Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility

Eligibility criteria:
Inclusion Criteria:

          -  NOA patients undergoing ICSI with testicular sperm

          -  OA post-vasectomized patients undergoing ICSI with testicular sperm

        Exclusion Criteria:

          -  Abnormal Karyotype
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Overweight and Obesity and Puberty Development Cohort Study

Eligibility criteria:
Inclusion Criteria:

          -  Children over 6 years old from grade 1, 2 and 3 in selected primary schools in
             Zhongshan, Qufu and Huhhot since 2019

        Exclusion Criteria:

          -  Children with overweight or obesity had a history of hormone drug treatment last for 6
             months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Application Value of CTCs Detection for Advanced Gastric Cancer Patients

Eligibility criteria:
Inclusion Criteria:

        Subjects eligible for enrollment must meet all of the following criteria:

          1. Provide signed informed consent. The subject is capable of understanding and complying
             with parameters as outlined in the protocol and able to sign informed consent,
             approved by the Independent Ethic Committee (IEC)/Institutional Review Board (IRB)
             prior to the initiation of any study-specific procedures

          2. Men or women aged >= 18 years and <=75 years.

          3. Eastern Cooperative Oncology Group Performance Status (ECOG) <= 2.

          4. Histologically confirmed adenocarcinoma of the stomach, gastroesophageal junction.

          5. Metastatic disease or locally advanced disease not amenable to curative surgery.

          6. Radiographically assessable, non-measurable disease or measurable disease as per
             RECIST criteria.

          7. Life expectancy of at least 12 weeks with tumor and at least 5 years without tumor
             from the time of enrollment.

          8. No other malignancy within the past 5 years except adequately treated basal cell or
             squamous cell skin cancer or carcinoma in situ of the cervix.

          9. No prior chemotherapy for advanced disease. -

        Exclusion Criteria:

        Subjects meeting any of the following criteria must not be enrolled in the study:

          1. Gastric carcinoid, sarcomas, or squamous cell cancer.

          2. Pregnant or lactating females.

          3. Significant neurological or psychiatric disorders (psychotic disorders, dementia or
             seizures) that would prohibit the understanding and giving of informed consent.

          4. Active Hepatitis B or C or history of an HIV infection.

          5. Active uncontrolled infection. -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 403 in Subjects With Osteoarthritis Knee Pain

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with knee OA as determined by ACR criteria: Knee pain and radiographic
             osteophytes and at least 1 of the following 2 items: Morning stiffness 30 minutes,
             Crepitus on motion, a VAS pain score of ≥ 30 mm for index knee at screening,

        Exclusion Criteria:

          -  Weight of > 125 kg, Inflammatory arthropathy including secondary OA (eg, degenerative
             arthritis in patients with rheumatoid arthritis) as confirmed by a rheumatologist or
             investigator, Diagnosis of a condition other than knee OA that, in the investigator's
             opinion, may cause or affect pain or pain assessment in the index knee; these
             conditions may include but are not limited to radiculopathy or neuropathy,
             vasculopathy, fibromyalgia or active depression, Subjects taking neuromodulatory
             agents (antiepileptics or antidepressants) used as analgesic therapy for neuropathic
             pain
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Letrozole Versus Gonadotropins in Clomiphene Citrate Resistance

Eligibility criteria:
Inclusion Criteria:

          -  Infertility lasting one year or more in presence of regular intercourse,

          -  Patients' age between 20-35years

          -  Normal semen analysis according to WHO 2010

          -  Patent fallopian tubes (e) Normal prolactin and TSH.

          -  Anovulatory cycles confirmed by mid-luteal progesterone ≤ 3 ng/ml and

          -  Clomiphene citrate resistance for 3 cycles of 150mg.

        Exclusion Criteria:

          -  Any hormonal disturbances eg. hyperprolactinemia,

          -  Immunological causes of infertility,

          -  Coital errors,

          -  Metabolic disorders and

          -  Poor patient compliance.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Mitral Valve in Hypertrophic Cardiomyopathy

Eligibility criteria:
Inclusion Criteria:

          -  Age >18 years

          -  Signed informed consent to participate in the study

          -  For patients with hypertrophic cardiomyopathy only: resting or latent peak left
             ventricular outflow tract gradient >50 mmHg, NYHA class III-IV

          -  For patients with arterial hypertension only: hystory of arterial pressure increase
             >140/90 mmHg, increased left vantricular wall thickness (>10 mm) and myocardial mass
             indexed to BSA (>95 g/m2 for women and >115 g/m2 for men), as assessed by 2D
             transthoracic echocardiography

        Exclusion Criteria:

          -  Age < 18 years

          -  Persistent form of atrial fibrillation

          -  Intrinsic mitral or aortic valve disease

          -  Coronary artery disease

          -  Reduced left ventricular ejection fraction

          -  For control group only: presence of any structural heart disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Hypoxemia

Eligibility criteria:
Inclusion Criteria:

          1. Age > 18 years

          2. Positive COVID 19 test or clear clinical diagnosis of COVID-19. Positive COVID-19 test
             will be confirmed based on a PCR or antigen test result or patient reported history.
             Clear clinical diagnosis of COVID-19 will be a combination of respiratory symptoms and
             clinical findings based on laboratory values and radiographs.

          3. Moderate to severe hypoxemia defined by a baseline supplemental oxygen requirement of
             6 liters or higher (including high flow oxygenation devices) as measured within the 24
             hours before enrollment

        Exclusion Criteria:

          1. Pregnancy

          2. Untreated pneumothorax, which must be evaluated with a baseline chest radiograph or
             computerized tomography scan at least 72 hours prior to enrollment

          3. Presence of pneumomediastinum, pneumopericardium, significant subcutaneous emphysema,
             or pulmonary blebs, which should also be evaluated with a baseline chest radiograph
             prior to enrollment

          4. Current invasive mechanical ventilation

          5. Current non-invasive mechanical ventilation

          6. Any patient who will not be stable for transport to the hyperbaric chamber, in
             addition to any relative contraindications identified by the treating hyperbaric
             physician or inpatient hospital team (e.g., severely impaired cardiac output due to
             significant myocardial injury).

          7. Any patient without the capacity to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Behavioral Self-Help Intervention for Pediatric Atopic Dermatitis and Eczema Patients

Eligibility criteria:
Inclusion Criteria:

          1. children presenting to the pediatric dermatology clinic;

          2. current or new diagnosis of eczema or AD;

          3. between the ages of 4 and 12;

          4. excoriation is reported by the patient or parent or noted by the clinical staff to be
             a prominent issues within the past month.

        Exclusion Criteria:

          1. inability to complete English-language questionnaires;

          2. patients requiring systemic immunosuppressives such as systemic prednisone,
             methotrexate, azathioprine, mycophenolate mofetil, or cyclosporine;

          3. Patients with known comorbidities that cause immunodeficiency, such as HIV, treatment
             with chemotherapy, or genetic syndromes;

          4. Patients who are being treated by a mental health provider (e.g., counselor,
             psychologist) or psychiatrist for issues specifically related to excoriation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Aerobic Exercise in Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  5-12 years

          -  Male

        Exclusion Criteria:

          -  having any injury or surgery of the lower extremity

          -  having systemic and metabolic disease

          -  having behavioral and cognitive problems that prevent consistence to guidelines given
Male
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Entailment