definiens: shall mean ( i ) all patent applica tions ( U.S. and other ), whether filed during the Program Term or after its completion, claiming any inventions or discoveries conceived and reduced to practice in the course of the Resear ch Program by Symyx or TDCC or jointly by Symyx and TDCC, or conceived by Symyx before the Research Program and reduced to practice in the Research Program, which claim an Ag reement Compound or a Product, or method or process for the manufacture of an Agreeme nt Compound or Product, or a composition - of - matter containing an Agreement Compo und or Product, or a method or process for the use of an Agreement Compound in or for the manufacture of a Product, in each case that are necessary or materially useful for th e manufacture, use or sale of Agreement Compounds or Products in the Field, ( ii ) all divisi ons, substitutions, continuations, continuation - in - part applications, patents of addit ion, and reissues, re - examinations and extensions of ( i ) above,, and ( iii ) patents, utili ty models or similar grants of rights issuing on any of the preceding of ( i ) or(ii ) above . For purpo ses of this definition, shall be construed to include an actual reduction t o practice or a constructive reduction to practice where the concept is defined in sufficient detail that it may have been reduced to practice by one skilled in the art without excessiv e efforts beyond those efforts that one skilled in the art would reasonably employ . It is understoo d and agreed that Program Patents shall not include any Combinatorial Chemistry Technology or r esults of Independent TDCC Research