprietary position of the product, the regulatorystructure involved, the anticipated profitability of the product and other commercially - relevant factors . It is understoodthat such factors may change from time to time based upon changing scientific, business and marketing and return oninvestment considerations and that the level of efforts typically devoted by Licensee may also change, based on suchchanges and/or changes in development or commercial stage