Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Use of Gcsf in Patients With Recurrent Ivf/Icsi Failure

Eligibility criteria:
Inclusion Criteria:

          -  male partner with normal semen analysis according to world health organization (WHO)
             2010.

          -  female partner under the age of 36 presented with: a-thin endometrium (less 7 mm on
             transvaginal ultrasound) or b- previous history multiple unexplained

          -  female with no history of Asherman's syndrome , fibroids, and polyps in diagnostic
             hysteroscopy

        Exclusion Criteria:

          -  women with sickle cell disease, renal insufficiency, upper respiratory infection or
             pneumonia, chronic neutropenia, known past or present malignancy
Female
No healthy subjects accepted to join the trial.

Subject must be at most 36 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Intestinal Phosphate Transporter Expression in CKD Patients

Eligibility criteria:
Inclusion Criteria:

          -  Upper endoscopy for suspected or known esophageal or gastric pathology

          -  Upper endoscopy for screening purposes

          -  Written consent to take part in the study

        Exclusion Criteria:

          -  Food intake within 8 hours prior to the endoscopy

          -  Major duodenal pathology, in particular duodenitis or duodenal ulcers or tumor

          -  Contraindication to duodenal biopsy such as bleeding disorder

          -  Treatment with medication known to regulate the expression or activity of intestinal
             phosphate transporters (e.g. nicotinamide)

          -  Kidney transplant patients

          -  Alcohol or drug abuse

          -  Mental condition rendering the subject unable to understand the nature, scope and
             possible consequences of the study

          -  Participation in a parallel clinical trial

          -  Subjects who are in any state of dependency to the sponsor or the investigators

          -  Employees of the sponsor or the investigators

          -  Subjects who have been committed to an institution by legal or regulatory order
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Human Lung Responses to Respiratory Pathogens

Eligibility criteria:
Inclusion Criteria:

        Signed informed consent form Age 18 - 60 Healthy nonsmoker, healthy smoker Forced
        expiratory volume in 1 second (for smokers) > 60% predicted.

        Exclusion Criteria:

          -  Pregnant or breastfeeding

          -  Medications (with the exception of hormonal birth control, thyroid medication or
             prespecified over the counter medications), including multi-vitamins and any
             preparation that contains vitamin D

          -  Asthma

          -  Heart disease

          -  Diabetes

          -  Previous positive tuberculin skin test, or previous diagnosis of tuberculosis

          -  Recent respiratory tract infection

          -  History of multiple bouts of pneumonia

          -  Allergies to caines, atropine, or a history of adverse reaction to narcotics

          -  Other factors that increase the risk of bronchoscopy

          -  Evidence of acute bronchitis within the past 2 weeks
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Assessment of Skeletal Muscle Dysfunction in Patient With Idiopathic Pulmonary Fibrosis

Eligibility criteria:
Inclusion Criteria:

          -  All patient who will be presented to assuit chest department and diagnosed as IPF.

        Exclusion Criteria:

          -  1-IPF patient with malignant tumors. 2-Comorbid end stage renal, cardiac or hepatic
             patient. 3-patient who refused to participate in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient's own account: My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Clinical trial: the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Infants were confirmed to have Down syndrome of non disjunction genotype.

          -  Age was around 6 month, at time of recruitment.

          -  Legal guardians accepted to participate in the study and sign the informed consent.

        Exclusion Criteria:

          -  Patients having uncontrolled hypothyroidism

          -  Patients with brain malformations other than the expected in infant with Down
             syndrome.

          -  Patients with hearing and / or vision impairments.

          -  severe congenital heart disease

          -  Patients having contraindications for the use of Cerebrolysin
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.
Subject must be at most 7 Months

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Handheld Ultrasound (HHUS) for Home Use in Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Severe hemophilia A

          -  Male

          -  Over 18 years of age

          -  Able to read, write and understand English

          -  Willing to come to the center for an 8 hour training session

          -  Lives in proximity of the HTC and is willing to come in for acute joint episodes in
             phase 2

          -  Willing and able to follow study procedures

          -  Willing and able to keep HHUS at a safe place

          -  Have the dexterity to operate a HHUS unit

        Exclusion Criteria:

          -  Unable to follow study instructions

          -  Physically or mentally unable to operate a HHUS unit
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Prevention Among Young People With Intellectual Disability

Eligibility criteria:
Inclusion Criteria:

          -  Students with mild or moderate ID with informed consent can be included

          -  Understand and respond to a questionnaire

        Exclusion Criteria:

        - Students with severe ID
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Study Evaluating TCH346 and Placebo Administered Once Daily in Patients With Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion criteria:

          -  clinical diagnosis of laboratory-supported probable, probable, or definite ALS;

          -  sporadic or familial ALS;

          -  ALS symptom onset for no more than 3 yrs at study entry;

          -  FVC equal to or more than 70%;

          -  patients who are either riluzole naive or patients who are receiving concomitant
             treatment with riluzole at a stable dose of riluzole (50 mg bid) at study start.

        Exclusion criteria:

          -  Known or suspected chronic infectious disease including HIV, hepatitis B, or hepatitis
             C.

          -  Clinically significant ECG abnormalities.

          -  Known hypersensitivity to study drug or related drugs (e.g. selegiline, MAO-A and B
             inhibitors, or tricyclic antidepressants).

          -  Patients treated with potent inhibitors of CYP1A2 or CYP3A4 (a list of such inhibitors
             will be provided to the investigator).

          -  Treatment with MAO-A and B inhibitors (including selegiline) within the past 30 days.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Thales Thermography Triage (3T) - Pilot Project

Eligibility criteria:
Inclusion Criteria:

          -  Patients ≥ 16 years old with no upper age limit

          -  Patients able to read and understand English

          -  Patients able to give informed consent

          -  Patients being triaged through ED for any complaint, not necessarily COVID-19 QEUH ED
             staff

        Exclusion Criteria:

          -  Patients not meeting the inclusion criteria

          -  Patients who do not have capacity to consent

          -  Patients attending ED who are fast-tracked without triage
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Comparison of Different Meshes in Laparoscopic Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Age≥18

          -  Unilateral inguinal hernia with large hernia defect size (>3cm)

          -  Bilateral inguinal hernias

          -  American Society of Anesthesiologists (ASA) score: 1-2

          -  Provision of written informed consent

        Exclusion Criteria:

          -  Any prior surgery for ipsilateral inguinal hernia (i.e. recurrent inguinal hernia)

          -  American Society of Anesthesiologists (ASA) score: 3 or above

          -  History of major abdominal surgery that may result in difficulty in development of
             preperitoneal space

          -  Subject is pregnant or breast feeding

          -  Any serious concomitant illness with short life expectancy

          -  Subject who is not able to attend follow up postoperatively
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment