definiens: means, with respect to a Party ’s efforts with respect to anyobjective, those reasonable, good faith efforts and that level of resources required to accomplish such objectiveconsistent with the general practices such Party would normally use to accomplish a similar objective under similarcircumstances . With respect to any efforts relating to the Development, Regulatory Approval, Manufacturing orCommercialization, as applicable, of the Compound or Product by a Party, generally or with respect to any particularcountry, such Party will be deemed to have exercised Commercially Reasonable Efforts if such Party, subject to thisSection 1.14, has exercised those efforts normally used by such Party, in the relevant country, with respect to acompound, product or product candidate, as applicable ( 1 ) to which such Party or its Affiliates have similar rights,(2 ) which is of similar market potential in such country, and ( 3 ) which is at a similar stage in its development orproduct life cycle, as the Product, in each case, taking into account, at the time such efforts are to be expended, issues of safety, efficacy or stability ; product profile ; stage of development or life cycle status ; the competitiveenvironment ; market potential ; the patent and other proprietary position of the compound or product ; the potentialprofitability of the compound or product ; the cost - effectiveness of efforts or resources while optimizing profitability ; thefinancial resources available ; and other relevant scientific, technical, operational and commercial factors