Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Manual Therapy on Activation of the Descending Pain Inhibitory System in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Knee pain diagnosed with osteoarthritis of the knee using the criteria of the American
             College of Rheumatology

          -  Low or no response to pain medication for osteoarthritis knee pain.

        Exclusion Criteria:

          -  Suffer from any disorder, syndrome or disease that may cause myofascial or neuropathic
             pain in the lower limbs, such as lumbar radiculopathy, meralgia paresthetica or
             saphenous nerve entrapment.

          -  Infiltration with steroids or local anaesthetics during the year prior to the
             patient's participation in the study or during follow-up.

          -  History of previous lower extremity or lumbopelvic surgery.

          -  Ingestion of substances of abuse that may interfere with treatment.

          -  Contraindications to perform joint therapy mobilizations.

          -  Previous diagnosis of myopathy or neuropathy (lumbo-sacral plexus)

          -  Cognitive deficit manifested in the clinical history (Alzheimer, dementia).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Neuro-muscular Exercise Training Verses Quadriceps Training in Mild to Moderate Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  UL/BL knee OA,

          -  Age 40-65, both genders,

          -  American college of rheumatology criteria for knee OA,

          -  Grade 2 or 3 on Kellgren/Lawrence classification for Knee OA.

        Exclusion Criteria:

          -  Knee surgery

          -  Rheumatoid arthritis

          -  Any neurological condition affecting lower limbs and balance

          -  Use of assistive devices for walking.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Lesinurad and Allopurinol Combination Extension Study in Gout

Eligibility criteria:
Inclusion Criteria:

          -  Subject is able to understand the study procedures and the risks involved and is
             willing to provide written informed consent before the first study related activity.

          -  Subject completed the double-blind treatment period in either Study RDEA594-301 or
             RDEA594-302 and was actively receiving and tolerating study medication (lesinurad or
             placebo) and allopurinol at the Month 12 visit.

          -  Subject is male or female; female subjects of childbearing potential must agree to use
             an effective non-hormonal method of birth

        Exclusion Criteria:

          -  Subject has any medical or psychological condition, which in the opinion of the
             Investigator and/or the Medical Monitor, might create undue risk to the subject or
             interfere with the subject's ability to comply with the protocol requirements, or to
             complete the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women,aged 20-35 years who wish to use a contraceptive.

          -  Women without reproductive system infection complications.

          -  Willingness to not use other forms of hormonal treatment.

          -  Three regular menstrual cycles before the study(21-35 days per cycle with 3-7 day's
             bleeding period, without amenorrhea or irregular bleeding).

          -  Signed informed consent prior to entry into the trial.

        Exclusion Criteria:

          -  Any contraindication to the use of oral contraceptives.

          -  Vascular, metabolic, hepatic, renal, oncologic and other diseases.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Safety & Efficacy of a Combination Niacin ER/Simvastatin in Patients With Dyslipidemia: A Dose-Ranging Study - SEACOAST

Eligibility criteria:
Inclusion Criteria:

          -  Patient has primary Type II hyperlipidemia or mixed dyslipidemia

          -  If the patient is currently taking anti-dyslipidemic medications other than Zocor,
             he/she is willing to withdraw from these medications

          -  Reasonable compliance with a standard cholesterol-lowering diet for a minimum of 4
             weeks prior to screening and for the duration of the study.

          -  LDL-C levels and/or Non HDL-C levels above normal for patients

        This study will be conducted both in the USA and internationally.

        Exclusion Criteria:

          -  Patient has an allergy, hypersensitivity, or intolerance to niacin, statins, or their
             derivatives

          -  HbA1c ≥ 9% in diabetic patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Safety and Efficacy of Turoctocog Alfa in Haemophilia A Subjects

Eligibility criteria:
Inclusion Criteria:

          -  Male subjects with the diagnosis of severe (FVIII less than or equal to 1%)
             haemophilia A from age 12 (except for Israel where the age limit will be 18 for the
             first 10 subjects recruited in the trial) to 56 years having a weight of 10 to 120 kg

          -  Documented history of at least 150 exposure days to any other FVIII products
             (prevention or treatment of bleeds)

          -  No history of FVIII inhibitors greater than or equal to 0.6 BU/mL. The inhibitor
             should be measured regularly for at least the last 8 years or since the first
             treatment of haemophilia A

          -  No detectable inhibitors to FVIII (greater than or equal to 0.6 BU/mL) (as assessed by
             a Central Laboratory at the time of screening)

        Exclusion Criteria:

          -  Congenital or acquired coagulation disorders other than haemophilia A

          -  Creatinine levels 50% above normal level (as defined by central laboratory range)

          -  Known or suspected allergy to trial product (N8) or related products
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: PooR Embryo Yield Cleavage Stage Versus blaStocyst Embryo Transfer

Eligibility criteria:
Inclusion Criteria:

          -  First autologous IVF cycle

          -  Written, informed consent

        Exclusion Criteria:

          -  Planned gestational carrier

          -  Planned donor egg

          -  Morbid obesity: BMI >40

          -  History of recurrent pregnancy loss (≥2 spontaneous abortions)

          -  Presence of uterine factor infertility

          -  Treatment plan includes embryos cultured 'out of protocol'

          -  Planned preimplantation genetic testing
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 44 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Effect of Woodsmoke on Vascular Function

Eligibility criteria:
Inclusion Criteria:

          -  Non-smoking healthy male firefighters or volunteers

        Exclusion Criteria:

          -  Current smoker or regular users of snus

          -  History of lung or ischaemic heart disease

          -  Malignant arrhythmia

          -  Systolic blood pressure >190mmHg or <100mmHg

          -  Renal or hepatic dysfunction

          -  Previous history of blood dyscrasia

          -  Unable to tolerate the supine position

          -  Blood donation within the last 3 months

          -  Recent respiratory tract infection within the past 4 weeks

          -  Routine medication including aspirin and NSAIDs
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Healthy volunteer (health status confirmed by brief History and Physical Exam and
             blood work)

          -  Age 8 years and older (no upper limit) for blood, urine, and buccal mucosa sampling

        Or

        Ages 18 years or older (no upper limit) for bone marrow or normal tissue sampling and/or
        leukapheresis cells

        Or

        Pregnant women (health status confirmed by brief History and Physical Exam and blood work)
        must be 18 years or older (no upper limit) for blood and/or buccal mucosa sampling

          -  Able to comprehend the investigational nature of the protocol and provide informed
             consent (If the healthy volunteer is a minor, the minor s parent or guardian must
             provide consent and the minor must be able to provide assent)

          -  Must be willing to allow samples to undergo genetic studies.

        EXCLUSION CRITERIA:

          -  Healthy volunteers and/or pregnant women with diseases with an inflammatory or immune
             component

          -  Subjects with active infections requiring systemic antibiotic therapy

          -  Persons who are alcoholic or abusers of illicit substances
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 8 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Predicting Outcomes for Covid-19 Using Sonography

Eligibility criteria:
Inclusion Criteria:

          -  Any adult (18 or more years of age) presenting to the emergency department with
             symptoms suspicious for Covid-19

          -  This individual underwent evaluation for Covid-19 via a nasopharyngeal RT-PCR

          -  This individual received a lung ultrasound by the study authors within 28 days from
             initial evaluation

        Exclusion Criteria:

          -  Any individual who did not receive a lung ultrasound within 28 days from initial
             evaluation for covid-19 related illness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment