definiens: . Licensed Product Biomarkers means any and all biomarkers ( includingmetabolite, DNA, RNA and protein profiles ) discovered or developed by or on behalf of API during the Term or discovered ordeveloped by or on behalf of AVEO prior to the Effective Date or during the Term that ( a ) are for use with ( including use inclinical testing of or use in any decision whether to prescribe ), or ( b ) relate to, are associated with or are correlated withpatient populations or tumors that do or do not respond to treatment with, in the case of each of ( a ) and ( b ), any one ( 1 ) ormore Licensed Product(s ) . For purposes of clarity, include biomarker tests for detecting andmeasuring levels of any of the biomarker molecules described in the preceding sentence, whether in the form of testingproducts, test kits or tests performed at a centralized testing laboratory . Any such biomarker or biomarker test is a LicensedProduct Biomarker regardless of its stage of discovery, development, advancement or commercialization, and whether or notthe biomarker or biomarker test is already validated or recognized by any Regulatory Authority . For purposes of thisdefinition, biomarkers or biomarker tests include those(y ) discovered or developed by API ’s or AVEO ’s respective Affiliates, Sublicensees or contractors, and ( z ) discovered ordeveloped by or on behalf of KHK under the KHK Agreement to the extent that such biomarker or biomarker test falls withinthe definition of in the KHK Agreement