definiens: means ( a ) [ US patent number 6,335,180 and all Patents sharing a claim of priority therewith I, ( b ) [ US patent number 6,482,611 and all Patents sharing a claim of priority therewith !, ( c ) [ US provisional patent application serial number 60/433,363 and all Patents claiming priority therefrom !, and ( d ) [ the subject matters of claims 186, 188, 189, 191, and 192 of PCT patent publication No . WO 02/08221 having WIPO serial No . PCTIUS01l22930, and all counterparts of ( a ) through ( d ) above in all countries ., From time to time during the course of this Agreement, the Parties may choose to mutually agree ( with each Party exercising its sole discretion in such matters ) to amend this definition of VR 1 Related Patent Rights to include additional Patents or patent claims including those which assert an earliest priority date no later than twelve ( 12 ) months after the expiration of the Program Term and are limited to research tools used in and specific to VRI research or uses ofVRI Modulators generally ( i.e., research tools or uses that would be applicable to all VRI Modulator s rather than to particular structural classes of, groups of, or individual chemical compound s ) . Any such amendment shall be only by a written instrument duly - executed by both Parties