Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Evaluating the Impact of Patient Photographs for Preventing Wrong-Patient Errors

Eligibility criteria:
Inclusion Criteria:

          -  All patients for whom an order was placed in the study period.

          -  All providers with the authority to place electronic orders and who placed electronic
             orders during the study period.

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Efficacy of Pantoprazole in Patients Older Than 18 Years Who Have Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/M3-339)

Eligibility criteria:
Main Inclusion Criteria:

          -  Outpatients

          -  Reflux disease-related symptoms for at least 12 weeks, which need not be consecutive,
             in the previous 12 months or endoscopically confirmed reflux esophagitis grade A to D,
             according to LA-classification

        Main Exclusion Criteria:

          -  Regular intake of systemic glucocorticosteroids, NSAIDs including COX-2 inhibitors on
             >3 consecutive days per week within the previous 28 days; exception: regular intake of
             acetylsalicylic acid up to a daily dose of 150 mg/day

          -  Intake of PPIs (proton pump inhibitor) during the last 10 days, of histamine
             2-receptor antagonists or prokinetics during the last 5 days, intake of sucralfate
             during the last 2 days before the start of the study

          -  Intake of PPIs in combination with antibiotics for eradication of H. pylori during the
             last 28 days prior to study start

          -  Eradication of H. pylori during the last 28 days prior to study start

          -  Acute peptic ulcer and/or ulcer complications
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Woodsmoke Exposure and Cardiovascular Function

Eligibility criteria:
Inclusion Criteria:

          -  Healthy volunteers

        Exclusion Criteria:

          -  Use of regular medication except the oral contraceptive pill

          -  Current smokers

          -  Significant occupation exposure to air pollution

          -  Intercurrent illness
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Deoxycholic Acid Injection for the Treatment of Superficial Lipomas

Eligibility criteria:
Inclusion Criteria:

          -  One or more lipomas, based on clinical diagnosis, which are accessible for treatment
             and assessment, are quantifiable along at least 2 perpendicular diameters, and have
             the following characteristics:

               -  History of slow growth followed by dormancy, and stable for at least 6 months.

               -  Greatest length by greatest perpendicular width between 1 and 16 square
                  centimeters, inclusive

               -  Discrete, oval to rounded in shape, not hard or attached to underlying tissue

               -  Located on the trunk, arms, legs, or neck

          -  Stable body weight with a body mass index of less than 30 kg/m²

          -  Signed informed consent

        Exclusion Criteria:

          -  Absence of significant medical conditions that could affect safety

          -  History of surgical treatment for lipomas

          -  Treatment with an investigational agent within 30 days before ATX-101 treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          1. Age greater than 16 yr

          2. Diagnosed as idiopathic hypogonadotropic hypogonadism with clinical signs or symptoms
             of hypogonadism

          3. Hypogonadal serum testosterone levels (<166ng/dl) in the presence of low or normal
             gonadotropins

          4. Normal levels of other anterior pituitary hormones

          5. Normal MRI scans of the hypothalamo-pituitary region

          6. Had discontinued any prior treatment (testosterone or gonadotropin therapy) for at
             least three months before enrollment

        Exclusion Criteria:

          1. With any significant medical condition (including malignant disease), laboratory
             abnormality, or psychiatric disorders that will prevent the subject from participating
             in the study

          2. Congenital hypopituitarism

          3. Any medical or surgical conditions possibly affecting the experiment result

          4. Any clinically significant allergic diseases or allergic to the study drugs

          5. Recently drug or alcohol abuse(>35unit/week,1unit=8 g alcohol@1 standard drink@250ml
             beer@140ml wine@25ml strong alcohol drink like whiskey.)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: A Study (Study 2) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea

Eligibility criteria:
Inclusion Criteria:

          1. Moderate-to-severe rosacea (as per the IGA score) on the proposed facial treatment
             area consisting of:

               1. At least 15 and not more than 75 facial papules and pustules, excluding lesions
                  involving the eyes and scalp;

               2. No more than 2 nodules on the face.

          2. Presence of or history of erythema and/or flushing on the face.

        Exclusion Criteria:

          1. Presence of any skin condition and/or Excessive facial hair, on the face that would
             interfere with the diagnosis or assessment of rosacea.

          2. Moderate or severe rhinophyma, dense telangiectasia (score 3, severe), or plaque-like
             facial edema.

          3. History of hypersensitivity or allergy to minocycline, any other tetracycline, or of
             any other component of the formulation.

          4. Active ocular rosacea (eg, conjunctivitis, blepharitis, or keratitis) of sufficient
             severity to require topical or systemic antibiotics.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Study of Paraesophageal Hernia Repair With Small Intestine Submucosa

Eligibility criteria:
Inclusion criteria:

          -  Prior enrollment in Phase I study.

        Exclusion criteria:

          -  None.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Testosterone Therapy in Hypogonadal Men Treated With Opioids

Eligibility criteria:
Inclusion Criteria:

          -  Male patients 18-75 years

          -  Treatment with opioid for >3 months, daily dose >50-100 mg

          -  Total testosterone < 12 mmol/L

          -  Follicle Stimulating Hormone (FSH)/Luteinizing Hormone (LH) levels normal og below
             normal laboratory values

          -  Normal prolactin levels

        Exclusion Criteria:

          -  Hematocrit> 54% at screening

          -  Prostate Specific Antigen (PSA) > 3 ng/ml

          -  Severe organic and mental disease

          -  current or present cancer diagnosis

          -  Previous venous thrombotic embolism and cerebrovascular disease

          -  Uncontrolled hypertension

          -  Epilepsy or migraine not adequately controlled by therapy

          -  Severe benign prostate hypertrophy with symptom score >19

          -  Sleep apnea

          -  Alcohol or drug abuse

          -  Implantation of sustained action sex hormone in the last 12 months

          -  Use of oral, buccal or transdermal testosterone in the last two weeks

          -  Treatment with glucocorticoids > 5 mg/day or 5 alfa reductase inhibitors

          -  Hypersensitivity to Nebido
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Injection Therapy in Patients With Lateral Epicondylitis

Eligibility criteria:
Inclusion Criteria:

          1. aged 20-60 years,

          2. had a clinical diagnosis of lateral epicondylitis, defined as pain over the lateral
             humeral epicondyle of at least 6 months' duration,

          3. provoked by palpation and resisted wrist/middle finger extension or gripping,

          4. participants needed to score at least 30/100 on Visual analogue scale (VAS),

          5. be able to understand enough Turkish to complete the outcome questionnaire.

        Exclusion Criteria:

          1. Any treatment for their elbow pain by a health care practitioner within the preceding
             6 months,

          2. Concomitant neck or other arm pain causing disability or requiring treatment within
             the last 6 months,

          3. Clinical evidence of other primary sources of lateral elbow pain,

          4. Upper limb fractures within the preceding 10 years,

          5. Prior elbow surgery

          6. Elbow steroid injection in the past 3 months

          7. Systemic inflammatory disorder or malignancy,

          8. Pregnancy or breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Self Fixating Versus Stapled Mesh for Laparoscopic Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Age >18

          -  Demonstrated to have primary or recurrent unilateral or bilateral inguinal hernia

          -  Both patient and surgeon occupy a position of equipoise over the relative merits of
             either intervention

          -  Ability to give informed written consent

        Exclusion Criteria:

          -  Non-elective acute presentation with inguinal hernia and its complications

          -  Inability to give informed written consent

          -  Groin symptoms which on clinical examination and radiological investigations fail to
             demonstrate any evidence of inguinal hernia.

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment