Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Pacemaker Therapy for Drug-refractory Symptoms in Mid-cavity Hypertrophic Cardiomyopathy

Eligibility criteria:
Inclusion Criteria:

          1. Male or female, >18 years.

          2. Referred for PPM +/- ICD implantation for either primary prevention of sudden cardiac
             death or other indications such as heart block or obstructive physiology.

          3. HCM patients with a mid-cavity gradient of ≥30 mmHg demonstrated by echocardiography
             and gradient confirmed by cardiac catheterisation at rest or with isoprenaline
             provocation. HCM morphology confirmed by cardiac MRI.

          4. All patients should be taking maximum tolerated doses of beta blockers or verapamil
             with or without disopyramide.

          5. Symptoms refractory to optimum medical therapy as above, for example breathlessness,
             chest pain, dizziness, or syncope.

        Exclusion Criteria:

          1. Patients with multi-level obstruction, i.e. across the mid-cavity and outflow tract.

          2. Patients with moderate or severe valvular stenosis or regurgitation.

          3. Patients with a history of myocardial infarction or acute coronary syndrome.

          4. Patients unable to provide informed consent.

          5. Patients in atrial fibrillation.

          6. Pregnancy.

          7. Renal failure.

          8. If considered unsuitable by clinician.

          9. Patients already participating in trials involving invasive procedures.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Stimulation of Sensation and Improvement in Swallowing Using Oral Capsaicin

Eligibility criteria:
Inclusion Criteria:

          -  Patients older than 18 years of age

          -  Patients with the following condition: dysphagia, globus, gastroesophageal reflux,
             neurological disease affecting swallowing or any other condition requiring dynamic
             swallow study

          -  Patients willing to provide written informed consent for their participation in the
             study

        Exclusion Criteria:

          -  Patients unable to complete a full dynamic swallow study protocol

          -  Patients enrolled in another investigational clinical trial that interferes with any
             testing or testing results

          -  Patients who are pregnant

          -  Patients with known sensitivities or allergies to capsaicin or peppers, or nightshades
             (tomato, bell pepper, eggplant) or latex

          -  Patients who are prisoners

          -  Patients who are unable to keep a capsaicin lozenge in their mouth safely for 5
             minutes
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis (IPF)

Eligibility criteria:
Inclusion Criteria:

          -  18 years of age or older

          -  Diagnosis of pulmonary fibrosis confirmed by physical examination, pulmonary function
             testing, chest X-ray, and computed tomography (CT) scans.

          -  Adult patients who are seeking treatment at the Dorothy P. and Richard P. Simmons
             Center for Interstitial Lung Disease.

        Exclusion Criteria:

          -  Under 18 years of age

          -  Non-fibrotic ILD
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Study to Determine the Effectiveness of Endoscopic Full-Thickness Plication for the Treatment of GERD

Eligibility criteria:
Patients 18 years or older with a history of heartburn or regurgitation symptoms requiring
        daily PPI therapy were recruited.

        Inclusion Criteria:

          -  GERD-HRQL score ≥ 15 while off PPI therapy, and at least 6 points higher than on-PPI
             score

          -  Pathologic esophageal acid exposure, defined as pH<4.0 ≥ 4.5% of a 24- or 48-hour
             monitoring period or a DeMeester score > 14.7

          -  Lower esophageal resting pressure of at least 5mmHg; and

          -  Suitability for surgery (American Society of Anesthesiologists Physical Status
             Classification I or II).

        Exclusion Criteria:

          -  Significant esophageal dysmotility as determined by manometry

          -  Esophagitis grade III or IV (Savary-Miller)

          -  Barrett's epithelium

          -  Hiatus hernia > 2cm

          -  Persistent dysphagia, weight loss, esophageal bleeding, vomiting, gas or bloating

          -  Esophageal or gastric varices

          -  Previous endoscopic or surgical anti-reflux procedure

          -  Other esophageal or gastric surgery

          -  Chronic use of anticoagulant or platelet anti-aggregation therapy (other than for
             cardiac prophylaxis); and

          -  Pregnancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Study on the Effectiveness of Laparoscopic Fundoplication on Extraesophageal Manifestations of Gastroesophageal Reflux Disease (GERD)

Eligibility criteria:
Inclusion Criteria:

          -  persistent or recurrent symptoms despite continuous medical treatment, at least one
             typical reflux symptom (heartburn/ regurgitation/dysphagia/epigastric pain) and/or at
             least one atypical reflux symptom (cough/ asthma/hoarseness/distortion of taste),
             pathologic esophageal acid exposure as documented by a reflux-related DeMeester score
             ≥14.7, and symptom correlation ≥50%, and/or reflux episodes >73.

        Exclusion Criteria:

          -  previous esophageal or gastric surgery, poor physical status (American Society of
             Anesthesiologists (ASA) scores III and IV) and pregnancy.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Sjogrens Syndrome Measured by Ultrasound

Eligibility criteria:
Inclusion Criteria:

          -  Subjects diagnosed with Sjogren's Syndrome

        Exclusion Criteria:

          -  Subjects previously diagnosed with Sarcoidsis

          -  Subjects with positive for Hepatitis B, Hepatitis C, HIV

          -  Subjects diagnosed with Cancer within 5 years of screening
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Modified Thoracoscopic Pleural Cryobiopsy in Diagnosis of Exudative Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Adult patient with undiagnosed exudative pleural effusion

        Exclusion Criteria:

          -  Any contraindications to medical thoracoscopy like:

        Inability to tolerate lateral decubitus position Unstable cardiovascular or hemodynamic
        status Presence of severe, uncorrectable hypoxemia despite oxygen therapy Bleeding
        diathesis Refractory cough Drug Hypersensitivity Reduced general health status with short
        suspected survival

          -  Refusal to participate
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Patient Education in Gastroesophageal Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  heartburn and acid regurgitation the dominant symptom

          -  needing relief at least 5 days/ week when symptoms were at their worst

          -  disease history at least 3 months

          -  ability to give informed consent

        Exclusion Criteria:

          -  current or previous esophagitis stage 2(Savary-Miller) or greater or peptic ulc

          -  continuous need of proton pump inhibitors or NSAIDs

          -  wish for surgical treatment

          -  earlier surgical treatment in the GI-tract

          -  pregnancy

          -  alcohol or drug abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Myography

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of probable or definite ALS by the El Escorial Criteria

        Exclusion Criteria:

          -  History of superimposed generalized neuromuscular disease

          -  Primary lateral sclerosis or other atypical motor neuron disorders

          -  Forced vital capacity of less than 50%

          -  Presence of disease for greater than 5 years since symptom onset
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal women: no reported change in menstrual cycle pattern

          -  Early peri-menopausal women: reported change in menstrual cycle frequency in preceding
             year with a bleed in the preceding 3 months

          -  Late peri-menopausal women: no menses in the preceding 3-11 months

          -  Postmenopausal women: no menses in the preceding 12 months

          -  Patients who received oophorectomy

          -  Patients who received hysterectomy for benign uterus tumor

          -  Patients underwent assisted reproductive technology (ART).

        Exclusion Criteria:

          -  Patients underwent chemotherapy or radiotherapy in past two years
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment