definiens: means, he, reaunent or prevention of I generally ackoo .. ledged disease Of medic.al condition, a $ Ignifoean ' mlmfC$Wion of a di _ or medical oondilion, or symptoms associattd with . disease or mroicel oonditioo . for the avoidance of doubt, the trcalmcnt of diffetenl medical oondilions in pllicnu having the $ BffiC undcrlyingdi _ shall not be lreated as the _ Indkalion ( for example tilt : trea ~ nt of cardiac d, sease and tttinopathy in pllknu ... ith diabcles ), ... hile Iho . IIrea ~ nl of the satnC Wlldition in ~arilUlts of • single disease .dW1 be ueatul 115 the same IndiCII'ion ( for example : the treatment of ele""'led blood phenylalanine in dlSlicel PKU, moderate PKU,.nd hyperphenyLaLaninem il ( HPA ) Ire all one Indication )