definiens: means ( i ) irofulven or 6 - hydroxyme thylacylfulvene ( also known as HMAF or MGI-114 or IUPAC name, ( 6 ’ R)-6’-hydroxy-3’-(hydroxymethyl)-2’,4’,6’-trimethyls piro[cyclopropane-1,5’-inden]-7’(6 ’ H)-one or ( 5‘R)-5’-hydroxy-1’-(hydroxymethyl)-2’,5’,7 ’ -trimethylspiro[cyclopropane-1,6’-indene]-4’-one ) ( CAS No . 158440 - 71 - 2 and/or CAS 187277 - 46 - 9 ) ( FDA UNII 6 B799IH05A http://fdasis.nlm.nih.gov/srs/ProxyServlet?mergeDat a = true&objectHandle = DBMaint&APPLICATION_NAME = fdasrs&actionHandle = default&nextPage = jsp / srs / Resul tScreen.jsp&TXTSUPE RLISTID=6B799IH05A ), an alkylating DNA damage repair inhibitor, having mole cular formula C 15 H18 O3, and/or ( ii ) any salt, free acid, free base, clathrate, solvate, hydrate, hemihydrate, anh ydride, chelate, conformer, congener, crystal form, crystal habit, polymorph, amorphous solid, homolog, isomer, stereo isomer, enantiomer, racemate, prodrug, isotopic or radiolabeled equivalent, complex or mixture of any of the foregoing with respect to IROFULVEN that has the same mechanism of action as IROFULVEN . For clarity, IROFULVEN includes the active pharmaceutical ingredient known as irofulven, together with any sa lt, free acid, free base, clathrate, solvate, hydra te, hemihydrate, anhydride, chelate, conformer, congener, crystal fo rm, crystal habit, polymorph, amorphous solid, homo log, isomer, stereoisomer, enantiomer, racemate, prodrug, isotopic or radiolabeled equivalent, complex or m ixture thereof . For the purposes of the AGREEMENT and this LANTERN AFC ADDENDUM, IROFULVEN does not include IROFULVEN analogs, illudin bound directly o r via a linker to a Conjugate or acylfulvene bound directly or via a linker to a Conjugate, including an illudi n analog bound directly or via a linker to a Conjug ate, acylfulvene analog bound directly or via a linker to a Conjugat e, IROFULVEN bound directly or via a linker to a Co njugate or Irofulven analog bound directly or via a linker to a Conjugate