definiens: shall mean work performed by FTEs at DPI toward thegeneration oflVirtual Librar$ideas and Ior development andrefinement of Protocols forsyntbesis and purification of Compounds of interest to [COMPANY], as directed by a Pfizerapproved Request for Services . Additionally, the following defmitions will be modified as set out below ; the term should read in its entirety as follows••• Certain confidential ponions of this Exhibit were om;1ted bymeans of blackout of the lexl ( ID : MMark " ) . This, EX, hibithas been tiled separately with the Secrtlary afme Commission without the Mark pursuant totheCompany 's ApplicatIOnRequesting Confidential Treatment under Rule 24b-2 under the 1934 ACL2***-I :x : l~--tc;-:)::::::=r - n ii2!2 ..., .,- --4=0 :x : lrnr - n-.•.t:= :) ~c:::::=00:<rTl r -- C'-:I - Ir - nc:::::ISection 2.2 the frrst sentence shall be deleted and replaced with : " Upon recei t of aRequest for Service, with the IS substructure search term ori ' atin with [COMPANY] DPTwill promptly conduct a search of its ynthesized structure database ' Section 2.4 shall be added . " From time to time, DPI will submit\ISIS substructures)\ search term representing a\Virtual Library)of Compounds to [COMPANY] during the weekly _ teleconference or electronically . This structurc submission indicates DPT 's willingness tperform Services . If [COMPANY] approves ofthe ~ S substructure search termjproposed, aRequest for Services will be generated . The eguest for Services will request eitherProtocol Services, ' nvoiced to fizer on an FT basis or Compound Services, invoiced tPfizer on a ost er om ound or ost per Tangible Library asis ( the ) . ARequest for Services shall be sent to ChemRx Advanced echnolo ' es,385 ster PointBlvd . Suite I, South San Francisco, California 94080, Attention harles Johnson ( pfizerProject Leader ) With regard to Section2, when [COMPANY] authorizes DPI toperform the Service a copy of the Request for Service shall be sent tolMS Kendra Berger ) * * * TControllClJ.Discovery Partners International, Inc., 9640 Towne Centre Drive, San Diego, CA 92121.";,4 The following changes shall be made to Section 3 and Section 4 relating to Payment andPayment for Production of Compound Libraries, Section 3.1.4, the last sentence shall be deleted and replaced as follows : " DPT 's invoicesshall be sent to : [COMPANY] Global Research and Developmentl,50 Pequot Avenue, NewLondon, Connecticut 06320, AttentioniMs . Kate Lawrenc~\The minimum and themaximum compounds comprise compounds from both Compound Service andCompound Resynthesis Service,"Section 4.1.1 shall be deleted in its entirety and the following shall be added : ' Theparties agree that the production and purification of Compounds with the criteria set forthin Schedule 4.1 affixed hereto shall be calculated on a\Cost per Compound on an\\illdividual LibIili}!basis, in accordance with the table below:***-I :x : l~-ICI- --4 c::li:::::lCJr - r;r - n_=:;:J.t:= :) ~c:::::=sI"Ic = I3]~_I_c_o_m_p_o_un_d_s_2_5_0_1 _ an_d_a_b_ov_e s_90_._00 1:-,.•