Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Tricaprilin in Mild to Moderate Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Informed Consent Form signed by patient and caregiver

          -  Diagnosis of probably Alzheimer's disease of mild to moderate severity

          -  Age 50 or older

          -  If female, 2 years postmenopausal or surgically sterile

          -  Hearing, vision, and physical abilities adequate to perform assessments (corrective
             aids allowed)

          -  Caregiver to attend all visits, perform assessments, and supervise administration of
             study medication

          -  CT or MRI within 24 months prior to screening compatible with a diagnosis of probably
             Alzheimer's disease

          -  Modified Hachinski Ischemia Scale score of 4 or less

          -  ADAS-Cog score between 15 and 35 inclusive at screening

          -  MMSE score between 14 and 24 inclusive at screening

          -  Stable medical condition for 3 consecutive months immediately prior to baseline

          -  No clinically significant abnormal findings on the physical examination, medical
             history, or clinical laboratory results during screening

        Exclusion Criteria:

          -  Any condition that would, in the opinion of the Principal Investigator, render the
             patient or the caregiver unsuitable for the study, or place them at substantial risk
             of adverse outcome

          -  Unwillingness or inability of the patient and/or caregiver to fulfill the requirements
             of the study

          -  Resident in a skilled nursing facility

          -  Any significant neurological disease other than probable AD (e.g. Parkinson's disease,
             Huntington's disease, brain tumor, normal pressure hydrocephalus, progressive
             supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, history
             of stroke, or history of head injury requiring hospitalization)

          -  An alternate cause for dementia other than AD as determined by a required CT or MRI
             scan within 24 months prior to screening

          -  Current history of major psychiatric disorder

          -  Major depression as determined by a Cornell Scale for Depression in Dementia

          -  Clinically significant hypothyroidism

          -  Clinically significant B12 deficiency

          -  Unstable or clinically significant cardiovascular disease

          -  Diabetes of any type

          -  History of tertiary syphilis

          -  Cancer within 3 years prior to baseline, with the exception of squamous and basal cell
             carcinoma

          -  Vital sign abnormalities

          -  Clinically significant renal disease or insufficiency

          -  Clinically significant hepatic disease or insufficiency

          -  Alcohol consumption greater than 2 oz of spirits per day or 14 oz per week (1 oz of
             spirits is equal to 6 oz of wine or 12 oz of beer)

          -  Current history of alcohol abuse or other substance abuse within 24 months prior to
             baseline

          -  Known HIV infection

          -  Use of any investigational compound within 30 days prior to screening

          -  Use of prohibited medications (contact site for details)

          -  Prior or current use of medium-chain triglycerides (MCTs) for medical purposes

          -  Known allergies to coconut oil
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction