definiens: means each compound comprising an oligonucleotide -based immunoregulatory sequence ( ) thatinhibits ( [ * ] unless otherwise mutually agreed by the JSC withou t escalation pursuant to Section 3.1.4 ) in a [ * ] ( such [ * ] tobe mutually agreed by the Parties through the JSC ) for [ * ] or [ * ], as applicable for that Program, and all derivativ es andimprovements of such compound, ( a ) that are existin g as of the Effective Date or ( b ) that are Research ed and/or Developed byDynavax under a Dynavax Program or ( c ) as identifie d, further modified, optimized or otherwise Researc he d or Developed byGSK under a [COMPANY] Development Program . In particular, for the TLR 7/9 directed compounds, the oligonucle otide - based IRSmust have [ * ] unless otherwise mutually agreed by the JSC withou t escalation pursuant to [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THESECURITIES EXCHANGE ACT OF 1934, AS AMENDED