definiens: means, with respect to particular obligations und er this Agreement, those efforts and resources ( including e xpenditures ) required to carry out such particular obligation consistent with the usual practices followed by suc h Party in the exercise of its reasonable business discretion relating to other similarly situated pharmaceutical products at a similar stage of research, developme nt or commercialization which are of similar market poten tial at a similar stage in their development or pro duct life, taking into account issues of patent coverage, regu latory exclusivity, regulatory structure involved i ncluding anticipated or approved labeling and anticipated or approved post - approval requirements, safety and ef ficacy, product profile, the competitiveness of products in development and in the marketplace, supply chain management considerations, the proprietary position of the compound or product, the regulatory structu re involved, present and future market and commercial potential including competitive market conditions a nd probability of the profitability of the applicable products ( including pricing and reimbursement statu s achieved ), and other relevant factors, including technical, le gal, scientific and/or medical factors