definiens: means ( i ) the license and co - development agreement datedSeptember 15, 2006, between Cell Therapeutics, Inc., Cell Therapeutics Europe S.r.l, andNovartis International Pharmaceutical Ltd. ( ) and ( ii ) the termination agreement datedJanuary 3, 2014 between Cell Therapeutics, Inc. and Novartis . means all direct project expenses incurred in respect of ThirdParties after the Restatement Date, which are specifically identifiable and incurred for services ormaterials provided by them directly in their performance of the Development in accordance withthe Development Plan and Development Budget, or Medical Affairs Activities andCommercialization expenses incurred in the performance of the Commercialization TransitionPlan, as appropriate ; such expenses to have been recorded as income statement items inaccordance with Accounting Standards and for the avoidance of doubt, not including pre - paidamounts ( until expensed in accordance with applicable Accounting Standards ) or recoverabletaxes