Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Phase I Study of the Third Generation Adenovirus H5.001CBCFTR in Patients With Cystic Fibrosis

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

        --Disease Characteristics-- Cystic fibrosis diagnosed as follows: Sweat sodium or chloride
        greater than 60 mEq/L by pilocarpine iontophoresis or cystic fibrosis genotype Clinical
        manifestations Estimated 2-year survival greater than 50%, i.e.: FEV1 at least 30% of
        predicted PaO2 greater than 55 mm Hg on room air PaCO2 less than 50 mm Hg on room air
        --Prior/Concurrent Therapy-- At least 2 months since systemic glucocorticoids At least 90
        days since participation in investigational therapeutic study --Patient Characteristics--
        Pulmonary: No pneumothorax within 12 months No asthma or allergic bronchopulmonary
        aspergillosis requiring glucocorticoids within 2 months No sputum pathogens unless
        sensitive to at least 2 antibiotics No hemoptysis of more than 250 mL blood over 24 hours
        within 1 year Other: No active adenoviral infection Ad5 (or similar type) antibody
        seropositive No other contraindication to protocol participation, e.g.: Drug abuse
        Alcoholism Psychiatric instability Inadequate motivation Documented azoospermia (men)
        Bilateral tubal ligation or hysterectomy (women) Screening exams within 4 weeks prior to
        registration
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease

Eligibility criteria:
Inclusion Criteria:

          -  a healthy adult

          -  clinical diagnosis of ALS

          -  baseline FVC >60% predicted for age, sex and height.

        Exclusion Criteria:

          -  pregnant

          -  diagnosed cardiovascular disease

          -  a BMI >35 kg/m2

          -  currently take selective serotonin reuptake inhibitors (SSRI)

          -  history of seizures

          -  history of hospitalization for sepsis

          -  respiratory infection or took antibiotic medications within the past 4 weeks

          -  use external respiratory support during any waking hours

          -  participate in a pharmaceutical trial to treat ALS

          -  have any other medical condition the PI or medical director identify would make it
             unsuitable to participate.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  symptoms suggestive of GERD or dyspepsia.

          -  Presence of symptom for longer than 6 month

          -  Provision of written informed consent

        Exclusion Criteria:

          -  Any known upper GI disease, other than reflux esophagitis

          -  Active or healing gastroduodenal ulcer (except scars)

          -  History of esophageal or gastric surgery.

          -  Clinically significant heart, lung, liver or kidney disease

          -  Allergy to proton-pump inhibitor

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: The Use of Lactobacillus Reuteri in Functional Constipation in Children

Eligibility criteria:
Inclusion Criteria:

          -  Age 0.5 - 15 years

          -  Diagnosis of functional constipation according to Rome IV criteria

        Exclusion Criteria:

          -  Children with chronic diseases which could cause constipation: Celiac disease, food
             allergy, Hypothyroidism, Inflammatory Bowel Disease, electrolytes disturbances, Cystic
             fibrosis, Hirschsprung disease, Neuropathic conditions (Spinal cord trauma,
             Neurofibromatosis, Tethered cord) or intestinal pseudo-obstruction.

          -  Prematurity (< 34 weeks)

          -  S/P intestinal surgery

          -  Children treated with medications associated with constipation.

          -  Existing malignancy

          -  Primary or secondary immunodeficiency
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 15 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Tomotherapy Treatment for Mesothelioma

Eligibility criteria:
Inclusion Criteria:

          -  histologic mesothelioma

          -  refused/ineligible for surgery or chemotherapy

          -  life expectancy >3 months

        Exclusion Criteria:

          -  contraindications to thoracic radiotherapy

          -  unable to lie flat for duration of radiation therapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Clinical Characteristics of Critically Ill Patients With COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  All patients with confirmed COVID-19 and suspected COVID-19

        Exclusion Criteria:

          -  All patients <18 years old
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: The Relationship Between Age and Carpal Tunnel Size

Eligibility criteria:
Inclusion Criteria:

          -  Greater than age 18 having bilateral wrists amenable to ultrasound examination.

        Exclusion Criteria:

          -  Active carpal tunnel syndrome,

          -  history of carpal tunnel syndrome

          -  any prior arm or hand surgery (including previous carpal tunnel release for any reason
             or previous surgery on the volar wrist)

          -  distal radius fracture deformity

          -  rheumatoid arthritis

          -  open wounds or lesions of the hand or forearm

          -  known congenital deformities of the upper extremity.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Out Patient Talc Slurry Via Indwelling Pleural Catheter for Malignant Pleural Effusion Vs Usual Inpatient Management

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of malignant pleural effusion

          2. WHO performance status 2 or less unless performance status is impaired by presence of
             effusion and likely to significantly improve with drainage

          3. Expected survival greater than 3 months

        Exclusion Criteria:

          1. Age less than 18 years old

          2. Pregnant or lactating

          3. Known allergy to Talc or Lignocaine

          4. Lack of symptomatic relief from effusion drainage

          5. At least twice weekly drainage cannot be undertaken

          6. Lymphoma or small cell carcinoma except*:

               1. Failure of chemotherapy

               2. Deemed for palliative management

          7. Non malignant effusions

          8. Loculated pleural effusion

          9. Unable to provide written informed consent to trial participation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Hydrocortisone Treatment for Symmetric Lipomatosis Associated With Neuropathy (SLN): an N-of-1 Study Hydrocortisone Treatment for Symmetric Lipomatosis Associated With Neuropathy (SLN): an N-of-1 Study

Eligibility criteria:
The study is especially designed for a specific female patient. The patient is 31 years old
        at the moment. Since the study is especially designed for this patient, there are no formal
        inclusion and exclusion criteria. However, the study will be stopped when the patient gets
        pregnant as this can influence the primary and secondary outcome measures.

        Inclusion Criteria:

          -  N/A

        Exclusion Criteria:

          -  Pregnancy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 31 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients

Eligibility criteria:
Inclusion Criteria:

          -  more than 17 years old, heartburn at least twice a week, naive to antireflux
             medications and antidepressive agents

        Exclusion Criteria:

          -  active esophagitis at endoscopy, contraindications to nortriptyline use
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Testosterone in Female Hypoactive Sexual Desire Disorder

Eligibility criteria:
Inclusion Criteria:

        pre-menopausal females, hypoactive sexual disorder, age 21-40, able to plan intercourse
        with partner -

        Exclusion Criteria:

        -
Female
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction