definiens: means the alpha-4 - heta-7 mtegrm receptor subtype . J 1.4 ' AI ha-4 - Beta-7 CompoundAlpha-4 - Beta-7 Know - How " means any information, know - how or materials : ( i ) owned or controlled by TBC and/or any of its Affiliates as of the Effective Date relating to Alpha-4 - Beta-7 ; ( ii ) discovered or developed by or on behalf of TBC andlor any of its Affiliates during the term of this Agreement ; or ( iii ) owned or controlled by TBC and/or any of its Affiliates relating to the research, development, manufacture, marketing, use or sale of Alpha-4 - Beta-7 Compounds, and in each case which are not in the public domain . Alpha-4 - Beta-7 Know - How shall include, without limitation, all applications, registrations, licenses, authorizations, approvals and cOlTespondence relating to Alpha-4 - Beta-7 Compound(s ) andlor any form of dosage of pharmaceutical compositions which contain as an active ingredient one or more Alpha-4 - Beta-7 Compounds, submitted by TBC to regulatory authorities as well as all biological, chemical, pharmaceutical, toxicological, pharmaceutical, physical and analytical, clinical, safety, manufacturing and quality control data and information related thereto ., 1.6 means all patents and patent applications ( including linventors ' certificates, reissues, reexaminations, extensions or other governmental actions which extend any of the subject matter of a patent, and any substitutions, confirmations, registrations or - 2 -::ODMA\PCDOCS\Docs\339538\ ! CONFIDENTIAL TREATMENT REQUESTED additions of or to any of the foregoing ) which are owned or controlled by TBC ( and/or any of its Affiliates ), or to which TBC ( and/or any of its Affiliates ) through license or otherwise acquires rights, including, but not limited to those patents which cover the discovery, development, manufacture, marketing, use or sale of Alpha-4 - Beta-7 Compounds including any compositions­of - matter, processes for or methods of use thereof . } 1.7 shall mean the respective periods of three ( 3 ) consecutive calendar months ending on March 31, June 30, September 30 and December 31, for so long as this Agreement is in effect