Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Ketoprofen Topical Patch, 20% in the Treatment of Pain Associated With Osteoarthritis Flare of the Knee

Eligibility criteria:
Inclusion Criteria:

          -  Males or females 18 years of age or older

          -  Diagnosis of osteoarthritis of the knee (unilateral or bilateral)

          -  Meet pain entry criteria

          -  Willing to discontinue use of all analgesic medications (including over-the-counter
             [OTC] analgesics) except those provided as the study treatment and rescue medication
             specifically for study purposes.

        Exclusion Criteria:

          -  Positive urine pregnancy test, pregnant or lactating.

          -  Have fibromyalgia, inflammatory arthritis, gout, pseudo-gout or Paget's disease

          -  Have any other type of clinically significant joint disease or have had joint
             replacement surgery at the index knee

          -  Have received either a corticosteroid injection in the 4 weeks preceding the screening
             visit or hyaluronic acid within 6 months of the screening visit

          -  Have a history or physical examination finding that is incompatible with safe
             participation in the study or study product use

          -  Are taking medications or other substances contraindicated due to the nature of the
             study medication or the potential for drug interactions.

          -  Have significant renal or hepatic impairment

          -  Are taking a sleep medication at a dose that has not been stable for at least 3 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Proprioception and BRACE Training in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Age 50-70 years. 2. Both Males and Females 3. Knee osteoarthritis unilateral and
             bilateral (12). 4. American College of Rheumatology (ACR) criteria for diagnosing
             osteoarthritis of knee joint is presence of pain in knee joint plus any three of six
             factors listed below (13). Age more than 50 y Presence of crepitus on active motion
             Less than 30 min of morning stiffness Bony tenderness Bony overgrowth No palpable
             warmth of synovium 5. Mini-mental state examination (MMSE) 23 or higher (14). 6. Berg
             Balance Scale (BBS) 30-45 points (4)

        Exclusion Criteria:

          -  History of stroke during the previous 12 months 2. History of cardiovascular or
             musculoskeletal diseases, 3. Previously used medication for the central nervous
             system. 4. Presence of lower limb lesions or fractures in the last six months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: CATER: Comprehensive Alveolar and Tooth Esthetic Replacement

Eligibility criteria:
Inclusion Criteria:

          -  At least 18 years of age

          -  Willing and able to provide informed consent

          -  In need of one implant to replace a missing tooth

          -  At least 20 teeth in good repair and occlusion

          -  Sufficient bone volume for dental implant placement without required bone augmentation

          -  Site development (soft and/or bone tissue) performed at least 5 months before implant
             placement, when required

        Exclusion Criteria:

          -  Current smoker

          -  Implant cannot be placed without bone graft

          -  Unable to pay for crown

          -  Untreated rampant caries and/or uncontrolled periodontitis

          -  Absence of adjacent (mesial and/or distal) natural tooth

          -  Uncontrolled diabetes

          -  Systemic or local disease or condition that would compromise post-operative healing
             and/or osseointegration

          -  use of bisphosphonates

          -  History of radiation in the head and neck region

          -  Unable or unwilling to return for follow-up visits

          -  Unrealistic esthetic or functional demands

          -  Unlikely to be able to comply with study procedures

          -  Unwilling or unable to provide informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Ménière's Disease Registry

Eligibility criteria:
Inclusion Criteria:

          -  Adults aged 18 and over.

          -  A probable or definite diagnosis of unilateral or bilateral Meniere's disease as
             defined by the 2015 edition of the American Academy of Otolaryngology-Head and Neck
             Surgery (Goebel 2016)

          -  A willingness to provide consent for data from health records to be used for research
             purposes.

        Exclusion Criteria:

          -  Unable to provide consent

          -  Unable/unwilling to complete questionnaires
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP)

Eligibility criteria:
Inclusion Criteria:

          -  Men or women 18 to 80 years of age inclusive, at the time of signing the informed
             consent

          -  Willing and able to provide informed consent

          -  Had a close contact of a person (index) with known PCR-confirmed SARS-CoV-2 infection
             or who is currently being assessed for COVID-19. Close contact defined as:

               1. Household contact (i.e., residing with the index case in the 14 days prior to
                  index diagnosis)

               2. Medical staff, first responders, or other care persons who cared for the index
                  case without personal protection (mask and gloves)

          -  Less than 4 days since last exposure (close contact with a person with SARS-CoV-2
             infection) to the index case

          -  Body weight < 100 kg (self-reported)

          -  Access to device and internet for Telehealth visits

        Exclusion Criteria:

          -  Known hypersensitivity to HCQ or other 4-aminoquinoline compounds

          -  Currently hospitalized

          -  Symptomatic with subjective fever, cough, or sore throat

          -  Current medications exclude concomitant use of HCQ

          -  Concomitant use of other anti-malarial treatment or chemoprophylaxis

          -  History of retinopathy of any etiology

          -  Psoriasis

          -  Porphyria

          -  Known bone marrow disorders with significant neutropenia (polymorphonuclear leukocytes
             < 1500) or thrombocytopenia (< 100 K)

          -  Concomitant use of digoxin, cyclosporin, cimetidine, or tamoxifen

          -  Known liver disease

          -  Known long QT syndrome

          -  Use of any investigational or non-registered drug or vaccine within 30 days preceding
             the first dose of the study drugs, or planned use during the study period
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Detection of Kisspeptins and miRNAs in Patients With Non-viable Pregnancy

Eligibility criteria:
Inclusion Criteria:

          -  Patients who will perform SET.

          -  Patients using own oocytes.

        Exclusion Criteria:

          -  Complicated uterine cavity.
Female

Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Proton Pump Inhibitor (PPI) Therapy for Newly Diagnosed Esophagitis

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 or older

          -  Have either mild-to-moderate erosive reflux esophagitis

          -  Meet criteria for GERD symptoms.

        Exclusion Criteria:

          -  Patients already on esomeprazole therapy, have previously failed to respond to
             esomeprazole, or are intolerant to PPI therapy.

          -  Patients expected to travel outside of the United States during the initial 8 weeks of
             PPI therapy.

          -  Pregnant women will be excluded as PPI's are not thought safe for the fetus (Pregnancy
             Category C). - Children younger than 18 years of age will be excluded.

          -  Other vulnerable populations, such as those with diminished mental acuity, will be
             excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Intra-Articular Morphine Versus Bupivacaine on Knee Motion in Patients With Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Older than 50 years with a radiological confirmation of chronic knee osteoarthritis

          -  Pain lasting for more than 3 months either at rest or under strain, morning stiffness

          -  Absence of heat at the site

          -  Crepitation during movement and a pain score ranging from three to ten.

        Exclusion Criteria:

          -  Patients with coagulopathy

          -  Infection or malignant disease

          -  Patients who underwent knee or hip surgery; AND

          -  Patients using opioids 24 hours prior to the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Examining the Impact of Tampon Use on the Vaginal Microbiota

Eligibility criteria:
Inclusion Criteria:

          -  regular menstrual cycles lasting 21-35 days

          -  menses lasting for at least 4 days

          -  current tampon user

          -  good self-reported general health

          -  good self-reported vaginal health

        Exclusion Criteria:

          -  currently pregnant

          -  planning to become pregnant in 4 months following enrollment

          -  difficulty using tampons

          -  current toxic shock syndrome

          -  history of toxic shock syndrome

          -  current sexually transmitted infection

          -  current urinary tract infection

          -  currently using antibiotics

          -  antibiotic use in 4 weeks prior to enrollment

          -  current antifungal use

          -  antifungal use in 4 weeks prior to enrollment

          -  autoimmune condition
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment