Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Internet Surveys and Their Impact on Adherence for Rosacea

Eligibility criteria:
Inclusion Criteria:

          -  Male or female subject with persistent erythema associated with rosacea, age greater
             than 18, who agrees to participate and provide written consent.

          -  Have an Investigator Global Assessment of mild to moderate rosacea (IGA rating between
             2 and 5 in the Investigator Global Assessment score which includes erythema in the
             assessment).

          -  Access to a computer and the internet.

        Exclusion Criteria:

          -  Initiation or change in dose within 4 weeks of baseline of systemic anti-inflammatory
             medication which may influence study outcome.

          -  Use of topical therapy for rosacea within 2 weeks of baseline.

          -  Use of systemic corticosteroids within 4 weeks of baseline. Presence of a concurrent
             medical condition or skin condition, which is determined by the investigator to
             potentially interfere with study outcomes or patient assessments.

          -  Subjects with known allergy or sensitivity to bromonidine topical gel, 0.33% or
             components therein.

          -  Female subjects who are not postmenopausal for at least 1 year, surgically sterile, or
             willing to practice effective contraception during the study. Nursing mothers,
             pregnant women and women planning to become pregnant while on study are to be
             excluded.

          -  Subjects with severe cardiovascular disease or vascular insufficiency.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: A Study (Study 1) to Evaluate the Safety and Efficacy of FMX103 1.5% Topical Minocycline Foam in the Treatment of Facial Papulopustular Rosacea

Eligibility criteria:
Inclusion Criteria:

          1. Moderate-to-severe rosacea (as per the IGA score) on the proposed facial treatment
             area consisting of:

               1. At least 15 and not more than 75 facial papules and pustules, excluding lesions
                  involving the eyes and scalp;

               2. No more than 2 nodules on the face.

          2. Presence of or history of erythema and/or flushing on the face.

        Exclusion Criteria:

          1. Presence of any skin condition and/or Excessive facial hair, on the face that would
             interfere with the diagnosis or assessment of rosacea.

          2. Moderate or severe rhinophyma, dense telangiectasia (score 3, severe), or plaque-like
             facial edema.

          3. History of hypersensitivity or allergy to minocycline, any other tetracycline, or of
             any other component of the formulation.

          4. Active ocular rosacea (eg, conjunctivitis, blepharitis, or keratitis) of sufficient
             severity to require topical or systemic antibiotics.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: African American Alzheimer's Progression Markers - CSF and Neuro-Imaging

Eligibility criteria:
Inclusion Criteria:

          -  Ages 60-85.

          -  Has normal cognition, a diagnosis of mild cognitive impairment, or a diagnosis of
             Alzheimer's disease or mild cognitive impairment.

          -  Self-reported race of African American or non-Hispanic white.

          -  Able to undergo neuropsychological testing, lumbar puncture, and MRI.

          -  English speaking.

        Exclusion Criteria:

          -  History of stroke.

          -  Diagnosis of Parkinson's disease, amyotrophic lateral sclerosis, or another
             progressive neurological disorder which may spare cognition.

          -  Mini-Mental State Examination (MMSE) < 17
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Accuracy of eDiagEPU, a Medical Computerized Tool for EPU

Eligibility criteria:
Inclusion criteria:

          -  Pregnancy of unknown location (hCG + without gestational sac found in ultrasound)

          -  Viable pregnancy with embryo less than 14 weeks of gestation

          -  Non-viable pregnancy ; ectopic pregnancy, complete, incomplete or missed miscarriage

        Exclusion criteria:

        - Incomplete follow up and no diagnosis and lack of data to establish a diagnosis
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic RBD: a Pilot Study

Eligibility criteria:
Inclusion Criteria:

          -  REM sleep behavior disorder according to ICSD-3 criteria

          -  No cognitive deficit or symptom of Parkinsonism

          -  Those with written consent.

        Exclusion Criteria:

          -  who took medication (ex. clonazepam) for REM sleep behavior disorder

          -  with degenerative neurologic disorder (ex. Parkinson's disease, Multiple System
             Atrophy, Lewy-body dementia, etc.)

