definiens: means the Compound known as ISIS 416858 having the following sequence and chemistry:5′-AMeCGGMeCATTGGTGMeCAMeCAGMeUMeUMeU- 3′. The underlined residues are 2'-O-(2 - methoxyethyl ) ribose ( 2'-MOE nucleosides ) . The residues are arranged so that there are five 2'-MOE nucleosides at the 5 ' and 3'-ends of themolecule flanking a gap of ten 2'-deoxynucleosides . All of the cytosine bases are methylated at the 5 - position ( 5 - methylcytosine ) . Each of the 19 internucleoside linkages is a 3'-O to 5'-O phosphorothioate diester . It should be notedthat 2'-(2 - methoxyethyl)-5 - methyluridine ( 2'-MOE MeU ) nucleosides are sometimes referred to as 2'-(2 - methoxyethyl)ribothymidine ( 2'-MOE T ) . ISIS - FXIRx does not include any product containing Conjugate Technology