definiens: means orders placed prior to Approval by a Regulatory Authority and not in connection with commercial production in connection with commercial launch following any such Approval . After January 1, 2008, all Developmental Orders shall be minimum noncancellable orders for quantities of not less than [ twenty - five ( 25 ) ] grams each, such quantities currently forecasted by NOVACEA at [ twenty - five ( 25 ) ] grams for 2008, [ thirty ( 30 ) ] grams for 2009 and [ twenty - five ( 25 ) ] grams for 2010 . For Developmental Orders on an annual basis after 2010, NOVACEA shall notify PLANTEX of its minimum noncancellable quantities for the applicable year ( not to be less than [ twenty - five ( 25 ) ] grams each year ) no later than September 30 of the preceding calendar year