definiens: means any gene target that is a or under the Neurology II Agreement and any other gene target th at ( a ) as of the Execution Date, ( i ) is not encumbe red by [COMPANY] under an agreement with a Third Party such that Ion is could not grant [COMPANY] the license under Section 4.1.1 of this Agreement with respect to such gene target, an d ( ii ) has not yet achieved Target Sanction status, and ( b ) as of the Execution Date, the Effective Date or during th e Research Term, the expression or activity of the gene in neurons is demonstrated to have an association to a ny one or more of the following ( each of ( A ) throug h ( I ) below, a ): ( A ) [ * * * ] ; ( B ) [ * * * ] ; ( C ) [ * * * ] ; ( D ) [ * * * ] ; ( E ) [ * * * ] ; ( F ) [ * * * ] ; ( G ) [ * * * ] ; ( H ) [ * * * ] ; and ( I ) [ * * * ]