definiens: shall mean ( a ) all Know - How that [COMPANY] and its Affiliates Controlsas of the Effective Date or during the Agreement Term to the extent used by [COMPANY] or itsAffiliates to perform activities under this Agreement ( including [COMPANY] Sole IP and Roche’sinterest in Joint IP ) ( but excluding Supplemental Studies unless BPM opts - in pursuant to Section7.2 ), and ( b ) with respect to Program 2 and Program 4, any Know - How that [COMPANY] or itsAffiliates uses in Exploiting any Licensed Products for Program 2 and Program 4 ( as applicable)(but excluding Supplemental Studies unless [COMPANY] opts - in pursuant to Section 7.2 ), and in eachcase ( a ) and ( b ) that is necessary or useful to perform activities under this Agreement