definiens: shall mean a non - tethered intermediate compound of a tethered compound ( as that term is described in U.S. Patent number 6,335,155 Bl ), where such tethered compound ( i ) is either ( A ) a compound that binds to the purine binding site of a Kinase, or ( B ) a compound that binds to the adaptive region of a Kinase ; ( ii ) is actually made or used by either Party alone or by both Parties jointly during the Research Term in the course of activities directed to a Target that is then a Collaboration Target in the performance of the Research Program in accordance with the then - current Research Plan ; and ( iii ) exhibits structure activity relationships and specific binding to one or more Kinase . For clarity, as used in this Section 1.23 shall mean that portion of the tethered compound which does not contain the linking or tethering moiety