definiens: shall mean the gross invoiced sales price for all ICON Licensed Products sold by ( i ) ICON or ICON’sSublicensees or their respective Affiliates to Third Parties ( other than Distributors in the United States or any Major European Country ) anywhere in theworld, or ( ii ) ICON ’s or ICON ’s Sublicensees ’ or their respective Affiliates ’ Distributors in the United States or any Major European Country to ThirdParties in such countries ( each a ) less ( a ) allowances for normal and customary trade, quantity and cash discounts actually allowed and taken,(b ) transportation and shipping, freight, handling, insurance and postage charges, if prepaid by the Seller and included on Seller ’s bill or invoice as aseparate item, ( c ) credits, rebates, returns pursuant to agreements ( including, without limitation, managed care agreements ) or government regulations, to the extent actually allowed, ( d ) sales, use and other consumption taxes similarly incurred to the extent included in the invoice as a separate item andactually paid by Seller, ( e ) retroactive and temporary price reductions that are actually allowed or granted, ( f ) discounts ( including coupons andvouchers ) pursuant to indigent patient programs and patient discount programs, to the extent taken, or ( g ) rebates paid to wholesalers for inventorymanagement programs or distribution management agreements, in accordance with ICON ’s practice reasonably and consistently applied