Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Assessment of Efficacy of Low Intensity Resistance Training in Men at Risk for Symptomatic Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  male

          -  ≥ 45 years

          -  has at least one of the following: BMI≥25, frequent knee symptoms on most of the last
             30 days, history of knee injury which rendered individual unable to walk without
             assistance for at least 2 days, history of knee surgery, diagnosis of knee
             osteoarthritis

        Exclusion Criteria:

          -  Resistance training at any time in the last 3 months prior to study

          -  Bilateral knee replacement

          -  Lower limb amputation

          -  Lower limb surgery in the last 6 months that affects walking ability or ability to
             exercise

          -  Back, hip or knee problems that affect walking ability or ability to exercise

          -  Unable to walk without a cane or walker

          -  Inflammatory joint or muscle disease such as rheumatoid or psoriatic arthritis or
             polymyalgia rheumatica

          -  Multiple sclerosis

          -  Known neuropathy

          -  Self-report of Diabetes

          -  Currently being treated for cancer or having untreated cancer

          -  Terminal illness (cannot be cured or adequately treated and there is a reasonable
             expectation of death in the near future)

          -  Peripheral Vascular Disease

          -  History of myocardial infarction or stroke in the last year

          -  History of deep venous thrombosis

          -  Chest pain during exercise or at rest

          -  Use of supplemental oxygen

          -  Inability to follow protocol (e.g. lack of ability to attend visits or understand
             instructions)

          -  Staff concern for subject health (such as history of dizziness/faintness or current
             restrictions on activity)

          -  Concurrent study participation

          -  Unable to attend more than 2 days within any 1 week or unable to attend 4 or more
             sessions during the study
Male
Accepts Healthy Volunteers
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment