definiens: means all Patents ( also referred to herein as ) and Know - How ( also ref erred to herein as ) ( i ) created or acquired [ * * ], ( ii ) which relate to a Project Gene, Rejected Project Gene, Protein Candidate, [COMPANY] Advanced Research Protein Candidate, Lexicon Advanced Research Protein Candid ate, [COMPANY] Licensed Product or a Collaboration Product, and ( iii ) which either ( A ) are conceived or created during the conduct of, or in connection wit h, First Pass Phenotypic Analysis or Advanced Phenotypic Analysis of a Proje ct Gene, Pre - Clinical Development, Clinical Development, any activities c onducted under a Commercialization Plan, or [ * * ], or ( B ) relate to [ * * ] ; provided that Project Patents and Know - How shall not include ( A ) Lexicon Knock - Out Technology, ( B ) [COMPANY] Gene Patents and Know - How, ( C ) Lexicon Pr e - Existing Patents and Know - How, ( D ) Restricted Rights Project Patents and Know - How, ( E ) Lexicon Product Patents Page 12 < PAGE > and Know - How, ( F ) [COMPANY] Excluded IP, or ( G ) gen eral Patents that cover inventions that could be used for products other th an a Collaboration Product, including, without limitation, Patents covering man ufacturing or process ( including purification process ) inventions . Notwit hstanding the foregoing, any Know - How created or acquired by [COMPANY] after a P roject Gene has been designated as a Rejected Project Gene ( or Patents c laiming any such Know - How ) shall not be included in the definition of Project Patents and Know - How and shall not be subject to this Agreement . Notwithstan ding the foregoing, Project Patents and Know - How shall exclude Patents and Know -How specific to ( i ) [ * * ], ( ii ) [ * * ], and ( iii ) [ * * ]