Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Study of AK156 in Primary Osteoporosis Patients

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with primary osteoporosis

          -  Patients who have vertebral fractures at the time of screening

        Exclusion Criteria:

          -  Patients diagnosed with secondary osteoporosis

          -  Patients with a current uncontrolled medical disorder or other condition which makes
             the patient unsuitable for the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.
Subject must be at most 89 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Evaluation of a Mobile Cardiac Outpatient Telemetry System Versus Standard Loop Event Monitor

Eligibility criteria:
Inclusion Criteria:

          -  syncope, pre-syncope or palpitations less frequently than every 24 hours Pre-syncope
             without loss of consciousness defined as transient dizziness, leghtheadedness,
             unsteadiness or weak spells: syncopal events with or without warning: palpitations
             Subjects with non-diagnostic 24 hours of monitoring related to symptoms within 45 days
             of enrollment into study Subject able to understand, assent to , and willing to sign
             the Informed Consent Form.

        Exclusion Criteria:

          -  Class IV heart failure Post Myocardial infarction less than or equal to 3 months
             Unstable angina defined as chest pain at rest, new onset of angina, or a change in
             existing patterns of angina.

        Subjects who are candidatees for or have had recent (less than or equal to 3 monthr) heart
        valve surgery History of sustained ventricualr tachycardia or ventricular fibrillation
        documented EF 35% or less with complex ectopy defined as PVC's 10 or greater per hour.

        Subject is less than 18 years old at the time of signing informed consent. Any condition
        which may prohibit the completion of or compliance with the protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Allogenic Bone Marrow Derived Mesenchymal Stem Cell Therapy in Cases of Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Laboratory diagnosis of factor 8 deficiency

          -  Dependent on exogenous factor 8 therapy

        Exclusion Criteria:

          -  Liver disease

          -  History of allergy to factor therapy

          -  Abnormal spleen by sonography
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Study to Assess the Bioequivalence of Famotidine Chewable Tablets and Film-Coated Tablets (0208-144)

Eligibility criteria:
Inclusion Criteria:

          -  Female participant is not pregnant or lactating

          -  Female of childbearing potential must use reliable means of contraception during the
             course of the study

          -  Is in good health

          -  Is able to abstain from smoking during the 24-hour periods before and during each
             treatment day

        Exclusion Criteria:

          -  Has any major systemic disorders

          -  Has a history of ulcers, other Gastrointestinal (GI) disease, or GI surgery

          -  Has or has a history of any illness or condition that might interfere with optimal
             participation in the study

          -  Has a history of asthma or severe allergies to drugs or foods

          -  Currently uses prescribed or non-prescribed drugs on a regular basis

          -  Has a recent history of drug/alcohol abuse

          -  Consumes more than 6 cups of coffee per day

          -  Has unconventional or extreme dietary habits

          -  Has donated blood or has been in a clinical trial in which they received an
             investigational drug during the past 30 days

          -  Has a history of allergy or intolerance to antacids

          -  Is known to be pregnant or is not using reliable means of contraception
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: The Influence of Timing of Cabergoline Initiation on Prevention of OHSS

Eligibility criteria:
Inclusion Criteria:

          -  Female less than 35 years under going Intra cytoplasmic sperm injection cycle for
             infertility (tubal factor or un explained infertility).

          -  18 or more oocyte 11 mm in diameter and/or E2 is more than 4000 pg/ml at any day of
             the stimulation cycle before or at HCG trigger

        Exclusion Criteria:

          -  patient with one ovary

          -  patients already receiving cabergoline treatment

          -  Severe Male factor infertility.

          -  Thyroid dysfunction.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Sugammadex Hypersensitivity Study (Study P06042)

Eligibility criteria:
Inclusion Criteria:

          -  18-55 years of age

          -  Serum tryptase <=11.4 mcg/L and fasting triglyceride levels within normal limits

          -  Safety laboratory tests and vital signs must have been within normal limits

          -  Screening electrocardiogram must have been clinically acceptable and parameters within
             normal limits

          -  Body Mass Index between 19 and 32 kg/m^2

          -  Females must have agreed to use contraceptives

          -  Other certain administrative criteria as described in the protocol

        Exclusion Criteria:

          -  Females who were pregnant or intending to become pregnant

          -  Subjects who would not be able to participate optimally in the study, in the opinion
             of the investigator

          -  Certain surgical or medical conditions, recent infections, or mental instability

          -  Positive test for certain drugs or history of alcohol or drug abuse

          -  Positive test for hepatitis B, hepatitis C, or Human Immunodeficiency Virus (HIV)

          -  Blood donation in the past 60 days

          -  A history of unexplained reaction or hypersensitivity reaction during previous surgery
             and/or anesthesia

          -  History of anaphylaxis from any cause, suspected history of hypersensitivity to
             cyclodextrins, or multiple drug hypersensitivities

          -  Heavy smoker

          -  Received certain medications in the past

          -  History of allergy, hypersensitivity, or intolerance to epinephrine at greater risk of
             developing adverse reactions after epinephrine administration

          -  Other certain administrative criteria as described in the protocol
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Utilization of Negative Pressure Suction to Reduce Aspiration in Oropharyngeal Dysphagia

Eligibility criteria:
Inclusion Criteria:

          -  Patients with videofluoroscopic evidence of aspiration with Rosenbek Penetration
             Aspiration Scale (PAS) greater than 5 for all tested food consistencies

          -  Gastrostomy tube dependence

          -  Exhaustion of conventional treatment options (physical, medical, and surgical
             therapies)

        Exclusion Criteria:

          -  Complete PES stricture

          -  Inability to follow commands

          -  Current malignant disease

          -  No gastrostomy tube present

          -  Less than two years of cancer-free survival (if applicable)

          -  Vulnerable populations: adults unable to consent, pregnant women, and prisoners
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Lentiviral FVIII Gene Therapy

Eligibility criteria:
Inclusion Criteria:

          1. Able to provide informed consent and comply with requirements of the study.

          2. Males ≥2 years with confirmed diagnosis of hemophilia A (endogenous factor VIII ≤2
             IU/dL or ≤2% of normal).

          3. A minimum average of 4 bleeding events per year requiring episodic treatment of factor
             VIII infusions or prophylactic factor VIII infusions.

          4. No measurable factor VIII inhibitor as assessed by the central laboratory and have no
             prior history of inhibitors to factor VIII protein.

          5. Agree to use reliable barrier contraception until 3 consecutive samples are negative
             for vector sequences.

        Exclusion Criteria:

          1. Significant liver dysfunction as defined by abnormal alanine transaminase, bilirubin
             and alkaline phosphatase.

          2. History of inhibitor against factor VIII.

          3. Evidence of active hepatitis B or C and currently on antiviral therapy.

          4. Have serological evidence of HIV-1 or HIV-2 with CD4 counts ≤200/mm3 (subjects who are
             HIV+ and stable with CD4 count >200/mm3 and undetectable viral load are eligible to
             enroll).

          5. Any evidence of active infection or any immunosuppressive disorder.

          6. Participated in a gene transfer trial within the last 6 months or in a clinical trial
             with an investigational drug within the last 12 weeks.

          7. Unable or unwilling to comply with study assessments.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Proposed Research Protocol For Male Infertility

Eligibility criteria:
Inclusion Criteria:

          1. Couples with "pure" male factor infertility of six months or more, defined as not
             pregnant in spite of being desirous of pregnancy for at least six months with normal
             sexual activity and no birth control. Primary and Secondary infertility included.

          2. Abnormality of any one of the sperm parameters according to WHO or Kruger for
             concentration, motility or morphology.

          3. Women aged 18 to 30 with a BMI between 18 and 30

          4. Women who testify that they are healthy with regular menstrual cycles between 25-35
             days per cycle.

        Exclusion Criteria:

          1. Uterine fibroids or ovarian cysts or tumors or suspected hydrosalpinx on US on prior
             fertility workup. Paraovarian simple cysts, OK.

          2. Prior PID, abdominal or pelvic surgery or abnormal HSG if done.

          3. Known allergy to medications used in protocol

          4. Diagnosed or suspected genetic or psychiatric disease in either patient.

          5. Azoospermia

          6. Female partner with a history of infertility with another partner

          7. Elevated FSH (over 10 units/L) in female partner if done.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Contradiction