Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole

Eligibility criteria:
Inclusion Criteria:

          -  Male of female aged 20 years or more

          -  History of reflux esophagitis

          -  Ongoing (until date of Visit 1) treatment with rabeprazole 10 mg, given once daily,
             for at least 4 weeks.The subject must take rabeprazole at least 4 days a week in the
             past 7 days prior to Visit 1.

          -  Persisting symptoms of heartburn experienced at least 2 days during the past 7 days
             prior to Visit 1.

        Exclusion Criteria:

          -  Use of other PPIs and/or H2RA during rabeprazole treatment

          -  History or having other gastrointestinal diseases

          -  History of upper gastrointestinal surgery

          -  Initiation of medications that can affect digestive functions within 4 weeks before
             study treatment

          -  Inability to complete questionnaires
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Topical Bethanechol for Improvement of Esophageal Dysmotility

Eligibility criteria:
Inclusion Criteria:

          -  Any adult patient treated at the Medical College of Georgia, with severe IEM as
             defined using current criteria: esophageal contraction amplitude <30 mmHg either 5 or
             10 cm above the lower esophageal sphincter, in 50% or more of saline swallows.

        Exclusion Criteria:

          -  Patients with severe comorbidities (including uncontrolled hypertension, severe
             coronary artery disease, and uncontrolled diabetes) will be specifically excluded from
             the study.

          -  Additionally, the use of bethanechol (as well as all other muscarinic receptor
             agonists) is contraindicated in patients with asthma, coronary insufficiency, peptic
             ulcers, Parkinson's disease, seizure disorder, recent gastrointestinal surgery, and
             hyperthyroidism. As such any patient with these disorders will be specifically
             excluded from this study.

          -  Women of childbearing age will also be specifically excluded (Bethanechol is listed as
             a pregnancy class C drug).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Open-label Study to Determine the Maximum Tolerated Dose of DSG3-CAART in Mucosal-dominant PV Patients (mPV)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of mPV by prior or screening biopsy and prior positive anti- DSG3
             antibody ELISA

          -  mPV inadequately managed by at least one standard immunosuppressive therapies

          -  Active mPV at screening

          -  Anti-DSG3 antibody ELISA positive at screening

        Exclusion Criteria:

          -  Active cutaneous lesions associated with PV that indicates mucocutaneous rather than
             mucosal-dominant disease

          -  Rituximab in last 12 months unless PV symptoms have recently worsened or anti-DSG3
             antibody titers have recently increased

          -  Prednisone > 0.25mg/kg/day

          -  Other autoimmune disorder requiring immunosuppressive therapies

          -  Investigational treatment in last 6 months

          -  Absolute lymphocyte count < 1,000/µL at screening
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Prospective Biomarkers of Bone Metabolism in Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Males with a diagnosis of hemophilia A with a historic baseline FVIII level ≤ 2%.

          2. Age > 16 years old

          3. Currently using ADVATE as FVIII replacement therapy

        Exclusion Criteria:

          1. Subject or guardian is unwilling or unable to give written informed consent and/or
             assent

          2. Joint or muscle bleeding within 2 weeks of Study Day 1

          3. Presence of a current factor inhibitor (>0.6 BU/mL via Nijmegan-modified Bethesda
             assay)

          4. Known collagen vascular bone disease.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application

Eligibility criteria:
Inclusion Criteria:

          1. Subject is informed and has been given ample time and opportunity to think about
             his/her participation and has given his/her written informed consent

          2. Subject is ≥18 years of age

          3. Subject's health status: individual is considered to be healthy (hypertension and
             hypotension is permissible. Other stable diseases at the time of testing are also
             permissible)

          4. Subject is capable of undergoing controlled hypoxaemia to the levels called for the in
             the protocol with minimal medical risk (unless only participating in the blood
             pressure study).

