Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effect of Hypercholesterolemia With or Without Hypertension on Coronary Artery Stenosis in Patients With Angina: a Retrospective Study

Eligibility criteria:
Inclusion Criteria:

          1. Patients aged from 35 to 75 years old, male or female.

          2. Those who were hospitalized between September 1, 2014 and September 1, 2019.

          3. Patients with Coronary heart disease angina pectoris and have undergone coronary
             angiography in the inpatient department of cardiovascular internal medicine.

          4. The diagnosis of hypercholesterolemia, Coronary heart disease angina pectoris and
             hypertension is accorded with the diagnostic criteria.

        Exclusion Criteria:

          1. Those with other cardiac diseases, gastroesophageal reflux disease or hiatal hernia,
             neurosis, spinal or vertebral artery cervical spondylosis, hyperthyroidism,
             climacteric syndrome, etc.

          2. Those with myocarditis, cardiomyopathy, acute myocardial infarction, third degree of
             heart failure, severe heart valve disease, major diseases such as malignant tumor and
             serious metabolic diseases, liver failure or renal failure.

          3. Those with psychotic disorders, or cognitive dysfunction.

          4. Those of childbearing age and have fertility requirements, or pregnant women or
             lactating women.

          5. Those allergic to iodine contrast medium.

          6. Those who are not suitable for the study, as judged by the researcher.
No condition on gender to be admitted to the trial.

Subject must be at least 35 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction