definiens: means any event, result, effect, occurrence, fact, circumstance, development, condition or change, or series of events, results, effects, occurrences, facts, circumstances, developments, conditions or changes, that, when considered either individually or in the aggregate is material and adverse tothe business, operations, assets, liabilities or condition ( financial or otherwise ) of the Purchased Business, taken as a whole ; except to the extent that the material adverse effect results from or is caused by ( i ) generalchanges in Canadian or global economic, political or regulatory conditions, including war, armed hostilities, acts of terrorism and natural disasters ( ii ) general changes in the markets or industry in which the PurchasedBusiness operates, ( iii ) a change in applicable Laws or the enforcement, implementation or interpretationthereof, except for judgements, awards or decrees that relate specifically to the Corporation, ( iv ) a change inaccounting rules, including U.S. GAAP, ( v ) the Purchased Business ’ failure to meet internal or publishedprojections, forecasts or revenue or earning predictions for any period, provided that the underlying causes of 11 such failures ( subject to the other provisions of this definition ) shall not be excluded, ( vi ) any state of facts, condition, change, event, occurrence or development relating to or resulting from the products or productcandidates of any Person ( other than the Corporation or its Affiliates ), including the entry into the market ofproducts ( including Generic Versions of the Products ) competitive with any of the Products, ( vii ) theannouncement of this Agreement and the U.S. Asset Purchase Agreement and the agreements andtransactions contemplated hereby or thereby or the CCAA Proceedings, or the Chapter 11 Cases, includingthe impact of such announcement or pendency on the relationship of the Corporation with any supplier, distributor, customer, partners or similar relationship or any loss of employees resulting therefrom, or ( viii ) anyact or omission of the Corporation prior to the Closing Date taken or not taken, as applicable, required by theterms of this Agreement with the prior consent of or at the request of the Purchaser ; except, in the case of ( i),(ii ), ( iii ) and ( iv ), to the extent that any such event, result, effect, occurrence, fact, circumstance, development, condition or change affects the Corporation or the Purchased Business disproportionatelycompared to other participants in the specialty pharmaceutical industry