Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Randomized Controlled Trials on Laparoscopic No. 14v LNS Dissection

Eligibility criteria:
Inclusion Criteria:• Age from 18 to 75 years

          -  Primary lower third gastric adenocarcinoma (papillary, tubular, mucinous, signet ring
             cell, or poorly differentiated) confirmed pathologically by endoscopic biopsy

          -  cT2-4a, N0-3, M0 at preoperative evaluation according to the American Joint Committee
             on Cancer (AJCC) Cancer Staging Manual Seventh Edition

          -  No distant metastasis is observed. And the spleen, pancreas or other adjacent organs
             are not involved by the tumor.

          -  Performance status of 0 or 1 on Eastern Cooperative Oncology Group scale (ECOG)

          -  American Society of Anesthesiology score (ASA) class I, II, or III

          -  Written informed consent

        Exclusion Criteria:• Women during pregnancy or breast-feeding

          -  Severe mental disorder

          -  History of previous upper abdominal surgery (except laparoscopic cholecystectomy)

          -  History of previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal
             dissection

          -  Enlarged or bulky regional lymph node envelop important vessels

          -  History of other malignant disease within past five years

          -  History of previous neoadjuvant chemotherapy or radiotherapy

          -  History of unstable angina or myocardial infarction within past six months

          -  History of cerebrovascular accident within past six months

          -  History of continuous systematic administration of corticosteroids within one month

          -  Requirement of simultaneous surgery for other disease

          -  Emergency surgery due to complication (bleeding, obstruction or perforation) caused by
             gastric cancer

          -  FEV1<50% of predicted values
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Dose Escalation Study Using Collagenase Clostridium Histolyticum in the Treatment of Lipoma

Eligibility criteria:
Inclusion Criteria:

          -  Clinical history lipoma at least one year and no treatment within last 90 days

          -  Lipoma diagnosed as benign

          -  Lipoma is a single mass with easily definable edges

          -  Lipoma has an area of 2.0 to 17 cm squared

          -  Women of childbearing potential must use an acceptable method of birth control

        Exclusion Criteria:

          -  Lipomas on the head, neck, hand or foot, or female breast

          -  Women who are nursing or pregnant

          -  Subjects who have participated in any investigational drug trial within 45 days of
             enrollment in this study

          -  Subjects with known allergy to collagenase or any of the inactive ingredients in
             XIAFLEX

          -  Subjects with diabetes or any medical condition that would make the subject unsuitable
             for enrollment.

          -  Subjects having a history of trauma in the area of the lipoma

          -  Subjects with a history of connective tissue diseases or rheumatological diseases.

          -  Subjects with uncontrolled hypertension

          -  Subjects currently receiving or planning to receive anticoagulant medication except
             for less than 150 mg aspirin daily and over-the-counter nonsteroidal anti-inflammatory
             drugs) within 7 days before injection of study drug

          -  Subjects having the following laboratory abnormalities:

          -  ALT/AST greater than 3 times the upper limit of normal

          -  Creatinine greater than 2

          -  Hemoglobin/hematocrit and WBC outside the normal range
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient's own account: I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Clinical trial: Clinical Research on Advanced Warning Factors Of Respiratory Injury in Dermatomyositis

Eligibility criteria:
Inclusion Criteria:

          -  adult patients meet the diagnostic criteria for dermatomyositis of Bohan and Peter

        Exclusion Criteria:

          -  complicated with other connective tissue diseases

          -  complicated with cardiovascular and respiratory disease caused by other reasons

          -  interstitial lung disease caused by environment and drugs

          -  patients with key research missing data or without informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Intensive Replacement Treatment in Haemophilia Patients With Synovitis

Eligibility criteria:
Inclusion Criteria:

          1. Male patients with > 12 years of age, with severe (FVIII < 1%) or severe-moderate
             (FVIII < 2%) haemophilia A without inhibitors, receiving a prophylactic treatment with
             FVIII.

          2. Evidence at ultrasound evaluation of synovitis (grade 1-2 according to HEAD-US score)

          3. Signed and dated informed consent form for data collection prior to enrolment.

        Exclusion Criteria:

          1. Patients with bleeding disorders other than haemophilia A

          2. Patients with anti-FVIII inhibitor (any titer).

          3. Patients receiving on-demand treatment with FVIII

          4. Patients with liver cirrhosis

          5. Any condition that compromises the patient's ability to perform study-related
             activities or that poses a clinical contraindication to study participation.

