definiens: means, with respect to the efforts to be expended by a Partywith respect to the objective that is the subject of such efforts, reasonable, good faith efforts and resources toaccomplish such objective that such Party would normally use to accomplish a similar objective under similarcircumstances, it being understood and agreed that with respect to the Commercialization of the Licensed Product inthe Field in the Territory by Chiesi, such efforts shall be similar to those efforts and resources consistent with theusual practice of Chiesi in pursuing the Commercialization of drug products owned by it or to which it otherwise hasrights that are of similar market potential as a Licensed Product in the Territory, taking into account all relevantfactors, including the orphan drug status ( if any ) of the Licensed Product and other regulatory matters, safety andefficacy matters, product labeling or anticipated labeling, pricing, present and future market potential, pastperformance of the Licensed Product, past performance of Chiesi ’s own drug products that are of similar marketpotential ( taking into account that the Licensed Product is intended for the treatment of a rare disease ), financialreturn [ * * * ], medical and clinical considerations, present and future regulatory environment and competitive marketconditions, all as measured by the facts and circumstances at the time such efforts are due . It is anticipated that thelevel of effort constituting Commercially Reasonable Efforts may change over time . With respect to theCommercialization of the Licensed Product in the Field in the Territory by Chiesi, such efforts shall include [ * * * ]