        Exclusion Criteria:

          1. Subject cannot expose their face fully for a reading to be taken

          2. Subject is unable to give informed consent

          3. Subject is outside of the specified age range

          4. Subject has already taken part in the study (all 4 sub studies)

          5. Subject with significant irregular heart rhythm or any disease that might affect the
             results of the study

          6. Subject is not capable of undergoing controlled hypoxia and would be placed at undue
             medical risk if this occurred

          7. Subject has any contraindications identified that would deem them unsuitable to take
             part
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Low VW Activity in Adolescent HMB

Eligibility criteria:
Inclusion Criteria:

          -  Post-menarchal females less than 21 years of age

          -  HMB defined as PBAC score greater than 100

          -  VWF:Activity more than or equal to 30 and less than or equal to 50 IU/dL x 2

          -  VWF: Activity /VWF:Ag ratio greater than or equal to 0.6

          -  Normal VW multimers, if performed

        Exclusion Criteria:

          -  Post menarchal females age greater than or equal to 21 years

          -  VWF: Activity less than 30 or greater than 50 IU/dL consistently, type 2 or type 3 VWD

          -  Presence of other bleeding disorders (thrombocytopenia, platelet function defect,
             coagulation factor deficiency, fibrinogen defect or deficiency)
Female
No healthy subjects accepted to join the trial.

Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3a Part ii

Eligibility criteria:
Inclusion Criteria:

          -  Both ears-drums intact and effusion-free

        Exclusion Criteria:

          -  Chronic illness including asthma, lung, or heart disease

          -  Pregnant or plans on becoming pregnant during study period

          -  Prescription meds other than birth control

          -  Previous problems with inhaling nitrous oxide (e.g., during dental procedure)

          -  Claustrophobia in confined spaces

          -  Unable to remain relaxed and quiet for up to 2 hours
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Decision-making and Emotion Recognition in Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Patient:

               -  Age over 18 years

               -  Patient diagnosed as having essential tremor

               -  Written informed consent

               -  Patient covered by the French health insurance system

          -  Control:

               -  Age over 18 years

               -  No diagnosis of essential tremor

               -  Written informed consent

               -  Subject covered by the French health insurance system

        Exclusion Criteria:

          -  Patient:

               -  Dementia (MMSE<24) or other known illness which could impact motor and cognitive
                  performances

               -  Patient unable to give written informed consent

          -  Control:

               -  Same exclusion criteria as for patients
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric Diseases

Eligibility criteria:
Inclusion Criteria:

          -  Patients presented with gastric symptoms and ready for the first Upper GI endoscopy

          -  Patients with known focal gastric diseases: gastric ulcer, gastric polyps, early
             gastric cancer, gastric stromal tumors and so on.

          -  Age of 18 years to 70 years

        Exclusion Criteria:

          -  Patients with impaired bowel movement from ileus or organic digestive diseases

          -  Patients with known large and obstructing tumors of the upper GI tract

          -  Patients after upper GI surgery or abdominal surgery altering GI anatomy

          -  Patients under full anticoagulation

          -  Patient in poor general condition

          -  Patients using equipment that may be affected by radio transmission

          -  Patients using equipment that may be affected by magnetic field

          -  Pregnancy or suspected pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Health Effects of SLT, Cigarette Smoking, and New Tobacco Products

Eligibility criteria:
Inclusion Criteria:

          -  Subjects between 18-70 years of age

          -  Smoking at least 10 cigarettes/day for at least one year

          -  Good physical and mental health as evidenced by a medical history with no unstable
             medical conditions.

        Exclusion Criteria:

          -  Uncontrolled chronic disease or condition that requires medical attention during the
             course of the study

          -  Contraindications for nicotine replacement products: active ulcers, recent heart
             attack, heart disease or irregular heart beat, uncontrolled high blood pressure, or
             medication use that might affect tobacco use

          -  Current unstable psychiatric diagnoses or persons who currently are adjusting
             medication dose. (within the last 3 months)

          -  Subjects with current or recent (within 6 months) alcohol or drug abuse problem

          -  Other regular tobacco use such as regular cigar or pipe smoking

          -  Currently using other nicotine replacement products

          -  Chronic use of any drug that could interact with the study drugs.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction