definiens: shall mean the actual consideration paid to Company, its Affiliates orSublicensees by a Third Party customer for sales of Product, minus [ * ] . In the event a Product is co - packaged, co - formulated or otherwise sold in a manner that includes one or more active therapeutic ingredients in addition to aProduct ( such Product, a ), then Net Sales, for purposes of determining royalty payments onsuch Combination Product, will be calculated by multiplying the Net Sales of the Combination Product by the fractionA over A+B, in which A is the net selling price of the Product portion of the Combination Product when such Productis sold separately during the applicable accounting period in which the sales of the Combination Product were made, and B is the aggregate net selling price of the other active therapeutic ingredient of the Combination Product whensuch other active therapeutic ingredient are sold separately during the accounting period in question . All net sellingprices of the Product portion of the Combination Product and of the other active therapeutic ingredient of suchCombination Product will be calculated as the average net selling price of the said ingredients during the applicableaccounting period for which the Net Sales are being calculated in the particular country where the CombinationProduct is sold . In the event that, in any country or countries, no separate sale of either such above designatedProducts or such above designated other active therapeutic ingredient of the Combination Product are made duringthe accounting period in which the sale was made or if the net retail selling price for an active therapeutic ingredientcannot be determined for an accounting period, Net Sales allocable to the Product in each such country will bedetermined by mutual agreement reached in good faith by Columbia and Company prior to the end of the accountingperiod in question based on an equitable method of determining same that takes into account, on a country by countrybasis, variations in potency, the relative contribution of the Product and each other active therapeutic ingredient in thecombination, and relative value to the end user of the Product and each such other active therapeutic ingredient