          -  who took medication that can affect REM sleep behavior disorder (anti-depressant:
             SSRI, TCA, MAO-inhibitor)

          -  who is unable to answer questionnaires

          -  who have hypersensitive reaction to medications

          -  Pregnant women or breastfeeding

          -  who are diagnosed with other parasomnia disorder

          -  with severe medical disorder (severe liver failure, respiratory failure, heart
             failure, malignant tumor, etc.)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: The Cellularity Yield of Three Different 22-gauge FNA Needles

Eligibility criteria:
Inclusion Criteria:

          1. Adult patients (18-88) who are undergoing EUS FNA of pancreatic or peripancreatic
             lesions

          2. Adult patients (18-88) who are undergoing EUS FNA of submucosal masses in the
             esophagus, stomach, duodenum or rectum

          3. Adult patients (18-88) who are undergoing EUS FNA of mediastinal masses.

          4. Adult patients (18-88) who are undergoing EUS FNA of enlarged lymph nodes

        Exclusion Criteria:

          1. Patients younger than 18 yrs old or older than 88 yrs.

          2. Pregnant patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 88 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Optimal Treatment of Miscarriage

Eligibility criteria:
Inclusion Criteria:

          -  nonviable intrauterine pregnancy with retained gestational sac in the uterus

          -  the embryo if visible 5 to 35 mm without a heart beat

          -  vaginal bleeding

          -  circulatory stable

          -  hemoglobin at least 80 g/L

        Exclusion Criteria:

          -  contraindications against misoprostol
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV

Eligibility criteria:
Inclusion Criteria:

          -  Patients will be eligible if they have:

               -  ≥2 syncopal spells in the year preceding enrolment, and

               -  ≥ -2 points on the Syncope Symptom Score for Structurally Normal hearts, and

               -  Age ≥ 18 years with informed consent.

        Exclusion Criteria:

          -  Patients will be excluded if they have:

               -  other causes of syncope, such as ventricular tachycardia, complete heart block,
                  postural hypotension or hypersensitive carotid sinus syndrome,

               -  an inability to give informed consent,

               -  important valvular, coronary, myocardial or conduction abnormality or significant
                  arrhythmia,

               -  hypertrophic cardiomyopathy,

               -  a permanent pacemaker,

               -  a seizure disorder,

               -  urinary retention,

               -  hypertension defined as >140/90 mm Hg,

               -  hepatic disease,

               -  glaucoma or

               -  a 5-minute stand test resulting in diagnoses of Postural Orthostatic Tachycardia
                  Syndrome or Orthostatic Hypotension.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Electrical Impedance Myography as an Outcome Measure in Amyotrophic Lateral Sclerosis Clinical Trials

Eligibility criteria:
Inclusion Criteria:

          -  Definite or probably ALS by El Escorial criteria

          -  Muscle strength of at 3.5 in one limb

        Exclusion Criteria:

          -  Forced vital capacity of less than 70%

          -  Atypical forms of motor neuron disease (monomelic amyotrophy, primary lateral
             sclerosis)

          -  Pacemaker
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Accuracy of SPD Persona LH Assay When Compared to Ultrasound Observed Ovulation and Other Indices of Ovulation

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  Aged 18 - 40 years

          -  Menstrual cycle length between 23 and 35 days

          -  Had two natural cycles prior to study participation

          -  Using non-hormonal contraception to avoid pregnancy OR abstaining from intercourse for
             the last three months and the present cycle

        N.B: Non hormonal contraception includes barrier methods such as male and female condoms,
        diaphragms or caps, non-hormonal intra-uterine devices such as coils, male and female
        sterilisation or natural family planning

        Exclusion Criteria:

          -  Unwilling to provide written informed consent to participate in the study or comply
             with study procedures

          -  Pregnant

          -  Breastfeeding

          -  Has menopausal symptoms such as night sweats or hot flushes

          -  Using any hormonal treatments e.g. hormonal contraception, fertility treatments and
             hormone replacement therapy (except thyroxin)

          -  Taking antibiotics (based on decision by principle investigator)

          -  Has a diagnosis of polycystic ovarian syndrome (PCOS)

          -  Has impaired liver or kidney function

          -  Intending to use PERSONA as a contraceptive during the study period

          -  Contraindications to frequent blood sampling e.g. anaemia, hypotonia and blood
             clotting diseases

          -  Contraindications to frequent ultrasound examinations e.g. morbid obesity and recent
             abdominal surgery
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction