definiens: means, with respect to a particular GDNF Product and those activitieshereunder with respect to such GDNF Product including development and commercialization, those efforts and resources thatAMT would normally use with respect to a pharmaceutical product, which product is owned by AMT or to which AMT hassimilar rights with a similar market potential at a similar stage in development or product life as the GDNF Product, takinginto account all relevant factors, based on the facts and circumstances at the time, including without limitation safety andefficacy issues, other medical and clinical considerations, product labeling or anticipated labeling, product profile, presentand future market potential, past performance of similar products ( including both GDNF Products and AMT ’s ownpharmaceutical products that are of similar market potential ), competitive market conditions, the likely timing of theproduct ’s entry into the market, financial considerations, intellectual property considerations and the likelihood of regulatoryapproval