definiens: shall mean u sing, in each of the Major Countries, an equivalent degree of effort as GTX, its Affiliate or a GTX Unaffiliat ed Sublicensee would use to promote, market, distri bute and sell a product of it own that is of comparable mark et potential in the respective Major Countries duri ng the same time period ( as determined by consideration of, wit hout limitation, potential market, patent protectio n, and availability of competitive products ), including bu t not limited to, engaging in the following activit ies ( subject to any applicable U.S. FDA restrictions or other appli cable legal restrictions ): [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS D OCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANTIS PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED