Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: The Outcomes of ICSI Cycles With and Without Letrozole

Eligibility criteria:
Inclusion Criteria:

        Women aged from 18 - 40 years old.

          -  Regular menstrual cycle (25-35).

          -  Women undergoing ICSI cycle

        Exclusion Criteria:

        Women younger than 18 or older than 40 years old.

          -  Women who had unilateral oophorectomy.

          -  Women who had uterine abnormality or pathology.

          -  Women who will not meet the inclusion criteria.

          -  Women who will refuse to participate in in the study.

          -  ICSI cycles with fresh or frozen TESE samples.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of EsoDuo Tab. 20/800mg

Eligibility criteria:
Inclusion Criteria:

          1. Male or Female aged ≥ 19 years

          2. Episode of heartburn for 3 months or more during prior to randomization visit.

          3. Episode of heartburn for 2 days or more during the last 7 days prior to randomization
             visit.

          4. Grade N, M by EGD test.

        Exclusion Criteria:

          1. Surgery history on stomach or esophagus

          2. Active medical history of stomach, esophagus area

          3. Other system disorder which can disturb this trial

          4. Patients taking the contraindication of concomitant medications

          5. Clinically significant Abnormal Lab test

          6. Pregnant woman, Breastfeeding woman.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Postural Analysis in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Osteoarthritis Disease

        Exclusion Criteria:

          -  Others Disease orthopedics
Female
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Safety and Efficacy of Iron Reduction by Phlebotomy

Eligibility criteria:
Inclusion Criteria:

          -  consecutive patients who have undergone autologous or allogeneic HSCT

          -  who are red-cell transfusion-independent

          -  at least 60 days post-transplant

          -  serum ferritin of at least 1000ug/L

          -  ECOG less than or equal to 2.0

        Exclusion Criteria:

          -  pregnancy

          -  breast-feeding

          -  serious infection

          -  HIV antibody positive

          -  renal failure (creatinine < 30ml/min)

          -  sever obstructive lung disease

          -  have a pacemaker, cerebral aneurysm or metal prosthesis

          -  evidence of disease relapse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Study of the Long-term Effects of Exercise on Heath Indicators in Older People

Eligibility criteria:
Inclusion Criteria:

          -  Older adults living independently;

          -  medical approval.

        Exclusion Criteria:

          -  Non-smokers;

          -  Non-morbidly obese;

          -  No history of severe hypertension;

          -  No history of falls;

          -  No orthopaedic, neurological, pulmonary, or cardiac problems.
Male
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 79 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: RCT: WLE vs. NBI in Upper Gastrointestinal Endoscopy

Eligibility criteria:
Inclusion Criteria:

          1. Subjects aged > 50 years undergoing diagnostic or screening upper GI endoscopy

          2. ability to provide a written consent to trial participation.

        Exclusion Criteria:

          1. presence of active gastrointestinal bleeding

          2. presence of coagulopathy precluding biopsies

          3. absence of informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Efficacy Study of AGSPT201 Tablet to Treat Gastroesophageal Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  aged 18~75 years

          -  Patients whose esophageal lesions graded over LA A grade (The severity of lesions is
             classified by LA classification)

          -  Patients whose typical reflux symptoms such as heartburn, acid regurgitation, acid
             reflux and esophagus irritation during the past 3 month

          -  Symptoms on at least 2 days of the past 7 days

        Exclusion Criteria:

          -  PPI treatment within 4 weeks before dosing or treatment of H2 blocker, sucralfate,
             prokinase NSAID (except low dose aspirin) within 2 weeks before dosing.

          -  Patients whose history of GI tract resection or vagotomy.

          -  Barrett's oesophagus greater than 3cm in length and high-grade dysplasia.

          -  Acid irrelevant Heartburn and regurgitation.

          -  Zollinger Ellison syndrome

          -  Hypersensitive and/or allergy to Pantoprazole and/or other PPI

          -  Pregnancy and lactation

          -  peptic ulcer

          -  serious hepatic

          -  any other renal, cardiac or haematological disease.

          -  Patients participated any other clinical studies during the past 3 months.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Assessment and Treatment of Patients With Long-term Dizziness in Primary Care

Eligibility criteria:
Inclusion Criteria:

          -  The dizziness is provoked or aggravated by head movements, more than 3 months duration
             og symptoms, the dizziness started acute, understand Norwegian

        Exclusion Criteria:

          -  Dizziness no longer a problem, other known reasons, than vestibular, for the dizziness
             (neurological, psychological, or cancer), fluctuating vestibular disease (e.g,
             ménierès disease), scheduled for treatment of/ have had treatment for benign
             paroxysmal positional vertigo within one month,conditions where fast head movements
             are contraindicated (e.g. osteoporisis of the neck, whiplash associated injuries),
             participated in group therapy for dizziness within the past year, unable to attend
             test and treatment locations
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: STI/HIV Prevention Intervention for Adolescents in Singapore

Eligibility criteria:
Inclusion Criteria:

          -  Singaporean citizens or permanent residents

          -  Sexually active for the past 1 year

          -  Heterosexual

          -  Attending the clinic for the first time

          -  Able to commit for one year in Singapore

        Exclusion Criteria:

          -  Involved in criminal investigation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.
Subject must be at most 19 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Cardiomyopathy in DMD: Lisinopril vs. Losartan

Eligibility criteria:
Inclusion Criteria:

          -  Duchenne muscular dystrophy patients of all ages

          -  Null mutation of the dystrophin gene or muscle with <5% dystrophin

          -  Doppler echocardiogram with ejection fraction (EF) <55% within 30 days of enrollment

          -  Ability to cooperate for testing

          -  Glucocorticoid treatment acceptable including daily or weekend administration of
             prednisone or deflazacort

        Exclusion Criteria:

          -  Patients with EF 55% or greater

          -  Patients with EF <40% after washout

          -  Patients taking >5 mg lisinopril, or >25 mg losartan or >5 mg enalapril

          -  Skeletal deformities or pulmonary anatomical variants that preclude consistent
             measures of Doppler echocardiography
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: The Effect of Lactobacillus Reuteri ATCC PTA 6475 on Volumetric Bone Mineral Density in Patients With Osteopenia

Eligibility criteria:
Inclusion Criteria:

          -  bone mineral density T-score less than -1 but more than -2.5 in the total hip or
             femoral neck or lumbar spine (L1-L4) by dual energy x-ray absorptiometry

          -  signed informed consent

          -  stated availability throughout the entire study period

          -  mental ability to understand and willingness to fulfill all the details of the
             protocol

        Exclusion Criteria:

          -  untreated hyperthyroidism

          -  rheumatoid arthritis

          -  diagnosed with disease causing secondary osteoporosis within the last year, including
             primary hyperparathyroidism, chronic obstructive pulmonary disease, inflammatory bowel
             disease, celiac disease, or diabetes

          -  recently diagnosed malignancy (within the last 5 years)

          -  per oral corticosteroid use

          -  use of antiresorptive therapy, including systemic hormone replacement therapy,
             bisphosphonates, strontium ran elate

          -  use of teriparatide (current or during the last 3 years)

          -  participation in other clinical interventional trials

          -  use of antibiotics within 2 months preceding the inclusion
Female
Accepts Healthy Volunteers
Subject must be at least 75 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction