Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Clinical Outcome Measures in Myotonic Dystrophy Type 2

Eligibility criteria:
Inclusion Criteria:

          -  Genetically confirmed myotonic dystrophy type 2

          -  Able to provide informed consent

        Exclusion Criteria:

          -  Invalidating diseases not related with DM2 (e.g. Stroke).

          -  Subject participating in another clinical trial (other than registries) concurrently
             or within 30 days prior to screening for entry into this study.

          -  Unable to complete study questionnaires.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of moderate or severe classic essential tremor (bilateral, largely symmetric
             postural or kinetic tremor involving hands and forearms.

          -  Willingness to abstain from ethanol and caffeine intake for at least 48 hours prior to
             Days 1 and 4 and on inpatient days

        Exclusion Criteria:

          -  Subjects with a clinically significant unstable medical abnormality, chronic disease
             or history or presence of significant hepatic, renal, endocrine, cardiovascular,
             gastrointestinal, pulmonary, psychiatric, or metabolic disease or any other
             abnormality

          -  Subjects who are on sodium-restricted diets

          -  Subjects with a known history of sleep apnea
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Ages 20-75

          -  Unilateral or bilateral knee osteoarthritis (OA), confirmed radiographically.

          -  Patients taking oral non-steroidal anti-inflammatory drugs (NSAIDs) in the amount and
             schedule prior to the breakthrough period will be permitted.

        Exclusion Criteria:

          -  Patients with clinical history of anterior cruciate ligament (ACL) involvement.

          -  Patients on tricyclic antidepressants or anticonvulsants (neuropathic medications)

          -  History of ulcers or gastrointestinal (GI) bleeding

          -  Coagulation disorders

          -  Hypersensitivity to Aspirin or NSAIDS

          -  Congestive Heart Failure and Edema

          -  Advanced renal disease

          -  Aspirin triad

          -  Pregnant women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Hernia Surgery Urinary Retention

Eligibility criteria:
Inclusion Criteria:

          -  Male

          -  18 years of age

          -  Presenting with hernia requiring surgical intervention

        Exclusion Criteria:

          -  Intolerability of tamsulosin or related drugs

          -  Investigator discretion

          -  Unwillingness or inability to comply with protocol procedures and assessments
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Eplerenone for Subclinical Cardiomyopathy in Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  DMD patients age 7 years and older (and able to complete cardiac MRI without sedation)
             with preserved left ventricular (LV) systolic function and abnormal heart muscle by
             late post-gadolinium imaging (LGE)

        Exclusion Criteria:

          -  renal insufficiency (GFR <40 mL/min/m2)

          -  non-MR compatible implants (e.g. neurostimulator, AICD)

          -  severe claustrophobia

          -  allergy to gadolinium contrast

          -  prior use of or known allergy to epleronone

          -  use of potassium-sparing diuretics

          -  serum potassium level of >5.0 mmol/L
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Colorado Adult Joint Assessment Scale (CAJAS) Validation

Eligibility criteria:
Inclusion Criteria:

          -  Male, 18 to 50 years of age

          -  Diagnosis of moderate to severe hemophilia A (documented <1-2% Factor VIII
             Concentration [FVIII:C])

          -  Willing to maintain current FVIII treatment regimen, whether prophylactic or
             on-demand, for the duration of the study

        Exclusion Criteria:

          -  Routine need for wheelchair or routine need for two canes or crutches

          -  Diagnosis of another bleeding disorder such as von Willebrand Disease

          -  Known event that would interfere with the scheduled CAJAS evaluations (e.g., elective
             joint surgery, vacation)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Cyclic Deep Brain Stimulation in Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          1. Participant is at least 18 years of age

          2. Participant has confirmed diagnosis of medically-refractory essential tremor

          3. Participant meets criteria for implantation of DBS system

          4. Participant understands the study requirements and treatments procedures and provides
             informed consent before any study-specific tests or procedures are performed

        Exclusion Criteria:

          1. Participant meets any contraindications for implantation of DBS system

          2. Participant is undergoing or has had previous thalamic stimulation either in a
             research trial or with a permanent implant

          3. Participant is unwilling or unable to comply with all study required follow-up
             evaluations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis

Eligibility criteria:
Inclusion Criteria:

          -  Male and female patients >18 years

          -  Diagnosis of Takayasu's arteritis or giant cell arteritis

          -  Suspicion of common carotid involvement on the basis of physical examination (cervical
             bruit), carotidynia, documented CCA involvement on an imaging study (MRA, CTA, or
             ultrasound), or documented upper extremity large vessel involvement on an imaging
             study (MRA or CTA or ultrasound).

          -  Ability to provide informed consent

        Exclusion Criteria:

          -  Prior stroke, carotid surgery or angioplasty

          -  Pregnant (or trying to become pregnant)

          -  Nursing

          -  Known or suspected cardiac shunt

          -  Documented hypersensitivity to the contrast agent

          -  Severe pulmonary hypertension or unstable cardiopulmonary conditions (acute myocardial
             infarction, acute coronary artery syndromes, worsening or unstable congestive heart
             failure, serious ventricular arrhythmias, or respiratory failure)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

        - Patients were diagnosed with ALS recruited from all participant clinical centers.The
        diagnosis of ALS was made using the revised El Escorial criteria for definite, probable,
        lab-supported, and possible.

        Exclusion Criteria:

          -  Decline to follow-up.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Minimal Change Esophagitis by i-Scan Endoscopy in Dyspeptic Patients

Eligibility criteria:
Inclusion Criteria:

          -  Patients with one or more of the following symptoms namely epigastric pain or
             discomfort, postprandial fullness and early satiety with or without symptoms
             suggesting GERD

          -  Patients able to give informed consent

        Exclusion Criteria:

          -  Patients with significant weight loss.

          -  Patients with hematemesis, melena ,dysphagia, intractable vomiting , palpable
             abdominal mass.

          -  Patients with history of documented peptic ulcer , gastric surgery , gastric cancer.

          -  Patients with symptoms compatible with irritable bowel syndrome, hepatobiliary tract
             disease.

          -  Patients with severe concomitant medical conditions, pregnant woman or continuous
             usage of steroids or NSIADS in the preceding 1 month before entry to the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission.

Eligibility criteria:
Inclusion Criteria:

        - All consecutive patients meeting the 1990 ACR classification criteria for GCA.

        Exclusion Criteria:

          -  Corticosteroid treatment during the previous 6 months.

          -  Uncontrolled diabetes.

          -  Uncontrolled hypertension.

          -  History of cancer within the past 5 years.

          -  History of frequent infections in the past.

          -  Positivity of screening procedures for latent tuberculosis infection.

          -  Uncontrolled dyslipidemia at baseline.

          -  Known intestinal diverticulosis.

          -  Concomitant hematologic disorders.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment