definiens: means a Protein that : ( a ) ( i ) is selected by the Joint Research Committee for research, optimization or preclinical evaluation in the conduct of the Collaboration, ( ii ) is Controlled by a party, and ( iii ) is encoded by a Program Target or derived from ( e.g, by means of amino acid substitutions, additions, deletions, and C - and N - temlinal fusions ) a Protein encoded by a Program Target ; ( b ) is first idenlifieEi er eiseoYeretl lnJ in the conduct of the Collaboration ; ( c ) is encoded by a Program Target or derived from ( e.g., by means of amino acid substitutions, additions, deletions, and C­and N - temlinal fusions ) a Protein encoded by a Program Target and is first identified or discovered by Schering - Plough or its Affiliates after Schering - Plou gh 's selection for Development of a Collaboration Product for such Program Target and prior to the earlier of ( i ) the time that such Program Target has become a Released Target or Reverted Target and ( ii ) the expiration or earlier tennination of this Agreement with respect to such Collaboration Product pursuant to Article 15 hereof ; or ( d ) is otherwise designated a Program Protein by the Joim Management Committee