Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Observational Registry of NovoSeven® Used as On-demand Treatment of Bleeds in Patients With Haemophilia A and B With Inhibitors

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with haemophilia A or B with inhibitors

          -  Experience mild to moderate spontaneous bleeds which require on-demand treatment and
             who are currently prescribed activated recombinant human factor VII

          -  Be able and willing to provide informed consent (or proxy consent by caregiver, if
             applicable), as required by local research ethics committee, governmental or
             regulatory authorities

          -  Be willing to provide information on at least one alternate contact person in the
             event that the patient be somehow lost-to-follow-up over the course of registry
             participation (not applicable if patient is withdrawn)

        Exclusion Criteria:

          -  Known hypersensitivity to the active substance or the excipients in the formulation of
             activated recombinant human factor VII, or to mouse, hamster or bovine protein
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Letrozole in Stimulated IVF Cycles

Eligibility criteria:
Inclusion Criteria:

          -  women under 42 years of age

          -  medical indication for IVF treatment

          -  antral follicle count prior to ovarian stimulation >=3

          -  informed consent

        Exclusion Criteria:

          -  women using donor oocytes

          -  women undergoing preimplantation genetic diagnosis

          -  women with abnormal uterine cavity shown on hysterosalpingogram or saline infusion
             sonogram

          -  women with hydrosalpinges shown on scanning and not corrected

          -  previous documented poor response (<=3 oocytes) to ovarian stimulation using at least
             FSH 225 IU daily
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 42 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: The Natural History of Reproductive and Overall Health in Girls and Women With a Pre-Mutation in the FMR1 Gene; Creation of a Patient Registry

Eligibility criteria:
-  INCLUSION CRITERIA:

               1. Women ages 18 and older

               2. FMR1 CGG repeats numbering between 55 and 199, as determined by standard Southern
                  blot and PCR techniques.

        EXCLUSION CRITERIA:

          1. Males

          2. Children

          3. Women who do not have an FMR1 pre-mutation (CGG repeat number <55 or >199)

          4. Inability to make personal medical decisions

        CRITERIA FOR SCREENING FOR THE FMR1 PRE-MUTATION:

          1. Family history of Fragile X syndrome or mental retardation

          2. Personal or family history of primary ovarian insufficiency (or POF or premature
             menopause )

          3. Personal or famiy history of tremor ataxia syndrome or Parkinson s disease
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Effect of Ulipristal Acetate on Bleeding Patterns and Dysmenorrhea in Women With Adenomyosis

Eligibility criteria:
Inclusion Criteria

          -  18-51 years old

          -  PBAC score greater than 100

          -  Ultrasound or MRI findings of adenomyosis

        Exclusion Criteria

          -  Inability to comprehend written and/or spoken English or Spanish

          -  Inability to provide informed consent

          -  Current uterine, breast, cervical or ovarian cancer

          -  Unwilling to use contraception

          -  Positive pregnancy test or planning pregnancy during the study period

          -  Submucosal uterine fibroids (or greater than a certain size)

          -  Current premalignancy or malignancy

          -  Endometrial ablation or uterine artery embolization

          -  Known hemoglobinopathy

          -  Known severe coagulation disorder

          -  Large uterine polyp (>2cm)

          -  BMI >40

          -  Previous or current treatment with SPRM or GnRH agonist

          -  Progestins, acetylsalicylic acid, mefenamic acid, anticoagulants, antifibrinolytic
             drugs, systemic glucocorticoids within 1 month of enrollment
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 51 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Oral Contraceptive Pills Versus Expectant Management for Retained Pregnancy Products

Eligibility criteria:
Inclusion Criteria:

          1. Patients going through a Misoprostol or Misoprostol/Mifepristone induced procedure
             after a spontaneous 1st trimester pregnancy loss or as a 1st trimester planned
             pregnancy termination and present retained pregnancy products by a trans-vaginal
             ultrasound scan.

          2. Patients after a surgical evacuation of pregnancy products (dilatation and curettage -
             D&C) of a 1st trimester miscarriage and present retained pregnancy products by a
             trans-vaginal ultrasound scan.

          3. All retained products included are of a previously confirmed intra-uterine
             pregnancies.

          4. Asymptomatic patients or mild symptoms of bleeding (spotting).

          5. Presence of a measurable hyperechoic material by 2 dimensional TVUS

        Exclusion Criteria:

          1. Retained products with any of the following clinical presentations : more than a mild
             vaginal bleeding, hemodynamic instability, signs of infection and/or abdominal pain.

          2. Any suspicion of a molar pregnancy.

          3. A known contra-indication for the use of oral contraceptives
Female
Accepts Healthy Volunteers
Subject must be at least 16 Years old.
Subject must be at most 54 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Giant Cell Arteritis and PET Scan (GAPS) Study

Eligibility criteria:
Inclusion Criteria:

          -  Rheumatologist, neurologist or ophthalmologist suspect diagnosis of GCA

          -  Age > 50

          -  Meet at least 2 of 1990 American College of Rheumatology classification criteria for
             GCA

               1. Age >= 50

               2. ESR >= 50

               3. New onset localised headache

               4. Temporal artery abnormality (tenderness or decreased pulsation)

               5. Positive biopsy (will not be available at time of enrolment)

        Exclusion Criteria:

          -  Corticosteroid therapy for > 72 hours before first PET scan

          -  Prolonged corticosteroid therapy (> 1 week) for another indication in past 6 months

          -  History of vasculitis or connective tissue disease

          -  Active malignancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Double-dose Rabeprazole Accelerates and Sustains the Control of Symptoms in Patients With NERD

Eligibility criteria:
Inclusion Criteria:

          -  heartburn and/or reflux at least twice weekly in the absence of visible esophageal
             mucosal breaks at endoscopy

        Exclusion Criteria:

          -  pregnancy

          -  lactation

          -  Hx of gastric surgery

          -  Hx of gastric cancer or peptic ulcer

          -  major medical problems (including CHF, renal failure, COPD, asthma, liver cirrhosis)

          -  severe systemic illness

          -  Hx of malignancy, allergy Hx to rabeprazole

          -  patients who had taken antibiotics

          -  antisecretory agents including H2-blocker

          -  PPI within 4 weeks before endoscopy

          -  current usage of steroids, NSAIDs, aspirin, anticoagulant medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Post Prandial High Resolution Impedance- Manometry

Eligibility criteria:
Inclusion Criteria:

          -  Patient of both gender older than 18 years

          -  Patient referred for post prandial esophageal high resolution manometry combined with
             impedance and ambulatory 24-h pH-impedance monitoring on proton pump inhibitor

          -  Heartburn and/or regurgitation despite double dose proton pump inhibitor therapy

          -  Proven Gastro-esophageal reflux disease off proton pump inhibitor (Los Angeles grade
             B, C or D esophagitis and/or esophageal acid exposure > 5% on esophageal pH monitoring
             off proton pump inhibitor)

          -  Absence of major esophageal motility disorders (achalasia, esophago-gastric junction
             outflow obstruction, esophageal spasm, jackhammer esophagus, absent contractions)

          -  Patient who does not decline to participate to the study

        Exclusion Criteria:

          -  Patient younger than 18 years

          -  Pregnancy or breast feeding

          -  Previous history of esophago-gastric surgery ( including anti-reflux surgery, Heller
             myotomy, bariatric surgery)

          -  Patient with severe renal insufficiency

          -  Patient with severe cardiac insufficiency

          -  Patient legally incompetent or unable to give consent

          -  Patient who declines to participate to the study

          -  Participation to another study at the same time
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Human Menopausal Gonadotropin (HMG) vs Recombinant Follicle Stimulating Hormone (rFSH) in Gonadotropin Releasing Hormone (GnRH) Antagonist Cycles

Eligibility criteria:
Inclusion Criteria:

          -  women with good physical and mental health

          -  aged 18-37 years

          -  regular menstrual cycles ranging from 25 to 35 days; body mass index (BMI) < 30 kg/m2

          -  normal basal serum FSH (≤ 10 IU/L) and E2 (≤ 75 pg/mL) levels determined on the day 3
             of the cycle previous to COH

          -  no uterine (fibroids, adenomyosis, mullerian malformations), ovarian (endometrioma,
             polycystic ovaries) or adnexa (hydrosalpinx) abnormalities assessed by vaginal
             ultrasound.

        Exclusion Criteria:

          -  patients with a history of recurrent pregnancy loss

          -  any significant systemic disease, endocrine or metabolic disorder

          -  having concomitant medication interfering with the purposes of the study

          -  patients who have received any ovulation induction drug within one month before their
             inclusion in the study.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 37 Years

Eligibility (NLI label): Contradiction