definiens: means any Know - How, invention or discovery ( and all Intellectual Property claiming or covering such invention or dis covery ) conceived, discovered, or made by or on beh alf of Naia, its Affiliates, or its or their agents, Subli censees, or contractors ( other than [COMPANY] ), alone or jointly with any Third Party, in the course of the Research Prog ram or otherwise in connection with this Agreement, whether patentable or not, that ( i ) are directly related to GLP-2 receptor agonists and/or analogs of GLP-2 di scovered or invented by or on behalf of Naia, any Affiliate the reof, or any Sublicensee, alone or jointly with any Third Party, and any Intellectual Property claiming or Covering such invention or discovery, ( ii ) are methods or us es for the treatment of indications or treatment regimens for Licensed Products or XTEN Sequences, or ( iii ) compr ise, or are related to, other active pharmaceutical ingredients or therapeutic moieties . For the avoidance 6 of doubt, ( a ) excludes ( I ) any and all XTEN Sequences and derivative, modified, or truncated amino acid sequence compositions of XTEN Sequences conceived, discovered, or made in connect ion with this Agreement, or as a result of using [COMPANY] ’s Confidential Information, by either Party ( or an y Affiliate thereof ), solely or jointly with the other Party ( o r any Affiliate thereof ), ( II ) any XTEN Modificatio ns conceived, discovered, or made that were enabled as a result o f the exercise of rights granted by [COMPANY] under th is Agreement, or as a result of using [COMPANY] ’s Confidential Infor mation, by either Party ( or any Affiliate thereof ), solely or jointly with the other Party ( or any Affiliate ther eof ), or ( III ) methods of making such amino acid se quence compositions in ( I ) or ( II ) conceived, discovered, or made in connection with this Agreement, or as a result of using [COMPANY] ’s Confidential Information, by either Party or any Affiliate thereof, whether or not incl uded in a composition of any modified or unmodified GLP-2 and ( b ) such XTEN Sequences and sequence variants ther eof described in ( a ) shall be considered either or, a s appropriate