definiens: means ( A ) with respect to the first * * * * * * * * period following the launch of the firstCo - Promoted Product in the U.S. Territory, the * * * * * * * * of the good faith quotes obtained jointly by [COMPANY] andTargacept not less than * * * * * * * * prior to such launch from * * * * * * * * reputable CSOs in the U.S. Territory for the price thatwould be charged by such CSOs for performing a PDE on the terms and conditions of the quote specified in the then - currentapplicable Plan, or, if obtaining such quotes is not reasonably practicable, such other method as may be agreed by the Parties, and ( B ) with respect to each successive * * * * * * * * period thereafter, ( 1 ) the PDE Cost for the immediately preceding * * * * * * * * period, multiplied by ( 2 ) the sum of * * * * * * * *, rounded to the nearest one Dollar ( US $ 1 )