definiens: of each other for purposes of thisAgreement.1.5 or the means the antisenseoligonucleotide compound having the following sequence and chemistry : 5’-[THA GalNAc]-GsGoAoMeCoAoTsTsGsMeCsMeCsAsGsTsAsAsToMeCoGsMeCsA -3 ’ ( including, but not limitedto, Vupanorsen ), including any pharmaceutically acceptable salts thereof . is aconjugate group having three GalNAc sugars linked to the oligonucleotide through a tris - hexylamino - phosphodiester linker as shown in Schedule 1.5 . The nucleosides are representedas follows : represents adenosine, represents guanosine, represents thymidine or 5 - methyl uridine, and represents 5 - methyl cytidine . The underlined nucleosides are 2’-O-(2 - methoxyethyl ) nucleosides ( 2’-MOE nucleosides ) . The internucleoside linkages are eitherphosphodiester ( indicated by subscript ) or phosphorothioate ( indicated by subscript ) . Thestereochemistry of the phosphorothioate linkages is not controlled, resulting in a racemic mixtureof stereo - random phosphorothioate linkages . The structure of the anionic form of AKCEA - ANGPTL3 - LRx is shown in Schedule 1.5