definiens: means a Phase IIa trial aimed at treating cognitive impairment associated with schizophrenia, which Phase IIa trial ( a ) tests multiple doses of Compound 3454, ( b ) is placebo - controlled and double ~ blinded, ( c ) requires dosing per patient based on a treatment plan with a period of at a minimum of [ 8 ] weeks in duration, ( d ) includes a minimum of [ 160 ] patients randomized [ ( 3 dose groups and 1 placebo group with 40 patients initially CONFIDENTIAL TREATMENT IS REQUESTED FOR INFORMATION IN BOLD AND BRACKETS enrolled per group ) to be studied so that at least 160 patients receive at least one efficacy assessment post baseline ], ( e ) has as its primary outcome an assessment of cognition [ based upon MATRICS ], ( f ) uses secondary outcome measures in two areas : general psychopathology ( positive and negative symptoms of schizophrenia ; depression ) and social competence, and ( g ) includes smokers and non - smokers