definiens: means any Patent that ( a ) is Controlled by Five Primeas of the Effective Date or during the Term ( including Five Prime ’s interest in any Collaboration Patent jointlyowned with [COMPANY] ) and ( b ) is necessary or reasonably useful for the development of a Five Prime Pipeline Assetin combination with a Licensed Antibody or a Licensed Product ( other than any Active Ingredients that are notLicensed Antibodies ) pursuant to the Development Plan, but excluding ( i ) all Five Prime Licensed Patents, ( ii ) allPatents within the Five Prime Platform Technology, ( iii ) all Unilateral Patents, except to the extent that [COMPANY] hasreimbursed Five Prime for the Development Expenses for such Five Prime Unilateral Studies pursuant to Section4.4, and ( iv ) all Patents that come into Five Prime ’s Control as a result of a Change of Control of Five Prime