definiens: means any biological molecule that is a member of the family of [ duaI­substrate phosphodiesterases ] generally known as PDE10, [ including, without limitation ], PDEIOA ( amino acid sequences of which are attached hereto as Schedule 1.48 ), and any and all of the following biological molecules related to PDElO : [ ( i ) naturally occurring biological molecules of human origin that are substantially similar in terms of amino acid sequence thereto and naturally occurring biological molecules of non - human origin derived from the comparable genomic locations in related strains of the applicable species in each instance including orthologs, paralogs, isoforms or polymorphisms ( including single nucleotide polymorphisms and insertion, deletion and splice variants ) ; and ( ii ) synthetic variants of such biological molecules including additions, substitutions, deletions ; and ( iii ) post­translational modifications ( including, but not limited to, glycosylation, sialylation, phosphorylation and ubiquitinylation ) of such biological molecule . ] 10 CONFIDENTIAL TREATMENT IS REQUESTED FOR INFORMATION IN BOLD AND BRACKETS 1.49 means any individual, corporation ( including any non - profit corporation ), general partnership, limited partnership, limited liability partnership, joint venture, estate, trust, company ( including any limited liability company or joint stock company ), firm or other enterprise, association, organization, entity or governmental entity