          6. Patients unwilling or unable to follow the terms of the protocol.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: An 8-Week Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Oral Fispemifene for the Treatment of Sexual Dysfunction in Hypogonadal Men

Eligibility criteria:
Inclusion Criteria:

          -  A confirmed diagnosis of secondary hypogonadism

          -  Mild to moderate erectile dysfunction

          -  Ability to read, understand and complete diaries and questionnaires

          -  Ability to safely make sexual attempts during the course of the study

        Exclusion Criteria:

          -  Primary hypogonadism

          -  Hypogonadism as a result of surgery, trauma, tumors or radiation of the hypothalamus
             or pituitary

          -  History or current diagnosis of breast cancer, prostate cancer and/or PSA level above
             ≥3.5 ng/mL

          -  Poorly controlled blood pressure, type 2 diabetes, thyroid disease; sleep apnea

          -  Elevated prolactin level

          -  Hemoglobin >17 g/dL or Hematocrit >50%

          -  Use of transdermal or oral testosterone within 4 weeks, intramuscular testosterone
             therapy within 6 weeks, and testosterone pellets within 6 months prior to Screening
             and at any time throughout the study

          -  Use of another SERM or past participation in a trial with Fispemifene

          -  Use of medications known to alter the HPG axis

          -  Clinically significant findings on physical exam, screening labs, or other findings
             which would prevent safe participation in the study

          -  Participation in another clinical study in the last 30 days
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 64 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

          -  ALS patients admitted to Centre for Rare Diseases, IRCCS Neuromed,

          -  Patients diagnosed ALS within 6 months,

          -  Patients age between 20 years and 75 years old,

          -  Patients underwent to differential diagnosis using diagnostic tools (EMG, NCV, MRI) to
             exclude other diseases with similar signs and symptoms,

          -  Subjects able to communicate verbally or by using a non-verbal communication system.

        Exclusion Criteria:

          -  Pregnant women,

          -  Subjects with malignant tumor,

          -  Subjects/Patients with others neurological or psychiatric disorders,

          -  Subjects/Patients with systemic diseases,

          -  Subjects/Patients with positive blood test for hepatitis B or C, or HIV,

          -  Patients included in other clinical trials,

          -  Subjects/Patients showing inability to understand the informed consent and the study's
             purpose
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Study of the Laboratory-based Evaluation of the Degrees of Activity of Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  medium and large joint active osteoarthritis

        Exclusion Criteria:

          -  refuse of patient to participate in the trial;

          -  acute infectious diseases;

          -  pregnancy/lactation;

          -  intercurrent severe chronic diseases;

          -  HIV, Hepatites B/C;

          -  active tuberculosis;

          -  alcohol use disorder/drug addiction;

          -  malignant neoplasms/leukemia.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Trial of Combination Therapy to Treat COVID-19 Infection

Eligibility criteria:
Inclusion Criteria:

          1. Signed informed consent, demonstrating that the subject understands the procedures
             required for the study and the purpose of the study

          2. Healthy male or female subjects 18 years of age to 75 years of age

          3. Diabetic and obese (BMI > 30) patients will be included in the Trial but randomization
             will be stratified.

          4. Positive test for COVID-19 by RT-PCR at screening

          5. Subjects must agree to practice at least two highly effective methods of birth control
             for the duration of the study. One of these must be a barrier method. Exceptions for
             females and partners of females that are not of childbearing potential. (e.g.
             surgically sterilized, post-menopausal)

          6. Subjects must agree they will attend the treatment facility daily for 10d in the event
             of failure to attend, the patient will be visited at their home to collect the nasal
             swab and review data.

        Exclusion Criteria:

          1. Refusal to sign informed consent form

          2. Negative test for COVID-19 by RT-PCR at screening

          3. Severe disease symptomatically including pneumonia, respiratory distress, tachypnoea,
             shortness of breath, temperature > 38 degrees C (100.4 degrees F), pleuritic pain, or
             frequent cough.

          4. Known drug allergy to any of the investigational medications

          5. Currently taking medication with known drug interactions with investigational
             medications, found in Appendix II

          6. Prescription or other antiviral medications

          7. Any comorbidities which constitute health risk for the subject including known cardiac
             arrhythmias - but will be limited to those on hydroxychloroquine

          8. Inability to attend daily for 10 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Symptom Control and Impact on Daily Life in Patients With Gastroesophageal Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patients known or newly diagnosed with GERD

          -  Patients with typical GERD symptoms as heartburn and regurgitation for ≥2 days in the
             previous week

          -  Patients, currently not treated with a proton pump inhibitor

        Exclusion Criteria:

          -  Patients who have been receiving treatment with non-steroidal antiinflammatory drugs
             within two weeks prior the inclusion in the study

          -  Patients with medical history of surgery of the esophagus, stomach or duodenum

          -  Pregnant or nursing females
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment