Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Non-interventional Observation of Practical Implementation, Efficacy and Safety of Continuous Infusion With KOGENATE Bayer in Surgery

Eligibility criteria:
Inclusion Criteria:

          -  In-patients with diagnosis of severe haemophilia A (FVIII < 1%), heavily pretreated (>
             150 exposure days), without any history of inhibitors, a negative inhibitor test
             should be available, decision taken by the investigator to administer KOGENATE Bayer
             via continuous infusion during and after surgery.
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Assessing Medical Menstrual Regulation in the United States

Eligibility criteria:
Inclusion Criteria:

          1. Age 18-49 years

          2. General good health

          3. Does not want to be pregnant

          4. Does not want to verify pregnancy status at the study site

          5. History of regular monthly menstrual cycles

          6. Missed menses of 1-21 days

          7. Sexual activity in the past 2 months

          8. Willing and able to sign consent forms

          9. Willing to provide urine sample at enrollment

         10. Willing to return for a follow-up visit

        Exclusion Criteria:

          1. Known allergies or contraindications to mifepristone and/or misoprostol

          2. Symptoms of or risk factors for ectopic pregnancy

          3. Current use of an IUD, contraceptive implant or injectable
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Platelet Function in Patients With Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Patients with severe hemophilia A who are being prophylactically treated with FVIII.

          -  Age of at least 2 years.

          -  Bleeding history of at least 6 months.

          -  IRB-approved informed consent.

        Exclusion Criteria:

          -  Presence of FVIII inhibitors.

          -  Greater than 7 days since active bleeding.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Efficacy and Safety Study of Multiple Doses of IMAB362 in Patients With Advanced Gastroesophageal Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Metastatic, refractory or recurrent disease of advanced adenocarcinoma of the stomach
             or the lower esophagus proven by histology

          -  CLDN18.2 expression of the biopsy material from the cancer confirmed by
             immunohistochemistry

          -  At least 1 measurable site of disease according to RECIST criteria

        Exclusion Criteria:

          -  Less than 3 weeks since prior chemo-or radiation therapy

          -  Other concurrent anticancer therapies

          -  Concurrent anticoagulation with vitamin K antagonists

          -  Therapeutic doses of Heparin (prophylactic doses accepted)

          -  Uncontrolled or severe illness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient's own account: I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Clinical trial: Postoperative Telehealth Mindfulness Intervention After Spine Surgery

Eligibility criteria:
Inclusion Criteria:

          1. English-speaking adults (age 18+ years) scheduled for their first lumbar spine surgery
             for a degenerative condition (spinal stenosis, spondylosis with or without myelopathy,
             and spondylolisthesis)

          2. Radiographic evidence of compression of cauda equina or nerve roots by degenerative
             changes

          3. Presence of back and lower extremity pain persisting for at least 3 months

          4. Access to stable internet.

        Exclusion Criteria:

          1. Current/history of a primary psychotic or major thought disorder or hospitalization
             for reasons related to psychosis

          2. Major cognitive disorder

          3. Active substance use disorder, with the exception of tobacco use disorder (in past
             month)

          4. History of bipolar disorder or dissociative disorder

          5. Current PTSD symptoms (in past month)

          6. Having a discectomy procedure and surgery for spinal degeneration secondary to
             scoliosis or radicular symptoms caused by a prolapsed or sequestered disc will be
             excluded
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Rescue of Steroidogenic Capacity in Adrenocortical Failure Study (RADS)

Eligibility criteria:
Inclusion Criteria:

          -  Clear evidence of primary adrenal failure (elevated ACTH, pigmentation, electrolyte
             disturbance)

          -  Basal or stimulated cortisol <400 nmol/l but >100nmol/l

        Exclusion Criteria:

          -  Active viral infection, pregnancy or breast feeding, previous immunosuppression,
             diabetes, cardiorespiratory disease, renal failure, hepatic disease, cancer

          -  Calcified or enlarged adrenals on CT scan, active TB
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Genetic Determinant of Foveolar Hypoplasia in Parents of Albinos Children

Eligibility criteria:
Inclusion Criteria:

          -  children with albinism

          -  father and mother of children with albinism

        Exclusion Criteria:

          -  sign of albinism except fovea plana in father or mother of children with albinism

          -  ophthalmological abnormalities making access to the fundus with OCT impossible
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Human Chorionic Gonadotrophin in an Antagonist Protocol

Eligibility criteria:
Inclusion Criteria:

          1. Indication for ICSI treatment.

          2. The presence of one or two functional ovaries.

          3. Good responders to ovarian stimulation.

          4. The presence of normal uterine cavity

          5. Basal (day 2 or 3) serum FSH (follicle stimulating Hormone) levels ≤13 IU

          6. No untreated endocrinologic disease

        Exclusion Criteria:

          1. Abnormal uterine cavity.

          2. Basal (day 2 or 3) serum FSH levels ≥13 IU.

          3. Poor responders to ovarian stimulation according to the existence of at least two of
             the following criteria:Advanced maternal age (above 40 years), antral follicles count
             <5, prior history of poor response to controlled ovarian hyperstimulation (peak E2
             <500 pg/ml and/or ≤3 oocytes retrieved).

          4. Untreated endocrinologic disease.

          5. Azoospermia. all patients should be managed in Cairo,Egypt
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: GADGET-PD Genetic and Digital Diagnosis of Essential Tremor and Parkinson's Disease Trial

Eligibility criteria:
Inclusion Criteria:

          -  Idiopathic Parkinson's Disease as defined by the UK brain bank criteria and history of
             resting tremor, or:

          -  Essential Tremor with history of resting tremor. Diagnosis made by a movement disorder
             specialist.

          -  Midstage in disease process for Parkinson's disease with history of resting tremor

        Exclusion Criteria:

          -  Dementia as defined by a mini-mental state examination cutoff score of 27

          -  Atypical Parkinsonism

          -  Akinesia/ rigidity Parkinson's Disease

          -  Movement Disorders - Stiff-Person syndrome, choreatic disease, dystonia, progressive
             supranuclear palsy

          -  Motor neuron disease - Multiple sclerosis, amyotrophic lateral sclerosis, motor
             neuritis, progressive bulbar palsy, progressive muscular atrophy, spinal muscular
             atrophy

          -  Significant neurological comorbidities:

               -  Stroke

               -  Brain cancer or brain metastases

          -  History of bone marrow transplant

          -  Cerebral palsy and spastic paraplegia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: SHAPE:SeeingtheHeartwithAIPoweredEcho

Eligibility criteria:
Inclusion Criteria:

          1. Patients indicated for a standard physical examination

          2. Patients ≥65 years old

        For patients in Phase I, one of the following additional inclusion criteria must be
        present:

          1. Patient presenting with a new murmur, or history of a murmur but no prior echo within
             3 years of the exam

          2. Patient presenting with shortness of breath

          3. Unexplained pedal edema

        Exclusion Criteria:

          1. Unable to lie flat for study

          2. Significant anatomical abnormality, recent trauma, or recent thoracic/abdominal
             surgery that would limit the ability to obtain adequate images

          3. Subjects unwilling or unable to give written informed consent

          4. Patients experiencing a known or suspected acute cardiac event Eligibility criteria
             for Phases II and III of this study will be finalized once results from Phase I are
             available. The current plan is to have similar criteria for Phases II and III.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction