Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Clinical Applications of a Smart Physical Examination System for the Health Management in Elderly

Eligibility criteria:
Inclusion Criteria:

          -  Normal upper extremity function

          -  Walk for at least 10 meters without help

        Exclusion Criteria:

          -  Any conditions that could affect the balance function

          -  Deficits in vision or hearing

          -  Mental conditions that preclude the understanding of the protocol
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 55 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Comparison of Autogenous Dentin Matrix Versus Bovine-Derived Xenograft for Socket Preservation

Eligibility criteria:
Inclusion Criteria:

          -  Teeth indicated for extraction and subsequent implant placement

          -  Age group of 18 to 55 years

          -  Single rooted tooth indicated for extraction due to endodontic failure, caries or
             Fracture

          -  Presence of >2 mm keratinized tissue to allow flap management

          -  Extraction site should have adjacent tooth on either side

          -  Systemically healthy patients

          -  Class II or III extraction socket defects according to Hammerele and Jung(2008)

          -  Full mouth plaque score(FMPS)<25% at baseline.(PI)

          -  Full mouth bleeding score(FMBS)<25% at baseline. (BI)

        Exclusion Criteria:

          -  .Presence of dehiscence or fenestration in any of the socket, more than 50% of bone
             loss in any of the socket walls

          -  Medical conditions contraindicating surgical interventions

          -  Known smokers and alcoholics

          -  Subjects with known bone metabolic disorders.(Pagets disease,fibrous dysplasia etc.)

          -  Acute infections at the site of extraction. Eg , Abscess

          -  History of malignancy

          -  Patients who have undergone radiotherapy or chemotherapy

          -  Periapical pathology such as granulomas, cyst, hypercementosis, ankylosis.

          -  Pregnant and lactating women

          -  Maxillary and mandibular 3rd molars.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Development of a Milk Product Substitution for Patients Suffering From Xerostomia Caused by Medication

Eligibility criteria:
Inclusion Criteria:

          -  Patients over 18 years old

          -  Patients seen in the psychiatry department requiring the prescription of psychotropic
             drugs (antidepressants anxiolytics) for over 6 weeks

          -  Patients complaining of xerostomia

          -  Patients having not taken a palliative therapy against xerostomia for at least 2 weeks

          -  Patients having signed a free and informed consent form

          -  Patients affiliated to a social security system

        Exclusion Criteria:

          -  Patients suffering from psychotic illness

          -  Patients suffering from Sjogren's syndrome

          -  Patients having been treated by radiation therapy for head or neck cancer

          -  Patients having stopped a palliative therapy against xerostomia for less than 2 weeks

          -  Patients under 18

          -  Pregnant or Breastfeeding women

          -  Incapacitated adults

          -  Patients placed under tutorship or curatorship

          -  Patients under judicial protection

          -  Patients suffering from milk allergy or lactose intolerance

          -  Patients allergic to curcumin
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: IGF and Other Neurotrophic Factors in Patients With Dementia

Eligibility criteria:
Inclusion Criteria:

          -  dementia, controls(lumbar puncture at our department)

        Exclusion Criteria:

          -  <18år

          -  other CNS disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Psychological Therapy for Patients With ALS

Eligibility criteria:
Inclusion Criteria:

          -  confirmed diagnosis of Amyotrophic Lateral Sclerosis

          -  minimum age of 18 years

          -  fluent in German language

          -  ability to visit the institution providing the intervention at the start of therapy
             (in the course of treatment, telephone-sessions may be offered)

          -  ability to report on thoughts and feelings (by speaking, writing or via communication
             devices)

          -  cognitive ability to give written informed consent

          -  expected remaining lifetime of at least 9 months

        Exclusion Criteria:

          -  inability for communicate (neither via speaking, writing or communication devices)

          -  currently in psychotherapeutic treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Hyperbaric Oxygen Therapy for Cognition in Diabetic Elderly at High Dementia Risk

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of T2D

          -  Diagnosis of MCI

          -  > the age of 65

          -  Hebrew fluency

          -  An informant

        Exclusion Criteria:

          -  Brain disease that affects cognition (e.g. Parkinson's disease, schizophrenia).

          -  Stroke

          -  Epilepsy

          -  Chest pathology incompatible with HBOT

          -  Inner ear disease

          -  Claustrophobia

          -  Cholinesterase inhibitors

          -  Subjects with an indication for HBOT

          -  Counter-indication for MRI or PET

          -  Individuals with severe cataracts must have cataract operations before enrolling in
             the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: The Circadian Rhythm in CusHing SyndrOme in Active Phase and dUring RemiSsion (TheHOURS)

Eligibility criteria:
Inclusion Criteria:

          -  Cushing Syndrome during active phase

        Exclusion Criteria:

          -  Malignancy

          -  Alcoholism or drug addiction

          -  Psychiatric disorders

          -  Clinical or laboratory signs of significant cardiovascular, hepatobiliary disease

          -  Clinically significant renal dysfunction

          -  Pregnancy

          -  Any medication with agents which could interfere with glucocorticoid kinetics and
             melatonin secretion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: ATHN 9: Severe VWD Natural History Study

Eligibility criteria:
Inclusion Criteria:

          1. Participants with severe Von Willebrand Disease with Type 3 VWD or VWF:RCo, VWF:GPlbM
             or VWF:Ag ≤30% of pooled normal control plasma on more than one occasion;

          2. Participants with clinically severe VWD as defined by VWF:RCo, VWF:GPlbM or VWF:Ag
             ≤40% of normal with severe bleeding phenotype defined as requiring recurrent use of
             factor concentrates; and

          3. Co-enrollment in the ATHNdataset.

        Exclusion Criteria:

          1. Diagnosis of platelet-type VWD;

          2. Diagnosis of acquired VWD (clinical diagnosis based on association with
             hypothyroidism, lymphoproliferative and myeloproliferative disorders, malignancies and
             cardiovascular disease, typically aortic stenosis or LVAD).
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: A Comparative, Controlled, Clinical Investigation and Quality Control of a New Hearing Aid

Eligibility criteria:
Inclusion Criteria:

          -  All classifications of hearing loss (sensorineural, conductive, mixed)

          -  If the hearing loss is conductive or mixed it must be approved for amplification by a
             physician

          -  All shapes of hearing loss (flat, sloping, reverse slope, notch)

          -  Severity ranging from mild to severe

          -  German speaking

          -  Ability and willingness to sign the consent form

        Exclusion Criteria:

          -  Contraindications for amplification

          -  Active ear disease

          -  Inability to follow the procedures of the study due to language problems,
             psychological disorders, dementia, or other cognitive problems of the participant,

          -  A reduced mobility making them unable to attend weekly study appointments

          -  A reduced ability to describe auditory impressions and the usage of the hearing aids

          -  Uncooperative so that it is not possible to record a valid pure tone audiogram

          -  A strongly reduced dexterity

          -  Central hearing disorders

          -  Bernafon employees

          -  Family members of Bernafon employees
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Multicentre Observational Study on Management COVID 19 Positive Outpatients in a French Cluster.

Eligibility criteria:
Inclusion Criteria:

          -  patients with covid 19 symptoms

          -  patients who had a contact with a person PCR Covid 19+

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.


Subject must be at most 99 Years

Eligibility (NLI label): Entailment