definiens: means the gross amount invoiced by [COMPANY] or its Affiliates or sublicensees for the sale of Product to Third Parties, commencing with the First Commercial Sale, less deductions for : ( i ) normal and customary trade, cash and quantity discounts actually given, credits, price adjustments or allowances for damaged Products, returns or rejections of Products ; ( ii ) chargeback payments and rebates ( or the equivalent thereof ) granted to group purchasing organizations, managed h ealth care organizations or to federal, state / provincial, local and other governments, including their agencies, or to trade customers ; ( iii ) freight, shipping insurance and other transportati on expenses directly related to the sale ( if actually borne by [COMPANY], it Affiliates or sublicens ees without reimbursement from any Third Party ) ; ( iv ) required distribution commissions / f ees payable to any Third Party pr oviding distribution services to [COMPANY] ; ( v ) sales, value - added and excise taxes, ta riffs and duties, and other taxes and government charges directly related to the sale, to the exte nt such items are included in the gross invoice price and actually borne by [COMPANY], its Affiliates or sublicensees without reimbursement from any Third Party ( but not in cluding taxes assessed agai nst the income derived from such sale ) ; and ( vi ) provisions for actual uncollectible amoun ts determined in accordance with Accounting Standards for Product sold by [COMPANY]